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<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYK3</accession>
    <name>A0A6P7EYK3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114324652</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128319.1">
        <property type="nucleotide sequence ID" value="XM_028272518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYK3"/>
    <dbReference type="FunCoup" id="A0A6P7EYK3">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272518.2">
        <property type="protein sequence ID" value="XP_028128319.1"/>
        <property type="gene ID" value="LOC114324652"/>
    </dbReference>
    <dbReference type="GeneID" id="114324652"/>
    <dbReference type="KEGG" id="dvv:114324652"/>
    <dbReference type="InParanoid" id="A0A6P7EYK3"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028128319.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="13161" checksum="FC7224390AE610A6" modified="2020-12-02" version="1">MAVSFAQKRFMSSGLQKWAYNLAGFNRYGLWRDDLLYEDSDVAEALKRVPQKTIDERNYRILRATQLSLSHSILPKEQWTKLEDDKLYLTPFVNQVIKEKKEQEEWNKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZL0</accession>
    <name>A0A6P7EZL0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inactivation-no-after-potential D protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324407</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128042.1">
        <property type="nucleotide sequence ID" value="XM_028272241.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503714.1">
        <property type="nucleotide sequence ID" value="XM_050647757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZL0"/>
    <dbReference type="FunCoup" id="A0A6P7EZL0">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272241.2">
        <property type="protein sequence ID" value="XP_028128042.1"/>
        <property type="gene ID" value="LOC114324407"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647757.1">
        <property type="protein sequence ID" value="XP_050503714.1"/>
        <property type="gene ID" value="LOC114324407"/>
    </dbReference>
    <dbReference type="GeneID" id="114324407"/>
    <dbReference type="KEGG" id="dvv:114324407"/>
    <dbReference type="CTD" id="37629"/>
    <dbReference type="InParanoid" id="A0A6P7EZL0"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23064">
        <property type="entry name" value="PDZ3_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="358"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="495"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="590"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000259" key="2">
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            <dbReference type="PROSITE" id="PS50106"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128042.1"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028128042.1"/>
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    </evidence>
    <sequence length="676" mass="73868" checksum="C30E4A744A2C0008" modified="2020-12-02" version="1">MAVIRQTSYNSDVNKLRKKLQNHWGTIQTVQLYRKCKENLGITAVEGKVKLETSYGIYSEDILGIFIKAVLSNSCAEKTGKFKTGDRILEINGVDLKEASTEQVLQLIGNSESPISFVIQSLLPPLMFNDVQSITPIQSVEINREITQTTETEHHEKHNKSQPLSESESEDDDDEEDVRDLEGRTMTAKGYMIDRASAGNVTRTKDEILNDSEEEDLFGYTMSKIKKKYLNVSHHIVTAQLERFSQEIGLSLAGHKDRNCMAVFVAGLNPQGSAYKSGDIKVGDEILEINGVVLQGRCHLNVSTIIKGLPGPILKIILLRKKTGIDDIAVKPITQFPIADIDAVSEESFKDKFPNVRTVALRKEPTHSLGIMIIEGKHAGVGKGIFISDIQEGGTAEKAGLEIGEMILAVNKDSLIGVTYEVAASLLKNVNGVVTLIVSNPEKKEDKLLSPSSAVDENKNKIASPKSPLPASRSPTPTKDPAADPLVCTICEGKEVTIEIVTENQLLGIFFVGKGDNSTSAYGVILIEIYQKGLADKDQRLQPGDMIMEVNGISLREVPFTTASQALRETGPKVRLIVYRPSQSDYTSFEINLVKKPGRGLGLSVISRKYLKGIYVADIINGGSADLDGGLIKGDLITAVDEKDLANCTEEEASVILKTVSGNARLKINRCKFISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3H5</accession>
    <name>A0A6P7F3H5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phenoloxidase-activating factor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114324417</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128060.1">
        <property type="nucleotide sequence ID" value="XM_028272259.1"/>
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        <property type="nucleotide sequence ID" value="XM_050647763.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050647763.1">
        <property type="protein sequence ID" value="XP_050503720.1"/>
        <property type="gene ID" value="LOC114324417"/>
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    <dbReference type="KEGG" id="dvv:114324417"/>
    <dbReference type="InParanoid" id="A0A6P7F3H5"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="45"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028128060.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33431" checksum="01B0D90EE90A7D5B" modified="2020-12-02" version="1">MDYRIIIVSLSCICVVVPNKDVDNHPNWKLLPKDCGRARETQFRIFGGQDAELGQFPWLVRLKAYAGSFGGFNCGGGLISTRYVLTAAHCGENVTITSVRIGEYDLRSYVDCDDFGCAPPYQDIAVLWYKGHPDWNIKTLQNDVALIKLKWDAVLNAYVQPLCLPGRNNFFKSYKLEGDVQLAGWGHSDAARPGEKIPDILQFVHLKVQEIDFCRTYYKSNDTALLEDRQLCIGQKDGHDTCDGDSGGPVMKELKVDEIYRYYLTGLVSYGYPSCGEAPAIYTNVRYFLHWILDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBZ7</accession>
    <name>A0A6P7FBZ7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspanin-5 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114326712</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130935.1">
        <property type="nucleotide sequence ID" value="XM_028275134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBZ7"/>
    <dbReference type="FunCoup" id="A0A6P7FBZ7">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275134.2">
        <property type="protein sequence ID" value="XP_028130935.1"/>
        <property type="gene ID" value="LOC114326712"/>
    </dbReference>
    <dbReference type="GeneID" id="114326712"/>
    <dbReference type="InParanoid" id="A0A6P7FBZ7"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03159">
        <property type="entry name" value="TM4SF9_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000023">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028130935.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35906" checksum="6D417DCBA93C35D9" modified="2020-12-02" version="1">MTVNVPSMPAVRKYRRDTTEVSSCLKYMIFGFNVLFWLLGLGILTIGVWAWSEKDIFNNLGKVANVALDPAFVLICIGTVTFVIGFTGCVGALRENTCLLATYAIFLSVLLLFEMTAGILGFIFKDWIKSQATIGFQTFIIHYREDPDQQNLIDWIQEDWLQCCGIEGPKDWDRNNYFNCSSKDVGSREACGVPFSCCKRKPNEIIKNKQCGYDVRKPGFPGERHIFERGCLRAGEEWIESNLVPVAAVKVGTMVLQSFDVSKIINEQGCLEAIEDWTEKNMISIASCIFVVLFCHILGICFAQNLRADIFAQKAKWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FF66</accession>
    <name>A0A6P7FF66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">H/ACA snoRNP protein NHP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114329490</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134416.1">
        <property type="nucleotide sequence ID" value="XM_028278615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FF66"/>
    <dbReference type="FunCoup" id="A0A6P7FF66">
        <property type="interactions" value="1224"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278615.2">
        <property type="protein sequence ID" value="XP_028134416.1"/>
        <property type="gene ID" value="LOC114329490"/>
    </dbReference>
    <dbReference type="GeneID" id="114329490"/>
    <dbReference type="KEGG" id="dvv:114329490"/>
    <dbReference type="InParanoid" id="A0A6P7FF66"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000028">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028134416.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17168" checksum="9D1709F4CE2A1A4E" modified="2020-12-02" version="1">MGKIKEEADVSVKEEPQDELSYDEKIANCNAISKPMASKKLAKRCYKLVKKAMKQKTYIRCGLKDVQKRLRKGETGIVLFAGDVWPLEIMCHLPIVCEDKNIPYVFVPSRKDLGAAMGVKRGCLTVLIKPHNEYKDSFDELSEEVKHLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI28</accession>
    <name>A0A6P7FI28_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein zyg-11 homolog B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328259</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132860.1">
        <property type="nucleotide sequence ID" value="XM_028277059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501959.1">
        <property type="nucleotide sequence ID" value="XM_050646002.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501960.1">
        <property type="nucleotide sequence ID" value="XM_050646003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI28"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277059.2">
        <property type="protein sequence ID" value="XP_028132860.1"/>
        <property type="gene ID" value="LOC114328259"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646002.1">
        <property type="protein sequence ID" value="XP_050501959.1"/>
        <property type="gene ID" value="LOC114328259"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646003.1">
        <property type="protein sequence ID" value="XP_050501960.1"/>
        <property type="gene ID" value="LOC114328259"/>
    </dbReference>
    <dbReference type="GeneID" id="114328259"/>
    <dbReference type="KEGG" id="dvv:114328259"/>
    <dbReference type="InParanoid" id="A0A6P7FI28"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF22">
        <property type="entry name" value="ZYG-11 FAMILY MEMBER B, CELL CYCLE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="3">
        <location>
            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="392"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028132860.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="85887" checksum="C9B63FA5B8B76F50" modified="2020-12-02" version="1">MSSSKNRKMFESPDTLEELCLEAFCENILTYIERAEWVKDEESDHWGEVTVYKFKDPEIFLIREVSEKLLKKFVEKRLLCDSLLQIFTQLNTKLKTIRLKRSKITKTGLKILKEHKIVQLECVDMPKIGIGDILDCLNEWSVENMSSVNFAKCSFIDDISRYNFMVRILHLVNLTRLNLAYTELNQKVFEYICEDLKHLQNLDISGTQVTDLRPLTQRSAKLQSLSICDLSCADHVADTLQTMHQLRHLDISFFNDKIDNNVNHLDILPKLEDPNVLPELMLLDISGWKHFICRQFLLKFIETHPKLQVIGIVLCSITFDPVFSDMGDIEYPKNLIIAGLGNEEQIKVTLTKYKDKPTYVQKAIYHLFQLTGDFHEARPDMFNLVLPVMELHTTVFGVQLAATACLYNLTRGEFSKNIHPRSLRKGVNLTLLAMECFPKEFQLQKNSLLTLCSDWILQEVNFDKFRCAKLVLDALCHFDDANMDRMAVAICSILAARISTDETSKLGARPEYMCKLLNMVRRRVDNAIADITLKFTLSALWNLTDESAATCKVFLENSGEDIFLGALKMFRNNSAIETKVLGLLNNIAEVAKLRRNLLTENLMDELFVLLSSENIDVSYFAAGIVANLASEGPDFWTIQNHSREQMLEGLKNSVANWKVPESEMVAYRSFKPFFPLLQTGMDYQVQLWAVWAIHHVCTKNPKRYCHMLLEERGRRILNDLLEYDHTHYEIKNYCCLILQTLPNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIC0</accession>
    <name>A0A6P7FIC0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CCAAT/enhancer-binding protein beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114328235</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132823.1">
        <property type="nucleotide sequence ID" value="XM_028277022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIC0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277022.2">
        <property type="protein sequence ID" value="XP_028132823.1"/>
        <property type="gene ID" value="LOC114328235"/>
    </dbReference>
    <dbReference type="GeneID" id="114328235"/>
    <dbReference type="KEGG" id="dvv:114328235"/>
    <dbReference type="InParanoid" id="A0A6P7FIC0"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF55">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028132823.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23616" checksum="DEABE8892C85FB13" modified="2020-12-02" version="1">MDSQNPPHFRFPENGAENSILPVSAFSTYSLLKNCNYLLTSQSPEPHLKSFLPPELQMRCPPIDSQSKSFLSSTALLRYPPPFHFLPDQVRSRTPPDITQYSSLYDSSNLRRQRGEKKPIPDEQKDDKYYERRRRNNQAAKKSRDARKMREDQIALRATILEHENAILRAQVLTLREEASSLRQMLLQKKAIELASRDSQICIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJZ3</accession>
    <name>A0A6P7FJZ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114331037</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028136301.1">
        <property type="nucleotide sequence ID" value="XM_028280500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJZ3"/>
    <dbReference type="FunCoup" id="A0A6P7FJZ3">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280500.2">
        <property type="protein sequence ID" value="XP_028136301.1"/>
        <property type="gene ID" value="LOC114331037"/>
    </dbReference>
    <dbReference type="GeneID" id="114331037"/>
    <dbReference type="KEGG" id="dvv:114331037"/>
    <dbReference type="InParanoid" id="A0A6P7FJZ3"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="73"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028136301.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="34326" checksum="AEEA245ABCD40BD2" modified="2020-12-02" version="1">MNSSKIYSVFTYRNLFWKRKKSYFGKYNVVSPGNVSPMLTVPEEIEKPSYSSSGKPGPSPDFAEIKNVHQIHKMMDSCKLAADILKKVENIIKVGIKTDEIDIFVFNSCLANNAYPSPLNYNNFPKSVCTSINNVACHGIPDDRPLEDGDIINVDITVYYNGYHGDCSKTFLVGNVDDEGKQLVEATKVCLNEAISICKPGTYFRDIGFCIQEKAEKLGFQIIPSFIGHGIGSYFHGPPDIYHMKNNYPGRMESGMTFTIEPILTQGDQYIVILDDNWTAITEDNARTAQFEHTVAITDTGVEILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJZ4</accession>
    <name>A0A6P7FJZ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Achaete-scute complex protein T3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114330215</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135337.1">
        <property type="nucleotide sequence ID" value="XM_028279536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279536.2">
        <property type="protein sequence ID" value="XP_028135337.1"/>
        <property type="gene ID" value="LOC114330215"/>
    </dbReference>
    <dbReference type="GeneID" id="114330215"/>
    <dbReference type="KEGG" id="dvv:114330215"/>
    <dbReference type="CTD" id="30985"/>
    <dbReference type="InParanoid" id="A0A6P7FJZ4"/>
    <dbReference type="OrthoDB" id="5976910at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19744">
        <property type="entry name" value="bHLH_TS_dAS-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF108">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028135337.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38943" checksum="A8F2451ED4DBD3EF" modified="2020-12-02" version="1">MSQISVVQYNPPLNKLNILQQTNVNNKQSERQIIVLRKPPQLLPQPKDFNRDEVLITNTAKKKPASKPAKELKTNPAPVSVARRNARERNRVKQVNNGFANLRQHIPNFIAAAFESSNGRGGNKKLSKVETLRMAVEYIRSLEDILAMDSTDGIPEHPYPSPTSSVSPNHPMTNNVTYTYQILSPPDDDDDVSSTATSSPQQFIKIDTSSGAFQVLSNTIYEDDENLDPMVDEHLLTDPSLLDPNLPFNVNAQDLSYLNNMHTTGSLSPGIYSDSSLSPGSLEKSDPNCYISVFNNSREEQLCDVKPNINELPVMHLKTENGLTEEHKENIEDVLQWWEQRPQPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FL86</accession>
    <name>A0A6P7FL86_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329043</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329043</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133855.1">
        <property type="nucleotide sequence ID" value="XM_028278054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FL86"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278054.2">
        <property type="protein sequence ID" value="XP_028133855.1"/>
        <property type="gene ID" value="LOC114329043"/>
    </dbReference>
    <dbReference type="GeneID" id="114329043"/>
    <dbReference type="KEGG" id="dvv:114329043"/>
    <dbReference type="InParanoid" id="A0A6P7FL86"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027775244" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133855.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12982" checksum="32FCE67FBFD625D2" modified="2020-12-02" version="1">MKSIFIITFFACIGLAVTVAIPMNIKGPAPDLDDPNCVVCFSAGNFIQGFKNSGDSKEEAKQQRNFICNLFNTDELMQICMSTYEEDVEYIYGVTDLRTVTEMCIDMNKCKAKPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPB1</accession>
    <name>A0A6P7FPB1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC114329798</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028134817.1">
        <property type="nucleotide sequence ID" value="XM_028279016.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028134818.1">
        <property type="nucleotide sequence ID" value="XM_028279017.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518437.1">
        <property type="nucleotide sequence ID" value="XM_050662480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279017.2">
        <property type="protein sequence ID" value="XP_028134818.1"/>
        <property type="gene ID" value="LOC114329798"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662480.1">
        <property type="protein sequence ID" value="XP_050518437.1"/>
        <property type="gene ID" value="LOC114329798"/>
    </dbReference>
    <dbReference type="GeneID" id="114329798"/>
    <dbReference type="KEGG" id="dvv:114329798"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028134817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134818.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14001" checksum="A86D127A6BDF7369" modified="2020-12-02" version="1">MFKSLISSLQPSKMVIILRTDINMGRGKLASQAAHAAVLLYQSSIESNNLHLKSWLATGQPKIVLKVETNCEEVLKDTYNKAKNLNLNTCLVRDAGRTQVDVACLTAVGIGPNKKSDIDEITSSFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRR4</accession>
    <name>A0A6P7FRR4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114333305</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with ALKBH4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138966.1">
        <property type="nucleotide sequence ID" value="XM_028283165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRR4"/>
    <dbReference type="FunCoup" id="A0A6P7FRR4">
        <property type="interactions" value="1368"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642076.1">
        <property type="protein sequence ID" value="XP_050498033.1"/>
        <property type="gene ID" value="LOC126879123"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FRR4"/>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000020">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="12">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028138966.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27424" checksum="D6AD6C7B85B2807C" modified="2020-12-02" version="1">MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQAGPTSVAVRGVDAAACVTQRKIPDKLIDPNTITHLFQLTEHTGCVMTGMIADSKSQVQRARYEAAEFKYKFGYEMPIDALCRRVSDISQVYTQNAEMRPLGCSMLLIGYDQEMGPCVYKADPAGYYCGYRAVSVGSKQTEANSYLEKKLKKKTDLSKDEVIQLAISCLSSVLSVDFKPTEVEVGVVTKDEPKFRKLTEQEIDFHLTAIAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVG3</accession>
    <name>A0A6P7FVG3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl farnesoate epoxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114334611</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140489.1">
        <property type="nucleotide sequence ID" value="XM_028284688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVG3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284688.2">
        <property type="protein sequence ID" value="XP_028140489.1"/>
        <property type="gene ID" value="LOC114334611"/>
    </dbReference>
    <dbReference type="GeneID" id="114334611"/>
    <dbReference type="KEGG" id="dvv:114334611"/>
    <dbReference type="InParanoid" id="A0A6P7FVG3"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20651">
        <property type="entry name" value="CYP15A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028140489.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="57776" checksum="4156F3973243A24A" modified="2020-12-02" version="1">MLFSVVCLIITVFAMVLLYDMRRPRKYPPGPNFIPIVGSYLHYRERLKALGYHHLVWMELFQKYGEVVGMKLGRNYVVGVFGSEAIKEVLSREDFDGRPDGFFFRLRTFGKRLGIVFSDGQFWQNQRKFSIQHLRNFGFGRREMEEKIHEETRALIEHFKKNDSEPVFMHNAFDISVLNALWAMMAGQRFETDDERLRRLLQIIHDAFRLVDISGGLLNQMPFLRYVAPDACGYTQIRNILERMWDFLEETIAEHRKTFTDSQQPRDLIDAFLQKIDVKSDPTFTDDQLMSLCLDLFMAGAETTSNTLGFAMMATVLYPDLQRKIQTEMDKEVGRNRWPSLNDRIRLKYTEAFLMELQRRVTIAPLGIAHRAVRDTDLYGYLIPEDTIILTNLFSVHMDESYWKDPYEFRPERFLTDEGDIFVDDKHYIPFGSGKRRCLGESLGKANIFLFFTAILHNFYLVKADDNELKLEGYDGVTMAPKPFRVRLIARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWC3</accession>
    <name>A0A6P7FWC3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC114333426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC114333426</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139097.1">
        <property type="nucleotide sequence ID" value="XM_028283296.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028139098.1">
        <property type="nucleotide sequence ID" value="XM_028283297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283296.2">
        <property type="protein sequence ID" value="XP_028139097.1"/>
        <property type="gene ID" value="LOC114333426"/>
    </dbReference>
    <dbReference type="GeneID" id="114333426"/>
    <dbReference type="KEGG" id="dvv:114333426"/>
    <dbReference type="OrthoDB" id="6605214at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029159">
        <property type="entry name" value="CA109-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15011">
        <property type="entry name" value="CA109-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028139097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028139098.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24121" checksum="9D444F20B4FBED32" modified="2020-12-02" version="1">MTMTTQIDREAFFLTLQKNLLNFCKLLPSHVDKWRNLLNEAEKPVQALVNFSEQLRHVEKANISYLEDFKVLQDKLMYKIFSEIEDEIASIRGIIDRLHTANQEVKNKLSILEKSTVDLDWDEETPLIRGTAFQPPLSRILQEGYNYVLFFTSALKSFNDNMKVLNIRNEHFMKIFENKFKIDLESKVVINYLAIVQYIGNEKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX66</accession>
    <name>A0A6P7FX66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114333656</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028139392.1">
        <property type="nucleotide sequence ID" value="XM_028283591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX66"/>
    <dbReference type="FunCoup" id="A0A6P7FX66">
        <property type="interactions" value="1787"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283591.2">
        <property type="protein sequence ID" value="XP_028139392.1"/>
        <property type="gene ID" value="LOC114333656"/>
    </dbReference>
    <dbReference type="GeneID" id="114333656"/>
    <dbReference type="KEGG" id="dvv:114333656"/>
    <dbReference type="InParanoid" id="A0A6P7FX66"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="704"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028139392.1"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122492" checksum="B668BD091D1E0044" modified="2020-12-02" version="1">MFHKAENSKGNFLEQTKAAREERALEKKREAAAKIIQAHVRGWLCRIRFTRNILQDFDEAIPHTPEDVSKIQYKPANEIFHHALKLLFVWKKERDKERFAKLCRYLVATLNSDSLKISYVGVAFNKQTVIRWISHMNEILWNCCGYLNDLKPELSGDMKSIVMYLHLLVSFTSTNTWVVLKNKNMEMFWSGMNQLCANLMGQLFHKGFYLVLKNLLLRGLARTKISFKHVSLSAILTLSLRPLVAANYSDKLMTIFLINIFSVPGLVKHLQNLSSECISTLGNHKIFPRSLELLSSQQSMRIVFNTLEGSYALCLLANLIQMAYIERNSTLRELCFPTFTVVVTGLLESCQNYVVSKQSTLTHWHPVLGWFAQPMDMFLLTAIPHVKEQLHYLWNTEIIQILLGDPLSTLVADTEPPVQIMSPTQMSVGGTSFFKKVLESKGTKPAIQKTYRALGSPEVHRIVLICSLYHTALNTLTQLQLDILTGLCYQNTVLYNLWLFLCSLGPNCGIKPFLDHLAFNTKCSAPEFQLLQLFSDCMLHYVTILDDMEMYEQQNPFRLSDFIVMSNFLNIFLYKAVLGNLFDFKTIHNNSLFSSLHAILMLLYKRDCRRSYTPSGHWLIKDIKVSVFIADLEKGRRAPQLLLQTMPHVIPHDDRVRLFRKYITNEKTVLGLTESVCASPQSTLITVHRNRIVEDGYRQLAMLPSQSLKGVIRVRFINEQGLDEAGIDQDGVFKEFLEESIKKVFDPSLNLFKATSEERLYPSPTSAVQDNHLQLFEFVGRMLGKAVYEGIVVDVPFASFFLSQISGQTTQLLYSCVDELPSLDPELYRSLNYVKHYKGDVSELDLTFSVDEDSMGKIVTHELVPGGKAVQVTNENKINYIHLMAHFRMHLQIKDQTASFIKGFRSIINPDWLTLFSTPELQRLISGDNVPLDLKDLRKNCQYYGGFHDSHRVIGWLWDILEKDFNEEEKTMFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVGDDEDTGDTIGSVFRGFFTIRKKDPQNRLPTSSTCFNLLKLPNYQKKSTLREKLRYAVTCNTGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZ93</accession>
    <name>A0A6P7FZ93_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD, quinone]-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114335815</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141904.1">
        <property type="nucleotide sequence ID" value="XM_028286103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZ93"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286103.2">
        <property type="protein sequence ID" value="XP_028141904.1"/>
        <property type="gene ID" value="LOC114335815"/>
    </dbReference>
    <dbReference type="GeneID" id="114335815"/>
    <dbReference type="KEGG" id="dvv:114335815"/>
    <dbReference type="InParanoid" id="A0A6P7FZ93"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027939405" evidence="4">
        <location>
            <begin position="20"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141904.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="70522" checksum="527737A33823C7C9" modified="2020-12-02" version="1">MKQLVCIILLSTYCVLTKGVLTKCSEENEIQYYEKLVTRSRKDALTTVLSTNAKEYQTKNQIVHDYGEYDFIIVGSGSAGSVLANRLSEVDQWRILVLEAGDFGNDETDMPGLYVDLPFTDYNWGFKTQPQQNACLGMVNKQCMFPRGKGFGGTSLINMLVYSRGSSLDFDKWAEVVQDSRWSYNSVLPYFIKSEKFNHRDQKAPVNWTVHGTNGLLNVEYHLPRNPQADAFIEANREIREPIADYNGGTGLGASVYQTTTISGKRDDTGKAFLQPFLKRKNLKLRKYSYVTKILINRKDKRAEGVVFSCRRTKKQYIVRASREVIISAGAVQTPQLLMLSGIGPKQHLKSLKIPVVEDLEVGSKLRDHPLAFVINFSTTNYSAPIRPLRDDVVDYLKGVGPLTSQGNSLAVGFYESSYTKGSGLPDIELIMYVSNATGPTSQKLFGLSDQSYSETWKNVNVTTNCLILAVALHTASTGSIRLKSSDPYEYPLIDPRFLSDPKGEDIEKLYEGLMLSIKLIKTKAFQKMGAKIDKRPLTACESFEYASKDYWMCAIRQLSTDVYHPTSTCPMGPYPGKGDVVDSVCRVHGIKRLRVVDASVFPFTLAGHPNAPVIMVAEVISNAIKKEYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZA3</accession>
    <name>A0A6P7FZA3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal 1 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PTS1-BP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114335773</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141866.1">
        <property type="nucleotide sequence ID" value="XM_028286065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498568.1">
        <property type="nucleotide sequence ID" value="XM_050642611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZA3"/>
    <dbReference type="FunCoup" id="A0A6P7FZA3">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642611.1">
        <property type="protein sequence ID" value="XP_050498568.1"/>
        <property type="gene ID" value="LOC114335773"/>
    </dbReference>
    <dbReference type="GeneID" id="114335773"/>
    <dbReference type="KEGG" id="dvv:114335773"/>
    <dbReference type="InParanoid" id="A0A6P7FZA3"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000034">
        <property type="entry name" value="Peroxisomal biogenesis factor 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028141866.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66063" checksum="D6E507358F16DCD2" modified="2020-12-02" version="1">MAFRPLTEAECGQANPLTKLTSHITRDHTFSDNHGQVFQSSSDQLVEQFLQETRAIPQSYRMDDLMREMHEIESQRSALPPIPASTVKDQLHDNAWALQYIEDGKRFNEVYNNENVWAEIMSQEQRQHEFQRLADTWASQGLEGPLDASELFSQEDNLEDSKYVYSKFMKFMKEEGNDSKIEEGKLTEQEAAQWTKEYFDTDEKPATKVETVAQEWSEELEEGFVDDREFNSAFWDKLQEDMKKVSETDVDPSQPWIDEFNNYYNMTTKEYDFSEENPMSDIPQPLERGKQFLAEGDFPSAVLCFEAAAKQEPQNAEAWLLLGTTQAENEQDPSAIPALNRCLLLDNSNLKALMALAVSYTNESYYNQACQMLLNWLKFNPKYQELVPPNLKLSGQVTSLLVQNDHKIIQDLFIKAAQRNPQQIDYEVQCGLGVLFNLTGEYNKAADCFTAALSVKPDDARLWNRLGATLANGSRPEEAVDAYHHSLNLSPGFIRARYNVGITCINLNAYREAAEHFLTALNQQARGKDVVNSGSMSQMSDTIWSTLRMCISLMNRGDLKHLVDKRDLKELNKAFGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0Y2</accession>
    <name>A0A6P7G0Y2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114333101</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114333101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138733.1">
        <property type="nucleotide sequence ID" value="XM_028282932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0Y2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282932.2">
        <property type="protein sequence ID" value="XP_028138733.1"/>
        <property type="gene ID" value="LOC114333101"/>
    </dbReference>
    <dbReference type="GeneID" id="114333101"/>
    <dbReference type="KEGG" id="dvv:114333101"/>
    <dbReference type="InParanoid" id="A0A6P7G0Y2"/>
    <dbReference type="OrthoDB" id="6779030at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028138733.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31336" checksum="B77C6833278035D7" modified="2020-12-02" version="1">MSLATFHDFCNNVYQCAEKLGDEIETNINYSQNLITTNETIDVKLPLEKVKLYHYCEIIKLLQNVKRDVKKILYHEKSINTLISTKKLSGEEIKHYFSVENVNERKSTEYFIRQERRRKASQVSLYTLSTWEAYLKNKEQEEAAIPEASIEASAVPKRTAPKSKRKQKKFVSSTFNDILENVDTDIESNCKSIVEENEDEDDVGYDIKLSKQFQSYSENNLTEMVESSELRSCVSVDNFGPTKPKIVDVLYKKPPVTEMGLIQKIFYPNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2F2</accession>
    <name>A0A6P7G2F2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ADP-ribosylation factor-like protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114336941</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143129.1">
        <property type="nucleotide sequence ID" value="XM_028287328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2F2"/>
    <dbReference type="FunCoup" id="A0A6P7G2F2">
        <property type="interactions" value="1658"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655034.1">
        <property type="protein sequence ID" value="XP_050510991.1"/>
        <property type="gene ID" value="LOC126887478"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G2F2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903292">
        <property type="term" value="P:protein localization to Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000294">
        <property type="entry name" value="ADP-ribosylation factor-like protein 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028143129.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20258" checksum="3A681B8C9434E444" modified="2020-12-02" version="1">MGLLFAKLWSLFGNEEHKIVIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEVVWRNIHFIMWDLGGQQSLRAAWSTYYTNTEFVIVVVDSTDKERLSVIREELYKMLANEELSKAGVLVYANKQDVKGSMSASEISKELDLTSIKQQQWHIQSCCALTGAGLYPGLEWIVSRLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4C1</accession>
    <name>A0A6P7G4C1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114337572</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_028143849.1">
        <property type="nucleotide sequence ID" value="XM_028288048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4C1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644104.1">
        <property type="protein sequence ID" value="XP_050500061.1"/>
        <property type="gene ID" value="LOC126880306"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644106.1">
        <property type="protein sequence ID" value="XP_050500063.1"/>
        <property type="gene ID" value="LOC126880308"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G4C1"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028043797" description="Cellulase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="11">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028143849.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="25664" checksum="CB44D900A763A3BC" modified="2020-12-02" version="1">MKIAILVSALVALAVATPLEQSPEIKFIEKGISGEGTTTRYWDCCKPSCSWRGNVHTPSGVPVASCDRSGVNRVDDNAKSGCEGGGSAYMCNSQQPWAVNSTLAYGFGAASFSNGIDVSLCCACFLLSFKDQISNKKMIVQVTNTGSDLSHNHFDIALPGGGVGIFTQGCHDQWNAPWNGWGDQYGGVHNRGECATLPQALQSGCYFRFDFYQNANNPRMHFDQVQCPAEIVARSGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8T2</accession>
    <name>A0A6P7G8T2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114337103</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143287.1">
        <property type="nucleotide sequence ID" value="XM_028287486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8T2"/>
    <dbReference type="FunCoup" id="A0A6P7G8T2">
        <property type="interactions" value="1338"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642821.1">
        <property type="protein sequence ID" value="XP_050498778.1"/>
        <property type="gene ID" value="LOC126879637"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G8T2"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000103">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="4 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="11">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028143287.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45594" checksum="3A9BAD9985E16737" modified="2020-12-02" version="1">MLYLEDYLEMIEHLPQELRDRFTDMREMDLTIHNNMDELEKRVKNFFSDCKRCPNDLPQSVEAEFQGIRKEYYKTLEEADEKVHLASQMYDLVDKYLRRLDSELHKFKCELEADNKGITEVLEKRSLELDTPNTTPNISSLQQKENRYDSAFRYSRPRAEKRRDSSVSIPAQLTEKRQAVTPVAPPPLIETRHATTSVQPIAPSSATTTTMSYNLGHNLGAGPAIAAAASQAIAATQQMQQGRRTASLKASYEAINTGVHGHEFGIGRELAGAAQTAIQAIQQDHANNKKKQKKWNSSSSSSTSTATVVQPVVSTPVVIPPHESPTVDTNSQNAEVTDGEWTYDPNEPRYCLCNQVSYGDMVACDNEDCPSEWFHYPCVGITAPPKGKWYCPQCTASMKRRGGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G918</accession>
    <name>A0A6P7G918_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114335025</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028140980.1">
        <property type="nucleotide sequence ID" value="XM_028285179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G918"/>
    <dbReference type="FunCoup" id="A0A6P7G918">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285179.2">
        <property type="protein sequence ID" value="XP_028140980.1"/>
        <property type="gene ID" value="LOC114335025"/>
    </dbReference>
    <dbReference type="GeneID" id="114335025"/>
    <dbReference type="KEGG" id="dvv:114335025"/>
    <dbReference type="InParanoid" id="A0A6P7G918"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="46"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028140980.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29515" checksum="8E6B4F447641C0B2" modified="2020-12-02" version="1">MTTLPFSFQIQEKFEKLSFRYGTQISEDSAISSCSTPSTPTSPIDFEIKIATLDDKEAVQEFLQKFFYKDEPLNSFMEIITDEHPRCYDLERFTLKNLDNGVNLLAVQNQKIIGVCLNGNQVSLSDVIERGVIEEDFICDDEKFGKIVKLLEHVAVESDPFQIYPGIDMAMVVKILSVDGSYRGKGIAKDLMAKTRELARLKGCGFITVDCTSHYTACAAKKLGFELHYTLNYADYKVADKVVFKPEPPHKALTVYTQKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GC38</accession>
    <name>A0A6P7GC38_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335776</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141870.1">
        <property type="nucleotide sequence ID" value="XM_028286069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GC38"/>
    <dbReference type="FunCoup" id="A0A6P7GC38">
        <property type="interactions" value="2116"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286069.2">
        <property type="protein sequence ID" value="XP_028141870.1"/>
        <property type="gene ID" value="LOC114335776"/>
    </dbReference>
    <dbReference type="GeneID" id="114335776"/>
    <dbReference type="KEGG" id="dvv:114335776"/>
    <dbReference type="CTD" id="4958"/>
    <dbReference type="InParanoid" id="A0A6P7GC38"/>
    <dbReference type="OrthoDB" id="69088at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040316">
        <property type="entry name" value="INTS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029444">
        <property type="entry name" value="INTS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029445">
        <property type="entry name" value="INTS5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31697:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14838">
        <property type="entry name" value="INTS5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14837">
        <property type="entry name" value="INTS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 5 N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="240"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141870.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="107065" checksum="A7EF7CA1B51DE88A" modified="2020-12-02" version="1">MSQSTSTGAGAATVVRTAPQQDLMNELNFFLKGASRKEPYSQVDLTKSALTLLKCLPPTKDAVFEYFRGVFETAAKSYVQRLETEINTGKLPPPSEIDELMVSEIHTVLSNIIADNPVVWAPTISTWSLELLGEISTKYCGRAHFSSNLNETLQLWMGCRATRTLMDINTKCLSSLIHSNTEACISALLDTSVKHSPNFDWVVAHVGSCFPNTVITRVLSVGLKDFCQNKSYEQGSNSPKLKSVVGILGHLAGSHAEDIRKALLDIFTASICENVRDTDISRLQKKATVPYILQLIHLSSTLLSSICQDIKQFLTTDTITRLYHFVEDWCRYFGTPEALQEILIGLILRCETGGDQIIMLMLDCILITKTEEEIKSNIVETSKELLTTVLQDMEESVRHNNAVDLINSFSKEIPQLVQMLLSSEKIVSDTAAKIVLLLGHTNPSILVTVLQSLLKSSTTDNQLVILLKFLTSDLIDKTVLPYSEKGGHFSLVLEEILNRNVQKFCTSNEENLDLSLMWNNLLKLLRWEKSGKVPLLNSKIITRSLQANLPSLTALFSNEVLHMHVIADILDAIEIPVQNGPYNPPIEVVLNLTQSTVNYFFQCCKDDGTALKLKGYKKANTMLKRLCTYSKVAKVLALRELLERALFRADNVLFGAKNNEMGNENEKYLLKQNKKINKTIPLTKHSTVFNGGIIGTGKRKSICYDRFPTHVISDNIAQLINAIKACCALPEEHKYTDMSWDSMTLLSLLLVQFVSPDVMYNGLPWPEEEFSKVTMERDLFIRRMFSNTPLLWDLLSFVAVYRPAICYCSVLIRALTATLIHQWKSMGEQSKDDDSEHYKNLMDTTIRVIDVMALGQLLPPPLSSTRDVLPYLKCYEIVAVLRECIWCYMRDHIPSPALFACDSNGVHWRDPVNARPPEVYTNTLRIIMQRNIKSLGHMYAQMFINVPTHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDV9</accession>
    <name>A0A6P7GDV9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable nuclear hormone receptor HR38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor subfamily 4 group A member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114336199</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms a heterodimer with USP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142330.1">
        <property type="nucleotide sequence ID" value="XM_028286529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDV9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286529.2">
        <property type="protein sequence ID" value="XP_028142330.1"/>
        <property type="gene ID" value="LOC114336199"/>
    </dbReference>
    <dbReference type="GeneID" id="114336199"/>
    <dbReference type="KEGG" id="dvv:114336199"/>
    <dbReference type="CTD" id="35332"/>
    <dbReference type="InParanoid" id="A0A6P7GDV9"/>
    <dbReference type="OrthoDB" id="5952118at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06969">
        <property type="entry name" value="NR_DBD_NGFI-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07072">
        <property type="entry name" value="NR_LBD_DHR38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000009">
        <property type="entry name" value="nuclear receptor subfamily 4 group A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003070">
        <property type="entry name" value="NR4A1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF4">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01284">
        <property type="entry name" value="NUCLEARECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="266"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="365"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028142330.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="67004" checksum="A95881C3ECED32AF" modified="2020-12-02" version="1">MRSGPPVIKIRASGFHRFQRYHYSREGGVDANNNNADYINGLPNKCTLLVQSEVSNTPLVAESAQPSAPSSPHSSMLLLQSQTPFGPSSFADLLNAPFSDDPTSTVTSEELNPFADVALHSQPSSPLPLPSFQETYSVRYQSPFKMDEDCFNISYQQHPHHYDYSQQQYTAASPYYPPPPSFDAHISQESYSLPVYPSSELHITTSLSSKSRRASLPLQRSESTSSSESPKLRIGPAPSTCSSASSSPGGIPEQISVKGPTPPSPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLADKACPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQESPPSPPVSLITALVRAHVDTTPDLANLDYSQYLEPSPIEPIVSEAEKIQQFYTLLTTSVDVIRHFADKIPGFQDIRLEDRELLFQSASLELFVLRLAYRTHPNDSKLTFCNGVVLDMQQCHRSFGDWLNSIMEFCAGLNGMEIDISAFACLCALTLITERHGLKDPHKVEQLQMKIISSLRDHVTYNAEAQRKSHYFSRLLGKLPELRSLSVQGLQRIFYLKLEDLVPAPPLIEKMFVASLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GE40</accession>
    <name>A0A6P7GE40_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC114341206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114341206</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM174 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147799.1">
        <property type="nucleotide sequence ID" value="XM_028291998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GE40"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645175.1">
        <property type="protein sequence ID" value="XP_050501132.1"/>
        <property type="gene ID" value="LOC126881120"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GE40"/>
    <dbReference type="OrthoDB" id="5917722at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009565">
        <property type="entry name" value="FAM174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06679">
        <property type="entry name" value="DUF1180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027595090" evidence="10">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028147799.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19701" checksum="E5AE0A384824C74B" modified="2020-12-02" version="1">MSINLFLYLLMFSSAICLTKGTSVERIPKKSAQSDNTDTNKETHKEPAVQISAKPAKPVTHSDSSSSVKKDSVKQTPHNQTTSVTKAEKVLDGNNDVPESNSAQAESGAVIRGVLVFGGLGLIFLIYVGVRTYRRRKMPIIRKYGVRARRSDVEMRPLPLDDDEEDETVFDLSHLNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEH9</accession>
    <name>A0A6P7GEH9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC114336356</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028142509.1">
        <property type="nucleotide sequence ID" value="XM_028286708.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028142510.1">
        <property type="nucleotide sequence ID" value="XM_028286709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEH9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286708.2">
        <property type="protein sequence ID" value="XP_028142509.1"/>
        <property type="gene ID" value="LOC114336356"/>
    </dbReference>
    <dbReference type="GeneID" id="114336356"/>
    <dbReference type="KEGG" id="dvv:114336356"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028142509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028142510.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21905" checksum="1207DAC541209C38" modified="2020-12-02" version="1">MPVPSLQKPAPVFKGTAVVNGMFKDISLEDYKGQYVVLFFYPLDFTFVCPTEIIAFSDRFEEFKKINTAVVACSTDSQFSHLAWINTPRKQGGLGEMAIPLLSDKSGAVAKAYGVLDEETGIPFRGLFIIDGKGNLRQITINDLPVGRSIDETLRLVQAFQFTDEHGEVCPVGWKPGQKTMKPDPTGSKDYFSTVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIA8</accession>
    <name>A0A6P7GIA8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114343018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114343018</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149631.1">
        <property type="nucleotide sequence ID" value="XM_028293830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648000.1">
        <property type="protein sequence ID" value="XP_050503957.1"/>
        <property type="gene ID" value="LOC126882923"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIA8"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113">
        <property type="entry name" value="AGAP001705-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113:SF14">
        <property type="entry name" value="LP24064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028149631.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23464" checksum="C11053C17ED312A8" modified="2020-12-02" version="1">MTLKVVLYFGMYLIAEISGHGMMLNPPGRSSFWRFNDTAPRNFDDNQVFCGGAYVQNELNDGKCGVCGDPYTDPHPQRNENTGFYGIGIVVKTYEPGSVIDVKIMLTANHLGNFTYSLCELEDFDAPEPENCFEDLLLEDGSANYNVEWEDEVVFNKVRLPNFQCERCVLRWTYKAGNNWGLCEDGKWRRGCGPQEHFISCADIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNB4</accession>
    <name>A0A6P7GNB4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calphotin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340914</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147492.1">
        <property type="nucleotide sequence ID" value="XM_028291691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNB4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291691.1">
        <property type="protein sequence ID" value="XP_028147492.1"/>
        <property type="gene ID" value="LOC114340914"/>
    </dbReference>
    <dbReference type="GeneID" id="114340914"/>
    <dbReference type="KEGG" id="dvv:114340914"/>
    <dbReference type="InParanoid" id="A0A6P7GNB4"/>
    <dbReference type="OrthoDB" id="6770654at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028036841" evidence="1">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147492.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38185" checksum="BDCB25FA79C14B5A" modified="2020-12-02" version="1">MKTFLILSCVALAVIAAPGAKDAKSSEKSKRHLGENYYYFDSLPQTYSAPLQLDNTVLLSNSAQVAQAAPVAQFYSAPVVRHEVAQQIAPVAQFYSAPVVREEVAQHTVHNVINKVPVAIAQPVAVPITKTVKVAQPYPVTVEKPLPVQVRVNVPYPVEKPYPVHVPHQVPYQVKVKVPYAVEKPYPVTITKTVPVAVEKPVYVKVPEIVKVPVAQPYPVAVQRKVAVTVPEPHVVKVPELINVHHKVYKQPVVQQQVVEQISLPVYSQQVYGQEYGLSSGLQSGYQSGYQSGLQSAQIISGEFLETEQAPPCPLTQGHNKNSFGSNFGSYGKHSIFARNTEKNAQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQP0</accession>
    <name>A0A6P7GQP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease P protein subunit p29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114341741</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148357.1">
        <property type="nucleotide sequence ID" value="XM_028292556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQP0"/>
    <dbReference type="FunCoup" id="A0A6P7GQP0">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647160.1">
        <property type="protein sequence ID" value="XP_050503117.1"/>
        <property type="gene ID" value="LOC126882296"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQP0"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028148357.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26393" checksum="4890692DC0C53D8A" modified="2020-12-02" version="1">MNRTDLKELLHSDLPNEIIQLPSVSTEDSLEYVKHFLSQNLPSSDSKNLTTDLKWNFLLEKHSLEKRKTGFKGKKSFLTRKQRKDLNLLKVPREGWDYVQLENLRDMWRSYMRENLDLNRMAPSCTDQDWNAFSVIVAKSELIGAEITVVRSKVPSLLRMKGTIALETKMTFQVVTAESKLKILIKADSVFEFQLDNIKFTVFGKYLMTKPSERSTKKIRSQMTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR88</accession>
    <name>A0A6P7GR88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114339822</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028146310.1">
        <property type="nucleotide sequence ID" value="XM_028290509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR88"/>
    <dbReference type="FunCoup" id="A0A6P7GR88">
        <property type="interactions" value="1442"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290509.2">
        <property type="protein sequence ID" value="XP_028146310.1"/>
        <property type="gene ID" value="LOC114339822"/>
    </dbReference>
    <dbReference type="GeneID" id="114339822"/>
    <dbReference type="KEGG" id="dvv:114339822"/>
    <dbReference type="CTD" id="38581"/>
    <dbReference type="InParanoid" id="A0A6P7GR88"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000060">
        <property type="entry name" value="Leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000100">
        <property type="entry name" value="probable leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="42"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="373"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="738"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028146310.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="101814" checksum="177B824858BA87E5" modified="2020-12-02" version="1">MFTIKKCFLPHKTLQRIVSYRCLSGLNLWDQEISSEIKHEIEKHWKDKLKFKSFEDSSSNKEKYYVLSMFPYPSGALHMGHVRVYTISDTVARYQRLNGKNVLHPIGWDAFGLPAENAAIDHKIAPDVWTKQNIAHMKEQLERLNCSFEWNREFKTCDPNYYKWTQDLFLKLYDEGLVYQKEALVNWDPVDQTVLADEQVDENGNSWRSGAKVEKRVLKQWYVRTTRFAKNLLDGLNDPILQDWRDIIKLQKHWIGDCDGVNFDFTIEGNNKEFLTLWTSTPEYVENVKFVAVTSDNILAKKEGVKLKGEEESVRLRTHLINPINCEKIPVYVTNEVEFLPLTDSYIGIPGILEEATNFARKHSITFENVQLLEEPVLEQKRNNIINKARELKVGGYWTSAKLRDWLISRQRYWGTPIPIVHCKSCGPQPVPRKDLPVILPELKHESQKSGSQLAELSGWLNTTCPKCGGTATRETDTMDTFVDSSWYFLRFPDPHNEKEIFSKEAIDKVAPVDLYIGGKEHAVLHMYYARFIMHFLHSLGLVPEKEPFKRLLVQGMVMGRSYRIKGTGRYVRENEVKILDLKRNKAITKDTNEPVIISWEKMSKSKYNGVDPEDMFREYGTDTTRLLVLADVAPTSHRNWNNNTFPGVLNWQRRLWLTMQEFLKHRNTLPLPLPEAQFKIHDTYMYDSRNYYVKGVSYNYLITQQISVAVSKQQGLTNSLRRVPPSIIAHSRQFERAFGAQIIMLAPMAPCFASELWSGFTSAPNRLNTSEFLWDTSVFEQDWPVTDMDYMLELICQVNGHENAVLKMSRQQLEDLSKDAAYKLALEQKEVQSTLRTRNILDSNFTLRTGFEAILNLITDHPPPKAKITELEEARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZF7</accession>
    <name>A0A6P7GZF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114348397</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154779.1">
        <property type="nucleotide sequence ID" value="XM_028298978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZF7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050660958.1">
        <property type="protein sequence ID" value="XP_050516915.1"/>
        <property type="gene ID" value="LOC126891696"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GZF7"/>
    <dbReference type="OrthoDB" id="6501026at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028154779.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15039" checksum="78A37C762295D8F0" modified="2020-12-02" version="1">MSGRGKGGKNKADKYKSRSNRAGLQFPVGRIHRFLRRGNYAHRIGSGAPVYLSAVLEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKSGTGTAASGGKSTKSQSQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H079</accession>
    <name>A0A6P7H079_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114344497</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151133.1">
        <property type="nucleotide sequence ID" value="XM_028295332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H079"/>
    <dbReference type="FunCoup" id="A0A6P7H079">
        <property type="interactions" value="1631"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648370.1">
        <property type="protein sequence ID" value="XP_050504327.1"/>
        <property type="gene ID" value="LOC126883125"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H079"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028151133.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="64684" checksum="4EAD76673D2A710B" modified="2020-12-02" version="1">MSRNSLLSTLFPNEPTDELVYNPPIQDYLTKLGTYKIKDLNTEPDKLKQEALVLQEQIQELAITNYKTFIETALCSKDLFTKFSVIEDKVNDLLGGVPVFEEKCETFGEVSSKINALRRIDSITLAKSAQILEILEIPQLMTSFIRDGLYEDALELFNYVRKLSFKHSDVAIFKNINDDVNKAWILMLHQLLSQLRQDISLPKCLQIVGHLRRMDIFSEPELRLKFLQTRTYWLEQQLNSLGKEDPTVHLTKTIEVTRINLFNILTQYSAIFNDDERSPLTVASDKTINQPLIFKGWVQYQIGIFVKTLDSCLDNVTSFEMILDQCMYFGHSFSKVGCDFRHLLIPIFTKHIQKRFVNNVAKADRNFMKNIEKFTLIDKNNPSKSWKFNKDDTVRPPESLLEFYPLAEYLNNILAALNQLRLCPPIALIDEVVDTLQASMLLIAKCLQKLYSQEQQAFSVNSKDAFTRLCMCFSDDLVPFVQKCIHIIYPPSHIASKLGISLKNLQDTGTTFLDKQEIISPISHLLPVKIEPVVPVVETEVPAATDPEVLVVSDEVESKVDIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H459</accession>
    <name>A0A6P7H459_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114346721</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153307.1">
        <property type="nucleotide sequence ID" value="XM_028297506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H459"/>
    <dbReference type="EnsemblMetazoa" id="XM_028297506.2">
        <property type="protein sequence ID" value="XP_028153307.1"/>
        <property type="gene ID" value="LOC114346721"/>
    </dbReference>
    <dbReference type="GeneID" id="114346721"/>
    <dbReference type="KEGG" id="dvv:114346721"/>
    <dbReference type="InParanoid" id="A0A6P7H459"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028153307.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49800" checksum="234C1BFCD073E5EF" modified="2020-12-02" version="1">MRECISVHIGQAGVQIGNSTWELYCLEHGIKPDGTVEVTDQIVSDNCYGTFFSEVENGKLVPRAVMVDLEPTVVDEVRTGVYKKLYHPEQLITGKEDAANNYARGHYSIGKDMLDIVMERLNKLAENCHGLQGFFVFHSFGGGTGSGFSSLLMERLSNDYGKKSKLEFVVYPAPQVCTAVVEPYNSILTTNSTLDHSDCAFMVDNEAIYDICRRKLGIERPDYINLNRLISQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLASYAPVVSAEKAYHEGMSVAEITAELFEPTNQMVKCDPREGKYMACCLLYRGDVVPKDVNASIALMKAKSNVRFVDWCPTGFKVGINNQPPTVVKGGDLAPVQRAVCMLSNTTAIESAWKKLNKKFDLMFCKRAFVHWYIGEGMEDGEFGEARENLATLEMDYQEVASDSVDEENVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HD78</accession>
    <name>A0A6P7HD78_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Splicing factor 3A subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114347200</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153730.1">
        <property type="nucleotide sequence ID" value="XM_028297929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HD78"/>
    <dbReference type="FunCoup" id="A0A6P7HD78">
        <property type="interactions" value="2683"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644542.1">
        <property type="protein sequence ID" value="XP_050500499.1"/>
        <property type="gene ID" value="LOC126880584"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HD78"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028153730.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="58419" checksum="E83C4E1E7376E43D" modified="2020-12-02" version="1">METILEQQRRYHEEKERLIDAMVKEMLHKKTTFREAINSDHRQKYLLDRYMASTERLIDLYDDRDGQRKAEVAALTGPNEFQEFYSRLKLIKDFYRRHPNEISVPMSVEFDEFAKARENPNEDMANFVEFTDEEGYGKYLDLHECYEKYINLKGIEKVDYITYLGMFDQLYDIPKERKSGEYKKYLLCLIEYLTWFVQRIKPLKDLDIDLQEQVEQVLLNWDNGSVPGWPKETGSALTNVGAHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKGKGSLDPSLMTKNNKGKANKEKELLRQRELATLEAQVYRLAEWVSPQRAATKENVQRKQARTDGERDDSENEESEDDSPDEGDDDVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYNCEICGNYVYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDALALWEKLKVQKQSERWQPETEEEYEDSQGNVVNRKTYEDLKRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9G3</accession>
    <name>A0ABM5I9G3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acaloleptin A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127976.2">
        <property type="nucleotide sequence ID" value="XM_028272175.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272175.2">
        <property type="protein sequence ID" value="XP_028127976.2"/>
        <property type="gene ID" value="LOC114324365"/>
    </dbReference>
    <dbReference type="GeneID" id="114324365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009382">
        <property type="entry name" value="Coleoptericin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06286">
        <property type="entry name" value="Coleoptericin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045625754" description="Acaloleptin A-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127976.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57435" checksum="ABE19CBE0E37FD67" modified="2025-10-08" version="1">MKFTVTSLCLLLIAIVAVTNATGDKKKPQPWEVHPDVSGDGKNVNAGVEVKKNGENHDFEAGWNKVVHGPNKGKPTWHVGGTIRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFQAGWNKVVHGPNRAKPTWHVGGSFRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFQAGWNKVVHGPNRAKPTWHVGGSFRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFQAGWNKVVHGPNRAKPTWHVGGSFRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFQAGWNKVVHGPNRAKPTWHVGGSFRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFEAGWNKVVHGPNRAKPTWHVGGSFRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFQAGWNKVAHGPNRAKPTWHVGGSFRFKRSPKPDWEVQPGANGDGNGNTNAGVEVRNKGKDHDFQAGWNKVVHGPNRAKPTWHVGGSWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAJ0</accession>
    <name>A0ABM5IAJ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128602.2">
        <property type="nucleotide sequence ID" value="XM_028272801.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272801.2">
        <property type="protein sequence ID" value="XP_028128602.2"/>
        <property type="gene ID" value="LOC114324895"/>
    </dbReference>
    <dbReference type="GeneID" id="114324895"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF169">
        <property type="entry name" value="GH15759P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047121795" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128602.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36692" checksum="411690E08ED5CA2F" modified="2025-10-08" version="1">MFMRGMLNVTTLCALYALPGPAKIKIENKTFQSYSINRRLCPEIDPFRDTIFELYTRTNRKEAQILRTNNIAALKKSNIDYSRSTVIFFHGFMDSSHSNNAITFKDAYLHRGDYNIILVNNERLLAGMDYVTAVQNCKPIGQFSAKFIDFLLIQGLRLSSLHLIGMSLGAQIAGLTSKSMKSGKPQRVTGLDPAGLLFNSLPKSERISVGDGKFVDIIHTNAGFIGDDRAVGDLDIWVNGGMKQPGCFKQSANAPLLKYVFCSHSTSFRIYIKSLYEPKRFLITKCRNYPAYISGACSNGNTTYIGEYINQTLRGNFFINTMDTSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IBT7</accession>
    <name>A0ABM5IBT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Prosaposin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129404.2">
        <property type="nucleotide sequence ID" value="XM_028273603.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273603.2">
        <property type="protein sequence ID" value="XP_028129404.2"/>
        <property type="gene ID" value="LOC114325531"/>
    </dbReference>
    <dbReference type="GeneID" id="114325531"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00162">
        <property type="entry name" value="SAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046293512" description="Prosaposin" evidence="7">
        <location>
            <begin position="20"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="177"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="281"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="513"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="636"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="724"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="90425" checksum="EC17AF5F8DB54933" modified="2025-10-08" version="1">MVKMKILIIVAVFAAFASGVFVPPRPGHKKHLLGADLCTRGPGHWCQNLTTAADCHATKHCIQTVWIHQTLPPDDSSVCQICLDMVKQARDQLESNETQEEIKEVFEGSCALLYIKPIVKECDKLADDYIPDLIDTLASQMNPQVVCSVAGLCNNERVKKLLEEADDEPTTEVMPGKVDKCKGCHQVVDILDNKFNKMSRDEFLHGLLNFCGKFSSFSDGCSNLVITYFTEIYNHLQQHLNSEEVCLFSGECSAQFHAHRARVEITPNSHIGYVNVGDDKDDVPCQLCEQLVDHLRNLLVANTTEDEFKRVMEGLCKQTGKFSEECVELIDQYYGEVYTFLVDHLNATEVCDEIGICKASKEKEDLYIAPLLEKNNAEKALEISSERKPEKVDMSALSEVNLEQQLPIDLLMPPHTQILYNKELCAFCEYFLHYVQIALTDPKTETEIKSVIEKACKELPVSVNATCMSFVDMYEPALVALLDQAIDPSQVCPLIKVCPSSKSGIEVFMEAKSDSKCPLCLVAVTKLEEMVSNNKSVAQIKAALEKLCNVLPKSIDNQCEAFVDKYTDHIVDMLLADLTPEEVCVALKLCTDDRKVNSLPPYVVRQIGGNIETNVIPDNTVNGQIIVDIHTGSIGSKPECILCEFVMKEIEDQLNDKSTDAEIETVVKDICKIMPSSVRQDCDKFVDQYADTVIQLLIAALEPSKICSYIKLCAGSQMDMIKVQILECPVCEMTVEVMEKILSNPNVDHDIVHVIEKTCRGLPAKYRPQCIQIVEAYGKEMIDLIVHQGGKTVCRKFGYCKSSLGEVVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICC5</accession>
    <name>A0ABM5ICC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129722.2">
        <property type="nucleotide sequence ID" value="XM_028273921.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273921.2">
        <property type="protein sequence ID" value="XP_028129722.2"/>
        <property type="gene ID" value="LOC114325794"/>
    </dbReference>
    <dbReference type="GeneID" id="114325794"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF339">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045788739" description="Cadherin domain-containing protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="143"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="251"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="360"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="473"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129722.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="700" mass="77272" checksum="A1947E8CBEF9B2E4" modified="2025-10-08" version="1">MAKPDFEWNNRYILWILAILFHKSITALTDNRCFLENGASSENFFVAEDLPVGSIIGQIHVHGDPRVGGSIALRLKEKDSPVIITPGTKNLTLRKQLDKEGVKGPSSVFVNLICERVGTLDPGFVIPINVRVTDVNDNAPIFINAPYILNISEVTVVGTRVLQGVHAIDNDQQGLFSSVKYSVLPGQNSDFFEFENELEGTLVLKKPLDYESLKSFDVHIRAQDHGEPPKKTDTVLTVNVVDADDQNPKFQDDRYTAILPEPPKKGSILIIKPREIRAYDQDLGINSPVYYTFNEVGVEYTFFKLNRLAGKISLAKDLADNDIPYPVTLVIRATQQDNPDRYALATITVSRHIAKGIKFLHSTFYIKASESLPIGAVLGTVSNNRPGESLRYFVSDQNILKTFSLNTKGEITLKKKLDYEDKSEYYFKVFATDGITNDSSVVNISVDNVNEWEPRFRYPHYEFFISGSPEELLGKIEAADGDKNDKLTLSLSGANSSMFTISQNGELRLKDIKDVNVGMLSLAVVATDNGRPPKSSTVPVTVHFPDSADSSGISAGKKNNSASLLLAGLGAILLVLLFVVVLLVAYICKVKRNPRSDTSSLHSDKDKNGLKKITNPMFGDRSRTPTASAMGGIPSELRSKIPSPKVHPAPQPPLWANDCSRIKKLSWGDDKTETENNENIADVSPTPTTLHSNTNLTVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IM07</accession>
    <name>A0ABM5IM07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136071.2">
        <property type="nucleotide sequence ID" value="XM_028280270.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280270.2">
        <property type="protein sequence ID" value="XP_028136071.2"/>
        <property type="gene ID" value="LOC114330847"/>
    </dbReference>
    <dbReference type="GeneID" id="114330847"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136071.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="493" mass="54841" checksum="F73EDFBDE381E2B6" modified="2025-10-08" version="1">MVDSLDSNSRNNTLEELVNNSNRAPVDYTVQDARKKPDTAFLYFSTLTANLLLFSCSNFHVWTSPTLPKLLSNDTLINPVGRPINTLEVSLLAGFPFFVGLMGSIFSGTIADTVGRKSVMLYAAITVIMCSVTISASKDIYVYIVARCIIFVCYSSALVLVPLYLTEVCEDHNRAKFGCLMGISMPAGHLYSYVTGAKTSLPVYTLLCAAPLVLFLIAVLLFVPETPVYLIAKGKIKIALKVLEKLRRNKQQQEIERDFEKINDNYKTKRNSVTVSVVVLLKSKVNRKAIILAILPMWVQHLSGVTVIMQFMVPIFDEAGTNLSGTTVSVIAGTIKIIMFIITALFVEKTGRRPLLLLSGYGTGVSLFLLGLFLYWNHIKWQFLSHVVWLPILCLLLNLIVYSIGLGPIPMAVMSELFDSKFRPVALSFLVTLNGILVSALNFLFPILERNFGTHCCMWLFSICCFGGTTLIYFYLPETKGKSISEIQKLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INH8</accession>
    <name>A0ABM5INH8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137346.2">
        <property type="nucleotide sequence ID" value="XM_028281545.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281545.2">
        <property type="protein sequence ID" value="XP_028137346.2"/>
        <property type="gene ID" value="LOC114331865"/>
    </dbReference>
    <dbReference type="GeneID" id="114331865"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="3"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137346.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="529" mass="60115" checksum="E3F2E5E49D5D4763" modified="2025-10-08" version="1">MSGPIVTVKEGKLLGIQEKDDDGNQYYSFLGIPYAKPPIGELRFKAPQPPEKWEGIRDATKEGDECFSKQFQAYTGSEDCLILNVFTKEISSSKLRPVMFWIHGGGFTKGSNTLKLYGPDYLLREDVVLVTINYRLGPLGFMAFKDPDVGVPGNAGFKDAVMALRWVQNNIKQFSGDPNNVTIFGESAGAVAVHLLVLSPMTKGLFHKAILQSGCATSCWGTMNRIEPNLFAERAGIHSNDDNVILKHLKNMTLEELEATMEKTPELYPVGTLFPNGPVVETNSKEPAFLPSDPRDIVKSGNYNKVPMMMGCVSREGMFIYSIVAQENLVLVHETLLPRTLNLRIGSNLHTQAANKVKKFYFGDNDPLEDRDKIYKLYTDDYFLYEVYKNAREHLETNPYPIYFYRFLYDTELNFLKTFLNITDPGVSHADDCGYLFKTHFVTEIEKDSPEDKAIRRTVRLWTNFAKFGKPTVNKDDQILPVDWLPISKDKFQVYDIGEEVKLHDSHPETRAMQFWDEMHTINPFSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQQ2</accession>
    <name>A0ABM5IQQ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger BED domain-containing protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138994.2">
        <property type="nucleotide sequence ID" value="XM_028283193.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283193.2">
        <property type="protein sequence ID" value="XP_028138994.2"/>
        <property type="gene ID" value="LOC114333332"/>
    </dbReference>
    <dbReference type="GeneID" id="114333332"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138994.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16829" checksum="9D42DE048303F661" modified="2025-10-08" version="1">MFKVEDKISAMFLESAEQSLPDPIKINAAEHLRSLATTFRIYFPEPDPDDGWIRNPFSCQAIEQIQGLTEEEQDKLVDLSSCGTMKDIFNGEKIAEFWATARKDYKEFGDKAMKKILPFATTYQCEQTFSSNITEIMDAKVKFNVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISC6</accession>
    <name>A0ABM5ISC6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kielin/chordin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140493.2">
        <property type="nucleotide sequence ID" value="XM_028284692.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284692.2">
        <property type="protein sequence ID" value="XP_028140493.2"/>
        <property type="gene ID" value="LOC114334615"/>
    </dbReference>
    <dbReference type="GeneID" id="114334615"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045474104" description="Kielin/chordin-like protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140493.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31491" checksum="ED429907F1F353B9" modified="2025-10-08" version="1">MMIILTLKMSSIIKYTPLLCLIYLNFVFAVDTSENEIDDGHIYQKHAKSPASAIQDEVDILQLLNISSKDQGVSSVEGPIRNFPAYKFRLPYGNVLLSNATNVTLSMNNPKGFTAIFLIRQQKNNLGTLMSVNSPGRLSPWFQVISNSRVGVLTVKYRLKGMSKIKQIDWGLPKHHRKSPMAAWTWLSISFDPKDGIIRLDLDCDPSRFETIKQKKHLGNFSVPFDSLVYFGQEPGRKKKFLGSIQVAKVLPYILEQRLWSCVQIATNLSPEFRKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWU0</accession>
    <name>A0ABM5IWU0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145927.2">
        <property type="nucleotide sequence ID" value="XM_028290126.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290126.2">
        <property type="protein sequence ID" value="XP_028145927.2"/>
        <property type="gene ID" value="LOC114339465"/>
    </dbReference>
    <dbReference type="GeneID" id="114339465"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4817" evidence="1">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145927.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="198" mass="23288" checksum="7AA40A825217EDFD" modified="2025-10-08" version="1">MAHYSNSEMTDILLVLGECSGNAAAAVRRYREKYPNRNIPNARTFVSTERRLRETGCLQRRNTDAGRRREARNVRVEQQILDAVINDPRISTRRLGLRTNISHQSVLRVLHEQHLHPYHYRQVQELLPDDMPLRVDFCEVLQNKVQTAPNFLSNILFTDEATFTRQGMFNSRNMHFWAEENPRATMETHFQHTFKINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0F1</accession>
    <name>A0ABM5J0F1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155592.2">
        <property type="nucleotide sequence ID" value="XM_028299791.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299791.2">
        <property type="protein sequence ID" value="XP_028155592.2"/>
        <property type="gene ID" value="LOC114349418"/>
    </dbReference>
    <dbReference type="GeneID" id="114349418"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF2">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155592.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="156" mass="18104" checksum="6292838309BF64B1" modified="2025-10-08" version="1">MLNFFRKRSADKELEKPKMSNNNCRDISELKDIIYDLIRTIKDPEKPSTLEQLEVVYEDGVMVKHSKARNLNIVRIEFNPTIPHCSLATLIGLCIRIKVERSIPEPIKLDIYIKHSAHTTEQEINKQINDKERIAAAMENPNLKEMVENCIVEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHJ7</accession>
    <name>A0ABM5JHJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chondroitin sulfate proteoglycan 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497411.1">
        <property type="nucleotide sequence ID" value="XM_050641454.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641454.1">
        <property type="protein sequence ID" value="XP_050497411.1"/>
        <property type="gene ID" value="LOC126878629"/>
    </dbReference>
    <dbReference type="GeneID" id="126878629"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF12">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 4-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047004097" description="Chondroitin sulfate proteoglycan 4" evidence="8">
        <location>
            <begin position="21"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2177"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="9">
        <location>
            <begin position="207"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="438"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="903"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1466"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1809"/>
            <end position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2352" mass="265347" checksum="E019C624453462BB" modified="2025-10-08" version="1">MKNKALILCFLYFCFLKCRCVDQASFYGNSFIALPFKEARSSTDINFKFKTHLSSALIFLVAGNTDYCIVQLEKGRIKVNINLGSGEAEVVSPGNLKLNDLKWHEVSIERRDANLTLIIDKSHKVQKHLPGKFFELNIHYGLFIGDNKNRNNTDIFFGHLEKFRGCISELKYNGILVLDQARYRQSESIVQGITWNCAAEFDASVDQPISFIEDDSYVLISDKITNKKALNINFEVKTTKTNGLLFYNTGKKIKQDFLLIELSNESIISIIKINEKTTKLSSKNIKVSDGEWHKISVQMLPIVVELTIDETVFSEKNIHGSVFQMADTSFIGGLENSKRFRATQKGCSDSCDTSFKGCLRYLTISDVKKGIPDAQVTEGIMPGCLWHYPCLQNPCSNNGVCIQQGLDSFHCQCKEEFCVNLNYSEGYKVFSESSLATDLELLSVEPLQVLEGQSELLTTNNLHMILDYHKYGITDSGITFFVIGGPEHGSITLDIWPHDKNWFTFHDLVRDKVHYIHDGSEEKHDHLIMEVMFTTSDSFTLPEYLQGRFRFNFSVVVTPTNDPPVLDIADATVLRTVQGTKKFLSSDIFKVIDSDNTPDQLIYSILKCEDGYFENVNNPGTKISSFTQEEVNGGLILFYDKSSDKNTSYISMQVSDGLETSPVYRLRVAISPQYWRMERNTGLIVLHQSVSVITPYNLSFTSNVAIPDYLKYFSIVRKPAYGVVEVEKTGNSWEHSDYFTGNDLKQHRVRYRHTIANPDFDEFQFVTMDKTVIYTFRIIFARCSLQKSKLKTMLLMGEWEKQISTNDILFETKPTKPLTSIHYVIAEPPRYGYLFSAESKYKLKSCDVFTQEDIISHNVRYKLYQKPYSEVKDGFTFVAISSGCNNVTANLTIIYTPSKDNLTKLTVHLNNLEVDEGSPVAVDESHLSFQADFLSSVTFNITEKPKHGFLQKIDKDFRINGTNVFTTEDINSGSIYYVHDNSETRTDSFTFMALSSKGEIFQYVGQLNIKILLKNDNSPVRTVDKVFHVVVGGEKILTGKDLKYVDADLDTPQSQIIYTCRESSNGYFYNIANISTRVIEFSQDDLDNNRIIFKHKGPEFGKVRLWVTDGQFHLNGALEVQASAPFIHVNMKKKIIVEQGRIVAITSEHLSYATNLYAFDKDVIYEIINKPIFGKIVLSKTLKVVKNFTQDDINKGYVSYLNEHLGVNADEVGMKVTCKDAVNIAQLGIWILPSNYWEPLEIKTLNKISVEESTSVLITKKFLEVTQRNVPPSVITYYIVQMPEYGYITILSDVKNAEESVNILTFTQDLVNENKILYVQSTTNQTKDKIIFNITNGVVWNSNFQFNIEIIPERLFLGTSDLIVNEGGIGVLSSAQLFVLTDYYKSKVTSYSIKGNVEYGCIQVHKRCITSKSFSVKDIQAGAVQYLHDGTESTRDQLTVVGETDTKKTSVPITLNIIIFPVNDQKPKIVNNTGLTMWEGGFAYITNEMLAAVDDDKPKEILKYQVQTCWFGIVSLISNITAQLNTFTQDMIDEGLIVFRHYNGTGARFKFNVTDGLHTTKDCIFHIKTKPVEMKLINNPLPIFPLQKKFLTSKHLITVVSDPYRKIEYDVVKAPSLGRLMMESEKPGIFQVISTFSQEDLNTSKVFYEHTHQFSDLYANDSFVFNVRTHLAPKLLNQLFRIDISVSSGGLDAYMNIPKLYVDEGGTITIPLNMSGVVTFLESHAGLRSPIIHASALPPQHGQVYSQQNRNVTTFTQLQLESGQVYYEHDHSDTLGDNIYFSLYLIPGPITLCNVTVPIIVNPVNDQPFVLVTPAPSLVVVQGENRTITRHDLATEDADTPPEKLKYDVISGPSHGKLVLENISVTSFTQADIDNNKLYYVHNGSSLKDSFPFRIWDGKFRPQFNLFNVIVSPINISVKAGMVVNLLQGSYDIILSEQQFFINTNADKNKVEFSLKRPPKYGLLYKDNQANLTYFSYADLINGKIMYLQTDMSVSNDSFSVNGEIFSGGNSFGDCVEVVIRVKPFMHIHNLTTKAGETTRLTLNSLNASPLAKLTNGNPRYTIINHPKHGEVRKIIRSSGEKRNILDIAVSSFSHEDIQSGLIFFIVKETDVPKYSFLDRMVFILAANIVQPAVGELKIVVKSPLGNDIFSTLPGPSDPASHEGGLYLASPNMTKDYLLIVSMAVGIVILGIAVIVVIKCRSVDNHISKEEHCVQPIPLPRPPDRLMTSSPSLRESLPDEYAVEFTSEFPISFTTDVSADFAPVFTTDFTPEVSAEFTSDFSSDFTPLSIVPHCKVTPLAKIELESPHMFYPYGVDDQMDDWSEVLDEPEVPEPMPCPSNSSILLRKNQYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI58</accession>
    <name>A0ABM5JI58_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497623.1">
        <property type="nucleotide sequence ID" value="XM_050641666.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641666.1">
        <property type="protein sequence ID" value="XP_050497623.1"/>
        <property type="gene ID" value="LOC126878771"/>
    </dbReference>
    <dbReference type="GeneID" id="126878771"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="29"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="530" mass="57069" checksum="6490F83646F8F373" modified="2025-10-08" version="1">MTNETTKCEPQQEESEHEDSLPAPPDGGYGWVIVFASFICNMMVDGVTYCFGIFLPDLVTHYGSTEAKVAWVGSILAGTTMCTGPIVSAVTNKYGCRVSCMAGAVIAAASFALSVFSPSVEVLMLIYGAGGGIGFGLMYVPAVVCVGYYFESKRSLATGMAVCGSGFGTIVFAPFGRFLLVNYGWKGANIVLAVLCLTCTIFGFLMKPLEYKKPERTVTMVYQNGTANITDDMKKSYTSLGDLSASRHSLASKKSQALPPLARQDVLYAGSIRNLKEFQSQKSLHDFRQSMLSIPKHKSRYGGKALSGISKVFTELLDFSLMTDRVFIIIALSNVVGFMALYIPFDFLVEAAVKDGIDKSKASLLISFMGITNTVGRIVCGFVADFPKVNTLLVNNICMTVMTIAIGSAGFCHDYLSYSAMALINGCAMAGYISLTSILLVEFLGLEKLTSAFGLLILFRGAGALIGPPLHGIIINSSSYSYGFMAASGFFALSTILSFVIPIIQKNASKDKIIMHEDRMPVNRKIEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIN5</accession>
    <name>A0ABM5JIN5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTTM-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497802.1">
        <property type="nucleotide sequence ID" value="XM_050641845.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641845.1">
        <property type="protein sequence ID" value="XP_050497802.1"/>
        <property type="gene ID" value="LOC126878982"/>
    </dbReference>
    <dbReference type="GeneID" id="126878982"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053934">
        <property type="entry name" value="HTTM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053935">
        <property type="entry name" value="VKGC_lumenal_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12639">
        <property type="entry name" value="VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12639:SF6">
        <property type="entry name" value="VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22777">
        <property type="entry name" value="VKGC_lumenal_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM-like" evidence="8">
        <location>
            <begin position="38"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="656" mass="76566" checksum="2CA62B403F6DC1A9" modified="2025-10-08" version="1">MQVTLSTANYSLSLKLKFKQCWTRIKHLQYKDIVIYMYQPADPSSLGIIRFLFGLLMLIDLSEERGGSIIDLRWGHPNDCHFPLFPILKNPGYQCISLLYLLMWLGAAGIMLGYKFQISTILFGVPYWYLFLLDKSLWNNHSYLFGLISILLMGSSANQYFSLDGYLDKSLKNRDVPYWNYFILKYQFFLLYFLAGLKKMNMEWLDGYAMANLGEHWIFTPFSLVLYPEQIAYFIVHWFGFLLDLTIGFWMLIDVTRPVAFLFCASFHLMNSRLFSIGMFPYVCLATMPLFCEETWPKKIMSFFTNKNLDSLTSNNCVYQLKGKKDPPEYNTRITWQHKLVVGLVLSHCSLQLFLPYSHFITKGYNNWTNGLYGYSWDMMVHSWDTVIIIKVVDNENQREHFVDPQALTDGTRWGTHADMCVQYAQCLKRNIIPNIDSLDTNYKPKESLSSNISVYIDVWCSLNKRFTQRMYNPNYDLLKANWSPFQPVEWLLPLLTEYNNFREQMDKISEEVYSWSPTSDVMFVADFPGFTLENFIKDDVENATLTVLEGTIVYEIESTDTLQSEGITLHKDQSTPVEIDAFHKIHTISNTPSRLMYTFSKKDNNISETEAAFAPFPLIENMSEIIQSALIMWTHIKNSVLNIFFGTPYTLRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJP6</accession>
    <name>A0ABM5JJP6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498161.1">
        <property type="nucleotide sequence ID" value="XM_050642204.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642204.1">
        <property type="protein sequence ID" value="XP_050498161.1"/>
        <property type="gene ID" value="LOC126879172"/>
    </dbReference>
    <dbReference type="GeneID" id="126879172"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="641" mass="77580" checksum="72D4D0C9AC8A8469" modified="2025-10-08" version="1">MEVKQEISDEMCKVEVDYNDVDDAFWDGFKCEIKEEANTQITHDYLDVKEHLINTKIEPHENIHPFEEDQKTEKDYLQGNKKEIMETLTEHSPQENRVNPEADGKTLNKNILVAGKEPLKCEICFKQFTRARYFKRHLMMHKKPHKCEICFKQFTTEWNLKQHLMMHTGEKSHKCEICFKQFIQACHLKQHLRVHTAEKPYKCEICFKHFREQGHLKRHLMMHKKPHKCEICFKQFTTEWHLKQHLMMHTGEKSHKCEICFKQFIQAGHLKQHLRVHTAEKPYKCEICFKHFREQGHLKRHLMMHKNPHKCEICFKQFTTEWNLKQHLMMHTGEKSHKCEICFKQFIQAGHLKQHLRVHTAEKPYKCEICFKHFREQRHLKRHLMMHKKPHKCEICLKEFTTEWNLKQHLMMHTGEKSHKCEICFKQFIQAGHLKLHLRVHTAEKPYKCEICFKHFREQGHLKRHLMMHKKPHKCEICFKQFTTEWYLKHHLMMHTVEKSHKCEICFKEFTRAIHLKRHLMMHKKPHKCEICFKPFFTATCLKMHLRVHTGEKPHKCEICFKSFTTASKLKIHLRVHTGEKPYKCEICSKQFSTISHLKRHLKLHTGEKPHKCEICFKQFIEATRLKIHMRLHTGESTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPW5</accession>
    <name>A0ABM5JPW5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499978.1">
        <property type="nucleotide sequence ID" value="XM_050644021.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644021.1">
        <property type="protein sequence ID" value="XP_050499978.1"/>
        <property type="gene ID" value="LOC126880253"/>
    </dbReference>
    <dbReference type="GeneID" id="126880253"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="294" mass="33809" checksum="B87216531713E05E" modified="2025-10-08" version="1">MLVHRTQDNSLKTEWYRKPISSNRFINYYSEHPTRTKIKLILGLKSRVIKISHPTYREKSLKRLKNILMENSYPVGLLNKLIFSTATSPASITLIDNTNNKKPPTVNMASQERNTSPTIDTLVPTTPQTFGSLPYIPFLTPKLLKLFKGLENIKIATRNVKTIAHLYTKTKDPLTTKESSKVVYQIPCSDCDKVYIGETSRTLHSRIISHRSDINTKKSQACALADHSINLNHTFNFSQASILERVKNEQKRLFVEMTHIQKNRKCINRKSDIDKLSNIYCYILAYQQTFDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQK2</accession>
    <name>A0ABM5JQK2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500213.1">
        <property type="nucleotide sequence ID" value="XM_050644256.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644256.1">
        <property type="protein sequence ID" value="XP_050500213.1"/>
        <property type="gene ID" value="LOC126880412"/>
    </dbReference>
    <dbReference type="GeneID" id="126880412"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046767057" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="84"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="329" mass="36660" checksum="5F5A7231693436AD" modified="2025-10-08" version="1">MQNLSKMKAVHIIALFLPVVLSDDICSPEFVDLINNKNSTWVAHSNNYDENISIEDIKKLLGVKLRDQNLRNVKVFKHSENIQVPDSFDAREHWKQCSDVISAIVDQSGCGSCWAVSAASVMSDRRCIASNGKLKIPVSAEDLLSCCSYCGDCHGTSQPERAWDYWQETGISTGGLYGSKQGCRPYSLLNCTPSCPQFYETPACKHKCDNPKLDYTKELTFGQGSVHTFNSVEDIKKEILINGPVEATFMAYQDFLCYKRGVYQHVAGNDIPDGHAVRVLGWGEENGTPYWLVANSWNEGWGDKGLFKIILGKNEVGIESNMMAARPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR76</accession>
    <name>A0ABM5JR76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500443.1">
        <property type="nucleotide sequence ID" value="XM_050644486.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644486.1">
        <property type="protein sequence ID" value="XP_050500443.1"/>
        <property type="gene ID" value="LOC114337386"/>
    </dbReference>
    <dbReference type="GeneID" id="114337386"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="451" mass="50747" checksum="87E266B286901281" modified="2025-10-08" version="1">MDTNITDTTSTTAGTNTSSSTTTAIVAPATAPVMSTQVSTFQFSVEPFNQTATKWSRWVKRLEGAYKVFKIPEEMKLPYLLHYMGSEAYDTLCDKLAPEVPEDKSYEDTVKLMDNFYNPAPLEIAEIFRFQSKRQAEGESIQEYLHSLQKLAINCNFSTYLKSAIRNQFVFGLQSKRIQARLLETKGLDLDRAVEIAASMETSEKDSNQFSHNNNYNRASINVLNAKAKSSHKNTNTSKFNDNNTVNNHSSSPNNTSTMSNNPNRACYRCGDTSHLADKCNKKHLICNFCKNVGHIQKVCLKAQQNSHRQVNSVNSAQEVLEVNAGNCKDKFFINLKVNGNILNFEIDSGAAVTIINKNIFEKYFPALQLQKSDVKLTTYCKNNLNVLGLVSVEVEHQELKHTLKLYVVDGDGYSLVGREWIHALEINLHQNMETSCRPNTANWGIYSISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRX7</accession>
    <name>A0ABM5JRX7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500692.1">
        <property type="nucleotide sequence ID" value="XM_050644735.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644735.1">
        <property type="protein sequence ID" value="XP_050500692.1"/>
        <property type="gene ID" value="LOC126880694"/>
    </dbReference>
    <dbReference type="GeneID" id="126880694"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="84" mass="9483" checksum="65CFDFCB4016FC20" modified="2025-10-08" version="1">MGSATGGSGSEDEGATNTSGHSESDNCKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVGFNIFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSN6</accession>
    <name>A0ABM5JSN6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500951.1">
        <property type="nucleotide sequence ID" value="XM_050644994.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644994.1">
        <property type="protein sequence ID" value="XP_050500951.1"/>
        <property type="gene ID" value="LOC126880918"/>
    </dbReference>
    <dbReference type="GeneID" id="126880918"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="233"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="306" mass="35336" checksum="9AD4CBBA5BB5FF68" modified="2025-10-08" version="1">METLQLITQWKDSQSSSKAQRLLDTMLKTNFVVALHCLSHVLNITVSLSKSLQAKSLDKISARSFVNDILLVFHKKREDAENMFKGIFEEVTKVHQKLDFPILLPRINARQIYRSNIETKNPEEYFRVSVFIPLLENIFQDLEFRFNSDLFEILDINNLIPVNVLNQSDNNLKFLVKKVSEYLGKFRNDSVEFLSDLLESEIALRINKWKGIENKTNDLPATALDTLLLCSNEIFPTIYTLIQIISVMPVSVASAERSFSTLKRLKSWLPSTMCQERLVGLSLLNIHRDIEINIDAVIDRFSKQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSP4</accession>
    <name>A0ABM5JSP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500959.1">
        <property type="nucleotide sequence ID" value="XM_050645002.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645002.1">
        <property type="protein sequence ID" value="XP_050500959.1"/>
        <property type="gene ID" value="LOC114333295"/>
    </dbReference>
    <dbReference type="GeneID" id="114333295"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="409" mass="47574" checksum="DB53A8400860B734" modified="2025-10-08" version="1">MDTDHLHLEVAKTKWKSLRDNFRAELKKSIKGKSENDGESPIVSNWVWFQKLLFLKDQMLSRKMSLQRSTVTPGSAYVLTMNEGLQEDDTYDDSNSVYPIKTEIDIDNSEIEDQSSYTDQETPTISSSMYGTKRKRDEDGIESELLNLERKKIQLIQTQLAHSYDNQKLKPEDDLHHFLLSLYKPLSDLPNHLEVAKTKWKNLRDNFRAELKKSIKGKSENDGETPLVSNWVWFQKLLFLKDQMLSRKMSLQRSTVTSGSAYVLTMDEGLQEDDTYDDSNSVDPIKTEIDFGNSEIEDQSSYTDHETPTISNSMYGTKRKRDEDGIESELLNLERKKIQLIQTQLAHSYDNQKLKPEDDLHHFLLSLYKPLSDLPNHRQMYLRIKIQELIYNEMIDADQSREQINATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVR1</accession>
    <name>A0ABM5JVR1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050502030.1">
        <property type="nucleotide sequence ID" value="XM_050646073.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646073.1">
        <property type="protein sequence ID" value="XP_050502030.1"/>
        <property type="gene ID" value="LOC114340630"/>
    </dbReference>
    <dbReference type="GeneID" id="114340630"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF153">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045200071" description="Elongation of very long chain fatty acids protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="328" mass="38295" checksum="BA77E7AB17ABF3B4" modified="2025-10-08" version="1">MYCSSAVFSSKQLYLWLLSSITPQCRGADFCLTKMATIVNSTVIPKNSTNFYHFLFTEIADPRTNSWFLIKDPGPGLAILIIWMYFVLNIGPKMMKDREPFDLRKTLIVYNLVQVIISSYIFIRGGIIGWFGKYSYKCQPIDYSDAPEAQEMRHLMYLYFINKLLELLDTVFFVLRKKQNQVTFLHMYHHTVMPMVSWGGIKYVPGGHGTLIGFINCFVHIIMYSYYSLAAFGPKIQKYLWWKKYITAMQLGQFCIVFIHNSQLFFRDCGYPTWTAFITAPNAVFFYFLFSHFYNQAYGSRKQSKKSDKNAKKIETNNNVSQKEIKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWZ3</accession>
    <name>A0ABM5JWZ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502458.1">
        <property type="nucleotide sequence ID" value="XM_050646501.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646501.1">
        <property type="protein sequence ID" value="XP_050502458.1"/>
        <property type="gene ID" value="LOC114339303"/>
    </dbReference>
    <dbReference type="GeneID" id="114339303"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="246" mass="28449" checksum="D39613314DB3244A" modified="2025-10-08" version="1">MCSQSIVRGKDVDCNSNFYLSKVVLNIEEAEELYFATLSQSGSKWLDERRCRITGSICYQIYTYAFNSNPNWEQKVKSIFYSTFRGNANTRYGTEQEVNALKLYNEVHDCAAKKGGFIVNPQVPWVGFSPDALLDEDNKVTRLIEIKCPILGKSKSVLSIVRQLSYIKIINGQLQLNKKHQYYAQVQLGMGILGIKDCDLFIYCSYDKSFFTLPIKFDEEFVTKMLTILKEVYFEKIVKYLEIHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY24</accession>
    <name>A0ABM5JY24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050502842.1">
        <property type="nucleotide sequence ID" value="XM_050646885.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502843.1">
        <property type="nucleotide sequence ID" value="XM_050646886.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646885.1">
        <property type="protein sequence ID" value="XP_050502842.1"/>
        <property type="gene ID" value="LOC114334348"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646886.1">
        <property type="protein sequence ID" value="XP_050502843.1"/>
        <property type="gene ID" value="LOC114334348"/>
    </dbReference>
    <dbReference type="GeneID" id="114334348"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="873"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="934"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1238"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1296"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="10">
        <location>
            <begin position="51"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1476" mass="169571" checksum="2896DB1DFAF9B475" modified="2025-10-08" version="1">MRRRELYDDELEPLVENTQTQPKYQWDLFNNVPRETISGSTIESKYIDLSVKYLKIFTVIFTMLIVLGCAVVSKASLLFMTSQIKPNITRLYCNENLDTRQQYIVIHPQEERTVWIWIIIFSYMVPELGTFIRSVRIISFKSWNYPTKLDFLILATTEILPVIGSALLVFIVFPEIDVIKAAMLTNGVCLVPGIVAMISRSTSKVRQGLCYGLDIAAIVIQASALVVWPLVENRKILYIIPIALSLISVGWWENFLSEKTPIPWVKKFAKAKKQFKTDVYFTYALITPIKCLIFLLSAVTIIWIREGDVGFLFDKFGDAFSSHSFNVTQIEPVVGTSNINYTDAVADIHPTTMETSYWTPIVTWLINILSTYICYAFGKFACKIMIQSMSFALPVNLAVPVLLTALVSMCGMYNKNECAYTNVFPAYLFFNTPTMSRLEDFIGHQYSWIWFLWLLSQTWITIHIWSNDHEKLMSTEQLLKKPMYDAFLIDQSLAMNRRREHDRLIKIGREQTENENVPHDKITRIYACATMWHETKEEMVEFLKSVFRLDEDQCAHRIVRQYLQFQLPDYYELETHIFFDDAFIRQSQNDNDPHVNEYVLSLIDTVSDAASKVHAVNCKIKPPTVYSTPYGGRLEWTLPGKTKMIAHLKDKAKIRAKKRWSQVMYMYYLLGFRIMDNDKLHPTEIKNMAHNTYILALDGDIDFQPAAVHLLVDYMKKNSSLGAACGRIHPVGSGAMAWYQVFEYAVGHWLQKATEHVIGCVLCSPGCFSLFRAGALMDDNVMAKYTTESSEARHYVQYDQGEDRWLCTLLLQRGYRVEYSAASDAYTHCPEGFSEFYNQRRRWMPSTTANIMDLLTDYKHIVSINDNISKLYILYQVVIMIGTVIGPGTIFLMLVGAFVAAFKISQYESLIWNAIPVLIFIVVCATCKSDTQLFFAALITGVYGLVMMTVFVGMMIQIEQDGWLAPSSLFLVATMGEFLIAALMHPQEFYCLKYLIIYYVTIPSMYMLLVIYSIFNMNNVSWGTREVTVAPKPQEATQEATPNAAPAPAPRANQPLSFFGNSKDNAGSFEFSFGGLFKLLCCTYDSKGEEREVLRNIQTSIQNMQKKLDQMEKNKLGARDSILEPRKTARQTQLFVGLQAARVSQAAIPLQTQEFADEDGDADDDDDEDDSSNITPSEDVEPNSWYYDGSLIKSGVEFIDKKEKKFWEKLIEKYLSPLDETHKKDAVAKDLKDLRDRMVMTFFMLNALFVLIIYLLNLQQDIIHVNWPINPKVNFTYITDENMIIIEKTYLQLQPIGFVFLVMFSALLLVQFIGMGIHRFGTYCQIMANTHIDFSLFGSEVKNITEKSLLERDPIKIFKQLIRLQGINDEDDKEDTSVIRRETAHWLALKREKKAQPVIEDLEQAFYKRLSLFNSGKYKEQNNPFRDTMPQIAHIRNTILMRHSRLPEFTGGVSRNYERPDSAIFLDNPAENEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZC0</accession>
    <name>A0ABM5JZC0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503291.1">
        <property type="nucleotide sequence ID" value="XM_050647334.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647334.1">
        <property type="protein sequence ID" value="XP_050503291.1"/>
        <property type="gene ID" value="LOC126882400"/>
    </dbReference>
    <dbReference type="GeneID" id="126882400"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="121"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="224" mass="26249" checksum="2550F07681931CB0" modified="2025-10-08" version="1">MANVETTANKLGIELTCPRVAARQVHRPNHSTQTINEYYRKSIFLPYLDSLVQSLKDRFSDRNKPSFEIFNLHPKIMKDLSKEDFEKSINNINSTYCELLDNFKEQSILWFDLWKNTEIDAKALEKLNLIEVLEHEHACFLPSVAKAIQIALCLPPTTCTIERSFSTLKRVKTWIRNTMSNNRLSGLCLLSVHRRKIKENKENFMQKVIDLFAMDTRRIQLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZM5</accession>
    <name>A0ABM5JZM5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Circadian clock-controlled protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503389.1">
        <property type="nucleotide sequence ID" value="XM_050647432.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647432.1">
        <property type="protein sequence ID" value="XP_050503389.1"/>
        <property type="gene ID" value="LOC114345266"/>
    </dbReference>
    <dbReference type="GeneID" id="114345266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF41">
        <property type="entry name" value="RE70318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27027" checksum="F776F55DEDBA9A5D" modified="2025-10-08" version="1">MITCNANYIKACKPKETDISECIKQRVEELREQLNDGIPEMRIPSINPLEIPFAQMDLGEKSKASMKDIKLYGLPAFIIKDLKIDLDKDYIEIKVDIPHIRAEGEYTVKGKLLILTLDGSGPGQINIRDVLQSWNLLRHFTQNMISTSMNPIEYIHRVMEFQSKLSLLNKDIKSYEDLKQINSQFNSLHIEGQTWRSEEQQQQGLYAFRKLPQATYPLRRIQPTPWEPPTARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZY2</accession>
    <name>A0ABM5JZY2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503498.1">
        <property type="nucleotide sequence ID" value="XM_050647541.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647541.1">
        <property type="protein sequence ID" value="XP_050503498.1"/>
        <property type="gene ID" value="LOC126882569"/>
    </dbReference>
    <dbReference type="GeneID" id="126882569"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="163" mass="17528" checksum="AA09174E18740DBF" modified="2025-10-08" version="1">MEAISRTATVQRWRRPAGQQRSKLEAISGTATDSDGPRWRRSAGQQRSKGGGGQPDSNGPRWRRSAGQQRSKVEAVSGTATVQGGGDQRDSNGPRWKRSAGQQWSKVESISGTATVQGRGGQRDSNGPRWRRSAGQQRSKVETVSGTAMVQGGVDQRDSNGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0B5</accession>
    <name>A0ABM5K0B5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503630.1">
        <property type="nucleotide sequence ID" value="XM_050647673.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647673.1">
        <property type="protein sequence ID" value="XP_050503630.1"/>
        <property type="gene ID" value="LOC114330534"/>
    </dbReference>
    <dbReference type="GeneID" id="114330534"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19212" checksum="3FF780B5C20706FA" modified="2025-10-08" version="1">MFINSLITALSNYTERSPHKNKALRTPTNMMERQYMVRFRKTGPDELPSDLIKLVNQKSLDIISHEYPAPQGAQHGAPQAGIPQSTPSPFPTGGVGGVRRTLSGWREWRRADPTLINSLWRSKMGNGIRKQLGNAEVYIMLALLIGLATVVIGCWLSDNCWSPEPDSQIITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4R3</accession>
    <name>A0ABM5K4R3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505177.1">
        <property type="nucleotide sequence ID" value="XM_050649220.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649220.1">
        <property type="protein sequence ID" value="XP_050505177.1"/>
        <property type="gene ID" value="LOC126883575"/>
    </dbReference>
    <dbReference type="GeneID" id="126883575"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28670" checksum="116F5607A91053A0" modified="2025-10-08" version="1">MDKVEKKRERGKNYTEQEKENLLEIVKQYLNVIENKLTDGTSVKLKNEVWEVITEEFNATAQSGIRNAGQLRLLYDSIKKKARKDKANQKVEIYKTGGGLNKFQESDSIGEKYLSMASTSGTQPILNIYDSTAPFDELLRNEGGVAQVAEEVQDQGSLEQCTENEPLKLPEKCKRLNYVSGVPHHKKNKCEEGSEKEKIKLKILQIRQEKEELSRDILKLEKQKLELAVKEKILQLRHQYGDEFENLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K559</accession>
    <name>A0ABM5K559_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505322.1">
        <property type="nucleotide sequence ID" value="XM_050649365.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649365.1">
        <property type="protein sequence ID" value="XP_050505322.1"/>
        <property type="gene ID" value="LOC126883705"/>
    </dbReference>
    <dbReference type="GeneID" id="126883705"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27988" checksum="C49FC7FDF1748639" modified="2025-10-08" version="1">MENDRIPKVSKETLRKEIKDDLKFTYAKRSRKSVLIEREDLVSWRRRYLRSIREVRSAHKKIYYLDETWVNGGHTVSKIWQDTTVTSHRQVFVDGLSTGLRGPTGKGQGLIVAHIGSDSGFLDDSALVFVSKKTGDYHEDLDAQHFEKWFESLLARVHPNSVIVMDNAAYHSRLVEQLPTMATKKAHMQSWLGQKGIPFSQDMVKAELMSVIKQHRNKYRQHVVDTMARAKGITVLNLLLTIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9P8</accession>
    <name>A0ABM5K9P8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506916.1">
        <property type="nucleotide sequence ID" value="XM_050650959.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650959.1">
        <property type="protein sequence ID" value="XP_050506916.1"/>
        <property type="gene ID" value="LOC114325090"/>
    </dbReference>
    <dbReference type="GeneID" id="114325090"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF2">
        <property type="entry name" value="FMRFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="443" mass="50251" checksum="946D94F6D21045FE" modified="2025-10-08" version="1">MIDSTTGETPLPPNDSAPFIVWPIVNANPNDTDFQSCLLDSETIVFFQFVINGLLMNIIGVLGVLGNIISMIILSRPQMRSSINYLLIGLARVDTVLIITSMLLFGLPGLYPYSGMLFTYFYVVLPHIAPVVYPLATVVQTASVYLTVTVSLERFVAVCHPLRARSLCTYGRARIYVVGIIIFSAMYNLPKLWETTVQKEWSERDNTTIYCVRESELRGNETYIHIYIHWLYLICMYLVPFVALAVLNACIYRQVLRANKERQRLSRNQKREIGLATMLLGVVVVFFICNLLPLVINIIETFQVQIPFELDYLLQTSNLLVTINSSVNFIIYVIFGEKFKRLFLILFCNNNLFRSGRESPDGVTHEDSFISNGDRHSLRLQRHSTSLSRNGTGSNFGRTNGSTRIPTRNSCRYNRTSSPGPCVYYPANRNNKEITQTTVLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9T3</accession>
    <name>A0ABM5K9T3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Synaptotagmin-like protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506948.1">
        <property type="nucleotide sequence ID" value="XM_050650991.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650991.1">
        <property type="protein sequence ID" value="XP_050506948.1"/>
        <property type="gene ID" value="LOC126884772"/>
    </dbReference>
    <dbReference type="GeneID" id="126884772"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08521">
        <property type="entry name" value="C2A_SLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04020">
        <property type="entry name" value="C2B_SLP_1-2-3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15747">
        <property type="entry name" value="FYVE_Slp3_4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043567">
        <property type="entry name" value="SYTL1-5_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045864061" description="Synaptotagmin-like protein 5" evidence="5">
        <location>
            <begin position="18"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="domain" description="RabBD" evidence="7">
        <location>
            <begin position="78"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="2389"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="2535"/>
            <end position="2659"/>
        </location>
    </feature>
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            <begin position="1622"/>
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            <begin position="1645"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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    </evidence>
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            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2695" mass="297438" checksum="842E3EED9DE8DE98" modified="2025-10-08" version="1">MGKYQTVWFSGWRSVLFSFILDTFEKEMSCCDDSKAGAAPAAASASASGSASMPPVSAALGVPGECGDAPDPIVAAAMLEATQLTDSEREIILGVLGRDELLRREQQMRVLHLKAELQHIRRKGALKPSGAALDTTGPDQDPDRYCRRCRVELGRVINRGAYCRACRLKVCKACREYSFRTTDWVCTVCKKQMEIQAASGEWMNEFVRRPSKRRETRVCLPTADIIKRTIRRSWTISNPTPRWSAIRGSPELRPYNSLPRKQDINNYPSLALHQANLKNQEISNESTSPTYRRRSPRRTQSEDIYDDQGSSGQFRGGSPIGLRGNSPDMDVFVSRPSRMNPLMKLGDGRTEIDRRRSPMRKSNEGSSEDGSSKEDGSPKSRGILTPESIRKFDRNPIEKRVSFESHISNTRMLAKPAPVFRTQSLVEGRVQNHLMSRYPIHHEDNSDNSEDATTHSEANDGRDENNPIELCEIEPFSGTVFRKMMVRRRRNNLSASASNCATSSSENAPVDLCRKLPVVVLTFTVAGVTITILKPKTSNQSSDTVTGRTPGWRRGPDSDVWDILLPEGDDYKLVFINSDSSSKEETSSREEDDNDSSSTASSFPIDECDWDYFEPGSRPAPVINWSSPFGSPRVYRRDVAESPLGSPLVYRRRMRESDTGTDEDNVRQDSGSPASSDGIFQPRIHPDEPPFDAATQTRTEKVVEDSAALQCVHTEDIAAKPCCHACGAPTQYIPIPVPVPIPFPVPAMWPPHEPPLMLFGEQRFRVLPRNLWPYLSQAALIWPTLGANGGTAGTTMPATTDRDACALPTHEEPDNVSPSPALQAEEQISGYLECENRYDSSSDSSDSSDSSKPRVRRVYNVSGTDRHSDDALPSSNVSSDGEEEDGRMSQSSVREDDMTSSGSADTDSDDTGTVADQKSKRFSRIFVVNKVISSSSNSCSSSSDTDTSDNDTDTELDCTVILTNVKQLDEENDNQICDNKSSDKISEKIKEREYGSSSPGLSDVSAESVHSSDVDQTKDDNDTKDDISEKAEEIEEKIESPQVIPKNSKEEKDTETETNDINTQENALEVDSQKKDEGKKGKKKWNLIRVTMQFIKSEKKFSLVEKRVDDLSKESVSLKQLTMNDNRIEENGESLDKKGNPVVCDDNQEVSNNTKLVEPEVSSSKDLLNEEISLVTNEKLTKESAETVSNQLTNKPLETTSMAKFDNKHTSESDSKDKTSATRDSGKMIPYKKSSGSVKLSDVLLSGKAPSSPLGVISESVEAIPVVSAISCVDNEQPVDAVSSGETPAEAAGADDQQQRALGEWNEIRSGDAVNVEGNSVHDRNDGVHPGAIVCGEGLARHAARYTSLVMITQEPAPDYQQVSVVTSDTTTLVPGNDVVVRHTNWQEADHKRHQKICDNQNHEGESVTVITGGDTLSAFEEGLADDDSWVENLSHDEEDEDEFATNSGTDSSSGEEVTLTCSAAIDQEEDLRGYHRAAIDFTLHTIVEESCEESEVEQCISKRKERPTSATDLEKYFFFGLGDGLASSLPSNREDAFSETSSIYSEGMESLGGSEEVHTPNDTSDPAELASSRLEKYFLSGFMGFTAERRDSDGSVGSDSEGRPSPEQRRKRLVRARGTGRSHSSSLDNLDNAVSEQTVEAQLNSEDSSSSDSENYDENSFEKPDGQFDTVKRKKSKKPKSSNAEESKNLEITQEIEEKDSETDEDGHKTPQPEIPAAVTNLTTTKNQQSRDSGFVGSCDDLLREQRDNNTPDFTSGKNELKIELEDITEEKKSEDKAILLSTPPATSLTRKDSFNNWSSDEETNLMMCKMRQFFKTMVANSQLSSSSKPSTPTLSCTAKPLPSPRAKRCKPPQLVYFENELTRLMKTVPGIRDDQVREIVEYLSSEDTWSDSYDSSDYTSSDLEITTSKTVLQQQISDSCKQIINKFDNRVDDEGDEGDGGIIDESHGLNKETAFVYQKLVASIEKMASGDHSEATVPKVTPHSSPPLIAKVMHHIGSRLVALMHEVSSGESHASNSPKTKHYHRRLQHKISSASSTTTEDDCPEGSGDVMGYEDHHVPYNLLPRSRSHDLLMGETRAHQSTGGVSDIAEEKEASDCERFSWRGSFESALLATDSRNKLSLLGGEASASASALAIAAKRRSAGDLLFSHKSLSREQLDRVRSCGSIGGANSEDKLWVTSAIRPNRRRSSVPDATCGSGGSADGEDEDEEMESRSTLPRSLQGGTPTTNSLPRLPTTAAASSIQKSQSHHFLSQNVKSARYRPPGFNRLTAIPKRAVSAPGLQPSHQRRGRRSQQSNVINDEVGVSEAHSSPMLASPRNGTKSATPSPVTSVAKRNGARLNPDWHDEDLDRIGSLQNRGSLSTLGARSDSMASVYSGAGEGRYGTVAVRGQVEFGLQYNYKAGALEIQIKQCKDLAPVDTKRNRSDPYVKVYLLPDKSKSGKRKTKVKKHTLNPVFDECLKFHISLNGLESRTLWLTVWHSDMFGRNDFLGEVMMTLENKVFDDPTPKWYNLQERTEPFEDVSSYKGDIIVCLKFIPPDMTVQKKGKRSRGALHVLVKEAKSLTAVKANGTSDPFCKSYLLPDKGRSSKQKTPVAKRTTNPVWNYTFIYDDVTLQELAERCLELTVWDHDRLASNEFLGGVRFSLGTGKHYGKPVDWMDASGRELSLWKNMLEKPNFWVEGSLSLRSSLESRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9X8</accession>
    <name>A0ABM5K9X8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050506995.1">
        <property type="nucleotide sequence ID" value="XM_050651038.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651038.1">
        <property type="protein sequence ID" value="XP_050506995.1"/>
        <property type="gene ID" value="LOC126884799"/>
    </dbReference>
    <dbReference type="GeneID" id="126884799"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="157" mass="18103" checksum="6E4489F498A98F69" modified="2025-10-08" version="1">MPGRPSPLDNEQCRQCTSFSDYVKSAKKKTENGAVSDNVEKPRREDCPLDKDELGNKTWGLLHTMAAKYPDKPTVQDETSMKEFFTHFSRFYPCDHCAKDLRNDLKADPPQTKSQEALSQWLCKLHNKVNIKIGKEEFDCSKVNERWRDGWLDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA92</accession>
    <name>A0ABM5KA92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 22 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507109.1">
        <property type="nucleotide sequence ID" value="XM_050651152.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651152.1">
        <property type="protein sequence ID" value="XP_050507109.1"/>
        <property type="gene ID" value="LOC114326124"/>
    </dbReference>
    <dbReference type="GeneID" id="114326124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008530">
        <property type="entry name" value="CCDC22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048348">
        <property type="entry name" value="CCDC22_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048349">
        <property type="entry name" value="CCDC22_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668">
        <property type="entry name" value="JM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05667">
        <property type="entry name" value="CCDC22_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21674">
        <property type="entry name" value="CCDC22_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC22 coiled-coil" evidence="4">
        <location>
            <begin position="222"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="513"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="569" mass="65725" checksum="A319C7667132688E" modified="2025-10-08" version="1">MEEVDKIILDSLKNLDCDIDPEIEHLKQFDADLVAYAVASCLEAILQNGTLPKKLPPSMSARLKFASNLAEQIKDLGFRGDMGYQTILYCNEEEVRRMLMFLIERLPKETAKNIPIEQAGYVPRIVKSLEENIKLSLSKPWLPSCFLRQGARETSNRYLIHSMSSSCPLRTQKLDIPSSKTQNEDLKDYWIHLTPDVTKQCSPRKLIPSLLFQDNDISDDIDLKKVIKKSEAVSLDNLKSEVSSLSLISDKLTPTSTEKEIALSENDVNAETSEQYLIEKLSKEVESMKSEYVELQEDVKNAELKLVEIVRVTNEKQDHLKETLAKVKLKSKTATVLSKEENLAKLNNMIKNSNDRLVELAKQWEEIQRPLLEEYRSLKNNLTSEESKFQEQKEKLDGLKDVDVKLHEDLREKKMLSQNLLQQYQQLNRSNNRAMYTSRILEIIGNINKQNNDIWKVLKDTRQIQKEIKNLTGQVDRSFTLADELIFYDAKHDETARRSYKLLAALRDEFGSILKTLEDLGVVERECRNLEEQIESEKVKEIAIKLDRVYSDIKQIQKETQMLKEQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAR3</accession>
    <name>A0ABM5KAR3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507281.1">
        <property type="nucleotide sequence ID" value="XM_050651324.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651324.1">
        <property type="protein sequence ID" value="XP_050507281.1"/>
        <property type="gene ID" value="LOC126884956"/>
    </dbReference>
    <dbReference type="GeneID" id="126884956"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1520"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1956"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1956"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2032" mass="223176" checksum="C3CFDFD7ED33F2D5" modified="2025-10-08" version="1">MQDEATDTETDAVENKSSSEEKPAPVNLLSNLLDPLHLKDKAKDPKSESSSEEKPTPVNILGNLLDPLHLKDKAKDITDKVSDVVDNIAEPETKNTSEEKPAPLNLLGNLLDPLHLKDKAKEITDKVSDAAQNIADPETKSSTEEKTAPANLLGNLLDPLHLKDKAKDIADKVSDAAQNIADPETKSSSEAKPAPANLFGNLLDPLHLKDKAKEITDKVSYAVETIEDLESKSPSEEKPTPPNLLGNLLDPLHLKDKDKDITDKVSNRVETIADPENKSSSEEKTTHANILGNLLDPLHLKHKPKDISDEVSSAVETIVDPESKSSSEEKPTPSNLLGNLLDPLHLKDKAKDITDRVSDAVDTIADTESRSSMEEKPTPANFLGNLLDPLHLKDKAKDIPNKVSDTVETLAKPEFKSSSEQKTAPANLLDNLLDPLHLKDKTKGISAVASDAVKNIPDPKQKTSSKENLDPLNLRDNLLDPLHLKDIAKEIADKVSETIENTANNKASISPKGKPDPVKLLDNILDPLHLKEKTKEITDNVSNIIGNITDSKPSEDKPPPLNILGNILDPLNLKGKPKDVLDKSNQPDLLGNLLDPLKLKDKVKDLTEKVSDTVENIANSMPKNASDENYIPNNLLGNLLDPLHLKGKNSVDNKKVDVLGNLLDPLNLKDKANDIAGRVSDVVENITDPLNLKEKSSNSVKDKQNLFENLLDPLHLKDKEQELPRDPLANILDPLNLKDTAKDLTEVVCSVVENIPDPLNLKDKINNSTKDKPNLLGNILDPLNLKNKAKELNDKLSINDTRNTGDLLGNILDPLKLKDKLEDLSSTVSDVIEKIPDPLNLKEVTAAPTKDKLNLFGNILDPLQLQDKTNDSAEKPQHILGNLLDPLHLKDKAKDLHEKVAGAVENITDPLNLKDKSTDSTEKPQHILGNLLDPLHLKDKAQDLHEKVASAVDNIIDPLNLKDKPNSSEEKPGLNLLDNMLDPLHLKDKAKDLTEKIAGAAENFADPLKLKDKEKTSNPGDILGNILDPLHLKDKAKEIIDNKGGNNAGLGNILDPLNLKDKAKDLIDNTSDHGKVLGNILDPLNLKDKAKDLLDNKSDPGKVLGNILDPLNLKDKTKDLLENKSDPGLVLGNILDPLNLKNKAKDLMENKQDPAKVLGTIIDPLNLKGKISDAVNNTHNIINILPDPLNLKDKAKDLIENKNDPGKVLGNILDPLNLKDKAKDLIENKNDPEKVLGNILDPLNLKGKISGAVENTHNIIDTLPDPLNLKGKSKALADTLGNVVDHTTDFIDSFPDPLRIKERPKRLAGIIDNMPNIIPDPLHLKDKSQDILNTISDPKKIKEKGRNIINIAVPGASHNKTEAVTKPEEPKPLFPANDPFNFKKNAEEAQKAFKEKGLGGWIATVQKNVQKLLAIVLNLQIVILITPVVQAAYPLLLTTINIIKTTWITIFKVLTGTYLPTLPIPTDISLENTKAMVSTVSSFKNEIKNPKDLADKLKIEVPPKPKNLKKSIQQLNVQNLVSRFGILGIILFITALIKKILKRIRKFIKITIKSLERVFHLANEQYIKNLDRHLTRIQSASMEKVEMLVSGKSYVPDGMQNIDTLRQKEISTFVDKQTMVSTVASFKNEIKTAKNVADKSKLEVPLKPKDLKQSIKQLNVQNLIARFGLSGIILSVTALIKKILKQIRKFIKVTLKYLTKVFDLAIQSYYFKKLDDYCLTRIKSTSMEMLVTGKSYVPDEMSNIDTLSQNTASAIVDKQALSRTLLAKIPATDDLTKARMLLKNNLSGHKEMPDTSTWPHNLADNKVKISNSVVSQMPATEYLEKVKLLKSTITEESSVSSVVSAVISEQNISLNDIVASKMPATEYLEKVKLLKSTTTEVSSVVSAVISEQTISVNNSIVKLPNSNHILEDYIPNSKKLMSSKISPQNAMFKLPSPHKLVGEVIPDSSKIGDSKLSLTNSPLNLPSTDQISDGSPSTSKTASSTLFISERVSISKTSVSHGILSTKSTISDKNLTLEKTTPEYSIVTAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCS0</accession>
    <name>A0ABM5KCS0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507986.1">
        <property type="nucleotide sequence ID" value="XM_050652029.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652029.1">
        <property type="protein sequence ID" value="XP_050507986.1"/>
        <property type="gene ID" value="LOC126885458"/>
    </dbReference>
    <dbReference type="GeneID" id="126885458"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="472" mass="52293" checksum="BE5CD22383C07AF0" modified="2025-10-08" version="1">MIENSLTFQQHLKQQNTLRSISSKIKLNNAQERTNNSNIVSFVAGTVLTWTSPVLDRLGNATTTPFDHPVSLDERSWISSFFPLGAIFGPFIFGFLADQIGRKKTLIISGIPFVVCYYLLAFSRHVVVYYIARFFLGIALGGVYTVIPMYAGEIADNSNRGTLGSMMNVYLCFGLFFSYCLGPFVNLMTFNIILGTFPIIFLVIFTLIAPESPVYLLSKNDIRGAKIALQKVRGYNEDINQELDMIQNKIEEDGKGSVIDIFKSKPLTKALGITVTLGVIQQFSGVIAVFFYAQTIFEQAGSSLKPEICSIVIGSVQFLTSFLTPFLVDRWGRKLLLLISAAGMALSEILLGIYCLLHDHHYDVASITFLPIICLMAYIFMYNFGYGPLPWVIMGETFPPNVKSSASSITAAICWIAGFIIGKYFEPLVVIIGIGPAFLIFSGICILAVPFCLFLVVETKGKSVQEILRDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD48</accession>
    <name>A0ABM5KD48_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508100.1">
        <property type="nucleotide sequence ID" value="XM_050652143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652143.1">
        <property type="protein sequence ID" value="XP_050508100.1"/>
        <property type="gene ID" value="LOC126885557"/>
    </dbReference>
    <dbReference type="GeneID" id="126885557"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="60932" checksum="60967C275990B1B3" modified="2025-10-08" version="1">MSDQNRTKRMATKGALTRLTTYFRSIENNEIIDLVDLEMRLSKAEELLDVFNEVQLLIETDDPDCEENYDTIHAIERRPTETSDSRSVNGSVAAGPTNTSNIKLPPLNLATFDGSFDEFLFFRDSFNSIINDNTSLPNVQKFHYLRLSLRGIAADTIKSLQVCDANYGIAWSLLTERFENKQLLVNNHIKALFNLPLVTKESNQGLRQLLDNTQKHLRALEVLKRPTKHWDDLVIYLLTTKFDNSTRRSWESQNCKDNLPVLDDLLKFLKERCRILESLYNYNDNKQDQNSPRYKGNKSETRAFVSNTENRFKCNFCNKKHKIYYCPDFLKLNPTNRLNNAKRLRLCLNCLGTCHRTKDCRSTGCRKCGKIHTMLHFENSQSSNSVSTENNSSQSSLSSNVPNTGLQSNEFTSTSNFFSTHHISSSVHTAIKPYILLLTAVVNVFDKFGNSHKCRVLLDNGSQSNFISEKFYSANYCTSAYYRRLPNEVTQVQSPGLLGDEKVHNDENTHKTNASMNEHFYSLHSSYCNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFT4</accession>
    <name>A0ABM5KFT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509061.1">
        <property type="nucleotide sequence ID" value="XM_050653104.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653104.1">
        <property type="protein sequence ID" value="XP_050509061.1"/>
        <property type="gene ID" value="LOC126886239"/>
    </dbReference>
    <dbReference type="GeneID" id="126886239"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="131"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="351" mass="40020" checksum="7767892614BB076E" modified="2025-10-08" version="1">MFGLHLNVFKTKVLVFSRTRINVHLYAKGQILEQVTSIKYLGANVNGQSISPEERLAITLRYLATGDTFYTIGHSFRVGFSTVSAIVVEVCEALCRNLQHIYLPEPTTEIWKKSEEGFRNTWRFPNCIGSIDGKHVTIKCPDKTGSNYWCYLNKFSTVLMAIVGPDYRFISVDIGGFGKNSDGGIFEASNMGRRFETNQMGVPEPKNLPGQNELSPHVLIGDEAFALKPYLLRPFPYSQSRTDIFKENYNVRLCKARRVVENAFGILAQKWRIFYRPMETKIDTSILIVKTACILHNFLRTKKCDDRFIELLDPPEPELGAFQNLDNDPRRAARLAFSVREKFATYFNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFT7</accession>
    <name>A0ABM5KFT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509059.1">
        <property type="nucleotide sequence ID" value="XM_050653102.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653102.1">
        <property type="protein sequence ID" value="XP_050509059.1"/>
        <property type="gene ID" value="LOC126886237"/>
    </dbReference>
    <dbReference type="GeneID" id="126886237"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1291" mass="150239" checksum="C74A8A629B907319" modified="2025-10-08" version="1">MSLIADLIVKIASILGLIPNNYNDEKIREGLMKCNKAIKNIRDSMRYAKTMGEKQHLEAQMRQVKTLRNQLKVEQKKGAGLTPTKETAKHRVQWDDSLSAFNSRIRTGVISNLKHKDPGSFLVDCKALFKRRIQNALKKEAAVKVNIAFGGEFEIAQGDKMINETKYFTTSNSAIYRDTNLDEWFEKKVVEPISRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIELPPQIKRKKACVNVKNDDEACFAWAIVSALYPATKDAQRVFKYPHYSDVLKLKGIQFPMTIKQIPNFEKQNNISINAYNLKKEKKNYTTLPILLTKNRKDKHINLLLIQDNYDEPPTQYHYVWIKNLSRLLSKQLSTEDGTKYFCDACLHYFRSQEQLNAHKTCCKGRSDVICDRCLQPFSSSKQLEAHTTDCVRINETAIKLPDESRKMLRFKNYRNKIKAPFAVYADLESALKRTGDPKKYQEHIPVAVGYFFKCSYDDTLSFYNSYRGKDCMKWFADELNQLAENVSTVFMCPYDINMTSQQERDFHAATHCHICEQRFSPSDKKVRDHDHMIPEHNYRGAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVNDIATHIKGPVDLLPITKEKYISFTKHIDHARIKFRFIDSFRFMASSLDKLSSYLTEYPNLNSQFLSLSEENFNLLTKKGIMPYDYIDSFQKFNETCLPPQEAFYNKLEDKPCPRRHYRRAQDVWSSFSCSNLGDYIDLYMKTDILLLADVFEQFRSSCLKTYNLDPAHYFTLPGFTWDAMLKHTKQELELLTDPDMFLFVERGIRGGLSQVCSKRRVHANNKYMESYDPSKPDSYLMYFDVNNQYGWAMSQFLPYGGFEWVDANIDVLSTPDDASEGYFLEVDLEYPQHIHDRHKDLPFCPQSLNPKTMLPPKRPREQTKLMATLHDKERYVIHYRTLKQALAHGLVLKKIHRVLKFKQSPWLKSYIVLNTNLRKAAKNEFEKNLFKLMNNAVFGKTMENVRKRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLVAVEMHRAEIWLDKPIYVGMSILDLAKTTIYDFHYGYLDRRFGENFTTCYTDTDCEIVEIREKDPYEAVKTDCHKYFDTSDYPKDNMYGIPQVNKKVLGLMKDENNGCIMTDYIGLRSKLYTTKVAITDNDIMKLRGKLIDQEYEDDEIEILIKNYGVTKKAKGVKKSVVKTKITFEDYVECLDTFTTKTASQNLIRSDKHHVYTITQSKIALSPTDDKRYHLPESYDTLPWGHYLVDNLKMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG45</accession>
    <name>A0ABM5KG45_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050509169.1">
        <property type="nucleotide sequence ID" value="XM_050653212.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653212.1">
        <property type="protein sequence ID" value="XP_050509169.1"/>
        <property type="gene ID" value="LOC126886339"/>
    </dbReference>
    <dbReference type="GeneID" id="126886339"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="459"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1121" mass="132287" checksum="00266CE79F5C00D6" modified="2025-10-08" version="1">MTQFIAHLSCTKVNSTFCAEFILKKEDEEVTSRKYFHTVTEVIDASTDLKEWFTDYIVEPLLNKLENFQEKDSGYSLSNIISLEINVNKYEVGKGPSSFISLPKQILDRKACINVKNNDNACFYWSIVSALYQPINKFNLNRTSSYPNYTTVLNTNSLELPMPLWQIPKFEKMNNISVNVFGLEMNKNGSFETVVLRVTKHKKPRHVNLLLIQDKYFPKDESMIDESEEEEEYNDEDDNNEQYKINYHYCWIKDLSRLLYKEISKKKVKKYICDRCLNYFYSQEDLNDHLTMCENINDCKVMFSTNKIIKFKNFVNKEIVPFVLYADFESILKPLKQLEKIENRHRYQQHEPFSAGYYLKCFHDNSFTYYNSFRGLECITWFANELDKIATVISARLKHVEPLNVNINLEDAINCHICERDFTPTDTIVRDHSHLTGHFRGFSHNACNLNYKNWFVIPVFIHNLMGYDAHMLIRDLSKLYYIKVLPLNKEKYISFTVYHKKTHIQFRFLDSFRFMGFSLEKMVSFLDKEQLENLKAEFKNVSSDNFELLTHKGIFCYDYIENIERLNETQLPNKIQFYSKLNDEEISEEDYAHAQKVWENFNIKDLGEYSDLYLKTDVLLLADCFENFRKMCNRTYNLDPAHYFTLPGYTWDCMLKYTKCQLETLQDVDMLLFIESSIRGGVSQCSNRFSEANNKYMNTYDPSQDSKYILYFDVNNLYGWAQSQYLPYGNFQWIDDHEKLDVTTIPSDSPIGYLLEVDLSYPVELHDLHKDLPFCPEKLAPQNTKLKKLLTTLHNKEKYIIHYENLKQALKHGLVLTKIYRVLSFRQSNWLAPYIQLNANLRAEAKNDFESENFKLMVNANYGKGMENKRKRRALHLVRRYEGRYGAKNLIASPLFHSRVIFDDNLMAIELRQSSIIFDKPIYTGMAVLELSKTCLYDFHYDFMLKQNSVQQCKLLYTDTDSLLYEITCYDAYEQIIKANISKFDTSSYKPDNVYDIPLVNKKIPGLMKDETSGKIILAFVGLRSKQYTYKIFNDNKEISFKKAKGIKRNVVDNKITFDDYLYCLENSVSKTASHRYIRSILHTVFSIEETKIALSPFDNKRHLLENSFDTIPWGHYSIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGY3</accession>
    <name>A0ABM5KGY3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509466.1">
        <property type="nucleotide sequence ID" value="XM_050653509.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653509.1">
        <property type="protein sequence ID" value="XP_050509466.1"/>
        <property type="gene ID" value="LOC126886554"/>
    </dbReference>
    <dbReference type="GeneID" id="126886554"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="322" mass="37359" checksum="47B13543120F746D" modified="2025-10-08" version="1">MEIKQEASEETCKIKVEETCVGPLESLGAFKIEIKEEPKTETAYQAFDYVDLNEFPVKAEAEQDEYKCTPFEDEQTTNEESFAQKKLLEMEIMSTLPEHSCNKEQQLSPNSGETVQTEKRLYKCEMCSKQFSQSCNLKQHTKVHTGEKPYQCEICFKQFSQAGSLKRHLIVHTGEKPYKCEICFKPFSETRSLKKHLRSHTGEKSHECEICLKEFTESGSLKRHLKVHTGAKPYKCDICFKEFTESGSLKTHLRTHTGEKPHKCVICLKQFTDKSTLKTHMRTHTGEKPHKCEICSKQFSVTSSLKKHLRMHTRVKREKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KH14</accession>
    <name>A0ABM5KH14_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509484.1">
        <property type="nucleotide sequence ID" value="XM_050653527.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653527.1">
        <property type="protein sequence ID" value="XP_050509484.1"/>
        <property type="gene ID" value="LOC126886576"/>
    </dbReference>
    <dbReference type="GeneID" id="126886576"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
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            <begin position="133"/>
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    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="161"/>
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    <feature type="domain" description="C2H2-type" evidence="9">
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        <location>
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    <feature type="domain" description="C2H2-type" evidence="9">
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="385"/>
            <end position="412"/>
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
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            <begin position="441"/>
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        <location>
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        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="553"/>
            <end position="580"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="622" mass="72720" checksum="F737499BAF7D35F1" modified="2025-10-08" version="1">MEAQQEIDEDTCKIEIVDNHLDDALLEGFKCEIQEESNTEEQHGNKTNPFKENQETEKDCPQENNMEIMETLDEHSFLEENDVNAHAERKTLNKSVKVVTAKKLHKCEICFKQFSQEGNLKRHLRVHTGEKPHKCEICFKQFSQEGNLKNHLRVHTGEKPHKCEICLKQFTKANNLKVHRRVHTGEKPFKCEICIKQFISIQNLKEHLRLHTGEKNHKCEICFKQFSRKPDLNGHMKIHTGEKPHKCKICFKKFITASHLKSHLNVHTGAKAHKCEICFKKFNHGSNLKRHLRVHTGEKPHKCEICYKKFSEASSLKPHLRVHTGQKPHKCEICFKQFREAGNLKAHLRVHTGGKPHKCEICDKQFSKASRLKLHLRIHTGEKPHKCEICFKQFREAGTLKLHLRVHTGEKPYKCEICFKQFRQASDLKGHLRVHTGEKPHKCEICFKQFSKTGDLKRHLRVHTGETSYKCEICFKEFSEAYTLKKHLRVHTGEKPHKCQICFKQFSEAGSLKLHLRVHTGEKPHKCEICFKQFSQAGNLKTHLRVHTGKSTYKCEICFKQFSKTSTLKNHLKIHAKEKVYECEICLEEFTERRNLKTHLKVHSKASFKHNDKSQQLVVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KH46</accession>
    <name>A0ABM5KH46_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509506.1">
        <property type="nucleotide sequence ID" value="XM_050653549.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509507.1">
        <property type="nucleotide sequence ID" value="XM_050653550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509508.1">
        <property type="nucleotide sequence ID" value="XM_050653551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509509.1">
        <property type="nucleotide sequence ID" value="XM_050653552.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509510.1">
        <property type="nucleotide sequence ID" value="XM_050653553.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653549.1">
        <property type="protein sequence ID" value="XP_050509506.1"/>
        <property type="gene ID" value="LOC114328055"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653550.1">
        <property type="protein sequence ID" value="XP_050509507.1"/>
        <property type="gene ID" value="LOC114328055"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653551.1">
        <property type="protein sequence ID" value="XP_050509508.1"/>
        <property type="gene ID" value="LOC114328055"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653552.1">
        <property type="protein sequence ID" value="XP_050509509.1"/>
        <property type="gene ID" value="LOC114328055"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653553.1">
        <property type="protein sequence ID" value="XP_050509510.1"/>
        <property type="gene ID" value="LOC114328055"/>
    </dbReference>
    <dbReference type="GeneID" id="114328055"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15203">
        <property type="entry name" value="7tmA_NPYR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF30">
        <property type="entry name" value="NEUROPEPTIDE F RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="121"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="236"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="61"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="400" mass="44998" checksum="305F6223021DCA6D" modified="2025-10-08" version="1">MDNNSVMPDDNSTSSTDAYNDSDYVDPRLMERYLQNKAIDEPAYTVLIVMYCFLMIMGALGNTLVIVAVVRKPAMRTPRNMFIVNLAVADLLLCAITMPLTLMEILTKYFPLGNNLFVCKIIGILQATSTYVSTISITAIALDRYQVIVYPTKESLQQFGATLILLLIWVVALLLAMPLFVVRHLVHHTVPMESECLNINFCIENWPVEHGRAYYSIFSLIFQYTLPIIIVSAAYVRISYKLRNRFASGFTSDEGHGNRRELRGRRLHRTNLLLGSIAVIFCISWLPLNVFNLVADLSANASFTSQPMMICYAVCHMMGMSSACSNPILYGCLNENFWKEFKDILCIESSIDTPGHSKKVSFRKSSQKSQNKSKPDLVTGAMDYQPCNTVSTDMTVLTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KII6</accession>
    <name>A0ABM5KII6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510015.1">
        <property type="nucleotide sequence ID" value="XM_050654058.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654058.1">
        <property type="protein sequence ID" value="XP_050510015.1"/>
        <property type="gene ID" value="LOC126886907"/>
    </dbReference>
    <dbReference type="GeneID" id="126886907"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="247" mass="28092" checksum="DB28B02AEADD9B74" modified="2025-10-08" version="1">MAFTKIYIFPILFGIWIPLTVFITFTVSVLTEHVRPLLPYISDTGTWAPESCIFGIMLTFGSIFLLIIVYVRYRYLQEVQRKNNYSPTLRKINKAGLYVGYVSIFGCLIVANFQVSETFIVHNLGAFSCFGCGAIYQVIQVKLSFKMYPTIGHRKNNIFRAVVTAISCLTFITTFICAALSIRYFTGTDMTKWKQEDGGYEFHIASAVSEYVLVISTVLHIVTYFYEFRTIEFNEPPISIKGVVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLB3</accession>
    <name>A0ABM5KLB3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510990.1">
        <property type="nucleotide sequence ID" value="XM_050655033.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655033.1">
        <property type="protein sequence ID" value="XP_050510990.1"/>
        <property type="gene ID" value="LOC126887477"/>
    </dbReference>
    <dbReference type="GeneID" id="126887477"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36302" checksum="BFEC00469FFB3366" modified="2025-10-08" version="1">MRETLINSLTKIPISIKPAFKKVSSDNFIKNVLTSDLRVSIEVCPNRALNEDLLSSIPFSFCSVTWRTPSNEQLEHVDQIPALILAKQLNSNGYNVLLHLAGRYLKREQVVRILEEVKSAGIRNLFALQGDPSEIKEKDDKKCDFPYASDLVTFIRERHGNYFCVGVAGYPEKHPQCENIEKDLQYLKFKVTRGADFIITQASYDYQRFLTFSQQCHLMGINVPIIPGVFIISSHRTLTAMSKFCGVTIPRNIIDAVEAVKGNDDDVAKFGVQHATELIGKIFENQHLFAGVHMFSLNNLELVKSVLQKTNINSECLVPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMI2</accession>
    <name>A0ABM5KMI2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket protein 28-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511394.1">
        <property type="nucleotide sequence ID" value="XM_050655437.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655437.1">
        <property type="protein sequence ID" value="XP_050511394.1"/>
        <property type="gene ID" value="LOC114327712"/>
    </dbReference>
    <dbReference type="GeneID" id="114327712"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="63232" checksum="64E901BCFE5775B4" modified="2025-10-08" version="1">MERKMNLGKLDFDIDEEERRQKEQKHYTWVENCKYYILEYCREGSLHGLKYLGQKRTFAEKIWWAISMIISLYICTKLVLNAYQKWQNTPVIVSFATKDTPNWMIPFPAVTICPEIKAVPSKYNYTHFLGLKMKGETLSPIDEERFGYLSLACRRNTKHIDFAQVRLNSGQKEDIYSFLDWVQPDFFSTISHCQYMGYEENCTDLFTPIITDEGICYSFNILDRSQIFKPTVEHYKDFHRAKPSNWSIENGYSLDDTAITYPRRALYAGAIFSLEGVLTVKDEDLDYSCGSSIQGFKVEISHPGRLPRVRQQHFRIPLDQVVVAAINPSITTTANAIKRYPPKKRNCYFPNEKQLRYFVNYTQMDCQIECKTNHTLKRCGCVDFYMPREHDVQVCAEERINCIFESERELLLSNIEKKLHSLKQGKIAKDKCDCMPICTSMYYNLETSQATWDWQDQFDTNDEQKHMSSFQIYFKSNQFVTMERNELFGITDFLANFGGLLGLFVGFSLLSLIEIVYFLTLRIICNVALFGRYNWAGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMV2</accession>
    <name>A0ABM5KMV2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-nucleotidase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511531.1">
        <property type="nucleotide sequence ID" value="XM_050655574.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655574.1">
        <property type="protein sequence ID" value="XP_050511531.1"/>
        <property type="gene ID" value="LOC126887769"/>
    </dbReference>
    <dbReference type="GeneID" id="126887769"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF38">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="51046" checksum="3967FBB692B618A9" modified="2025-10-08" version="1">MYTKNVLKLVRPVINRTFSYTATQRKLNSDRAFNINHYDCIGFDLDNTLARYRIGNMLELEYRILSNHLVKERNYPGDLLLQPVDPNFFIKGLIVDDEHGNVIRIGPDGTILQATHGTKWLTPDEILQYYPTRHWKATDLFVQDPLQTWNGPYSEKMRTLLDYFDIAISLIFARAVDAIDAVHGQKKVYNIWPDLLNALMHMFNREHFEQDAGGYFPELKYNPDLYYYKCSPNVLNWLKELRDRGKKLYLITGAHADFANHTASSTLGPNWRDYFDIVVSYAKKPGFFMHERDFLVLNDSYKETGPALELRNGSIYTHGNWKMLKEHLTRLSSAQTPKFLYIGDNLVQDIYTPNVHSGCDTVNVCEELEVEKLDLYTGESHPDRHILSSSLWGSYFEIKDSNQKTVWYNIMKNHSKICVPSVDYLARFPIDHDFKCAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ48</accession>
    <name>A0ABM5KQ48_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Multiple epidermal growth factor-like domains protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512312.1">
        <property type="nucleotide sequence ID" value="XM_050656355.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656355.1">
        <property type="protein sequence ID" value="XP_050512312.1"/>
        <property type="gene ID" value="LOC114327794"/>
    </dbReference>
    <dbReference type="GeneID" id="114327794"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11 13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="2588"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1151"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="17">
        <location>
            <begin position="1274"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1326"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1478"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1296"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1308"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2722" mass="303555" checksum="89F9DC0CEDEA46E1" modified="2025-10-08" version="1">MRPQIINYSLTEIVICFIVVGYAAVDLVPCDKTRRIFQTSWGIISDGPAGSNYTQDSHCEWLIKANDSNKFITLKFQSMGTECSYDYVFVYDGDSFNSPLLGSFSGKTEPQEVIATSGYMLILLYSDTNYVLEGFKAEFSITDCPNNCSNHGVCYDHRCACETDWGGYDCSRKLCPDNCGRHLMHGHCDQGQCVCRAGYSGESCNLYEFDSVGNKWHWLSHSEGGLQPRAAHSAVYIEITDALYVFGGYNLNTVLGNLEIYNFQASAWRDEYGAIIPDTGLISSIEPSLIAKLIEHAGPDWEQKWGINSGTSFLRNLLYAGTENTTHIRRRQRHSRVPDEQKPAPRYGHSACAISKGFVLYGGKLHNGSLANDLWYYNVQTRQWQLRATLSNVVPPRLTRHTLTCANNNIYLFGGSTENGEFSSSLYIIQLLPDLDEFWEEIKPRGGKQLDVRVVAHTTTYHPHSNSLIVYGGIVPGVARFSKLSDRMFVFQLDNLHWTEIHYTREHLREKFVPRERAFHTANIFGNYLVVFGGYSHRHNKEEICYDNQMYLYHLGCHTWVNPDILGKTNDSRYPKQQGVFAHASAVRNENTLLLVGGYHGNVNGDLLAYTVPPMVATRKGEPYFPEAACARHKNYGECSADPECGWCSADEQCYGRTIGANCTTNLQTTKCPGICPALGDCHSCLIHGHPLPQNSPMASAAHKLGLEQCTWCVQNARCHHKDDNYGVCGLQEDSPSQIPGWWGAKGTEVVRPEQCRELDKRPGLTFVKYHYPVNYSQPDNVAIINATTVDFISPTSSLPRGDFSSGGEMVARLLGFLRLPTSWQEMLNVCVSFCSATLNLSDHLVANVTPEVKECKAVKWPDNLTLERIPVDFMAKKIVNVQAAYSVYMQQSKMELLHYKDSDDAPKVFTFEYLEPYANGTCEQYKNCLHCLTDSQCGWCELTNSCQSRSIEENVSCSVDGNWQYLTLQPSACSNCSNYISCDSCIQSNLCEWWIEDARCQRIGQRVDAAITLEQCPVPCHQRTDCGSCLDQKGRCVWCQATQQCFSFSVYTSEYQFGLCREWMDQAFPLVARQENGILPVPKTQEQCKTCSMHTNCSTCLSALSCGWCYNSSNPMTGVCVQGDFNNPHVNCSIALKAADAKWAYAQCPDVDECGLGLHDCHEQAICTNTDGSFSCHCRKGYIGDGRKNCHRTCFNVCVHGICQGEPDYSCKCDIGWYGDDCSKNCGCNNHSACPQGEGICEECVDNTMGEFCEECRPGSYGNATSEQGCRKCDCNGHGNKDKGECDMDTGVCFCEDNTRGDHCERCKNKYFGDPKNGKQCYYQCDRGILRDSHGQGISSRQAYIPPWGGTPTRECLWIIKPDTNIGTPIIQLQINSSQLNISCGENAVYVFDGLPELVDMGSQSPLSAVFCTEEALALGTVESRTGQLTVHYKQGEPGESFSAFYKVISCDDCRPPRECRNGQCVCQDGYVGFDCEQSICLDNCNHDKGQGSCDKSYGRCLCSAGWTGPSCGIKKTKTQLTFTELFNTVKLSESLEHFRKTLPRFGHSLVSDRRGALWMFGGLSLSHGPLNDVRLFDTKNLTWMQVTIESTPDAKMPMGRYFHGADIGHTQTIYVYGGLSKKHKNYRNRTLDDFWQFDIQNQRWGEIEKTDVWPPALSGHTLTYHKSQESLILIGGISPQNGFLNLVWAYKFGKEQWVPINTKGPGPLGIFGHTTVYHAQSSNLFVFGGVVYERQLSTISNNLYMFNYENRTWTQLNNLGSTLHWPRPRYFHSAITTEDYMIIMGGKIYPWNITDTLYAYSYNCNRWMNLMSNDIEKIGPFPTQSYAQGMTVEPDGDAIYAIGGWGIETQSTVLRIELPTDLCNLLPRRITCLYMSGCGYCASKVGEDIIAEQCHSNTKECTLETPENASLVTNESQVCSLYNIYQTSPSNCSTIQDCTICIQSGSCSWCQGVCTSNANNCNSTLASCPYNKCTATDCIQCHQMPGCDWSYSRRQCMSVTQEQEANSVAVCPQPCINYSTCSSCLETPDCRWSTQLDECVSESYQDVYCAGGVCGLVLRPDERQHCPEPCNSFTQCSSCLKHAPCGWCATPGLSGEGFCAEGSNVRPMLGTCEEVFLENHRKVGEVEAIEPLNNVTYSWHYVKCPPEDECNNGHHTCAIESEICVDLDEGFECNCGEGYKDGVNGCEPVCPLGCVRGQCIQPKKCLCDFGYVGANCSIQCQCNGHASCEGPDKLDKCLVCHNNTMGAQCEKCKPLFVGDPADGGVCVSCSDYCHGHSLICVDNSTEIDTGDYIDYEFLNKTLKEGPKANAKCLRCGNLTSGARCDDCIRGNFRGTEDHRDPCRPCDCHGHGDTCDPIHGDKCNCQNNTESDVCRGVSDKNSAHPCWMVQCSKCKEGYLGTPTSGHQCYKQMHVDNKMCFDAKPMDECKMKPNALHPGEVVFFVIQPRFMNVDIRIIIDVTQGRLNVFMSTHDDTYVASRNNTSGFIDVDIDSMYGHWENGTLRSKDVYLEREASGYKTYITITQPKTILLVKKLQDRLVITLPEEYHSLETTRFFLVLQALEPTDSEKKVAYGIVFSRQDQLHIDLFVFFSVFFSCFFLFLAACVVAWKAKQAADVRRARRRHVVEMLHMAKRPFASVTLNLSARTKPKKSAHHDLRPVAVEPTGDGVAAVATVFVSLPGGQSASVKLALASSLILLARQFPTGGRIFLRRRSIHAAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQI9</accession>
    <name>A0ABM5KQI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBSPON-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512455.1">
        <property type="nucleotide sequence ID" value="XM_050656498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512456.1">
        <property type="nucleotide sequence ID" value="XM_050656499.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656498.1">
        <property type="protein sequence ID" value="XP_050512455.1"/>
        <property type="gene ID" value="LOC114328453"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656499.1">
        <property type="protein sequence ID" value="XP_050512456.1"/>
        <property type="gene ID" value="LOC114328453"/>
    </dbReference>
    <dbReference type="GeneID" id="114328453"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056801">
        <property type="entry name" value="SBSPON_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25031">
        <property type="entry name" value="SBSPON_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBSPON-like C-terminal" evidence="1">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="157" mass="17781" checksum="BC0C0D949E8D66E3" modified="2025-10-08" version="1">MLSQCNPKEESMMIVPPIGTQIAMLLPGSLSHSRSVNNTSDIRKNLRVRDPAENPQYDPEKTYCVEFEVLKASKACRKEDTYKVLREGDKVCIRCESEALHEDLNWRCQGHGVEGHITRWSALSAPHCHGKWLRVRTEPDRNCSVRTCAAGPAFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQJ6</accession>
    <name>A0ABM5KQJ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512463.1">
        <property type="nucleotide sequence ID" value="XM_050656506.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656506.1">
        <property type="protein sequence ID" value="XP_050512463.1"/>
        <property type="gene ID" value="LOC114328437"/>
    </dbReference>
    <dbReference type="GeneID" id="114328437"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="305" mass="35330" checksum="F09B21085C8D74EE" modified="2025-10-08" version="1">MNKVIKFPFFSVNIQLYRKKVLFYARMLCCALYLSLTVICVETTVIWTIADNEAELYEKFNPYLNKISLYRKSSFEVYLPFDTSLDGHAWLNRIPEVLRIVLLQTFIAIDTALTGSLIHLISQTMIVNEAFKYVDKDIDTNQTLKNIFLVKEIRLVKCVNELQKIYRGFEILEEMCSWQILIQCGLATLLLCCLTYIIPLVTSKTEGFCCVVFLCASLGNIFILSYCCQTLTLELQNVALSVYETDWPFYPLRMKKIVLFLLRRLQKPACLTAGKMFSINLTLFNLIIQRSYSFYTLINASTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQX8</accession>
    <name>A0ABM5KQX8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050512596.1">
        <property type="nucleotide sequence ID" value="XM_050656639.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656639.1">
        <property type="protein sequence ID" value="XP_050512596.1"/>
        <property type="gene ID" value="LOC114325268"/>
    </dbReference>
    <dbReference type="GeneID" id="114325268"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF9">
        <property type="entry name" value="ENDOPOLYGALACTURONASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046374661" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="367" mass="40236" checksum="264D3313BD08AB8D" modified="2025-10-08" version="1">MYFSRNYLYIFLNLTAVFVPSLTEAQEQCTIREFSQISEVIERCKNITVSNLEVPANVTLDFDLQTGSTLTFEGVTLFKNATWVGPLVRFRGSQIVVQGAKGSFLDGQGALYWDGMGGNGGVTKPYFFQIETTGGSIFRNIHLLNCPHHCVIISSTDLTITGWNIDVSAGDKGNLGHNTDGFDVIYGENIVIENSIVQNQDDCVAINRGKNMLISNLRCYGGHGISLSVGFSHRSYKHNTVHNVTFIDCVVARSENGIHVKTHNDGYLGEIKNVTYKNIEFVDILNYGVNVQQDYANGTSTGNPTNNIPITNLSLINVHGTVKGSHATGVYILCGSAGCIDWNWSEISITGAKRENSCNYVPSGYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRR5</accession>
    <name>A0ABM5KRR5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512880.1">
        <property type="nucleotide sequence ID" value="XM_050656923.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656923.1">
        <property type="protein sequence ID" value="XP_050512880.1"/>
        <property type="gene ID" value="LOC126888574"/>
    </dbReference>
    <dbReference type="GeneID" id="126888574"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="302" mass="36280" checksum="09E95E48D021AE4A" modified="2025-10-08" version="1">METCDDETFSGTPPEIVKAAEDAKLSLQPAKSKKIYDKVYDEFVSWCKLQNVKDEVDIPKEDKEEELTPETVDYKDDVEYLRSLDPKEWKSQDHYKVLGIPNIRYKATDDIIKTAYRKKVLKQHPDKRKALGEEIKTDDDYFTCITMVYETLGNISRRRAYDSVDPQFDNDLPCTSDIKKDFYGVYKTFTYYFDLNSRWSEKTRVPKLGTENSTKEKVEHFYSFWYDFKSWREYSYEDEEDKDKCQDRDERRYVDKLNKAERLRKKKEEIKLICGEEKEKELRVILRECENLINEENRRENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVA9</accession>
    <name>A0ABM5KVA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynamin-1-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514126.1">
        <property type="nucleotide sequence ID" value="XM_050658169.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658169.1">
        <property type="protein sequence ID" value="XP_050514126.1"/>
        <property type="gene ID" value="LOC114338660"/>
    </dbReference>
    <dbReference type="GeneID" id="114338660"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="22"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="652"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="744" mass="83936" checksum="61EED501E031B805" modified="2025-10-08" version="1">MEALIPVINKLQDVFNTVGTDAIHLPQIIVLGSQSSGKSSVIESLVGKSFLPRGTGIVTRRPLVLQLVYCPKEDREHRSAIDGTVELDDWGVFLHAKDKIFRDFDKIRLEIEDETSRMAGNNKGICPEPINLKIYSTKVVNLTLVDLPGITKVPVGDQPPDIEQQIRELVLKYIANPNSIILAVVTANTDMATSESLAIAKDVDIDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVVNRSQQDIMNNKSIKDSLKDEATYLQSKYPTLAGRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNLMMSQYQSLLSSYGEDISDKSKTLLQIITKFASAYCSTIEGTARNIETTELCGGARICYIFHETFGRTLDSIHPLAGLTKMDILTAIRNANGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIIQHCGNEVQQEMLRFPKLYEEIVDVVTQLLRRRLPTTNSMVENLVAIELAYINTKHPDFYKDIQVVPTVIKSAGESGNRPSRPKSMFGKHQAESLEMRPVAEPEERGDFINDLLRILPLTSYNEFMSVIKARSSSNPHLNNDDDKPWAVNANANGKENDYNHVNNIPIQHTVESELKNILSPEKPVNLLPQVPVNSSSFRKLSEHEEHDCEIIERLIKSYFYIVRKSIQDTVPKAVMHFLVNYVKDNLQSELVTHLYKADNAEPLLDESEHIAQRRQEASDMLKALQRASHIISEIRETHMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXX9</accession>
    <name>A0ABM5KXX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515032.1">
        <property type="nucleotide sequence ID" value="XM_050659075.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659075.1">
        <property type="protein sequence ID" value="XP_050515032.1"/>
        <property type="gene ID" value="LOC126890221"/>
    </dbReference>
    <dbReference type="GeneID" id="126890221"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="97"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="356" mass="41415" checksum="DE17BC5643D7B82D" modified="2025-10-08" version="1">MKNKEDLRMKEIIEQEIIKQFDEDRELLRNESRYNSQTITIPVPNVTYMTLPYISDIAPKFTRLFKPFENIKLSFRTALTVNKIFSNIKDKTPMLSKTDTVYRLSCLDCNQIYIGQTSRRLKDRITSHKSDCRLYPGRSALGEHVFNNGHQIDYNDVQILDQNKIDESTLSESKNNVETPFNKYDKEKKQDHLNPKANILLEPDVKLNDNIDNDSQPLNKTLDLYKFQENDLEEKASKSPEYDKLEEKTYIPLKAVNFDCYPILTKIDTNPNTNHRDYEDNEYFSESRDTSSYVPETEIESEGGEEETIYPIFKTINVTCPESTLTKDEPSEKPHISNIETNNSIVALSHRKKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY24</accession>
    <name>A0ABM5KY24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515085.1">
        <property type="nucleotide sequence ID" value="XM_050659128.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659128.1">
        <property type="protein sequence ID" value="XP_050515085.1"/>
        <property type="gene ID" value="LOC126890271"/>
    </dbReference>
    <dbReference type="GeneID" id="126890271"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="2">
        <location>
            <begin position="187"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="274" mass="29995" checksum="B6C3E6BFFD51E877" modified="2025-10-08" version="1">MCTNSDPCKPGKPSGYQFKLKRAAKEEKETDLLRKIPKISSFFSIDKSKTITEVSTDDDRDAILLPLSSTSSSVSISDGNQSGKGETDDDLDAILLPLPSTSSGVSISDGNQCGKGETVKSVENSEITSFDCTGGVVFSSDPSLWKVNDELRDHVAVHGVLQNCDADFSTSKRQYSHKVRYASESMFVRKILNGETQNRSWLVYFKVKGCVYCAPCMLFGKYADSESAFVNGFNDWKNASQRLKDHENSSGHKTSLGNLKVRGNTKARADSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY82</accession>
    <name>A0ABM5KY82_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515153.1">
        <property type="nucleotide sequence ID" value="XM_050659196.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659196.1">
        <property type="protein sequence ID" value="XP_050515153.1"/>
        <property type="gene ID" value="LOC126890330"/>
    </dbReference>
    <dbReference type="GeneID" id="126890330"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37167" checksum="A638B5CE8C6B399D" modified="2025-10-08" version="1">MWRPWENSALEIVENNEVEIVEENEEILPPNNPENAAGPSRGSIKKPERKHLSKDAKEIVLNVFNGLCEELERHESVLKTAALTKVSCATVYRIIKEGITNRQKRSDFGLHQSIEQHLLGPISETIYNMFAGNIIPTLNQILAELKSKNIINCCKSTLRKFLLSNGFKYKTINKRHTIMESARLIKWRNEYLEKITEYRNSGRKIYYLDETWFDTNETIGKGWSNDNVKCKVNVPPSRGKRICVLHCGGEDGWVTDSLLLSAKDIKDSCLDYHQDITGELFESWFKNNLLPLADNSVIVLDNASYHSRQLKKIPNKYSRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0K2</accession>
    <name>A0ABM5L0K2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515968.1">
        <property type="nucleotide sequence ID" value="XM_050660011.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660011.1">
        <property type="protein sequence ID" value="XP_050515968.1"/>
        <property type="gene ID" value="LOC126890819"/>
    </dbReference>
    <dbReference type="GeneID" id="126890819"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="302" mass="33045" checksum="2EC13037591BC6CB" modified="2025-10-08" version="1">MDLQCLNTIDCNQGAVRAVRFNVDGSYCLTCGSDKKLKLWNPYRGLILKTYGGHGNEVLDACGSCDSSQIVSCSSDKSNILWDVSTGQPIRRLRGHAATVTCVKFNEESTIVVSGSLDNTVMFWDVKSRSQDPVQVLRDAKDCVTSIQVTDHEILAGSVDCSFRRYDLRNGRLDADFVGAPVVSVSFTHDGQCILAGSADNTVRLFDKNSGEMLGKYTGHRTDDVNIESAVITNDNFILSGSVTGELWCWDLVSAEVVKKFVHTRGRVLNSISIHPRKDVVLTASVGSIKVWGEPEVTITED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0R4</accession>
    <name>A0ABM5L0R4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516026.1">
        <property type="nucleotide sequence ID" value="XM_050660069.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660069.1">
        <property type="protein sequence ID" value="XP_050516026.1"/>
        <property type="gene ID" value="LOC114336990"/>
    </dbReference>
    <dbReference type="GeneID" id="114336990"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1225"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1281"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1365"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1449"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1478"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1501" mass="172849" checksum="12D292D870420818" modified="2025-10-08" version="1">MSDQIEVKQEFSEVCKKEEDDDEVGDALLDTFKIEIKEEPKRESASDTFDSADLKEYPIKTEEEQDGVSCEDIPNYVRNISKYTGSNLNRNLTATTDVNIAENHFECEICLRQLTTIYSLRDHMRIHTGEKPFICEICTKQFSTNKYLTAHMRVHTGEKPFGCEICTKQFSTKQVLKSHMTVHTGEKPLTCKLCPKQFSTNIQLTRHMRLHTGEKPLACEIYNKKISEYGNPKLHMPIHSGVKSFSCEICAKKFVQAASLRIHMRVHTGEKPFTCKICAKKFSDAQSLKYHIKSHTGEKLFTCEICSNRFRKSSDLQRHVRVHTGEKPFICQICNKKFSQRSSLNHHMKTHTGETSFTCYIPRISVLEHSNEVLIIMPNKRNKGIRGKWREENMQNAILAFGNGQSVNSAKAFAPSSVTEDKNVEGPGLQDILQHNEKQPVRVITPPPGPSNVSRKLPVTELRDNSDSEDDDESEANEDENNEYEDDEYEPTKEVSFNEMLETPEMVHKYGTRKKKTVLNSRAQVVTKDLFNRSTDFVPEKTLTPKVSEKNSKTRKVEIRRNEHKSKDESVSCEDMQNDASNLLNYTGNNLNKNLTATTDVKTEENLFRCEFCSKQLTRSSTLKRHLRVHTGEKPFRSNSVHIGSSTLQLHVRVHTGEKPFECEICSKQFSIKQDLKRHMNVHTGEKPFECKICAKHFSRKSVLKSHLTVHTGEKPFTCNVCRKQFSHSSTLRAHMTVHTDEKPFVCEICAKRFSLKKQLKSHMKVHTETSAGYRLLDPVTHKIEIARDVVFLEEKMNDKPFEERSMSFPLEQTDIEVAMVPKLPEVETDEPANPETVTVQENNQVSIRPSTSKSVNENDCGENEANDCLELSTPLCRVGYSTLEYKHNTETDKIMSDQIEVKQEFSEVCKKEEDDGEVGDALLDTFKIEIKEEPKRESASDTFDSADLKEYPIKTEEEQDGVSCEDIKNDECNPILKYPGKNLNQNLTATKDMNIVENHFECEICFKKLSTRFSLKEHMRVHTGEKPFTCKICTKQFSLNNYLTKHMKLHTGEKPFECEICTKQFSTKQVLKGHMRVHTGEKLFECEICTKQFSTIQVLKWHMRVHTGEKPFECEICTKQFSMKANLRVHLKLHTGEKPFECAICTKRLSSKEVLKRHMVVHTGEKTFECAICTKQFSSKEVLKQHVVVHTGEKPFTCKICTKQFSLKNYLTKHMKLHTGEKPFECEICTKQFSTKQGLKGHMRVHTGEKPFECEICTKQFSTIQVLKWHMRVHTGEKPFECEICTKQFSMKANLRVHLKLHTGEKPFECEICTKQFSMKANLTVHLKLHTGEKPFECAICTKQFSSKEVLKRHMVVHTGEKPFECAICTKQFSSKEVLKRHMVVHTGEKPFECAICTKQFSSKEVLKRHEVVHTGEKSFTCKICTKQFLLKNYLTKHMKLHTAEKPFKCEICTKQVSTKQVLKRHNMVVHTGEKTFSCKVCSKQFSYRPSLTAHMKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L111</accession>
    <name>A0ABM5L111_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516128.1">
        <property type="nucleotide sequence ID" value="XM_050660171.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660171.1">
        <property type="protein sequence ID" value="XP_050516128.1"/>
        <property type="gene ID" value="LOC126890990"/>
    </dbReference>
    <dbReference type="GeneID" id="126890990"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="121" mass="14015" checksum="5608357E073AF97C" modified="2025-10-08" version="1">MRPTDLGANLSFESIQNKSCDFSVCPIQINDDAVNLLSRVLWKKVVFRASRLQFNKLISSRWSQICVQMNEVNRKLDLILAQSSLQPPNQQEDSFTIPDFLTNLPVKDDMWRFPGVQFPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L115</accession>
    <name>A0ABM5L115_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516132.1">
        <property type="nucleotide sequence ID" value="XM_050660175.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660175.1">
        <property type="protein sequence ID" value="XP_050516132.1"/>
        <property type="gene ID" value="LOC126890995"/>
    </dbReference>
    <dbReference type="GeneID" id="126890995"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="459"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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        <location>
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    </feature>
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        <location>
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            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="857"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="909" mass="106810" checksum="E3965123FF182D9F" modified="2025-10-08" version="1">MEPDKIKVEQIEVKQEVSEETFKEEIDNVYEMGDDLFDTFKIEIKEELKREIITNDDAFECSLLNENAMKTEIKQDEEKHTNEKSFPHEDVQTDTNKVFKGHGMANSNLDEYLTVRKTFTCEICCKMFSQKGNLKEHIRIHTGDKPYACEICSDRFTQKSNLNTHMRIHTKEIHTGKSFTCKICTKEFPHNSFLRVHMRIHTVHKPFACEVCSKLFSRRSNLKEHMRVHTGVKQFECEVCSKLFSRRSGVIQHNMRIHTRDSFQCKICSESFSQLLSLKEHMRIHTGDTPFTCEICCKMFPRKWNLKEHMKIHTEDKPFECEICSKTFSKRGSLKEHMRTHTGDKPFTCEICSKSYTQKIKLTEHMRIHTGHKPFACEICSKLFTIRSSLNDHMKIHTEDKPFTCNICSKSFLRGYYLTKHMRIHSGYKPFACEICSKTFSQKHNLNEHMTIHTGDKPFSCEICSKSFSHISSLKRHMKIHTGFPHGDVQTDTNKVFKEHGIANSNLEEYVTAHKPFTCEICCKKFSQKGNLKGHILSVHTRDKHYACEICSDRFSRKSYLKSHMRVHTKEIHTGKSFTCKICTKEFPHKSFLRVHMRIHTVHKPFACEICSKLFSRRSNLKEHMRVHTGVKQFECEVCSKLFSRKSGLIQHMRLHTRDPFQCEICSESFSQLLSLKKHMKIHTRDTHFTCEICCKRFSQKWNLKEHMKIHTEDKPFECEICSKTFSTRCSLKEHMRLHTGDKPFTCEICSKSYTRKLKLTEHMRIHTGDKPFTCEICSKSYTRKLKLTEHMRIHTGDKPFACEICSKLFTIGSSLINHMKIHTEDKRFECEICSKTFSTRRSLKEHMRIHSGYKPFECEICSKLFSQRGSLKEHMRIHTGDKPFSCEICSKSFSYISSFKRHLKIHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L116</accession>
    <name>A0ABM5L116_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516126.1">
        <property type="nucleotide sequence ID" value="XM_050660169.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660169.1">
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        <property type="gene ID" value="LOC126890987"/>
    </dbReference>
    <dbReference type="GeneID" id="126890987"/>
    <dbReference type="Proteomes" id="UP001652700">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1"/>
            <end position="10"/>
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            <begin position="21"/>
            <end position="48"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="55"/>
            <end position="65"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="70"/>
            <end position="83"/>
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            <begin position="198"/>
            <end position="212"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516126.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="220" mass="24988" checksum="397E79476510CCED" modified="2025-10-08" version="1">MTRVRSRSPPRSKALSPPRYADSKESLLLQHPEESSDDHSSDQEDGKDGFTIQNRRTRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTRANEEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKPEKKNPEKTDKKPPAAITTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1G1</accession>
    <name>A0ABM5L1G1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomeloidea</taxon>
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            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516276.1">
        <property type="nucleotide sequence ID" value="XM_050660319.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050660319.1">
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        <property type="gene ID" value="LOC126891138"/>
    </dbReference>
    <dbReference type="GeneID" id="126891138"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="89"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="225" mass="25775" checksum="415CDDCDF0FA0D06" modified="2025-10-08" version="1">MAADSSMYVRGRYGKGLLFHKLLETLEEENEMPEYILIFPPEEPPDFSDEEVAGDTNHLPARILRSQVPEPDNEYRPNVEDLLKETVKSPIDVFRCYFTQDIIEHIVRETNSYAGQKLVHNLNATSAEILTFVGVMLLSGYHPLPCRRLYWTVDEDVHTPIVSNAMRRNRFDELMSFIHLADNQSNDGTDRMYKIRALLDMLNSAFKQITPGPSVSVDESTIEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4W9</accession>
    <name>A0ABM5L4W9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517480.1">
        <property type="nucleotide sequence ID" value="XM_050661523.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661523.1">
        <property type="protein sequence ID" value="XP_050517480.1"/>
        <property type="gene ID" value="LOC126892087"/>
    </dbReference>
    <dbReference type="GeneID" id="126892087"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="358" mass="40569" checksum="3844AA67178739D4" modified="2025-10-08" version="1">MEKYFRADKLEADPNSQTAAKEFKHWYETFKNFLESNKSTEKSLEDKDKYMLLINFVSHSVYDYISEAKTYISAIKILEELYIKPTNEIYARHILATRKQQINESIDQYAQQLKLLAKNCNFKAVSSEENKNDYIRDAFINGLVQSNIRQRLLEFSSLSLDEALSKSRSLEDSQKQSDTYHAALNNIASCSHPNSEQTTLASVQTKPGQTCYFCGHPRHPRSVCPARAAICQNCDKIGHWFKMCMQSKKSQTRSTYASTMVIASSMETPQSLSKCIAKVTVNQIDANALIDTGSSDTFLDHEFAIENKLKIFPIQGVQVSMASMSFSANIQGYCLINIQILSNSEVCRLANLLSDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4Y3</accession>
    <name>A0ABM5L4Y3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pleckstrin homology domain-containing family G member 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517497.1">
        <property type="nucleotide sequence ID" value="XM_050661540.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661540.1">
        <property type="protein sequence ID" value="XP_050517497.1"/>
        <property type="gene ID" value="LOC126892103"/>
    </dbReference>
    <dbReference type="GeneID" id="126892103"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13243">
        <property type="entry name" value="PH_PLEKHG1_G2_G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043324">
        <property type="entry name" value="PH_PLEKHG1_G2_G3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="322"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="529"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126788" checksum="1BB3C558CE96A1CE" modified="2025-10-08" version="1">MCTKNGYADSKGSSPELMPTIMGAFDAIIGSSNRENEADLDLKTSTPRRSHQLSNFANLSPYVQKVLSNVPEQEISKKFSSEETLGSRRFHSSRNYRSFRSPDKYMNKSNENLEIISTNVQKMLSNLPDTELVISASNLNLTRNSSYLFNSSSRSEFLKQVLDSGESPSDEHKPNGVKQFLYHSDGVSGTKDSDNGVVDSEKCCESEENCDSYNQKPLGSYLHSSHGIASRTPVGRKNMGKYLQVPSESSVGTSSTASSEVSRPVSLTSLGSCSSSGSSGHHQAGSAYLASAESLDSDPEPTGSQGSADSGIAEQEQPTISPESRVLQEVLETETVYVEDLHEVITGYLEPWKSDPECPLAQHLSHLFSNLETIYKFNRKFLEDLKEAEGEATKTANCFLHHDSGFSVYNEYCQNYPTTMEVLGQLTRDEKMAALFREKQIALGHALPLGSYLLKPVQRILKYHLLLQRLSKQCDPLHKPAVDLALTTMTGIASDINNMKRKHEHAVRVQEIQAQLYGWNGPDLTALGELIAEGTFRVVGARGRRHVFLFEKVLLLAKNKQGGALAYKSHIMTNNLMLVEQVRGEPLSFQVIPFDNPRLQSTLKARSPQHKREWTLQIKRVILENYSAVIPNHARQLVLQLGQDLHETEDVNNDKWSPLKQNSTPHYLERRSRVRKTRDFSNRRAASQDRTFPTLANWRRKSEPSMVPQYNPKKAVKVKKHKESQSATFYTDLSDSENCADESLENIQQNLSENTAEELKEEERTDCVNNNLEQIVSDILMQNQNFHKAFNRQTGRKAVTNDPSSVWCEEKVKLPTKADSLPRSFQLYDQPDSTNGVECKNERLVLDMSLKENPDFDVEEQQENDLSSQLDDTEHPDHKIYRKSTIRFSILQRIRHIMSEEQKRIQKYPIRKQGSKSMGEKIAHPDYVDPQKLFLGSASCSQIDLSQDKNEESDILGEPEQLDLSINEKDVLNEWEKRLNGGTTVSDTGQDHNSSHSFISSQSSDSYYEKILDDSLKEEYIKDSTGKLVAKQDSFSSNEDRSSLNQKFLLDRRPMVKRPTKAPPPIPQKPSGLSLNAGPVKILTEKISTKTVIKETTANGSTVTENVSTTTTSSTNSSWVKAMVGRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7R8</accession>
    <name>A0ABM5L7R8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518479.1">
        <property type="nucleotide sequence ID" value="XM_050662522.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662522.1">
        <property type="protein sequence ID" value="XP_050518479.1"/>
        <property type="gene ID" value="LOC126892793"/>
    </dbReference>
    <dbReference type="GeneID" id="126892793"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="443"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="531" mass="60656" checksum="25AC8A5F535CA8AE" modified="2025-10-08" version="1">MNHIVDRVNESMGFSFLGDDTPDIAGIEQSSICTRYLDKSDGKFIIREDFLCFITIADFTGKGIGTSYLNFLDSSGLNCTYFLGQGYDGARAVSGEFHGAQAVVRERYPLALYSHCAAHSFNLAVSSACNITAIRNCLGTLESIHTFFIYPKRQNALQDAINEDETLHESRLKKLKKNCKTRWVEQHESVATYLHLQPAVIRPLDVISTTWKDPTTSSGAFQLLSAINTANFQVKFKTHTSTLPALYYKMFVYSSFFEFNFQISMHILSSVHSLTLSLSRVLQSENQDLGEAIELADAAKQVLLERRENAEKDFRGIFKTVSEISAKYDIELRKPRLASKQTQRSNVQTDSVQDYFRITIYIPYIDLFLTHIQDRFLNHRKILSNFACLFPNKIKNFNEESCAQLFEPYSSILRDDSRDIWVDEVKLWRQRIAGKNVKNSLEALDVCNGDAFPNVHQMLRILAVLPVTTATNERSFSTLRRLKTYLRSTMSEDRLNGLASLNIHRDVEVDPQRVLEKFFSTPPRVNLLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7S1</accession>
    <name>A0ABM5L7S1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518485.1">
        <property type="nucleotide sequence ID" value="XM_050662528.1"/>
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        <property type="protein sequence ID" value="XP_050518485.1"/>
        <property type="gene ID" value="LOC126892795"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
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        <property type="entry name" value="Retrotrans_gag_dom"/>
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        <property type="entry name" value="Znf_CCHC"/>
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        <property type="entry name" value="Znf_CCHC_sf"/>
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    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
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    </dbReference>
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        <property type="entry name" value="zf-CCHC"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CCHC"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
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        <location>
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            <end position="374"/>
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            <begin position="2"/>
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        <location>
            <begin position="388"/>
            <end position="475"/>
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            <begin position="335"/>
            <end position="346"/>
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            <begin position="347"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518485.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="476" mass="55274" checksum="DF178F4A742543B0" modified="2025-10-08" version="1">MINSLTQIHENFQLEVSQLNNRIDTLDEKQKSLVNKIQQQQNSLVNLEQQQNDLKSNLERQIVELQTKINTQASLSHISVTNIDSEQTAPSSSIVYPGTVRTSKILKPPTFDGQTAWETYRFQFEAAAKANGWTEREMAASLVVSLRGQAATVLQFLPQDSPSYDSLVQALETRYGQQHLKQVFQSQLKVRYQKHNESLQEFEADIKRLLHLAYPQAPRDFLEQIGIQAFIDGLHDIEMQQALRLQHHKTLDKALISAQEYEAAKNISRSLPQLKEIRFTENKQVTTTDNEQLVLSQILSLLQNIQQKPRNENRRCFNCGRMGHLKSNCRSRSQARKEEYKNEIRRSPSSTSRSLSQSLTRNDGRWSLRNRFPTTDHRKEENTLEFEVSHLKEQLAISKNKIERLREQVTILQEECKVIQNNAKTTQSNLENKCQKLMKEKNVLNKQLQEYQNALNELQVQNQRQLAQKENVTEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L906</accession>
    <name>A0ABM5L906_DIAVI</name>
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        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518914.1">
        <property type="nucleotide sequence ID" value="XM_050662957.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662957.1">
        <property type="protein sequence ID" value="XP_050518914.1"/>
        <property type="gene ID" value="LOC126893018"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="HATC_C_dom"/>
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        <property type="entry name" value="IFN-induced_PKR_regulator"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="351"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="440" mass="50512" checksum="C2B809E870B70290" modified="2025-10-08" version="1">MQKKKHASKKRKQDSISTYFLGQGYDGARAVSGEFHGAQAVVRERYPLALYSHCAAHSFNLAVSSACNITAIRNCLGTLESIHTFFIYPKRQNALQDAINEDETLRESRLKKLKKFCKTRWVEQHESVATYLHLQPAVIRALDVISTTWKDPTTSSGAFQLLSAIKTANFQISMHILSSVHSLTLSLSRVLQSENQDLGEAIELADAAKQVLLERRENAEKDFRGIFKTVSEISAKYDIELRKPRLASKQTQRSNVQTDSVQDYFRITIYIPYIDLFLTHIQDRFLNHRKILSNFACLFPNKMKNFNEESCAQLFEPYSSILRDDSRDIWVDEVKLWRQRIAGKNVKNSLEALDVCNGDAFPNVHQMLRILAVLSVTTATNERSFSTLRRLKTYLRSTMSEDRLNGLASLNIHRDVEVDPQRVLEKFFSIPRRVNLLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-03-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2I6PIY2</accession>
    <name>A0A2I6PIY2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aubergine</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Piwi-like protein Siwi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114344326</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="journal article" date="2017" name="PLoS ONE" volume="12" first="e0190208" last="e0190208">
            <title>Distinct fitness costs associated with the knockdown of RNAi pathway genes in western corn rootworm adults.</title>
            <authorList>
                <person name="Wu K."/>
                <person name="Camargo C."/>
                <person name="Fishilevich E."/>
                <person name="Narva K.E."/>
                <person name="Chen X."/>
                <person name="Taylor C.E."/>
                <person name="Siegfried B.D."/>
            </authorList>
            <dbReference type="PubMed" id="29267401"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0190208"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="MG266017">
        <property type="protein sequence ID" value="AUM60044.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150966.1">
        <property type="nucleotide sequence ID" value="XM_028295165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498381.1">
        <property type="nucleotide sequence ID" value="XM_050642424.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498382.1">
        <property type="nucleotide sequence ID" value="XM_050642425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2I6PIY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642424.1">
        <property type="protein sequence ID" value="XP_050498381.1"/>
        <property type="gene ID" value="LOC114344326"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642425.1">
        <property type="protein sequence ID" value="XP_050498382.1"/>
        <property type="gene ID" value="LOC114344326"/>
    </dbReference>
    <dbReference type="GeneID" id="114344326"/>
    <dbReference type="KEGG" id="dvv:114344326"/>
    <dbReference type="CTD" id="34524"/>
    <dbReference type="OrthoDB" id="445936at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140965">
        <property type="term" value="P:secondary piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="323"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="10">
        <location>
            <begin position="597"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AUM60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028150966.1"/>
        </source>
    </evidence>
    <sequence length="899" mass="101417" checksum="4CEE117DA885D4D0" modified="2018-03-28" version="1">MESRGGKGRARGRARGAPQGGGPPGGAPRPGPPGQQGPGAQGPPQQNRPPGDPWSRAAAPPQQQGPPAAQMGPWVRPQMPTPAAPVVGAGRGSRFGGGETGEVSAPAEHARAVQGAGDGEKSRATSSGVRGRNLKYEIIRTKPADMQSKKGTSGQPINLISNYFPMIQAGKFLLFQYRVDFNPDVDHTGARKKFMHIALKDTLNGYLFDGTVLYTAARIQPDPLEKFVENEAGEKVRISIRMVSELAWGDFHYIQLFNILIRKCLSAMKLTLLQRDYYDPQSQVNIHEHKLSLWPGYFTSIRQHENQVMMNIELAFKVLRDDTCYNMFLDCRGPEPKKEFQSKIIGSSVLTFYNNRTYRIDDVDFSQNADSTFPLRDGSQMSYAQYYSEKYKIHIREKRQPLLVSRSKPREIRAGMPEVVYLIPELCKPTGLTDRMRENFRLMQALAEHTRVGPVDRMRKLQEFCKRFLGCAEAVTELKKWDFKLADRLVQFQGRVLPMETIVAANNARYAAGPKADWTRDLRAQRMFNSANMTRLVTICPSRQKNECQDFLQTLQKAARGMQWDIGRPEIFDIPDDRTNTFCTAIENVAARMDPTLIMCVLPTNQADRYGSIKKKCYVDRGIPSQIVLRKNLTSKGVMSIATKVAIQLNCKIGGAPWSIVMPLSNVMVVGYDVCRDTLKKQSSFAAMVATLDRAMTRYYNHVTEHQLQEELSENISAFLIVACQKYKEVNGRYPERILIYRDGVGDGQLPFVFTMEVERIKEKLTSEIYKNGDLKMSFIVVSKRINTRFFTPNSNPPPGTVVDDIVTLPERFDFFVVSQCVNQGTVAPTSYNVLSDNMGLSPDRLQMLTYKLCHMYYNWSGTVRVPAPCQYAHKLAFMTAQHLHRPANRALETLLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYV1</accession>
    <name>A0A6P7EYV1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114324791</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028128439.1">
        <property type="nucleotide sequence ID" value="XM_028272638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYV1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272638.2">
        <property type="protein sequence ID" value="XP_028128439.1"/>
        <property type="gene ID" value="LOC114324791"/>
    </dbReference>
    <dbReference type="GeneID" id="114324791"/>
    <dbReference type="KEGG" id="dvv:114324791"/>
    <dbReference type="InParanoid" id="A0A6P7EYV1"/>
    <dbReference type="OrthoDB" id="434041at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17943">
        <property type="entry name" value="DEADc_DDX20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="52"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="258"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="647"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028128439.1"/>
        </source>
    </evidence>
    <sequence length="934" mass="105467" checksum="42ADF9AE200B4F5A" modified="2020-12-02" version="1">MLAHQIENDSRSQDVVVVENVTFDSLLLSGKVAQGLTKNGFKKPSPVQLKSIPLGRCGFDLIVKSKSGTGKTLVFSLIALESLNSTKLKKLEVLILAPTREIAVQSHDFIKQIGCFFEGLKVESFIGGLPLAEDKQKCQNCNIAVGTPGRIKHLILDKTLNVNSVKLFVLDEADKLMESSFRNDINEIYNSLPTKKQIITTSATYPNQLEEFLSKYMLSPTHITAELESPLLLGLKQFVVVTKPYSNVAQQLKAKTDALVDIFNNISFTQCLVFSNFQTKAESLSNILNQKGWPSTYISAAQTQEQRLEAVSVLKEFKCRIMLSTDLTARGIDAANVDLVINFDIPIDSMTYLHRMGRAGRYGSSGVCINLTSQGKELTHLQEILGQIGGNTLTIPKLPKINGSISDLLKIEVPLTDHIASKVKNELDESITKTKMYENKTKQKSPNKDNDDPARSEGVHDDQEAISQNISDDDQEFVMVHIDQEAIPQNIGLTDILQNTQQEIEEVRKQISEMDTESILHSLLNQNLNIEVPSNNSLKTNTNKPFDAQAVLDVLKEGCKPTTTKNDDNYKKTVPKVDAEEELKENLLTKNKALLSTSQILSNSSITEGPFCIEQHLKVVKSQFKNEISELSKNSVSDILKIINTKENPKKSDDKPKQDGTGSFDVPSSSKSSKLPKQKSDDKPKPDSTGCLDVPSSSKTCHEEESESESLFHLGYKHLVLSDNDDWKEVLKKRCDADTSVKSNTPSYRRTSSESDQEVKHKKHGKPRRYSAVHDESSSQSEPMDSQMVWSSNPEENSMLEMEWRRQEVAMRWIPVEEEYYEEANVMEHTDEEMEWRRQEEAMKWVEVKTPRTANHVTPTCVLELRKGSNDAEYGHYSSYMEQLDDKLWQNGLEFNSSESFNDWFSFEWELELQATRNYIEQNIYVSEMNKFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1B4</accession>
    <name>A0A6P7F1B4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cuticle protein 16.8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325289</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129111.1">
        <property type="nucleotide sequence ID" value="XM_028273310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1B4"/>
    <dbReference type="FunCoup" id="A0A6P7F1B4">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273310.2">
        <property type="protein sequence ID" value="XP_028129111.1"/>
        <property type="gene ID" value="LOC114325289"/>
    </dbReference>
    <dbReference type="GeneID" id="114325289"/>
    <dbReference type="KEGG" id="dvv:114325289"/>
    <dbReference type="CTD" id="37319"/>
    <dbReference type="InParanoid" id="A0A6P7F1B4"/>
    <dbReference type="OrthoDB" id="6358661at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027575990" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129111.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20100" checksum="BE2F86BA30DB2352" modified="2020-12-02" version="1">MKKSLIILPFLLSIGLCDVHLLVPEEHTPPPPPKPYAFGYAAGRFPGHIDRTHSEVSDGSGLVQGSYSYVDPKFRIRKVDYVADKDGFHVTSNDDVPALPSDTPVVAAAKINHLRKYAAIADAQQASPGQVFVPADTVAVQYAKNKHLSLYEKIAADHARIAAELEAAKHEEGHGNEVGDGLYGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1E1</accession>
    <name>A0A6P7F1E1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box/LRR-repeat protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129419.1">
        <property type="nucleotide sequence ID" value="XM_028273618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1E1"/>
    <dbReference type="FunCoup" id="A0A6P7F1E1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273618.2">
        <property type="protein sequence ID" value="XP_028129419.1"/>
        <property type="gene ID" value="LOC114325540"/>
    </dbReference>
    <dbReference type="GeneID" id="114325540"/>
    <dbReference type="KEGG" id="dvv:114325540"/>
    <dbReference type="CTD" id="43475"/>
    <dbReference type="InParanoid" id="A0A6P7F1E1"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000556">
        <property type="entry name" value="CLUMA_CG018969, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000432">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129419.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="59498" checksum="A37A4C00CCCC91B0" modified="2020-12-02" version="1">MDAWGNFTLGNLDVPTIRDDELNIQGSFRRKKPKTTIEKLPDKVLLHIFSYLAHKEICHMARVCRRWRLIAYDTKLWKNVSLRPEISGLHVGSLEALLALVSIRFGPSLRYIELPIELITHTVLHELANKCPNLTHMLLDFSTAMQLHDFSELQAFPTKLKYLCICLSEVIFMEGFMRKIYNFINGLEILHLIGTYEKVEEEEEEIYEVINVHKLKSATPNLRVINLYGINFVDDSHIDAFSSNCIQLECLAVNYCNKVTGSTLKTLFQRSRRLKCLLMNGTNLQSEYLMQVEWEKCSVQELDITATDLSTEALQDMLTRIPGLRFLSAGQLNGFNDSVLKSWMESGTSRNLIALDLDSSDNLTEEAIYKFLCKHGQQLLGLGLSGMTHITDSLWQSVLPILTNAKILVMGTQERLGVNILADQLMDSIARNCLNLERLELRWDPDNLRFSDKSQKAIDTLRVKCLKLRCLCLSDGRYYEVVKANFERADRMTVVRTLTNCRISNYYLLSNYKDLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2I2</accession>
    <name>A0A6P7F2I2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC114325628</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129536.1">
        <property type="nucleotide sequence ID" value="XM_028273735.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129537.1">
        <property type="nucleotide sequence ID" value="XM_028273736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2I2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273735.2">
        <property type="protein sequence ID" value="XP_028129536.1"/>
        <property type="gene ID" value="LOC114325628"/>
    </dbReference>
    <dbReference type="GeneID" id="114325628"/>
    <dbReference type="KEGG" id="dvv:114325628"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="549"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028129536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028129537.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91232" checksum="17B293531B949541" modified="2020-12-02" version="1">MKNKETFKDARILFSIIKAKYPKYHPFWFILYMYILYIRTLKRQYLYNLRPVPTDFIIKYVKNKSYFKDIHSTVIVNTHNIYTSDKVLKLYCDKTKLTRIVYTVPLAGCDKHELLVSNTFFQNLSNINLINSLRLLCCSLDQSKIAQEINISLISCPFDINNSLSDALLERYFKKPKLLRKGDLIEINIKYIAEDIYFLNSKVNNVHSVFFKCNKVIYQEKEVTESVCCVLGETAIRQSVNLQSFVPKITSKVVPNSKEEFKELCLCPYGLQNYFQEMQMAVKPFLRKQRLSLKPTFLVTGNAGSGKNIIVSSLAAELGMHYYRIDHYELMANVYAQNETKLHNTFFTAKLAAPCVIALHNFENFGKNNDGQFDERIMGNFLDELDFLFENNTFPVLLFCCSNQKEIPPDLKKLFLQTFDICTPSDLEREQHLRWICEERNIETDVDFSEVANKTHGFVFEDLRALVYYAERNCGRKLCDSKTFKIDMRDFDKAVDYMQKNYNESIGAPKVPKVLWSDVGGLTDIKEEINKTINLPLRHPEIFRTSGLRRSGILLFGPPGTGKTLIAKAVATECNLCFLSVKGPELLNMYVGQSEQNIREVFERAREASPCIIFFDELDSLAPNRGISGDSGGVMDRVVSQLLSEMDGLNDSATIFIIGATNRPDLIDPALLRPGRFDKLLYVGPCTDDISKTSVLKALTRKFKLDDQVDLTEVVRVCPKNVTGADFYGICSNAWMFAVRRLIKQIEAGDVSAEEAASDDVIVNFEDFKQAMVNVKPSISPEDLLYFEKLKMELGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAH4</accession>
    <name>A0A6P7FAH4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114327392</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131792.1">
        <property type="nucleotide sequence ID" value="XM_028275991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAH4"/>
    <dbReference type="FunCoup" id="A0A6P7FAH4">
        <property type="interactions" value="1232"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275991.2">
        <property type="protein sequence ID" value="XP_028131792.1"/>
        <property type="gene ID" value="LOC114327392"/>
    </dbReference>
    <dbReference type="GeneID" id="114327392"/>
    <dbReference type="KEGG" id="dvv:114327392"/>
    <dbReference type="InParanoid" id="A0A6P7FAH4"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028131792.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32849" checksum="C73B53289E76F7F5" modified="2020-12-02" version="1">MGLCKCPKRRVTNQFCFEHRVCVCENCMVTNHTICIVQSYLQWLQDSDYNSICELCSKELSSQDCIRLTCYHVFHWSCLDHFSRQLPPTTAPRGYTCPSCKSPLFPPSNLISPVADVLKEKLAGVNWARAGLGLPLLSEEREIKSTINHNMSMPPRITPSPAHSVVSVDEDIGAFNRADSFQHSSNRRIFQDIRDIKPDVFDHDDNKYKRKPISELFGNWFKITFGAPLRARGRKSVCRRYCMLGALVIFIIVMFFFVMSKLSRYSIDDDPNFDVRHNELVKTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB45</accession>
    <name>A0A6P7FB45_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114327549</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028132022.1">
        <property type="nucleotide sequence ID" value="XM_028276221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB45"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276221.2">
        <property type="protein sequence ID" value="XP_028132022.1"/>
        <property type="gene ID" value="LOC114327549"/>
    </dbReference>
    <dbReference type="GeneID" id="114327549"/>
    <dbReference type="KEGG" id="dvv:114327549"/>
    <dbReference type="InParanoid" id="A0A6P7FB45"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028524151" description="CLIP domain-containing serine protease" evidence="11">
        <location>
            <begin position="29"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="13">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="137"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028132022.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44014" checksum="9BD18E2CEF4C4F19" modified="2020-12-02" version="1">MCCEYQNMVLLYFIYLLVFFLMNSHSNGQDVCTAPDGTKGSCIQVRSCPNFETALRNVKRPLSDTARKQIKAYVCNENFTKVCCPKEPIIIRELLVRTSGNESSTGTLTDVTKHRNYGLLPTDCGFIDFSNLISTKVIHGEDAGLYEYPWMSLLSFRLPGNIRKFRCGGSIINNRYILTAAHCLEDKSNLLGVRVGEYNLSNKGTDKDCIDTDCNYPVQDLAIEEIISHPNYESKEKKNDIGLLRVQPITFNNKNVRPVCLPRTSNADFNQTYPEVSGWGITKFGARTSKVLQKAYLKVVNPVECQNFYQDSLSTVIDDTRICAGGVLQTNKSNACTGDSGGPLQVQEVSPDNERKYVQHGIVSAGVTRCDYPSLFTKVDYYLEWILDNMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG84</accession>
    <name>A0A6P7FG84_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114329110</name>
        <name evidence="12" type="synonym">inx</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133927.1">
        <property type="nucleotide sequence ID" value="XM_028278126.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515534.1">
        <property type="nucleotide sequence ID" value="XM_050659577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG84"/>
    <dbReference type="FunCoup" id="A0A6P7FG84">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659577.1">
        <property type="protein sequence ID" value="XP_050515534.1"/>
        <property type="gene ID" value="LOC114329110"/>
    </dbReference>
    <dbReference type="GeneID" id="114329110"/>
    <dbReference type="KEGG" id="dvv:114329110"/>
    <dbReference type="InParanoid" id="A0A6P7FG84"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF38">
        <property type="entry name" value="INNEXIN INX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028133927.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="48051" checksum="14B9A1A94DF92191" modified="2020-12-02" version="1">MLSTFEGLKKNFKLKPQQYIIDNWVFRLHYKATVYIFIISSILVTSRQYIGEHIRCIADGGVPEHVMNTFCFFTTTFTVPYVNATKENLEKLLETKEMSAHMLDTGNLAHPGVGPYGIDSNEPIVRHAYYQWVPFVLFFQGLMFLIPHLLWKKMEGRRLRYLVDSLKYAAFSLQEKEVKVGDNKIPSKSDREKKIQQVRQLFQDGVYVNKNWALKLMLVEVLNFIHVIIQIAITNRFLGYKFLKLGSTVWRNGLDSSVDILDEVFPKITKCTFHKYGPSGSIQYHDAMCVMALNIINDKIYTAVWFWFIFLFICSILGLLWRIITYILHARSRGFNRMIFSSSCPGKLNPWRVLNVTRTPSYSDWLFLVYLSKNVDPLVFKEIFVGIAQDYEERSSMKKPLLDLEDSDLKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH30</accession>
    <name>A0A6P7FH30_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330120</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135231.1">
        <property type="nucleotide sequence ID" value="XM_028279430.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499289.1">
        <property type="nucleotide sequence ID" value="XM_050643332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH30"/>
    <dbReference type="EnsemblMetazoa" id="XM_050643332.1">
        <property type="protein sequence ID" value="XP_050499289.1"/>
        <property type="gene ID" value="LOC114330120"/>
    </dbReference>
    <dbReference type="GeneID" id="114330120"/>
    <dbReference type="KEGG" id="dvv:114330120"/>
    <dbReference type="InParanoid" id="A0A6P7FH30"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF309">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135231.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50353" checksum="245B1C3201B6CAE1" modified="2020-12-02" version="1">MEKSPEKVPPEGGWGYLITLAVFIAHLSTVVPLASFGIVHGKFLASLGDETAGTSISTSLFIAVTCSAGLFGGILFNTYSYRTVGLLGAVLHLIGSILLVFAETLFQFIVCLSIIQSFGGGLLLPSAFSSLNEYFHKKLSLQTAIAQILITVATVVNPLVMTYCVHSYGYKTTKIILIGYSLVNFFGMWSLHPVEWHTKTEKDKASSDQKNIRDHAEKGALLGGEKEIVFYCFIDQEKHDKERQIEESTSTYMSYFDLLKSAKYLNIAIGTSLSFHGDNLFIGMLASVLRSINYSSIDIAKLTMVHFGCDLITRIIYASLSAFYSFNNRYLVYGSTLLTAIFRILFVINDGYSWRMAILVILGILRCFIQTPYSLVIAEAYRDNFARAFTLFCVLSGGTSLVLGPLMSLLKGLTNNDNIAVQVLTGGMLLSVFMWTLEFVYIKLSNKNRASQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FL96</accession>
    <name>A0A6P7FL96_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114328950</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028133743.1">
        <property type="nucleotide sequence ID" value="XM_028277942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FL96"/>
    <dbReference type="FunCoup" id="A0A6P7FL96">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277942.2">
        <property type="protein sequence ID" value="XP_028133743.1"/>
        <property type="gene ID" value="LOC114328950"/>
    </dbReference>
    <dbReference type="GeneID" id="114328950"/>
    <dbReference type="KEGG" id="dvv:114328950"/>
    <dbReference type="InParanoid" id="A0A6P7FL96"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028133743.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38546" checksum="7307CB8AC3AFB970" modified="2020-12-02" version="1">MSIVQDNVMSHCCSLVHLKVMESLYFFMYSFKMGQTLSEPVTAKDTSCCQDSSFRVGSSCMQGWRINMEDSHTHILSLPDDPNAAFFAVYDGHGGAEIADYAGKHLHKFVVKRQEYKDGDIPEAMRQAFLELDAHMLEEECIFSKPSGSTAITTLIKGDKLFCANVGDSRAVASVNGSARALSEDHKPSNQAEYDRIIAAGGWVDANRVNGNLALSRALGDFAFKKNGKMPAEQQIVTAFPDVTEHTITSDWEFIVLACDGIWDVMSNKEVVSFIRENIATGHEPEEICEELMMRCLAPDCQMAGLGCDNMTVVLVTFLHGESYEKLQEKCKQPPTEHVDAKDQDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNY6</accession>
    <name>A0A6P7FNY6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interaptin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329715</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134698.1">
        <property type="nucleotide sequence ID" value="XM_028278897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278897.2">
        <property type="protein sequence ID" value="XP_028134698.1"/>
        <property type="gene ID" value="LOC114329715"/>
    </dbReference>
    <dbReference type="GeneID" id="114329715"/>
    <dbReference type="KEGG" id="dvv:114329715"/>
    <dbReference type="InParanoid" id="A0A6P7FNY6"/>
    <dbReference type="OrthoDB" id="419631at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="709"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028134698.1"/>
        </source>
    </evidence>
    <sequence length="858" mass="102138" checksum="A21F6B75D3572C13" modified="2020-12-02" version="1">MSFSKAKIQRFNDVKASIAAGKQNAEKPKVKPKPVLQQPCDIKPEKATSDTASSQSVPCFRTPNLLKKKLKLTVPPIGTTPKPTTLFPTDPNIDALKEKIVECENKDAYIKDLTQQLEEFRDIICRIQRENEHIQNEKEKHERIVEDLRNSHQLHLQSIQTEFHKKLIETLSIKERISDQLIALREDFKNFQMFYETNVQDLKNHCSEMPMYFQKYSDHYQILFEQKEAAMHHQENMVKMLERSSIEMQKKHSLEIEKLRKEQQIEIQDLEFELLKTMTELQKEKENSSIQIKEMEEMMNNKLLEMREVFQQDKQNIIHNSELKIKEMEETLKSNSNWEDQMNEQLSQQEIVWKNKLNEQQKQSDDILKECQTISEYHIIQCTIEKNAVVCELKENIEEFKRVKNKYEELTNDFKKLTATYNELKTELKLKEQQTKEAKKKLQAEIEQYSKKLKQTLNEKSAYEYTIKNSQVTIEVLTKRLIHSDKDVEQLKEELSDCEKKLLEYEQKNLQLIADLKQAQVSNEELEMQFESTIKINCKDIENMGSKLSKEVDEYKKEVIKYKQRFTDEQKLNKEIMQQVHDAYDMINRLKMELEDAETIYSQYKFEIQQSQNELEDYHMREMDWNIIKDKLESTVKELEDLLSSKNHEITDLKKKVSLLEQKSDSILQYSDYYKQKVKELELDQAETNKIHKKYIELSGKYDCLSYKYEELESEILQHKMRLVNVSEKKDEGDWKVKYDTQVTVCSELEQKNAKLEQELQKRLKDESTLKSDCIKMKVERDALTMKVQQLENEILQFTLNEKPRTPKTSKKFKTEDQDPMKLFKKNKHPKEDKENIGSPNRTLNNSSRIDSPLRDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSU0</accession>
    <name>A0A6P7FSU0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114333640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114333640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139371.1">
        <property type="nucleotide sequence ID" value="XM_028283570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663639.1">
        <property type="protein sequence ID" value="XP_050519596.1"/>
        <property type="gene ID" value="LOC126893438"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FSU0"/>
    <dbReference type="OrthoDB" id="6781944at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028139371.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42786" checksum="F90A1092EB005151" modified="2020-12-02" version="1">MITYTVYSSTCEGKKSSRASTNTEPKVNSKYQANDSRHIRSSSSFVTNSSSVCCALCKQSHYLKQCLLFLKKSPKERYQFYKEPSSCFKCLNQANHSVKSCPKSFKCSSHLHNSLLHFDRDRCNSQWSSENNSPGTSGIESSPEVSHCAASFVEKKHETKKEILLGTVLVHAIDSKGCKQPMRCLLDSGSMSSFISRKDANRLGWPKTPCSFEITGLNSMQTKLNHGQISFSIQPRHQESPVFHLVAIITDRVCSDLPSTQVNVSAWNYIKNLKLADPKFNCSQSVDLLIGCSIFSKVLLEGKIEGKPGQPDALNTVFGYILLSPTSTPNLTSTSLVCLSNLEDSLGSSLRKFWELENIPEEPVSEPEDVLCETIFRETHSRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTA2</accession>
    <name>A0A6P7FTA2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114333749</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114333749</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139541.1">
        <property type="nucleotide sequence ID" value="XM_028283740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTA2"/>
    <dbReference type="FunCoup" id="A0A6P7FTA2">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643357.1">
        <property type="protein sequence ID" value="XP_050499314.1"/>
        <property type="gene ID" value="LOC126879958"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FTA2"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF3">
        <property type="entry name" value="LD12305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028103954" evidence="3">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028139541.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25289" checksum="41B368CA927E40A4" modified="2020-12-02" version="1">MKSTILCFALMGICVAQLQNQRILEAPVPTLCSQRIIHERTPDGKGYFFSWKDQNTKGVEQDWLSTRNYCRKRCMDLVSLETSAENEWIKRHIVEDKIKYIWTSGRLCDFKGCDRPDLLPNNVNGWFWTAVLQKLAPTTQRDQNDWSETGGIGKPQPDNREVIQQGGAQENCLAILNQFYNDGVNWHDVACHHVKPWVCEENEDLLKYVRYTNPNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTY8</accession>
    <name>A0A6P7FTY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114331148</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136433.1">
        <property type="nucleotide sequence ID" value="XM_028280632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTY8"/>
    <dbReference type="FunCoup" id="A0A6P7FTY8">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280632.2">
        <property type="protein sequence ID" value="XP_028136433.1"/>
        <property type="gene ID" value="LOC114331148"/>
    </dbReference>
    <dbReference type="GeneID" id="114331148"/>
    <dbReference type="KEGG" id="dvv:114331148"/>
    <dbReference type="InParanoid" id="A0A6P7FTY8"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901858">
        <property type="term" value="P:regulation of mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028136433.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20722" checksum="B36A8674C85C3EA0" modified="2020-12-02" version="1">MNIIKSCMKYYTGLLKTNFVLVQSVQSGLLCGSGDVIAQVVAERKNIDLHRTGCFLVLGSCFIGPVITVWYRFLSRKLGDKGKFVALKKVAADQLLFVPPFQIALISTINIIQGRNLEFTKEQLRLKYTDILIANYKLWPAVQIVNFYFVPLNYQVLLVQSVALFWNAYVSWKTQYGIVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW83</accession>
    <name>A0A6P7FW83_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334849</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140764.1">
        <property type="nucleotide sequence ID" value="XM_028284963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW83"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284963.2">
        <property type="protein sequence ID" value="XP_028140764.1"/>
        <property type="gene ID" value="LOC114334849"/>
    </dbReference>
    <dbReference type="GeneID" id="114334849"/>
    <dbReference type="KEGG" id="dvv:114334849"/>
    <dbReference type="InParanoid" id="A0A6P7FW83"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="435"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140764.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="68100" checksum="B846FA16D50A74F5" modified="2020-12-02" version="1">MFSRGTKVHSSSYSRKFERKPLSDTHKTFLSYGHDCTLEDIADNYDYDYAPGKSLFSRLRRWLVKMRVVSESSKFYTHHLRSFGAISAERRRHLKKHPYAIHPFSTGRVVWAIIMIIVITYQFIFTSFLYLLFDFRDPNYSFPDTINILRLIFDSFLMLNVVLNCFTGYYNEPMQKVVLDGRSIMKYYLSTNLIPDLLSSFPFYLDIFVPMCTQHKAIVLWLTLFRYLLARSFMSYSKIIASYFQIRHFKYMTTMVIVNTTLFWHIMCCVIEFIRANIIYYTRFEAFYDKSEEGYFINDNFWIKYINALHHKSLLLYNSGYGKVIPKAELEIILVFLVWYGSSLFCIYILAMIMEINTGNTSSILKYDAMERQLKEYMRHKQLPSQMRSRILTYYEFKFQKKYFRENEILATISEQLRQEMNMHACKKLVENVTFFRNLPLNLLVRIISCLKIEVYLVNDLIIRVNTPGTSMYFISTGTVAIYTKTGKEVCHLEDGAHFGEIALLKKNTFRIASVVAVEVSEIYRLDQKDFVKAINPYPDLLASIQHIAEERMEVTSMLDESNKRDVISSQLKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYQ0</accession>
    <name>A0A6P7FYQ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114332353</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137943.1">
        <property type="nucleotide sequence ID" value="XM_028282142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYQ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282142.2">
        <property type="protein sequence ID" value="XP_028137943.1"/>
        <property type="gene ID" value="LOC114332353"/>
    </dbReference>
    <dbReference type="GeneID" id="114332353"/>
    <dbReference type="KEGG" id="dvv:114332353"/>
    <dbReference type="InParanoid" id="A0A6P7FYQ0"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000004">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="172"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="363"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028137943.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="74821" checksum="D95D9584D0A2B360" modified="2020-12-02" version="1">MFLNRILVPTVNRLFQKFTPKMPNMLKVVQTCRPRSSFSGLRGGMALFEQMLKLEDVNCCRTLTQQRRCMSKRSHHHKGSGRAVPEKDHIGIWGNNHGDHCFPSMESGIDRLKNPGLNKDLAFTLIERQLLGINGLLPPMVKTQEEQIQNVRTNLNRFKDPLNKYLWLMDLLGRNEKLFFATVRKYVVDYLPILYTPTVGAACQNWSWVYRRPRGVYITIHDKGHVYEILKNWPEYDVRAIVFTDGERILGLGDQGAAGMGIPIGKLGLYTALAGIKPHQCLPVTIDAGTNNEKHLKDPLYLGLREKRHRGKEYDDLIDEFMEAAVERWGQNVLLQFEDFGNSNAFRFWEKYRNKYCTFNDDIQGTASVVVAGLIAAMKLTGNKITDHTLVFQGAGEANIGIAELCVYLMCKSGMAEEEALKKIWMVDSQGLIVKGRDKIVGHKKKFAQDHDPIKQLSEVVKKIKPSILIGAAAVPGAFTTEIIHEMAKNNKRPIIFALSNPTPKAECTPEQAIKETKGSVIYASGSPFPPVQYEGKTFHTGQANNSYVFPGIALSAVTGGILHFTDEHFYVTAQTLADLVKEEDLKVGRVYPPLETILEVSVKIATKLVEYSYEQCIASVYPEPRDKEAFIRAQMYCTDYEPVYPCPYDYPKEKEVKNKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G074</accession>
    <name>A0A6P7G074_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab-38-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114332892</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138478.1">
        <property type="nucleotide sequence ID" value="XM_028282677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G074"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282677.2">
        <property type="protein sequence ID" value="XP_028138478.1"/>
        <property type="gene ID" value="LOC114332892"/>
    </dbReference>
    <dbReference type="GeneID" id="114332892"/>
    <dbReference type="KEGG" id="dvv:114332892"/>
    <dbReference type="InParanoid" id="A0A6P7G074"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028138478.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25939" checksum="898EDFFD6DF339DE" modified="2020-12-02" version="1">MNGPRLGLSREEIIKISETIRENNLNKQELIFKIVIIGDYGVGKTSIIGRFTEGQFSTQYKITIGADFAVKTLEWDEDTRISLHLWDIAGNERFGSLLSVFYRHAVAAAIVFDLTRPETFNSVSKWLTNLRKKLHLPGGRTVPIVILANKGDISTTTLPPQIDEYCRNNDILAWYVTSAKKNINIDEAMVKLANAALNNHFALKLSLATDEDIINLTENNQQETNQKRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G417</accession>
    <name>A0A6P7G417_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor capicua isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114335679</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141757.1">
        <property type="nucleotide sequence ID" value="XM_028285956.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285956.2">
        <property type="protein sequence ID" value="XP_028141757.1"/>
        <property type="gene ID" value="LOC114335679"/>
    </dbReference>
    <dbReference type="GeneID" id="114335679"/>
    <dbReference type="KEGG" id="dvv:114335679"/>
    <dbReference type="CTD" id="23152"/>
    <dbReference type="InParanoid" id="A0A6P7G417"/>
    <dbReference type="OrthoDB" id="10051111at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21990">
        <property type="entry name" value="HMG-box_CIC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000010">
        <property type="entry name" value="Capicua transcriptional repressor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032147">
        <property type="entry name" value="Cic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058607">
        <property type="entry name" value="HMG-box_Cic-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058606">
        <property type="entry name" value="HTH_Cic_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16090">
        <property type="entry name" value="DUF4819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25981">
        <property type="entry name" value="HTH_Cic_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="810"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="810"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="882"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1441"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1522"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1445"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1524"/>
            <end position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028141757.1"/>
        </source>
    </evidence>
    <sequence length="1546" mass="170793" checksum="F492689DFD0F0EE0" modified="2020-12-02" version="1">MEMGVRKLPKKRKFDPSELEENNSQAACIPISVVQCHSVMSAPQATAVDYSYPARTSTQEETIFTHTNCKQNIVIDLGEWCNHRILARQGDWYYPGVIKEAYGSTIIVALDGKEDKITYDNVFDNECFNVISDASPSVNQITMGTRVCVRDNQSMFVEGVVCTILEGQPVRFGVALFGEQSVELTVKRADLRLLRPPWWDELENIEPNLDNVIQPSLDFYGRNAQVSPMQLHTPISACTPLSNGRHYDEFCESEDELRQDNITFNPEVDAKLSGSSKRSSMHSRGSSSRSITPRSQPTTPRSQAATPHKYRKGDVVCNPNGIRKKFNGKQWRRLCSVDGCKKESQRRGYCSRHLNLKGNSLRSGPYPRSNSKGDGEETSRDSETSPNCGDRRMTGRFDQEETDAANMLVSLGSSRSATPVFSPNGQGSSPHTMQSPITVGSRQNVFMPISGSHSLGLQKGASPGAQGYNPTTYHQQVVIRPEARPVQSVTSVIRVSPNPRQWIPEQPSVILQHALTSPPSQHVEPETNQVTQGGLYYVVPPKHDKNMMIVKNETENDPKEPKSFPRQVIQSDHLHSTQLIRVNPSNNYANMNNIQTHSNGPGIMAPNSINTGLPVIVNPTQLVPVLPSTSQSVVKRVVPTVNIQPNPPPVIVKTEQVSPNTNAVLNHLKEPMVLHNPLQVQSHRVATVPPQLPLPQLNQSQTRSININVNPWHSILPLLVSSGPLSPPNSQLSPPLSTSLVTVDGGAVLDNPDDDADAEPLPTPTEDDDDDVFESETTDLNMDGNIKRRSQSLSSLQSNSKEASKSKERIRRPMNAFMIFSKRHRGLVHQRHPNQDNRTVSKILGEWWYALGPNEKKQYHELASEVKEAHFKAHPEWKWCNKDRRKSSTGSGRSKLSSAGDSGEPGDMPVSPKAPSPPPPNIEPCKQVVQEQETGDASDDDQMVICEDAGAEIDLKCKEKVTDSDSESQSDMDSSIENRVFQRFSPMTNSNCTEVTCRPKPIKARIPSTETPKYSLTATATPFHYSPVNPSGISGFQPTGGAFKTMPASPKIVKSEVKNEFSENHESYAGTLIINSTDASKWSNSSAIQTSTLTSQTNSTLVIPKSEVKTNIIQSNDGINQTYQSQPLTVVIGRPTNTICLSNEHEQTQPFVVIASTASEIPVQLYVQPSFGIPVSNSNNRNLSVQNVQLIKPNTQSVIVTQAHNKVCVSSQVEYQAAQSTVMASNKNSYCNNTGTLLHITEANDHREDNNKSPVLEMFPPNSETFMLDQTNQEFKLAPTPAQLGKAPLQRRQTMAAFGNKDSQGEQDLLPAPANPILDENIDLISPSTKKTFFKRSVEDGMDSLFYRVLEQVNFEQKFTALPQFKPDEGQSPSAISIPSPGVFYNKKRSQLTATHGVTIEEESEAETPQSIPKSAASTKLVIGNQFFGPDFDNVRAELNEMEEGTSPRTPRTPGTSRDSEKGHRKTLEQRRQLVMQLFHEQSFFPSSQATSTFQAQHSDIFPNKASLQLKIREVRQKIMAQNSLTPSSVSSPLTPAEPVRVSSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G422</accession>
    <name>A0A6P7G422_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114337454</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028143686.1">
        <property type="nucleotide sequence ID" value="XM_028287885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G422"/>
    <dbReference type="FunCoup" id="A0A6P7G422">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651052.1">
        <property type="protein sequence ID" value="XP_050507009.1"/>
        <property type="gene ID" value="LOC126884808"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G422"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028143686.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24527" checksum="1C4C082753FFCB69" modified="2020-12-02" version="1">MTSPTEKSYKIRDATKADRDAIVEFLRISFFRDEPLNAFLELVTEENPTCETLEEFTVGHIPNGINLVAIHNDQIVGLILSTPLEKVQEEQYDCKNEKYNKLVRLLDYAAKHADPFVIYPSSTKGISVQVISVRKDFTGRGLAVELLQKTCDLAQQQGYDFVEIACTSLYSAKLSEKLNFDLKYSLKYTDYKENGEIVFKPESPHTTLNVYLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4T3</accession>
    <name>A0A6P7G4T3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein obstructor-E-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337726</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144049.1">
        <property type="nucleotide sequence ID" value="XM_028288248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4T3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288248.2">
        <property type="protein sequence ID" value="XP_028144049.1"/>
        <property type="gene ID" value="LOC114337726"/>
    </dbReference>
    <dbReference type="GeneID" id="114337726"/>
    <dbReference type="KEGG" id="dvv:114337726"/>
    <dbReference type="InParanoid" id="A0A6P7G4T3"/>
    <dbReference type="OrthoDB" id="9987187at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027783533" evidence="6">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028144049.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23505" checksum="733C0EF922A67F9C" modified="2020-12-02" version="1">MEFYWIAMLMLVLQGVDGKHLVQKNLKLDSSPERSSEEKHNTNSCKIENQQTAHESRCDLYYRCVYGVKVQKECPAGKLFNTQISNCDNSYNVDCNNRIHNNVNKLVVRSFDFYDPDETTTLDLSDQEVSVESGECPEKKDPYEPSALLPHEESCNHFYKCINGKKVLMKCPKPFQFNFKVSACDWPQNARCYNRKIDTTTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5A0</accession>
    <name>A0A6P7G5A0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidoglycan-recognition protein LA-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114333899</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139700.1">
        <property type="nucleotide sequence ID" value="XM_028283899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5A0"/>
    <dbReference type="FunCoup" id="A0A6P7G5A0">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283899.2">
        <property type="protein sequence ID" value="XP_028139700.1"/>
        <property type="gene ID" value="LOC114333899"/>
    </dbReference>
    <dbReference type="GeneID" id="114333899"/>
    <dbReference type="KEGG" id="dvv:114333899"/>
    <dbReference type="InParanoid" id="A0A6P7G5A0"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF74">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="6">
        <location>
            <begin position="187"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028139700.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="42828" checksum="51EB93266CA1A290" modified="2020-12-02" version="1">MSHRFSYPSLMGPNLDAKPSELPNPPNSDVALSEYDDGYNNGGLDVCSNEFAEVANRELINRELVNLENAVVNIDNSNDVIIGPVTQFNVNGNVTIFHNKDGQPVEIEEKSEISPPKYTDVSAKVQKEDEVAFSARKKCTLRIYLIGVLLVFLVSTTAVILVFVLRKDAQDQIPHKEDTIIITNSSSRLIPKEVWGGRKAVGKMEELKTPVGLVILKHTAGGNCSNFEQCAKKMQTLQSTDIGDNDLPDIYFNFGIGADGNAYFGRGWNILPASRANCIEIVLIGNFQIDPFTLTMFKATKALLKHGTDHKYLSEDYKLIGHNQVNTTKSPGKNVLAVINQFQHFDPTDYKGIPLDSDPMKQLSNNAAKFAPPSKSPAGKNEKLSEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8B7</accession>
    <name>A0A6P7G8B7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBC1 domain family member 22B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335110</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141078.1">
        <property type="nucleotide sequence ID" value="XM_028285277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8B7"/>
    <dbReference type="FunCoup" id="A0A6P7G8B7">
        <property type="interactions" value="1919"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285277.2">
        <property type="protein sequence ID" value="XP_028141078.1"/>
        <property type="gene ID" value="LOC114335110"/>
    </dbReference>
    <dbReference type="GeneID" id="114335110"/>
    <dbReference type="KEGG" id="dvv:114335110"/>
    <dbReference type="CTD" id="42498"/>
    <dbReference type="InParanoid" id="A0A6P7G8B7"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000004">
        <property type="entry name" value="TBC1 domain family, member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="161"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028141078.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="54384" checksum="E06997F56E6741AF" modified="2020-12-02" version="1">MESEHQEKSSFWKKNVKSVAGRPSPKRDVKDIRKTPGSTSFQDFQASVSDAWDLDDDEFCIISGLENTKISKKVAHSAALNVLNSHRSTTESEASTEKKHSKRMNISETESIKISRIPGRPKPIRRLPCEQEGVEKKLERFENILETSLTLQELCQLSWSGIPAKVRGITWRLLSGYLPMNIERRNEVLERKRHDYWSLVEKYYYTEHDETNRDIQHQINIDVPRMNPSIPLFQQKTVQIMFERILFIWSIRHPASGYVQGINDLVTPFYIVFLQEYLKEDQPFEKCFVDELTEDQRRVVEADSFWCLSKFLDSIQDNYVFAQIGIQKKVLQLEELIKRVDETLHKHLKEHNVSYLQFSFRWLNNLLTRELPLRCTIRLWDTYLAENDCFATFQLYVCAAFLLYWKDDLMQQHDFQGLLLLLQNLPTQSWTSSQISLMVAEAYKLKVMFADAPNHLLSNNSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAF5</accession>
    <name>A0A6P7GAF5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone H3-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114337537</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143807.1">
        <property type="nucleotide sequence ID" value="XM_028288006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288006.2">
        <property type="protein sequence ID" value="XP_028143807.1"/>
        <property type="gene ID" value="LOC114337537"/>
    </dbReference>
    <dbReference type="GeneID" id="114337537"/>
    <dbReference type="KEGG" id="dvv:114337537"/>
    <dbReference type="InParanoid" id="A0A6P7GAF5"/>
    <dbReference type="OrthoDB" id="420022at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028143807.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21250" checksum="5F611909CA3741C8" modified="2020-12-02" version="1">MVKRKIVPRKSAVSQSPSTSGSSRNTRTSTSTPKRTRDENEKIPSRSRNDADTPSKSTPNVSKNKRKSGKRKKVRQVTQMSLGRKYFKVSNAILRDIGRLQRAVTNCIPKLPFSRVIREILLEQGHTQQLRIQIEALTALQEAAEIYLINLFEDANRCAAHARRITVMPRDIQLTLELRGPNEVGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBM3</accession>
    <name>A0A6P7GBM3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetratricopeptide repeat protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335671</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141750.1">
        <property type="nucleotide sequence ID" value="XM_028285949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBM3"/>
    <dbReference type="FunCoup" id="A0A6P7GBM3">
        <property type="interactions" value="2253"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285949.2">
        <property type="protein sequence ID" value="XP_028141750.1"/>
        <property type="gene ID" value="LOC114335671"/>
    </dbReference>
    <dbReference type="GeneID" id="114335671"/>
    <dbReference type="KEGG" id="dvv:114335671"/>
    <dbReference type="InParanoid" id="A0A6P7GBM3"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028141750.1"/>
        </source>
    </evidence>
    <sequence length="787" mass="91363" checksum="C277DC7BEA092E2E" modified="2020-12-02" version="1">MADIEKALYDFLLVTRQKPKADEEKLQNGTDLEDLNIYLVSDDNWKIFFDRSFDVEQLKTHFSTLQENDRIDCLKFGISCILNFVQCNFTGPDLSKEIKDYLSKDTYDTLNFAKLLSVNNEDININTRYPALLVTSKIIFEHCAVDNMINNWWYWRSILVHQEILEELSPSLLSDADRLYKHFQINPDLSINIKSSLDIEVAQLYLLFRHISKAKEHILSAIELLGIHYDLMGALGKRTKFQEREIAQLSLKVTVTEKDIITRDRGIDDIDDSDVPMDVPINDDVRLNTIEFTEDLGNLAKLGSLEQKLFVTIIKDMLISKPPDELQVEEIMPFIDAILKQKNTFAVRVVTLLLRCKLESKTRRTIERALSQSEEIIKSLLREKPVALKRITDVFGTGMPPVWKIETQYADLLLNIGLVKNALDIYLKIKLWEEVIVCYTILKLRHKAAEVILDQLKEKPTVKLWCLLGDATDDITCYVKAWELSKRRSHRAQRHWGQFLFARKQYEECIPHFEKSVSINPLQSNVWFRLGYAALQTENWQTAATAYRRYTHLEPEAFEAWNNLAQAYIKIGNKRNAHQAILEALKCNFDNWKVWENLLVISCDISNFSDVIRAYHRLLDLKEKYLNVEVLNVLVYHVCHDINDCEGLSSQRYLQKTRELLGRVTALYPNEGYVWELYANLAPAIMLKAQRLQRAYRGYTQGAWDKNPTTCQQMLYVCIKLADIVLDNEVDPKDTLINSIKLNLSSAITAIKKQDWEETRDLVEQVSVHLEKIIDKIKGYHQDKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GG66</accession>
    <name>A0A6P7GG66_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tudor and KH domain-containing protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114342113</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148701.1">
        <property type="nucleotide sequence ID" value="XM_028292900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GG66"/>
    <dbReference type="FunCoup" id="A0A6P7GG66">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292900.2">
        <property type="protein sequence ID" value="XP_028148701.1"/>
        <property type="gene ID" value="LOC114342113"/>
    </dbReference>
    <dbReference type="GeneID" id="114342113"/>
    <dbReference type="KEGG" id="dvv:114342113"/>
    <dbReference type="CTD" id="33401"/>
    <dbReference type="InParanoid" id="A0A6P7GG66"/>
    <dbReference type="OrthoDB" id="9995375at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="287"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028148701.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52085" checksum="9C4C79C54A3B4125" modified="2020-12-02" version="1">MGVVTKSLTVVLGLTACGLSGYFLYLLLRKDDDDDYTDTYAKASKFKTYEIKVPKDIVSSLIGRNGNNIKKIQEQSSTRINFREVQGSEDRICIIRGSVEACHIAENLIQDFITNQPILESQDMWIPFASVGKVIGRNGDKIREIQSLSGAKVTVTDDDKALNTKRVTMKGTKEQINVAKSLVEDVVEQVLEQQQRLEASLAKREPRLPPKSPDSNNRIESPRGERMSPIPGQPEAPFEVYISAMVDPSRFWLQIVGPKATELDCLVEEMTEYYGKIENRNMHVLDEVKQGDLVAATFMYDSKWYRAEVLKITENPNAGKQAELFYLDYGDTDVLPCKELFELRTDFLRLHFQAIECFLARVEPNGESWSVEAVDRFEEWTHVAQWKKLSAKMNGYSAREKTRAKREGSPVPGVDLYEIEEHDIDIAEELVKAGFAVFKKDANLLSSSRATSNSNISVASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJL3</accession>
    <name>A0A6P7GJL3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BET1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Golgi vesicular membrane-trafficking protein p18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114343234</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with SNARE complex members GOSR2, SEC22B and STX5. Interacts with LMAN1/ERGIC53. Interacts with STX17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the BET1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149839.1">
        <property type="nucleotide sequence ID" value="XM_028294038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJL3"/>
    <dbReference type="FunCoup" id="A0A6P7GJL3">
        <property type="interactions" value="1320"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648923.1">
        <property type="protein sequence ID" value="XP_050504880.1"/>
        <property type="gene ID" value="LOC126883392"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GJL3"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000026">
        <property type="entry name" value="BET1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="21">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028149839.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12796" checksum="72FE452A40B26E0E" modified="2020-12-02" version="1">MRRAHAGNYYEPLPQASNEIEDENDRMTNDLQEKIGVLKSLTIDIGNEVKYQDRMLRDVDDDLDKTGGFLGTTMSRVLRLSKGSHNYLILYLFVFSVVVFFILYLVIKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJY5</accession>
    <name>A0A6P7GJY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114343345</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149964.1">
        <property type="nucleotide sequence ID" value="XM_028294163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJY5"/>
    <dbReference type="FunCoup" id="A0A6P7GJY5">
        <property type="interactions" value="1317"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663152.1">
        <property type="protein sequence ID" value="XP_050519109.1"/>
        <property type="gene ID" value="LOC126893196"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GJY5"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="242"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="11">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028149964.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="77567" checksum="E85ED434E5F66003" modified="2020-12-02" version="1">MADSNTSKSDCSFFQKYCEHAIGQLSENELEEFRQTKDENSRIQLLYEAATNIPITLNELNGKNYELSQSEKSKGNTYFAKKDYYNALKCYNDGIIKCPQNSGEAQELLSILISNRSATYFELKEYRQVLNDIDYLLEIGRYPLHLTYKIWIRKAKCYSALQNEKLAAESYDEAIKSLQFSNLDKETIETHEKKIATARATKIEYFPKQELVVQENPEIFQGGKEYIAASTNVKFEQDPDLGRYAVASDNIKTGSIIVEENAHCAVVDAKHALTNCQNCVSAVVQLVACPTCANVVFCSTTCERLANKSFHKTECPILGSLYLSGASINCCLALRIISQRYFSYFNDKRNKLKDYLIDNNEKNIIKKKIYRYDDYDNVFFLCRNDHLRKIEEMLRFSYMAIYLLRLLKFGKYFPFETSDGVLKEEEVYFGSLILRHLQLLQFNAHEVSELKNVEKPISTKGIADVREYENTTIGAALYPTLALFNHSCDPSIIRYNVKSKIVVRTIKPIKAGDIIYENYGPLYMSMQIKERQEALERLYRFKCLCTPCTQLWPTFAEMKEHELRIPCKTEGCPFVFNLKGDGEPFFTCNYCHSTHCVLPNLKGLMMLEELLPEAENFYTTGNLKSALNKFIQALEVLYKHTSPPHPEIIKIQQRMRNCIIHMGNKACGYKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKD6</accession>
    <name>A0A6P7GKD6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cullin-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114343472</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15 16">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150109.1">
        <property type="nucleotide sequence ID" value="XM_028294308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519436.1">
        <property type="nucleotide sequence ID" value="XM_050663479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKD6"/>
    <dbReference type="FunCoup" id="A0A6P7GKD6">
        <property type="interactions" value="2307"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663479.1">
        <property type="protein sequence ID" value="XP_050519436.1"/>
        <property type="gene ID" value="LOC114343472"/>
    </dbReference>
    <dbReference type="GeneID" id="114343472"/>
    <dbReference type="KEGG" id="dvv:114343472"/>
    <dbReference type="InParanoid" id="A0A6P7GKD6"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000001">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000004">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000008">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000059">
        <property type="entry name" value="Cullin-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="17">
        <location>
            <begin position="396"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028150109.1"/>
        </source>
    </evidence>
    <sequence length="752" mass="87425" checksum="E329690CEBFD9ACB" modified="2020-12-02" version="1">MSQNTNNSVGRPNFSNVPNRSINLINIKATTKKLIIKNLKSEPRLPPHYMEDTWDKLKSAVIAIQNATGNQYALEELYQAVANMCNHKMAPIVYDRLYDLVEVHVAQNIEQFLAESMDRLLFLKKMNDTWSAYCNQMKMIRSIFLHLDRTYVLQNSSQLMSIWDMGLETFSKYILLNTLVQTRVVEGLLMLIEKERQGDQVDRTLLKSLLRMLTDLQIYDKAFEQKFLQATERLFAAEGQRLIQLLDIPDYLNHVDKRIKEERDRVIHYLNDTTEKQLIHTVEKQLISEHISQILQKGLRQLMNENRISDLTLLYTLLARVKNGTTELCTAFNGYIKTRGKTIVIDPEKDKSMVQELLDFKDAMDNVVSTCFAKNEKFTNSLKEAFEHFVNQRTNKPAELIAKFVDYKLRAGNKEATEEELEKLLDKIMVIFRFIQGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKQECGGGFTSKLEGMFKDMELSKDINVAFKQHLSVNSRNLAPIDMSVSILTMGYWPSYQAMEVSLPYHMVKFQDVFKDFYLSKHSGRKLQFQPTLGHCVLKASFKGGKKELVVSLFQTVVILLFNDYDELSLEDIRAATNIEDGELRRTLQSLACGKARVLNKIPKGRDIEDSDKFRFNNDFTNKLYRIKINQIQMKETSEEQKATEERVYQDRQYQIDAAIVRIMKMRKTLSHNLLISELYLQLKFPVKPADLKKRIESLIDRDYMERDKDNPNQYNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GME0</accession>
    <name>A0A6P7GME0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inter-alpha-trypsin inhibitor heavy chain H4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114339869</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146353.1">
        <property type="nucleotide sequence ID" value="XM_028290552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GME0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646787.1">
        <property type="protein sequence ID" value="XP_050502744.1"/>
        <property type="gene ID" value="LOC126882017"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646788.1">
        <property type="protein sequence ID" value="XP_050502745.1"/>
        <property type="gene ID" value="LOC126882017"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GME0"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028430970" evidence="1">
        <location>
            <begin position="20"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="299"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028146353.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="87590" checksum="B3D41EE1F5FA733B" modified="2020-12-02" version="1">MKTILVGCVIFLSVGFTICAPNLVLTTDPPKTHNETKEGTEKPPDLIIYEFGVKSNISNRYSTTVITSRVKNPDANSKEAVFSVVLPEKAYISEFVMEIKGKKYKAYVKEKEEAKNIYDKAVQSGQSAGYVAVSARDSNRFTVSVNVEAETKAVFYLTYEELLERKNNKYELVLNIHPGQIVKDLHVEVIVNETRPLKFVKTPSLRSGNEISKNDETLDPGSVVNIINSTSAIVTFKPDIEQQKNFIKTLGGKENEGLTGQFVVQYDVERDPSGGEVLLHDGYFVHFFAPENIKPLTEHIVFILDTSGSMYGTKLKQLKDAMASILSQLKEDDTFHIIEFNTYVYVWDINNKEKIKVNITDDDKPFEDVVKAVLPPAIQATKENIVKGKEVIEKLQDEGITNMLSSLITGLHLAKSTYKNESEKTHHQPIVIFLTDGDPTAGIINTDEITNITTDYNSGDIKVPLFSLSFGDEADKYFLRKLSLNNLGFSRHIYEAADASLQLQEFYNEISSPLLANVHFKYDSEVKAVSRKDFPIFFRGSELVTVGKYEGTFSGTVEGSGINGTISVPTKVETPVSSLERLWAYLTVKQKLEDRETVANKTQLTKDALDLALKYSFVTDVSSLVVVKPNDTSSVNTVDASNSGGDTSRASVVGLRFTYDDMDYDDGGYMGSFESFSTSIPQALTNDINDDDPMDIFTDLPWLNGTLTANKTLTVSGRSYEIESIKVIPPVDCPVTPLNNNKTGDCVLLMECPGVFAFLPTFKDYQKYFCSLDNNKYAGVCCPKLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNB1</accession>
    <name>A0A6P7GNB1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114344757 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114344757</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151386.1">
        <property type="nucleotide sequence ID" value="XM_028295585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNB1"/>
    <dbReference type="FunCoup" id="A0A6P7GNB1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642355.1">
        <property type="protein sequence ID" value="XP_050498312.1"/>
        <property type="gene ID" value="LOC126879277"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNB1"/>
    <dbReference type="OrthoDB" id="6781148at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028310162" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028151386.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10203" checksum="B55AA41CE7F00213" modified="2020-12-02" version="1">MKFVIFCTIFFITFGLGELLIPKCPENSHQGCRPCCPNPSCRFRNPTCPKDRVCTFDCKFACICDKGYIWDDIGIVGGCIRPKDCPPIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPI3</accession>
    <name>A0A6P7GPI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
            <ecNumber evidence="13">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114341361</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="13">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EC" id="3.1.3.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028147952.1">
        <property type="nucleotide sequence ID" value="XM_028292151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPI3"/>
    <dbReference type="FunCoup" id="A0A6P7GPI3">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658768.1">
        <property type="protein sequence ID" value="XP_050514725.1"/>
        <property type="gene ID" value="LOC126889979"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GPI3"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051998">
        <property type="term" value="F:protein carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000002">
        <property type="entry name" value="Acidic residue methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="14">
        <location>
            <begin position="39"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028147952.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51632" checksum="E4A6F48B9427B5AC" modified="2020-12-02" version="1">MSDNLPVTCDCGSSGSLDLKTPRNVYLSAFYKRSFAFYTVAHRMPVILTNLIDNLVRHKSEIKEKYGNEALDELKAIIGEISEFKYEVQTNKPLKLLIGDAPDVNIYNEYIKKQSVAEGHTTHFHTIWLLTECYMYRRIKQIFETKLHLKDYDYFEQQKQDSYTGAIKLIENMSEHVVHVLNNQNPADQNEFINMLKLNLWGNKCDLSLSLGKASDHSSLFDTAALDPYILCDHSKQIWEGISTDKSSDYIDIVFDNSGYEVFTDLCVADYIITKGLAKSMRLYVKTIPWFISDVMEQDFHWTLKQLMSSENVNLQVLGQRWSKYVEDGIWTIVASNFWTLPYDYTYMADLDPQLYKKLGEAKAVFFKGDLNYRKLFGEKNWDPATPVDIGLQSFHPSKLCIIRTIKADIVAGIPDGVAEEIEEKDPKWMHNGEYGVIQFSKNKVAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPL9</accession>
    <name>A0A6P7GPL9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial assembly of ribosomal large subunit protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114339290</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145715.1">
        <property type="nucleotide sequence ID" value="XM_028289914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPL9"/>
    <dbReference type="FunCoup" id="A0A6P7GPL9">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289914.2">
        <property type="protein sequence ID" value="XP_028145715.1"/>
        <property type="gene ID" value="LOC114339290"/>
    </dbReference>
    <dbReference type="GeneID" id="114339290"/>
    <dbReference type="KEGG" id="dvv:114339290"/>
    <dbReference type="CTD" id="136040730"/>
    <dbReference type="InParanoid" id="A0A6P7GPL9"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000018">
        <property type="entry name" value="Mitochondrial assembly of ribosomal large subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="IOJAP SUPERFAMILY ORTHOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043:SF0">
        <property type="entry name" value="MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028145715.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27866" checksum="3C9760B178DEDA1A" modified="2020-12-02" version="1">MISNFRYILAISKPKFVKIYRPLVSTVRFKSNQDASNADKKTTTKPKAVLGNMSSKYDVFSDADAEIILDVYEEKLKYSQLLEEEEQEVDRYVGLNLERGKTGVYDIEDLVEVLKREQAQNIFVVSVPKEINYVDYICIVNGKSVRHMQAIAQFIKKVFKQKRRESDLLPKVEGEDSRDWLALDLGNIALHIFSEKARAHYNLESLWALGHEFDDEYNRPEPVSDILEKHSVYLKDLQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQY5</accession>
    <name>A0A6P7GQY5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hippocampus abundant transcript 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114345360</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028151984.1">
        <property type="nucleotide sequence ID" value="XM_028296183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQY5"/>
    <dbReference type="FunCoup" id="A0A6P7GQY5">
        <property type="interactions" value="1308"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656520.1">
        <property type="protein sequence ID" value="XP_050512477.1"/>
        <property type="gene ID" value="LOC126888350"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQY5"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028151984.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="53079" checksum="E593FA7F96FCD00D" modified="2020-12-02" version="1">MDSNVEEGEKMKAKSSKRMVGMIIRSRKSIAKDAVVTTSGIGQPSLYHALVVIFLEFFAWGLLTMPLISVLNDTFPDHTFLMNGLIMGIKGILSFLSAPLVGALSDVCGRKLFLLITVFFTCIPIPLMTINTFWFFAMVSISGVFAVTFSVVFAYVADVTDERERSLAYGLVSGTFAASMVISPALGAYLMERWSVSLVVALATAVAILDVFFILVAVPESLPEKVRVSPISWEQADPFASLRNVGQDPTILLLCIAVFLSYLPEAGQYSCIFMYLKLVMGWSDPMVAVFVGLVGLMAVIAQLSLGILIKNLGSKHTIMLGLLFEMLQLLWYGFGTTTWMMWGAGILASMSSITYPAISAFVSVLSTPDRQGVVQGMVTGMRGLCNGLGPAMFGVVFSMFHVDLNGNNNNADATHSTSSFETYSQLVPGPPFVFGAFLVICALFVASFITSKSHVDSGIPLDTHYEIERGQKVAGTLSPLIPSRSIDAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GS17</accession>
    <name>A0A6P7GS17_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114342258</name>
        <name evidence="8" type="synonym">MED4</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148847.1">
        <property type="nucleotide sequence ID" value="XM_028293046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GS17"/>
    <dbReference type="FunCoup" id="A0A6P7GS17">
        <property type="interactions" value="2172"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651060.1">
        <property type="protein sequence ID" value="XP_050507017.1"/>
        <property type="gene ID" value="LOC126884814"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GS17"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028148847.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27932" checksum="F422566525FDAF26" modified="2020-12-02" version="1">MSQISTKEKLLYIIDDMELIAKEIIENAIAPKSAKLSGPEYAQLTDLLVAKDNELKSTLQQASEQAQLNKKLDTLKAEVERQDQDINNLQKQLKEAEQILSTAIYQANQKLQSIARAKKKPVSSEELIKFAHRISASNAICAPLTWQQGDPRRPYPTDIEMRLGLLGRLGDPMNGHLLSQQNNMSDLHRPGHPGEIPAAQQNQFAWHPTGEMHISVGQGTVPMDTRNHKQENEDVEVMSTDSSSSSSSDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTA8</accession>
    <name>A0A6P7GTA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114340505</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028147055.1">
        <property type="nucleotide sequence ID" value="XM_028291254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTA8"/>
    <dbReference type="FunCoup" id="A0A6P7GTA8">
        <property type="interactions" value="708"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291254.2">
        <property type="protein sequence ID" value="XP_028147055.1"/>
        <property type="gene ID" value="LOC114340505"/>
    </dbReference>
    <dbReference type="GeneID" id="114340505"/>
    <dbReference type="KEGG" id="dvv:114340505"/>
    <dbReference type="CTD" id="4478"/>
    <dbReference type="InParanoid" id="A0A6P7GTA8"/>
    <dbReference type="OrthoDB" id="8957712at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000003">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000006">
        <property type="entry name" value="TRAF2 and NCK-interacting protein kinase isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051700">
        <property type="entry name" value="STE20_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47096:SF1">
        <property type="entry name" value="MISSHAPEN LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="13">
        <location>
            <begin position="955"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="840"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
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        </source>
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            <dbReference type="EnsemblMetazoa" id="XP_028147055.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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    </evidence>
    <sequence length="1271" mass="142475" checksum="B1DDD50B5044880A" modified="2020-12-02" version="1">MAHQMPPSVNCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLSYLHTNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCELHPMRALFLIPRNPPPRLKSKKWNKKFHGFIETVLVKDYHERPYTEQLLKHSFIRDQPTERQVRIQLKDHIDRCKKRKQEKEREDYRYSGSENEEEEPQVAGEPSSIIQAPGGDTLRRNFQQIQEGRTLSQVEPPPRGGKNKDREEIPEPGPPARPPIPQRMIVVPDPAPPRRPLPPPPDNNFGAPKSQNQQQQRNSQHQFKPMQGPARKPEELDALAAHLNELGVQQTNQPEAPPRNRNYKQSQSASNNNVTTPSSAVNHTPTNQGGNNIDSLVDSETDSEPEDNGRVRNDGTLLASDPPKPLPEFSYRAGLGVVPEGTASVSSPGATAGSGSSSSSAPNRPLPPTPDDDESQGDRTLVLRKQSAANIGEKKKKAEDIDEATLLKDWDFDKFFPTKLPNTASSSSSTSNSSGNKKEDKNKGHRRMESDSKVSNPFLRGFRRENSDFFPLSSRHSAIYIDKNARSSGIFNNRRGSDVGISKKTTGEPVLMDYVKKTDSLITSTPKKDNNHNFSEKPEIVSFVRPRREKTESDLVLRHSEARRSIRETLEARRREVEAQFAKEAESMRRRSSKPIEMNALNISNISSSSAGSNVTVGDEFSFIQNGRSNDHPRQSVLPDLLSQASGSPGTPSTRDKSSNEEFHITPPSSIKKPSPQTSHLHANALALQQKQRSFLAFGFGASSAPSRRESHVNVNVTPTSHDMLSDTPEIRKYKKRFNSEILCAALWGVNLLIGTEHGLMLLDRSGQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSKILRTDGASDQVERRNGWINVGDLQGAVHFKIVKYERIKFLVIALKDSIEIYAWAPKPYHKFMAFKSFCDLQYRPLLVDLTVEEGTRLKVIYGSSDGFHAVDLDSASVYDIYLPKIAQNGICPHCIVTLPNSNGMQLLLCYDNEGVYVNTYGRIAKNMLLQWGEMPTSVAYIGTGQIMGWGNKAIEIRSVESGHLDGVFMHKKSQRLKFLCERNDKVFFSSAKSGSSCQIYFMTLNKPGMANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTB5</accession>
    <name>A0A6P7GTB5_DIAVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="6" type="primary">LOC114342661</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="6">Whole insect</tissue>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="LOC126884687"/>
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    <dbReference type="OrthoDB" id="112668at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DS_RBD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="279"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028149272.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62545" checksum="B98AC484B7C4224C" modified="2020-12-02" version="1">MNGSVEASQDSSSCPFFGKNLQNGNAELNKFHILDETEGNDDTDNSADFDSDIPDDEIEKMLEEALEKRKRKAADAGLDDEEIPFEEKNKILLIEKGQNHFDVLPEGWIQVTHNSGMPIYLQKVSRVCSLSRPYFLGPGSARKHHIPVNAIPCLNYRKALEKEESESNEPETNNHCDQSFPNAKIETVQENLQMQNLPPEQVREYCEKLFKFQTMKVLRFKSWSERRKFTKRLKQKKQLQRLTLPDGTKLITFPIRKSDSSENNTNSKKEWVMNPNGKSYVCILHEYVQHVLKKQPTYQFTELENAATPYAATVIIKDMRYGVGYGTSKKQAKSDAAKATLEILIPEMKSKIVPDNQTGDSTKKDKDQDLSFFDEIRVEDPRVFEFCAKTTEPAPYDILLTCLQRNFGLDDLQISYQGNTSKSHEFTMTVGKHTATVSCKNKRDGKQRASQAILQALHPSITSWGSLLRLYGNHSIKSFKEKKLEEQEITSLQSKAAVNQPNYAILSKLNIELGKLREKRKAIQPIGVLDTDGTEVVAPFSSTSNLHNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GU11</accession>
    <name>A0A6P7GU11_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114340755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340755</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147325.1">
        <property type="nucleotide sequence ID" value="XM_028291524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GU11"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645246.1">
        <property type="protein sequence ID" value="XP_050501203.1"/>
        <property type="gene ID" value="LOC126881167"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GU11"/>
    <dbReference type="OrthoDB" id="424490at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147325.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="35737" checksum="819B3F9DD145F7EA" modified="2020-12-02" version="1">MEAMEVSSIFDIINITQRNDAELMQYLQSVGLIKKQFKCKIRNCRRICTVRRKEGSYRLNHCFWCFKCRKMYPITIGTFFERIRVPVRTLFYIMWCWACQLPVKNTTELISLQKGSVVNMYAHLRNILSWKLLQEEPFLLGGEGHTVQIDANIMGKRKYNGGRVIKEHWVLGIYDLGLKRGHVTYLKNRNRDKLVEIIQKHVQEGTEIWTNQSQGYSNLNHLGYIHKTVNNSKYFKNPQTGFCSNQVGGYLSRLKKYLRRLGVISSPFLPQYIEQFEWDSLYGHNARDRFKSIVEDIRQKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1D0</accession>
    <name>A0A6P7H1D0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FAM91A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114343227</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149865.1">
        <property type="nucleotide sequence ID" value="XM_028294064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1D0"/>
    <dbReference type="FunCoup" id="A0A6P7H1D0">
        <property type="interactions" value="2118"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294064.2">
        <property type="protein sequence ID" value="XP_028149865.1"/>
        <property type="gene ID" value="LOC114343227"/>
    </dbReference>
    <dbReference type="GeneID" id="114343227"/>
    <dbReference type="KEGG" id="dvv:114343227"/>
    <dbReference type="InParanoid" id="A0A6P7H1D0"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="799"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028149865.1"/>
        </source>
    </evidence>
    <sequence length="921" mass="104336" checksum="012050B333B9C3C0" modified="2020-12-02" version="1">MNAEIEENIRNKVPWSQLPSHIKQILSNSSKEYDRCVVNFSIKNQLRYRGNLVRYIFRDEKRYYERIVSYSRERLMLFPYHLADMIVKGLRITPFNYYISVVEKLMQAEKSYDTLPNFTAADCLRLLGIGRNEYIDLMNKSRSNKGRLFGRKNVRGLLPTVPCDIYMQPWWRVEVGLVLEEDVKMVNDEELHIIDKLIDLGSQNAGDLPYYIVLSLYKKGLIYLDVPITAADMVQVPPLQGFVMNRILGDYFETLLYKIFVSIDEHTTVGELAAVLQVDTELVKQAVSLYCRLKFAHKLNLDPEQEKQWHSTWLNIPTQDSNNMDITPLTLSLSKDSALNTSSDFQSPQSDLPESPASSSLPRRGQRVAFLFDSTLTAYLMMGNLSPGLKKHAVTMFEVGKLCDESLDSFLAELEKVSVLDAEGEGEARRFFDHAVILRSTVMALRKLPSPGLDLVRLESLHSLDEATCLRLLQKKYKLLVSMAPLSREVRPVTSLLPPHLGPAVPEVNTLWFKLFLYHLTGYGPPSLLLTKGTTLNQLPRMFLGFSRLLIHSWLHEPAVIPIANILYVNATLQFSPVLIQAYGVHQPAQTHIISFPFQPLTPIKSNEKKIKERPTDLAFRQHKAVKYLQEVVDLDHNCGYLTFANIGVLDFGCPNREKQVRLGRNNRTAGSGFSKLSRIKTENNNQLNQPLSISNENFAFNTEKPQEKPEKETKLQSPVESHFAVTPVSNTSQSSSPANGFTSQEGSNLLQEELDQLVVSQEGTNKENITLELSLKNSLSIDGLTSPNEENISMFSRDNKEENVKSESDCEQKKDDSGEEQNIAEAWTLLDCHFGIPLFDVNANTKICDNIVYGGLAEPSSLEHLVESSRKLGSALLDFISQCQYYPGENMEILKRGRLVPLPRHNLAFDNGRVSEWLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H410</accession>
    <name>A0A6P7H410_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114346708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114346708</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028153262.1">
        <property type="nucleotide sequence ID" value="XM_028297461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H410"/>
    <dbReference type="EnsemblMetazoa" id="XM_050661899.1">
        <property type="protein sequence ID" value="XP_050517856.1"/>
        <property type="gene ID" value="LOC126892374"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H410"/>
    <dbReference type="OrthoDB" id="6683043at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028153262.1"/>
        </source>
    </evidence>
    <sequence length="57" mass="6665" checksum="7370A7EE15A2D38E" modified="2020-12-02" version="1">MFHMYWPATCAITLFLIVGVIMVMLKWGPRLCKLRHTALPDRGTWQHATYEQPISYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H4V2</accession>
    <name>A0A6P7H4V2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114346115</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152703.1">
        <property type="nucleotide sequence ID" value="XM_028296902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H4V2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649726.1">
        <property type="protein sequence ID" value="XP_050505683.1"/>
        <property type="gene ID" value="LOC126883958"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H4V2"/>
    <dbReference type="OrthoDB" id="6739670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028152703.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43141" checksum="72805CA74B0295C8" modified="2020-12-02" version="1">MDGEFSFMDFDLLTVASNGCFSVLNLALDNIDIYDFIVDTQDSDGNSLLHHVAAAGNLETLEKLISLSAYANILNHKRETPLHVACLNGHHSMVTRLLKYGAKLNVLDIERETPLFKSVRGGNKALTKYLITQKAVVNTSNRAKEKLIHLATAYNDMNLVEVLIDIGQDPNILTGSGEAPVQIAIKHSRLEILKLLLERSATKSIRDHRNYTLVHLAVEAKFKSICQMLLATGHEVNVRDHNGYTPLHLAVELNSVEMVELLLEYQADINLLDVDGYTPLHIAARGETSGDIINMLLKNNANTKIKTEHGDVPLHIAAGVGNIRSYIKLYNKQDNTIVNVIGLTPDRLAQIQGHTVINQLNIELNNNNKSYVPKIPIYKQLRKLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6S1</accession>
    <name>A0A6P7H6S1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Facilitated trehalose transporter Tret1-2 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114345023</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151645.1">
        <property type="nucleotide sequence ID" value="XM_028295844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6S1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050643161.1">
        <property type="protein sequence ID" value="XP_050499118.1"/>
        <property type="gene ID" value="LOC126879853"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643162.1">
        <property type="protein sequence ID" value="XP_050499119.1"/>
        <property type="gene ID" value="LOC126879853"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643163.1">
        <property type="protein sequence ID" value="XP_050499120.1"/>
        <property type="gene ID" value="LOC126879853"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643164.1">
        <property type="protein sequence ID" value="XP_050499121.1"/>
        <property type="gene ID" value="LOC126879853"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028151645.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50703" checksum="80DCB90F1B3020DB" modified="2020-12-02" version="1">MGIKEKINYAYLVAFCGNLLALTGDTTLTWSSPILTKLDSNDTDINPLGRKITLDEISWIGSLQYIGAMVGILPFAVLADVIGRKPVLLLLAVPHIISFLSFAFAKTIGWYYVGRFLGGVSLSSVYIILPMYVAEIAEDSYRGMLLMSYSTFASLGDLIPYVLGPYVSVLWFNIILAVFPISFLVIFLIIAPESPYYYVNKEDEKAEKILKKLRKTKSKYTATNEIEEIKREKARNVQGDIFNTLKKKYVIKGFLVALGLSSFQQLSGLGAILAYTEIIFGFAGTGLSNEVSAMIVGVVLFLASFAGPLIVDRKGRKFLLTVSALGCIISEIILGAYFYLHEHSDVSLKNWSWVPIACLIIYVVTFNIGFGPLPFTITSEVLPSNVKFYLATVTGFTGWLMSFLVTKFFNDLNLALGIGGTFWLFACFCIAALVFVIFFVPETKGKSFQEIQIFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I969</accession>
    <name>A0ABM5I969_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nipped-B protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127812.2">
        <property type="nucleotide sequence ID" value="XM_028272011.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272011.2">
        <property type="protein sequence ID" value="XP_028127812.2"/>
        <property type="gene ID" value="LOC114324227"/>
    </dbReference>
    <dbReference type="GeneID" id="114324227"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127812.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1546" mass="177188" checksum="49A6A051EB903815" modified="2025-10-08" version="1">MPSADDKQFTQVIRKILRPGTTRSSQDKYNGIDKKKEIEFKTPSAPRQQTTGTKRTAKESMILLENGSGKFPALAGIKKQRKSDIAKTELDTKKKIEKLDIFSSLQQIKEQNLKLQPKKQMINSNVCESFRKHIDCVVSKCESNGTADIDNQILMTLYQEAAGLNHIGNTNKINVEKLVKLLNLLEANIKVGTKISPLSNKDLQLFRLSIERVLATADACLICMYIMTSKNMPKRVYLEEVIHRIMQYINHNITNTILPAVDPTYSAENKTKKNNQDSKLISEKCLILLGVKITELVYLIAELIDFLTLDETAIFLAFSIGAATFWAKNVQNLQIASMNLVTKLFRTYKRHQTVFLDNILSSLMLLPTTKQHLKTYILKDGKNISIVSALVVQLIQSMVTLPENLFQKNTKTKTKTKDKVDIDSLICTKYKEATAMAAGFLTIFFHRCFKMQKNSDRRSLFENFVDDLLLVRNNPEFPGTDLVLCLLGKMLVKLFLNKNEQVALRVVSLDCLSIIAGKLRKDNVLFASEKANIDDMISTIKRREQKGNQKDVGNREIEVDILRNDDKFLQSLLLEFLGVNGRQNGIYKNARLFYLVQWHKDLATRKSQLVLDHKEESGNKKRNYKSKSSSKTKSKSKDKENVPEKDPEIMRIAEMEKFLLEKIQEVLSPEFEHQAYECQLDYNSAKMVVALLASKRYFSQSFDQYFNAILIVLKDASNVLRTKGLKCLSTIIKTDPTVLEGNDTQLMISQSFVDPSSSVREAVIDLLAKFILDKPELITKYYEMISARILDTGISIRKRVIKILNDICLDYPDFEKNTEICVKIIRRINDEESVKELVLKMFQNMWFTCASGSKLFKKVTSIIDIVIASKETGLENFEQILVELLEPTKDKYNSSKSKTDHPNEILRASRQIVDFLMEPTLRNPNQHNNESSERLAAVLKTLHIFAKIKPKLLVRHVSKFHRYLELQETSANDNGIIGSVIAILELVVPLSENPSEVFLAQLEEQIMKLLLRYDRTIVNSCLSCLAAICNKITHKYETIRDCFNKFYNYLLGYKTWEGVGMPTEEYAICKAVIKRSLLIVGLLLKYFDFKDPEVSGELAPDTTDQVYQTMLCFLQKDSIDIQVNTLKAIGILCSRYYQFLWENQLKTFYYKQLASKDTSLLMKAEILNNIENFLKEEDIRLTEDNKNWNKISKQTDLKEMDDTSSGIASLVIQYYLKVILNCYLYDSLQIRQAVYRVVQMILRQGLVHPLLMVPYLFCMSTDCEQPVALSAHKRLCEIESRYPGLIHTRSSLGIQLSFQLQKILQGEKVVRGFKVKEKEEYPVALNGGLYSLLRGSREQRRALIIYCLKQFEEPTELALSYMIYLADNMAYFPYQVQDEPLFLVHYIDIKISVFGTNLLQNFKDGLISAKNQPKNKNLADKKGDLTAIDTDEEEEDEQTLLNRLPKDTSQLQACISAAQGWLLLLSLKQYIVDIYGLSSENIQLYSPSVAAKVYEKPVQRKSNIMFNPKSTLEKLQEICLGKKQKAKNKTTLVREYIDFNKLVNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9L5</accession>
    <name>A0ABM5I9L5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">T-cell activation inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128064.2">
        <property type="nucleotide sequence ID" value="XM_028272263.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272263.2">
        <property type="protein sequence ID" value="XP_028128064.2"/>
        <property type="gene ID" value="LOC114324424"/>
    </dbReference>
    <dbReference type="GeneID" id="114324424"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="2">
        <location>
            <begin position="178"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128064.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="56378" checksum="ED3ECF30B440B0A2" modified="2025-10-08" version="1">MLRNFSSLLTNRPIILHNRNFTSIEVSTALRPFYFAVHPDLFGKYPSERATNESSLQQLSSILEKIQKSKSVPPVSLSFYVKDKAKKTDKFRFINIDIQGNDIRTTLCTILKSCDLPTDYVDSIIPPPPPSADNNPNSPNFKFRYKNEIDLTKVNQNHPIYAHIKMQMDMKRAQELLRLRNYLKKYAPEALKKSRKGDIHREEVKRLQEIITNELQVEELRWDCSWNEEHRKGCLLSFMSLVNQHASIKDVLRGRVLIFSSFFTGVSLDGHIMLYSGEVRHNWLDFLKNIDRYDAALKRIPAFEKSLSHVLRKIKIGRRKFMPKIVAGQYENNLRQITTSLSDYIGLKPFPVEWPSSLENFEIVVETEAGPLMVSPTGQFIVPATIPGSLLVNFITTNLEEASKKIVDYKSNKYLERALNKKCIEDLQLAVLSKDDNITPDLMIKCCEQLIKNKYELQSYTKDLRLNITTYYSVLSDGVVCIPWNFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9N9</accession>
    <name>A0ABM5I9N9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arrestin domain-containing protein 3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128098.2">
        <property type="nucleotide sequence ID" value="XM_028272297.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272297.2">
        <property type="protein sequence ID" value="XP_028128098.2"/>
        <property type="gene ID" value="LOC114324441"/>
    </dbReference>
    <dbReference type="GeneID" id="114324441"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="5">
        <location>
            <begin position="162"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128098.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40434" checksum="F30B0370F88F5D14" modified="2025-10-08" version="1">MTCKIVIINPGIFRPGDAITGKIICIFEREERIRGIKCQFRGREKVHWNERRGKHTTHYHGQTDFVVANTDFMDEGTMRPGKYEYNFSYVLPPSDIPSSYQHQFGSIRYFLHAYVDRPFAFDYKDDVALHVVSPIINHPTHQMRAVSLEVNKEVGTCCWPKEPSTMELRLERDNYVLGDVIYFKAIIRNTSDSEINSIAVQLSTTVQLTAYSPSTRHKTERILLAVAEGSGVAPGSTKIHKFSLKIPETAIITNFTRCTLFKQWCSLRVQALYPLFHSNMVAEVTIKLGDTIVRTEQIEHAVNSPSNSFVPVAEAPPVVYPPVPPSAPLANDRLAFIDDNNGTAEGPPPSYDDVVKGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAP0</accession>
    <name>A0ABM5IAP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128677.2">
        <property type="nucleotide sequence ID" value="XM_028272876.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272876.2">
        <property type="protein sequence ID" value="XP_028128677.2"/>
        <property type="gene ID" value="LOC114324921"/>
    </dbReference>
    <dbReference type="GeneID" id="114324921"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="230"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128677.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="516" mass="59101" checksum="C2251E55C2D9BBEC" modified="2025-10-08" version="1">MESSTPTRRTPRTKKPSLKALESLYSLKIQNSGIVQAIVTSDDESEDEIDLDNIDVDVNKPKVMHENEVVHGEDIFTFQKRKNSEAIAQKVAEACDLKTPKHVRTKTKSRIAKMIQEDSESEFEVSSEESESSSSSNESEDSSGSDSDEKSTKDTKNKKMIFREANLQTTKTRSRNYHIKTDEYFEKTSSKKIETSNNTLERLETPRLPQYKLQKLLHTVSHSSQHIEAIHKLKKVNESCFAKWWFFLNENFNILLYGLGSKRSIINKFQSLYLNNHPVVVVNGYFPSISIKSILDTILDLLEIEDIPGNPIEACDLIISEFQNMRGSSLYIIIHNIEGETLRNGKTQNILAKLASSKNIHFIASIDHINAPLIWDQNKLSKFNYIWWDVTSFLRYEEETSFEQSMMVQQSSTLALSSLRNVFASLTSNSKSIYNLIVTHQVDNGKSQYYQGLAFKDLYHMCREAFIVSSDLALRAQLTEFVDHKMLKMKRSVDGTEYLVIPLASTLLQKFLDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAZ5</accession>
    <name>A0ABM5IAZ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028128904.2">
        <property type="nucleotide sequence ID" value="XM_028273103.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273103.2">
        <property type="protein sequence ID" value="XP_028128904.2"/>
        <property type="gene ID" value="LOC114325147"/>
    </dbReference>
    <dbReference type="GeneID" id="114325147"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045013037" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128904.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="513" mass="59287" checksum="6802020134998ED5" modified="2025-10-08" version="1">MFILFLLLDSLNFIRCVRILGIFPIPSYSHQIIFQPIWKELSLRGHNVTVVTPHPLNDSSLTNLTEIDVSFAYDILSSKYGWPKEYLKLPSTLHRLDYLLNNGNDLTMEILKYESVQHVIDQHDQFDLLIVQLSVHRNLLLYGLAFKFHTPIVGISSLGLYLHSHDAMGNPTHPIVSPDVMLNFSGKLSFLEKVQSFLYNIWYRMFYYWYALPKADKIARKHFGEEMPYLGDLERNISLLLINVNPIIHNVRPNVPNIIEINQMHIKERKPLPKDIQEYLDSALQGVVYFSLGSNVKSANLTEKIRKEIVAALGELPYKVLWKWETDYLPDKPENVMTKKWCPQQDILAHPNIKVFVMQGGLQSIEEAITFEVPLVGIPLITDQHANVKRIVELGLGVKVDYKTLTKAIFKDAVMEVAQNPTYKEEVKKAKSILLDQPVKGVEKAVWWIEYVIRHKGAKHLRSPAADMSFFEYFMVDVILFLLICITLVLYSVYKLMTVLRSILRSLKRIKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE09</accession>
    <name>A0ABM5IE09_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor II-I repeat domain-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130744.2">
        <property type="nucleotide sequence ID" value="XM_028274943.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274943.2">
        <property type="protein sequence ID" value="XP_028130744.2"/>
        <property type="gene ID" value="LOC114326546"/>
    </dbReference>
    <dbReference type="GeneID" id="114326546"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="503"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130744.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68771" checksum="49CC56BD83C67D2A" modified="2025-10-08" version="1">MEKKRKIDSECRKFKDQWNIQYFVIESSNKALCLICNESIAVLKEYNMKRHYETKHSQNYSKYTGIVRTEKFEALKCGLKSQQSLFTKVKTEQEAATRASFRVALEIAKRGKPFTDGEMIKECIIAVVEEMCPEKVNLLKTVSMSANTVARRVQNIAENISSQLFDKNGHVEWFSLALDESTDVSDTAQVLIYIRGVDKSYEVHEELLDMYSIHGTTTGIDIFKGVEMAINKKNLRWKNLKCITTDGGKNMSGKDKGVVSLVSKAVENDGGSKPLVLHCIIHQQSLCGKCLDMSDVLKPVISTVNFIRSFGLNHRQFRQFIAEIGETDLPYHTAVRWLSCGKVLQRFFELRAVIEIFLNEKHRPLTELQNNAWLWKLAFYVDLTKHVNELNLRLQGENQHLPDLYTNIKSFRMKLILFQSQLRSKCFSHFKTCEIFSHTTETEFPIDFAIETLSALKINFDTRFSDFDAVANQIKIFQNPFDADIETLAPELQMEMIDLQCSDIIKNKYENSSLLEFYKSLPLTQFDNLHKFARGLFSVFGTTYLCEKTFSKMKYTKNVYRSKLTDEHLKSLLIIGTSKISPQLQTIVGGKSQLHTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFC6</accession>
    <name>A0ABM5IFC6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131537.2">
        <property type="nucleotide sequence ID" value="XM_028275736.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275736.2">
        <property type="protein sequence ID" value="XP_028131537.2"/>
        <property type="gene ID" value="LOC114327198"/>
    </dbReference>
    <dbReference type="GeneID" id="114327198"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131537.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="982" mass="111061" checksum="600CEC298842045F" modified="2025-10-08" version="1">MSMLAEPRRKQKWSLNPRGKEWSQDANKFGQKMLEKMGWQSGKGLGAKEDGIKEHIKISYKNDSKGMGYKESNDQWTEHETHFSALLESLTGDEKNVEKKVISLEQKSQTSRARVHYKKFTRGKDLSQYSEKDLANIFGRKSLKKPKKEVEVKEEYYDSKENVTSNDMLVNAGSMRDYFKKKLKLPNLGKSNGYVIGSNGVLQKESEAESESESRPTFGFGFNVKEEAEPDTESRPACGFNVKEEIKSESESEMRPSFGLGFSSSASSKPKKESSKMSFVSYISETPVKRSAEEHEEVVLSPKKKSKKNKQKNEESTVVGISNPSFNPMGTPVKVERHSLNPIEEVSTEIEDSLKKKSKKEDNLECSLDNLEDSSRKKKKNKKNTSIDTSEGASEVVTKKSKKVEQNLEGIANPAFAPMGTPLKIQRHSLDVIEESITEIDDSMNNSNSKKKNNLSTNIEQLNDESVESVKKSKRKKNTNDVCEFNNPTFCEIDENTQAADTENNSYEVSTKKLKKEKKKKKNIGNTDETISTAVEISIDNPNFDATENEDAPNCTEIEQNPYEVKVKLKKEKKMKKNVGNTEETISAHIEIAIDNPNFDATENEDAPNCTEIEQNPYEVKVKLKKEKKMKKNVGNTEETISTHIEIAIDNPNFDATENEDAPNCVEIEENPYEVKVKKKNKKSKNLEIDNPNFDDTQEDSINVSQIEENPYEVKLNKKKKKKKDKKLANDNAGFVDNPETPIDSVNPYEVKPKKKKKATSEDSGVVNPAIDLNTPKAEESVDLVECDLMLNIVSTPVRTEEKKTVSSVGSVSRVESVKSRRSVRFSDVTQEFIIPNNEELKEMSKKGKKKKKGLDNFNFDKQQTSLDENVDTIARTLDDFQAEIENDINEEKTKELTEFTAEDLMVGEVGNPHGENEKLADGTKLKFKYANMETKTPFYMLNKVGAKKSYKHLIKGDILVKFKNTNLHELKGYATKNTNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGK8</accession>
    <name>A0ABM5IGK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132302.2">
        <property type="nucleotide sequence ID" value="XM_028276501.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276501.2">
        <property type="protein sequence ID" value="XP_028132302.2"/>
        <property type="gene ID" value="LOC114327791"/>
    </dbReference>
    <dbReference type="GeneID" id="114327791"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="331"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132302.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125581" checksum="5D3CE01ADDBDAB5A" modified="2025-10-08" version="1">MMPKDIRSYFTPVSKNNTPSKAANQKKKSKRLIDSDEEDVIESTPEPCKVKSFSSKRKPEAVLLSSDSEEDKPKKPVKDPTKLKPINIDDVFSSKPIQQAKIKELPKGEAVIVEHKDKSHKHKKKKTKTEIGVHEDEAFEKTLMELDDDLLADNLDILDKTADDALNIKTTHREGVKTKSKKGSNNKDTPVKDSKREEKHEDEIKKKKMETESEVHTDEDFNKTLKDLDTESSKSNQSCTKPKIVVDDVEPKQSSSKENSPNKSNDEKRTKRHRSPSKGTTPKKPKLEQSDPDIDPDQEAFEKRRYSAMLYQKYKNRGGPKMHGQKELPKGNPDCLKGITFLRTGVLDSIDGEEFQNLVVEHGGRVVHAVSKKVNYLVVGEEPGPSKLDKARGFKIPEINEDQFLDLILIKSGMKAKYYHKDSSDSGVFEEDIDNDKKNKKQKEEHEKNKVPRNEEKHSNKGKRSESSPKDIKKSSMKNKEKQTNGNSSKPDTKEEKIVTSKFFDTKKTSAETKQSTDFLKTSSFYSNKEKKPEKQPVTENIESPITVSDLSMTWTEKYKPTDIKSVIGQQGDSSNLGKLKKWLSNWYRNQLPEVRKKIPRPSPWAKNDDGAYYKAALLSGPPGVGKTTTATLVSKELGFDVVEFNASDTRSKKLLHEEVAQLLSTTTIAGFAAGKTKTDKKRVLLMDEVDGMAGNEDRGGIQELINLIKTTSVPIICMCNDRNHQKMRSLVNYCFDLRFSKPRLEQIRGAMMSICFKEGLKLSPNILSEIISGTGCDIRQTLNHLTMWSAQKDNLTLEEVQNKAKQSKKDTVLGPWEVVRTVFTESEKKNMSVADKARLFFYDYSMGPLFVQENYLGVTPNCPKSEVMKRVALAADSISRGDLIDAKIRGSNNWALLESQAFFASVLPGHYMSGHVSSRINFPGWLGKNSAANKRKRMLNELHVHTRMSTSGSLLAMKLDYILPLRNAIITPLLKEGVNGIQEAIGVMNDYNLLREDLTNLLELCQWKDMKNPFNDIEAKVKSAFTRAYNKSAKQLPFAPGTGFSKKKSSQVDDPEGEDNLLESDNDEADEENDDVTHDALIKVKTGNKKENAKATTSKSSESSKGKGKGKGKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IID0</accession>
    <name>A0ABM5IID0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133486.2">
        <property type="nucleotide sequence ID" value="XM_028277685.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277685.2">
        <property type="protein sequence ID" value="XP_028133486.2"/>
        <property type="gene ID" value="LOC114328736"/>
    </dbReference>
    <dbReference type="GeneID" id="114328736"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="179"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133486.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="425" mass="48734" checksum="6EC8E9A079D2A1CF" modified="2025-10-08" version="1">MDQDDEIAAAAAAYIVLSAKKKKRKHKCWVKPSLCDRSEYGGMHLLNVLKKDDVYIGNNKNNGSVKNFLRMSSTDFEWLLCQIAPKIQKEDTNYRQAISPMERLLLTLRFLATGDSYHSLMYLFKISVSSISRIIPEVCKVIAEVLKDKLKMPQSREEWLITGHQFANLWNFPKCAGVMDGKHIMIQAPKHSGSEFYNYKSFFSVVLFIVANANYEVMYLNVGSQGRIYPTVECLTVLISKKMLYQNTLNLPELEPLPGRTKAVPFVFLGDDAFPLSPNLLKPYPGTQEKGSSKRIFNYRLSRARRISENVFGIMSARFRVLRKPMLLEPDRVELVVAACVYLHNFLRSSLHSRKSYSLPGTFDSEDKDTGERIPGSWRNEINNNMFASLQKQARNSTLEAKQVRDEFAQYFMSPEGMVPWQNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IL77</accession>
    <name>A0ABM5IL77_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nas2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135439.2">
        <property type="nucleotide sequence ID" value="XM_028279638.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279638.2">
        <property type="protein sequence ID" value="XP_028135439.2"/>
        <property type="gene ID" value="LOC114330310"/>
    </dbReference>
    <dbReference type="GeneID" id="114330310"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135439.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="201" mass="22372" checksum="A0767BE0D60F4F76" modified="2025-10-08" version="1">MSREDVREEVLELMSKKDKIEAEIKDLTCILTQNGVGMNEPLVDDQGFPKSSIDIYQVRHARHRIICLQNDHKSLMKQIENGLHGYYSATSLGSNLNNAVAMETDLCDAVVHTEPFAKVTIVSDNSPAYFAGIDVGDLIVEFGSINKTNFKLITDIGTLVQHTEGNPLNVKVKRGDRFFTLQLIPKKWIGRGLLGCNIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INM3</accession>
    <name>A0ABM5INM3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028137448.2">
        <property type="nucleotide sequence ID" value="XM_028281647.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281647.2">
        <property type="protein sequence ID" value="XP_028137448.2"/>
        <property type="gene ID" value="LOC114331956"/>
    </dbReference>
    <dbReference type="GeneID" id="114331956"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044980364" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137448.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="566" mass="64028" checksum="198FBD94C60C17BC" modified="2025-10-08" version="1">MSPLPFVALFLISISFSLVTGEDVLVKLPLGTVKGKTRTTITGVKLYSFQGIPFAEPPINENRFQIPKPKQPWSGVIDATEEREICLQMTSDTVAGQEDCLFLNVFSPKDPAENASLPVMVYIYGGGFIEGSSQDVNVGPDHLMNYDVVYVTFNYRVGPFGFFSTGDDVVPGNAGLKDQVQALKFVKEYIEYFGGDPNKVTIFGQSAGGASVHYQVLSPMSKGLFRGAISQSGSALSAWAYQSNQTEISYLLVKLLNPDLENASSSEVYEYLKQLPAEKIDRAAHIIQRMEKPADNQIQQGFYFAPVIEHEHENAFLTKSMYEILKNGDFNTDVKLMMGVNSEENLFYVGNMTNLEQLATEISADHSILIPRGLHAKESDRAEVASKIKEFYSPYIDFSQDYRSLIKYFSDQSFARSLVKSAELHSKWADVYFYEFMFHGVLGSFVDESVIGFSEDVRHGEEISFILRRNYGGLNTTDLSKYPEIDQTVQKRVIKLWTDFAYKYLNPTPEPVDLLQNITWPVVKPDAFQYLAIGAWLEVRWNPKSEMYYFWTQIFDKYGVPPFNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRV6</accession>
    <name>A0ABM5IRV6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140071.2">
        <property type="nucleotide sequence ID" value="XM_028284270.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284270.2">
        <property type="protein sequence ID" value="XP_028140071.2"/>
        <property type="gene ID" value="LOC114334219"/>
    </dbReference>
    <dbReference type="GeneID" id="114334219"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140071.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="850" mass="92961" checksum="2E3A790238238BFF" modified="2025-10-08" version="1">MLSSISTSVNNSDSEEEFVALRCNDCCVNFTSKHYLYAHLFHHIRQPIIILERIQLPPLKITLKSKSDNSFEIVSSPQRQSPKLTNSDTEDKSPASNLAVIKEEIDSEDLPQSEHAQKPVVEHAQKPVVEDAQKPVVPPSPTQTPDQILADDDMILEEPDFAAVEELIRGATSPTASDSGFTTTSTTTTDGIPTGSSNSESNTSDYGSVPGAEPTPPPEPTPVEYPKIRIKTTGLLKEPLTITEITDDNPNGDPSYNQSSDSSNLWSNSNLEDPLKLPDNDDNNIMSLFNNNERAKDLGFHSSDSEFISLDRLEDRNRGAMQLYNPSNNQNQSTLDTLTGLPMQALAQQVSRLQSSSSSNGLHQQNVLINIQQFPSGPPQPSYQPPPMYPYPPQPMQPYQYQPSYRPPNPMYYPPGPPGYPPQHMPPPPQPQLTQLGQPPMNQQQMNQPPMSQPQMNHNQMPPSSQPQNMNQQMQQQPTPYRQPMPPRQPAPRPPQPGNRMPNPPRPPMAQRQPVSRPRAPMVRPRSATGMTAVRSVRPRMATPQNNIRPQNSPVKRTPEQSQQMQTKKKKFDLLTPDKDDDDCQVICMQPKNTDGGLPQIESVLGGTSETAESSIMHLSDSITLSVRNPPPKPAESPKKSDAKAVANILATRGITVTATAKPKETVKESPSKAASPIPTPINLNGAVSIIPAAKTNGNQKSGVTESLPTVDLTDDSPTPPASSPQKQRPGLPFRCDLCPAQYPNSVGLNKHRQTYHKTTSGMAELGIPVINLKTPGVMQKLSNLGICNYIPLPSQNTADGTFAVPIINSRNPANLSSIGSTTMISLGPIRSIPKPQNNVNKQLNSPQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXG1</accession>
    <name>A0ABM5IXG1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147023.2">
        <property type="nucleotide sequence ID" value="XM_028291222.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291222.2">
        <property type="protein sequence ID" value="XP_028147023.2"/>
        <property type="gene ID" value="LOC114340475"/>
    </dbReference>
    <dbReference type="GeneID" id="114340475"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147023.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="208" mass="24381" checksum="05F8F3572E931D36" modified="2025-10-08" version="1">MGLSRQEVNLRRLLAKCELMCKTKKEDDKIEKYVETLEDMLQEVKKLTDSSESIQSYNKRIKDIKAAVGITKNKYIDENDIASMRNDLLGLRQRFVDKAETTKADDFDQVIEFHENMQRKITEDMLHLTKTLKEQSETANKIIKKDTEVVSKSSELTDKNFDKLSVESSKLAEHSKRAWKCWMWIMLALVVAVFINMVLFMKVMKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IY68</accession>
    <name>A0ABM5IY68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028148741.2">
        <property type="nucleotide sequence ID" value="XM_028292940.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292940.2">
        <property type="protein sequence ID" value="XP_028148741.2"/>
        <property type="gene ID" value="LOC114342156"/>
    </dbReference>
    <dbReference type="GeneID" id="114342156"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148741.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="302" mass="33266" checksum="6D43070AD5F18FB6" modified="2025-10-08" version="1">MNAVGHLCSFVVGPLVSVQGYAYFLLIPVTIFFVTFVPFVPESPYYFMAKDDTNKAEKVLKKIHKNSDTSKELLHIQEVVYTSKHQKVNFKGLTVAPTQNAMIACCGLLLFQQCMGIPFILLYLQPILNASGNIIPSSLASIIIGFVQIVLCSVATLLIDRLGRKILLQVSSTGSIVSLVGLGVYFYLQSHSYNVDPIFWLPLASLINFYVFFNIGYATIPWTIGGELFATNVKYICVSIGSFGALTLGLVIVAAFPFIRETFGMSGVFFLFSGIASFTIIFVSIFVPETKGRNFLEIQNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH05</accession>
    <name>A0ABM5JH05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497221.1">
        <property type="nucleotide sequence ID" value="XM_050641264.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641264.1">
        <property type="protein sequence ID" value="XP_050497221.1"/>
        <property type="gene ID" value="LOC114333324"/>
    </dbReference>
    <dbReference type="GeneID" id="114333324"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20065">
        <property type="entry name" value="FH_FOXP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047412">
        <property type="entry name" value="FH_FOXP1_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="521"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="521"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="752" mass="85095" checksum="EC86272D9836873B" modified="2025-10-08" version="1">MCSKVVKGHIGDVPFESAVGWTSKNHFSATASSWPLTIGQSRYSDDGTMDHDIDGDGVINLSTSQRPSAATTPNIIVHSTNTEQQAASLEKVIKEQQQQLELDRTWEQERERDIKGNGSSSPVSDHRTQEHSPPPSSDAQKNLSATIPPIQQNEPTKLPPNEYSYSQAQTPGPPLMSSPTSNLHHMQQLLQQHVLSPTQLQTLMKQHSILQQQQQQHQQHQLAEIGKKQIEQTMQSLQEQLQLNLIQQTHILQSTDKKKASTSIQQLALQQQQLIQQLQLVQRQYVVHQGMGMQPLMLPQSQSLNSREVMSPWKELNDPHMTNNKPSLDLNDTSPGLLGIPPSRSSRDEPMDDKPDRSTTPDRVHHLYGHGVCKWPGCENPCENLDAFIKHLNTEHILDDRSTAQARVQMQVVSQLELQLQKERDRLQAMMHHLHLSKQMSSPDPHKDSPVGSVKLPVSSALPQPPVSMGPMVSAVRSPVLHSPAPNVAGPIRRRLSDKSALSLAGEIQRNREFYKNADVRPPFTYASLIRQSIIESPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAVRHNLSLHKCFMRVENVKGAVWTVDEVEFYKRRPQRCSSGPLTQPVVGGATSKSPTMNHSPTMYGDHLPSNVQFMQASLMDENNLSFLTTSSLLVNRTRDRSESPPHDHLIRSPMNGGLHVKQELTQDHHMRSDRDRDRDHEMHHVIKREMLSEYEDLDQEQSENVAEDLTIASDHTESNIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIK7</accession>
    <name>A0ABM5JIK7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheine phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inactive pantothenic acid kinase 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with PKM.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497778.1">
        <property type="nucleotide sequence ID" value="XM_050641821.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641821.1">
        <property type="protein sequence ID" value="XP_050497778.1"/>
        <property type="gene ID" value="LOC126878948"/>
    </dbReference>
    <dbReference type="GeneID" id="126878948"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1700.10">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035073">
        <property type="entry name" value="At2g17340_3_helix_bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF35">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-0944">Nitration</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="13">
        <location>
            <begin position="71"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="392" mass="44739" checksum="6ADC4290B36376C4" modified="2025-10-08" version="1">MRFAANLSPTSRRQAPANALINFYAKVKKIILTMTGNEKYVCPLLKNPERYNPDTLNLVENLQARNYWLPCLEQMVKKFVSKAQYLHPDDPKATEKAEVCYQDFHNLLEQLTSDPNILKPLSVRTLLEFNENNLRSKYFKDAWLVQKENESTNALSQFKSRIKQIDSIKDFHSRWFEIIQGVLAGNVFDWGAKIVIDILESNKGNFGFDEATKTIQKRPWFSDKLDEFVDKLKVKPYKTCIIFVDNSGYDFVLGILPLAREFLSQGTKVVLTANSYPALNDVTFQELNIYCKKAADYCKIFERSLFNGKLVTVENGQKGPCLDLADLSAELCECMKSADLVIIEGMARAVHTNLYTKLTVDCLKLAVLKNEWLARNLGAEKFSVICDFDSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLX3</accession>
    <name>A0ABM5JLX3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498939.1">
        <property type="nucleotide sequence ID" value="XM_050642982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642982.1">
        <property type="protein sequence ID" value="XP_050498939.1"/>
        <property type="gene ID" value="LOC114337115"/>
    </dbReference>
    <dbReference type="GeneID" id="114337115"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126919" checksum="A0BF7A2B974BCDA1" modified="2025-10-08" version="1">MEVTVTVTHLKKSKKKYKSGYQSARAKKIFELLNIPRYETQGLSNSERNEVLQRYNDFNNIQVNSNDGQITPDIQNDHYITEERSQYVNTWLLKNLQDHPSVEKKRFTSTNSDSIQIVYLAETTKARCLLFEKNLNNNFAAISDLKNYAQFTSEPENISLLNTNPKNSVTTSNVEEYPVISNVEKCPVLWNVEEYCAVTNSEMQNLTTCNNRSLLSEEISAQRIKSDVSLNSAQSNRICKSKENPIITSVDSNNESLSSLDMSEKLSDCSVFSKSHSEYQPSTSYVSDTESDQSLTLTEKSDELLISPTITVDSNTTTSKHNKNKKSSLDHKSSNMSSKHTKPNENSSKHHKRKGRKTVPKSQLDTSNDSEEHVIVVRSAKKNKSTGQRVRDKGHCCLFCDKIMINIARHYELVHKNEIQVAKILIMPKGSTKRREAFAELSRTADFYHNCEVLNQQKGELILVRRPSGKETTSLSYSSYGPCPHCLGFMLKRKLWFHVKYNCKSSFTSAESSSKKKSIIADSNALLIGLTCTDYSFEYQANILNKFKNDHISTVCKQDSTILKFGYLQFQKHGPTQCELIRQTMRQLGRFLLEVKSLHSDIKELADCLLPNNFDVVISSVKRLCGTINSSTNRPQFEIPSLALKLGHALKKCLNIHRGVALRSGDLRKDELYRSFLQLIEMEWSSKISSCALSTMHKKKFNHKQLLPLTEDLLILTKFLNQEIERLKNKLSLDVVYKTWRALASCTLARIILFNKKRSGEAAKMTVEQYATRPTFKEQGTQELFASLSPLEKNLASTMEVVDIEGKRGRRVPVIITPELKSAIDLLIKTRSTVNISKNNPYIFAPAESEIGHLRGHDCLKSMCNEVNLQHPEYITGTKLRKYIATVSQIFNLGKNEADWLARHLGHDIRVHRDFYRLHENAVEATKISRLLIAIEHGDANKYAGKSLNEINIEDLPCLEEESEEVALPADAGEGINNTEDTSSDDEIPLSNIKEQVFMNQGKRKSSATEEELISTKKETQVKKRKKEKQSAKTLKTTQKTPWTSEEIKSVMTFFKFDLKKELLPGKQKCEECKSKYPVLERRKWTDIKFYLKNYYSRNKRLINNNDNKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMG5</accession>
    <name>A0ABM5JMG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499131.1">
        <property type="nucleotide sequence ID" value="XM_050643174.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643174.1">
        <property type="protein sequence ID" value="XP_050499131.1"/>
        <property type="gene ID" value="LOC126879860"/>
    </dbReference>
    <dbReference type="GeneID" id="126879860"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29446" checksum="993D10BB1487F435" modified="2025-10-08" version="1">MSRTMNAAEETYVELKQSAEAVGLAINTNKTKLLIQTRSNRPADDIEHVNRFTYLGMDLVASSEEEPEINRRLVLANKAYFAMGHIFKSRDVHRKTKLRVYKTIIRPIVSYGCETWVVTQKSANALDVFERKVLRRILGPIRENNNWRIRYNREIYEQYSEPTLAQHTKLQRLRWAGHVVRMHENRIPRKLLNARMQGRRQVGRPKNRWEDEVDEDARNFLGTRSWKRTAVNRNDWRSLLKEAKARFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JN92</accession>
    <name>A0ABM5JN92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498751.1">
        <property type="nucleotide sequence ID" value="XM_050642794.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498752.1">
        <property type="nucleotide sequence ID" value="XM_050642795.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499410.1">
        <property type="nucleotide sequence ID" value="XM_050643453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499411.1">
        <property type="nucleotide sequence ID" value="XM_050643454.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507328.1">
        <property type="nucleotide sequence ID" value="XM_050651371.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507329.1">
        <property type="nucleotide sequence ID" value="XM_050651372.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507330.1">
        <property type="nucleotide sequence ID" value="XM_050651373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507331.1">
        <property type="nucleotide sequence ID" value="XM_050651374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507332.1">
        <property type="nucleotide sequence ID" value="XM_050651375.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642794.1">
        <property type="protein sequence ID" value="XP_050498751.1"/>
        <property type="gene ID" value="LOC126879620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642795.1">
        <property type="protein sequence ID" value="XP_050498752.1"/>
        <property type="gene ID" value="LOC126879620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643453.1">
        <property type="protein sequence ID" value="XP_050499410.1"/>
        <property type="gene ID" value="LOC126879987"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643454.1">
        <property type="protein sequence ID" value="XP_050499411.1"/>
        <property type="gene ID" value="LOC126879987"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651371.1">
        <property type="protein sequence ID" value="XP_050507328.1"/>
        <property type="gene ID" value="LOC126884985"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651372.1">
        <property type="protein sequence ID" value="XP_050507329.1"/>
        <property type="gene ID" value="LOC126884985"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651373.1">
        <property type="protein sequence ID" value="XP_050507330.1"/>
        <property type="gene ID" value="LOC126884985"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651374.1">
        <property type="protein sequence ID" value="XP_050507331.1"/>
        <property type="gene ID" value="LOC126884985"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651375.1">
        <property type="protein sequence ID" value="XP_050507332.1"/>
        <property type="gene ID" value="LOC126884985"/>
    </dbReference>
    <dbReference type="GeneID" id="126879620"/>
    <dbReference type="GeneID" id="126879987"/>
    <dbReference type="GeneID" id="126884985"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="150302" checksum="AD9B2D1FA701AC3C" modified="2025-10-08" version="1">MIKEIVKQSDNLLLTIKRLRKIIFDKFTQNDAKVWLKRLNAHICKCNNLIKAKKLPIGTARKLQSNVGHFKHFRRIILNFNRRVGLGLNSKLRNRVKWENVVSSFASRIKTGVIINLYHKDVGPFLDDAFTVFKQKVKTVLKSNRILKVNTTLWGEFIKKTGDSESLDLIHFNTKNVIIDSYSTDLHIWFSENVKDIIFKKMSEFAEKGSGAALSKVISLEVNINKVEIGNGSSYIKIPEQIQKRHACINIKNYDQNCFYWAIISSLYPAKIHTERTSAYPYYSTALKTEDLEAPMPLSHITKFEKINTISVNVYALELNQVKEKQFYEVVPARLTQNKLDRHVNLLLIQDKYFPKLNDYDAPPSDDENIEIKYHYCWIKDMSRLLSSQLSKNEHKKYICDRCMNYFYSGNKLAEHEEFCRDINKCKMTVPKYDHVAFRNFTYKQTTPFIIYADFECQLHNFTDSNVKLSKTAKYQKHVPYSAGYYFKCAYDDSLSYFRSYRGENCMEWFAKEMAEISKFVDSKIKSIVPMVKKPSTSKATVCHICEKRFLATDIIVVDHDHFTGEVRGFAHQACNLNFRKVFVVPVAFHNFSGYDSHFMIIDLCKHGHLSLLPINKEKYISFTLHSDEHKIRLRFIDTMRFMGASLDELASLLDTSEKKILKQEFYSLDDDAFNLLTCKGVFCYDYVDSLEKLEETSLPTISHFYNKLCDEHISEQKYAHAQKVWCTFECKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYHLDPAWYYTIPGYTWDCMLRYTKCRLELLKDVDMILFIEKGIRGGISVCSNRFSEANNKYMSTYDPTQPSKYIMYLDVNNLYGWAMSEYLPFGGFKWIEDVTKFGLASKSTKLPKGHIDIMSIPNAAKEGYFFQVDLEYPLELHDKHKDFPFAAEHRIPPGSKQPKLLPTLFNKSKYIIHYRNLKQALSNGLILTKIHKVLKFNQSAWLRPYIELNTNLRAASKSSFEKNLYKMMNNAVFGKTMENIRRHRTVKICKNWNGRYGAKNLIASIRFHSRTIFSENLVAIELTKSVVCFNKPLYIGAAILDISKLCMYDFHYSFMLPTMGEENCMLLYMDTDSFIYELQCLDAYKEVLKAHNSKFDTSDYSENNPYMIERLNKKIPGLMKDEANGKIITNFIGLRSKMYTFKLQTTDEEREKERERLKLKLNKEQIDCGIQNLGITKKAKGVKYNVVKNIITFEDFENCLKEYKIKSTNQRCIRSYQHSVFSIEQTKTALSPYDDKRYLIPESFKTLPWGHCDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQK0</accession>
    <name>A0ABM5JQK0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500217.1">
        <property type="nucleotide sequence ID" value="XM_050644260.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644260.1">
        <property type="protein sequence ID" value="XP_050500217.1"/>
        <property type="gene ID" value="LOC126880415"/>
    </dbReference>
    <dbReference type="GeneID" id="126880415"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046570476" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="79"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="331" mass="36164" checksum="71F46D2893A69D54" modified="2025-10-08" version="1">MKAAFIITLLLPVVLSYKGSPNPLSNEFINYINSKQSTWVAGKNFDENLSIQEIKNLLGAKTERLGVAKEFLHSENIQVPDSFDARENWKECSDVISTVADQSSCGSCWAVAAASAMSDRRCIASNGKLKIPISAEDLMSCCSDCGDGCSGGYPDAAWDYWHETGISTGGVYGSKQGCRPYSLKPCEHYVNGNKVPCSSLHYNTPACTHKCDNPRLNYASELTFGEGSVQSFKSVEDIKKEILTNGPVEASFLAYNDFLCYKTGVYQHVSGDIAGGHAVRVLGWGEENGTPYWLVANSWNEDWGDKGLFKIILGRNEVEFESGMVAALPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS27</accession>
    <name>A0ABM5JS27_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500742.1">
        <property type="nucleotide sequence ID" value="XM_050644785.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644785.1">
        <property type="protein sequence ID" value="XP_050500742.1"/>
        <property type="gene ID" value="LOC126880738"/>
    </dbReference>
    <dbReference type="GeneID" id="126880738"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046686285" description="Peptidase metallopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="84"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="517" mass="60026" checksum="44026DF28ECAA74C" modified="2025-10-08" version="1">MEVFLICVLLLRFIAATDAFSEDDAMKFLQRYGYIDNNYIADFNTTLLHFQEQYNLYVDGTLNDETIGLMQKPRCQTGENDYSLMGKWYKHNLRWYFPQANHVKDIIQLVERAFKMWEDASNLHFTRVTVPVPKPDITITAVKRKHYFRSNCMGNQKCGIQFDGPGGKLAHSYFPIDNDTCVEIHLDLDEKWSYNLNDTDYDFTNLFMVILHEIGHSLGLLHSNDESAIMYPWYHNKVRNISQDDISGLEALYGRKSTDAYIPTQTSAPTRSTSHISRVHTTRSRPRPNEIIPQQSTKATPHFCVIEYPNILFLAYDPQFKNHHMYIIHEGFVWKNDLNGHMVPNNPEHLSTYLPKQIRNISHVFQNIAGNLIVASNNTMYSVSFPSITISRDIPLFVLPPHAEINVVFQTHTGKTYIWYDNTSFIEYDDLIDLVISRGLIKDIFPGVPTTVKSVFKYIDGHLYFLDGSTYYKYNEFTKKMIEIGRFNWNLFGIPCPDDGLVTQLKYLLNKVGSFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU22</accession>
    <name>A0ABM5JU22_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501437.1">
        <property type="nucleotide sequence ID" value="XM_050645480.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645480.1">
        <property type="protein sequence ID" value="XP_050501437.1"/>
        <property type="gene ID" value="LOC126881284"/>
    </dbReference>
    <dbReference type="GeneID" id="126881284"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="305" mass="35180" checksum="149B1F5147FB6E31" modified="2025-10-08" version="1">MESYDIRLKRTEYLKQLIKFRSEGRNIIYTDETYIHSSHTPPYYWGDQSGKTFKKPISKGKRLIIVHAGGETGFVPNALLIFKSGSKSGDYHDDMNHLNFMKWVRSQLLPNLPKNSVLVVDNASYHNVTMEKNVTSASRKDIMVKWLQEKSIPFPVNLTKPELYKIIKVHKPRFPSVYVLDHELEQHGHKVLRLPPYHPELNPIEKIWALVKGRVASHNATCNINDVENITKKKFSEVLIQEWASICKHVNKYEDTLIKKEHLLDATLENLKFFINTGSSEESFSEDEDSDSNSGIDILEPSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU92</accession>
    <name>A0ABM5JU92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501508.1">
        <property type="nucleotide sequence ID" value="XM_050645551.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645551.1">
        <property type="protein sequence ID" value="XP_050501508.1"/>
        <property type="gene ID" value="LOC126881331"/>
    </dbReference>
    <dbReference type="GeneID" id="126881331"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF209">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1190"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1223"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1248"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1291"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="534"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1379"/>
            <end position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1720" mass="193299" checksum="BB738E11E0B3237E" modified="2025-10-08" version="1">MGEEVTEKTRIQPKNMAELKHSLYLSQLRAMLKRNLLLKKREKRKTTAEVLLPLYSLAILIVIKITMPNPNLPAIDTPRGEEELLHHFGKVESHTIAVVPNTSEVVYFLEQIDNLWSSISYMNLSKINWVLYASEKDLMSEYWHRPKYIPIAVLFDNQDPLDGPLKYEIRTNPSIIGTPPTSILYSSPLACRDTNNKWYSYARVIPAMEGGDSCPVNQYYFSGFLALQALIDYTRIRIDTNADLKVPQLLLEMFPKPAHTGNWMFLIRIIIPIYMVMALSQFIAYLLILIVGEKEKKIKEGMKIMGLKDSVFWLSWFIIYGVFVLFLSVVCVVLLYSLKVFIHTNFLLIFILIVLYCFSIIMFGFMITPFFDKSRTAGILSNFVVIIMSMFYFVQVFLKDSNPIALWFMSLISPSGFALAIDNAIVMDLSGEGVNISNIWSGRGVPFGGSLIMMAVDIVVYGLLAYYLDSVIPSEYGIKRPPLFCFKLSFWFPKKTLQKIPLANGESSEHSLNNTDYTLDVEPVPREMRGREAIKIVDLYKTFQHCQKPEIKAVNGINLTIYEGHITAILGHNGAGKTTLFNILTGLTAPSAGTAYIFGHDVRDPNDMDAIRRMTGVCPQHDILFDNLSPREHLEFFAAVKGIHPSLIEFEVMKTLRDIDLTDKANSSSKHLSGGQKRKLSIGIAIIGDPKIVILDEPTAGVDPYSRRHMWSVLQNKRHGRVILLTTHFMDEADILADRKAVVSKGNIRCCGSSLFLKNKFGIGYHLTLVLEGHSKENAINKLVITHVPKAEKARRHGRELSFILPHNAVSNFASLFSAIEQEINNKSSKLGISSYGVSMTTLEEVFLHLERDEETEEDTVDNLSKKIVRNRALSRSLSLQNKSTSYQSLQNESNNALIQDAKAAGDFETCESPIKGIGLDSIECHPNWFQTLIALLRLRILRLRRDIKKLYVMIFLPLGLAVLGLFVNSMETGQLRTKSLVLNLTTYPSMPIAVHNGSDANVDDFLIQLLDLGVDVLDDYDGNFSSLLNIAPHMVAFNVNRFDYPDYSVTVLYNDTEQHSLPIAVNLINNALYRLLTGEMEISEKWNPIQVRSQPFQQTSSDFSLGMGTATFTMGMIFALIPVTLATDMVYDREIKAKNQLRVNGLSFSLYFISYFIVLAVIMAFICSVLLLLVLLFKTPSLSSWPALTTIGILILFYCPSSILFSTCVSYIFDKTDSAQSIMSNVATFLGWIPFLLVMILGGNVALILHIVCSLLNTMYLPYAIIYFVQRVDLACKSNFGCTELTLKNYMTIEIVVMFVGLILHIPFWFFILLIVDIKKNGGKARDIFKFRKKVVDDFTEDANEASDIGENEDQDVKAERQKVKNLMHNHIINPPVVMVENLHKEYIKSELRCTCCKSEEESETTKIAVKSLSLAVDAGEVFGLLGHNGAGKTTTMKIITAEEAPTRGRVQIAGNSITSNMNSAFQLLGYCPQHDALWKNITVREHLEVYASIRGVPYQSISRLVNSYLSGLQIHEHADKQTHQCSGGTRRKLSFAMAMVGNPKVVLLDEPSTGMDPRSKRFLWDTVLASFQGSKGAILTTHSMEEADALCSRVGIMVKGELRCLGSTQHLKNLYGAGYTLEMKLGGGDMTPTSDSGDRHDELREFISSLFPDAALQEIFADRLVFSVPQQSVPSLANCFKQLEKAKTELDIEEYSFSQTTLEQVFLKFAHESENDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUT5</accession>
    <name>A0ABM5JUT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sorting nexin lst-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501703.1">
        <property type="nucleotide sequence ID" value="XM_050645746.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501704.1">
        <property type="nucleotide sequence ID" value="XM_050645747.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645746.1">
        <property type="protein sequence ID" value="XP_050501703.1"/>
        <property type="gene ID" value="LOC126881472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645747.1">
        <property type="protein sequence ID" value="XP_050501704.1"/>
        <property type="gene ID" value="LOC126881472"/>
    </dbReference>
    <dbReference type="GeneID" id="126881472"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="202"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61983" checksum="6FD66938187B8B3C" modified="2025-10-08" version="1">MGTFTVKVLYDFQGESNTAEMSIVAGETLTVTRTDVGEGWWEGVNSRNQSGLFPEAYVEKASSSSHPPNIPAPVLPPQNDWGDAQQNKEDWDDDDDWDDDTVYSEIGNNHGQSQSIYSNEQNQNQISHQFDNMSLGNLSTAGDNKGTITKKSLNIFSSYVKSGLEGYILGNSASLPVGNKKFTIFRDSDDVLGRWEIMSNPYTVQIASPKKASKMGGLKSFIAYQLTPSFSNVEVSRRYKHFDWLHDRLTAKFNVIAIPPLPDKQVSGRYEEQFIEHRRAQLQEFINYMCRHPVLSTCDVWVHFLTCTDEKQWKLGKRNAEKDQMVGANFCLSIEAPEKDILPSLSEPKIEENLNYIIKLDQCIKNLMNTAQDQQKKCVNMYKREFMRIGECFFALGSSFEYNQQGMYSKASVDVKNIGTTYMAIGKLYGEQAKIDWQPLFDKLYIYKGITSDLPDILNLQKLSEQKKKDCERNSQNPQTAIADIRRRADVLTYTVFSELNHFQNERDTDLRLTMKTFLQEQLNFYKNVVLKLEETLDKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVH6</accession>
    <name>A0ABM5JVH6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501940.1">
        <property type="nucleotide sequence ID" value="XM_050645983.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645983.1">
        <property type="protein sequence ID" value="XP_050501940.1"/>
        <property type="gene ID" value="LOC126881616"/>
    </dbReference>
    <dbReference type="GeneID" id="126881616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="185" mass="21393" checksum="449F3EBFBC39864E" modified="2025-10-08" version="1">MQKHNCQNIQHFFTLPKEPKRRLKWLKACRRDKKDISQKSIGLYVCEDHFDLEQDMDNYIKFKIMGGPKIIKSGVVPHIFNCQPDRKRAFSQPVREAALKRVKRQLLEDTASTNKSVLEDNDDKRQCDPCFTNLVQSGPELNQSALPQKLNNASTQTHIKIRSKGTYSVQISKECYSRVVAIENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWU8</accession>
    <name>A0ABM5JWU8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502407.1">
        <property type="nucleotide sequence ID" value="XM_050646450.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646450.1">
        <property type="protein sequence ID" value="XP_050502407.1"/>
        <property type="gene ID" value="LOC114342351"/>
    </dbReference>
    <dbReference type="GeneID" id="114342351"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14766">
        <property type="entry name" value="CeGLB25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF5">
        <property type="entry name" value="GLOBIN FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="6">
        <location>
            <begin position="37"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="195" mass="21983" checksum="8ADE89080DF7FB92" modified="2025-10-08" version="1">MGCELGKLAGRGHSDNNGKLDDVGPPAQPPQVDSRLPLTAKQKYSMLASWKGISRAMESTGVCMFLKLFEEHGELLNLFEKFKELKTKEDQANSLELQEHAGTVMNTLDEGIKGLDNLDAFFEYLHQVGASHRRIPGFKVEYFWKIEKPFLEAVELTLGDRYTENVENIYKITIKFIIETLIKGYDNANNANAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXP7</accession>
    <name>A0ABM5JXP7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502713.1">
        <property type="nucleotide sequence ID" value="XM_050646756.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646756.1">
        <property type="protein sequence ID" value="XP_050502713.1"/>
        <property type="gene ID" value="LOC126881991"/>
    </dbReference>
    <dbReference type="GeneID" id="126881991"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="196" mass="22727" checksum="1C5ECB4C6AD7EDE1" modified="2025-10-08" version="1">MGYRQNYRSSYRLPDDIYQTTKIAKLLMVMEKGTANKFKGKSLDEVEIDMDKNLLEDNFSESDVDGDDEVKCLLHDDSEPSTSQIRQSMGARIGYYLQILSYCMDFNEILGLASTYLLIQSLPYADVCFYLGGGSHPFLRVENFLVKITTEFAREPNSKQKLFHNFFLKTILFEIFVVENPFRTVFCEYLKNYASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYP9</accession>
    <name>A0ABM5JYP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503066.1">
        <property type="nucleotide sequence ID" value="XM_050647109.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647109.1">
        <property type="protein sequence ID" value="XP_050503066.1"/>
        <property type="gene ID" value="LOC114324344"/>
    </dbReference>
    <dbReference type="GeneID" id="114324344"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="487" mass="57039" checksum="B4D016A251693267" modified="2025-10-08" version="1">MEVKQEISDETCKVEVEYNDFDGAFLDGFKYENEESNRQSAHDTYYYLDLKKSPIDTEIEHENKFNPFEENQKTVKGHLQDDQKMEIMETAIQDSCYEGNYISQHSEGQTLNKNIKVATRRRPYKCEICLKPFSKASHLKTHLRVHTGEKPYKCEICLKFFSQAGSLKTHLRVHTGKKSYKCEICYKLFSRAGSLKTHLRVHTGENSYKCEICLKLFSQAASLKTHLRVHNGKKSYKCEICFKQFIQASDLKIHLRVHTGEKPYKCKICFKQFSIASNLKQHLRVHTGEKPYKCEICFKQFIKASDLKIHLRVHTGEKPYKCEICFKQFSIASNLKEHLRVHTGEKPYKCEICFKQFSLVNSLKTHLIVHTGEKSYKCEICLKLFSYAGSLKTHLRVHTGEKSYKCEICFKQFIQSSDLKIHLRVHTGEKSYKCEICFKQFTHASSLKRHLRVHTEERPHRCEICLKRFIQASNLKIHLRVHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0B2</accession>
    <name>A0ABM5K0B2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503628.1">
        <property type="nucleotide sequence ID" value="XM_050647671.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647671.1">
        <property type="protein sequence ID" value="XP_050503628.1"/>
        <property type="gene ID" value="LOC126882692"/>
    </dbReference>
    <dbReference type="GeneID" id="126882692"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF504">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="10">
        <location>
            <begin position="441"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="656" mass="74116" checksum="F512EC65B451FA3B" modified="2025-10-08" version="1">MIGLEIVSDMAIPNPKSIPNNISEADDNSLRSLSSEDVSQAPRGYCCAKSINPADGRGRKLHLLQMLILPFIPILALIIQTSVLLNNIMVTRNEVMEINNQVTIATELGKVVTRLQLERSEVAFYVYTNGSLLRTNLTKRFELTDEALRNMSSWPPVSLTFEGNKIPYMDKESFQRNLTNFRHTVISEDSSIKDVVSWYTSLNAALLEHLTQQIKENDNSGVWRYLLAFKNLLKSIESTGIAMVYGVNYFGQGILQSQNYINYITHDAIAKDLLNTSLNYVSQMKREYEYVTINMANYSHIKLKNDIIMKNTVRLPNYSEALAYFDMMATYTDELRKIQRSLRVLIQDYVDENLQNSANTEAMGIAILVLVLSVSPVIIWLVRNAVATIQLYAANLAKKAKELKREKKKSDLLLFQMLPPIVATQLKQTRQVPAEYYASVTVYFSDIVGFTEIAAVSTPLEVVTFLNKIYKQFDARIECYDVYKVETIGDSYMVASGLPEKNGSKHISEIASMALDLLSGSRQFKIPHRKSERLQIRSGAHTGPVVAGIVGSKMPRYCLFGDTVNTASRMESTGEASKIHISLDMKRALDLIGGYKTEHRGLVDVKGKGLMDTYWLTCKEGGLNRTVEMDTPSYFPEEDDDVEPVFIKRLRNESYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1T0</accession>
    <name>A0ABM5K1T0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504145.1">
        <property type="nucleotide sequence ID" value="XM_050648188.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648188.1">
        <property type="protein sequence ID" value="XP_050504145.1"/>
        <property type="gene ID" value="LOC126883018"/>
    </dbReference>
    <dbReference type="GeneID" id="126883018"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="42092" checksum="20892109ABECD40D" modified="2025-10-08" version="1">MKTLKESLTENEILFHIDFSENFLCKYANEAQSVHFGASRDQITLHTGMMYHKSKKEGFCTVSKSLRHDPASIMAHMEIIINHYQHELETEFKTIHFLSDSPSSQYRNKKMFFYLQQVLPKLFPQIQHISWNYSEAGHGKGAPDGIGATIKRTADQLITFNHDINNFDVFVKCIQENISNIHIKCLNENNIEKFDAFLPPLPKPYKGTMQTHQVTWNHITRELSFRTLSCFKCSFENCIHYAIENKVAPLQSSYLSEENDNGRATARPTGIEEFSEDTWVTAIFDNDWYPGIIEKIDRNIMTVNFMMKNGKSFFWPDIADRQTVTTRNGILCQLVHPPEPVSNRFYKIQEYDYIDNLFKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2Q0</accession>
    <name>A0ABM5K2Q0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504467.1">
        <property type="nucleotide sequence ID" value="XM_050648510.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504468.1">
        <property type="nucleotide sequence ID" value="XM_050648511.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648510.1">
        <property type="protein sequence ID" value="XP_050504467.1"/>
        <property type="gene ID" value="LOC126883233"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648511.1">
        <property type="protein sequence ID" value="XP_050504468.1"/>
        <property type="gene ID" value="LOC126883233"/>
    </dbReference>
    <dbReference type="GeneID" id="126883233"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="688"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="718" mass="84072" checksum="1BF3AF7F746AF870" modified="2025-10-08" version="1">MERKEDNEDTVTTIKFESSISVNPEFIKKEPALVYQDTPREDYGHGGSDINLDQIKTELSVEDITIGQKGDDLAGFQYFNSYVDNIKVQHFAKGNQSSEHDSFKNEVKEEPNRENTHDTFDDSKLNECSLKIEIEEDEIKLKPHEEKEMNEKDFPQEDTLEIIKTTEVHSSNKEQHTSDPAKEKTFKCEICGKQFGKKHNLNLHMRIHTGEKCYKCDICCKQFREAQSLKRHIRTHTGDKPYKCEICFKQFSQACNLKTHLRIHTGENTYKCEICFKPFSTSGSLKIHSRRHTGEMPYNCQICFKQFNQAGNLKTHLRVHTGEKPFKCEICFKQFSGQYLKRHMRTHRGENPYKCEICFKLFNQASNLKQHLRVHTGENTYKCEFCFTAFSTAGSLKVHLRRHTGEMPHECQICLKMFITIGELKKHLRTHTGEKPYKCEICLKHFSQKSILKQHLKVHTGEKPYKCEICFKPFSTSGSLKIHSRRHTGEMPYNCQICFKQFNQAGNLKTHLRVHTGEKPFKCEICFKQFSGQYLKRHMRTHRGENPYKCEICFKLFNQAGNLKQHLRVHTGENTYKCEFCFTAFSTAGSLKVHLRRHTGEMPHECQICLKMFITIGELKKHLRTHTGEKPYKCEICLKHFSQKSILKQHLKVHTGEKPYKCEICFKQFSKKSILNEHMRIHTGEKPYKCEVCLKQFSQSGSLKTHYFRIHTRKTAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K519</accession>
    <name>A0ABM5K519_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505285.1">
        <property type="nucleotide sequence ID" value="XM_050649328.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649328.1">
        <property type="protein sequence ID" value="XP_050505285.1"/>
        <property type="gene ID" value="LOC126883670"/>
    </dbReference>
    <dbReference type="GeneID" id="126883670"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="630" mass="71427" checksum="1E05F88DF7C0CE4D" modified="2025-10-08" version="1">MGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKAIFRSAYYIAKNDRPYNDHFGLLELQKLNGVDIGVVLHSRYSAVEIIDHISKEMKLRILNKVKEVSGKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSILKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5V1</accession>
    <name>A0ABM5K5V1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505554.1">
        <property type="nucleotide sequence ID" value="XM_050649597.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649597.1">
        <property type="protein sequence ID" value="XP_050505554.1"/>
        <property type="gene ID" value="LOC126883893"/>
    </dbReference>
    <dbReference type="GeneID" id="126883893"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="102"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="45594" checksum="47BE6318E64C2885" modified="2025-10-08" version="1">MAVYFVDKTGKRVPLSHDLALELLNDGNESEIEDLHDENDDVFEIQTFENDSDDQEIKETVLDEKPVPSTSSSKARRHWKDTTFQQKNHDYPKSTPKPIRNAMEYFSDYLNDGFFDLAANCTNNYFMRKTGRMLNTNSEEIKKLIGIHLIMGCIPYPRLHMYWRQGMQLHMVSSQMPRDRFKALRTALHVVDEDIAPEGNTNVLWKVQPIITAVKRACDRLERRPGNYSIDEQIIPFCGRCANGLRQVVKNKPRPQGLKVFVATTSDGLMIDFEVYQGARTPFPDRSLGVSAAVILHLSKSIPPGSCVFFDRYFSSILLIEPQMKLHGTATLMMNRLPERRKIPFKEDRCMKRGESQQFVYGDLVVVKWKDNKSVLMVSNCTSADNKVNMNRWDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K658</accession>
    <name>A0ABM5K658_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050505676.1">
        <property type="nucleotide sequence ID" value="XM_050649719.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649719.1">
        <property type="protein sequence ID" value="XP_050505676.1"/>
        <property type="gene ID" value="LOC126883949"/>
    </dbReference>
    <dbReference type="GeneID" id="126883949"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="9">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="191"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="435" mass="49221" checksum="43293E422E1385C0" modified="2025-10-08" version="1">MPFRICMVSDFFFPNMGGVEEHIYNLSQCLLQKGHKVIVLTHSYEDRVGVRYMTSGLKVYYLPIKVFYNQCVLPSMVSNVGLIRYILVRERIDIIHGHSAFSALAHEALLIGNLMGMKTVFTDHSLFGFADASAVITNKFIHISLSDCNHCICVSHTGKENTVLRAKMESWRVSVIPNAVDTYSFTPNVDQRSKNKSKFTVVVVSRLVYRKGVDLTAQIIGDLCDKHKEVCFLIAGDGPKRGLLEEIRERRGLQDRVILLGGLEHSQVRSVLVKGDIFLNTSLTEAYCMAIVEAASCGLKVVSTRVGGIPEVLPDSLIYLTNATVPSLMKGMEDAINDLKAEKVMCPYECNITVRKFYNWKDISSRTEIVYQKVIKEANKDLGHHLKSYLKSGVWPFVLVVSLVYLMLRIYEYIVPRRNIDIATDYNQKTKKKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K758</accession>
    <name>A0ABM5K758_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050506022.1">
        <property type="nucleotide sequence ID" value="XM_050650065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506023.1">
        <property type="nucleotide sequence ID" value="XM_050650066.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506024.1">
        <property type="nucleotide sequence ID" value="XM_050650067.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650065.1">
        <property type="protein sequence ID" value="XP_050506022.1"/>
        <property type="gene ID" value="LOC126884199"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650066.1">
        <property type="protein sequence ID" value="XP_050506023.1"/>
        <property type="gene ID" value="LOC126884199"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650067.1">
        <property type="protein sequence ID" value="XP_050506024.1"/>
        <property type="gene ID" value="LOC126884199"/>
    </dbReference>
    <dbReference type="GeneID" id="126884199"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="208"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="507" mass="58816" checksum="F8B6E1C63E27E8EB" modified="2025-10-08" version="1">MKPKQRDSFLQWHADKVSENYIFDFQKEIREYCDADVDILRRGCLELRKEFLAVANIDCFQYVMIASTCLAIYRSKYLPTNQIAVVEKQDVYSSAAISWLSLFPGLRHARNGGEVTICGSKVDGFDKDTNTAYQFHESFWHGDPRVYSADTVNPVTKERMGDLYANTLRRSQQIRGAGYNLVEMWELDWINSVDYKKVEHMVKPLQPRDAFYGGRTNATKLLVYGKKLRHIDVVSLYPTVQFYDAYPVGHPIKLYKPAVYDSSWFGLILCTVLPPRQLYHHVLPLRTTKLLFPLCKQCVEDMPETCLHTEAQRSFSGTWTTLEMSKALEKGYKIINIHEVWHFEKTSRDLFKGYVKDFMKIKLESSSHTYESSEEYARVVKEQIGIELDLAKIAPNPGRRAVTKMSLVSLWGKLGQRLILAQSEYITTSKRWYEILLDDTLDITNCLFFEDTIVQVTYRVKEQFVENSNDTNVFIAAFTTSNARLRLYDMLDKLGEAVEHRLCHIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K892</accession>
    <name>A0ABM5K892_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506404.1">
        <property type="nucleotide sequence ID" value="XM_050650447.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650447.1">
        <property type="protein sequence ID" value="XP_050506404.1"/>
        <property type="gene ID" value="LOC126884504"/>
    </dbReference>
    <dbReference type="GeneID" id="126884504"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="460" mass="52296" checksum="6741ADD1B0F83FA9" modified="2025-10-08" version="1">MSFKLDVDRLVKDELEVELQMRGIVLTNCKVEELKSTLRSCLVLEKSGKIPNFDLPPDIPAELTSCENKLKEILNIINAFTGTANQIRRIETKFAHLSGRLNRIHSTDTDEMSKRSALLKKLMDLIGEYTTKSNVLKTSNVVSVEMPTDPNFYHHIDLSGLNLNDPNGNSTPTRNISAPNVSNQANQTSNSTVNPIVSLSSNNFPSEPVYKWGIKYSGKPQNFSVFLEEVEEYCRSRNVNKIQLFSCARDLFTGNALGFYKLYRNYASNWDSLVSLMKEEFTLSADEIWQDILHTTQESNESIGMFVAKMTSKFEQMPTPVPDSLKMQVLLKNILPFYQERLTLVEVKSPFDLIDLCRKIEQTRINIESFKPSSSSRANSSRHHVVQEVEAFVPKCWRCNEYGHVVKDCKRPKRVFRCFGCNKEGFTKNTCPQCNSQNRNNNNSRTGNNSGNNSGNGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KB63</accession>
    <name>A0ABM5KB63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507424.1">
        <property type="nucleotide sequence ID" value="XM_050651467.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651467.1">
        <property type="protein sequence ID" value="XP_050507424.1"/>
        <property type="gene ID" value="LOC114331862"/>
    </dbReference>
    <dbReference type="GeneID" id="114331862"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34434" checksum="A2C727E5C6035998" modified="2025-10-08" version="1">MIGILSVDLCFPFCSKGWTKIIQLLTDFSEFGKPPKIDELTVLGNKRAIGIIIFYFMCAVFYELVSILQAPGCYKDAEKKGLEVNCLTMFPLWLPFDISKMTQLIISLIQYVLLAITTMPAGLGIHLPWEVSEHTYLYIQHLNTLFHYTFETDDKVEQRRRLNKWIKYHHKVVSLVTELNTLTKGSIGVLSLVCSLVVAVTVNQVLKGEKTFAAIVVGVGWFYSLTINCITGQAIINQTASITTNIQSSKWYKGDIPVKKDILFAIMCSQRPFTLNALPLGTLNLELLLMVVQTSYSYVTLLANTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC64</accession>
    <name>A0ABM5KC64_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507777.1">
        <property type="nucleotide sequence ID" value="XM_050651820.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507778.1">
        <property type="nucleotide sequence ID" value="XM_050651821.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507779.1">
        <property type="nucleotide sequence ID" value="XM_050651822.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651820.1">
        <property type="protein sequence ID" value="XP_050507777.1"/>
        <property type="gene ID" value="LOC126885305"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651821.1">
        <property type="protein sequence ID" value="XP_050507778.1"/>
        <property type="gene ID" value="LOC126885305"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651822.1">
        <property type="protein sequence ID" value="XP_050507779.1"/>
        <property type="gene ID" value="LOC126885305"/>
    </dbReference>
    <dbReference type="GeneID" id="126885305"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028478" evidence="1">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="188" mass="20716" checksum="D67F5BDE10367590" modified="2025-10-08" version="1">MKVLIILFVVIAAAMASYGPGGHGGGGYGGGGYGGDEDGDYGGHEGGGYGGHRGTHGGGGHNRGRIHVYQNFILPQEEKDILHNYHLQCQRQSKCGMEYIRSPHQYEDYEPLGKYMLCVCQKYGFMYPNGRFNYDMLSRKLGLVCTDEDPEVYIDGCAVPSANPYSTAVKLINCLDDYGFHYLDQCVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD09</accession>
    <name>A0ABM5KD09_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508078.1">
        <property type="nucleotide sequence ID" value="XM_050652121.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652121.1">
        <property type="protein sequence ID" value="XP_050508078.1"/>
        <property type="gene ID" value="LOC126885538"/>
    </dbReference>
    <dbReference type="GeneID" id="126885538"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="506" mass="57933" checksum="3C474E5F47C9BD7B" modified="2025-10-08" version="1">MDQLKREKSTTKSAITRVLTWITKYLDAQTNSFEIDVRKSMLISSFNNYNQICDNIESLEGGDLVAENRDEVETNYCSAMARLENKLHSLAQSQFNLPLASERNPFIPSNVKLPPISVPTFHGEYSKWVSFYQLFTSLITDNQSISNAQKLIYLKSALLGEPLTLIESLEITNDNFDLALDILKKKYSNDLAIINSHINSIIDYPSFSKSNQTLSEFINESKKHVDSLKLLNVPVKTWDLILINILSRKLDFASKRYYGERRNRSSQPTLTEFFDILNERCNILSDLTHIPESKRDSHSQKSHLAFLPEPNREPHSQKAHTKTHFTSLHSNTSQSTQQTYTHPKCSYCNAFSHRIYSCRQFLALSHDEKHNFIRSTKMCSNCLGTKHSHNDCISRGCSICNRRHHSLLHQDSSEQNRNPSAPRFQTQYNTRSNVNYPKHSTQKDIANNNVRNEDINESRNVQRTSTNSLPSNSSEGTQINSHRPSHHAPINDNTHSSSLIPYSSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG42</accession>
    <name>A0ABM5KG42_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509160.1">
        <property type="nucleotide sequence ID" value="XM_050653203.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653203.1">
        <property type="protein sequence ID" value="XP_050509160.1"/>
        <property type="gene ID" value="LOC126886331"/>
    </dbReference>
    <dbReference type="GeneID" id="126886331"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1653" mass="191272" checksum="5E8708B0E5B17F50" modified="2025-10-08" version="1">MQCFLCKHLSAQTKDFKGIQDKVKEFSNKTWLSCTTSLKARQQHQHQWNDVELPENWDNNEIGYHSQCYKKFIVKKQFLLPESETPSTSVGATISSVDEADNLKTNSSNLSTSWLVCEAAVSYLSTEDYSTNSSFSSAAINLEPVNVSVKCTRQQLSRDADDIENADEMEVDNDIVDDSIVENEQKCQEKCFFCGNISIKWKGRKLYCSQTKHKIRFFDRIRSYATEMNDVEMLMSIHEEVNNENIMLFYHQRCSLKYFSNFKAYTNKPPTTIWTDTRGYNEIARKQLIQYIEKEVVSESKIFSVTYLQDIYILFLQEVYESEGKDFPENLITTNTLRQYMEIHLKKKIKFEYFSKKWFVMSVNTDLENINDDEILDIIFEQECREFAIKYRKKILQIKKKPLPDFLDAEALNKGECDIPNWLNVFWKTALSGTKVETERIERLTACLASDSIYSITKGNIKPRKQIIFGMSMKSLTGNVKVMEILNRCGYSISYSGLAELESSAAYSCIANGQTCPSGIIPTSSLACGVAWDNYDRFVETQSGKNTLHDTVGIAYQDIPAANHLIAQESHNSSNVQEQNLALNLRNKSNRRKRSFESFETENLPPTKQKRPEFISNNKESASTNPTTTVSLESTNTDPPTSNEELFINEDNTQGVETSSTSDNEKCVLLFKQINFCWIFSHKLHLQNVPMWVGYNAKISNDNSTIQKIDYLTQINDSPTDPRVIKETMRLSLKIASECGKKYFNVTYDLAIAKIALKIQSAEEEFKNLFIHLGSFHIMLSFFKAVGKFINGCGLTNMLVDAEVLANGSINTFLTGKHFNRCCKIHPIISLALQLLHVEFFLENKQYDLETIKTYLKHYSENENENPVINNELCHKIFEDYAQFKKDTLQGNHGKTPQIFMMYIQLIDYYLMLEFSIRTANFDIYKYVLEKMTNIFFAFNHQNYARYLTIYLNKLEKIEETHPGLIQEYGDCFFGIRRTTKPFSRNPIDITLEQTINAHAASRSSGIINMTNSVGARQKWAITHSLRTNMISKLMDFCNLYSKDDITKDLRKSSICHSNKNVENLLTIIQQCTNPFSSNLSQENLYNISSGQSVSEDIYTFLSNIETTGELQRIKFITESQIDPERFDKAILKNTVVNFASKCVKKVKINGKVKEVTIQRDIFGRLFYASLQSHIDLKEALKYPLTPIPFSLCHSDGSICKTQKSVIFEELKSYQEENGNPPKADIHIYDGFYLLHTLKNVPNTYGKISMYIFKLLVSDKKEVHIIFDKFNDPSIKDYEHRQRGEDDTVHSVHKNNKRPSDFGKLLRSKNFKESFVEFLIDDWTDDCFVILCQDKIVKLSYGTSCYSYQVHENHIKKTTDYNLCCFHEEADTKIMYHICQLPNNYNVEVHCTDSDIPVIILANMKYLKADIQITVNMCSNKKREYLNMNKIYQGLGDKLARALTVCHIFTGNDFNPAFYRKGKKRPFAILKKKQSYQDAFMQLLETVPKYLDTEHEVFKSIEEYVCQIYSLNTKNDIDKGRFEVFERKYKNKNENDKIWRKNLKGFDASNLPPTKKELLQHIKRTIYISNVWCNAHLRRPTDLDIQECGWLNIDGSFEFFWFDGEQCPTFREIAAHSVSTSDDQDEGEPSSDESEDEQNLYLSEDSEFEDNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGU2</accession>
    <name>A0ABM5KGU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 9e2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509403.1">
        <property type="nucleotide sequence ID" value="XM_050653446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509405.1">
        <property type="nucleotide sequence ID" value="XM_050653448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509408.1">
        <property type="nucleotide sequence ID" value="XM_050653451.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509415.1">
        <property type="nucleotide sequence ID" value="XM_050653458.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509422.1">
        <property type="nucleotide sequence ID" value="XM_050653465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509431.1">
        <property type="nucleotide sequence ID" value="XM_050653474.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509440.1">
        <property type="nucleotide sequence ID" value="XM_050653483.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653446.1">
        <property type="protein sequence ID" value="XP_050509403.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653448.1">
        <property type="protein sequence ID" value="XP_050509405.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653451.1">
        <property type="protein sequence ID" value="XP_050509408.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653458.1">
        <property type="protein sequence ID" value="XP_050509415.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653465.1">
        <property type="protein sequence ID" value="XP_050509422.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653474.1">
        <property type="protein sequence ID" value="XP_050509431.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653483.1">
        <property type="protein sequence ID" value="XP_050509440.1"/>
        <property type="gene ID" value="LOC126886485"/>
    </dbReference>
    <dbReference type="GeneID" id="126886485"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60954" checksum="B4753871A5D0B728" modified="2025-10-08" version="1">MLQLVLIFTAVVLFYYFAIKPMSYWKDRGVVQSKPVWFFGDQWKQIFRLENIYEFFERGYKLTDGRYAGMYQFNIPTLIIKDPGLLKQIAVKDFDHFVNHRPLIPEGGDPLWSKNLFALTDQKWRDMRPVLSPSFTSSKMKMMYQLMADCAQNLVDHFSKINEEVAEVSFKDVSTRFANDIIATTAFGLHTDSLKNKDNEFYLMGKEITDFTSVSSVSRILGFLFIPRILKLFDVKLFSGASRNFFINLIDKTIKAREEQHIVRPDMIHLLLEAKKGNHHKDDHNVTDTGFAIVKDEHLGKAPTTVANEITNEDITAQALIFFFAGFDSVSSLMSFMSYELAVNPDVQTRLREEIDEGFQECNGKLNYETIMKMKYLDMVTSESLRKWPNFAGVDRVCNKEYVIEPEQPNEPRLVIEKGTILVFPIMSIQRDPKYYPNPDKFDPERFSDENKDTIDPYTFLPFGLGPRNCIGSRFAMLETKALFAYLLHSFEIVPTKNSTIPVVLSKKNFNLAAEDGMILGLKKIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHZ3</accession>
    <name>A0ABM5KHZ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050509810.1">
        <property type="nucleotide sequence ID" value="XM_050653853.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653853.1">
        <property type="protein sequence ID" value="XP_050509810.1"/>
        <property type="gene ID" value="LOC126886795"/>
    </dbReference>
    <dbReference type="GeneID" id="126886795"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25148" checksum="6A26FDE57D5F6CA5" modified="2025-10-08" version="1">MAHTYKLTYFDIQFIGRGEQIRLLLSYGGIPFEDIRIKHADWPKIKPTTPLGQVPVLHINDKSITQTGPICRYLANIVGLAGNNNEENLEIDVAAEMIGDVLKTAYEYRFETDETRKEKVKERLLELMPIIFTVLEENAIRNQGYIALDRVTFADIIFLCAYEDIRNILENTDVIADYPNLQEVKKNLLSIESLKDWIQKRPTLPIFIYDLKNDIASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJH3</accession>
    <name>A0ABM5KJH3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510359.1">
        <property type="nucleotide sequence ID" value="XM_050654402.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654402.1">
        <property type="protein sequence ID" value="XP_050510359.1"/>
        <property type="gene ID" value="LOC126887065"/>
    </dbReference>
    <dbReference type="GeneID" id="126887065"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="473" mass="55557" checksum="FD8D73011EB86483" modified="2025-10-08" version="1">MKNFPFLKHQELLVEVSDNNPVDFFRMLLTDECLQQVCDETNRYAEHIFLSNAGATHSRIFDWKILTSEELLVFLGLVLHMGHISLPRIEDYWKKKDPLFANAIFSTFMGRNRFMVIMRCLHFNNNPEEGEQVPEDRIYKIRLMINFFNKRMEEVYYPDRNLSLDESMVLHRGRLNFRQYLKNKKHKYGIKLYMLTEPNGLILKFLVYSGMFDDSGGKGHVNKVVLHLLEGKLNVGHCVYMDNFYNSFDLAKNLLEFSTYCTGTLRIDRKNNPAEVRQEKLAKGATIARCRKGVLVGKWKDKRDVYYITTECQNTLQEVTTRRGQHVIKPEPIIRYNKNMSGIDRQDQMLAYYPSQRKTVRWPTKIFIHVIQMMAINAHILYNKYSGKKIGLYEFRLQLVRSLLKVINSEAKLVPKDHSVTKREVKDVKGKVMRKRCKTCSQQNIRKDTIYECKACPDTPGFCLDCCQISHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJL4</accession>
    <name>A0ABM5KJL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510399.1">
        <property type="nucleotide sequence ID" value="XM_050654442.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654442.1">
        <property type="protein sequence ID" value="XP_050510399.1"/>
        <property type="gene ID" value="LOC126887104"/>
    </dbReference>
    <dbReference type="GeneID" id="126887104"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="331" mass="38455" checksum="87468C63A12764A5" modified="2025-10-08" version="1">MKILSSSRLFDQLFLVLKYHARVMSTFKFIDVSANLTHAQYSGCYGHPPTKIHKADLQQVLERSWEAGLQRIIISTRDLNESIKGLKIAQSDKRLFCMIGCDYANSLHFEEKGETDLYIQQVTDVISSGKEKVVAIGECGLNSCNKYYYPLDFQLKYFKIQLQMSKIFKLPFILSLCGNDIDKLMLNELSNYPELRGVIYIFSPTVQVMTRFVEAGFYIGLDTWSFKSEETIEAVKIIPLDKIIFQTNCPNRIILRSFPGYWYISRKNLDDLLTTKKEKWRPDFMVNERSEPCCIRQILDMTALVTNMNKHDLAEQVYQNTMRLFFPGENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJV4</accession>
    <name>A0ABM5KJV4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC43 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510393.1">
        <property type="nucleotide sequence ID" value="XM_050654436.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654436.1">
        <property type="protein sequence ID" value="XP_050510393.1"/>
        <property type="gene ID" value="LOC126887099"/>
    </dbReference>
    <dbReference type="GeneID" id="126887099"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058771">
        <property type="entry name" value="PWI_CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26091">
        <property type="entry name" value="PWI_CCDC43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC43 PWI-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="208" mass="24017" checksum="4EB927F64FD4BBDB" modified="2025-10-08" version="1">MAGAPEIEDFPSWLREKLKELNTDETVFGSYIQGILDSDDSEEEKNEAIQGLLTEILENESEIIKICNEILEHWERFKPQEACAKQMSSEDVNIKLAKLLESQSLATTKQKQYTAEEKKIREAILSQYSEMTDEEGEAEDVQAGGEDGGLEKNLNSHTVAQAEKLKREQARQDSQKKKEKDKEDREKQKQLKEDKKEKRKTVKGERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJW9</accession>
    <name>A0ABM5KJW9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510408.1">
        <property type="nucleotide sequence ID" value="XM_050654451.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654451.1">
        <property type="protein sequence ID" value="XP_050510408.1"/>
        <property type="gene ID" value="LOC126887109"/>
    </dbReference>
    <dbReference type="GeneID" id="126887109"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="36015" checksum="EE140F74DFEF6329" modified="2025-10-08" version="1">MSFRRTSSSLLKLFKNESLFSTYRFSSKTTGEYCLNYVKKYDYENFVCTLLLENSTRASALAVRSFNIEIAQVVENVSQETIGLMRLKFWEETVEKCLSTNYKLVPKHPVAQELFRANSIKKLSKRYLHNLINSRKTTLNILGFKSLEDMEKYTEQSVSNVYYLILESCGVKNIDADHAASHLGKAQGIVQHLRSVPHAARLNFLAIPDDILIKNKVSQEHIRRAKNSKELHECIFEIASRAHQHLMKARSLMEKVPQEGRKVLLPAVPVFIYLERLQKVDYNVFHPSLQHRSWKLLPQLWFTNFRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KK78</accession>
    <name>A0ABM5KK78_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510609.1">
        <property type="nucleotide sequence ID" value="XM_050654652.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654652.1">
        <property type="protein sequence ID" value="XP_050510609.1"/>
        <property type="gene ID" value="LOC126887245"/>
    </dbReference>
    <dbReference type="GeneID" id="126887245"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="224"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="693" mass="78932" checksum="1AF9CD8EDD85C28D" modified="2025-10-08" version="1">MFRKGLSEDELRRLAEESDFSDSSMSESTFYDSDADPVYNENVTDGSSDSYSSEYESRRKKAKICKQTQNCKEFTAGSSSNQKEADTRRIEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVVSRNKITWSDVPNPDDLNKFELSFTSGINQEELAKLTDHKPIDFYLLFIDRQVQDLLVTETNKYAEQTIIAGIVNESITKHSLMSNWRPIDRKELLRFLALIIWMGLDRKPKLRNYWSNNLLYKNEVSKMCEISRSRFEILLHFFHISDNESCPPGNRLYKISPLVQILNEKFQKMCTPRESLCIDETMVPFRGRLSFLQYIPGKRHKYGVKLFKLCVADGYTYAVKVYGGKEMQPSEKSLASRVVMELMQPLLDTGRSLYTDNFYTSVDLAHDLNNRKTHLVGTLRSNRKHNPKAVVNAKLKRGDMKYLQSNTKVVIGKWKDKRDVLFLTTKDIPLMIDVQTKRGPVPKPSTIVDYNSAKSFIDVSDQKAAYNSPVRRSMKWYRKLAVELLTNTALVNSLVLYKSVTGKHLSITEFREQIVQSLLMPQTTSENSLTTSENSLTTLHTLDEKEKRGRCSACYKNFSNREGRASAMKNAKRVYTFCPACAVNTAYMCVKCFVNIHTCSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQZ1</accession>
    <name>A0ABM5KQZ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512608.1">
        <property type="nucleotide sequence ID" value="XM_050656651.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656651.1">
        <property type="protein sequence ID" value="XP_050512608.1"/>
        <property type="gene ID" value="LOC126888407"/>
    </dbReference>
    <dbReference type="GeneID" id="126888407"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="387"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="587" mass="69313" checksum="1A3966291D6D38B7" modified="2025-10-08" version="1">MEVNVSLRTLLNINRGKKRKININQWRRNIRKRHRNAGEAYISVRNENVPEKPRPHEERLCKCKSVCKADKIQGQFGDLFTKFHSLDYNGQTAHLASCMELQEPQRRRVPEDISRRQCTVRYHILIGVKKLPVCQKTICQAFGITPRRIQHIQQKIKTDMPLRDQRGKHNNRPKKVHETDKERIKEHIKSFPHQENHYSRAASSKNCLPAELSLKKMYKLFCEKYPQCNVSRRTYTDIFQSDFNLRFGLPRSDTCTFCDKMYIKLVATSDGPERKAILVDSELHHARAEAGYKALKLDAEKANPQLVVLFTDLQQMLYCPTLTHSSVFYQRQYATYNYDIHDAGSNDATMMLWHESIGNRGSTDIASAFLCYIKHNFRPLNSGEIKKLIVWSDRCVGQNNNWRMLSMFRLLIVNRYFTQVEQKFLTNGHSFLPCDRDFLLIERKKKTAMVNVPFDWVVVIANSRPSKPFNVYYMEQKDFKDFSACENYLWKDPKCKITEYRWFKFDSDDPTRTMARTSHNIMQPWQTFSLVNKKWGAKAIRAFNYQIDALPNAYTGPIIIKEEKRKNLLDMCQYLKPEYREFYEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRR2</accession>
    <name>A0ABM5KRR2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512876.1">
        <property type="nucleotide sequence ID" value="XM_050656919.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656919.1">
        <property type="protein sequence ID" value="XP_050512876.1"/>
        <property type="gene ID" value="LOC126888570"/>
    </dbReference>
    <dbReference type="GeneID" id="126888570"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="62"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="287" mass="34025" checksum="AFC33642E9B688F7" modified="2025-10-08" version="1">MSETRKRGGEPELRFVQHPLIELEVDIPKEEKEEELTPENVDYEDDVEYLRSLDPKEWKSQDHYKVLGIPNIRYKATDDIIKTAYRKKVLKQHPDKRKALGEEIKTDDDYFTCITMVYETLGNISRRRAYDSVDPQFDNDLPCTSDIKKDFDKAFTYYFDLSFRWYEKTRVPKLGTENSTKEEVEHFYSFWYDFKSWREYSYDDEEDKDKCQDRDERRPYGKGHENGPSLKSTVVSAGQDSLSHCQRVSWNTVRSFLELTLTRTNAIRCVHIENVEGVTVCHFGIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRT7</accession>
    <name>A0ABM5KRT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512898.1">
        <property type="nucleotide sequence ID" value="XM_050656941.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656941.1">
        <property type="protein sequence ID" value="XP_050512898.1"/>
        <property type="gene ID" value="LOC126888589"/>
    </dbReference>
    <dbReference type="GeneID" id="126888589"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="66494" checksum="DD3976A314F49137" modified="2025-10-08" version="1">MEHLKTLRVKRGSLEARLANFQIYVEKCMTQIDSIDDRVLKNRLSDIESLLAEFSELQVGIECSVKEEDLQGEYDKRKAFENDFYSIISKAQGLAKENSTDNVGSALVSNPENSRFPSSSEVRLPALNLPIYSGEAGEWLQFRDSFDSLINSNLSISNVQKFHYLKNALKGEAFEVIANIQVTHDNFPIAWDLLCDQYTDKRALLHVHTKALFDIHPVKKESSKSLSHLVDHVRMHLRSLKSLGQPTESWDTLIIYLVFTKLDPVTIREWESKDFMNDTPKLEAFLTFLKQKSKMLKRMEENPTEANSSQNVKGQTSKPPAESSNRSNSHVQRSYHISNRTCASCDAPNHKIYTCTKFLRLSVPERTDLVEKSNLCVNCLNRGHQVNNCNFGHCKNCTVKHHSLLHVSEPSTSNTNTQQSLFTFNLSSKQVLLSTVLLEVVDSKGNRHDCRALLDPGSQSNFISSHLCHKLALPRKPTNITISGAFKVESKIQAVCQIQIVSKNTPFTASLVCLVAPEICDVVPEAPIDPLFSKYRTFQASATVFLDDEHINTGGIYFQHDGASPYYRRIVRDFYSTIFPIDGLVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRX5</accession>
    <name>A0ABM5KRX5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512941.1">
        <property type="nucleotide sequence ID" value="XM_050656984.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656984.1">
        <property type="protein sequence ID" value="XP_050512941.1"/>
        <property type="gene ID" value="LOC126888628"/>
    </dbReference>
    <dbReference type="GeneID" id="126888628"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF161">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16928" checksum="9C67B17E59D73FEC" modified="2025-10-08" version="1">MGVICSLNDRCTEGSNDLKSIMKLHNDEKSYKCEFCTKEFTKKSDLNIHGRLHKNPYRCEICYKEFRQKASVKRHLPIHTGKKPFKCDICSKEVTTRSHLKRHLRIHTGEKPFECESCSKSFFDKKNLKEHLIRHTGERHFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVW4</accession>
    <name>A0ABM5KVW4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514328.1">
        <property type="nucleotide sequence ID" value="XM_050658371.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658371.1">
        <property type="protein sequence ID" value="XP_050514328.1"/>
        <property type="gene ID" value="LOC126889782"/>
    </dbReference>
    <dbReference type="GeneID" id="126889782"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF46">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1428"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1497"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1862"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1938"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1979"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1862"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1882"/>
            <end position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2001" mass="208602" checksum="5BB225B341E7C830" modified="2025-10-08" version="1">MLKTCPDPVDINDIQFKLHCSLKIFDNSSIETFQNNNSLISCASRYGLLFAGSNSPSLKVIQVKTVENFTHKDKEISQFPRRTIPLPSPAKHVSVNCDSTLLAVVIQRDNCPVVIFYDVLSFYKQNVVVVKEVRLSATPGTFITEVGWNPAIPGIFTACKNDKILGVYELKGSSVEINELPAAAGSVSFSWSPKGKQIAVGSITGTIVQYKPDLKAVRKIEAPPFETAPSLISLCWVSNFQFIGVYQFPEDAKLIVVDAPKTGETNYTNYDDVCYSGSTRISQFYLILLQHWNLLMIASSNSMELGLLGLVSEIWTQWNVPDFARAELPLGSDKQETLPVGMALDISNTKPLPWGEGLKPPCPYLLLLSHTGVLYFYNLVNLKEGIPSINSPPDAIADSSGLAQFVLETQQAEVAATPPKPQQPFSFGNVAQPVAVAQPLITPAPAKVIPQTSQPSFDIIKPIVTQPTPPFGLPQGSVPPGQSLFDKSLGPQVTITPVKQQPQISAPSIFGGAVTLTPVKSQPQNVETSEKYSAIYSALKAPSMIPAPADPRPILIATKQEGQPVGAHPVLPDPRSVPMPELVALEPIKFPTAEAPRIIVTPKTAKNVPHDVPKTTMPQIQKTDVDPKLAIDEQVKGETQAILTKMVKEECLALESELKALLHQGRKINVNIGNENEKIMMIKELQDLQEFVKEIVDVSLGESAEVHSLKQNLVLSWAWYEEALSRYNLSKDETMGLILKSQPLDSATEKRQSDIKKMMYYLDSQLSQASKALDEQWDNFQDYTKKSYRVQMPTMEAIFQTMVRQGALLQKQNYILKDISSNANLKQMSKDTSSLFVGLKKIEDLKYLRLDPDDDYRILHEQIRDRNKKLTSSKTQKLRDFLKHRDITHVTAARPKLNTSLTRSPTVRGSHVFSILGAEMSPVMKPAVVKNLKFSESTPLKLMQDIKPTLVPPNTPAQPEPSKTFTFKSLDKNVLPPNVSTYYPVTKNLLSNLTQTPISSAFVPTTQATKNFTSSAGLTFTTPSTVAVEGTPSQTSVAQSLYPNLSQYTFDSTSTSTKPESSVPSQGKVTFSFKSNVDVSSELPSQNTGAQSFFSFGKPASSAIATASLQTVATTTSSKSLLGTPGTADTGSLLTAPKPNFFSTAPLTILQSTTSTSAQLPQTTSVSNVSKPSTPLMNLNTASVALTTTTTSLFGSISSPSVSTSFFGTKPLTSSAKVASFGDVKSTGDGDRLHSTTDEATISSTIATSTTSIGALKTPSSSSGSISVTKSGFTPVVSSTSMFAPGTAISTKVGSLFSSIPPATSIKSTFNTSTSASVFPTISSSSSGISISSKSSIFDKTESTQGSVFTSTATVTESSIFGNTGSTAQTTLFASQPTVQSSSEFGTPVITQTSTVETPKSTQASVFGTAATQPSIFASPATTQSSIFSPASTQPSLFSTPTTTKSSIFTSEAPTQSSPFSNTAITQPSIFASPTSTSTTTQSTIFASVATTQPSIFSTPTTTQSSGFGTPTTTPGTIFGATTSTATSTFGMPTATSSAFGASSASPLAGFGAPSITAPAATSSSTFGASSTSPLAGFGAPSLTAPAAFGSQNTTQSSIFGVTTTTKSSIFGSPSTTQSSVFGTPSTTTQAPFFATTQSSVFGGQSTGSIFSSTTPSAFGSASPTSTQGSIFGAASPVSSSSSIFGAPATTSSGFGQTTGSIFGSSGFGATATTTAAFSQPATFGSNSGSIFGTPATSNNSVFGSGSNSFGAASTSSSVFGSTPSSSFSFASAANNAGSLGFGNLNVGNTSGNSIFGAAPTFNQPNANPFASATNIETPSTTGSIFGSGSTSSGFGSGGGSSSQSIFATNTFGSAGGFGQQSSFGQSTFGQQSFGSPQAGPFSGGGVGVGQTGFGSPGGFQKQQGGFGGAPVFGGSPQAAFGSSPSFASPPAFGGAPSFGSPAKVFGSNAPPANFGNAGAASPGFGNLASQNTVGFGSLAQQASSSPSTPFSGSSSFSSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVW5</accession>
    <name>A0ABM5KVW5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514329.1">
        <property type="nucleotide sequence ID" value="XM_050658372.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658372.1">
        <property type="protein sequence ID" value="XP_050514329.1"/>
        <property type="gene ID" value="LOC126889783"/>
    </dbReference>
    <dbReference type="GeneID" id="126889783"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="417" mass="46745" checksum="CB02FEF6C0C95007" modified="2025-10-08" version="1">MQGSSEGQLQIRLITKQDIYAVPDLPLSVPQAINANSLNELLNQLLKESNSDFLKPKDFDFLAIGELIRQPLIDHLQERNVSTETTVDVEYLERTPAPEPKDSLLHDDWVCGIETSDKWILTGCYDNSVNIWSTHGKIITSLKEHRNVVKAVSWIDKTDPSKGFISVSHDLTGLMWSFEPGTDNVVPQAVLRGHERGIDSVGVSPNSSRIATGGWDTNLKLWSTSIEEERSEPLQKRSKSSNNLVTKTPLNTLKGHKETISAVNWIDNYVVSTVSMDHTIKFWDAELCGIKNEIVGQKAYLSSSWSPLSNTLLASSADRHIRLYDPRSTEGSLCKTTFTSHTLWVSSVIWSNYDQHLLLSGGYDSAVKMWDTRSPKAPLYNLQGHQGQVLKVDWSNRKYMVSGGSDNSVHIFKNKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYX5</accession>
    <name>A0ABM5KYX5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adult-specific cuticular protein ACP-20-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515387.1">
        <property type="nucleotide sequence ID" value="XM_050659430.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659430.1">
        <property type="protein sequence ID" value="XP_050515387.1"/>
        <property type="gene ID" value="LOC126890466"/>
    </dbReference>
    <dbReference type="GeneID" id="126890466"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046177184" description="Adult-specific cuticular protein ACP-20-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11861" checksum="CBE5C6B1101E14D6" modified="2025-10-08" version="1">MIAQVLFISTIVAIAQAGLLHGGLDLGGSSYAGSHSIVVAKEPVVEYYAPPKYEFKYGVQDWHTGDVKNQEESRVGDLTQSDYSLAEKDRKVSVSRIIAGAVPISHGKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1F4</accession>
    <name>A0ABM5L1F4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516264.1">
        <property type="nucleotide sequence ID" value="XM_050660307.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660307.1">
        <property type="protein sequence ID" value="XP_050516264.1"/>
        <property type="gene ID" value="LOC126891126"/>
    </dbReference>
    <dbReference type="GeneID" id="126891126"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="42206" checksum="E9F6E3705DB5CCF8" modified="2025-10-08" version="1">MTRLKVLIDSGGSDTVISPKASKFFNPSHIYEKPFTLTSLNPEGLDDILFYFNSCDTYIQFTIEKEDGAYSVPFLDTRVIREPISNKLKIDWKKVFGKQQVLIPATDISEKESTHTAAVSPKTYSDLQTVREVEFNLKLPDIIYEEGSNSDGYSNKENEIGDVRVMDDNQNQEEDRQSGRKEYRQDLNFVNRDINEDNNIVEMEQSDKGENDGEKNGVKSKEKKYQGRPKKGRKRKFPSQNREIRKKHCIQNKSYFTQKGEMKLKKEFRQYLCKCDCLSKVGIENAKQEYDKFYEVSSHDAQRALICAMVQEGPIKRKRKQNSTKKMHSRVYNINGHVVCKTFLLQTLRISSAKVDNALKSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L229</accession>
    <name>A0ABM5L229_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516493.1">
        <property type="nucleotide sequence ID" value="XM_050660536.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660536.1">
        <property type="protein sequence ID" value="XP_050516493.1"/>
        <property type="gene ID" value="LOC126891360"/>
    </dbReference>
    <dbReference type="GeneID" id="126891360"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="169"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="428" mass="49873" checksum="29A1D1F7201B5443" modified="2025-10-08" version="1">MNWEFVNKDLHIQAQRIIINIYSCLRDENSTLSETNIVIRICELTKIARSTVLRVIAAGDVIDHSVKRQRVGQNLKKIDKATRDVICRFVYEFYQDNKVPTLEMLQAKLKICPDYPYKSLDTLRRALIECGFNYKKLDKRMVIMESTRIVIQRQHYLRKIKEYRDDNRDIVYLDETWFDTHDVVQYGWMDGSKKCCLSTPCSRGKRILILHVGTKDGFVPNALLLSSKNIKQSSADYHEDMTAELFEKWATEQLLPNIKTNSVIVMDNAPYHSRLYTKIPNTSSKKGDIIEFMENKGMTIPSKCTKKELLQLIKQQNLKKEYAVDKLFERHGHMVLRLPPYHCVFNPTEMVWADVKNKLRKMNQSPQLSDVVVQNIRTVIEDLNKTNIWKNCVAHVQVKENEYVTLPPIQPIVINPNDDSSSEQTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L250</accession>
    <name>A0ABM5L250_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516519.1">
        <property type="nucleotide sequence ID" value="XM_050660562.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660562.1">
        <property type="protein sequence ID" value="XP_050516519.1"/>
        <property type="gene ID" value="LOC126891386"/>
    </dbReference>
    <dbReference type="GeneID" id="126891386"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF33">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47584" checksum="1CA2B915F9C304D7" modified="2025-10-08" version="1">MSSYKHKSGALKRKLQKEKLEQSAKGRQDIKKFFKSNEKEELQEFQPDFNPEPTSASQTQPSSASIQNASTSTVCEGSNDECASADPNLSKDTVDDNKTFNFDDPNTWPAVMSDKIRQEIVLCYGGFQAFQARSKSFPADPSGKHFHETLLYMKTDNRTCKAIPREWLMWSETKNSIHCLPCSIFHSNQNKSKLAKEGFFPEKQQYKRLYRLFSMHERSSEHRKHYLEWKSLQISLKGHGVDSNLQQIINCEATRWKAILQRILDTTIFLSSRGLAFQGENTQIGDVHNGNFLGVLELIGKYDEVTREHLAKVKENQLNKKSFRQVFCFPKNILRTADLDKHKKFIWYGTEYRICRIAHPMDNHKPNFECDVCVESCDKNPSHYYFTEKTVSYTVETFLSHYNQSLILPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5R1</accession>
    <name>A0ABM5L5R1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517776.1">
        <property type="nucleotide sequence ID" value="XM_050661819.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661819.1">
        <property type="protein sequence ID" value="XP_050517776.1"/>
        <property type="gene ID" value="LOC126892321"/>
    </dbReference>
    <dbReference type="GeneID" id="126892321"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="600" mass="70645" checksum="88A0A3FFFC374FA3" modified="2025-10-08" version="1">MEFKVEIKGEFFENNERSIGSPLFTSTGIGGLKNEPEAMELKADIKKELVEDEQGYIESQLTSSVDLGDLKNEIDEDSSGFSKENGMEIMNTLPEISCKEVQQISPSSGEKKQLSQKDCLECDTYNCEICFKQFKHKSHLKTHLRLHSGETPYKCEICFKQFNQASNFKAHLRLHSGETPYKCEICFKQFRHKISLDAHTTVHTGETLYKCEICFKQFNQKINLKTHLRVHSGETPYKCEICFKQFKHKSNLKTHLRLHSEETPYKCENCFKQFRHKISLDAHTTVHTGEMPYKCDICFKQFNQKSNLKTHLKLHSGEMPYNCEICFKQFNQKINLKTHLRLHSGETPYKCEICFKQFRQKISLDAHTTVHTGETPYKCEICFKQFNQKSNLKTHLRVHSGETPYKCEICFKQFRQKISLDAHTTVHTGETPYKCEICFKQFNYKSNLKKHLRLHSGETPYKCEICFKQFNQKSNLKIHLRLHSEETPYKCENCFKQFRHKISLDSHTTVHTREMPYKCEICFKQFSESGTLKRHLRVHTGEKPYKCEICFKQFNQESNLKRHLRLHSRETPNKCEICFKQFSRKDVLKTHLRVHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L633</accession>
    <name>A0ABM5L633_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517902.1">
        <property type="nucleotide sequence ID" value="XM_050661945.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661945.1">
        <property type="protein sequence ID" value="XP_050517902.1"/>
        <property type="gene ID" value="LOC126892416"/>
    </dbReference>
    <dbReference type="GeneID" id="126892416"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="128" mass="15806" checksum="5DD5A3D700593F8C" modified="2025-10-08" version="1">MERYGVQTVKYSFVFVKHLWIGMKIVYQTCSVMKPYLTLKAFDDPLIPYTVRGHKRIKHSLVTNEEFTYTDQYGSLIWEWNPYHSQHLVWARYNDAVTREYWRRVRKHLNYNLELYKFYRILKIVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZ85</accession>
    <name>A0A6P7EZ85_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114324636</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114324636</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128306.1">
        <property type="nucleotide sequence ID" value="XM_028272505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZ85"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272505.2">
        <property type="protein sequence ID" value="XP_028128306.1"/>
        <property type="gene ID" value="LOC114324636"/>
    </dbReference>
    <dbReference type="GeneID" id="114324636"/>
    <dbReference type="KEGG" id="dvv:114324636"/>
    <dbReference type="InParanoid" id="A0A6P7EZ85"/>
    <dbReference type="OrthoDB" id="6738542at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028128306.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23560" checksum="4E4EB3708BFBCA90" modified="2020-12-02" version="1">MNRSWNRNSSSSSGFVYFAKESQKECGDSENFLSFQESPQKSYNHISPNYGTPMSHSSPRNFNKRNNYRYSGRNRGNRSYVSPNVNFKSWNNYNSPKPHHQKKISFNKIPMMSADGQRDMSMFYDHTCTWNPWADLEKHFKEEEPVKEEKMIESPSVPIVSEPESKTIIDTKKENESSSSDDSSDSDEDTSSSDSDKKEENDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZZ5</accession>
    <name>A0A6P7EZZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nuclear receptor subfamily 2 group C member 1-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114325133</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128879.1">
        <property type="nucleotide sequence ID" value="XM_028273078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZZ5"/>
    <dbReference type="FunCoup" id="A0A6P7EZZ5">
        <property type="interactions" value="2307"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273078.2">
        <property type="protein sequence ID" value="XP_028128879.1"/>
        <property type="gene ID" value="LOC114325133"/>
    </dbReference>
    <dbReference type="GeneID" id="114325133"/>
    <dbReference type="KEGG" id="dvv:114325133"/>
    <dbReference type="InParanoid" id="A0A6P7EZZ5"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06952">
        <property type="entry name" value="NR_LBD_TR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000041">
        <property type="entry name" value="Nuclear hormone receptor HR78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000015">
        <property type="entry name" value="Nuclear receptor subfamily 2, group C, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048246">
        <property type="entry name" value="NR2C1/2-like_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="221"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028128879.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="54871" checksum="E3923C997831CBCC" modified="2020-12-02" version="1">MDMEPTIKTEMLGDKNRNNSNICLTVELCVVCGDRASGRHYGAISCEGCKGFFKRSIRKQLGYQCRGNQNCEVTKHHRNRCQYCRLQKCLACGMRSDSVQHERKPVIDKKEFPSNNDIKFNQSTVNVVKKIFIRKDLNSEYGLLPPFCPSDLGLQFLNQGIANSSATPESFHLSPSHASMEDDVSMDSAHTGTELNDALTTARDKQLISKALDTMARVQCLNGTNINALTNEEKCFDYDGPILQEQNMAFNLLIPGPVPPYLNIHYICESGSRLLFLSIHWAKNIPAFQYLSSETQIALLKNCWAELFTLGLAQTSQSLSLPTILSALISHLHASIARDKMSAVKVKQVTDHIVKLQDFVTSMNRLHVNEKEYAFLKALTLFSSDQPDMLMKKPIERLQEKSFQGLRHYLATNFPEDTDRFPRLLLCLPPLRAVESNIIEELFFASLIGQVQIDSVIPYILRIGNSVSASSNNRAVKTEHLDEFLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F025</accession>
    <name>A0A6P7F025_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="14">ITPase</shortName>
            <shortName evidence="14">Inosine triphosphatase</shortName>
            <ecNumber evidence="14">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="14">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114325155</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028128914.1">
        <property type="nucleotide sequence ID" value="XM_028273113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F025"/>
    <dbReference type="FunCoup" id="A0A6P7F025">
        <property type="interactions" value="1483"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273113.1">
        <property type="protein sequence ID" value="XP_028128914.1"/>
        <property type="gene ID" value="LOC114325155"/>
    </dbReference>
    <dbReference type="GeneID" id="114325155"/>
    <dbReference type="KEGG" id="dvv:114325155"/>
    <dbReference type="InParanoid" id="A0A6P7F025"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028128914.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21541" checksum="264AD8501544FDAF" modified="2020-12-02" version="1">MSKAITFVTGNSKKLEEVIQILGSDFPRKLVSKKLDLPELQGDINEISILKAKEAYRQISGPVIVEDTALCFNALKGLPGPYVKWFLEKLGPEGLHQMLFGFEDKSAEAVCTFAYHPGGENDKVILFQGKTAGTIVSPKGPRDFGWDPCFQPDGYDITYAEMLKTEKNKISHRFKGLDMLRDYFIKESVEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2R9</accession>
    <name>A0A6P7F2R9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Splicing factor 3B subunit 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114324527</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128188.1">
        <property type="nucleotide sequence ID" value="XM_028272387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2R9"/>
    <dbReference type="FunCoup" id="A0A6P7F2R9">
        <property type="interactions" value="2546"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272387.2">
        <property type="protein sequence ID" value="XP_028128188.1"/>
        <property type="gene ID" value="LOC114324527"/>
    </dbReference>
    <dbReference type="GeneID" id="114324527"/>
    <dbReference type="KEGG" id="dvv:114324527"/>
    <dbReference type="CTD" id="23450"/>
    <dbReference type="InParanoid" id="A0A6P7F2R9"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000027">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000041">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="14"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="445"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028128188.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136630" checksum="5E86DC9508DA1A4C" modified="2020-12-02" version="1">MFLYNLTLQRGTTISHAIHGNFSGSKIQEIVISRGKILELLRPDPNTGKVHTLLTIEIFGIIRSLMPFRLTGGTKDYVIVGSDSGRLVILEYNQQKNVFEKVHQETFGKSGGRRIVPGQYLATDLRGRAVMIGAIEKQKLAYILNRDAQARLTISSPLEAHKSNTLVYHMVGVDVGYDNPIFACLEIDYEEADSDPTGEAAQKTQQTLTFYEIDLVVNHVVRKYSEPLEEHANFLVTVPGGDDGPSGVLICSENYLTYKNLGEQHDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDDDMVTEIKLKYFDTVPVATAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDDELEFSSAMPLEEGDTFFFAPRPLRNLVLVDELESLSPILSSRVADLAGEDTPQLYMLCGRGPRSSMRVLRHGLEVSEMAVSELPGNPNAVWTVKRRSDDDFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTAPTLCCSALSDDALVQVYPDGIRHICADKRVNEWKAGKKSIVKCAVNQRQVVIALSGGELVYFEMDHTGQLDEFKERKRMNSDVLCMALANVPPGEQRSWFLAVGLADGTVRIISLDPSDRLAPRAMQPLPVCAESLCIVEMGCTERDPDNAAAASTTSTLYLNIGLQNGTLLRTVLDPVTGDLTDTRTRYLGSRPVKLFRIRMQQSEAVLAMSSRSWLSYYYQNRFYLTPLSYESLEYASGFSSEQCPEGIVAISTNTLRILALEKLGAVFNQVSFPLEYTPRKFLIHPESSNLMILETEHNAYTEETKKQRRLQMAEEMREAAGEDEQELAKEMAEAFLNEDLPESIFSAPKAGHGMWASTLRVMDPVQGTTYNLIRLEQNEAAMSLALLKFHGQPEHQWFLILGIAKDLQLIPRQCNMGYLDTYKVDPSGKEFELIHRTLVDEVPNALCGYNGRLLVGVGKMLRLYDLGKKKLLRKCENKHIPNTIVNIQAIGKRIFVSDVQESVFMVRYKRAENQLIIFADDTHPRWITCTSVLDYDTIATADKFGNIAILRLPSNVSDDVEEDPTGHKALWDRGLLNGASQKADTITAFHIGETVTWLQKATLIPGGHESLIYTTLSGTVGALVPFTSHEDHEFFQHLEMHMRSENPPLCGRDHLSFRSYYFPVKNVIDGDMCEQYNSMEPTKQKFVASELDRTPAEVSKKLEDIRTRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F763</accession>
    <name>A0A6P7F763_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L23, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114325639</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129553.1">
        <property type="nucleotide sequence ID" value="XM_028273752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F763"/>
    <dbReference type="FunCoup" id="A0A6P7F763">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273752.2">
        <property type="protein sequence ID" value="XP_028129553.1"/>
        <property type="gene ID" value="LOC114325639"/>
    </dbReference>
    <dbReference type="GeneID" id="114325639"/>
    <dbReference type="KEGG" id="dvv:114325639"/>
    <dbReference type="CTD" id="6150"/>
    <dbReference type="InParanoid" id="A0A6P7F763"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000284">
        <property type="entry name" value="39S ribosomal protein L23, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028129553.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17903" checksum="63A0F79533843BCE" modified="2020-12-02" version="1">MSTRWYPIYQKGGPQLRVFLPNFWMKLVRPPHAQPANIVTFSCSMEMTKHDIKNYLEKIYEVKCADVHTRIHMPKTRREKTHGYVVKDDDIKYAYVSLPKGQEFKFPDLFEGGADKEMEDHKKALKQAKEGYQDFVDKNKERQNMPGWFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8S1</accession>
    <name>A0A6P7F8S1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114327490</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
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<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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            <taxon>Hexapoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
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            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="STRAIGHTJACKET, ISOFORM C"/>
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        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
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    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
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            <end position="21"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028133114.1"/>
        </source>
    </evidence>
    <sequence length="1343" mass="155822" checksum="94D287D7197B53D2" modified="2020-12-02" version="1">MFFHKNFIVIVFLCIWSLGCGDENILERNRENTAKQHPELSKLVKNWATKLGGELWHFGDLVTRQNRVRDSFKETNLVVEDGEALLQTIHENISHMMKQKVDAVRRIMDQAEQIAQAQKETDIDFNFPFFNAKNLTNSLDNTTEETTKEPEPEELQDDSFISSRYQDQQDQPYSQPLLQQEDFDGYQRDEDTESSEEPSSKDEDLLDADLEVTDNTEKDPQAILNKAPIDKSKLPLIRNRNFYDIPVNMNVSAVHVPSNVYERAKEVIAGIKWSEELDKTFKSNYEVDPTLSWQYFGSSTGFMRQYPAMIWSQEPIDLFDCRTRSWYIEAASSPKDVVILVDRSGSMTGMRREIARHVVHNVLDTLGNNDYVNIYTFSNTTEPLVECFEGQLVQANLANVRVLKESMTNFKTEQIANFSLALVTAFELLEEYRLNKKSARCNQAIMLVTDGVQYNYKEIFEKYNWENLPFMNVRVFTYLIGREVSDVREVKWMACANQGYYVHLSTYAEVREEVLNYIPVMARPMVLNPTQKPNPTWSPVYADVTDPKLTNWLWVNRERNRQRERFMGYRKLKHLLSAAHLDRTFVHQQKLHQDNYGDTQVYHLMTSVSLPVYDKKPRQNITENIQINEAIWIEVTREERVANLLGVAGTDIPIEYIQRLMIPYRLGVNGYAFIVTNNGYVLTHPDLRPVYQGILKPAYNRVDMIEIEIINDDSDARNFSDKIRDFRRHVVMQNTGNITLDVKSHLDDMRRITFMTRDYFYRGINGTPFSLVISLPKKYGYARVEPKVENDIHRLTLSQPPDKKPLLRYFAGNWTIHPDWHYCRYRDNKKHFDNPEEELVFFLQMMERHGWKWSKESECDRKLVCQVVSDAKLTDWFNDNITTTSREENGDGGKDGYEFKEILDFFELCKCCKCSCNNSFTCRAELVKKIGIVVAFMATHSGLTRWQNFPQNIESPEQEPNFHILHNKAIDEVWYRRAVEHHYVDPQDFIYSVPHYTGNSSLSLVTVSRAIFKEEQGKKAPVAVVGYQFFHGALQSLFTQITSNCGTIPCTRTCSSQELHCLVLDDNGYVVVSDNPKETGYFFGKIMPDVMNQLIDEKIYKVTTMYDYQGLCAEGQETESPASRLLSPIVHIANLFSYLAGYLIFLTKSILGSQIEAYPSEHFQETHFEVMDEHEYAAHNHENDQYEESEMPLSDKEFVQKFALQMTKPEPCDTQMALYSLIHYSDRDIAGSAYNRTMVECSRPYIVQKISGSNMILLVVNNVCSGEPKTTIDTPDPIEVDYNMSLACYRAMYNDFPRRHYMSCINRNANESEIKICGEGSYISPTKIVPMLLFTILSYILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCE1</accession>
    <name>A0A6P7FCE1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114328865</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133634.1">
        <property type="nucleotide sequence ID" value="XM_028277833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCE1"/>
    <dbReference type="FunCoup" id="A0A6P7FCE1">
        <property type="interactions" value="1421"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277833.2">
        <property type="protein sequence ID" value="XP_028133634.1"/>
        <property type="gene ID" value="LOC114328865"/>
    </dbReference>
    <dbReference type="GeneID" id="114328865"/>
    <dbReference type="KEGG" id="dvv:114328865"/>
    <dbReference type="CTD" id="42641"/>
    <dbReference type="InParanoid" id="A0A6P7FCE1"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000018">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028133634.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45316" checksum="0C38112FB1F64352" modified="2020-12-02" version="1">MPIENLEDQGLEKNPDLELAHCKFLLTLPEYRSDKNVHSKITEAIKKDDMAPWYELICKDAGWKLDANLLSALKAKNAEKIKLLDEAIEDAEKNLGEMEVREAYLRKAEYYSRIGDKDNAVSTFRQTYDKTVSLGHRLDIIFHLIRIGLFFMDHDLITRNIEKAKTLIEEGGDWDRRNRLKVYQGAYCMSVRDFKSAANLFLDTVSTFTSYELMDYKAFVRYTVYTSIISLPRNQLRDKVVKGSEILEVLHSEPFVKDYLFSLYNCQYAEFFTNLAEVETVLRKDYFLNPHYRFYVREMKILAYTQLLESYRSLTLQYMAEAFGVTVEYIDKELSTFIAAGRLHCKIDRVGGIVETNRPDLKNAQFNSVVKQGDLLLNRVQKLSRVINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCE9</accession>
    <name>A0A6P7FCE9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114327974</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028132502.1">
        <property type="nucleotide sequence ID" value="XM_028276701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCE9"/>
    <dbReference type="FunCoup" id="A0A6P7FCE9">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276701.2">
        <property type="protein sequence ID" value="XP_028132502.1"/>
        <property type="gene ID" value="LOC114327974"/>
    </dbReference>
    <dbReference type="GeneID" id="114327974"/>
    <dbReference type="KEGG" id="dvv:114327974"/>
    <dbReference type="InParanoid" id="A0A6P7FCE9"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="424"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="567"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028132502.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="74836" checksum="DA0534CF71B5BE33" modified="2020-12-02" version="1">MCALVADVLPTLYEYYTGGGIQTGLNADKPYFTLNNKNISIYSGAVHYFRIPKRYWRNRLRKLRAAGFNAVETYVPWNLHEPQPGWYDFGAGGSDMQEFLNVTEFLKIAQEEDLLAIVRPGPYICSEWEFGGFPSWFLREKNLKIRTSEPTYMKYVTRYFNVLLPILAMLQFTKGGPVIAFQVENEYGSTERTGRFVPDRQYLRELRTLFLNNGIVELLVTSDSPSQHGDIGTLPGVFLQTANFNFQTMIEFGALQKLQPNRPVMAMEFWAGWFDHWSEEHHVTNRNEYTTVVEQILKYPASVNFYMFEGGTNFGFMNGGNQDNDATDNSGYQPDTTSYDYDALLTENGDYTVKYVITKDLLKKYNKILTRIPQTPTETAKIAYNATPIQSQILLSELLERQETKIISPFVLPMEHLPINNNSGQSYGYIVYRKRFIDIPANSSLLVSGRVCDTLVVLINGNLVSKPLNKVSDLDSFGFWRVKDKSLPLGPNHYAEAVLDLVVENWGRSGFGAVDQFNQFKGLWQGDVYLNNKRIDDWEIFPLEFKKSWNQNLSGWHKPSKIWSVGPALYKANINIEKPADTYLDMSKWCKGIAIVNNFVLGRYSKIGPQQALYLPAPFLKQGNNEIVVFEHYNPAEEISFSSAQIYKTRTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDI8</accession>
    <name>A0A6P7FDI8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD, quinone]-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329239</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134084.1">
        <property type="nucleotide sequence ID" value="XM_028278283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDI8"/>
    <dbReference type="FunCoup" id="A0A6P7FDI8">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278283.2">
        <property type="protein sequence ID" value="XP_028134084.1"/>
        <property type="gene ID" value="LOC114329239"/>
    </dbReference>
    <dbReference type="GeneID" id="114329239"/>
    <dbReference type="KEGG" id="dvv:114329239"/>
    <dbReference type="InParanoid" id="A0A6P7FDI8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF154">
        <property type="entry name" value="FI04917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134084.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="73287" checksum="FE440624E0CE98F6" modified="2020-12-02" version="1">MTIIALSTILTAIKAGVAIVGVGKIAALPFLIAAITYFHYDQFDPENKNTDQKTLHASYDFIIVGAGSAGSVLANRLSEISNWNVLLMEAGGQETDISDVPIMSLYLHKSKLDWGYKTEPQATACQAMIENRCSWTRGKVLGGSSVLNTMLYIRGNRRDFDRWADYGNYGWSYEEILPYFKKSQDQRNPYLAKNTRYHSVGGYQTVQDNPYNTPLGIAFLEAGQEMGYDIRDINGEKQTGFALYQFTMRRAARCSTAKAFLRPIRLRKNLHICMYSHVTRVLIDPDTRRAYGVEYIKNGQKQTVLAKKEVILSAGALNSPQLLMLSGVGPKEHLEEKGIPVIHDSPGVGENLQDHIASVVTFLIDYPISLVINRLVNINTALRYAIKEDGPLTSSVGLETVGFIPTKYANQSDDWPDMEFMLTSTTTPADGGTQVKKAHGLTDEFYNEVYGMVNYKDTFGVFAMMLRPKSRGRIRLRSKDPLDYPLFYHNYLTHPHDVNVLREGTKAAVAFGQTEAMKRFGARYHNVPVPKCKHLPPYTDEYWDCYIRQYTLSIYHYSCTAKMGPPSDPYAVVDPELRVYGVSGLRVIDASIMPFITNGNINAPVIMIGEKGADLIKYYWLNPTTKRRKRSMDVAYTIKRDININQNCSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFK3</accession>
    <name>A0A6P7FFK3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114328906</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028133687.1">
        <property type="nucleotide sequence ID" value="XM_028277886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFK3"/>
    <dbReference type="FunCoup" id="A0A6P7FFK3">
        <property type="interactions" value="1955"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277886.2">
        <property type="protein sequence ID" value="XP_028133687.1"/>
        <property type="gene ID" value="LOC114328906"/>
    </dbReference>
    <dbReference type="GeneID" id="114328906"/>
    <dbReference type="KEGG" id="dvv:114328906"/>
    <dbReference type="CTD" id="51611"/>
    <dbReference type="InParanoid" id="A0A6P7FFK3"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028133687.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30737" checksum="998CC83257D07D55" modified="2020-12-02" version="1">MFYIIGLGLGDPKDITVKGLEIVKKCDRVYLEAYTSILTCGKEELEKFYGRPLIVADRDLVELGADDILAGAEEKDVALLVVGDPFGATTHTDFILRAKEKGIKFQVVHNASILNAVGCCGLQLYSFGETVSIPFWTDQWQPDSFFDKIVNNVKNRLHTLCLLDIKVKEPTLESLTMKKKVYMPPKFMMVSEAALQLLQIIDKRKEQGEDPGISEKNVCVGLARVGSESQKIVTCSLKNMSTVDLGGPLHSLIVVGPIIHPVEMEYLVQFEMKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG85</accession>
    <name>A0A6P7FG85_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114327746 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132250.1">
        <property type="nucleotide sequence ID" value="XM_028276449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG85"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276449.2">
        <property type="protein sequence ID" value="XP_028132250.1"/>
        <property type="gene ID" value="LOC114327746"/>
    </dbReference>
    <dbReference type="GeneID" id="114327746"/>
    <dbReference type="KEGG" id="dvv:114327746"/>
    <dbReference type="InParanoid" id="A0A6P7FG85"/>
    <dbReference type="OrthoDB" id="6742238at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027967788" evidence="1">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132250.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16384" checksum="2CC697F09A25A795" modified="2020-12-02" version="1">MAAKLAFFFTFFLVAVYITEAVNVRNKTEAAVKEATETVHLHTADIKNQTENAAKEVHVHTSDIKNETEKVAKEVAQAAEIPKTQTTAAQDIDSTLDNLKAGFEEFVDKVKNNDIVKKATQGIKDLGDTIQQKGKEAYDKITSETKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH87</accession>
    <name>A0A6P7FH87_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114328034</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114328034</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132575.1">
        <property type="nucleotide sequence ID" value="XM_028276774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH87"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276774.2">
        <property type="protein sequence ID" value="XP_028132575.1"/>
        <property type="gene ID" value="LOC114328034"/>
    </dbReference>
    <dbReference type="GeneID" id="114328034"/>
    <dbReference type="KEGG" id="dvv:114328034"/>
    <dbReference type="InParanoid" id="A0A6P7FH87"/>
    <dbReference type="OrthoDB" id="6780401at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028132575.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="55966" checksum="84FBF43DA8AFBF75" modified="2020-12-02" version="1">MAFILPDNILETLLCSFCHKYLSVKPVKVYPNRLIQCGRCVDNEEPSIQKSEGVESLYGMIAQNILFKCVNRFDGCRRLLAYSQVRDHEQVCWAKIHECPICNENMASLMMLPHFRSNHKDVILDYPAFVFELNDDDIEMPSVYLYQEDDNLFFLYISYRKSENTIRLDLEYTGNSKLAKNIYHEFTVSSDNKEFDVVLNSKPCTDDFFYVDISNMSNLIKIEFKIIDRNLKVLTAPEISIAVRKPLKWFIDNPQGGQIEYRSEFNLKCAICQAYCIFSLSTCPVKYYYIDEESDYVCYYCNQFFKLFLETDESSAKKAIPTYIFKTMKFFKWNCSTCCSVIEFSDMQSHEINCKRGRQFSCPIANCCDSAKGIANQMIQHLKNRHNFMAFGSHFKLPRNFLKCYVFFREDIVFLRATDTLDFTSSLDHRSIHAELVIKTDNVEKRPYALFFNTNNEILRDHSKFASDSEVFVKVFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHX8</accession>
    <name>A0A6P7FHX8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC114330545</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028135708.1">
        <property type="nucleotide sequence ID" value="XM_028279907.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135709.1">
        <property type="nucleotide sequence ID" value="XM_028279908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHX8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279907.2">
        <property type="protein sequence ID" value="XP_028135708.1"/>
        <property type="gene ID" value="LOC126878426"/>
    </dbReference>
    <dbReference type="KEGG" id="dvv:126878426"/>
    <dbReference type="OrthoDB" id="6723085at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650937" description="acid phosphatase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028135708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028135709.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="44514" checksum="A1647B0BD5008EFE" modified="2020-12-02" version="1">MGVLTSGLFVSFLGILGVSAELIAVVQVVRHGQRIPVKFFPTSKYLDGEYWGNLGAGQLTNEGKRQLFALGQYTRRRYPNFLPLKYNASSFHAYTTDVDRTHMSAQSNIYSLFPATDEQVWRRNLNWQPIPIHPISRDEFWGDSACPNFYILRTEALNDKLSQSIDEEYAGVYKYISKYSGLDIKSYFQIHTVFDNFKIQEDVGLPLPDWSKAVYPEPITSIAGWLFEVFSRTTQMKRLIKGRFLNKVVEYFEKMADDPKSSEKYQFYSGHDSNIASLLNSFGSFNPPYPPDFASTVYIELHFESWRHVVKVFSKDGDNVKQISVNGCSLSCPLSKFKEVLSDILIDKETYDEECSNIKDTSGLKKLLLADSNTHKITTEEVRETSFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPM7</accession>
    <name>A0A6P7FPM7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114332519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332519</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138161.1">
        <property type="nucleotide sequence ID" value="XM_028282360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPM7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282360.2">
        <property type="protein sequence ID" value="XP_028138161.1"/>
        <property type="gene ID" value="LOC114332519"/>
    </dbReference>
    <dbReference type="GeneID" id="114332519"/>
    <dbReference type="KEGG" id="dvv:114332519"/>
    <dbReference type="InParanoid" id="A0A6P7FPM7"/>
    <dbReference type="OrthoDB" id="188352at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667:SF7">
        <property type="entry name" value="RIKEN CDNA 1810020O05 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667">
        <property type="entry name" value="SI:DKEY-57N24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138161.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="87098" checksum="E617602611E7AF31" modified="2020-12-02" version="1">MITFTVSFLLSFPIVKKKKEKKTKEKPKDKPKEKQKEKSKNNLLKNGAKKSLEPEIPNTEFNSTNILSAAHIQYELIPNRCKYDIDVVCWGPVAKIITNDGQIFLFTVINNDRIWVPIRMEHYLDKMSIKEIKKFQPKIINFNIVNNINNAPGLLKNETLFIPTSKVINEETKSFKSRSVFKLVKDDLDSESDQDKKSLEAFMKNIILSCANHPKDDTPVSWLNNVVDYSVFYEAIQNVDSGKLVVNEAIYACSKDDEEPKKANGKDSKNAKKTNNTETKNDKKVKKGKETKSKDTLTVKVPAEIFFTESYMATYRVLAKNSFANNVLVFVSAKNLLSRAQKLALNPLVVKIFKIIDLPAEKVKEHDFDSVYVRYYIPEVLQCRTVAKVIDDTVMFNEAHMHFVDNIPKIRLVQQLEISKLFVEIYGNKIIKQEEQQCSLFGTHSKDFQISKIGPIFEHIEEPETKVTSVLLAVSTFDISSLAHNVWDFREAAQCHEPYLNISRNFVYDEIRYIDIKTVNEINLKPEKRDESLSEKTLLEFGTTVCVEVYLMAPQAPALVYHHAQNTFKRIFFILNEESFAKKIYNALVTYNSAIQTANNKDILTGFLLDNGNNYFFYIEGLAIGFILSLWHMVEETCPMEGQEYGADNKPICKGKVFFNTDNAFEKRLYSHFLPVGIYIINLKFPLQDILAIPGIYCRNNIPKPCLQALIKLCSLFHARYYKEVFQQNLLPLPQELVSLNLEWGVPLRWKENVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPU4</accession>
    <name>A0A6P7FPU4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BUB3-interacting and GLEBS motif-containing protein ZNF207</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114332616</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138236.1">
        <property type="nucleotide sequence ID" value="XM_028282435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPU4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282435.2">
        <property type="protein sequence ID" value="XP_028138236.1"/>
        <property type="gene ID" value="LOC114332616"/>
    </dbReference>
    <dbReference type="GeneID" id="114332616"/>
    <dbReference type="KEGG" id="dvv:114332616"/>
    <dbReference type="CTD" id="35004"/>
    <dbReference type="InParanoid" id="A0A6P7FPU4"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028138236.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="42942" checksum="4406F510557AD11D" modified="2020-12-02" version="1">MGRKKKKLSKPWCWYCNREFEDEKILIQHQKAKHFKCHICHKKLYTGPGLSIHCMQVHKETIDKVPNSLPNRSNVDIEIYGMEGIPAADLREHERQKQGSRPANDSGSDDDEPAVKRPKPEGLLGSAPGVMQGMPNMVPGMMPPPGMPPGMPMGPMMQMGPMGPHFMPHPGMQMMPPHMQQMMQGQGGPPKPLFPSAIPTSSPGAQGTPVVGADFKPISSAATISAPPTTNTPAGSSNSTDVKASTIATSSATSKIIHPSEDTSLEELRSRNPKYARSISKSDDGASSSSTAASELAIAVSAAQQAAAQQKHVDAMNHHAAMMQRFPVRVTGPPIGMTMGGPIMAPMRPQMIPGPPTLIGGPLMRPPPLSMPPGMIGMPPGMMYGAHMFPTGPVLMQPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPX8</accession>
    <name>A0A6P7FPX8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PDZ and LIM domain protein Zasp-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114332799</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138374.1">
        <property type="nucleotide sequence ID" value="XM_028282573.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501629.1">
        <property type="nucleotide sequence ID" value="XM_050645672.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FPX8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645672.1">
        <property type="protein sequence ID" value="XP_050501629.1"/>
        <property type="gene ID" value="LOC114332799"/>
    </dbReference>
    <dbReference type="GeneID" id="114332799"/>
    <dbReference type="KEGG" id="dvv:114332799"/>
    <dbReference type="InParanoid" id="A0A6P7FPX8"/>
    <dbReference type="OrthoDB" id="5911912at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09455">
        <property type="entry name" value="LIM1_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09461">
        <property type="entry name" value="LIM3_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09360">
        <property type="entry name" value="LIM_ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000060">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000069">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000073">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="283"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1541"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="955"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1127"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="955"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028138374.1"/>
        </source>
    </evidence>
    <sequence length="1656" mass="181520" checksum="AD906EB6C7FF51D0" modified="2020-12-02" version="1">MASLITVHLNKGGSPNLGFRLQGGKDFGTPLLIQKVNVGSPAERAGLVAGDAVIKINNTDVYNLRHKDAQDVVVRAGPSFEISVQRGGSTWIPSVIPTGPLSAPSPYVNSSGPVTRTSLAANKSENIGSIGTGHNLSAKPFSPQLNGSVNGGPKLVNKQYNTPLKLYSEESIAETLSAQTEVLSTGALGVNFKKNERNYDSSNSEVLRALKEAENEPSYPDHVIRTDYYSTQSHAIGGRKSTTPNPIASEQYRSLNEQSRPVAVGSTQTQPEFPKPTPAEGATVCTDCERVIVGVFVRIKDKNLHVECFKCSTCGSSLKNVGYYNINNKLYCDVHAKSAALKNQTNPNLVPITIPPGGRAPAHAISSALSSHSYPTSSPLSPKLNTAGTQYQAEETNENVDVTSSSSLLAKSNVIESNTSNNNLFSNSTPVSYSKYLNNKTNYSGPKPFSSVNAPLSPHNTLPRAAPLSPVAPAPSFNSHSYTPSAYSPSSDVHVAENIVWPPPQEEPEVPTACPLFYPPPSQIEQKILSKRKEKELETEEDCSEIEEINEMAQYSQNVFSEYSSRRKSTEECRETLTGTLDTQLLIENIVKKSVGPPSLNEDILIKPQLEQDLRTDKLKCPLSLNESLCCQKKDVKSCELKRPTEYSPNTVERFTPTIDNAVPLKWESPLTQAIRTTSPDKDTFASIPTKHSHSALASALSVAPLDPFTPTGIHDEPVPLPEETVPYFPPERPVLPVDIEASKSDGTAPVPPIRKKFKNPNDKLLEDLPKPQERLSLLAALTTAPDRPYSPFIELSTGPDKNQNVIEKPPRSDLNRPVKPDVLPESFTVHKKEPKPPTYYPPSLLYQRTEEAKCEEHTEESNVTKTTTVQKQTIQKPEVVQTVVEENPTTSQIIPPIFHGFSCSFQNKGDISQFSVDVRTTPPIISPPPIAPVVKTIESKQGYVQREIVTEERIEKQKTSKKSEQKEERTIQQACQPSNRPVIKQAEESITVKPIPPVALRKPTQLPQYQVDISAEAESELIMYEKKRQAEIRLEQEKQNKIQQNIVAANKAPVRVLPAQKPIIKIESEDTNNTFRPVVEENPPIHSFSPRSGTITPSKQGKAPAILPYYQVNLVPQHMAATHSNIFDPKSPAVSRSPSPFVGATKERSPSPLPGTASNIRAASPAPGPPENPLTSSKPLPNPESIRIDQARDSLTHYLPEYKTKMDLIELGQKSELFGHSYGQNSQMYTSLVQTQNFPTVPVDQSHIQCFEMQKADLLQAQRTEKNISQLGDTVVSTSVDEQMRQAHLEQLKQSQSHSVERSADGLTQIQRKKVVTEEFERSQKEVNIQIEKNVSSVRKHPFTEVNVPSLGEPSIKGHVTDPQRISVKKSEGTQKEVCQKLAGPLQAPPPATLQSSATASLGSTASASTPIKHVYAPSSIAPVKHVTPPSSSNKPNVSCVSQPDTGAGSGKQSTGVRIAPRRGRGILNPAAIGGARIPLCGSCNMQVRGPFITALGKIWCPNHFICSTPSCRRPLQDIGFVEERGQLYCEYCFEQYLAPPCSKCGGKIKADCLKAIGKNFHPECFNCTYCGKLFGNSPFFLEDGSPYCDADWNELFTTKCYACAFPIEAGDRWVEALNNNYHSQCFNCTMCKKNLEGQSFFAKGGRPFCKNHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQS5</accession>
    <name>A0A6P7FQS5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114332999 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332999</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138606.1">
        <property type="nucleotide sequence ID" value="XM_028282805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQS5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282805.2">
        <property type="protein sequence ID" value="XP_028138606.1"/>
        <property type="gene ID" value="LOC114332999"/>
    </dbReference>
    <dbReference type="GeneID" id="114332999"/>
    <dbReference type="KEGG" id="dvv:114332999"/>
    <dbReference type="InParanoid" id="A0A6P7FQS5"/>
    <dbReference type="OrthoDB" id="6702328at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027669743" evidence="1">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138606.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16228" checksum="BFCC7F35A01A2879" modified="2020-12-02" version="1">MSKSIIYTSIFYLIVIELAITEAAPQSDIKELQNLLQALSENCARKAKISQHLATNIENGIFEDDAKSKAYVACNWLDSTVIDEQGNLNEDILDHLCPPSKKPQLTNLIIRCHKAQPKNQSVEDIIYGMSKCIYPEDTTLFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FS09</accession>
    <name>A0A6P7FS09_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114332061 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114332061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137572.1">
        <property type="nucleotide sequence ID" value="XM_028281771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FS09"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281771.2">
        <property type="protein sequence ID" value="XP_028137572.1"/>
        <property type="gene ID" value="LOC114332061"/>
    </dbReference>
    <dbReference type="GeneID" id="114332061"/>
    <dbReference type="KEGG" id="dvv:114332061"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028137572.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29977" checksum="AEA4AB1B89D4471D" modified="2020-12-02" version="1">MSNLIQIKFKLIDRNLKVLTAPETSNVVKKPLRKSIFGTLGSQIEHRSEFNLKCAICQTYCIFSFSSCPVTYYYIYEDNKIVCYYCTKCFKLFFATGKLSKRTIPTNILETIKFFKWYCSGCCNEIEFSDMQSHEIICKGGRQHTCPIKYCFEKGTANKMTEHLKDWHGKIAFGSHFKLPTNFGSCYIFVREHIVRLRVTSEFSLTSSLDHGSVHVELVTKNDGDDHISPYALFCNKKNEIITDYSKLASSSEVFVKVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSY1</accession>
    <name>A0A6P7FSY1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114333670</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139411.1">
        <property type="nucleotide sequence ID" value="XM_028283610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650055.1">
        <property type="protein sequence ID" value="XP_050506012.1"/>
        <property type="gene ID" value="LOC126884191"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FSY1"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435:SF9">
        <property type="entry name" value="PROTEIN NATD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028139411.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12393" checksum="12D844E2D989FC84" modified="2020-12-02" version="1">MKGIRNLSAVRSKLISNPVEDNTSEKILKTSLNGDFATLEYEKIGANSYDLIHTNIPEEYHGQGLGTVFAHKIFEHLASKNIKFKLTCEFLENVFNKSGKKYQDYLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTV8</accession>
    <name>A0A6P7FTV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein wntless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC114332620</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Postsynaptic cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynaptic cell membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138242.1">
        <property type="nucleotide sequence ID" value="XM_028282441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTV8"/>
    <dbReference type="FunCoup" id="A0A6P7FTV8">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282441.2">
        <property type="protein sequence ID" value="XP_028138242.1"/>
        <property type="gene ID" value="LOC114332620"/>
    </dbReference>
    <dbReference type="GeneID" id="114332620"/>
    <dbReference type="KEGG" id="dvv:114332620"/>
    <dbReference type="InParanoid" id="A0A6P7FTV8"/>
    <dbReference type="OrthoDB" id="5804250at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="23">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="22">
        <location>
            <begin position="233"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_028138242.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="59854" checksum="993A9E6C2E53C356" modified="2020-12-02" version="1">MPGTILENLSGKKLIILISVVLTCQIACFLVGLMAPMLANNTQITLSTVCVDQNPSESERNFDRWFVRTCSKTNELTDDKETVDLDANSLVYVIEMPLFDLDYSRWQQKLLGILQVEMVDQKKQKLIKPFIELTVDSRIAYSDKTPNGGKTPWKFYFHAEEKRYMKCTLNNQYDPQNRGYPYNYCTMVPLFELGALYHDYYLLNLRLPYNDTTKKNIGLGKVEDLYVHTTYVNGGFTKIWLSLKSVLFPILLAVMIWFWHRVIKLNRTPVLLEYVLISLGGTLAFLNIPIEYLSLIFEIPYMLLLNDIRQDAFYVMLFLFWLIFAGEYMLVQNQGDRNSIRCYWKHLTTIIVGCMSLFIFDLYEKGLQLVNPFYSIWVTPLSTNLAIAFVILVAIAASTYFVFLCYMIWRVFKNISVKIFVLPNMSQARRRHYEGIIYRFNFLMLVTLICASVTIVFFVLSKIDEGPHKWDTTIYLKPSSVVYTGVYGMWNIYICTMLILYAPTHEQWLTDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVL3</accession>
    <name>A0A6P7FVL3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAC3 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334533</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140396.1">
        <property type="nucleotide sequence ID" value="XM_028284595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVL3"/>
    <dbReference type="FunCoup" id="A0A6P7FVL3">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284595.2">
        <property type="protein sequence ID" value="XP_028140396.1"/>
        <property type="gene ID" value="LOC114334533"/>
    </dbReference>
    <dbReference type="GeneID" id="114334533"/>
    <dbReference type="KEGG" id="dvv:114334533"/>
    <dbReference type="InParanoid" id="A0A6P7FVL3"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF38">
        <property type="entry name" value="SAC3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140396.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="42147" checksum="D264B2220ABADD7C" modified="2020-12-02" version="1">MDNSNNEVYTIGTCKEMCPFREARLRERQGLLHILEVVPGTENNKNPKADVKRVVKEFTRSAAGKSFLISGNLRPPDVLLKTINYLLDEVISNKEVPWMVKYDFILDRLRAVRQDMVIQNVSRPHQIVILQPIIRFLTYSSYRCCEEAINTYDPHINNTHLQECLKRLLCTYDYFDNLEKSSKQEISNNFLVESRPYFESLYLIFNMGDVSALNRYLNLPPQWRTSLVKTSMRICLNYVNRNISKVIKLSKQLPLSLQMIAFLHLPEIRRITLKIMSSAYHSKNLRFPLDVLSDMLLYNSVNELIKDCNYYGLKTEQGGVHFMKCDFLEDKVKMKPRRSKEIDKTLEDTDISMFLLYGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX19</accession>
    <name>A0A6P7FX19_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein C3H8.02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114331936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137428.1">
        <property type="nucleotide sequence ID" value="XM_028281627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX19"/>
    <dbReference type="FunCoup" id="A0A6P7FX19">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644448.1">
        <property type="protein sequence ID" value="XP_050500405.1"/>
        <property type="gene ID" value="LOC126880531"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FX19"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="77"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028137428.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="26259" checksum="39E01C6B20DF73D2" modified="2020-12-02" version="1">MSEVQLKPVNEADFQDLKSRMKLIAEADPTQYHNDFSLRRYLRAFKTVDDAFKAILKTNKWRKEYGVENLTADSPEVKSNLDANKARVLRHRDMFGRPVIYIPAKNHNASNRDIDELTKFIVYCLEDACKKCFEEVVDNLCIVFDLQDFGVSCMDYQLVKNLIWLLSRHYPERLGVCLIINSSSLFSSCWAVIKGWLDENTTSKVTFVGSEEELCKYLIPDILPTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXH4</accession>
    <name>A0A6P7FXH4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leukocyte receptor cluster member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335249</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141259.1">
        <property type="nucleotide sequence ID" value="XM_028285458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXH4"/>
    <dbReference type="FunCoup" id="A0A6P7FXH4">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651026.1">
        <property type="protein sequence ID" value="XP_050506983.1"/>
        <property type="gene ID" value="LOC126884792"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FXH4"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141259.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="34933" checksum="53E4991E85CFB966" modified="2020-12-02" version="1">MNILPKKRWHVRTKENIARVRRDEAKALEEEKARQDRVKLAEREARRELLLNRSRSTTGFKPDIDIKEDTNDNKHINFFEELEEGTAEIKHVNKEHEKEKKEEKEKYEKQIGYLTYLGQDTNEALGKKSWYNIAPDRSDVKHEVNLKTKIREDPLHMIKKYNLESDKKATHDNIPSTSRTVKESDSICRQISVSKQTKKHKHKKHKKHKKRKYSTSSESSEDDTEHKIEKQKELEILRIKRLKREAEEREKTNAVLSKLKKKDVEPADNSTKVNNFKAKYNSQFNPYLAKQNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FY77</accession>
    <name>A0A6P7FY77_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335493</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141534.1">
        <property type="nucleotide sequence ID" value="XM_028285733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FY77"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646156.1">
        <property type="protein sequence ID" value="XP_050502113.1"/>
        <property type="gene ID" value="LOC126881721"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FY77"/>
    <dbReference type="OrthoDB" id="7694007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028418524" evidence="2">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141534.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51229" checksum="AF05E63AB4172BFC" modified="2020-12-02" version="1">MRVLVLILCVAFLHLVAGACYDSKEECHSTNYETYVECVRRRQKRSTDCESRCDSGNCIDTCQECDCSSCSYNSCTSSCGSCCSSCCSNYVPCHTNHCCHKTCHAQCSTSSCRSNCRKNCFDIVKERSQTVVVEPGEETISKTNANINNVNKPNITTIIHLNNIINTTNLVDIPIILNNTNTQNITLFNEETGLSTTLQCCTVISPRECVSSPQPRCFHYRTKECGSFCTASIVHKEEQKLCSVNYPGAAPSCSKQIYYIPQPQPKCTYQSVWPYVSCGIQKKETCQGCYSHYVNGGTPNYLTCPPQCYDDGFGAVGPMYRQGPVYRPGYSHAPCYQCLGYPNPNEYSGYPVPYGGSQPYLGEYQQAPFSGYQQPYGGYPLPYGGYVAPPYFPVSTEVNGTIPIQVNENLMDEGRVPRELEIEVNYEQPSDAQAEVKIKEDDESNLVVEEEKKEIVEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYG6</accession>
    <name>A0A6P7FYG6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">LIM and SH3 domain protein F42H10.3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114332079</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137590.1">
        <property type="nucleotide sequence ID" value="XM_028281789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYG6"/>
    <dbReference type="FunCoup" id="A0A6P7FYG6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281789.2">
        <property type="protein sequence ID" value="XP_028137590.1"/>
        <property type="gene ID" value="LOC114332079"/>
    </dbReference>
    <dbReference type="GeneID" id="114332079"/>
    <dbReference type="KEGG" id="dvv:114332079"/>
    <dbReference type="InParanoid" id="A0A6P7FYG6"/>
    <dbReference type="OrthoDB" id="191061at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11789">
        <property type="entry name" value="SH3_Nebulin_family_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000007">
        <property type="entry name" value="nebulin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028137590.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34101" checksum="E0A51DC96A9E5A49" modified="2020-12-02" version="1">MSKKCARCEKTVYPTEELKCLDKVWHKLCFKCKDCGMALNMRNYKGFNKEPYCEAHIPKAKATTMAETPELKRIAENTKLQSNVKYHADFEKSKGKFTQVADDPEMLRIKQNTKIISNVAYHGDLLRKAEMEQKRQINENSNGFKDPDLKNANQPQPQPTYNASSSHSQPPAPMQTPVTKSMGKIDDYDPQATAGQYQSPYSSRNSQTLIYSSDVGSVNNPPQRHIGSVHDMDPVNHNYGSLGRVYRAMYDYEAQDIDEVSFQDGDLIVNVQSIDGGWMTGEVQRTGQVGMLPANYVQMVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G075</accession>
    <name>A0A6P7G075_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cation transport regulator-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114336158</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028142289.1">
        <property type="nucleotide sequence ID" value="XM_028286488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G075"/>
    <dbReference type="FunCoup" id="A0A6P7G075">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286488.2">
        <property type="protein sequence ID" value="XP_028142289.1"/>
        <property type="gene ID" value="LOC114336157"/>
    </dbReference>
    <dbReference type="KEGG" id="dvv:114336157"/>
    <dbReference type="InParanoid" id="A0A6P7G075"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028142289.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21207" checksum="E2A790CC353B8313" modified="2020-12-02" version="1">MWVFGYGSLIWKIDFPYERKVLGYIKGYDRRFYQLSTDHRGTPENPGRVVTLVPSEVNSKVYGVAYKISETDVKKVVDHLDHREKGGYEKKTLEFFPICEDQQTFNITIYLGDHENENYGGPADLNDIAAQVVASEGPSGPNVDYVCNLANAMRNFFPSVQDEHLYELEKKVLNLLRKNNGVCTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G702</accession>
    <name>A0A6P7G702_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114338121 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114338121</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144839.1">
        <property type="nucleotide sequence ID" value="XM_028289038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G702"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289038.2">
        <property type="protein sequence ID" value="XP_028144839.1"/>
        <property type="gene ID" value="LOC114338121"/>
    </dbReference>
    <dbReference type="GeneID" id="114338121"/>
    <dbReference type="KEGG" id="dvv:114338121"/>
    <dbReference type="InParanoid" id="A0A6P7G702"/>
    <dbReference type="OrthoDB" id="10582838at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028144839.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="16759" checksum="521E32830685D5A3" modified="2020-12-02" version="1">MVEEVIEIISSDTSIHLSPKPARANIREESMEVTNNDHPHCGEGRLNEVTLEVSAIPTATATTSKTPTAPTCIDVIVLYRNDLYCSSATSCEQELLDTEYCALSVENVANDEETSEYFARHHENMTASPISKAWIWIKQHLCFGGVELDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9D5</accession>
    <name>A0A6P7G9D5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuropeptide-like protein 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114335409</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141443.1">
        <property type="nucleotide sequence ID" value="XM_028285642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9D5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285642.1">
        <property type="protein sequence ID" value="XP_028141443.1"/>
        <property type="gene ID" value="LOC114335409"/>
    </dbReference>
    <dbReference type="GeneID" id="114335409"/>
    <dbReference type="KEGG" id="dvv:114335409"/>
    <dbReference type="InParanoid" id="A0A6P7G9D5"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028011719" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028141443.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="8561" checksum="AF9BD0A448DB34EE" modified="2020-12-02" version="1">MKLFLIAFVVCLAISSSSAHPSWVHGGWGGLGGWRGNGGWRGNGGWGGLGGWSGNIGWSNPIALGGHIPITHYGGGHAGLGVIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9S0</accession>
    <name>A0A6P7G9S0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114335516</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141568.1">
        <property type="nucleotide sequence ID" value="XM_028285767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9S0"/>
    <dbReference type="FunCoup" id="A0A6P7G9S0">
        <property type="interactions" value="1647"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285767.2">
        <property type="protein sequence ID" value="XP_028141568.1"/>
        <property type="gene ID" value="LOC114335516"/>
    </dbReference>
    <dbReference type="GeneID" id="114335516"/>
    <dbReference type="KEGG" id="dvv:114335516"/>
    <dbReference type="CTD" id="33269"/>
    <dbReference type="InParanoid" id="A0A6P7G9S0"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 12" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="232"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028141568.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39812" checksum="B5AC2EA196EB67DA" modified="2020-12-02" version="1">MPNSDIDDNEKVTGPVDNAWELKIPEFKPEDNPHGLLEESSFATLFPQYREQYLRQVWPLVKKTLGEYNIKAELDVVEGSMTVKTTRQTWDPYIIIKARDVIKLMSRSVPFEQAKRVLEDDVGCDIIKIGKITRNKEKFVKRRQRLIGPNGCTLKSIEILTNCYVLVQGQTVSALGPYKGLQQVRKIVEDTMKNIHPIYNIKALMIKRELAKDPKLKNENWERFLPKFVNKNISKRKQPKNKKDKKPYTPFPPAQQESKIDKELATGEYFLNKTQKKAKKQKEKDDKHSEAAKKREEKRNQAFIPPEEPTTSKTQSKTNTKVDIASLKEKITKARKGSKIFNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEI4</accession>
    <name>A0A6P7GEI4_DIAVI</name>
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        <submittedName>
            <fullName evidence="9">Zinc finger HIT domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114336360</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142515.1">
        <property type="nucleotide sequence ID" value="XM_028286714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEI4"/>
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        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286714.2">
        <property type="protein sequence ID" value="XP_028142515.1"/>
        <property type="gene ID" value="LOC114336360"/>
    </dbReference>
    <dbReference type="GeneID" id="114336360"/>
    <dbReference type="KEGG" id="dvv:114336360"/>
    <dbReference type="InParanoid" id="A0A6P7GEI4"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028142515.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="19394" checksum="C4954A28943661AC" modified="2020-12-02" version="1">MTISKSTLRGSNRIRENDKRRIVDETSRKRRHRKVMELLESDNYHEDPHADLVMSKKVPKFEDNLEHRSTRTKKRERTTEYYQFKYRKNFQQLVDEDRVDADISKRVSYMDIQCEDSPIPPRHFCAVCGFLGQYSCLSCGTRYCCIRCMDTHIDTRCLKWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF51</accession>
    <name>A0A6P7GF51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114337403</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143623.1">
        <property type="nucleotide sequence ID" value="XM_028287822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF51"/>
    <dbReference type="FunCoup" id="A0A6P7GF51">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663563.1">
        <property type="protein sequence ID" value="XP_050519520.1"/>
        <property type="gene ID" value="LOC126893413"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GF51"/>
    <dbReference type="OrthoDB" id="10067025at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028143623.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34978" checksum="7016F005E9801AFE" modified="2020-12-02" version="1">MAAPPHHFMQNLNNPQPTAMRSSFGPSPMQTQMAPGGMQTAMPTQMPVQLSNPMGSPMVSQMSNPMNGTLTPMNPSMNGGSPMLSQMNQHYNMSSPMNGGQMGPHQPPTQIPMQSRPMEFAPALNHHEMPQQTPTVAPTPPPVPVQQQQQQQQAKEFNTASLCRLGQETVQDIISRTQEVFQTLKQIQPPNGTPQSLNTSNEKKAKVQELLRTIRVLFKRLRLIYEKCNEICQLQGMEYTHIESLIPFKDELDPKHDEKKNSEAYRTACDESKEVMEQVILKNKQLKEVIDHLRRIIWEINTMLTMRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQY9</accession>
    <name>A0A6P7GQY9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114339718</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028146195.1">
        <property type="nucleotide sequence ID" value="XM_028290394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028290394.2">
        <property type="protein sequence ID" value="XP_028146195.1"/>
        <property type="gene ID" value="LOC114339718"/>
    </dbReference>
    <dbReference type="GeneID" id="114339718"/>
    <dbReference type="KEGG" id="dvv:114339718"/>
    <dbReference type="InParanoid" id="A0A6P7GQY9"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027932909" description="acid phosphatase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028146195.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45139" checksum="0306AB5C8682F021" modified="2020-12-02" version="1">MMTNSSNFKFAYLVLVCCFILVVAAKDAKTNNYSSELVAVAVIFRHGDRSPLASFPTDEYFKNLKDYFPMGLGQLTKKGIQRQYKLGQWLRQKYKGFLNESYSNKDIYVQSSNIDRCLMSASATLAGLYPPKGDQVWNDELLWQPIPVHVGSEAYMRSQDCHKLKKLYKKTLKVYNKVFRERYLQLFEYISAYSGFEDVTIFNVASVRSSMNIYKHYNTSFIPEWIRKIDQKTLDFIAATKYIIPTATQILTRLSVGVFYNYLFENLDKFIDSSVTDKPQKFMLMATHDTTISPILDGMGLYNMRPIGFSDAFIIELRKTNEGSYFINFLFKSEDKLEQRVLKDCEFDCNYSAVKKLLKNVTIDLDTRRMECAERGKMKAIKDGKDDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVD1</accession>
    <name>A0A6P7GVD1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114341224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114341224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147820.1">
        <property type="nucleotide sequence ID" value="XM_028292019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVD1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292019.1">
        <property type="protein sequence ID" value="XP_028147820.1"/>
        <property type="gene ID" value="LOC114341224"/>
    </dbReference>
    <dbReference type="GeneID" id="114341224"/>
    <dbReference type="KEGG" id="dvv:114341224"/>
    <dbReference type="InParanoid" id="A0A6P7GVD1"/>
    <dbReference type="OrthoDB" id="6761337at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028147820.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24467" checksum="7DB867FF639E3B80" modified="2020-12-02" version="1">MRLLHLVTPDIEKQTTNMRESISAKHRLIITLRFLATGNSYRSLMYEFRVSKSTISKFVPEVCALIYKRLKDYLKVPNTAADWLNIAEEYQNIWNFPHCLGTMDGAPSSAGSTFFNYKGTHSRARRVVENAFGILANRFRMDLSKLNKVSSIADKKPIIILRDLTRDAHFTIIAAKVVNAKYGEAVLLELEEKVVFLPNRVTKDYVSFLPEFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVZ0</accession>
    <name>A0A6P7GVZ0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/threonine-protein kinase TBK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114347138</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153679.1">
        <property type="nucleotide sequence ID" value="XM_028297878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVZ0"/>
    <dbReference type="FunCoup" id="A0A6P7GVZ0">
        <property type="interactions" value="1355"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646772.1">
        <property type="protein sequence ID" value="XP_050502729.1"/>
        <property type="gene ID" value="LOC126882003"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646773.1">
        <property type="protein sequence ID" value="XP_050502730.1"/>
        <property type="gene ID" value="LOC126882003"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GVZ0"/>
    <dbReference type="OrthoDB" id="10013850at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12219">
        <property type="entry name" value="Ubl_TBK1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000100">
        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000106">
        <property type="entry name" value="serine/threonine-protein kinase TBK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041309">
        <property type="entry name" value="TBK1_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041087">
        <property type="entry name" value="TBK1_ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF15">
        <property type="entry name" value="FI05319P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18394">
        <property type="entry name" value="TBK1_CCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18396">
        <property type="entry name" value="TBK1_ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028153679.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="85179" checksum="FF186C27B3F72E2F" modified="2020-12-02" version="1">MSSYLRGSTNYVWSTTSILGKGATATVHQGVNKVNGEPVAVKTFNQLSTLRPQEIQLREFEVLQRVNHENIVKLLAIEEEQENRGKVIVMELCTGGSLFNILDDPENTYGLEESEFLLVLEHLYKGMKHLRDNNLIHRDLKPGNIMKYIRDDGTTVYKLTDFGAARELQEGQYFQSLYGTEEYLHPDMYERAVLRKPANKTFGATIDLWSIGVTLYHVATGNLPFRPYGGRRNKETMHQITTKKESGVISGIQYREGGPIEWKRELPMNCQLSYGLKKIVTPLLAGLLEADHRKIWSFDKFFNEVDVILSRKLFHIFHVNKAQLIKIYILPIENYTHLQSYIAEQIEIKENSQILIYQNNLLKNLIEDYTLITGYPKTTKEDPYFLFDRENNNITVVPDPELPKFNEFSNVMSVENDAAQAKSACSIGHQYKRQIDKYSLFSKLIRDTVQYFTKYITTVLQELHQNTQHLLDKTLTLQKTADILQISQQISRYNNKTNFVEKLESLSKDFLTISVQGVTNLHKTHCTDSNLKLQWENTNRNLKCPYKTLSPARAKSQVEHLRDSWQHLVRDRATRTLSYNDEQFHILERIKITQTLNRLKNLFEHEVFPQYEQLAENFGDWYKIAQNIHLKSEILISDVKKYESKLTEFEEDIAIENSDYMDFVKSNNKQNTVPKVRNLQSQKLKQCFTEYHKECKNIKDVLNENVKLTTYLNDSTMEIMKKINANDNTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GW74</accession>
    <name>A0A6P7GW74_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114341477</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028148080.1">
        <property type="nucleotide sequence ID" value="XM_028292279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GW74"/>
    <dbReference type="FunCoup" id="A0A6P7GW74">
        <property type="interactions" value="2179"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292279.2">
        <property type="protein sequence ID" value="XP_028148080.1"/>
        <property type="gene ID" value="LOC114341477"/>
    </dbReference>
    <dbReference type="GeneID" id="114341477"/>
    <dbReference type="KEGG" id="dvv:114341477"/>
    <dbReference type="InParanoid" id="A0A6P7GW74"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028148080.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47304" checksum="026B9E24BBC618D5" modified="2020-12-02" version="1">MPKKLKIAFIHPDLGIGGAERLVLDLAGALTLSGHEVRFLTNHFDPTHAFDELKNGDYPVEVYGDWLPKSVFGRFQALCAYVRMVYMSIVYLLFFKNKDKPDLYITDLIPVANVFLKIAGEKVIYYCHHPDLLASTPGGELKKFYRKPIDWVEMKTTGKADVILVNSEYTASIFRKTFSSIHKDIQILYPTIARSYQNTVENLREAKPIQELVPQIKKAADTIVFLSLNRFHPAKKLEFAILALAKLKNLVSKEDWEKIYLIIAGGYDPQFALNAITYLDLVNLTKEKQLEDKVIFLKSPNDNLKAELLKSCTCLLYTPVKEHFGIVPLEAMLVAKPVIAIDSGGPRETVEHGVTGYLSEPTGDSMAEFMSRIVSENVEEMGTKGKNRLEEKFSYTIFKNNLNSVVNNLMEDDINKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZC4</accession>
    <name>A0A6P7GZC4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114342524</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149140.1">
        <property type="nucleotide sequence ID" value="XM_028293339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZC4"/>
    <dbReference type="FunCoup" id="A0A6P7GZC4">
        <property type="interactions" value="1667"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293339.2">
        <property type="protein sequence ID" value="XP_028149140.1"/>
        <property type="gene ID" value="LOC114342524"/>
    </dbReference>
    <dbReference type="GeneID" id="114342524"/>
    <dbReference type="KEGG" id="dvv:114342524"/>
    <dbReference type="CTD" id="9443"/>
    <dbReference type="InParanoid" id="A0A6P7GZC4"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028149140.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25985" checksum="7FDED32E52593133" modified="2020-12-02" version="1">MANSDTIQVSSLPLPPMQYVSQYTDEAIRRGRTPKPPPPIQDTYHMFGNAFNTEESIIRPLESQGIKRLYPLHFDRRRELKKFNQSLLANFLDLLDLLVNCPDSPRRAEKVEDLSLLFIHIHHLLNEFRPHQARETLRVMMELQKRQRIETANRFQKHLDRVMDILQQAIQNLPEPMDLDSKIMIDTDFLMHSENSDNSETSQDPCYILDRVMCNIVDNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H0W4</accession>
    <name>A0A6P7H0W4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger Y-chromosomal protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114349446</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155626.1">
        <property type="nucleotide sequence ID" value="XM_028299825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H0W4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028299825.2">
        <property type="protein sequence ID" value="XP_028155626.1"/>
        <property type="gene ID" value="LOC114349446"/>
    </dbReference>
    <dbReference type="GeneID" id="114349446"/>
    <dbReference type="KEGG" id="dvv:114349446"/>
    <dbReference type="InParanoid" id="A0A6P7H0W4"/>
    <dbReference type="OrthoDB" id="6690766at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028155626.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46471" checksum="195BB3BB0B4EACF9" modified="2020-12-02" version="1">MKTSIETLASEENEEFNSEKNVLRCLDCEFETENIDELDDHILANHELKDEVVHSEDKFVIVQDDDHPARNTRKRTRSTRPKNLPKDIPRAKIIVKNHDPKFKLCDADECEEDGKPGRPPKRGKRHPSEPMNCELCDFNTTKKSVLATHMLNHSDLVPPVFYKCSQCPYQTKRKNDMPKHMLGHCSNAQLYNCFECPYATKRKSDLTKHVLCHRPTDTVPLYKCSHCPYVTKRKGDLPKHEMNHADKSQMFTYKCTECEYFSKRKNDLHKHMLIHSDRQLSGLYKCLKCAYATDKVARFSNHVMSKCVFWESPISLEHIMLEDILATVDKDGVHVLLNESDDENTNEHAEFVRYIEHAAIKSGVVQADDADAPTVVEGETVEAQLVEEEGAIVIKSDDVEDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1Z4</accession>
    <name>A0A6P7H1Z4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114345095</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028151718.1">
        <property type="nucleotide sequence ID" value="XM_028295917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1Z4"/>
    <dbReference type="FunCoup" id="A0A6P7H1Z4">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659582.1">
        <property type="protein sequence ID" value="XP_050515539.1"/>
        <property type="gene ID" value="LOC126890556"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659583.1">
        <property type="protein sequence ID" value="XP_050515540.1"/>
        <property type="gene ID" value="LOC126890556"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659584.1">
        <property type="protein sequence ID" value="XP_050515541.1"/>
        <property type="gene ID" value="LOC126890556"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659585.1">
        <property type="protein sequence ID" value="XP_050515542.1"/>
        <property type="gene ID" value="LOC126890556"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H1Z4"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028151718.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30225" checksum="A65B55B411E040D1" modified="2020-12-02" version="1">MGLLLYTLGSLTLLAILWTVSSVARYVLKFACFGVLCMIFACAPIPLMLLNPRNSKNALIPSALLRWSRKFYGLEYKVEGLENIDKDSGSVVLINHQSAIDLLVLAYLWPLMPNSTVISKKEIFYIQPFGLAAWLWGTIFIDRVKAKDAQSAVNKTGQIIKRRKARVLMFPEGTRNLGKKLLPFKKGAFHLAIASQVPIQPVAVSRYSFMGNARFDSGAVTIRILPTIPTEGCTVEDIPKLIDQTYKALSENVDEISAPTSTMNGTEAKIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAQ8</accession>
    <name>A0ABM5IAQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128712.2">
        <property type="nucleotide sequence ID" value="XM_028272911.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272911.2">
        <property type="protein sequence ID" value="XP_028128712.2"/>
        <property type="gene ID" value="LOC114324956"/>
    </dbReference>
    <dbReference type="GeneID" id="114324956"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003949">
        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01464">
        <property type="entry name" value="EAGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="390"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="603"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="761"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128712.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="862" mass="96176" checksum="F15083147207CD17" modified="2025-10-08" version="1">MMSLSADIMPQYRQEAPKTPPHILLHYCAFKAIWDWIILCLTFYTAIMVPYNVAFKNKTSEDVSLLVVDSIVDVIFFIDIVLNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLLSCLPYDVFNAFDHDEDGIGSLFSALKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVAHWLACVWYSIGRSDADNGVQYSWLWKLANITQNPYSYVWPNDSSTPELINGPSRKTMYVTALYFTMTCMTSVGFGNVAAETDNERIFTICMMIIAALLYATIFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGLDQDKVLNFCPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFTMSHSAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVVAILGKGDVFGDSFWKDNAVGQSAANVRALTYCDLHTIKRDKLLEVLDFYQAFANSFARNLILTYNLRHRLIFRKVADVKREKELAERRKNEPQLDQNQDHLVRKIFSKFRRDRSQHAAAPPATPSDVEKGDEANDKNMSRVMSTTKLSAVAEKDDSSGGGVKTTVARPATARGSKWGRLLGSASLDSGSETSTVPQAFTRSLSAKDPKERPSSSSSGSSGSQLTPGSGNKIFPKLQKVSATSSPGITRQDTIDEMGEVEPPHSRNLSLRKMQSYDCGLRDPSTASMYQTAVPDAIAPIEYKELMTNLMDFKVDVKLEIQKLNQKLNHVEEMMFELLKRLGPESGSSSQSPNETESKKSSNTPPERPTDLLPRSTEGTGLGSVILKKRRSKTRIKGSAPQVPTPSSGKVTSPDSAATSPTETTKMLDEPVQTPSSRKPKDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGN2</accession>
    <name>A0ABM5IGN2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132353.2">
        <property type="nucleotide sequence ID" value="XM_028276552.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276552.2">
        <property type="protein sequence ID" value="XP_028132353.2"/>
        <property type="gene ID" value="LOC114327847"/>
    </dbReference>
    <dbReference type="GeneID" id="114327847"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF405">
        <property type="entry name" value="PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="9">
        <location>
            <begin position="290"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132353.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="542" mass="60765" checksum="3935A399C7AAB411" modified="2025-10-08" version="1">MEQNGAPKSDNNVYNNKIIIIGAGMAGLSAAYHLTKNNFTDFKILEARGRVGGRIVQIPVGTEKVELGANWIHGVLGNPVYELAMQNGLVDIMAYPKPHKLVAATEQGKQIPFSLLCEVYEAYLCFLKRCEEYFISQYSPPEGIDSVGDHLRLEISLYLDKIKDDQERHLRELIFECLLKRETCISGCDDMNEVDLLELGSYEELQGGNIVLPNGYSSILEPLKNAIPEDNLLVRHPVKTIKWLGKRSSKSTSNTEDSDSDDSDRTVIESLPNSNDSSRESSCEKSLGPKSKVEVICDNGKKFLGEHLICTIPLGVLKHTATTLFQPPLPEYKLEAIDRLLFGTVDKIILEYDRPFLHPSITEVLLLWEAEPEKNSDIQEDWYKKIYSFMKISETVILGWISGKEAEYMETLPNDVIIETCTKVLRKFLNDPFIPKPKSCLCTSWHSQPYTRGSYTSIGVGASQIDIEYLAQPIYDENDKEPVLLFAGEHTHSSFYSTVHGAYLSGRTVAQILMTTDNSEEIVVDCGDATDLSSWVQGICLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJ88</accession>
    <name>A0ABM5IJ88_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134094.2">
        <property type="nucleotide sequence ID" value="XM_028278293.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278293.2">
        <property type="protein sequence ID" value="XP_028134094.2"/>
        <property type="gene ID" value="LOC114329247"/>
    </dbReference>
    <dbReference type="GeneID" id="114329247"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046060687" evidence="1">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134094.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="102" mass="11397" checksum="10F46CC82484327B" modified="2025-10-08" version="1">MKFILLLFLIVSVNARLPSQDNLARSEDDPFTLEDCVSPIELLAYVCEWPPSKYDAWRWDANGAASGCVKEEAHKGCSPTKNNFKSYEECLDIAGPVCGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJI2</accession>
    <name>A0ABM5IJI2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028134252.2">
        <property type="nucleotide sequence ID" value="XM_028278451.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278451.2">
        <property type="protein sequence ID" value="XP_028134252.2"/>
        <property type="gene ID" value="LOC114329375"/>
    </dbReference>
    <dbReference type="GeneID" id="114329375"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16899">
        <property type="entry name" value="LYZ_C_invert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433265" description="lysozyme" evidence="7">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134252.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16629" checksum="5A4395E4D4E52B0F" modified="2025-10-08" version="1">MVVYKAAFILLVLPLAYCRIYDKCTLARELLNVYKFPRWQIPTWICIVEHESHFNTAAINSQTHDNGLFQISQIYWCDPPNHPQGCQVQCSKLRDDDIHDDVTCVKKVYDEFQRTKGNGFKAWTTYDAYCNGNNGGYIKDCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IK90</accession>
    <name>A0ABM5IK90_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134741.2">
        <property type="nucleotide sequence ID" value="XM_028278940.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278940.2">
        <property type="protein sequence ID" value="XP_028134741.2"/>
        <property type="gene ID" value="LOC114329742"/>
    </dbReference>
    <dbReference type="GeneID" id="114329742"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="358"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134741.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="672" mass="76828" checksum="C017F43B4A7A1993" modified="2025-10-08" version="1">MLVNFLKILLNVSVAVLNKYLIFFTVSYWYGKSMTGSSKRKFRLENKKKKMAALIDIVKLNEYDRNQKKKHLNVDENLSVPPVREPSPKRLKTEDSDEDQPTLTSEPPPLIGEGVKPKLEGEAFLELKRMLREKKQKLKNIPTIRLRELGENASLNVELDDRIPLFLSDLQHLVMYSQIGVHAPYLPSRWCALEKYNKLVNTNLIIIENASLYHYMGYESMFPFLSSTFEIKLEMITPGSYNSDIVKDLSMVPLTGTQMKKFTNSFGSLEKAVIKCEEVFDTVKNFFPIMDPEPSEDSTSAHRKLPKTDKFSRTDLLLSGWQMVEENFPLPIKGLMERKYQGYVLTKEKYKDVTSFSPMFAVDCEMCRTSTGDLELTRISCVNEKLEVFYDTLVKPDNEIIDYLTKWSGINKSMMKNVSKKLKDVQEDLQKALPPDAILIGQSLANDLHALKMMHPYIIDTSVIYNLMGDRTRKTKLQTLAREYLKEDIQVSRKGHCSSEDSLACMKLVQLRLRKHLFFGDAVMGGVKNDVRTYPEMGTAQYATSMLRQSVKVDKTANVVGVDELGSKYKFYVDKGEKVDVNNIHCVSGKSNKDVVQLFCDSIKNYSLNIAHLRLADNQLEGNNCKIFKNVDKWIKEIYERSVSPSLLMVLFAGQKEANGVCFLHVKKDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ITC3</accession>
    <name>A0ABM5ITC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141312.2">
        <property type="nucleotide sequence ID" value="XM_028285511.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141313.2">
        <property type="nucleotide sequence ID" value="XM_028285512.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141314.2">
        <property type="nucleotide sequence ID" value="XM_028285513.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141315.2">
        <property type="nucleotide sequence ID" value="XM_028285514.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501997.1">
        <property type="nucleotide sequence ID" value="XM_050646040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501998.1">
        <property type="nucleotide sequence ID" value="XM_050646041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501999.1">
        <property type="nucleotide sequence ID" value="XM_050646042.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285511.2">
        <property type="protein sequence ID" value="XP_028141312.2"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285512.2">
        <property type="protein sequence ID" value="XP_028141313.2"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285513.2">
        <property type="protein sequence ID" value="XP_028141314.2"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285514.2">
        <property type="protein sequence ID" value="XP_028141315.2"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646040.1">
        <property type="protein sequence ID" value="XP_050501997.1"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646041.1">
        <property type="protein sequence ID" value="XP_050501998.1"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646042.1">
        <property type="protein sequence ID" value="XP_050501999.1"/>
        <property type="gene ID" value="LOC114335297"/>
    </dbReference>
    <dbReference type="GeneID" id="114335297"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="8">
        <location>
            <begin position="267"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141314.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="397" mass="44460" checksum="E93B3EC23C7CEF09" modified="2025-10-08" version="1">MFIKINKRAWINLFIFVILSVTIIFMFSDDHVTEISIKTNSEIKEKHAIISYTINNTTKTTATSTSTTTNTATATSISTTPSADIHCYRETSLASLPDISEISPRPGKSIFFHETSCKSFNKGKITINSRQACAVESAARLNPDLDIYVLYSSPGLIKSEGDESDKFLNALQSYKNVKIMHLDYGKYTKGTPVEELYSSGKIEKSQYVVSHASDVLRFLSLWKYGGYYFDLDVVHLKPIQDLPLSFAGVEADVDLGSAALSFSPDGIGHELAEQCLEDLRQSFDGNAWATNGPGVITRVLKKHCNVTQASDWVDKKCVGVTIYPASTFFAIPYQSNELFFDKNFLPLVKDQTKDSYIFHAWNKLSEGHKISVKTDVPYLYFARRYCTKVVAACNQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IX38</accession>
    <name>A0ABM5IX38_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146367.2">
        <property type="nucleotide sequence ID" value="XM_028290566.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290566.2">
        <property type="protein sequence ID" value="XP_028146367.2"/>
        <property type="gene ID" value="LOC114339886"/>
    </dbReference>
    <dbReference type="GeneID" id="114339886"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047001606" evidence="2">
        <location>
            <begin position="25"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146367.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="371" mass="43546" checksum="8F9FB63975D4CFD5" modified="2025-10-08" version="1">MALQILPLLQLVVLFQTTEILSYALPVYGTKRYGRNNQHASTSSYDSYPYQTVVPQHYTEPVSYYKLYPYSDTYHSSYYYPHQSYPLPYYVPSKYKIYQPILPYYYQEHWPSQTYSSYYDYSDPDDFLQETGREEREETQPIGHESYYEDTAEDSNMDDVNAAFLQNLILTQMYQDSLNNKVNADAYDDYDETFAKIEELSKKPTRVPEDENVRELKQLQKAARENGNKKNKQNNNVHWAQANNDHDSKQQRRNKQRKQKQEKQDSKRSNLGANQLLSFPTEDTAIFSERKPILKTFASTLAPSTTDASVINNRGQKEEFQMRPATPIRHPFSAPVLTMMSRSDQDRKRTPSVYDTIKHLLDMEKSFENVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXB3</accession>
    <name>A0ABM5IXB3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146813.2">
        <property type="nucleotide sequence ID" value="XM_028291012.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291012.2">
        <property type="protein sequence ID" value="XP_028146813.2"/>
        <property type="gene ID" value="LOC114340279"/>
    </dbReference>
    <dbReference type="GeneID" id="114340279"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF4">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="553"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146813.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="869" mass="100240" checksum="B797296DC88C3272" modified="2025-10-08" version="1">MDNPSTSIDRYYPGYDPGRKKIDAVRDIVSGIISKKNEIYCPTPEELILDYVLKNKTKYLEKLFNANLLKCRYSHPVYTYYVDILSIACVMEEVKAWTVECLIKMGADIRCRDVDSWEPLHYAALRSDYPVLKDITDELKNRRFHLNEILVDNNNALDILFSYGNKDSVDFVACAKLLIDEGINVNLADNNKITFPSDWANTKKLKDIRKDIQDYYDQITRGTEETVDHEPDQTDPNDCLFELIKKKDEDGFLNYDSAIIVNLADSDNGKMTLLQFACENRTKRIVERLLKVGADKTKTTTIKKETPIEIAADRDYHEIFEILIDQYKENEEIPKYVISEFLPRLLQAYDSPLSKYKSSCDLLLKKLKANRNIYDLNEKTKNTGYTPLHYAARYADTATVIKLVEMGASLDCRNESGFMPVQYLDTEQLEAVLDNCVQGDLSDRKRKIKEFKVSINFSPLLPKKVETKNNNTDPSSASMETNNDIEIQNLDNNNDTTPESINLLNSNNVNKSDNIYETDLVFYMSGVPEFKHLLKHPVVASFLYLKWHSTRWLFWANLAFYLTFCAFLVINVFLNSSIFQYTLLWFILSITLLVLAFREVFQMCLRCKKYFKNVENYMELLLIGLVALILLNCFSTSTQKAISSLSMLLAGLELILMIGQHPNLSTNLVILRTVSYNFFKFLLCYVLLILAFPLSFYIIFAKDPQELSANNTKEDDADPFENPGLSLFQTIVMLTGELNANDLRQNFEKFPIIGRLIFVIFIFMIVIILLNLLNGLAVSDTQMIRNDAELVSYIERVRYLRDIEMIFKDKKHCCLKLLGILKRIAEKSSLTRSKITVLPNQDGQIKEINNLCLDQEIVQRIKNIIRTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IY40</accession>
    <name>A0ABM5IY40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028148605.2">
        <property type="nucleotide sequence ID" value="XM_028292804.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292804.2">
        <property type="protein sequence ID" value="XP_028148605.2"/>
        <property type="gene ID" value="LOC114342006"/>
    </dbReference>
    <dbReference type="GeneID" id="114342006"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148605.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26381" checksum="7E56E5A81A7214B2" modified="2025-10-08" version="1">MFSIHRTTVSRIFYSTLDNLAEATATLVFWPDKLSVRATMPDCFKPNYSNTRVIIECTEFKIDVRSAVDHRVYCYSNYKKGFTLKVLIGITPSGFICFKSPAVGGRKSDSQITIESGLIDLLEEEDVVLADKGFPDIQTVIDSQGKKILLVMPPFLERKKEFSQEETEQTYTIARVRIHVERIMQRLKTYNILNKIPEYLFDNVDDIIHICCVLVNLQPPIFAEKSENNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH69</accession>
    <name>A0ABM5JH69_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 6a14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497283.1">
        <property type="nucleotide sequence ID" value="XM_050641326.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641326.1">
        <property type="protein sequence ID" value="XP_050497283.1"/>
        <property type="gene ID" value="LOC126878549"/>
    </dbReference>
    <dbReference type="GeneID" id="126878549"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045511709" description="Cytochrome P450 6a14" evidence="14">
        <location>
            <begin position="18"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="118735" checksum="59BECF1EB11A3DF8" modified="2025-10-08" version="1">MFLLLILLLPLVIFVYQKWHYSYWKRRGVYQVEPNFLYGNLKEFANGNLCISDELKNLYDEFKSKGLLYGGYYAFTKPTFMPIDVNIVKHILQKDFGHFVNRGIYFNKERCPLSAHLFTLEGEKWKTLRAKLTPTFTTGKMKMMFPIMVACSENLTDVLKKDVTLQDAVDIKEIIARFTTDIVISAAFGIECDSLKNPDTDFRKYGRRVFEAGKWEQLKRQMSNSVPSWILDAIRINILDPETEEFFMKAVRSTVRYREENNVYRNDFIQLLLQLRNKGKISDDHDITLVDKNDDSRHFLSLEEVAAQSFAYFIGGFETSATAGAFTMLELAMNLEVQDKLRNEINTVLEKYDDKITYEGIMEMTYLDKIVHEALRMHPTASEIGRICNSEYKIPGTDIVIEKGVRVIVPILALHKNPDHYPDPDMFDPERFNEENKAKRHPFAYIPFGEGPRMCIATRWGLLQTKVGIVAIIKDFSVTLNKKTQLPIKYAPKAVVTSVAGGIWLDLQSLQSMLVFLLVILVAFFYLYKKWIYTYWKRRGVYQMKPEFFYGNFKPMTTGKMSVAELIREIYTEIKAKGGQYGGFYQVFKPGFMPVDLDIIKGIVQKDFGHFMNHGNYTNPEVDPLSNHLFAMEGEEWRKMRSKLTPTFTTGKMKMMFPTMVACTQGLNEMLKDHASIQDAVDIKDLIARFTTDIIGSAAFGIDCNSLQDPNSDFRQFGKQVFEVTFWKRLKRLISTNLPKWLLDLIRLKMVDQALEDFFMGIVRSTIKFREQNNVYRRDFLHLMLQLKNKGKVTEDKDFKPVDEGLETTRENDDNFLTFNEVAAQCFVFFIAGFETSSTTISFALLELSKNPEIQDKLREEIRSVLKKHNNEFTYDAIMEMKYLDKVVNETLRIHPPASAIARICNTDYKVPNTDLIIKNGIKILVPIIGIHTDPDHYPNPNVFDPERFNEENKAKRHQFAFIPFGEGPRMCIGSRFGLLQSKVGISSIIKDFAVSLHQKTKLPIKYSPKSIISAVEGDVWLTVQLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI94</accession>
    <name>A0ABM5JI94_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497663.1">
        <property type="nucleotide sequence ID" value="XM_050641706.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497664.1">
        <property type="nucleotide sequence ID" value="XM_050641707.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497665.1">
        <property type="nucleotide sequence ID" value="XM_050641708.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497666.1">
        <property type="nucleotide sequence ID" value="XM_050641709.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497667.1">
        <property type="nucleotide sequence ID" value="XM_050641710.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497668.1">
        <property type="nucleotide sequence ID" value="XM_050641711.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641706.1">
        <property type="protein sequence ID" value="XP_050497663.1"/>
        <property type="gene ID" value="LOC114336930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641707.1">
        <property type="protein sequence ID" value="XP_050497664.1"/>
        <property type="gene ID" value="LOC114336930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641708.1">
        <property type="protein sequence ID" value="XP_050497665.1"/>
        <property type="gene ID" value="LOC114336930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641709.1">
        <property type="protein sequence ID" value="XP_050497666.1"/>
        <property type="gene ID" value="LOC114336930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641710.1">
        <property type="protein sequence ID" value="XP_050497667.1"/>
        <property type="gene ID" value="LOC114336930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641711.1">
        <property type="protein sequence ID" value="XP_050497668.1"/>
        <property type="gene ID" value="LOC114336930"/>
    </dbReference>
    <dbReference type="GeneID" id="114336930"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17398">
        <property type="entry name" value="MFS_FLVCR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="461" mass="50867" checksum="F713B15142D8E193" modified="2025-10-08" version="1">MNSGDVDFSKQLPTIERIQVYGIRWIVLGIFVFYSAVNAMQWIQFSIINDVVVKYYGISSMWVDWTSIIYMVLYVPFVFPASYLLEKLGLRKFVIIGMLLTCIGSWIKVGAVHPDRFYIAFIGQTVAGFAQIFILSVPARLAAVWFGPSQVSSACSIGVFGNQLGVALGFLLPPIFVSADSTIDQMTHDFYVMFISVGAFTTLLLVIIILFFKDKPPTPPSHAALQQESETIDFMNSLKDLCKNKSFVFLLVAYGINVGVFYAISTLLNQIVLLYYPGASADAGRIGLVIVVAGMLGSVCCGIILDKYHKFKETTLVVYGFSLVGMVIFTFTISKGIYVVYIISGLLGFFMTGLLPVGFELAAELTYPAPEGTSAGLLNCACNLFGIAFTNIYSIILNHVGDQWANISTSIALVLGTILIACTRSDLRRQAAHSEKNDEFSNERQRLLINQSEDINYTEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIN2</accession>
    <name>A0ABM5JIN2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Angiomotin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the angiomotin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497789.1">
        <property type="nucleotide sequence ID" value="XM_050641832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497790.1">
        <property type="nucleotide sequence ID" value="XM_050641833.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641832.1">
        <property type="protein sequence ID" value="XP_050497789.1"/>
        <property type="gene ID" value="LOC114347035"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641833.1">
        <property type="protein sequence ID" value="XP_050497790.1"/>
        <property type="gene ID" value="LOC114347035"/>
    </dbReference>
    <dbReference type="GeneID" id="114347035"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009114">
        <property type="entry name" value="Angiomotin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051747">
        <property type="entry name" value="Angiomotin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024646">
        <property type="entry name" value="Angiomotin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826">
        <property type="entry name" value="ANGIOMOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826:SF14">
        <property type="entry name" value="ANGIOMOTIN_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12240">
        <property type="entry name" value="Angiomotin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01807">
        <property type="entry name" value="ANGIOMOTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Angiomotin C-terminal" evidence="8">
        <location>
            <begin position="453"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="782"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="929" mass="103979" checksum="358FFA25774610EF" modified="2025-10-08" version="1">MQSNNRYRSFKQLGQGNFPKSLSGSETDVSTSNENLSNEEKYVIRHTPRQEPQGQENLTDSKRSSLRDSLPSNRSSLDVSSSSYNTLIIHSAGDEPWNGRNSGPREGSNISSNYIIHQSSNLSNDPKLSPLIKRSSTSPSPSISSTGVQEITAIPDDYLNQSSVLKHLAKEVKVPSSPVGTALESNLENLVLFELNALPSPPDYLKWSEKSPLQRKVENRNKINVEKLTLSKSQPDLSTVGVIKSDDNLFRRGVSAPRPPTKGREENESKGEEIWPSAEMVEILIKENSALKQELENLYQRVERTQRLEHEILKVHKGHEELVQSCERREILERAARARLQSDCVRYQELNKALREQVELLSTQILSRSPVPDYGVPENLRRELAKREGLIKQLISQNKELSAAKERQEIELAAQRATLQEQRTHIDILDTALTNAQGNVVRLEEECRKKQVYVERVFQLQRALSSMQMASERREQTEKKLRLQLERELQRAKSAQGGWDSPNGSGSESASELKRMLREKDERIMTLEGECSRWEQRFLEESTLRQAAIDAASIPKDAKIAALEKTSQETEKIIAEARNEKIRHMDEVHAAQKKVADLESRVKDLESKLAEKDAMIRVLQKHTYEKDMTSMLGRSPLHTPHPSLAGPDIDHVLGTTVSREELVSSVLTNSTAYGSSNSYAGSDSSYHMPSYTKYESSQTYDSTKQKLDNQLKEIDSQLDSQLLSKRALCCFPGFTNPVTAQRKGKIPKPLLAGVTTVSYEQGPFLLPPTRHESGEMLLLEKQGRTSQQQRMPEGVQATSQKPPTPSSLPRPPRSSLRSGLPRRLGEYNRLPDSEKKSDGGDSLSSNSSSRRTSPARSLILPPRKLGEYGRLRSSSAGVERDSVSTVSDNSASSSKVRLYGGGSLRRGSSLGRDSKCSSDCATNKYRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIT9</accession>
    <name>A0ABM5JIT9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497853.1">
        <property type="nucleotide sequence ID" value="XM_050641896.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641896.1">
        <property type="protein sequence ID" value="XP_050497853.1"/>
        <property type="gene ID" value="LOC126879016"/>
    </dbReference>
    <dbReference type="GeneID" id="126879016"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="186"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="655" mass="74807" checksum="2AFDFB0C2FB054E7" modified="2025-10-08" version="1">MFRKGLSEDELRRLAEESDFSDSSMSESTFYDSDADPVYNENVTDGSSDSYSSEYESRRKKAKICKQTQNCKEFTAGSSSNQKEADTRRIEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVVSRNKITWSDVPNPDDLNKFELSFTSGISQEELAKLTDHKPIDFYLLFIDRQVQDLLVTETNKYAEQTIIAGIVNESITKHSLMSNWRPIDRKELLRFLALIIWMGLDRKPKLRNYWSNNLLYKNEVSKMCEISRSRFEILLHFFHISDNESCPPGNRLYKISPLVQILNEKFQKMCTPRESLCIDETMVPFRGRLSFLQYIPGKRHKYGVKLFKLCVADGYTYAVKVYGGKEMQPSEKSLASRVVMELMQPLLDTGRSLYTDNFYTSVDLAHDLNNRKTHLVGTLRSNRKHNPKAVVNAKLKRGDMKYLQSNTKVVIGKWKDKRDVLFLTTKDIPLMIDVQTKRGPVPKPSTIVDYNSAKSFIDVSDQKAAYNSPVRRSMKWYRKLAVELLTNTALVNSLVLYKSVTGKHLSITEFREQIVQSLLMPQTTSENSLTTSENSLTTLHTLDEKEKRGRCSACYKNFSNREGRASAMKNAKRVYTFCPACAVNTAYMCVKCFVNIHTCSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ88</accession>
    <name>A0ABM5JJ88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498007.1">
        <property type="nucleotide sequence ID" value="XM_050642050.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642050.1">
        <property type="protein sequence ID" value="XP_050498007.1"/>
        <property type="gene ID" value="LOC126879106"/>
    </dbReference>
    <dbReference type="GeneID" id="126879106"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="356" mass="39540" checksum="4D6D222CE9A27FFD" modified="2025-10-08" version="1">MSLVCIDDYEKYAQEKLPKIIYEFFQSGAGRELSLKWNRTSFSRYRIRPRYMKKVDVRNLSTNVLGKPVSIPIGISPVAFHKLAHSDGECGSVKAAEDNQTIFILSSHSNSYIDEVARAAPNARKWLQLYIFQKRSITQDLIQEAESNGFEAIVLTVDFVAFGLRLVNIRNKFKLPPNLCSALLKKYQNNNVLNSLVDISDPTADWNYIKWLKTITNLPIVVKGILTAEDAVLAVEAGVSAILVSNHGARQLDTVPASIEVLPEIVQAVGSRVDVYMDGGIRDGTDIFKALALGAKMVFVGRPIIWGLNHDGEKGGKKILGILKRELDNVMALTGCTSISEINKDVVIHESFYSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK58</accession>
    <name>A0ABM5JK58_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neuropeptide-like 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498324.1">
        <property type="nucleotide sequence ID" value="XM_050642367.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642367.1">
        <property type="protein sequence ID" value="XP_050498324.1"/>
        <property type="gene ID" value="LOC126879300"/>
    </dbReference>
    <dbReference type="GeneID" id="126879300"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175542" description="Neuropeptide-like 3" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="8770" checksum="ECA584E22D941EB5" modified="2025-10-08" version="1">MFKLCFVAALLGIAVTVPAPEPKPAPKADPKAQFLAAPVVAAPSVAYSSAYVDAPLAYSSYAAPAVFPGAYSVYPQYSASYVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMC1</accession>
    <name>A0ABM5JMC1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499087.1">
        <property type="nucleotide sequence ID" value="XM_050643130.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643130.1">
        <property type="protein sequence ID" value="XP_050499087.1"/>
        <property type="gene ID" value="LOC114328528"/>
    </dbReference>
    <dbReference type="GeneID" id="114328528"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="531" mass="62333" checksum="331E0490BE1E372E" modified="2025-10-08" version="1">MCSNVTALDFPRICRLCLKKEYSRDIFEVPEYLTLIQNITNLKVQENDGFPTNICQHCLNKLGDISEFVQMCVGNYDVLLRIHENNKIKTELLETTLNTSVMLKAENGNDSDVSLKSDLCYPDQVYSDSENEEPKPKQVTCKLCQKSFKTWYKLQVHQKKGCPMADVKTVAYICLICDWEGGTKSALRNHERKEHTEIVEISEGVSKKKWKCAICCKLFTKKIDLQRHRRVHTGLRPFICVLCEKGFTQKSTLERHMSSLHSNQEEKYNFECYICERKFVRKDHLEAHMHNVHIKRQNDEPLEIEYYTSSKSCKLCSKSFSIFSYLHNHLMIVHEETKPPKPKPREKKIKFEHSSNLCSICGKSFEKRKTYQMHMNRKHSEKKYEQKPRKVVAKRDKFQCWHCGKIFTTQSNLTVHIRIHTGEKPYQCGFCAQKFAAYSSWHEHENIHTGKKPFQCVHCKKAFKQRGSLRKHMRSSVHRKPVEELISPEVHNIRQMNSLENNVKEDFMQANENVRQIQIAHSVLNCSNSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JND3</accession>
    <name>A0ABM5JND3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499448.1">
        <property type="nucleotide sequence ID" value="XM_050643491.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643491.1">
        <property type="protein sequence ID" value="XP_050499448.1"/>
        <property type="gene ID" value="LOC126879993"/>
    </dbReference>
    <dbReference type="GeneID" id="126879993"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
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            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
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            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="532" mass="60655" checksum="535BED38797A379B" modified="2025-10-08" version="1">MSGYKRVSFYELCRLCASNTQKEKTHIFNEEGRKIQLQDKIQACLALTVNEDDSLPKVVCSKCLRTLETCFGFRQECVRSESMLSTYFKNFRYTDDFKKSGKVYIKDIKSSPVIQSVLAPIPPVPTTHIQAAPQSIAVNKAPQNIEQVPFYTLQLPAIVSNPNIVNKAQKCTEPQKTTQNQFAYNLNLLNTTSIKANLPKTEILSNVVVNSHGEVLNISHLGEFEAILNQENSMKIKNKQIKRKDTNSVQNTVVQIDLTESDNSEFDTEAKFDKLPHIKSTHNHDKYSYPNKVEEKPPNETVIFPISEYSQSFNNFNSANVVYSQPNLSLITTSSTNTNVISNTSAALDNPSLNLINQNLQEITPPSYTNVISTHVPPEIENSKTDMDQNDHISETVNTAQLNSSTVPVKTHVCEICQRAFKRKEHLYQHVKLHTGFRPYICEHCNKAFMRKEHLLRHSSLHSGQKNFVCTICDKSFSRNDNLLKHKKTHDKQASYTCEICQKQFVMKHYFNAHKLTHDKYFVSTVWGLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ32</accession>
    <name>A0ABM5JQ32_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500044.1">
        <property type="nucleotide sequence ID" value="XM_050644087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500048.1">
        <property type="nucleotide sequence ID" value="XM_050644091.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644087.1">
        <property type="protein sequence ID" value="XP_050500044.1"/>
        <property type="gene ID" value="LOC114333771"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644091.1">
        <property type="protein sequence ID" value="XP_050500048.1"/>
        <property type="gene ID" value="LOC114333771"/>
    </dbReference>
    <dbReference type="GeneID" id="114333771"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="151"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="406"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="751"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1256" mass="142497" checksum="850A01A836D2640B" modified="2025-10-08" version="1">MDSSKIKKRRLNPRDSANIWSLVTFSYITDLLKRGVQKDLKEEDLYEVSKNCASKHCAEQIEKKWKKGKKDGKYPSLFLTLCKVFGWKYFLWGITQLFCELFRSIFEPNAITNLVSYFQPGQTKLSKSDAYFNAAILLFSNFLQKIYFFNYDLFLFIMGIQVRTALCSLLFRKVLKLSPAAMTKASLGNIVTLITKDVQQIRRSMFAFNDIWVFTVVISVTCYLLYARLGVLTFFAVGMHFCIIPIEFFLGKMVTKMRNETSEMTDERIQVSQEVLSATKIIKMYTWEDYFYQKINLARTREVAKMVIVFYLRMILMLLGAISTKIGFYLMIMGYIWMEQPPDASIIFFITAHYDNIVIFFGYLLPEAVGRFAELSVTIKRVNRVLIAEELDQDHQSKQNNVKPYVELKNITVCVGKEEVLSKISFKVDSGLTLVTGKVGSSKSTLLKAILQEYPLSSGEVVCSGTVSYASQHPWCFPSTIKQNILFGEKYNEKRYQEVLKVCALEYDLNLFEKGDETILTDNGQNLSKGQQARVNLSRAIYRQADIYLLDDCLSALDAHVHKFIFKKCIKEFLKEKICILVTQSKSTLTQADAVYVLDKGHIIGSYNPQENTEKEVNNFADTIYKTKEFLIKENGLMESMEVDRFLETEQSNYKNIYEEEMKKGAVDKSVYIKYISYGGGAALFTFALLLIGSKQAAESYSEKLISVWSDDKQKVLNIKANISNIIGQNITQLSTNLTQAEVQAASTFQMYTVMVILSLVLELLKTFAFLDFCKRASINIHKAMIKNVLHSVMAFFDTHFIGNILNRFSQDVINVDENLPFQLLNCLEVAINVGAAATLLMTVNPYFFFYISVTFGVMLLFLKLYLPITRNLRRLEASTRSPMIGHLNAALEGVTTVRAYKAENMIIDEYERHQDVFTSAHYSLLCFKFGMGFYMSMLAGVMVTLVICSFVLFETDATAGSIGLALTQVIYLGALIQGAVRCWADLETLMTATERALEYTGLKSETTQGSVPKHWPKDGTISFQNVSLSYNSTQRILNNLSFQVQAKEKIGIVGRTGAGKSSIISTIFRLYEVDGKITIDGVDIKLLPLKHLRKHLAIIPQDPILFSGTIRSNLDPFGEFQEKDLWEALEKANLKTSITNLDIKVSSYASNFSLGQKQMVCLARAILIKSKIVILDEATSTMDHETENLIQETIKHNFSDSTVLTIAHRLQSILECDKVLVLDRGQIKEFGTPKELLENKIGHFSKMVAQGDMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSR6</accession>
    <name>A0ABM5JSR6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pao retrotransposon peptidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500970.1">
        <property type="nucleotide sequence ID" value="XM_050645013.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645013.1">
        <property type="protein sequence ID" value="XP_050500970.1"/>
        <property type="gene ID" value="LOC126880937"/>
    </dbReference>
    <dbReference type="GeneID" id="126880937"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44508" checksum="85E7B587C74AE02D" modified="2025-10-08" version="1">MYVDGFISSFPNDSDAIVAHTQLVNLFQKGGFKLTKWMSNSNDLLSTIPEPLQLVKTKQFDKSVSKVLGLQWEAKCDNFSFGLEIPSSTHCTKRNMLSRVARMFDPLGFLSPITFLLKIWMKKLWTLKLDWDSTVPKEIEIAREKFQNEFHVLCKIQIPRHISVTPNSSLSFVGFSDASAAGYAATVYSRVVNCTGQVRVTLLYSQSKVSPMSKITLSRLELCGALLLSKLLSHALETYSPRHNIDKIFALSDSMIVLNWIKSSEKNLKLFVQNRVVTIHKMVPSLYWFFVPGKENVVDCASRGLFPSSLVNHPTSFTGPNWLLLEPEYWPIQSVNGQEIIICDSEYRSQTFFGNVTRVISPLYTLIEYFSSWSKLLHSTVYVLRFLKNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTQ0</accession>
    <name>A0ABM5JTQ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Growth arrest-specific protein 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501315.1">
        <property type="nucleotide sequence ID" value="XM_050645358.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645358.1">
        <property type="protein sequence ID" value="XP_050501315.1"/>
        <property type="gene ID" value="LOC126881222"/>
    </dbReference>
    <dbReference type="GeneID" id="126881222"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039308">
        <property type="entry name" value="GAS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025593">
        <property type="entry name" value="GAS8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31543:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13851">
        <property type="entry name" value="GAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Growth arrest-specific protein 8" evidence="14">
        <location>
            <begin position="215"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="242"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="470" mass="55243" checksum="BF4024B7485ADEA6" modified="2025-10-08" version="1">MPPKKGGGPKIIDGVDTTSMTREQLEAFAQRIKEENDREREERNFFQMERDKIRTFWEITRNELEEARAQVRNKDRALEEGVEKNEEELKFFKQKVKHLQYEHQNNLTECKAESLVALKQAQDEHTVQERQLLEDKKNLKAQMREKELSNQEQIKSLKIQNSEEISKARSEFEIRAKEMEMKYEKKYADLRAHLNNKHDMEISEVEERKNEHISNLIKHHEKAFNEMKNYYNDITLNNLALISSLKDQMEILRKQNERMTKQVADLTAENKRLVNPLNAALAQIKEYKRQLENYERDKQALANTKLMLSQKIKALDDLRWSYDALELRFETLQKERDELHNRFVQAVLEVQQKTSVKNLLLNKRISTLTQVAEHREIVIAELQAATKTPPQRTNQKLEEILTKKNATISDLQYELARVCKAHDDLLETFEEKLQQYGIPKQELGFIPLRIIPEGQGGLATGPAGLVTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVW0</accession>
    <name>A0ABM5JVW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rogdi</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502075.1">
        <property type="nucleotide sequence ID" value="XM_050646118.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646118.1">
        <property type="protein sequence ID" value="XP_050502075.1"/>
        <property type="gene ID" value="LOC126881705"/>
    </dbReference>
    <dbReference type="GeneID" id="126881705"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30321" checksum="4CA677A8C28820E9" modified="2025-10-08" version="1">MTDCEKEEATNLQKEFEWVLNQEVHKGLEQIHQILVECARRFPVALYGHDNSSKQDKFVLSVPADQLKCVVTLTGDSITHADINFKVVRQTNTTMVRTTIQSEYPWKLQQVQDAANHLQQAIYHIDDVGKNYKFKSSDEVLHVLGNILGSLQRGRTSLIVPRKKTIYDLLKSRNMKSLAPPLAEDLAISFYIQSHKLVFVMYHLMNNQGVMTPDSTPAECSVPWLNEVLVLFTVGLQLCQQLKDKICVFSQYKDFTVGSRPASPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0E9</accession>
    <name>A0ABM5K0E9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503659.1">
        <property type="nucleotide sequence ID" value="XM_050647702.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647702.1">
        <property type="protein sequence ID" value="XP_050503659.1"/>
        <property type="gene ID" value="LOC126882718"/>
    </dbReference>
    <dbReference type="GeneID" id="126882718"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="118" mass="13795" checksum="8F53CB30173DDAD7" modified="2025-10-08" version="1">MENKSAQYKYCIVPGCKSTTVRTSNKHFFTLPKEPKRRLKWLKACRRDKKDISQKSIGLYVCEDHFDLEQDMDNYIKFKIMGGPKIIKSGVVPHIFDCQPDRKRAYSQPVREAALKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0I4</accession>
    <name>A0ABM5K0I4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503694.1">
        <property type="nucleotide sequence ID" value="XM_050647737.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647737.1">
        <property type="protein sequence ID" value="XP_050503694.1"/>
        <property type="gene ID" value="LOC114328300"/>
    </dbReference>
    <dbReference type="GeneID" id="114328300"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15294">
        <property type="entry name" value="7tmC_GABA-B-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045038148" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="455"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="883"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1184" mass="136418" checksum="C09FB2BCC93C4B18" modified="2025-10-08" version="1">MIRFAVYTVLLLLIFLKCCNFQKPNMDNKRHDVYVAGFFPYGRGVENSDTGRGVMPSVKLALDHVNEHSSILRNYRLHMWWNDTMCNAAVGVKAFFDMMHSGPHKLMLFGAACTHVTDPIAKASKHWHLTQLSYADTHPMFTKENFPNFFRIVPSENAFNAPRLSLLKEFNWTKVGTIYQNEPRYSLAHNRLVAELDTMGYQVLETQSFTNEVLSALTKLKEKDTRIILGNFNEIWARDIFCEAYKLKMYGKKYQWIIMGTYSPGWWTRLDPDFNCTLEELESALQQTILTDLLPLSTSGEITISGITADEYNQEYETRKGDEYSRFHGYTYDGIWALALAIQNVAHKIKYFRRNESVVDFRYRDPIWEKLFLDALHNTSFEGVTGPVRFYDNERKASILLKQFQEGKEVKVGEYSAATQHLDLTLGDPLKWIGKYPPKDRTLVIIEHTRVNKTVYAILATLAVCGIIMAIVFLAFNIKYRNQRYIKMSSPQLNNLIIIGCMLTYTSIIFLGLDSGLSSIDAFPYICTARAWTLMAGFSLAFGAMFSKTWRVHSIFTDVKLNKKVIKDYQLFMVVGVLLVIDLAIMTTWQIADPFYRDTKQMERYQHPSNEDIIIIPENEYCASEHQTIFVGSIYAYKGLLMIFGAFLAWETRHVSIPALNDSRHVGLSVYNVAIMCICGAAVALVLVDHQDAMFLIIGVFVMFCTTATLWLVFVPKLLELRRNPAGAIDKRFRPTLRPMSKTRRDSSVSELETKIKDVKSLNSKYRKTLLDKESELQMLIRRLGNEAKELLESRADSMSDTNRLSVPLLRKEAPSATETSDLTSLCSLSSQDYATLQRNDSQKQVINFLYLYLLILERLKNYTKYVNTFFVYSQMGNHNHHKIKKKKILGESPKRAKSPVPTLQEPQPEPQKHLNGTVKQNNETSELDSNYNSVKEIPKDSKPEYDKPPDYQPVEYPKEEYVRTKTPTHERRSSRCYDSETMTITRRKSSLKAETVVEQEERTCHKTAVPSNRTTPKKKPEYGTHVVSKSELWDTGSQHRCMKSHQKNSRVSISQEEDDPHMHRTVSERNRHSSQRDKRDKSPAKKQQEPQQLPTNICNQQCNKLGYFQSTPNVNSLKNPAHTPKREKSMYNATSESELLDREILPIFQKLLTERNKSQHNIDISFGRSCPNISIKCDIVEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1A2</accession>
    <name>A0ABM5K1A2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase APD1-4 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503960.1">
        <property type="nucleotide sequence ID" value="XM_050648003.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503961.1">
        <property type="nucleotide sequence ID" value="XM_050648004.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648003.1">
        <property type="protein sequence ID" value="XP_050503960.1"/>
        <property type="gene ID" value="LOC126882928"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648004.1">
        <property type="protein sequence ID" value="XP_050503961.1"/>
        <property type="gene ID" value="LOC126882928"/>
    </dbReference>
    <dbReference type="GeneID" id="126882928"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 middle" evidence="3">
        <location>
            <begin position="447"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64657" checksum="B7B931DBDE4FBEC4" modified="2025-10-08" version="1">MREESIYEFPVLQNSSLYQRRISTNPWILPVKVIKLFILGILVPCLLITIPLYLRYRVYSHQMYPLAMSDMRLIDNKVSTTWCQRQRVSVNATFNAFLLSKTPEMSTDKKPMSMVRELSLEDDTKEYWGFYLLKGTSVTVSTCVRWPGASLIMIRGHKHLHECAYIGDNSSEELEEQMEAIRENAFVDSDEKKADQPANNPEEMKRHRPEVKFHSEMQQNYSKRLEQSIDNIEVTDWKDMRAVLLALQEKSKNYKSKLPQLNKQHVHRNSTIAVDETKNFKIDKPKNQTSSEEALDDIMSRLTKMGEKGTRVLEKVNNKYMSKPKEHVLDIKARHYSKPAVVFENVDQARKKRELVLEQALANNEDDEEHDLALEEEFHPDGIADHRGTFNETSLNDMSNSEFWSSFSSSEEALLNCAGLILSLPLLPHRKCVREYVDEESSRDNTISYKVPLNGYYFFVFNSENEVQTNYVRVQFDIEKTVYNISNPVAECINASDTCTVDLNFFSSEKLVMELPLVDNESLFNEEYIVLSECEPRSSVYAVFVILVPILVIFFAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2X8</accession>
    <name>A0ABM5K2X8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504546.1">
        <property type="nucleotide sequence ID" value="XM_050648589.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648589.1">
        <property type="protein sequence ID" value="XP_050504546.1"/>
        <property type="gene ID" value="LOC114333464"/>
    </dbReference>
    <dbReference type="GeneID" id="114333464"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116071" checksum="BA3067D0E8160DA8" modified="2025-10-08" version="1">MVNYVLSFCKITGASKIFKRHFYLPLLKPQNPKEALRTLRITGKWLLGAKIQRYIPVLLNHSQKRPRKSKQFGKLSHSKSSDFTYMTPNLDPDNENHKILLKILEKGKDKNGYFTYTVDDKKYNIVFESNFENAILNGDIIDILVSQKNDKILIKLKDKKKIPIEIQYFEGNSDELICGEGATTPAEEKQHHYGKYTMGLAKMFEEKELREEKWEEELKKILKRRKKQKWENSKAYKEMMKRTMKNLDWNKFEDEAKKLIDDISEPTTEIPIEMDVDDLESTKNVAETILNRGPEALNQLPTITEIPDLIKSMGNAELAEIEDIPSEENQKRRRVSGVKVTLPSGKECFVSGQMVLTEEGEVFVPGQTVHNEYGDEYVPGITTNVDNKPTLIGGLIMGEDQKDPMFLPSQAAITSDGQLTFATTAEERPPPQPESERKVKRRKKPEPVIVEEEPLPLEIIIVEEISDPSDSDDKSTRASSVELNSSEIEELDMEAIRIKQEKHRQEMEELKMQLFDNMDGIIANLEDKKAQLKKKLEDLRRQHMDNQNNLVSYVNEKDALEIATKISDDPETINRLVDILLTMTRRASTFRDKNSVRADNIDLSYLSTNASDAEIKLHSCSNKLKILFKSALVAANDVFKNRPKDQVLALHAMGEILVETMKHDIKLILEMTNLMKTQFDRDEICDTAFKQLIRVIEDTKICTLAMIVDKHMSIPDLIESIEKVLGQDNMMHTAFAKILKINSVVVNFLIENLEELVKEVASEEDAVRVLQRSIVSAIRTLMDFNLEQAKKKSSYVDLIEEASSFAKALGRDDVVEDLSNPSQEFVLEDSTNMLKRMTLIKQLSERDYSLKTAITRIKKNPECAKSDPRIRQLVRESAVLISNPSPLLTSRSIPLQIMKKQNLLAIEDYLVKRTNLEFPVLISRGTHQAVIPKDASRGVLAGRVPYVLIDETGVTNFKPMHMMSAIHVNKNREKRIDDYLSAVPESDFSTSLHAKSNGSDNSRGTMSSSALLRGYGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K433</accession>
    <name>A0ABM5K433_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504946.1">
        <property type="nucleotide sequence ID" value="XM_050648989.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648989.1">
        <property type="protein sequence ID" value="XP_050504946.1"/>
        <property type="gene ID" value="LOC126883442"/>
    </dbReference>
    <dbReference type="GeneID" id="126883442"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="164" mass="18941" checksum="9ABD972022D3F7A5" modified="2025-10-08" version="1">MYADDVVLVGNSERDLEQKLEQWRHALEEKGLKVSRTKTEYLECSFKDGATTNKMVSLDGEMIVKSNSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVAEMRMLRWMSGVTKKDKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4Y7</accession>
    <name>A0ABM5K4Y7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505256.1">
        <property type="nucleotide sequence ID" value="XM_050649299.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649299.1">
        <property type="protein sequence ID" value="XP_050505256.1"/>
        <property type="gene ID" value="LOC126883644"/>
    </dbReference>
    <dbReference type="GeneID" id="126883644"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42675" checksum="893711D1FA08F8DF" modified="2025-10-08" version="1">MPITNADISSLCATLPEFTAGQNLSTFIKSVDNLLIFLQQQNTTAPQEFIINAHILSRIKGEPRDYLNYSNKTNWTDVRPALLTKYGDRRSEEILVTQLTTTVQKASESYDDYHHRIIDNLNDLLQHISLHNTPENLNFKTPYFRKLALKTFCTGLNNPYCEHLSHFQLDSLDEALQKCIALDNHKNQVSYMNFLKSQQKTEKPKTNNSFPTAFKSNFNARAPNNFSNNQFRPYAQNISNFSNQRNQFIPQNPNFHNNNSRPAFTSNNSNNYRNNFANNRTPYRSPMLRHQQVNTPTPMSGVQSINTETRPMTISTQNFNVETDYYNEPHTQHNNVDEEFTDNSVSDEPSKYVEQNFHDLSLDEHPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K538</accession>
    <name>A0ABM5K538_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M10 metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505306.1">
        <property type="nucleotide sequence ID" value="XM_050649349.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649349.1">
        <property type="protein sequence ID" value="XP_050505306.1"/>
        <property type="gene ID" value="LOC126883688"/>
    </dbReference>
    <dbReference type="GeneID" id="126883688"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M10 metallopeptidase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="326" mass="37435" checksum="BFF731032818B041" modified="2025-10-08" version="1">MVILHEIGHSLGLSHSNDKNAVMYPWYSYKLLTITQDDINGMEALYGRKSTYITTQQTSASTQATPRKSTSYIPTQASTSTRSHKSRVHTTRPRPIPTEIIPHHTTKTAPPFCAIEYPNILFLAYDPQFKNHHMYIIHDGFVWKNDLNGHMVPNNPEHLSTYVPKQIRNISYVFQNTAGNLILTSNNTMYSVSFPSITISRDIPLFILPPHAEINVVFQTHTGKTYIWYDNTSFIEYDDIIDLVISRGLIKDIFPGVPTTVKSVFKYIDGHLYFLDGSTYYKYNEFTKKIIEIGRFNWNLFGIPCPDDSLITQLKYLLNKVGSFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7J1</accession>
    <name>A0ABM5K7J1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506159.1">
        <property type="nucleotide sequence ID" value="XM_050650202.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650202.1">
        <property type="protein sequence ID" value="XP_050506159.1"/>
        <property type="gene ID" value="LOC126884267"/>
    </dbReference>
    <dbReference type="GeneID" id="126884267"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="66"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="370" mass="42910" checksum="FEA3878CE5CFD448" modified="2025-10-08" version="1">MSPLHNNLALEQTTNSFVSTQKSTEQIKRNGYFDQDLVWKNIILYLIFHSLVLWGYSRLFTGKLMWTTFIFMHIYAYLSVIGITCGVHRLWSHKAYKAKLPLRIILMLMQTATLQNNIYIWTRDHRLHHKYTDTDADPHNSNRGFFFSHVGWLLMKKHPEVKSKGKTIDMSDVAADPVVQFQKKYYLPLALSLGLIIPTVFSTYILGESLTNSCLGSIMKSVYILNGSWMINSAGHMWGWKPYDRTINPCENLTIAIITWGEGWHNYHHTFPWDYKAAELGNYRWNVSTGFLDLMAYLGQAYDLKTVSPEMVRKRVARTGDGSYKHGKVPLENGNAKVQHNFHEDCVWGWDDKDMKEEDIKNATIMFKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K880</accession>
    <name>A0ABM5K880_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase A2</fullName>
            <ecNumber evidence="2">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050506396.1">
        <property type="nucleotide sequence ID" value="XM_050650439.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650439.1">
        <property type="protein sequence ID" value="XP_050506396.1"/>
        <property type="gene ID" value="LOC114335054"/>
    </dbReference>
    <dbReference type="GeneID" id="114335054"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045586503" description="phospholipase A2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="7">
        <location>
            <begin position="191"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="255" mass="29917" checksum="BFE7286FE7862E98" modified="2025-10-08" version="1">MRCVKKGRPRCIGHLLVAIVCGLALTGVTCSVDETSSQEITDFVSTNVLPDGEVETRVYYKGLSAKETRVARGSKFGLKFRQLTRTNHFIQLIYDDDDQLIDCEFGHDQNQTKTFLSSFKRDLSNLITTSNLTVESLDGKELPRAFLWMNYSHLRDDCKHRHRELRQNIKKERVFLDNQRFPKRSKRSIFILPGTNWCGDRNRARKYTDVGSMMLTDRCCRRHDFCKMDIPGMTKKYNYFNYRLFTLSHCRCDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA24</accession>
    <name>A0ABM5KA24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136093.2">
        <property type="nucleotide sequence ID" value="XM_028280292.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143425.2">
        <property type="nucleotide sequence ID" value="XM_028287624.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497369.1">
        <property type="nucleotide sequence ID" value="XM_050641412.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497900.1">
        <property type="nucleotide sequence ID" value="XM_050641943.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498750.1">
        <property type="nucleotide sequence ID" value="XM_050642793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499042.1">
        <property type="nucleotide sequence ID" value="XM_050643085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499868.1">
        <property type="nucleotide sequence ID" value="XM_050643911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500011.1">
        <property type="nucleotide sequence ID" value="XM_050644054.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507036.1">
        <property type="nucleotide sequence ID" value="XM_050651079.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507443.1">
        <property type="nucleotide sequence ID" value="XM_050651486.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507512.1">
        <property type="nucleotide sequence ID" value="XM_050651555.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508646.1">
        <property type="nucleotide sequence ID" value="XM_050652689.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508725.1">
        <property type="nucleotide sequence ID" value="XM_050652768.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510297.1">
        <property type="nucleotide sequence ID" value="XM_050654340.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512247.1">
        <property type="nucleotide sequence ID" value="XM_050656290.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512338.1">
        <property type="nucleotide sequence ID" value="XM_050656381.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513580.1">
        <property type="nucleotide sequence ID" value="XM_050657623.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514207.1">
        <property type="nucleotide sequence ID" value="XM_050658250.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515301.1">
        <property type="nucleotide sequence ID" value="XM_050659344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518833.1">
        <property type="nucleotide sequence ID" value="XM_050662876.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280292.2">
        <property type="protein sequence ID" value="XP_028136093.2"/>
        <property type="gene ID" value="LOC114330871"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287624.2">
        <property type="protein sequence ID" value="XP_028143425.2"/>
        <property type="gene ID" value="LOC114337218"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641412.1">
        <property type="protein sequence ID" value="XP_050497369.1"/>
        <property type="gene ID" value="LOC126878602"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641943.1">
        <property type="protein sequence ID" value="XP_050497900.1"/>
        <property type="gene ID" value="LOC126879053"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642793.1">
        <property type="protein sequence ID" value="XP_050498750.1"/>
        <property type="gene ID" value="LOC126879618"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643085.1">
        <property type="protein sequence ID" value="XP_050499042.1"/>
        <property type="gene ID" value="LOC126879816"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643911.1">
        <property type="protein sequence ID" value="XP_050499868.1"/>
        <property type="gene ID" value="LOC126880157"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644054.1">
        <property type="protein sequence ID" value="XP_050500011.1"/>
        <property type="gene ID" value="LOC126880287"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651079.1">
        <property type="protein sequence ID" value="XP_050507036.1"/>
        <property type="gene ID" value="LOC126884821"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651486.1">
        <property type="protein sequence ID" value="XP_050507443.1"/>
        <property type="gene ID" value="LOC126885056"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651555.1">
        <property type="protein sequence ID" value="XP_050507512.1"/>
        <property type="gene ID" value="LOC126885122"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652689.1">
        <property type="protein sequence ID" value="XP_050508646.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652768.1">
        <property type="protein sequence ID" value="XP_050508725.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050654340.1">
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        <property type="protein sequence ID" value="XP_050512247.1"/>
        <property type="gene ID" value="LOC126888227"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656381.1">
        <property type="protein sequence ID" value="XP_050512338.1"/>
        <property type="gene ID" value="LOC126888273"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657623.1">
        <property type="protein sequence ID" value="XP_050513580.1"/>
        <property type="gene ID" value="LOC126889370"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658250.1">
        <property type="protein sequence ID" value="XP_050514207.1"/>
        <property type="gene ID" value="LOC126889717"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659344.1">
        <property type="protein sequence ID" value="XP_050515301.1"/>
        <property type="gene ID" value="LOC126890427"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662876.1">
        <property type="protein sequence ID" value="XP_050518833.1"/>
        <property type="gene ID" value="LOC126892938"/>
    </dbReference>
    <dbReference type="GeneID" id="114330871"/>
    <dbReference type="GeneID" id="114337218"/>
    <dbReference type="GeneID" id="126878602"/>
    <dbReference type="GeneID" id="126879053"/>
    <dbReference type="GeneID" id="126879618"/>
    <dbReference type="GeneID" id="126879816"/>
    <dbReference type="GeneID" id="126880157"/>
    <dbReference type="GeneID" id="126880287"/>
    <dbReference type="GeneID" id="126884821"/>
    <dbReference type="GeneID" id="126885056"/>
    <dbReference type="GeneID" id="126885122"/>
    <dbReference type="GeneID" id="126885894"/>
    <dbReference type="GeneID" id="126885941"/>
    <dbReference type="GeneID" id="126887034"/>
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    <dbReference type="GeneID" id="126890427"/>
    <dbReference type="GeneID" id="126892938"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="3">
        <location>
            <begin position="616"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="831" mass="96327" checksum="C26D515C885BFA5E" modified="2025-10-08" version="1">MKRGALMVKMAMSMNPTQHENSGESSNDTAGSPISIATVESPSTLYTNQQYYGDLGELRCLHSPVHQEQQYCQLETPIEQQFSQHYNQYYDLPIPTSISLLVPEAEQYRQSPNNCLGYCSPLDNVIDLQTSIEQPRLQQRDEAKDSHNPTPSVVNFATRVLQEQVLQHQDDITRPSTSTGKLLPTISHQTDENSDPYATDGSSDVDFNPNDFDLDQQDALVSEEKIPDITKSRKRKRNPDNWRRNRIKKLRNSGKAYVNWKSKQVSERIMKPPCPTTCRLKCQTKFQEKHRVQIFQDFWKLGDINYQREFVLRNLTVKPTKHPRKKKDAVELPEGDTCESRRKLSYFYTFPQENCPVNTIKVCQTFFLNTLGISHQIVKTVVKKTHHSNSISPQADLRGKVQCNSRLPKHFKDSVRHHIKSFALIESHYCRKNSTKKYLPPDLNISKMYRLYKTYCSDNNINTIASYAIYREVFNNEFNLGFFIPKKDQCDFCNKLSNSSPSEKEELRSAMEAHLKNKDLSRANKELDKERAKTDNSFCMAIYDLQKTLLCPKAEVSLLYYRRKLACYNLTVYDAANKQGYCYMWPESLACRGACEIGSCILSFIDEMVRNGIKEFSFYSDNCTGQNRNRFIYCLYMYCAAKYGVKITHSFLEKGHTQNECDSVHGVIERAAKKIPIFSPQQWYTLARTACKVRPYKIKEMAQADFYDLKDLLAKTTKNWDKTELGCKVIFNNLKVIMVDPKCPNQLNVKYSFEEDFIKINTLELKRSHQKLDSLETYQLRMLRSSPVPIPAAKYKDLLFLCENKVIPTEYHNFFTNLQASNIPEQETDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBQ4</accession>
    <name>A0ABM5KBQ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507618.1">
        <property type="nucleotide sequence ID" value="XM_050651661.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651661.1">
        <property type="protein sequence ID" value="XP_050507618.1"/>
        <property type="gene ID" value="LOC126885207"/>
    </dbReference>
    <dbReference type="GeneID" id="126885207"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="539" mass="63164" checksum="388AF5FCF1511898" modified="2025-10-08" version="1">MTYSIFTTVMYVIYSMFIINITIMKSHNLMFSQFSYVKNFDLGKFNNMEVKQEASEMISCKVETDNETFDGPLDAFKVEIKEEPKTEPAYDTFGYLDCNEFPLKTEVEQEQDECKFTPSETKQTANESCSQEQNKMKGMETITAHSSHTHTGRHAEGKPLNKNMQVETLRRSYKCEICFKQFKERGQLKRHLMIHTGEKPHKCEICFKKFSQTYKLKIHLRVHTGAKPYKCEVCFKQFSEAGSLKKHLKVHTGETLHTYKCEICLKKFNQTCTLKRHLRVHTGEKPYNCEICLKEFADSSSLKRHLRVHTGEKLTKCEICFKQFSHIGLLKPHLRVHTGEQPYKCEICFKQFSQTCHLKRHLRVHTGEKPYKCKICLKELTDSSSLKKHLRVHTGEKPYKCEICLKGLTDSSSLKKHLRVHTGEKPYKCEICLKGLTDSSSLKKHLIVHTGEKLTKCEICFKQFSQISNLKTHLRMHTGEQPYKCEICFKQFSQTWYLKRHLRVHTGEKPYKCEICFKQFKEGGHLKRHLRVHTRETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD67</accession>
    <name>A0ABM5KD67_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508138.1">
        <property type="nucleotide sequence ID" value="XM_050652181.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652181.1">
        <property type="protein sequence ID" value="XP_050508138.1"/>
        <property type="gene ID" value="LOC126885586"/>
    </dbReference>
    <dbReference type="GeneID" id="126885586"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25417" checksum="6E872F878329C27E" modified="2025-10-08" version="1">MKKHVLMHTAGPVVCSTCGVTCKNFESLRGHIFHYHKHTAHQYVCEECGKSFRMKYYFLLHKRKDHMGLRNFKCNTCGKAFFVNKALLNHVRTTHEKLRRHVCEHCGTGFSTKHVLKTHKRQHTDEKPFVCEHCSEGFRQSVSLRTHLKSKHGIEVAQEFFCGTCEKGFATNWALSVHQRSHETKKCEICSENFAGDEYLTKHLREVHQVEVEMQQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFH4</accession>
    <name>A0ABM5KFH4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508944.1">
        <property type="nucleotide sequence ID" value="XM_050652987.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652987.1">
        <property type="protein sequence ID" value="XP_050508944.1"/>
        <property type="gene ID" value="LOC126886140"/>
    </dbReference>
    <dbReference type="GeneID" id="126886140"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="420" mass="46140" checksum="F1883B7EEDD8DEA8" modified="2025-10-08" version="1">MTGTFTLSNIQKTIVDSIQKEDSSFTENGYYSLALNNAFYALFNWITPSVIHLIGSKYSMCLGVIFNIMFILQFLIPKVWLLYTISALIGLGFSLLWVGEGNYITLNSTEDTISRNLGIFSFLSNFSMIFGNVLVMFAFSGKEVINEATRTYVILSLTGVCSAGLIIFCLLSQPVGKKDTNEEDVKVEGPVEAFVSATKLFITRKMLLLSFSFLYSGLELGFFSGVYSSCVGFTKKFDDRKQLVGISGILIGVGGVFGGGVLSLFGQKLLKLGRSYLAIVACSIHTLCFALIFINLPNSSTFSDTDEEAVIESSVFIAMFCAFLLGLGDSVFINVIYSLLGTVYSENSACAFAIFQFFQAIGIVINFVTAPVLGLYYQLAILFVLGLTSTTCYIHVNLSYTKANFEINTSKKMSNFKEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG38</accession>
    <name>A0ABM5KG38_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050509157.1">
        <property type="nucleotide sequence ID" value="XM_050653200.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653200.1">
        <property type="protein sequence ID" value="XP_050509157.1"/>
        <property type="gene ID" value="LOC126886324"/>
    </dbReference>
    <dbReference type="GeneID" id="126886324"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046294266" description="acid phosphatase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="369" mass="42878" checksum="01129E54F05979A6" modified="2025-10-08" version="1">MREIVVLLLLVLFQLCLGKPVENNGDELVGVAVCYRHGDRAPVSSFPNDPYIDAKYWPDGIGELVNKGKVHQFQLGQWLRRRYKNFLSTRYYPTELYVRSTDVDRTLNSAASNLAGLYYPDGSPYPVEWPQELPWNPVPIHTVEYKKDAVLAMKKECKNFEKLYQETLDSEYFKNVMKNHTELKEFVESKTGWNVTLDLFRNLWTVLYIYNETNSSYVPDWANEIDQEELAQLAGLSFSTETFTTKLQRFKVGPFFDYLNNYFDGILNGTNPKFLMLSAHDGTIASILNTFGDYNYKPPQFCSTIIWELYRTSAGEPYLNIYFKDGFKTESVVELKIGNCISACRLDFYKKVFRNITVDEDSWKHECKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG54</accession>
    <name>A0ABM5KG54_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509170.1">
        <property type="nucleotide sequence ID" value="XM_050653213.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653213.1">
        <property type="protein sequence ID" value="XP_050509170.1"/>
        <property type="gene ID" value="LOC126886340"/>
    </dbReference>
    <dbReference type="GeneID" id="126886340"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="404" mass="46925" checksum="9EC1DE6E192F1228" modified="2025-10-08" version="1">MDILSVQNEPFSDISIECFQYHTYLPYNSAALLYNDEIKIPIQDLEALTLPSNSYIYIEGQILTDKDAVPTKLKFINNAIAYLFREIRYEMNGVTLDSVRNLGLVSTLKNYLSLNDNTSKLLINAGWCPQEKDKILIDTKGNFNVFIPLKLWLGIFEDFNKVVLGSRQELILIREKDDLDAVIASDETENPKIKLSKISWHVPHITPSIPQQLILNKIINSNIELPIKFRSWELIEYPVLPNSTRHTWPVKTTTKLESPRHVIIAFQNNRKGNLLKDMSQFDHCNLRNIRVFLNSNRFPYNDLELDFESNRFATLYEMFANFQESYYHLTSNQPLLTPQEFKTMAPIIYIDASRQPEIIQSGSVTMRIEFETTQPIGTNISAYCLILHEKEFYYNPLTKIVRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGL9</accession>
    <name>A0ABM5KGL9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509339.1">
        <property type="nucleotide sequence ID" value="XM_050653382.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653382.1">
        <property type="protein sequence ID" value="XP_050509339.1"/>
        <property type="gene ID" value="LOC114338435"/>
    </dbReference>
    <dbReference type="GeneID" id="114338435"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045822752" evidence="3">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="288" mass="32550" checksum="291FFADEF3B6AED6" modified="2025-10-08" version="1">MKILIFLVIIASSISRSFQTCARTTAVTTCSQVRLSKTNPLLIDDYKNILSISLDEHTDTIYSNVFKRLAELKRLYLSNNKIKSLESGSFDGLSKLEELSLYNNLLTTVVSGTFRDLHNLKILNLGSNKITSIPNNAFLGLDNLEEINLSFNQLAEIPVQINTIKSLRSLHMNSNKLKSLKANSFRNLNKLETLNLHDNIIDSLEAKSFAGLRNLKQLSLKSNYLKQFNTQDVLEDLGSLQILSLAINDLKCADLRNIDRELKRKRVDFEAGINKQNPNTYRGIKCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHT3</accession>
    <name>A0ABM5KHT3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509759.1">
        <property type="nucleotide sequence ID" value="XM_050653802.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653802.1">
        <property type="protein sequence ID" value="XP_050509759.1"/>
        <property type="gene ID" value="LOC126886774"/>
    </dbReference>
    <dbReference type="GeneID" id="126886774"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433283" evidence="3">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="265" mass="29067" checksum="48AE193D72031129" modified="2025-10-08" version="1">MFAFIFLCLLLQTLTFPPTLGRDADQNEYPLIVAVESCNFPVCYPQCAGVVLSKSWILTLGSCAYVATNFDHYRINAGVVNVTSEGAQLRDIEKALLHPEFNYFQPFSPNNIGLLKLKTPLNLGDSVQPGVLPTQGSDVPLGKVTQLGWYVNKGERDIPVSVENLETADTAMIDYDVCMAVVEPSMDYKFPDFAQTLFCTGDFTGREDLCFVSNGSPTIQEGVVVGIYYSPTLACGVMGSAMLTLKTGPYVSWIQENIDEDIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIA9</accession>
    <name>A0ABM5KIA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509930.1">
        <property type="nucleotide sequence ID" value="XM_050653973.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653973.1">
        <property type="protein sequence ID" value="XP_050509930.1"/>
        <property type="gene ID" value="LOC126886861"/>
    </dbReference>
    <dbReference type="GeneID" id="126886861"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="529" mass="62936" checksum="1865C5E9BE41B0D1" modified="2025-10-08" version="1">MEVKQEVCEETCKIEIDSDMNDALLDGIKIEFKQEPKIETTHDDTFEVADADLKKIPIKTEIGQDEHELMSLEERQTNKIEFPQETHTLEIRKTIHVHSSHTGEKPYKCEICFGQFSHASSLKLHMRLHTGEKPYKCQICFKSFTQKINLDQHIKVHTGEKPYKCQICFKSFTQKTNLKHHIKVHTGEKPQKCEICLKQFARESYLERHLRVHTGEKPYKCEICNKSFGVAFYLKQHMRSHTGEKPYKCQICFKSFTQKIYLVQHIKVHTGEKPYKCQICFKSFTHKNRLNDHIKVHTGENPYKCEICDKQFVRKDVLNEHVRVHTGEKPHKCEICFGQFTRVSSLKQHIMRLHTGEKPYKCQICFKSFAQKIHLNQHIKVHTSEKPYKCEICDKQFRVPYHLKQHMITHAREKPYMCEICEKQFGVAFYLKQHMRSHTVEKPYKCQICFKSFIQKFHLNQHIKIHTGEKPYKCKICDKQFRVPYHLKQHIITHTGEKPYKCEICFKQFTKKYSLNRHTKVHTVEKPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJD9</accession>
    <name>A0ABM5KJD9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fanconi anemia group M protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510218.1">
        <property type="nucleotide sequence ID" value="XM_050654261.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654261.1">
        <property type="protein sequence ID" value="XP_050510218.1"/>
        <property type="gene ID" value="LOC114349470"/>
    </dbReference>
    <dbReference type="GeneID" id="114349470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="45"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="386"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1316"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1594"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1322"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1595"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1620" mass="183816" checksum="77B261E84105A19B" modified="2025-10-08" version="1">MNKNLNNTLSTNLSKDPETEGFDLQAGETWIYPTNYPVREYQYNIVQQALLKNTLVSLPTGLGKTFIAAVVMFNYFRWYPQGKVIFMAPTKPLVKQQIDACYDIMAIPKECTVEITGAKISTSREDMWKEKRVFFITPQILQNDLVKFEDLGSKIKCLVFDEAHRARGNHAYCEVIRKLSSSNKYFRVLALSATPGGTINDVLEVVQNLLISHLEFRTEESPDVSPYVFQRNLTTVVVPLGTKLQEVKDSYMKVLEYYTRSLIRYKVIQGNCANLTKGKIFILMKNYQQNARGTSPNYAEIMKSLNICITLYHASELLIRHGLRSFLTFFEEHIDKPLLRNNTDIREIMATIREHMGPLPQIQQLPDGEYQEVPPNIKFGHPKFYKLKEILLEHFSETEDSSRVIVFFEYRESVMEAFVLLIQSKPVLKPRIFIGQANGVSQKTQISVVKAFREGRCNVLLSTSIGEEGLDVGEVDLIVCFDISNKSPIRMVQRMGRTGRKKDGKIVVLVTEGKEQQTLKDCLIHKNNVAFHVLGSKVLAQGLHSECPRLIPEDITPKCEKIFITVEDPGPKKSGNLKDMLKSLSRKSSELSFSPGLEIVEIEEKIPEPELLSVKENPLDGSIVPNIFNKKIEKQRSFQEIHTVEHSSNCGLLVSLLQMAESRRFNIPMSQIATTTQKNKNMKQTDIRNMFFKSQSASDFIVPSTQVIAESIQTTNTEDKNFGEPELFRELSDFLSIQQDNSRKCTLCPSQLNCGDNKYKTPSKSSFAWIELDPSVFTNITAEDLKAFEKSLHPVADASFQFDESIHFKIPETPVTQTTQKETKVMELEDLIDTSILADFSDTAATTATNTTATFMPPKSLNNLLNKYSTSLIDENLQFPPPTDTQHSEYNNKSTLEVIRTKKSFSEEETKDILDFFKLETLEDVFETNIPDSQATITYSPDIFDITNTANTNVIIEDDISEDSNSPIICSYFNKKKNVTIRNSQIEATYSQSLSSTPLTRKTEKNIDKLSQSSNKLCGNTGDPKKTPPEDLNDFFDFSFFASQSSKKNETVVKAKEIINLTDSCNTIDFCEDSSNSRKNSESDANNCKLNVNISELGSFFDEELLMSPTFRQVDHRKVNVKESLEKTKRKIESQVMSRNVASVNEERVLSQKVVQMHRENHNLNTDKSQKVSESEIEQKIDSEIPESMDFLQFMENDDFQLPSITKNKNFDIPDPLSDFKLPGITKIKNLDIADPPSCQFNDKHPKTSVLNTQTDNTVQKSLSTIEKLEPSQASITQLISLVNKPTQTNSLSQKENIDLSDVENDSFIFSFNAKKPKRTKNTSSSSEKSLNSSIKANIKEHSNNSSINTTLGSKSADSSKGILDNSAIVSPKPVALSDRTKKMQSSSNTSLNTSNSDDEFETKPPSSGWIRTRPLVKKRPILNNSDDEFEPIEHSPVFAKPKPVKRIRIEKEEGSRNQARNVTTRVKSRKLVNEFIENEAELSICDETNVSDDEADEFLSQEQYDASFVADETQHVDTQMHAVYLKSVRSPRNIPGRFKIPTRFKNNMNVFSQVDNEEDEVDSDDSFVVMDETIEARQELSQLEILEKQLEMQKRRKKMPHGIKKPTKRRRIIVSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLW1</accession>
    <name>A0ABM5KLW1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511185.1">
        <property type="nucleotide sequence ID" value="XM_050655228.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655228.1">
        <property type="protein sequence ID" value="XP_050511185.1"/>
        <property type="gene ID" value="LOC126887624"/>
    </dbReference>
    <dbReference type="GeneID" id="126887624"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="256" mass="29842" checksum="925B4185766D5E2F" modified="2025-10-08" version="1">MYADDVVLVGNSERGLEQKLEQWRQALEEKGLKLSRTKTEYLECSFKDGATSNKMVSLDGEMIVKSYSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVAEMRMLRWMSGVTKKDKIRNEYIRGSLGVAPIDAKMREHRLRWFGHIQRRDVNHPIRRVAEVQIPGRSRRGRPKKTWGETIRQDMWVKGINIDMTQDRIVWRNAIREADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ81</accession>
    <name>A0ABM5KQ81_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512346.1">
        <property type="nucleotide sequence ID" value="XM_050656389.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656389.1">
        <property type="protein sequence ID" value="XP_050512346.1"/>
        <property type="gene ID" value="LOC126888278"/>
    </dbReference>
    <dbReference type="GeneID" id="126888278"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046568606" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="25060" checksum="6C8E6A0B145AF854" modified="2025-10-08" version="1">MFRYNTLIALAFIIASINAFVVPDFDPGYALDPNDDAQLRNIKIYGSGQGGLKLDPYRFNLFGINGVLGGQLQGEGSGFANIDTPVALRNIKIQGHGEGGVKLDPTRIHLFGHSGVLGGQLHGEGSGVVDIDTPVAVRNIKIQGHGQGGVKLDPTRIHLFGHDGVLGGQLQGEGSGFADIDTPGALRNIKLYGQGQAGVQVDPFRFGLFGLNGVLGGQAQGQGSGFIDINTPIAYGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQI3</accession>
    <name>A0ABM5KQI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512444.1">
        <property type="nucleotide sequence ID" value="XM_050656487.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656487.1">
        <property type="protein sequence ID" value="XP_050512444.1"/>
        <property type="gene ID" value="LOC114334933"/>
    </dbReference>
    <dbReference type="GeneID" id="114334933"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="425" mass="49435" checksum="AE8F5174DF5F350F" modified="2025-10-08" version="1">MEKLDTPKRFGYPENFFHTNEIITKISGMWIPTREHRFLFRVFYIIYLFFLYGSGLFFLICECLIFNETITTINKLVSHIGMLFTHLVGILKFCILVFGRQKLKRIMDTLQDVQYYYEPTKDFSPGQFLSDEKITSSRFSILVFVMYSFVGVSAHISSELIINSEIKGQTFEGTNRTCQDFMPYYFYIPFSTFFKWQCEFAFIFMDVGLCIFAWLIACHDGVFVSLLNCLKSQLLIVCHVFRTLRERSLKNAMLAKDYKPMYDTECPALEKEMYQQLSYSTEHLKILLRVRDEIEAIFTFVTLSQTLASLLIFASCLYIASSVPMTSPEFFAQMEYFSCVLVQLSLICWFGNEITSASALIKLALYECDWLSSSTRFKNSMILTMIRMQRPVYVSIGKFSPLTLTTLVAVCRGSFSYFALFKSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQW2</accession>
    <name>A0ABM5KQW2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512574.1">
        <property type="nucleotide sequence ID" value="XM_050656617.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656617.1">
        <property type="protein sequence ID" value="XP_050512574.1"/>
        <property type="gene ID" value="LOC114325243"/>
    </dbReference>
    <dbReference type="GeneID" id="114325243"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="161" mass="18305" checksum="745ECC5844698F6F" modified="2025-10-08" version="1">MGKLSLQIKATLEGLEELYTNHPDYNFLLKLKCTSCGEESNKWHDVSEAVTFPGKTGKSENNYIAKCKLCSRENCLDIVPGSNGKYTNEDSGKFKTIVSFECRGIEPFEFAPSEGWIAKVEESNKIFDNINLTEKEWVEYDEKSQQSVGVYEFESKFVPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS05</accession>
    <name>A0ABM5KS05_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512971.1">
        <property type="nucleotide sequence ID" value="XM_050657014.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657014.1">
        <property type="protein sequence ID" value="XP_050512971.1"/>
        <property type="gene ID" value="LOC126888653"/>
    </dbReference>
    <dbReference type="GeneID" id="126888653"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047434055" evidence="2">
        <location>
            <begin position="19"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="723" mass="75851" checksum="D6F39D5785EC31C5" modified="2025-10-08" version="1">MLAITFILLGTLIACCKSEVVFNAIALDDILSEDYMPTTLLMLENPKIIRKYENSTADSKIDKTILGLDGSLGKAMETMDFHRSMMNQYMCRSFVAEQIVANMSTSRVKRRMGHVTSGVGESSSPQTDISKNLIYDEGSSGYQDWLSKSATLEDIYRHYDNPQDRIDVVEDVDDGNPEDFEEGYNVEDINKQETKAALNHRHEETYYSAAGYPGPSYSNSYGPPNYSPSSYGQQSYNPPNYNQPTYSQPSYNQPTYGGSPDYHQNTGGGGGYQQHQPESHGSYEPHFPEPEYHNSPPAPKYHVYNYYSKDKDLSDLFEIALTGLAFLAFKMFIVHVIMCIASTTTTNTTTTTVAMAMSMSPTATATGNGMADIPGTGGGTSTGGGMTSTGGGMPSTGADMPGTGGGMTSTGGGMTSTGGGMTGDGGDTPGTGGGMTSDGGDMPGTGSGMTSDGGDMPGTGGGMTSDGSDMPGTGDGMTGGDMPGTGDGMTDDGMTDMGGGMTGGGTGTGDGGDGSTDTGSTGSGTTGTGDGMDAGMGGDSTGTGGTDGGTGMGTTGSDSTGTGGSSAMGTGMDETAADGTATGDGSEALQFRYKRNPMPQFPNPKNEIINELSRKILLTIESSLVAHKDDGVCLRKILCENNKWSRDLEGRHKLFIPLWSLGMSWLSGKIVHNVAPATSMLDTLKASILGLGKANCEIIYQKCDLRNHVMERKRRKRRKREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS85</accession>
    <name>A0ABM5KS85_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513046.1">
        <property type="nucleotide sequence ID" value="XM_050657089.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657089.1">
        <property type="protein sequence ID" value="XP_050513046.1"/>
        <property type="gene ID" value="LOC126888709"/>
    </dbReference>
    <dbReference type="GeneID" id="126888709"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25437" checksum="F65E584245426276" modified="2025-10-08" version="1">MCLQNTATLDAHGFICEDTPTDECNELKDHVINKQQVTQCTTAVKKVKAVERRFVREICTKQFSRRSHLKVHMMTHTGEKPFACEICSKRFSSNTHLKIYMPTHSQEKQFECEICPKQYSTSSYLRVHMKMHTGENQFECEICTKQFLRSSALKLHMRVHTGEKPFACEICFKQFSNSSYLKEHMNIHSQGKPFGCEICSKLFSWTFSLKRHMKIHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSU4</accession>
    <name>A0ABM5KSU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513251.1">
        <property type="nucleotide sequence ID" value="XM_050657294.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657294.1">
        <property type="protein sequence ID" value="XP_050513251.1"/>
        <property type="gene ID" value="LOC114332680"/>
    </dbReference>
    <dbReference type="GeneID" id="114332680"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01236">
        <property type="entry name" value="PH_RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="501"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1574" mass="180296" checksum="D4A2409128538993" modified="2025-10-08" version="1">MSQCKKFAPNIFHKTKCSNCFKQKEEHSAEALECNRASRSIARSGYLFVAPDWDFSVPLNRTKRWQRRWFVLYDDGELNYSVDEHPDTVPQGSVDMCKVLEVTGAEQVTGHPHSLALTSPDRVTFVKAASREDARWWVELLAVFPRRHKRNATFPGGRASPSLPQLGRSASPQPPRPRHLSVTGPSPRTNFETPPLKEERESPPKEQDTKGQIPPPSSWTPPARTNSLPIEAPITTAGYLRPDYIVSSGSPPTRDKLRCEDKARARKDWRNERLRDIATALTDQHRPLQSESSSLALPAEGLLHLKKGWLWHRLSDSEWVRRWIVLCCPTLQIYQDQDEQSTPELTIELSAVTNCVEVTTSSKYGFEIQWSGPALVLSAVTHGIRSNWLQALRKAANLSTEGVVIVESPISPTTPRSLLASSDEEYRTASEGGRRGSEDWSELPPSPPLNRLSINRVKDRARLRPRLPRCQSRYSTVDSTSTDELDCAKEPDNVQIHNAFNSKQNDEMVELEKKLQKAEEEVQLLEEEIARLKKLQSDAAIREKKAKEMLSNMEKTEIELNQRNSQIEINFLKEQRVLQRRLSETEETAKMHEEKCNLLSRDLQNKQRMIVNLRDELITSNERLSEEKEENTKLFLRIQELEGRFKSKNFKTDSISELTNINLDLDIDELNQNELKEYCLDLKSRFERAILEIRAMKRALRESDENCDRLEVSNNRLMDSVEVQQQEHEAEVKLLVQRLDHLTTKLVTTEKQLKTKSKTEAKEKRRSLSLKGRESFSINKEVEDKVTELEAKILALERGKTRRRYKRDRSNDRSSPIDDKSLRRLRRKSLDSATSSEPMKLLMRLSSLESKVTNVDASNESLNTPQGSISDLTKPKDAVSESKNLDIDFLLSTAKLKVNECLNSIYMLKSNKKRSSSPSLDKLISIENCLNELLDILNRRDCSISTGEIEVINTSAGAVVKQLQNLLLSKLTNLAEKKRLLQENNNWNSIARLQILAEKVAYENILISRIQEALLSPVTGEAICERLINKEIKETAYLIIALENRINGSSDKQPTCKTSAEYLSKILAKCLVSAAHGFKSFKNFIKTKGSSINLLCDEKRNLDALLSAYKTDKLPQLAETLAVETICLSSDQSCRIESVTDEFSKTARDVVTAELIRSEIHHVLLRAAQVYQSNLDADHAFFFSFFASERAALELWSDSVGDCLFEEVNKSITELTEMYQNSLNKLLKQNWRCRVESVRNTRTSTTMLHDYAEIIAHKSLIDARIAVLSGQYIPEDYNDSRNTLGCWIENEKYWSLIEDQSLVQINQSLEVEFNCMVDKFSQDCYAMLSQPELEEILVYLNEMSSRVTDLQKCLDVPVNREDVALRTWSDVCQMCVNLRNSLEDIRKAMDENSSFKKYNLLEEERPVYLRTEYLTQVENLRTAYRRALATCKDRHKEEDMEKLQQICERVLSAMEQWHLRTIHELREAHAQEVDILKEEKEQALAEETQATLAALDAMRKAHVAEVQREVAKFKQDFVRQQRDSMFDLSEQLSVKSLEAAALEEQLGTATRQLAHAQQHILKLERNPQISSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVG5</accession>
    <name>A0ABM5KVG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 15-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514178.1">
        <property type="nucleotide sequence ID" value="XM_050658221.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658221.1">
        <property type="protein sequence ID" value="XP_050514178.1"/>
        <property type="gene ID" value="LOC126889695"/>
    </dbReference>
    <dbReference type="GeneID" id="126889695"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31391" checksum="A707E30A0E29BE3E" modified="2025-10-08" version="1">MFEGASIHTLRLECNQISNIHKNTFKKLNNLTYLMLHDNNIHNLGNIFCHIETKELYNLSLVNNKIAALEPGCFEGSKIIGIYLENNRLTEIKKGVFNGLNFGAIDLANNQITSIEEGSFSNLPLKYLYLTGNKLEKVSKTLLSGLDYVMEDIYLGENQITEIKPGSFLGLTIQGLHLNNNKLTCIKKGLFTGEDIEELDLSNNEISEIEVGAFNELKGLVSINLSNNKLTKIKKGMFNISLDKINFENNEIDFIENEAMENIRFESLQLQNNPVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW25</accession>
    <name>A0ABM5KW25_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514397.1">
        <property type="nucleotide sequence ID" value="XM_050658440.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658440.1">
        <property type="protein sequence ID" value="XP_050514397.1"/>
        <property type="gene ID" value="LOC114326938"/>
    </dbReference>
    <dbReference type="GeneID" id="114326938"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="651" mass="77563" checksum="0A964E21921C3168" modified="2025-10-08" version="1">MAQSDTAHDRNLLSATVKAEILNNDDSTLDNNFSGKAIDFQFSIQPKVEQSEIKDEVEELEFVGEVIEFSENELSGLEESQEPNYGTTKESYWCEQCNAESCYKKHDLHADFIRITTKPLNQSNPYECATCSIKLLNPTIALFHLSLHDKDSFRCYKCNCILLEFSDFLEHIEKLHSKDKDYYRCVECNFVTFWHLQYADHNNKFHKPKLFHKCKLCDEFWPSRNHSLHEKMLHIKSKYGRNPYVCKKCEIELVDPDEIYDHLKIHGDIGIFCSFCAFTSENLEDLENHKKDNHAEEVEKQRIIRESCKEYMENDNDIKCDLCNRYWPDKIHSNHERMILVEKQVTEDTPYKCTACNKKTCNLREVYKHVNRYCRYTMKCPFCSKVFRRRQGLDNHVIREHPGKKYVMDNRILKCKLCEYSTVVRKNFHSHVFSHKSKEDRPQYNCNECNFTTYNSSYLKKHRLIKHPVESDTLHTCDKCTYSTYLTSRMTKHLKTHVDNEIFKCDICNGLFGRERSLQRHKVRHFQEKKEKKQYVCEICAKVYYFKPSLLQHLYCAHQQGEAKVYICYTCKYKSYNRIQFISHTKLHIKQEFLYCANCEYKTFRKMNLIQHMVKHADSSKLQLHKCKVCSFETKRAHTLRNHVKYTHGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXI7</accession>
    <name>A0ABM5KXI7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514906.1">
        <property type="nucleotide sequence ID" value="XM_050658949.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658949.1">
        <property type="protein sequence ID" value="XP_050514906.1"/>
        <property type="gene ID" value="LOC126890101"/>
    </dbReference>
    <dbReference type="GeneID" id="126890101"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF77">
        <property type="entry name" value="ASPARTIC PUTATIVE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41294" checksum="851C03AA98FD5F72" modified="2025-10-08" version="1">MSNSNDLLSTIPEPLQLVKTKQFDKSVSKVLGLQWEEKCDNFSFGLEIPSSTRCTKRNMLSLVARMFDPLGFLSPITLLLKIWIKKLWTLKVDWDSTVPKEIEIAWEKFQNEFHVLYKIQIPRHIAVTPNSSLSFLGFSDASAAGYAAIVYSRVVNCTGQVKVTLLYSQSKVSPMSKITLPRLELCGALLLSKLLSHAIETYSPRHNIDKIFALSDSMIVLNWIKSSEKNLKIFVQNRVVTIHKMVPSEYWFFVPGKENVVDCASRGLFPSSLVNHSTWFTGPNWLLLEPEYWPLQSVNGQEIMICDSAYSLQTFFADKKFIESELGRFETDDDSDKNYETEITTLGPFFHRLPLDKNICPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXK7</accession>
    <name>A0ABM5KXK7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514907.1">
        <property type="nucleotide sequence ID" value="XM_050658950.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658950.1">
        <property type="protein sequence ID" value="XP_050514907.1"/>
        <property type="gene ID" value="LOC126890102"/>
    </dbReference>
    <dbReference type="GeneID" id="126890102"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121536" checksum="5E5BA3691391B7E0" modified="2025-10-08" version="1">MADKLKKYTFQRRMAMNDLETLLRLSNSSLTEVHKQSLFRVRYSELDDVLESFNKNHQNIVTNLLNSEPTGAQLDSEDIIRSQFLNDYYQIKANFADLFENDDNSQKNEQNIAASNAVQPPSNVRLPQLELVKFSGEFTSAITFFDLFDALVHRRPNVDDTEKLTYLIQSLEGPPLRLAKSLPLARENYVRIYDKLKNRYLNKRLRAMAHWCKIEEAPATMFKNSDSYSNLIDTFSENLSALENLGYKISDFVLAYKILTKLDEETHQRFELLHGSSEMPTFIQLSDFLESQCISFDSSLLSPCSPKDSNRKNKSPSKHNANKNGSKVNNRYSFFSKPNATTCLLCSADHHLKDCSLFLNKSPYERYNACKRMRLCFKCLEKHDSRSCSVTSRCCHCNSSHHSLLHFKSSESATQGATSVAAVPTTASSDAQVNTGTLSSHAASLGSVTSKNSSVLLATAVVEIMDGCGLYQPVRALIDGGSMTSFVSQSCIRQLGIRHSSATLSVQGIGAIKSTVVGRVDLQIKPVDRVDPIFNCEAFVLPKICEDLPVVSLDVGHWSYIANLKLADPRFHLSGKVDLLLGADIFSQLLLEGKVQTPRGMPDALNTVFGYVLMGPCSSVPMTSATSLFCHVDQMVSLEESVKQFWSLETVPEVECSAPEDILCEKNFVENVCRDGSGRYTVALPFRELSPVFPGMFELAVNRFLSLEKRLLKNPSVYQEYCTFMKDYLDLHHMELVSSPDEELQEFRLLTYGVSSAPFLALRTLLQLSEDEGREFPLAAEVLRTSTYVDDIVCGGDTLEIALDLRNELISLLSRGQFELRKWSSNDMRLLEGLPESYIGKKPISFDDNSCSSPLKILGLVWNAQLDCFSFEVTALDKSCTKRSMLSELARVFDPVGFLAPMTLFTKHLIQRLWLSGIDWDDSPPDSICKVWNQYKEQLLSLAQLEIPRCMFVSRYICCEERLSPNSWFYVPSAQNPADLASRGVLPALMLEQSHWFAGPEFLYNTDPIPDASCCFSECAEMFDEERTNSKYITDRPEHDFEAIKSTSFLPENLIKVVDPVIERNAFFPPRTFATEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZR2</accession>
    <name>A0ABM5KZR2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515674.1">
        <property type="nucleotide sequence ID" value="XM_050659717.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659717.1">
        <property type="protein sequence ID" value="XP_050515674.1"/>
        <property type="gene ID" value="LOC114338436"/>
    </dbReference>
    <dbReference type="GeneID" id="114338436"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="120" mass="13613" checksum="58074B8D893DD471" modified="2025-10-08" version="1">MMNTGHSVIFTVENDTRQHINVTGGPLSYKYQFQEIHIHYGLHDQFGSEHSINGYAFPAEIQIFGFNSQLYSNFSEALHKAQGIVVISLLLQLGDLSNPELRILTDQMDKIRYGGKERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZS8</accession>
    <name>A0ABM5KZS8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515693.1">
        <property type="nucleotide sequence ID" value="XM_050659736.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659736.1">
        <property type="protein sequence ID" value="XP_050515693.1"/>
        <property type="gene ID" value="LOC126890641"/>
    </dbReference>
    <dbReference type="GeneID" id="126890641"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="473" mass="56923" checksum="3242681FC64882A4" modified="2025-10-08" version="1">METRLNKKQKETEERYSEEGIENVDEEISITETTIKETTTEMSTMDRILQMLQIQEENSRRQAEKIKKSIDENSKRQDLGFKQMEQRLEQHKEEVQMYVKQMKHEVEQKTKEISQNLEKHTKKLQNLEKHVEDRDEEIEDRFRKLDKKLLEVKTQHNTGERRQVIIHNGAENKVQFGGDIKKQHPVPFIRMLKNKKQGYEEFEEAKDMIRTHFRDGAALWFESKQNELQDWEEFERKFLRYYWGKEKQMVVNSELQNGKYDEKLGISEEKYALQVYASGQYLNYNYSEEQLVELIARHFDNTMEDYVTLQGYRDMDSLCQFLVVREARRKERRTGKQTENNGNNQTNRTNNYRQSRNENPYRYNGYRDNEGQRYTNNFNQNRYEQNRNGYHQNRFQNSGRNYNNQPYQPNAGRENCNRGNQYNNNNGQGREQNREINSLSFIREGENEQGHQEIDNVEVEINRAGSSFQEGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZT6</accession>
    <name>A0ABM5KZT6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SKICH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515701.1">
        <property type="nucleotide sequence ID" value="XM_050659744.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659744.1">
        <property type="protein sequence ID" value="XP_050515701.1"/>
        <property type="gene ID" value="LOC126890647"/>
    </dbReference>
    <dbReference type="GeneID" id="126890647"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051002">
        <property type="entry name" value="UBA_autophagy_assoc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31915">
        <property type="entry name" value="SKICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31915:SF6">
        <property type="entry name" value="SKICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKICH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="284" mass="33195" checksum="9E1C8C2968C18E34" modified="2025-10-08" version="1">MGEHSFESNFVSMKHSVQFLDIQDQYYCNADLLCTFKFNDYVPQEGDRVAIFKLGWSFVKDYILFEWAPVDTKSEDNIYTVTFNKHVLPKKNFDEIYQICYLSGENELHGASSPFQLSSEKPKPIEISTSVFTVEDSLYQSLSKHKVISTVHCDHEDEIKKLKEENQILKEALKVALAHNESPQSTSKNYDKDIADLKQITGELKSCLEMQRQEFDVLKTKITDSKEEYKKLYLEKYKIHKKYEHLKTKIEREAKPNNFRLEFDISDLDSMPPFPLSNSNDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2I6</accession>
    <name>A0ABM5L2I6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516648.1">
        <property type="nucleotide sequence ID" value="XM_050660691.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660691.1">
        <property type="protein sequence ID" value="XP_050516648.1"/>
        <property type="gene ID" value="LOC126891514"/>
    </dbReference>
    <dbReference type="GeneID" id="126891514"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="463" mass="53076" checksum="CB97BF29C2385124" modified="2025-10-08" version="1">MPKSQNELKLERLCSKRETIFRRAQLCYDAGSALEKDPENASKMRNFAVRYSTFEKTLSEYEEIVQDIVILKQEMEPDAGVAYHTHLDAFYDLYSNIEYLASLLINKPAVLSNNPNSTNNSTIKMPKFELVKFDGGFKLTKWMSNSNDLLSTIPEPLQLVKTKQFDKSVSKVLGLQWEEKCDNFSFGLEIPSSTRCTKRNMLSLVARMFDPLGFLSPITLLLKIWIKKLWTLKVDWDSTVPKEIEIAWEKFQNEFHVLYKIQIPRHIVVTPNSSLSFVGFSDASAAGYAAIVYSRVVNCTGQVKVTLLYSQSKVSPMSKITLPRLELCGALLLSKLLSHAIETYSPRHNIDKIFALSDSMIVLNWIKSSEKNLKIFVQNRVVTIHKMVPSEYWFFVPGKENVVDCASRGLFPSSLVNHSTWFTGPNWLLLEPEYWPIQSVNGQEIMICDSEYRSQTFFDNFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2S0</accession>
    <name>A0ABM5L2S0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516733.1">
        <property type="nucleotide sequence ID" value="XM_050660776.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660776.1">
        <property type="protein sequence ID" value="XP_050516733.1"/>
        <property type="gene ID" value="LOC126891597"/>
    </dbReference>
    <dbReference type="GeneID" id="126891597"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="419" mass="46294" checksum="EAB1FF34DA9D2809" modified="2025-10-08" version="1">MTSNNTMNTTQTSSHISYSSVVNTFKQPTKDEAIVLSSIEGTKVQEYIIAVGSIVGPRNVSFASRIANNRICIYLSSKNMVDSLLHYHKYVNIKETQVEIRRLITPAQRLIISNADPSVPTTLIEQELRKMGINTISKMTFLRETECPDNANTITSNATTSNTTNIDSTNSNPPTSNTTNPDQTNSNPTSSKVLPETSQNTQYITNLPYNQTEQKLSDKTLISTSNDHPASSQNILVQIPDVQVSNNQLESTIETDDMSRPTNNTNETNTLKIPTSSTSNKISNLTPLEITQPKIIPNVTKHLKRLISSSPEINENTTQTDSHIFTSPTGHVRGRSKEAGGGSNKPVACPLDSAKYTKISEKLAEKVKIHPQSTRDPPNTHMASVIWKALNRLRNGVSRSREYQENDTYDCGAVQNSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L325</accession>
    <name>A0ABM5L325_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516844.1">
        <property type="nucleotide sequence ID" value="XM_050660887.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660887.1">
        <property type="protein sequence ID" value="XP_050516844.1"/>
        <property type="gene ID" value="LOC126891658"/>
    </dbReference>
    <dbReference type="GeneID" id="126891658"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF1">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57927" checksum="2B3EF792BE49FEAD" modified="2025-10-08" version="1">MHPGQLEVLDKYSEDVICIDGTHGLNAHDFELTTLLILDDMREGFPCWFMIGNRSDEEIMTIFFMKIKENLGRVIKPMVFMSDMAQYYYNAWLQIMTPAKFRLFCSWHVDKAWRKNLNKIDGQEQKVIVYKQLRTLLQETDVTSFRDMIQNFQISLLSSGNTQEFGQYFQKCYLHNMESWAYCYRLHAGINTNMSIERMHQTIKYLYLNGRQVRRLDKTINILIKLIKDKLFERLITLNKGKISSKLRELRKRHKTSLNLDMDTIVISEMGWEIPSSSTNDIYLVQKNKPSCDRRLVCDLCQSCLHSYSCTCLDNSIRWNMCKHIHLVCQFMKGHQIQDTNADEEHIINTDEVKIKQATEQAKFMEFVSKSCNINQEKTSKQLEVEKQKLIEIQTQIIQNITTFEQLEAFKSITAPLVPTLRTLAEHSGNELNIVALSHGTQNIPHNKKVVAQKRLFSTKKKTTKSKKKLLSKPDAEETNLIANQLMLQVNNVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L424</accession>
    <name>A0ABM5L424_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L14</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517183.1">
        <property type="nucleotide sequence ID" value="XM_050661226.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661226.1">
        <property type="protein sequence ID" value="XP_050517183.1"/>
        <property type="gene ID" value="LOC126891887"/>
    </dbReference>
    <dbReference type="GeneID" id="126891887"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="8">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="169" mass="19390" checksum="C444DE8CE73EFB88" modified="2025-10-08" version="1">MPFQRFVETGRVAVVSEGPHKGKLVSIVDVIDQTRVLVDGPNSNVPRGQLRLNELHLTKFRIRYPFSAPTRVVRKAWTDAKIDEKWNESVWAKKVAAKEKRSQLTDLDRFKLRRARSRRNHIRTATFLSLRKAASRNGFLYGKKKMAKGGDKPKPSKKAKKEKPASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8W4</accession>
    <name>A0ABM5L8W4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Deformed epidermal autoregulatory factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518881.1">
        <property type="nucleotide sequence ID" value="XM_050662924.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662924.1">
        <property type="protein sequence ID" value="XP_050518881.1"/>
        <property type="gene ID" value="LOC126892974"/>
    </dbReference>
    <dbReference type="GeneID" id="126892974"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF1">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAND" evidence="9">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
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        <location>
            <begin position="362"/>
            <end position="398"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46329" checksum="AD06F60654C3248D" modified="2025-10-08" version="1">MENSNSEGVVLPDISEAEHLASEHDNDNGDSVVDSKKSLVSTVSVRHAGVPVTLPVGSLITSTFNVITQDQIPHFKPMICVDNSGYLATDGSTGELKTIVIQQEDVSGGSSVNTPVSSASVGSWNDAANAAVLPVRCKNTSAELHKCRFGSGGRGRCIKLGNSWYTPSEFEALCGRASSKDWKRSIRFGGRSLQTLIDEGIILPHATSCTCAACCDDETATGPVRLFTPYKRKRRKENDSIKRSNGEDSDHQCKEEAWQNLAEGLDSNDYQLIEPVGSIDPQIQIKRLEEIALQINRLALEFRRGMEDLKDTMNRQSEKYQREKEAAILAARVEAQVAALQPEGNSDTTLQPSMDNENHKKCANCNREALAECSLCRRTPYCSTFCQRKDWASHQVECVRGVAAATGEAQQSIMLIVESTDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8Z0</accession>
    <name>A0ABM5L8Z0_DIAVI</name>
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        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518908.1">
        <property type="nucleotide sequence ID" value="XM_050662951.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662951.1">
        <property type="protein sequence ID" value="XP_050518908.1"/>
        <property type="gene ID" value="LOC126893013"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
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    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31040" checksum="59CE001ADA6697A6" modified="2025-10-08" version="1">MAENQAVPNGSHVLANMATVSAPSEFNFSLPGSWNQWKKRLQRYMSVSGFIDKPEVEKIDMLMYLMGAEAEEIITQFNLTPAQQFNTRSQQPGESVDAYITELHSLAEHCSYGALKDELIRDSIVVGVLDVKVSERLQLQKNLTLGEAVLTVRQAELQNSQNKILRQERVQEVATVNAHRGNYWSQSQAEPNKYGQQNPQGKSNTNYKCTYCRVPSCNSRERCPAKDSRCRLCGKKGHWQARCRSGRNVRVVEGQNCAESEVGIENEIENLKVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAP8</accession>
    <name>A0ABM5LAP8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Latrophilin Cirl</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519507.1">
        <property type="nucleotide sequence ID" value="XM_050663550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519508.1">
        <property type="nucleotide sequence ID" value="XM_050663551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519509.1">
        <property type="nucleotide sequence ID" value="XM_050663552.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050519507.1"/>
        <property type="gene ID" value="LOC114335105"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663551.1">
        <property type="protein sequence ID" value="XP_050519508.1"/>
        <property type="gene ID" value="LOC114335105"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663552.1">
        <property type="protein sequence ID" value="XP_050519509.1"/>
        <property type="gene ID" value="LOC114335105"/>
    </dbReference>
    <dbReference type="GeneID" id="114335105"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15440">
        <property type="entry name" value="7tmB2_latrophilin-like_invertebrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22830">
        <property type="entry name" value="Gal_Rha_Lectin_dCirl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048072">
        <property type="entry name" value="7tmB2_latrophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008077">
        <property type="entry name" value="GPCR_2_brain_angio_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF347">
        <property type="entry name" value="FI21270P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01694">
        <property type="entry name" value="BAIPRECURSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028557" description="Latrophilin Cirl" evidence="17">
        <location>
            <begin position="27"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="19">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="18">
        <location>
            <begin position="468"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="642"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="925"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1185"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="147444" checksum="72BB4E5927701037" modified="2025-10-08" version="1">MAWHGKFRPGLLLLLFSFVVISEATAKTLEIRYETAYACEGKILKIECKDGELIKLIRANYGRFSITICNDHGNTDWSVNCMSPKSLRVLHSRCSDKQNCTVEINNETFGDDPCPDTSKYIEAHYDCMSATTTTTTSRPSPPWLITSQPPMWSTIKAPSSRPTHPTPPPKPAVISLPQTPGPSTSRTKSTSTTRYFSVTPPPQLPVQPHNTGEFDEDAKLYPIPDEITTLPFTTVTPIGVESNKPTYDVMYTSVPSILPSWGKDSEGIPYHCSPQTVRSIYWNWTKVNATSIQPCPGGTTGFAKWHCQAFPNSKEPQWYPPNPDLSECRSVWLTSLEQRIIVGRDPLLSITNDLAQVTSSKTLFGGDMMFTTKIIQKLTEKMSKDIQTFPDAAQREQFVTELLSDVALTGSNLLDASQRSSWKDLSYKEQMNVATSLLIELEENAFLLAETVNNKKTVDRHFKNILLSVRVLDVKSLSYEVFPEGATKKHWKVSNDVIELPRGALIENSDGSLVRLVFVAFDRLEEILQWQPEGIDTPNPSNNVSKVLNSKVISASLGKGRHIQLKEPVKLTLQHLKIENVSNPTCVFWDYTTNAWSEEGCYVDYISSNLTHTTCYCDHLTNFAILMDVHAIYLPMAHEIALQVITYVGCIISIICLVLAIITFQLFRGLKSDRTTIHCNLCICLLIAEVIFLFGISQTENRIVCGVIAGFLQYFFLCAFFWMFFEGFQLYVMLIEVFEVEKSRMRWYYCIAYGLPFLIIFISAVIYPQGYGTYRHCWLQTDNYFIFSFVVPVAVIISLNVIFLIMAIVMMCKHSSNTVSMKNKEHSRLASTSGKEENALHIKIKAHFAWLKGAFILVFLLGLTWTFGFLYLNKESVAMAYIFAILNSLQGFFIFLFHCIQNEKVRKEYRKIIRRHSWLPQCLRCSSPSGGSGSTSGSSGMAKERRTSLYGGSNGNPSAGTNSHSTDNSVLTQHGTSLHRDWNSRSCTNVNRVCKTPVPTSTSANMAATLSRPIRTTPTNLIPDIDSNNTSTLPYFRNFYKISSNNPNIPKSISTWGPLHKPLHSKNISFKSCSRDSGHGGSEQEDSPRSHMVLVGNAVDPGPGHLITLNTKDIRHQMLQEQPTDLADFDICLEPNIHPKHLALPQNFHKRKPPGMSHHTYTEIYDSQIPRGLIEDDPVYEEIDRSEIQVSDMSDEDGKRQSDMSRQSSRSYGDHRPLIPYSPANERNFADVMKHYAKDLNHGPPSIGMDTYRRRNMAYRVGMTGDTSVRSLAAVLDGETVVCHLEPPENQYPNDTFVSRTLVLPPYSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXW1</accession>
    <name>A0A6P7EXW1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock 70 kDa protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114324396</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128024.1">
        <property type="nucleotide sequence ID" value="XM_028272223.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504964.1">
        <property type="nucleotide sequence ID" value="XM_050649007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EXW1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649007.1">
        <property type="protein sequence ID" value="XP_050504964.1"/>
        <property type="gene ID" value="LOC114324396"/>
    </dbReference>
    <dbReference type="GeneID" id="114324396"/>
    <dbReference type="KEGG" id="dvv:114324396"/>
    <dbReference type="InParanoid" id="A0A6P7EXW1"/>
    <dbReference type="OrthoDB" id="6718630at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24028">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028128024.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69389" checksum="14C204526B63CE58" modified="2020-12-02" version="1">MPKSIFDDDPIGIDLGTTFSCIAVYRKGKGEIIPDKNGDRLVPSVVFYDPENRNRILVGKAAEDEGPRRLENCIRDSKRIIGRKFDDYFVQEYISREDVQYKLEKGLYDKAVFKININKQSITKTPEEVSAEILKHLKEMAESFLNKKVFKVVISVPANFSNAQRKATKKAVDLAGLNLIRFISEPSAAGIHYIGDRYVQGNIMVFDWGGGTLDVSLVRVKNKTFEVQAVYGDTSLGGRDFDNQLFQYFHKKHVKKERSINKLRNACIELKKKLSNDEVATMFVDGYDNSEDYEITLTKKKFEFLNKNLLDRAMAVIITTLNQTGFKMYEIKRVLLVGGTTRIPKIRERIQHFFNDMNLTTDLNPDEAVAAGASLQAFRYKYDQGGVESFTVSEVTPLSLGLETLKDLMTVFIPRNSTLPITEVKTFTTTSNDQTLVTISIFEGERLNCDYNNKLGEFNITDLPPKKAGEVMVTVSFHLDEDGILTVSATECSSGKEKKLVVLMEEFRLSNRKVTMCIEDSQKMREEDEIFKEFVTTKHKFIEFCNHMLYDIRKINSIEERNMVQQNCDSFFKDISNLDFNQIARLKDLFVALTKKVEPILKKHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2L7</accession>
    <name>A0A6P7F2L7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear pore complex protein Nup154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114325659</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129576.1">
        <property type="nucleotide sequence ID" value="XM_028273775.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F2L7">
        <property type="interactions" value="2578"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273775.2">
        <property type="protein sequence ID" value="XP_028129576.1"/>
        <property type="gene ID" value="LOC114325659"/>
    </dbReference>
    <dbReference type="GeneID" id="114325659"/>
    <dbReference type="KEGG" id="dvv:114325659"/>
    <dbReference type="CTD" id="34527"/>
    <dbReference type="InParanoid" id="A0A6P7F2L7"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="7">
        <location>
            <begin position="74"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="6">
        <location>
            <begin position="621"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028129576.1"/>
        </source>
    </evidence>
    <sequence length="1334" mass="149938" checksum="D8887928E22E3524" modified="2020-12-02" version="1">MNTTTRVDNTQNPVQKIELTSRSIENALILDNNSPRLLDLMNISSQSGSTASGFADHDYPTISGVSQVINNMTQVKCVNSIPLPTEIVDHFSRVQCHCMMGLFCEINRAWLTVDSDIYVWTYEQNTDLAYFDGISETIVCVGLVKPKMGVFHAFIKYLLILATSVDIVVLGVTFTEKPGDTTEEIQLIPDPVFSLPTDGATVTIISSTNDGRIFYGTKEGKLFEIYYQAESGWFGQRCKKVNLSTSTLSFLVPSFLNAALSEEDGICQISIDESRHILYTLTEKGTIEVCDLGERGNTFSRIAKLGQNTLVNQAMNTVKTLDSQNFRPIVSISAIEATESANLNLVAVSQTGVRFYLTVVSLSNLQPNQRPYTLALAHVRLPPGYSANITVRPRAVHVSHYNDRNLVLISTVNDKDVLWCMSSDMFPFGQTLMEAYSVVNLDGPALAISEVRHPTPLPLPPNQEAPPLVVRQHAEPPKKYVVLTSHSVQIFIKLRPVDILNQILRDSQGLDTEALKTFFTIQKEDQACATCLILASLESDENVEVAEYATRAFFLYGGEPKLVPANIYAGPSVFAPQIISTPAPHNYQTQQYQTAQHFQPNMSQTAPNTTGYEFTGPFVFSAKHNSLYLYLSRILRPIWNMRTVDKLSVDGKVSTTYSTVSSDDCIFILNNLTALHNFLARNTQLSTMSKNQNQFQNSTLNNTSLNMTRMNHTVQDAQMEEKASLNSFKILVSLCCQILGLWRILCEHQFHSLVASLTENEQQILVNTTFKDLFLYRHDICSSLISALVQTYLGDNASVDSISSKLREVCPQMYKTEDMAYSKAIEILKSARTIQNVGEKEELLNSALQICKSIGPNLNIGDVCKEFCNLKGYKAVTELCCHYASKLDPENIAEIYYNAPDSTGDQEGYNYYQNRMEIYRHLLNMLNAMYQELNVTPVPCLNYDLDFSVTQSILTDTPEQSQIGYMMKQVITDILQTPDQIMHINLYDWLISKNMTGDLLTINNDSLETYLKRTAAQNPNDTVALDLLWKFYEHRNDHAAAAKILNSLASRTGVNIPLKERLAYLARSIMCMRSDKIGYAPYLGVFLRDLEDKLEVAKVQEQILEAVMNQQNQIENYGDIVTALNSGLFEISQLYENFAEPFKLLECQLAIIDCAGYTDPALIETIWQQILTDELKKTTGTGTDKVCQLLNKVKHLAKYYAKSMNCFPLDYIIYELEIVNAKLRGDRQLVPTALESMNIPFDSLIAVYNNLNTISGNDHFWQLEENEFHLCEATATLISCFISNQDSYSSIEKRKYISLSQDTVVALLSNLYSKPNTEAIVNKLRNIQARLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F346</accession>
    <name>A0A6P7F346_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Myosin heavy chain, muscle isoform X8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114326036</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130079.1">
        <property type="nucleotide sequence ID" value="XM_028274278.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F346">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274278.2">
        <property type="protein sequence ID" value="XP_028130079.1"/>
        <property type="gene ID" value="LOC114326036"/>
    </dbReference>
    <dbReference type="GeneID" id="114326036"/>
    <dbReference type="CTD" id="35007"/>
    <dbReference type="InParanoid" id="A0A6P7F346"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007298">
        <property type="term" value="P:border follicle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14909">
        <property type="entry name" value="MYSc_Myh1_insects_crustaceans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000038">
        <property type="entry name" value="Myosin heavy chain muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000005">
        <property type="entry name" value="Myosin heavy chain, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000050">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="87"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="893"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1824"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1922"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1925"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028130079.1"/>
        </source>
    </evidence>
    <sequence length="1965" mass="224571" checksum="A29C7C4D6A25B468" modified="2020-12-02" version="1">MPKPQKQEGDDPDPTPYLFVSLEQKRIDQTKPYDAKKSCWVPDDKEGFLLGEIKGTKGDLVTVGLPGGEEKNFKKDQVTQVNPPKYEKAEDMSNLTYLNDASVLHNLKQRYYHKLIYTYSGLFCVAINPYKRFPVYTNRCAKLYRGKRRNEVPPHIFAISDGAYVNMLTNHENQSMLITGESGAGKTENTKKVIAYFATVGASTKKDADPNQKKGNLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQPLERSYHIFYQIMSGSVPGVKDMCLLSNDIYNYYYVSQGKITVPNMDDGEEFSLTDEAFDILGFTQEEKDNVYKITAAVMHMGCMKFKQRGREEQAEPDGTEEGERVSKLLGVEAPALYQALVKPRIKVGNEFVTQGRNVNQVSYSVGAMSKAMFDRVFKFLVKKCNETLDTKQKRQHFIGVLDIAGFEIFDYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYTREGITWVFIDFGMDLAACIELIEKPMGILSILEEESMFPKATDKTFEEKLNTNHLGKSPNFQKPKPPKPGQQAAHFTLGHYAGNVPYNITGWLEKNKDPLNDTVVDLYKKGSNALVVEIFADHPGQSGGAAEKGGKRTKGSAFQTVSSLYREQLNNLMTTLRSTQPHFVRCIIPNELKQPGVIDSHLVMHQLTCNGVLEGIRICRKGFPNRMVYPDFKLRYKILNPAAVSKESDPKKCAEHILDASGLDAELYRLGHTKVFFRAGVLGQMEELRDDRLGKIVTWMQSWVRGYLSRKEFKKLQEQRLALQVCQRNLRKYLKLRTWPWYKLWQKVRPLLNVTRIEDEIAKLEEKAQKAQEAFEREEKAKKELEALYAKLLAEKTELLSNLEGEKGSLSETQERANKLQAQKNDLESQLSETQDRLSQEEDARNQLMQQKKKLEQEMSGFKKDIEDLELNLQKSEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMSGENNQKVSEELQAAEDKVNHLNKVKAKLEQTLDELEDSLEREKKLRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKEISSLTAKLEDEQSVVGKQQKQVKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELAKLRRDLEESNIQHEGTLANLRKKHNDAVSEMGEQIDQLNKLKAKAEKEKSQYFGELNDLRASVDHLANEKAAIEKVSKQLGQQLNDVQGKLDETNRTLNDFDAAKKKLSIENSDLLRQLEEAESQVSQLSKIKVSLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNIREQVEEEAEAKADIQRQLSKANAESQLWRQKYESEGVARSEELEEAKRKLQARLAEAEETIESLNQKVVALEKTKQRLATEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRSQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKTIKRYQQQLKDTQTALEEEQRARDEAREQLGISERRANALQNELEESRTLLEQADRARRQAEQELGDAHEQLNDLGAQNASLSAAKRKLETELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEAQIKDLQVRLDEAEANALKGGKKAIAKLEQRVRELENELDGEQRRHADAQKNLRKSERRIKELSFQAEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAIAKFRAKGRSGSAARGASPAPQRQRPTLGMGDALGGPFPPRFDLAPDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F865</accession>
    <name>A0A6P7F865_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-ribosomal protein eS31 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327318</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131706.1">
        <property type="nucleotide sequence ID" value="XM_028275905.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500383.1">
        <property type="nucleotide sequence ID" value="XM_050644426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F865"/>
    <dbReference type="FunCoup" id="A0A6P7F865">
        <property type="interactions" value="1680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275905.1">
        <property type="protein sequence ID" value="XP_028131706.1"/>
        <property type="gene ID" value="LOC114327318"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644426.1">
        <property type="protein sequence ID" value="XP_050500383.1"/>
        <property type="gene ID" value="LOC114327318"/>
    </dbReference>
    <dbReference type="GeneID" id="114327318"/>
    <dbReference type="KEGG" id="dvv:114327318"/>
    <dbReference type="CTD" id="6233"/>
    <dbReference type="InParanoid" id="A0A6P7F865"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131706.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17920" checksum="B4C02355077E9A60" modified="2020-12-02" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKNYSTPKKIKHKKKKVKLAVLKFYKVDENGKIHRLRRECPAEQCGAGVFMAAMEDRHYCGKCGYTLVFSKPGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9B6</accession>
    <name>A0A6P7F9B6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114327912</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132424.1">
        <property type="nucleotide sequence ID" value="XM_028276623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9B6"/>
    <dbReference type="FunCoup" id="A0A6P7F9B6">
        <property type="interactions" value="1769"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276623.2">
        <property type="protein sequence ID" value="XP_028132424.1"/>
        <property type="gene ID" value="LOC114327912"/>
    </dbReference>
    <dbReference type="GeneID" id="114327912"/>
    <dbReference type="KEGG" id="dvv:114327912"/>
    <dbReference type="CTD" id="34264"/>
    <dbReference type="InParanoid" id="A0A6P7F9B6"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000232">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028132424.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49967" checksum="478C1F82BDFE5D9C" modified="2020-12-02" version="1">MDEEYDCIVLGTGLKECILSGMLSVSGKKVLHVDRNKYYGGESASICPLEELFSKFGVPPPDESYGRGRDWNVDLIPKFLMANGMLVKLLIHTGVTRYLEFKSVEGSYVYKGGKIAKVPVDQKEALASDLMGMFEKRRFRNFLIYVQDFQADDPKTWKDFDPNTQNMQALYEKFGLDKNTQDFTGHALALHRDDDYLNRMAVETINRIKLYSDSLARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDKPIDEIVLGEGGKVVGVRSGNEIAKCKQVYCDPTYVSDKVRKKGKVIRCICLLDHPIANTRDALSTQVIIPQKQVGRSSDIYVSVVSYTHQVAAKGWFIAMVSTTVETENPEIEIKPGLDLLGIIRQKFVSVSDYYEPTDDGLQSQIFISQSYDATTHFETTCLDVLDIFKRGTGEEFDFSKIKHELGDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9P6</accession>
    <name>A0A6P7F9P6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Protein UXT homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114328033</name>
        <name evidence="4" type="synonym">LOC114340106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132574.1">
        <property type="nucleotide sequence ID" value="XM_028276773.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146636.1">
        <property type="nucleotide sequence ID" value="XM_028290835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9P6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276773.2">
        <property type="protein sequence ID" value="XP_028132574.1"/>
        <property type="gene ID" value="LOC114328033"/>
    </dbReference>
    <dbReference type="GeneID" id="114328033"/>
    <dbReference type="KEGG" id="dvv:114328033"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028132574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028146636.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17745" checksum="3A0636E889FA6E9B" modified="2020-12-02" version="1">MNVKEVQEKVKEYENFIEDKLKPDLEDIVVILKDKSTKLKDWEEVKTTVKTVRRSKEKDRDMVVKVDIGGGILAQGEISDLEQIYVDVGLGYMLEMNHQEADRYADIRMNLLKKEIAHFRKMAVDVKVNIKLILLALSELQATVTPTNLLTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9Q1</accession>
    <name>A0A6P7F9Q1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114327174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114327174</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131512.1">
        <property type="nucleotide sequence ID" value="XM_028275711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9Q1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275711.2">
        <property type="protein sequence ID" value="XP_028131512.1"/>
        <property type="gene ID" value="LOC114327174"/>
    </dbReference>
    <dbReference type="GeneID" id="114327174"/>
    <dbReference type="KEGG" id="dvv:114327174"/>
    <dbReference type="InParanoid" id="A0A6P7F9Q1"/>
    <dbReference type="OrthoDB" id="6779463at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028131512.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20924" checksum="D4442701670B652C" modified="2020-12-02" version="1">MNSSFPDPGWKLCPSLNSQIQYVCYATEQCCLTGCCTPFVYKQFKSWSFWLILLIVGAFLYCCWWFCKILKESRKKRQRNLLSRNMFLSTNSINGSPRTQGHIVDLFNCRENASSTKLSKSGDAPPKYRDALKMPRRQDTQTVEIHCDNQLTSVENNTETTASTSGDPPTYEDAKKYQNEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB58</accession>
    <name>A0A6P7FB58_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cytosolic iron-sulfur protein assembly protein Ciao1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114326495</name>
        <name evidence="4" type="synonym">Ciao1</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130690.1">
        <property type="nucleotide sequence ID" value="XM_028274889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499398.1">
        <property type="nucleotide sequence ID" value="XM_050643441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB58"/>
    <dbReference type="FunCoup" id="A0A6P7FB58">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643441.1">
        <property type="protein sequence ID" value="XP_050499398.1"/>
        <property type="gene ID" value="LOC114326495"/>
    </dbReference>
    <dbReference type="GeneID" id="114326495"/>
    <dbReference type="KEGG" id="dvv:114326495"/>
    <dbReference type="CTD" id="9391"/>
    <dbReference type="InParanoid" id="A0A6P7FB58"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000136">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028130690.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37520" checksum="F2D11D83E36870AC" modified="2020-12-02" version="1">MGKLELVQTLKKDNGRVWNLDWHPKGDSLASCGEEKSIRIWTKDLTGKWSNRVVLTDGHKRTIRQVSWSPCGNYLASGSFDATTCIWDKKSGEFECNATLEGHENEVKSIAWSKSGHLLATCSRDKSVWVWEVADEDEYDCAAVLNAHSQDVKKVIFHPEKDLLASASYDDTIKLFRDDPNDGDWVCCGTLAGHESTVWSISFDKTGTRLASCSDDNTVKIWKEYPPGNPEGIATQDGDSAWKCVCTLSGHHERTIYDIHWCHLTGFIATASGDDAIRIFKEEEGCDPNSPNFNLVCVVDNAHNQDVNCVTWNPVVPGLLASCSDDGEIKIWEFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ88</accession>
    <name>A0A6P7FJ88_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing G-protein coupled receptor 4-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114330811</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136021.1">
        <property type="nucleotide sequence ID" value="XM_028280220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJ88"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280220.2">
        <property type="protein sequence ID" value="XP_028136021.1"/>
        <property type="gene ID" value="LOC114330811"/>
    </dbReference>
    <dbReference type="GeneID" id="114330811"/>
    <dbReference type="KEGG" id="dvv:114330811"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027535452" evidence="3">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028136021.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36406" checksum="7E4BF4A2A31321DA" modified="2020-12-02" version="1">MIQLTCKLLIFLFVIQGVYSFCENKDAFNNVTVDVHISRNISSIKLVQQDHYSIIDVKQGNITDLCDGMINNFPVLDTLLLINVNLSRIQPNAFQVVPRLRELSLAVNHIEDLVDGSFNNLDALETLYLSANKIKYIDGETFQNMKSLKHLHLDRNLINKLSPNCLRGSSLLSMLDLRHNLMEVVDGSTFPVIEPIFTDPVTIFLGNNYIKDVDPSVFTFKNPVNLHLERNNLNTVSTLFYGMREYSVLYLNKNQFNCLPDDVLENLKKTTKTIYLLDNPISCDCLKTIEKSFADELYGVEHLIYNSSFPCDMPVFLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FM65</accession>
    <name>A0A6P7FM65_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein hook</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114330783</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with microtubules via its N-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hook family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135992.1">
        <property type="nucleotide sequence ID" value="XM_028280191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FM65"/>
    <dbReference type="FunCoup" id="A0A6P7FM65">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280191.2">
        <property type="protein sequence ID" value="XP_028135992.1"/>
        <property type="gene ID" value="LOC114330783"/>
    </dbReference>
    <dbReference type="GeneID" id="114330783"/>
    <dbReference type="KEGG" id="dvv:114330783"/>
    <dbReference type="CTD" id="35169"/>
    <dbReference type="InParanoid" id="A0A6P7FM65"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000024">
        <property type="entry name" value="Hook homolog 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF39">
        <property type="entry name" value="PROTEIN HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="14">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="256"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028135992.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="71973" checksum="C75C6761A2B74405" modified="2020-12-02" version="1">MDPSEDMCKSLAKWLQKIVPNKTRTIPEICDGVGMVDALLQISPEHFSKLESKIKRDVGANNWRLRISNLKKIVEAVIEFYQDVLTLQVLDIGVPDVNQIGENNDPVQLAKLLRLILGCAINCERKQEYITMIMDMEESIQQNIMQAIQQLDQVTGGQGRSGLSLLILDSDTRVMKLVSDLESSNKSREALTQQVETLEQQIQTLLDEKRSLHEQNQMLIEKEAKNPQENIRKQLESLKDELFKSEVIREDFKGKLFEQEKQILTYQEKINELQIAANESAKLKDEIDALTESAGKVVDLELTVASYKKRLENYQDIKRNLQKLEEKQMEYIQKNMELEEELSKNSTWKAQCEVYKNQIVELQQKLDEEAQKADKAQFNLDKIKAKLISLQGEKERLILERDTLKEENEELKLGPRESGAAVSQELTPTEMEKRLKLMEKENKTLRSSSQEMESKQLQLDSALNRIEKLQQKNRTLNQTVLKLEAQVEELKTQQSEVQGTSSGSSIVKEYRQKIIAYQEALASKDNELQSLQTKYNRNVGRAREVAQQLEFKSNGDSDNASLRQSNIKELEERLITAAFNKLSLNCHRESMDERLSVLHGGQGQSFLSRQRQPTPRKPIQRFKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FN84</accession>
    <name>A0A6P7FN84_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329539</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329539</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134485.1">
        <property type="nucleotide sequence ID" value="XM_028278684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FN84"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278684.2">
        <property type="protein sequence ID" value="XP_028134485.1"/>
        <property type="gene ID" value="LOC114329539"/>
    </dbReference>
    <dbReference type="GeneID" id="114329539"/>
    <dbReference type="KEGG" id="dvv:114329539"/>
    <dbReference type="InParanoid" id="A0A6P7FN84"/>
    <dbReference type="OrthoDB" id="10435407at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027695194" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028134485.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15875" checksum="D9AA4EFFA5E709C1" modified="2020-12-02" version="1">MKLMLFFFVALTVVASQAEEFNVFEKYVEFVPQCNSTLSNQAFKDFMTKKNANLGLEELGNFLFCMNTKFLTQNENGDVNVQQFNKIVGTLVPQNKLEHLTTVCARRPEGHTATQTALFLLKCLQKEGMDFSPIMNLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPA1</accession>
    <name>A0A6P7FPA1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase D C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114331292</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136617.1">
        <property type="nucleotide sequence ID" value="XM_028280816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280816.2">
        <property type="protein sequence ID" value="XP_028136617.1"/>
        <property type="gene ID" value="LOC114331292"/>
    </dbReference>
    <dbReference type="GeneID" id="114331292"/>
    <dbReference type="KEGG" id="dvv:114331292"/>
    <dbReference type="InParanoid" id="A0A6P7FPA1"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF3">
        <property type="entry name" value="FI03431P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028148389" evidence="2">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028136617.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54246" checksum="819FA1120BF3D9D1" modified="2020-12-02" version="1">MKLSFIFELLLIFILVAFAASAAVDNKSIKAKKKVVHYGTKITRTRQNQNVSQTVVAQAQQPVQQNPPNRFCTCAKQMCNCCRDFNLKLLNLKGPGCAVLQYLQGDQLAISMSFNDRVLTNTTIKGRKPPPICMPLPGGISKFCGRVYNIGRQGEEFNACLGLELRALNDVEAAIRVSCFRFGPNGLRLEPPQPLPPVDNDNDDDDDDDDDDDDDDDDDDDDDFGFDGDDDDDSDGDSVDYSVFDDDFIGEYFQGEDDSSSSSNKNKVSTTTTPKPLRRNTRKPIHKPVEKKPIRRKSKPQLQQTVTTPKTVITKKPVGPVKKATKIPHHRRTTKPVTESSKPTTNAPMPQNQPSTEITSDTNVNVSVNPIISTSLPPDTPIPTTEEQKTEATSPKIRTGITDSIKTSQTIVPVTKVQELSSEESEDPIADMVEDAIEDEISDSTENTTTQTKKVTVMTSPQPKESTEVFDEVVDGVVDTFAGEESEEARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FT47</accession>
    <name>A0A6P7FT47_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuropeptide-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114332370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137957.1">
        <property type="nucleotide sequence ID" value="XM_028282156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FT47"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282156.1">
        <property type="protein sequence ID" value="XP_028137957.1"/>
        <property type="gene ID" value="LOC114332370"/>
    </dbReference>
    <dbReference type="GeneID" id="114332370"/>
    <dbReference type="KEGG" id="dvv:114332370"/>
    <dbReference type="InParanoid" id="A0A6P7FT47"/>
    <dbReference type="OrthoDB" id="10494847at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028137957.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10461" checksum="EC7649334B686230" modified="2020-12-02" version="1">MVTSIIKFDCMSQNVLLVFKKLKILQYTKMFKAVFLFFAMLAVAFAAPRPAPAPQLLAYSAPAAVVSDVTFTGYPAVAPVYSAGVAPVAYSAPLVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX43</accession>
    <name>A0A6P7FX43_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335150 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335150</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141124.1">
        <property type="nucleotide sequence ID" value="XM_028285323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX43"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285323.2">
        <property type="protein sequence ID" value="XP_028141124.1"/>
        <property type="gene ID" value="LOC114335150"/>
    </dbReference>
    <dbReference type="GeneID" id="114335150"/>
    <dbReference type="KEGG" id="dvv:114335150"/>
    <dbReference type="InParanoid" id="A0A6P7FX43"/>
    <dbReference type="OrthoDB" id="6747438at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141124.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38677" checksum="6D27EF0C9FE05B6C" modified="2020-12-02" version="1">MSKKNYLFIRCIIFLWATGCVVVAEHQKRDVHRIILQERVPRSHKSHSHHNHSRGKRKGHGHKQGKRNSDESYSLSVEDNQSFEDIFKNHKNHHQHHNDPIFTNPHFGSTLDHQESRHHPFKEELQPFYGSEWTPINYENQHSHELHHREKDRRTKRRPKKPNYKHPHKHYGDYVNSPSKVLGKPFIELGNSEHLGSIHHSGPSNNLPPTFPSSLESSTLYPPIDVLSTFSALNKQLLETNPPNLEDGEPKEDPDRLKNHKSSYDVQESVASELGTVIYMPDTTPAEFSPLEFSHQGPSFHQGPSPHQGPSPSLKFEAKPNTRHRGSKKFNSRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZR0</accession>
    <name>A0A6P7FZR0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC114334437</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13 14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028140276.1">
        <property type="nucleotide sequence ID" value="XM_028284475.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140277.1">
        <property type="nucleotide sequence ID" value="XM_028284476.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140278.1">
        <property type="nucleotide sequence ID" value="XM_028284477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284475.2">
        <property type="protein sequence ID" value="XP_028140276.1"/>
        <property type="gene ID" value="LOC114334437"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284476.2">
        <property type="protein sequence ID" value="XP_028140277.1"/>
        <property type="gene ID" value="LOC114334437"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284477.2">
        <property type="protein sequence ID" value="XP_028140278.1"/>
        <property type="gene ID" value="LOC114334437"/>
    </dbReference>
    <dbReference type="GeneID" id="114334437"/>
    <dbReference type="KEGG" id="dvv:114334437"/>
    <dbReference type="OrthoDB" id="6696619at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="46"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028140276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028140277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028140278.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="55388" checksum="AAF93FD50857E987" modified="2020-12-02" version="1">MDNKPVASNDESYTEDENAMMEKNFSIENLPLKIEIEQKKPDTFFLLFMVIAGSMTNAVSGAHLVWTSPVVPKLKSDISDDNPIGRPATTLEISMIAGFAPLAMIGGSLVLGTLSELLGRKRSLQLLAVGIFLANAVLAFSNNIVLIIVSRSILFFFFNGTMTIYPVYLTEICEDHNRAKYGCLMGVFLPFGSLLSYALGSFFSVRIYTLLLSGPLILFLAFFFLAPESPVYSLSKGRRNECLQTLMKLRSNKTEKEIMVDMYKIEETIRAKDSGTSANSMASVFSTKERRYALMLALIPVAMQPLSGVLVTLQFLAPLFIAAGSKYDSNHMSIIVGSIELSSFLLTTCIIERTGRKPMLLISSIGIGITHFVLGLYFYLKYIECSFISSIHLLPLACVINLILMYSLGLGPIPMAIMGELFTPDIRTKALSLIMTVLGIGSFATTSSYPFMVEYLGMHWCVWINSLCCIAGATFIYVMIPETKGKSIVQIQEYIKTKCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0T5</accession>
    <name>A0A6P7G0T5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Angiopoietin-related protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114334775</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140667.1">
        <property type="nucleotide sequence ID" value="XM_028284866.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513139.1">
        <property type="nucleotide sequence ID" value="XM_050657182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0T5"/>
    <dbReference type="FunCoup" id="A0A6P7G0T5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657182.1">
        <property type="protein sequence ID" value="XP_050513139.1"/>
        <property type="gene ID" value="LOC114334775"/>
    </dbReference>
    <dbReference type="GeneID" id="114334775"/>
    <dbReference type="KEGG" id="dvv:114334775"/>
    <dbReference type="InParanoid" id="A0A6P7G0T5"/>
    <dbReference type="OrthoDB" id="10666173at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027803693" evidence="3">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="197"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028140667.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47985" checksum="D50B0A55D0187ACF" modified="2020-12-02" version="1">MKSLAIMLLLCGNLKIALSETVPAADPNNVKFRKCVDFTAEGGANSWKEDLRTFLYPEKEAFDLGTKEDNEKFRMMSSAVVDKLNSLQEYENTLKNVSDKLNSLKEYENTLKNTLVSSLKEYENTFKNTLLNSLQEYENTLKPVFDKLNISEEYENTKHTFDKLNIVQKNVFDKCKYLVGKSQIPFCGLNPEQPFSEAEDAYPRSCKEILKSGKNKSDVYIIKPKRSIKPFAVLCDMETKGGGWTHIQKRFDGSQDFYLPWRDYKFGFGDLRGEFWIGLENIYHMTDFQFQSSELLVELTDTDQKNYYAQYTSFSIGNEKDGYILNKLGNYSGLDGEDNLNYHLNAKFSTLDVDQDSSSDNCAQKFDGAWWYVDCHRSNLNGKFMTVVLPKTYRLKGLRWGELENGGNLAGSRMMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0Y4</accession>
    <name>A0A6P7G0Y4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 302a1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114336405</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142564.1">
        <property type="nucleotide sequence ID" value="XM_028286763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0Y4"/>
    <dbReference type="FunCoup" id="A0A6P7G0Y4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286763.2">
        <property type="protein sequence ID" value="XP_028142564.1"/>
        <property type="gene ID" value="LOC114336405"/>
    </dbReference>
    <dbReference type="GeneID" id="114336405"/>
    <dbReference type="KEGG" id="dvv:114336405"/>
    <dbReference type="CTD" id="45282"/>
    <dbReference type="InParanoid" id="A0A6P7G0Y4"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000006">
        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028142564.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="58089" checksum="E59983A5CDDDCAAA" modified="2020-12-02" version="1">MSIFKKNVFIVNCLFKVRRHIVIRRYVHDFKSIPGPKSLPAIGTLYQYFPLIGNYRFDELPSNGLKKYNKYGPIVREEIVPGVNVVWLFDPKDIETLFRQEGKYPQRRSHLALEQFRLDRPNVYNSGGLLPTNGPEWFRIRSVFQRGLSIQSVKKFINSVNSIIQEWLIHVESMENNPELDFLPELSRLFLELTGQTTLDIRLNSFTPRERGKHSRSSRLIKAAEVTNSCILKTDNGPQLWRKFDTPLYKKLKYSQTFMEQVAIDLIALKMSLFTDRENSQPSLLDSYLSSPEVDFKDIIGVVCDFLLAGIDTSAYTTSFVLYHIANSPSVQENIYNEAHKLLPKQHSRVTEEILSEAVYTKAVLKESLRLRPISVGIGRISQNDAQFSGYTVPAGTSIVSQNQISCQLDKYFPRAEKFVPERWLKNHPLYHQPHPFLLLPFGHGPRSCVARRLAEQNMIILLLKVFRNFRIRWRGGRLDSKSYLINKPDGPILLEFIKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2M7</accession>
    <name>A0A6P7G2M7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase</fullName>
            <ecNumber evidence="11">2.4.2.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114336946</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1-&gt;3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56064"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:14611"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:140575"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
            <dbReference type="EC" id="2.4.2.42"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.42" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028143161.1">
        <property type="nucleotide sequence ID" value="XM_028287360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2M7"/>
    <dbReference type="FunCoup" id="A0A6P7G2M7">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287360.2">
        <property type="protein sequence ID" value="XP_028143161.1"/>
        <property type="gene ID" value="LOC114336946"/>
    </dbReference>
    <dbReference type="GeneID" id="114336946"/>
    <dbReference type="KEGG" id="dvv:114336946"/>
    <dbReference type="CTD" id="43008"/>
    <dbReference type="InParanoid" id="A0A6P7G2M7"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140563">
        <property type="term" value="F:UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051993">
        <property type="entry name" value="Glycosyltransferase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46012:SF2">
        <property type="entry name" value="IP22168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028143161.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="43649" checksum="FE2388CA9A91EB31" modified="2020-12-02" version="1">MRLYTILQLGILLSIALVIFYLYSIRLINTTDILEEAEFEEVVEDNEVTTERIYFKKSDIVVAVVACGDRLFETLNMLKSALMFSKEKLNFIIVSEERLIDSFNEKLGEWKAFMNNGFTFKVLPLTFPSDNPLEWKKLFKPCAAQRLFLPNLLENVDSILYMDTDTLFLTPVETVWEHFNRFNSSQMAALAPEHEDPNVGWYNRFAKHPYYGKLGVNSGVMLMNLTRMRAFQWKEYVVPIYKKYKLKITWGDQDIINIIFHYHPDKLYIYSCRFNYRPDHCMYTSVCKPAESEGVAVIHGSRGFFHSEKQPIFQAVYRSFEEYPLGGDIYREFYQLLETYLDNSQNNNCGNVKDIFLKNIRKYIDLDVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3X4</accession>
    <name>A0A6P7G3X4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuole membrane protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114337420</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143679.1">
        <property type="nucleotide sequence ID" value="XM_028287878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3X4"/>
    <dbReference type="FunCoup" id="A0A6P7G3X4">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287878.2">
        <property type="protein sequence ID" value="XP_028143679.1"/>
        <property type="gene ID" value="LOC114337420"/>
    </dbReference>
    <dbReference type="GeneID" id="114337420"/>
    <dbReference type="KEGG" id="dvv:114337420"/>
    <dbReference type="CTD" id="326232"/>
    <dbReference type="InParanoid" id="A0A6P7G3X4"/>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028143679.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53454" checksum="6F763F9941E83FAF" modified="2020-12-02" version="1">MPVKKNRKARPAFSTQNTKQTSTGNPPKNLKISDELLYLNKEQLKIECRKRGQKTTGTKNELLQRLGKTMAGHGKKKDATGSHHMNGGSTTQTKNKKHTDTQKKEKEKNERESLVLWRKPLRTVEYFIRECIELATIYGKKILASKVILGVISLSVLLLYILVNSKGPHQALVQGVYKQLLWCSYWVGLGILSSVGLGTGLHTFLLYLGPHIAQVTLAAYECGSLDFPEPPYPDEIVCPTDGKVGVISFLSIMSKVRLEAMCWGAGTALGELPPYFMARAARLSGIDPDDEDEDLKAFEELEKKKKHHRNELTLVEKGKLFVEDIVQKVGFLGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKAIIKMHLQKMFVIIAFNETLIDTALDWLKLVPVVGEKLQVPFKAFLNGQKQKLHKNAPVTTEGGNILGSIFEKFVIAMVLYFVISIVNSFAQSYHKRINKKKNTKASKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6W8</accession>
    <name>A0A6P7G6W8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114334427</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334427</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140265.1">
        <property type="nucleotide sequence ID" value="XM_028284464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6W8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284464.2">
        <property type="protein sequence ID" value="XP_028140265.1"/>
        <property type="gene ID" value="LOC114334427"/>
    </dbReference>
    <dbReference type="GeneID" id="114334427"/>
    <dbReference type="KEGG" id="dvv:114334427"/>
    <dbReference type="InParanoid" id="A0A6P7G6W8"/>
    <dbReference type="OrthoDB" id="8182951at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027535809" evidence="1">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140265.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29510" checksum="48D255479566FF9E" modified="2020-12-02" version="1">MIKMNSSVMKILLCTGLAILLFDVVVVTGQEVTLTFELDNKLDGDVKGTTEKVSSPKPDEKSKSVSKVEPKYICPGKEAQLPLFALPCSTKKDCGIFGKTVLCCDKRCINGVKPPKPEPTHSPTLFGFVQQTCPKEPLAEIFEVKECSSDEECAPRICCPETLRSGETVSYCRTAQPLWETIPAPRQLVEPFRALVSYMQCTAPPPPLLDLFPKPCESPLDCFPNLCCQEGGKKFCRPPKRSLLTLIAGIGQRIIPTEAAKEFIKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8T8</accession>
    <name>A0A6P7G8T8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Esterase AGAP003155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114334974</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140910.1">
        <property type="nucleotide sequence ID" value="XM_028285109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8T8"/>
    <dbReference type="FunCoup" id="A0A6P7G8T8">
        <property type="interactions" value="1107"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285109.2">
        <property type="protein sequence ID" value="XP_028140910.1"/>
        <property type="gene ID" value="LOC114334974"/>
    </dbReference>
    <dbReference type="GeneID" id="114334974"/>
    <dbReference type="KEGG" id="dvv:114334974"/>
    <dbReference type="InParanoid" id="A0A6P7G8T8"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000073">
        <property type="entry name" value="esterase OVCA2 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028140910.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28500" checksum="556F13FC82534423" modified="2020-12-02" version="1">MNHENIEPQKCCPNDKMKLKILAIHGYRQNAETFRSKTGSFRKMIHKWAEFTYITAPHKVILVDDPNDLEKNGPDIGQSKDEEQYGWFFNRDDKTFRGIRKGGPAIGFEDSLKYIEDICEKEGPFDGLLGFSQGACFAGLLCDLQQRGLSKFTFNFAIFSSGFKSGSLPHLKYYIDRITIPSLHIFGENDQIIPTDMSEALSNCFEEPFIVRHPGGHYLPASAPQKSDYQKFIKLQLLKKQCNNLTFNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEN2</accession>
    <name>A0A6P7GEN2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114336390</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142550.1">
        <property type="nucleotide sequence ID" value="XM_028286749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663560.1">
        <property type="protein sequence ID" value="XP_050519517.1"/>
        <property type="gene ID" value="LOC126893412"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GEN2"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028142550.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40883" checksum="DB7D86B35DFFFF02" modified="2020-12-02" version="1">MKSDTENESTQNRGKEERSKRSKKIPIPLSPRVKQRMLILTKRLRSSRNKITTRREIRELAKVPLPSTSSDERHTPDRDNFLLTRSVSDTDLSWQSAENLTKASARSHSVGYSSALERTKSLEDFSDMTAYGELIMDQPPNTSNANQSTSKPKDHLYKILVIGDLGTGKTSIIKRYVHRFFTQHYRATIGVDFALKVLNWDENTLIRLQLWDIAGQERYGNMTRVYYKEAVGAFIVFDVTRKPTFESVANWKADLDSKVQLPDGSKIPCVLLANKCEQPKEGIASSPTKMEEYCRENGFHAWFETSAKDNINIDEAASCLVEKILAYDSVINSDSKRSSDQFSLRRDSDGNSSSRRSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEY7</accession>
    <name>A0A6P7GEY7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable trafficking protein particle complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114337344</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143553.1">
        <property type="nucleotide sequence ID" value="XM_028287752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEY7"/>
    <dbReference type="FunCoup" id="A0A6P7GEY7">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287752.2">
        <property type="protein sequence ID" value="XP_028143553.1"/>
        <property type="gene ID" value="LOC114337344"/>
    </dbReference>
    <dbReference type="GeneID" id="114337344"/>
    <dbReference type="KEGG" id="dvv:114337344"/>
    <dbReference type="CTD" id="39769"/>
    <dbReference type="InParanoid" id="A0A6P7GEY7"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028143553.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16431" checksum="A4FB58654C87431E" modified="2020-12-02" version="1">MIGTYYFVIVGHNDKPLFEMEFTNSKDSKKEDHRHLNQFIAHSALDLIDEHQWKSHAMNLKSVDKFNQWFVSAFVTASLIRFVIVHDNRNDDGIKNFFSEIYEAYIKHSMNPFYEEDTPIKSPAFEKKVQIHGKKYLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF17</accession>
    <name>A0A6P7GF17_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114336480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114336480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142655.1">
        <property type="nucleotide sequence ID" value="XM_028286854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF17"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286854.1">
        <property type="protein sequence ID" value="XP_028142655.1"/>
        <property type="gene ID" value="LOC114336480"/>
    </dbReference>
    <dbReference type="GeneID" id="114336480"/>
    <dbReference type="KEGG" id="dvv:114336480"/>
    <dbReference type="InParanoid" id="A0A6P7GF17"/>
    <dbReference type="OrthoDB" id="6702328at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027580168" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028142655.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16959" checksum="4E55DCD623F218D8" modified="2020-12-02" version="1">MQKALISLAVLSLVQLSYAALPVREFGEPMKTDFQMWHDNCEIYIPGVTQKEIDRVRQGHFDTENQAIKNYAACVWLESKGINLDMIMNKAILDLYLPRKVEEDEYIGYLLCAKENRDKKVSFVDKIWGMLECNYKRNPNDFIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFB7</accession>
    <name>A0A6P7GFB7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114341691</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341691</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148301.1">
        <property type="nucleotide sequence ID" value="XM_028292500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292500.2">
        <property type="protein sequence ID" value="XP_028148301.1"/>
        <property type="gene ID" value="LOC114341691"/>
    </dbReference>
    <dbReference type="GeneID" id="114341691"/>
    <dbReference type="KEGG" id="dvv:114341691"/>
    <dbReference type="InParanoid" id="A0A6P7GFB7"/>
    <dbReference type="OrthoDB" id="6764048at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="157"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148301.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43620" checksum="C207B6478758E48D" modified="2020-12-02" version="1">MKPNYRNSSSTPYSGAPAAYRRSGSSPRGKYSRRSGSSRPPWARESRGRSYYRGKKSPPPRPLPGINLMIALVEYPKSLMSEEQLAILEEQILEAIDKIEDGTFRPQFLECKRETGSLILRCNNDLTVNWLKETLSTLGLWEGAELKIVDSVPNTSKDISKVIVPKNYPLEFFNTEQLDKLQSDILKEIDNIPDGSFMPQFLSCLKERGALKFNCNNLASAEWLRTTVPTLENWKDEDVSILDPETVPVRSTLQLWIPGAVEEPEQVLERLERQNKGLDTLNWQVLNKKVEEGGQKLFVTVQDHVLDALKKIDYNPFLNFTRVKVKRLGRYKPREKKDEKNEDPDTAYIETKEDPMAGDIGEFTAIDEIKEEEEDKAVPAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGC2</accession>
    <name>A0A6P7GGC2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114337781</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144118.1">
        <property type="nucleotide sequence ID" value="XM_028288317.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499644.1">
        <property type="nucleotide sequence ID" value="XM_050643687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGC2"/>
    <dbReference type="FunCoup" id="A0A6P7GGC2">
        <property type="interactions" value="1779"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643687.1">
        <property type="protein sequence ID" value="XP_050499644.1"/>
        <property type="gene ID" value="LOC114337781"/>
    </dbReference>
    <dbReference type="GeneID" id="114337781"/>
    <dbReference type="KEGG" id="dvv:114337781"/>
    <dbReference type="InParanoid" id="A0A6P7GGC2"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028371378" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="21"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="77"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="352"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="686"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028144118.1"/>
        </source>
    </evidence>
    <sequence length="908" mass="104120" checksum="FD76655E54C7C412" modified="2020-12-02" version="1">MAQNLLYISLILFIVLYASAVDKNNFKTCEQSSFCRRLRSVKPGESKYELDLESLEITDNSVESKLLNTEAGILFKFSLTAISGNIFRLQVDEASPLYARYRPQFALRGEPQVAKLKLLERNKEYVSIEYNNNKVIVHARPFKIEVFDKDELISVVNGRGLFKFEHFRKKPEQNNEGEQQQEVAEDPGTWEENFKSHHDSKPKGPSAVGLDISFPGALRVYGLPEHADRLPLRTTGPGGVDPYRLYNLDVFEYELDSTMAIYGAIPVVYAHSPKRTIGAFWLNAAETWVDINNSKDGNVMSSIVNLVSGSKSENNVDVHFMSESGVADLFILLGPTPKAAVKQYASLTGVHPLPQYYTLAYHQCRWNYNDEDDVTTVVQTFDANDMPVDFMWLDIEYTNGKKYFTWDPIKFPHPDIMVNNLTATGRKLIVIIDPHYKRESGYFVHEDCLANDYYVKTKDNNVYEGWCWPGSSSYIDFYKPEAAEYYKNLYRLENFKGTSHDVYIWNDMNEPSVFNGPEITMPKDTIHHGGWEHRDVHNEYALAHTYATFQGLLQRTPNKRPFILTRGHFPGSQRYTVVWTGDNAAEWSHLAVSYPMCLSEALGGMSFCGADVGGFFNNPDTELLQRWYQAAVWLPFFRAHAHIDTRRREPYLFPDDVKNRIRTALRLRYAHIPLFYTLFWQHEISGEPVIRPLFYQYPNDENVVDIDNEILVGDSVLAAMIAEPGASSVGVYLPGGANEYWYDIEDFRLYQGTGNYNIPVSLDKSLAFYRGGSIIPRKDRPRRASPLMKNDPFTLYIALDSNKKASGYLYVDDNESFEYKNQKYLYLHFSFEDNTFNSVLVDKTDYPTKEWVERLVILGPPKGIKGAKLTSKSLGTVELDTSYSHEDRVLVVRKPGVSIREKFTIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GH64</accession>
    <name>A0A6P7GH64_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Periodic tryptophan protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114338088</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144473.1">
        <property type="nucleotide sequence ID" value="XM_028288672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GH64"/>
    <dbReference type="FunCoup" id="A0A6P7GH64">
        <property type="interactions" value="2200"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648368.1">
        <property type="protein sequence ID" value="XP_050504325.1"/>
        <property type="gene ID" value="LOC126883123"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GH64"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="344"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028144473.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50930" checksum="A493168555E10FD5" modified="2020-12-02" version="1">MEYENTQQNINFVPCVRWVKRGVANSSPVKLQLSKNELAQIINDTKIKLQESNENEDEPMEEGETSQTDEFALEDYDKEDENEDTANALGIGSLAELDNDAADNFSESDDSEKEDDKIKPSDNLILVGHVEGDASLLEVYIYNEQEESLYVHHDIMLSSFPLCLEPLNYEPKMPKGNYCAVGSMSPVIEVWDVDIMNVIEPSFTLGRPASKKKNKEHIGHTDAVLSLAWNKTFEHVLASGSVDQTIHLWDMEIKKPSTTIKSFQEKVQCLEWHPLEAQTLLGGGCDKSARVFDGRTPETHQTWLLDGEAERLCWNPLEPFTFLAGTSSGSVQCFDCRKGQLWSVKAHSKEVTGLVLSKQCQGLLITSSTDETVKIWDLATLEAEPKLVNEKEFNMGNIHCLDLCPDLPFVISVGGDKKSNNFTVFDVQNIDVVKHTFGPRGLVQLVPDTEENTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJ12</accession>
    <name>A0A6P7GJ12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114343043</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028149659.1">
        <property type="nucleotide sequence ID" value="XM_028293858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJ12"/>
    <dbReference type="FunCoup" id="A0A6P7GJ12">
        <property type="interactions" value="1823"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644019.1">
        <property type="protein sequence ID" value="XP_050499976.1"/>
        <property type="gene ID" value="LOC126880252"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GJ12"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028149659.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48492" checksum="CBBB0DC2AAE83C8B" modified="2020-12-02" version="1">MTVSVRSTRIATMLAVNTFKQTCVNQAKYLHIYRNLLRKVSFKLSDIGEGIKEVTVKEWYVKEGDKVSQFDNICEVQSDKASVTITSRYDGVISKLYYNVDDTALVGKPLIDVEVEGSEHIEKKSEEESLREIEVSSRSDITANSLCIPSVRRLAKEHSIDLNKVQGTGKNGRILKEDILKFLGGSIDNTELIDQREKVKCESTEGDNIEVIKGFQKSMINTMTEALKIPHFVYGDEIKITEVSKLRNILKNKHDRQISSLPFFVKAISNSLKKYPIVNSSVDKKVENIIYHKAHNIGIAMDTSVGLAVPVIKNVQALSVMEIFLEIQRLIKNGRDGKFSLADISNGTFTLSNIGSIGGTHTKPVILPPQVAIMAIGKSQNLPRFDENNHLVSEEIVTVSVSGDHRIIDGATMARFVVDVKKQLENPYLLFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJU2</accession>
    <name>A0A6P7GJU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114339051</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028289677.1"/>
    </dbReference>
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        <property type="interactions" value="1467"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_028145478.1"/>
        <property type="gene ID" value="LOC114339051"/>
    </dbReference>
    <dbReference type="GeneID" id="114339051"/>
    <dbReference type="KEGG" id="dvv:114339051"/>
    <dbReference type="InParanoid" id="A0A6P7GJU2"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
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    </dbReference>
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        <property type="entry name" value="Mpp10"/>
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    </dbReference>
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        <property type="entry name" value="snoRNP_Mpp10"/>
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    </dbReference>
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        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="187"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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            <dbReference type="ARBA" id="ARBA00022552"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023274"/>
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            <dbReference type="ARBA" id="ARBA00029455"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145478.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028145478.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="68217" checksum="B043248EC639CAE2" modified="2020-12-02" version="1">MPHPADNLNEIVEQFQQLTHKPERFLNSEGDVPDCVKVNIKNFYDFSKSQEKKLNNSKGLPQLLIKGFDIEQIWQEIELQNSSVLQKSLSDLPKYILNRDSLVFSSLVQEEPSYDYDDDGDEIEDDKDSTFIADKDDSGVSDDLSEKEDGNNDEEVDNINGNIYTSKKKSVVDDEFFKLDEMENFLNVEEKKDLPENSNKKPKQMEGEEESDSDDEDSINLFEEEDSDEENDKSRTAKFKDFFRPSNPDVQVKPKRNKFLEEMDIEEENQEVKSSLELRQERLQEKIAQIEENAVSEKPWTLKGEILAENRPQNSLLEEIVEFDLTARPAPVITENTTMQLEDIIRQRIKDKAFDSVVRKEKPIETPLEFKKKLLLDQEKSKHSLAQIYEKEFLDQQAALDPANADKEEEEPRLHRDIKVLMRDLFNKLDALSNFHFTPKPALPEMRVVNNMPAITMEEVAPVTANEASLLAPEEIRNKTKGDILGASEKSKTDKKRERRKKKLKQKHHIKTINKNLISKGKSKGKKTDINVLKHRNTHKMDESSTKSIKSSKAFFNQLQEQAQAHINKKVQGSEKKKNTNKLNARKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLI5</accession>
    <name>A0A6P7GLI5_DIAVI</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114338242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114338242</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
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    </dbReference>
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        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
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        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="51"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506675.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144635.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17891" checksum="5073246C559C9108" modified="2020-12-02" version="1">MAFLVKNSIKNVKWKQLFDISSCQQILRTREMSSEVKKSQSASYDAKKGTIFDKIISKEIPADIIFEDDKCLAFNDVNPQAPVHFLVIPKKQIPRLDDAKATDKELLGHLIYTAKTLAQKKVPNGYRLVINNGKDGCQSVYHLHIHILGGRQMDWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSV1</accession>
    <name>A0A6P7GSV1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor Adf-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114340350</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028291089.1"/>
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        <property type="interactions" value="36"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050641553.1">
        <property type="protein sequence ID" value="XP_050497510.1"/>
        <property type="gene ID" value="LOC126878691"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497510.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028146890.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41564" checksum="327F61B497B7647C" modified="2020-12-02" version="1">MDELLIESVREYPFLYDASEPGYHDSKKKDNAWVQISENFDQWTADDCRKKWIALRDSFRKAYRKRRTTSGQAAKQIRPWKFEKVMSFIIPYIAERHQISNLARDSESSNTSYTDADTEVEVDNLEKDSECEPIEDDGTVENSQQVTDDDMISKLNTSHKVSTVASKKKHSAVKNVAVPLQSPPPVAQVLQEYLQARKNKTETIATERSDALSSFFKAMEQTVRTFSLPLQIEIKGIISNLVTDYELRNYNFQNVTSTSSCSPNRLAASASNISCPAPTPHYRYQQPYPVCSNEYPPSSSLNTQQPSNTPSGSGSEPTPHYRYQQPYPVCSNEYPPPSSLNTQQPSNAPSESGSEQLHGIDKPWNNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GT52</accession>
    <name>A0A6P7GT52_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Viral IAP-associated factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341915</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148523.1">
        <property type="nucleotide sequence ID" value="XM_028292722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GT52"/>
    <dbReference type="FunCoup" id="A0A6P7GT52">
        <property type="interactions" value="1590"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292722.2">
        <property type="protein sequence ID" value="XP_028148523.1"/>
        <property type="gene ID" value="LOC114341915"/>
    </dbReference>
    <dbReference type="GeneID" id="114341915"/>
    <dbReference type="KEGG" id="dvv:114341915"/>
    <dbReference type="CTD" id="39364"/>
    <dbReference type="InParanoid" id="A0A6P7GT52"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148523.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26276" checksum="6B76B123461CA788" modified="2020-12-02" version="1">MQNPNEDTEWNDVLRAKGIIPQKEKEITEDQIVSMLEETIEKKTANGKNLSELDLDELDELEDSEDEAVLLEYRNKRIAELRALSERQKFGFVGEISAQDYINEVNKAGEGIWVILHLYKQGIPLCALINEYMKHLAVKYPTVKFLKSISTTCIPNYPDKNLPTLFVYFEGDLKKQIAGPLEFRGPNLTQDEFEYIVGKTGAIETSIKEDPRPKVKDKMFSDLAETNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GUG5</accession>
    <name>A0A6P7GUG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Glycerol-3-phosphate acyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114343046</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149662.1">
        <property type="nucleotide sequence ID" value="XM_028293861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GUG5"/>
    <dbReference type="FunCoup" id="A0A6P7GUG5">
        <property type="interactions" value="1642"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649853.1">
        <property type="protein sequence ID" value="XP_050505810.1"/>
        <property type="gene ID" value="LOC126884068"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GUG5"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="16">
        <location>
            <begin position="265"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028149662.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="54010" checksum="F10F16CED42A66A0" modified="2020-12-02" version="1">MAMLLMVLSIAGSILLTPFLMLLVCIIFLASIGKSLGVRRLYVKTLLMIFEYGRKDIESSLNHRNKEVPEDIDEGYSEEITQSEKSAEEPPLANGLVNGGNNVISRDEGLIFVPEPPTSKTEEAVKEEKFKDYELSNVFEYVKAGVEAIIEDQVTSRFEAEELKNWNLLIRTNRGYEFISWKLTFLWLGGFFIRYFFLFPLRLIICCFGFLSLIISTFALSACPGGSVRRWLNEKFYKIGFRVMCQCISAEISVHNKQWRPAKGSVCVANHTSPIDVMILSTDNCYALIGQRHGGFLGIFQRALARASPHIWFERSETRDRSAVANRLKEHVSNPKNPPILIFPEGTCINNTSVMQFKKGSFEVGSVIYPVAIKYDPRFGDAFWNSSRFSMVQYLYMMMTSWAIVCDVWYLPPMYQRENESAIDFANRVKSVIAKQGGLVDLVWDGGLKRVKAKKEWKERQQEEFSRRLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GWH8</accession>
    <name>A0A6P7GWH8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-like protein 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114343144</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149753.1">
        <property type="nucleotide sequence ID" value="XM_028293952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GWH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663356.1">
        <property type="protein sequence ID" value="XP_050519313.1"/>
        <property type="gene ID" value="LOC126893315"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GWH8"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000375">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000043">
        <property type="entry name" value="AGAP008687-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028149753.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="45865" checksum="5C0FBAAB940F3A75" modified="2020-12-02" version="1">MSGAVYGGDEVGALVFDIGHNTVRAGYAGEDSPKVDIPSTIGVWLDSDEDIPVTRYNIGLLAIHVWRPGMELSSFLKEGMVENWDMFENFLDYIYNQALRAIPKDHPILLTEPPWITPVKREEMAELMFEKYGVPALYLAKNASLAAFANGRPTCLVVDSGATHTSAVPVHDGYVLTQAVVKSPVGGDYLSAQSRSHLTDRGIEIVPPSFVAGKEVVKPEEAPIWKKRMVPLHLTESWYNYMIKEVMQDFQATVLQVSDVSYDEEIVKTMPANHYEFPNGYHRDFGVERFKIPEPLFNPTTGAKAGIQPILGVGSLVTTSVGMCDIDIRPAMYGSVVVTGGNSSLQGFTERLNRDLAAKTPPSMRLKIISAPGASERRFGAWTGGSILSSLGSFQQLWVSKQEYDESGKIIVQSKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GXZ4</accession>
    <name>A0A6P7GXZ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114343656</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150293.1">
        <property type="nucleotide sequence ID" value="XM_028294492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GXZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294492.1">
        <property type="protein sequence ID" value="XP_028150293.1"/>
        <property type="gene ID" value="LOC114343656"/>
    </dbReference>
    <dbReference type="GeneID" id="114343656"/>
    <dbReference type="KEGG" id="dvv:114343656"/>
    <dbReference type="InParanoid" id="A0A6P7GXZ4"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="416"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028150293.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="65142" checksum="2170292DCB0DD611" modified="2020-12-02" version="1">MPHICILHKNSTLSDYVGVPKSRLQLGLRRLFIVSEDNVYSSVYFRSEKEIKSEKIRQLESGYSFIIHPLSKFRMYYEFWLVFLYAAVITVKALDAGIRDGAAGSCPVPENFKYQDQDHFFKIYAYISTSIDVISWSDILINFVTGYEVTKIRIIELRPTKIAIRYIFRSFFLIDLLGAIPRFTLRCLMDKPPLVALGIQNIFSLLKGIRFFSLLRILIRVLRHLGVKSRSWIYGTCYFAIFIFILHYSTMLMLGLPRIIRVYLGTGNCTLTVKREQIPLHVQYNDYMFETSAYFLQVALPKSYYRDLYFEEVILAIFFCMVGKIVMTVMWVALAASILNSQSSRTRYQALIVQVEEFMKQRNLPLELRQRILQNFSFKYQGNYFREDTLTFLLSDRLKKEVKLHLYSTITEKVGIFKILDVDALNDVLKVLKPEIVLQRDVICQSGAHGDCMYFIASGTVAVYTSNRQEMCHLVDGDYFGEICLMTKYNVRPLTVSAVETCQVYKLYQDDFENTLAKNKKVIKKMLSRMEKMVKKAEYLEKIYRKSIFEATYGYNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HDJ4</accession>
    <name>A0A6P7HDJ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LIM domain kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114347312</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028153835.1">
        <property type="nucleotide sequence ID" value="XM_028298034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HDJ4"/>
    <dbReference type="FunCoup" id="A0A6P7HDJ4">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298034.2">
        <property type="protein sequence ID" value="XP_028153835.1"/>
        <property type="gene ID" value="LOC114347312"/>
    </dbReference>
    <dbReference type="GeneID" id="114347312"/>
    <dbReference type="KEGG" id="dvv:114347312"/>
    <dbReference type="CTD" id="3984"/>
    <dbReference type="InParanoid" id="A0A6P7HDJ4"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09364">
        <property type="entry name" value="LIM1_LIMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09365">
        <property type="entry name" value="LIM2_LIMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000082">
        <property type="entry name" value="LIM domain kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000197">
        <property type="entry name" value="LIM domain kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF4">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 16" id="KW-0440">LIM domain</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="20">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="20">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="21">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="426"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="983"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028153835.1"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131397" checksum="D4E8C76D2696BF27" modified="2020-12-02" version="1">MQDQCENEKEDGSAPPSEIICAGCLNAVDDEEFVSALGQEWHMECFRCSACDASLSNWYFEKDGLLFCKDDYWARYGESCQQCSQIITGPVMVAGEHKFHPECFCCGSCSAFIGDGDSYALVERSKLYCGQCYKRQMQPLQKTAGFPFARKPHSIRLVEIPGGQKGIKLSKNALHPDCNTQCFTISEFLWKIHGKLLQVAFAFLTSAFNICCYFLPPYRLDVNNDLMSLHIGDKILEINGMPVKDTSLENVENLLRYSDTVLQLTIEHDPETISRNLAKFTALRHSNIPLTTTASDTNIPSIKSVPDNVICSGSTDSLNGDHKSDFFNIPTIQQPCETFDKPNNVGINKERLFKRKDEGYMSGTRSRQLRRKNNLSDNQCLDKERSSSLSRLLDESPNSKRCLELSRAYSFLEPRPQQRVFRASDLVKGELLGQGFFGQVYKVTTRDTEEVMVLKELYRVDEEAQKNFLKEVAVLRSLNHNNVLRFIGVLYKEKRLHLVTEYISGGTLTELLHDSCQPLPWEQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRDDKTVIVADFGLARIISHATNSTRKVSPKNPTGCKRQERKKRYTVVGNPYWMAPEMMKGNKYDEKVDIFSFGIILCEIIGRIQADPDFMPRSNDFGLNQMAFKEKFCSSCPEPFYKIAFLSTDINPDKRPPFEVMEVWLESLSMHLSVGMALPPDLLFDIQHYRGLSPSSSGSTTPEGIPSGHRSPALEPICEGKMANTKRSSEKIFSDCKGVDKSRSSERICGEGRLVDGTSKSKSSEKIYKSSENLKPIIKVSSAENIKPVIKVSSCEGLAEKSRDTVDFLSKPPESLILSDLEKDFPNYENIDFLKNDVAYLGDQEKHIGIQKLESEPIKCDKSISSTTDNNLRENVSPHLRKIPKNFTRNRLVKEMKENQAREDKIMLKSFDADHNTKVTNLNLNSIGLKTSQPSQVTEKFVSNLKNVNLKENPTYQRSISETSESPERRHEFRSSLSRRRYTKDPENSNFLKRTPILKRRSPTKADNVVPDSIASPERITSLEKTSLDLDCKDKSLNVLEKPSLLSKLTPSLQRRTGFLNLEDSSGNVSKKPFLVAASSGSIVRNMVDSLNRKGGLGFGNRTSFGRCSLNLSGSSKVNLKKVGRSPSPPEEYTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I959</accession>
    <name>A0ABM5I959_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028127783.2">
        <property type="nucleotide sequence ID" value="XM_028271982.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271982.2">
        <property type="protein sequence ID" value="XP_028127783.2"/>
        <property type="gene ID" value="LOC114324214"/>
    </dbReference>
    <dbReference type="GeneID" id="114324214"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127783.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="178" mass="20927" checksum="9D03119A2C1D2140" modified="2025-10-08" version="1">MVRAWYMDNDSASDKNLPHQKIPGEYININDLNSSLGVKYYKINIATIDTDGVLDKIKEQNGCHYEDEITTEKCLQNNGEMSKIFYTEHLHKDDEIRLCVEGSAYFDVRDRSEEWVRIEIVPGDLLILPSGIYHRFTLDTQNHIRLRRFFISDANWSSFNRPSDNMDCRKNYVQKLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5III1</accession>
    <name>A0ABM5III1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133594.2">
        <property type="nucleotide sequence ID" value="XM_028277793.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277793.2">
        <property type="protein sequence ID" value="XP_028133594.2"/>
        <property type="gene ID" value="LOC114328841"/>
    </dbReference>
    <dbReference type="GeneID" id="114328841"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133594.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="392" mass="45116" checksum="22151BE9DA9F9E62" modified="2025-10-08" version="1">MNHRIELAVSDSINDVGAINHFQMFMDKLYTLYSKSPKNQRELAECASELDLQLQKVGRILGTRWVSSSFKTVMAVWYGYQALYSHFKKAQEDKNRTTTERAMYGGLIRRLTSTQFLSDLAIMYDILAELTMVSECLQNREATVVYADKLIRRSIAFFECLKEKPGTKTLEAKRAAITGNFCHVPLTSSNKITAINDQQLLSSVINNLKRRLFTTRSSNEPSNKATGNNYDYEKEYESLLSELKVLESNNWPPEKYVGYGEQEIEHLCARFRLNANKIKNSFRDYLENSTTIPKDLNPLINCTKLIPCSSAECERGFSHMNIIISPTRSKLTIEHVSALMFIKLNGPSIQTWKPENYVKAWLRRHRTADDTRTRRANLQPDKEEEDAFAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMR3</accession>
    <name>A0ABM5IMR3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136650.2">
        <property type="nucleotide sequence ID" value="XM_028280849.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280849.2">
        <property type="protein sequence ID" value="XP_028136650.2"/>
        <property type="gene ID" value="LOC114331319"/>
    </dbReference>
    <dbReference type="GeneID" id="114331319"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046058948" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="117"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136650.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="18693" checksum="99533E6F5F07889B" modified="2025-10-08" version="1">MNKVPVLRIFISAVIFLIFGTNECESQCTQQGSFPSENGNCLSYYTCVVRNGQWVRSNHTCPIGRPFNSSVAICDFTATCSTTTDSSTTDSTTAETTEATTIETTAATTTATATTKTAQCPPLGIYSLNSADCRSYYRCSYYNGKYLLNNYRCPVGRPFNSATQICDSSLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INP4</accession>
    <name>A0ABM5INP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease 1</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028137522.2">
        <property type="nucleotide sequence ID" value="XM_028281721.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281721.2">
        <property type="protein sequence ID" value="XP_028137522.2"/>
        <property type="gene ID" value="LOC114332022"/>
    </dbReference>
    <dbReference type="GeneID" id="114332022"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="9">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137522.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="351" mass="39866" checksum="E2CD5D6284932DF6" modified="2025-10-08" version="1">MGIRGLLSYLKSAERECHINEFKQKTIAVDSFSWLFKGADLMNPAKDDGPNSLVNYCLNNVNLLLNHDIKPIMVFDGKYLPVKKEIKELQTERMQPREKRTHIGGFKRSIRKCNTNFHPAAIRILISECQKMKVDCIVAPYEADAQIGYLTKLGVIDAVIAEDSDLVLFGCQNIIYKLDDEGQGVLLERDKIPQDELSFDQLIYTCILAGCNYSTPLAGMSLNKAESLVKLSEEKDPIKILEELPKDLNVTDQYKDEFMGALAVYKHQVVFDPFEKKLVHLTEPDLKEPLEKYCSKVGTFFDDSEAYQIAIGNLNPINNIKRNYWDPKNSAPHSIWSSQRRNQDDPKEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IS64</accession>
    <name>A0ABM5IS64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140349.2">
        <property type="nucleotide sequence ID" value="XM_028284548.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284548.2">
        <property type="protein sequence ID" value="XP_028140349.2"/>
        <property type="gene ID" value="LOC114334502"/>
    </dbReference>
    <dbReference type="GeneID" id="114334502"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0401">Integrin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045627032" description="Integrin beta" evidence="11">
        <location>
            <begin position="24"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="12">
        <location>
            <begin position="43"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="491" mass="55860" checksum="E7532FF0F3E60AE4" modified="2025-10-08" version="1">MRFEKHLFTVFLVFSCIKVSVLQNDLKCDDINTQKLCVDQDLCDSCLESHICCNYCYDKSYTGRRCNTKNQLLKSSCNETMIEFNQKSRVITQKDKPFTTKGEIVQIKPQNVLVQLKKGVPTNVSFTYKLAENYPLDLYYLGDLSMSMKPSMKIFASLGQHLPGNLTKLTKHYKLAFGSFGDKPAMPFYYTDEESTRNPCSKVMDTCAPGYSFRHHLNFTAKTEDFLDVVSSSKVTANVDDLDGALDALLQVLACNETINFSPLSRKIILLPTDSLLHSAGDGILAGAVRKPDLKCLLDQNGEYTKSLINDYPALDQIEFALRKNKVNIIFAVKTLSKMHYYLNMTRDTLKGYAFVGELQEDATNIVDLITKGYYNFAQTVSFMMNTTEQEYIDVKFFADCSNLGIYNETSICYGLDNREVNFKVQLTAKHIPEHTQRDTLYVEEKNINEKLTVNVEYVSSCQCSNYKDDGNKFCGHGTYRCGRCYCQEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXL0</accession>
    <name>A0ABM5IXL0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147305.2">
        <property type="nucleotide sequence ID" value="XM_028291504.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291504.2">
        <property type="protein sequence ID" value="XP_028147305.2"/>
        <property type="gene ID" value="LOC114340736"/>
    </dbReference>
    <dbReference type="GeneID" id="114340736"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21190:SF1">
        <property type="entry name" value="GH10077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="888"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147305.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117591" checksum="2DAA34A524459265" modified="2025-10-08" version="1">MTSVTLPSGSGTLNGGYSSSMTEKLPSNKPDFDALRTIKRSLSLTSTDSCKKRRKQSTPIRISTSEKDSPTASPIEGKSVPSPEPTHRCLLCQRCFSYPEQLQNHICENPSLECKKEPDDHPTTPSSVSYLDQPDTPLGLSMMRSDMQWVNDMQNKEWIGSSLPNISFNAANPMFMALPQYSHSDNISLKPIRIFNPDAYCDLCNKEFCNKYFLKTHKANKHGIYTDSSSSEPLPASVNIPPLSTNLKLPNLVPTADQSTATNEPKTPVNMINPFNSIFQNPFLSTNQTTLTESEINENVAMSNGMSSSSDSDKFFSEDHRAEENTSPCIQTESTSIKNDPDGFFQDTSSKLSSDQTNRESDLSYRLRKIGVMNPKAFCEICCKEYCNKYFLRTHKLKRHGIYIPEDKEKDIRGECMSGFSSSTNVQTSPLNLIMTEQGSSDSKITSPTSIGCDLCCIKFQNASLAHLHNISVHGRVCSRESEESDRPSQQDVKPSEGSKSSEKSINPEAISEDLQKLQTMILQLNDINITKVSSNCTICNKEFENRFFLQSHMISEHSLLLDEGECEKSGDQETSSNNNTICDICGKDLPNFEELSRHIMEFHSNNSMVGDVAKEDSNVANSGEKLSSRVSISGGHIPERRISMNVTPTSSYCEICNKELCNKYFMKTHMQRMHGIEIENGAQIGGVVCDICNKELCSKYFLRVHKHNTHGIIEYGGNLLPPRKSDGEPSVLPSPSLPLEADPALKPGDLADMSHRYFSHFTEVCTICNRRFRSTKWLKAHLITDHGQVGAEKWAEIEHQLQQNRGITSKPVMSSSAEGNPSLKVPNGSQDLQQKVGGVQNFISSLFGIDESNSKMYQCSYCSFTSPLLPLLFVHERSHMNSEGFSLKCPVCPQNFVDRKLLQRHLLSSHAFLLPTTNREEETKEIYTSKENFEDDSLSKQEQGISTSSQGKCKQPPSPIKSKPIELSSEIEQSLKDVAKRMQWPATYAIPQNQLEHDHQDEASLSSGPGYVMQAFLLEESTSERRVMPSVVVLPMLQKQPAPLTVTFTLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZA7</accession>
    <name>A0ABM5IZA7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151667.2">
        <property type="nucleotide sequence ID" value="XM_028295866.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295866.2">
        <property type="protein sequence ID" value="XP_028151667.2"/>
        <property type="gene ID" value="LOC114345034"/>
    </dbReference>
    <dbReference type="GeneID" id="114345034"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046889561" description="DOMON domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="6">
        <location>
            <begin position="156"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151667.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="818" mass="94010" checksum="D325B781F355B56C" modified="2025-10-08" version="1">MTPKWSDLLIFLIFILQITTNATEDLLDQYVKHVESVNSINYNLDKRYNKKYHHPKSRRKLHGFNDIDEYFKESQEDTVFFDLLDSFPKENSGSQKPENDRHLLRKRSVVDSGSESPEVEDFDLLPDIDEESKHREKRDASSDIAWTHSETLDREGRIILRWQPRHQEILFRVEAKTRGYIGLGFSSDGKMEKADIILGWVDDKTGVAVLMDCHGVPTSQGSAPVRDEIDNYTLMRGLQNDTHTVIEFRRAFDTCDPDDYVLSGDTVRIIWALHEYDPQRGAEMVYHGENRGHQSVHLLGPPPVAKMSIGHSSHWDVVFDDFKITEEVSTMYWCKVFKAPTLNSKHHIVGFEPIIGDKHSNLVHHMVMHECELDVNEDVAIWEQFSKEKGKPCYSNTASLWDKCLTPLVAWAIGSKGENFPNHVGVPLAEKKHSFYMLEVHFDNPKKKSGLDTSGLRLHYTSELRENEAGILITGVAPSTLHFIPPYQKDYKTAGYCSIDCTKEVIPKEGINVVSVMLHSHLAAKKLKLRHIRAMKELTPLAEDNRYDFNYQQSRSLSQDIPILPGDGLITECTYSTLNRSKPTLGGYSTQDEMCLAFVLHYPRTQLAGCYSMPPVKYFFENLGIKEFYGKDMNQIEKALLEGRIDGEPATSTLNPFITKPGDELSSEANHLAIVALKNAKDYVIEGYQDEWHAVFDKLVIKEPQEFRNLTFTEHLHNMPYNETIFTKTMEKYFYEGLHLTFCRKRDDTLAINELIVKLPEFQQYERRENIQCSYRSKTSYTSQENGAFSSSVKVWMMTRATLTYYSLLVSLLITGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIR1</accession>
    <name>A0ABM5JIR1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497826.1">
        <property type="nucleotide sequence ID" value="XM_050641869.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641869.1">
        <property type="protein sequence ID" value="XP_050497826.1"/>
        <property type="gene ID" value="LOC126878990"/>
    </dbReference>
    <dbReference type="GeneID" id="126878990"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52366" checksum="2E9E9B1BF71F72CE" modified="2025-10-08" version="1">MASFKAEHLSTPELDYELKIRQLADPSLTTDRAKVIVLTGALKQASANRSHAVLSAFQLNFSDEVREIEATLADLKTQISSFVGSHSDVLYGRLTSRLGHVSGRVHLLESVTEEEDAIKKSLNFKILNLEGELEFKVTPQAHSTPHNPSVSVNSFPFFKSAPIHKWGVHFSGGSNENVVSFLEKIECLRLARGNSEDECFSSAGDLFKDSAFTWYLNNRGSFTSWQELVAKLKSDFLPYNYEDNLLDEIKSRKQAPQEKVTIFINEVVSLCKRLEVPLSESHIVRIIKKNLLPSYHPSLALTDILSIADLTEKCKRLEEVLSWSSEPISSVPSRSSVRNNESSYSGRPNYSRSGNVSTFNSRITCWNCRQPGHGYFDCSEPRGLFCYGCGHQGVRKFECEFCSGNDRRGGSSPLALTPHQNTGNTLENPQNPGSSFSSQEAHASTTQTSQPPPKDKRPRNGRYQPKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJR8</accession>
    <name>A0ABM5JJR8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498186.1">
        <property type="nucleotide sequence ID" value="XM_050642229.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642229.1">
        <property type="protein sequence ID" value="XP_050498186.1"/>
        <property type="gene ID" value="LOC126879184"/>
    </dbReference>
    <dbReference type="GeneID" id="126879184"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="518" mass="59087" checksum="8B89B2C2F0CFEB85" modified="2025-10-08" version="1">MFGQSRGKYLMNLAIQKKRTKDDLENCEATVASGPSQAQDGPMEVVNEGHSERATLENLGPLELLGMDENNIILLENVSDQEAGLFFSQPLEIQITGDQPPTLNENVETLQYQELEVPVHEISSVISSNSNFNSDSDEQYQPPSSNSTASIESDDSQPPSNNSTASIESDDSIRVASVLQAENNEQSATEETASKRKKRRGKRNGNEYKRQKNAEMRLFGKSYVGFKKDASGKYKQIKQIDEKKIGPRCRGHTRMKKGGPRQSFFCDQINDEERSRLFSEFWALPNWDSKKTYIKNNVLHSEPKYKRNDSIDVSRKKTTFRFYFSMSDGNRGKVKKQVCKQMFMHTISIGERPLRDWVKPPETSSSQASTSVENISASENAIIELKEWLNSLAKVESHYCRASSDKLYLEPVWGSMRDFYRKYVSIFKGLGKTKVSRTTLKKIMDNMNLAFYTPKKDQCNECTMHGAGTLDKESYAKHIKKNKKQLLKKRLTKAKPLKIVAKSDLIQLTYKLCFWHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMI1</accession>
    <name>A0ABM5JMI1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid synthase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
            <ecNumber evidence="2">1.3.1.39</ecNumber>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
            <ecNumber evidence="4">2.3.1.85</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="68 69">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="68" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="62">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="62">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="55">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="58">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="58">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="59">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="59">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="60">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="60">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="51">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="61">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="61">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="63">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="63">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EC" id="1.3.1.39" evidence="2"/>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EC" id="2.3.1.85" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050499146.1">
        <property type="nucleotide sequence ID" value="XM_050643189.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643189.1">
        <property type="protein sequence ID" value="XP_050499146.1"/>
        <property type="gene ID" value="LOC114327245"/>
    </dbReference>
    <dbReference type="GeneID" id="114327245"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="Polyketide synthase dehydratase"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Acyl_transferase_dom"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
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        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="KR_dom"/>
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    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PKS_assoc"/>
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    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
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        <property type="entry name" value="PKS_DH_N"/>
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        <property type="entry name" value="PKS_KR"/>
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        <property type="entry name" value="PKS_mFAS_DH"/>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="Thioesterase"/>
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    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="FATTY ACID SYNTHASE"/>
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        <property type="entry name" value="ADH_zinc_N_2"/>
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        <property type="entry name" value="KAsynt_C_assoc"/>
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        <property type="entry name" value="ketoacyl-synt"/>
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    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
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        <property type="entry name" value="PKS_DH_N"/>
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        <property type="entry name" value="PP-binding"/>
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        <property type="entry name" value="Thioesterase"/>
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        <property type="entry name" value="PKS_AT"/>
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        <property type="entry name" value="PKS_ER"/>
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        <property type="entry name" value="PKS_KR"/>
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        <property type="entry name" value="PKS_KS"/>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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        <property type="entry name" value="FabD/lysophospholipase-like"/>
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        <property type="entry name" value="KS3_2"/>
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        <property type="entry name" value="PKS_MFAS_DH"/>
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    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
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    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="69" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
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            <begin position="841"/>
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            <begin position="1952"/>
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            <begin position="841"/>
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    <feature type="region of interest" description="C-terminal hotdog fold" evidence="64">
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            <begin position="978"/>
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        <location>
            <position position="875"/>
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    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="64">
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            <position position="1027"/>
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        </source>
    </evidence>
    <sequence length="2312" mass="258462" checksum="3BE78B2DC2CBC38E" modified="2025-10-08" version="1">MKDHAENDRIVITGISGKFPQCANVEEFKEALFGGVDLVKEDSQRYPAGIMGVPKRSGVLLEIDKFDASFFGIHPKQTDFTDPRHRILLETVYESIIDAGYNPAELRGSKTGVYVAIGSFNCYEEFHKEKSTGGYTIIGANLSVAANRVSYCFDFKGPSFALDAACSSSTYAFVCAIKDMLLGETDSAIVCGTQLFQHPFETAEFMRLNMLSPEGKCKVFSTNRDGYVRAETVVSYFLQRESKSRRVYATVLAAKSATDGFKEEGITYPSIEEQFILMRNLYDSINVDPDTIQYVEAHGTGTPVGDIIECESLRKHFCQKRNEPLLIGSVKSNMGHSEVASGLCSLTKAVITMEEGMIPANIHAESLDSSLPGLKENQLKVVTKNTKFNGGIIGVNCFGFGGANTHIVIDSNKKEKSAIVYKRPKNRLVQFSGRTEEAVLHFLDGVEKNQDDPEFLAMVDEIHKLNIKGHTYRGYTVLGEHQIKEIGKYNKKRPIWFVYTGMGSHWNKMGRDLLNIPIFKNTITRCARVLEPYGIDLINVITSEDPRVFDNITNIFCGIGSIEIALTDLLHSLNIYPDGICGHSLGEVGCGYADGQVSVEQATLLCYARGYASSNSTIIPGQMAAIGLSKGEVSKMLPQDIFVACQNAKESVTIAGPREETKAFVEQLSAKGIFAKLVNSGGIPYHTKYVKEAGDLFLDFCKLVLPDPKPRSEKWVSSSVPESKKHEKWAQLNCAEYHHNNFCNPVLFDQVYNHIPKNAIVIEVSPHGLLQAILKREMGPEATQISITNRSSGDNEKFFLSALGKFYLAGGQPNLRKLYNEVTFPVSRGTKMLSSLVKWDHSVSWFSKRYEHKNSCGISVNVSLSDEEFAYLEGHQIDGRILMPATGYIDLIWNVIAEFNLKNKEELPIIMENIKFKRATIVTDGEGVTFNITVMKQSGYFEIFESGAVVCTGYVRVPKDVSSEFKEKDGLKVSNSQEITLEEHDIYQECQLRRYMYKNYFRGLTECDLSGRNGRVQWKGKFGSFFDTMLHITIIGMCSRDSLLPTSIRQITVDPIKHMEMVDKNKEELPITYNTCQNIIKSGGVEIIGTEYSKAPRRQHTQEPPYCETYSLVNYSETAAEYDLETAMSTAMQIILQNNTGTVKQVKICEIMPTQGNREIDPIVKNIMAKQVLSKIEYFSSRLENLKDKFQAIIINDKEVQLEELNKLVNNLTENGFILFKGSFEHTRHSSLEIIFESVLDNDKVYLLKPTTEVSKNYAVLNISNTNLDWLENLKNLGKINEEKTVYLVSQNEDFSGIIGLTKCLLTETTKLRFRAFFIDQHGSKFSVNDPFYKNQIKKDLTFNVLSNNKWGTYVHLPLRDLNKQTVGNAAVDISTLGDLSTIEWTEMAFEGRRVTEESEMVYVYYSALNFRDVMVALGKVPIDSNDNVPTKSSGMGLEFSGISASGKRIMGFVNGDALALQVQYDPYFTWEIPNDWSLREACTIPCVYATCYYGLIMRGQMQPGESILIHAGTGGIGLAAINIALSMDCEVYTTVSTKEKKDFLKSIFPSIKDENIGNSRDLSFEIMIKNNTNGRGVDLVLNSLADTMFQASMRCVAPGGRFIEIGKVDLMNSSPIPSSMFLKNICFHGVHLDKLFSFDDRAQRQIQQLVAKGIADGVVKPLPNVLFEENEVESAFRFLASGKHKGKVLIEIRKEELYSASKPIRSILATPKVCLDSQQSYIVTGGLGGLGLELAGWLIQKGATRIVLNSRRDLLNGKQAYHFRKWSNYKNITVKVDTSDTSTEEGADSLIRFAQQLGPVGGIFNSALVLKDQFFLYQTKENFYEVFKPKILSAQNIDKCSRKLCPDLNYFVVFSSISTGRGNIGQINYGMANSAMEMLCEKRRRENLPAVAIQWGPIGEVGILQKMGIEERVFHDILPQNLDSCLNTLERFMVDEYVIGSSVVISERDDQMGKQKTKTPVEAVAHILGIKNLDTIDKSLTLSQLGLDSLMVTEIKQTLYRNFNIDLSPEEIRELTLNSLVASDSTKNEDISFGVQVEANTYLISDDPLIKLRDSKSSNTNIFVIHPIEGHVNVLRPLGSRLNATVYGLQCTSDTEMNTMNDFGKYFVKKIKEVQPKGPYHLCGYSYGCALGTEIGIQLESAGDQVDVVYIDGSPSMVHEVLKVTHITKGNSVENSKEAILENFCMTFPQVEQKEIKACLSNEKSLDKKLQSASELISKVTGIDQLKVLTSANSLIQRIEAGFFYKPSKKLSGSTLLIRRNDNPFSTENYDLNQVCNQAPYIEKIDGDHKTILLGNNTQKVADIINKFCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQH8</accession>
    <name>A0ABM5JQH8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-binding factor A, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500194.1">
        <property type="nucleotide sequence ID" value="XM_050644237.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644237.1">
        <property type="protein sequence ID" value="XP_050500194.1"/>
        <property type="gene ID" value="LOC126880399"/>
    </dbReference>
    <dbReference type="GeneID" id="126880399"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039212">
        <property type="entry name" value="RBFA_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14725:SF0">
        <property type="entry name" value="RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="Ribosome-binding factor A, RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41584" checksum="9A36A51EEAC36025" modified="2025-10-08" version="1">MSRNFLVLKSVCLHFNSNFHTSCCYQVAPRQAGNFMKKVMGAIKKKKAYFKEEAPNITDAFSKPSTGHISTNPRRVTVLNKLFMRNITDLMSTELYSSQLLGLGVEINKVKISTDYKILKVYWTSANIHQETAEEILLKNAGLLRHALSQLRLMGNVPIIQFVKDKHYDKIHELNKRLAIADYGEDGPSNTDPVAHLISEFQLSMPIDDKLKEQLVKLEEQNPYEVKDLQLPAMTHCVFNLDHEDIMNRVKKNNRKTRNADSSSRSVDESWASFKLNQYSNTDPVVLGNAKLQREAFNKFLHQRNIMQKKLKESRYADADTDFIREDIKFNNRYLEPNDVDDDYIIEDTEDRKLNDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS37</accession>
    <name>A0ABM5JS37_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500754.1">
        <property type="nucleotide sequence ID" value="XM_050644797.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644797.1">
        <property type="protein sequence ID" value="XP_050500754.1"/>
        <property type="gene ID" value="LOC126880749"/>
    </dbReference>
    <dbReference type="GeneID" id="126880749"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="79044" checksum="E8AB6631A9719014" modified="2025-10-08" version="1">MAEQELKSLKARRGVVKGKLTRFKNYFDKIDKDDISKKLITDVEFRLSKVTPLYEEFHEIQEKIDELEVSKDNENEINTFEASYFELVCDMQTFCDNFKIEYNADIVSVHSDSNQEVNNNSFQALVKLPPISLCTFNGHYDSWLEYKDCFLALVHNNASLTDIQRFYYLRSSLEAGPQQIIKSIEVSSINYKIAWQMLTERYENKKLIIHNHLKAIFDHPAINNEYHLELRDLFDNVTKHLRSLNSLGLDTQSWDSIIIFIMCSKFDATTRREWEGFKHKNDSPSMTDLNIFLKEKCQMLEKLQISSGYKNNKARVRNVNSRSFASIERQSSVKCYFCQNDHPIYKCDAFLKLNINDRISAAKRLNLCLNCLRNSHPTWKCKLQKCIKCHKLHNSLLHLNNPNANVPRNMVTTDINDPNQHRTGSNPNIDIIDNCIERSDNDQRQLSSSLHISKDVANSYEISEVLLSTVLVRIVNGNKSIVCRGLLDSGSQSSFISEKICKLLDLKCQKVEHLVKGVGEALAKINKKAIVTISSCQGDFIMDTHCLVIPNITGKLPIRSFNKNDLKIPLGLKLADPDFHVSDDIDLLLGSSIFWSVLLGGKKSLGPNMPILQNTKFGWIIAGNLYLNSLEPKNSHTFFNVNSYNESINNQLVKFWEIEELGSSRKILSNEEMFCENYFKETVRKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS82</accession>
    <name>A0ABM5JS82_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500790.1">
        <property type="nucleotide sequence ID" value="XM_050644833.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644833.1">
        <property type="protein sequence ID" value="XP_050500790.1"/>
        <property type="gene ID" value="LOC126880778"/>
    </dbReference>
    <dbReference type="GeneID" id="126880778"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19438" checksum="00D5D0F696291201" modified="2025-10-08" version="1">MGAINNDISLKDLLEAGPSHVPSPVCEKSLEEIRPLAKAGERTSKTGGRKRRTTAMLTDTPIKDELELEKQQRKKKKTKQSKAGLKNVKRDICSKKTKAKEIDSSSEEDECFYLICLELFSNSVSKEKWVQCTKYKEWAHEACTAGDILFLCAIAVCPMRISDCIFLQIYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSW4</accession>
    <name>A0ABM5JSW4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501020.1">
        <property type="nucleotide sequence ID" value="XM_050645063.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645063.1">
        <property type="protein sequence ID" value="XP_050501020.1"/>
        <property type="gene ID" value="LOC126880981"/>
    </dbReference>
    <dbReference type="GeneID" id="126880981"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65169" checksum="5DD1533846D50105" modified="2025-10-08" version="1">MCPDLHEKENKNRDLQKSESLENTLTTVASETLLQTINVRVISDNKRSMTVRALLDSGSQRSYITTKCAEDLGLTKIGQENIVQGVFGGLQGAPKIHRLFKAGIENLQNSFSIGLSLLEQSKICNYVPKLIDQKVLDLLKDKNIYINDSASKELEVNLLIGADMFGHIITGNLVNINDSLVALETKFGWTVMGTQKSNNKINTFVSTYFTDSLSTLWSLDVLGIKDPAETKCREELDIRTLEKFKESTVVNSENIYEVCLPWAEGYPAITSNFNLAEKRLFSTTKRLLSLNKLTEYDNIFQDWENTGIIEEVEEEPLEKNTHYLAHHAVVKESSLTTKIRPVFDASAKDGNGNSLNDLLEKGPNLIELIIPLILKFKLHKIGVTSDIAKAFLQISISEKDRDFLRFLWWKNYEKREIKIFRHCRVVFGLKPSPFLLAATVNLHLEMEKTYTETANQLLNAFYVDNCVSSVRNETELKKFIDESTEILKNAKFDLRGWTFNENNDTYVSSVNEKLENKVISILGIQWNYQTDTLACDIKNLDSLDEIPRTKEAFYLQRREFLILLVSLLHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUW6</accession>
    <name>A0ABM5JUW6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501733.1">
        <property type="nucleotide sequence ID" value="XM_050645776.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645776.1">
        <property type="protein sequence ID" value="XP_050501733.1"/>
        <property type="gene ID" value="LOC126881490"/>
    </dbReference>
    <dbReference type="GeneID" id="126881490"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="659"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="766" mass="84218" checksum="D65E818B4B61656B" modified="2025-10-08" version="1">MELVKHILVYNKNSEIVLGPKFATVNKNSCLLGFKGNLPVLSSETFINEVINKPMKIKVELGTSSEKFIMFNGKKLMILADLPEGLLKMPPASNTPHNSNLGKPLSIEHKLSNNLINNTSTPSTSSNSIPKMITVNAPESPSIGKHLLADSKLPKVIKIGAAETQNIGKKLLKTDPKLAGVLLQRNTVCTTSNNSMPKLIKINALQTSNIEHSTTDSKLSKDLVKTISISGKGNSILRKIKLSPSDVTSVDTNILTDSKLSRSLLKNSTSNSSVPKMIKVSKPLLKPVGEDCKQSPKIMNLSIKVDKDVMSQISNKPPINENKLIKINVASITGSSKADTTDNNIICAADKIKMFAKPITVRNKVMCIPINQDSVESVALDLTKHCESQTVKTPAKMFRDQGTQVDIDIKPPKPETVSIETNTDITGDIVKKEENWFNLLDFSSLDNDIPQSPFPEGLLNSLENFDLPGKSMDNSKEYTTLTNAVTGKNVANYSDNSVNTAKNLFMELRQALVNNDEGNLPIHVGVIANNFKLVKRNLFLLKVLKHSVDVPNSHDYTPLQLALIHNSSIEIIEALLAEGASCRTTDSEGNSILHYGAELNRKEALKLLVSFAGLQRCTLNPFNHEGLTPLMVCCLNKNFECAEILLDADADPNIKDQISGRTALFHAAEKHDVEMVEMLLQFNANTKLKNFFGTSPHDAMYELDGMPEAIKYMILGKNNKRKSLDDNPKVSKHSRPNNGVQPTLKTYSRSQQIRGNHVSKTYTTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUZ5</accession>
    <name>A0ABM5JUZ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501760.1">
        <property type="nucleotide sequence ID" value="XM_050645803.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645803.1">
        <property type="protein sequence ID" value="XP_050501760.1"/>
        <property type="gene ID" value="LOC126881510"/>
    </dbReference>
    <dbReference type="GeneID" id="126881510"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="829" mass="96726" checksum="05ADC93C35469A51" modified="2025-10-08" version="1">MNRCTKCNINFTKYYNMRAHAKRKHPDMLDILLPNNVQQSKSTVPCLECNKKFSNLGNLRLHVKRQHPDKLDEIAPVNKKTYVCSSCSESFHNLKKLVSHKQTHNNALTKLKCALCQYNNSGRENLILHYRSDHFINIENNYLEFDTFEDFESWKCKVEEETFSSFVKMYGSKKTSNCTTTNYSCHRSGIYKKKGMNIRKLKIQGSNKINGYCPARINVKLMDNEKYIVNFCQTHVGHSPEQDLGHLFLSKSDKQNVAAKIAAKIPFQIILDEIRDSVSNSRLERLHLLKKKDLYNIEKCFNLCSSSVRHENDAISVDAWVSEMKSSECVLFYKPQETICQENPELQYEDFFLIIMSDGQKDLLLRFGEDCICIDGTHGLNAYGFELHTILVLDDLREGYPTAFLISNRSDSIGMKIFFQCIKERVGKAIKPKVFMSDMADFYYKSWMQVMQPAEFRLYCTWHVDKAWRKNLEKVLNKEKKVQVYHMLRTLLQETDSTAFNQLLLNFLKYLKEDSDTLEFAMYFEQYYACKAEQWAYCFRLHCGLNTNMHIERMHRTIKHIYLHGKFVKRLDKAICAIMKFVKDKLFERLIVIHKGKVSTKINELRKRHVTSQSLDLNKVIKSDIGWLVPSNSRNEMYTIQKVKENCPCRLVCEDCEACLHCYTCTCLDSCIKWNMCKHIHLICKYTQMDLTKESTIPNINFLAGDADNLVIECDDEKRALIGAVSKIRRNEESSLKEAKEKLSLKITGQINDLESFDELKAVQKIVVPIKPTIDAIRNQKDINLGFPSTRRISSNKKIFPQRNFFPTKKIKGKKRSKLPKPHHQKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWB0</accession>
    <name>A0ABM5JWB0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502229.1">
        <property type="nucleotide sequence ID" value="XM_050646272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502230.1">
        <property type="nucleotide sequence ID" value="XM_050646273.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646272.1">
        <property type="protein sequence ID" value="XP_050502229.1"/>
        <property type="gene ID" value="LOC114324306"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646273.1">
        <property type="protein sequence ID" value="XP_050502230.1"/>
        <property type="gene ID" value="LOC114324306"/>
    </dbReference>
    <dbReference type="GeneID" id="114324306"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33194:SF4">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33194">
        <property type="entry name" value="ZINC KNUCKLE DOMAINCONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="471" mass="52973" checksum="5724DD553EA0911B" modified="2025-10-08" version="1">MSTFKVDHLLLKELDYELKIRSIDVTEYPTVEAKRKILRGALRQEKENRSFRQISSSCIPFDKHKEEIEDTLKDLTQKIGIFRGTILDPTFARLSSRVAHLSERVSRLECDTDEQELYQKTVAVKILDIEGDLDARGNPAATSTPNAPIHNASPFPFSKSAQVHKWGISFSGTGDRDTVVAFLEKVECLRISRCIPEDDLFAASAELFTGPAFTWFMNNRSNLSCWKDLVQKLKADFLPYSYQDDLLDDIKKRKQLQNEPVTMFINNILGLCSRLDIPLTESEKVRIIMKSLLPSYHSQLALVEIRSIDELTEKCKRLEETFSWSNQPSTVVSSRPFPSSSQNSFSRNRSWQNKVPKHNVSTVTSTIVCWNCYTQGHAFSACPNPRLRPFCFGCGLENTTKPNCRNCQGNGRLEDCTLSPPLTVSPSGNSVTSINNTGLNTSSPPVLSTSRKGKGISSKRTTTSNKNLSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWV0</accession>
    <name>A0ABM5JWV0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502416.1">
        <property type="nucleotide sequence ID" value="XM_050646459.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646459.1">
        <property type="protein sequence ID" value="XP_050502416.1"/>
        <property type="gene ID" value="LOC126881845"/>
    </dbReference>
    <dbReference type="GeneID" id="126881845"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="591" mass="66347" checksum="093ECF994A8CBE14" modified="2025-10-08" version="1">MSELSMAYNLALTEVNWKRNISLLSYRGRLFIIKLVFDNYTNFYHILKTKGRSGTETALLNSCIHPSLVKYFVEKGAKIDKANDIGFIILKFMFRKVRIYTNLSFYRKMFDIPNYNKSAVDLLKFLTREYAMNLNLCDQYGNTLSYYAAGSNSLEAIKYIKEQGANLNIFNMNKYTPVHIAANSGALEVLRYLVEDCKMDLTVSDDNGNLPAHMAADGNQVEILSYFKSIGIELNQCNNDRQNLVHIAAAADAIDVLNFLKNEYNFFLNIDLCDKHGYTPSHHAAAYNARKAIRYLKEQGANLSIPNKNKSTLVHIAAESGALEVLRYLVEDCKMDVTVSDDNGNLPAHMAAVGNRVDILRYLKSIEIELNQCNNKGETLAHKAAAADAVDVLNFLKNECKFSLNLDLCNKYGYTPSHHAAACNALKAIKYLKEQGANLSNSTMNRHTVIHIAAMVGALEVLRYLVEDCKMDVAVSDNNGNLPAHMAADSNKVEILRYLKSIKIELNQCNNKGETLVHRAAAANAVDVLNFLKNECNFFLIFLKYGYTLSHDAASCNVPNAIKYLKEQGTNLSISDKNKSTVFIHIYLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY04</accession>
    <name>A0ABM5JY04_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502820.1">
        <property type="nucleotide sequence ID" value="XM_050646863.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646863.1">
        <property type="protein sequence ID" value="XP_050502820.1"/>
        <property type="gene ID" value="LOC114330189"/>
    </dbReference>
    <dbReference type="GeneID" id="114330189"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046489967" evidence="3">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="456" mass="51861" checksum="E8D396682BB81275" modified="2025-10-08" version="1">MVPKIIFFALLMGIANTQRCIFPQLCQPGVVPFPAGIDPFNQNLVVSVNNDIFSIKNWIKQYFDELIQREVDIATGINNCISRLVAVENHLEQIDERDVTQLQNIQQTVIGIENNLPTILQKMENKIILTVSEHEPSSQISQPVISKKDFESLKKEIMNKIYIVTNSIGKIETEINEIKEENQYIKDLHKESTENLKIYFNNNQELFTKFGKKLDNCNNNINNKENEEWKVNITKAFNGQQSEAKKILAEVKEVQNKIDQLSQECNLAIHQNITLPKQDNSKSDLTNYIKKTHEETIKKLNDLSKTTDTLGHSCVTSCDKISTKIEGLNMSDKAIEKIAANITTKTKAQVEFGVNQILEEVSKYSKSSAIYVQEAVCNRLDSLKTSTLVNITSKIEDIQQVFQKIEILYQQMKSNGSALNQSKNCKTDSFKVNDTGIKGVRNDSDEKSDDQEIIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4Y0</accession>
    <name>A0ABM5K4Y0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505245.1">
        <property type="nucleotide sequence ID" value="XM_050649288.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649288.1">
        <property type="protein sequence ID" value="XP_050505245.1"/>
        <property type="gene ID" value="LOC126883634"/>
    </dbReference>
    <dbReference type="GeneID" id="126883634"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="253" mass="29596" checksum="A792F79B581759C0" modified="2025-10-08" version="1">MDSDTSDEINKRGREGDDGTFNESKKTARTAIDSHNQGNKLDQIIRMMQDLTEETKNLAAEVKDIKEDQREYWKELRELRDEIEKVKQANQKSQIEKDEMKKELNDTKLRLEKLEKERKANNVVIQGLQIDTNDRDILRQTIGNFMEAEMNIKVKIDEVIKLGEKTCLVKLPNHHEKETVMKNKAKLQHAKDRRVFINNDMTKEDLQVQKKIRQVGHEEANKGKNVKGINESLDDIKHKLTQLLNNLKLKLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K509</accession>
    <name>A0ABM5K509_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505275.1">
        <property type="nucleotide sequence ID" value="XM_050649318.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649318.1">
        <property type="protein sequence ID" value="XP_050505275.1"/>
        <property type="gene ID" value="LOC126883662"/>
    </dbReference>
    <dbReference type="GeneID" id="126883662"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32516" checksum="5C9E52726A799900" modified="2025-10-08" version="1">MLPWLKKHPLISDNLVIARRRLETTLNKLKKSNLFESYSLIFNEWLNEGVIEIVNNPEENNCVHYLPHMLVIKNSSETTKIRRVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFIQISVNSKDRDFLRFLWVNNGGKEFVFRHKRVVFGVNCSPFLLGATIEFHLIKALEKYNDMPYSKNTIERLMNGFYVDNCVTSVTDENELRKFVSETTAIIEEAKMDLRGKFAKYEMKRALPTKGLTPLLEDDSDCKNADYLDVVYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K557</accession>
    <name>A0ABM5K557_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505323.1">
        <property type="nucleotide sequence ID" value="XM_050649366.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649366.1">
        <property type="protein sequence ID" value="XP_050505323.1"/>
        <property type="gene ID" value="LOC114338469"/>
    </dbReference>
    <dbReference type="GeneID" id="114338469"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="393" mass="42985" checksum="B7177945DF3EE7D4" modified="2025-10-08" version="1">MRSVGQMCDGGFSAAEGLSRMASLGGASLGVPQTLQSGQAAKKQEDHIKRPMNAFMVWSRLQRRKIAQENPKMHNSEISKRLGAEWKLLTEDEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKPKTLRKEGYPYSIPYPSVPMDALRAGMAASSMSQSMASYYNPSAAYGSLSAASMAAAAAAAQQSAAAMSAGLTAPAQVVSSMDAMKYSMEADKYRSPYMPPSTLAMSMYSDPKYMDSPSKSYLERGYLDSTSALTKAYFESSKMYMDANIANKYNPDATRSYAHAGLELGKMYSDHHQHQQQHSQQVSMSSPRSSDSPDVKPMQDRLEGSSSSSSTTTSSAGASPGGLPGYYPSSAMQQSTAGLLPMAQYPGQYPSQIPGSEFRKPLTVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5C6</accession>
    <name>A0ABM5K5C6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505401.1">
        <property type="nucleotide sequence ID" value="XM_050649444.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649444.1">
        <property type="protein sequence ID" value="XP_050505401.1"/>
        <property type="gene ID" value="LOC126883778"/>
    </dbReference>
    <dbReference type="GeneID" id="126883778"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68985" checksum="A6EE149067E045FA" modified="2025-10-08" version="1">MADKLKKYTFQRRMAMNELGTLLSLSNSALTEVHKQSLFRVRYSELDDVLESFNKNHQNIVTNLLNSEPTDAQLDSEDIIRSQFLNDYYQIKANFADLFEDDDNSQKNEENIAASNAVQPPSNVRLPQLELVKFSGDFTSAITFFDLFDALVHRRPNVDDTEKLTYLIQSLEGPPLRLAKSLPLARENYIRIYGKLKNRYLNKRLRAMAHWCKIEEAPATMFKNSDSYSNLIDTFSENLSALENLGYKISDFVLAYKILTKLDQETHQRFELLHGSSEMPTFIQLSDFLESQCISFDSSLLSPCSPKDSNRKNKSPSKHNANKNGSKVNNRYSFFSKPNATPCSLCSADHHLKDCSLFLNKSPYERYNACKRMRLCFKCLEKHDSRSCSVTARCCHCNSSHHSLLHFKSSESATQGATSVAAVPTTASSDAQVNTGTLSSHAASLGSVTSKNSSVLLATAVVEIMDGCGLYQPVRALIDGGSMTSFVSQSCIRQLGIRHSSATLSVQGIGAIKSTVVGRVDLQIKPVDRVDPIFNCEAFVLPKICEDLPVVSLDVGHWSYIANLKLADPRFHLSGKVDLLLGADIFSQLLLEGKVQTPRGMPAALNTVFGLWVPVVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7H8</accession>
    <name>A0ABM5K7H8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506144.1">
        <property type="nucleotide sequence ID" value="XM_050650187.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650187.1">
        <property type="protein sequence ID" value="XP_050506144.1"/>
        <property type="gene ID" value="LOC126884254"/>
    </dbReference>
    <dbReference type="GeneID" id="126884254"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="426" mass="50232" checksum="091B8C42032B6D25" modified="2025-10-08" version="1">MEIKQEYSETCKVEIECNDLNDPLLDGFKCKIKEESNPESTNHTFDCLALKEFPIETVLYKVERECNDLDDHLLNGVKCEITEESYRESVFLKEFPIETEIEQDKNEPTCFKAKQNTKEGIPQEDKVKIEETFFEHSSHEEYFTSRHTEGKTVNKNTTVQTRQKSYNCEICFKNFSKTSSLKRHLLLHSGVRPYKCEICFKQFSEAHRLKTHNMKVHTRETPYKCETCFKQFSEAHTLKRHLKKHTGDKPYKCECCLKGFIEIGDLRKHLRTHTGEKPYTCEICFKQFVTAGNLKTHLVVHSEEKPYKCEICFKEYCQENSLKVHLRVHTGEKPYKCEMCLQQFSYTRGLKNHMRVHTGEQPYKCEICFKHFTESSSLRLHLKWHIGEKQHKCEICFKEFSQAGNLRSHLRVHTEGKLTKQRPGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7N8</accession>
    <name>A0ABM5K7N8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506206.1">
        <property type="nucleotide sequence ID" value="XM_050650249.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650249.1">
        <property type="protein sequence ID" value="XP_050506206.1"/>
        <property type="gene ID" value="LOC126884311"/>
    </dbReference>
    <dbReference type="GeneID" id="126884311"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045784101" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="628" mass="69797" checksum="614B83DDC8E26229" modified="2025-10-08" version="1">MLKSATFLCFVISVCSVDYYTERDVNAYEKLLNEAFESSKTYEPATSSLKYKALKSGPPEGDDGDYDFIVVGSGSTGSLLASRLSEISDWRVLVLEAGKFGNNVTDVTVMSYKATIMSDFNWGYYSIPQNNTCLGFEKNRCPHIRGKGVGGTSLLNALIYTRGNRLDFDTWCSMGNKGWCYNESLPYFLKTEHLHWTDRNAPMDLPYHNSTGLLWVEQPLPRTQHTKIFLEANEQMGYKNRDLNGVDQNGVMTMQINTRKGRRQDSGTAFIKPFLHRKNLKVLTEALATKIIIQNKIATGVEYLRNGVLYSARAKKEVIVSAGTINSPQLLMLSGIGPKKHLQKFKIQVVQDLEVGSGFSDHLQVYGMVYSSNLTEPIKTLREAIAEYLNNGTGYLAEAASTQALGYYKTILEPVAGYPDLELSFADTNLTSDALSRFYNWKADISAATGGINAASSFQIFVTPLHTKSLGTVRLKSASPLDYPDIDPNILSDPEGHDLESVYVGVQLAVNLTKQGPFKKINAKLQQKPIKECIQYEFMSRKYWKCASKYIVCHNNHSVGTCKMGPNPKRGDVVDNKLKVHGIKRLRIADASIIPLSTSSHINAICYLIAEKGADFIKEADGRLNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8A6</accession>
    <name>A0ABM5K8A6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506423.1">
        <property type="nucleotide sequence ID" value="XM_050650466.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650466.1">
        <property type="protein sequence ID" value="XP_050506423.1"/>
        <property type="gene ID" value="LOC126884522"/>
    </dbReference>
    <dbReference type="GeneID" id="126884522"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12576" checksum="B3B72FEB64F25C50" modified="2025-10-08" version="1">MEGEQLAKVTIPTVGEIEDDPRIALEKFKNNLENFKLKMQAFGGCLEYMQNSKMNERKKTEFVKDAKSKMDDMAKEMCELINRDVSDIQHKMELFWNELQENIVLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8M2</accession>
    <name>A0ABM5K8M2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506538.1">
        <property type="nucleotide sequence ID" value="XM_050650581.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650581.1">
        <property type="protein sequence ID" value="XP_050506538.1"/>
        <property type="gene ID" value="LOC114338778"/>
    </dbReference>
    <dbReference type="GeneID" id="114338778"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="470" mass="52797" checksum="8AF7BE7919A81548" modified="2025-10-08" version="1">MCTFQPEHLLVKEVDYELRIREIEVEESAKCDKKRSLLRGALKQEQGNRSFRQISAAAIPFLEQQQGINETLEDLTQKINNFRGTVHDSMYSRYISRLAHISGRVHLLCCSDEEQQLYKRSMSIRILSLEGELDSRVNPLATSTPVSSIQASNSLLHPKPVQVHKWGVSFSGEGHYDQVISFLDRVECLRVSRGVSEEDLFSASAELFTGHAFTWFMNNRGSFTTWTDLAQKLKSDFLPYSFQTDLLDEIKNHKQKPGESVTMFINTMLGMCSRLDTPLTDSSKIKIILKCLLPFYHAQLALVDIASIEDLTEKCKRLEETLSWSLNSPTTSQFNSGSVGFNSQPSRNRSWQSRPHTPNVSVTTSSFSCWNCREANHAFRDCSRPQTRIFCHGCGRGNTLKRNCFKCSGNEHAEARTLSVPQTATPSGNMTAAVDEASGPIPASSSNTPSQEGRNTSNRRPARKPKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8N4</accession>
    <name>A0ABM5K8N4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitric oxide-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506546.1">
        <property type="nucleotide sequence ID" value="XM_050650589.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650589.1">
        <property type="protein sequence ID" value="XP_050506546.1"/>
        <property type="gene ID" value="LOC126884594"/>
    </dbReference>
    <dbReference type="GeneID" id="126884594"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048422">
        <property type="entry name" value="NOA1/YqeH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21516">
        <property type="entry name" value="YqeH-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="NOA1/YqeH-like C-terminal" evidence="3">
        <location>
            <begin position="587"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="80602" checksum="487F2407D1DDC736" modified="2025-10-08" version="1">MLFLKSYQNVNCCKCSWLQKLEISKKYLSTNTYLYFPVETKLVNNNETEKSSTKDKLLFNSVLNAKNPRLGFFKARRLYAQQQELKHLIQPLPLSLKFLSDDLLTEKVTDKVEEQQISESNKNVQFPYSSVSSPVSEFKTEIKNEDLQEYSPETIDKEVRAKNNELRRWMNAYDNLERDIVEDGEDGTINYGTPDPKSVISDVPCGGCGALLHCKDTAIPGYIPSEIFKNAHRPGAATLEAIICQRCFFLKEHNIALQVRVSADDYPKVLMSLANKMSLVILMVDLTDFPCSIWPGIADILGPKTPIFVVGNKIDLIPKDDVKFIPNIKQKVVDYMKLNGFGTSKILDVALISAKTGYGIEDLITSLHSLWKVKGDVYLVGCTNVGKSSLFNALLGSDYCKIQAADLIQRATTSQWPGTTLNLLKFPVMKLSSHRLYLRNLRLTEMNKSTFVEENRRREQLKAHNVAENATLIGRIEQTFSKYTKYSRLPEKADSFSAQTQPNNSGRTTMGVNENHPDYASGRWCYDTPGVVHPDQLLDLLTLEELILTLPKELIRPETFCVKPGTSLFIAGLARLDYLKGPDSIKLTVFRSNELPITICDLNRADQTYEDCLGSELFKVPIDEGDRLSKWPGLSKGKPFTVTGVTRRLSINDVVLSNAGWISITCSGNQKYTLQAWTPEKRGIHLRDSILPKTVTLRGKRIKYTVQYEGHTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8W5</accession>
    <name>A0ABM5K8W5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506633.1">
        <property type="nucleotide sequence ID" value="XM_050650676.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650676.1">
        <property type="protein sequence ID" value="XP_050506633.1"/>
        <property type="gene ID" value="LOC126884618"/>
    </dbReference>
    <dbReference type="GeneID" id="126884618"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="377" mass="42971" checksum="217E10C90715C5AD" modified="2025-10-08" version="1">MQNGKQKKDLYVTIVLSESTASLLKLSLPHLNLTDPQNSRIFLISPSHYRCSKSLVDLKEENTPTTSQGVKSEILFKYQSLQEEKESRHITQDIFLYMSSDVGLFSKSNCSSKSVVYEGCYSEDSFELLYYKSAESISIGKSRSLFEARKIKKLPLLSARSVAHSNKLGINEKELYVALLDSNRNSADHMCRICHGGESIDDLLMPCRCRGTVALVHLKCLERWLKDSQHSHCELCMHRYKIEKSPRYSLIRSIFAYLRAPGPQLKEIIFDLVMFSLYTPTAIFSTYILMMMCESLVKSNVIQSGTVPSHIIAFSAVFGMAAIDFTYSSWVLYICQKHAEAWRDWYHSNSSLKVILPAIKLRPIKKKKNSLKEGDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K916</accession>
    <name>A0ABM5K916_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine/serine-rich coiled-coil protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506680.1">
        <property type="nucleotide sequence ID" value="XM_050650723.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650723.1">
        <property type="protein sequence ID" value="XP_050506680.1"/>
        <property type="gene ID" value="LOC126884655"/>
    </dbReference>
    <dbReference type="GeneID" id="126884655"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038838">
        <property type="entry name" value="TRIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753:SF1">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="38315" checksum="A2C265D92082B8A4" modified="2025-10-08" version="1">MNYFLPFAFNYTCKFSCGQSSYFPQMNPARVEWDIPPPPGTEDDLLPEPINDDPGHRSEKEMSIEKEDETQENEPTGRLIDLVNPYLKNPEYVEYEKRCLDRRFRSKSRSHSRERFRRRHSRSRSRSKGRSRRSRSRSRRRRRRYSSSKSRSRSPAFTPGGYYQRHRHKRRRSPKHSRSKSRSKSHSRSHKSSSKLKHRRSVQRSSEERDTDIQGMNSQFNQSVDDNTKDNVFKNDGSFLEMFKKMQEQQKKVEEPPPVVAPKPIPIFGKRRGGKVLKTGMVQKPKPPTSEESSSRDAWSMYMSEVRKYKAACCDDDSKSRPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA55</accession>
    <name>A0ABM5KA55_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507072.1">
        <property type="nucleotide sequence ID" value="XM_050651115.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651115.1">
        <property type="protein sequence ID" value="XP_050507072.1"/>
        <property type="gene ID" value="LOC126884838"/>
    </dbReference>
    <dbReference type="GeneID" id="126884838"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="227" mass="27153" checksum="A67EAF0A21C5CB6C" modified="2025-10-08" version="1">MEQICPFNTPTPNMNTPVISNLTINYSYPVNHLKSSPYYENDYSEQYADVNNPNISEQDNYQNYRNQNYHQQEYLCIVQRNLEWIDANRDGVFFNENMNYGNNYFQYKGNDDYNQNGGQHANDSDGYLDESLDINSYSDDSRDIKDAEFITKPRKERTAFTKNQIRELEKEFVHSNYLTRLRRYEIAVALDLTERQVKVWFQNRRMKWKRNKSGDRQNKAKHLKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAA7</accession>
    <name>A0ABM5KAA7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507126.1">
        <property type="nucleotide sequence ID" value="XM_050651169.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651169.1">
        <property type="protein sequence ID" value="XP_050507126.1"/>
        <property type="gene ID" value="LOC114329033"/>
    </dbReference>
    <dbReference type="GeneID" id="114329033"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045075572" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="102" mass="11108" checksum="17AAB6D82C576BFB" modified="2025-10-08" version="1">MKTSIVLAILACVGLTVSAPPKNDVLCDGCVALTQVIQDHLEQDLPLDELEEIVREGCSALPDPLADICKNKLIPAVYNIYHRFEDASPVEICTVLDLCETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBQ1</accession>
    <name>A0ABM5KBQ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507615.1">
        <property type="nucleotide sequence ID" value="XM_050651658.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651658.1">
        <property type="protein sequence ID" value="XP_050507615.1"/>
        <property type="gene ID" value="LOC114341115"/>
    </dbReference>
    <dbReference type="GeneID" id="114341115"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029614">
        <property type="entry name" value="CECR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092:SF1">
        <property type="entry name" value="CHROMATIN REMODELING REGULATOR CECR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDT" evidence="7">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="406"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1354"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1691"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1789"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1980"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2088"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1102"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1354"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1386"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1400"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1606"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1616"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1790"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1996"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2090"/>
            <end position="2099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2188" mass="246888" checksum="2EE6F714748CC34E" modified="2025-10-08" version="1">MFPTFISILDIQSWWEVPSIAHFCSLFRTAFNLLDFDIEDLEEALLTDGTEEYSWLQDLIVRLLSGCLKNNGISTFNYQMFLRRLFRQKCQEHDRYNPFNTDIDFQLLPLRTKVDILHALCDFRLDATDVLDQLKNLEADSLRVEPLGYDSNDSAYWYFYGTRLYREDFTSKNDKKKTVWQVICFTQDDWLQLTKKFKKSTNKAERQLHHTLSENFLPELPRLFKEKEILARKRLLATLPKRTSNRLKQQEKELTEENNFLNQYLKEQESKEAEAEVQKKDLESRRQKAYERRIKLRENKESDALSETSVDEMAGTRSKKAKKVEETKISKSGKKKEKQSDEPTIYTSKPTTVGRQTNNSLSAATGQIVIEQVKNPNKKKLKTSQVFRQTDEDLVTGMHKILDYVKNHEDAWPFTDPVEEEYAPNYYTVIRKPMDLQRMEERLDSGFYKSFDRFRADFQLIVDNCKLYNGAENEYTEMVDNLLQVFEKATEKYLDHISSSDDEIAIEFSNEEKSKSKNRSDEPVNEKTSTSRRKPMLVAQTDRKRERSESEESINSLRSHESPYREVNTRSAKHRKVEHVEETPEKISKAAKTKKEKDESKVKKEKEVMIKKQNEKDVKLKNEKVMVKTKKEKEEVKMKKEKEEVKTKKEKEEVKTKKEKEEVKTKKEKEEVKTKKEKEEVKAKKEKEVKPKKENEESKKSKASEKKNKAEVKEKETKKEKYLSKKALKNKTKKGNKKDKKKKGKTKTVSRSPSLSPPPSDSPPPSSPDIRFDFFPRTLKKPHQYESDIENSIQEDKHRTKFDKFFDDFSVLDHHFDQKIKRDDELLPFFPKPKEKHNKLRETIEKLKALSENKLKDEFDFELEHSKENKDKSKKVEKEEKHKTKNKEKAHKPFTKEAEIELEEGNNTMDSIQSDGQKTKKSTTSTSSNIISKAQAANFDALTIATEQTLKDINKWLDDTPKFAEFSSASNSPSYAGLDDLDTLTGKIDQVPGKKLDKPLTAIKKDAANKDPKKKPFRDPSKFFKRREVQRTIDRLQPGKSKGNLITNVQATSKADEVFALGPLSKLKDTKNSLIVKTNTNAPKLSLGSVLDSFGKHKFVDDQKKEEKQLEEVKLDEKPATPDIKMDVESSISIKKPEEEIEKKSQEPPVTDDTGSGGATPNLSAWFKAFGAPKVQPVTKRNDTKSEVEKEKNDESKSVDVRKVTLPLVSPSTDIHGQPISRQRRISTGSSMSERSSFSQDMDSPRVGMDERGAYPAPYPSPLHRSPTGASPIMASPRPDISPKTAYSTINGQIRVGFYQDTVSNKSSPDKSCSPQENSQSPYPHYSEHVYTPNTTDNSYYSYTNPPYYTHVPNYSSTNPTPPYNSEGNYSYYDSNKAQTPQNYTANSPASNHSSPHHQLSANVSPNMNADRSPGMNSPSVHSPNIHSPTVYSPHSPTILPQHSPNINPQYSPGLLPQQSPGVHPQHSPGVHPQHSPGVHPQHSPGVHPQHSPGVLPQHSPGMHSQHSPGVHPQHSPGVHPQHSPGIHPQHSPGIHPQHSPGVHPQHSPGVHPQHSPGVHPQHSPGVHPQHSPGIHPQHSPGIPPQPSPGVHSQHSPIVQRPPSPISASMCSNSSEVEHFQSQEELSKRGDKIQSQTAIFPVKKRAYNDNEILQISNQKFEIAPRLTQQIEMKKNQEDGSKEKVDAKPYVHQNIPDPKSLNIPNSEDFYPKPPAHTSQLPTAQAASAYNFNTDSNYSLNIPSRDRTIASSQSSKIDMSKYTNMGYTGPDVNTRSISQLGFPSTSIPATLSQKQASAQSSLVTSSASSSDMSMRYGNPNLALQQMGYKGVESTAPQQAHTNYESSVPPNARTEGINERLSQMQNVSNSSMSRSNYNASSVDVGRTMANLSHIVDRFSNEERVMVGLQNTPSFYGDKGLSSSHILNKPISSNASAMPIFSQANMAAIQSYNQNLQASSTSLYNRPMADLQNAGVMQSDLKNNQQIQEKKSKKRKSSKNVPASSSEPQQQTSTNQGFQSYAGLKGNSSLEPSAISLKTSSVVPGSAFNFGPTPAGLGIGSGIYADKDAYSNFLDEFRSTPNYYIAAAAAAHHRTPENTEKQTRPAHQNSNPQTYPFLGAPHARSTYPIAGPFIPNAQAQLMDTSSPLYQHYLQAGVLNQSLLPHPGTYPPGYHSALSMRQQYDSMNRPPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF83</accession>
    <name>A0ABM5KF83_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508854.1">
        <property type="nucleotide sequence ID" value="XM_050652897.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652897.1">
        <property type="protein sequence ID" value="XP_050508854.1"/>
        <property type="gene ID" value="LOC126886056"/>
    </dbReference>
    <dbReference type="GeneID" id="126886056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="487" mass="55031" checksum="6213AC757C63F3CA" modified="2025-10-08" version="1">MDTNSPGPPDKGGGIYALLSLNSQIFLNSIHMLAPRHKNNINLIEKELCALKNKFQNDQIMLTEVNNLSSRIENISRRKVEYKDTDFGPFLIMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMVLNSTEILEKGFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNVKIISARRLNRRVLDSNGTVTYIPTGTVQLLFDVRTPPKEIIIYSNLVTVDPYIPPVQQCFKCLRFGHSQRQCRGKGARCPKCSDEHTVQSCTVSVPKCLYCDLDHLATNKICKEFERQKKINEVMVFQDLTFFEAAKLFPPIKEKPENSRMFQRRSRVFPSLLSSSPRAFTQALQKSPSSTPHFQSQSHVVPVKRKNKVILKDISYDKEAHKALLNEDLSRNLPRLPILNKLNDSQKYTGSQVPSFALSLTSNRVHSQDSVFSKNVDLTSDNNMDFAGFDESHNTSNFSKSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFS6</accession>
    <name>A0ABM5KFS6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503474.1">
        <property type="nucleotide sequence ID" value="XM_050647517.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508151.1">
        <property type="nucleotide sequence ID" value="XM_050652194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509008.1">
        <property type="nucleotide sequence ID" value="XM_050653051.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518524.1">
        <property type="nucleotide sequence ID" value="XM_050662567.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519101.1">
        <property type="nucleotide sequence ID" value="XM_050663144.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647517.1">
        <property type="protein sequence ID" value="XP_050503474.1"/>
        <property type="gene ID" value="LOC126882549"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652194.1">
        <property type="protein sequence ID" value="XP_050508151.1"/>
        <property type="gene ID" value="LOC126885595"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653051.1">
        <property type="protein sequence ID" value="XP_050509008.1"/>
        <property type="gene ID" value="LOC114329200"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662567.1">
        <property type="protein sequence ID" value="XP_050518524.1"/>
        <property type="gene ID" value="LOC126892829"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663144.1">
        <property type="protein sequence ID" value="XP_050519101.1"/>
        <property type="gene ID" value="LOC126893186"/>
    </dbReference>
    <dbReference type="GeneID" id="114329200"/>
    <dbReference type="GeneID" id="126882549"/>
    <dbReference type="GeneID" id="126885595"/>
    <dbReference type="GeneID" id="126892829"/>
    <dbReference type="GeneID" id="126893186"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="419" mass="48400" checksum="EC60EE2E1DF14355" modified="2025-10-08" version="1">MSKRQYIRRGVQQQEPQPHIFDLYQKPLFDNTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFGIHETLLEIKGSIEKVGDGVVSLAPNVGAFLFDTCTYIQSSHDMEIVRDPGVVSTIRSLLCYTPEDSKFLSTAGWNYPNNPHISGDNFSLLIPIKHIFNIFNDYNKLTYGRQVFRFVRARNDRDCILVKEPNATTTTTVSLTVSSMELKVKHVFPNDDMKIELMTPIKNNVPITIPFRKWELNELPSLTSGSRREIWSVKTTSSVERPRYVIVAFQTSKRDDIHADPTLFDHIRMSSVRLVINGEYWPNERMQLDFAKNDYAIAHYNYTEFFPSYTLSSTKHPILDYAAFKKYALFVFDCSKQDDTSFRSGTVDVKLEIEADEGFPAGTRAYCLIVHDSLLEYFPLTEVIKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFV2</accession>
    <name>A0ABM5KFV2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509033.1">
        <property type="nucleotide sequence ID" value="XM_050653076.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653076.1">
        <property type="protein sequence ID" value="XP_050509033.1"/>
        <property type="gene ID" value="LOC126886213"/>
    </dbReference>
    <dbReference type="GeneID" id="126886213"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33857" checksum="34550D4AAFDF0482" modified="2025-10-08" version="1">MAENQAGSHVLANMATVSAPSEFNFSLPGSWNQWKKRLERYMSVSCFINKPEAEKIDMLVYLMGAEAEEIITQFNLTPAQQVYSIIIEKFDAHFIPQKNVIFERFKFNTRSQQPGESVDAYITALHSLAEHCSYGALKDELIRDRIVVGVLDVKVSERLQLQKNLTLGEAVLTVRQAELQNSQNRILRQERVQEVATVNAHRGNYWSQSQAEPNKYGQQNTWGKSNKNYKCTYCSVPSCNSRERCPAKDSRCRLCGKKGHWQARCRSGRNVRVVEGQNCAESEVGIENEMENLQVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHP4</accession>
    <name>A0ABM5KHP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingomyelin phosphodiesterase 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509648.1">
        <property type="nucleotide sequence ID" value="XM_050653691.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653691.1">
        <property type="protein sequence ID" value="XP_050509648.1"/>
        <property type="gene ID" value="LOC126886696"/>
    </dbReference>
    <dbReference type="GeneID" id="126886696"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024129">
        <property type="entry name" value="Sphingomy_SMPD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12988:SF6">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14724">
        <property type="entry name" value="mit_SMPDase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="97104" checksum="63FB1CFB68E8028D" modified="2025-10-08" version="1">MINMIKEQDFMAGVHHAMRLPVRARCAELTVLLDRGNLLELHNFFPVLIENIFGPQGTLSWGLRTTTESEAEDFRQLQHFLSPCGPVFKLIYTLLRDPNIRYEFSLAYLPLKIRQFLENSQGHPFYSDLLHVNGQTKQIVSLMLNAFDYYIFHFAYHLINPWQQRAGSSCWNTVYYVLCCDYILHFLPTDPGTPVLPVIYYNGKNPVQTTKIYLVDKPQSSGLIQTKKQMKDETMQTNLDYHHPRNDIWRSETVLTVFSDMWLHNNQVTETTNTLTTLNQLNVPHASRFLQHNELPTGEYMRIVRVLVKQLHSFHQSARADDTHLGELKKLSIPMIQGKFYIFLRNLIHRWPLDGSFRLVLELWLTFIQPWRYPPSNLIKHINKKEMNPYIDDLSTVPQTEVDVEFIPFIAENLLSYTVIFQQLLPRFGRVDLISPKMSLMLYRIAKVFDQPNLPKFLRDIEQCVDNNNSPTHSYNKHWVNNLPPLSPTTNWSTNTTVQNLTLSESFQSQKSSPSNTFLISRGGSEKKWSAVVRQKIFELEGPNFCYKPLFSCPPAPEVFDLIFQIKKSVRDAEDIVRAKEKEEQEMFSGFWGNIKYFFVGTDPNDEFTLRERQKVPLHLQVALQNIMDMFNISNEITEREYEPLNITPVTMNTSNDYKFLTPERIRARVKNIKYEGDPDLRPIQSYENAFLVRTLYQISQKLNEIYGPTFYQLYHSTTFVGRLSREILCSPITIYRYDKSTPGSPRISSNLPPRLSLRFLANYTFLGYLFFGAFVTWLFGYNINVYFIFLIFVFLLYKCYKAVRSRETPVRHNYPTQGFRNISFSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJM5</accession>
    <name>A0ABM5KJM5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Androgen-dependent TFPI-regulating protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136312"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:52073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:52061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52056"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83677"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52057"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:84201"/>
            <dbReference type="ChEBI" id="CHEBI:136330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:52077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136303"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:52065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136304"/>
            <dbReference type="ChEBI" id="CHEBI:136335"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52085"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:52069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52048"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:52049"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52052"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:52097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510318.1">
        <property type="nucleotide sequence ID" value="XM_050654361.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654361.1">
        <property type="protein sequence ID" value="XP_050510318.1"/>
        <property type="gene ID" value="LOC114336917"/>
    </dbReference>
    <dbReference type="GeneID" id="114336917"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29888" checksum="677D898D1390C7F2" modified="2025-10-08" version="1">MLDLANRFLGVIISKALGEQQPIKDSKQFLFHSVAVAHHLYVAWYSCTQVDLKDVTEPKIIIMVKYAPAYFTTWNFALQLCYFTLSAWCDLQNALPTKHERLSDILKIKSYIYTTFVFASGIFVTTLFWGLYHTDSEYIFPQVCQNFFPAMLNHSVHTVIFVFLVIEALYVDHPWYDLKLSVASFTIYFIIYHVVYFGVCAQLGYYIYPFFNLMSATGVATFIFSYYVWLIILIVIGIEIEKWKENKRKSIFKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKE3</accession>
    <name>A0ABM5KKE3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510670.1">
        <property type="nucleotide sequence ID" value="XM_050654713.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510671.1">
        <property type="nucleotide sequence ID" value="XM_050654714.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510672.1">
        <property type="nucleotide sequence ID" value="XM_050654715.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654713.1">
        <property type="protein sequence ID" value="XP_050510670.1"/>
        <property type="gene ID" value="LOC126887298"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654714.1">
        <property type="protein sequence ID" value="XP_050510671.1"/>
        <property type="gene ID" value="LOC126887298"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654715.1">
        <property type="protein sequence ID" value="XP_050510672.1"/>
        <property type="gene ID" value="LOC126887298"/>
    </dbReference>
    <dbReference type="GeneID" id="126887298"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="86416" checksum="38A686649A0E51AD" modified="2025-10-08" version="1">MSGIGELSCDIVQNLIKARDILFQNYTPREANIWLKHIKRHLTLFNKAIRYGDLDVPKLRRLQTNVGHLKTIKVEIQNFSHHVGAGMNKRNKVKWEEVTSSFASRVRTGIIINLAHKDVMQFFGDCFKLFKIRITNILKKFNVIKCNTAFCGKFIRKANQGENSEFKYFNTKNEIIDAGTDLTLWFHSNVIDKLMAKLSEFEEKGSGWALEKIISLEVNINKYEIGNGASSFIKLPDQIRNKNACINVKNNDEACFFWSIVSALYPSKANSDRTSSYPHYTTVLNVDGLETPMTIGGISKFEKQNDISVNVYGLEMNVAKEKTFYVTIPLRLCKIKLARHVNLLMIQDKYFLKLNDYEAPIEDDEIVDIKYHYCMIKNLSRLLSSQTSNHSHKIFVCDRCLNYFSSFDRLNDHAKYCERINDCKVSFPPYQHVKFKNHVYKQTTPFVVYADFEAMLQKIKNGPLKSKTIKHQEHKAFSAGYYVKCSYDESLSFYRSYAGTGCLEWYAKEMADLAMFVNGKIKHIVPMNIKPNTNGATDCHICEKPFVEEDVVVKDHCHFTGAFRGFAHQVCNLNFRKQFVVPIFFHNLSGYDSHFMIRQLAKKGSISLLPINKERYISFTLNDTQSAVKLRFVDSLRFLNSSLDKLATTLNTEDLRYLAREFPNAAPEQIELLRRKGIFPYEYIDSMDRLKETQLPSIDKFYSSLTNESISKDMYQHAQNVWQSFDIKNILEYSLLYMKTDITKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMS1</accession>
    <name>A0ABM5KMS1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centromere-associated protein E-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511468.1">
        <property type="nucleotide sequence ID" value="XM_050655511.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655511.1">
        <property type="protein sequence ID" value="XP_050511468.1"/>
        <property type="gene ID" value="LOC114328697"/>
    </dbReference>
    <dbReference type="GeneID" id="114328697"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1702"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1939"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1998"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2226"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2289"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2349"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2607"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2676"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2749"/>
            <end position="2828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2969"/>
            <end position="3055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3069"/>
            <end position="3122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="403"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1600"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1939"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1950"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1998"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2013"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2301"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2690"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2972"/>
            <end position="2985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3069"/>
            <end position="3086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3122" mass="352496" checksum="4DCE224714CB7765" modified="2025-10-08" version="1">MGLLDEVFAKKKEPARIRPVKNTPTKKVPDKSSRTTTTEKSASQPSGSSIFDSLKRVHGALSPSSKHRSTQKQDVKKSKTSTEIKTVDKDRDKDKIKDRDKIKSKEKEKDTGEGKRTWFRSPSKSNLRKEPIKSSTSSLNVGAGAQKVTSSGVDPKKKRPATGVFSDANVTFRKGQNTKIDGQTIGDNLSRASSVTNLDAEPKVAKGAKPRKSSSRDRIDKIGESRKNDKKGITRNNNQLDSGENPYHSVDSLSEEELLHLRKQLQEMAQEKTNLALQLGEQKGQLNILQKEIQKLKSFKEESNIQLEHLTEENTALRNRLRDVAHSPLSDNEKQQLLFDSHRHHSSAPASIATNIIDDNNGADTTCTTPDWDKHSSSNVSEVSVACLQDKINQMQETHYSTNEELQATLQELTDLQRQLTELQQENERLNEEKTLMFDSLCRQTERLNDSRSEVESLKQLLYQEKDDTGQFETAVEREQKLVDLLKSAQEEREGLLVKLEQLNNELQEARSGIIDKDEQIGQLRDRVRTLECTLDAKHAEHKLLDQELAQAKDQCSGKQIEINRLTDLLDNARTKINELEQDRALSDKSELDELLDNARKEKDTLESEVAHLKEQLAISKNEIEKLREQVSILQEECKVTRNNAKTTQSDLEYKCEKLVKEKNGLNEQLQEFQEALNEVQVQSQCQLEDKRQLSAVLSETQRNLSEAERKNIILESEVDELKKQRAEENEEWEKFQDDLLTSVRVANDFKTEAQQELQRMILENKQYRDRERQLKAEIDKLKGGTLDSTDKENLEMDLLVKRPNRRGRERPRQNSGNASSSSKSDKTTPPPSQANTVRRRENRSLKAKRLKTLSVEEEMLLKSLNSYHADIDKTIPDEFLTEEQKVIRKLKIIYEDDYLKVKPVAPKPKNQLAISKPLLDSVLTNPKLMAILKNPKVKTIEDMASFEKEAPEIRNIIRDIDRAARGKSEEFTRSEKRISLVGRSMSMDQVHEMENLNKNLRLYRTVETEDLTEENSPTIEHRVSSLVPSDSVSNFNKRYSDFSLVVKETIPENIFNQNVKYSTLERIVKTIPKNVPESKLSHEQRFAVKLLAALEERKNTLKKNDKAKSLPISKPTEESVLRNPKLKEIIYDPDIKEVRRKSESYAFTPIVEETLRPYKSYDNIMFTFDEKRRRVNMYNTPSETSSDTFSSAEFNVDASEVGPYESFSGPWRPPPPTPKPPRNVEFITFSKQSSVEQKETASPRPNSVEVLVTIHKVSSDNEMNKPGATKMTEVEMDKRKTKERSPDLDSLVYNDTIKKNPKEIKKDVKYVVKVSSDKEINKPDFTKMAELEVNKRKTKERSPDLDSLVYNDTIKKKPKDIKAEELKVDLLQDKIKKLTNREKLEQTSKKNMLEAETSTDNYHEIDNNVIYPPPLHFATVETVDIAPIESYNSLEYNDTFKRPIQRGKSFSENETDQTAAVTDTDETIKNITEKFNTIHKLIQEDKRFMDKSIEKELGKDDIGNMEESVVLRDKSDVHKNTVEYVTGPEVSNSTEIEQISDDILDGRPPQSPYDYRDILKENRFGVTSPLNYRMSYKDVVKEIKNRFSVNEQEFSSNKKSSDEADHGSRPVSEEIQVRRSKSSIDKEMEHIFEHYLKTRVSQIIKQTESKPQSDPELQVEASMVTSTPIEKSVEADLEEPQTLEIKRISLLSRSYNSSENIANSETEDHCSSSYGLQTPEANKSNESEIFDYSKLSPKELTFSDDSYFELKDGSAKRIVAFEDSVQTKESVERAQDSDTKNIAIEENAAQVVVVRDNNTVQPIEISEQIAKAVHDETKEPVEYTQDNSTNNIAIEENAAQIAIVTDNDTVQAIKISEQVAKAVHDETKEPAECIQDNTTKDIAIEENAAQIAIVTDNNTVQPIEIIEQITKADENDGLTNVGTVEDQEKVTSNLEAQTVKHTEPERNIRGSSSNALNTNVSTSSVSEDIVAEDDSVGQFAELVENVPDIINIIQEHPRRQHDSYEGQKESFDPQTCDTTPTNEVIVDDIDKNKDKASSPIYTITDIKYIKPLVANFILNDVQTATLSLESSNTSSADNQHGEIREEIDNKISPIPDFKITPGEDLPHPPDQFELTDEELNIIRRAKKQAVSRPVSGLNDQDLELIQSLSLTYLGNESVHTYNNDADNDQVTTEVDKAKQSPEIVEDDNELLKTTEDKVHPLISDTSHDDNKVIYTLSSGTVTVEPVIPKNLPKERSSVDADPQENLGSKSNASSLFEYDKTSVHKSKTLPIFKPDAADDLEAFLGTISTSRTGHGPNDQLRIKPDSSNQLKKDKIVPRKSKALPTSNPEAADDLEALLGAISTSRVVKGHKEKTPLKPGLRTRHLSPSKEDKLSPSKPEAFPVTKTNAADDLEALLGTISISRNKAPKKTLDKTGTNKASLENIDETVKMDIPSSDKKVPTQVAATKMIDSLNEVNDTVKDKTDLGKHRIIVDGSTDSGTNRVKLELINTEATKNPLDFDKPQIVTVQVDQDVNIENANTCAGIQANQEMDQNIQPISQKVVPGGDGETYNDEVKYLSETSGVLEPNQFKNVITESGTIKKRTERHTILLRNQHLDRKEVKSLSLEKDGDISSNNVSQRVRSRPKSDNLTDKRVKSFAQHFERLSKERPKKEPIYANINVLKNQRFMMSRHAESIEKKPLPVPRSRNHGSKDFDSLGDRRSTDSHEVMKNMSEHKNFSETKNPFVEEEVASSLATVLKVKGLPITTQVSSESSTQEKQESQSHVVTVSAKDEDNTEPAEVTKVETENQEETTEKPQLLSSVEKAQLWSSMEKPQDQREDSGEASSSYSVIAVTSTPEKLDLRIPSETQMHPIHESDASTLNLFNLEGIDSASIDGTDVGLYRSTTQEMNKKIGYDVTYLGELSDTDSYEDPKFLLKGDSQSKPKIIDFVPLDYATKSMFPNSSNIPEYQTLEREKVYHVLNSAPKSTVSKADIKQVDDVDDKPKNTNPFVEPEPNKSPEGATKLEGSIGQERSKSATDLNALPAKSQTKIDIQKRNIPLGSTSRSRSKIDLPKEIRNSTFSAAKKIFQELEAKNSPKHSSKDSETMRSSVNVPYLEKSEVSSSVHSSNKDELSPEEINEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNF7</accession>
    <name>A0ABM5KNF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511719.1">
        <property type="nucleotide sequence ID" value="XM_050655762.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655762.1">
        <property type="protein sequence ID" value="XP_050511719.1"/>
        <property type="gene ID" value="LOC126887862"/>
    </dbReference>
    <dbReference type="GeneID" id="126887862"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="261" mass="30450" checksum="9873D65B5C29A669" modified="2025-10-08" version="1">MLQGVSVDILKISKHIQKVTELFSSDRQNGEKEFDNIMANVETTANKLGIELTCPRVAAIQVHRPNHSTQTINEYYRKSIFLPYLDSLVQSLKDRFSDRNKPSFEIFNLHPKIMKDLSKEDFEKSINNINSTYCELLDNFKEQSILWFDLWRNTEIDAKALEKLNLIEVLEHEHACFLPSVAKAIQIALCLPPTTCTIDRSFSTLKRVKTWIRNTMSNNRLSGLCLLSVHRRKIKENKENFMQKVIDLFAMDTRRIQLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNT3</accession>
    <name>A0ABM5KNT3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWF19-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511850.1">
        <property type="nucleotide sequence ID" value="XM_050655893.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655893.1">
        <property type="protein sequence ID" value="XP_050511850.1"/>
        <property type="gene ID" value="LOC126887945"/>
    </dbReference>
    <dbReference type="GeneID" id="126887945"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="448"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="580"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="78529" checksum="235CC52653240B72" modified="2025-10-08" version="1">MKKKDCILLHNIDMICNYYIKGKSKKSKKSKRYSSSDSEDEWVEKEVVESKKKKSKHKKKKSSYSSSSDSQSSSDEGYMKKKSKKNKNYEYSSSSDSSDGDRSSKYKRSSYRSRSRSPPYKSNMESQESKLQKQESSAQREEWMNIQTKFLTSSNSDRKKERDEQKRLEREKQQYDPRSCDRELNPYWKHGGDGLPGFKKPALSDDEDSDRRHRSSGYRSQLPSTGSSSWRKKQDSDSKSTRPSSSTSNWKKKKDSEESKTSNTIDSPSIKHVPDTKEVTKEVPETVEYTEKDLNALAAKLVKAEIMGNQKQITELKEKLEQARKSVQQKGAGDEEVLLTQTDSRGQSKPLRLQSEYGEASNSRKKKKTETHRDNQRVRYFADDDKYSLKEMFENEKYQAGADQDKEFIKAYSKIKKNDDLDDIFSDNIREKQSDSKTDEKNRSKAIQDHKKVSKSLDNCDRCIQSECMLKHLMISMGDTLYLALPSFEPLTEGHCLIVPIRHTPCATQLDENEWSDILDVRKALVRLFKEQDEDVIFFESAKGLHRFPHMVIECIPVPKEEGDLAPIYFKKAIDESEIEWAQNKKLVSLKGRDVRKAIPKGLSYFSVSFGMEEGFAHVIEDEQLFPDNFAQEIIGGMLDVHHSKWRKPKNQKFEEQSKRVMEFSKKWKDFDCLANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT34</accession>
    <name>A0ABM5KT34_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513336.1">
        <property type="nucleotide sequence ID" value="XM_050657379.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657379.1">
        <property type="protein sequence ID" value="XP_050513336.1"/>
        <property type="gene ID" value="LOC126889265"/>
    </dbReference>
    <dbReference type="GeneID" id="126889265"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="119" mass="12948" checksum="F72FD17DF7F27FA4" modified="2025-10-08" version="1">MNGIILAGLGLAAVGFAGRYALRQMPNAAKTFNEAMKNLPKFDSASVANSKYYKGGFDQKMNRREAALILGVTPSANKTKVKDAFKKVMAVNHPDRGGSPYIASKINEAKDFLEKHSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KU60</accession>
    <name>A0ABM5KU60_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513729.1">
        <property type="nucleotide sequence ID" value="XM_050657772.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657772.1">
        <property type="protein sequence ID" value="XP_050513729.1"/>
        <property type="gene ID" value="LOC126889456"/>
    </dbReference>
    <dbReference type="GeneID" id="126889456"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="209" mass="24414" checksum="22EC8C1A5F90743B" modified="2025-10-08" version="1">MQRYKISSETCSKNKNYLPDDEKYRQKIRKLKQQHVILEHKETTKNPKINFHDSLPFIVHKIPISPQCKKLENKDNVKSIFKKILQQNCSQSEEKKTTLLENVAVGTSKPIVDINTLLNDSNVFKNRSVVTMWNEAVKNKPNRDASNLVRVCAKHRRQYSQQSKERKEHKETHIGLTTIDLHDCKNQRSTQKSLQGENNSTQVSFIEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX77</accession>
    <name>A0ABM5KX77_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514803.1">
        <property type="nucleotide sequence ID" value="XM_050658846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514804.1">
        <property type="nucleotide sequence ID" value="XM_050658847.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658846.1">
        <property type="protein sequence ID" value="XP_050514803.1"/>
        <property type="gene ID" value="LOC114333317"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658847.1">
        <property type="protein sequence ID" value="XP_050514804.1"/>
        <property type="gene ID" value="LOC114333317"/>
    </dbReference>
    <dbReference type="GeneID" id="114333317"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22438">
        <property type="entry name" value="KH-I_PCBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02396">
        <property type="entry name" value="KH-I_PCBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="53068" checksum="80B6658114827CFA" modified="2025-10-08" version="1">MDGRLEQNRLNDDSNLQITIRLIMQGKEVGSIIGKKGEIVKRFREESGAKINISDGSCPERIVTVIGSTNAIFKAFTLICKKFEEFQEINSGSSSVPRPPITLRLVVPASQCGSLIGKAGSKIKEIREVTGASIQVASEMLPNSTERAVTISGTGEAITQCIYHICNVMLESPPKGATIPYRPKPQVGGPVILAGGQAYTIQGNYAVPAHTDVSSSTVMPPLFAPAHPTPHPLPFCHPLTAAAAPAQLLAAFEPLKNGHLQAALPPAHLLPDIAGLGKSPLAGLAALGLGGLAPGGAGGLNPAALAALAGSQLRTANSRNQQNSNQQTHEMTVPNELIGCIIGKGGTKIAEIRQISGAMIRISNCDDRETGTSDRTITITGNPDAVALAQYLINMSVELQKANLEAQNSPSTGQSSNSNTNSSSTSAASPLASAIPIAQLLAKPGALNALTSLTALGGLTELLSGQGGGPPSIQTTGVHRAHKSYTPRMRSPGGGNEGGRIKNERNKFNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX96</accession>
    <name>A0ABM5KX96_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514802.1">
        <property type="nucleotide sequence ID" value="XM_050658845.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658845.1">
        <property type="protein sequence ID" value="XP_050514802.1"/>
        <property type="gene ID" value="LOC126890029"/>
    </dbReference>
    <dbReference type="GeneID" id="126890029"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045036630" description="Peptidase metallopeptidase domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="11">
        <location>
            <begin position="88"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="506" mass="57932" checksum="AC82A64A3A86C46B" modified="2025-10-08" version="1">MHINKVVLLIATSISFCLGGNFTETNAVSWLEQYGYITTSETASTDITETLEQFQERYNLPVDGKLNKETMELMQKPRCTQGDNAYAVKSAWKKFDIKWYFPQATPQALTVTKRVFEIWEEASKFKFTYLRIPDPNPDITITVVPKQHYFRYNCQGNDECPFKFTSGILAHSYFPPTSGCIEIHMNSNLTWDFSLNSTAEGRTNFFAVLLHEVGHALGLAHSSDKKAVMYPFYETFPSHITDDDKRGLEKLYGHKSKSASIPTQPRSSSPTTTERSRTTTAARTNKSKQNIITNVCELEYPDLIFLAYAPSFPTYRMYIVSKDLVWKYDLNNEKIPTNAEQFIRYFPRGITNVTHVFQSSNGDMIGVSRNRIYAAAFPSLRIHTDNMVPEINNARSINGLFQTNSGKKFVCFDGSFIEFNDKDIISRGRISDVFPGIPNDITSAFNYIDGHIYFLKHNIYYKFNEFTRSVIEKGTFNWNMLGIPCPDNGLIKQLKSLLSKVNLFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXH3</accession>
    <name>A0ABM5KXH3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamic acid-rich protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514898.1">
        <property type="nucleotide sequence ID" value="XM_050658941.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658941.1">
        <property type="protein sequence ID" value="XP_050514898.1"/>
        <property type="gene ID" value="LOC126890094"/>
    </dbReference>
    <dbReference type="GeneID" id="126890094"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68021" checksum="5BCD2384EA64AC95" modified="2025-10-08" version="1">MPKGDGEPEGKTALAGQGRTAPLDRSTRPNSWEGRWDKKRKTKKAEERAAGAKKKTEEAEKKKGTRIKGRKDGEEKWKKRKTPDLEPAQTEAREKKEKSQRKENAREEGESSSSDSSSDDESEEEEQTPNCNARTKLERLQDSVAALEKLIVEVPNTRVAIKQEVDNLRNRLFDYTEELEERKKKEEVPRKSVCTTSRGVQTNMQPLKVKKMATMGVQVDLENPEAIKRRVDAITEKMAICEYEEITEFLNEDWPEEVFQRTEVKEGDISDIAADVAVFVTNNDQDKKASVSLLFYNLQKLSLSVAAEETRRAECGRAAVAAQQVEEREVLWCNVLLSTAVNGANPEVDVVSGQSAEKKASSKKLGYRSQPKMTRVRSRSPPRSKALSPPRYADSKESLLLQHPEESSDDHSSDQEDGKDGFTIQNRRIRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTKANAEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKSEKKNPEKTDKKPPIFLIVTFSGALLENGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZR8</accession>
    <name>A0ABM5KZR8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor 172</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515682.1">
        <property type="nucleotide sequence ID" value="XM_050659725.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659725.1">
        <property type="protein sequence ID" value="XP_050515682.1"/>
        <property type="gene ID" value="LOC114331805"/>
    </dbReference>
    <dbReference type="GeneID" id="114331805"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1596"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1810" mass="203737" checksum="292A08E37BC8641D" modified="2025-10-08" version="1">MTSSRLDRLFVLLETGSSSVTRSAAAKQLGEVQRLHPHELKTLLSRTATYLRSTSWETRIAASEAIRHIVANVPQWNPQGVDIKEEEDGQSPSLSTIGRLRFSQFSMPTVLANSTHLMASEGKEFDLNDDPTMDSKERMAKQRQQLNARLGLNLAAQMGFDTSNLFTNEDLINNSDKMSSVSVRKNVQEVICPTNKELSLREINRAKRKARQAVSKQRSRDNLDDNSSEEPEKKKPKTELKEEYTSQFDVELGDAGDWPLEWFCDQLSQDLFSCSWETRHGAATALREVLSVHGSGAGKATYLSSNQMDLCHQIWLEDMAIRLLCVLALDRFGDFVSDAVIAPVRETCAQSLCAVMKLMTSQSCYEVLKILLQLMDHAEWEARHGGLLGLKYLLAVREDMIDSFLPESFPFILLGLSDPVDDVSAVAASALIPVAEKLTDLVPERIPEVVTKLWDLLSEQDELAAACNSFMGLLAAVLNLPKMQALLPAQPLNEVVPRLWPFLSHGTSSVRKATLQTLSTLTEKPKSGTAILWDAQLLQDALRHIYQRVLVEPNPDVRLVAEKVWYNLIENSRLVELLHAACPFITVWLYLCMQPVRLPFDTNFLIHAKSHKKKSDALNSFDHTVVPPKMYIGGIETTSTLVREQNAIPVRCAASRMLGSLSRYITKPAPGVDYATNGLENPIDSYVKVLMVHLNSKSALQRMVTGLVIAEWAKADKDVETCPLNLKTRLLECLNEFLYFDEIAHSFTRLAQETKDFLATLRHYKVPIPGNNENVLTLDQIEQVTGPETQSILVNIKMKPKVLESLEERRRNIHNSVSQTNKDQTRLSTSTMAAIAGAAVMFRVIPEKFVSMVKPLMKSLNNESNEELQKIAAEHLSILIDQTRDRQNNPNERIIQHVSNYLKSDPEYTPVIYKHQEEESSSQKDFLKPGNYNGIVTLNNQQRTAERAALKRCNSTGRGPGRPPATDIPMDELFKEEDEAQKTNAILRRGGTQALVALVKHFGEHVPTAVPKLWELMIGRLTESIDPFNFIAQDFYGKDEQAETILWSLQVLEVTVTSLHKSLLPEIMQKALIRLCVLLSHPYRAVRHLASRCLATFAKLDSVRVMEMVVSIVLPKLGATDCDIDRQGAVEAITCIVEELKFDIIPYVVLLVVPLLGRMSDQNMCVRLMGTHSFATLVQLMPLDGGVPEPPALKGSILNVRRDKEREFLHQLLTPSSIPDYHVPIPIEAELRSYQQAGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDQYDREQRYKETKSPDCASLPSMVICPPTLTGHWVYEVEKFLKHKYLRPLQYNGSPTEREKLRHKFRKFNLIVASYDIVRKDISFFSGIKWNYIILDEGHVIKNGKTRTSVAIKALVANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSRPILASRDPKCSPKEQEAGVLAMEALHRQVLPFLLRRMKEDVLDDLPPKITQDYYCELSPLQEQLYEDFSKSQAHQTLQESISASGSSGSIHNTHIFQALRYLQNVCNHPKLVLNATHPHYQQINAKLQEKNSRLEDISHSAKLPALKQLLQDCGIGVNDNPDKESTDIVINQHRALVFCQLKAMLDIIEEDLFKKNMPGVSYLRLDGSIPPIHRHSVVTRFNNDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMGLQKFKLQTANTVISGENSQMETMGTDQLLDLFSHKSTSNGDLASGSGKSGVGGMKAVLDSLPELWDSRQYDDEYDLSQFMSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZW9</accession>
    <name>A0ABM5KZW9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515734.1">
        <property type="nucleotide sequence ID" value="XM_050659777.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659777.1">
        <property type="protein sequence ID" value="XP_050515734.1"/>
        <property type="gene ID" value="LOC114345139"/>
    </dbReference>
    <dbReference type="GeneID" id="114345139"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027831">
        <property type="entry name" value="DUF4485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14846">
        <property type="entry name" value="DUF4485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4485" evidence="2">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="517" mass="60190" checksum="1E384FD707C2828C" modified="2025-10-08" version="1">MELEEQLDEDFLFYLNFTNTFLRRIQNEELSKRAQVWLQKLIGEPCEGVQKKRCRNIYLSNLLVGMQNGLLEKPFMAPARDTDILNAHEVFGPIPDTVELPSWLNDTELDTTRIHTSEGKGKRGRTYVATRTLPNGQGAFAYVGISLTNEEPMWLGAGESSFDQRMAEKFVEMVPPVTEMEKILARRKDPKYREKVLQFYDALMQHIADELDGKEVADNETIEGLIAQLIHDLTDKNMYDEYEQMEESERRIELLLILFDRVKIRRDKVAKREEILDEIEEKLVPPKSFFDVSEPAVEDKYKLPAAMWEQVIEKAPARKIMELLLQAYPLAVVKKYVIYLGDYKEQIAQRMQRRHENVVSQMKKELRKEGEKMKLTAEEAERACDNAMAVLAAVKEQYLKKLAEERKQGKEGKEDLPEHSQLYEKMKEAMYDTQKKVEEEALRGKFLASQINSLNEQTEHIMNVSVDIIKRTEEKNIRILRNIKKLKAAIHKYELVIHEIKNRTKQTATGTSFTVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0B6</accession>
    <name>A0ABM5L0B6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515880.1">
        <property type="nucleotide sequence ID" value="XM_050659923.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659923.1">
        <property type="protein sequence ID" value="XP_050515880.1"/>
        <property type="gene ID" value="LOC126890752"/>
    </dbReference>
    <dbReference type="GeneID" id="126890752"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="8">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="665" mass="76484" checksum="496542C2CA89E4A3" modified="2025-10-08" version="1">MELKVDTVNLFDLGKICRACLTEKGEMRSLFMQDDSTGQPLILAEMIMECTSLQIKDDDGLPNSICLQCSHEVSRSYSFKQLFEQSDINLRTYLGKPLETNPKHFKEEITTHQTDFTSSFLDSLGLESSSDSSDEDDFKDELLALQDTLSDNPQDEKVIAQKQLLKSAKFHKSRQARRKMLAKGGKVAVLAAKRMKRNSNQCNVCKKQFINLKSFRKHLRTHIEDRPFKCKICSRGFTEENYLNNHMRTHVPDEQKPHECEICKKRFIHSTLLSKHMLKHSGEKPFVCKICNKGCYAENSLLKHMKIHEKKEGDPGLLKHICDYCKVEFPDNQSLSIHIKQHTGDRPFVCNICGKCFPQRFNLELHARTHTGERPFQCEICKNGYVSKASLKIHMRTHTNERPFACDFCGKAFRQSGDLTSHKRLHGTEKPIECSVCQKRFTTVMKLKYHMRNHTGERPYVCSVCGRGFTVNTILLRHMRVHSGERPYVCVTCGKAFSQSSTLNTHMKVHASSNTNNQERTSKYTTIDDQKYTAQHQQQQDPNRLIQQDTRMLVQTQQLSDGTRILTETSQLLGDHRGLINDTRLITNEGTRLLVNVSEPTSLRLLVNDNTRLITNDNRLITQDNRLITNVNVNDNRHLSVLDGSRIITADKYLTTYDPYQRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0W7</accession>
    <name>A0ABM5L0W7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516082.1">
        <property type="nucleotide sequence ID" value="XM_050660125.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660125.1">
        <property type="protein sequence ID" value="XP_050516082.1"/>
        <property type="gene ID" value="LOC126890950"/>
    </dbReference>
    <dbReference type="GeneID" id="126890950"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="185" mass="21467" checksum="DD7069BC8C121DE1" modified="2025-10-08" version="1">MNRISTVEYPPVRERFGNTDLPQKYPRRNITQKNYYEGEEPANDRYVYCDTCKKDYVDFCSNCGTLVVLEDTPIRMGVEMRAKKTAPKGILEVQTSKIHGLGVFALRPLHKGVRLGPYQGQITRVNSTKGYAWKLKDGRLVDASDEKISNYLRYVNCARNVYEQNVIAFQYRGQLYYRTSKMILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1U5</accession>
    <name>A0ABM5L1U5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516412.1">
        <property type="nucleotide sequence ID" value="XM_050660455.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660455.1">
        <property type="protein sequence ID" value="XP_050516412.1"/>
        <property type="gene ID" value="LOC126891276"/>
    </dbReference>
    <dbReference type="GeneID" id="126891276"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="194" mass="22546" checksum="D2B6722A13143D2D" modified="2025-10-08" version="1">MARGKPTDPKVREIIINQYHKGKTMREISSELTVATSTVFNIIKKYGETASIDVRGKSSGRPKAVSQRSVRHLIRICKSGRRNTLREVTARWNRETGMNVSRECCRKYIHKNGLSFYKAKEKPLLTEAQKRNRYIWAKSKLSWTKLDWDKVIYSDESKFDVCVGDYRKRVIREKTEAVHKDCLKRTCSSTANVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2B3</accession>
    <name>A0ABM5L2B3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516577.1">
        <property type="nucleotide sequence ID" value="XM_050660620.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660620.1">
        <property type="protein sequence ID" value="XP_050516577.1"/>
        <property type="gene ID" value="LOC126891445"/>
    </dbReference>
    <dbReference type="GeneID" id="126891445"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="73"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="403" mass="47075" checksum="95E191E9170EBC0B" modified="2025-10-08" version="1">MDILNVLGQPFSDTTIEDYRFQQYQPFSTANLNYNDEIRISIQDLDALTLPCNSYIYIEGKISTDQNALPTKFKLINNGISYLFRELRYELNGVIIDVVRNIGLVSTLKNYLSYNENESKLLQNSGWFPKNGNLLIDAHGNFNVCIPLKIWSGVFEDFRRVVVNMRQELILIREKDDVDAVIATDETEKPKIQLNKLYWNIPHILPNISEQLRLNKIIRSNVELPIKFRSWELIEYPSLNNSTRHTWPVKTSTKLESPRHIAIAFQNGRKGKLLKDMSKFDHCNLTNVRVFLNSEKFPYHDLNLDFDTNRFATLYEMFANFQESYYHIQTNQPIFNPEEFKANTPIAYIDCSRQKEILQSSSVSLRIEFETNTNVGDTVSAYCLILHEKEFNYNPLTKIVRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2P8</accession>
    <name>A0ABM5L2P8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516719.1">
        <property type="nucleotide sequence ID" value="XM_050660762.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660762.1">
        <property type="protein sequence ID" value="XP_050516719.1"/>
        <property type="gene ID" value="LOC126891587"/>
    </dbReference>
    <dbReference type="GeneID" id="126891587"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="142" mass="15734" checksum="DF1FA2310691FC85" modified="2025-10-08" version="1">MQIDSTNSEKQTAFMSKSSEVSTKHVKKVNKKNITCFRCKQKGHYMNKCPSANNNAFSATFLSGNFKSTDFYVDSGCSTHLTARKDWLTNIRDASSSNITVANSESLEVKCAGDMMVTTIVDKKRLEKVLNILIFSSVGVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L390</accession>
    <name>A0ABM5L390_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Craniofacial development protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516907.1">
        <property type="nucleotide sequence ID" value="XM_050660950.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050516907.1"/>
        <property type="gene ID" value="LOC126891692"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12856" checksum="DAB62A8BF37F9DFD" modified="2025-10-08" version="1">MGDCNAKLGKEDYLREVIGKHSLHDTTNDNGHRLTQFAISNNMIIKSTQFERKDIYKVTWVSNDGRTHNQIDHVLIDARHSSSIINTRSTRGAAVDFFIVAFLLLQLTPWGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3G2</accession>
    <name>A0ABM5L3G2_DIAVI</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516982.1">
        <property type="nucleotide sequence ID" value="XM_050661025.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661025.1">
        <property type="protein sequence ID" value="XP_050516982.1"/>
        <property type="gene ID" value="LOC126891746"/>
    </dbReference>
    <dbReference type="GeneID" id="126891746"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF450">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
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            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="519" mass="60397" checksum="EF3D5ED8485BE825" modified="2025-10-08" version="1">MLIISFNFNTCNFKEYKYFDSLIPVCYKSNMEINQEASEKTSKIKVEKEDTYVSPLDAFKIEITEEPKRESAYEAFGYLDSNEFPLNTEVKQDEYKFTPFEEKQITDEESCAQEDNKLKIIEPLHSSHKGNKYTGHHIEGKILNKNVNVETGQKPYKCEVCFKQFAAKSNLKIHLRVHTGKKPYKCEICLKQFIKTCDLKRHNRVHTGEKPYKCETCFKQFSEAGNFRKHLRVHTGEKLHKCEICSKQFITTSDLKRHLKTRTGEKPHKCKMCFKQFNQGSSLKTHLKMHSGENPLKCEICFKQFSTPRSLKNHLRVHTGETPYKCETCFKQFSEAGNLKKHLRVHTGEKPHKCETCFKQFSTPGSLKNHLRMHTGETPYKCETCFKQFNQGSSLKTHLKIHSGEKPPKCEICFKQLSTLGSLKNHLRVHTTEKPYRCETCFKRFSEAGNLRKHLRVHTGEKPHKCETCLKQFITTSGLKSHLKTHTGEKPHKCEIYFKQFSEAGGLRRHLILHSGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3J8</accession>
    <name>A0ABM5L3J8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517017.1">
        <property type="nucleotide sequence ID" value="XM_050661060.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661060.1">
        <property type="protein sequence ID" value="XP_050517017.1"/>
        <property type="gene ID" value="LOC126891787"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
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        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
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        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="608"/>
            <end position="640"/>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="674"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="EnsemblMetazoa" id="XP_050517017.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
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            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="88132" checksum="28AC612030152F37" modified="2025-10-08" version="1">MDSTYPSTSTSPTSTNSLPGACHLCSKIFKNVELRNRHIKRIHKTDVPPRTNNKMNQNHIICPLCDQETNFESHEKLRKHLQDCHQLSIELITFEFSSKQEYETWKDMQKIETSYACSKTKRGKEHKIMYYDCNRSDLHGYKPNYKIRTEKAGGSIRIKGVCPSRLACKLRDQGQVSVSYWKTHVGHKEELRTMHLSKAEEKTVVEKLMAGVPPTRILKDSRKLEVPQLDRLAVITSQDLRNLTKKYNIHKKRDQNDMIAAALKVQEWNANNKNYAFLFKKEGEDHDILRKEDFAVGFMNAVMEEKLLEFPNIICVDGTHGTNKKGLDLTILLVKDDRNAGFPVAFLLSNRLDQQIQEVFLDALKNKIQTEVNAEYFMSDDDPKYYNAWKKIMRQEPRRLLCTWHVVKNWNIRGKKKLQDPTLKAQMKNELRQIIREPDEDKFKELCDKYVSKLEEANEIEFVSYLKNHYLAEHRKKLWPYCYRRNAGINTNMAIESLNNLLKTNYLKRNAAVGIEKLLDTMDELVEEKMWTRIVDIIRPSANNYQDRLSIRAHKRAASMKGKLEELVKETAYGHYEVKSFKGMNILRYVNFRKVCESECKTLFCRVCKICIHRYWCSCDDYMVRNTLCQHVHLVRMYEERLGSNSVVDDAARCLGEMSTIKSRHEEEINEFVRGKLEQTNVTQEKTKRSLQQEYLINVLNGLDDQGFTEYIRRTQGILEEVNNKAKNITKKRKMETQEYFHSKKKKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3L0</accession>
    <name>A0ABM5L3L0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517023.1">
        <property type="nucleotide sequence ID" value="XM_050661066.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661066.1">
        <property type="protein sequence ID" value="XP_050517023.1"/>
        <property type="gene ID" value="LOC114337596"/>
    </dbReference>
    <dbReference type="GeneID" id="114337596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="128"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="318" mass="36745" checksum="077FE401E6E1CB36" modified="2025-10-08" version="1">MLYTAKSSSDLSLTDLVRDIKMFFELYWQYFVMGLILYLVVRGGYVFFNKQQKKDKLRMEKKDDDCRSSFELNSLSSSSSTSSIDEEDEDHLLPALPKDLNHVPLEFVKLPVDECLTRSEEFFKLMNKRRTVRHFSDETVPVEIIHNIIRTAGTAPSGAHTEPWTYVVVSNPEIKQKIREIVEAEEELNYNKRMGKVWTTDLKPFKTNWLKEYLTEAPHLILVFKQLYSFRPDGKKKMHYYNEQSVSLATGILLAAIHYAGLVSLTSTPLNCGPALRTLLDRPNSEKLTLLIPVGYPREDCLVPDLKRKSLEDILVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4T7</accession>
    <name>A0ABM5L4T7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L-like proteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517451.1">
        <property type="nucleotide sequence ID" value="XM_050661494.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661494.1">
        <property type="protein sequence ID" value="XP_050517451.1"/>
        <property type="gene ID" value="LOC126892059"/>
    </dbReference>
    <dbReference type="GeneID" id="126892059"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045514880" description="Cathepsin L-like proteinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="112"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35133" checksum="E8CE19A48B268BD4" modified="2025-10-08" version="1">MKLLLVIACLIAGITADLNDYDQYVLFKAKHSKQYRITEDKLRFQIFQNNLREIEEHNARYAKGEVGWFKGVTPFADWTKEEFKALLTRQAASKPKLTDNLGSCIANSNVTLPLFVDWRFKDAVLPVRDQGQCGSCWAFSVVGALEGQVAIHQNQRVPLSPQYLNDCSKRNNGCSGGMQEDTFEDIQSIGICADADYPYVAQDQDCRTDVKKAISSISGYKKCNPTEEDLISAVATVGPISSTVDASTWSLYAGGILDDTNCGDWLNHAVLAVGYTDDYILIKNSWGEDWGEEGYIKLARGHNICAINEDNSYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5B3</accession>
    <name>A0ABM5L5B3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517624.1">
        <property type="nucleotide sequence ID" value="XM_050661667.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661667.1">
        <property type="protein sequence ID" value="XP_050517624.1"/>
        <property type="gene ID" value="LOC114330664"/>
    </dbReference>
    <dbReference type="GeneID" id="114330664"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="520" mass="59608" checksum="FBA6A2412EABBC90" modified="2025-10-08" version="1">MPKHRDVPSLQSLCLKSIGTLVVHVAPLILSKISIYKEPQKVISSLQTSLTWLNDHLSSHVPFYLYDQMAVEVLLAVKVFIEATKKTYFPHTSIATFLTEMNVAVSLTEVVLNCHLKSIDFSQWPKIMRYILYKNLHNLTGLENLNLGSCSGGWRTSEFDRCLLESIAKMKHLKSLCLCFDSTDVIVQTVGDNCQQIQCLDLTSSGSVTDRCIPFLLKCRHLKELQLHRTSVTTEGLAQLIVGLPKLQDIGRCDDFGKVIKYLYHKFPSEGPFELRKIQTRDISTENLRLLVDMFPKIEYVSLFHDVQISDLTVLISLDNLKDLKLLSCAFYGDYLKQLLEIRGTNITSLHLEHVEEMDYKVLIDISQCCPQLKNLVCYNCDFRNSVVPYHKLKVQPFLDLERIFWVVDSASSHLEFILNHAYNIRYIHLGSSTGITHAIMVKVLNTNPMKWLEELRVLYSSDMNMRTVELLMASCTNLKVLSELESWQGITLEQLHTFKQYIRSNNFNLDISPTLSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7C8</accession>
    <name>A0ABM5L7C8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050518347.1">
        <property type="nucleotide sequence ID" value="XM_050662390.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662390.1">
        <property type="protein sequence ID" value="XP_050518347.1"/>
        <property type="gene ID" value="LOC126892734"/>
    </dbReference>
    <dbReference type="GeneID" id="126892734"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="415" mass="49508" checksum="7BA82C94495E4193" modified="2025-10-08" version="1">MHLRIHTGEKPYQCEICFKQFKHLNLKTHLRLPTGEKPYKCEICFKQFSQQGSLKIHLRTHTEEKPYDCGICSKHFKNVGILKTHLRLHTGEKPYRCEICSKQFSLQGHFKSHLRTHTEEKPYQCEICFKQFKHLNLKTHLRLHTGEKPYKCEICFKQFRQEGNLKTHLRTHTEEKPYQCEICSKQFKNVRSIKTHLMLHTGEKPYKCKICSKQFSLEGNLKIHLRTHTGEKPYKCEICFKQFSQDGHLKSHLRIHTEEKPYKCEICSKQFSQDDYLKKHLRIHTEEKPYECEICSKQFKHLRNLKTHLMIHTGEKPYKCKICSKQFSIEGNLKIHLRTHTGEKPYKCEICSKQFSQDGHLKTHLRIHTGEKPYRCEICSKQFSENGHLKRHLRIHTSEKPYPKFVLSNLVKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7S5</accession>
    <name>A0ABM5L7S5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518492.1">
        <property type="nucleotide sequence ID" value="XM_050662535.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662535.1">
        <property type="protein sequence ID" value="XP_050518492.1"/>
        <property type="gene ID" value="LOC126892801"/>
    </dbReference>
    <dbReference type="GeneID" id="126892801"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="667" mass="77782" checksum="372DD46C17CED5C2" modified="2025-10-08" version="1">MEPLKKPKEQEKKEDDYRQKKQDEAKTNKNENGEELSHDGKKTEEIEERKKFEEEMLKRHQNQPKINRSGPITHSTLLDNMLEETNREEEEKEEDAEEREPSAEAIEVEGEENKREEQTETHWQKTGDSILQALLFDDEDYEAIQQSKKRKGDSLEENERFKKEKREETAEYPEETENERILRKLKQVLEILNNKGPIQGEHKIIARNLIGEIYNQNKTSLNQSKKTQAEEESIRCEQCKIKIEREKQRKETEKIIEVLNKGGDINDFNQIYEKRWEETVYEKTKWEQGGLQETIAKKECLIVTKNEIKEDGIESVIRTIREEVHEIIEGCQEGNVEYIENGNRSSMATVRREWYTYVAKIKDQGIYEVAEKALKQIKERKEPPEIIRVAINNEINKEKVRKALEFVGRREKITWEIIIRGKEMDKEVKNEQEEALLIKTGSKSYTDVLKEMNAKINIGKIGVKVDRLKKTEGGDILVKLKGRGAAEKLKREMDTKMSGISMAVRRKENYFTITGLDPGVTVKILHEAIQAYTGISQDEVDIKMLRTNQHGEQVATIAVRPTKAEELRRYTTIAIGWVFCPIMERYTPMRCYKCLHYGHSTFECKGESRVACCYNCMKTGHTAVQCGNTAFCLTCNEEGHRMDRMQCPAYRAWVYGRGREREPPKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L842</accession>
    <name>A0ABM5L842_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050518605.1">
        <property type="nucleotide sequence ID" value="XM_050662648.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662648.1">
        <property type="protein sequence ID" value="XP_050518605.1"/>
        <property type="gene ID" value="LOC114335164"/>
    </dbReference>
    <dbReference type="GeneID" id="114335164"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="97"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="771"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="15">
        <location>
            <begin position="987"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1009"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120036" checksum="1300CADED6862217" modified="2025-10-08" version="1">MADEIKNVVENGGDAPPKTAKQLAKEAAKQAKLDKLKQKLEKQQNAAPKKDKEEKKEKKKEVKEAATYSISTLEGEKKDTTVALPDAYSPKYVEAAWYSWWEKKQFFKPEYGRKSILEPNANGKFVIIIPPPNVTGALHLGHALTSSIQDSLVRWHRMKGETTLWNPGCDHAGIATQVVVEKKLWREEKKTRHDIGRENFVQKIWKWKDEKGVRIYHQLKKMGASYDWDRAAFTMDPKLCKAVVEAFVRLHDDGTIYRSNRLVNWSCTLKSAISDIEVDKVELPGRTFLSVPGYDEKVEFGVLVHFAYQVEGSDEKLIVATTRVETMLGDTAVAVHPDDERYTHLHGKYVTHPFCDRKLPIVVDDFVELGFGTGAVKITPAHDPNDYEVGKRHNLPFINIFDDEAIIVGDYGKFTGMKRFHARKEIVTALKEKGLYIDTKNNPMVVPICNRSKDIVEPMLKPQWYVRCGEMAQEAVNAVNNGDLKLIPEVHVKIWHHWMEGIRDWCISRQLWWGHRIPAYFVTMKSKPQQKLLPGSDDGEFWVSGRTKEEALKKAVKKFNAKEDDLILTQDEDVLDTWFSSGLFPFSIFGWPDETQDLQAFYPTSLLETGHDILFFWVARMVFLGKKLLGKLPFKEVYLHPIVRDAHGRKMSKSLGNVIDPMDVITGMSLEGLQQQLIDGNLDAKEVEKAKQGQKQDYPDGIPECGTDALRFALCAMCSGRDINLDIMRVQGYRFFCNKIWNATRFALTYFAADFEAPLDNKLIGNESLMDLWMLSRLATAITDANRSFAAYDFAAVTTAIYNVWLYELCDVYLEILKPVFASDDDEAKKTAQITLYRALEIGLRLLSPFMPFITEELYQRLPRPKEVAQIVPSICVASYPSEKEYYRWKNEDIEDEVDFVQRVVKSIRSIRGDYNLQNKTKTEVYIQCNDEMTAEIILNYESALQTLAYCSKSPVNETAPPGCTIITVSDKCEVNLLLKGLIEPSKEITKIQKKLDFLQTTRERLNKTMEAPDYESKVPSEVRHSNEDKLSQTSAEISRLEAALSSLRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9J1</accession>
    <name>A0ABM5L9J1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519104.1">
        <property type="nucleotide sequence ID" value="XM_050663147.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663147.1">
        <property type="protein sequence ID" value="XP_050519104.1"/>
        <property type="gene ID" value="LOC126893192"/>
    </dbReference>
    <dbReference type="GeneID" id="126893192"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037357">
        <property type="entry name" value="COMMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21758" checksum="DD78A03F775AEA70" modified="2025-10-08" version="1">MNISELSKNTINLVSEIPNDYRNKILKLVFSSYLLTEQERTKTVLNLSRDISIPKEDLEEILGVYLMFVTLFLRFDDNEFVERLTEIGFSPEFIENLPLIGNRESIIENLRRSYTETFGKLSLFRWRIDISLSNSDLVKVPNVVVLSITLSNRKKYTIELDPTTFHKLRYSVSFLLNQLNSLRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0U7</accession>
    <name>A0A6P7F0U7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC114325346</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129204.1">
        <property type="nucleotide sequence ID" value="XM_028273403.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F0U7">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273403.2">
        <property type="protein sequence ID" value="XP_028129204.1"/>
        <property type="gene ID" value="LOC114325346"/>
    </dbReference>
    <dbReference type="GeneID" id="114325346"/>
    <dbReference type="KEGG" id="dvv:114325346"/>
    <dbReference type="CTD" id="107980446"/>
    <dbReference type="InParanoid" id="A0A6P7F0U7"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043208">
        <property type="term" value="F:glycosphingolipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002064">
        <property type="term" value="P:epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035214">
        <property type="term" value="P:eye-antennal disc development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030718">
        <property type="term" value="P:germ-line stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036011">
        <property type="term" value="P:imaginal disc-derived leg segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008587">
        <property type="term" value="P:imaginal disc-derived wing margin morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046331">
        <property type="term" value="P:lateral inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061326">
        <property type="term" value="P:renal tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016330">
        <property type="term" value="P:second mitotic wave involved in compound eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048100">
        <property type="term" value="P:wing disc anterior/posterior pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000007">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000294">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000431">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000613">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000146">
        <property type="entry name" value="Putative neurogenic locus notch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026219">
        <property type="entry name" value="Jagged/Serrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF13">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1I6</accession>
    <name>A0A6P7F1I6_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114325337</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
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        <property type="nucleotide sequence ID" value="XM_028273390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1I6"/>
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        <property type="interactions" value="1063"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_028129191.1"/>
        <property type="gene ID" value="LOC114325338"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050498603.1"/>
        <property type="gene ID" value="LOC114325338"/>
    </dbReference>
    <dbReference type="KEGG" id="dvv:114325338"/>
    <dbReference type="InParanoid" id="A0A6P7F1I6"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    </feature>
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        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="416"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028129191.1"/>
        </source>
    </evidence>
    <sequence length="887" mass="102116" checksum="DC9D0C62495392D7" modified="2020-12-02" version="1">MEEESEAEEKNKKYTIIVSGLVIHFLLLLAVFDVYFASPLDNGMSPIRSTSNPPAKRLVLFVADGLRAEAIFGEGKEELIPFLADKLKNVGSWGVAHTRVPTESRPGHVAMLAGIYEDPSAILKGWKSNPVNFDSVINQSTNAWAWGSPDIVKIFNKDNLSKIHISSYDAQIEDFGKQDTGILDTWVFQKVHNFLTNEVKSCTQDCDQYFKNGNTFFLHLLGIDTAGHGYKPHSKEYKDNIRLVDRNIAVITELFNNLYQDGLTAFVFTADHGMTDWGSHGAGTDHETQVPVITWGAGIAKNHKRQDINQIDLAPMLASLIGIHIPINSLGILPVNYINTSQENKAQMMKSNVLELLEIYNRKRLRTKNGALFYIPFKHDEFINEKLNKLEILNAKSQTDYLISECQNLIEVLISGVNYYHNYYQYPVLLTVSLGFILWVIFLCLSVFGIKRRKVTNKSLDLIIFLLVIGTTFLCAKSQFSFTYYLYFNFPILVFFLLLKDREFYKFPLQVTYPNIVQVVYYIIGIELMVYGFYNRLSFSVIMILIASWINISKSLRISSSSAEKTTWVVCSIILAIFPCLPVMRTSFNLPIYIAGYVGYLLIFLKIYFYDLKRYNQLSSLQLHYRIYLLQFFFLQIAAVYVLLIEFEYIPSDSVLKGVSWVIFIVPILVIPLTDKYVALRLVATVFGFAPFYLMVSPNYEVLFSVFYILLLYTWLLIESKTFKYESSHKLIYFMRFEHYKSESFVNTDDFRRAFLFVVFIFVGFFGTGNIASMNSFDPMWVRAFLTVFSPFKMMGLILLKFIVPFIFTCSIFRAINEVGKQNVMNIFCIILIFSDLMVLQFLYLITNVGSWLDIGTSLSHFIIMDSFVTMLLLLYGFAYWLMSIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1M5</accession>
    <name>A0A6P7F1M5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 68-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114325611</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129514.1">
        <property type="nucleotide sequence ID" value="XM_028273713.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518885.1">
        <property type="nucleotide sequence ID" value="XM_050662928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1M5"/>
    <dbReference type="FunCoup" id="A0A6P7F1M5">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662928.1">
        <property type="protein sequence ID" value="XP_050518885.1"/>
        <property type="gene ID" value="LOC114325611"/>
    </dbReference>
    <dbReference type="GeneID" id="114325611"/>
    <dbReference type="KEGG" id="dvv:114325611"/>
    <dbReference type="InParanoid" id="A0A6P7F1M5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028129514.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="71571" checksum="48EED28768016FEC" modified="2020-12-02" version="1">MVKSPAVGIDLGTTYSCVGVWQHGKVEIIANDQGNRTTPSYVAFTDTERLLGDAAKNQVALNPSNTVFDAKRLIGRKFDDPKIQQDIQHWPFKVISDGGKPKIQVEFKGERKTFAPEEISSMVLTKMKETAEAYLGTKIVDAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLKGEKNVLIFDLGGGTFDVSILTIDEGSLFEVKSTAGDTHLGGEDFDNRLVNHFADEFKRKYKKDLTSNPRAIRRLRTAAERAKRTLSSSTEATLEIDALYEGIDFYTRISRARFEELCSDLFRSTLQPVEKALNDAKLDKGHIHDIVLVGGSTRIPKIQQLLQNLFNGKTLNLSINPDEAVAYGAAVQAAVLSGETHSKIQDVLLVDVAPLSLGIETAGGVMSKIVERNSRIPCKQTQTFTTYADNQPAVTIQVFEGERTMTKDNNRLGTFDLTGIPPAPRGVPKIEVTFDLDANGILNVSAKDTSSGKSRNITIKNDKGRLTQQEIDRMLSEAEKYKEEDERQKEKITTRNQLEGYIFQLKQAAQESGDKLSAEDKATVERECDSCLKWLDRNTLADKEEYEDKQKELTRICSPIMSKLHQSGGQGNTPYGGGMPGGCTGQTAGDGYGGKQGDGSGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F507</accession>
    <name>A0A6P7F507_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Runt-related transcription factor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114326376</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130535.1">
        <property type="nucleotide sequence ID" value="XM_028274734.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130536.1">
        <property type="nucleotide sequence ID" value="XM_028274735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F507"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274734.1">
        <property type="protein sequence ID" value="XP_028130535.1"/>
        <property type="gene ID" value="LOC114326376"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274735.2">
        <property type="protein sequence ID" value="XP_028130536.1"/>
        <property type="gene ID" value="LOC114326376"/>
    </dbReference>
    <dbReference type="GeneID" id="114326376"/>
    <dbReference type="KEGG" id="dvv:114326376"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000001">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF49">
        <property type="entry name" value="PROTEIN LOZENGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028130536.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49241" checksum="5676E7C69BB2D973" modified="2020-12-02" version="1">MHLPVSVQTCNVSEEAWPKSSMGEPPSVYQNPDLYWFEHKIHEIQAEHSGELVRTGSPYILCTQLPNHWRSNKTLPMAFKVVAVGDIGDGTIVTVRAGNDENCCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSITITISSSPPQVATYNKAIKVTVDGPREPRSKTSVQHQSYRTVGLGQRPFLETTSFSHLRDLEMYKNKSVRLAQTADGSLNSYKQESSDDNPSSTTHCPSSSWPEYTNSYAPYSPQTNYYDPHQDSTHATPIHLPTVLPDSSSNEYITTSLTSPPPLFNSAKPDLEMISSRYPDNNSYCPNNWPANSTAYNNNYYNHSYNQQQYLNTPTMVVYPSLYSTVNQSQIHFHLHPPSDKLDPYKNEPYIKSEQYLTDSAGLTNPQRVEAVQNSDVVHSHVDSLRIEDSERNAQSQNDPSVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5W4</accession>
    <name>A0A6P7F5W4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114326870</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131124.1">
        <property type="nucleotide sequence ID" value="XM_028275323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5W4"/>
    <dbReference type="FunCoup" id="A0A6P7F5W4">
        <property type="interactions" value="1562"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275323.2">
        <property type="protein sequence ID" value="XP_028131124.1"/>
        <property type="gene ID" value="LOC114326870"/>
    </dbReference>
    <dbReference type="GeneID" id="114326870"/>
    <dbReference type="KEGG" id="dvv:114326870"/>
    <dbReference type="CTD" id="54973"/>
    <dbReference type="InParanoid" id="A0A6P7F5W4"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="12">
        <location>
            <begin position="244"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028131124.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67276" checksum="1BCD3A633CEC28A7" modified="2020-12-02" version="1">MPEIKITPLGAGQDVGRSCLLLSMGGKNIMLDCGMHMGYNDERRFPDFTYICEGPISAFIDCVIISHFHLDHCGALPYMSEMVGYTGPIYMTHPTKAIAPILLEDMRKVSVEKKGDLNFFTSQMIKDCMKKVVAVTLHQSVMVDNEIEIKAYYAGHVLGAAMFWVRVGNQSIVYTGDYNMTPDRHLGAAWIDKCRPDLLISESTYATTIRDSKRCREKDFLKKVHECVDRGGKVLIPVFALGRAQELCILLETYWERMNLKAPIYFALGLTEKANNYYKMFITWTNQKIRKTFVQRNMFDFKHIKPFDRSFIDNPGPMVVFATPGMLHAGLSLHIFKKWAPNENNMIIMPGFCVQGTVGHKILNGAKKVEVENRQVIDVKMSVEYMSFSAHADAKGIMQLIQHCEPKNVMLVHGEAAKIEFLKEKIQQEFNIQCFNPANGETSVIQTSVKIPVDVSLPLLKAEAKRFSSMVPDPKRRRTLHGVLVMKDNGMCLMDVDEACKEAGINRHVVRFTSTVHIADTGPTLGTAHKLLLFIKDKLPICSVTFSEGEISVESVLVKVEGDDDDDQKSVYVSWTNQDEEIGSQILNIINHIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F788</accession>
    <name>A0A6P7F788_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114326518</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130712.1">
        <property type="nucleotide sequence ID" value="XM_028274911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F788"/>
    <dbReference type="FunCoup" id="A0A6P7F788">
        <property type="interactions" value="1295"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274911.2">
        <property type="protein sequence ID" value="XP_028130712.1"/>
        <property type="gene ID" value="LOC114326518"/>
    </dbReference>
    <dbReference type="GeneID" id="114326518"/>
    <dbReference type="KEGG" id="dvv:114326518"/>
    <dbReference type="InParanoid" id="A0A6P7F788"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028130712.1"/>
        </source>
    </evidence>
    <sequence length="64" mass="7473" checksum="86F51F42B5B89653" modified="2020-12-02" version="1">MYLMYYLKEDGTRVYTLKKTDPSGKPTLSAHPARFSPEDSYSKQRIIMKSRYNLLPTQQPAPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8T7</accession>
    <name>A0A6P7F8T7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoporin Nup37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327711</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132214.1">
        <property type="nucleotide sequence ID" value="XM_028276413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8T7"/>
    <dbReference type="FunCoup" id="A0A6P7F8T7">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276413.2">
        <property type="protein sequence ID" value="XP_028132214.1"/>
        <property type="gene ID" value="LOC114327711"/>
    </dbReference>
    <dbReference type="GeneID" id="114327711"/>
    <dbReference type="KEGG" id="dvv:114327711"/>
    <dbReference type="CTD" id="79023"/>
    <dbReference type="InParanoid" id="A0A6P7F8T7"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132214.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36110" checksum="4B4015C636C044E5" modified="2020-12-02" version="1">MIDLLDGNRKNLSEPFYTKNLAEHGQIVFIQFSPYEWSQDVFLIGFKKKILLAHLEITDVLSVRIITEFTHPVRCTALSISPDTSLAALPNKVIFCVGGNDFKLRVFNSDLGENSTCKVLSGHTSYINDCMYDPENTFLASTSDDNTVKIWSTDDYELKSTFSLTSPGMNVCWHRADSGKLLVAEKIGIIRFYNVETETSILSIDYNKPLSCAHWAPSERDVVASLQLGELLLWDLTKPCLPLQNNILFPENGGRIAFSPQAELVAAVNSLDSTLKVFHVRSQAVKLTAGLTLPTNVCWHYRYPLICVGDDFKLCFWKVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAD7</accession>
    <name>A0A6P7FAD7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GPI ethanolamine phosphate transferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114326400</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130563.1">
        <property type="nucleotide sequence ID" value="XM_028274762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAD7"/>
    <dbReference type="FunCoup" id="A0A6P7FAD7">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274762.2">
        <property type="protein sequence ID" value="XP_028130563.1"/>
        <property type="gene ID" value="LOC114326400"/>
    </dbReference>
    <dbReference type="GeneID" id="114326400"/>
    <dbReference type="KEGG" id="dvv:114326400"/>
    <dbReference type="CTD" id="35685"/>
    <dbReference type="InParanoid" id="A0A6P7FAD7"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="440"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="663"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028130563.1"/>
        </source>
    </evidence>
    <sequence length="824" mass="95152" checksum="98828E5FBF7AD0F1" modified="2020-12-02" version="1">MTTIYLLGMLSAFLFFYGFFPISTRTNVINNTPPSKINNVALKQHYFYNQSNFKKTVLIVIDALRLDFVNTKYMPLTTNLFQENGCSNEVKVETPTVTLPRIKALTVGNIPQFIDLVLNLASTESLSDSIIHSAHEHGKNIVFYGDDTWLKLFPNKFARHEGVSSFFVRDFTEVDLNVTRNVYAELKNDDWDIMILHYLGLDHIGHVYGPFSSLVPTKLNEMDNIIHTVFDNLSSKGEEVLLMVTGDHGMKDSGGHGGSTYSETHVPLVIIGHRCENTSLSQSDIPANLAVLMGVKIPSSSIGKVHRKLLQSNEDKYLYNLHYNSIILQQKGSCCHDLFEEASSHYIKYLNNNTDSISTSKAIKLYEKFLEKINDNLANSSVKQKETSLFIALCVIINIIIMIYSEILSKQNKYYLLFQKIVVLAIIIIQFNISEHLLVFSVMISILIILLFNNIYFLLPFNFHLTFSYLNFFVFISILHPLTFISSSYVEEEHQYWYFFNILFVLFNCVTVSKTKSKYDLLTTVVCLAMFRFLRTMNSTGDKWAMYPDLSGWLLKDENYFYYQLLFLVGLGSVLVAQYVLLLPKIPWNIHFISILTLCLIFIYKQQETSVILGRIAWFLVLVQLIMTYKLSKVIPWILIATLLLKPYNVILIPYCVLCSLYFSKHLSSTQDTVLYHTVLANMLYFAQGHSNSLASVDVSVGYTGLSEYQPIIVIAQVLCHIQAFPVLCHLLIFNNKQIQQREVWKVLFCNKLYVYLVTCIVTFLFRHHLFIWSVFAPKLFIEFVHLLFLCIEYLLVQVCVYIRRIHFLIQVTKIVFFKKYIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAK1</accession>
    <name>A0A6P7FAK1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114328038</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132581.1">
        <property type="nucleotide sequence ID" value="XM_028276780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAK1"/>
    <dbReference type="FunCoup" id="A0A6P7FAK1">
        <property type="interactions" value="707"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276780.2">
        <property type="protein sequence ID" value="XP_028132581.1"/>
        <property type="gene ID" value="LOC114328038"/>
    </dbReference>
    <dbReference type="GeneID" id="114328038"/>
    <dbReference type="KEGG" id="dvv:114328038"/>
    <dbReference type="CTD" id="39415"/>
    <dbReference type="InParanoid" id="A0A6P7FAK1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000028">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000003">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="194"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="286"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="382"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028132581.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53759" checksum="B319751F91BA69FD" modified="2020-12-02" version="1">MQSNNQEESTPDTSSPNLHELPPEDEERFERLFNTLDKNGNGRIDIHDLSEALREHGVHHGYAEKFLKSTKSVSGELSLADFIYYVREHEKNLRLHFSHLDKNKDGKIDLDELIKAFSDLGIPLERGEAKNLLQRMDQDGSLNISYDEWRDFLLLAPSSNIRDLITYWRHSTYLDIGEDMNVPDDFTQKEMQTGMWWRHLAAGGVAGAVSRTCTAPLDRLKVFLQVNPSREKIAVCFNNMLKEGGIKGLWRGNGINVLKIAPESAIKFAAYEQVKRLIKGDSQHALSIYERFCAGALAGGISQTAIYPLEVLKTRLALRKTGQYKSIADAAYKIYITEGSRSFYRGYIPNILGIIPYAGIDLAVYETLKKKYFMTHSSNEQPSFWMLLACGSASSTLGQMCSYPLALVRTRLQAQVNHPSSDPAGATMTGVFRTILEREGVCGLYRGITPNFIKVMPAVSISYVVYEYSSRLLGVNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH65</accession>
    <name>A0A6P7FH65_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Cyclin-G-associated kinase</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">DnaJ homolog subfamily C member 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LOC114330153</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="32">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028135271.1">
        <property type="nucleotide sequence ID" value="XM_028279470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH65"/>
    <dbReference type="FunCoup" id="A0A6P7FH65">
        <property type="interactions" value="1143"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643729.1">
        <property type="protein sequence ID" value="XP_050499686.1"/>
        <property type="gene ID" value="LOC126880070"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FH65"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14511">
        <property type="entry name" value="PTP_auxilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000228">
        <property type="entry name" value="cyclin-G-associated kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000001">
        <property type="entry name" value="cyclin-G-associated kinase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF105">
        <property type="entry name" value="CYCLIN-G-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="15" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 32" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="36"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="28">
        <location>
            <begin position="430"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="29">
        <location>
            <begin position="608"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="27">
        <location>
            <begin position="1109"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="776"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="931"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_028135271.1"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131712" checksum="A84807416E60FA04" modified="2020-12-02" version="1">MSELFKSAFEYFSGPTNGQIENSFVGQTIEISNVQLKIKKVIAEGGFAVVFVAQDVTTGKDYALKRLLAADEESKNNIIREINILKKVSGHPNIIQYLTASFIDKSQTQHGQSEFLLVTELCPGGSLVEVLQARTSAFDVDLITRIFYQTCRAVAHMHSQNPPIIHRDLKIENLLISAESSLKLCDFGSATTEVYRPDISWTANQHAGLEENMAKFTTPMYRAPEMVDTWNNYFVGTPVDTWALGCILYTLCFMRHPFEDSAKLRIMNANYNIPPDPKFSCFHEIIRGCLQANPQERITVSDILERLAAIAESNGYDLKAPLILSTPQHKSSEPQSQSTFYDGPSNNATKVPPSRPAPPTVDAPRPPPQQAPPRPTPPPQRHSPPQQQQQQQQQRPMEAKQSGLFSSIKGGAGSFLKNLKDTSSKVMATVQQSMARTDLDIHYISSRIIVMPYPSEGFESTYKTNHIEDVRLFLDSRHPNFKYSVYNLSRKPYHSKFGQARIVDCSFAYPETFRAPLLNSMYQLCEDIYQYLAGDSRNVVVIHCTDGKATSATLVCALLIYSGLFQVPEDALQMFAVKRCPPNMRPSELRYLYYLADIVRDPPLFPHYNPVTLVSIQMQPVPLFTKIRDGCRPYVEVYSENRCILSTLQDYERMRLFNIAEGKCFLPINATVCGDVSVIVYHARNILGGVMTQGKATGIKIFQIQLHTGYIPEEDTCIKYMKSDLDDLAEGQDHFQDRFTVSLNVFVTDTERKPSQPAPWQTDQTKRMVDTMFTSQIEKDETVDNFVSTPAPANKPEMPPKRPPERPVRPPPPPTSILQDTEDSSSDVEQAPPPPPKPSQPEPLIEAVDLLNLNSSSNAEPPAAKLSPSPSSNFDLLSQLGGDSGNEDFASFNSAPINKPNTNGNGSNMFDPFASLGGAGDGNNLLGGWSNFTAPTPTPAQNATPQNHAKEQKSTDPFADFGNLGGGLNFGSTIPPSTTPTSGSQTPNKVPPTTPQHMPSSNTATPKHQARSPLGGADYNRAHFDTLNKNQQQQQQPQNEPKEKVKSDDVFGDLLGSQGYSFTGKKDNAPRTMNAMMKKEMAAYMDPEKMKVMEWQEGKKNNIRALLCSMHTILWEGAKWNKCEMHTLVSPADVKKAYRKACLAVHPDKQTGTDNENLAKLIFMELNNAWSDFENDATQQNMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI41</accession>
    <name>A0A6P7FI41_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114329653</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028134632.1">
        <property type="nucleotide sequence ID" value="XM_028278831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI41"/>
    <dbReference type="FunCoup" id="A0A6P7FI41">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278831.2">
        <property type="protein sequence ID" value="XP_028134632.1"/>
        <property type="gene ID" value="LOC114329653"/>
    </dbReference>
    <dbReference type="GeneID" id="114329653"/>
    <dbReference type="KEGG" id="dvv:114329653"/>
    <dbReference type="InParanoid" id="A0A6P7FI41"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000107">
        <property type="entry name" value="inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="16">
        <location>
            <begin position="299"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028134632.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="58187" checksum="55CC9967451398D7" modified="2020-12-02" version="1">MSVVVNSDKVKYTDNFIETKYTYQYNKARKNGDVIEVTPISEKLVLKTSRKIPKLGVMLVGWGGNNGSTFTAAVIANKLGLTWPTKKGIQEANWYGSLTQAATVSLGDDVFVPFSKLLPMVDPDDIVIGGWDISSANLAESMERAQVLEPVLQQQLKPHMQTLKPKPSVYIPEFIAANQKSRADHVIKGTRQEQLEHICHDIAEFKDANNLDKIIILWTANTECFSDVLDGVNDTAENIKIAIANNDSNISPSTLFAYAAIAKGCTYINGSPQNTFVPGIIDFAEKRGVFIAGDDFKSGQTKIKSVLVDFLVGAGIKPVSIVSYNHLGNNDGKNLSAPPQFRSKEISKSNVVDDMVNSNDILYQPGEKPDHVVVIKYVPYVGDCKRALDEYTSEIMMGGLNTLVIHNTCEDSLLATPIILDLIILGELFTRIKIKRENSSDDEYTSFHPVLSLLSYLCKAPLVPKGTPVVNALNKQRACIENVIKACIGLPPENNMTLEHKLPFLMTENSKLNGEPLPKRIKIQNGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJA4</accession>
    <name>A0A6P7FJA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114330928 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114330928</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136174.1">
        <property type="nucleotide sequence ID" value="XM_028280373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050641949.1">
        <property type="protein sequence ID" value="XP_050497906.1"/>
        <property type="gene ID" value="LOC126879056"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FJA4"/>
    <dbReference type="OrthoDB" id="6726762at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028136174.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15441" checksum="21A4A80B479BCBB3" modified="2020-12-02" version="1">MNSFFREEANLETHPETVHSLECYNCNSTNAVDKPDACKGLESLTKCTDPALCLSATVIIEDGPVKKYSSIKQCHIPQNGQECENFLKNLKNMYPSSKVELFNNQCKTCDKTGCNKSGASTTMPILFTLLVSYVLCKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKI1</accession>
    <name>A0A6P7FKI1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114331205</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136501.1">
        <property type="nucleotide sequence ID" value="XM_028280700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKI1"/>
    <dbReference type="FunCoup" id="A0A6P7FKI1">
        <property type="interactions" value="1895"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280700.2">
        <property type="protein sequence ID" value="XP_028136501.1"/>
        <property type="gene ID" value="LOC114331205"/>
    </dbReference>
    <dbReference type="GeneID" id="114331205"/>
    <dbReference type="KEGG" id="dvv:114331205"/>
    <dbReference type="CTD" id="33105"/>
    <dbReference type="InParanoid" id="A0A6P7FKI1"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 16" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028136501.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45506" checksum="8C2592F7590429D4" modified="2020-12-02" version="1">MTVINKMEVDGGPKGEGFRSYYITKIEELQLIVAEKSQNLRRLQAQRNELNAKVRMLREELMLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDIDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQM8</accession>
    <name>A0A6P7FQM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114330174</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. It is associated with the U3, U8 and U13 small nuclear RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135298.1">
        <property type="nucleotide sequence ID" value="XM_028279497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQM8"/>
    <dbReference type="FunCoup" id="A0A6P7FQM8">
        <property type="interactions" value="1284"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279497.2">
        <property type="protein sequence ID" value="XP_028135298.1"/>
        <property type="gene ID" value="LOC114330174"/>
    </dbReference>
    <dbReference type="GeneID" id="114330174"/>
    <dbReference type="KEGG" id="dvv:114330174"/>
    <dbReference type="CTD" id="37662"/>
    <dbReference type="InParanoid" id="A0A6P7FQM8"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028135298.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="35005" checksum="E8D8FB2A08628B21" modified="2020-12-02" version="1">MGKPDFSPGGGRGGRGGFGGGRGGGGGFGGGRGGGGGRGGFGGGGRGGGGGRGGFGGGRGGGGRGGFGGRGGGDRGGGGRGGFGGRGGGGRGGGRGRGGGGGGFKGGKTVVIEPHRHEGVFIARGKEDALVTLNLVPGSEVYGEKRISVENEGEKTEYRVWNPFRSKLAAAILGGVDQIHMPPGSKVLYLGAASGTTVSHVSDVVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDTIFADVAQPDQARIVALNAQYFLKNNGHFVISIKASCIDSTAQPEAVFASEVKKLQADKLKPQEQLTLEPYERDHAVVVGVFRPPPKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRH2</accession>
    <name>A0A6P7FRH2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114333214</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138871.1">
        <property type="nucleotide sequence ID" value="XM_028283070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRH2"/>
    <dbReference type="FunCoup" id="A0A6P7FRH2">
        <property type="interactions" value="2013"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283070.2">
        <property type="protein sequence ID" value="XP_028138871.1"/>
        <property type="gene ID" value="LOC114333214"/>
    </dbReference>
    <dbReference type="GeneID" id="114333214"/>
    <dbReference type="KEGG" id="dvv:114333214"/>
    <dbReference type="InParanoid" id="A0A6P7FRH2"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028138871.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31310" checksum="B3E7C1095466F131" modified="2020-12-02" version="1">MRYAQLVIGPAGSGKSTYCSALAQHGVDTRRNIDVVNLDPAAEHFNYQPIVDIRELIHLQDAMDDEELQCGPNGGLVFCMEYLTENLDWLEEKLGDQEDDYILFDCPGQIELYTHLTAIKNLVKKLQMWRFNVCAVFLVDVQFITDGAKFISGTMAALSVMVNLEVPHVNILSKMDLLSKSAKKRLDSFLEPDSHFILGDIETCGNSAFNTKHRKLTEAIARLIEDYSLVKFIPLNLKNLESINDVLITIDNVIQYGEDQDIRTKDFEEKEEDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FT28</accession>
    <name>A0A6P7FT28_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosome transmission fidelity protein 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114333710</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139461.1">
        <property type="nucleotide sequence ID" value="XM_028283660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FT28"/>
    <dbReference type="FunCoup" id="A0A6P7FT28">
        <property type="interactions" value="1610"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283660.1">
        <property type="protein sequence ID" value="XP_028139461.1"/>
        <property type="gene ID" value="LOC114333710"/>
    </dbReference>
    <dbReference type="GeneID" id="114333710"/>
    <dbReference type="KEGG" id="dvv:114333710"/>
    <dbReference type="InParanoid" id="A0A6P7FT28"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028139461.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12681" checksum="00B4435A0AE26CF8" modified="2020-12-02" version="1">MPVLIKASKSDQTDECAIIELQGDLKSHSDSSFEDQFIGDLHYTKSGIPLLIIGHHLLYGKVAKMEKPFALMEKQEKDGKTCFVVKAIIRNKIIFKTRPKPIVGESCMEGDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTM4</accession>
    <name>A0A6P7FTM4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein AATF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114330886</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136110.1">
        <property type="nucleotide sequence ID" value="XM_028280309.1"/>
    </dbReference>
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        <property type="interactions" value="1922"/>
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    <dbReference type="EnsemblMetazoa" id="XM_028280309.2">
        <property type="protein sequence ID" value="XP_028136110.1"/>
        <property type="gene ID" value="LOC114330886"/>
    </dbReference>
    <dbReference type="GeneID" id="114330886"/>
    <dbReference type="KEGG" id="dvv:114330886"/>
    <dbReference type="InParanoid" id="A0A6P7FTM4"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AATF"/>
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        <property type="entry name" value="AATF/Bfr2"/>
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    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="162"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="3">
        <location>
            <begin position="394"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
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        <source>
            <dbReference type="Pfam" id="PF13339"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136110.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028136110.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55844" checksum="FCF1CA814EBC1736" modified="2020-12-02" version="1">MNKKTLADKISSLLTTTPDELDPEDNYEDDTTAKLNTEYPQEHGEETNQGSKFRKDNIDLLADVDERYAGKKGSRRHLNPDNDSSEFSESDNDVEDAESDNSNEGQDELEDDENDSNESEKSNSDDESIDSDQEYDDNSDNPELEDTSNFETLKTTDVSTQAKKGLCVKNQMHIWESLLEMRIQVQKCLLTANKMPNYEKYKEIKKESGQDFSTTVEKTKNTVSTLLDKFLCLQDLMWKKYPETKKLVSSNKKAESDDPDDEEIPSDTEDEADADLSDDENEESPKKRLKIADFGNHLQQKHNLYKDYRNSVIKKWHEKTRMPVLKNTTSNHSIIQHIEHSLGDKDKLIKRTRLKRSDYKIIGEDSASDIEEDSKQEKSSEEYNSEIFDDDDFYHQLLRELIEFKSSSLTDPVQLGRQWVQLQNLRSKMKRKIDTKATKGRKIRYAVHTKLVNFMAPIDDNLWTDEAKTELFGSVFGKTQTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWC8</accession>
    <name>A0A6P7FWC8_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114331531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114331531</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136925.1">
        <property type="nucleotide sequence ID" value="XM_028281124.1"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="XM_028281124.1">
        <property type="protein sequence ID" value="XP_028136925.1"/>
        <property type="gene ID" value="LOC114331531"/>
    </dbReference>
    <dbReference type="GeneID" id="114331531"/>
    <dbReference type="KEGG" id="dvv:114331531"/>
    <dbReference type="InParanoid" id="A0A6P7FWC8"/>
    <dbReference type="OrthoDB" id="6628848at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028136925.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20380" checksum="3DE5F1C3B0167A72" modified="2020-12-02" version="1">MMDSTSANNSALVFQRFASTILKFGSCKWKTNLHYNITSDATKFNYIVANLETVYISEVRDIIVSPPATERYVKLKSELIKRLSESQQQTIKRLLEHEELGDRQPSQFLHLQSLAGTTVPDNIVRSLRLGRLPSSTQAILATQAKASLDAVAELANTISESIAPSVHMSEVSNARESTIDKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX32</accession>
    <name>A0A6P7FX32_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114333632</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139362.1">
        <property type="nucleotide sequence ID" value="XM_028283561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX32"/>
    <dbReference type="FunCoup" id="A0A6P7FX32">
        <property type="interactions" value="2253"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283561.2">
        <property type="protein sequence ID" value="XP_028139362.1"/>
        <property type="gene ID" value="LOC114333632"/>
    </dbReference>
    <dbReference type="GeneID" id="114333632"/>
    <dbReference type="KEGG" id="dvv:114333632"/>
    <dbReference type="InParanoid" id="A0A6P7FX32"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902532">
        <property type="term" value="P:negative regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000019">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000023">
        <property type="entry name" value="cullin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000001">
        <property type="entry name" value="Putative Cullin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="430"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028139362.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="90340" checksum="7F0564E631708A34" modified="2020-12-02" version="1">MCDDISSNSKEMSSKSSLSNNTSVLKQFDLDQIWGDLHAGIQQVYNRETMHKSRYIQLYTHVYNYCTSVHQQNNGRASANANTKGKKNQIGGGAQLVGLELYKRLRDFLRNYLVTLLSDGLHRMDEDVLKFYTNQWEDYQFCSKVLDGVCAYLNRHWVKRECEEGRKGIYEIYQLALVTWRDHLFKQLNKAVTNAVLKLIEKERNGETINTRLVSGVINCYVELGLNEEEPGAKGPNLSVYKDSFENVFLEDTERFYMRESTSFLSENPVTEYMKRAEQRLAEEQKRVQNYLHITTSERLAGTCERVLIQKHLELFHSEFQQLLDDDKDADLGRMYSLVARIPDGLGELKTLLEQHIAAQGLAAIEKCGESAVNDPKVYVNTILEVHKKYNALVLVAFSNDSGFVAALDKACGRFINANAVTKQANSSSRSPELLAKYCDLLLKKSNKNAEEAELEDTLNQVMVVFKYIEDKDVFQKFYSKMLAKRLVQHMSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFRNHLLKSNESLGIDFTIQVLSSGSWPFQQSFTFGLPSELERSVHRFTNFYSGQHSGRKLNWLYNMSKGELNTNCFKNRYTLQASTFQMAVLLQYNVADSWTIAQLEENTQIKNDFLIQVVQILLKAKLLNCDDDENELGLNSMVTLNLGFKNKKLRVNINIPMKTELKLEQETTHKHIEEDRKLLIQAAIVRIMKTRKVLKHQQLVAEVLNQLSSRFKPRVHIIKKCIDILIEKEYLERTDGQKDTYSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX63</accession>
    <name>A0A6P7FX63_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Protein dpy-30 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC114331738</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137169.1">
        <property type="nucleotide sequence ID" value="XM_028281368.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028137170.1">
        <property type="nucleotide sequence ID" value="XM_028281369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX63"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648145.1">
        <property type="protein sequence ID" value="XP_050504102.1"/>
        <property type="gene ID" value="LOC126882995"/>
    </dbReference>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000003">
        <property type="entry name" value="protein dpy-30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028137169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028137170.1"/>
        </source>
    </evidence>
    <sequence length="81" mass="9113" checksum="FA58EDFC8604F553" modified="2020-12-02" version="1">MDNSEVMKKSRVDLSSLPTRQYLDQTVVPILMNALSYLAKERPDDPIAALASFLMKNKSTYESNSDNSPSNTEMTNVEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXQ8</accession>
    <name>A0A6P7FXQ8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromobox protein homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114332115</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137648.1">
        <property type="nucleotide sequence ID" value="XM_028281847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXQ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281847.2">
        <property type="protein sequence ID" value="XP_028137648.1"/>
        <property type="gene ID" value="LOC114332115"/>
    </dbReference>
    <dbReference type="GeneID" id="114332115"/>
    <dbReference type="KEGG" id="dvv:114332115"/>
    <dbReference type="InParanoid" id="A0A6P7FXQ8"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd18631">
        <property type="entry name" value="CD_HP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028137648.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19718" checksum="AD9D1752FD88BCEE" modified="2020-12-02" version="1">MVKTRGKEDNPEVVVPVPTDTPAGTTEEFSVEKILDKRTRNGKIEYLLKWKGYNEEDNTWEPEENLDCPDLIAAYEAQFELASTVDDPEKSKRKNITEDNRARGFDRGLEPHRIVGATDASGELMFLMMWKNCKEADLVPANQVNARCPEIVISYYENKKQWYSKSAVIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G237</accession>
    <name>A0A6P7G237_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114335109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114335109</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM193 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141077.1">
        <property type="nucleotide sequence ID" value="XM_028285276.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285276.2">
        <property type="protein sequence ID" value="XP_028141077.1"/>
        <property type="gene ID" value="LOC114335109"/>
    </dbReference>
    <dbReference type="GeneID" id="114335109"/>
    <dbReference type="KEGG" id="dvv:114335109"/>
    <dbReference type="InParanoid" id="A0A6P7G237"/>
    <dbReference type="OrthoDB" id="10044608at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029717">
        <property type="entry name" value="FAM193"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031802">
        <property type="entry name" value="FAM193_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109">
        <property type="entry name" value="AGAP004327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109:SF4">
        <property type="entry name" value="FAM193 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15914">
        <property type="entry name" value="FAM193_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM193 C-terminal" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141077.1"/>
        </source>
    </evidence>
    <sequence length="1300" mass="146809" checksum="05277E363B5ED1BB" modified="2020-12-02" version="1">MSKFSSFIELLVKQTCRRASHEFELESKQQSAPQVVRAVQDDVGIYSLEFLKALHDNTRDSLYKLIRTKDPNDPNSVEVPVGLNWLNNKDFTAPERKALLNFLYKVKDMAPSNSKNWIDLHHFTHYVYRNFASVSPDPTAEYLTPYFLDEMRGLVRSLIQEDKSQLYLRVLALLREYCIFAQWNYTKQEGEDHLITKLFYYYEAMLTAAKNLSDVFADIEVIIYSNYSICWIDFNTCVFIRYFLETDYVQQKIKQVLKTRVSPGDTPAMFALLEDLQKLWTREQNRIKKINDDLSLVEGTAAYYIEEAMISNHKKVLTTNFWMERTEQEKSDLDLRRLDHHLFRLLGDPYFHPAGPILDRNGQCICEECLVAKYDVMIHAVEEQSENKLLRSTSRLTFCRRCRTLLELDSFHRHVTDHAAADEVKAIIKDNTTKVGGALVLCEEPPEVSQRIPMPKEAADAALMTTCDIHFSRPKHDPNDLTCTRLAFEEFLKQSKDSTKHDALSNKNARRDFIKIKKDIFSNTGKVVFDDSILNPNTFASNLTPSVSPTKKKAEPSPKPKEIPKTSRKTERTRITSIKPPPKPSAYIPYDHLCKHVNEAAVCQGHSGMCDHQKEAKKCDCTYCEVFGTALSSHTHKNSELRDRLRNRLHQRREKRTKDTGKNPPLEANSAKIKTVISKVEERVPLPSSPTNIPPPAPTIRTTDSSGSSSASGSSASSPTSGSDDIHGLVSYIEGNLALTKMELAQKKAAKKARQRQKKEEERIKAEEEQKRREEENKIKEAEKKKELARKQAEREKSKAEAEAAAAQALKELKKKSKKERQAEKKRLLQQQKLEEEERKKIVEETIPAMVTIKRVAENGSSPTVTITLQGSTPEEEKLIYTLVKGDDDNVSEAAVAQEPNKGSKKKNKQKQPVQKPKPPDEIPQVVTKELKVTVGLGMNKQQNSESASTESGKFSNIKQLVESKKGTKLNDKKQNVSQDDMPIPMFRLPPGITITKIDGPVSIKNFQAANAEEQKGSSLNATKSGVIVVDTEKLIHKKQNNEATNGKPVSKTSKKKKKKNNAANKKAQDAKPTNASTEVKKMVTLKNPIFHPFQQQNPEPSLDKNAESCGPAAIFTNENGMVTIRSSRLQQSLSNGGSAGSVPLTTISNFAPEMQKSPIPSTVFTNSQMQDTKSDTMCPFYAQEILSGLPGIEITKVDKKTVKSEPEEYKSCQTAQVSIIPASTNGGEAFNFDNLDKDDWLFDSVFSPRDVLEDNMDPEELELEAFKRFCSQSIPPKRKEKVAHLNVADIVVKKKTNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4A5</accession>
    <name>A0A6P7G4A5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Perlucin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114335755</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141852.1">
        <property type="nucleotide sequence ID" value="XM_028286051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4A5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286051.2">
        <property type="protein sequence ID" value="XP_028141852.1"/>
        <property type="gene ID" value="LOC114335755"/>
    </dbReference>
    <dbReference type="GeneID" id="114335755"/>
    <dbReference type="KEGG" id="dvv:114335755"/>
    <dbReference type="InParanoid" id="A0A6P7G4A5"/>
    <dbReference type="OrthoDB" id="6338838at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028110967" evidence="2">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="45"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028141852.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21476" checksum="36A07038D396B189" modified="2020-12-02" version="1">MALFNLKSVILFTLVGSTLVTSRKVPNWEEVFRDYQSKVVPLRHWGNKSYWMGTSFQATWFEALTFCSQMHMQLLTINSEEENSVIYRYIREASKGFEYWTSGTRLIDGNKWVWFPYGDLIEYTRWSNGQPSDPNGEKCLQVWKVDDNWGLQWNDRPCDVRFHFICERYDSQNQGRGQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4U3</accession>
    <name>A0A6P7G4U3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114337738</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114337738</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144064.1">
        <property type="nucleotide sequence ID" value="XM_028288263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4U3"/>
    <dbReference type="FunCoup" id="A0A6P7G4U3">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288263.2">
        <property type="protein sequence ID" value="XP_028144064.1"/>
        <property type="gene ID" value="LOC114337738"/>
    </dbReference>
    <dbReference type="GeneID" id="114337738"/>
    <dbReference type="KEGG" id="dvv:114337738"/>
    <dbReference type="InParanoid" id="A0A6P7G4U3"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000004">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432:SF20">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21432">
        <property type="entry name" value="ACETYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="4">
        <location>
            <begin position="311"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144064.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="51112" checksum="942C2588DBCFC28C" modified="2020-12-02" version="1">MAVSVRGFSHRIGHLSSVLATVKSSPRTYFTYTNEPSQPIKGKEPKWCTPEEAFQDLQSGQTVFSQGAAATPIDCLNAMTKVGKSKNLKDITVCHMHTEGPAAYTDPSCEGIFRSCSFFMGGNVRKAVADGRGDAIPIFLSEIPLLFTRQIVKPDIAVIQVSPPDQHGYCSLGTSVDCVRAGMSHSKIIVAQINPRMPRTFGDGIIHISHIDYAVKVDTPLPCHGGKPPSDVETQIGKNIAENLVEDGATLQMGIGSIPDAVLACLTNHKDLGIHSEMFAGGVIDLVNRGCVTNNKKSIHRGRIVGSFLIGTQDLYDFVDNNPFIEMLVVDYVNSTSIIARQPKMTAINSCIEVDLTGQICSDSIGTRMYSGFGGQVDFIRGAAEGLDGKGKPIIALPSTTNKGESKIVPLLKSGAGVVTTKAHAHYVVTEHGIAFLFGKTLRQRAHALINIAHPNHREALEKAAFERLKVMPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7M5</accession>
    <name>A0A6P7G7M5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="12">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114334633</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="12"/>
    <dbReference type="RefSeq" id="XP_028140530.1">
        <property type="nucleotide sequence ID" value="XM_028284729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7M5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284729.2">
        <property type="protein sequence ID" value="XP_028140530.1"/>
        <property type="gene ID" value="LOC114334633"/>
    </dbReference>
    <dbReference type="GeneID" id="114334633"/>
    <dbReference type="KEGG" id="dvv:114334633"/>
    <dbReference type="CTD" id="32396"/>
    <dbReference type="OrthoDB" id="25346at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04414">
        <property type="entry name" value="NDPk6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028140530.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20844" checksum="EB0212AD172E7E9E" modified="2020-12-02" version="1">MTIASKLQLTLAIIKPHIVKNPISSQKIREIIISSNFKIVKSRRKIISLEEANTFYGEHKEKFFYKRLVSFMTSGPSDIMILAKENAIKDWRQLMGPTKVFKAQFEAPESIRGQFGLSDTRNASHGSDSEESARREIGIFFPSFDFDKWYQEDEPLFRSNKADLCLEQFLHLPVTRYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAC7</accession>
    <name>A0A6P7GAC7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 664-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114339739</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146211.1">
        <property type="nucleotide sequence ID" value="XM_028290410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050652401.1">
        <property type="protein sequence ID" value="XP_050508358.1"/>
        <property type="gene ID" value="LOC126885690"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GAC7"/>
    <dbReference type="OrthoDB" id="8300205at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000186">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001010">
        <property type="entry name" value="zinc finger protein 64 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028146211.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="57067" checksum="91B67BA52F2EF28B" modified="2020-12-02" version="1">MLAMEFKVEIEEHFVEYSQKDAEGQPTTSKDLENWKNEVKLENNSEMGLKAEIKEEFPEGCQEFNIESQLFTSSDLENLINKTDEDNSGISQDGMGVMKTELACTTEQQMSANIEETTLNNSICECKICFKQFDQEGSLKRHMKTHNKEKLYKCEICFKRFNQAHALKGHLRVHTGEKLYKCQICIKQFTRSDVLKVHLRVHTGETPYKCEICFKQFSQTAHLKTPLKVHTKQKPYKCEICFKQFTRKIFLDGHAKFHTGEKPYKCEICFKQFNEASDLKRHLRVHTGETPYKCEICFKQFSQTSHLKKHLMFHTGEKPYKCEICFKEFSRKDHLKTHLRVHTGETPYKCEICVKQFSNKSHLNTHLRLHTGETPYKCEICFKQFCHKIQLSTHLSVHTGEMPYECEICLKQFSQRSSLKKHLMFHTGEKPHKCKICFKQFSQIGHLRKHLMSHTREKSYKCEICFKQFTQRSNLKKHSKVHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGY6</accession>
    <name>A0A6P7GGY6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114342466</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149074.1">
        <property type="nucleotide sequence ID" value="XM_028293273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGY6"/>
    <dbReference type="FunCoup" id="A0A6P7GGY6">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647053.1">
        <property type="protein sequence ID" value="XP_050503010.1"/>
        <property type="gene ID" value="LOC126882232"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GGY6"/>
    <dbReference type="OrthoDB" id="1880105at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026686">
        <property type="entry name" value="UPF0708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14274">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14274:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14937">
        <property type="entry name" value="DUF4500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028149074.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12007" checksum="5B650EA2E0537627" modified="2020-12-02" version="1">MKKIGLCSKLLNLYIYYYYLNSSMSEKNPAPGDGLRSVRTTTLFRAVNFELYTKPNAVIMGIGLVAIAGCAGYIAYMRSKYEGMGYYGAVKEDGTEHFEKKSSKWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJD2</accession>
    <name>A0A6P7GJD2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Late secretory pathway protein AVL9 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114337597</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143880.1">
        <property type="nucleotide sequence ID" value="XM_028288079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJD2"/>
    <dbReference type="FunCoup" id="A0A6P7GJD2">
        <property type="interactions" value="1406"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288079.2">
        <property type="protein sequence ID" value="XP_028143880.1"/>
        <property type="gene ID" value="LOC114337597"/>
    </dbReference>
    <dbReference type="GeneID" id="114337597"/>
    <dbReference type="KEGG" id="dvv:114337597"/>
    <dbReference type="InParanoid" id="A0A6P7GJD2"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="9"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028143880.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="78480" checksum="38B190053126B157" modified="2020-12-02" version="1">MGEKDGPILYVLVIGFHHKRGCQVEYSFPELVPGHPNECPPGWKYLPTLALPDGSHNYDEDTVFFHLPSLTKPMQTVYGISCFRQIPVEKIKNKTSDITRGTVQKSVCVLSKVPLYGQIQVKMCLITHAYFDEGDFSQVSILKDTYHHLNAVMTQSDAIQQPFVGLSARDFILQWKHKALLLFKLLLLEKRVIFYKSPVHPLCSSILTLISLFPDMIETGLNNSACIRLSRPMSPMPEYSDEDSSPVKLNNIKNIPCLKGSRIKEETDVIQNVEIAKESKIVQDIEKNEKTNDVVNSNGNQIEDNLVNDNQTEVGLELTESMSQTKVCLEDEDEAINGHDGKTGTLHRDLSSDTISDVAHNNLTYLTHLSTESCGFPLAIFTKGALCLPYLSLPYLDLLVDVNVRSYVVGATNVLFKQKRQLYDILVDIDGNRIECQDLNLRKYLHLTTEDLRFADYIVKHVSEERHDVFLDGVGWEGGDEWIRTQFRVYLLCLLRTSMLQDGSREIDHFNSSFITAWRDSHNYKIWLSGINPGILDVHPGHPFAGQLSVADMKLRFSHTMQNTESGRKLNQAMASTGKAVVTTGKAVGGALSHAKGALSSWWSNFMVNPDQGQKALENQSQEESADTNNLTDSLTNIPSSINSDKENNKIETNQTEVNKSENESDIKNVSNGSVICNEKSRINHEMEDNHIPGEVHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL74</accession>
    <name>A0A6P7GL74_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114339514</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145978.1">
        <property type="nucleotide sequence ID" value="XM_028290177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL74"/>
    <dbReference type="EnsemblMetazoa" id="XM_028290177.2">
        <property type="protein sequence ID" value="XP_028145978.1"/>
        <property type="gene ID" value="LOC114339514"/>
    </dbReference>
    <dbReference type="GeneID" id="114339514"/>
    <dbReference type="KEGG" id="dvv:114339514"/>
    <dbReference type="InParanoid" id="A0A6P7GL74"/>
    <dbReference type="OrthoDB" id="6677701at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719:SF1">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028145978.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17683" checksum="5A01111DCE3188E0" modified="2020-12-02" version="1">MCFLDSVISQKLLSRLQVLIVLVVIVVEIFSVDSFKQTKNVCDDSGQFVIAEYDWTFRCAENKQLACGKPQRRAILLRTLLELNITTPTTPNMIIIYRCENSGCCVRAHEECTNTSSTKHRINFTTSSGLRRETTIYNHTACSCQYIRATQECFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMY5</accession>
    <name>A0A6P7GMY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114344367</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028151004.1">
        <property type="nucleotide sequence ID" value="XM_028295203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMY5"/>
    <dbReference type="FunCoup" id="A0A6P7GMY5">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295203.2">
        <property type="protein sequence ID" value="XP_028151004.1"/>
        <property type="gene ID" value="LOC114344367"/>
    </dbReference>
    <dbReference type="GeneID" id="114344367"/>
    <dbReference type="KEGG" id="dvv:114344367"/>
    <dbReference type="CTD" id="32080"/>
    <dbReference type="InParanoid" id="A0A6P7GMY5"/>
    <dbReference type="OrthoDB" id="1915767at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
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    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13196">
        <property type="entry name" value="FERM_C_JAK"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Band_41_domain"/>
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        <property type="entry name" value="FERM_2"/>
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        <property type="entry name" value="FERM_central"/>
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        <property type="entry name" value="FERM_domain"/>
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    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
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    <dbReference type="InterPro" id="IPR041381">
        <property type="entry name" value="JAK1-3/TYK2_PHL_dom"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="SH2"/>
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        <property type="entry name" value="SH2_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
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    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016251">
        <property type="entry name" value="Tyr_kinase_non-rcpt_Jak/Tyk2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF7">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Jak1_Phl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21990">
        <property type="entry name" value="SH2_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01823">
        <property type="entry name" value="JANUSKINASE"/>
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        <property type="entry name" value="TYRKINASE"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TyrKc"/>
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        <property type="entry name" value="Second domain of FERM"/>
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    <keyword evidence="7 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="18">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="321"/>
            <end position="422"/>
        </location>
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    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="468"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="845"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011903"/>
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            <dbReference type="ARBA" id="ARBA00023137"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028151004.1"/>
        </source>
    </evidence>
    <sequence length="1120" mass="128312" checksum="0AE6B6AE6ED7745B" modified="2020-12-02" version="1">MGDLHLNVNLVLDCKPISVPYTANKTTAEDICIYICKHLNIGNLTRHIFGLRLTGKNVFFMSAATFPEKHPPIDFRIRFKVANVFKLKKLDVNTYNYYFHQARNDVLENKIPDIIYEKCRRELVGLGITDMFRVMLEKDIPRETVESEYKKYIPKEVIKRHAFFIKKPIHDTLGKLQKSDHDASYVKSEYLKQLETLAPEYLSESYKAIVDQDGSICNIIIKVSPYHPTEPGVKYCLESKKDQWNLICTIEDIGFVSIRDDGTTEISRRNGIPFYLKFNTLSILYSFISLLDGYYRLTCKWTFNICKEVYTPSLQKLHFMKCHGPVGGEFSYAKLEEKRGNKAGCFIVRESESKYNDYYIDVCIKDNLKPKTFKLEKISGGELIFTNDLANDLTKYKSIQQLMSSYQDPNASIFLQECLPPSEYDISPLLLCRSETLVGDLLTDSSALNSINMPSLPVCINCKSLQVFKGQEKEGLSGITLVHRSMWKITKGKKIEVAMKLLKNDSDRYVKQFLSLAGQWAFLQSSSIVRLYGIAFTSDIALVLEYFRLGPLDQYLRTHRETVKQVDLIEAAGSIASALWHLTENNIVHGRIRCRKIMVSVHDENSFIVKLTDPGIHTEYTPSEVHWIPIECYTNLNYAKRSVEADVWAFATTLWEMFMYGEEIKPFKSNDHLQVMRWYASGKRLPQPLVCSSEIYSLMKECWDNDPHKRKKPQAIMRDINQILYQVYNSRRVHSYAKVFSKADSHSLSAYSVNSSNITESTILYNDLINGSNISSDMSDYNSLSDSTSQLKLINDDISFDNFDDSGPYEFSAIFSSLNLSTATTSLDSLNTMQTVFELDDNYNVVLQGRIGQGFYGDVFQGMLEFVDSQDGEPRKVAVKKLKASSVSSCLQDFEREINIMKSLKHPNIVEILGVLREPEISLVMEFVHHGSLQSYLKIHKESLSEVQLLKYALDIAKGMEYLGTKNIVHRDLAARNILVVDENHVKISDFGLAQVIGTNDYYIVKTPNRELPIKWYAPESLRDGKFSVRSDIWSYGVTMCELFNYGEEPMLAQMDEKMQAPLQQILLAALEKGSRFPPPPKCPATVYVRIIHPCWMADPHERPMFSTLIMEITDLMSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GN16</accession>
    <name>A0A6P7GN16_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114338774</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114338774</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145190.1">
        <property type="nucleotide sequence ID" value="XM_028289389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GN16"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289389.2">
        <property type="protein sequence ID" value="XP_028145190.1"/>
        <property type="gene ID" value="LOC114338774"/>
    </dbReference>
    <dbReference type="GeneID" id="114338774"/>
    <dbReference type="KEGG" id="dvv:114338774"/>
    <dbReference type="InParanoid" id="A0A6P7GN16"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027922329" evidence="3">
        <location>
            <begin position="17"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028145190.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="20946" checksum="DC494F538907CAB2" modified="2020-12-02" version="1">MLQIFLLFALFLHTHSKPTYCPMGSYFEHETDCTKFYQCAPWGAQLMNCSSGTVFDPEINVCSWRRPGLCGWTTTEITTNPKKSKSFNRDLTEAPVIEIPGKKPYISTNISDSNIRLKDKARLNKAGSVNQSTDTEESKASTGEPVVSTEEPAERSSSFSTLSDYRRFAIILAIITLFTAALNGLAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQK5</accession>
    <name>A0A6P7GQK5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIFamide-related peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147513.1">
        <property type="nucleotide sequence ID" value="XM_028291712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQK5"/>
    <dbReference type="FunCoup" id="A0A6P7GQK5">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291712.2">
        <property type="protein sequence ID" value="XP_028147513.1"/>
        <property type="gene ID" value="LOC114340937"/>
    </dbReference>
    <dbReference type="GeneID" id="114340937"/>
    <dbReference type="KEGG" id="dvv:114340937"/>
    <dbReference type="CTD" id="3346202"/>
    <dbReference type="InParanoid" id="A0A6P7GQK5"/>
    <dbReference type="OrthoDB" id="8190180at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139635" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147513.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="8464" checksum="4CA95823DFA8FB6D" modified="2020-12-02" version="1">MESHFQKTLTLFCVVIFLVFGVMSSTDAAYRRPPFNGSIFGKRTAGSNDFENAGKALSAMCEIASEACSSWFPTQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR33</accession>
    <name>A0A6P7GR33_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium-dependent nutrient amino acid transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114341116</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147698.1">
        <property type="nucleotide sequence ID" value="XM_028291897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR33"/>
    <dbReference type="FunCoup" id="A0A6P7GR33">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658672.1">
        <property type="protein sequence ID" value="XP_050514629.1"/>
        <property type="gene ID" value="LOC126889930"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GR33"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06857">
        <property type="entry name" value="SLC5-6-like_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028147698.1"/>
        </source>
    </evidence>
    <sequence length="803" mass="90837" checksum="B5E57D0F13EDC01C" modified="2020-12-02" version="1">MRGKWSNNQQLNGHSTIPRSADLENIKFKHLQHSPSLRAIKVYNDLPVEGNFQNDIDLRLYTPQKYDTNSMSRISVGSSKGYSDQHFYEYINGGGTMSIASGSMDLNGSETNEMGSTAKLVPPKIEQSCQTMMYYISTTLCTMSMALGLGNLYRLPQTTMIRGGLPFLIAHLILTIFIGLPLLFLELGIGQLAQEGFIKSWRVVPFFRGIGYVKFLAGYMLSIYYPLYMGISLYFVIWIAKGSIPLSECSSGVKITEDGYSHYGKDGQKCLRSTFLKSAFEDPYWFGIFASILFAIWAITALLTISKTKSFIRSLVLLIFPTLACLIALFVKSVMYESELIYFYTKADWSLLESANVWYYAAIQVFFSSTVGFGSFVTNAGIIYNKVNPFWTAIGYCTINIIFGIGSTIISQSLARHTNVNITANKDDIAELMLVSVIYDIGSASTATDKKVWIIVIFSLFILSGFITMATMTYTLLKAITVGSRARLSWWQASILLSASGFIFGCAILLKEDFDIVHLLDHYIVGNLILITAILEVLTLLAFYGVDRIRSDFEFMLGHILSHFWLILWWIAPLVLTGLFAWGMVTLPLEGIYKDDPIWLYGVGWGVVLTASLLIFVTGFYVVKKQDGYTFIERFKTSFRPSKNWGPKDPISRHNWVQWNSKAQSGERDFTLKRKGTKDYTKSIKRTKKLAVAEAFKEKEEKLEKQSTNTSNGTNIYSELNESNNIHKKPHRNERPPYRVVSLSDANFVQFNGRKNPLARREVVSMPVDEYGTFRKGPYVIEDEQVDHVCFRKISDHEDATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GT04</accession>
    <name>A0A6P7GT04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114346393</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028152946.1">
        <property type="nucleotide sequence ID" value="XM_028297145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GT04"/>
    <dbReference type="FunCoup" id="A0A6P7GT04">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657668.1">
        <property type="protein sequence ID" value="XP_050513625.1"/>
        <property type="gene ID" value="LOC126889410"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GT04"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF1">
        <property type="entry name" value="RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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        </source>
    </evidence>
    <sequence length="1341" mass="152103" checksum="F5B4344F7A1D4CDB" modified="2020-12-02" version="1">MEVMCNNFMPGDSRLVEQLVSELKSQGIFDQFRKECISDVDTKPAYQNLRQRVEGSVSTFLKGQTWSVELNKNQLREQLRKNLQESGFLETGVERIVDQVVNPKINSVFLPKVEEVVYKFLGLENPNKNMKREPEVPAPDPLPTDLEAVSPGSVQSDQVDLKKADSDVFMNAVEAGGKMEDDDPPPFEPHPVDSKENGSEKMNIDENTRDSHLSGFSGLESHESNLGSDNRVFHMEISNQDSQISHNSSESHLSIITSEETSKMDISEDSNTILKPEKAEVLVEDEENVSPEYEPIDKETIKLEKIDNKIDIVSQDDKNQDDEKTEKKPEKTEERRSKTNEKSSKDKKDDRKEDKKDDKKDNKKDDKHRKSSSSSSREKDKSSSKSHSSSKDKDRKDSRSSSSHKDKDKNKDKADKEKIDKDKDKSSKYREKSEKDKSKPDKERSDKDKSRSDKSKIEKENANKAEKEKSGKEKSDRSKDEKSKSKTDKYKSEKDRHKSDKDKSSSKDKDRSDKDKSSKDKDKYKDKSYKSKEKSDKEKEKSSTKEKSSSDRSSSKKDAKEKKDDNKESSKESKDKTKEENKEKDKSRSSSSSSKHTSSKDKKPSTPKKESSSSSHKKSSPSDPKSKSSSEKGKKDEGTNSNKKDKQESKAKSKDDHYSFKIKKSDRRSTDRDSNDGTSSKNVFNSYSESTTSRSGNNSQDYSSSSFTSGSGDSGNSDKTETVQKESNGPVEAPAPAKILLEMPRVKYIKPKFAMNFEEARKIMKIRKQLAMLERQNQLSLARLIPVQNSIVNGETNKDDNTSQTAASVNKEQTKTVDISEEKENINTSRAVDDTIIQAPVDNKSVNKVETVCVDASINLITEIESRDISKENWEALEAKLAQVMSEVDYNCYDSDEDFEFHGYSSIDIIPKNFFDVNRDLVKKTEEEISKNQKASKLLEASVQQSKLHNLKINSEEEQVPNIVNSSRNSNKNVQDSSPKKTEEEISKDQNASNLLEASVQQKSQLHNLDKINSEEEHVHNIVNSSPNSNKNVQNSPPKKTEEEICKHQHASNLLEVSVQQSERHNLNKINSEEEQVPNIVSSSTNSNKNVQDSPPKKTEEEISKDQNASNLLEASVQQTELNNIDKINSEKEQVPNIVNSNTNSNKNVQDSPPSSSEKTYTREILNANVKNTELLAALSDDKCYFLKEPSCDEESYLSGLKMLISRMEVDIEQCTENLRNNVWPSKRGRKRKLEVHVDIKNNNKTPYMETVKKRRGSASSLTVTPMAGKKRMSNSSDITPTEHFSLPLSPAESDKSNERKDEDLVIPIKQKRIMREYTQRYSSEDLYKPRPVFGRRRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H294</accession>
    <name>A0A6P7H294_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardioacceleratory peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114345196</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151818.1">
        <property type="nucleotide sequence ID" value="XM_028296017.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502386.1">
        <property type="nucleotide sequence ID" value="XM_050646429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H294"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646429.1">
        <property type="protein sequence ID" value="XP_050502386.1"/>
        <property type="gene ID" value="LOC114345196"/>
    </dbReference>
    <dbReference type="GeneID" id="114345196"/>
    <dbReference type="KEGG" id="dvv:114345196"/>
    <dbReference type="CTD" id="115874248"/>
    <dbReference type="InParanoid" id="A0A6P7H294"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000188">
        <property type="entry name" value="Neuropeptide S receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052665">
        <property type="entry name" value="Neuropeptide-GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24224:SF6">
        <property type="entry name" value="CARDIOACCELERATORY PEPTIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028151818.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="43893" checksum="C858FC168B3557D4" modified="2020-12-02" version="1">MASVKNEIINDSEPTNGTHINKFYFYEVEQFTVLWLLLIVIVAGNLGVIYTLTIGRSRKSRMNYFITHLACADLLVGLISVLTDLIWRTTVSWYAGNAACKIIKFLQVVVTYGSTYVLVALSIDRYDAIRHPMKFSGSWRRAKCLIIAAWLISVLFAIPILILYEEKLIQGQSQCWLSFSAQWMWKLYMTLVSVSLFCIPAIIITTCYAIIIVTIWTKSASTFHHFKSRANGERRESDNLRRASSRGLIPKAKVKTIKITFVIVSVFILCWSPYIIFDLLQVYEQIPQTQTNIAIATFVQSLAPLNSAANPIIYCIFSTHFCRSLWLFPPCKWISKKKKRKQKDSTLTTQSSSLSEYLTHNHKKRSEGVGTAVVRGHTVLIHTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H5W8</accession>
    <name>A0A6P7H5W8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114346534</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153108.1">
        <property type="nucleotide sequence ID" value="XM_028297307.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497934.1">
        <property type="nucleotide sequence ID" value="XM_050641977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H5W8"/>
    <dbReference type="FunCoup" id="A0A6P7H5W8">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641977.1">
        <property type="protein sequence ID" value="XP_050497934.1"/>
        <property type="gene ID" value="LOC114346534"/>
    </dbReference>
    <dbReference type="GeneID" id="114346534"/>
    <dbReference type="KEGG" id="dvv:114346534"/>
    <dbReference type="CTD" id="219927"/>
    <dbReference type="InParanoid" id="A0A6P7H5W8"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028153108.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22805" checksum="015D40200324C7C2" modified="2020-12-02" version="1">MALFLKRACSQVIRFSQLTNRNIVFKNIPAVSLVSSVHYSNKPTPYEVVNKDEEKSVTKEIISKVNNLVTNKSHGRLFAVVHVAGKQFKITDGDVIVIEGYWPPDVGDKITLDKVLLAGSADFTLIGRPIVEKGLVKVEATVIEKTLSHTKTHFRKKRRKQYMRIHFYRIPQTYLRINQISIEDEVNNPKEVRGLETAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HC92</accession>
    <name>A0A6P7HC92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114346824</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex. The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153395.1">
        <property type="nucleotide sequence ID" value="XM_028297594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HC92"/>
    <dbReference type="FunCoup" id="A0A6P7HC92">
        <property type="interactions" value="1092"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297594.2">
        <property type="protein sequence ID" value="XP_028153395.1"/>
        <property type="gene ID" value="LOC114346824"/>
    </dbReference>
    <dbReference type="GeneID" id="114346824"/>
    <dbReference type="KEGG" id="dvv:114346824"/>
    <dbReference type="CTD" id="43590"/>
    <dbReference type="InParanoid" id="A0A6P7HC92"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000004">
        <property type="entry name" value="Trafficking protein particle complex 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028153395.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16993" checksum="516DB81D51C127A8" modified="2020-12-02" version="1">MTIYNIYIFDKSGILLYYQEWNRVKQSGMTKEEEAKLMYGMLFSIKSFVSKISPTDPKEGFLFYKTSKYTLHFFETPSGLKFVLNTDTQSQGVREILQQLYSQIYVEYVIKNPLCRLSQPIDSDLFKTKLDAYIKQLSIYPSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICA9</accession>
    <name>A0ABM5ICA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129701.2">
        <property type="nucleotide sequence ID" value="XM_028273900.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273900.2">
        <property type="protein sequence ID" value="XP_028129701.2"/>
        <property type="gene ID" value="LOC114325766"/>
    </dbReference>
    <dbReference type="GeneID" id="114325766"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129701.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="454" mass="50944" checksum="8387628AC46F5612" modified="2025-10-08" version="1">MSEVMSEDCEKTPQYISAACISVGAFGMGTAIGWTSNITQDLKEGELNEIDMTDVEIAWIGAMMTLGAILMCIAVGWIVDMIGRKSTVLYSIFPFFIGWLLITCSSEITLTYIGRFLVGIAGGSFCVIVPLYTSEIAHESIRGALGTFFQLSITIGIFYCGVCGFTLPLIGFNISCCVIPLFFGAAFYFQPETPTFSLKQGHIEKAEEAFRRLRGESYDFSEEMKQILSNIEREQHFWKTFEKKSTKRALIICFMLMFYQQLSGINAIMFYSQEIFYISGSEMRDSHCVMLLQSIQVIATLLSTLTVDWFGRRILLLTSSGFMAFSTTMIGVYFSLKRTGILSEHTAFSFVPVMSLNIFIIAYSFGFGPIPWMIPSEMFTPEIKTKCSAMAATFNWTLAFLVTKFYFPISEGIGTDSSFYIFSFISATAIVFVYFVMPETRGKTFAQIQIELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IET7</accession>
    <name>A0ABM5IET7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131244.2">
        <property type="nucleotide sequence ID" value="XM_028275443.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275443.2">
        <property type="protein sequence ID" value="XP_028131244.2"/>
        <property type="gene ID" value="LOC114326933"/>
    </dbReference>
    <dbReference type="GeneID" id="114326933"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16227">
        <property type="entry name" value="EFh_CREC_RCN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF95">
        <property type="entry name" value="LD34388P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046221541" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131244.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="324" mass="37037" checksum="FABFEF749D305A81" modified="2025-10-08" version="1">MFRVLFYLFLIFANTINAGVMHSHTNEIHKERESDGAYSPRNHGHFSEEGEHYNEFDHEAILGSHKEAEMYDQLPPEEAKRRLAILLKKMDLNNDSQIERHELKAWIIRSFSMLSEEEAKDRLEDADENNDGQVTWEEYLADTYGLDSSENNIDIGGENEHLIESDRAMWKAADVNGDGILDENEWAPFSHPEEYPSMLPLILEQTLKEKDTDGDNGLIFQEFVGERGTHMSKEDLLTEKSKFDAFDSNGDGKLTGNEILSWVVPSNDEIADEEVDHLFASSDDTHDGVLSFSEILAHHDIFVGSEATDYGDHLHNIHHFDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKR4</accession>
    <name>A0ABM5IKR4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135097.2">
        <property type="nucleotide sequence ID" value="XM_028279296.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279296.2">
        <property type="protein sequence ID" value="XP_028135097.2"/>
        <property type="gene ID" value="LOC114330004"/>
    </dbReference>
    <dbReference type="GeneID" id="114330004"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051449">
        <property type="entry name" value="ABC-2_transporter_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30294">
        <property type="entry name" value="MEMBRANE COMPONENT OF ABC TRANSPORTER YHHJ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30294:SF38">
        <property type="entry name" value="TRANSPORT PERMEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="361" mass="41620" checksum="25117DDBFED6DEE0" modified="2025-10-08" version="1">MKNNHAIYEIIVVLVVIINLSVGTYTGPNKVAIVNKEQPYVNKTYQPCSYKPGCYFLNLTCSLLDKIAKNTEKEYYATPEDAQDALENGDIWAIFYFPRNFTDGLMSRVIHLAHASEQLLQESQMQVWIRGDYSNDLEDFQQSFKIFTMKLIRKCGSPNINLQNLGLLVSYKQVINPKLSKLAIINEDQIFVNKTYQPCHFEEDCTTNIQRFSNMSCKFLDTIKDETIEYYSTLEDGLNDLQKGDAWGAIHVKKGFSDAIVASLSLTYDPYYIQYGYINQIRIWIHPLRESTKIGLGEKDLQQRFTKVIENLLKTCRKKGNNIPEWMTELTNGFSTKDIKSIAAFQDFNNITSYVQYAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INT8</accession>
    <name>A0ABM5INT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein BRX1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137614.2">
        <property type="nucleotide sequence ID" value="XM_028281813.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281813.2">
        <property type="protein sequence ID" value="XP_028137614.2"/>
        <property type="gene ID" value="LOC114332099"/>
    </dbReference>
    <dbReference type="GeneID" id="114332099"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="8">
        <location>
            <begin position="42"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137614.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="395" mass="45193" checksum="F4B425DECD49D1AC" modified="2025-10-08" version="1">MGKVKKTKEKPGVAQEEASVVPPAVRQSDDPVDTKRKWINKQRVLVFASRGINHRDRHLMEDIKKLMPHHKPEAKMERSKTLSVINEMCEMKNCNKAVMFEGRKKRDLYLWLSNTPNGPSVKFLVQNVYTMEELKLTGNCLRGSRPILSFDPVFTEKPHYSLLKELLTQTFGVPRHHPKSQPFFDHVYTFTVLDNRIWFRNFQILSEDGALAEVGPRFVLNPVKIFSGSFGGVALWENASYMSPARYRNQVRIAAKNKYVNRIQQKVHAEATRPTESYKMRPLDDIFQGNPLDKAQEYKKQEVENEEAQTAIIKEVKNKKKKKLKGITKENGTNTGKTLLKKIKQNKKANDGNLVKTKKSSNSIVKAKNKINKGKKGKIGIKVKINGLAKKSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQA7</accession>
    <name>A0ABM5IQA7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138701.2">
        <property type="nucleotide sequence ID" value="XM_028282900.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282900.2">
        <property type="protein sequence ID" value="XP_028138701.2"/>
        <property type="gene ID" value="LOC114333076"/>
    </dbReference>
    <dbReference type="GeneID" id="114333076"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF143">
        <property type="entry name" value="SERINE PROTEASE GD-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046141283" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="277"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138701.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="459" mass="51885" checksum="3DDA7DBA2904B34D" modified="2025-10-08" version="1">MKYKYRLSFLLIWLPMILSRVPPNPCPDIFHYYKDDEGIIYGVVNLPYDDATSLIFSVNASFVGNPKQTKLRLERLTKVHELNDGTTEVTYNIYFPSNEVIPKITGITYNNIMYCSSYEPLGATRIVNVRYQHDSNFTRQEKGFYKPETEQDISEDNIPVKNPIEKPTTTPRVAKPTPDRVTPVPPQMLPPQHKLNESPTVLDPPNSFLKPSQDILPPVPNPTETDTDLIDEKFIDNLFTTPFTTPSSNSDFKCGKEQQKNEVLPFILGGTNTRIGHSHYPWLVALFSKMVHKCDYKCSATLISDKHVLTGRPVQFSNVLSPVCLWKGNTDLSPLVNKLGIITGLEQDNDTPEIGLTHRLREKRVEMTIISQSECLGTPLGFQDVTSDKTFCSKRRETVTGPCIGDVGAGFYIFMDGAYYLRGIASNVFDKYGTCALINRYAVFSDVAKFLDWIKSHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IS74</accession>
    <name>A0ABM5IS74_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgin-45</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140378.2">
        <property type="nucleotide sequence ID" value="XM_028284577.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284577.2">
        <property type="protein sequence ID" value="XP_028140378.2"/>
        <property type="gene ID" value="LOC114334515"/>
    </dbReference>
    <dbReference type="GeneID" id="114334515"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140378.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46534" checksum="06AB701AEC522901" modified="2025-10-08" version="1">MDKVVRTQGDGIDNSTFNMSHPLESIINPTNAAKRSKQILNSLRPVEPSSKVVYLTPKHKFSPKVAPNYFVQKQKEPKFVPCEPYKAAVEPLLCSKKVVNRSPKRVARNDMDLQNLVTQLSETRKLEMDKINATKEVDEIDHVKLLLQWKKEKEQYEIDLQNLRSSNNLLENQLKFQAQVNSELKTLLVAAVGEDLENRVQHLTEDKLSLARALLNSANHLTSHQEHTEWLSGQCEVWRSKFLASSLMVEELAKWKSAFSNRTNELQEVTKMLLDERKKIHSQLLDLLSQLNSINKHVFKETHQQPVLTYGTVLEVTHIDLELARKLRDYLKLGDMDDKNIFSAAGVQPTLAEKKAQRLLNNPVAISNKPDALCSAVIGAASSVSSEQMFLQYPSVHPCCSHCKGEIQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ITM7</accession>
    <name>A0ABM5ITM7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028141564.2">
        <property type="nucleotide sequence ID" value="XM_028285763.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285763.2">
        <property type="protein sequence ID" value="XP_028141564.2"/>
        <property type="gene ID" value="LOC114335512"/>
    </dbReference>
    <dbReference type="GeneID" id="114335512"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14126">
        <property type="entry name" value="STKc_CK1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022247">
        <property type="entry name" value="Casein_kinase-1_gamma_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12605">
        <property type="entry name" value="CK1gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="38"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141564.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="432" mass="49401" checksum="0562790BB312A525" modified="2025-10-08" version="1">MEKDQKQKNSKRHNATDAHSNRHNVNSSSGVLMVGPNYRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGTHDGVPDVYYFGPCGKYNALVMELLGPSLEDLFDMCDRKFSLKTVLMIAIQLLHRIEYVHSRHLIYRDIKPENFLIGRSSTNKEKVIHIIDFGLAKEYIELETNKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIFVLCDGHPEEMAAYLRYVRQLDFFETPDYEYLRELFIKLFNKKGYTDDGEFDWSGKTMSTPVSALQTNAHEGLISDKPLSPKRIAFYGGWQNPSKQSALGNLTPADRHGSVQVVSSTNGELNTDDPTAGHSNAPITQPVEVEIVDETKCCGFFKRKKKKSVRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUH4</accession>
    <name>A0ABM5IUH4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142461.2">
        <property type="nucleotide sequence ID" value="XM_028286660.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286660.2">
        <property type="protein sequence ID" value="XP_028142461.2"/>
        <property type="gene ID" value="LOC114336318"/>
    </dbReference>
    <dbReference type="GeneID" id="114336318"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142461.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="440" mass="52704" checksum="B53BC1A588E8D6AA" modified="2025-10-08" version="1">MDVKVEVKEELEEYDQRYVASQLSTEVHLPEFKDEPDKYSLQIGNKNDSEEEHGMKIMKIPSPHKEEEYISRQSEEKIQIAQGSYQCKPCDFKSQKKVDTGERDNKRDICLKQFTQKCTLNKHIKVHIGERHHKCEICFKQFTLKSTFNNHMIVHTKERPYKCEICFKQFSWKFCLNNHLKDHIGERDYECDICLKQFAQKSTLNIHMRVHTGERPFKCDICLKQFTQKCTLDDHTKVHTGERHHKCEICFKQFTQKSTFNNHMIVHTAERPYKCEVCFKQFSQKFSLNNHMKDHTGEKPHKCDICLKQFTQKFTFNEHMRVHTGERPYKCEICFKQFSWKFSLNTHMKVHTGERPFKCEICHKQFTQKNNLNIHMNVHTGERPFKCEICLKQFTQKNNLDIHMKVHTGERSYKCEICLKQFTQQVTLRRHTKVHTGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWT7</accession>
    <name>A0ABM5IWT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145855.2">
        <property type="nucleotide sequence ID" value="XM_028290054.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290054.2">
        <property type="protein sequence ID" value="XP_028145855.2"/>
        <property type="gene ID" value="LOC114339404"/>
    </dbReference>
    <dbReference type="GeneID" id="114339404"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="510"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1380"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1514"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1581"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1650"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1717"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1785"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145855.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1847" mass="209067" checksum="D83B2806AB59BBFC" modified="2025-10-08" version="1">MVMDSGKAQNPSQGLLYERALHTLFALSAIKSYTNWKISSEVESAGKFDDLVFKSDEKCMLLQAKVQSGVKYTKDFMTTNPKKSDFSIAKYFLSYLTLRKSFKITPNSLILCTAAKLNVADIMDKLPADENLQKIFGSERKMYKAQNKEGMVDKFLDTIKQFQEKINENEKDKEELKNSDINTEDIKTFICSFVVVKIDLMSIKSLIGTKLNELGYKFPISSYEYVKDRVEEWYHLSTNKFVPMTKDYLMFILCGEHNRNFFQDLVNTNIYFKESHQFNSDNIICVQIHDNIAIAMHLIKILRSIQKSEKSYFPLKENILCLMQEKENIFHKMKYTMQYTVLCDMINTFKCDNMKYLVVSFLSLNKFQTLELYKKICDLTKENRNKKVFIIIKEDYLQSSKPLVKIIDDKIYFNSLESDTQNFILDKKNLFQGELVPLKDLKNIKNIIREIDEIEINECIEKIIFNKDYYSIGCNFQNQSKPDEFYINRSLMDNSKIFPEKDFFEKIDKNIVVITGPSGAGKTTILKKIVKLKKGKDEVDSKLTWIINVDLRKTKQFFRKEIEKNMTNLLCHNENITANVTPDSSYLAHLERKLIESMDKILIIDGLDENNYSDDIEKIRNLLADHNSLQALNISLVIMCARDYDCILKQLRDLHSCELRLIPFSPSEKSFYLNEHLKEIMSGNIKNDLFEEVTNSAPAFEAICSTPLSLEMVAKIIKNKVSKNNCIESLSKIFDTVTNICDFYSCYLQVIKDEFAQDNDKLRGAFDRYYIDSLRKFAAKCMFSDFPNLLDLLNVDDSYEINKDALNVGLIKELNGEYKFVHKTFEEYFAAEFLWDCLCNKKKQRHDLLLEVLNTVFLKSEYLGVLDFIEEILKINPNEKISKISSEYNLALTTVNWKKDISLLGNHGSIFIIKLVFDNYTNFTNLLNMEDKYGRGMTLVFFFHHPSVVKYFVEKAAKFNKANEIALNNLNEMLRWMPYIQKSYKENNMDLIKFLIRQCTLEDLNLLDNLGNTLSHYAVENNSLEIIKSLKEQGANLRITNRENATVVHIAAGLGALEVLRYLLEDCKMDVNVSDVDENLPAHLAASINSVSNIPISNKCKFSLNCRDIYGHTPCHTAAAKNALKSIKYLKEQGANLSIFDKKNRTVVHVAAQFGSLEVLRYLLEDCKMDANVSDDNGNLPAHMAAGNGNLEILRYLKSTGIDLNQCNNVGYTLVHMAAAGDAVDVLNFLENECELSLNIDVCDKYGNTPSHHAAAKNSFRAIKYLKEQGANLSITNKNNETIVHIAAGCGALKVLRYLLEDCKMDVNVSDVNGNLPAHFAASTDSVEILRYLKSIGIDLNQCNDRGQTLVHIAARDDSVDVLKFLKNECKFSLNCRDKYGHTPCFPAAAKNALKSIKYLKEQGANLSITNKNNETLVHIAAGCGALKVLRYLLEDCKMDANVSDDNGNLAAHMAAARNKVEILRYLKSIRIDLNQCNNNGHNIVYMAAGRDAVDVLSFVKNECKMSLNCSDEDGHTPSHQAACNNALKSIKFLKEQGANLSISSTLKETVVHTAAAYGAIDVLRYLLEDCKLDVSVSDVNGDLPAHMAAEGNKVDILRYLKSIGIELNQCNNKGQTLVHIAAKADAVDVLKFFKGECKFSLNLDLGDNYGNTPSHCAAAHNALKVIKYLKEQGANLNISNKKNYTPAHTAAENGALNVLRYLVEECKIDFTVSDVNGNLPAHMAAGGNKVEILRYLKSIGIELNQCNNKGQTLVHIAAAANAVDVLDFLKNECKSLNIDLCDKYGNTPSHCAARSNSLETIKYLKEQGANLSISNKKKYVLVHTAAENGALAVLQYLVEDCKSYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGY6</accession>
    <name>A0ABM5JGY6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497200.1">
        <property type="nucleotide sequence ID" value="XM_050641243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497201.1">
        <property type="nucleotide sequence ID" value="XM_050641244.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641243.1">
        <property type="protein sequence ID" value="XP_050497200.1"/>
        <property type="gene ID" value="LOC126878493"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641244.1">
        <property type="protein sequence ID" value="XP_050497201.1"/>
        <property type="gene ID" value="LOC126878493"/>
    </dbReference>
    <dbReference type="GeneID" id="126878493"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028380" description="EGF-like domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="382" mass="42395" checksum="CE902DA3752BD06F" modified="2025-10-08" version="1">MQRRFIHLVLILCSILHNTLGFNGLEPPVNSVQLPPCKACKTFIESFHKGLERTSKSKFEGGDTAWEEEKLGPYATSEVRFVEIHEKLCSEVHNGKDQCYKLLEEYEDTLEEWWFDKQSSERDLFNYLCVKSYQVCCPDLHYGKDCQPCPGFPDNVCSNNGKCKGSGTRKGNGQCQCEEGYAGSNCNTCNVTHYIVYQDEKKVLCAPCHISCAGGCTKEGPNGCNSCRSGWTQDSEKTCRDINECAAEKSPCTPLQFCVNMEGSYTCVDCDKSCGGCTGNGPDMCINCARGYYKKDNVCVDQAEEKRRTIVSFSRYFTYLGLCIATCIIFPRNSYIAAVVGVAVACYIAVSEYTLNSTNTIQTSGVEQQVSENVLKALTGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHM7</accession>
    <name>A0ABM5JHM7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497442.1">
        <property type="nucleotide sequence ID" value="XM_050641485.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641485.1">
        <property type="protein sequence ID" value="XP_050497442.1"/>
        <property type="gene ID" value="LOC126878649"/>
    </dbReference>
    <dbReference type="GeneID" id="126878649"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="455" mass="51793" checksum="DA417D6F1C2C0BE4" modified="2025-10-08" version="1">MLAPRHKNNINLIERELCALKNKFQNDQIMLTEVNNLSSRIENISRRKVEYKDTDFGPFLIMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMVLNSTEILEKGFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNVKIISARRLNRRVLDSSGTVTYIPTGTVQLLFDVRTPPKEIIIYSNLVTVDPYIPPVQQCFKCLRFGHSQRQCRGKARCPKCSDEHTVQSCTVSVPKCLYCDLDHLATNKICKEFERQKKINEVMVFQDLTFFEAAKLFPPIKEKPENSRMFQRRSRDFPSLLSSSPRAFTQALQKSPSSTPHFQSQSHVVPVKRKNKVILKDISYDKEAHKALLNEDLSRNLPRLPILNKLNDSQKYTGSQGPSFALSLTRNRVHSQDSVFSKNVDLTSDNNMEFAGFDESHNTSNFSKSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKD6</accession>
    <name>A0ABM5JKD6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498402.1">
        <property type="nucleotide sequence ID" value="XM_050642445.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642445.1">
        <property type="protein sequence ID" value="XP_050498402.1"/>
        <property type="gene ID" value="LOC126879432"/>
    </dbReference>
    <dbReference type="GeneID" id="126879432"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF37">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="256" mass="29278" checksum="8332E46B0E09721C" modified="2025-10-08" version="1">MELPDIGKQCAHPQCKQLDFLPLNCKCGKTFCSDHFTIHAQECEVSKILSEDELKKIENVYICSHPHCKERSIVALICKRCKQHFCVQHRHLAECKEKDEETLNKEKEKYAAPVRIFNEAKAVVDKQVEKNLADAKKKPKNREMANKVQLMKIKNKATGLKTIPTVDRVYFSVSYCEKSCPVFVSSQWSLGRAIDAIAEEMKLQNNNNKANEKKLRLFTKEDNVSLSTDMSVTIKKLLGDKILIDGDTLLIKYVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKV0</accession>
    <name>A0ABM5JKV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Negative elongation factor B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498566.1">
        <property type="nucleotide sequence ID" value="XM_050642609.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642609.1">
        <property type="protein sequence ID" value="XP_050498566.1"/>
        <property type="gene ID" value="LOC114330080"/>
    </dbReference>
    <dbReference type="GeneID" id="114330080"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67932" checksum="86EBBF767D1B453B" modified="2025-10-08" version="1">MSFHRGNSNPDFPLEALKVHGPNYLKHALTSCTDPLKAIEEFQLTNGILLPSLRPMLPLLDLHGVRRLDFHMSVVEELREKLINHINEIGKQEGKERDHKLKELLVKSFPVIRVKAMRPIVMAILKNIPQIEDHYLKVLVRDRELYLDTDTEVKRQIWKDNQSLFGDEVSPLLSQYISEKENVLFDHSNLATQFFGPSPKVRRQGEVVQKLAHMIGNSVKLYDMVLQFLRTLFLRTRIVHYCTLRAELLMALHDLEVQDIISIDPCHKFTWCLDACIREKNVDIKRSRELQGFLDNVKRGQEQVLGDLSMTLCDPYAINFLATSAIKILQHLIHMEGMARDNTILILLLRMLALGLSAWVMIDSQDFKEPKLDAQVVTKFLPALMSLMVDDQVRQLSGKLPHDEREAAITVIEHSGPLPDAVEAYLQDSTVASILAMYYTLHAARLKDRVGLLRILTVLANCKDDRAFEDPFLHSFVCLLIHNSDEFQAEDFCTALFDEFFFAGLSRDNVTRHLLKLLWYVHQKLPTSRLHSLMKALQPTHQHSEKVHLLYKLLQDKIVSQEETVIPPEMDIDINSPLMSVPTPAPYHHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMC8</accession>
    <name>A0ABM5JMC8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499094.1">
        <property type="nucleotide sequence ID" value="XM_050643137.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643137.1">
        <property type="protein sequence ID" value="XP_050499094.1"/>
        <property type="gene ID" value="LOC114326742"/>
    </dbReference>
    <dbReference type="GeneID" id="114326742"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="169"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="263"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="471" mass="52377" checksum="97E658B000CF714B" modified="2025-10-08" version="1">MKSKMFLYVVRVMMKNLQVVLITYWLTVGVAVGRGYHHRGDGRHVRNIDSNGISVLGGDFNHDLAFPRFSEPIPNVTVTVGRDALLACVVDNLRGFKVAWVRVDTQTILSIHHNVITQNPRISLSYNDHKSWYLHIKNVQEVDRGWYMCQVNTDPMRSRQGYLQVVVPPSIIDKETSSDMVVLESTNVSLTCKATGYPEPYVMWRREDGEDIRYNGENVNVVDGEILFITKVSRLHMAVYLCIASNGVPPSISKRVQLKVQFPPMLSIPNQLEGAYVGQDVTLECRTEAFPTSINYWTTERGDMIISGSDKYEAVSMDNGYKKYMMLKIRRVTKIDFGSYKCVAKNSLGETDGVIKLEEIPAPTTVKTTTHLATPVAKKGNSRGSTKGTLNDNRVNSVGKADDSSIADYDYDSEYTLPSNGPPPIQEPPGAFSGASRNFSSGGVVVFCFFLSILFFFFASAAAASSDEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQP4</accession>
    <name>A0ABM5JQP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500259.1">
        <property type="nucleotide sequence ID" value="XM_050644302.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644302.1">
        <property type="protein sequence ID" value="XP_050500259.1"/>
        <property type="gene ID" value="LOC126880443"/>
    </dbReference>
    <dbReference type="GeneID" id="126880443"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03868">
        <property type="entry name" value="M14_CPD_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045232041" description="Peptidase M14 domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1312"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="442"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1417" mass="160054" checksum="5FB0B6413EAF6E13" modified="2025-10-08" version="1">MILKAIIFLCVIFSLSETLSIRSAEYEKFLENPRYQNYDELTNLFKKLESEHPDLVKLRSVGKSVRNRDLWALEINSNVQNRTLLTPMFKYVANMHGDEAIGRQLMIYLALYLIHNYGTNDRVTRLVNSTDIYLMPSMNPDGYENSEEGRCESKKQYVGRENENSVDLNRDFPDQFDATKAGTILSGRQPETIAMMTWIISRPFVLSGNLHGGAVVASYPYDDSNSGRRCCVESRSPDNNIFKTLALNYAQSNPVMKKGNACKDDTFDQGITNGAFWYEVRGGMQDFNYVHSNCFEVTFELSCCKFPLAKTLPQEWANNKEALLTFMESTHWGAKGLVRNENGDAVLDADVVVVGITHNVTTSNRGEYWRLLLPGRYQMYAVAFGYQPSETVNVTVEEGKTVIQHFELKLHTPQSDNYMSPDTVNSTSDKYGFMIPDDKIFKHHHYDEMIKFMESYNNTYSSFTRMHSIGKTVQGRDLMVFVIGNTPDHHVAGKPEFKYIANIHGNEVVGRELLLYLIKYICERYGADERITKLVNTTRIHILPSMNPDGYEIAKEGDGSSLVGRNNANDFDLNRNFPDQYGENQYNRDPQPETKAVMNWVLSEPFVLSANLHNGALVANYPFDDTPNNTALENVSPDDKLFKHLASTYANAHKTMHNGVACPMFPNETFTGGITNGAKWYSITGGMQDWNYLVAGCMEVTLEIGCYKYPHAKDMPQYWLDNKEALLSYMEEVHKGVSGYVTSTIGNAIEHAEIIVEGIDHVVKSSKFGDYWRLLLPGKYNLTVAARGYESYTSEIVVPESGYVQYNATLMKDDPSHWASGYDFGILENQFQPKYHTSQEINEILAGMENRYPEVASFQGGDNLISISIHSLKISKEVENYNENKFHIAVVGNLFATQPIGRELNVYLARHLLEGNRFHDVLIEKILSNAVIHIIPVIDKAFEKIWGVYDRESLGVTKPDKFLCNDISADFRQVGEQLLNFKGRDSNNQDTKSVANAFKHFLLEEKVDLVLNIEGGSSGLLYPTTQDQVQIYKSLANQYTSSLKVPRNCISTNKGTDALLTEFLYHEYGIPMLTAKVSCCDYPFIANIPFVWRDSLEPLMRVLSSTLTGVKGVVENKGGEPMRNASIKLAGVSQFYEVSKNNATFKMILPKGNYTLEVSCHGYEPQNISVSVADQNITVLKVVLETLKQLAANQQATESANKEILDVHLDESLHQPFTGNVATGIRGYVSDYSNHPVVKAKITIPEKNLTVSVDESGKYGIPLPAGNYTVRFDALGFYPDVKLVGISAASNLPTVVMVKLKVNSTFYGIPRLAFVFILGFVGIVILMLGLACYKSCKRKNDYGPISQHSFYEDFKYDLRDESKEDEIFRTPLKKPILRPYYDEDEESEAEEEVQDKRYSLDDNYVDTDDEVVLLQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR97</accession>
    <name>A0ABM5JR97_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500460.1">
        <property type="nucleotide sequence ID" value="XM_050644503.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644503.1">
        <property type="protein sequence ID" value="XP_050500460.1"/>
        <property type="gene ID" value="LOC114336016"/>
    </dbReference>
    <dbReference type="GeneID" id="114336016"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF23">
        <property type="entry name" value="BCDNA.GH07066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="288"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="853" mass="97272" checksum="1BC77F965E853C20" modified="2025-10-08" version="1">MLISIVGINLALATSLAFLKYGFFDVLYGSFQLFLVLQFTYFIILLQGVNKMVDIVTNRVFDTYNKFSPSNNNHNQSVATSTIMRTFSRDQKFKRTLTREADQQAAENQLFDSKDNVPDVQAGKRRPFMGLSCQNCTLTSRESLVNKTTEILALRNILDYQLPISSGFIRKTFSHLYQVSQIKTYKYPQVADLVLEDARLKEAIDKATIQQFHDASNSDEEFYQKLLKNNQQRAKKLLVDMRSTLSDFLLKFTSWVCYKLLPCFLTSVVVHPGQVEMLKKAGKSSLPLIFLPLHRSHLDYILISFILLNNNIRSPLVAAGDNLRIPFFGSLLRGLGAFFIKRRVDPVMGRKDHIYKAVLHTYMNTCLRAGHNIEFFLEGGRTRTGKPCMPKYGILSVIVETFMDGTIEDALLVPVSVNYEKLVDGNFIREQLGQPKEMETFGNAVRGIWKVLNSNYGMMRIDFNQPFSLRELIKTFNTTGKMPIPNGIPHKLQSNPSTTSLYGTDVVSDEHKCIVERISKHIIYDCAQSSSVMSTNALAYLLLTCFRDGVSIEKLVVAFDALRRDLEYERKDIGFSGDSIDVINYAVEMLGPGLIRKEKVNNEDIIKPIAILPNVIELSYYSNTLVTHFALESVIAIAIDAMDHSSGNVVQQDLVENVQELCDMLQFEFLFCKPCQNLEQIITSCIDDLIDRKQIFLVDSEEENDLNIRSRRLARQFDDDDNEEERISPKIYKLNPNKEAVDALKYLRVPIAPFVDTYAITAFTLDKLVGRQLLESELLSDVLEELKSQLSSGGIKYGESVSVDTIKNALKLYQHWGILECHSEKKMRLYYLQESQDDSECISALYQRVQKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRX6</accession>
    <name>A0ABM5JRX6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500693.1">
        <property type="nucleotide sequence ID" value="XM_050644736.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644736.1">
        <property type="protein sequence ID" value="XP_050500693.1"/>
        <property type="gene ID" value="LOC114324464"/>
    </dbReference>
    <dbReference type="GeneID" id="114324464"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF60">
        <property type="entry name" value="3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57145" checksum="52974972D1E4C60D" modified="2025-10-08" version="1">MDVTEFREFGKAAVDYIADYIETIRERPVLPSVQPGYLGELLPKEAPQTGESWQDVLQDVDRIIMPGLTHWHSPRFHAFYPTANSFPAVVGEMLSAGFGCVGLSWIASPAYTELEVVMMNWLGKLIDLPEEFLNCSEGPGGGIIQGSASEVTFIGLLAAKEKKVKDLMEKNPNLKEADIKGKLIAYTSDQSNSSVEKSGLLGSMPMRLIPSNEKGQLTATALLETIQKDKEQGLIPCYVVACLGTTPTCAFDDLTELGPICNKENIWLHVDAAYAGTAFACPEYRYLMKGVQFADSFNFNAHKWMLVNFDCSAMWVKNAKYLVEAFNVQRIYLKDNHKGLAPEYRHWQISLGRRFRALKLWFVLKIYGVEGIQKHVRGQIALAKHFEDLVKTDSRFEVCTSSMGLVTFRLKGANSLSEQLLEKLDQRKNIFVIAGHFHEKFVIRFAICSRLTNAIDVEFSWEEIKSQADEILPSDKTRIAMEMSDKRSISSIEFSDTAIENSRMEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS12</accession>
    <name>A0ABM5JS12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500727.1">
        <property type="nucleotide sequence ID" value="XM_050644770.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644770.1">
        <property type="protein sequence ID" value="XP_050500727.1"/>
        <property type="gene ID" value="LOC126880722"/>
    </dbReference>
    <dbReference type="GeneID" id="126880722"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35345" checksum="E5F89B9A853805E6" modified="2025-10-08" version="1">MASSCKKVKTYHFHSEWEEQYFFTEVKDKNVCLLCNTSVSVAKKGNIESHHKTVHSNFEKSFPLHSAARKEKLKQLKKQLIGQQSIFLRTVDKNEAATEALYRVSQIIAQKKKPYENGEMIKQAFLEAADSLFANFRNKDEIVSAIKSMQLSANTVMRRVEVMSNDIFLQLRTDLDNCVYFSLQLDESTDVVDTAQMAVFVRMVFSDFTIKEDLLKFIPLKGHTTGQELFSHLKNIISSEKIPISKMVGLTTDGAPAMVGFDKGLVALCRKDETFSQFLCYHCIIHQQALCGNFLKLNNVMKRGKNCEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSJ4</accession>
    <name>A0ABM5JSJ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500909.1">
        <property type="nucleotide sequence ID" value="XM_050644952.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644952.1">
        <property type="protein sequence ID" value="XP_050500909.1"/>
        <property type="gene ID" value="LOC126880880"/>
    </dbReference>
    <dbReference type="GeneID" id="126880880"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="226" mass="26578" checksum="6A65C5498389F35C" modified="2025-10-08" version="1">MKEDEEKRRQEEKEEKEQRREVKEKRRQEVEEMRRQEEKEKEKRLRGISQITSRIDKLEEQHKDIKTYLKNKIDEQQNYLENKLILQQNDLTNKIDEQQNYLDHKLVQQQNDFESKIKQQQSDLKFNLERQIVDLERKIKNQSSLSNIVSATNIESEHIASSNSVVEPGAIRTTKILKPPTFDGMGNVSARANGWTEKEMAASLVVSLRGQAATVLQFLPQDAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSN2</accession>
    <name>A0ABM5JSN2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500953.1">
        <property type="nucleotide sequence ID" value="XM_050644996.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644996.1">
        <property type="protein sequence ID" value="XP_050500953.1"/>
        <property type="gene ID" value="LOC126880920"/>
    </dbReference>
    <dbReference type="GeneID" id="126880920"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="319" mass="36127" checksum="30F005AE597300CE" modified="2025-10-08" version="1">MLKARKVPFALKDKIEAELDRLIAQGVLEPITHPKWCTPIVTVCKENGEVRICGDYKSTLNLALNPEPYPVPAVQNILSTLAGGKVFAKLDMAQAYLQLSVNREAAETQTIITHKGAFKYNRLQFGISVAPQIFQKLIDTRLTGISGVLPYYDDILIVGRSEIDLDSKVRAVLSRFQEDISRLHLRKEKCVFRTKTIEFLGFQISEYGLRPTKDKIAAITNAPAPTNKTELQAFLGLLNFYHAFLKDKATIANPLHALLRKNVPWQWRFKEQKAFDLLKDILAKEPVLGHCSERKDLFLTCDASDDEGREYPVAYHSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT19</accession>
    <name>A0ABM5JT19_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501087.1">
        <property type="nucleotide sequence ID" value="XM_050645130.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645130.1">
        <property type="protein sequence ID" value="XP_050501087.1"/>
        <property type="gene ID" value="LOC126881087"/>
    </dbReference>
    <dbReference type="GeneID" id="126881087"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="205" mass="23615" checksum="3CDB6FE8AA795636" modified="2025-10-08" version="1">MEEDVPDEAGRGTIKRARTAKSECEVDPKEQVAALQEVIKTLRASFQKAEDKMAKKDEENERLRAEISQQSEKIKKMSSRCAVYGCAVDNMCKSFVPGTAFYSFPKDKEMQAVWKHLCKRKDSFNVKFARVCSKHFIESDYERNLKHELLGYTPAKHRPLKKDAAPSINLPTATNKQKQKANSADRTNRQHKRQQKRLVDDLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUU0</accession>
    <name>A0ABM5JUU0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501699.1">
        <property type="nucleotide sequence ID" value="XM_050645742.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645742.1">
        <property type="protein sequence ID" value="XP_050501699.1"/>
        <property type="gene ID" value="LOC126881464"/>
    </dbReference>
    <dbReference type="GeneID" id="126881464"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="196" mass="22908" checksum="647DC6254FCB29A0" modified="2025-10-08" version="1">MILYNKIANLGKNIIISWIKGHAGIRGNEIVDKLAKSALEIGEELPMNLLPISDIDIISRRHQKENWQRYYRNTRTGSNYKQMQPEIPIKRWFHSVSNSHFIRVINRLRCNHALTPLHMYSLGLTESPNCECGKEGDLLHILLECSHQSVNINKFYDNLNILKIPLPVYLNNLIFSEDINILKTIYEHIKNCKYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVP6</accession>
    <name>A0ABM5JVP6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502018.1">
        <property type="nucleotide sequence ID" value="XM_050646061.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646061.1">
        <property type="protein sequence ID" value="XP_050502018.1"/>
        <property type="gene ID" value="LOC126881669"/>
    </dbReference>
    <dbReference type="GeneID" id="126881669"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="7">
        <location>
            <begin position="38"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="6">
        <location>
            <begin position="282"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="8">
        <location>
            <begin position="445"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="616" mass="70964" checksum="4E4D42D29A7E05E9" modified="2025-10-08" version="1">MAEEVLNGDDKKKRMSVGLYTSCPPSIKQGVDSAFEQGYHFVVTQLTHPSYTRNLNNNSPSVIGRTDRVMRSSDWGRLVVGQLTPTIDLDSEVEHIREHSKMIFEEELGFASHLGVPAIWLTLTKPDNVQLARVLHSKLVSGFNYSVWVNIPMTHPSRYSPVAETEYDTWDWWNKFHTYCNYDKRLGLVLDLSDTKHLLPENELKRWIGEPIRAIVIPTSHFLTNQHGKPVLSKVHQEIIKKFMSLDVQYVIKNDTDSDLSLYNRYISFLGKKLYVYDTVTDFVDGFEDFLQNPLQPLTEHLETTIYEIFEKDNIKYTSYENAVYKAIEIFPKDETPVVMVVGAGRGPLVQAVINVSLALDRKIKVYAVEKNPFAVNTLVHRNKDEWDNDVTIVNSDMRTYKPPELADILVSELLGSFGDNELSPECLDGAQRFLKKSGISIPQSYTSYIAPLQSTKIYNEIRTNRQVDKTLQFCYETPYVTHLANFYEIASPQALFTFKHPNWSEHINNQRYKKLKFQAELSCLLTGFVGYFDTVLYKDVMLSIHPETHTPSMVSWFPIVFPLENPVYVEEGQSIEVAFWRAESSDKVWYEWCLISPVNSGIINPNGRSFFMRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWB8</accession>
    <name>A0ABM5JWB8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502234.1">
        <property type="nucleotide sequence ID" value="XM_050646277.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510776.1">
        <property type="nucleotide sequence ID" value="XM_050654819.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646277.1">
        <property type="protein sequence ID" value="XP_050502234.1"/>
        <property type="gene ID" value="LOC126881776"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654819.1">
        <property type="protein sequence ID" value="XP_050510776.1"/>
        <property type="gene ID" value="LOC126887360"/>
    </dbReference>
    <dbReference type="GeneID" id="126881776"/>
    <dbReference type="GeneID" id="126887360"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="209"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="413" mass="47710" checksum="9CDF503DFACA40A4" modified="2025-10-08" version="1">MKYTRCTMSPRYSQLKLPYEFDIQTSLKKLTIVCMVECCVVKYRYRFILKMDINFVDLIEHIDIVDEEQYVPLFALIPRKVFVRKNPFDKYGDAEFFVRFRLTKECVLHILEIVEPELEYMHNLNNSLSPINQLLVTLRMYATGSHLVTIGDFIEADKSTMSRIVKKVTGCLASLRPNYIKMPQTEPTINQRQQEFYEIARFPRVIGAIDGCHVKINHPGGEDGEIYRNRKSYFSINVQAVVSANFLFQDIVARWPGSAHDSTIFNNSRVKQRFEEGEFGNGILLGDSGYMVHNYLLTPFLNPSTEGERQYNISLVQSRVKVENTFGIWKRRFPILAYGCRLQLETTLNIIVATAVLHNIAQLNGEPEPPLDNVNAEEFEDLVQNGNIPAAPAPNNVIRDFRRELVDNYFTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXG0</accession>
    <name>A0ABM5JXG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502626.1">
        <property type="nucleotide sequence ID" value="XM_050646669.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517884.1">
        <property type="nucleotide sequence ID" value="XM_050661927.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646669.1">
        <property type="protein sequence ID" value="XP_050502626.1"/>
        <property type="gene ID" value="LOC126881929"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661927.1">
        <property type="protein sequence ID" value="XP_050517884.1"/>
        <property type="gene ID" value="LOC126892398"/>
    </dbReference>
    <dbReference type="GeneID" id="126881929"/>
    <dbReference type="GeneID" id="126892398"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="603" mass="68504" checksum="A0667040FED47A9E" modified="2025-10-08" version="1">MPRNYKRVTEKASWREEELQGALRAIQNGMSLRKAAIKFSIPKSTLHERLKNGTAPSGPSLGRKPVFSVEAENALAVQIKKLAKVFYGITPQKVRRCAFGFAQSNNIRVPFNKERKMAGKDWERGFISRHNITLRKPEATSINRITAFSRNEVTIFFNNLSRLMEKYAFSPNKIYNCDETGVTTVQRPPKIYAEKGQKRVGFVTSWERGKTTTAMCAVNATGTYIPPMFIFARQRMASHLQRNGPPGALYTCSKNGWITEDIFLTWLQHFQAFVKASKEDPVLLIMDNHSTHCTLQAYNFCRDNGIAVLTIPPHSSHRLQPLDVSFYFPLKTAFNSECSKYLTSHPGEKITPSEIAELFNLAFSRVATPEKAIKGFKETGIFPYNPDVFTDEDFAPAETLQSTVSDALQEPTQAEKLLKTNETTPEKNSSVNETELKNVSFAEIIPLPSCSHENVVKRQNKANKQHSIVFTSTPLKEELEKKEEKKNKKTTIKSDKAKRNVFVTQEGSTLRQKSKRTKIALNYKICEEGESEIEDDDDVRDKNITEDICILCGEFGKNSELWLRCVYCGHWAHNRHVLTLQKTKNLFATFVCKRCPSLPQHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1T1</accession>
    <name>A0ABM5K1T1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sortilin-related receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Low-density lipoprotein receptor relative with 11 ligand-binding repeats</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Sorting protein-related receptor containing LDLR class A repeats</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
            <location evidence="7">Multivesicular body membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Recycling endosome membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS10-related sortilin family. SORL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504146.1">
        <property type="nucleotide sequence ID" value="XM_050648189.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648189.1">
        <property type="protein sequence ID" value="XP_050504146.1"/>
        <property type="gene ID" value="LOC126883019"/>
    </dbReference>
    <dbReference type="GeneID" id="126883019"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057841">
        <property type="entry name" value="FN3_SORL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25814">
        <property type="entry name" value="fn3_SORL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="19 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="28" id="KW-0732">Signal</keyword>
    <keyword evidence="27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046057654" description="Sortilin-related receptor" evidence="28">
        <location>
            <begin position="17"/>
            <end position="2473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="2402"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="26">
        <location>
            <begin position="870"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="26">
        <location>
            <begin position="916"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="1922"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="2107"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1062"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1069"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1081"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1101"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1108"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1120"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1164"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1205"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1229"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1236"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1248"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1291"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1303"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1349"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1386"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1393"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1405"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1446"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1489"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1496"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1508"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1549"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1592"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1599"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1611"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1652"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1695"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1702"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1714"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1755"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="1801"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004545"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007041"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013467"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00029896"/>
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    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032450"/>
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    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504146.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2473" mass="276058" checksum="3473326B8E37B7FA" modified="2025-10-08" version="1">MYLLLFIPLFTKLTIGLDIQSKTLYGNIDDIGKSSKTNILDAPSDSAPYNGEIRRKRREVESSSSGVVTKANYLYVSQKQLMVHWVGENSKVIICLARDPASIVPDVPSAVFISYDDGDTYQNKTESFNLPDGGYATLERFYSHAKLGAHFVFTDIKHNAIYVTTDYGKTFERRDLNFTPSEISFHGLNPSIFVLLDKNTTKHKLWITEDSGKSFRMVEESVKAFYWLKEANDQYRLVVQRSEPNDLSTILLSMNLFKNRESQIYISNVTDFFIKGDYLFSTKYNEKGELQLYVSYKLGAQLLCIFDSKEKFKSYFIVDVTNTKALVAAGHSNTTSHLYVSESLAGNGKEVKFTLSLEDLFVFFPSTTWQDTWLHHKSEQAFADVYKVEGLTGIYIASRVTSKPVGAHLGPQHLGSVITFDHGTTWRLIQPPALNAEGQWSGCVTRRNCSLHLSQKFNQLLPDTRSVGILSSKSAPGFIMATGVLGENLKNQYGIYISSDGGVTWRQTLRELYFFNMGDHGGILSAAKYYKTNEETRHIEYSTDEGRSWYQTEFNNEKLRLYGLMTEPGKNTTLFTIFGSLPEYHQWIIVKVDFAKVFERKCTKDDYNMWSPSHSEDIRNYIPCEMGLQVAYQRRMPLAKCLNGLDYIQLKSTVVCECDLLDFECDSGFARVGSPPRCIRDKSSSLDVYRVPAPCKPGNFYNRTKGYRKIAADSCVGGFESHYLPDIVPCPFHEEDDFLLFAQRENIFKYNLIRNNLEQLAVPNLKNAVAIDFDIADNCVYWSDLTDKNIGRRCFVNGNATEILVSDDIISVEGIAFDWISKTLYFVDSVRAKIGLIRTNTNHNGRMRRTILNSTVLTKPRGIVVHPSQGYMFWTDWFPHAPSVNRANLDGSSNMTLFGRDKVQTPNGIAIDYFANRLYWIDAGLDYIGSSDLHGDGFVKVVSNTDVVSHPFAIAVFKDNLYWDDWRLHSIFSSDKENFNGAQVILKERKSLMGLKVVQHGIQIGTNACANTTCPYICVGLPKNRAACLCPDGLTMNNGKCVCPGNLEPLANFTCPSVAPTCAPSLFMCGDGRCLPNGFRCDGDFDCIDGSDEGNCPLPNCPEGSFQCENGRCIHSSWRCDGEHDCGDRSDEKNCTDGKPIICKFYEFHCNSGAVSCIPAVWRCDGEADCTDRSDESSCSNNTCNDSQFSCGIPSNRCISKNWVCDGEKDCIDGRDEANCTLNGRNETCLDWMFQCKDQHCIPFWWKCDGNNDCEDNSDEEGCSSPPNSPIDNTTSQRPLERCNGSNEYRCATGDCILASWVCDGQADCPDETDELSCDDKLPDGSGTPNCTFGMFPCNETCYPLSLVCDGKIDCKDGYDEKNCSTIGAAHPPIDNPTSHRPNATCESNEYQCNTGNCILTAWLCDGDADCIGGEDEKKCETSVNCSRSEFKCQIYGSCIPATAVCDGLVDCRDKTDELSCDDKLPDGSGTPSYPPIDNLTSQRPNVTCESNQYQCDRGNCILASWVCDGDVDCTGGEDEKDCDTSVNCSKSEFKCQTDGRCIPATAVCDGLVDCPDKTDELSCDDKLPDGSGTPSYPPIDNLTSQRPNVTCESNQYQCDRGNCILASWVCDGDVDCTGGEDEKDCDTSVNCSRSEFKCQTDGRCIPATAVCDGLVDCPDKTDELCCDDKLPDGSGTPSYPPIDNPTSQRPNATCESNEYQCNAGNCILAAWLCDGDADCIGGEDEKNCDPSVNCSRSQFKCQTDGSCIPATAVCDGHVDCSDKTDELSCDDKFPDGFGAPNCTFGMFPCNETCYPVYLLCDGKIDCEDGYDEKNCSTKARVYQINKMEVDERFTNASTIYINWWIVRPTGLELEYQPSIKKIGDEHWRNESWIGQPYYQFTNLQPFTKYNMTVYVRIKNTHVVFPPAIYNVSSTSESIPSEPWNVSARQRNGSHILISWNKPRSPNGLIVSYELCWIYPNSAEIRLKLSGNETSHMLSQDFDNGLNYTFWVIARNRKFESKKSLPATLMFDGTSNIEGVKNIKVKEEDDTISLTWDYSKEVEGFDVRVFTDRPYPNLPPRTTSTKNITLKLAPGVNYKVGINAFKKDLVGPTSYISFRRAGNSLPEIESLQVIVLKDIGTAVKLRWDRPKYAKKLNWMYGVYYGINHQQLFESARNTTINESITITNLDSCENYVFSVGLVGPIGFGPLSGNIQQVSTSENPRAPPKRLIVEEDGNDPLQMKISWIPPCPSRQPVFYKLLITEKSTTQTYFRKADGSHANSYVFKVLHGGIYEVKVATDEPNAIYSKAVKYFAPAISPPVELRVGAINNGSYVVDWKDEDLPQNIGKYRYEVFVHDGNKLNESSAQKFIVDGPPFVYTNASAKMYTFAVRIKTSKGLNSQMSHSLSLENLNVQAPQNMTAVIVPSVLVIIALLAVVAFLVVRNKKIQNSFTRFTNSHYDTRSEAATFDDNNLEEDDSPHIRGFADDEPLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3X4</accession>
    <name>A0ABM5K3X4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050504894.1">
        <property type="nucleotide sequence ID" value="XM_050648937.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648937.1">
        <property type="protein sequence ID" value="XP_050504894.1"/>
        <property type="gene ID" value="LOC114325063"/>
    </dbReference>
    <dbReference type="GeneID" id="114325063"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="876"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="815"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1000" mass="112576" checksum="B543CA67811360E8" modified="2025-10-08" version="1">MDVDLLRDGEQFSTFDSSSFLDPYPDEGTTLDSIHSLTPNGYEWTLEGEQEINGDIALIPVCDMNLTNINDTAPSIDDFHKIMSDWQQFINVDASTDFAIEEPILNTKDVPQPCTETEDLLNTSNFDITEYLNDVDPIPQAPVSTNSANVSPTSSSESCTSNTNASSRKFKAGMKKMDLQAQRYIIEEDDDDVDVETISECEENTPVLEAKDLTTLLEQFEATQIPHFPDNFVSESIPSHIFEEEEEEATPVNIKQVVKKEEALVVKQEAIDDDYTYGYGRRKGSDKKNRKIDKRKKDDSASNLKEQAPAVSKKEPQLPLIVKKEPVSPIAIKKEPQSPLVIKKELVSPVVVVAKKEPVPPVIVKKELPSPIPNKSTPKPVNTKNVTTSTSKPQSVDPPSLKPDEYIQKLPKAPEKPLQPSKKPLETPQKVSDSRQKPSVCSESTTSNTPNKQILDYLPQELIERIKESGKRKPISVIPPIPTKKRGCPRMQEACAQLSRNKMIKLVGDVHLDHNYCSMNMVESYPKNPKKDSGFESAEEEERTVIGNQPTVKTADGKLMVSLLKVNTIHANKTAQKKKLNFEEYKRRREGFGKSQNNSQSCSPVTSTCSSPLPEDENTRLLKHQEKLKKMAKEVLNTPPKGEKKPEHALVVAPPTPLVVPPDMVMKTLVSIGVNTDFKVRRKNLDPLAPVERLDEIKPLLQKASDMINGNSLITSVIENIPKVIDSCDPKHIAPENKDRLEHGEDKTIVYLPKNRVCQETQSVECQTNISLIQQTKASRYRRRRVSSSSSESSDSSQGSRRSRSPARRQKRNRSSGTSRCSSSSKSSRSSNSNSSTCSTYSSSRSSSRSRSRSRSSSPRYSRREKERLKEIEERRVIYVGRVAKGSTKEDLKMRFQRFGPITNISLHSRDHSYFDNYGFVTFANKLDAYEAIEHGNDDPWQPKYDLSFGGRRIFCQTTYSDLDNMRDESGYFIQRGGPTDDSFDQLLRDVQDRIRKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5J0</accession>
    <name>A0ABM5K5J0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505455.1">
        <property type="nucleotide sequence ID" value="XM_050649498.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649498.1">
        <property type="protein sequence ID" value="XP_050505455.1"/>
        <property type="gene ID" value="LOC126883827"/>
    </dbReference>
    <dbReference type="GeneID" id="126883827"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23796" checksum="FDB7A3EF731C2D9A" modified="2025-10-08" version="1">MLNLSLQGRNQTVSHLIGTINGFRNKLNVFKRAVEKYNLTHFPSSLQIAEEFNGEENIEFSSCISQIEQVIDEFNTRFEEIESLKSSVLLYNNPLGATIDDQPPNLQLELCDLQADMFLITRQEKGPEFFKLLSKEKFPKLRDFGLKMTSMFGSTCESAFSSMKYIKNKNRSNLTNSSLRHLMRLSTTELEVDISSLVDEADRPQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9X3</accession>
    <name>A0ABM5K9X3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506989.1">
        <property type="nucleotide sequence ID" value="XM_050651032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506990.1">
        <property type="nucleotide sequence ID" value="XM_050651033.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651032.1">
        <property type="protein sequence ID" value="XP_050506989.1"/>
        <property type="gene ID" value="LOC126884796"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651033.1">
        <property type="protein sequence ID" value="XP_050506990.1"/>
        <property type="gene ID" value="LOC126884796"/>
    </dbReference>
    <dbReference type="GeneID" id="126884796"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="195" mass="22595" checksum="D32A0B69E4B96A8C" modified="2025-10-08" version="1">MTQRLFCTDDPQGVNQRRNQSNPGVRFEICPEQPIQYQSQQMGEVRNNNQRNGDLRTPCSSLYNDFIEEDGAQIVDIAPCPDPQFHRGPTVTLNVVPLNQQFRDKNNNDECRQLIREREERWRNRIVAADNIIPPDYVCPHLDTSPLDDAVLMSYMDNDHFEVLVDHSAVLLHDFALPADFYGDVEELFNCCDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDX1</accession>
    <name>A0ABM5KDX1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508390.1">
        <property type="nucleotide sequence ID" value="XM_050652433.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652433.1">
        <property type="protein sequence ID" value="XP_050508390.1"/>
        <property type="gene ID" value="LOC126885711"/>
    </dbReference>
    <dbReference type="GeneID" id="126885711"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="189"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="465" mass="54016" checksum="FE707047CEC33A63" modified="2025-10-08" version="1">MQENGLEAELKNTIYRFVKSKKRESNTHDAFFRKCQIHWDKRIHKSLNSMCNELGISLAKPRTTNDKEEILSKWTELSNYEVNIQKYRPVYAPKDFLEVLLNLKGPIDEKSSEGSTGWQFSQIPLKVKNLGDLRSFYSELSRGEQILTATNSLVMTHSFAQFEEERIHLGEKVLLKNYAPIAQEFLKKGCPRCLRARVWSLLLGSEVKEYEYAYFQSLKEHVLQYDLMIDKLIIKDITLTASNDDQYFVFEDVLYQVMLCFSRDSEILKNLPTQPAFMQVVIKGKTGTPESTNTTIVFPPSGVIPFHGFSMYAAPFCYIYDDPVHLYFSFRAFYLRYWHRLHRVCGNSQGVVALCLLFEKLLQCFDPLLWNHFRKYHVPPLRLVIKWIMRAFSGHLPPEQLLTLWDLVLAYDSLEIISLLAVVILIFRRDNLLKVTTLQNIEAVLADLSSIAVIPLLQMALMKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KED9</accession>
    <name>A0ABM5KED9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508555.1">
        <property type="nucleotide sequence ID" value="XM_050652598.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652598.1">
        <property type="protein sequence ID" value="XP_050508555.1"/>
        <property type="gene ID" value="LOC126885841"/>
    </dbReference>
    <dbReference type="GeneID" id="126885841"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="206"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="301" mass="33418" checksum="4752E9D82E38DFE5" modified="2025-10-08" version="1">MGVKETLKEAAIQVGSGGSAGFVEVCIMHPLDLVKTRLQIQSRTMDRNDPRYYKGIIDCFGKMYKHEGMFSFWKGIVPPILAETPKRAVKFFTFEQYKQFFMFGSATPTPLTFSLAGLGAGATEAVLVNPFEVVKVSLQSNKAKSSEVPSTWAVTRVIIQENGFGLRGLNKGLTATVARNSIFNMFYFGFYHSVKGMVPEYENPYTEFFKKIGLGFISGSVASCLNIPFDVAKSRIQGPQPVVGEIKYRTTLNSMAIVYREEGLAALYKGLLPKVLRLGPGGAIMLVVYEYSHKYLTEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KK23</accession>
    <name>A0ABM5KK23_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="RefSeq" id="XP_050510463.1">
        <property type="nucleotide sequence ID" value="XM_050654506.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654506.1">
        <property type="protein sequence ID" value="XP_050510463.1"/>
        <property type="gene ID" value="LOC126887145"/>
    </dbReference>
    <dbReference type="GeneID" id="126887145"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="442" mass="50156" checksum="907845E1A9D70B09" modified="2025-10-08" version="1">MQSDGSIVPDHHVYVIPSKLIKTTDDMRSWEKSETYYEYLGFIYTLNDAIKGKSIEQASANVSTEIDKICELLDIIGILMEECPTVEHWEEKCNPAFRDWYERVKNQAIILLQTVIPEPLHRAIPEIMIYFVEGFGGSINVEYGTIHELSFLLFLCSLFKIGYLKTSDISAVATKVFLRYLKLARKLQITYQMEPFGNEGVWSLDDYQFVPFILGSSQLIDTVLLSPSSFLKEAIVNRYSSKYMFFNCIEHINTRKSGPFAEHSNQLWNASGLSSWATVNSSLIRMYRETVLSKFNLVQHINFGSIFTLNQAEPGSSIRRPKTSLAALHKTLANVEFSGQRGIRSLISADVRSDIAGTAGKSSSNSSSFSRGQQDPKLSDDRHFKEDRDDLISESLQKTPKTSFDKDSMFKDETEKPNPEFSSRRSKNASVTIVLDNEDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMP9</accession>
    <name>A0ABM5KMP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511476.1">
        <property type="nucleotide sequence ID" value="XM_050655519.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655519.1">
        <property type="protein sequence ID" value="XP_050511476.1"/>
        <property type="gene ID" value="LOC114334874"/>
    </dbReference>
    <dbReference type="GeneID" id="114334874"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF6">
        <property type="entry name" value="RE22408P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="529" mass="60367" checksum="6192414DAED0932F" modified="2025-10-08" version="1">MNKINYTVLKNDKIGRYLVASRDIKGGEVIISEKPLLIGPPISGLLICFNCCKEIKRIAYVLCASCGTAILCNAKCTGKFHTKEECEIFASKQINGRCIADNCQIIFPLRCLLLKATNIDSWTDFMKLECHLEARRHTPIWGRHKTEVEEILREMNVISEEDINDEVIQKICGILDVNTFEVRPPNSNISIINPEKQCLRGLYIKAALMTHDCTANTLLSVDDDFTMTVKASVDIPKDALIYFNYANVLQGSLDRRQHLREGKYFECNCKRCLDPTELDTNISSIKCHRCPQGFVRAVMPSDPKSEWKCSRCGLKFVHFLVNIIVDEGKRLIQNLDQNNLEAFEDLHTRLLKTFHPNHHLLLEMQQNMIGLYSLYPPSVANLKKKIVNCQSLIRVLSVIEPGISRMKALALYQLQSAMIDLSHKNYKEKSINLKCLVLNLTTAEEILSESIRYLLHEPAKSPEGTVARTAMNELKMLRMSIKNIKNDIVANDMFNNETKFQENGNLDAKGTKYDELKQKQAKKNRRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP65</accession>
    <name>A0ABM5KP65_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511987.1">
        <property type="nucleotide sequence ID" value="XM_050656030.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656030.1">
        <property type="protein sequence ID" value="XP_050511987.1"/>
        <property type="gene ID" value="LOC126888025"/>
    </dbReference>
    <dbReference type="GeneID" id="126888025"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66673" checksum="4C9DDBFF2C24BAC0" modified="2025-10-08" version="1">MALKESSYLDQLRISSPEAAYRYLDKIKQLNCDPYALSEVDFDYGLTYVPPIASMDILTYIVFTHSFYTHEQMRAYKSLAAYKYFKSGFVEKVGFKVINDLVLLIGKVQHSMRARETKLRVWIIAETGGSICTAHCTCMAGLGEVCSHVTAVLYAAEHAAYLKQQKNEKNVACTDVKSTWPVPTQSGTHPIEAASLDWGKVIEEKNYKEIPPMDDSEMLDLLQELQNSNCDAVLMRHVEPFASQLPDENNEKVSIPVLFNVYHKKYEKMPLDDLIQLGMKCKMEVTQNIRREIEDKTQDQRKCAEWYRQRTGRVTASIFKDVCRTNVEKPSLSLIKSICYPRKISTRAIRWGINHEQLAIDAYKKETSRNHRDFIVNTIGLVVCMKWPQLGASPDGFVYCDCCAAGTLEVKCPFSLRENGNLQEYASRKDSCLECDKTGSVKMNKKHKYYYQVQAQIFICKLNYCDFVVWCPNFIFIERVLPDIKFWEEIKDKVLNFHAKVIMPELLGRYYTSRVPGGNITKWCFCNNVDDGQPMVQCSYENCNIFWFHIGCVNLLEKPKTRWTCSICNQKLFHDYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPB1</accession>
    <name>A0ABM5KPB1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512029.1">
        <property type="nucleotide sequence ID" value="XM_050656072.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656072.1">
        <property type="protein sequence ID" value="XP_050512029.1"/>
        <property type="gene ID" value="LOC114333903"/>
    </dbReference>
    <dbReference type="GeneID" id="114333903"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1086" mass="121834" checksum="B9D13CB0B4A94CB4" modified="2025-10-08" version="1">MEEILGKLLVSNSKTIHEGTKELKEAFKKPEAVLALCDVLVTSTHPQIRQTAAVLLRRKFGKKRYWSRINVDIRKRIKEGMLQALVNEQEKLVKNSIAQFIGVIGKHEFPENCWPEVLQFIHTLTSGENNFDKELGMYTLSIMTEIAQSSYIVHAESFAILFTNIINQLTDLKLNVGYYTIITMKNLVPAIAGNQQMINVYHSLLPKILQIINTVAMDDEKKAVDMFELIEELIEYAVSVVAPHLKLIIEMCLQLASNNATPKIVQIKVVGIVGWLIRSKGKVVQKNKLVEPIIDVLISLMAQQPEDEGNEEYFLGDPDQFTSITAATQTLDLIALHIPAEKVIPYILTKVEPAIQGGDIYFQKAAYLALAVLAEGCSECIRHKYLQDFLKCVCTAIHNPNAVVRNAAFFALGQFAEHLQPEISQYSSELLPVLFECLRQIFVQMAAERKDPPSLDRLFYALETFCENLDEGLVPYLPTLMTRIFEALDPEGFSLQLKRVALSTLGSIASAVKEGLLPYFDRVIEFLKIYINSDPNSEMHQIQCYAIESLAVVAQFIGPDNFRPLTGDCLQLGLKILNETSDPDINKSVYALFSALAINMKEELSPALPKIVNDMIESIQSSEGIVTHYDDEDKDEIDVYAELSEEDDDIEEDIDGSSTGSADSAQCRYSVENSYNEEKEQACLSLKDICVNTGVAFLPYIEKCFEEIFKLINYPQDDIRKASVEALLQFCISLHKFSTPDNKQSLYRALQMFVPKCAELIRIDEERSVVMVCLDAYATLLDEIKGEVFVIDGHREAIMNCVIDVLNLKTMCQDTDLAGQTENNDDDVEAEQDELLLESAGDVIPKFSAAVRPDDLMSYFPNILQLLSARTKKQHSLSQRSFAFGTLAECMKSLGIYVEKFVPTLLNLWFTGARDSADEVRNNAIFGLGEMILHGKDKIFSHYPEILQALSTSVSKEAHSGTLDNICGALAKMIIVNPNAIPLDQVFPAFVQKLPLRDDFQENEAVIKCIFSLYQQGNPVLKEHLLDVIKVLAHVYCENQTPNDDVKNLLNDFLKTINRDFPQEFANSVSSFESSSQNSLQALLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPG0</accession>
    <name>A0ABM5KPG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512077.1">
        <property type="nucleotide sequence ID" value="XM_050656120.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656120.1">
        <property type="protein sequence ID" value="XP_050512077.1"/>
        <property type="gene ID" value="LOC126888098"/>
    </dbReference>
    <dbReference type="GeneID" id="126888098"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7357" checksum="7DD5717FFE31B0E4" modified="2025-10-08" version="1">MYKNAHAAIRANPELEKKAEKAPAPAKRWNRRKLTLADLKDRVAQKNKSYLAKLQDQDTHSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSD0</accession>
    <name>A0ABM5KSD0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513091.1">
        <property type="nucleotide sequence ID" value="XM_050657134.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657134.1">
        <property type="protein sequence ID" value="XP_050513091.1"/>
        <property type="gene ID" value="LOC126888734"/>
    </dbReference>
    <dbReference type="GeneID" id="126888734"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="426" mass="48233" checksum="77420669767D7A30" modified="2025-10-08" version="1">MFYESTKNMKLLCGLAQFVKSFFIFLHSHEHERNNRTARLILTRPITLFSKDSCEIHYEEYLTPYANKYVQFQIVASKQVVVTLKDRNLNMYEAESNGNKYIVFTNKCTCINFTSMLLPCKHIFATRLVEKIKLFDKSLCNERWSKEFYIKHQRVAKGVTTTSENISLQPFSVTQAVSPSIQTVNQKRKKALFVTNSLANLASLSSGSSFSYKMKILEAIETAWRQGHEVALNVISSSTDENTDQSIIANNEDSNGFCGILSANGHDQVARPKDLDLNIKADVNEILVTDEMHNAEVELVDLNEEQNNKDSFSEKGHGHLPISKDILDTNIIADEILLIAEMPNVEVEFIDQMEDQNNTEILSENGHGQLPIPKDSGDSYITDPNESNKKIQIISKIVLPPKIKVKGRPKGADETVIGLKRKRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSW0</accession>
    <name>A0ABM5KSW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GBD/FH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513273.1">
        <property type="nucleotide sequence ID" value="XM_050657316.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657316.1">
        <property type="protein sequence ID" value="XP_050513273.1"/>
        <property type="gene ID" value="LOC126888883"/>
    </dbReference>
    <dbReference type="GeneID" id="126888883"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF9">
        <property type="entry name" value="MULTIPLE WING HAIRS, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="39"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="816" mass="92898" checksum="D85FD2137750D098" modified="2025-10-08" version="1">MTLRELKKKRQYIEPGGRTTPKSNEPVENKRYSRQEESTREKQRPPIYNPEDYAYWIKKWGKKSGHGIISLYSTSSMSDLESNYSQSHSYRDYRNPMLSSSGMEMTLRQFGTVSELLAKLKCDLRLAYPSFVQEFVADPLDGVTVLLDLLRAIQLSQSNAGQVQNCSPGGTTPKLSPALQRRTLLDELACLQCLYNCCVRYSESVRKLTASSAGLFTLAICIMSNVNKSRILALQLLSKACEPPSSCHSAVSEAMSTLRLRFGEPVRFRFLVGMLSSAGSHIELLTSGLKFINSFLNTAESVQKRVYLQAELEQAGFDLAMIKKNIGVNVNACETLFDEMDVFEKHFVDIENLTIRTESAEKENDNLRDRLADLEQKIQVLQEEKGILISMDQCLRDKCSELREEVQSLKSAQSVDASSRLSKNPESTPEDEGISSSERTPSPEAEIQPTSTVYEIYTAPEEPLGNESEEETTIEDVIQELQDIISNEETQDYNRENLKLNNERRRVEESQIAGKFKIHLDIDDYALQSDYEIIPSNLQPEPPRKSRSLIHLFMPTADYDYHSKELFFETESLTTDSSFSLVDVSKYCPPLFENKTESKPIEPTSIKNVSHNKNSKVTVKRSESFRQLPKTTPNVEQNIYSERYQFNIPPEVSTFKRNLQKNKKHNLSNKCMSLDRVDNSIDVSNGVVLNKVKTIASRSKSDSENILTTTNKSITNVYINQDKDIKYKLGSYSEEKHRMFLPSYSEENEVLYYFPRIQERKPSNSSSFLLNRGFSNAGLYSGQTFETHHYFNRSREVIGSDCRSSGKLTDFPSGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KTY4</accession>
    <name>A0ABM5KTY4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513654.1">
        <property type="nucleotide sequence ID" value="XM_050657697.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657697.1">
        <property type="protein sequence ID" value="XP_050513654.1"/>
        <property type="gene ID" value="LOC114333394"/>
    </dbReference>
    <dbReference type="GeneID" id="114333394"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="157" mass="18848" checksum="08B047BFBE740935" modified="2025-10-08" version="1">MAQAFVTTTKNSFRWNVQEKVKPIRHEHKFDECYGKNIEWLTEQDLNEKMEKFEKIKASVAQLKRDRMSRTTYRIDYCKHEKKAARTVGSEDSFENQLQERYYKKIYQKKKGKILPTVETQRIFGFLAPSRMYTQKSNYQHDYGQVGFDRLFNGNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVT7</accession>
    <name>A0ABM5KVT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514300.1">
        <property type="nucleotide sequence ID" value="XM_050658343.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658343.1">
        <property type="protein sequence ID" value="XP_050514300.1"/>
        <property type="gene ID" value="LOC126889765"/>
    </dbReference>
    <dbReference type="GeneID" id="126889765"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134665" checksum="859D88EF66F2A1B7" modified="2025-10-08" version="1">MDTQDTANECRLCLSQKELVSVFECDDSRSKKMKDLIFLTTGVEILEKDVISRKICANCSKVVVKMNEFRERSIRTDKYLKEKCIEHLKATKMKIPNTNITITTRKLPRKEKIDDSNDNDNHCQNELDESKKCENFQEKCIEHSRATKMKIPNSNVTITARKLPRKEKLDDSNNDDDNHCQNELDESKKCENFQEKCIEHSRAMKMKIPNSNVTITARKLPRKEKLDDSNNDNDNHCQNKLNESKKGESCQEKCIKHLTATKMKIPNTNVTITTKKLLRKEKLDDCNNNNDNLCQNESDESKKEENNRYSHNASIPRKVSVHKSVSELFLRHPNLKLRTDVLAFDVSPCVSLELDEVEKYCNDNNINLKLATERATRVNTARKKTTALNNKNISNWNSSSEANTSKDKIISPNNPENAQAPLKVSPISIRLGEDRNNFKVTPISIKLADDRAKFKIISDSSKRKRESSENTETITVTKQSKIKRRRLSSSDFTSDKDQTNPTLFETLGLKPSQPSSEQTNTYKCNICLSVQKNAKALKHHYREHFCCSFCKTRFRLVERRISHEKKCTVRHALNSKPYVKLTRVELINKYPLHSGNSVINKNSVDCNEVIVLSDDDEPVIKSTNVSNVSNSLVSKSNSGVLLGITHAENSRSKVSRPEKQIKTANAVSVVTTESSSIEKGTNDGEAELGKITTYSPAKSNTFPKPPATVGNNDVLPQTDVSSNNAEVPPVQYSSTAIVRPDVKIKEDTLLNANNLNGSDITLLKELLKHAKGVESKSLKEPTPEDISRNGTMKNMFLQLALYRVPVNIRHGQHSVTFSKAETEINKEVTMWDDINPLSLLNRNANMDITNVSLNPSETVLVNSGQTNNPATLQRSVPVPVILNSAVSRMHQTLGIMLTPNTQYSKTHSSSQAQTIISSPNTPSQSSVTVTSPNGVRTVFSQSFTPNFLNNSNAHLLNSTNNTSPQNSNASSQQILPRTLNNAIVNNATNSSQKEFIPISNTSINSTNGVSHVFRSPGDLRTVVIDGKSVVIDSNIIGYQRLRGAPTESNMQFIYSNSNNRQIAAPLLNNQRVILNATVANCTTTQNTVTSNNIQQNTLNTTSLIPNTNISNNFSNFSVPQTPVVPPAPLLNNQCVILNATVANGNTTPSTVTSNDIQQNTLNTISLIPNTNTSHNFNTFRVPQTPVVPNNLTYSKPMIRVKNICDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW31</accession>
    <name>A0ABM5KW31_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514394.1">
        <property type="nucleotide sequence ID" value="XM_050658437.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658437.1">
        <property type="protein sequence ID" value="XP_050514394.1"/>
        <property type="gene ID" value="LOC126889799"/>
    </dbReference>
    <dbReference type="GeneID" id="126889799"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010800">
        <property type="entry name" value="GRP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07172">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047277491" evidence="2">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="92" mass="10036" checksum="983A085406F65B40" modified="2025-10-08" version="1">MMGNKLICLMICFACISLYLMESVEAKNYDPNPPQRSPSPQERGRSRTVPAHLQNQGQNGNGHQNGNGQQNGNGHTNGNGQQNGNGHHNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXL3</accession>
    <name>A0ABM5KXL3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pro-resilin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514929.1">
        <property type="nucleotide sequence ID" value="XM_050658972.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658972.1">
        <property type="protein sequence ID" value="XP_050514929.1"/>
        <property type="gene ID" value="LOC126890125"/>
    </dbReference>
    <dbReference type="GeneID" id="126890125"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31110" checksum="42158822B8A2E9A8" modified="2025-10-08" version="1">MSINNKHEIENKVAVFCCDNSNTNFGGVKMRGTNVYSRLKEYIGINIKVGKSNGCSSHIVHNTIQHAVDGLPAEIETIVLKIASLLIINDLVWAEESESEEESEDIEEDSSSDQREDDEDGSPQKFNNPKEETENSKPESHNPEKQIDIFSYHPPGVSAAVPHFHPIHSPRRGDDSFSYHKLNGPLSKNVQQYLVPNSNQLQAGSQSIDYRGQPDYSFAYGVHDGLSKNSHTHMESRDGNDLHGEYRVLQPDGLVRIVRYVQDPKEGFKMTVTYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY22</accession>
    <name>A0ABM5KY22_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidoglycan-recognition protein LC-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515093.1">
        <property type="nucleotide sequence ID" value="XM_050659136.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659136.1">
        <property type="protein sequence ID" value="XP_050515093.1"/>
        <property type="gene ID" value="LOC114334144"/>
    </dbReference>
    <dbReference type="GeneID" id="114334144"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="7">
        <location>
            <begin position="245"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="6">
        <location>
            <begin position="257"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="7">
        <location>
            <begin position="421"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="6">
        <location>
            <begin position="433"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65586" checksum="4760A287100BA306" modified="2025-10-08" version="1">MPQAILPRPLENPCFEDDNKRQLKSYHENEVDTIDISAVNPDDDETEEEEEEIVDYDNAIVVNDQPHLPHFGSVSVVNSNDVHFGNKTVYKGPVTIKQFVYPKSDVTSEVFSNLSEVTGLNELNSITGGNKVLHSEGVDNASFVKEDLEIGRDKAEEREQETDSVTDRIRKSITYVKAFPCKKPKQTLLLVFLLILSLTTISAILIWRNPTRVIQIDQNKDNEEEDKNEPIDYTADTNAAPKEKLRIVTRINWLAKPPSGPINNLTLPVSLVVINHSATESCNSQASCVYQAHAIQAFHMESRNWSDVGYSFMIGGDGAVYEGRSWTKEGAHTLGVNDKSIGIAFIGTYTDHVPPALMLNAFHNLVNKGVNDGYITKDYKVMGARQFSGTESPGKAFYDVIKTWVHWSEKLSYVNGTTGDLRIIKRIFWVAQPPSGPRNNLTLPVHAVIIHHTDTESCDTKGACILQTRTIQTYDIESRSLNDIAYNFLIGGDGAVYEGRGWKVEGAHTLGANDKSFGVAFIGTFSKELPPKIMVTVFYKLVDIAIQKGYLTKNYKIMAARQFSGIESPGKAFYELIKSWPQWSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYN4</accession>
    <name>A0ABM5KYN4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515303.1">
        <property type="nucleotide sequence ID" value="XM_050659346.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659346.1">
        <property type="protein sequence ID" value="XP_050515303.1"/>
        <property type="gene ID" value="LOC126890429"/>
    </dbReference>
    <dbReference type="GeneID" id="126890429"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="285" mass="32323" checksum="43052E7D2DE72814" modified="2025-10-08" version="1">MATPSKKKTSPEQLNHMAEFVTQNKILVHGKTKPSEASNKTMEKLWDELTLTLNSMGCGPSKTKMQWKKTFIDWKSHTKKKARDAIRCQNRTGGGDEVAKKLTPAEEKLMAAISYISVTGTEVIELGLNDEVVAEDVNPPDIDMDVSFTVGDDDFLEPTAEGSSLSRVIKIQNVEPSSKKKTIKDKSSNLQKAAESFMTGQKETAEMINKLLDTAAKAEGDHQWREREQRLKEFELNIRLLEAQNEAKKLELMEREIRMKERELGIEDTEIQNGSYNNFTMHRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZT7</accession>
    <name>A0ABM5KZT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protamine-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515702.1">
        <property type="nucleotide sequence ID" value="XM_050659745.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659745.1">
        <property type="protein sequence ID" value="XP_050515702.1"/>
        <property type="gene ID" value="LOC114337862"/>
    </dbReference>
    <dbReference type="GeneID" id="114337862"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024460">
        <property type="entry name" value="Protamine-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06382">
        <property type="entry name" value="Protamine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24183" checksum="4B66B6736246723F" modified="2025-10-08" version="1">MASKKSGGCPNRLTPPEYCPARAKKERGRSKSRKRGSSRGGRSKSRKRGGSRRGRSSRSGRKSSRRSSRRSSRRSSRRISKGRRSSSRRSKTVRGCPCPKSQQRSKRKQSARKRSASRRGKGEGKEGGGGKCHKPGPITVNPFLNFLREFRKRHCGWHITKIAIEGAKQWCSMSKDEKRRYYTEACQMMSKGGGKRKKGGKGGKSKRRRSRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L113</accession>
    <name>A0ABM5L113_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA-binding protein 25-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516129.1">
        <property type="nucleotide sequence ID" value="XM_050660172.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660172.1">
        <property type="protein sequence ID" value="XP_050516129.1"/>
        <property type="gene ID" value="LOC126890991"/>
    </dbReference>
    <dbReference type="GeneID" id="126890991"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="27883" checksum="CE5E3603D983E0B7" modified="2025-10-08" version="1">MFLGIMHIKGSNALHKKMRKKSLPYGCGFRSPNEDDKRRKEEKRQLEDEKRRLQEKRRLEDERRENDERREKEKRRLEDERRKNDERREKEKRRLEEERRKDDERLEEKERRRREIRNDELKRRREGRNYDEGRQICDERRRYERSNAEERRRYEERRYYEDIHVHEEIGERSYSASNNAEMRSANNGATGTRRQESFALSFRDVEDSIRSFNGKDSHVDYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1C8</accession>
    <name>A0ABM5L1C8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516250.1">
        <property type="nucleotide sequence ID" value="XM_050660293.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660293.1">
        <property type="protein sequence ID" value="XP_050516250.1"/>
        <property type="gene ID" value="LOC126891114"/>
    </dbReference>
    <dbReference type="GeneID" id="126891114"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23739" checksum="0DBEBBBC193B2A81" modified="2025-10-08" version="1">MPHIQVSDSEKLRLYKFIENGSNLELAYRSWEYHEIPLLPQTMKFNWNVKTTSLLERPRFVLFALQTAKKNAIKEDASHFDHCNITNLKLFLNSEMYPYDNLNLNFDKKQYAIAYEMYAQFQQSYYYKVGDPCLSLEQFGSFAPIFVIDCSRQNESVKSGSVDMRIEIETNKNIPVNTTAYCIIIHDRIVNYNPLTNVVQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1H4</accession>
    <name>A0ABM5L1H4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516295.1">
        <property type="nucleotide sequence ID" value="XM_050660338.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660338.1">
        <property type="protein sequence ID" value="XP_050516295.1"/>
        <property type="gene ID" value="LOC126891156"/>
    </dbReference>
    <dbReference type="GeneID" id="126891156"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="206" mass="23165" checksum="DC003C95238DE169" modified="2025-10-08" version="1">MRDSFLSLTDDCLNWSWPSINTWSSIHSFHVHPILWDSFDRINTQTALNTFESKTETQKRKLAHLITQQLPKPRTLKPTTVVHNFSDTPISTIATQALAKGFNYSVTPSHTPIETIICQTEEAISHLPSEDAEIVRQDVARVLRNSKPPTPNISQSERKALKELQANPDLVILPADKGNATVILNTSSYIDKLSNLINTPDYKPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3K4</accession>
    <name>A0ABM5L3K4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517022.1">
        <property type="nucleotide sequence ID" value="XM_050661065.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661065.1">
        <property type="protein sequence ID" value="XP_050517022.1"/>
        <property type="gene ID" value="LOC126891788"/>
    </dbReference>
    <dbReference type="GeneID" id="126891788"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17743" checksum="0E7B7C965BFC1EDB" modified="2025-10-08" version="1">MVKDVAPDFKPMRIFCDFEIAAILAIQEQLAETAISGCFFHLSQNLQRHMAQLGLRSQYNNEADFSVHVKMILSLAFVPINRIDDALDHLYATLPLDIQELLNYFEDNYVGRPNRRGGGRRQPLFPPEIWNLYQRVRDDVDRTNNHAEAANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L406</accession>
    <name>A0ABM5L406_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="13"/>
    <dbReference type="RefSeq" id="XP_050517165.1">
        <property type="nucleotide sequence ID" value="XM_050661208.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661208.1">
        <property type="protein sequence ID" value="XP_050517165.1"/>
        <property type="gene ID" value="LOC126891873"/>
    </dbReference>
    <dbReference type="GeneID" id="126891873"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1068" mass="118354" checksum="D230E20877F3C346" modified="2025-10-08" version="1">MSLIDGRPAQYGITLKELRNLMEHRGADGLEKIRELGGMQEICKKLYTSPSEGLRGTQIDLDHRRETFGSNSIPAKPSKTFFRLILTALQDVTLIILEVSAIISLLLSLYHPPEGESDDETNYGWIEGLAILISVIVVVLVTAFNDYSKEKQFRGLQNRIEGEHKFAVIRLGEVKQISVTEIVVGDICQIKYGDLLPADGILLQSNDLKIDESSLTGESDHVKKGEAFDPMILSGTHVMEGSGKMLVTAVGVNSQVGIICTLLGAAGDQKERRKKKKKNGENKTEAESSHVDTDKKDKGLAREEEVDEASTSAPSGKVTGEQCKRPTEKKSKKEKSVLQAKLEKLALQIGYAGTFIAALTVVILVLQFCIKTFVIKRQPWNYGYANYFVRYLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEQLWKTTPKFNDIATNVGNIIIQAISINCSYTSRILPPERGSNLPRQVGNKTECALLGFVLGLRKDYQIIRDNQPEETFTRVYTFNSDRKSMSTVIPRSGGGYRLFTKGASEIILEKCAFIYSYDGRLQKFTQDMQKRLLRLVIEPMASNGLRTICLAYRDFVRGAQEMNQVYIEREPNWDDEKYIVNNLTCLCVVGIEDPVRPEVPAAIRKCQRAGVTVRMVTGDNLNTAVSIATKCGIVKPNDDSLILEGKEFNRRIRDSSGEVQQHLIDQVWPKLRVLARSSPTDKYILVKGIIDSELSACREVVAVTGDGSNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSIAKFLQFQLTVNTVAVIVAFTGACAVQDSPLKAVQMLWVNLIMDTLASLALATELPSEDLLLRKPYGRTKPLISRTMMKNILGQAIYQLVVIFGLLFVGDKLLDIESGRGVAIGHPATQHFTMIFNTFVMMTLFNEFNARKIHGQRNIFEGIFTNPIFYTIWIATCIAQVGIIHVGGIAFSTTSLDRDQWFWCVFFGVGTLLWTQLLLTLPTSKIPKIFSWGRGNPEECVRAIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4B1</accession>
    <name>A0ABM5L4B1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517273.1">
        <property type="nucleotide sequence ID" value="XM_050661316.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661316.1">
        <property type="protein sequence ID" value="XP_050517273.1"/>
        <property type="gene ID" value="LOC126891961"/>
    </dbReference>
    <dbReference type="GeneID" id="126891961"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34090" checksum="1AC95F6910011941" modified="2025-10-08" version="1">MAVMGINVKLPPDFDLQDQNAASEWKFWKTSFEDYLLATGQDQSADKMKMSILRNIIGAESAKIMSTFEIPEAENNKYDLMISLIDKYVNPRMNESFERYNFIMRVQKEGESFEQFLTSCRHLIRTCNYNEIDPEQTAEDKALRDKILMGIRDPVTREALLRVDKLTLQKAIEFCRTSEQSKNQNLKFYTERKDVDIGEVRKDRYQGHRNYNNSRSKANTNEKFKCKRCQSTHGARECPAYGKKCKKCGLLNHFAKSCRVKNIDVIDEDSSDGSADSFVGNVNKVYQNISKGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4C2</accession>
    <name>A0ABM5L4C2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 223</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517280.1">
        <property type="nucleotide sequence ID" value="XM_050661323.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661323.1">
        <property type="protein sequence ID" value="XP_050517280.1"/>
        <property type="gene ID" value="LOC126891963"/>
    </dbReference>
    <dbReference type="GeneID" id="126891963"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026100">
        <property type="entry name" value="Tmem223"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14549:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25793" checksum="FAE4C18E50BA845D" modified="2025-10-08" version="1">MLKYLSICRNSSKQWTFFNTFNKYSPPRQTPIQRKFSEKALDVNTNVVKDVILYKYDNSRYYKLMNLFAFAQFGFWTYLSYTAYTTLKDAPVDPSKGEHWWKKINLGENKYRNGIALCTGLIGWGILAVVWMYSLRSIKYIILRKGGKQLTIVTYTPVAASRMFTLQLNNISSVDSRSTAKTHIALKVKGHFMYYIVDMKGEFKNPLLFDHTVGIRRNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4J3</accession>
    <name>A0ABM5L4J3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">IFT80/172/WDR35 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517357.1">
        <property type="nucleotide sequence ID" value="XM_050661400.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661400.1">
        <property type="protein sequence ID" value="XP_050517357.1"/>
        <property type="gene ID" value="LOC114330177"/>
    </dbReference>
    <dbReference type="GeneID" id="114330177"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="9">
        <location>
            <begin position="629"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1743" mass="197483" checksum="E282A81B303991AE" modified="2025-10-08" version="1">MTMQLKFLQTILEAQDSDFKIAGLSWSPNNQKLAIATSDRQILLFDEKGEKRDKFSTKPYDPEAGKRSYIITGIAFSPDSTKIAVAQSDCIVYVYKIGEKWGEKKAICNKFPQPSPVTCIIWLLTGPIICGLVDGKVRALQTKSNKSQSLFASDSLVVSLASNPKGTGFLSGHVDGNVIRFFITNDHNDDEAQGRVALHSVPPYGLAWTQGHIFMAGCDKRVSVVNNLGKNVKTFDYSKDGSERDFTVACCSPSGQAVAIGSFSRLRLYTWSTRKTIWEETTPKELTDFYTITALAWKRDGSKVTCGGLCGAVFMFESVLKRIVWKDKFEITYVGPSQVLVKPLDTNERGVILRSQYGGEIEDVKIMGKDCYLVARTEETLLVADLLRNLLSEVPWNNSGHNEKFYFENANVCLVFNAGELTLIEYGDNDVLCSVRTEFTNPHLISVRLNERNQTTDNKKLSYLLDLKTICIIDLVSGVMLAQIGHDSKIDWLELNEMGNKLLFRDKKQRLVLIDVITQLKQTIFTGVSFVQWVESSDVAVAQSGTNLAIWYNIDLPENPTLMTVKGDVIDIVRNNGKTEAICVDGNNSFNVELDEGLVEFGTALNDNDYNRAILFLESMNNTSEAEAMWHTLYLIAMKQQNLKLAERCSTALKEVATAYFLHETSKEAQSFVEKYKETSNNSPEVWARLSILYGDLNTAENIYLEQGNIEKALDMYKKLHKWDEALRLADQRSYEHVKELKEEHMSLLMQSGQYEKVGQVLENEGKSEEALNMYLKSNKLLRIPNLLSKYPQLLNDHSVIGGVLKSLIKQELYEPAAEIYEKLDKPDLAMECFRKGKVWNKAVDLARTVSPEKVVQLEEEWGDSLVESKQMDAAISHYIEAGCMLKALNAAVSARQWKKAVHIIKVIDDADTVKKYYEIIAEHFASVKEYSTAEKLYAACGMYKEAVDMYNEAGQWEKAHAIASEHLDTEEVYDMYIKHAEALEEAGKYREAEKLYLSVNTPDLAIAMYKRVEQYDNMVRLVERYHPNLLQTTHLHLGQQLESQGKYRAAEIHFLAINEWKAAMNMYRTLGMWEEAYRVAKQNGGPNAANQVAFLWARTLHIDSAIKLLNKYGILEPCINYACETYQFEFAFQLCKNLPNKVSEVHLKYAMALEDDGKYAEAESEFIQAAKPKEAILMYVHAQNWINALRIAEKHEPDAVPEVLQAQAGQCFKDKQFSEFEVLLLRAQAPELIVQKYKSEDMWIDALRVCKDYLPHRYPSLQSEYSSSHHNQMTDINIETLLSRANEWALAGQHKQAVDCLLQVNTSITEPSIVKRALLRAADMVNKFLFGDEALEVIKVLSPRLIEIGEHNVAAQLYASMEMIKEAIDAFIVAEEWNKARKVAKELDPAFENYVETKYKDRLLKKGDVEQLADVDIIGALDLLAEQGQWSRCIEKAKSHTAPILHKYVALYAAKLLKDQLVTEALQLYFTHGAPAMPQNFNIYNHIATKMFGANFMSDPDSYGTWEQLRQVMFEINENLEVAINVNPETKVHFRNLLLVSHFYALRSACRQVPSLKVIAVKISTAILRYTDFIPADKAFYEAGKDLKEEGRLSEAFVFLNHYLDLCEAIEEDEGQLVDHSDLVQTDFPSNIPLPHQLYLIEDPKEHDNIKEWVLAISMDQKIEQALPVDDRDLYESSLQPGETPCLITGYPVRKQAITFAKTNLQANKDAWNKLNMGAKMAPDSNVASAISFIVKWCGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5N6</accession>
    <name>A0ABM5L5N6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517751.1">
        <property type="nucleotide sequence ID" value="XM_050661794.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661794.1">
        <property type="protein sequence ID" value="XP_050517751.1"/>
        <property type="gene ID" value="LOC126892293"/>
    </dbReference>
    <dbReference type="GeneID" id="126892293"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="675" mass="78262" checksum="D50ECA14E45786E5" modified="2025-10-08" version="1">MFNQSEVKQEDGVTTCKTEIDNEVDAFPEESFKIEIKDEPIRESSKDTFDYLAVKKCLIKAEIEQDDGFSCKDMKTDADSQLTDHGRSDNTNVNTGGQRFICIICKKPLSNNYRLKLHMRIHTEEKSLECETCTKKFSTKDKLKAHMTVHTGKKPFGCKICTKQYLTKHTLKSHMTRHTGETPFKCAICTKKISTKGNLKAHIMAMHTDENRFECAICTKKISTKGNLKAHIMAVHTDEKPFECELCAKQFPTKHTLKLHMTRHTGEKRFECELCTKKFSTKRGLKVHIIQVHTDEKPFGCEICTKQFSTKHTLKRHMRVHTGEKPFDCELCTKKISTKRGLKAHIIQVHTDEKPFGCEICTKQFSMKHDLKRHMIVHTGEKPFECEICTKNFSTKIGLKAHIIQVHTDEKPFGCEICTKQFSMERDLKRHMRVHTSEKPFKCEICTKQFSRTDLLKAHMTVHSDQKPFGCEICTKQYSTKNSLTSHMRVHIGEKPFVCEICTKQFLRKGQLKIHMIVHTGEKPFLCEICTKQFSSRQVLKSHMRLHTGEKPFDCEMCSKQFPTKQHLRLHIRVHTGEKPFGCEICIKQFSSRQVLKSHMRVHTGEKPFDCEMCSKQFPTKQHLRLHIRVHTGEKPFGCEICIKQFSSRQVLKSHMRVHTGEKPYMDVKFAPNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6P7</accession>
    <name>A0ABM5L6P7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506334.1">
        <property type="nucleotide sequence ID" value="XM_050650377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518109.1">
        <property type="nucleotide sequence ID" value="XM_050662152.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650377.1">
        <property type="protein sequence ID" value="XP_050506334.1"/>
        <property type="gene ID" value="LOC126884447"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662152.1">
        <property type="protein sequence ID" value="XP_050518109.1"/>
        <property type="gene ID" value="LOC126892587"/>
    </dbReference>
    <dbReference type="GeneID" id="126884447"/>
    <dbReference type="GeneID" id="126892587"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="669"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="87291" checksum="C9C0766008F4FFAF" modified="2025-10-08" version="1">MDSTYPSTSTSSLPGACHLCSKIFKNVELRNRHIKRIHKTDVPPRANNKMNQNHIICPLCDQETNFESHEKLRKHLQDCHQLSIELITFEFSSKQEYDTWKDMQKIETSYACSRTIRGKEHKIMYYDCNRSDIHGYKPNYKIRTEKSGGSIRIKGVCPSRLACKLRDQGQVSVSYWKTHVGHKEELRTMHLSKAEEKTVVEKLMAGVPPTRILKDSRKLEVPQLDRLAVITSQDLRNLTRKYNIHKKRDQNDMIAAALKVQEWNANNKNYAFLFKKEGEDHDILRKEDFAVGFMNAVMEEKLLEFPNIICVDGTHGTNKKGLDLTILLVKDDRNAGFPVAFLLSNRLDQRIQEVFLDALKNKIQTEVNAEYFMSDDDPKYYNAWKKIMRQEPRRLLCTWHVVKNWNIRGKKKLQDPTLKAQMKNELRQIIREPDEDKFKELCDKYVSKLEEANEIEFVDYLKRQYLAEHRKKLWPYCYRRNAGINTNMAIESLNNLLKTNYLKRNAAVGIEKLLDTMDELVEEKMWTRIVDIIRPSANNYQDRLSIRAHKRAASMKGKLEELVKETAYGHYEVKSFKGMNILRYVNFRQVCESECKTLFCRVCKICIHRYWCSCDDYMVRNTLCQHVHLVRMYEERLGSNSVVDDAARCLGEMSTIKSRHEEEINEFVRGKLEQTNVTQEKTKRSLQQEYLINVLNGLDDQGFTEFIRRTQGILEEVNNKAKNITKKRKMETQEYFPSKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7F3</accession>
    <name>A0ABM5L7F3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518368.1">
        <property type="nucleotide sequence ID" value="XM_050662411.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662411.1">
        <property type="protein sequence ID" value="XP_050518368.1"/>
        <property type="gene ID" value="LOC114326112"/>
    </dbReference>
    <dbReference type="GeneID" id="114326112"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="124" mass="13928" checksum="2491087922F6ED89" modified="2025-10-08" version="1">MLSSERVGHYCAIIMRSCAAINCRNSVSNCSYGFFRFPKDESRAERWVLAAGREDLLQSIGTLHITHRLCGAHFEKKMFIVNDTRKTLLFQAVPTLFPCLEGSTSSVLTDHSYCSFLDATNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7S2</accession>
    <name>A0ABM5L7S2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Alpha-mannosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050518488.1">
        <property type="nucleotide sequence ID" value="XM_050662531.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662531.1">
        <property type="protein sequence ID" value="XP_050518488.1"/>
        <property type="gene ID" value="LOC114332056"/>
    </dbReference>
    <dbReference type="GeneID" id="114332056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044984658" description="Alpha-mannosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="11">
        <location>
            <begin position="359"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116619" checksum="3F95C322897985BD" modified="2025-10-08" version="1">MRCLLLFLGLTLSGVLSRQLKNYGYQVGCVKCHPVDKDKINVHLIPHSHDDVGWLKTVDQYYYGMNTSIQQAGVQYIITSVFEALLDNEDRRYIQVETAYFWKWWQHQSPEVRKLYKGLVDKGQIEMVNGAWSMNDEACANYQSTIDQFTWGLRTIDETVGECGIPTVGWQIDPFGHSREQASLLSQMGYDGVMFARLDHDDKTNRMSKSALDFVWKGSDNLDESTIFGSIFPTSLYFPPDGFCWDYKCTDGTVDDNSESADYNIDFIRDKFTKLIHTYKQYFPTKNIIIPMGGDFHYESAEKNYINMDRFIKAFQNDTNLNVIYSTPSCYIKAVNDGLDKDLIAKTDDFFPYSDSDHSFWTGYYSSRPNSKRFERVGHNILQATKQLFAQNSYNTSRNYDENLRHLREIMGIMQHHDAITGTEKQHVANDYVRGIHRAITDVEKEMGEVFDELLNTDLKLELASCLLTNVSICKVSQESDKFVVAVYNPLGWSVTHYVRLPVDNGDYMINEGELYDLIPTISNFSHVKIKGETPSAFELVFAAKDIPPMGFKLYYIQKTSATRDAKQEEEGDSDDITTFVMNDNDNTLQSVILNDLNMDITQNFYYYVSDDGNSSGVASGAYIFRPVAPGTANPVSPAQINKIFQKSGKVVDEVHQVWTSEEAEILQIIRHYKNESYIEFDWIIGNINITDNKGKEFISKYTINSNFNNNNVFYTDSNGRELIKRVKNKRSDYTYDPEVEPVSSNYYPVTSRIVIKDEDQDIEVAVLTDRSEGGSSLSQNELELMVHRRILHDDHKGVDENLNEIEFDTGVYVRGTHYLVIGKANKVNLDGKSTASLERIIAQQKLIQPWIGLSATNMSYKDLQKSELVYEGLDGSLPENVNILTFEQWINGTYLLRLEHIMEQDDDTELSKSIDVNIAKAFKHFDIKSMAETTLAANQLLSDYQKKTKYTWKTSDLTTKNVKRVEPIEGTPKAVSLSPMQIRTFIVSLKEKDNTSSFGFYVKPHISLGFVFIIIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L973</accession>
    <name>A0ABM5L973_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518988.1">
        <property type="nucleotide sequence ID" value="XM_050663031.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663031.1">
        <property type="protein sequence ID" value="XP_050518988.1"/>
        <property type="gene ID" value="LOC126893086"/>
    </dbReference>
    <dbReference type="GeneID" id="126893086"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="154" mass="18059" checksum="77E961B112FDD0BB" modified="2025-10-08" version="1">MDMFPLLQNEGDEDKEQEITHIVTEHLSLLEETIARYFPSLNVEKYDWIRSPFSTGNTANFQFSLNQEEEFISLSSDRTLKIKFSEVNVQEFWILVQEEYPLLAKKAISILIQFSTSYLCEFGFSSLTNIKNKNRERLLNLEQEMRVALSHIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L979</accession>
    <name>A0ABM5L979_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518997.1">
        <property type="nucleotide sequence ID" value="XM_050663040.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663040.1">
        <property type="protein sequence ID" value="XP_050518997.1"/>
        <property type="gene ID" value="LOC126893095"/>
    </dbReference>
    <dbReference type="GeneID" id="126893095"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="341" mass="39320" checksum="088339F3B6702B5D" modified="2025-10-08" version="1">MEEAGEKERELAIAEGQLDSDGIPWTTVYCDGGWSRRSYGHSYNASSGVFIADGESSVYAKIREEVPYGQYVTKIECCNHAIKNYGKALYKIKADTTVNKEARALLTNNKIKELQNCCTKIINTAAYSDVENLKSNLQKSIDHVFGNHAMCSDQYCTEQQSDAHLMTSVKNTGLYFHINGSLQRLISKGHRLIDKETNNRAEMYMSILCKFNAGKRLNLSGRGSFRCRSAISGLRYNEGVEWQEKEWRSILKRSPGKYFKRNIKQNQRAVELKSKRKLDFVSHYRKKRRRAIKNNTDYGPHALQPALTENEYQSEHSRILKTIQVNFRFLYFVMKINLMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA66</accession>
    <name>A0ABM5LA66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519336.1">
        <property type="nucleotide sequence ID" value="XM_050663379.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663379.1">
        <property type="protein sequence ID" value="XP_050519336.1"/>
        <property type="gene ID" value="LOC114334231"/>
    </dbReference>
    <dbReference type="GeneID" id="114334231"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="1281"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="1906"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2725"/>
            <end position="2773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="3962" mass="455208" checksum="6C72544DE77CF007" modified="2025-10-08" version="1">MFLSKIVLQFEDQTVKKTNQKLADVMNQNEWIDKFRHTKDGSFVYLTYAVPSSHELFYPYALRVVPYKLVDKSNFFTMSAKGVMQHVNSETIFTSLDKWENEYKMYCRLMEIKLFLYFRKWKGFYFWRTKIKRKKIYNAKRMLKDNLLSLNPILRQGLLAVQDMCYKMIDVSFTDVSQIENTWLFYFVEDQMEKFHQIMIKIEEYHTVAKEVISSACHGALLARGFVVDERIIAEESQKERKRKVHKASYIEQAAKKKFCERLSSFIILTDYITINMLHQLITNSLNALLKVLDAHTQFLPTEEQLDNFEPMALTLPRTDDTPKLPWFVIYVKVLPDELLLDPSLDITLDMFNQMITLWEEKTKGIKSFVGDSYYYPFTNPIINEKVEDRICGWGPTLEFYLSKDVHLAKKKSDLIDYFRKNYDTAFSYLRRYQGIREFYADDILVKDKDIENERDLETFRMLCTRYHDQITTIESILPAQEMGVLYIQLEGFVETCLPESQKLLGTLELTIPWVGKTKVDALIEESAEIEAFLFKEPTATADYVKYLEYIEQSNVRADEMENIYDYCKELYDIIDEFNINVDNEEVNTYLGLSVTLGNLRNLVDKKMEDTTRLIKLFSDALNKDISALISQVGTIKDECMQPWLYDINSNFAQVMEFLTELFDKLVDCQKRAAEFKEYQKQFRLEVTRFDVLDEVMNDVKLRILLWDSVDSWAKTVDEWYHIPFDTLDVDEMNMFIAKNLKYIAQLEKGLPVNLIVPKFRDEVELMKDKLPVVCYLRNPALKNRHWILVENLLNHKFKPDETMTLELLETLGVFNNPAELMEISGQASSEAGLEALLKKVEEAWKTLELPIISHKDAKDLFILGSLEDVQAVLDESNINMTTIASSRHVGPIKPRVDEWTKNLDLFSRTLDEWTSCQQQWLYLEVIFSAPDIQRQLPNEAKLFTVVDKSWKEIMRRTAKMPLAMESALYPNTLEAFLRNNALLEQIMRCLESYLETKRVAFPRFYFLSNDELLDILAQTRNPHAVQPHLRKCFDAIARLEFGVKVPDEPEEVDPKAKDEAPVEVVLTTDIIAMISPEGERVALGKGLKARGNVEDWLGKVEESMVLSLKRLMKASLVHYQTHLRTEWALCHANQIILTVSQIMWAKGVHDILDAPSNVNKVKKMEQYEQKCISDLNDLAKLIRKDLASVPRKVLVALITIDVHARDTVSNIVASKITNSSSFDWLKVLRYYWHESIDDCQTRMSSASYLYGYEYLGAAGVLVITPLTDKCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSEGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKVPRFMFEGREIKLVQKCAAFITMNPGYAGRTELPDNLKALFRPIAMMVPDYALIAEVILYSEGFESSKNLSHKMVQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRAAPDREEDVVLICALRDSNLPKFLADDAILFTGILGDLFPGIDLPVPDYGIFQSTIEEVMVEHNLQPEECMIHKIIQLYETMIVRWGVMLVGPTGGGKSEILKTLNRTLTRMHHNGIKGPQFRPVRTYTMNPKAITAGELYGEINPFTLEWKDGLMGITMRTAVGFTTEEHQWIICDGPVDAVWIENLNTVLDDNKMLCLANSERIKLTEWVHMVFEVQDLSQASPATVSRCGMVYVDSEEIKWFPYVKSWMANFSEALLSQEMKEFMLELFDHAVENGFMYVKKHSHYSIHQVDVSKAKMVCSLIESFLKMPGAMDKIGEKSKVRTFLCQTFILCYLWGVGGNLLDESREKFEIKVRDQFDEHPDSKIQASADLWDLYMDVVSHRLELWAKIIPVFKYMPELSYFETLVPTIDTVRFGYIMERLIYVDSPVFITGETGVGKSVVAKDCLHRLFLTQKFVPATINFSAQTSSARTQEIIELKLEKKKRTLIGAPVGKKVVIFVDDVNMPKLDTYGAQPPIELLRQLLDYGGLYDREKLFWKDIRDVVITVACAPPGGGRNPLTPRFVRHFGMLLIPPPSEVALKVIFKSILRGFLNPFTNEIRDLTEYMVNAAVDIYQRIESDLLPTPAKSHYVFNLRDLSKCIQGITQADPGSMRTEVDMLRLFYHECLRVFHDRLINVEDKSYFYLLMKDICVRNFGSPVLDLPEGEIIQNPPILLFGDFIQMGAEKKNRVYEELKNIDKLKNVLQDYLDDFNLTTAKEMKLIFFMMAVEHCIRIARVLRSERGNSLLVGVGGMGKQSLTKLAAHLNVYKCFQIELTRNYDHMSFFEDLRKMCFHAGVEFEDSVFLFTDTQIVKEEFLEDINNLLNSGEVPNLYEAEEYEHVIIGVRGAAKVAGIDEANRDGIYDHFISRVRIKLHLVICMSPVGDAFRRRCRMFPSLVNCCTIDWFEKWPQEALLSVAESEMISLGEDISTRLARVCVAMHESVEVMTVRFYEEMKRYYYTTPSSYLELIKLYRSMLGMKKDQITKTRDRINNGLKKLYETNSVIDSMKETLTALEPVLAQKSIAAEELMVFLSKEQKQADTVRTIVKADEEVAKVKAEETQAIADDAQKDLDTALPALEAATKALESLNKNDINEVKVFQKPPKLVQVVMESVCLLLGAKTDWASAKIVLSDAHFLKKLQEYDKDHVSDLVLRKLKVYIENPDFVPDKVVKVSKACKSLCLWVRAMDMYAKVYRVVEPKRKKLQTAEKELAQVMALLRDKQMKLAEVEAQIANLEANFNATMAEKKAIEDNIELTAARLNRAGRLNVALGDEQSRWEESVERFGIELENAVGDVLMAAACVAYLGAFTSNYRMELVNIWERKCHGEQIPAAQNFSLITVLADPYEIRTWNSCGLPRDNISTENAILVKQAGRWPLMIDPQEQANRWIRQLETENQLKVIKLTDSNFMRTVETAVTIGIPVLLEEVEEALDPTLEPILLKQTFSQGGRLLIRLGESDVEYNEHFRFYITTKLANPHYLPEICIKVTIVNFTVTLSGLEDQLLADVVRLERPDLERQRTELIIKINADKSQLKAIEDKILYLLYHSEGNILDDEELIETLNESKETSAIIEARLIETESTEEKISVAREKYRLVAVRGSVLYFVVANLADIDPMYQYSLKYFNQVFNTVIEVSEKKEVLEQRLAILIKEITKAIYTNISRGLFERHKLVFSFMLCVAVLQQSGIVTDAQWNFLLRGPVATKTAIPKKPDNPVITDAMWSAAYFLSSTYEHFEGLDVDFLKRIHLEIGDFKLDIRLVDPKKGPADSRRDWNTQLDDFDKLMLIKTVAEEKLIFAIAEYVKIKLGKTFIESPQISLSVLYEDTTNGVPLIFVLSTGSDPFEAFQRFANEMNFGDRVKSISLGQGQGPVAEKMIQEAVEKGDWVFLQNCHLATSWMLAMETIVLAIARDTEKVHKEFRLFLSSMPSKAFPVSVLQNSVKVTNEPPKGLRANVKRAFTDMDKNFFEHHHLEHQWKAMIFGLCMFHAVIQERKKFGPLGWNIVYEFNDSDRDFAFNSLKMFCVEESIPWDALEYLTGEITYGGRVTDYWDLRCLKTILKIFFSPKILTSGYVYSESGIYYCPVFLTIQEYREFVDNLPIIEQPEIFGMHENANIAYQVKETNIIVRTIMECQPRTGGGVEGRSSDDIVYDLAEGILTYIIKKIPTEHVNAYMFKKDKKGRVPSLTTVLTQEIDRYDKLLKMIHESMEQLQKAIKGLVVMSDALEEIFTAFINNTVPGMWNRIAYNSLKSLGSWTRDLILRLDFISTWVRYGAPTSYWISGFYFPQGFLTGSLQTHARKYNLPIDELKFDFYIYKQMLDQEDIYNKHIVVGKEVYESYKLYEVPTDGVIVHGLFIDAGRWDLTIDELVDARPGEINPPLPIMWLQPTRTLPPNDTRYAAPLYKTSVRAGVLSTTGHSTNFVIAVFLPTRYPQEYWILKGTALLTQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYM7</accession>
    <name>A0A6P7EYM7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ninjurin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114324443</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128101.1">
        <property type="nucleotide sequence ID" value="XM_028272300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYM7"/>
    <dbReference type="FunCoup" id="A0A6P7EYM7">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272300.2">
        <property type="protein sequence ID" value="XP_028128101.1"/>
        <property type="gene ID" value="LOC114324443"/>
    </dbReference>
    <dbReference type="GeneID" id="114324443"/>
    <dbReference type="KEGG" id="dvv:114324443"/>
    <dbReference type="InParanoid" id="A0A6P7EYM7"/>
    <dbReference type="OrthoDB" id="6114058at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF17">
        <property type="entry name" value="NINJURIN C, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028128101.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18705" checksum="0C022F653FFE608B" modified="2020-12-02" version="1">MGNMSQKDSKVNVAGQNHQTHHTHRDGNVISEILRSTLDVNKYATKKTIAQGLLDIALLTANASQLKFILQVGEEHQFYLLMLILISTSIILQVIQAALCVILGGSYDINKEHHQDNANKTNNIIMVVNIVIMAVNVIINSFEMKSEYLINMFHAAKTSTTTIASTIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F003</accession>
    <name>A0A6P7F003_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC114324891 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114324891</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128591.1">
        <property type="nucleotide sequence ID" value="XM_028272790.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128592.1">
        <property type="nucleotide sequence ID" value="XM_028272791.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518821.1">
        <property type="nucleotide sequence ID" value="XM_050662864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F003"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272790.2">
        <property type="protein sequence ID" value="XP_028128591.1"/>
        <property type="gene ID" value="LOC114324891"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272791.2">
        <property type="protein sequence ID" value="XP_028128592.1"/>
        <property type="gene ID" value="LOC114324891"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662864.1">
        <property type="protein sequence ID" value="XP_050518821.1"/>
        <property type="gene ID" value="LOC114324891"/>
    </dbReference>
    <dbReference type="GeneID" id="114324891"/>
    <dbReference type="KEGG" id="dvv:114324891"/>
    <dbReference type="OrthoDB" id="8192147at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028128591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028128592.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30153" checksum="0A9185F7BF54F646" modified="2020-12-02" version="1">MATKDRSLGSGISIPQWMKTKSSKFDLDPSTFSPTELDDSFMLYYRRPKPESNFSTTTTITTTNLPENITVATVTKKKQDFSQHPVPCQKYLRSGQDVPPQTSSEMKIKSPGTDDGFKGEAAKCGSSIIKVASQMISNQGLGLRTCYPVEPMEEKYDGTRRRNSKSLPASPLTSPGSSPKAHRRVNKYFTGAFTDVDKSKGSWILSNLYAKREISQSVGQIKEEGKEDLERTSSAVSLSEQQQQPIKTTPPVFRAKPSELREMNFWSPTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5D2</accession>
    <name>A0A6P7F5D2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane emp24 domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114324938</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128660.1">
        <property type="nucleotide sequence ID" value="XM_028272859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5D2"/>
    <dbReference type="FunCoup" id="A0A6P7F5D2">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272859.2">
        <property type="protein sequence ID" value="XP_028128660.1"/>
        <property type="gene ID" value="LOC114324938"/>
    </dbReference>
    <dbReference type="GeneID" id="114324938"/>
    <dbReference type="KEGG" id="dvv:114324938"/>
    <dbReference type="CTD" id="38698"/>
    <dbReference type="InParanoid" id="A0A6P7F5D2"/>
    <dbReference type="OrthoDB" id="10037706at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027680392" evidence="11">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028128660.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26907" checksum="C334F0F8C339F951" modified="2020-12-02" version="1">MGLSATLLLEISFVVLCFLQYSVQQVTPPWYENLPAVAMDYKVYINPGKEDCYFQYVNPGATFYVSFQVVRGGDGMAGFAVRHPNGQIVHPYQWQASSEYQDQQSVGGYYSVCIDNQFSRFAGKLVNIYMTVVRYDLWESYTKEIESLNMNMENFTSTIVQVEMNINNMLQYQHHSRAREAWDFNLLKDNNSYVIRWSIIQIIVIFATTCIQIYFVRKLFDIKTGGSSRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9B7</accession>
    <name>A0A6P7F9B7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114326171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326171</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130228.1">
        <property type="nucleotide sequence ID" value="XM_028274427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9B7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274427.2">
        <property type="protein sequence ID" value="XP_028130228.1"/>
        <property type="gene ID" value="LOC114326171"/>
    </dbReference>
    <dbReference type="GeneID" id="114326171"/>
    <dbReference type="KEGG" id="dvv:114326171"/>
    <dbReference type="InParanoid" id="A0A6P7F9B7"/>
    <dbReference type="OrthoDB" id="6628848at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028130228.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30187" checksum="8563FC7290C2F3B5" modified="2020-12-02" version="1">MTDGNTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYIVANLDTAYILEVRDIIVSPPATERYAKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAARTQISEASNALESTIEKLTAELAEMKIHLSSLSNAQAQANTYHRNRSNSRRRPYPRDSSYSREHNSDILCWYHYSFGDQAQKSSPQCKQQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAP4</accession>
    <name>A0A6P7FAP4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enhancer of split malpha protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114328073</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132626.1">
        <property type="nucleotide sequence ID" value="XM_028276825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276825.2">
        <property type="protein sequence ID" value="XP_028132626.1"/>
        <property type="gene ID" value="LOC114328073"/>
    </dbReference>
    <dbReference type="GeneID" id="114328073"/>
    <dbReference type="KEGG" id="dvv:114328073"/>
    <dbReference type="InParanoid" id="A0A6P7FAP4"/>
    <dbReference type="OrthoDB" id="8190494at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029686">
        <property type="entry name" value="Malpha/m4/m2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254:SF0">
        <property type="entry name" value="BARBU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12254">
        <property type="entry name" value="ENHANCER OF SPLIT MALPHA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15952">
        <property type="entry name" value="ESM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028132626.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="18206" checksum="5CFD7E521D13566E" modified="2020-12-02" version="1">MSLYDAEVFNNSVNDNKVNDKKSKSTMHQIKKLIKCIIKKNKHTYVKNPQPDYYFDEEISDNLANEILENEIFEDIDNCEDFSAVPVYENGEMDFLPVTRGQRYIPVHFARTEAGTFFWTSITTPDQDICYHGDKNAISNYQVPQRQVPNDRWAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCK2</accession>
    <name>A0A6P7FCK2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC114328012</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028132552.1">
        <property type="nucleotide sequence ID" value="XM_028276751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505853.1">
        <property type="nucleotide sequence ID" value="XM_050649896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCK2"/>
    <dbReference type="FunCoup" id="A0A6P7FCK2">
        <property type="interactions" value="1241"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649896.1">
        <property type="protein sequence ID" value="XP_050505853.1"/>
        <property type="gene ID" value="LOC114328012"/>
    </dbReference>
    <dbReference type="GeneID" id="114328012"/>
    <dbReference type="KEGG" id="dvv:114328012"/>
    <dbReference type="InParanoid" id="A0A6P7FCK2"/>
    <dbReference type="OrthoDB" id="2149267at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04270">
        <property type="entry name" value="ZnMc_TACE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034025">
        <property type="entry name" value="ADAM10_ADAM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF3">
        <property type="entry name" value="KUZBANIAN-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027864084" description="ADAM10 endopeptidase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="23">
        <location>
            <begin position="280"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="22">
        <location>
            <begin position="512"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="801"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="929"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1029"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_028132552.1"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122043" checksum="B4E7773F5BED2D5F" modified="2020-12-02" version="1">MVIRVVCGVLVTCFFGNLLHCSPLDPVKHIKDFNLNSWIRHYEPAQYDPKSLVSQHTRVRRSSGSERGRYPLRLDIQGHNRLFKLRLFPDEELFANDISFESTGGVINFDPTVVYTGNLEDDEDSVAHGLITKEGLFEGTISTASEDYHVEPVSRYFLEESMQKPSFHSVIYKASDVHDPRKGQSCASHRLYLNSNLKNNQNHRKKRWLLEAEAKLPPSYDDPPIIFSPNRTRRPFTPIFDLNQPIDEELEMFTNRSTLDASGLIFRNVNKRATVDPKKTTCMLYLQADHQFFSKYGTEEACIEVMTRHVQRVNAIYRNTDFNQDGKSDNITFMVKRIKVHTLEALKDPLYRFPNNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSMKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCSPGGEDGNFIMFARATSGDKKNNNRFSPCSLKSINPVLNFKARSPKGCFTEPKVAICGNGVVEEGEECDCGWEEDCRDQCCFPMRRYATIDEPPCRLTPRSACSPSQGPCCTSNCQVKFGDKCRDDNGCRDESFCNGRDPQCPPSINKPNKTICNKEFVCFMGECTGSICLAYGLESCQCIPSKSDPKTKACELCCKLPGDTQPCLSSFEWNDMPYDIPDMYSKPGTPCNNYIGYCDVFQMCREVDPSGPLATLRKLLLSDESIASFKKWIIDYWYAVAMIIAAVIALLVLSTKYLGKKPNFKLKSVTIIHKSPTEAVRLPPDGEGVTVHPGVRSKLPLKRKVRDGKMKRKRKGKVESINNNLNSPNKSKVSPKKKKRVSAAVVAEEVKAKPVDTKVFEVPSNKVKRTSQAAKPAKKKKKKNEIIDYSSIQADLDGKKGSDVVHTPLTPESDPVGKVQNWLLKSQYALPKSKSTPVGLTDKTRRSPHKRPTIRPRTDKSKSHSVGNIPSEKEKVRLQVVYKPPFKFSVKLRKPEKTSVIIERVPDVVKKPEKVPPRTGVLVRTIKETESTKPPPPPPQIPLPPIPVNEQSVDVVDHPSSAANIDSNIHTVQSDLEVLLSESEFLFSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEN9</accession>
    <name>A0A6P7FEN9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114327410 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131820.1">
        <property type="nucleotide sequence ID" value="XM_028276019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276019.1">
        <property type="protein sequence ID" value="XP_028131820.1"/>
        <property type="gene ID" value="LOC114327410"/>
    </dbReference>
    <dbReference type="GeneID" id="114327410"/>
    <dbReference type="KEGG" id="dvv:114327410"/>
    <dbReference type="InParanoid" id="A0A6P7FEN9"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028343431" evidence="1">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028131820.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34306" checksum="288C7E35B495D417" modified="2020-12-02" version="1">MWSRSLVSFGIVTLVLHLHCVQGLKDDCDKLGILLYEDVGCTPVLAPGKSCPIKYECDLAIRNNTCLFRGTEISTTTRPTDVDFGSCNVGCFCNKDLPYDPAEIDKMFNNQPYNIPGKFTCAILDCPEWLGAFPLQKDCYRKYKLDQCCADGQMCPQDKPGNCEVDGKTVLEGQRFYPKDTCTHCVCPKNFNGKLEAPHCRRQFCNVQVRKQREVSSYCAPYYSEFEGETLCCPSSWICPSDEQKIITVNPKAEKSADLTCQYGKKKVQLGEGFETTVKGYDNVERAAKCECVIPPFLTCRQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGN0</accession>
    <name>A0A6P7FGN0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 13D isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329221</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134062.1">
        <property type="nucleotide sequence ID" value="XM_028278261.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FGN0">
        <property type="interactions" value="929"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278261.2">
        <property type="protein sequence ID" value="XP_028134062.1"/>
        <property type="gene ID" value="LOC114329221"/>
    </dbReference>
    <dbReference type="GeneID" id="114329221"/>
    <dbReference type="KEGG" id="dvv:114329221"/>
    <dbReference type="CTD" id="55187"/>
    <dbReference type="InParanoid" id="A0A6P7FGN0"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23453">
        <property type="entry name" value="beta-trefoil_Ricin_VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="2407"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="720"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1328"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134062.1"/>
        </source>
    </evidence>
    <sequence length="4089" mass="460965" checksum="D90112538DDF83FF" modified="2020-12-02" version="1">MLEGLVAWILNTYLGKYVELNTDQLSIALLSGKVELENLPLKKDALRHLGLPVEIKTGFIGKIQLQVPVSQIRSAPWVIVIEQLCLVATPLSIDQWDCEAEDLARHETKLAALDSLEAEWRIKRDGQDYNSTYYSSSYSSWYSYGAGVISDIIENLQLRVQDVHIRYEDSVSLPDQTFACGITLGSLIAQSCDQNWLPKFVHPSPNEDSFKILELKEFGFYWMVLNESESLSLLNVAKLAEAMSRNKLEKTTRNYVLPAVSAQAHLKRNRSSEPLRSSMPRYVCDLLLEEVHLSLVDWQYNQIVNCIHGLQDINRLRKYRRYKPMQSVKHDARAWWFYAISCFYPTGKQPSICKPKPTWESCLKKARENVKYVQICKKILAAPSMTLSADEKKIKEEVEWGREYEDLKILKKIVLDSVKLPQLNSNNENDSSKGRSLLVKWFPTWMGWYSGSSETAPTLPPDASKLEGEILQVLADTAEDSTTFRKDAVFGKFNFCLKTGTLGLCTMDKTTNESSSLLEMEFKNFMLGFLSKPRSQSHVIELSLDALFLKDKISANTMFPIVMGPSGIDRISSAQIRGPRRTGTNKSDYVKEHLFYLIYEKKPPNSGTDFRLSVKSESLDIVYQPNVVRWLIEFIYLPIQRDITQIQLEAMKLKTKKELMKNWEQIFSGGSVNRSTWELELDITAPQIIFVEQFSDQNSAMAVIDFGKLHLKNNVEKMSENSKAGALDNKNDEDDETYLTPCSTPPVSEGSLSADQTIEGISEAEDASNILNESNLHKKLYDSYCLDLTDLQILIGRAKDNWRFALNKGSSNLHVLDRFSISLQIERRVIYTSDPHYPSVILNAQLPKLVTHLNENNISSARNLIQMLSMTLLPPSFKTAANTNINSSVDVPDTGQDYENSEPESLHSDIEQNNLITMQFTIDQMSLEIQSRGRSIAELQIAGVKLTFSRRGVEMSIALTVHSLLLVDALQTFGADFELLVASHKHVGMDSMSGSIRDSEPTSPVSPASPDSTSSRNGATSPLALTQALNTLATSPREGLMKNILEVDAEALISIEIQLITGPKPMQIANIQFNNLDIIANQQTLVELMGFFRRVFPETQKSGSLKSHNLAFNAQKSTESLLEETISHIGTTEIIFDFHRLNVLLLRGIVKDGNLYGKKIGTATMSAAKIQATISSKFELEGSLGSLQVLDLTPEGQIHQSILSVGSDPNSDNSHLLYTISDEDKTAFKFRLVKTEEKDALDVMIRMASVWYTHSPYFILELQSCASEFKQYLSNLAKTIRTAATDMALGLVHVRTEALAQSLNLSKNLPNSVYSSAVSISENFTPTRRRSASTSAKDSMISTPTSPNDDSDLILNVNLDVELDSPVIVLPLSNTSTEVFVAHLGKITVNNKYTDEVRIHSVHYRIECYNIDVKDMNIYSLDIKTRRVLDFKCIKPEVFYNCKYDAKPILHDTILQLKIEREVNKPINTYDQEFSLDEDIVKTKKTIQVSGSIVNGLKVSLTRSQYRQILDTLEFLSSINSHSHEDYSRIHARPNFALADIKEEDSGISTLNMDPHVRAKMFQNFPALKKKRLSSSVTEVKICFDISLFKIELKAAEQSLINVSFLDFAFRYDKCHDFETNIQISLRSVLMEDLQQPEDSKHRIIVTSSANSDPSSSAASTASRSCPDVTYPPYLRRTSHNSLPDHLESNDLFGFQDNSTLHKNDTSWEEYPCTPPSSPTGTRSRGERNLVIVSMLLVDTNAPNFHDHYNSVHNATSVDFNCLDLIITSKSWVIVLDFFSLPPEPVSTSSESYEDIRYKPRKEVNVTTINVKSLNIVIAERDREIAKANISNVELEIKTTGSSKEVDGKLGSLSLLDLTVDGQFYRDKFLTSGKQAVLFKYSRYPPGAKKDHDAQLILEMASVVYVHTKRFIAEILAFFKNFAERQQMLIKSIQAATSRQLSRDEPLRLSLIIEAKSPIILLPVSLKSPNLIVVDLGQLVVTNSFKFSGDEGTVSVVSDSTRKKCLLDVMAVSLENTDLYMGVKTNHVGPERKSKSTYFNFGNSCIMKVGPSLLTKKFQLKLQIEQNLDKKEKQVVPDMSIYGQLSTLDAAIDLDQYKQIRGLLAHNLGEDTEHINPSVPPNLRNESDSGRYWTLSFIKLDLQNVTLSLSESHYLQDSHLTCINFIKSHLTIETFSNFCQDIDLVSKEILIKDTRQSKSDEKQNVFSSILQPVSNPTNNEQVQAEIHSRKKLDFMKVTILFNNLRLMGIFDWWERFLKYIGQDFDHGPSEEHEIQKHAKMESSQLEFELKLNITDSEIVIVEDSSQWDTNAVILKSTTVLNYRPFDMFKPLTCNLNNCEMFSCILGLEDETALSIIDPVILNIEVNQNGILEVQLQFFIVRLSYNDMCMFIRILNSLPQQILFSKDDKEEKIGSLASQVALLSGLGFKPEDCAAALEKCDNRLDDAALWLTNAGKSLDTRKPAKKALNISAVEVKANRISLCIIDDCGDSDVPLLELSFTDVHFNQLLPEFNIKDPIYPQGYIDCVLAIDYYNRVLSGWEPMLEPWKCKVNWEQTNSQMLLKYRLSLKVESNEIFNLNITSTVIELFDQVKVNWIRDYRTIAQLKSNALAVDNAANYRRRSPFVPFALKNLTGSALTFTTFVSELDNYSSTPIGTQTENWLNVNPGEIVTFSFTTRDKMRHQNSHKMRMHQIKVKVDGWNCLEPVTVDRVGVYFRDTCAEFQARMSELPYARIVFDVTLEGSARKLVTVRSALQLVNNLPQAVDIKLESKLPSDDITNMFWVASQLFTIQTNETLAIPLTHAHSQINIRPSLSPQLYTFSVPGISWTQVPNGADRIFQLATCHSHKGHNYRFYTEIVKQEVLIPNRIRHEPAHTIFLLPVVAIENLLPVDMRYTLSAQQGIIKTNASTTVHNVDPDSVELKVELDNFRTCNNVIVPVGCTTTFTCRVKLEDNQQRKLHLQVMVSFNKGAKLKFTVSAFYWIINKTGLPLVFRQSGTSLESAGQYDEHEQARMLSPFMFSFSDQDGSPTMNARVGKKVIWDGTPQWCANFHVAKGTQYRKLHVTLRDGRPDVVFIIGLEVRVGRGKYRSTNIITISPRYQLHNRTSYKLLFSQLCYTQGRQQQLPKSCLKAMSNSHMPFHWPNLEKEQLLCVSIEEVQECCWSGGLKIDTNNSMHVNIRDALGGVYFLRMEVVLKGATFFVVFTDADTLPPPMRVDNFSEVSIMFGQSCYIDIMHSTARAHSSVPYAWDEPTKASTIKVIGPGGVSNTYNMSTLGSVPGLTYENFIYIAFTGTFKKSRGVYDPNPDMESQELVLSVGKNTRVLLSSKMASDRSQLWRMTSEGYLEHEGSSPPLHPGQTRNQDSILVLDIENTAPQPNTYSRLMLRRIDPRRQSTQKWRFTEDGRLCCDHYNMCVQAMDGSYGLRSGNAVVLGLPQAVSYMFVSNGLPIEQAIERQYLRPGSGLLSVNIYMDGPTQVICIKDLKESKYYATSDDKEWGTISKDQRPNLIRTESKEKEENRELQFNITLNGIGISLVSRKMQEELLYVLFSHIVGETVITNQANQICFSIKDIQIDNQLIDTSVPVVAYITPPSSRNNDQAYNHLSALDFSAELQPQNNARAVIFKYLIIRLKKITLIIEEVLLLKFCEFLGIHSQTEEIVNKDQDDGEIQTLLSETSAANAKRYYFGIIKLIPDQIRLSVTTASKLPKQLQRIKRKLGLTLIKFEDAAVELEAFERKHPFETSQFLIQTIIKHFNTGLMWQAGIIIGSVDFIGNPLGLVKDVSEGISGVLYEGNVGSLVKNVTHGMSNSAAKITESLSDGLGRVAMDDSHEEMRQKIRTVHSGKSSDHILAGFKGLGFGLLGGATGIFKQVYEGASNDGIQGVISGLGKGVVGAVTKPIVGVLDFASETARAVRDSSRSKLMPQRNRLPRCVFGPGELLPKFNSKQSQGQEYLYRVNNKNYNEQLVAYEILGSASEDLMCIVSNKILRIVTSTKTPELTSVIECHLSDLEVCNVIKEKEHSEIRYYIEIVMRYAGASAALLVNTDPVKKPRVRCRTLELADTISKQINYAKRMYNEHLYTLVTDNSSMLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH35</accession>
    <name>A0A6P7FH35_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC114327992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC114327992</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7 8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132524.1">
        <property type="nucleotide sequence ID" value="XM_028276723.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028132525.1">
        <property type="nucleotide sequence ID" value="XM_028276724.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028132526.1">
        <property type="nucleotide sequence ID" value="XM_028276725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH35"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276723.2">
        <property type="protein sequence ID" value="XP_028132524.1"/>
        <property type="gene ID" value="LOC114327992"/>
    </dbReference>
    <dbReference type="GeneID" id="114327992"/>
    <dbReference type="KEGG" id="dvv:114327992"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028132524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028132525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028132526.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="63641" checksum="040414B48D2F5B33" modified="2020-12-02" version="1">MENKIKVAVCDVRNDVSVEDIQKLVNAGTTYINEIDVTCFSYLYQAVGEGYTGIVRYLLENETYRNIYEGNKLIYLAAEQGHLDILKLLVSSYGVKCLHYSKYNHPIHFAAANGKVLMVECLLEIGTEVNFVDNRNRTPLHKAAQFDDKSTVELLLKNKADIDPKDEYGCTPLHYAVIQNNLPIIDILIEWGADVNMTDLNKRSPLDYAAENNCLEALRLLLKRGANLIFNGKFQSYRTLLIAAQRGLLSVILEFISEGVDINVHSKKGHTLLHAACRAGQFEVARCLLQNGANVNSKSKPNDITPMYFAVTHCQPEIIRLLISYGGLLENPCKNETVLSLAHKEFNSRSHYPDSSRKVCLQIIIKYWLLLSRVPILPPDLNFKYFPHFHTKCREEISLMKFVLIGSSSISVYKFLRNSYQNDNTLVQYLQNEDICRGINIVCRYLKTCEIYSDVCITSEPLYKSGMERRCLLHVSYVYFKTVSPFLPAECWWKIFSCLSNADLKNFIRSFKENFRYIENTCSMDICPPIFLTYEKDSPHPIPFFYLYKRSLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHP4</accession>
    <name>A0A6P7FHP4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114328068 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114328068</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132618.1">
        <property type="nucleotide sequence ID" value="XM_028276817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276817.1">
        <property type="protein sequence ID" value="XP_028132618.1"/>
        <property type="gene ID" value="LOC114328068"/>
    </dbReference>
    <dbReference type="GeneID" id="114328068"/>
    <dbReference type="KEGG" id="dvv:114328068"/>
    <dbReference type="InParanoid" id="A0A6P7FHP4"/>
    <dbReference type="OrthoDB" id="6775882at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028132618.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39080" checksum="8E7BC088247B5345" modified="2020-12-02" version="1">MNFPRYEFCEENKSLLQAFIKKANQCKSNIHCNHKEYNRLSKILPLAPLSDKYGEAKEVITISDSDEDCQNDNEITSLCKTINESLRPLNETVADDITYAIKEILETEKCLNASLISDLHSSKLNLDNIFQQLFKELGYESIIDFGQSLRSNVISNDNIILVYVKYLLLPQLELEYSDRSQENLNEFCNKYSDIVSERLSDHLLICDDKYSRSLLQFVDGLSEQFKVKMFKNLVTNCKNLEDNHISLFDTLQGEQVDNDTLNKLVEIMSKSADKHSTNKNFGKFLLKIIQLVGKNISTFEKPLNHIIGTHRSIWKGKIQKTYDELLQDSFLMSQSLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHY9</accession>
    <name>A0A6P7FHY9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114328232</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132820.1">
        <property type="nucleotide sequence ID" value="XM_028277019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHY9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277019.1">
        <property type="protein sequence ID" value="XP_028132820.1"/>
        <property type="gene ID" value="LOC114328232"/>
    </dbReference>
    <dbReference type="GeneID" id="114328232"/>
    <dbReference type="KEGG" id="dvv:114328232"/>
    <dbReference type="CTD" id="47457"/>
    <dbReference type="InParanoid" id="A0A6P7FHY9"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="11">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028132820.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="19158" checksum="FF2E292C70F118B1" modified="2020-12-02" version="1">MGRRSRSKSPFGSRRRDRDRERDKERDRDRDRDKDKERHRRKRSRDRSRDRERRRYSTERDDHRKYSRSRSRSRSPVDRRRKNKVPDRPLITAADLEGKSAEEQEMMKLMGFCNFDTTKGKKVNGNDVGDVHVILKRKYRQYMNRKGGFNRPLDFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK97</accession>
    <name>A0A6P7FK97_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114330324</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135447.1">
        <property type="nucleotide sequence ID" value="XM_028279646.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510374.1">
        <property type="nucleotide sequence ID" value="XM_050654417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK97"/>
    <dbReference type="FunCoup" id="A0A6P7FK97">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654417.1">
        <property type="protein sequence ID" value="XP_050510374.1"/>
        <property type="gene ID" value="LOC114330324"/>
    </dbReference>
    <dbReference type="GeneID" id="114330324"/>
    <dbReference type="KEGG" id="dvv:114330324"/>
    <dbReference type="InParanoid" id="A0A6P7FK97"/>
    <dbReference type="OrthoDB" id="6136301at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028135447.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="47210" checksum="B4997C7695959862" modified="2020-12-02" version="1">MTILYQSKMCNSEREERDEVDRIPSKDRATNWDVAGFVFSIISHIADVFFDCNVAYRYYANKQLAYFFATLAFIIVPAIINTAFSVRMYVLDPGNANTSTNLTKRFTRKGMCILFVLIFQLAPILRYFDALKYALRSQKAEKNHDVENQRKYYELMVKEDSDVALLRVLECFLEAAPQLILQLAIIFQSHGREMEGKNTFTIVHQLLSIGSSFVSMAWAMASYQRLLRVSLKTKNNVSWAGTFVHFMWHFLVTVSRILCISVIASIYPTETILIIIGHWFLMTLWLACSSGTNDFCNQNSMYDFLFYCILGAVYIFTHVVLVAGPTCCKYVIFYCVLFAENTIANVVWIVSADEELREKVYYLPIILLNVIPFFLGLIFMLLYYKVFHPNLNTGYKPQRTAVVTPESPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FN35</accession>
    <name>A0A6P7FN35_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114332038</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137546.1">
        <property type="nucleotide sequence ID" value="XM_028281745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FN35"/>
    <dbReference type="FunCoup" id="A0A6P7FN35">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281745.2">
        <property type="protein sequence ID" value="XP_028137546.1"/>
        <property type="gene ID" value="LOC114332038"/>
    </dbReference>
    <dbReference type="GeneID" id="114332038"/>
    <dbReference type="KEGG" id="dvv:114332038"/>
    <dbReference type="InParanoid" id="A0A6P7FN35"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF197">
        <property type="entry name" value="FI04477P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="109"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028137546.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33036" checksum="5CE098B2F8922387" modified="2020-12-02" version="1">MANSGNETIVRIEKVLLDIFLMNCVGWPILFLYCWGSAYRRGVFCDDESIRHPFLPSTVPSWTLYITGFGLNILAMSVTEYLNRPTVPRNIVFLGFHIPNWFYNLYCTFGIFAFGAACSQLTTDVLKYTVGRLRPHFITVCAPNVCNGSFIPYKYYENFTCTNPLYIHDKRIMKEMRLSFPSGHSSFSMYSMLYFAIYLQRRMTWDGSKLLKHTLQFLAVLSSLFTAMTRVSDYKHHWSDVLCGLTLGATVSIITAKFFSNLFNPTKELKKSEPSELSALNGNNRTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPT4</accession>
    <name>A0A6P7FPT4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Perlucin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114331401</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136782.1">
        <property type="nucleotide sequence ID" value="XM_028280981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280981.2">
        <property type="protein sequence ID" value="XP_028136782.1"/>
        <property type="gene ID" value="LOC114331401"/>
    </dbReference>
    <dbReference type="GeneID" id="114331401"/>
    <dbReference type="KEGG" id="dvv:114331401"/>
    <dbReference type="InParanoid" id="A0A6P7FPT4"/>
    <dbReference type="OrthoDB" id="7962197at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028339896" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028136782.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18417" checksum="BBF8A3B6CAF86A2D" modified="2020-12-02" version="1">MIRLISLILYFSYLCKTGESCDGDNPKLRYFLGAKKVNWAAAIKLCQTVGMSLVSIQNKEKSDQITQFLESTGVNYDSYDTAIWTSGNRLQDKVNWFWLAREPVRFTNWDTRYNEPNNYGGNEECISILKDGAITTWNDIACNREFYPLCEKSMCCSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQD0</accession>
    <name>A0A6P7FQD0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PHD finger-like domain-containing protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330091</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135208.1">
        <property type="nucleotide sequence ID" value="XM_028279407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQD0"/>
    <dbReference type="FunCoup" id="A0A6P7FQD0">
        <property type="interactions" value="1573"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279407.2">
        <property type="protein sequence ID" value="XP_028135208.1"/>
        <property type="gene ID" value="LOC114330091"/>
    </dbReference>
    <dbReference type="GeneID" id="114330091"/>
    <dbReference type="KEGG" id="dvv:114330091"/>
    <dbReference type="CTD" id="84844"/>
    <dbReference type="InParanoid" id="A0A6P7FQD0"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135208.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12489" checksum="BB5D8746893B89D6" modified="2020-12-02" version="1">MAKHHPDLIFCRKQPGVAIGRLCEKDDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCRECTMQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRL1</accession>
    <name>A0A6P7FRL1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoplasmin-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114333249</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoplasmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138911.1">
        <property type="nucleotide sequence ID" value="XM_028283110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRL1"/>
    <dbReference type="FunCoup" id="A0A6P7FRL1">
        <property type="interactions" value="824"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283110.2">
        <property type="protein sequence ID" value="XP_028138911.1"/>
        <property type="gene ID" value="LOC114333249"/>
    </dbReference>
    <dbReference type="GeneID" id="114333249"/>
    <dbReference type="KEGG" id="dvv:114333249"/>
    <dbReference type="InParanoid" id="A0A6P7FRL1"/>
    <dbReference type="OrthoDB" id="6075101at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004301">
        <property type="entry name" value="Nucleoplasmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024057">
        <property type="entry name" value="Nucleoplasmin_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036824">
        <property type="entry name" value="Nucleoplasmin_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747:SF18">
        <property type="entry name" value="GEO09167P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22747">
        <property type="entry name" value="NUCLEOPLASMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03066">
        <property type="entry name" value="Nucleoplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69203">
        <property type="entry name" value="Nucleoplasmin-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028138911.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18886" checksum="C5D9037C0E2980B8" modified="2020-12-02" version="1">MADEYFFALTLKGKNSEIWDPEAKGAEDYQGGHKLIIKQALLGPEAQEGEVNVVQVEAMTWKDSVKIPIATLKAGGPNNQVLLDLSFPDPPVTFSLIQGNGPVHIVGHHLIGSPMEEFDEMDELEEEMLDDEEGEEGAEEDEDEDEPKAKKAKSATNAKGKTPVKNNSKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUC3</accession>
    <name>A0A6P7FUC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114332823</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138402.1">
        <property type="nucleotide sequence ID" value="XM_028282601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUC3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282601.2">
        <property type="protein sequence ID" value="XP_028138402.1"/>
        <property type="gene ID" value="LOC114332823"/>
    </dbReference>
    <dbReference type="GeneID" id="114332823"/>
    <dbReference type="KEGG" id="dvv:114332823"/>
    <dbReference type="InParanoid" id="A0A6P7FUC3"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Steryl_ester_lip"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027814403" description="Lipase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="70"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="373"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EnsemblMetazoa" id="XP_028138402.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028138402.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45665" checksum="EC4F77EC0F6613E1" modified="2020-12-02" version="1">MQIYFSFIFISVCPLGVFLENVSRTQKLINTVTSNGYPIETHQIETEDDYILTAFRIPHGRNTTSSNNLPIILNHGMLGSADNYIWLGPQRSLAYILADAGYDVWLMNCRGTSYSRKHKSLSPNEKQFWDFSFHEIGVYDIPAVIDYILNATHQSSLYYVGHSQGCTTVFVMGSERPEYNEKIKLAIALAPGAIYKNFNEPWVLWLLKHIPIQEVQMLADELRLYQIPPPYFSEDDVADMATMFCVENKFLKKTCKINMELATRSKVDSVEEEDIPSILSTLVNTISVKQGFHYGQLILSGNFQNYDYGPTTNQEKYNSSSPPLYNFQNITYATALFSGKTDNLVTPQDARLLAKQLPNLVHYSSVPLPQFSHVDFIISKNSKNLIYKPILKLLDRFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVA4</accession>
    <name>A0A6P7FVA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear pore complex protein Nup50 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114331338</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136670.1">
        <property type="nucleotide sequence ID" value="XM_028280869.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P7FVA4">
        <property type="interactions" value="1394"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280869.2">
        <property type="protein sequence ID" value="XP_028136670.1"/>
        <property type="gene ID" value="LOC114331338"/>
    </dbReference>
    <dbReference type="GeneID" id="114331338"/>
    <dbReference type="KEGG" id="dvv:114331338"/>
    <dbReference type="CTD" id="10762"/>
    <dbReference type="InParanoid" id="A0A6P7FVA4"/>
    <dbReference type="OrthoDB" id="10062131at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="436"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
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            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
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            <end position="286"/>
        </location>
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            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028136670.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="61645" checksum="22D01E08556FA785" modified="2020-12-02" version="1">MAGKRGATSDLNHENWDKEEPPEDAGTFQRASEDSLKSRVIKTARRRNPISSVRDGGDGEKKSAFTSFTGFGKAAPPTSTAFSFLSNLAKPNTPPKVNGTGGISEKSKNDASAFKYSSSPITGSGKLNEKVTTNVFGASTANTGNKDNNPTNSPSEKSNEYYSKLKGLNESVSKWIKSHVDANPLINLQPIFRDYEKYFAELEKEKDLKPPDTNNKTDSSMSSFAFKPTTNVPDSTTEKFQSISKNESSKTSENNIPKLTFGTSSTSSATPTFSFGSKASTDSGNKSFSFASTNNEASKTTAAIPSFSFGAKPSISTAVTTSEPAKSISTTTPAFSFGAQQASKEIPSFSFGSKASPVSSPVGSGASTTVPPVSLGTESSAKEATKPIPSFSFGTSMSSSTSAGTTANDTTKTTAIPSFSFGKSVTPFSSATPFTFANAVKPVSTDNKDKDAEEDEEPPTNEFTPVVEKDHVFTTRCKVFVKKEDKFGDRGVGNLYLKPIPDSEKVQMIVRADTNLGNLLLNCILSESIPTKRLGTKDVMLVCVPTPESEPPPVPVLLRVKSSEEADKLLETLNKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVS3</accession>
    <name>A0A6P7FVS3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114334596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334596</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140471.1">
        <property type="nucleotide sequence ID" value="XM_028284670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVS3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284670.2">
        <property type="protein sequence ID" value="XP_028140471.1"/>
        <property type="gene ID" value="LOC114334596"/>
    </dbReference>
    <dbReference type="GeneID" id="114334596"/>
    <dbReference type="KEGG" id="dvv:114334596"/>
    <dbReference type="InParanoid" id="A0A6P7FVS3"/>
    <dbReference type="OrthoDB" id="6784865at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140471.1"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114725" checksum="AD25B4713B14BC36" modified="2020-12-02" version="1">MRTDNIVGGSLKDFKVILRQPFADSTNVNMSNCNETSKEKVVSMKTRLNKSKENKPREQANEKPSAKNHPQKKTVGNKQTNVKSEESNDIKKTTFLMNDFGNKNRLKNELHNSGKAKNSVEDIKQIAHGLGVEKANILISKENINSSSQNYQENVLRIKELSNNKNKKELKVKNSTKTTEVEGKPVNKDKRECKKNLFVNLKRISVSKENEHLDETPEGDAEILSTQKCNKILVVDLINITPKKTNRKNKEAHKSLRKDDTDTSSKDQGKTKNLVVHLANVSPNYINTKDKEAHGTIYTGISSMLQMEDKISSHNMSSCTKATDLSKTTSSNKPLVQNITSRESVPLVKRLRKGINKHYIEESFEDSTLINQTGQNASIVSKNKVPVYKQLVPVLQKPVKDPYEFDVVDTDQDKPRKKKNLNDSGKFNKTMHSFLQKIERKEKKRVKKKPKPVASYDENIQNVLKRVMKKVTEQKSPPLMPNHETNPKMKPVVMKRIQILQEVIISPNSAEIDNSKAESVVQKTVSGSTINFVNISDDFEDGFRGFDNSISQGRESFIEDGFRGFDRSQIHVLNSNSLKDEYFASLNNSSIAQLSEKSLLRENAFRKMMLSSTVPHTSFTSTINQPQNTVGDRNVTSLDANPLDNTRNLHREFHDHISMMADGSCHDTCNNTDFEHSWSDDSEEEDDQYFGFQEVSETTPEKPVRLSNRRKQQPWRLPAIFKRNPYLLKIKQNGLPCGQQEMVIDYEFAKRIEALSANKRPEPAPKPPVQTTMLDFIDSTNEHLERPSEPSLFDYEEFNIVKPRRVLGVLQEHQISTPKKDVGTVLASPNLSVISKPQNIPISTPKRDEQPIMASPNMSIIDKENAEEKVPVRPLQRSYRRLILAKKLQNKSDEDESPKNKNDHGLGNALPSILDNSYEEIPDADIHLFEDVEQDNGVDFSIELPIMKYASNKRKKQVCEGFDADEDKIAKKKKRNMMTKTEEAEFNAWAAKTNARFAEEDKHELTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW01</accession>
    <name>A0A6P7FW01_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin subfamily A member 6-like protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334804</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140699.1">
        <property type="nucleotide sequence ID" value="XM_028284898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW01"/>
    <dbReference type="EnsemblMetazoa" id="XM_050651025.1">
        <property type="protein sequence ID" value="XP_050506982.1"/>
        <property type="gene ID" value="LOC126884791"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FW01"/>
    <dbReference type="OrthoDB" id="8186325at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032134">
        <property type="entry name" value="DUF4816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16086">
        <property type="entry name" value="DUF4816"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027731047" evidence="1">
        <location>
            <begin position="21"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140699.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="44723" checksum="BB6FC0A776D3FA00" modified="2020-12-02" version="1">MKCFLLLVIVGSFLIVPLNSNPVSLSRSKRSFSSQPKGYWSKKLTWKTEWVKVWKQEKKLKWVSEWKKTQVPAWKEVQVPIWKEIQVPDWKVISKPIWKEIQVPAWKEIQVPDWKEVKVPAWKEIKVPDWKEIQVPDWKEVQVPAWKQIWIPIWKEVQVPAWKEIQVPDWKKSYAPEWVKEGIHGEHYLGKDDHGSEYTAHDIWKKKLIWKPVWKKVWRTEKKQIWVPQKKMEWKSEWKQIWKTEKKQIWRTEKVQIWRTEKQQIWIPKKEQIWRTEKKQIWVPKKQLIWKQEKVQIWRTEKVQKWVTEKKEIWKDEWKQIWVPVWKTIEVPAWKKIQKPIWEKVWVSVHVHEDHHGHGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX01</accession>
    <name>A0A6P7FX01_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114331917 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114331917</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137408.1">
        <property type="nucleotide sequence ID" value="XM_028281607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX01"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656343.1">
        <property type="protein sequence ID" value="XP_050512300.1"/>
        <property type="gene ID" value="LOC126888249"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FX01"/>
    <dbReference type="OrthoDB" id="6362401at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF119">
        <property type="entry name" value="PROTEIN LETHAL(3)MALIGNANT BLOOD NEOPLASM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028409265" evidence="4">
        <location>
            <begin position="20"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028137408.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="60972" checksum="E34B6300F9BEF75E" modified="2020-12-02" version="1">MLTKRVFVCLLITLNVIICQKDSDEGRPYEFGFTIDGQQHRHEKKDQNGIIQGEFGFITADGVYHVTVYATDENGNFKILSMRNIRISAPLDGSPALGPISPEASKYLKKAGLPSPAPSAPAAAPSKPLPPAPPKFERIQEAPPPSASTQRAPYVFTTHSTIRPACAGCGLITTPKPGEKFMFQNPAFRNSPEAGVPVPSGPPLLSNSIPNGIIGNGPASLANSGTPDLRSRFSEVAPDAEVLPPGYNNRIVQPSNEKPSPASEKIQSFVSPQQSFGPNFKSQEDSGTLSAISDNGNAGFVRPIEVQGPPSSVIKSNVQSTYQAAGRTTDDGIETFGDVKIAQNRGGKSLGGFSNLPQINNIQNINTQDNGSPQNIRGPVENIDVAGQVETVGNRNINSQENLPNYPQDKFGRLLAPPIGSGPNPLLQPQEVAKLPPVMVSDNVIHVMGKKPIDIAIKDKYPGMVDGLPNGVEVKDVTNILYKFKYTVGFHGHYEKGLKDGSKIGGYFVNGRDGISRIVTYVADENGFRPKFKFINLGLDSPDTPNEKTEKTFGLKDFEFVWYPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2G6</accession>
    <name>A0A6P7G2G6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114336900</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143096.1">
        <property type="nucleotide sequence ID" value="XM_028287295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2G6"/>
    <dbReference type="FunCoup" id="A0A6P7G2G6">
        <property type="interactions" value="1593"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647980.1">
        <property type="protein sequence ID" value="XP_050503937.1"/>
        <property type="gene ID" value="LOC126882908"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G2G6"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="759"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="627"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028143096.1"/>
        </source>
    </evidence>
    <sequence length="876" mass="98121" checksum="0B18AC1840BE0C51" modified="2020-12-02" version="1">MYPYYESDWSVLPPEANRRFNPAFNMATIKQVVNEAIERVRMPTPMRLRDLIRQIRAARTAAEERSVVNKECAYIRSTFREEDSVWRCRNIAKLLYIHMLGYKAHFGQLECLKLIASSRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSATQFVVGLALCTLGAIASPEMARDLAGEIERLMKSPNAYIRKKAALCAFRIIKRVPELMEIFLPATRSLLSEKNHGVLITGVTLITEMCENSPDTLNHFKKIVPNLVRILKNLILAGYSPEHDVSGVSDPFLQVKILKLLRVLGINDVDASEAMNDILAQVATNTETSKNVGNTILYETVLSIMDIKSEGGLRVLAVNILGRFLLNNDKNIRYVALNTLLRTVHVDTSAVQRHRSTILECLKDPDVSIRRRAMELSFALVNSQNIRTMMKELLTFLEKTDPEFKAQCSSSIVLAAERYSPNKRWHLDTLLKVLVAAGNYVRDDVISSTIQLISDSTSQQAYVSIQLFKALSEDLQNRQPLTQVAVWAIGEYGDLLLQGTQDDENGVTVPTEEEVIEVYQRLLWSTQNTVMTKQYTLMSLMKLSTRFNSTHNKIQQIISSFCSSLHVELQQRGVEYSQLFGKYSHLRPALLERMPPMEITRTQTENQTNGDISDSEPRSNEDSPQHNVNSDSNALLDLLGGDSGTDLDIIKPNSQPITTSLSNTNNQDLLDLLGLGPISSTPTTDTGGNNMGLIMENNNSNVLISNQNSNFLSGDLFGDSNTSTERNVPTVTAYQKDGLKIIFSLEKIPDSNTLSINVATTNCTVSTMTDYIFQVAVPRSFQLQMFSPSGTVLAPNGQVTQDFRVTNPSKAALRIKVRLSYMIDGNPVQDETEVNSFPENIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2V8</accession>
    <name>A0A6P7G2V8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Zinc finger protein 260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC114335320</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141342.1">
        <property type="nucleotide sequence ID" value="XM_028285541.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141344.1">
        <property type="nucleotide sequence ID" value="XM_028285543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2V8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285541.2">
        <property type="protein sequence ID" value="XP_028141342.1"/>
        <property type="gene ID" value="LOC114335320"/>
    </dbReference>
    <dbReference type="GeneID" id="114335320"/>
    <dbReference type="KEGG" id="dvv:114335320"/>
    <dbReference type="CTD" id="41740"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001235">
        <property type="entry name" value="Si:ch211-119o8.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028141342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028141344.1"/>
        </source>
    </evidence>
    <sequence length="754" mass="87489" checksum="97E3467CF3818E43" modified="2020-12-02" version="1">MDQPPLSTTVVKSEVKSEYVEEDAELPQTNIIEIERTDEENGEVQTVVLQNIQIQDSGEDQLAFIGKIISQTNSNGNYQINSLDENSVIRTYIINNTQYQEVETDDIFYEGLEEDENSIEYVIEEAVEYQETDENIEYTQLTTLQEEYEFHDGVEEETIDDTDIQEVYGEEETEEEEQMEEGNDNEIMNINGVPLQVRNTTEGDYNIDENIKLECPMECDMCNKSFRTSAGLKRHITVNHEKRDEAESDDPLTLKLCPCCGEPYDTAHQAGDYKCNFCEKLFTQSNFLKRHLSIEHPKDDKYVCIECKCDLATKELLIDHLRFHPIKSVKCKECNKEFTRKYHLDRHIGQTGCMGQPRKVFECRVCKRCFTRRDNLAEHLRNHAGQSKKKKKFTCDYCNKEFQGVNLLNIHVRTHTGEKPYQCDLCPKSFPSTGAMKKHRRMHTGEKPYRCFECDRTFAAKETLNRHYRTHTGEKPHKCKFCGKSFIQPSQLRAHIFHHTGENAYTCQYCGRAFNRNLRLTTHIKFMHEGAEPLPCSKCDKTFFRKEDVARHMLSHSGERPFLCEVCNKGFAVKSSLKIHMNIHRKEQPCSCETCGRAFIRRDCLMRHIRARHRDVLEDILASAEKKRLQQQLLTAVSTSPMTITENIVWNELTLTESVKELLTLLVDEECLLEFGYPDAPVDRVLDSVIKRCGHTPASEEDFDYIGRIRENAKLLFTAVIDDDAVKELLNNQTVDEVILHVLRLAKKQQENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3I6</accession>
    <name>A0A6P7G3I6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tumor protein p53-inducible nuclear protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114335533</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Diabrotica</taxon>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
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        <subcellularLocation>
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            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="LOC126892370"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
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    </dbReference>
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        <property type="entry name" value="DOR"/>
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    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="218"/>
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517850.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
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    <sequence length="256" mass="29199" checksum="3821F38E9E9580BB" modified="2020-12-02" version="1">MNRETMFQNLANYLLGSVLSQEPGATAEGVEENRAVRLRAEDEDDWVLVDRDSEGNSDTSSVESLDDIDEEDNVIERVLTRTSSTSSLPCGSNMEESWFVTPPPCFTSEGPIHMETSPLENLLIEHPSMSVYHIHPSRRHFTVTVPVRPPSSASRLSDEEEDLEVEEENVEGEAVAVVNRVPRLNRLQVMQQQERQRHKSKRAQKVQMQKACQAIKRGNLERNNKAREVNSRNRRQRRGERSQGATRSYANNNRKC</sequence>
</entry>
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    <accession>A0A6P7G9B6</accession>
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    </dbReference>
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        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145796.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028145796.1"/>
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    </evidence>
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</entry>
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    <accession>A0A6P7G9U3</accession>
    <name>A0A6P7G9U3_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339434</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC114339434</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498477.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028145894.1"/>
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    </evidence>
    <sequence length="98" mass="11289" checksum="4C3438DEE8A747AF" modified="2020-12-02" version="1">MRQVRTILVVTVIMIIIITGIEAKKKKSKKYSKEMILRQKETNAVNFIRLAVMRIIYGIATRIGFGEQISDAMNGAFVPPGTDYEYDDFDDDDYDIDY</sequence>
</entry>
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    <accession>A0A6P7GA12</accession>
    <name>A0A6P7GA12_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
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            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </alternativeName>
    </protein>
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        <name evidence="9" type="primary">LOC114335271</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
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            <taxon>Diabroticites</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
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        <property type="interactions" value="808"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:translation"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
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        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028141290.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17184" checksum="630137D24A1C356A" modified="2020-12-02" version="1">MQAPTTKPKRDPIHSVQVFGRKKSATAVAYCKRGRGVLRVNGRPLSQVEPKMLQDKLQEPILLLGKDKFSAVDIRVRVNGGGHVSQIYAIRQAISKALVAYYQKYVDEASKKELKDILIQYDRTLLVADPRRCEPKKFGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD10</accession>
    <name>A0A6P7GD10_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Exosome RNA helicase MTR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114338086</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144472.1">
        <property type="nucleotide sequence ID" value="XM_028288671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GD10"/>
    <dbReference type="FunCoup" id="A0A6P7GD10">
        <property type="interactions" value="2465"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648365.1">
        <property type="protein sequence ID" value="XP_050504322.1"/>
        <property type="gene ID" value="LOC126883121"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GD10"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="116"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="345"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="969"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028144472.1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116254" checksum="545AE5AD78B51556" modified="2020-12-02" version="1">MADLIDDLFDCFEDETPSKETIKTSDTFKRKSDQHDDEEEESTPAPKRVKNDEIVIDINFEELKNRIVVHTIDTVDSCTHEVACPPGHDYIPLQPARGEPVKQYPFKLDPFQKESILCVENNQSVLVSAHTSAGKTVIAEYAIATSLKNKQRVIYTTPIKALSNQKYREFFDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVIFDEIHYMRDKERGVVWEETLILLPHNVHFVFLSATIPNARQFIEWVSHLHQQPCHVVYTDYRPTPLQHFIYPAGGNGIHMVVDETGTFKDDSYNAAMAVLQNSGDAAKGDQKGKKGGFANKDPTQTDIFKVVKMIMERNFAPVIVFSFSKKDCELYAMQMTKLDFNTTAEKQLVDEVFNNAMDVLSDDDKQLPQVENLLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTGMRKFDGSEYRWITSGEYIQMSGRAGRRGLDDKGIVILMVDEKVPPAAGRNIVKGLPDPINSAFHLTYNMVLNLLRVEEINPEYMLERSFFQFQNQAAIPGYYDDYNEKLELFNSLEIKDEERIQSYHVIRTELDLLGVKFRTYLTSSQYLLPFLQPGRLLKIKSTEDEYDWGAVVNFKKVQEIIPGRKNKQGQSKTQTKVKVDILLHVLPENSDETMIPKPCLEDQKGEIEVVTVDSTLITHLSSVRLFCPNDLRSKDSRKGMYKAIKEVKKRFPEGPPLLNPVTDMKIKEEEFLSIVEKIEILEQKMYSHPLHKTEILSTEYPKFEKKIIVQTELESARSKLMEAKSVLQLDELKSRKRVLRRLEYCSSTDVIQLKGRVACELSSADELLITELIFNGVFNPLTPAQSCSLLSCFVCDEKSQETPKLSEELSGPLRVMQDLARRIAKVSNESKLPLDEDAYVERYKPFLMDVCYNWCTGSSFKTICEQTDIFEGSIVRCMRRLEELLRQMVQASKTIGNSELEDKFNAAIKLIKRDIVFSSSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF61</accession>
    <name>A0A6P7GF61_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Uncharacterized protein LOC114341642</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114341642</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Lamellipodium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028148254.1">
        <property type="nucleotide sequence ID" value="XM_028292453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028148260.1">
        <property type="nucleotide sequence ID" value="XM_028292459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF61"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292453.2">
        <property type="protein sequence ID" value="XP_028148254.1"/>
        <property type="gene ID" value="LOC114341642"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292459.2">
        <property type="protein sequence ID" value="XP_028148260.1"/>
        <property type="gene ID" value="LOC114341642"/>
    </dbReference>
    <dbReference type="GeneID" id="114341642"/>
    <dbReference type="KEGG" id="dvv:114341642"/>
    <dbReference type="CTD" id="35306"/>
    <dbReference type="OrthoDB" id="6019202at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01225">
        <property type="entry name" value="PH_Cool_Pix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11877">
        <property type="entry name" value="SH3_PIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
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            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022658"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJX4</accession>
    <name>A0A6P7GJX4_DIAVI</name>
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        <submittedName>
            <fullName evidence="10">PR domain zinc finger protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114343571</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
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            <begin position="1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028150216.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="42228" checksum="03AF62AF1B7A2FA0" modified="2020-12-02" version="1">MAPRKKRNNRKKKSLDENKNENVTISKNLSQKYNTEKLNVICDEIKVTEDVKKVNINKTDKNFVEDSNAVQKSVLYSCQLCYKIFSLEREYINHKEKCSNSNFHIISNVRINGTSETVTETIPVQDDSTNVSPNGNSLYPCRNCSIVFPSENTCKSHMNQCKKNNLRDKELINIRTKESDNPRCQSPYTGSEKLSDVSRTTEISEEPMPKQPKYDISIYDYDEIDSEDDTPKVPSDTKCKYCEFIADNPMELLKHKRELHTAAKQTLPVHEIQKYFDYPDRSFCPICEQPVKTKNFRSIFIRHLLVHAPSMSFQCRICKKRFRRLDHMKAHEKRHVLTYAELQALQENVNNDKPTEDILIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPB1</accession>
    <name>A0A6P7GPB1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114339183</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028289809.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050655878.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050655879.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511837.1">
        <property type="nucleotide sequence ID" value="XM_050655880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPB1"/>
    <dbReference type="FunCoup" id="A0A6P7GPB1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655878.1">
        <property type="protein sequence ID" value="XP_050511835.1"/>
        <property type="gene ID" value="LOC114339183"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655879.1">
        <property type="protein sequence ID" value="XP_050511836.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655880.1">
        <property type="protein sequence ID" value="XP_050511837.1"/>
        <property type="gene ID" value="LOC114339183"/>
    </dbReference>
    <dbReference type="GeneID" id="114339183"/>
    <dbReference type="InParanoid" id="A0A6P7GPB1"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000628">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048855">
        <property type="entry name" value="P2R3A_B_D_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21161">
        <property type="entry name" value="P2R3B_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="873"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028145610.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="103295" checksum="D4B7F892F124B430" modified="2020-12-02" version="1">MATTARRRDPDDDIAAIAKQISDQAEAIYQNWKSRGLGPADLLTCHAAGDTTKLGSMLKPQPPSKPASLDILAQAPTMDNNRLEKLVKNFVDEDKARIAAARNKSQSPVTSPVNKMPSSIQYALQKFEKGSSQTDSANGVGVRDGGSGAGSYLRKTATLPNRKVGVGSGGLSGLSGGGNSDSGVGVNSYNSSSTTNFVQHQQPVKPAIGQKPQISPKPRLSDTIEMTLPPDVVTGAGLQTWPLKNRVIGTDNVKKSAGTTGENHIGTGYLSTKKTSAGGENHVVGGYQGIKKLNGDGENHIGSGYHKSQPSSVTIDQVALEEKRLINALKNGEVVSDEPVRTIGKLSRDITPIKQPPTTKEPPPPEKLIDPAVPTTTPINSSKWGLRSTPRRPEQQVPHPELTTSQRQHLRQSAASNPVRPFLTRGSVAERVLIFERCPSDLLLDKRVRAPVPQITKTQPLPKQPPLQHTTLQRHVRAHRNVNIPRFHFPSGKPVPPGHLDIIKTKVTAAFAKIGERASREHFGALTQATQLPLYWKTPLYLAACADKGSCTLEQFMTFFQSMSSHCHDGASRFIYILTRGRRSWLAPEDFIPLVQDVVETHPGLTFLKEATEFHSRYVHTVIARIYYCVNRSWSGKITTSELRRSNLLNIIQLLEDEEDINQITQFFSYEHFYVIYCKFWELDRDHDLFIDKHDLTRHNDHALSTRIIDRIFSGCVTRGHKKHQDERMSYTDFVWFLLSEEDKLHPTAIEYWFRCMDLDGDGYLSMYELEYFYDEQMHRMESIGIETLPFQDCLCQMLDMVKPKIPGKIALSDLKKCRMTSIFYDTFFNLEKYLDHEQRDPFASQRDHDIDGQEMSDWDRYAAEEYELLVAEEGGNDQPDSFSFDEGNEDDLLSHHLDGALDDDDDDEDEPAELSEDSDCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQS9</accession>
    <name>A0A6P7GQS9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sensory neuron membrane protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114341002</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147588.1">
        <property type="nucleotide sequence ID" value="XM_028291787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQS9"/>
    <dbReference type="FunCoup" id="A0A6P7GQS9">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651552.1">
        <property type="protein sequence ID" value="XP_050507509.1"/>
        <property type="gene ID" value="LOC126885120"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQS9"/>
    <dbReference type="OrthoDB" id="10024078at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF69">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028147588.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59961" checksum="FF81D20A7A281D11" modified="2020-12-02" version="1">MELSMKLIIGGAVMVVGTILVGFVSFQTLVNFVVKDQTALRKRNEIRGIYLKIPFPLNFKIYFFNVTNPMEVHNGATPILQQVGPYYYDEYKEKINVVDNDAEDSLQYDAFDTYQFNKTLSGSLSDEDYVTIIHPLLVGMVNTVTATSPALLSIVNQAITHIFNEPKTIYLTDKVKNIMFNGMELNCQGSDFASKAVCTQIKSQMKGVKESPTQKNVLLFSLIGPRNATIADTIKIMRGIKNYRDLGRVLEVNGKKDIGLWGTEECNRFKGTDGWIIPPLLKPEEGIKCYTTHLCRNIALDYVRDDVVKGINVRRYEGNLGDQQNNPADKCYCPESRPCLKTGTFELSKCVGAPIIASLPHFLDADESLLTQVKGLSPVHEDHIMNVNIDPMTSAPISVRIRVQMNLEIAPNPKITIMNNLTTALHPIFWLEDGLDLEGPLFTKISNIFILLKMAHIMKWLFLVASIGVFGYGSYTHFKSSKKVKITPVHQRTTTDDNPVKRSTNELISQLRNEGKNGYTNNIMSGHEFDRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVI2</accession>
    <name>A0A6P7GVI2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drosomycin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114347225</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153756.1">
        <property type="nucleotide sequence ID" value="XM_028297955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVI2"/>
    <dbReference type="FunCoup" id="A0A6P7GVI2">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297955.2">
        <property type="protein sequence ID" value="XP_028153756.1"/>
        <property type="gene ID" value="LOC114347225"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649922.1">
        <property type="protein sequence ID" value="XP_050505879.1"/>
        <property type="gene ID" value="LOC126884114"/>
    </dbReference>
    <dbReference type="GeneID" id="114347225"/>
    <dbReference type="KEGG" id="dvv:114347225"/>
    <dbReference type="InParanoid" id="A0A6P7GVI2"/>
    <dbReference type="OrthoDB" id="7800919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.10:FF:000001">
        <property type="entry name" value="Drosomycin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00304">
        <property type="entry name" value="Gamma-thionin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00505">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027784971" evidence="4">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028153756.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7219" checksum="56D001C9B6D6569A" modified="2020-12-02" version="1">MKVLFIFAFIVILATSAKTVFGDCLSGRFGGPCAVWDNETCRRVCQEEGRPSGHCSPSLKCWCEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H679</accession>
    <name>A0A6P7H679_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114344833</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028151470.1">
        <property type="nucleotide sequence ID" value="XM_028295669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H679"/>
    <dbReference type="EnsemblMetazoa" id="XM_028295669.2">
        <property type="protein sequence ID" value="XP_028151470.1"/>
        <property type="gene ID" value="LOC114344833"/>
    </dbReference>
    <dbReference type="GeneID" id="114344833"/>
    <dbReference type="KEGG" id="dvv:114344833"/>
    <dbReference type="InParanoid" id="A0A6P7H679"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="307"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028151470.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40497" checksum="BC952CC6FF6C5727" modified="2020-12-02" version="1">MSNSVVSNLVCVNDYKEHAKKKLPKMYFEFYYSGAGQQKTLKWNKIDFNKYRIRPKYMRKVSNRNLSTTILGKPVAFPIGISPSAHHKIAHVDGECATAKAAQDLKTIFILSSHSNSTFEEVSKAAPQGRKWLQLYIFQSREITKDFVKEAENNGFEALVLTVDFTLFGIRLVNLRNQFRKPPNVTSILLDKYRENKTISNFVDFSDPEADWSYITWLKTISKLPIVVKGVLTAEDAIAATDAGASAILVSNHGARQLDSLPSTIEALPEVAKAVGHRIEVYMDGGIRDGTDVYKALGLGARMVFIGRPALWGLTHDGEKGVKKILEILKTELDNAMGITGCSKLTDINQHRVVHENYYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H7X4</accession>
    <name>A0A6P7H7X4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114347276</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028153798.1">
        <property type="nucleotide sequence ID" value="XM_028297997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H7X4"/>
    <dbReference type="FunCoup" id="A0A6P7H7X4">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659949.1">
        <property type="protein sequence ID" value="XP_050515906.1"/>
        <property type="gene ID" value="LOC126890767"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H7X4"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07529">
        <property type="entry name" value="HAD_AtGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045228">
        <property type="entry name" value="Gpp1/Gpp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028153798.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25843" checksum="96044DD5E8B78577" modified="2020-12-02" version="1">MSASKAFKRVTHVIFDMDGVLLDTEILYTQATQKILDQYGKTFTWEVKSQMMGLHGQEMAERIVKTYDLPISAQEYYKQAMEQYYIIMPECQLMPGAITLVKHLHSKNIPIAVATSSSQESFNLKTGKHKDFFSLFNHIVCGGSDPEVKSGKPAPDIFLVCASRFTDKPSPEKCLVFEDAPNGVLAAISAGMQAVMLPDENVSPELRKNAHVVIDRLDRAPLEKFGLPSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICW6</accession>
    <name>A0ABM5ICW6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130062.2">
        <property type="nucleotide sequence ID" value="XM_028274261.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274261.2">
        <property type="protein sequence ID" value="XP_028130062.2"/>
        <property type="gene ID" value="LOC114326065"/>
    </dbReference>
    <dbReference type="GeneID" id="114326065"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046096946" evidence="3">
        <location>
            <begin position="20"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130062.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="298" mass="33395" checksum="8700AAA97979509F" modified="2025-10-08" version="1">MTLTIKLVAIFAFAAAATGSPLTTFGKRTPALPTPSKEPDSYQPFQTQLPMELELPKEEANPVPFYAPEPSTDLKAPQESQEPDYYQVPIPNQELAAPIDTEWNPNNDPIYYYEVPAIINNQESPTREFPKKYNEDIHDKKKPFASQPKVEIIFEPISKQQYEEKQIELTKKPTAGLPKYLDTVTTSSDQVESASGTFDHGLSSQLTASLGIPSSAPTHEGASQGERLEFHMVGHDGPLSYKWGYDTGKGHNRLFRFEERDKEGVVKGHYGFYDKEGKLQVVHYDAHPHTGFHVAENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE51</accession>
    <name>A0ABM5IE51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130824.2">
        <property type="nucleotide sequence ID" value="XM_028275023.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275023.2">
        <property type="protein sequence ID" value="XP_028130824.2"/>
        <property type="gene ID" value="LOC114326606"/>
    </dbReference>
    <dbReference type="GeneID" id="114326606"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="249"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130824.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="443" mass="50570" checksum="04723BA648624E64" modified="2025-10-08" version="1">MDRYVLETYLYTSDCGEDGYLFNSSSSSSDSEDDEVECTCDAETEPPPDKKQKLTESGETEAAVELKPKNKTMLYGLLEVDVKTEPEPKKKQKAYEFVELDVPTPTDRKQDGFVEIEVPILNEYDFKNSFRVNKTTYAKVLEMLYPSFSADHKGGRERITAEKATYIFLWYLGNKETFKQMADRFKNTTSTLHGIVKTATSALSQKLSAQIIWPSDAEYSNISKLFQQVGNLKGCLGVLGVSYIRIKSNIKNNEIYENEHYYQSVILQGVVTVNGKFLDIFIGGGSNKPEQLLQKSQLFIEAENNLLGDYYLLSSKDYSNRKWLVKPYKDNGHLTVEQTIFNTCHQTIVNTFTESIGFLKGRFQRLQNVENRAMGMAVQCVESACMIHNLAIDCEDEHEDFCFLDFPDVEAREDVLPQDDINGERRDKALEDLINNSSEYKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGY4</accession>
    <name>A0ABM5IGY4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028132509.2">
        <property type="nucleotide sequence ID" value="XM_028276708.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276708.2">
        <property type="protein sequence ID" value="XP_028132509.2"/>
        <property type="gene ID" value="LOC114327976"/>
    </dbReference>
    <dbReference type="GeneID" id="114327976"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="58"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="456"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132509.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="55352" checksum="66F0DDE9B46C1006" modified="2025-10-08" version="1">MNILRRLLPNINPAALSLCNAINITKQNILNGSQIRYASNEKKDQKKGDHRIEKDSFGELKVPADKYYGAQTLRSVMNFPIGGEFERMPYPVISAMGVLKKAAALVNKDYGLDPKIADTIACACDEVISGKLYCDHFPLVIWQTGSGTQTNMNSNEVISNRAIEILGGKLGSKTPVHPNDHVNKGQSSNDTFPTAMHIAVALEIEHTLMPGLKMLHDALACKSKEFKDIIKIGRTHTQDAVPLTLGQEFSGYAQQICFGIDRVCDTLPRLRMLALGGTAVGTGLNTNKGFAEKSAAKISELTGLPFTTAPNKFEALAARDAMVEVSGALNVVAVSINKIANDIRFLGSGPRCGLGELLLPENEPGSSIMPGKINPTQCEAITMVAAQVMGNHVAVTIGGANGHFELNVFKPLIVSNVLRSIRLLGDSCTCFTKNCVNGIVANKERINKLLHESLMLVTALNPHIGYDKAAQIAKTAHKENSTLKKTAVKMNILTEQQFDEWVKPEKMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHF2</accession>
    <name>A0ABM5IHF2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028132831.2">
        <property type="nucleotide sequence ID" value="XM_028277030.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277030.2">
        <property type="protein sequence ID" value="XP_028132831.2"/>
        <property type="gene ID" value="LOC114328239"/>
    </dbReference>
    <dbReference type="GeneID" id="114328239"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132831.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IP73</accession>
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        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomelidae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137884.2">
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN 154-LIKE"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="404" mass="47299" checksum="43756FBCC2F29EB7" modified="2025-10-08" version="1">MELSQVSEKSCKIETSNHEVDDALLDTMKIEIKEEPFSESAQEEFVYSDLKELPVKTEIEQDEQKFALFEESQVDEKCFLQEENQMQIMEPLTKPLYHKGNYVSRCSEGKRLSKNKKVQTGQECYNCEICFKQFSQEVLLKRHLRVHTGEKPHKCEICFKQFSQAGHLKGHLRVHTGEKPHKCEICFQQFNRTHHLTTHLRRHTGEKPHKCEICFKQFSVADHLKTHLRVHTGEKSYKCEICLKQFSQAGSLKIHLRVHTGEKPHKCEICLRQFSQAGHLKVHLRVHTGEKPHKCEICFKHFIQAGDLKKHLRVHTGEKPHKCEICFQQFSRAHHLKTHLRVHTGEKGYECEICFKQFSAAGNLKTHLRVHTGERPYNCEICFKQFTHKNSLQQHTKVHAGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQ04</accession>
    <name>A0ABM5IQ04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-associated protein 1</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138522.2">
        <property type="nucleotide sequence ID" value="XM_028282721.2"/>
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        <property type="nucleotide sequence ID" value="XM_028282722.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138524.2">
        <property type="nucleotide sequence ID" value="XM_028282723.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282721.2">
        <property type="protein sequence ID" value="XP_028138522.2"/>
        <property type="gene ID" value="LOC114332931"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282722.2">
        <property type="protein sequence ID" value="XP_028138523.2"/>
        <property type="gene ID" value="LOC114332931"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282723.2">
        <property type="protein sequence ID" value="XP_028138524.2"/>
        <property type="gene ID" value="LOC114332931"/>
    </dbReference>
    <dbReference type="GeneID" id="114332931"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
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        <property type="entry name" value="FATC_dom"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
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        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
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        <property type="entry name" value="Tra1_central"/>
    </dbReference>
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        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
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        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF20206">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="5">
        <location>
            <begin position="2640"/>
            <end position="3198"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="3466"/>
            <end position="3784"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="6">
        <location>
            <begin position="3788"/>
            <end position="3820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1998"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3214"/>
            <end position="3253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1448"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3216"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3243"/>
            <end position="3253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138522.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3820" mass="438488" checksum="5CAF3E4FCD07C6C6" modified="2025-10-08" version="1">MQASTSSSSSSSMGSVHPHTALMNQFKSYVTMLADPECKDVLKLKATQELSKHFEIILNSALYSNFLDHSMNIFLKILDEGYPLFVAEYNIQQVRKLILEMLYRLPTNENLRPYVKQILSLMFRLLEIDNEENVLVCLKIIIELHKQYKPPFSPEIQKFLQFVKSIYSNLPNHMNKIFEPKPPIKVKDLSEVNIEELLKETFTMTVIQTEARNEDGTLIAYYLIPKAVLSLKVLQELPIIVVLMYQLYKQSVHQDVSDFIPLIMNTITLQPTLKQRQAESFNKEIFVDFMGAQIKTLSFLAYIIKIYQEVVQNHSAMMVQGMLGLLTLCPMEVAHLRRELLIAARHILATELRNRFVPHMERLFDEDVLLGRGWTTHESLRPLAYSTLADLVHHVRQQLPLADLKRAVHLFSKNVHDDSLATTIQTMSCKLLLNLVDCIRLRSEAENSHEGRELLMRMLEVFVLKFKTIAKIQLPILTNKCDQRKQEVQSTPPNQTPSQTGSDKTETETKPNPADALEAVLVNAQVAQPKEEKSKFGFPQNNNCNVADYRSLVKTLVCGVKTITWGCSACKSGADQATVQSKHFAPHETLVFVRLVKWALQALDIYTLNVGPQPAGLPQRMNQQNVRSKEEKEVLEHFSGVFSMMNSQTFHEIFSTTIEYLVKRVYKNPTLQTVPNTLLANPTTSPIFATVLVEYLLERMEEMGSNLERSNLYLRLFKLVFGSVSLFPQENENMLRPHLHQIVNRSMELAMSAMEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLEGLNRLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSHVLISQGLRTLELCVDNLQHDFLYEHIQPVRAELMQALWRTLRNNDQVAQVAFKVLGKFGGGNRKMMIEPQRLDYVSTDFDPPAILARFHDHYQEIEFPVSKVIETAFNALKQSSTDPFYRKQAWEVINCYLTASRCLDDDENTLINLFLHPGFQDPNTIPNIKGSTYKSIYKEARETHQTALTGMFVAAAIKELRETVIPALVSLVRHYTMVAVAQQSGAFAYSPEPNKQVTLDPLVLVDALAIIMGHEERELCKPGHLGLVLIVDTASTLLGSKEMACRLPLIEYLSEKMCALCYERAWYAKLGGCIAIKFMFERCALKWIYEHMFMFLKALLFVMMDLTGEVSSGALDCAKENLQKMLIVCVTPPPEGSDQATRNLQQEALNKVTHELVRQVTSPHTMVRNQSMASLRLLAKKQNKTVTAVMEPFKDVLADMVPPKKHLLKHQPAIAQMALMDGNTFCTTLSPRLFTINMSIEEHSLFIQDLISLCNTEDNKLNTFSCYKSITNFVPLRTSALRVLAACYYLDEVREDIFQVLYKSLEKPNTELQETAFECMKQFKAGYPIDSKLVYTTVRPLLLTLGDVKTLTLNGVKMLSYLTQLFPHVFKEKLCEQLLAFLNELMKNLKENYKNNQGNGLSKKGDDEQKIVTIISVFHQTPAASSKFINQLCQLILETEQAMEVEASSPFREVLMKFLLRFPGETLTMFLSDKYIKDKQFSRYLEYLIKHKEGKPFRDFIQSNMTKRLITMVLSNYVNLLLEQNERNELQYQSIRIVSLLIKFDDQWLSTQQELVDALKQIWCDDSYQERHKNIEHLEYTHWKEPKLVVKILLHYFCHHPTDIDLLFQLLRATVDRFLPDFQFLRDFLENTVAQNYTVEWKRSAFFRFVELFPSNEMSQELKAKVLQLILIPCFAVSFERGETNKLVGGLPMPYQDSTDNVVSVFINKLIDSDNPFPSADCVRISLLQFSCLLVEQASPHIHDHDPSNNAQGFKLRRLMTFAWPCLLVENCIDPATRYHGHLLLSHIIEKFAIHRKIVLQVFHSLLKAHAIEARSVVRQALEILTPSMPLRMEEGNTMLTHWTKKIIVDEGHSMQQLFHILQLVVKHYKVYYPVRHHLVQHMVSSIQRLGFSPTATLEHRKLAVELAEVIIKWEIYGIKEESESTETTENPPVKRPSIEESAESSRKKLAVAGPSNAPQPAVKAEPSVNKPIDRTHTDNVLNFLLRLACQVNEPAPTNPMNPVANSPGEVLSRRCVILLKTALRPDIWPQPVDLKLAFFDKILTSIEAPNHNVANICTALELLTYILTVFEKEQILASFKPLQRGIGACITSNNSRIIKLVHNLLTKLFTLFPMERTNTNLSCKYEELDILYATVGKVIFEGLSSYEKKENPSSLFGTVMILKAACANNHSYIDLLITPFMRVLNKLSREHLNHSSENTALTSELLILSLDLVKTRVVVMGVEMRKTFIGSILVGLIERTQDIKVMKFITRMLEEWMKCKNVVTLNQAPSLREKSILLVKMMQYVEKRFQDDNELNAQFLELVNYVYTDKQLKATELTSKLEPAFLAGLRCTQPHIRAKFFKVFDEAMPRRLHDRLLYIICSQNWDAIGPHYWIKQCIELLLVTAAPGDGIRMSHESSILPAITSVIPEKQKREEFSRHQLQNPDFYTSEIKEEVLDVDLSNIDSNPLVEEKPVIREETIKMLKKDYESTEIARNITTDRFLLATSQLCHMDTSLAEHVWLSLFPKLWAILEPEQRTTLEKDIIPFITSGTHIIQKDCHPSAINTFVEALYRCTNHIQMAPFLMTYLGKSHNLWHRMALGLEQMAYEMSVPKSSNPASCYEFEGEPLKTELLDCLGELYHLLCEEDCWAGLWQRHAHYKETSIAIAYEQHGFFEQAQAAYEAAMAKHKADNSMGPVPMHTQRETLLWNDHWIRCAKELNQWDTLMEYAKNGCYDPYLLLESAWRIPNWELMKEASANVEYSCPKELGWKITMYGGFLVICQPDDSKPLKYVERYVESASALCLNEWRRLPHIVSHIHLPYLQAAQQIMELQEAYQIHKGLLQSHHNSLHDMKAIVKTWRNRLPVIADDLVHWNDIFTWRQHHYQVIVNHYDNQRDASTTHSASAQSSIHFGKIARKHKLVNVCLESLNKIYSISSVRIVDCFQKVRQQVKCYLQNSSVNKNDINEGLEVLSRTKMQYFSKEMTAEFYALNGLLFQLSNKSDEANKMFSAAVQMHDASTKAWALYGDYLEQIFTRDQRQINLGVNAMTCLLHACRHQNEAKARKYLAKVLWLLSYDDENSSLMEALDKYSVGVPPLLWLPWTPQLLNCLVQYEGNVILNLLCQVGRMFPQAVYFPIRTLYLTLRTSVARKTNSVQRLTLQQHQSHESQNSEAGAQSNSQGSLSNSSEGATTVPTEGSSIKATPAMIRCSKIMKMQRDIHTTVLSSLEGIADQMEWFRENWYEEVLRQLRQGLTKCYAIAFENREGVNEAKITPHILNFVKKLMSTFGIGVENIISSSVNVTFNSAASESLARRAEATYQDPVFKAMKSEFTKDFDFSQSNSMRLHTLIFKLKKWIKILDDRSKMFLQSSLIEEKCRFLSNFTLKTAEVELPGEFLLPKHNHYFVRITRFMPRVDVVQKHNAAARRLYIRGHNGKIYPYLVVNDSGLADARREERVLQLLRMLNLYLGKQKETARRFLHYTVPRVIAVSQQIRLVEDNPASVSLLDIFKKSCTKLGIEHDEPIQYYYERLAQVQSRGIKASHQVYRDILKGIQQSKIPRNIIKHWAIQTFPSATDYWQFRKMFTLQLALACFAEYVFHLTRLNPDMMYLHQDSGLMNVAYFKFDVDDSTGELDTTRPVPFRLTPNIIEYLSTIGVTGPLTTTMIATSRCFIYPNFKVLSILKPIIRDEMMLARAKKAEDLNNPEKMNDASEQIINMVNKAVTSISNRLTNLAQFEGTDSKVATLVAAANSPDNLCRMDPAWHPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWM8</accession>
    <name>A0ABM5IWM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_028145582.2">
        <property type="nucleotide sequence ID" value="XM_028289781.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289781.2">
        <property type="protein sequence ID" value="XP_028145582.2"/>
        <property type="gene ID" value="LOC114339147"/>
    </dbReference>
    <dbReference type="GeneID" id="114339147"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="76"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145582.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="386" mass="42453" checksum="7BF3DCBE51399DC3" modified="2025-10-08" version="1">MRFTSARKLKSLITVALGGYISFSALTYYKNRNAFYRDMVMPLVHLLDPERAHNLAVFVSQYRLLPKSNYDDPSSLNVAIFQKEFTNPIGIAAGFDKDAKAVLGLKDIGFGFVEIGSVTPNPQPGNEKPRVFRLPEDSAVINRYGFNSEGHDTVLQRIQRIRSSKENVIIGVNLGKNKTSDDAVGDYVKGIEKFGPFCDYLVINISSPNTPGLRSMQNKDVLKALLSSTIAARNNLKMDSKPPLLLKLAPDLNTEEKKDIAEVLKQTACRVDGLIISNTTIDRPDYLLSTNKKETGGLSGKPLKEKSTEMIKEMKRLTNLPIIGVGGICTGADAYEKIKAGANLVQIYTSMVYEGPEIVSQIKKDLDKLITADGFNNITEAVGKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWX0</accession>
    <name>A0ABM5IWX0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Unconventional myosin IC</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146050.2">
        <property type="nucleotide sequence ID" value="XM_028290249.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146051.2">
        <property type="nucleotide sequence ID" value="XM_028290250.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514271.1">
        <property type="nucleotide sequence ID" value="XM_050658314.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514272.1">
        <property type="nucleotide sequence ID" value="XM_050658315.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290249.2">
        <property type="protein sequence ID" value="XP_028146050.2"/>
        <property type="gene ID" value="LOC114339592"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290250.2">
        <property type="protein sequence ID" value="XP_028146051.2"/>
        <property type="gene ID" value="LOC114339592"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658314.1">
        <property type="protein sequence ID" value="XP_050514271.1"/>
        <property type="gene ID" value="LOC114339592"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658315.1">
        <property type="protein sequence ID" value="XP_050514272.1"/>
        <property type="gene ID" value="LOC114339592"/>
    </dbReference>
    <dbReference type="GeneID" id="114339592"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF679">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="12"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="9">
        <location>
            <begin position="843"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146051.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1022" mass="119139" checksum="66FDC022AFD858D4" modified="2025-10-08" version="1">MEHHLYDRDRVGVQDAVLLEDYTNQDVFVDNLQKRFKEDVIYTYIGPVLISVNPYRELNIYDSKTVQEYRNKHFFEVPPHVFAITNNAYTSLKEENREQCILISGESGSGKTEASKKVLNFIAAVTDQKGEVEKVKDKLLFSNPILEAFGNAKTNRNDNSSRFGKYMDIQFNFEGNPVGGNILNYLLEKSRVINQAPGERNFHIFYQLLAGASEEELDKLHLKRSLSSYYYLSNGHNGTTTINDQKDFSEVKRALTTLEFTEKEQSDMFSVISAILQLGNIGFSEEEGRTLILKPEQVDIVSKLLDCDKEKMSLALQQRTIETIRDVVTSPLNRELSIYARDALAKAIYDRMFTWLVKRINDSLQPSDKRRNVVMGILDIYGFEIFERNGFEQLCINFCNEKLQQLFIDLTLKSEQDEYEKEGIVWQHIEYFDNKIICELIEEKHKGLIAYMDEECLRPGDPSDKTLLAKLDERLSYHPHYISHKKADIKLQKIMGRDEFRLIHYAGNVTYNVKSFIDKNNDLLFRDLREAMLSSKNSIIQSVFFEHEQKSKKRPETAITQFKTSVNNLMNILKDKEPSYIRCIKPNDSKQSGIFDFKLVSHQVTYLGLMENLRVRRAGFAYRRDYERFLKRYKCLSKETWPNYKGHAKDGVQALVNSLGYDQEEYQMGKTKIFIRHPKTLFQTEDAFQVKKHEIASIIQAHWKGYLQRTRYRKMRESAIIMQKYIRRLLAKRLAEKRKKAAFAIRRFIKGFITRNGPPTDENKSFLSMAKVQWLKRLAKTLPKQILYRRWPPCPFVCREASKHLEKMHGAHLSRVYRLALTPEMKRQFELKVLAESLFKDKKKSYKDSVPHLFEPDRVQEINIPMKELYASQLNGDKEIYSTNVIKFDRHGYKPRERLMVIGSKNLHLLECKGSLKPKHCLPLNRLTFTITPENDKMLLVQIPEDLIKKDKGDLILEVPNLIEALTYVMDTLKDKSVLKIISQSHIEHNMKGKHGTIDIQHGDAPKIHKDKSGHLLIVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IY05</accession>
    <name>A0ABM5IY05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028148362.2">
        <property type="nucleotide sequence ID" value="XM_028292561.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292561.2">
        <property type="protein sequence ID" value="XP_028148362.2"/>
        <property type="gene ID" value="LOC114341748"/>
    </dbReference>
    <dbReference type="GeneID" id="114341748"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04443">
        <property type="entry name" value="DEP_GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037368">
        <property type="entry name" value="GPR155_DEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="808"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148362.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="873" mass="97319" checksum="E9B954805ECA08E0" modified="2025-10-08" version="1">MDEVYDAGTSFENLYPALTQCFAIIICGYVAGRMNWISETEAKGINTFIGTFSLPSLIFMSLAEVELSQVNWIFLLSILIAKSIVFFSVIIVTLLVGRPLKLGRAGIFAIFCTQSNDFAIGYPIVAALYKQTHPEYATYLYLMAPISLAILNPISFILMEIGKRRRDEGSEQILINDGEISNNLNSHRERLKLAVSVFKSIFMNPIIFMTILGILGNVVFKHNVPVYLGGTLKVLGSAFSASALFLLGLRMVGKVHKLKGATLVVPGILIMVKLLMLPIITREIISLLHVGQNATETVDLSTYGFLYGTFPSAPTVFVFANQYSIDVDLIASAMVVCTFVSAPLMFVSAKMITITNCDPSEYIKQLDSFTLDISILSLIASFWVLMVLILTKKILKIPHKITAALVISQLIGCLGAILWNTLHQKEGMAGYIQFSLFSVGVYSTRLWTMILAITLLFLQCRSLCYVLKLQPVFLLIGWGLPILLAALLLVFDKASTTPFEKRNPNFVYGASQAIIAVSLLVLCFIVTVGCLILHQRYRRRFTRYMDLSHDIASDQEQSQSTPEAETTADTAALSPNPSTSSDSGVGSVKAQKCCGLPTIAEGCCESQESPVVDIEDLLGDFDKKSNSTEIKGYLSVLSEEGMSPNADGLCPTRYGCAGPTREMCQGVVRQYQQQIDDDLELIEEEPESHEPQILRHTVLLILLLCSMFVGLALSIWTLVMEQMSGIYIELSFLDATLNFGQSIIVFAIFGLNTKEIMLPLLKYWRKIWYGANTLNLPAWHELSSETKHICDQFVTHHLQNCRSAIATDKRWRIKIYKNVFSGETFVEWLIEVGLARDRVEAVNYARHLVEGKVLRHINGVYHFYDRNLLYTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYF1</accession>
    <name>A0ABM5IYF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Natterin-4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149358.2">
        <property type="nucleotide sequence ID" value="XM_028293557.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293557.2">
        <property type="protein sequence ID" value="XP_028149358.2"/>
        <property type="gene ID" value="LOC114342765"/>
    </dbReference>
    <dbReference type="GeneID" id="114342765"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF10">
        <property type="entry name" value="IP19903P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149358.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26947" checksum="FFAD3267427E6264" modified="2025-10-08" version="1">MAGYGFKQEYPTHNCEQCQRNVTNYPSQPATCPHHSHNRPPSGYPSYPAPPAYNPYYNGNSAPMYPQPPTYPQPPTYPQPPTNSNWPPTHHGPSHSSYAIWVDCYLHSPMPNSAVRGGTDIDGQPIYVGRAFHEGDWLPAKVIPGRRCCYVSYDGKEYAKTNFQVLSHTSAHWVPGFGGQVPHNAIEGGRTVNGEKLYIGRVMHQHSQTVGKIHPSHRNCYIPFDGREIAYAAYDVLVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZG3</accession>
    <name>A0ABM5IZG3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152285.2">
        <property type="nucleotide sequence ID" value="XM_028296484.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296484.2">
        <property type="protein sequence ID" value="XP_028152285.2"/>
        <property type="gene ID" value="LOC114345692"/>
    </dbReference>
    <dbReference type="GeneID" id="114345692"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046294255" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152285.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="123" mass="13789" checksum="CB76CAE76484CDCD" modified="2025-10-08" version="1">MNFSSWIFFCLTFVICISTTLQAYIGEAPQCYGSQCPAGTTRCKKHMKSQQNGYLHITINCLDAYGGSLKEFYFENPSTLNPNTKYESTSYSDIGSVNPYVQTNFGNGDYRNNEAADLMGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JID0</accession>
    <name>A0ABM5JID0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497698.1">
        <property type="nucleotide sequence ID" value="XM_050641741.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641741.1">
        <property type="protein sequence ID" value="XP_050497698.1"/>
        <property type="gene ID" value="LOC126878849"/>
    </dbReference>
    <dbReference type="GeneID" id="126878849"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="139" mass="15839" checksum="A2BEA933D6BB8339" modified="2025-10-08" version="1">MCIPHCLTFPISLVSGHGTIQILLAMIGSNAEQELNLESPRKRIGVQNKKVYKGQQTSSISDQNCITEIQEIDSAPPLGFHTSKGKTDPYRLAIYLYYGQKAVVRIEDITSEEIEMKKKVFDKGVYFHQYYFIGTRKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJG4</accession>
    <name>A0ABM5JJG4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">52 kDa repressor of the inhibitor of the protein kinase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498078.1">
        <property type="nucleotide sequence ID" value="XM_050642121.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642121.1">
        <property type="protein sequence ID" value="XP_050498078.1"/>
        <property type="gene ID" value="LOC126879140"/>
    </dbReference>
    <dbReference type="GeneID" id="126879140"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="3">
        <location>
            <begin position="270"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="778"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="98118" checksum="546A69A740C66C93" modified="2025-10-08" version="1">MLILFDFHFKTISDSSNGETEGAKRDDEDKPESLTIIRDEVEVGQHEQSSLAVSQNPNFEVEVFGDPLALDSHSKSSGPTNSSSESRPTINSEGKVKELSSNHIIKDIGLYVNNKPDDYTKYLLLEEHWKPPSNYVYPYSENSKGVKRYLSKTHLENHTWLVLSELKKGLFCKYCALFAQEKAGHNKGVKLGRLVIEPLTRFKDLTGKDGDLQTHERSLYHKTCVEMGKDFLKTYKSPNKEVINQVCSERLRQVTENRERLKPIIKTIILLGRQNIPFRGHRDDGPINLDIETSAANQGNFKALLQFRVDAGDKALEKHLNTSSSRATYISKTTQNALIECCGDEIRDEILKRILESKYWSMMFDETSDLSHKEQITLVVRYLWKDAVREDFITFIDAYNAAADVNGKECKENKLSGKTLGEIVLRNVKELGLDLSYCVGIGTDGASVMTSEESGSVTKIQSEAVSAKRLPCYNHALNNSISKSNKIRSINNAVGIMKEVIHFYNQSAKRNAVLTEHVGRQLLSLCETRWVDRHDAVILFFCALPEIVDSFTEISEWKESESAKKAVLYINSITSTEFIFSCVCLVDILKRTLPLSKLLQKPNLDLNKASNAVTDTLTCLKDRRRNCDDHFTELYLEALTTSEKLGVQLKMPRVVKSQRHRENYEAETVMEYYRMSMYIPLLDNVITDLQTRFSEENLLCFDLNLLMPANMLNTNVSEKCLELNVRLQKVCQNFKTLLPSDSEVVLEGELSIWRAKWSREKEEGMKIPNCAIEVLKCCDGDMFPTVRTLLQILITLPVSVASAERSFSSLKLVKSWLRTRMVEERLNGLCLLYIHRDIEVNVENVIERYAKGGKRRLDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJP9</accession>
    <name>A0ABM5JJP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498166.1">
        <property type="nucleotide sequence ID" value="XM_050642209.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642209.1">
        <property type="protein sequence ID" value="XP_050498166.1"/>
        <property type="gene ID" value="LOC126879174"/>
    </dbReference>
    <dbReference type="GeneID" id="126879174"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="606"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="858" mass="99153" checksum="7FE81809BFE52645" modified="2025-10-08" version="1">MQRFFNEFFASDEVINRSANQRSLQSVISRYGEISRLLRLVDKVDSRTDYVMMDRRKFYKKVISEFSQVRAKRKLSFEDEIASNPTQEQQSSELTSLLDNNQPLTSIENMGDHVSSSRIFYKNHQSISKLEIHKNTDVPQIECLQNNNTDGHNTETPPTLEGIVDTVAEFQRTIDSNVIDSNVITNTMENLVAKDAASDPINIKQNTKQSKRPRLNKKTYCEFISDNEDPFFTDGSSSWSDTGNTSSDTSTHNKRPKKKIVKKTQKVSKELASKTDDIDIVGEKGKRTKRINYRKNRKDLKNRGQEYTRADGTIRSKREIKPNPCIGKKCGNGCQNVTEERRLSLFHHFWSLSSARQRDWIVNMSRRNSIKRKRSKDSGKRSFSYEYYINDNEDRRRVCQQFLLNTLDITQTYVHYTLTNSIEGSAKDDLRGKIIPANKTKETTRQSVINFIKKLPALPSHYCRKDTTKLYLPVEFRNQKNLYRIYKGEKTSEGIDYVSEKNFLNIFNTEFNIGFHIPKKDKCLKCIKFDAANTEESKAEKEDHLMEKKASKERYSFHREMSQKRTDLICTSFDLQKVLNTPHGESMLLYYSRKYAVYNLCFYENGSREGFCYIWGETEGKRGSNEIASIIQKYIDLVDARISVKHLILYSDSCPGQNKNRIILSAIHNALKNCENIVSIQMNYLLPGHTEMSVDSMHSVIEGAVKNTIVWAPSQWATVCQLARKEPKPYNISYLDHTDFKGYGTFADKYFRGNLTGKISKIRVATFKKSKINQMSVKYSMRSDEEEEIIPIIMGGINSKVVDQLYKTPLPITKTKYNDLKKLCDDQVIPKLFQKEYINLPSVTGIDTLAETDIDDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKJ7</accession>
    <name>A0ABM5JKJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050498463.1">
        <property type="nucleotide sequence ID" value="XM_050642506.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642506.1">
        <property type="protein sequence ID" value="XP_050498463.1"/>
        <property type="gene ID" value="LOC126879476"/>
    </dbReference>
    <dbReference type="GeneID" id="126879476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044980149" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="53"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="272" mass="31557" checksum="8ED30C333167F50E" modified="2025-10-08" version="1">MSKYMFLLIALILVRDIASKTVKKASAKKYNNPEESDDFYEGDIAMPESSLRNGIVGEIFRWDKGIIPYVITSRFTAEEQRIIRLAFATYHKYTCIKFIPRRPNDKYYLNITNEAKSFCFSFIGRQPTGPQLLNLGNKCFKKLGTTIHELMHAVGFWHEQSRTDRDKFVNVIMRNIKKGMESNFQKKPTDVNFGQPYDYESILHYNPKAFTSNGNYTLVPKARDQKLLKDMGQRIGLSKIDIAKINLMYNCTEKTRKILNSPKKFFVVTGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLB9</accession>
    <name>A0ABM5JLB9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498734.1">
        <property type="nucleotide sequence ID" value="XM_050642777.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642777.1">
        <property type="protein sequence ID" value="XP_050498734.1"/>
        <property type="gene ID" value="LOC126879609"/>
    </dbReference>
    <dbReference type="GeneID" id="126879609"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="765" mass="88402" checksum="7FAED74BF34F0654" modified="2025-10-08" version="1">MSTLRNNIYLVGVMKNQICGSKLPCKRDVLSVLFYNMRVVNLNLNDSSALVIDEVVVFWKKARIPVQNRSNCILKLKSLYDNVRNLEKSKNRDTERQREKENDFKEALDNLFDIATLNALNEIKIAEDREFLIKQREKGRVGCMLGVDIKLLRKEKRKEERTAAELKRKEDLLENSSCSIGHFEMEDKEHEDSQKKVINQDNSEDDIYFISEFQQGPSSNKRGRKTLMTPRLAAALDKCKVSDRDAMHIISAVLEALNIDITEFVLNRSSIKRNREILRKIKYSSIKSVGNDANFIEVHWDSKLLPDITKNEKIDRLPVIAVGLDFEQLLGVPGIASSAGSEVCSAVFHITDEWNLTEKIQAFCFDTTASNTGRIKGAAVLLQQRLGRDILWLPCRHHIFEVVLAGVFTRTKAIVTSGPEIAQFKALKENWKNIDKMKFLDYTSDEAVYNALKDVAPEIIYFVKQKLAEEQPRDDYKEFLQLTLIFLGDKTNVSFRAPGAYHLARWMAKAIYCLKLFLFRDQMKMRKDNSKLNAEICVFVVYCYVEAWFSATNTTGAPLNDIYFLRKLVIFKNINENIATIAITKFLNHLWYLSEECAAMAIFDDRIERVEKIRMAQKIMECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLM1</accession>
    <name>A0ABM5JLM1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498839.1">
        <property type="nucleotide sequence ID" value="XM_050642882.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642882.1">
        <property type="protein sequence ID" value="XP_050498839.1"/>
        <property type="gene ID" value="LOC126879699"/>
    </dbReference>
    <dbReference type="GeneID" id="126879699"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19717" checksum="2482699E8E472215" modified="2025-10-08" version="1">MKPAHLTTNELTYELHIRDVSAPDDIEEKRTVLTGLLSQETSSRSFSNISVPLSFEVDYKQALASYTELQILISEFTGTKSDILYKTFNSRFQHLSGRISRLRSSSAEEEKLKKAIRFNLLKLEGTLCNILEQPDLLDQPMTSTRVNLNCSESSISPSKPVPVYKWGIKKIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMI8</accession>
    <name>A0ABM5JMI8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499159.1">
        <property type="nucleotide sequence ID" value="XM_050643202.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643202.1">
        <property type="protein sequence ID" value="XP_050499159.1"/>
        <property type="gene ID" value="LOC114331400"/>
    </dbReference>
    <dbReference type="GeneID" id="114331400"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF396">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045861329" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="169" mass="18981" checksum="AE8286F148F515BE" modified="2025-10-08" version="1">MFSLVTFLSLFSFCLFPGSQGDTCCAATPKNTYYLGDKQVNWANAITVCQVVGMSLVSIQSKVKNDEIRKFLQTTGVNYTSFDNGIWTSGNRLQDKVHWLWLAQEPPVYTNWDTLFHEPNNATGDEECIQVINNGTSTNWNDIACKRLFYPLCEKQICCSGCNCGCSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNJ2</accession>
    <name>A0ABM5JNJ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein takeout-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499506.1">
        <property type="nucleotide sequence ID" value="XM_050643549.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643549.1">
        <property type="protein sequence ID" value="XP_050499506.1"/>
        <property type="gene ID" value="LOC126880024"/>
    </dbReference>
    <dbReference type="GeneID" id="126880024"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045672189" description="Protein takeout-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27945" checksum="C2491DBB8242DF43" modified="2025-10-08" version="1">MRWCLLILCISVGFASKLPDAIPRCSKSKPDFKECVQKSMEIGMRVLASGNKELGLLPIDPLFIKDMKISSQGSSVTLEQKYHNINVHGMTHTDIKAVKADFTDKCEYYIEVYSPALRMEGEYELNGKILVFPLNSKGKCNVTLVENNAVHAMQCERYQKNGKTYMKWTNYTIILNPTRMVYDFDNLFPANPQIENEIKKTLNDNNLAIFNEVKPSFERIFNIIYLNNGNKIMSKVPIEEMVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPT3</accession>
    <name>A0ABM5JPT3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499946.1">
        <property type="nucleotide sequence ID" value="XM_050643989.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499947.1">
        <property type="nucleotide sequence ID" value="XM_050643990.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499949.1">
        <property type="nucleotide sequence ID" value="XM_050643992.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643989.1">
        <property type="protein sequence ID" value="XP_050499946.1"/>
        <property type="gene ID" value="LOC126880206"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643990.1">
        <property type="protein sequence ID" value="XP_050499947.1"/>
        <property type="gene ID" value="LOC126880207"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643992.1">
        <property type="protein sequence ID" value="XP_050499949.1"/>
        <property type="gene ID" value="LOC126880207"/>
    </dbReference>
    <dbReference type="GeneID" id="126880206"/>
    <dbReference type="GeneID" id="126880207"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="332"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="824" mass="94473" checksum="0C15BEFE84617C6E" modified="2025-10-08" version="1">MVNLALQYLRLATQRSNIKLDIWFISRCLHNKVFPTFCRVRTSNNVHPNIRNAMQTKLMKKEICKHYSKLNYIDCKLKVTYDSLLETLHYINLNTLLSDVQDKVDRSHSVKFNRVNNKLQHLVNNKIRLDQQKASHNKSFSNFRFHPRIKNLSNVQFSDDELKLLNLGLKHSIPTNLSIRDLESLSIETDTVIQNLSISLTQKTSIRNSCIQTINKFKTKLLSNNNSSISNINSFSTSTSSSSFPNFSFNKSKSLLSTLKSIKNKIKNQHLIFSKADKGNCLVILDQQLYIDKVTSFLNNNNFNLLPVDPSKSFVSKMKNNLKQFTDFSSEYEAPYTKIPSNPLTPRLYGLPKIHKVDIPIRPVVSFINTPVSILSKFILNIIKNFINFTPQFTVLNSRQLVEKLQLVNLNPNIVMLSFDVSNLFTSVPKNESISLVNSLLLNNSVTSTTTSSIINILKICLSQDYFVFNNNFYQQPDGLAMGSCLSPFLADVFMDHLESNHITKNPEILHWFRYVDDILVLISGNSDSAHNLLHKINLIHPKITFTMELESSNSINFLDISITRLDDHFNFGIYRKPTQTDHVIHSTSNHPLSHKLSAFRSFIYRLNSIPLSTTEFNKELNIIKQIAVNNGYDPDIILKLQQKRELKLLQQSAFSSSSTTTPIYASLPFNNSKLSERVKQIISNSCDNIKISFKVNNTLNKSLTNTKDPIHYMSRSGVYRLSCSDCDATYIGRTYRSLSTRSAEHSKRDTTSAFSHHLKVNKHELKIPDGVQLIHNIQQKNTLRLDLYEDLEIVKDLKKSPNCVNRQTSLNRNFVPIHRQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ02</accession>
    <name>A0ABM5JQ02_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500022.1">
        <property type="nucleotide sequence ID" value="XM_050644065.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644065.1">
        <property type="protein sequence ID" value="XP_050500022.1"/>
        <property type="gene ID" value="LOC114330709"/>
    </dbReference>
    <dbReference type="GeneID" id="114330709"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="606" mass="68696" checksum="13B749378692AFC1" modified="2025-10-08" version="1">MTSIKKLSGFRQLSLNCDSPPNPPRRPPLKKQFSEDINDFKAWSEHDIGIKISLNNRSLRNPFIKNAWVESTQETVNDEPVIIKKCSENRRVPLNSLTRQISVDKEALLHSRQELAERLRKTAKPQEEKPNIKIFLAQNSKEQIDEYEVEKEDKINEQPKFIQPLITVNSDKHSFKLRKNAKQRTILFNTSDSSWPVPKNKSNQNSPVIVVPPTENGVLQKPETFLSTNNPNDVKAIDSVIIRPATAASKREMFQKRTNSAFNSTVVAVKETQKLRSPLIRSSSAPCKPEHLKSKLILTKHSKHSKTLKKVQMKPSVKNEKIEKLNEENPKSQKELNRTTPVQGNDVVTMVSLISPTGSDGEEEEVEESKDKNKTATNEKSAVEQKQPPKIMSLRKAAKTVSFQQSSIHAIRSFSASFPARRVSVTAAMMLNNSLNSPAKVQEKRSTNSSTPDDDERVPKRRLVRSNTEDAKSTSFEQENIDEPENDSQKESTTVSNFTVDIKSNDIENQQVENKQNVQGTEQLISEPIQKETESSKETEMETKENPDLKSPKEKQCWNMYCKMAEKGINISFDTILRGMLTPTEYRLSKKHLLAATSTEPSENVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQC5</accession>
    <name>A0ABM5JQC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyroglutamyl-peptidase 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500138.1">
        <property type="nucleotide sequence ID" value="XM_050644181.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500139.1">
        <property type="nucleotide sequence ID" value="XM_050644182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644181.1">
        <property type="protein sequence ID" value="XP_050500138.1"/>
        <property type="gene ID" value="LOC126880362"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644182.1">
        <property type="protein sequence ID" value="XP_050500139.1"/>
        <property type="gene ID" value="LOC126880362"/>
    </dbReference>
    <dbReference type="GeneID" id="126880362"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22637" checksum="2A2997CFF3CCF235" modified="2025-10-08" version="1">MKSKSVLVTGFGPFAGHAVNASWQSVQLLPDEVNGIAIIKKEIPVEYVYVESEIPQLWKEHSPMLVVHVGVSSEATNLTIEKCANREGYNKCDGAGLIHPSGLACTNGNDCIFTEIDIEAVQNSVNSSGKVQSCISDDAGRYLCEFIYYTSLNVDPARTLFVHVPPLGLPYSAQELSEGLLEIIKCALEQLTHQKDKYESAVANTCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQP6</accession>
    <name>A0ABM5JQP6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500262.1">
        <property type="nucleotide sequence ID" value="XM_050644305.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644305.1">
        <property type="protein sequence ID" value="XP_050500262.1"/>
        <property type="gene ID" value="LOC126880446"/>
    </dbReference>
    <dbReference type="GeneID" id="126880446"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="891" mass="99814" checksum="633BB71DFB25AB40" modified="2025-10-08" version="1">MPISSSAATVEKKKAFKLQNPVKSIDHNERQAEKNLLKIGPALPGKTKRNFYVRSHSTLNASAITKIHDTPVFCEAVTLRTHSDGLLHVSRVQEEKETHPDRISLDRRGLNSIPIIDGEPKLRLLSMQHNLVTTLEMIAKQSFPTLVFLDIYDNQLEQIQYLDELTNLRVLLMGKNRIKKIEGLDNLTNVEVLDLHGNQISQVGGLSSLTSLKVLNLAGNQIRIIGVKDIEGLQSLQELNLRRNRLKKLLGFAEVPNLVKLFLSNNDLQCVEDISSLAKSSNIKEISIDNNPVLLGGDCISFLVSYLPLLNKLNSMQITEQVRKAAMAWRRNKEASNSTFMDLTNDVSLTCRREEVISNARTNWEFLRSQTKCLTNNGNVVEKSLKNLKPDLDFIMTPLRKSTTTPIRPVKSKSCTKVPVLPDKKFNLLRTSSQETENSQNTSSSNEYFKLPPILVPIINKMEEKSSDQGKPGSLTSVGPNIDSSVSSVASSSEVDAAETTCSCISKESDSDNESECDVDIMAEELMKKIPRDDSLVKSTDVEECRIKNCGSADTSSVLSGVTTLSNISNPSNSSGENLSKTFTRNIRSAVHSKTIPTKCLSRAVTAKTKKQSSPALPKDREQGGDYLIEICGRHLNVYGQGALRFIDKIWNVSKAQDVTTIKFNYVNFNSVNGVLSKIKHRFPNVGHFVFKETNITCLGQLNALAETQGLTSLYIDPEGNPICEKKWESYAIFRLAHWGLKNINDKEITETDVKAANEEYQGLSDLVLWSLPDSLLQPLLVRMRIDISNNAFDQDAKKWLLNADPDLKSVISKEALQWKKPSLSQEENTIRYKAKQQISHVLDDMANAMNKLVILDEQWPNILHNFVQNTLLDYSQLDLYMKQKMQELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSB9</accession>
    <name>A0ABM5JSB9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500825.1">
        <property type="nucleotide sequence ID" value="XM_050644868.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644868.1">
        <property type="protein sequence ID" value="XP_050500825.1"/>
        <property type="gene ID" value="LOC126880806"/>
    </dbReference>
    <dbReference type="GeneID" id="126880806"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="157" mass="18380" checksum="3E324156CB76C588" modified="2025-10-08" version="1">MLIDIDETVSEDEVREAITKELNIEGTSRIDMTIKLAQKTNQRGYKFAFVTMEHDAVDLITKKKRIGEGWNRCRIRELDLLDRCRKCFQIGHIAKECQRKGSQDRCHRCGEEGHKRGQCSGEENCYLCNEKGHGAETMRCPKYRELLKRKMRRRGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSU5</accession>
    <name>A0ABM5JSU5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501000.1">
        <property type="nucleotide sequence ID" value="XM_050645043.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645043.1">
        <property type="protein sequence ID" value="XP_050501000.1"/>
        <property type="gene ID" value="LOC126880961"/>
    </dbReference>
    <dbReference type="GeneID" id="126880961"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119644" checksum="0F54D687BDD211E1" modified="2025-10-08" version="1">MADKLKKYTFQRRMAMNDLETLLRLSNSSLTEVHKQSLFRVRYSELDDVLESFNKNHQNIVTNLLNSEPTDAQLDSEDIIRSQFLNDYYQIKANFADLFENDDNSQKNEQNIAASNAVQPPSNVRLPQLELVKFSGEFTSAITFFDLFDALVHRRPNVDDTEKLTYLIQSLEGPPLRLAKSLPLARENYIRIYDKLKNRYLNKRLRAMAHWCKIEEAPATMFKNSDSYSNLIDTFSENLSALENLGYKISDFVLAYKILTKLDEETHQRFELLHWSSEMPTFIQLSDFLESQCISFDSSLLSPCSPKDSNIKNKSPSKHNANKNGSKVNNRYSFFSKPNATTCLLCSADHHLKDCSLFLNKSPYERYNACKRMRLCFKCLEKHDSRSCSVTSRCCHCNSSHHSLLHFKSSESATQGATSVAAVPTTASSDAQVNTGTLSSHAASLGSVTSKNSSVLLATAVVEIMDGCGLYQPVRALIDGGSMTSFVSQSCIRQLGIRHSSATLSVQGIGAIKSTVVGRVDLQIKPVDRVDPIFNCEAFVLPKICEDLPVVSLDVGHWSYIANLKLADPRFHLSGKVDLLLGADIFSQLLLEGKVQTPRGMPDALNTVFGYVLMGPCSSVPMTSATSLFCHVDQMVSLEESVKQFWSLETVPEVECSAPEDILCEKNFVENVCRDGSGRYTVALPFRELSPVFPGMFELAVNRFLSLEKRLLKNPSVYQEYCTFMKDYLDLHHMQLVFSPDEELQEFRLLTVTYGVSSAPFLALRTLLQLSEDEGREFPLAAEVLRTSTYVDDIVCGGDTLEIALDLRNELISLLSRGQFELRKWSSNDMRLLEGLPESHIGKKPISFDDNSCSSPLKILGLVWNAQLDCFSFEVTALDKSCTKRSMLSELARVFDPVGFLAPMTLFTKHLIQRLWLSGIDWDDSPPDSICKVWNQYKEQLLSLAQLEIPRCMFVSRYICCEERLSPNSWFYVPSAQNPADLASRGVLPALMLEQSHWFAGPEFLYNTDPIPDASCCFSECAEMLDEERTYILIASTWSILSYYPGVLSLFWLTGTIDKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTN7</accession>
    <name>A0ABM5JTN7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501303.1">
        <property type="nucleotide sequence ID" value="XM_050645346.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645346.1">
        <property type="protein sequence ID" value="XP_050501303.1"/>
        <property type="gene ID" value="LOC126881217"/>
    </dbReference>
    <dbReference type="GeneID" id="126881217"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046530270" evidence="4">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="307" mass="35528" checksum="76FBEED4F10F00DA" modified="2025-10-08" version="1">MTCKNQYIIIPLLVLVVSHSNCMSPGCNWMENEEEWQCNSISLQSPDPELAKLNPTEVLSLCLYKVYGNINPDLFTNLTSLKVLLLLETEFKTFKFKSNTLQSLQLIRNKFPRGSNIKNCCYKLEKLTLKNNTGISLKHEVLSSFKRLRSLDLILQKVKHINKHIFKGLTKLKKLSIVNCSTETIAEDAFRDLSHLQELYIEDNSLRHIHPKAFEPLKQLTSLSIYSNRLPPLPLTTFSEQKRLTQIGLPTNTWKSITVEDVPYMFPRLNFFSYMGGWKTEEDKINTKSNVFTKLTKLLLKRDENIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU82</accession>
    <name>A0ABM5JU82_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501495.1">
        <property type="nucleotide sequence ID" value="XM_050645538.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645538.1">
        <property type="protein sequence ID" value="XP_050501495.1"/>
        <property type="gene ID" value="LOC114341112"/>
    </dbReference>
    <dbReference type="GeneID" id="114341112"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="249"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="81294" checksum="96C1081AAAC12314" modified="2025-10-08" version="1">MFKYYLVALYFSLYFTAGCCEYLTYRLNPSEAVPRTYEIVIKPDLDIDVFHGQVIIYVVTKKSLNGITLHSDELNITDVYINQIKGYYVEETEGRITVKYNNGSIQPGEHTLLFKYSGKFQNESSRGLLKALYEYNGTKEYVYVTDLEPDCARKVFPCFDEPEFKAKYHIKLVSPNETYVAISNMPEIAKFRTSYGIVHEFAASVPMSTYLVSFAFTNFPYYSENFEYQGRQIPIRIFTVNASKENNEFAMQCVKTAFSFYSEYTDISYPLPKLDMIEYQRVETAATENWGLITFREGILTAPLGIYNEFQIKLVVFHELSHFWFGNLVTNAWWNDIWLQEGFASYMSYKLSAKDNNETQLNEMKFFSFNDFFETEIYEKSQPIVQYLPDPSKLIDVFFGVVYEKAPAILLMLEDQVGQKKFREISRKFLKKHAYHTATTNDFITVVEDVVPDIPLRTFLESYLYQHKFPVLNVDIVDNMTYVITQQVCETFHQEQISATKWTIPISYRTDYSNDSKHIWFHREMDELRLEESDAKWIIFNPEGNQMYKTIWSTNLWNKIISNIEFMDNSTTDTVISDALYSFRFNKIKCETVIHLMKRFGTGHKERWELFFPLYDHIKENLFCHKYTEESKLLWKFQNKRYAETNHKQMPKFREPESCDDISIIQNEDYRNHLAQCATWLRKNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVX3</accession>
    <name>A0ABM5JVX3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502089.1">
        <property type="nucleotide sequence ID" value="XM_050646132.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646132.1">
        <property type="protein sequence ID" value="XP_050502089.1"/>
        <property type="gene ID" value="LOC126881712"/>
    </dbReference>
    <dbReference type="GeneID" id="126881712"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66711" checksum="376236C9F27B5C5F" modified="2025-10-08" version="1">MKADKISATAKNDILICLFGENHLKKHKRKQIVTVTSNKMRELARLLIALREFTPVQNLIDAMKPELFDDLVTATKVISGFSNADKSFKSSSLALHMGTTLKQVCDIINRMILKKSPLFTFKNPNEEKKSIRDLKTLLETSWANEISSLALKTMKEQQWEKPQILPVTSDVIKFNNFVKNQFEDSAKKLNKLLEKEGKQNDKNDLLPLYKTLAKGIMALLLILNRNRIGEIQYLEISTYKRSFAEPSVQKEIAESLTVSEKLLCRNFRRIITGGKGSKPVAILMSPFLNEKIELMIKIREKIKLIPEDNKYIFANPNSSKGWFHGTSVIKQFAQNCGAKDPNSLTSTKFRKQTATILQIMDINNTDMEQLAIFMGHTKKTHEEWYRLPQDLYQTAKIAKLMIALNKGDVNIYKGKSLDDINIEENDYLEIENIETEVNEINEKELTEPTHSWSPKSNFSDVTDEKIEQANKNEKVSSKGKRKLFTDEMTHPMQNNKVTKRKEVPTTEKTESTSNAIARHRWTEKDKQTMLKYFTRFIKEKRVPKKADVQKLKKNKAGENFQSIDWVKIKTFVYNSYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY88</accession>
    <name>A0ABM5JY88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein nessun dorma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502908.1">
        <property type="nucleotide sequence ID" value="XM_050646951.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646951.1">
        <property type="protein sequence ID" value="XP_050502908.1"/>
        <property type="gene ID" value="LOC126882103"/>
    </dbReference>
    <dbReference type="GeneID" id="126882103"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057508">
        <property type="entry name" value="SHCBP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045140">
        <property type="entry name" value="SHCBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695:SF4">
        <property type="entry name" value="PROTEIN NESSUN DORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695">
        <property type="entry name" value="SHC SH2-DOMAIN BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23762">
        <property type="entry name" value="SHCBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHC SH2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="5">
        <location>
            <begin position="384"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="62601" checksum="D2CE7664FF7988CD" modified="2025-10-08" version="1">MDKIITFDKSFQQRYTEFNEVLSNYTLLPSLHLKKQWGFFIELTVDKIGWQAVWKIPRLKCEALGIPFPSVVLVIVLTINTKELKALVRILAVQDDIYIPEKHWVPLIQLWPTEEQDKSIALGLMQTANSLDMLRFFYLYVYMPWDRDEDVNIDWKETHLESRLRFYYDLKNGTIPRAVAEHIHCLLTEARRMQNKREFIENQLTQQEESEEFNKDTSAEKRTRALMEIHVHLLEIRTEIEIAENPLLREIIIERYSQLDQISKNTDPQIWLIFDQGTADEHIDFLTEVKSLYPKDNLKFCTNLASKLESANTKDTYLINESSHNIFTTGALEKGGVLRGIGSSNKVIITSDIEDVMLDFKSELVVLENLTIDAKSAQCAILVRQGNCILKNCKITGKGNSSIHQGIIVLKGAHLELENCELSGFSTAITGNSDCKVVLKDCDIYDADVGIKIFDGCSMKLEKVNIRECMEFGFILETDEKTATIGNFENLSLIPEIEHVEVEGSNNTRGDVAILQRPKLKPVKDLFANPDNDPTIIESDTEETLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYI1</accession>
    <name>A0ABM5JYI1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502994.1">
        <property type="nucleotide sequence ID" value="XM_050647037.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647037.1">
        <property type="protein sequence ID" value="XP_050502994.1"/>
        <property type="gene ID" value="LOC126882226"/>
    </dbReference>
    <dbReference type="GeneID" id="126882226"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF165">
        <property type="entry name" value="ZINC FINGER PROTEIN 555-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="787" mass="92441" checksum="6E1632112240422E" modified="2025-10-08" version="1">MELSEDSIKRKQYGDFLGQYVNVQIKSELEECRFESNHTEDSVSDSYCSHNIKIDDHNMLQYDISNPFPFITMQGVKTEIKKELDEHNLEVNHGCDTLFKTTDTEKLDSEGVVKLQIGDSFEIDHAKHCTSTKTTKLLSKIDKEKSSLLDLYCSDNIKIEEHMLQFDVINPFPVITMQEVKTEIKKELDEPNLEVNHECDAVFKSIDTEKLDSEGDVKLQIGDSFDTDHETAELLSKIDKKSLRQNENQMKSEGSLETYTRENSYKCEICLREFTAFRYLKRHMLIHTGERPYKCKICYREFSQDGNLKRHLRIHTGEKPSYNCEICFRQFSEAGNLKNHLRIHTDKKHYKCEICSKQFNRNHSLKKHLRIHTDEKPYNCEICFRQFSEAGTLKNHLRIHTGQRHYKCEICFKQFSQGRHLKNHLRKHTGEKHLRIHTDENTNKCEICLKQFSQPGILKKHLIIHTGAKPYKCEICSKQFSRGDSLKKHIRIHAGEKPYKCEICFKQFSETGTLKKHLKLHTGEKVYQCEICSKQFSRDDSLKKHLRIHTGEKPYKCKICFKQFSEAGTLKRHLKIHTGENPCNCEICFKQFSKAGSLKKHLKIHTGEKPYKCEICCKQFSEKGILNNHLRMHTGEKPYGCEICSKQFSRDDNLKKHLRIHTGEKPYKCEICFKQFSEKGTLNNHLRMHTGEKPYRCEICSKQFSRDDNLKKHLRIHTGEKPYKCEICFKQFSEKGTLNNHLRMHTGEKPYRCEICSKQFSRDDNLKKHLRIHTGEKPSSSSWHLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYS8</accession>
    <name>A0ABM5JYS8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503089.1">
        <property type="nucleotide sequence ID" value="XM_050647132.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503090.1">
        <property type="nucleotide sequence ID" value="XM_050647133.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503099.1">
        <property type="nucleotide sequence ID" value="XM_050647142.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647132.1">
        <property type="protein sequence ID" value="XP_050503089.1"/>
        <property type="gene ID" value="LOC114338004"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647133.1">
        <property type="protein sequence ID" value="XP_050503090.1"/>
        <property type="gene ID" value="LOC114338004"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647142.1">
        <property type="protein sequence ID" value="XP_050503099.1"/>
        <property type="gene ID" value="LOC114338004"/>
    </dbReference>
    <dbReference type="GeneID" id="114338004"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09445">
        <property type="entry name" value="LIM_Mical_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="707"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="1297"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="873"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1382" mass="159311" checksum="0D1A1DCE800A66CC" modified="2025-10-08" version="1">MAETVKKSRIVSDEEENLEEALLEEFNMRLKNCMSKDDLQEADQYPEDNFYENISNNIRPVPKSGIASNDFIENERHQYYDTPVITLNLKNGSSETQNGHDVEDENLYETLPEPSKTELTDQSPETPKLNLNLDLSPKIEVANEYEIINKEIDKETTERPEFSLNTTDFSELHLSQEENVKSVKDRMLLMTDDAATLLFTQTVTSPMLTPSEENIDFLKGFQRENTNSDESASNEIPKDDKEDKEDKEEENTASEVSAEISTSEPPVNTSTQEEVKVYENSENIYENLKEPINENIYENLKEVKDKVEELANYDEHIYQDIEDYPKDLYEPVEDPVKNDEFMVENSLYNKLDELTQFHNDEIVTDLDAVENDIEDEPVDNNYEVISEDEPEPTKESPEEIIRENHIDEIKKEEVEYESITDSNTEESLDSKTKETYTEFLYHSKTESNYYEKYTEVVSKNTEISNREKDTETVPAEIVKNLKSQFLKGDAELVSAVSKKEIEDVSQLKMVNIIKQINKFELKDNGEAADDDSTVTETYTETTTIQSDTPEEKVLKKKKTKKSRKEEKENISVNGDLVNGDYCYNVNVRNLCRSFGDLTKIPDDTRSKSSSIWNTGRSKSLSDVLLSSNKKNIENVFSEVSVRALKEKFNIFENKDPLGIVKPTFKNPVMKSSFSKFDALQKKNVLHIRSSDSAKAQEKFNGTQIDMTNCKACAKQVFQMEQIKAEKAVWHKNCFRCTECSKQLTVETYASHEGTLYCKPHFKSLFAPKAVEDDTPSRPRKPELIIRENQPLELPPDVVRASDKPDLGLEELQSLNVKERFQVFQQTQSETQEMDRGPTPVNVKKSPSILSKLARFQAKGMDVGVSDEALNGIPIEESSSEAEEEEEEVPEGEDPTLYRAKRVQKEKPFHFTNLNEVKNKWEQGEQNSKDERREERKQEIQSIRNKLFLGKQGKMKEAYQQAVIQSESCTNLVKSEKIESCDTKSLKERFEKGELVIEREDSRNGDSDDTEVFQSEISKKSRSLFLELDANAAKQPQSISPVAVPKVDVKKAREAYSKSVSEDVVKSSEIEEVIEVKTADIQERFKFFETYREPEKERKQFRITPPRDPSQVKSDTPDREIYHDPEIIRSDEIADDSEVARASHTASKMLSKFKQMEENFSRDPEPQGPKPLKRFTPPPEPTRTESESEEGSATEEENEEEEEDQTDNNKLPEDLIEAQKAARARQLRAKFEKWEAQEIKREQNQSVNVIEEYGDESQVESTKSLRARFESMRETSSDKTRTPRVKVNRFVEIPNVTELCYSCEEKVYPLEKISVHGHTYHKRCFKCMECSCILRMDSYSYNKGLLYCTPHFKRLFISKGNYDTGFGFDQHKEKWNNVNATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K369</accession>
    <name>A0ABM5K369_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-secretase-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504633.1">
        <property type="nucleotide sequence ID" value="XM_050648676.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648676.1">
        <property type="protein sequence ID" value="XP_050504633.1"/>
        <property type="gene ID" value="LOC114326805"/>
    </dbReference>
    <dbReference type="GeneID" id="114326805"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="676"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="891" mass="101739" checksum="F6B58BB150DD573C" modified="2025-10-08" version="1">MVSVDNLASKLVSIISTENNVDSYNEWRLLGQERDESFLFSWVQTNPDENKSQTCIGEYNYEENTLTPLYSFEKKVDCVQASMNAARTVLLFVLKEKCEETEELIYRSYLYKIDDLLENAFVIKNGSKNQTFVQFLNFNSPVETQSLKFLLLIHQEGIYQYQIKPSDDTIKKESLTSELLVKNFFWAQWDACEQTLYYIHNKHRNRGLVAGEEITVDDNTKVIPTLTGLQFHDDQPHESVLNIPLNLPHLSTFNSSATYEDDVVPLRIHDSSLDLIVLTNPTGCVCICHNYLYQPIQPTVSLEDDDHTTPINFAYSVTALHQSCVIHCVINDIPWNKAKTIRPLFKLRGDSLIVFIPEICTHVLDVGLLHEPVCHVTTNPLISDKEPHLLYLAPLISADDYIINLSNLDIIDVSLLENLMIETFKSDTILENKIAILHYLLVHMEDVETASELICWHSATPFTIDYPELLKEFLLATSYASVQKNLPLNAAKLATLLPITTLRLGFDMELKNNDYLINLRQEVLWNASMMVISPQLRITPYKSDLWVKLWDHLAKLSKPGLRFRSSQVLDKLRISLDCYQPEALSRCSTPLSPSGGAASTFADFLSGTRNQTDFLPFYEMDSCTASRQEHIISVNLRELSMHLLKQTSDTTRKFQMADQSAMHVHAVATRYVGAQLEQSRQLCQIVCKAATYDPAEDVDKGFILINNLEEDRRYIFFKLLEKYYMAVESLAFPLPQGFTSFFTYLGYRTMEFEMFEQYVVNHVCELQVDVMKIILAEEDESKENTAKKLKLLSLLPRQRAKRLLNQWNHPIGVVLRAREHAYNILSGVTGLPTRSRNQNLPSIKGLGSFSSSNNMSPLDTFLDLLTAKASLTDIDFGLLIEATETYIEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4I8</accession>
    <name>A0ABM5K4I8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144311.2">
        <property type="nucleotide sequence ID" value="XM_028288510.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505105.1">
        <property type="nucleotide sequence ID" value="XM_050649148.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505106.1">
        <property type="nucleotide sequence ID" value="XM_050649149.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505107.1">
        <property type="nucleotide sequence ID" value="XM_050649150.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288510.2">
        <property type="protein sequence ID" value="XP_028144311.2"/>
        <property type="gene ID" value="LOC114337927"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649148.1">
        <property type="protein sequence ID" value="XP_050505105.1"/>
        <property type="gene ID" value="LOC114337927"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649149.1">
        <property type="protein sequence ID" value="XP_050505106.1"/>
        <property type="gene ID" value="LOC114337927"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649150.1">
        <property type="protein sequence ID" value="XP_050505107.1"/>
        <property type="gene ID" value="LOC114337927"/>
    </dbReference>
    <dbReference type="GeneID" id="114337927"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028459" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="164"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25156" checksum="D17DCBF351340115" modified="2025-10-08" version="1">MHCSSIIFVAVLFVGGTIAQDPDCEKQQYWPDVYDCTKYYECNTQGEKVEMSCPSGLYWNPLLLTCDRPENVDCSWTVGPTESTAPPTPAPTTANPTGTTIPPWLRCDVNGEYFPDTTNCQAFYECINNVKQHMICPDPLLWNVHLPGCTESSDCSQIETSTTPASCTNGDMKADVNSCHYFYICESNQWEGPIQCPVELYWSASKRGCVKIEDSDCPGHTTVGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K528</accession>
    <name>A0ABM5K528_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505289.1">
        <property type="nucleotide sequence ID" value="XM_050649332.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649332.1">
        <property type="protein sequence ID" value="XP_050505289.1"/>
        <property type="gene ID" value="LOC114345565"/>
    </dbReference>
    <dbReference type="GeneID" id="114345565"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="825" mass="94112" checksum="226F58A70B5B9A0B" modified="2025-10-08" version="1">MSSPPTEIITVHQVKGKPVDDTIEEFEEKNDTTSEETNIFLCILYRFGKLGVAYYNLVDKQLYVYDEMVDEKPQYLVTVGIFREIKPKYVLTMGGRNEEFTKVLIDIINYGDSYQNSTTTSDTVQSLPPNLFIATAKEYTYEICKAIISQLSLAAIEEEPSTTKREVYIHSLINFDNRLPLQAIGTLVKFLDKNWSFFGITDKDELSYIHINQVTRKDQVLIDNSTFEALQIFSKRGHESGFKRGLHSSDREGLSVYKLFSVNCKSTVGLVTLRNILLNPLKNIDLLNQRLDFISFVLLPNNRFFVESLRENLQEISGDINVILTRIGNSRAKFRDWYVLYKAIYYTVYINELSAPYRENSSLLFDLNEKISSNLISLEESIKNGLDFEASKKRGKPIVRSGLDEDLDEKKLRRQGIMNDVMAAARFAADNLPDFLDECSVVYLPEMGHLLAIKEWKPDCQPEDLQNLGFQFVFKLGGKFHYKNAMCVELDKRLGDIYLEIIDHENRILRRLSGFILKYNKDIREPLKIIGMIDSLIAIAITASCKMYIRPFLNTNNYFQLDECRHPLLEHMLDQFQPNDFYSGANNSHIKIITGPNGSGKSVYLKQICLVVYLAHVGSYVPCSRADINLLDTIHSRVLAMESAVVRLSSFMIDVTQMNNTLTDPAASSLVLIDEFGKGTSETEGICLLQGALEHFLDRGDACPHVLVSTHFQQIHKRLPDSPLVQYQKMEHTKESGVLYFLYKISEGISNSYAFDVAEEIGIDKKTIDRAKEIFDCLSNSKPLAPLPQLLARNKFDMTTLQILDIPEPDEGSEITNINLHELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5H1</accession>
    <name>A0ABM5K5H1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050505433.1">
        <property type="nucleotide sequence ID" value="XM_050649476.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649476.1">
        <property type="protein sequence ID" value="XP_050505433.1"/>
        <property type="gene ID" value="LOC126883806"/>
    </dbReference>
    <dbReference type="GeneID" id="126883806"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
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        </source>
    </evidence>
    <sequence length="2874" mass="309260" checksum="1E8375A4B1ED5926" modified="2025-10-08" version="1">MWRPQGSAMLAWTRLAEPGPALLFFVLVFAPQFASSAPLENENEQSTDIEYYPVADATGCYYNFEHYDEGDRIITNEPCLNCTCHNRMLMCYLRVCPFTKAIGQDCKVEKKPDQCCPTITCPEVPVQLVPHASTTPSTAIGHLNEYGCSIDNLFYADGAKVPSNPNNPCEVCYCIRNKTACIIQECTLTGKLVEGCKPVYLEGVCCPLRYDCDHPEYPQIETTARPLLTTTTTEVPTTTLIPTTTAIPTHCTYNNEKYLDGALVKKDVPCEKCYCMRGDIVCAVQECGPTPLDKVNCTALPRKEGHCCPDTYDCNMVSEEDLTTISSYEAPTTQPTIVTPESQTSKPEEVVTPELKDRGEFSTDAAETKPETTTERLTSIVTEVVTEISQTISSIVFGTTEEPKKTDKSEEPLTESSPEPTKQPEIPETPTEKTQEVTEVPIEKVTEPAQHETIAHDETEEPEEPEDHQTSTVASKESSTALPSGFEDERTRPIDKEGETRQPTVQEPSKEGEESTTKLPKDTTESETDKSTYADITPQETTVVKEEVTTQRVAISEGATISKTAETTKLPEEAPVTTEKAKETELPKSETTEGPKESQEPTDVTSEQPIGTEGTKDTPAPADIPSESSKPEESQTETSKSDVTSEPETHKATDAIKLDTTTESRPTGQPGVTRLEPIETQSPEREPTTEETHEATEEYQETTEKVQESTQKAQDLTENTQASSEKSQETQSPRDVTTEPITSVTQSEVADETSEEPKDTQPSHSTEEPNKPTEEKAPTESGITTELPKGTPADNKDVTSEQTETKSQSTETQPSKPDATTETSLETQTITEKVEPVETLPSKTKATTERIQESEATKASPSEVSDETEPTKAPSVEGSQETDHPTELTTQKSEETEAPKVSSTEEPEGTEQSKAPSTDRSQETESPNEQPIETQPPKSLPTEEPTKAESDEPTKESSTEGAKETEPSKVTTTEGPKETKPVTETPTTKAAELTTVEEMEIVTSAPLNETEKPLSMDHKSETIVPTKAQPPETTKSAETATEAPAVQTTEPPKAEVPPTQETVKESNEIPEAVCTKETCGTQDQAPSSTEKPTPVEKDHTESNQIPEGPLKETTEGETQKPLDITDKTPAVSETEGPAVGTTTEAELLTTKPQDKQTVPSESTAHESTTHKDISESSTEVKLPEVTTESQAETTSHDIRENEIIPSVTTDKQPQETESTESQTAKSETTQEPIGETKQPEPVTTLNEITTQSAPAVHSEQTKSAEATTDSTTRPESSTDATSEPITVIPSKPSETATQHDESPDVTATELPEEPEVTTIEERVHGIPGEGSCLVEGRTYNNNSNVPPFNHCQVACKCVSSILKCSHVPCPDPPKDDCVPVVPRPENSCCPVYQCDMESSSQVIETTTPSLEESATTAAKSTGLPEDETKSPETVTTLSTSGSEDTEKSTTAASVTSQDDVTENEITEPVIKVESCSGEACAPSQPSESTSIPEQVTEAQKEGETCTGEECAPSKTDDSTKPVEQTTEEGESCTGEGCTPSKSGESTPPVEQVTETQKEGEGCTGEECAPPKSSEITPPVEQVTETQKTGESCTEEGCAPSKSGEVTPSVDEVTERQHQGEGCTEEGCTPSKSSETVPPVEQVTETQKEGESCTEEGCVPSKSGETVPPVEQVTETQTEGESCTDEGCAPSKSGETVPPVEQVTETQTEGETCTDEGCAPSKSGETVPPVEQVTETQKEGESCTDEGCEPSKSGETVPPVEQVTETQKEGESCTEEGCAPSKSGETVPPVEQVTETEKEGESCTEEGCAPSKSGETVQPVEQVTETQTEGESCTEEGCAPSKSGATVPPVEQVTETQKEGESCTGEGCVPSKSTETVPPVEHVTETQKEGESCTGEGCVPSKSSETVPPVEQVTETQKGETCTGEGCAPSKSSEPVPPVEQSTEVQTEGETTTVKQTPETSESSTIKSEGQHDDTEAQETPTVRIPVDKVPEVTTEKATEVTTEIRITPSTESVKPEETTTKSEDNKTESDVVTPLIGSTEESIPITTDKNVETTSKSTEITDAPVTTKVAPEESSKGTVEPTEVLPTDKPKEPTSSDTTTSEQLPTKAPEETLVTDEIPKETESSQKPKETEPSTESTVKLTETEGPTVSSNEPSKEVTPTSEQETKKTSTEPSTDYTVTETIESDRPLDSGAHITETTSSTSTEQSSKPSVETEAPVTQKDEGEEGTTINAVTQSQPISGSTEGSPTENEQEVTTDNVKEQTQSETKAEVTTIGSTKAEPEAVTKEQTTVTSTKSQAENTEEATTIGLTKLEGDKKEEPTTVGTTKLDEDNKEQPTTIGTTKLDEDNKEQPTTIGTTKLEEDKKEEGTTIGTTKLQHDINEEPTTVSSTKEESDVTTGASAQTEKSVTLPTKESETQGTEKAESTTIAASKPSETTLGQETTEQAGITEATIKPTQPPSDDSVTEVKASEPVQTTSVEPETATEQKVPVTESSSQSPVTEQKTNEPEVTTPELRVPVTEQSSQPSSTEQKTQESEGTTRPIVSEEQPIEVEPTVEGKPAEAEQTTTEGRIETTSRTVTEPESAHSTSIDEEPITVHIDDRLKPEVSNASTERQPVRTTSPVDVKPETEAPQISESPKNDTSELFTSGPHQEGTTRIYPVDGELSTSHPLTPLSTEHPTTLEPAHAHIPGEHEHVPDLPDYHSPGEDYDDEEPSPLGPGTCRYGGKVFVSAQQIPRDDPCDFCFCFRSDIICLQQSCPPPIPNCHEEPIRGFCCPRYECPVAMATALNFTTTTTTTTTTLPPHFLAHAYRGRATKVGCQIKGQAYNVGDFIRSASGPCMHCTCGGDGQMQCDPKQCSPEPMLRQMIQAVSKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7P0</accession>
    <name>A0ABM5K7P0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506203.1">
        <property type="nucleotide sequence ID" value="XM_050650246.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650246.1">
        <property type="protein sequence ID" value="XP_050506203.1"/>
        <property type="gene ID" value="LOC126884309"/>
    </dbReference>
    <dbReference type="GeneID" id="126884309"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="609" mass="70603" checksum="5DD77A8C739A6127" modified="2025-10-08" version="1">MAFNILAELKEEPLIEEINKTVISHIAIKNEETDYLSDNPDFIELGGETESINIKKNCSKTNQISDPLQNHASSQEGGYNGCESSSANIENISREITNLDELEEDENGRNKNCELPKDIVESRLTHFMLDDSEDSTQDTTRTYSDQDWSEHENGVYKCKICSEQFTEAVYLQQHFKDRRIGDKSYKCCGCTKVFRDTTQLNVHSRKHTGEKPYACTVCDKKFSVNGNLSKHMRIHTGERRFECFTCQRKFTQFAHLEDHIKTHSGDRPYVCDFCNSAFKTPARLRKHKKSHEEQHVSKRSVPCPVCSKVMKSTKQLLTHMNTHDEGPHNPFPCDKCKKSYKNLFSLNLHLKIHGNIRDYQCMLCDKAFTNASHLRRHSNSHTGLRPFVCNICMRGFPCSQNLKRHMMTHTGEKPFCCELCNRRFLTFENLNRHKRTHTGEKPFSCNICGRLFAHSTTAKEHIRIHTGEKPFSCPFCIKSFALNKALYKHVRQNHPFDFDEFKRENDLPLNMRKAKEKLRREARDRLKRETMSIEETERLKQLITNEPVMIKSEPDDVIVETKTNEGGIRPFMETLQLKPVDIKLEIDSDIVEDCSSLIIKTENDESDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8T3</accession>
    <name>A0ABM5K8T3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506598.1">
        <property type="nucleotide sequence ID" value="XM_050650641.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650641.1">
        <property type="protein sequence ID" value="XP_050506598.1"/>
        <property type="gene ID" value="LOC114325573"/>
    </dbReference>
    <dbReference type="GeneID" id="114325573"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="517" mass="58443" checksum="06B36C7E50341ECE" modified="2025-10-08" version="1">MNFLKIIGQFTTDSGFADVWLDSGLYAQSTIDGILSGKKYNKAIRAHKLTYEAVSRLLITLYKKWLLGCASPSVYLPPRTIGRFTDAARNTPRQSHARTISRKLQFKIVISLPIFELLYRLFNIIVNLFSVYLCKTMLIHEKMSQGIISPPSTPPLKNISDDEHMQQSTILQLRNFLGQKRTIQTSGLLTPQPSDSEPEEHDIPLKKRYRISNLEIPYPPPTITPPKSPSKTPPLYPPPTPSPIPLIKSTSPIFPKPNVVPQQTYAPVQIFFPPSPPVAPVAKPQPTPTRSVSVIMKANKTGICTSLPIPQLKEKGEENLLKSLKFKMGKNKERVKSCEKDVSREEKEEAKPEPVVTQKISLPILAPKLISPATPNTIFISADGTVLPTQFVLITHTPPATVPTRRRVYECKYEGCGKNYFKSSHLKAHNRIHTGEKPFVCQWADCGRRFSRSDELSRHKRTHTGEKKFKCSHCQRKFMRSDHLAKHVKRHTKERLNTQKVNVMPVLRPIQPAPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAM4</accession>
    <name>A0ABM5KAM4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein twisted gastrulation</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the twisted gastrulation protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507238.1">
        <property type="nucleotide sequence ID" value="XM_050651281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507239.1">
        <property type="nucleotide sequence ID" value="XM_050651282.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507240.1">
        <property type="nucleotide sequence ID" value="XM_050651283.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507241.1">
        <property type="nucleotide sequence ID" value="XM_050651284.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651281.1">
        <property type="protein sequence ID" value="XP_050507238.1"/>
        <property type="gene ID" value="LOC126884930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651282.1">
        <property type="protein sequence ID" value="XP_050507239.1"/>
        <property type="gene ID" value="LOC126884930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651283.1">
        <property type="protein sequence ID" value="XP_050507240.1"/>
        <property type="gene ID" value="LOC126884930"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651284.1">
        <property type="protein sequence ID" value="XP_050507241.1"/>
        <property type="gene ID" value="LOC126884930"/>
    </dbReference>
    <dbReference type="GeneID" id="126884930"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006761">
        <property type="entry name" value="Tsg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057726">
        <property type="entry name" value="Tsg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057635">
        <property type="entry name" value="Tsg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312">
        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312:SF16">
        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04668">
        <property type="entry name" value="Tsg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23782">
        <property type="entry name" value="Tsg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028471" description="Protein twisted gastrulation" evidence="8">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tsg N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Tsg C-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28172" checksum="9F13869A0A2EE778" modified="2025-10-08" version="1">MLIQFVPLALLTASLFLLIDTGESCNEAVCGSVVSKCLLTKSCNCDLKNCTCCKECINCLSYLYSECCSCVDICPKPNDTATDLSRKSHVEEFDEGVPQLFSLLTDFPDTYKRWDSKSFPIDMELNYYEPKKEIKISMLSVEQEVDPAKQNTITVNCTVAFWAQCMSWRKCKTSCQSMGASSYRWFHDGCCECVGEYCIKYGINESRCSECPQSEESKQDSDDNEDDYDYGEHDEDDEDDDFHNSPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC42</accession>
    <name>A0ABM5KC42_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507758.1">
        <property type="nucleotide sequence ID" value="XM_050651801.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651801.1">
        <property type="protein sequence ID" value="XP_050507758.1"/>
        <property type="gene ID" value="LOC126885291"/>
    </dbReference>
    <dbReference type="GeneID" id="126885291"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00240">
        <property type="entry name" value="TFIIFa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="58613" checksum="72B65B072AD467D6" modified="2025-10-08" version="1">MQTAKASTTPGQSPTVNVQEFSIRVPKNVQKRYHVMRFNGTLDVDFEKWTKVSMERENNMKEFKGVDEEVPKFGAGSEFGREAKEEARRKKLGIVARKYKAEDQPWILKSYGSTVKKFKGIREGGVSNNTAYYVFTHAEDGAIEAFPLQEWYKFQPIQRYKALSAEEAEMEFSKRNKHLNYFSLMLRKRLKGEEETELDEGEEKSKKSTSKKEKELKISEMDEWMDSSDDESSAEEEKEDSEEADKKKKAKKVVPKKNKKRDTDAEAFEDSDDGDGEGRELDYISDSSDSEPENINLDGVAEEKALRKLLNSDEESDEDSEKSEKEQSNEDEEKDKEGEKKEDADEKDKKKKKKKPKKDAKKEKKESKNDDNDFSSDSTSEDESKKNKKEEKKVKKEEKELSSENSSRSATPTDNKRKLINDALAGPSPKKVKMDLPNFIPGSNESGITEDAVRKYLMRKPMTTTELLQKFKSKKTGLSSEQLVNIMTQILKKINPVKQTLKGKMYLSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD75</accession>
    <name>A0ABM5KD75_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508139.1">
        <property type="nucleotide sequence ID" value="XM_050652182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652182.1">
        <property type="protein sequence ID" value="XP_050508139.1"/>
        <property type="gene ID" value="LOC126885587"/>
    </dbReference>
    <dbReference type="GeneID" id="126885587"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41946" checksum="51E09F13DD85DF08" modified="2025-10-08" version="1">MGVIKEVCAFFHKSAKRTEVLKLTITECCPEQKKNKLISLCETRWVERHDSVLLFKELLEPVSLSLLKIEEESSDSAPKAHALGSSITQFQFLVNTFVLSHMLSKTHNLSENLQKKNLDLTQAVKNVSNVLDLLSKERENADNNFKVLYSQIQERADKLKIKEEVPRICRLQTARNNVPYSTQEEYYRRAVYLPYLDDFCNSLKERFESHKETVASLQNILPEFCIKTDFCALEPAFNSYEEDLSHKEVVESEFMLWKERWSQEKYENLPKSAVSSLEKCDQDFFPNIYVLLKLLAVLPVSVATVERSFSSLRRLKTYLRNSTSENRLNGLALLSIHRDFAITNEEVLDKFASVPRNLDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD90</accession>
    <name>A0ABM5KD90_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508154.1">
        <property type="nucleotide sequence ID" value="XM_050652197.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652197.1">
        <property type="protein sequence ID" value="XP_050508154.1"/>
        <property type="gene ID" value="LOC126885598"/>
    </dbReference>
    <dbReference type="GeneID" id="126885598"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="651" mass="75023" checksum="2F1FC13348F61840" modified="2025-10-08" version="1">MSTNKHNSEQTGVSEDDHRRDTENGTDMENENRKKQSPDDLKWEEGMNSFERELINSHKKKQKMNRSTAPKQSTLVGDEMLESSENDDDEIGEERSQEEVEKIEKGWQNIQERVLASFLLDDETMNKKKRKGDSLERINDLKRERLEESIKFPNETKQQKINRKLEELNIKLIEIFTNLSEKKGEKVEMDTELKKLLGVIKSTNNKKEDDSIAEKTQQEVKCDHCKLKVEQERQREEQEKIKRALNMGGGKKTFMSICNSKWEEKAYIKTNWEQGGLRETVEKKTCLIVTKKDAKDKGVENIIKDVGEDLAETLEEVNEGEIKFLENFRRKENKKTIWYTFVAGIEKESGGDIYDLAEKAITKIKKEMDETPKVVRVVAGNDLNKEIIRKALEYVGRRESISWEMIVRGKELEVEKKSEQEEALLIKMGGKKYNEVLSEMREKIDIGKIGLQVEKLKRTNGGDLLVKLKGRGAAEKLRAELDSKMNGMDTAIRRKETFFTITRLDPGVGEETLKKMIKSYTGVPEREIEVKVLRTNRYGEQVATIAVRPSIAEELRRYGSIKIGWVVCPIMERHNPVRCFKCLKFGHNTYECKEESRAACCYNCLQTGHTVASCGNKPYCSVCKEEGHRMDRMACPSYRALVYGRGGEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDN4</accession>
    <name>A0ABM5KDN4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508305.1">
        <property type="nucleotide sequence ID" value="XM_050652348.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652348.1">
        <property type="protein sequence ID" value="XP_050508305.1"/>
        <property type="gene ID" value="LOC114325990"/>
    </dbReference>
    <dbReference type="GeneID" id="114325990"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="399" mass="46010" checksum="1E511CFC7FF66E12" modified="2025-10-08" version="1">MALIYPEEGEYRMNRDYLEYIRKCLQVHGFEGRKKYIWHATSMFITLLLFGRLSYAFRLITEPKMLVEIVVTYPLGIMAVFKLHMLYFDRKRVQYFYNTISNEFWAYHIAGPKPEAEIKRKHFLVYLLFVCEVGGSLTILFFLCIIPIVDMPGGKLPLPFVNWTKFDIFDSSPIQEIFRVIMIWNLGLSVLSNMFFDALFFYGVEHLIGQLILLKVLLENIAKDIMEEKDDCEKFSSNEFQMKVYGRLRLCIDHHVKLLKFGKNLEEFCSAILLPQLLMIYVLLVIIGFVISISNNELAKVFILSCISTASVIELAVYAIPASDLQVECLSVMDSIKCSDWYLFRAPLKKALTFMLMISKDPILIKAGGLYVIDNPVIIEVVQKAFSAIVLLRAITGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFC8</accession>
    <name>A0ABM5KFC8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508894.1">
        <property type="nucleotide sequence ID" value="XM_050652937.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652937.1">
        <property type="protein sequence ID" value="XP_050508894.1"/>
        <property type="gene ID" value="LOC126886094"/>
    </dbReference>
    <dbReference type="GeneID" id="126886094"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="370" mass="42939" checksum="16C2FAD06D4390F6" modified="2025-10-08" version="1">MTTVYENQEHSDSVVMPPIFDIYRKPMFDESIRKAEYRTYAPFIKSFNCNDIVEFSINQVDSFFEMSETLLCIKGSLVDKAGSGTITLANNVGAFLFDSCTYSESAREMETVRDPGIVSAVRAMTCYNQEDSKYMVMAGWNYPNNPILNDTSFNIQMPLKHIFNIFNDYPMITCGRQTIRLVRARHDNDCLIITDVATTAKINITNIELRVKHIYPNDEIKLQLMTSIQEDRPIVIPFRKWELHELPTITKGARREVWAVKTSTSVERPRYVIVFFQTGKRNTIKADPSLFDNVSIQSIRLSLNGEYFPNERMQLDFSKTDYNEAYFNYTEFHPSYAHSTQKRRLLDFSAFQHHALFVIDCSKQEESIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHI3</accession>
    <name>A0ABM5KHI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509671.1">
        <property type="nucleotide sequence ID" value="XM_050653714.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653714.1">
        <property type="protein sequence ID" value="XP_050509671.1"/>
        <property type="gene ID" value="LOC126886712"/>
    </dbReference>
    <dbReference type="GeneID" id="126886712"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="436" mass="50722" checksum="D4C3220F4A7A9810" modified="2025-10-08" version="1">MADVRDIMELERPSTPEVTRETFLGNDKLKKRASTGPKVSKRPEGMHREVFALLYNDNKDAPPLFSSDTIGNNGYKQTKIKLGMRKPRKWKWMPFTNPGRSDNATFYHWRRPSDEPKEYPFAKFNKVIEVVKYTEQEYNTHLKCDNWTKEETDHLIDLAKRFDLRFIVMADRYDTEKYPKRSVEDLKQRYYKICGILSKLNGEKKIYTYDADHERRRKEQLKKLYERKPEQIEEEQFLLGELKKIEARKKERERKTQDLQKLISQADSQNDTPRRNDKKLPKKKIANPARPSRVDTNHILQAIESAGIKFPDYKNSGVSLRSQRMKLPANVGQKKSKGVEQILQDMGLELNPTPSEEICQHFNELRSDMVLLMEIKGALATCEYELQSLRHQYEALNPGKTLAIPPQLSSNSEVEAKISTSEIIDVVGSPDTPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHN3</accession>
    <name>A0ABM5KHN3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050509722.1">
        <property type="nucleotide sequence ID" value="XM_050653765.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653765.1">
        <property type="protein sequence ID" value="XP_050509722.1"/>
        <property type="gene ID" value="LOC126886748"/>
    </dbReference>
    <dbReference type="GeneID" id="126886748"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="134"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="336" mass="37601" checksum="0660BA2024E66DE8" modified="2025-10-08" version="1">MALKWGVAGAGRISHDFVTAVQTYPKSDHVFTAVAARSKASAEKFAKDHSIPQSYEGYLGLAQDRNVDIVYVGNLNPQHFETTKMMLEHGKHVLCEKPFTMNEKQTRRLYQIAQEKKLFLMEAIWSRFFPATMEMKRLIDSGAIGEVLHASVHFGHQIDHVDRITAMDLGGGAILDLGVYILQFQQYVFRNLKPIKIVINGHVNKFGTDESCGAVITYPEGKMAVVSTSTRLKLPNEGIVVGTKGTLRLPDFWCPDKLIMPDGSVKTYPLPVSSVPFLHHNSAGLCYQAEEARQCIKKGKIECPHIPHAESIELARLMDLFRKEVGVAYPEDSQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI22</accession>
    <name>A0ABM5KI22_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509847.1">
        <property type="nucleotide sequence ID" value="XM_050653890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509848.1">
        <property type="nucleotide sequence ID" value="XM_050653891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509849.1">
        <property type="nucleotide sequence ID" value="XM_050653892.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653890.1">
        <property type="protein sequence ID" value="XP_050509847.1"/>
        <property type="gene ID" value="LOC126886824"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653891.1">
        <property type="protein sequence ID" value="XP_050509848.1"/>
        <property type="gene ID" value="LOC126886824"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653892.1">
        <property type="protein sequence ID" value="XP_050509849.1"/>
        <property type="gene ID" value="LOC126886824"/>
    </dbReference>
    <dbReference type="GeneID" id="126886824"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="786"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1489"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1581"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1661"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1763"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1801"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="863"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1497"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1584"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1596"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1694"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1715"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1763"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1820"/>
            <end position="1829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1843" mass="210783" checksum="B27A173FBB73EC79" modified="2025-10-08" version="1">MSWMKRRGPSTPSPAPAPAVPMYNPNQHSATQETQWQNQPVQNNWYQGQQHAQYQPVPKQENTNPPQQNYWQQQQHNPLSYNQNSQYNQHQYQNQQHTGYVQNNSGYEQQHYSNVQYSQLNNQNNVYGTGTQSGQQQTGEDPWNWSWGDEDNSNVQPTPQATITPNQTGGQTDGSFGNLDTWNWPAQEAKNPVKNEEPTDTHELFPKIGLVAKISPKSDTDTDISKLHPLQDHLTVTGKRSKLETPQWSTESQMSQESSDDILHTSESDKSHMMSRSSTISHSPISGHDLIAQNLDEPPVKNDVYETKEMMSNVRLNPTPPSPKTLQGPPPLPTSSIADDPRNPYKRTTTLSHTSASRFRASNITPPDTRQNVYQPTFHNQQINLENADSSEPIAMSDPDHSQSVQKIKLGHKLDNNEAPMNDRNQYLETGQLSEVNYNDRMNEQTSEREDQQIYDQEGLENITDAYPPPGLRRMVPGQLEQAEPTSNVPNFTDEPPPGLSRMVLGQTESAAPTTLGTVAQNVDLLSQFDTSGPPEGLRRMIPGESSSPESSLRIQQQNREDNESEPEFSQLTQHTSQPRSATIGADTPPAVNNPIASQPSANNISRARLENGTNVPTRSSSVEPDNKRRDSIEGEPQEQEISNITNSVRNMTVGENLTDGHVSNNSLPDPVPRRQSRQESSDSDRESRKPPRGPSRDKKSAERTTKRDRDRERDRDREKDRDKSRRDRERYSPDNYRDKKYERRRYRDRRYEDDTDYYSDKEKEKGFDEWDRDYDRKYNSLRKDKEKERRRMERDPRDYNRRDYYYGSRYGDDYENEQRSRPSSRSDSLHESYRARDKDQDRDRRNRDREREKYRSRRDPRDAYNYQGYSYDPFNPYYQQYQYYENLRRTNPQAYAEWYRKYYQQATSHSASYGGEDRASVHSGRSSANEELAKDRYTRQSFYSQMSSTQIGGYYRDTHSHTHSQYGHDASSYSRPFDQTDSLLALDDTTAASQRLTPAKFTMAHIKASIASGKLLRILPHYPIDGQPAVVEICSTSSFLANDEEFQELSQFPGPLVKGVTHKKTIIEYCENKIRNAIAGQKIDDVESYILMWELLILLIRQNGMVVGADIAELLLQNRREIPPPRAASVISSLSSNNGDINHSSEASNHIVSENTGSLLSVLKEEEITNKFREFLLYGSGKEALEWAMKHSLWGHALFLASKLDKRTYANVMMRFANGLTMNDPLQTLYQLLSGKMPAAVTCVSDDKWGDWRPHLAMILSNSSQRPELNCKAITTLGDTLRNRGSLYAAQFCYLMAEVGFGKYDNPDTRLVLLGADHSKPYPTFATNEAIHMTEIYEYACGLNDSAFVLPHFQVYKYLIATKLVDRGLVEKSLAYLENIASVIVANPSLVEISFVDNVYNLADRLKYYDLVGEVEDESQFGGMLETNRPDNSWLKDLKNVQNDFHAGVISHQSMQNLQPYTTTSYEADINQQQQNYENSMPELQQYEYQSNSAPQQSWQQEQHQQVPEYQDNQLQQQTQQADFSQNQYQDQQNYWSNQQQWNNQPNQYIQEPVDQQNMYGLNNQINEQKEVEKDIPEEPLQPQISLPNQLNAYEDEKPEKQEERKPVAKPKPAPAEPEKTQSTGWFGGIFSKLALKPKNQMKLPDDKNPKIVWDQDKKRWINVDEDPNDPANEFKPPPKLSELMPKLPPAQQAHSTPTSANTSLPSFDPNRTLVEQNGGVPNTNSGIEDAGPQRPSQQGNMFKLQKGRNLKNSYIDVFNQGNKQQANSGPASLPAPNQLPSAAPQMNFFVPQPIADPNAPIDFLTPGGVPHIGDPQMSRWSSSSSLSKEVQFYMQQKPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJE3</accession>
    <name>A0ABM5KJE3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510223.1">
        <property type="nucleotide sequence ID" value="XM_050654266.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654266.1">
        <property type="protein sequence ID" value="XP_050510223.1"/>
        <property type="gene ID" value="LOC114332431"/>
    </dbReference>
    <dbReference type="GeneID" id="114332431"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="550" mass="64649" checksum="F83C2ECDCE0899DC" modified="2025-10-08" version="1">MRRVTCGCGYMWVTCYLHEEFLFVFVFYYCNNCNIVSPPRRPVTFFCLCVHCSVYLLILVSAMECNIEIKEDSVECGHSQSRIIENQLFTSTDLEDLKKGPATRAVKAEIKEEFVPYPRYIEEQVSTSLDLRDLKNEPDEDNSDRAVKVEIKEDFVEGDPRYIDSQLSTSLDLEDLKDEDTSGFLEEKNISETTESILVHSCDKEQPTGQPVEEKPNCKICFKQFSHRSSLKRHMIVHKGQRPLNNHTRGHTDEKHYKCEICLRRFIYSINLKKHMTSHTGQKPSLTNYKCGICFKQFFQKKYLKNHLKRHTEEQQHYKCEICFKEFTYKTSLNRHKKVHIGEKPYKCEICFMRFIYRSLLVTHTQVHTGEKPYKCEICFKQFSHGGHLKRHLLVHTRERLHKCKICFKQVKGGLKAHMSLHTGEKPFKCKICFKRFTHLNSLKGHMRLHGHAEEKPHKCEICFKQFGGAFNLKVHLRVHTGEKPHKCEICFKQFYKTSNLKVHLRVHTGEKPHKCEICFKQFSQAGSLKTHLRVHTGEKPHKSLVYHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJM8</accession>
    <name>A0ABM5KJM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050510410.1">
        <property type="nucleotide sequence ID" value="XM_050654453.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654453.1">
        <property type="protein sequence ID" value="XP_050510410.1"/>
        <property type="gene ID" value="LOC126887111"/>
    </dbReference>
    <dbReference type="GeneID" id="126887111"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="837"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="960" mass="113025" checksum="4BB64B7F761DB368" modified="2025-10-08" version="1">MELEHLHELKHELDIYEDQLDKVDIADLFKHDSEETMYFEDNHVQIESYQTHLGQPTDNLKDVPNHTDYQAILTDNVKIDHNLVAEGTEKGFPSSVFQKDDIDSDMLQHPTGKSLQHHNKSANISTKMFVENNQLIQNMDSAEKQIIAKNNNRNINLSFEKSFSCNVCSIKFTLKSSLRKHSLTHAEETPFECDICHKRFSQNSQCLAHRQTHTKEEPFRCSICFKYFKGESVLNGHMKLHTGSSILTESDRSNQQDDLHDEDNSLESIMSENSSNISTDNDELTHSILNIEENHMQQTKFDNHLKEKPNQRTFVHSKETDKLFQCKICYKRFSVITNLTRHIFRHADLARFKNRIQKRTAEQQLRCHICFVQFTFKDSLRNHLLRHVGEKPFECNICRKLFFQNNNCIVHRRTHINGKSLEKKSLDIYSNMPTEIDQSMENVPLNAEKESLQNVTSDHLSNVSKVDSFQCKFCFKQFSLQANLKRHMLTHLGIKPFKCVICLKTFSSQIALTEHERIHSGEKPYKCELCEKEFISKYIFKKHMRFHTGEKLIKCDYCPQQFTNNTSLKRHIVSHTRERPFQCIICFKKYSNKGNLDRHMRCHTGENRQFKCTICLKTFSSQITLTDHERIHSGQKPYKCELCQREFRSTNCFNKHMRLHTDEKLIKCDYCPRQFIDNTSLQLHILSHTGERPFQCVVCFKKFSRKYSLNKHNMRSHTGENPRFKCIICLKTFSSQITLTDHERIHSGKKPYKCELCQKEFRSKNPFNKHVRLHTGENLIKCDYCPQQFTNNTSLKRHVVSHTRERPFQCIICFKKYSNKGNLDRHMRCHTGENRQFKCTICLKTFSSQITLTDHERIHSRQKPYKCELCQREFRSTNCFNKHMRLHTDEKLIKCDYCPKQFTANSEFQKHVVSHTGAGPFQCVVCFKKFGTKSNLDEHRRFQCCISHYAKYAKASGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KK62</accession>
    <name>A0ABM5KK62_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510513.1">
        <property type="nucleotide sequence ID" value="XM_050654556.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654556.1">
        <property type="protein sequence ID" value="XP_050510513.1"/>
        <property type="gene ID" value="LOC126887171"/>
    </dbReference>
    <dbReference type="GeneID" id="126887171"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046214480" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="103" mass="12318" checksum="3FA4907916BE1253" modified="2025-10-08" version="1">MEALYLFLLTMLVTLSTHASPVPDDSRYLYYADRAPANLNRLFLVRRQAEPDIGYSDESLDDSPRRHYYRPYVRIRRVYRTHYQPRHPLSNYADSYDRFPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQY8</accession>
    <name>A0ABM5KQY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512599.1">
        <property type="nucleotide sequence ID" value="XM_050656642.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656642.1">
        <property type="protein sequence ID" value="XP_050512599.1"/>
        <property type="gene ID" value="LOC126888403"/>
    </dbReference>
    <dbReference type="GeneID" id="126888403"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF419">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="496"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1100" mass="129530" checksum="37E5CB4F6040A21A" modified="2025-10-08" version="1">MSCSEEVILEIEGTPVKCKRDVLISNSDYFKAMLEGNFIEKDQKTISIKDVDLKAVNIILTLLGDPRNDTEDEDVLMILHAACMLQFCEIRNMCLDKLNQILSVQNCLKVWIMAEQLELKPLVLKAKRLALTEFMSIIKENDSINDLNLQQLIRYIGSVHLVTDSELTVFQTLMKWWYDHSKDHTSDDFIKLLSCVNYKQLLPDHFREILTYPDLAITEVEDILKCLYNLLNNIPNISCSKKCLKVASVLSQSNDRKIIIDSVPCLLVRNSSNDVPNKKRLVENNEIGVDKSKLRVVYYDRSKLHVIYYDRKLGVFRRFVNISEEVEKQFRRFILKGYKEYIFLFGGEHLVHVPGDVERKYSLLIYDSIKEIWITKTRMPFPFPRTHFEACIVGSKVFISGSIGKNRFIPANIFYYDYKTNEWSEQYTCPQRILERSYKCCNYLDKFLVFSLYKKCACVFEDSGFTIWPVVFPPTLHHDTKKIWVECGNFSLFAYKDRLYLKEIEGTPVKCKKDVLISNSDYFKAMLEGNFIEKDQETICIKDVDLKAINIILTLLWDPTIYIEDEDVLMVLHAACMLQFCEIRNMCLDKLIQILCVQNCLKIWIITEQLDIKPLFLKAKRLALAEFMMIKETDSINDLNLEQLIRYIGSLHLVTDSELTVFQTLMKWWYDHSKDHTSDDFIKLLSCVNYKQLLPDHFREIRTYPDLANTEVEDILKCLYNILNNIPNGSCSEKYVEVATRLSQSNDRKIDSVPCLLVLNSYDDVPNKKRLVENNQTVVDRYKRKIVYKIFVADKSNLHLVYYDRKLDIFRGFINIFKRLEGFRLRGYKEYIFLFGGEYVLGKGEWNYTFWVYDSIKDMWRTKSRMPFPRRHFETCIVGSKVFVSGGIGQFRIIQSNVFWYDYKTDEWSKQYQFPQNVFGRSYKCCNYLDKFLIFSVNKKCAYFFDENSGWTILPLVFPPTLDHDIKNMQTESGKFSLFAYKDRLYVKGKEILEMKMVRDGLEVISVKTISTVKYDELEETVCDNILYTLYKQHTLNGYIYSFEKYNLDTHKIEIIFKKLKEEDSLYVEGELLNLDQSLNIFSFSHHSLFDENQLVNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KR53</accession>
    <name>A0ABM5KR53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512666.1">
        <property type="nucleotide sequence ID" value="XM_050656709.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656709.1">
        <property type="protein sequence ID" value="XP_050512666.1"/>
        <property type="gene ID" value="LOC126888443"/>
    </dbReference>
    <dbReference type="GeneID" id="126888443"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF55">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="132"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="411" mass="47289" checksum="D41C181A2C53CCE1" modified="2025-10-08" version="1">MEGERIKDLNNLLKPALGENVEIVDKTITNLTQPGDNYFSDMLKLQVTTRNKDTNATNTEHFVAKCCIADADMAAQSSSLFKPEIAFYKEIVPTMQKFLKEHGQKEVEIFPKLIAARYNLDGKEEPDGDAVLVLENLQVAGFGNQDRHKGFDLEGAKLLVTDLAVFHAVPLAIKLKQPDLFQKVFVDNCPKNKPKENGPDHRGIPKMPRATLKQILSQDHICRKHVDKLDDLIDADEDNFSKGNLFNKFDIKETVFSGLVHKDMWVNNTMQKKDKDGRIVKNNFVDFQMYGIQDVTTDLIFFLLSSVDIVTLEEHFEYLLQLYHEHVIKTLESLKCDVASFKYVDFINNLKENTIGEFFHILLMNNLIIYIKKGEKTDFDILKNLTVDSMHPIARRKFVFLFKMLVQKEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRA8</accession>
    <name>A0ABM5KRA8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512724.1">
        <property type="nucleotide sequence ID" value="XM_050656767.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512725.1">
        <property type="nucleotide sequence ID" value="XM_050656768.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512726.1">
        <property type="nucleotide sequence ID" value="XM_050656769.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656767.1">
        <property type="protein sequence ID" value="XP_050512724.1"/>
        <property type="gene ID" value="LOC126888454"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656768.1">
        <property type="protein sequence ID" value="XP_050512725.1"/>
        <property type="gene ID" value="LOC126888454"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656769.1">
        <property type="protein sequence ID" value="XP_050512726.1"/>
        <property type="gene ID" value="LOC126888454"/>
    </dbReference>
    <dbReference type="GeneID" id="126888454"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="710" mass="78963" checksum="C3F7746DA02F02F5" modified="2025-10-08" version="1">MELSSGSPNSQDYLKFTKGRRSSSSSYSSYLSEGDIDTIDINSIHFDNDECWLCASNVEDPIVDLDQWLHKDLDSSYSPLANINSHISLHKNVDSRTFTRPKKRFTRPSIERYNEEMYGGSSETITLPSSPRSFVIEENPEFNATLSENSVNFDLSQPSSSYYFEKIVADCGDMDSFQNMSPPSLVNSMCSSTFANLMESSFIKNDPILREIRDTDYSEMVLLQDCEAPMFQSFTESCSSINSDTPENFLKKVSFNGTFKRNTSKDEINKLRSLNATFDACESEKELDKTLKKDSENSSPRNDHTWVNPNGTYRRTPKHNGTFKKSDLKKSHNILNTTFDTDPSPKNNINTTHTLIKDYNGLEDLKKDLSDPIEIHTDLNRLSYCLENEDEKLDATYNDVNRTSNSLKTSTLSGSAGSADSLDRLSSMSSSSRGSNKMLNMADVDAIVEMQERSLQQVMSTPKVATANKRLWENNFISPITAEHTSDSDLSSNDDYKSVRSSVSSKTSLDQYVPKQPKSLGYLHGPAEIKIKTNQKSTYTSAAPKPVPVVRPNPKTNSYSNLRSMNSNLPASYSNIYKMSNPKTQSGNAVSNLKTMGSKLKGSYTSLRPMSSNLPVAPPLISSNTTMTLAKSNSVPHGVDSATRIVEVQPLQREKITIVGDNTFVKPQPVKASGLPRPTGIPRPASRIPAPRSSNVRPNSWSFADSQSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRH0</accession>
    <name>A0ABM5KRH0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050512781.1">
        <property type="nucleotide sequence ID" value="XM_050656824.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656824.1">
        <property type="protein sequence ID" value="XP_050512781.1"/>
        <property type="gene ID" value="LOC114325202"/>
    </dbReference>
    <dbReference type="GeneID" id="114325202"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06624">
        <property type="entry name" value="STKc_ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046872">
        <property type="entry name" value="DRHyd-ASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046873">
        <property type="entry name" value="HisK-N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043969">
        <property type="entry name" value="MAP3K_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025136">
        <property type="entry name" value="MAP3K_TRAF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF394">
        <property type="entry name" value="APOPTOTIC SIGNAL-REGULATING KINASE 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19039">
        <property type="entry name" value="ASK_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20309">
        <property type="entry name" value="DRHyd-ASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20302">
        <property type="entry name" value="HisK-N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13281">
        <property type="entry name" value="MAP3K_TRAF_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="613"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="1220"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="876"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="957"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1131"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1301" mass="148420" checksum="B10990BD7BCEF588" modified="2025-10-08" version="1">MPIPPITTVLETETECRSITDSVGSHSDISGTTVHTGSTMTKSQMDVVCVIDINQNENILQRKKALEEIKQACLQVGANFNHLQFEKLDFGEANVVSSFYNADVVIIDLSFPAQQSTLFYHLGVRESFNMKQNILVYNDIDPDVTLKLKLSCSSYSFISYKLSENSCLTTCPSGRVDEPIDFLHQKLKKLLQDVEVQTKAHMKEKFLSDLKKLKEQKNGEELNEALLLMRKRLDDPNVLSGEVILNMLFCFRDIQEYDAMIHLVEDLRKVPTARKYLNSYIMFLYAFALNRRKKDGDRKNALAVCEESLKSKENHFPDMLCLCGRIYKDMFTESDHKDTKSLDAAIYWYRKGFEVQPNEYAGINLATLLVIKGAEIGKSDELQHIGMVLNNLIGKKGSLASLIDYWDVATFFEISVLFQHYSNATQAAACMFKLKPPNWYLKSTVGNIQLIDRFRKKSEEAVSPEEQIFHFWMEFFLEATKEEQEEAFRFPALILEPSKELMPSYVCINLGADPQTLQVNNLCDRSLRGECKQIHDWEFTANQIRSVSFYKRDERCLFLYVHHNSDDFQIFFPSESCRECFYKLILELTNHQEGLVESEPPRDIKYEYERDEIGKKLLLGKGTYGIVYAARDLNTQVRIAVKEVPEKNLGAVQPLHEEIRLHSQLRHRNIVQYLGSLSEDNYFKIFMEQVPGGSLSALLRSKWGPLKSNEHTMAYYTKQILEGLKYLHDQKIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGLCPSTETFTGTLQYMAPEVIDKGQRGYGAPADIWSLGCTVVEMATGKPPFIELGSPQAAVFKVGYYKAHPEVPEELSERARSFIKRCFEPDPDKRATAAHLLEDPFLGPERRQKTVRLNTEFNRSVSVPAEKKSTRQTGHNSAPNQTPVSPETDQALQEEENWHSVGSHQSRASLLPPIQMPTALTFNSLASTPSLDCESESPNTERRNSSGTLLSPEVDTGTETDGFYLLKKDSQRRTTLAKVLANDGIKICEVWMQKVREKYLGETVLTEKHLLRLMDGLKAYLTEQSMTVVESTVRQLKEELDFDSAAINQLQFAIYLYQESVNEVLRLHPIKPHWMFALDNLVRSCIQAAITVLTPELSEHIANHSSPSTVNSSKSSKTNEGYDVRDSNLQLRNENSRLWQDLLECQRQYQGLLKQLIETHRQEIALRQLCCHRCCCQSRNNNNNDLQEIVEEDQRLANWLEGLGIHESAKRIFVSEGYTLEEVLYHISREDLEKVGLKGSTALRIWRGIEQHRHGNESIICNGVTLDESGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRI1</accession>
    <name>A0ABM5KRI1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512793.1">
        <property type="nucleotide sequence ID" value="XM_050656836.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656836.1">
        <property type="protein sequence ID" value="XP_050512793.1"/>
        <property type="gene ID" value="LOC126888499"/>
    </dbReference>
    <dbReference type="GeneID" id="126888499"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27261" checksum="9C188500B9806743" modified="2025-10-08" version="1">MPYTTVWKIVTNRTQPRKKQGDFSTHKAVNEKDAEVIRRAIYNFYSKNLVPPLSMIYDQLVKDYSITYSPSTLSRFFNHIGFRYKKINKRSSIMDSPRLIKWRNEYLDAISKFRDEGRPIFYLDETWFDTHDTVQKGWTDDSIKCASNYPINRGQRIVILKIGSKNGWLGGESFLLSAKNIKDSKLDYHENMTSSLFKEWFEKKVLPNLPPKSVIVMDNATYHSEQTRKIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSB6</accession>
    <name>A0ABM5KSB6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050513080.1">
        <property type="nucleotide sequence ID" value="XM_050657123.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657123.1">
        <property type="protein sequence ID" value="XP_050513080.1"/>
        <property type="gene ID" value="LOC126888728"/>
    </dbReference>
    <dbReference type="GeneID" id="126888728"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="5">
        <location>
            <begin position="627"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="705" mass="80131" checksum="156ADB9D4E1FBD00" modified="2025-10-08" version="1">MSDSTSKGKSYKKCIKCGADERKATSYKKFIVSDSLANQINQVLNLNSALGDYICKSCYTTFQFLNPKPKEQQDSSQQEQCSQSTQTDSQGSGPITLSQSSSNVSEFVLEEYPKEEEECIELPFPRPISTHKYCFLCGKSTIIVNVPFNARKQVFTSKKIFIPDGNRCCSTHLIKKRFFEDEINNIQVYTHYSSIKKSDVIKLLENLRVDIDKELTDKIGECSLSEERLLIFTGLTWENIIMLRDMMTSLRNTESRNIIQALVVFLFKLRSGNSNNTIAAVLGLERPQQVSDFSASILSSFEKDVLPSRFGIQAANRQHLIDQTAPVAKILYDIRGDQLGLVCDGTYLRHEKSSNNEYQRKSYSGQKKAPLCKPFTICTTNGYIIDILGPYYATDNDAKILESILNDPNGLITLLQEGDKFFLDRGFRDVIQKLSNLQFQALMPALKGKRKQLTSIEAKESRMVTMVRWVVEAVHGVISQKYKLLHNQFDNKMIPNAALYCKIAGFLINTFGKRYVSEVSSKNEIIAQINKIKSLENTLLQECEENRWGRRKTLFQPLQSNDVLDFPEMTEQDLITFFTGTYQLKQSISYLAELITEDNKVDLQFLKETADIIKIQVRSRHIKAKTYNCYIHYQPHSIGTSGIKRHYCDCANGARTIGCCSHVAAIIYYLSNARYLAKIVNPAKILTNIFDSNVIPVINEDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXF5</accession>
    <name>A0ABM5KXF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514862.1">
        <property type="nucleotide sequence ID" value="XM_050658905.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658905.1">
        <property type="protein sequence ID" value="XP_050514862.1"/>
        <property type="gene ID" value="LOC126890075"/>
    </dbReference>
    <dbReference type="GeneID" id="126890075"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19578">
        <property type="entry name" value="serpinK_insect_SRPN2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF357">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045947316" description="Serpin domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="40"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="421" mass="47894" checksum="6272416B126B1D80" modified="2025-10-08" version="1">MLLGFFILGTCLLHVGHCNSSPTTNTVEDIDVYYPNINWSNIFDWRILKEYSPTYKNLLVSPISLRIILALLYQGSSGLTKREFESVMHFTDQQSAREEFRNILNKLQVAESPEYTLNLGTRVFLDIPVAPQQKFASIAKDFFKTELVLTNFTNKEEAGNTINSWAEQQTNGRIHKLIDPADLADALMVIANAVYFKGTWKYQFPFQTVDKFYVPDGNNFFSIQARFMAVEDKFYFHESPLLDAKILRLPYKGGRYSMFILLPNSKGGLPSLIKQININNLKSLLYLMDQRLVNVTIPKFRFDFQARFSRTLQEFGLLQMFQNTASFPGIARGDSTILRKLVVSDIVQKSGIEVNEYGSVVYGASAITIGNKFGEQTQTFHATHPFMFYIEEELSGTVLFVGKVENPLESDPLPLAPKPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY93</accession>
    <name>A0ABM5KY93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrokinin-1 receptor-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515163.1">
        <property type="nucleotide sequence ID" value="XM_050659206.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659206.1">
        <property type="protein sequence ID" value="XP_050515163.1"/>
        <property type="gene ID" value="LOC114324561"/>
    </dbReference>
    <dbReference type="GeneID" id="114324561"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29862" checksum="93E259C8888CDD18" modified="2025-10-08" version="1">MIRAFQILTYVSGIFYYLSTTVNPLLYHIMSNKFREAFKKTYKQLCRKSRKVPGGRCYSSLSAPHQSNSDSYSGGGWGGTGSGSLRYLEDSVAARLHDHRRPLVVSFRRQKRAPMQDVIEVDADLAASRSSRGLSEICMARSSGSPNVIRRSDMKGFSYSPSAKLKNSFSFSSPLIMERLIIERSRSFAKDKQTPGNDLDGVLGSELRYRSETNNHPEVNQFGFDDRYRREVPKRSNCSFVEVHTLRPTHICPLSSKNKALEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYD8</accession>
    <name>A0ABM5KYD8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515197.1">
        <property type="nucleotide sequence ID" value="XM_050659240.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659240.1">
        <property type="protein sequence ID" value="XP_050515197.1"/>
        <property type="gene ID" value="LOC126890362"/>
    </dbReference>
    <dbReference type="GeneID" id="126890362"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="137" mass="16078" checksum="768BA64B3179E5EE" modified="2025-10-08" version="1">MANVETTANKLGIELTCPRVAARQVHRPNHSTQTINEYYRKSIFLPYLDSLVQSLKDRFSDRNKPSFEIFNLHPKIMKDLSKEDFEKSINNINSTYCELLDNFKEQSILWFDLWKNTEIDAKALEKLNLIEVLEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1N2</accession>
    <name>A0ABM5L1N2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516344.1">
        <property type="nucleotide sequence ID" value="XM_050660387.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660387.1">
        <property type="protein sequence ID" value="XP_050516344.1"/>
        <property type="gene ID" value="LOC126891205"/>
    </dbReference>
    <dbReference type="GeneID" id="126891205"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="48252" checksum="73D565A45FB9987F" modified="2025-10-08" version="1">MPKRHYIRRQVHQQEPHIFDLYQKPRFDDTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFAIHDTLLEIKGSIKKAGNGTVSLAPNAGSFLFDTCTYIQSSHDMEIVRDPGVVSTISSLLCYTPEDSRFLSTAGWNYPDYPHLTGDTFSLLIPIKHIFNIFNDYTKLTYGRQVFRFVRARNDRDCIVVQEPTGSTTVTTVSLTIASMELKVKHVFPNDDVKIELMTPIKNNTPITIPFRKWELNELPSLTAGSRREIWSVKTTSAVERPRYVIVAFQTSKRDDIHADPTLFDHIRMSSVRVVINGDYWPNERMQLDFAKNDYAIAHYNYTEFLSSYARSLTKHPILDYSAFKRYALFVFDCSKQDDTSFRSGTVDVKLEIEADEGFPAGTRAYCLIVHDSLLEYFPLTEVVKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L243</accession>
    <name>A0ABM5L243_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516507.1">
        <property type="nucleotide sequence ID" value="XM_050660550.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660550.1">
        <property type="protein sequence ID" value="XP_050516507.1"/>
        <property type="gene ID" value="LOC126891373"/>
    </dbReference>
    <dbReference type="GeneID" id="126891373"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="248" mass="27770" checksum="EF1954A8A1BCAA58" modified="2025-10-08" version="1">MLRTMLQIKENVDIKYPKVIAFLKRQNQGYKANKAKTFSREEVNKFLLDAPDDNYLLMKILLIFGISGACRRDELVKMVTKDVEDKGSILIVNIPNTKTNMQRTFVINASSGNGPNYIEIYGKYISLRRKIDRSRLFVCYRAGKCSKQLVGKNSISKIPTKIAVFLKLPYATNYTGHSFRRTSASLLANSGGDILALKQHGGWKSTNIAEGYIEQSLAKKQKISEQIVGVTEVEEADCNQPSTSTFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L273</accession>
    <name>A0ABM5L273_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516530.1">
        <property type="nucleotide sequence ID" value="XM_050660573.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660573.1">
        <property type="protein sequence ID" value="XP_050516530.1"/>
        <property type="gene ID" value="LOC126891398"/>
    </dbReference>
    <dbReference type="GeneID" id="126891398"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="307" mass="36284" checksum="A5C995CA874327EA" modified="2025-10-08" version="1">MEILHVLGQPFSDTTIEAYQYHTYQPYTSNLNYNDEIRINIQDLDAYTLPCNSYIYIEGKMLTDDNKVPTKFQFINNGISYLFRELRYELNGVTIDSVRNIGLISTLKNYLSLNENQSKLLQNAGWFPKEDKLKIDTHGNFNVCIQLKIWSGFFEDFQKIIINMRQELVLIREKDDIDAIIATDETEKPKIEINKLYWNVPHILPNISEQLRLNKIVRSNTELPIKFRSWELIEYTTLNNSTRHTWPVKTTTKLESPRHIVVAFHDGRKGKMLKDMSKFDHCNLTNIRMFLNSERYPYQDLNRLTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3W8</accession>
    <name>A0ABM5L3W8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Parathyroid hormone/parathyroid hormone-related peptide receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517124.1">
        <property type="nucleotide sequence ID" value="XM_050661167.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517125.1">
        <property type="nucleotide sequence ID" value="XM_050661168.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517127.1">
        <property type="nucleotide sequence ID" value="XM_050661170.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517128.1">
        <property type="nucleotide sequence ID" value="XM_050661171.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661167.1">
        <property type="protein sequence ID" value="XP_050517124.1"/>
        <property type="gene ID" value="LOC114332250"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661168.1">
        <property type="protein sequence ID" value="XP_050517125.1"/>
        <property type="gene ID" value="LOC114332250"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661170.1">
        <property type="protein sequence ID" value="XP_050517127.1"/>
        <property type="gene ID" value="LOC114332250"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661171.1">
        <property type="protein sequence ID" value="XP_050517128.1"/>
        <property type="gene ID" value="LOC114332250"/>
    </dbReference>
    <dbReference type="GeneID" id="114332250"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15273">
        <property type="entry name" value="7tmB1_NPR_B7_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="141"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="155"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="62025" checksum="CAA72562E4F23C92" modified="2025-10-08" version="1">MPNRHIQIILEKQDRELYLAEQNCTILYGPDVKNKHQGAFYNRTSQNLMCPPFWDSIICWPYTPAGEKAVIPCPSYFAGFREDFNATRTCTENGTWYVNSSTHEPWGDYTACSEGRIATIFTNITSKSDLWKRYETLVPILKIISQTGYAVSLLSLIAAFIIMLSIKKLHCARNILHMNLFASFIFRALFHILKEILFVEGVGLQIDFSEKNGDLYFKTDIEQNNYQCKLLTSLVQFFTTANYSWILMEGLYLNNLIWRALFVDSSRNLVYYICLGWGLPIFVIIPWIIARIFLDDTMCWTTNDNVKAYLIIVIPTIIAVLINFALFIIISIVLYTKLRSPICEDTKRYQKWARSTLVLVPLFGVHYAVLLIFYFTGKTDIWLICDSLFGSFQGLFVAILYCFMNGEVKTELKPHIYNFLSYLATHPILGICFPCRAKFLRSAVGRRSVCTTLSYSSIYVNGVGHRNSKSKFIEKGRHPNQEKNHCCNGKHPSTKNGVQVGIKHVGDGQAETSLCNDQRSEKCRMQSCETDEEICMLTKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5V4</accession>
    <name>A0ABM5L5V4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517820.1">
        <property type="nucleotide sequence ID" value="XM_050661863.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661863.1">
        <property type="protein sequence ID" value="XP_050517820.1"/>
        <property type="gene ID" value="LOC126892343"/>
    </dbReference>
    <dbReference type="GeneID" id="126892343"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="739" mass="86449" checksum="CC436E22BF28AC78" modified="2025-10-08" version="1">MMHWNENIKDSGNQKKLTYIKDEGDSLKKYDNEQVKSELDLDEYGFESSSGQESVLDEYSDDIKIENHVVEDVSNEIKLEIKKELEEYSIGVPHDITMEVTSTKPVNAPKAYLKTYTGERLYKCKICCKLFIVKSSLKDHMRVHTGEKPYKCKICSKQFSHISNLNKHMKIHIGEKPYKCEICIKQFSYLSSLNDHMTVHTGEKPYKCKICSKQFGHISNLNKHMKIHIGEKPYKCEICIKQFSYLSSLNEHMRVHTGEKPYKCEICSKQFSRKSGLDKHMKIHTGEKPYKCDICSKLFTENGTLKEHMRIHTGERLYECEICSKPFTRLSSLKLHMRVHTGEKPYKCEICSKQFSELSNLNTHMKIHTGERPYKCEICSKLFYIKSSLKVHMRVHSGERPYKCEICSKQFSRKSGLDKHMKIHAGEKPYKCKICCKQFSHISNLNTHMKIHIGEKRYKCEICSKQFSYLSSLNEHMRVHTGEKPYKCEICSKQFSRKSGLDKHMKIHTGEKPYKCDICSKLFTENGTLKEHMRIHTGERLYECEICSKPFTRLSSLKVHMRVHTGEKPYKCEICSKQFSDLSHLNTHMKMHTGERPYKCEICSKQFYIRSSLKVHMRGHSGEKPYKCEICSKQFTIKGSLSEHMRVHTGEKPYNCEICSEQFSYLRSLKEHIMTVHTGEKPYKCENCNKQFSLNRTLNSHMLVHSGKKPYKCEICSQQFSRKSNLNRHMLVHSGKRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8Y5</accession>
    <name>A0ABM5L8Y5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 3-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the leprecan family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.7" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050518903.1">
        <property type="nucleotide sequence ID" value="XM_050662946.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662946.1">
        <property type="protein sequence ID" value="XP_050518903.1"/>
        <property type="gene ID" value="LOC126893009"/>
    </dbReference>
    <dbReference type="GeneID" id="126893009"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039575">
        <property type="entry name" value="P3H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14049">
        <property type="entry name" value="LEPRECAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14049:SF9">
        <property type="entry name" value="PROCOLLAGEN-PROLINE 3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046885191" description="procollagen-proline 3-dioxygenase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="498"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="656" mass="76419" checksum="DEAA60E3C34358C0" modified="2025-10-08" version="1">MLINTCAITVFILNVFLLTHVRTNETNDTQTCVQLYEKGLEAYLENRWEGCVVNFEKALEKYRKYRKKVQNCRLKCKSDAEYSEPLYPVDIENLLFFERAIKQTLCIIECQNGSPEILENHNVNMESGNLFEDQRPYEYLHICYFQTKQLEKAASAAFTFLVAHPDNKVMSTNLKHYLDHNVEKKDIVNYEAKDYVYLYAHGADAYEKKEWQFVVFNMEESLVHYLQAEEECRAQCEGPFDHGWYPDFIPSISNHFTVALRCKQKCRKKLSSLNGEIHDDLLPSHYHYLQYAYYKLGNLKAACQAVASYLLFYPDDETMLDNMRYYSKQPKVDITYFQPRREATQYMQRQIYETRILKFVHNEFKNKLVTATTEGVPSQTDSTTSPSNSSEMKLKSGVTMNESDLKGAKRVVIDGMTTPKECKSLMEIAKYYAVIGDGYEGKSPHTKLEKFEGITFNRALFLSYYKMLNLKHLHTFFEVTEKAKELIKVHFKLKGELYFSYTQLVCRSARPDSPTNRTDFSHKIHADNCIIMENMTCFRTYPAFTWRDYSAILYLNDDFKGGEFVFSADAVGKKIQSKIRPKCGRLVAFSSGPENLHGVKAVKRGTRCAIGMWFTLNPDYVEKHRDFAKTVVDNNSQFEMDWLVNLDYPKPYVPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYP7</accession>
    <name>A0A6P7EYP7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114324462</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128121.1">
        <property type="nucleotide sequence ID" value="XM_028272320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272320.2">
        <property type="protein sequence ID" value="XP_028128121.1"/>
        <property type="gene ID" value="LOC114324462"/>
    </dbReference>
    <dbReference type="GeneID" id="114324462"/>
    <dbReference type="KEGG" id="dvv:114324462"/>
    <dbReference type="InParanoid" id="A0A6P7EYP7"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF60">
        <property type="entry name" value="3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028128121.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58052" checksum="40256696162F83B2" modified="2020-12-02" version="1">MDVESFREFGKASVDYIADYIENIRKKKVLPSVEPGYLQNEIPELAPLSGEPWQNILPDVDRVILPGLTHWHSPHFHAYFPTANSFPGVVGELFLSGLGSISTDWVRIQQSNPACVELEVRMMDWLAKMLGLPEHFLNESEGPGGGVIQNAASESTLVGLLSGKQRTVKHILDKNPNLTPEDVKGKLIAYTSKESNSSVEKASLLASVPMRLLPTDSDCRLRGDTLQEAIQKDKAEGLIPCCVVASLGTTGTCAFDDLEEIGQICQKENIWLHVDAAYAGAALVCPEYRYLLNGIDHVDSFNFNPHKWFLTNSDCSAMWFKNTKDAEAAFKLKAAIPSDPIFEPELEHWQIPSSRRFRALKLWFVMRIYGVQGIQKHIRHQVSLAKYLEDLVTSDKRFELLISSLGVVGFRLNGDDSATQKLLDKITERKNLYIMPYYYQNKLMVRFVVCSRLTEKEDIDFAWKEITAIVAAMFNKKSRKNNRKKKDIETAILTKVATTTFPTDFNDKLNVGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2T0</accession>
    <name>A0A6P7F2T0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114325996</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129959.1">
        <property type="nucleotide sequence ID" value="XM_028274158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2T0"/>
    <dbReference type="FunCoup" id="A0A6P7F2T0">
        <property type="interactions" value="1437"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274158.2">
        <property type="protein sequence ID" value="XP_028129959.1"/>
        <property type="gene ID" value="LOC114325996"/>
    </dbReference>
    <dbReference type="GeneID" id="114325996"/>
    <dbReference type="KEGG" id="dvv:114325996"/>
    <dbReference type="CTD" id="41845"/>
    <dbReference type="InParanoid" id="A0A6P7F2T0"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.20:FF:000002">
        <property type="entry name" value="ATP synthase subunit O, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028129959.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22561" checksum="B55C2D7944539B50" modified="2020-12-02" version="1">MASQNLCMAVRNFSTSNAASQLVKAPLQIFGIEGRYASALYSAASKQKSLEGVEKDLLKLQAALKTDAKLRGFVDNPTIKRSLKSEALKAVAQKISLKPESANLLALLADNGRLNKLETVINAFKQIMAAHRGEVSCEVTTARDLDADQKQKLMGVLKSFVKSNQSIQLATKVDPSIIGGMIVSIGDRYVDMSVASKIKKYTEVISATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3A4</accession>
    <name>A0A6P7F3A4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin-protein ligase E3A</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">HECT-type ubiquitin transferase E3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Oncogenic protein-associated protein E6-AP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114325903</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028129851.1">
        <property type="nucleotide sequence ID" value="XM_028274050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3A4"/>
    <dbReference type="FunCoup" id="A0A6P7F3A4">
        <property type="interactions" value="2046"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274050.2">
        <property type="protein sequence ID" value="XP_028129851.1"/>
        <property type="gene ID" value="LOC114325903"/>
    </dbReference>
    <dbReference type="GeneID" id="114325903"/>
    <dbReference type="KEGG" id="dvv:114325903"/>
    <dbReference type="CTD" id="7337"/>
    <dbReference type="InParanoid" id="A0A6P7F3A4"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030518">
        <property type="term" value="P:nuclear receptor-mediated steroid hormone signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000008">
        <property type="entry name" value="Putative ubiquitin-protein ligase E3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="24" id="KW-0436">Ligase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="21">
        <location>
            <begin position="552"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="197"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028129851.1"/>
        </source>
    </evidence>
    <sequence length="881" mass="99329" checksum="29C595F4E06F217C" modified="2020-12-02" version="1">MNSSDKITDPDEASRNNPEASSSNVNNEKTSTDNKDEVMKRAAAKKLIERYFYQLTDGCGNPHCDNRYCASSGEMNPLTPDQAAAQAIQLFSQDARLCERHPNKIARKKENIIINKTETSNDVNFKSNLPTNDIESQSNYSNSKDSVKSNSAPVPTYLTEQALYDIIDECEGNNSYSPLIRTLGEIFSSIENLSKSFPQEASTPTKSPADLENADIKTLNKEEVRSLEGEKDKDEDSCAESSQNSLAPVDIPSVRRAFSALFKLKTSIFENALVNALVTLAGNLQMDLPTRKDKGNHEDIVNVLLIVFEIPALGSGDLLETALPAICRAAQRLPIEVQASLARQWSGVARTSIKSILENLQQLITLRVIMTPFQRDFFVQDENVITSATKLMKIVYYANILGGVLESPALRSPSLSDFSEGINIKPKNTLPSDPLAEELGIHVLDCRTPYIPFTEFYNEPLSDAVEMDRDFANYKSDTGKFSFMHYPFILTPATKTMGLYFDNRIRMYSERRISFLQAFTGLPSQPFLKLKVRRDHIIDDALVELEMISMDNPSDLKKQLVVEFEGEQGIDEGGVSKEFFQLVIEEIFNPDYAMFAIQPESQTVWFNPTSFESDAQFTLIGIVLGLAIYNNVILAVNFPMVLYRKLMGKRGSFEDLQDWNPVVYNSLKQLLEYDESNVEEVFMQTFSISYQDVFGCTINYDLKENGEKISVTQENKYEFVDLYANFLLNKSVEKQFSAFYKGFQMVVDESPLELLFRPEEIELLICGSKNFDFDELENSTEYDGGYTNESQIIKDFWSVVHALSLEDKRKLLQFTTGSDRVPIGGLSRLKLVVAKNGPDSDRLPTAHTCFNVLLLPEYSSKDKLKDRLVKAINYSKGFGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8D0</accession>
    <name>A0A6P7F8D0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 256 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114325791</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129720.1">
        <property type="nucleotide sequence ID" value="XM_028273919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8D0"/>
    <dbReference type="FunCoup" id="A0A6P7F8D0">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273919.2">
        <property type="protein sequence ID" value="XP_028129720.1"/>
        <property type="gene ID" value="LOC114325791"/>
    </dbReference>
    <dbReference type="GeneID" id="114325791"/>
    <dbReference type="KEGG" id="dvv:114325791"/>
    <dbReference type="InParanoid" id="A0A6P7F8D0"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028129720.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="18573" checksum="0B81AC1108E5C3F1" modified="2020-12-02" version="1">MGFNDMLNYIVYDNPISKSTMSFLSGKNFSTASTPPSVTIITEKTPLWKLAAEHGPFIKIAGVMGASAVALSAYGAHRSYPKDQADELRKIFETANRIHFIHSVAIFGVPMCRYPMVVGGLMVTGTALFSVTLYYHAFTGDKKLSGLAPIGGTLLILGWLSMVIWMNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FD67</accession>
    <name>A0A6P7FD67_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114327015</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114327015</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131310.1">
        <property type="nucleotide sequence ID" value="XM_028275509.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519009.1">
        <property type="nucleotide sequence ID" value="XM_050663052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FD67"/>
    <dbReference type="FunCoup" id="A0A6P7FD67">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275509.2">
        <property type="protein sequence ID" value="XP_028131310.1"/>
        <property type="gene ID" value="LOC114327015"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663052.1">
        <property type="protein sequence ID" value="XP_050519009.1"/>
        <property type="gene ID" value="LOC114327015"/>
    </dbReference>
    <dbReference type="GeneID" id="114327015"/>
    <dbReference type="KEGG" id="dvv:114327015"/>
    <dbReference type="InParanoid" id="A0A6P7FD67"/>
    <dbReference type="OrthoDB" id="10056177at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="28"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028131310.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="87402" checksum="DAAD551D5957809A" modified="2020-12-02" version="1">MGEETSTSVEVNTDYTPPKFFRINRSLLLLKSTLFFLHGATSSLVPYLTIHMQSIGLSMEQIAIIYLCLPFTTFLAPPATGYLVDKFGKYKPVVIGCFILTAILHHSLLFMPHQETPGTVPSGYIIRHPKKMYVEVWWSPCPSRECPDDEELDLVLDFCMDHCLLKEAKQAKNKKLIKANPPKRPCDDEDPGDKDDLNFHIKKKQRNDTATAFTLDMHPNLGDPVEQFGIEIEDEDDEDVTDFKKRFRLGMLKRHGVDINELETKDLRCGGIVLEANGTTRSLLRNYTDDCILQKCQFRSGGPEVCPPDYKEAEPMVFWIYGGLRFLATMMQLAATTIMDPVALSMIEKHGGDFGKERLFSCFGMAIFAPITGGLIDWYSEKVGHTDYSLAFYSFDFLLIIASLSLFFMPLDTKLPSDSMFSDLKKILKMPALMMVVFFLFLLGNLWGFIESFLFFYLKDLGAPNYLLGITVTVGTMSSVPFLYGSDKITGTIGHVTVVILAFFAHATRLVGYSLIESPWWCFPFEALESIAVHLMWVAAATYCAVLAPRGLLATLLGVCAVAHYSVGRGSGSFIGGHIIAKFGITTAFRIMGLFAVCSGLSYAFLNLVWLRKVEKREQDRREAEVTEELKGGGLKYKDQGTMMSLERLTVMIDQNHIGSITSLGRHSRSGIIRRGSLSAARPSIPNARTELLKSANEINQHRTRHNSERDGSARQIYPSLSSQGVNGSVLCEKEEIVYDEIKRKAQSYSSEKDETLYDEIKKKPETNSQDDKSDSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFG0</accession>
    <name>A0A6P7FFG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114329760</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028134769.1">
        <property type="nucleotide sequence ID" value="XM_028278968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFG0"/>
    <dbReference type="FunCoup" id="A0A6P7FFG0">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278968.2">
        <property type="protein sequence ID" value="XP_028134769.1"/>
        <property type="gene ID" value="LOC114329760"/>
    </dbReference>
    <dbReference type="GeneID" id="114329760"/>
    <dbReference type="KEGG" id="dvv:114329760"/>
    <dbReference type="InParanoid" id="A0A6P7FFG0"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014034">
        <property type="entry name" value="Ferritin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00204">
        <property type="entry name" value="FERRITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028134769.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20351" checksum="EE714F93F3C01D85" modified="2020-12-02" version="1">MSQVTHNFHKDCEDAINKQINVELSVSASYVYMTMAYHFHRDDVALMGFHKYFKECSEEEREHAYRLMEYMNKRGGKIILSEIKAPEKQEWTSPVEAMVDALNLEKGVNESLLHLHNVGSGHMDINLCDFLEQHYLQEQVDAIKEIGDHITNLKRVGEGLGVYMFDQRLDKEAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMD8</accession>
    <name>A0A6P7FMD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 protein epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329348</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134210.1">
        <property type="nucleotide sequence ID" value="XM_028278409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMD8"/>
    <dbReference type="FunCoup" id="A0A6P7FMD8">
        <property type="interactions" value="1544"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278409.2">
        <property type="protein sequence ID" value="XP_028134210.1"/>
        <property type="gene ID" value="LOC114329348"/>
    </dbReference>
    <dbReference type="GeneID" id="114329348"/>
    <dbReference type="KEGG" id="dvv:114329348"/>
    <dbReference type="CTD" id="42186"/>
    <dbReference type="InParanoid" id="A0A6P7FMD8"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134210.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29256" checksum="31376B9D9512C9FE" modified="2020-12-02" version="1">MSEREDNVYKAKLAEQAERYDEMVEAMKKVAKLDLELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESKGTDDKLEMIRQYRSQVEKELRDICSDILGVLDKHLIPAASSGESKVFYYKMKGDYHRYLAEFATGNDRKDAAEHSLVAYKSASDIAMTELAPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQLESEEGNKEQLQDVEDQDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQ05</accession>
    <name>A0A6P7FQ05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein amnionless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114332663</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138291.1">
        <property type="nucleotide sequence ID" value="XM_028282490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQ05"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282490.2">
        <property type="protein sequence ID" value="XP_028138291.1"/>
        <property type="gene ID" value="LOC114332663"/>
    </dbReference>
    <dbReference type="GeneID" id="114332663"/>
    <dbReference type="KEGG" id="dvv:114332663"/>
    <dbReference type="CTD" id="33199"/>
    <dbReference type="InParanoid" id="A0A6P7FQ05"/>
    <dbReference type="OrthoDB" id="10067964at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026112">
        <property type="entry name" value="AMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995">
        <property type="entry name" value="AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14995:SF2">
        <property type="entry name" value="PROTEIN AMNIONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14828">
        <property type="entry name" value="Amnionless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028318604" description="Protein amnionless" evidence="12">
        <location>
            <begin position="23"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028138291.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55641" checksum="25A492F4F87CB16F" modified="2020-12-02" version="1">MWVKMIIYFVICASYLVNSCTGRLVTYQRNYDIFDKRNWINHQVSKECNGLVINNFLGFTTFGKLEVKQLVLKEYAQILFEDDTEIILDPDSENKINCVATNGTEMNLHKWHNPDNWLLQGRLNGNEAIPHMERLPCEYDDVVFPKGTLSGGVKIYGSITVKSFKYGHDYWTNSDIAVAKNDEILGLFLIFMAYDIDFNIHNKACNDPSGCFCGNEAVNTYTCHYFRSHKTSNCESPITPEGFCHAICGASIIFNAKPNFKISSIDQKIKDYTADTYVSKVRDKNGEPAIQIIFTEKEFTGNSLEEAKHLYQILQNENILTVNASQFLSSSIYYNQGKNVRSAFAVIFGSLFSVCLVFGFIILLFGEHPTSARLRDRLGISSAPLTYRSIFFSRSSVSEGTGLIGEGQSMAGSIQNIPNSLETPVYSEIKRTFGTSSSNASSTEELTKENEEQNDKLEPVDPEEEMANQDFENYQLINTVAEEGELVDLSTLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSI1</accession>
    <name>A0A6P7FSI1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114333564</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114333564</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139256.1">
        <property type="nucleotide sequence ID" value="XM_028283455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283455.2">
        <property type="protein sequence ID" value="XP_028139256.1"/>
        <property type="gene ID" value="LOC114333564"/>
    </dbReference>
    <dbReference type="GeneID" id="114333564"/>
    <dbReference type="KEGG" id="dvv:114333564"/>
    <dbReference type="InParanoid" id="A0A6P7FSI1"/>
    <dbReference type="OrthoDB" id="6419576at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028259671" evidence="1">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028139256.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28760" checksum="771E3F33F847BF77" modified="2020-12-02" version="1">MKVLICGIICLFAFCGANPVNPSVHDVVSRALERIDYNNIIPKELITRLRFLTEADILGGSEITVFLNQYADTIFNNLQNFIRQHNWQNVDIPDTHLKISGGSVDLTRGNLNDLDTISRGGDVILTYEGDNKKLVIELPITFGDLRFHYHHHTKVLFISMSGEVDGTVKHIQVSAIASFDFNSNTVFLDHYDMKHSGDVTVHFSGNPVVDWLANAISAVVTTFMGQVIINVMAKFIRDNLRAVIENLNEAIAQIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUT6</accession>
    <name>A0A6P7FUT6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114331349</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028136693.1">
        <property type="nucleotide sequence ID" value="XM_028280892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280892.2">
        <property type="protein sequence ID" value="XP_028136693.1"/>
        <property type="gene ID" value="LOC114331349"/>
    </dbReference>
    <dbReference type="GeneID" id="114331349"/>
    <dbReference type="KEGG" id="dvv:114331349"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028136693.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24973" checksum="76BEF41216D3D4EC" modified="2020-12-02" version="1">MAANDVNIRLVRPDEQEAVRDHLRKFFYRQEPCNESVQIITEERPICHDLESFTLQFFNNGLNLVAEYNEKIVGVCLNVMLERDKFEFEEYPVKDERFVKVVRLLEYAERKVDLFKRYPEVNKILSIFVLSVDASLRGKGIAKKLTNKSKELAKEHGAQMVFLECTSFFSAAVAKSLGYELVWSLDYENYKVNGEVVLKPVHPHKSLQLFVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVE5</accession>
    <name>A0A6P7FVE5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114334594 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334594</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140469.1">
        <property type="nucleotide sequence ID" value="XM_028284668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503218.1">
        <property type="nucleotide sequence ID" value="XM_050647261.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503219.1">
        <property type="nucleotide sequence ID" value="XM_050647262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647261.1">
        <property type="protein sequence ID" value="XP_050503218.1"/>
        <property type="gene ID" value="LOC114334594"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647262.1">
        <property type="protein sequence ID" value="XP_050503219.1"/>
        <property type="gene ID" value="LOC114334594"/>
    </dbReference>
    <dbReference type="GeneID" id="114334594"/>
    <dbReference type="KEGG" id="dvv:114334594"/>
    <dbReference type="OrthoDB" id="6415921at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="2">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140469.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39392" checksum="F29539A7BC1AA1A7" modified="2020-12-02" version="1">MGQKPSRQQGQSINKKLPFALFSHKNETTQNINPQQPIRFQYKTKRKNNIKDLNCIKQNHVNIDNVHLNNFVKPNQSKETNCEVQCKLVKTQSTPVRTKSEPNLVPERTRYRNRRKKVKNDWNNETPQFGYEIQDVDAFLNKATIEKPANIPVVLAFPSVLYQTRVGGYQAEISLPLGMVVNAVFKNQHWLYVQTPHAEEGYVSYAACLPLGIIPPPEDDKLAPCWEKSTDVFPKPSGNLTDTEKLSSKSDCEGGGGSIRCRTRSRNAVSTCGEKSIDRLYLRAAANAKTKGVRHTLLVIVTDFSGSGDNNIAVQKGDVVFLVDASVKGWFYVKSKEGGEGYIPAAVAGHGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVR6</accession>
    <name>A0A6P7FVR6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">NPC intracellular cholesterol transporter 1 homolog 1b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114331412</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol(in) = cholesterol(out)</text>
            <dbReference type="Rhea" id="RHEA:39747"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136800.1">
        <property type="nucleotide sequence ID" value="XM_028280999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVR6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280999.2">
        <property type="protein sequence ID" value="XP_028136800.1"/>
        <property type="gene ID" value="LOC114331412"/>
    </dbReference>
    <dbReference type="GeneID" id="114331412"/>
    <dbReference type="KEGG" id="dvv:114331412"/>
    <dbReference type="InParanoid" id="A0A6P7FVR6"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1125"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1195"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1227"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="621"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028136800.1"/>
        </source>
    </evidence>
    <sequence length="1278" mass="143803" checksum="BAE7BDAF86F2BF58" modified="2020-12-02" version="1">MELLFRNSKLFYNSISSLFILVLIPNTLAKCLFYGQCHKDDKGHAQNCVKWMDNEPKPLNTSHAKYTSAVDYLREYCPFYVDSNGEPIDLCCDVDQVMTLGDNLASAAPFKRCETCITNLETIFCQFSCSPKQLEFVKDHNTRIDFETWQIYTDDVTVYIDEKYINQTFDSCKDVSLPATGESVMGSSCGNYGALWCTPQRWFDFMNNPDNMVAPFTIHYEIVNPEIDTEVYEQYIPINYTAYPCDQAWPNKSACSCSDCPANCKGVKYEKLEEEPLIWNIFNIYAFMVACLFLFVVISCSITVVILTRFILPKGLWKIGNCAAKVKSTNDKVYHVFESCFYHVAYIIAKERIKVLVMCAATVGILTAGSGMLKVTVDPVELWAAPNSESRIEKTFFDTYFGPFYRTNQIFIKTVGLNSFIHESQYDENLTMGPAFNAEFLVEVFKLQQQIENITFVSTNAKGKTVTKGLKDICYAPMRTIYSGTPTTNECTVMSLLGLFENDIDTFSTNVTKSYDTIIGCIQAPYSMNCLAPYGGPILPGIALGGGTKDKNYMDAVGVSLTFLTKNSVESSEIQDTLVWEKKFIEFLKDWDKSERPGNMSIAFSAERSIQDEIEELSKSTMWTVIISYTVMFIYIILTLGKFTSFNNILLESKFSLGLGGIIIVFSSVGCAVGLGGYFRIVTTMLTIEVIPFLVLAVGVDNIFIIVQTHQRKERDPNKSIPENIAETMAQVGPSMLLTSSSEIFCFAIGTLSSMPAVHTFALYATVAVLFDFILQITAFVALLALDEQRYEANRLDLAYCIKVKRDATLESKDFLYNSWKDHVTPIIMKYPVRLAVICLFTITTIMSILVSPMIEVGLEQQLSMPEGSHVLKYFQYMNDLLMIGPPVYWVTKGQVDYFNSEVNYKYCGGMGCAPDSISTQIFMAKLQPDLTRIATQANSWLDDFKDWSETESCCKYFKDTNYFCPHSYSSEDCDPCYFTLINKTTGLSQYNYYRKYLPHFLNDNPNPSCAKAGHPAYANGITYLSDENGYTDIIASNIMGYHTVLKKSKDYIDALKYARAISKNLTKTLDLPGVEIFPYSVFYVYFEQYLTIWSDTLRSLAVSLATILGTTFVFTGFSIMQSLILTSTAIMIISHMMGLMYLWGISLNAISLVNLVMSVGIAIEFCGHMVYAFENSAKHNALDRATDALAHTGIKVLSGITLTKFCGIIILAFASSQVFRIFYFRMYLGIVIIGALHGLVYLPALLSFLGALKYSTPAEKDTEKDTHVKENGFHKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVR9</accession>
    <name>A0A6P7FVR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">limulus clotting factor C</fullName>
            <ecNumber evidence="10">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114334592</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028140466.1">
        <property type="nucleotide sequence ID" value="XM_028284665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654821.1">
        <property type="protein sequence ID" value="XP_050510778.1"/>
        <property type="gene ID" value="LOC126887363"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FVR9"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027545354" description="limulus clotting factor C" evidence="12">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028140466.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32285" checksum="9527DE8AF2FF821C" modified="2020-12-02" version="1">MHQLLHLIVVLAFTFGSTFQNEIEDHKNWKLIPTKTCGYSKEAQRRIVNGKPAKLNQFPWMVQIFSRKEKNRDSFICGGSLINNRYVVTAAHCIGKEKIKNVRIGENTLTPEITKRRLKDYKVAKVTVHPNFNISGTEDNDIALIRLARSAKYSAAIQPICLPTANMLNKEFIGENVTIAGWGKTDTSKRPAKDLQYITIPVRERDVCNQIFNETLEQSKFCAGVSEGEDSCGGDSGGPMIWKNEESKAKYFLIGVVSYGLEKCGTGPAVYTNVPYFLKWILDSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FY51</accession>
    <name>A0A6P7FY51_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-tocopherol transfer protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114331993</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137485.1">
        <property type="nucleotide sequence ID" value="XM_028281684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FY51"/>
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    <sequence length="306" mass="35406" checksum="41009F35F20C9980" modified="2020-12-02" version="1">MTLVQPSPELQIHIRHELNEDVNTRESDLEHIKEWLRKQPHLPDTWDENRLMTFLRGCKFSLEKCKSKLDMYFTMRTACPELFSNRDITNPELKLIRELGHIPPLPGLTANGRRVVVLRSKKVDVDTYDIADIMKVVLMIGDVRLAAEEVGVAGDVYILDATVATAAHFSRINPAMIRKFLVIVQEAYPVKLKEVHVVNVSPLVDKIITWVKPFLKEKIRERIHVHSNFESLHKFIPKDVLPEEFDGTAGPLQVFHDQWMEKLKEYTPWFKEQENIKADESKRPGKPTNYDDLFGVDGSFKQLTID</sequence>
</entry>
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        </submittedName>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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            <begin position="1"/>
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    <sequence length="623" mass="72037" checksum="39786D472B39EE89" modified="2020-12-02" version="1">MSKQLYCLGMFKMILQRTIKFLVFMAICQYPSSTEASCYFPQEFQGEFIMQSPPSPQNLMMGTGIQYSHLNITENSIPIWGNCHRRIGNNFILMFNYSETLCVRCLLLKLRSSNVLQIFVATEETISKCFTNEKAAEANCPSEDTVVTREATEILLFKIKDNFGLPTERQYCPIDGNYIVNYKGTAQKRANECRGYDSILNSCPSGSTLNFMLRNCTFKGYDMKFECLGHWKGLDDETFVIFTDSRYMSNLRPKYRCAVYRQDPKTNKIQMALSRDSTCTTDLYNTTSGFETFSLVPRVERPWPAEVSFEMCSFPQWMYGDWEHLKIRSDTILYKDHNSFKTHTIKCAGILEDSDKYLIFSRTQCEEESYNCLRIANRGKNILEFQLGTNTSDNKVDVFTLCADENFKSDDWITQGRLEIPPGLSTGMCPITGEYTGRIPDATDLCTKLWSDCRAPELMYYQVSHCETEEIYEEREYQCLGHWRERHLLYTYTERKDVAAGTYECFVGSIITESEIYIKEAGEHCQRTVDPLRYGMKLMKKQPLYSCIERSTTPKHVPRTTTRSPTRRTTSYVPKSTTIMSDIESNDIPDIPREKTKSTSSSSMTGHAKYLYLVLFILNKCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2J1</accession>
    <name>A0A6P7G2J1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein slou-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114336995</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="13">Whole insect</tissue>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NK-1 homeobox family.</text>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF37">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="213"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
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            <end position="127"/>
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            <end position="219"/>
        </location>
    </feature>
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            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
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            <begin position="48"/>
            <end position="57"/>
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            <end position="118"/>
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            <end position="193"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061009"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028143174.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38874" checksum="9E54DADA42EC88B1" modified="2020-12-02" version="1">MTMLMMERIVTTTNHSSQEDKDKMHQSEQQIFRRKAKRKIDDTRDVEMCENSDEEDLTVDVENDDTLCPVDLTRRQENFGSYDNFHKTDSNSDFSSFKDDRKSPKSVCSDHSRSRSPRDQSPSVVPIQNRRLAFSVENILDPNKFTGRQTVYSDGFCCWKPLDGSRSSPDYEGSDAGKDHQSDDEEDLQSDISDDNKDPSKKKKSDSKSQNSGKPRRARTAFTYEQLVALENKFKTTRYLSVCERLNLAISLSLTETQVKIWFQNRRTKWKKQNPGMDVNSPTVPPPSVGSSGSFPGFHHTHNGLLYGHHVPYGGVYPLQTTSSGGYTPYFHLANHGHNLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3N9</accession>
    <name>A0A6P7G3N9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19">Cytochrome P450 6a2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC114337338</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143546.1">
        <property type="nucleotide sequence ID" value="XM_028287745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143548.1">
        <property type="nucleotide sequence ID" value="XM_028287747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3N9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050641684.1">
        <property type="protein sequence ID" value="XP_050497641.1"/>
        <property type="gene ID" value="LOC126878792"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641685.1">
        <property type="protein sequence ID" value="XP_050497642.1"/>
        <property type="gene ID" value="LOC126878792"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641686.1">
        <property type="protein sequence ID" value="XP_050497643.1"/>
        <property type="gene ID" value="LOC126878792"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028143546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028143548.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="58771" checksum="AFEA23485A9BFD5C" modified="2020-12-02" version="1">MSIITGAILYQLLGVVIGFATLAILYSKWAFQFWKNKGVPYFEPKFIWGNLSPPHKRTVPLGDELAELYQKGKDKGWKHVGLYNMVSPIYLPIDLNILKHVLTKDFNHFVDRGFYVNEKDEPIGAHLFAIGGKKWKNLRSKLTPTFTSGKMKAMFQTIADCGAQLNKYLVDELAHNEPIEIKDVLGNFSTDIIGSCAFGLECNSFKDPNNPFRTYGRQIFRRSPLQNLKFMIANNFPDFGRLIGITILDKEAVDFFSQVVRDTVANREKNQVHRNDFMQLLINIKNNKEEDVEHIDDGTSLTIDQIIAQSFVFFTAGFETSSTTIAFALYELSKNQNIQQKLRDEINQVLKKHNGRITYDSVSEMKYMNQIIDETLRIHSPAPFVTRVCVEDYVVPGYDVTIKKGVRVFIPIKGIHLDEEYYPNPKVFNPERFSDENKHDRDQYAHIPFGEGPRLCIGMRFGLMETKVALTNILKDFKITLSKKTVQPLKLQPLSVIPQVVGGIWLDMKKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5S1</accession>
    <name>A0A6P7G5S1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-galactose transporter senju</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114337969</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144356.1">
        <property type="nucleotide sequence ID" value="XM_028288555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5S1"/>
    <dbReference type="FunCoup" id="A0A6P7G5S1">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288555.2">
        <property type="protein sequence ID" value="XP_028144356.1"/>
        <property type="gene ID" value="LOC114337969"/>
    </dbReference>
    <dbReference type="GeneID" id="114337969"/>
    <dbReference type="KEGG" id="dvv:114337969"/>
    <dbReference type="CTD" id="33734"/>
    <dbReference type="InParanoid" id="A0A6P7G5S1"/>
    <dbReference type="OrthoDB" id="419167at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028144356.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39309" checksum="F18DB397D9EDB531" modified="2020-12-02" version="1">MSSLNWKELFPTKLSLIIFIGYILLFVNQGILVTASQRSDNNYNYNIVTVVLLTEVLKLVISSVLYCKDNSTGQLISEVVKHKHVLLLYFVPAFLYCLYNNLAFLNLSSFDPTTYFLLLQLRVVVTGVLFQAIFKKILSKRQWISLVILTFGCMLKQINLTQTTSNTSSSNNTKAASVSLGIDAIFIFIQIICSCLAGVYNEYLLKDKGASINIFVQNVFMYLDSIVCNVLLLILNGNILEAFVYENILKVLHYKVLLVMFNNAAIGIVTSFFLKNLNSILKTFASALELVFTALLSYLFFSIPIYLNTVLSIATVMGATYLYSQNPVHNPPKPVQDDSIEKERLLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5S7</accession>
    <name>A0A6P7G5S7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PiRNA biogenesis protein EXD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114338018</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144394.1">
        <property type="nucleotide sequence ID" value="XM_028288593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5S7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288593.2">
        <property type="protein sequence ID" value="XP_028144394.1"/>
        <property type="gene ID" value="LOC114338018"/>
    </dbReference>
    <dbReference type="GeneID" id="114338018"/>
    <dbReference type="KEGG" id="dvv:114338018"/>
    <dbReference type="InParanoid" id="A0A6P7G5S7"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990923">
        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052144">
        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="157"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028144394.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39577" checksum="B1DA82D341D0E229" modified="2020-12-02" version="1">MENEIPFKELYQQGDRLILKLYSDDIFEGHVADVGENRIELVNVKQHNNKNILSTIYTFYRNEIQTIQQLQERITEKQSASTSSEKVEDSSKIKLTDLEYDRLKDMSRDYTYIDQTDARYFQAVELLSRAETIGVAPLGVEKSRDGSIKLLGVSMWDKVYLFDFVNQRSNFQYKELQDILETEFTVKVIHEAGPLIDILYRKHKIFVKNVFDPQVVDLIIKKKETGSIPSNMSDISDLLTDYFNFPSSYLQNALETKDSKWTQRPLSDRRKGYAAQLVTYLIALRQHMERKIFSEMYEAIDNVHNYYYSLDSFQFASNWKSRNTPKEIEDVIPNLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8Q8</accession>
    <name>A0A6P7G8Q8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114337092</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143272.1">
        <property type="nucleotide sequence ID" value="XM_028287471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8Q8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656584.1">
        <property type="protein sequence ID" value="XP_050512541.1"/>
        <property type="gene ID" value="LOC126888383"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G8Q8"/>
    <dbReference type="OrthoDB" id="7760980at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="15">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028143272.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="56749" checksum="61692A99920FCC49" modified="2020-12-02" version="1">MLPQEEVPAEVTPVKKKGRKKDKKADKKRKRIERKKQKQRDELLRELKLSDITLRKHEKEWRQLLIDIELPHIRDELEFAWHNFELVIDNKDFAISLLMDELKHAEEQYTMNCNNHIEHIDKLLDMYKERIEELQRDYNKEITKLEIETETDVNELSEIFTEDENYLKTILFMLEMAKKEQKANIRAEYFSRLEEEETKNSQIIQRLRGILETVHSGIEEETDDFLSKYYIQIRDRKKEYDKLRAQDDALQELLSYQLEKIRKMYDYIKRLKQDLIDCEKILGRKLKDLETEYQYFHNSFNVLKLQLQKDQQVDANKMEVLTISHNETMSALQKIKEKGEHILHVAAVCRKLETQEEKIRPFPANYLRPERSNLNSEDENIEILDLFWQRVGQAEASRYAIIEERTFLKKENEILQKKLHEFCQCLQCPAGQTIDNEQLNWPPYIGHISKNVTEAHQEMKKYQLQNYPFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDR9</accession>
    <name>A0A6P7GDR9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114341026</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114341026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147616.1">
        <property type="nucleotide sequence ID" value="XM_028291815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654733.1">
        <property type="protein sequence ID" value="XP_050510690.1"/>
        <property type="gene ID" value="LOC126887306"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GDR9"/>
    <dbReference type="OrthoDB" id="6714092at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027699690" evidence="1">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147616.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25258" checksum="8769A2600DCCDE2E" modified="2020-12-02" version="1">MAKIVLFFCAIILASAAALPTQSADGGVVDIIKKVVHKLEDIMEKVFTEGPNFIDTFPDKYDDRLTKVLDVTRTVLTKIAQALKVVIDKVAEQSNDAGKKLVSCVEQHEADLVNIRVALVEGAGKCVKDSVVALVNTGAPLLKDLTEIHKQARDAAEEIDNCEGDNAAGLLCVFQVAMDILKVDLQIPDAVKGDIQPVIDAGKALHTAGKKCIHDQVPAFYANTGKLLGEIATCAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGY3</accession>
    <name>A0A6P7GGY3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114342431 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114342431</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149046.1">
        <property type="nucleotide sequence ID" value="XM_028293245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGY3"/>
    <dbReference type="FunCoup" id="A0A6P7GGY3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293245.2">
        <property type="protein sequence ID" value="XP_028149046.1"/>
        <property type="gene ID" value="LOC114342431"/>
    </dbReference>
    <dbReference type="GeneID" id="114342431"/>
    <dbReference type="KEGG" id="dvv:114342431"/>
    <dbReference type="InParanoid" id="A0A6P7GGY3"/>
    <dbReference type="OrthoDB" id="6624682at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027947249" evidence="3">
        <location>
            <begin position="19"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028149046.1"/>
        </source>
    </evidence>
    <sequence length="709" mass="78960" checksum="A7AE72D242F38CD5" modified="2020-12-02" version="1">MLWRWLVIGLVVVWGSGGRVNSNEEVDFSTVDIRKLATKTYGTELLLLESNYRDQGPYKFEDFFWTGSGDGPDDDQNWGSEENPSTIYKTKTVVTTVFIESPHSAYNETSKPNATKCSIDCVTSPNVPDGDIRPSPTYYNDTDLDDSEEDFDADRQFWLVTVLKGDGKDPMIVDLKNSLANLYKTAFQRQQEKHLGIENARSKREIKEKPVKVYIHRINTTVSNGHPKTEVLYHVSLDGKPVSAIVAANDMNLVSDEEVRKELGYPFLIKAEPYLKPSEPQGLSGAKNTWLFIGVSIVAFLVFLLILAFILGCAKKRKVGSPINVGIENRQHIFERGVGQDNKGFTIESQRRDSPTYVKYNTDNSTLLRNVSTVARPESSISSVSTSSGSLDISPLMAVKKHRRTPPKKPPRPRAALNRTVPIEVRRFPSELFDSDSSRKESPDTIYGGNMDPGVVSPKSYLSMPSVKSFPRVSIPEPLNKVLEPVSVHHLDIPDDEFREQDDNMEMYKRLGLARHASLGAVEDPGVIGPIVWNMHKERISHGVSVDEGINDLNVSTNLTKMRKRFHDLLDDTFSLFGSRKTSPVEKKRHDPHSRVAPSEIKSHSAVNRSTDDLKAPTPKPRPRTTDLRKVDQPPSGAPKGAWSSTAPSPLVRPLSAGIINPYPKVNVDHILAEGRFINPSDPAVNLIATIKSEIERISLPGSTTDLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL41</accession>
    <name>A0A6P7GL41_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114343989</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150646.1">
        <property type="nucleotide sequence ID" value="XM_028294845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL41"/>
    <dbReference type="FunCoup" id="A0A6P7GL41">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655152.1">
        <property type="protein sequence ID" value="XP_050511109.1"/>
        <property type="gene ID" value="LOC126887522"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GL41"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028150646.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28428" checksum="A316FDDCFC60E960" modified="2020-12-02" version="1">MLSRAAILSGQASKSLVANCLRATSTSTANTQVAKTDERPGEVAFARPARQEPGKVRMGFIPDEWFQFFYKKTGVTGPYTFAVTLSTYLVSKEIYVLEHEYYSGLSLLIMWVYGIKTLGPKLAAYLDKEIEEYENAWNESRVNQKQSLTDQISDEEKAQKSMEGQTLLVEAKRENVALQLEASYRERLISAYSEVKKRLDYQVEKQNIERRITQKNLVDYVVAKVRSSITADQEKQNINKCISDLAGLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPL2</accession>
    <name>A0A6P7GPL2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">52 kDa repressor of the inhibitor of the protein kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147143.1">
        <property type="nucleotide sequence ID" value="XM_028291342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPL2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657104.1">
        <property type="protein sequence ID" value="XP_050513061.1"/>
        <property type="gene ID" value="LOC126888720"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GPL2"/>
    <dbReference type="OrthoDB" id="10051013at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="177"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147143.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31064" checksum="5DF47CC6C1AC846A" modified="2020-12-02" version="1">MHILSSVHSLTLSLSRVLQSENQDLGEAIELADAAKQVLLERRENAEKDFRGIFKTVSEISAKYDIELRKPRLASKQTQRSNVQTDSVQDYFRITIYIPYIDLFLTHIQDRFLNHRKILSNFACLFPNKMKNFNEESCAQLFEPYSSILRDDSRDIWVDEVKLWRQRIAGKNVKNSLEALDVCNGDAFPNVHQMLRILAVLPVTTATNERSFSTLRRLKTYLRSTMSEDRLNGLASLNIHRDVEVDPQRVLEKFFSTPRRVNLLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQI3</accession>
    <name>A0A6P7GQI3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable elongation factor 1-delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114345542</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152161.1">
        <property type="nucleotide sequence ID" value="XM_028296360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQI3"/>
    <dbReference type="FunCoup" id="A0A6P7GQI3">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663668.1">
        <property type="protein sequence ID" value="XP_050519625.1"/>
        <property type="gene ID" value="LOC126893459"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663669.1">
        <property type="protein sequence ID" value="XP_050519626.1"/>
        <property type="gene ID" value="LOC126893459"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQI3"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF26">
        <property type="entry name" value="ELONGATION FACTOR 1-DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028152161.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28512" checksum="6A172B56E4A7DE39" modified="2020-12-02" version="1">MHPEEVSSVWLNRRYYEDAEIAHYENLTKAALTPLAGEVAKARQRLIESRDTFTSNVDSIDTGAIKFMEKKIVEYEKTITSLVTQLKALELRVAALEKTDSQTKPVHQINIQSVPSAKPAVNDDDDDDVDLFGSDSDEDDEAAAKVREDRLKAYEAKKSKKPVLIAKSNVILDVKPWDDETDMKLMEQHVRKVEADGLLWGAAKLVPLAYGIHKLQISCVVEDDKVSIDWLTEQLLEIEDFIQSVDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GS04</accession>
    <name>A0A6P7GS04_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC114340065 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114340065</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the attacin/sarcotoxin-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146590.1">
        <property type="nucleotide sequence ID" value="XM_028290789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GS04"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648038.1">
        <property type="protein sequence ID" value="XP_050503995.1"/>
        <property type="gene ID" value="LOC126882956"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8117451at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005521">
        <property type="entry name" value="Attacin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03769">
        <property type="entry name" value="Attacin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027606048" evidence="8">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin C-terminal" evidence="9">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028146590.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17730" checksum="48D7FBFEB2261361" modified="2020-12-02" version="1">MKYLIVFASFLLFAAALPVDVIEDEEGQEYALVPLHRERRQLKWGLNQSGYGLSHSGNLFNNNNNRLDGTVSASKAWGSHGLKPDTFGGRLDFANKPSSSSAFVGADRTRGYGTDVNAGLKYNFLQKKNWNGDISGQYGRHFGGPGGTGKPQAGVFLNLNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSC9</accession>
    <name>A0A6P7GSC9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 664-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114346142</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152731.1">
        <property type="nucleotide sequence ID" value="XM_028296930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSC9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050658149.1">
        <property type="protein sequence ID" value="XP_050514106.1"/>
        <property type="gene ID" value="LOC126889646"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GSC9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF434">
        <property type="entry name" value="FI01124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028152731.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46885" checksum="C477E07FF5A20091" modified="2020-12-02" version="1">METKQEPSEEICKIEPDNEAFDGPLDAFKIEIKEEPKTESVYNEFDYLDLNEFPVKAEVEQDEYKFTPFEEEQKPNEASCPKEESKLETMENLPAYSSQKENYTDQYAEGEILNKTVEVVTGQRPYKCGICFKPYSNAGHLKRHLKIHTGEKLHKCEICFNRFRTADYLKKHLRIHGGEKMKCKICFKQFSIVGSLARHMRRHTGEKPYKCETCFKEFTESGSLKKHLTVHTGEKCCECEICFKQFTTISSLKRHLRLHAGEKPHKCEICSKQFSTITSLRLHTGETPYKCEICFKTFTELRSLKKHLRVHTGETPHKCGICFKAFTESWSLKVHLRRHTGEKPHKCEICLKQFSTITSLKRHSRVHTGEKPHKCDICLKQFSEASKLKKHLRVHTRKTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GU39</accession>
    <name>A0A6P7GU39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC114342301</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17 18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028148903.1">
        <property type="nucleotide sequence ID" value="XM_028293102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028148904.1">
        <property type="nucleotide sequence ID" value="XM_028293103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GU39"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293102.2">
        <property type="protein sequence ID" value="XP_028148903.1"/>
        <property type="gene ID" value="LOC114342301"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293103.2">
        <property type="protein sequence ID" value="XP_028148904.1"/>
        <property type="gene ID" value="LOC114342301"/>
    </dbReference>
    <dbReference type="GeneID" id="114342301"/>
    <dbReference type="KEGG" id="dvv:114342301"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="223"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028148903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028148904.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59135" checksum="B6E572FEE239EAAE" modified="2020-12-02" version="1">MVDGKPNESTTSKAALKKEAKKAEKAAKKAEHKQAAGETQQNVVEEVDISVGKYGNLPLIKSETKHNERTFTSVSDLNKSVSGKTVWIRARLHTSRSRGKQCFIVLRQKEFTVQAILNVSDVVSKSMVKFSSGVPKESILDVEAKVSVVPNNIASCSQQDVELVVSQLWVVSLSAPQLPLQIEDASRPEKPEEEEGLNIRVNQDTRLDNRILDLRTPTNQAIYRLEGGVCRLFREALTKKGFVEIHTPKIISAASEGGANVFTVSYFKASAYLAQSPQLYKQMAIAADFEKVFTVGAVFRAEDSNTHRHLTEFTGLDLEMAFHYHYHEVMLTIGNMFTEIFKGLRDQFKNEISIINQQYPAEPFAFLDPPLVLEFNEGRKMLAEVGVEVAEEEDLSTPSEKLLGRLVKAKYDTDFYILDKFPLAVRPFYTMPDPQNPKASNSYDMFMRGEEILSGAQRIHDPVFLTERAKHHGIDISTIAAYIDAFKYGCPPHAGGGIGLERVVMLYLGLDNIRKTSMFPRDPKRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GY58</accession>
    <name>A0A6P7GY58_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional repressor scratch 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Scratch homolog 1 zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114348294</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154691.1">
        <property type="nucleotide sequence ID" value="XM_028298890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GY58"/>
    <dbReference type="FunCoup" id="A0A6P7GY58">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298890.2">
        <property type="protein sequence ID" value="XP_028154691.1"/>
        <property type="gene ID" value="LOC114348294"/>
    </dbReference>
    <dbReference type="GeneID" id="114348294"/>
    <dbReference type="KEGG" id="dvv:114348294"/>
    <dbReference type="InParanoid" id="A0A6P7GY58"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055059">
        <property type="term" value="P:asymmetric neuroblast division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001484">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028154691.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49096" checksum="388535341F2D6092" modified="2020-12-02" version="1">MPRCLMAKKFKAYTWPTERTDAPEEEDEEIDVVGDSPATATSCWGPSSPTEGATAPSPPPTSPHGTTLLYNGYLHDISSSSYTTFVPKSELPSQPQASYITLRNAEEPTDVRYEYNTSNQVPIKHKKSLAMTYTSTGTALSLPPKKKDIYRPYSLEDKPSPPFFHHTIRVPAEEDLHAAHAILDLSASTTVFLPPPPQIQIQEQHHILELPPDVQDPNIPQTMGDLSPSIKPAKTIAYTYEAFFVSDGRSKKRHDSEESPGNITVVKVTEKPKYTCSECGKQYATSSNLSRHKQTHRSLDSQAAKKCITCGKAYVSMPALAMHVLTHKLAHRCGVCGKQFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSADKNFECPRCHKTFALKSYLNKHLESACLKEEVISPLTCKEEPSSKEITVATPVPVRVYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H3S2</accession>
    <name>A0A6P7H3S2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114344008</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114344008</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150660.1">
        <property type="nucleotide sequence ID" value="XM_028294859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H3S2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642740.1">
        <property type="protein sequence ID" value="XP_050498697.1"/>
        <property type="gene ID" value="LOC126879571"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H3S2"/>
    <dbReference type="OrthoDB" id="6741510at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="166"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028150660.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45607" checksum="01B2B1C8F6D44F63" modified="2020-12-02" version="1">MSSDSDEEEVLLLIALLKRKKRKWVDNVNLKRHRYGEYHRLCKELESNEDRFYYYYRMSKDCVEEIYLAVKDDIMKLDTTFRRAIGPKERLAICLRYLTTGDSYRIIADSFRVGRSTVGCIVKNVSRAIWTNLYPKYMPTPTDDTWRQSEIGYRENWNFPNCLGCIDGKHIAIKCPPNSKNRSIEYENPDSIVLFTIIDPFNKFIIVDVGDYGDLYDTRIFEKSVLYRDILSKKLLLPSKPLPGMEECVPHVLIGNEGFVIQRFLMRPYPRAATFNDKCKMHFNDRIWQARSVVQTTFNNLTEKWRIFNRPIETNVDNIMHIVKAACCLHNYVSIKQQGPVSIESQITISNLSKALTPIRSTNLRSSVAVFKVRDTFAAYFYKDILNCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H7S9</accession>
    <name>A0A6P7H7S9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114345363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114345363</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151990.1">
        <property type="nucleotide sequence ID" value="XM_028296189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H7S9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028296189.1">
        <property type="protein sequence ID" value="XP_028151990.1"/>
        <property type="gene ID" value="LOC114345363"/>
    </dbReference>
    <dbReference type="GeneID" id="114345363"/>
    <dbReference type="KEGG" id="dvv:114345363"/>
    <dbReference type="InParanoid" id="A0A6P7H7S9"/>
    <dbReference type="OrthoDB" id="6886258at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028151990.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20491" checksum="FC0E31AB31AB3529" modified="2020-12-02" version="1">MITTKRQQTDETIDSYMIYLKQLAKECNFTAVDADTNKNDTIRGAFIAGMTSTKIRSRLLESLTLTLEETCNIAISMEMAGLNSQVYASQNSTLSALPGNYQFESQRSPTNFELVIVTAATNSTANSSRSEQIFFCDGPIHPRKNCSARESICKSCNKKGHFAKVCRSKSTSAFTNVSEGYDNCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H9F2</accession>
    <name>A0A6P7H9F2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114349040</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028155272.1">
        <property type="nucleotide sequence ID" value="XM_028299471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H9F2"/>
    <dbReference type="FunCoup" id="A0A6P7H9F2">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299471.2">
        <property type="protein sequence ID" value="XP_028155272.1"/>
        <property type="gene ID" value="LOC114349040"/>
    </dbReference>
    <dbReference type="GeneID" id="114349040"/>
    <dbReference type="KEGG" id="dvv:114349040"/>
    <dbReference type="CTD" id="9107"/>
    <dbReference type="InParanoid" id="A0A6P7H9F2"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15738">
        <property type="entry name" value="FYVE_MTMR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13210">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14532">
        <property type="entry name" value="PTP-MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000135">
        <property type="entry name" value="Myotubularin related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="15">
        <location>
            <begin position="123"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="333"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028155272.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="78149" checksum="F55A29C0F208693E" modified="2020-12-02" version="1">MDHIKTPKIENVRMLDRYSKTPSHGTLYVTATHLIFVDPDAKKETWIHHMHIASLEKLPLSTTGSPLLIRTKTFLSVTFVIPKERDCHSVYVTLQQLSQPAKVDQLYCFSYTPPIEEIQRPVGWSFHDLQSEYQRMGVPNEQWCLTNLNKGYELCDTYPQLLYVPSKATSNILTGSSRFRSKGRLPVLSFLYKNKASISRCSQPLSGFSARCLEDEKMMNHILKTNPNATYMYVVDTRPKINAMANRAAGKGYENEAFYENIKFHFLGIENIHVMRNSLSKVVETCEQRNPTMASFLSGLESSGWLRHIKSILDTSLFIAEALLEGISVLVHCSDGWDRTAQVCSLATVLLDPFYRTISGYQTLIEKDWLAFGHKFSERCGHIQTENKEISPIFTQLLDATWQLMQQFPMSFQFNETFLFTLHDHVHSCQFGTFVGNCQKDRLEWRLSERTFSLWGYMANHLNEYINPLYSTEESPEILLPNLIPQNIKFWRSMYCRFESGVHPREPQADLLLVTSDYVFSLDEHVKFLTKKLSSVKSLITRNVEKKKNKPKRDQLCNNVYLDNKTQYEKKASREMENAEQDHPLKNQHKVTEELLDMDLLAKEVDSVAVDWKPLRNATECSCSLTLDQISKKMHCRKCGDVFCQRCITKKVALPGHLSQTPVPVCKPCFDTVTSPAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9L1</accession>
    <name>A0ABM5I9L1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128053.2">
        <property type="nucleotide sequence ID" value="XM_028272252.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272252.2">
        <property type="protein sequence ID" value="XP_028128053.2"/>
        <property type="gene ID" value="LOC114324414"/>
    </dbReference>
    <dbReference type="GeneID" id="114324414"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="417"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1823"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2019" mass="226217" checksum="EA344CC573CCB503" modified="2025-10-08" version="1">MEDLLLSIVKEAGNVKLYNLKQRAQEAHDLLLSQNCLLRSPSHELRSVCFVPLKLSLESKKSKLVSSALSGFNKLIRDERFQYGTEPEDDSLWLPAQLLLATSSLLSQCEDTQVHILRVFLNLACSTSWALNGRLVMLILGRCGDAYDIGTQPVKASAQAAASQTLTAFCSFLDEECEEIRQQQQKHLNSGSSTEMVYTKTSAVACFNEAIPVMQYICSKLEETKVLTKSTDIKIFLLECLLTFVSTLPNTVHSNIHFTTFLWQRFCPSLLAILGTPGDPMVHSLTTSQAKIIYSIGIQVVRLVGRERALRPVLEALFHRMLLLPSPQKRLEPLKAVKELLRSPGRLADLLLLSGPIFRHAGDDMAIIRLIMDSIEESAQCNDTSVLLASVDCVGALLETLEALCKGEGLNHESAEITNSRYITLKQADYSGPLTYESMARLPKPYRDVVANLKYHSDSDSSGIEGNIPENEGGTESDCSGATEGPEDIILSDDSIMDDESFLTNQELQKLYKLPRSFNLGRPGTDECNTDIERHNARYFVKTLLHSLLPNILSLRSSIQVDEVLQEFASKCCQHNSTPNYEISTIMNADGIYLATYSALLLDLKLIQSGQYEDKNIPVPITEDQFVEEVHGSGVLVYVSATWLCELYQNVLSKSLLISAGYDPTSSYQPALINMLTDIGGLSVSQLLTDWQKLQRVQVSTETNPEIEAGIKLSRRILTCCWTSVISVLGLPLAENTNSTGTPSALSILVARRARLKHRQKLKDEITSSCLEGLHKVASLSNVLKLQTKSSSILALLSASSCKNQGSKLLASHALSLDVLLSKGLELGCHSSACWPHVFSACIAVSTLEHSLFSKTGSTQLLMVAQNPQNNVITSTTRSGSQEKLHMPFNVTGDEETVDIYSFLHNSSHSDINDTSISDIVEKSGANNIQGQCMLSGVYAAKICCILSQKSDELFHTAALRLSLPGLCSFLTELCKASHIQLFTKYEESPRQQKKWWKRELEIQQKPPVTLLLHRIGEVTLKSIKSGRPLLHIMKIWSIVGPHFMQAACHKERAISKKAVTCIHDAVTTLLNEQAELPHFHFNEALIKPFENLLCLDMCDMDVQDQIVACLCEFVEANRTEICSGWKPLFGTLRVANTRNNAAAILDVFKIFLSTDNTLVFANAALDYILCLLSHIKNSNVEETSESTQNTTQQNDWNKSMFLEKEPDFPSKLLLGPVDVCIESLKLLQKCASILSVIYNMPKCPTFNLTHRINIETNPQLVDPVLQNSEINYFNQVNFSKVNYDDLSIKYDLENCEKQKITLGKMDKQSNILKIYYILLEGLASASTLAVTKNQSYVIETLFKLIRDLTKNPGINFGFYCINHILLPMVQNWLRQNANIQKPGEVWQNFKHCCGLASELVVDYLYDLHKSDANLVNEDHPGATLALKQLLLILIDCISQPSENIARLGSSCMRHIILSAGKILSIRQWEILVLALHRACAISLNPLYQLCLVFKENSDSFYGDLATVKVAARKDTDLSENERLYELAQQVFSSQCQTHCTNCQRKPCTCDVSKGKVTEDRNFVFLLYPYNSSTIINPDLYTIRVPFKNLVVGILAHQMLIQTVSSVLLQNLNHITPILNILHINSCSLRGILTTVNAKHVDILLKCLEMSNMRAAEFDVRPGLKFLIQKVGNFKKAANLYVQANTSEVVQIIVLIELCLDGIEKYAIDPKNLRKILTQEEKQNFLTDLDYIENFLKKLYTKWNNLCSSYMSLTIAIPEVTDELNNEPFIFTKHLKTDFKQEESDNVSISTETDSYLEKDILPDIKSDEAIIYTNESNKTWLPKKENLKQRSNSADNSTDDETNEMAVRYNKLTYKSYKTEVNAIKYDKNTLLQMRKSTISSDNINSIYNKSHELPVMTTDQKRVKDDSIITDNKQVLDSSFVPNNNLSSTQPVPAEILQQRSISMFKDLETYKTTRIETMEACLELLTSLSTEKLSPLATVLKDGAVSLIGAQDEKIKNSTEILLQRMNISYVDHDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE42</accession>
    <name>A0ABM5IE42_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130806.2">
        <property type="nucleotide sequence ID" value="XM_028275005.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275005.2">
        <property type="protein sequence ID" value="XP_028130806.2"/>
        <property type="gene ID" value="LOC114326591"/>
    </dbReference>
    <dbReference type="GeneID" id="114326591"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046647604" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130806.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="164" mass="18218" checksum="0EC94E9905353A40" modified="2025-10-08" version="1">MKYIYFLFIYFLVALAKAEETVSLEGKLPKCECRDIIDEILCKLTENSEKVLKIQAKLAKVVKETNEILTEAKENSAQVKEIVAVSTLLKSQVNSTVTVVTANTAAIIKIKNQVHDHVLNNGGDLEQTLIGSSCKLNQIRRVFIGLGNCQCRKPDTDEANTEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQC7</accession>
    <name>A0ABM5IQC7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138759.2">
        <property type="nucleotide sequence ID" value="XM_028282958.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282958.2">
        <property type="protein sequence ID" value="XP_028138759.2"/>
        <property type="gene ID" value="LOC114333129"/>
    </dbReference>
    <dbReference type="GeneID" id="114333129"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411055" evidence="2">
        <location>
            <begin position="27"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138759.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="509" mass="57363" checksum="4E13CFC4206D2269" modified="2025-10-08" version="1">MFSCQKMKSIFFVFLVVLCTTNVVFTHHPWYPDLPRNYYGNLRYHEDRKMDGVHDRLQSRSYLPVDHDAFSVHALFSIPRLAVPEKEYIARIPLHKVKTPALVLPQALHPLPYSLVDHDSILRRIIHPAPLLRSPGIVSTRISPSSNILVDHDVPPPLPNHDTLPSPYNRIGRLPGQLPRTRVTVTSLDDALLRYGIPLLRKIGRVPLTKVTGAKSLFGRSPYARRTQPDFAMNDAVVAPSDLPVDNGFRSHVLRYPRINRHIHEKHNHDKHNHARSSPDIVANDALHNHVSDPLHNHDTLVRRSIPTSSRLVGFRPVRRNQGKRLDAHLHDALLELSDDSAVNQDTLIRDNVSKILPNILQIPLKRGKTSGPILSDAPVDHDHQNHNDHGPHDHDTNSRHTVPSYPRSRDDSVAALSDNHGHHDHDANSRHSFPSVFISGDDAPAALSGHHDHDANLRHLIPFNPRSTIPSRQDFDAVSSDAVLPGSHSLFDNDAVPRFRLPSRVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYQ3</accession>
    <name>A0ABM5IYQ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149969.2">
        <property type="nucleotide sequence ID" value="XM_028294168.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294168.2">
        <property type="protein sequence ID" value="XP_028149969.2"/>
        <property type="gene ID" value="LOC114343347"/>
    </dbReference>
    <dbReference type="GeneID" id="114343347"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149969.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="434" mass="50011" checksum="5636FD2F6C690C49" modified="2025-10-08" version="1">MNTENLNLSLDMGDDMKLDEVNYESDVSSSSSELSTGPSISSSSTNSSGALQRSRHKRDRSRSASPASKRPRSKDKLKSYDYITKLNYLFRDARFFVIKSNNSENIILSKAKGVWSTLPQNESNLNQAYKESRNVLLIFSVKESGKFAGFARLHGESRHDGSPISWVLPPGLSAKALGGVFKVDWICRKELSFLNTMHLYNPWNDGKPVKIGRDGQEIEPRVAEELCRLFPEDEGIDLLPILRLAKEAGKKSTLRSRDGHRHPKARMPIAARPSSFNYRGRGSSFSRRKYFLSRGLTTNNYRRSASPRPRDRYSMFYERDTSRPYTAAAAEAYVADYMRTMQHQLPPLPYVASSLYPQYDNLPPPRYYEGLPVPDYPASSRLASYSDKRSYDRSVDEFIWRTSQTERSRVRDRERDRGRDRERSRSHHRYRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZX9</accession>
    <name>A0ABM5IZX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acaloleptin A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154455.2">
        <property type="nucleotide sequence ID" value="XM_028298654.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298654.2">
        <property type="protein sequence ID" value="XP_028154455.2"/>
        <property type="gene ID" value="LOC114348013"/>
    </dbReference>
    <dbReference type="GeneID" id="114348013"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009382">
        <property type="entry name" value="Coleoptericin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06286">
        <property type="entry name" value="Coleoptericin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046493703" description="Acaloleptin A-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154455.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33300" checksum="D30F5F0C110A4467" modified="2025-10-08" version="1">MKVSAYLALLMVLAVVVSTSAKHHKKRKNWQVQPDVGRDGAGNVNAGVEVKNSGKNHDFEAGWSKVVRGPNRAKPTWHVGGTWRFKRSPDPQWEVNPGANRDENGNVNAGVELKRKGEKHDFDAGWNKVVSGPNRAKPTWHVGGTFRFKRSPVPDWQVNPGGNRDEDGNVNAGVEIKNKGKDHDFNAGWNKVIRGPNRAKPTWHVGGTWRFKRSAEPQWEVNPGANRDDNGNVNAGVEVKRKGEKHDFEAGWNKVVRGPDRAKPTWHVGGTFRFKRSVDIADDVPLVVFPEEEQQIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHH1</accession>
    <name>A0ABM5JHH1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-dependent secretion activator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497386.1">
        <property type="nucleotide sequence ID" value="XM_050641429.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497387.1">
        <property type="nucleotide sequence ID" value="XM_050641430.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641429.1">
        <property type="protein sequence ID" value="XP_050497386.1"/>
        <property type="gene ID" value="LOC114334073"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641430.1">
        <property type="protein sequence ID" value="XP_050497387.1"/>
        <property type="gene ID" value="LOC114334073"/>
    </dbReference>
    <dbReference type="GeneID" id="114334073"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01234">
        <property type="entry name" value="PH_CADPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033227">
        <property type="entry name" value="CAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057457">
        <property type="entry name" value="CAPS_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12166:SF8">
        <property type="entry name" value="CALCIUM-DEPENDENT SECRETION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25341">
        <property type="entry name" value="C2_CAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="423"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="563"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="944"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1443" mass="163785" checksum="1F5E510F602D6ECB" modified="2025-10-08" version="1">MIDPSSSEEDSEEEHGAGHHAGHHPPTHHHHRSSSHTQVAESSPYHQQHGSDLGSGTLEVPAPNASVAQRSLSPSSAVSAETISYSLGSSRANSLPRPTSPSPSLASEKTEVDIQEKQEREEEDRKRRIQLYVFISRCIAYPFNAKQPTDMTRRQTKITKQQLESIINRFQSFLKGETQIMADEAFQNAVQNYHDVFLKSERVVKMVQSGACSQYDFREVFRNNIEKRVRSLPEMEGLSKETVFTSWMAKFDCILKVMDDESKRPSRMQQNLNSELILSKEQLYDMFQQILGVKKFEHQLLFNALLLDSADEQAAAIRRELDGRMQKVSEMEKNRKLMPKFVLKEMESLYIEELKSSINLLMANLESLPVSKGSMDSKYGLQKLKRYNHRLHNHNNPYNVKHILMNYVTSFRSQGSLAKLEGDSADSDTQLTKLDVVLTFQLEVIVMEVRGLKSLATNRIVYCTMEVENGEKLQTDQAEASKPMWDTQGDFCTTHPLPIVKVKLYTENPGMLALEDKELGKVILKPTPLSSKAPEWHKMSVPKNLPDQDLRIKIACRMDKPLNMKHCGYLYAIGKNVWKKWKKRYYVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDYIEASSANLMVGMGKHLEGGRYFFNAVKEGDSIIYASDDENECHLWVMAMYRATGQSHKPTPPLTLQDKNSTISKIQGDADRARKHGMEDFISADPCQFDHASLFKLFQNLTLEYRLNDPYCSLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKNLMIDPTLIHYSFAFCASHVHGNSNNFRPDGVGSVTHEEKEKFQEVKDRLRVLLENQITNFRFCFPFGRPEGALKATLSLLERVLMKDIVTPVPPEEVRSMIKKCLETAALVNYTRLSSEAKIEEDLRGDTMVSPNKKLDDLIHLAELCVDLLQQNEEHYAEQLRKADRQPTSQAASAGANTNAQPAAPAPGTPGGREAKHPSVSRYCMPQHATYTPPDPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLAEQPADTWDSFPLFQVLNDYLRADDNLKNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWEIKGMGCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKLMACDMMESCIQRTESAFQQWLKKSVTFISTDYIIPSEMCAMVNVILDAKNQSLKLCAVDGIDLHQYHTKIDDMIEKTNANIVQGLTGKLMSVLEATLSKLSRYDEGSLIGSILSFTNVSGSGKDMGQGYVNFTRNCMDQIRQKITDELWILTFFEQWYTSQINMLCNWLSERLDHTLHPYQCTCLAHIIKKIYTDFELQGVMEDKLNSKAYQTIAQRMTTEEATCALTMGQAESGIEGLDEDADTRSKTKVTIMESLSGEEGNFVSNVGAVIGGKVGTIFGKGLGGIGSKLGGGTGSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI95</accession>
    <name>A0ABM5JI95_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497661.1">
        <property type="nucleotide sequence ID" value="XM_050641704.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641704.1">
        <property type="protein sequence ID" value="XP_050497661.1"/>
        <property type="gene ID" value="LOC126878803"/>
    </dbReference>
    <dbReference type="GeneID" id="126878803"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24849" checksum="9E4D4FB87E734BBD" modified="2025-10-08" version="1">MKLPFFLTIYPDLWKNMHFHPIKFIIAMKLGSLLYNAQKLLKTNETTPEKNSSVNETELKNVSFAEIIPLPSCYHENVVKRQNKANKQHPIVFTSTPLKEELEKKEDKKNKKTTIKSDKAKRNVFVTQEGSTLRQKSKRTKIALNYKICEEGESEIEDDDDVRDKNITEDICILCGEFGKNSELWLRCVYCGHWAHKACSNSPKDKKFICDFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIC7</accession>
    <name>A0ABM5JIC7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497692.1">
        <property type="nucleotide sequence ID" value="XM_050641735.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641735.1">
        <property type="protein sequence ID" value="XP_050497692.1"/>
        <property type="gene ID" value="LOC126878827"/>
    </dbReference>
    <dbReference type="GeneID" id="126878827"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="508" mass="57170" checksum="E9C140BA0820BEBE" modified="2025-10-08" version="1">MVNSGTFDTNALGSGDRNAKVTFTYPDAVSSDSVSTHCKTGASAWSSTADGDAAAASAQSSDESKSVEHETPRKNLDASTGNVDCSVDGEDKSTLCCSVPLEKVQGVLTFHPPKCEEPKPTRKLLDSKGRMTLLCLYCERSFASANLRQKHVERIHSVKKNRRLSSRKQNQLTVTPCIYCEKLGSSENTLKDLFQHLINEHSDKYFGCLPCEERFVINSLLSDHNVSHHQPVPEINEKAPAKLALTEDRSVKEVSVKLTRSKTKPKAEATDNPDRAKKSIRAKNAKLKELRSKKLTVKSSRIALNRRESKRLQVISDAQKKKRQKPAERGKQTNVNKSEPVPEKSSCINPYPEFDHFYRVKKITDHSIDNLKISSLTFDDVFDKTFFNRIKCNIEENLLHHIDGKLFKNEESESRISNFEKISTVQQEIQNSAPENYGCELSLNAVTPVASLSLNSQFGEDFESQIEYGSKPSKKKAQTKKDEVHYKYFTRRKFQVSFAISFIIIIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ26</accession>
    <name>A0ABM5JJ26_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 9e2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497940.1">
        <property type="nucleotide sequence ID" value="XM_050641983.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641983.1">
        <property type="protein sequence ID" value="XP_050497940.1"/>
        <property type="gene ID" value="LOC114329102"/>
    </dbReference>
    <dbReference type="GeneID" id="114329102"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="62502" checksum="B08FAC55BF3E1EEB" modified="2025-10-08" version="1">MWGREYRKKFNMFWILGAVLLATLTYYFLIKPLYFWKERGVPQKDFFEAFSFSWFGLFYRMTFTENIISLYRGFPGSRYHGFYQFNSPSLLIKDVDLIKQMVIKDFDYFNEHRVFAREDVDPMWAKNLFALTGSKWRNMRSTLSPSFTSSKMKGMFLLMKANAERFVNFYLSQNKDVFPVEMKEVSSRYSNDVIASTAFGFEVDSLAKPNNEFYVNGKSLTAFGSYRALFRFVFNIFLPSVAKLLNIRIIEESVGDFFTKIIEDSIKMREEKGIVRPDMIHLLLEARKGTSKADEQQTTDDTGYAIVEEHLKSEVKTDITNDDIVAQALVFFFAGFDSSSNLMSFLGHELCANPDIQESLRDEVKETMENCNGKLTYEALVNMKYMDMVVSECLRKWPAMPTLDRLCTKPYTIEPVLPEEKPVQLKPGDIVHLSIYSIHHDPELFPDPESFDPERFSEENKANIKPYSYMPFGLGPRNCIGSRFALLETKILFFYILRYFKIVPTEKTDIPIELDKSVFRIIPNKGINVGFERIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJT1</accession>
    <name>A0ABM5JJT1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498197.1">
        <property type="nucleotide sequence ID" value="XM_050642240.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642240.1">
        <property type="protein sequence ID" value="XP_050498197.1"/>
        <property type="gene ID" value="LOC126879187"/>
    </dbReference>
    <dbReference type="GeneID" id="126879187"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="438" mass="51131" checksum="4A74569F7D45D2F3" modified="2025-10-08" version="1">MEVKQEIGDETCKVEYSDLDDAFLDGFKCEIKKESNSQGTLGTNDYLDVKEHPINIKVEQHEDIHPFDQKTEKGCLQDQDEPKMETTETLIKDSSYDGNYMSQHSKGKTFNKNEKVATRQSRYKCEICLKEFSQLSNLKAHLTVSTGETPYKCEVCLKHFSQAGALKTHLRVHTGEKPFKCEICFKQLTTAHGLKYHLRTHTGEKSHTCEVCFKQFICLSNLKAHFKTHTGEKSHTCEVCFKQFSCLGNLKTHFKTHTGEKSHTCEVCFKQFNQAGNLKVHLRVHTEEKPYKCEICFKQFTTELGLKYHLRKHTGETPYKCEICFKQFNQAGILKVHLRVHTEEKPYKCEICFKQFTTELGLKCHLRKHTGETPYKCEICFKQFNQAGHLKYHLRVHTKEKPYKCEICLKQFTTEHGLKFHRRTHRKVVLKRKNCVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJT7</accession>
    <name>A0ABM5JJT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498204.1">
        <property type="nucleotide sequence ID" value="XM_050642247.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642247.1">
        <property type="protein sequence ID" value="XP_050498204.1"/>
        <property type="gene ID" value="LOC126879192"/>
    </dbReference>
    <dbReference type="GeneID" id="126879192"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045353039" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19898" checksum="6644493084BE8196" modified="2025-10-08" version="1">MECKLLCVAVAVASIAVVSSEKSCWGHKVVAEVRELFPYCKDIITTNSISENDGLNLDTKDSSEELCQNIRKWLDESHSDLGKISQFNICMSLNNDGLEFYQMKKVFECLPVLNNSVFEKNSKEIVYEHITDRRVFRSVRIYLNQEKTEENQKSVNDFLACIGYQPDSVFNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKU7</accession>
    <name>A0ABM5JKU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498563.1">
        <property type="nucleotide sequence ID" value="XM_050642606.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642606.1">
        <property type="protein sequence ID" value="XP_050498563.1"/>
        <property type="gene ID" value="LOC114330082"/>
    </dbReference>
    <dbReference type="GeneID" id="114330082"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="360" mass="42148" checksum="C50C059FAF937795" modified="2025-10-08" version="1">MLKMPPTPTYIENVSDKSDGKKKTFPYEIVQVCDKTNQELLNFFKGEKDRFLQIGPKKWLFPSGYEAEAANYYNFSIRPDDVFIVTFPRSGTTLTQEMVWLLENNLDYSTAAGIPLKQRFPFLEFSSFVHKKMMEQFLEENQSYPERCAMIENLCYPRWKHLQGTNGRRFIKTHLPLSLLPPNLLDSGAKVIYVARNPKDVAVSYYHLCRAHRTQGFTGDFAQFWNFFQSGLVSWAPYWEHIKEGWSRRHESNLIFLFYEDMNKNLDPVLQKLSKFLGKSYSTEELSHLSNHLSIDNFKNNKSVNNEDFKDLGILNRTEGNFVRSGNSGGWRSYFDDEINGQADKWIEENLRLLNIEFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLI3</accession>
    <name>A0ABM5JLI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_050498802.1">
        <property type="nucleotide sequence ID" value="XM_050642845.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642845.1">
        <property type="protein sequence ID" value="XP_050498802.1"/>
        <property type="gene ID" value="LOC126879661"/>
    </dbReference>
    <dbReference type="GeneID" id="126879661"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="10">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="258" mass="28330" checksum="7566FE432DB5D119" modified="2025-10-08" version="1">MIHRIWIFIYVNHFNKYKSHFNDHLFEISSISSTSIKAEVSPDIIAVPNGLSGKGITTRYWDCCKPSCAWADNVNTPDKQPLKSCRVDGEAVAPPNDPSGCDINGSSFVCNNNQPYVVNSTLSYGFASASFSGGIDTSMCCSCMLLNFEGQLKGKQFLVQLTNSGEEYQTNQFDLGIPGGGVGLFPKGCTAQWNAPSTGWGDLYGGVHTEEECNELPEVLQPGCKWRFTFMEGVSNPEVTFYQVQCPRELVERSGCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLU0</accession>
    <name>A0ABM5JLU0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498907.1">
        <property type="nucleotide sequence ID" value="XM_050642950.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642950.1">
        <property type="protein sequence ID" value="XP_050498907.1"/>
        <property type="gene ID" value="LOC114337262"/>
    </dbReference>
    <dbReference type="GeneID" id="114337262"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045664659" description="Acyltransferase 3 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="221"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="640" mass="74186" checksum="178B9686F9BC4CBB" modified="2025-10-08" version="1">MNFIFNIVFLFLLTVFSTTEGVVTDEDYASLPDLFHQDNFDRCMLFGNKTLYCCFEYELEPLSNENPMWKAMQALSKDTYNYRHDNLRHCICVPTTCPNVTEKFEGNTTLTKQINNCYDKKMFKYGFRGTVNNLTCDTNISKFPVDWIDVLVASFFIVYISFVLLCTSVDSAIKNWYDKEHENFANTSYGRIVTSFSLYASWNKLTTVKSTAEVDYLRPLQGLRFYNIIVVVLAHTFMVGLFSSVANTKFVETRSLFLGTIVMSSGVLSVSAMFCLSSTLLSYGIFSHFEKRKLTLNALVMMFINRYLRLVPPLAAVLLFKITWWRHVGSGPNWNRIVGQEYLYCRKNMWTNLIFLNNIIDPEHMCELQTWYVALDTQYYILLLLGLWYIKKHEKYIFHIIGGLLSTTILITFYINYINKFEALNIPRAESMYNMKNIRGNPHFHKQHCSAIGNTCGPLLGIIFGYITYKTRNVEMFKQKKMWKILFYIFFYVPALSIIIVPSWYVLVLRPEYDPLMSSFIHVISRPIFLMSLGFGMYGCLHGIGGITEQVLKWPPMYILGRLSYSVYLVHCTIILSRQATARTPAYISEIQIIYHLLADFAASFLVALLLTLFFEMPIAAVTKYIILPKHSKGVEEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMQ7</accession>
    <name>A0ABM5JMQ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein okra</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499215.1">
        <property type="nucleotide sequence ID" value="XM_050643258.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643258.1">
        <property type="protein sequence ID" value="XP_050499215.1"/>
        <property type="gene ID" value="LOC126879915"/>
    </dbReference>
    <dbReference type="GeneID" id="126879915"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="160"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="490"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="760" mass="86725" checksum="EDE5130808C49F7F" modified="2025-10-08" version="1">MRRSSAPSQKYKTEDTLTKNVNSGFKSPFTSKRTRDHSKDTKNTKRAPLSQVNTEIIFVSDHEELIKKLSRPFKCPVPNYEGSNSTRNLGIRRPQVKRALYDPNTPNALVLYAPPEISEHDKLKSDKTILVHVVVDPLLGNILRPHQREGVKFMYDCVTGVQIPGSYGCIMADEMGLGKTLQCITLLWTLVRQGPEAKPLIEKGIIVCPSSLVKNWSNEINKWLKGRLQSLIMDGGSEAKKKLTQFMQGQGRTAIPVLIISYETFRMHAEILHKSEIGLVLCDEGHRLKNCENQTYRALMGLKAKRRVLLSGTPIQNDLLEYFSLIHFVNEGLLGNASEFKKKFENYIIRGQDSMATDLERQHASERLIELTTIVNKCLIRRTASLLTKYLPVKFEMIIICQLTPLQKQLYLNYINSELIRKSVTGVESQGNTLSTLASITTLKKLCNHPDLVLDKILEGSGGFEKSRHILPPKNGPNDVRPELSGKLMLLDYFLANLKANYSDKIVLVSNYTQTLDLFEVLCRKRGYLYVRLDGTMSIKKRAKVVDNFNNPESKEFIFMLSSKAGGCGLNLIGANRLIMFDPDWNPANDDQAMARVWRDGQQKPCYIYRFLAAGSIEEKIFQRQAHKKALSSTVVDMNEEAARHFSVADLRDLFRLEDTESDTHQKLKCKRCMNKIQIKNPPEEADCTDDLAVWYHCWDKKGLADMVLKQIWDMSKYISFVFHQKSAKQEVKKVVEEEDPDYNEKEESDFDDKDSDYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNR9</accession>
    <name>A0ABM5JNR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499582.1">
        <property type="nucleotide sequence ID" value="XM_050643625.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643625.1">
        <property type="protein sequence ID" value="XP_050499582.1"/>
        <property type="gene ID" value="LOC114327955"/>
    </dbReference>
    <dbReference type="GeneID" id="114327955"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15927">
        <property type="entry name" value="7tmA_Bombesin_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="63"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="424" mass="48053" checksum="CA4C27261A3E458F" modified="2025-10-08" version="1">MNVPNDIFVWILCGLNTTNYSDICDNRTDAANDTVVIYPLETRPETYFVPVIFFVIFVVGVLGNGTLVMIFVRHKHMRNVPNTYIFSLALADLLVVITSVPFTSIIYTMESWPWGLLVCKISETTKDLSVAVSVFTLTALSADRFFAIVDPLKKFHATGGTRSAKRITIGSTVVIWILSLLFALPASVGSHIKPLPDEKNPLFYVCYPFPSEWLNDNYAKVMVLLKFFVLYLIPLIIIAIFYLGMAVSLITSTKNMPGEIQGIEKQIKARKKVAVTVLIFVAVFAVCFAPIHIFMLFFYLHPDSQELYNDFWHYLRITGFCLAYMNYCANPVALYFVSGAFKKYFNQYLFCKKKPTRSRRSTYPHQHTSISLLSVKRNQVSISRNDKQASINRSPDALAMQETTIALLDNGNASERSHSCNKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNU2</accession>
    <name>A0ABM5JNU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499611.1">
        <property type="nucleotide sequence ID" value="XM_050643654.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643654.1">
        <property type="protein sequence ID" value="XP_050499611.1"/>
        <property type="gene ID" value="LOC126880040"/>
    </dbReference>
    <dbReference type="GeneID" id="126880040"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="22827" checksum="81290AC2F5040650" modified="2025-10-08" version="1">MNNSTLEINASPKLTTQKKINNHLEDKKNLMGAINNDISLKDLLEAGPSHVPSPVCEKSLEEIRPLAKAGERTSKTGGRKRRTTAMLTDTPIKDELELEKQQRKKKKTKQSKAGLKNVKRDICSKKTKAKEIDSSSEEDECFYLICLELFSNSVSKEKWVQCTKCKEWAHEACTAGDILFLCAITVCPMRISDCIFLQIYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPZ4</accession>
    <name>A0ABM5JPZ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500012.1">
        <property type="nucleotide sequence ID" value="XM_050644055.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644055.1">
        <property type="protein sequence ID" value="XP_050500012.1"/>
        <property type="gene ID" value="LOC126880289"/>
    </dbReference>
    <dbReference type="GeneID" id="126880289"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="564" mass="66828" checksum="D6E99D7906569E23" modified="2025-10-08" version="1">MAKSHRRVGPKAQKPQTSVISNFDCNIKTQMDIKQEVSEAMYKVEIHNDVDDDFLNKCKIEIQEEFKKESIHDTFVYSDSQHFSSKIEVDPDESKLKPIEEIATNNENDFLREEDTLKIMKAYNVQSYNKDQHMSQRAEEKTLKCEICFKQFNHSSSLKIHLRSHTGEKPYKCEICLNQFSLASTLKVHLRLHTGEKPHKCKICCKLFNQSSSLKSHLRVHTGEKPHKCEICFKMFSQKSHLKNHYIMHTGEKPYRCEICFKQFNQAGTLKLHLRIHTGEKPHKCKICFKQFVQKSSLDVHIKVHTGEKPYKCEICLKQFSWSSCLKRHHVRLHTKEKPYKCEICFKQFSDSTYLKQHMKRHTGEKPHKCEICFKQFTEAKELRRHIRMHTGEKPYQCEICLNQFSHAHALKVHLRLHTGEKPYKCEICFKMFFQKSHLESHLLMHTGEKRYRCEICFKQFGQAGTLKLHLRIHTGEKPYKCKICFKRFALKHSLGSHMKVHTGEKPYKCEICFEQFAHLSQIKQHMRLHTGETRYKCEICFKNYSKQIDLKRHLKSHNGENPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR01</accession>
    <name>A0ABM5JR01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500362.1">
        <property type="nucleotide sequence ID" value="XM_050644405.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644405.1">
        <property type="protein sequence ID" value="XP_050500362.1"/>
        <property type="gene ID" value="LOC114330879"/>
    </dbReference>
    <dbReference type="GeneID" id="114330879"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046571290" description="GPI-anchor transamidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38449" checksum="C46ECB39FFFB7479" modified="2025-10-08" version="1">MGVFKYSLFLIIIGFIEAECFLNKNHTNNWAVLVDTSRFWFNYRHVANVLSIYRSVKRLGIPDSQIILMIADDMACNPRNPRPATVFNNADQHINVYGDDVEVDYRGYEVTVENFVRLLTGRLHPGTPRSKQLLTDEGSNVLVYLTGHGGDGFLKFQDSEEITSQEMADALEQMWQKQRYHEIFFMIDTCQAASMYERFYSPNILAVGSSLVGEDSLSHHVDPAIGVYIIDRYTYYALYFLENVTPQSNRTMGEFLKVCPKSVCISTVGVRKDLFKRNPDEVPITDFFGSIRPVDIIQDLVTVSAVSSSTPTILKEPVKPKKYKYIEPLVNFNKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS70</accession>
    <name>A0ABM5JS70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500788.1">
        <property type="nucleotide sequence ID" value="XM_050644831.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644831.1">
        <property type="protein sequence ID" value="XP_050500788.1"/>
        <property type="gene ID" value="LOC126880776"/>
    </dbReference>
    <dbReference type="GeneID" id="126880776"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="273" mass="30599" checksum="4C44E3009E294511" modified="2025-10-08" version="1">MTDNTSASVLQDNSASVDRISVKIPPFWPNDTEIWFLQVENQFTLANITSDATKFNYIVANLDTAYILEVREIIVSPPATERYVKLKLELIKRLSASQQQNIKRLLEHAELGDRRPSQFFRHLQSLAGTTVPDNIVRSLWLGRLPSSTQAILAIQAKASLDAVAELADTISEAIAPRAQISGASNALESTIDKLTAELADTKIQLASLSQAQAQTITYRRNRSNSRRRPYPRDSSYSREHNSDILCWYHYRFGDQAQKCSPPCKHQGNIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSV0</accession>
    <name>A0ABM5JSV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501014.1">
        <property type="nucleotide sequence ID" value="XM_050645057.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645057.1">
        <property type="protein sequence ID" value="XP_050501014.1"/>
        <property type="gene ID" value="LOC126880973"/>
    </dbReference>
    <dbReference type="GeneID" id="126880973"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="506"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
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        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
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        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="811" mass="95001" checksum="46FEADA388D86E79" modified="2025-10-08" version="1">MEVKQEQDILPVEGCEMKTEFIDFPNVSFHSSVKTEIKEDHYVAVADSLNNDTKTYFVNDSNRLNMDISVGGIKVEEEEEEDKAELVQIENVMELKREIKQEEITVEDVKDESPEGEDSSGLLENKMEIIWPALTPDKERHLSQLTEELLCAICYKKFSQKEDFKLHLQSHTRSKLYPCQICFKSFTYNFDLKVHMRLHTEKNPYQCEICFKSYTHSNTLKNHMKQHNDKKSYGCEFCLKSFSHTTSLKLHRRIHTGEKPYQCDVCFKSFSRSYQVKNHMKTHTEKKSYQCTICLKSCTKASNLEQHMTVHSEDKSFQCEICFKSFSRPNYLRSHLRSHTGVNSTSEFLIIHIKCETANYCMEANNCIAYPNIEFSPIGFRYTVKNEISKDLFKADLANTDTNNYFVHNNTLDKECMEADVEDIKLEEEDKAEEVIVQNDIVIKDEFNEFEQVHVENQFFSEGCKDEPREGYYSGFGERNKKEIIKTSPEPTFNKEQHMGQLTEELLCKICHEQFSLKDDLQTHYHKVHNKPYPCYICIKTYSNMKSLKVHMKSHDEIQPYQCEICFKTFSYLSALKRHLTMHSDENPYKCEICFKSFSRQETLKKHVKSHTGEKPYQCETCLKSFSQSAHLRIHLRVHTGEKPYKCEICLKSFSVRSALKGHMTTHTGDKPYQCEICSKAFTRSTNLHIHMRVHTGDKPDRCEICSKSFTVLCALEKHTRVHTHEKPFQCEICSKSFTKMGSLKKHTRVHTGEQPYQCEICFKSFSEKHNLKRHTITHTEDKPYQCKICLKSFSQSGYLKRHKEVHANVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTG3</accession>
    <name>A0ABM5JTG3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501228.1">
        <property type="nucleotide sequence ID" value="XM_050645271.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645271.1">
        <property type="protein sequence ID" value="XP_050501228.1"/>
        <property type="gene ID" value="LOC126881181"/>
    </dbReference>
    <dbReference type="GeneID" id="126881181"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="122" mass="14162" checksum="DB30B84B21CC5668" modified="2025-10-08" version="1">MLFLIATYILCTAGIIFFVMTNIRPDANWRLIYVLLIEILIGMGFSVVGQSIYDESYKIKDMFYNCPWMYWNERNKKTLLIILPCTKPIQVSCFDLVILNHSVITKGLKLVYTIMALVANLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVM2</accession>
    <name>A0ABM5JVM2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050501993.1">
        <property type="nucleotide sequence ID" value="XM_050646036.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646036.1">
        <property type="protein sequence ID" value="XP_050501993.1"/>
        <property type="gene ID" value="LOC114335306"/>
    </dbReference>
    <dbReference type="GeneID" id="114335306"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="318" mass="36184" checksum="B168664BAF25DB1E" modified="2025-10-08" version="1">MAKNKVILVTGGTGLVGSAIKEIIQLEKRTDETWVFLSSKDGDLCDYNETKKIFEKHQPTHVIHLAAMVGGLFHNMSHNLDFLRKNLKMNDNVLQISFESGVQKVVSCLSTCIFPDKTEYPIDETMVHNGPPHPSNFGYSYAKRLIDIQNKAYHQQHGCMFTSVIPCNVFGPHDNYNLESSHVIPGLIRKLNDIIQQGGNTFTVMGTGTPLRQFIYSLDLAKLFLWVLREYQEVEPIILSVDEKSEVSIKELAEEIAKAFDFKGEISFDTTKADGQYKKTASNKKLRKYLPDFEFTPFSVAVKNSVDWYRENYKTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JX00</accession>
    <name>A0ABM5JX00_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050502460.1">
        <property type="nucleotide sequence ID" value="XM_050646503.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646503.1">
        <property type="protein sequence ID" value="XP_050502460.1"/>
        <property type="gene ID" value="LOC126881863"/>
    </dbReference>
    <dbReference type="GeneID" id="126881863"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="271" mass="30459" checksum="AA54B41130895E6B" modified="2025-10-08" version="1">MVVLIFSWDCAVQISGMLFYLLILLLTLLVWNIESRFQKWAKYGFFSVFSYNLMSFLIPLWIFSPGDSANGLLPARGFRIFCRLLGLKYTLEGKENVNPDSGGVVLMNHQSILDLIVICILRPSIPRCSTIAKRSILYVVPLGLALWLCGTIFIDRKSPSKSQVTLNKTAKLINKKQARVLIFPEGTRNGGPKLLPFKKGAFHLAIAAQCSIQPVAVSRFTFLGKNKFTSGEIRIRILPAISTKNLTTEDIPRLIEETYQLMSKTVNEITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXE5</accession>
    <name>A0ABM5JXE5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502609.1">
        <property type="nucleotide sequence ID" value="XM_050646652.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646652.1">
        <property type="protein sequence ID" value="XP_050502609.1"/>
        <property type="gene ID" value="LOC126881918"/>
    </dbReference>
    <dbReference type="GeneID" id="126881918"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="220" mass="25856" checksum="F51B32CCBDCE9A21" modified="2025-10-08" version="1">MVPTEKLIELVKKYPILYDLSHEDYKNIRKKDKIWDEIGQEMKECREELKRRWRSLRDSYVRYLRVIKTRTGQGAQNKTWQWAESMKMFQPFLLFAKTSSNVPEVVTNVESATEKDDGVDVSRNEESEIGDISEVPLPTKNKEPATCADVTTPIVEPEPKKRKVRNVQNTKPTSVDSIISYFESRKKNRKRLHRFIVSIICRLDKTIFWKTSGRNKITNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXT1</accession>
    <name>A0ABM5JXT1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502742.1">
        <property type="nucleotide sequence ID" value="XM_050646785.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646785.1">
        <property type="protein sequence ID" value="XP_050502742.1"/>
        <property type="gene ID" value="LOC126882015"/>
    </dbReference>
    <dbReference type="GeneID" id="126882015"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="478" mass="52806" checksum="5002FF3C4A7C86F3" modified="2025-10-08" version="1">MVQIDKFDTMDRVQPPKQFFGKRHVQYLLLFSVNVLAYGLRNILNVAVISMVSKTPPEGVTTYPEWAGSKNVMLSSFFWGYVLTQIPAGQLAERFGPKLFLSGAMVICSLFSILIPICGAQFGYLGVMFCRIIQGLMQGFIYPSIHHLISAWVPLSSRAKIAGFVYAGGPLGTVIVMPIVGIISGSKLGWQTVFYLLGGVGFTWTACWIFLGLDSPHKHKNISQDELKFIQDGIVTNKKKEQLPTPWKDILKSVPFWAILVCHFGDLWGFWTMLTEIPTYMDKILKYDIASNSTLSALPYLIYCLLNLVMSPIADYLITNKITSVGASRKIFNSIGVFIPSVALLTLCFIGSEEKALTVFMLVIAVGCNTGILIGFHVNHIDIAPNHAGTLMGITNAIGNVAAILAPLAVDMFKHVGGYEESDKELWNIVFITAAVLFSTTGLFYVFGASGEIQPWNDKRPKQEDSVPEKEPMYQNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY55</accession>
    <name>A0ABM5JY55_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502873.1">
        <property type="nucleotide sequence ID" value="XM_050646916.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646916.1">
        <property type="protein sequence ID" value="XP_050502873.1"/>
        <property type="gene ID" value="LOC114327486"/>
    </dbReference>
    <dbReference type="GeneID" id="114327486"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="44"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="7">
        <location>
            <begin position="281"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="469" mass="53442" checksum="88FF0BC1C95950AF" modified="2025-10-08" version="1">MENCEILVSEQNISVGDATFYIKKPGKNEIKHINKTGSMSLTFRSVTNFIREIFLPVGYPESVSEDYWNYQVWDTAQAFCSTIIGAFTTRSILKGVGVGNQEANALSAAVTWILKDGMGMIGRIVFAWWKGSFLDTDCKKWRFFADILNDAAMCIELCLPYFSNYSMELLCVTSSMKSIVGVAGGATRASITHHQAIKDNMAEISAKDGTQETLVNLVGSILSIYLLNVFTDTTSEWLLIFTLMFLHLLTNYWAVKSLVFRTFNEQRLTLVLKSYFSIGTVLSPAKINESERILLGRGMNVRQICGFNIYTGVSLKKILRNWSAVDFKELVSIHKEYNYLILVNLHVRKIYIIISKGESAESLIAAKFHAVCLAIATCIFNNIYLDVYDKRHRNHRTPITKLISFMRAYQTSSMLMNIPFNHLLELQDFIKQEYQMFYTALQVNGWNLNSHALNIGQYRCDWKSIKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYW0</accession>
    <name>A0ABM5JYW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050503124.1">
        <property type="nucleotide sequence ID" value="XM_050647167.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647167.1">
        <property type="protein sequence ID" value="XP_050503124.1"/>
        <property type="gene ID" value="LOC126882301"/>
    </dbReference>
    <dbReference type="GeneID" id="126882301"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12304">
        <property type="entry name" value="RRM_Set1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="1458"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="18">
        <location>
            <begin position="1581"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="240"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="844"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1165"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1165"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1245"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1597" mass="182298" checksum="A668F1BFEA295921" modified="2025-10-08" version="1">MNGTTMERHGHGQANQKLPRNYKLIVDPLIKKGATVKIYRYDGVIPNDTSYPPVIPRDPRSNLTRIWARLETLDLPVPRFKIDQNYVGEPPTIEVTIFHLNDNIDTHFLRDMLQKFGAIEELFIYYHPVTSRHLGIGRAIFESVKSAKACVEKLNNTSVMGKILEVFLDPFGEKCKEKYEGFTTEKKPPQLPSTTETTPKTEEKTKVDGDKPYDPADDDFDEPFKKVKDKDVDNKLRDRDIERSIDRERDKDRYSGGRSYRGGDFPTPSSTDMGYTTGQSSEFSTSFGSAGTTPLNFDYHATIQPPPLPNHFPFAPSYHPIPAPPPTVWPTPVPTSQWSQDSWDRSPAKLPPGASLNKWSSSSNEKHHHSKNKERDYRDRDRDRDKEKDRDRDRKRDGVKRNHKENEREKDRNEHEENKPLDLDTRIALLLKEKGSGGMAPPFLNFGPDSDDESKPTEKLLKQVPLSTSLNSDDDDDRSSISLSDMAINPQAPDLDFVYPKKDENAPLSEPPSPFLSMEIYLNCHQLALEQAVVAKQREALETTALLKKVHIEMNKIGSDISSSEDELLTGESIQNNYSPIDKSDFRSELGMNKMEKLFYFLKDDDRMSLSSLSSNEKIEEVQPEPPPPPLPPQPPNPPHPTTAPPPPLPTLPGIFPTHYPPGLQPYPGYPAAHFAPSFPTHFPPPPPAYGQPDWRAYPFGAHQMYLPPLHFSQLPPLHPAQFNPYQLPPKKPENTKDDPHASTINTVIQQVTQELKNILKRDFNKKMVESTAFNRFEVWWEEESCKENKTKDKEEQLIDKAQLSRDNINVLLESTRENLYSSLNIDSSVSLGFLTALPKMPSFRRKKIPSPVPEDGDEQKVSDSEEIVHNSDSDVTRRERKTSVSSTSSSSSSFTSSSDSDSSDDSSSDSEDEEEATDRQVSPMSTSGTDTALEVETVGKEDAIVNADAMVNADARISADARVNADAVVNTDAIVHADTVLKDIKQDVTDELMDEDSMSPLRDGIEPMNKTPEPMQIDSDDLAASQQRSSETSPRKSLSYMDDSDSDLSDTERLILERRRLNTEYMEQIEKERQELMGQEVKHVDSRIRIEETRVVEKREKETRVVEKKEIRVERRRSVEKDVMDKSLEELEAERDALLQQVRNPEPPQSRHVEEVKIFDEKPKEKIEMVHEREIDQSMKKKRDLNGDVVTVKTKPESPTGQDSPHKHVFNEHSYCIQSSEKETVDQPQKDQPVQQLSAQSALNDHEYLSKEQKIEKVKKEKPPKPIKPRKHKEHKKLQELQNKLAYERQFAWGGSDPYSFHNVQHKPRDQLSEFSLMFEFLAKGIDKEDVEYIKRSYEELLSNDAMSYWLNDTHWVDHCMTDLYSSPPKRRKKDERVHVTGNARTEGYYKLSAHEKSRYKYHHAKSHAVIRSSTATVTKQGLSREARSNQRRLLAAFGGDTDSDLLKFNQLKFRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYCGQMVRPYMADLREQQYEAKGIGSSYLFRIDLENIIDATKCGNLARFINHSCNPNCYAKIITIESQKKIVIYSKQSIGVNEEITYDYKFPIEDAKITCLCGAPQCRGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZQ1</accession>
    <name>A0ABM5JZQ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503418.1">
        <property type="nucleotide sequence ID" value="XM_050647461.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647461.1">
        <property type="protein sequence ID" value="XP_050503418.1"/>
        <property type="gene ID" value="LOC126882496"/>
    </dbReference>
    <dbReference type="GeneID" id="126882496"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="9">
        <location>
            <begin position="41"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="468" mass="51270" checksum="1629B02D96CEEBA3" modified="2025-10-08" version="1">MIFMELVRNKFGSKSYLKIFRSYSKKPACKSKFPIINHHYDAVVVGAGGAGLRAASALVQHGFKTACITKMFPTRSHTIAAQGGVNAALSHFEDDCWKWHFYDTVKGSDWLGDQSAIHYMTKDAPRAVLELENIGMPFSRNKDGRIYQRAFGGQTLKYGEGGQAHRTCAAADATGHYMLHALYGEAVRHHVKFFIEYYVLDLLVKDDKCLGVLAWNLEDGTLHRFFSNNTVLATGGFERAYFSCTAAHTVTGDGTAMVTRAGFPLQDCEFMQFHPTGIYGCGVLVTEGARGEGGFLLNNKGERFMEKYAPKAKDLASRDVVSRSMSMEIMQGRGCGPDGEYIHLQLSHLPKEKILLQLPGIKQTAMDFAGVDILREPIPIVPTVHYAMGGIPTNYKGQALTQVAPSEDKLIEGLYACGECACVSVHGANRLGANSLLETVVFGKAVADAISETHCPGDVINIDEVNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0R0</accession>
    <name>A0ABM5K0R0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeotic protein antennapedia-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503775.1">
        <property type="nucleotide sequence ID" value="XM_050647818.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647818.1">
        <property type="protein sequence ID" value="XP_050503775.1"/>
        <property type="gene ID" value="LOC126882786"/>
    </dbReference>
    <dbReference type="GeneID" id="126882786"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16875" checksum="A8D64FE835D26D51" modified="2025-10-08" version="1">MVSYYGQSAGMYHQQQISGNGHFQANSSMHPWYSAAGYRQTPQLGSAPPGAYCEEQQMWHHHPAHHSVFQHDIPDFLHSGIPMLQHPQHQLDPESQLPSPPITGSDISSPGGQSGNISPHNNHGHQSRPTPARSPYEWIKKTSYQSQPNPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1A9</accession>
    <name>A0ABM5K1A9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503974.1">
        <property type="nucleotide sequence ID" value="XM_050648017.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648017.1">
        <property type="protein sequence ID" value="XP_050503974.1"/>
        <property type="gene ID" value="LOC126882937"/>
    </dbReference>
    <dbReference type="GeneID" id="126882937"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="138"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="387" mass="44788" checksum="D15B94A04C591ECD" modified="2025-10-08" version="1">MFQQRNEKGAFRNLFHHMKINDQEMFFKYTRMLPETFDSLLNLIKRHLLKRSRREYLSPELRLAMTLKYLAHGGSFQNVSWEFRVGHSTVSKIIFETCEAIWNVLKPIYVKSHDEIDWLQVSNQFLHRWDFPHTLGAIDGKHVQIQCPINSGSQYYNYKNHFSMVLLACCDADYKFLWVDIGGSGSEHDSGVFRRSQMGQDLENGIVKLPDSQNLLGSNIEMPFFFVADEAFPLKSYIMRPYPGKNLEEKKLVFNYRLSRARRTIENSFGILASRWRVYRSPLLCSIKTTEAIVKATICLHNYLRTEASPIYTPPALMDTISEDGELVEGEWRQITRADTNLTPAGRMGSNMAANAVTRLRDSLANYLTSDVGSVPWQQTYINRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1C7</accession>
    <name>A0ABM5K1C7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the attacin/sarcotoxin-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503992.1">
        <property type="nucleotide sequence ID" value="XM_050648035.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648035.1">
        <property type="protein sequence ID" value="XP_050503992.1"/>
        <property type="gene ID" value="LOC126882953"/>
    </dbReference>
    <dbReference type="GeneID" id="126882953"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005521">
        <property type="entry name" value="Attacin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03769">
        <property type="entry name" value="Attacin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046884466" description="Attacin C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin C-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="163" mass="17751" checksum="AC6D73CBEDB8455C" modified="2025-10-08" version="1">MKSIAIIAFCISAVVSLPLDVIEDESGQEYVLVPVHRERRDLTWGANQNGYSLGQKGNIWENGAHKFDGAYSGSKAWDSHGLKPDSFGGRVEYTNKPTKTTAFVGADRTPGYGTDLNAGVKYNFVQDKKLNIDLTGQVSQHQGGPFGNTKPEAGVYLNFNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1Z3</accession>
    <name>A0ABM5K1Z3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504207.1">
        <property type="nucleotide sequence ID" value="XM_050648250.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648250.1">
        <property type="protein sequence ID" value="XP_050504207.1"/>
        <property type="gene ID" value="LOC126883055"/>
    </dbReference>
    <dbReference type="GeneID" id="126883055"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="185" mass="21339" checksum="5FDAEEFED6F75933" modified="2025-10-08" version="1">MASTSGARAELRAVLSENSSLNVNFIDDRDDSVADKDYKPSGDDFPSQSSEDELQEPIPRLFKDKEVNPEKKKPTRWRQRNEEHYDRNERKRSRNSGQQYTSKKTKTIISSREIGEENSVLRKGRPAIIELSNIPKKYNEPLKIAKNKLDNIKSLLPYIPPVYHTFYNQLNAASEVNEEVEIVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K254</accession>
    <name>A0ABM5K254_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500350.1">
        <property type="nucleotide sequence ID" value="XM_050644393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504269.1">
        <property type="nucleotide sequence ID" value="XM_050648312.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644393.1">
        <property type="protein sequence ID" value="XP_050500350.1"/>
        <property type="gene ID" value="LOC126880506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648312.1">
        <property type="protein sequence ID" value="XP_050504269.1"/>
        <property type="gene ID" value="LOC126883083"/>
    </dbReference>
    <dbReference type="GeneID" id="126880506"/>
    <dbReference type="GeneID" id="126883083"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="347" mass="40503" checksum="D6E27DA5D3BE3610" modified="2025-10-08" version="1">MFWENERDSHNVLVSEALSRNKFEYILSHFHLTDNLTINTSDKFAKVRPLFDHLNAAFLKFGKCEEMHCVDEAMVPYYGRHGCKQFIHNKPIRYGYKLWVGASRLGYVNWMEPYQGATTNISEKYIDYGVGPSVVLEYADVLSTRWPNKRMHLFFDNFFSTLSLLELLSEKNFNATGTIRENRISNGPLTNSKEIKKEARGVFDFKKTENQNIIVVKWHDNSIVTLCSNAVGVNLLHRVKRFSRKERTNIQVSQPHLINLYNANMGGVDRCDQNLSLYRISLRSKKWYFPLVAHCIDVALQNAWQLHRQRGGDLDQLRFRRRVATTLLLQNKKKKHILKVISHLPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K412</accession>
    <name>A0ABM5K412_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504934.1">
        <property type="nucleotide sequence ID" value="XM_050648977.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648977.1">
        <property type="protein sequence ID" value="XP_050504934.1"/>
        <property type="gene ID" value="LOC126883428"/>
    </dbReference>
    <dbReference type="GeneID" id="126883428"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="286" mass="32043" checksum="E2B75FA00C3C84E5" modified="2025-10-08" version="1">MESKKRERSRNYLEEEKEHLIAIVEKYKHIIENKKTDSVWSKQKNATWERIAGEYNSTSKTGIRNGMQLKLLYEGLKKRAKKLRADDKVQTYITGGGTKVTLMTPQDDRIVAIMGPQIIPMESVYDSNITSQDVYQGDISQCEGDAMDAIQLLQSHTAMDIPGTSQAPPAMDIPSTSRAPPAMDIPSTSRAPPVMDVPSTSTGLTPIIIQDEKDSSSKQGGPAAAKTTKGSKRKCPSCEEMQDKKNLVLDKKLEILEIVRRKELVELKLKEIELKSKDPNWNPNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6K6</accession>
    <name>A0ABM5K6K6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505823.1">
        <property type="nucleotide sequence ID" value="XM_050649866.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649866.1">
        <property type="protein sequence ID" value="XP_050505823.1"/>
        <property type="gene ID" value="LOC126884081"/>
    </dbReference>
    <dbReference type="GeneID" id="126884081"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="3">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1133" mass="132475" checksum="8A163D3B2C0C5A28" modified="2025-10-08" version="1">MDPDNADGSNLRKKSVPSKNKQTRKIPTQKAVGEYPKGPVANLGTDYEWKLHCLFAVAAFKHFDNWSLANEYIEAGKFDDLVFKINDQCLLLQAKFKENRQVSDQKFWSTNPKSDNFSIYKYILSYNDIKWKLKDLKTNAIVLCTNANLPDTTFNSKKISENNIINKIFGNQVEIGSIKEENRKKFDEVKTYQENISDDDKDKLTWQNISLNHNDIEEFMSKFVVIKVSIEQIDKQISNLIMSMEKTNPSLKNLYIINHIHYWRNLPSKHSIYMTKNYMRYIWYREENDRSIQKFLNYEISFLNPYQFSLSINLIKAEHNLDLYLAKIVNSIKLIYKKQDKPDEMFFKEVLFLALQSDYKTIENTMECFEIKNVKYLVVSFLEMDENQSKEIYKKISRILDTNKQKKVIIVAKDFGFQDTNVENDQIRLNLFDEMTKEIVYNTIIEFQGEAVTLKHLLNNCKMANLMDGCKSLDIMDKSYISSLVKSAGESFDLNKDSYEELVESIKNKLSKDDSDLRNTTILEFQGQQIVLDDIVTICKIEHITDELFISKLINKEPLSLGKSSIPSITSEKYYVPRLLSMDFQNLFSEEFLLNELKTINKKVAVLTGPLGAGKTTLLENIILSRKLKDQNCSRLTWVINIELSRAAEYLQNKYFSHSLVGLLSYSEDTRGNFDIQALKSIEKIVVIDGIDENNSEYIYQVQDLIEDCSDLENLNILLVIMACRNYDFILKKFQNNPDVETVVIEPFNEQYQEIFFEKYVTFKNATSVQKTKDVFRHLKAQAPGIKKFCSTPFALRLLIDILLNNEDHVEHISKIFSKSLSVYEFYKLFLEEKKKTFVQQQKCDRGVINSIVVTDAFGAYLTKTRKFAASKSLPRELQELFNIDISPSINTSMLSIGIFEEGHGEFKFIHKSFEEYFAAEYICNFLSHKRISDSILLALLNKLFLNSQYAGVSGFFEEILDIKISDIIFSKISKKFGRVLSEQKWLESISLLVFQGYFNIVKFVFHEYDDFSKVINRRGFSGETALHLSAHYPHLVKYLVEKGAEINCVDETGLTVFHYIIMMCWDSEKYKKYFNMVFEKMRYRENFKSITFFDEYFKLIRRDQQKGIRCKVEYDIILDLIDYLKYHGLKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K866</accession>
    <name>A0ABM5K866_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Charged multivesicular body protein 2a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506381.1">
        <property type="nucleotide sequence ID" value="XM_050650424.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650424.1">
        <property type="protein sequence ID" value="XP_050506381.1"/>
        <property type="gene ID" value="LOC126884491"/>
    </dbReference>
    <dbReference type="GeneID" id="126884491"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26648" checksum="C886D4B16D88E761" modified="2025-10-08" version="1">MEWLFGKKVTPEEMLRKNQRALNKAMRDLDREKQKMEQQEKKVINDIKKLAKEGQMDAVKIMAKDLVRTRRYVKKFMLMKANIQAVSLKIQTLRSQNTMAQAMKGVTKAMQSMNRQLNLPQIQRILQEFEKQSEIMDMKEEVMNDAIDDAMEGDDDEEETDAVVNQVLDELGLQLNDTLSGLPQTAGSLPASGQKHPAAAAAVAGGGNGGTGTGGSGGNSGGGGGLSDADADLQARLDNLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K875</accession>
    <name>A0ABM5K875_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506390.1">
        <property type="nucleotide sequence ID" value="XM_050650433.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650433.1">
        <property type="protein sequence ID" value="XP_050506390.1"/>
        <property type="gene ID" value="LOC126884495"/>
    </dbReference>
    <dbReference type="GeneID" id="126884495"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="648" mass="72285" checksum="47E9C22AF6825E4F" modified="2025-10-08" version="1">MFYDIILLSSQHKGQYCKAWIAGTRGVKFIKEAEIKELDIAKLCDNIIEYVITASSSPTKRFSLRLSTILTNGAIKILRQQAVILQGECTKAMCVISIPATISVGYDEIGDVMSSLSPVAKVVRKKRAKKVKIINTPDVLQAMEQALLDEHEQTPILLEPAAEAGFSNKVISIVEEVAETRRQQPDEEFLSLGPALNVDDILLETGYPKPRSGSSSSIPYGTIGPQITVVADVHVAIVSPVPELIPSAMIDDVTQRPTVIEEIITEAEMLAEKRSTVIEEIITEAEMLPPTEIPPIATSTPMVDTAAAAKRAVRPGVLKEIQLEEVQEERAEKRAETRKPVEEQRVVSKKEQLVADEEYKRIFLPTSSTRFTRINRCLPGHEDMFVAEYTPSITVFPKKDIIYLYQTEEEQSQIDLEQAVRTAGSSLERTDRQRGTLSMQNITDEPIILPRSTLELQPKPGSTSTPKGKDRPTSLEQELPPNISTTPKGRIRLASEEPTLIDASPRKKAKRQVIPDESRPSDKTKEAPSAIEIELPEAVPSQRTEILSPIIEELLVLPSLPFQSSKLSPQTTVDFKGRHQRLMDIITKFNFDEGFPTIEDLSEKPLNKLHVARCFHDLLALCAFKYVTLIPEENSIELRHIEKGPRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K897</accession>
    <name>A0ABM5K897_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506409.1">
        <property type="nucleotide sequence ID" value="XM_050650452.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650452.1">
        <property type="protein sequence ID" value="XP_050506409.1"/>
        <property type="gene ID" value="LOC126884513"/>
    </dbReference>
    <dbReference type="GeneID" id="126884513"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289:SF3">
        <property type="entry name" value="BIFOCAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="830" mass="92212" checksum="5526BC5B2209928F" modified="2025-10-08" version="1">MESTTGVDSTPQWKKDLIARLRTQNKTSFGNGSKDHHSTPHHSSAHRTVHQPILTSKSESVASDISPRSSGTDASEQPCNVSPKMVQERVWVDNKPDHFAEMVANNGYHKESDSDSSEELHYGPGIVKKLKNKYLSLALRESNHRPSILRKATSLENLLDDDEPETKHSSDKYESRFNGVSATRNVPNRYRNSNRHHEMKRARSVETISRLDSQTNNVVSNRQSLHEETLIAVQKEGSDYPYRKIPDNTDIKSENKFSQRINRPKRLQPIMSEKEKPPVDFVKQAKMIFERRPEQRTRAPPQTGDVAAKVDSFNNIIVKAKVEAKATRKPQVKAPKPAPNEKKVIAPRSPTKTVTKSEEKQQLKHLELNKVPKTDVSLLSPIPDISRIIPAETVQGKPSSNLSETPDLILTSSPLSSIPPPLFKKPEKLNNEEHHSPKRVTSPLVSPSRVKPASPLISPSYSWSPSSNMSPTQFRPTTLTYDDDSDSPGYKKVSPTSINNISKDSGTSVYNFVHKEVTQNHLPLNKNVSETKVPPSEPLRIEVNGHTDSKIDTGAKLLQTQRPRSPPKFTPPPPPVNVVPEKKIEKSLTVTEIEKNSINTAKNKSSGSDKGSVEVVNKNVVPKKLRAKEPVSNTAIFDFTKKNRDVPDYISNDKSRTPSRPELPKPGEGGIILIPGATILESFTDEDEEILRSLEGPPSPCDVTFINDNILIDGKSSLSQKTKKAKLKLSFVEDGPEVYEYPSETSMMLDDSPVLSPVQLGHTVPNLSGSSLANYTPKSTESFQPGITRSVPQMAPPSSNKVESTEMEQNFELDEIDKPFSSGHTADILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KB60</accession>
    <name>A0ABM5KB60_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retrovirus-related Pol polyprotein from transposon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507422.1">
        <property type="nucleotide sequence ID" value="XM_050651465.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651465.1">
        <property type="protein sequence ID" value="XP_050507422.1"/>
        <property type="gene ID" value="LOC126885038"/>
    </dbReference>
    <dbReference type="GeneID" id="126885038"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="61893" checksum="0E44803E1D3820FE" modified="2025-10-08" version="1">MRQYNVGSPMERVAIDIAGPFPETDAGNKYILVAMDYFTKWTEAYALPNQEAATVAEVLVKELFSRFGVPLEIHSDQGRNFESALFQNVCKFIGVNKTRTTPLHPQSDGMVERMNRTMGKHLSKVVSENQRDWDQHIHLFLMAYRSAVNETTGQTPTCLMLGREVRLPCDLEFGCRPSEEHVAGEEYVDRLKLRMNNIHEFARQHIQIASDRMKDQYDSRCKNESFEIGDLVWLYNPQRRRGLCPNLQRQWEGPYEVKKKINDVIYRIKKLPNGKPKVIHINRLAPYAGSNETEEARVLQQEMKDAPQPSFKEFMSNYAERKSARFGVTTEVQQDLFGVPENVSLAHCVAQDLEMTKGISSVFNRKFGRLDELRNQHPKIGRVLRLEGGPRSLLYMVTRKSYTDTPSYENIWRALTNLKKIVCNYDIKDLALPKIGHAVENLDWKIVRSMLEVIFRETGVRITVCCMNPKMSYPSKTVDCYFFSMGVCRAGESCRFRHPGPSSRVADRDAQILRGEQCNKREILADRRITVNTSRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBD3</accession>
    <name>A0ABM5KBD3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507499.1">
        <property type="nucleotide sequence ID" value="XM_050651542.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651542.1">
        <property type="protein sequence ID" value="XP_050507499.1"/>
        <property type="gene ID" value="LOC126885114"/>
    </dbReference>
    <dbReference type="GeneID" id="126885114"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="555"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="807" mass="93098" checksum="F0E0021447F7CF2B" modified="2025-10-08" version="1">MMDRRKFYKKVISEFSQVRAKRKLSFEDEIASNPTQEQQSSELTSLLDNNQPLTSIENMGDHVSSSRIFYKNHQSISKLEIHKNTDVPQIECLQNNNTDGHNTETPPTLEGIVDTVAEFQRTIDSNVIDSNVITNTMENLVAKDAASDPINIKQNTKQSKRPRLNKKTYCEFISDNEDPFFTDGSSSWSDTGNTSSDTSTHNKRPKKKIVKKTQKVSKELASKTDDIDIVGEKGKRTKRINYRKNRKDLKNRGQEYTRADGTIRSKREIKPNPCIGKKCGNGCQNVTEERRLSLFHHFWSLSSARQRDWIVNMSRRNSIKRKRSKDSGKRSFSYEYYINDNEDRRRVCQQFLLNTLDITQTYVHYTLTNSIEGSAKDDLRGKIIPANKTKETTRQSVINFIKKLPALPSHYCRKDTTKLYLPVEFRNQKNLYRIYKGEKTSEGIDYVSEKIFLNIFNTEFNIGFHIPKKDKCLKCIKFDAANTEESKAEKEDHLMEKKASKERYSFHREMSQKRTDLICTSFDLQKVLNTPHGESMLLYYSRKYAVYNLCFYENGSREGFCYIWGETEGKRGSNEIASIIQKYIDLVDARISVKHLILYSDSCPGQNKNRIILSAIHNALKNCENIVSIQMNYLLPGHTEMSVDSMHSVIKGAVKNTIVWAPSQWATVCQLARKEPKPYNVSYLDHTDFKGYGTFADKYFRGNLTGKISKIRVATFKKSKINQMSVKYSMRSDEEEEIIPIIMGGINSKVVDQLYKTPLPITKTKYNDLKKLCDDQVIPKLFQKEYINLPSVTGIDTLAETDIDDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCK7</accession>
    <name>A0ABM5KCK7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507910.1">
        <property type="nucleotide sequence ID" value="XM_050651953.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651953.1">
        <property type="protein sequence ID" value="XP_050507910.1"/>
        <property type="gene ID" value="LOC114332980"/>
    </dbReference>
    <dbReference type="GeneID" id="114332980"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17048">
        <property type="entry name" value="Ubl_UBL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017000">
        <property type="entry name" value="MUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047977">
        <property type="entry name" value="UBL3_Ubl_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032572">
        <property type="entry name" value="MUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="116" mass="12891" checksum="82B052E8496CEA74" modified="2025-10-08" version="1">KRKNINLRLILVSGKTKEFLFSPSDSAGDIAQHVFDNWPDDWCQEAVSKAEILRLIYQGRFLHSNVTLGALGLPFGKTTVMHLVPRETLPEPNSQDQRQKSKGGNSSCCSTSCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG25</accession>
    <name>A0ABM5KG25_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509147.1">
        <property type="nucleotide sequence ID" value="XM_050653190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653190.1">
        <property type="protein sequence ID" value="XP_050509147.1"/>
        <property type="gene ID" value="LOC126886317"/>
    </dbReference>
    <dbReference type="GeneID" id="126886317"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF6">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 7, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="189" mass="20742" checksum="B0A79C4B6A2FE15E" modified="2025-10-08" version="1">MGIDQLVANRVSWMRKRDLHILTSGIHTYTGDARFSVRHPEHSDDWDLRIEYVQKRDAGVYECQVNTEPKINLAIMLNVDVFSLPDAQASISGPPEVYVKKGSTISLTCTVNVHSTPPSSILWYHGHAVVDFDSPRGGISLETEKTEAGTTSKLLVTKALLSDTGNYTCMPSNASPASTVVHVLNGFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGT5</accession>
    <name>A0ABM5KGT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509416.1">
        <property type="nucleotide sequence ID" value="XM_050653459.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653459.1">
        <property type="protein sequence ID" value="XP_050509416.1"/>
        <property type="gene ID" value="LOC126886502"/>
    </dbReference>
    <dbReference type="GeneID" id="126886502"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="528" mass="61714" checksum="249210B253E4ABC9" modified="2025-10-08" version="1">MEQEIKNEFYATSPEIKRECDEIPNLTIKSEIKEEVPDLYFCNDDNYESQIKTELCVEDVKVEQNPIDNVNMMEENPRSHCGSSYEDLQNGSLNKFKEDPLKCEVCLKQFTTKSSVKMHMLLHTGEKPFQCKFCLNWFRHKSNLKNHMQTHTGERHFECGVCSKRFPTKYKLRLHTHRHTGAKPYECDICFRRFSRPSHVAGHKTSLHSSDKPFKCEICFKQFSAISLLEKHVRFHIEQKPHVCEYCSKHFSSSSSLRVHMRTHTGNRVLKCEICSKEFKTNSHLKVHMRNHTGEKPYKCEVCSKEFTQMGQLSRHTLLHTGEKPFSCEVCSKNFRQKSALKTHMQNHTDDKPFGCEICTKVFTTNSLLKKHMRTHTGEKPYKCEVCSKEFTQMGQLSRHTLLHTGEKPFSCEVCSKNFRQKSALKTHMQYHTDDKPFGCEICTKVFTTNSLLKKHMRTHTGEKPFKCEICFKEFRDSAELKRHILMHTGEKTFSCEICSKNFREKRALKKHMQNHVKDKSSPSGSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI57</accession>
    <name>A0ABM5KI57_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509884.1">
        <property type="nucleotide sequence ID" value="XM_050653927.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653927.1">
        <property type="protein sequence ID" value="XP_050509884.1"/>
        <property type="gene ID" value="LOC114335751"/>
    </dbReference>
    <dbReference type="GeneID" id="114335751"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19142">
        <property type="entry name" value="AKR_AKR6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005983">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01293">
        <property type="entry name" value="Kv_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="112"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="457" mass="50996" checksum="1420DE55E870CB7A" modified="2025-10-08" version="1">MSQVALCNYSNNDTNNNNDNISEDSTQLPTIYRCRAPIASLDCMEEFSAGSALSALAERGGPGESTITKEQLLLSGLTHSAPAVPLQLARQACVTPGLRYRNLGKSGLRVSNIGLGTWPTFSPNLTEEQAEQIIVLAVESGINVFDLSEAHSGTRAEVELGRILSRKGWKRTSYIVTTKIYWSTRSEERGLSRKHIIESVKASLVRLQLSYIDVVIVHKADPMCPMEEVVRAMHYVICQGWVMYWGTARWSPVEIMEAYTNCRQFNCVTPIVEQTEYHMFCREKTELYMPELYNKIGVGLMAWSPISMGFTQGREDGSGSGGGGSVQLFSRASFKNKYSSFSWTEDETTAANKEGYSWMKDRLQPDESRRQAEKIRELNALAEKLGCSLTQLAIAWCLKNESVQCLLLGASSVDQLYDSIQSLQLIPKLNTNMVAEIERILENKPTRPPMVSTLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ51</accession>
    <name>A0ABM5KJ51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heat shock protein 83</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510229.1">
        <property type="nucleotide sequence ID" value="XM_050654272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510230.1">
        <property type="nucleotide sequence ID" value="XM_050654273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510231.1">
        <property type="nucleotide sequence ID" value="XM_050654274.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510232.1">
        <property type="nucleotide sequence ID" value="XM_050654275.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510233.1">
        <property type="nucleotide sequence ID" value="XM_050654276.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654272.1">
        <property type="protein sequence ID" value="XP_050510229.1"/>
        <property type="gene ID" value="LOC114343271"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654273.1">
        <property type="protein sequence ID" value="XP_050510230.1"/>
        <property type="gene ID" value="LOC114343271"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654274.1">
        <property type="protein sequence ID" value="XP_050510231.1"/>
        <property type="gene ID" value="LOC114343271"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654275.1">
        <property type="protein sequence ID" value="XP_050510232.1"/>
        <property type="gene ID" value="LOC114343271"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654276.1">
        <property type="protein sequence ID" value="XP_050510233.1"/>
        <property type="gene ID" value="LOC114343271"/>
    </dbReference>
    <dbReference type="GeneID" id="114343271"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="7">
        <location>
            <begin position="92"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="691" mass="78433" checksum="7A1982FC38927087" modified="2025-10-08" version="1">MSLSRFSRLLAFRHLRLVTRNHNFTNINSGRISSCGNQNLRRLLSTQTSPNEDEHHSIIKDTEKPTGESTKYEFKAETKMLLDIVARSLYSEKEVFIRELISNASDALEKFRYLAVSGDESAKKIQDVDRPLEIHISTDKQNRTITIQDTGIGMTKEDLISHLGIIAKSGSKAFIEQIKEKAAAGDNNIIGQFGVGFYSSFMVADKVDVYSRAVGEETGYKWSSDGSGTYEIQPAEGVQNGTKIVIHLKADCREFADDDTIKNVVNKYSNFVGSPLYLNGKKTNIVQPLWLSDAKNVTAQQHNEFYRYISGSYDVPRYTLHYKTDVPLSIRALLYFPEGKPGLFEMSRETESGIALYTKKILIKNRTDNILPKWLRFVKGVVDSEDIPLNLSRELLQNSALIGKLRDVLTARVLKFLQEQLKKNPEEYEKFYKDYGLFIKEGIITNYNMTEKESAANLLLFESSHEAPEKKVTLNDYLARATDNRTIYYLAAPSRTLAENSPYYESLKSRKQEVLFCYEPYDELVLMQLQQFKGNKLVSVEKDMREDKNANDLTNLGDDSLKRSEINDLSAWIKEKLGDKVAAVTATSRLESHPCVVTVEEMAAARHFIRTQSHSVSEDRRYAILQPKFEINPKHPIIKKMYTLMGTNPVLGELLAKQLFANSMVGAGLVEDPRTLLTSMNDLLVKALEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKA6</accession>
    <name>A0ABM5KKA6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510637.1">
        <property type="nucleotide sequence ID" value="XM_050654680.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654680.1">
        <property type="protein sequence ID" value="XP_050510637.1"/>
        <property type="gene ID" value="LOC126887265"/>
    </dbReference>
    <dbReference type="GeneID" id="126887265"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="462" mass="53455" checksum="E5085F921E22F4EF" modified="2025-10-08" version="1">MMKTPEHSSHEEEDLGRYIEERTLSKNMKVQAGNGPYTCAICLTPFTAACTLKSHMMTHTGERPYKCDTCLKQFTAPSVLKRHLRIHTGEKPYKCEICLKQFTEASYLKSHMMTHTGEKSYKCDICLKQFTHAGNLKLHIMTHTGEKPYKCDTCLKQFTAPSVLKRHLRIHTEEKPYKCEICLKQFTEASYLKSHMMTHTGEKSYKCDICLKQFTHAGNLKLHIMTHTGEKPYKCDICFKQFTHANIVKSHMMTHTGEKPYKCEICLKRFTQAGHFKSHIMTHTGVNPHRCEICLKQFTAASALKSHMMTHTGEKPYKCKICFKQFSQAGHLKLHMMTHTGDKPYKCEICLKQFTQAGPLRSHMMTHTGENAYKCEICLKQFTQAGHLKSHMMTHTGEKPYRCYICLKHFTQASNLKAHLRTHTREKPYRCEICFKQLTRADHLKSHMMTHTGNSLTDVKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMB3</accession>
    <name>A0ABM5KMB3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050511335.1">
        <property type="nucleotide sequence ID" value="XM_050655378.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655378.1">
        <property type="protein sequence ID" value="XP_050511335.1"/>
        <property type="gene ID" value="LOC114328880"/>
    </dbReference>
    <dbReference type="GeneID" id="114328880"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF285">
        <property type="entry name" value="V-MOS MOLONEY MURINE SARCOMA VIRAL ONCO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="184" mass="21120" checksum="8A060073A86537A6" modified="2025-10-08" version="1">MGKGSFGKVFKAQYKGKTVAMKLVKSNSYHREKNSLHLNHTNIVKTLEIIQRKNGIYSLIIMEYLPKSSNLQNVINNSKFDIDYLKYSQDICKGLEYCHSNGILHLDIKPGNIVVHEGICKLCDFGNSFDISDNMSYINQVVKCNLRPDLKEPVDSFSKLYQQCWDQNPNNRPNVANVLKMLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KN33</accession>
    <name>A0ABM5KN33_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498814.1">
        <property type="nucleotide sequence ID" value="XM_050642857.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511583.1">
        <property type="nucleotide sequence ID" value="XM_050655626.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642857.1">
        <property type="protein sequence ID" value="XP_050498814.1"/>
        <property type="gene ID" value="LOC126879669"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655626.1">
        <property type="protein sequence ID" value="XP_050511583.1"/>
        <property type="gene ID" value="LOC126887798"/>
    </dbReference>
    <dbReference type="GeneID" id="126879669"/>
    <dbReference type="GeneID" id="126887798"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="468" mass="52551" checksum="958BDFA575B383FF" modified="2025-10-08" version="1">MCTFQPEHLLVKELDYELRIREIEVEEAAKCDRKRSLLRGALKQEQGNRSFRQISAAAIPFLEQQQGINETLEDLTQKINNFRGTVHDSMYSRYISRLAHISGRVHLLCCSDEEQQLYKRSMSIRILSLEGELDSRVNPLATSTPVSSVQASNSLLHPKPVQVHKWGVSFSGEGHYDQVISFLDRVECLRVSRGVSEEDLFSASAELFTGHAFTWFMNNRGSFTTWTGLAQKLKSDFLPYSFQTDLLDEIKNHKQKPGESVTMFINTMLGMCSRLDTPLTDSSKIKIILKCLLPFYHAQLALVDIASIEELTEKCKRLEETLSWSFNPPTTSRFNSGPGFNSHSSRNRSWQSRPHTPNVSVATSSFSCWNCQEAGHAFRDCSRPQTRIFCHGCGKDNTLKRNCFKCSGNEHAEARTLSVPQTAAPSGNMTAAVDEASGPIPASSSNTSQEGRTTSNRRPTRKPKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNP0</accession>
    <name>A0ABM5KNP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050511812.1">
        <property type="nucleotide sequence ID" value="XM_050655855.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655855.1">
        <property type="protein sequence ID" value="XP_050511812.1"/>
        <property type="gene ID" value="LOC114326241"/>
    </dbReference>
    <dbReference type="GeneID" id="114326241"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="373" mass="43632" checksum="1947ABFE3642889E" modified="2025-10-08" version="1">MLAMDMEFKAEIKEELVEYNQTDMESQLSTSIDLETFKNELMEDNSPEMGLKAEIKEELAEEDHLFTSPDLEDSVNKADEDNSGFLENGMDIMKTELACTTQQQISANTEEITSKNSICKCEICFKQFNKAGSLKRHIKTHTAEKLYKCEICLKQFSQATSLKAHLRVHTGEKPHKCEICFKQFTDKSNFHQHMKVHTGEKPYKCEICFKRFSQKGNLNGHLRLHTGETPYKCEICFKQFNQKIRLKTHFRSHTGETPYKCEICFKQFSHKGYLNDHLRLHTGETPYKCEICFKQFNQKITLKTHFRSHTAETPYKCEICFKQFSHAHSLKYHLRGHTGEKPEKCEICFKQFTRPYSLKRHLRVHTGKTALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS10</accession>
    <name>A0ABM5KS10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512976.1">
        <property type="nucleotide sequence ID" value="XM_050657019.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050512976.1"/>
        <property type="gene ID" value="LOC126888657"/>
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    <dbReference type="GeneID" id="126888657"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="111694" checksum="CC3D1BAA012946CF" modified="2025-10-08" version="1">MALELETKRRTVLRTAFTTAANVLDNLLSETVDTRPWQQISVQWEMLQVKYNELCVVESAVFEAMVEKASEAELISEMEAKDRYSTRYYELKYKCEDRPSLVSSESSIEGKRSFKLPPIEFKKYSGDLIDWLPFWSQFKVVHDDPSIDLNDKIAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEEYAEVSTLETRLSGLMSFLQNEVQNEQKINLAMEGFGLSTENKCKSNNLVEKKNIKLPKQGTDQPSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKNCRARLNCILCCKFHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLWELDIIGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGWESSGEGMMGLLACPLEIETIRMYCSFKECVDIGYYVFKSVEFVTFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUF6</accession>
    <name>A0ABM5KUF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513823.1">
        <property type="nucleotide sequence ID" value="XM_050657866.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657866.1">
        <property type="protein sequence ID" value="XP_050513823.1"/>
        <property type="gene ID" value="LOC126889525"/>
    </dbReference>
    <dbReference type="GeneID" id="126889525"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="381" mass="43697" checksum="4D5081A52484C164" modified="2025-10-08" version="1">MGESAVQDNNATIYEGTFLSLNNDSSLNNVSDGVIERFENDPYLLPHWVLGLYFGFILIGSIADVIYVLALSRCKRNGTFSLLLQLTAVDAVSPVLAMIEILTINNQTWIFSHNLCPMYNGTEILVNSLQLWIIICINFHVISLWNLFKYESKRTKNPLVSCDDESNECLVTKRESTRVISIDYRRRKVDISVVIPSILIWFFCISLSIPSYTLSSSVKVKDNYVVCALLGSYYIQMFQILLLVFRVLLPIPLLLFSLIFLILKLSKTSLKDVKQILTKDFGELRVLLIFCICLTILYLATSFQRSLIHFWQINSQGFYSDITERFNVSSLYNNHLNISNNMSLTMLHYSCNTLRCALLLYLLPKFKEVLNNRVLSCHKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV99</accession>
    <name>A0ABM5KV99_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514116.1">
        <property type="nucleotide sequence ID" value="XM_050658159.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658159.1">
        <property type="protein sequence ID" value="XP_050514116.1"/>
        <property type="gene ID" value="LOC126889656"/>
    </dbReference>
    <dbReference type="GeneID" id="126889656"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="507" mass="59017" checksum="70BD222D3DF24DD0" modified="2025-10-08" version="1">MDIKQETSEETCKMKTDNETCDGPLDAFKIEIKQEPKTETEYQEFDYVDPNEFYVKVEAEQDEYKCTLFEEQQTTNEGSCSKENDMEILPAHSSQKENYTGQHAEEKILNKNVEVVTGQRAYKCEICLKTFTFNSALKVHLITHTEEKPHKCEICFKQFRKVSHLNIHLRIHTGDKPHQCEICLKQFGEASQLKKHLRVHTGEKPFKCKICFKQFGLAGGLKTHLRTHTGEKPHQCEICLKQFSEVSQLKKHLRVHTEENPHQCEVCSKQFSEASQLKKHLRVHTGEKPYKCEICFKQFAAASYMKSHLRVHTGQKPHQCEVCSKQFSEASKLKSHLRLHTGEKPYKCEVCSKQFSEASDLKKHLRRHTGEKPYQCEICLKQYSVASHLKKHLRVHTGEKPFKCEICFKQFIQASTLKSHLRVHTGEKPHQCEICLKKFAGDLKIHLRTHTGEKPHKCEICFKQFSQAGTLKIHLRVHTGEKPFKCEICFKQFSDAGNWKRHLRTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVW1</accession>
    <name>A0ABM5KVW1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma-secretase subunit Aph-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514325.1">
        <property type="nucleotide sequence ID" value="XM_050658368.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658368.1">
        <property type="protein sequence ID" value="XP_050514325.1"/>
        <property type="gene ID" value="LOC126889779"/>
    </dbReference>
    <dbReference type="GeneID" id="126889779"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26786" checksum="3F4891864FE39C82" modified="2025-10-08" version="1">MTVAEFFGCTFMAFGPPFAMFIFTIAHDPIRIIILIAAAFFWLVSLLLSSIIWSAIPLKTHLEFAIFYTVLFQEGFRFAIYKILRKAENGLKKITDNSTTLIENKHILAYVSGLGFGIMSGAFSLVNVLADAVGPGTMGLKAGKETFFITSSLIGLCFILLHTFWSVIFFYACDNRNYLHLGYVVISHLVASYLTLLNSHYEYWGSITTLYVILMFTGCAAFKVAGGTVASLVNGLNFKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWU4</accession>
    <name>A0ABM5KWU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514659.1">
        <property type="nucleotide sequence ID" value="XM_050658702.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658702.1">
        <property type="protein sequence ID" value="XP_050514659.1"/>
        <property type="gene ID" value="LOC126889947"/>
    </dbReference>
    <dbReference type="GeneID" id="126889947"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="2132"/>
            <end position="2263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2364" mass="276097" checksum="86B12D075375A4B2" modified="2025-10-08" version="1">MSLPPYLLGPNPWATMMAQQHLAAAHAQAQAAAAQAHAHALQQQMPPPHPKPDIITEDKLQEKALKWHQLQSKRFADKRKLGFVEAQKEDMPPEHIRKIIRDHGDMSSRKYRHDKRVYLGALKYMPHAVMKLLENMPMPWEQIRDVKVLYHITGAITFVNEIPWVCEPIYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNVLDVEPLEAIQIELDADEDSAIAKWFYDHKPLVGTKYVNGLTYRKWNLSLPIMATLYRLANQLLTDLVDDNYFYLFDTKSFFTAKALNMAIPGGPKFEPLIKDMNPADEDWNEFNDINKIIIRQPIRTEYRIAFPYLYNNMPHFVHLSWYHAPNVVYIKTEDPDLPAFYFDPLINPISHRHAVKSLEPLPDDDEEYILPEFVQPFLQETPLYTDNTANGISLLWAPRPFNMRSGRCRRAIDVPLVKPWYMEHCPPGQPVKVRVSYQKLLKYYVLNALKHRPPKAQKKRYLFRSFKSTKFFQTTTLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIIDSHVQYRLNNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMHDIVDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPIPIENMILRYVKMKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFAPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLIPVYDVEPLEKITDAYLDQYLWYEADKRRLFPPWIKPADTEPPPLLVYKWCQGINNLQDVWDVNEGECNVLLESKFEKLYEKIDLTLLNRLLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFITQYYGLVLDLLVLGLQRASEMAGPPQMPNDFLTFQDVQSETCHPIRLYCRYVDRIHMFFRFSAEEAKDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSVTTIQWENSFVSVYSKDNPNLLFNMSGFECRILPKCRTQHEEFTHRDGVWNLQHEGSKERTAQCFLRVDDESMSRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGISHDEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKVHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFSAYKWNVSRPSLLADTKDTMDNTTTQKYWIDVQLRWGDYDSHDVERYARAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLHSAYGNWFPGCKPLIQQAMAKIMKANPALYVLRERIRKALQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKIEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNTERTKVILKPDKTTITELHHIWPTLSDDEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSAQRQQIAEIEKQTKEQSQLTATTTKTVNKHGDEIITSTTSNYETQTFSSKTEWRVRAISATNLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFVTISDLRAQICAFLYGVSPPDNPQVKELRCLVLAPQWGTHQTVHVPNTPPNHPFLKDMEPLGWIHTQPNELPQLSPQDITNHAKLMSDNTTWDGEKTIIITCSFTPGSCSLTAYKLTPSGFEWGRQNTDKGNNPKGYLPSHYEKVQMLLSDRFLGFFMVPAQGSWNYNFMGVRHDPSMKYELQLANPKEFYHEVHRPAHFLNFSALEDGDGAGADREDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXH8</accession>
    <name>A0ABM5KXH8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514903.1">
        <property type="nucleotide sequence ID" value="XM_050658946.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658946.1">
        <property type="protein sequence ID" value="XP_050514903.1"/>
        <property type="gene ID" value="LOC126890098"/>
    </dbReference>
    <dbReference type="GeneID" id="126890098"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="153" mass="18381" checksum="7A03F9189C982FC3" modified="2025-10-08" version="1">MTADVFEEYFEEIIEHEHIPPNSIIVLDNAPYHSRLVERLPTTAWKKQDVLDWLRNKSLPYKDGMVKAELLKIARQHKSKYKKYVVDKMAERRNITVPRLPPYHCEINAIELIWAQMKGYVARKNTSYKIQTVRELLYESLEYITKQNWREDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXN0</accession>
    <name>A0ABM5KXN0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502162.1">
        <property type="nucleotide sequence ID" value="XM_050646205.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514951.1">
        <property type="nucleotide sequence ID" value="XM_050658994.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646205.1">
        <property type="protein sequence ID" value="XP_050502162.1"/>
        <property type="gene ID" value="LOC126881736"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658994.1">
        <property type="protein sequence ID" value="XP_050514951.1"/>
        <property type="gene ID" value="LOC126890144"/>
    </dbReference>
    <dbReference type="GeneID" id="126881736"/>
    <dbReference type="GeneID" id="126890144"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="832" mass="96347" checksum="F38A9D1DC8FED9CC" modified="2025-10-08" version="1">MVHCAECKVNFSKTSNLRAHVNRKHPEKIDVLAPKVKGEHGTFVCEECRATFVKLGSLRTHIQQKHAEKFQELVPAKKKFHCKQCNEEFDMLKKLIMHRRSQHAVINKELKCPLCPFTGPTSKHLISHYQTGHSLTVASETLFFQTFEEFQVWKMATERQTFSSFVNMHGFKKGVNCKKIKYTCHRSGNIRTRGQHIRSLKTRGSNKINGYCPAEMCVTLEDTKCAVQFCNTHVGHKLKEDMGHLFLSTSDRQHIASKIAAKIPLQSILDEVRDSVTNCKLERTHLLTKKDLYNIERAFNLNRSAIRHANDAISVDAWVNELKVSGSILFYKPQGCLSNEYPQLKQEDFVLMIMTEGQKELLLRFGDDCICMDGTHGLNGYGFELHTILVLDDLREGYPSAFLISSRNDAELMKIFFLHVEEQIGKKIKPRVFMSDMAEAYYNAWLQVMHPAEFRLYCSWHVDRAWRKNLEKVVNKEKKILIYQMLRMLLQERDIETFNTLTQKFLEFCQGSPESVEFANYFQQHYVNKAEHWAYCFRLYSGLNTNMHIERMHRTIKHLYLNGKYVKRLDKAISAILKFVRDKIFERLIVVHKGKVCTKLSELRQRHKTSEMLDISKVEAIDDGWLVPSASRNEMYVVQEIQSECTCKLECSECGVCIHRYACTCVDCSIKWNMCKHVHLVCKFIQQNSTSICKEVLSDNMISDVNEVDKAEETANLVMALSTKKKESQIVFEEQKKLVQTIQELIFNTQTLEEIEAIKTIVAPIQPTLEAIRNNQAQRKSFPLPMIAPSNKNIEPQRRLFKTKKAPKTKKTLSVPSVDEMDTLARQLIHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY67</accession>
    <name>A0ABM5KY67_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mos1 transposase HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515138.1">
        <property type="nucleotide sequence ID" value="XM_050659181.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659181.1">
        <property type="protein sequence ID" value="XP_050515138.1"/>
        <property type="gene ID" value="LOC126890318"/>
    </dbReference>
    <dbReference type="GeneID" id="126890318"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041426">
        <property type="entry name" value="Mos1_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17906">
        <property type="entry name" value="HTH_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mos1 transposase HTH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="123" mass="14254" checksum="01750FBD0A57A603" modified="2025-10-08" version="1">MEKIKYRAVIEFLFFGGLKVKEIYERMLKVYKDSSPSISTVQRWVAEFKRGRTSLADDPRQDRPKTVTAPEIVAKIQDMVLQHRRVTERDLVEALGISLGSITNILTEVLGFRKLCSQWVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYR9</accession>
    <name>A0ABM5KYR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rootletin-like coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515327.1">
        <property type="nucleotide sequence ID" value="XM_050659370.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659370.1">
        <property type="protein sequence ID" value="XP_050515327.1"/>
        <property type="gene ID" value="LOC114347881"/>
    </dbReference>
    <dbReference type="GeneID" id="114347881"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="74"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1756"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1929"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="300"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="456"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1756"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1775"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1934"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1947"/>
            <end position="1956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1956" mass="227632" checksum="7E03DF279E6D9D60" modified="2025-10-08" version="1">MPRPTVKKPETPKMEGRRPPSLYRPKSRTDSSSGTGGRTDSGRLRGDGGGGSSDEDVMSKELRHRLQEEASLYRKRLDTYKQAQQNQAALVSRLQAKVLQYKKRCADLESQMDQNPIYPEQPSSLTPIYPISTHTPSSAVEQAQQHLREIREERISDLDTALQRLSEERRRADRLMQLNTSLREQLEESHSTNEALTADLQKLTNDWENLREEMLVKEDEWKDEEQAFNDYYSTEHNRLLNLWRDVVGIKRLYNEIHTNTERDLSKIRFDISGMGKEMVMACSRMDTNLFTENIFGGKEKHQLEQEVAEMQSQIDSLKLNLDTRSNEIVMKDEKIQLMERDLHSLKERCTEAEHSCGQVVKMQEEIDILQGALRDIAHALIQDAENKDIEMLQATHLHLSAGTPLPQKSPKRSARSMTSPAAFAESTISAVQAALHKYQSFIHELQVKLQSNKEQLLLVRKQYENSENSVAALEDRLKEVVAQLDASHAQCSQVVQDRDLLHKNLEAVKAEKNQLDRNRIELNGLVESLQQDYDRLQKANNKMQKEVDSLQEEKMFMQTEIDRMNQEADIREINLRGEEDRCSRMREELLTVREELHKLYLAHDMLEAQKLEADNLIASLEKTKADYEIQLDRALGERTDVHDSLVKKETIATNLELDKKKLLEDIRKLDDEKKLLQHQCNDHQSDIQSLRKELLQAEQQKLDIESDKVSLSEKCKFLEIDKEKIEMELNQVTRERNELSNQLSVLGRKRDGLNEELVRCRQRLEQANETNARVNRTLEDLVKECEEKQCTIDAMDKEMNRTLELLATTRTEKETLEAVLFDAQTNLEASEDKKAQLEKEQQELLIKQEKLKAQIAKVAKDLERSEKKFVEVKTSMTHAAGNKEVEFKQTVDKMKQQNEDMVKKLTEEKEKIRTSLEKRLQQSLHKLTNEKDAEIQQLMERMENLQSHIENLCQQHEELMLRAENDKQQALLIAHHDHQALHDRLEATRRELEDERDGAERLKREANSRFEQDRTNINKLKEELSKYKTRLEEAKVRTEEEINKLEQRIEEVKTERDNCQSEAENLKIQLQLCENKSEGVGNQLHETLRKLKEATNNQEKLSRTENNSESLRKELTDVRRLLADGNFEKEKYHNTNKELRDHIKKTESEKREQARQLEDAYKAISNLEDIKVSLENERNRLQNQIRNLETEQLQIEHKVQGLQEELQRTQAANSQQQTEEKELQARLLNEVEERERAHQEVHQCRKQISELERNLDHTRLDLNKTRSHYGQLEEQWHAREQDLLVHLEDSKSKEKRLEDQKHNLEVCLVDATQQIQELKAKLGGAEGRVRALENQLVHLDSAKREVDQKLSSIISTLRRIAGIQLDGSVTMPYRLLSPSRRWSPARSYDDGRDGTIDVDPEVVRKGVRSLMQQVAQIERERDDYKTQVQITKKQLQEAQEGMSKGDNKLTKVLQNVRSLQEEKSGLEAKLGQKNTELQAQNNALQKKSEEAKEMRERVVSLELSLSSGNEQRLQYEDKMDKMKGAIDRLEAEKRSLQEELNRTENRSTKLELQRMSAEGDLQRLQMMLQEKDANIQKLQEKCDRQSRTIASLEERCVSLKSTIDQMTLSLEKASVGESELKGEMQSLQRALMDSTSASHTGAERLKQLQKQLANSENERRVITERFESTQQNLAEMRRNNQILQDQVARLNNELANNEVQRSGLESQLRLAQWPSDTGVCSHHEEELKNQLHSVQRERNDLRTKIESLNNKVRQLETENRSLERQASKGTNIRSKSYERERPEKYESESLPGENRDLRLKISQLEAELSEKEAEIGRLRNQRQTLDSKFDRAEIERYRAAQLQAERLLEAREQSHRQQVARLENQITLLREQLNQEIKRRQQYVMRSSKAGREMQQLRQALGDSLRTVSQDPSLDALLLEHEARKLDNTLSNTASLPPALGLPSSSYRRATTPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L071</accession>
    <name>A0ABM5L071_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515830.1">
        <property type="nucleotide sequence ID" value="XM_050659873.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659873.1">
        <property type="protein sequence ID" value="XP_050515830.1"/>
        <property type="gene ID" value="LOC126890707"/>
    </dbReference>
    <dbReference type="GeneID" id="126890707"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="443" mass="51203" checksum="3BA7FBAD34383C11" modified="2025-10-08" version="1">MESKIEIKEEYLGSGQIHIENKLSTLIDPGHIKSGPEDNSVMAVKTEIKEEFGDGDPRYVESQESTSFDPEGFKNEPEFNSALTIKAGVKEEFLEGDLRYIERQPSTSLDLEGLKNESDDYNSDRAVKAEFKDEFVEDDPRYIENQPSTSHDFGDCETEDTSGILEENTHPPIEENSIKCACMQVQTDVKPYKCEICFKQFRQDCSLTRHLRVHTGEKPYKCEICFKGYSTAGDLKRHLRVHTGEKPYKCEVCFKQFSHADSLKTHLRGHTGEKPYQCEICCKTFIQANHLKRHLRVHTGEKPYKCEVCFKQFSHAGTLKTHLRGHTGEKPYKCEVCFKQFSHAGTLKTHLRGHTGEKLYKCEVCFKQFSHASTLKKHLRVHTEEKSYTCEICFKQFNQAINLKTHLRVHTGEKPYECEICMRQFNTASNLKRHLRVHTRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L123</accession>
    <name>A0ABM5L123_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516139.1">
        <property type="nucleotide sequence ID" value="XM_050660182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660182.1">
        <property type="protein sequence ID" value="XP_050516139.1"/>
        <property type="gene ID" value="LOC126891002"/>
    </dbReference>
    <dbReference type="GeneID" id="126891002"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="231" mass="25640" checksum="6744C75F8403AE96" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYIVANLDTAYILEVRDIIVSPPATERYGKLKSELIKRLNASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAPRAQISEASNALESTIEKLTAELAEMKIQPSSLSNAQAQANTYRRNHSNSRGRPYPRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L193</accession>
    <name>A0ABM5L193_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleic-acid-binding protein from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516208.1">
        <property type="nucleotide sequence ID" value="XM_050660251.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660251.1">
        <property type="protein sequence ID" value="XP_050516208.1"/>
        <property type="gene ID" value="LOC126891073"/>
    </dbReference>
    <dbReference type="GeneID" id="126891073"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25033" checksum="36EE337623775348" modified="2025-10-08" version="1">MYDLHCKFEVLQVTRLNRRQVDENGTQYIPTKTCVVSFKSQVLPKYITINKVLKEVEPYKQKVLLCFNCLRFGHTGGQCKSKARCDKCQESHNSKDCKKTDLTPKCFNCSGDHFTTNLSACQEFQRQKLIKDAMSSNNISYQDANKQFPSNSYAKVTSINTEQTTNLSCLKTFPPLNPNNYTPTQFPSNPINKMSTNNIFYNNNSNSTNSRTFKRQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1N8</accession>
    <name>A0ABM5L1N8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516356.1">
        <property type="nucleotide sequence ID" value="XM_050660399.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660399.1">
        <property type="protein sequence ID" value="XP_050516356.1"/>
        <property type="gene ID" value="LOC126891217"/>
    </dbReference>
    <dbReference type="GeneID" id="126891217"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="710" mass="82369" checksum="33948E20FB5899A5" modified="2025-10-08" version="1">MSIICIICEKAFSSQSTLNRHNKNIHGKNTNYAKSTFPTKFLCLQCNIYFNINHDLRTHLEQEHNHSTELEKLEFNNFPDFNEWLMQEEKLKNVRYCKIKGAKTNTCGDEEKCYYECVRSFRNYSIKKERIRNLKSQGSCKMPFSCTSQIVLTKHLISDKCFVLYYKTHYGHREEIEHLRLSQIDRQAVASKLILGVPPKSIVSSVRDNLGKKLQRFDIITAQDVRNVKNSFGIVSKEGCRHKDDATSVHFWVSECFQSGSSPVLFYKQQGLVIEDYPNLKIDDFCLIFMNTVQKEILLKFGSDLIAIDGTHGLNPYNFELTTILVTDEFNNGFPVAFMFTNRKDTSVYELFFIKVKEIAGIVNAKVFMSDITNTFYNAWCHVMSPAEKRLFCAWHVDRAWQTNLAKISNTEKKSYVYKMLKDLQSILDIDRFIKSANNFLQKLLGDADTHSFGVYFSENYCNNFQEWAYCCRKGCGVNTNMHIESFHKVLKYFYLDGKKVKRLDKSIHKLLEYVRDKTVERIIKLTRGKSDDSTITSRHRAALTTHFSVFQCENNIFKLESENNTETHYIEKQKTTNCCEVKCTLCKICIHSYKCTCLDYLIKTTICKHIHYFVLQDKSVINQNENTVSLASETEVKQLVSQISSKKNSEQTIRNQIKEKALHIVHLADSEKVNKEQLKIMLDHVNSAVSVSSIPQTNFNIENPTVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2F9</accession>
    <name>A0ABM5L2F9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516631.1">
        <property type="nucleotide sequence ID" value="XM_050660674.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660674.1">
        <property type="protein sequence ID" value="XP_050516631.1"/>
        <property type="gene ID" value="LOC126891493"/>
    </dbReference>
    <dbReference type="GeneID" id="126891493"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="476" mass="55843" checksum="A990151BFEAD224B" modified="2025-10-08" version="1">MEPLKKPKEQEKKEDDYRQKKQDEAKTNKNENGEELSHDGKMEEIEERKKFEEEMLKRHQNQPKINRSGPITHSTLLDNILEETNREEEEKEGDAEEREPSAEAIEVEGEENKREDQTETHWQKTGDSILQALLFDDEDYEAIQQSKKRKGDSLEENERLKKEKREETAEYPEETENERILRKLKQVLEILNNKGPIQGEHKIIARNLIGEIYNQNKTGLNQSKKTQAEEENIRCEQCKIKIEREKQRKETEKIIEVLNKGGDINDFNQIYEKRWEETVYEKTKWEQGGLQETIAKKECLIVTKTEIKEGGIESVIRTIREEVHEIIEGCQEGNVEYIENGNRSSMATVRREWYTYVAKIKDQGIYEVAEKALKQIKERKEPPEIIRVAINNEINKEKVRKALEFVGRREKITWEIIIRGEEMDKEVKNEQEESLLIKTGSKSYTDVLKEMNAKINIGKIGVKVDRLKKTEGGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L357</accession>
    <name>A0ABM5L357_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516873.1">
        <property type="nucleotide sequence ID" value="XM_050660916.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660916.1">
        <property type="protein sequence ID" value="XP_050516873.1"/>
        <property type="gene ID" value="LOC126891678"/>
    </dbReference>
    <dbReference type="GeneID" id="126891678"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="735" mass="86190" checksum="F00F4DBF4BE6A36D" modified="2025-10-08" version="1">MCSRSELILELAEKAYKNTETDISYRSFEGKHIAESIVEESKYKKANEDPGDHETDINPECFTVSLEENEANRNENEIIENESDEEPFHADSDTDPDYIPTEDKNIPEVIIEPNKNITEATTNRKRRSRGNIERVSRKRIRDVSEWADEKSKTSLNLGLEHENRKGIQIKGRQMGAPCANTCRLKCATKIAKEDRDLCFNEFWKLKDHTRKWDFIARHVRQVAKKQVTITAEQRSRRNYSREYYFYIRNEKQRVCKTMFLETLNVSETWITTALRKLKDGGSLEEDKRGKHTNRPHKLSPKLIDNVKNHINQFPVVPSHYTRKNTMKMYLEEGLTIQKMYRLYNEHCKKNNITTAATSRQYRDIFNEQFNIGFFKPKKDQCTVCSVFNMASDPEKAKLLEQYESHMKNKEVIRNLKDIDKQLALDDKSLCVACFDLQKVLATPLSNVSDFYYKSKYSTYNFTVYDVGNNQGYCYVWHEQVAKRGPNEIASCLWKFLDLKAQQSVKTIIFYSDYCGGQNRNRFVFSMFAFAAAHFHIDIVHRFLEKGHTQNEGDSMHAVIENAKKRQSVVYVPEQWVTLIRMAKTTGRVYDVTEISQDNFFNFKKLTDTENWKLDNEKKSIKVSKRREIKFSHEHQNSIMFKYEFDDGFRGCDIKLNRKCRGRPSTTIKFPPKLYDAPLPIEEKKLKGLLWLCNTGKIPTMYHGFYKNLNSKSYVPPKVELEVDSVESEEESDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5R8</accession>
    <name>A0ABM5L5R8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517782.1">
        <property type="nucleotide sequence ID" value="XM_050661825.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661825.1">
        <property type="protein sequence ID" value="XP_050517782.1"/>
        <property type="gene ID" value="LOC114333421"/>
    </dbReference>
    <dbReference type="GeneID" id="114333421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01258">
        <property type="entry name" value="PHsplit_syntrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041428">
        <property type="entry name" value="PHsplit_syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF12">
        <property type="entry name" value="IP02644P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18012">
        <property type="entry name" value="PH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="145"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="40897" checksum="2A0F9C0DFA1E13C0" modified="2025-10-08" version="1">MRIIDINYVSVHLHIELVKNFKANFIFSVKYLREVTPYFRKASIISEVGWELQRGFLSGVPPVVRSPQRADTRYLPLQLCHLARNFRYPDPEGRTLELHSPDAIHSCVLRAADPAEAVAWFNTLHSALSLLTTSALHDASRAIPDLRHIGWLLRRPRSETMSSSESSEDMDRWQSIFAAVTDSELRFYESAPWSGEAWRAPAEAYSLIATRLVGSGKRAELPEFSIRCATVEGVITHSLRAETHRDLAAWAKALVNGSHASAVTQRELVCRCVWKGRPAQLVIHYENGFTLLEAGTGSRTLWRYPFDRLRNSSDDGKRYLWLDFGAADEGDVELDMEGCPKPIVFILHNFLSAKIHRLGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L698</accession>
    <name>A0ABM5L698_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 36</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517964.1">
        <property type="nucleotide sequence ID" value="XM_050662007.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662007.1">
        <property type="protein sequence ID" value="XP_050517964.1"/>
        <property type="gene ID" value="LOC126892476"/>
    </dbReference>
    <dbReference type="GeneID" id="126892476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="685"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="99876" checksum="16DF47EF38F9DB31" modified="2025-10-08" version="1">MTGSKVFLPSRGLGYVSNHIPLQVRYIKSRQENLIITCVGKSFHTYGISHFGLLSVSGLHHDDINCMTADAYHVYTAVDNVIYAWRRGTELKHTYKGHKKKVRLMIPFGAHLISVDESNNVKIWDIKAETVYLELLFSLETFNISAILHPSTYINKILLASDTGGMQLWNINNAKIIHTFSSWKAGVSCLAQAPAIDVVAVGLVTGRIILHNLKYDENVMEFTQDWGIVTSISFRTDGNPIMATGSSCGHIVFWDLEERKVSTQLLAAHDGSVTGMVCLSNEPLVITSSPDNTLKLWIFDMTDGGARLLRIREGHSSAPSHIRFHGSNGHNILSCAGDSTLRIFNTQTEQFNKSLGKASYNRKVSKKRGRAVEDPLKMPPIIQFTSETTREKEWDNIAAIHSNIPLVTTWSYDKIRMGQLKLLPERFQKKNKDVNLEVAASFLCLSHCGNFVIVGYTTGHVDRFNMQSGIWRDSYGNPKAHKYPIRGISSDTLNQFVVTGGGNEVKFWRFKNKDSPPLAVIPLEETINFFRSHRESSMLAIAMEDYSLNIMDIDTKRIVRKFTGHTAQLTDATFSPDSRWLITASMDCSVRTWDIPSGQMVDEFATDAACISLDMSPTGECLITAHVDYLGIFLWTNKTLYTRITLKSITPSDSPPLIMLPECGQDYTEDEEEIKEDVEEFVSPEQISKELITLSGLSTSRWQNLLNLDVIKQRNKPKEPPKAPKAAPFFLPTVASLSGIQFDVRPETEEQTKFTTPLSFVNLTDFGKLLETSKTTDIFNPVIDKLKKLGPSMIDFEIKSLSPDNGGTLEVMLQFLKCVEYMLKSNKDFELAEAYLSVFLKSHGLVIAQTKLLREYLPNVISCHQATWERLQDKLLYCTCVVQNLKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9F8</accession>
    <name>A0ABM5L9F8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Di19 zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519070.1">
        <property type="nucleotide sequence ID" value="XM_050663113.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663113.1">
        <property type="protein sequence ID" value="XP_050519070.1"/>
        <property type="gene ID" value="LOC126893163"/>
    </dbReference>
    <dbReference type="GeneID" id="126893163"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008598">
        <property type="entry name" value="Di19_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05605">
        <property type="entry name" value="zf-Di19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Di19 zinc-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="133" mass="14367" checksum="B768740E71D4B7A7" modified="2025-10-08" version="1">MGFTDVTLQEHVTADHQDINFEVVCPLCAAIPGGDPNLMTDDFSGHLTLEHRTGARDLISFLDEPVGTRHNVRHISHNTSHGTTHLGRGSTTASRARRSNMHFGSGGLSSSSPSSRDSVDPMAEPLASTYNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3F5</accession>
    <name>A0A6P7F3F5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase RNF10</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING finger protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114325949</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNF10 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028129906.1">
        <property type="nucleotide sequence ID" value="XM_028274105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3F5"/>
    <dbReference type="FunCoup" id="A0A6P7F3F5">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274105.2">
        <property type="protein sequence ID" value="XP_028129906.1"/>
        <property type="gene ID" value="LOC114325949"/>
    </dbReference>
    <dbReference type="GeneID" id="114325949"/>
    <dbReference type="KEGG" id="dvv:114325949"/>
    <dbReference type="InParanoid" id="A0A6P7F3F5"/>
    <dbReference type="OrthoDB" id="10064108at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000112">
        <property type="entry name" value="RING finger protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="630"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028129906.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="79116" checksum="499608ACDAE8DB06" modified="2020-12-02" version="1">MEKKGNRNLPLAKGSTTDSKKDGISSKPWPRGSRRRECAGSSLSSKPEVSRKPQPQRVKTFDKRPRPRGGGLCGTLARNETPSLEDTDDHQQVELGSVFLPGSKKQSLNHLLNFSYSPRDSFHRSERGQGNGNNVNRMMGTKKHKYNKEHFLQANCQFVVNDSGDYKQYLNNPDALVDWSLVEQVNIQVSEFPTCPICLYPPVAAKMTRCGHIYCWSCVLHYLSLSDKPSRKCPICFENIQKQDMKSVVAIPYTSFNTDETITFKLMKRPRGCLIAYPADAETKNENDIFNMSDQGSRDVYSKLLLAKTDDVLTIIEREFNELKEELKDDISPERCFIEQAMVLLKERESVVCGHVIKNDHSLEPSEENQLVDSLKEVEISGDDQYKQITDEILEDCSSIQPAKFHYFYQASDNQHIYLHAINARMLEHSYGSLEFGPKTITGKILEKEGGSMTEELRKRLRYLQHLPVTCQFEVAEIQLKTPVVNKDTLEHFRDQIEIRRKRRQKRAKEEKRREKRIEVEENRKMGKYLHPNLHLDSNIQFPEFGFETRLRSESESTIPSERSASPDLAGTPTSVSLEGAYSGPSFAKMLATEKKSSPSWPGLKATSSTSKSPDLINVTGSKMKMLSTVRVPSDNEQDPDGYEPVPSFNRSFGDAIAKALEQAEKPEEESIQSSGKKKKKSKQKVLFATNMAYSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4H7</accession>
    <name>A0A6P7F4H7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endothelial lipase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114325848</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129782.1">
        <property type="nucleotide sequence ID" value="XM_028273981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4H7"/>
    <dbReference type="FunCoup" id="A0A6P7F4H7">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273981.1">
        <property type="protein sequence ID" value="XP_028129782.1"/>
        <property type="gene ID" value="LOC114325848"/>
    </dbReference>
    <dbReference type="GeneID" id="114325848"/>
    <dbReference type="KEGG" id="dvv:114325848"/>
    <dbReference type="InParanoid" id="A0A6P7F4H7"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000076">
        <property type="entry name" value="phospholipase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF190">
        <property type="entry name" value="VITELLOGENIN-3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028189416" evidence="5">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028129782.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36761" checksum="73E5D5C945321086" modified="2020-12-02" version="1">MKYCKIYISLLLLGACHLLTGDDEHSEDLEYFLYEDKDGNLQVEYLLNNTELKLTSSASDVKYLFFSKSNPDSGVEIHSNNVEKLATTSFTARRETIFVIHGWKGSHEADINSHVREYILRDHDVNIFVVDWSPIAGRSYTTAQGSVKQVGEYVADFARSLNQKYSLRLDKLKFVGHSLGAHVCGNAGAALNGQVDRIVGLDPAGPLFKDNNKDNRIDEDDAVNVQIIHTNGGLLGYYAPCGDSDFYPNGGKSQPGCGIDLTGSCAHSRAYELYAESLTSKAFVGQRCDSYSDYEKDRCDGPKTSMGMFQIDKDASGSYYLKTNKRSPYAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5J0</accession>
    <name>A0A6P7F5J0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114324988</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028128720.1">
        <property type="nucleotide sequence ID" value="XM_028272919.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F5J0">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272919.2">
        <property type="protein sequence ID" value="XP_028128720.1"/>
        <property type="gene ID" value="LOC114324988"/>
    </dbReference>
    <dbReference type="GeneID" id="114324988"/>
    <dbReference type="KEGG" id="dvv:114324988"/>
    <dbReference type="CTD" id="39443"/>
    <dbReference type="InParanoid" id="A0A6P7F5J0"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005001">
        <property type="term" value="F:transmembrane receptor protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000092">
        <property type="entry name" value="Tyrosine-protein phosphatase 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF495">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 69D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="240"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="345"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="445"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="839"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1020"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1132"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1332"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028128720.1"/>
        </source>
    </evidence>
    <sequence length="1426" mass="163320" checksum="3D0DCA5AC0A9F964" modified="2020-12-02" version="1">MICQAHYPYVFLLFYLFLTYGIVTSNPIDEEDKELNITVEVLKHELPNQLPLGDNITIICKTKWMSSEMMWTFNDTNVSDLPGFKLEMESENINKESGNKFEVSILHIISIDFNHVGNYKCHAMIRNETTPDIDFRQIFLNVTLPSKIVQISKPAYTKIHDTVELFSVVQGYPIEEIRWLKDNELLTDFKWDVKDINITHKNTSLKFEVSKKDNGTYTVVVITPTSQAKNFTDVLVLDKPQVTLDFIKPIGINKIYFNWTVNDGNSPDDLKYIIQYKSEEDKEWVYYQANVNATSTSLVVTVRNNSGTPNKNSSYTVRIMAKNSQGESMYSTSNLVKLLDEEPIVVPEVTVTGVTSSSITIKWTPPPEKFKDHIHYYQLILKSYNTPEKFEAVQPAIKDYLYMFSDLTSATTYNFQVAACNDYSKECGPLSEIVNGTTMDGIAGPPSHASVECRFDNISHTNFVFVSWQPPAEPHGTITSYSVTLEGSAVFLNDQGQSENITWGPKSTSIGEMTLNTRFYNVSANTNYTVRISGVTRLRKNGQLVTLNCTMPPTLPDKQKLARLHWKKMEEQGKWMFKLFVPRVSERNGPICCYRIYLVRMESQQKLSDLANPEDLTIMTYQEAHRTPRGGAYVAEMFTSSSFHNEIFLGDEQVYNSSSSQCDECIGLRPFNTPREEKIKNSTNLANRVRRNEVLLDPFPPCDGTLDINSNYTGFVEVIVHGESQPLFLAAYSNYLDMMNPGPEVVAAPTTGTLSLIVQILCALVVVILILLGALCILHRYTKQAHAQAVEMITFRTSLRSLRGRQRLVSLNPPDMCPISKADLVSAYIEHHRDSDYGFQQEFELLPDRFSDRTTRASDARENVYKNRYPDIKSYDQTRVKLSQVDSIAGSDYINANYVMGYKERKKFICAQGPMDTTVTEFWRMIWEQHLELILMLTNLEEYSKTKCSKYWPDKTDGDKIFGDITVAHLQETRYSDYIVRELKILRSSHGKELEERNITQYHYLVWKDFMAPEHPNGIIKFIKRVNEAYSVEKGSILVHCSAGVGRTGTLVALDCLLHQLKEEGHVSIFNTICDLRHQRNFLVQSLKQYIFIYRALMEVAQYGDTEINANELKNTLDKLRQCDNGKTKCRLEEEFENIIHAFEDRKSCSVASGEENREKNRCDSIIPYDRNRVILTPLSGKEHSTYINASFIEGYDNSESFIITQDPLEGTINDFWRMVSEQGISVIVMISEVGEGKCPRYWPEEEAHYDHIHVRYVQAESCPYYTRREMIIKSRDGEDQKVTHLQYHGWPTVDGENLSRLLLPPIFTINFTFLQQGASIETSFQVPEVTRGLIELVDFSQAVLVKNGCSPSMVVHCNLGSDRSSMFVGLSILVQQLRTERRVDVFTITRKLRSQRQAMINSYAQYEFLHRAIVNYAELHGLCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8E3</accession>
    <name>A0A6P7F8E3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114326000</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114326000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129963.1">
        <property type="nucleotide sequence ID" value="XM_028274162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8E3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274162.1">
        <property type="protein sequence ID" value="XP_028129963.1"/>
        <property type="gene ID" value="LOC114326000"/>
    </dbReference>
    <dbReference type="GeneID" id="114326000"/>
    <dbReference type="KEGG" id="dvv:114326000"/>
    <dbReference type="InParanoid" id="A0A6P7F8E3"/>
    <dbReference type="OrthoDB" id="7752123at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028129963.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24326" checksum="671734F7D241699C" modified="2020-12-02" version="1">MGEKTSKDEIQDNGVVNSNFVVTNKDIRPDAELKILLYIITAVLINRVSPPTEAVMVPMEGKQEKYEEKHTLWDTSEIDNEFRCLSEISLKCTGKVYKNVTLTSYYPDYNDQDHEHGYQDKQGKKLRTLQDYIDNRADFVTLAMDEIIGIPYGTKVCIPELNQHFGHRILIEVRDTSYDLSGSGFTRADICVRSEVDSYDKSVNRLVNLVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9X7</accession>
    <name>A0A6P7F9X7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDK5 regulatory subunit-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114327254</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131597.1">
        <property type="nucleotide sequence ID" value="XM_028275796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9X7"/>
    <dbReference type="FunCoup" id="A0A6P7F9X7">
        <property type="interactions" value="1612"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275796.2">
        <property type="protein sequence ID" value="XP_028131597.1"/>
        <property type="gene ID" value="LOC114327254"/>
    </dbReference>
    <dbReference type="GeneID" id="114327254"/>
    <dbReference type="KEGG" id="dvv:114327254"/>
    <dbReference type="InParanoid" id="A0A6P7F9X7"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028131597.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58820" checksum="4DEEED5F80E7442F" modified="2020-12-02" version="1">MMDEQNIPIDINTTKLLEWLISRRHVKTDWQNSILKIREKINNAIQDMPAHEGIIKLLSGQHINYFHCLKIVEILKETEADSKNLFGRYGSQRMKDWQDIVTSYQKDNVYVAEVSQMLIRNVSFEIPSLRKQVSKLEQSQLECEKKIKDYSRAESTAQKEFKNSCDQLGISGKKIKSEIIDLLKDLPGTYKTISEKIKIVAPAVELYNAFNKYLSGKKIDESALPLLEYLIKHGNTTTYEYIYGEKPVSIEESTPDISEDKSSSDSDKIDFGDIDFGDNGGEINFDINTDNGTIDFGDVIEESQNIDWGASNPEEGFEIVTHADLDINLEESGIVVEKTGIDGGVAKGEEALTILDNPKTQEQVINSLMELSAFIKMRLYEMMNDTDMLSTSQMQDAPTIIQMQTVESITMLNDYISIALDQLTNKKIQHLHNIKHSPRYVDILTANLNQKLAIVDKMKANKAILEDKIKTLREEAGSIEPIIKLLIEKTKQLQKEIQDDISKKYKGRTVNIIGGVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDY0</accession>
    <name>A0A6P7FDY0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein mab-21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328406</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133052.1">
        <property type="nucleotide sequence ID" value="XM_028277251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDY0"/>
    <dbReference type="FunCoup" id="A0A6P7FDY0">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656670.1">
        <property type="protein sequence ID" value="XP_050512627.1"/>
        <property type="gene ID" value="LOC126888419"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FDY0"/>
    <dbReference type="OrthoDB" id="5961151at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000002">
        <property type="entry name" value="protein mab-21-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.90:FF:000001">
        <property type="entry name" value="protein mab-21-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF70">
        <property type="entry name" value="PROTEIN MAB-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028133052.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41688" checksum="E7E2766D97F5E973" modified="2020-12-02" version="1">MLVPADMLAAQSKMLYQINKYYGERVQTRMATIAKTIREVCKVVQEVLKEVEVQEPRFISSLTECNGKYEGLEVISPVEFEVVLYLNQMGVFNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQACDKCSYRDSVKMIADTSEVKLRIRERYIVQITPAFKCSGVWPRSGSHWPSPHIPWPHPNLVAEVKTEGFDLLSKESIAAQGKQTSMEGDAWVLSFLEAENRLLQGGCRRRCLSILKTLRDRHLDLPGNPVSSYHLKTLLLYECEKHPRESEWDESCIADRINGIFLQLISCLQCKRCPHYFLPNLDLFKGKSPSALENAAKQVWRLTREMLTNTRCLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FF08</accession>
    <name>A0A6P7FF08_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114327489</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028131930.1">
        <property type="nucleotide sequence ID" value="XM_028276129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FF08"/>
    <dbReference type="FunCoup" id="A0A6P7FF08">
        <property type="interactions" value="1502"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276129.2">
        <property type="protein sequence ID" value="XP_028131930.1"/>
        <property type="gene ID" value="LOC114327489"/>
    </dbReference>
    <dbReference type="GeneID" id="114327489"/>
    <dbReference type="KEGG" id="dvv:114327489"/>
    <dbReference type="CTD" id="44291"/>
    <dbReference type="InParanoid" id="A0A6P7FF08"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="93"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028131930.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46037" checksum="E85D630512E9BDE0" modified="2020-12-02" version="1">MGKIKAGTVVDILGDEMTRIIWDAIKEKLILPYLDIDLKVYDLGIENRDKTNDQVTIDCAEAIKKYNVGIKCATITPDENRVIEFKLKQMWKSPNGTIRNILGGTVFREPIICKNIPRLVRGWDNPIIIGRHAHADQYKATDVIIPSAGKLELIFTGASGDTQKYVVHDYKGPGVAMGMFNTDDSIVAFAHSSFKYALERGYPLYLSTKNTILKKYDGRFKDIFQDIYDREYKSSYEAKKIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLISPDGKTVEAEAAHGTVTRHFRMHQQGKETSTNPIASIFAWTRGLLHRAKLDNNQELNKFAHALEQVCVETIESGSMTKDLAICIKGMSKVTREDYLETFEFINKLAENLKKKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGN7</accession>
    <name>A0A6P7FGN7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-tocopherol transfer protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327841</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132348.1">
        <property type="nucleotide sequence ID" value="XM_028276547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276547.2">
        <property type="protein sequence ID" value="XP_028132348.1"/>
        <property type="gene ID" value="LOC114327841"/>
    </dbReference>
    <dbReference type="GeneID" id="114327841"/>
    <dbReference type="KEGG" id="dvv:114327841"/>
    <dbReference type="InParanoid" id="A0A6P7FGN7"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF226">
        <property type="entry name" value="CLAVESIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="84"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132348.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="32343" checksum="C745BF6C4461BE47" modified="2020-12-02" version="1">MPSNSKKEIPPLTEDQQHAIKSLRKRIEDELNHIKNINTKDTYLLRFLYCTDFNTELGFKKIKDYYENILAYPKWYSTDPPIKIKPLIDKNISVMVPASVDKDDRQIYLFKVGNVDIQNISIQEISFLDDIWFEYLLENEPHLSGKGICIIVDFEYVTWKFAKWFNYRNVKIGFKKLALVPFKEIKIHFVNNSKSMKYFLKLIVSCVPEDIKKQVHFHFSDQETLAKHIDKDFLLPEHGGYNKLNYTRIYKSLFEINDIIASNLNMNKNDRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FML1</accession>
    <name>A0A6P7FML1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114331850 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114331850</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137331.1">
        <property type="nucleotide sequence ID" value="XM_028281530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FML1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281530.2">
        <property type="protein sequence ID" value="XP_028137331.1"/>
        <property type="gene ID" value="LOC114331850"/>
    </dbReference>
    <dbReference type="GeneID" id="114331850"/>
    <dbReference type="KEGG" id="dvv:114331850"/>
    <dbReference type="InParanoid" id="A0A6P7FML1"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006970">
        <property type="entry name" value="PT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33683">
        <property type="entry name" value="1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33683:SF46">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04886">
        <property type="entry name" value="PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027835431" evidence="4">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028137331.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23345" checksum="E7E242608D6A7100" modified="2020-12-02" version="1">MKVTILFITSLCIYLAYAHQENPEKSTEKPTAKPTEKPTEKPTAKPTEKPTAKPTERPTEKPTEKPTTKPTEKPTEKPEEDNNQCLCENQLEDVYEEVYHLYEDICELSNEIDEIQKDLHDLDVKVCDQTPILRHLKLEILALKKNQTLTLTELKNQTNTLSIIVGNIKSVDHEIKKIKGHVNLQTTHIDYLKQILLHVKICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUZ6</accession>
    <name>A0A6P7FUZ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114332996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332996</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138602.1">
        <property type="nucleotide sequence ID" value="XM_028282801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUZ6"/>
    <dbReference type="FunCoup" id="A0A6P7FUZ6">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282801.2">
        <property type="protein sequence ID" value="XP_028138602.1"/>
        <property type="gene ID" value="LOC114332996"/>
    </dbReference>
    <dbReference type="GeneID" id="114332996"/>
    <dbReference type="KEGG" id="dvv:114332996"/>
    <dbReference type="InParanoid" id="A0A6P7FUZ6"/>
    <dbReference type="OrthoDB" id="6702328at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF2">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028161949" evidence="1">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138602.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16137" checksum="48A8C54DBAE906D3" modified="2020-12-02" version="1">MYRLILPVFVLFVTAKIAAHPLDLSDFKQEVIELTKVLHNECVGKTGVNEQIIDKAKEGVFEDDVKFKKYLSCCWVTSGVMEKSGKLNEDMLIGFIPPKYKTTIGKSVLTCQKNVAGIKPLHNMVFEMEKCIYAAAPELFVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW75</accession>
    <name>A0A6P7FW75_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fibrinogen-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114334777</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140671.1">
        <property type="nucleotide sequence ID" value="XM_028284870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW75"/>
    <dbReference type="FunCoup" id="A0A6P7FW75">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284870.2">
        <property type="protein sequence ID" value="XP_028140671.1"/>
        <property type="gene ID" value="LOC114334777"/>
    </dbReference>
    <dbReference type="GeneID" id="114334777"/>
    <dbReference type="KEGG" id="dvv:114334777"/>
    <dbReference type="InParanoid" id="A0A6P7FW75"/>
    <dbReference type="OrthoDB" id="10666173at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027774201" evidence="3">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="208"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028140671.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48775" checksum="DFCE918C7017406F" modified="2020-12-02" version="1">MISWVALLLICAKFAVGFHSPAEEVPAADPNNVKFRKCVDFTAEGGANSWKQDLKTFLYPENEAFDLGTKKDNDKFRMMSLAVVDKLNSLQEYANTVKNVSDKLNSLQEYENTLKNVSDRLNSLQQYENTLKNVLDKLNSLQEYENTLKPVFDKLNSLQEYENTLKHTFDKLSNVQEYQKKVFDKCKYLVGKSQIPFCGLNPEQPFSETEHAYPSSCKEILKGGKNKSGVYIIKPKRSGKSVAVLCDMETKGGGWTHIQKRFDGSQEFYLPWGDYKFGFGDLMGEFWIGLENIHLMTAFESSELLVELTDTDKKNYYAQYSSFSIGNEKDGYILNKIGGFSGDAGNSLIGHYNQKFTTFDVDQDQDSDGNCAQKREGAWWYNNCIDSNLNGKFMTEEKYSLRGLIWYSLKKYENLAGSRMMIRPFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXJ8</accession>
    <name>A0A6P7FXJ8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein croquemort-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114331819</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137285.1">
        <property type="nucleotide sequence ID" value="XM_028281484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXJ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281484.2">
        <property type="protein sequence ID" value="XP_028137285.1"/>
        <property type="gene ID" value="LOC114331819"/>
    </dbReference>
    <dbReference type="GeneID" id="114331819"/>
    <dbReference type="KEGG" id="dvv:114331819"/>
    <dbReference type="InParanoid" id="A0A6P7FXJ8"/>
    <dbReference type="OrthoDB" id="514335at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF93">
        <property type="entry name" value="GH07959P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028137285.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="57656" checksum="FC94E769B4D8EF5D" modified="2020-12-02" version="1">MKNSDVSRTPVMHQTKQCGRVCLLFTGIFLICFGSCIFIFFESIYDLLLNYNLRFEPGSLAYQGWERSPPVETNIYLFNWTNPEDIKNHSVKPEFEELGPYRFYEVKGKSNISFVDEHVNYKTYTSSFFDEKKEGRNLSDVINSINTVAVSIGYQARFQSYWTKKMISFGIGSRSAHLYVTKTVRELLFDGYDDPILGIISKIPFVGAPEKGGLFFGRNGTVGLDGTYSLNYKNDEHFGEVLLWDGKNETNFFSGECNAVKGSGGEFFPLNRKRDQIVMFSSDLCKSLVLRYVEDVTIKGVHGYKYSAEYGFDNGTVHPENACFCNGECIPTGVFNISSCRQGSPSFLSFPHFYNADPIYQNAVKGMKPNKTQHEFYMILEPKSGIVMEVQAGMQLNMLIQRVSSISLYDKLPKIFMPVFHITHKAELTDEIASGLRMLQSLPEYCNYFFYATLLLGCFCISFALFSLFCCNKDKEKNKYDIHPVKTSLYEQVPMNEKKADIVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXL7</accession>
    <name>A0A6P7FXL7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114333768</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139562.1">
        <property type="nucleotide sequence ID" value="XM_028283761.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FXL7">
        <property type="interactions" value="2259"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283761.2">
        <property type="protein sequence ID" value="XP_028139562.1"/>
        <property type="gene ID" value="LOC114333768"/>
    </dbReference>
    <dbReference type="GeneID" id="114333768"/>
    <dbReference type="KEGG" id="dvv:114333768"/>
    <dbReference type="CTD" id="42899"/>
    <dbReference type="InParanoid" id="A0A6P7FXL7"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
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    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
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        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
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    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="429"/>
            <end position="496"/>
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            <end position="585"/>
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        <location>
            <begin position="596"/>
            <end position="675"/>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="977"/>
            <end position="1145"/>
        </location>
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        <location>
            <begin position="1163"/>
            <end position="1199"/>
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        <location>
            <begin position="1313"/>
            <end position="1340"/>
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            <begin position="33"/>
            <end position="43"/>
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        <location>
            <begin position="1001"/>
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            <end position="1107"/>
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            <begin position="1163"/>
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            <dbReference type="ARBA" id="ARBA00004604"/>
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            <dbReference type="ARBA" id="ARBA00022517"/>
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            <dbReference type="ARBA" id="ARBA00022552"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00073619"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028139562.1"/>
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    </evidence>
    <sequence length="1482" mass="168728" checksum="7A58C9EEB5DE5683" modified="2020-12-02" version="1">MMDDEDFPRGGVRPKKALKRKDDDNLFSSAIKPKPKKAKKAKKTTQIESEDSFHSSLQISETLSYRTLQQDMIILACIKQIKDVSMDIELPGLTFGQIKIINISDSFTHYLQENNNEESITLVPQMFSVGQMIIVKVLSIENRDEGTHIQCTLNPKDINSGKYHNSFPEGLLVWASVTSELEHGYKMDIGVNNCRAFLPFKNVDKNRKLIIGQPLWCVVTKCDSSEAAATIQLSCRTDRLKKCKISEIDSLHNLIPGMQVDVMVETVRHTGLYGKFLNDFFAYIDEGQLEKSLSKYKEGNLLTAYVLYTNHVTKITYLTMFDMDKVPAPKYTEGDILVGEVISTARKGIYLSLPSKEKCFVTHKRLLLSFPKKYDDSDLTDMLKLKFVVGSRHSCRILAYSNVTRSYIGTLEQKMIREQYFTSADLKPGQLVEGVIVESNEKGLVVKVGRVRCFASNFYLSSVAYTENIKKKFKEGRTVKARVWDIKGNNVLLTLKSEQVLSDRCLTTVEDAKRGERYPCVIVKTYPNGAYVIFYSNISGWLPKKYLDEENENDKPDPQQLFFIGQVINPWILGVKEQRVILSLRPPKNFGFLKIGEKVNGVIGRITKDNLFIKTQIGKPVGVVPVNHLSETLSLCPTLINTFKVGDEINNLLCIDNTDNTNILSKRESLAITRTPKFRIKKLDKFKLRHLVRCTYLSQCDEGIYVRPCQISDYHERVLIKYKDILGKGVKIGVSLLPFEPNQVIVAKIKQIQENPKSISLTAKLADVFDNKVESVIGFFTQHLQDIQTIRTMGKEKKWDLYEYEPGETVLCRVTKLGDGGGCLVSLPNGLNALVPTALCTDVKIGDKLPGVFLTQNFDQKYGIVCLKPEISERINKNQDGIITCKNLSWCRSELLFIGKTFAIALLKQIGGNGQLVYLPTFLHENDFKGSCKSYYEEGSLRITLCGQLENYLIGMSRRQFLNLNKHSKPEQKYCVKTIPIREPSKEQNTIDDGKVHDVSDSDVEVVDQESSMEEDSGAYSENESDDSLEEADDDDSLEEADDDDEGDVQEEESDDELNQETDSFEDELELEDDSEDEDSSNNEDTESKGESINMTQHSDELDRSVEEVEINEEEDSSEKTNNTRTTNVKVQKKTIKKFSSSDSITGPLPVLSGMNSFFNEDVTEEPDVSSDDEVEETTVKKKKLSASERAQQAKEEEERIRQIEKELADPTKAPESAEHFDRLLLASPNSSKLWLQYMAFHVAATEFEKARAVAKRALENINYTYVDERFNIWITLLNFENTYGTNESFSKVFEEAVKCNDDLKIYLETIRILAESGQIAEMEEKIKKVRNKHKQNSHMWIEVAKIYYMLDKFKEARNLKDAALKSITIKKMQLDIIVQFALMEFNYGEPHYGSHIFEAILSSDPKKVTIWTMYVDQLVKKGKIDEARQVLDRSVSQHLPVKSLKSLFLKYKMFEETYGNPETVQEVKEKVKELMSKISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G127</accession>
    <name>A0A6P7G127_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114332399</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332399</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028282534.1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028425633" evidence="1">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138335.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23500" checksum="8C33A35ACA07798E" modified="2020-12-02" version="1">MDYHCLRQRNTKMKIVLLVLFAACLSQAKINQDIHFNWVQYTGEIPENAIIGGETGDSDPTYVARSVLSANPDDENYSGSDYNGYVAGGVLPGKLVMNASTPESIYTLTKNIEILTVVNGTKIEWIESFEHAFMEIFNSDDYRPVRIGWQANGDMWNSTLYLGSSFADGVIYIGHILTSAIPPGLNQNSYHPFYTNPFADGLYKVLVYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1X7</accession>
    <name>A0A6P7G1X7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="6" type="primary">LOC114333016</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
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    </dbReference>
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        <property type="protein sequence ID" value="XP_028138630.1"/>
        <property type="gene ID" value="LOC114333016"/>
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    <dbReference type="GeneID" id="114333016"/>
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    <dbReference type="InParanoid" id="A0A6P7G1X7"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000085">
        <property type="entry name" value="Glycogenin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="523"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
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        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
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        <location>
            <begin position="758"/>
            <end position="802"/>
        </location>
    </feature>
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        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
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        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1155"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028138630.1"/>
        </source>
    </evidence>
    <sequence length="1206" mass="132386" checksum="5F62F8F5EA98D74D" modified="2020-12-02" version="1">MGGGYAWVTLATNDSYSLGSLVLAHSLKQVGTKQQLAVLITPGVTNSMRSKLNEVFNVVKEVNILDSKDEANLRLLKRPELGITFTKLHCWRLTQFEKCVFLDADTLILENCDELFEREELSAAPDIGWPDCFNSGVFVYRPSNETYEKLIQFALDKGSFDGGDQGLLNLYFSDWAHKDISKHLPFIYNLASTACYSYLPAFKQFGKNAKIIHFIGASKPWLQYFNTETRKVHPSEGLQHLAIILQHWWDIFCNLIHPALTPDMTSHRHTVHGSQSYTSQSDSHTSYYYDHDHNPSVQNPQNAEDFQNVWDPWEEYDSRQSSNVVPQNITHEESHSQHYGQSHFEQTHHSDHGHDTHIHQSDHFVHTPPHMSEHHHQPAQNIDYSHHEQSHSHSHYVQPVYTENKQSETHFPDQSSSSSYVEYRPPEIHHYHHSESHYHHSENKPSESHYHHSENKSSESHYHHSVDHTPSEHHHHHHYEHKHESSHNYEHHTERRESSSQNQQNLIESHNTNTFSRADHNVHIHHPSIPTSSQPHSPNIHHQPPTCEYSSDHPPPNDPRLPDECVATTTVSNEITLKSDSNEENSNNQAGLAGAFANLTLGQPRTPEQQALDDHLRRQGWEVGNIDYLGRDSFDNIWSKICETLALAPDAESEPAASEEKPVEAVAEPEKSAETAPTVEQPQEAAPVVLSAAVEVSDSPQSKIESPTAVIPPPQTPQSVPSESKAPEPTEAAPKIPPVQSVPDQPESQQPVVEILSAGVAPPATGATPQPAGAAPPAAGAAPPAAVAVPPAAVAAPPAAVAIQQESPKSETPIQQPTLPGQESQQVPVETSQAVQPSEVKEPSTGAPSPATQTVEPVSTELPKVEPTVVPESPKQVPETQADLPKAVDSSKESTGTVTAQSVSEKPLTEPQTVVSQSPEKPEEQKPTTEDLKSPEVVSDSPQAATQEPVKEAPKDSTQEVQQETPKSPEEAKKVTPAESPKESQKEVLTQAPTEAPKEVPQVQPKAVVEAPKEPPKEAPKEAPKESPKEAPKESPKEAPKESPKDAPKETPAQKEAPKETPAQKEVRVSKESPKAAQKDAPKQSPKETQKDSPKESPKEPEKPAPKASTPKQSPASKKGKKDTPKEESKQKETAELPSSKVTEPTPPTTPVSPPVSQESSSPSPVSKAELQVSASVPETPPPAPSTEAAKGPTPPPRKSGGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3D9</accession>
    <name>A0A6P7G3D9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114335491</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028141532.1">
        <property type="nucleotide sequence ID" value="XM_028285731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3D9"/>
    <dbReference type="FunCoup" id="A0A6P7G3D9">
        <property type="interactions" value="1864"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285731.2">
        <property type="protein sequence ID" value="XP_028141532.1"/>
        <property type="gene ID" value="LOC114335491"/>
    </dbReference>
    <dbReference type="GeneID" id="114335491"/>
    <dbReference type="KEGG" id="dvv:114335491"/>
    <dbReference type="InParanoid" id="A0A6P7G3D9"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="235"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="612"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="792"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="726"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028141532.1"/>
        </source>
    </evidence>
    <sequence length="860" mass="98582" checksum="1670A3E6CD08D134" modified="2020-12-02" version="1">MGQKKKVGKQRRDKFYHLAKETGFRSRAAFKLIQLNRKFEFLQKSRVCVDLCAAPGGWMQVAKQNMPVSSVVVGVDLFPIKPIPGCISLVEDITTEKCKTALGKELQTWKADVVLHDGAPNVGKNWLHDAYQQACLTLSSLKLATQLLRRGGWFVTKVFRSKDYNALIWVLKQLFKKVHATKPQASRTESAEIFVVCQNYIAPDKIDPKFMDAKYVFSELELEPKNKLNFFHPEKQKKAKAEGYAENDYTLHHKLKVSDFIKHENGIDILQNASEIIFDDPAILNHAKTTNEIKECVKDIKVLGRKDLRNILAWWKILNEEYKKSNSTESKESVESDEEIGKEESKSDDEENLGDVDEQIANLQEEEIRDQKRKKKKVLKERKKLNERLNLKMILKNDDGPTMEGDDMFALKKVTSSVNKILDQTPDMVVNSDDEFSELKPMPKYKKYEKGEGHLDSTGTFYKDSDSELEMESDDEEDEIKEGLGFDEEDSDEQPSKKKTKRKANPKDKEDQSNPLITDLDYRDKDKKKAHKAELWFERDIFKNLIDEKDEDADLDKMVENFKKKGAKIYGEEDPKVDNIVKAGKKKSKKEITDSAYSSDGNDTDTDTDSDTDSDYDVEKEVGAPVNNSKKDGFEIVKSVSTGKKGKKYKLNSEELAMGTMMVNSKKAKRDLVDAAWNRYAFGDEGLPDWFKQDEEKHMKREVPVPKELVDEYNKKLEEINVRPIKKVIEAKARKKRRAMKKLERAKKKVESVLDNADISEREKARQVQQLYKKARQEPKKEVTYVVAKKHMTGKRVARPKGVKGHYKVVDPRMKKDIRAQKKKMKTMGRGKKGGKGGKSSKGPSKGNKGKQKAQDVHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4W3</accession>
    <name>A0A6P7G4W3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S15Aa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114337752</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144084.1">
        <property type="nucleotide sequence ID" value="XM_028288283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4W3"/>
    <dbReference type="FunCoup" id="A0A6P7G4W3">
        <property type="interactions" value="1309"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652291.1">
        <property type="protein sequence ID" value="XP_050508248.1"/>
        <property type="gene ID" value="LOC126885641"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G4W3"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144084.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14736" checksum="794D6B7DA5CD2EEA" modified="2020-12-02" version="1">MVRMNVLSDALKSINNAEKRGKRQVLIRPSSKVVVKFLTVMMKHGYIGEFEIVDDHRSGKIVVNLTGRLNKCGVISPRFDVPITHIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7Q4</accession>
    <name>A0A6P7G7Q4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Netrin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114334931</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140868.1">
        <property type="nucleotide sequence ID" value="XM_028285067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7Q4"/>
    <dbReference type="FunCoup" id="A0A6P7G7Q4">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285067.2">
        <property type="protein sequence ID" value="XP_028140868.1"/>
        <property type="gene ID" value="LOC114334931"/>
    </dbReference>
    <dbReference type="GeneID" id="114334931"/>
    <dbReference type="KEGG" id="dvv:114334931"/>
    <dbReference type="InParanoid" id="A0A6P7G7Q4"/>
    <dbReference type="OrthoDB" id="9972745at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000098">
        <property type="entry name" value="Netrin-A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028414923" evidence="6">
        <location>
            <begin position="23"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028140868.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46281" checksum="30A24B344E78D452" modified="2020-12-02" version="1">MGLTLRVMILFMMFLHASSVSSVNENFLKMFEGQQTPVDPCYDEDRPRRCIPDFVNAAFGVPVKASSTCGLHIPVHYCEAPEPGANPQCHLCDDRQAKTRFPATYLTDLNNPQNVTCWRSEPIPPVTSINAPPDNVTLTLSLGKKYELTYVSLQFCPNTPKPDSIAIYKSMDYGKTWQPFQFYSSQCRRVYGRPNRATITKTNEQEARCTDAHRYTGGDMGNFGQTSRIAFSTLEGRPSATDFDNSPVLQDWVTATDIKVVFNRLHMPIEDSSDTLDILVDERMLHKHLEEHQEIKEPSVQLVNEMQAVDNEEAINPKSAVTPDLGTNIIVTGYHQVTHQYAVSDFAVGGRCKCNGHASRCIAGRDGQLACECKHNTAGRDCERCKPFHFDRPWGRATTRDANECKGRNNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8Y8</accession>
    <name>A0A6P7G8Y8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor 15-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114337139</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028143337.1">
        <property type="nucleotide sequence ID" value="XM_028287536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8Y8"/>
    <dbReference type="FunCoup" id="A0A6P7G8Y8">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643534.1">
        <property type="protein sequence ID" value="XP_050499491.1"/>
        <property type="gene ID" value="LOC126880015"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G8Y8"/>
    <dbReference type="OrthoDB" id="6106870at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11465">
        <property type="entry name" value="bHLH_TS_scleraxis_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Scleraxis bHLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF42">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028143337.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20009" checksum="C67AD3E992D95773" modified="2020-12-02" version="1">MEFLHFSGQMSEQKFNGSANGDKKRKSYTFETEYGIPVRQRSQANARERDRTHSVNIAFSTLRTLIPTEPKDRKLSKIETLRLASSYISHLGTQLMAGPIDQPCLRFLKEDSSNTLNRHQVCTFCIAHKKSNRAVRTEEFECANFEGQYFLTPVTSPTGRTTVINAEELTTIYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBG2</accession>
    <name>A0A6P7GBG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114335640</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141704.1">
        <property type="nucleotide sequence ID" value="XM_028285903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141705.1">
        <property type="nucleotide sequence ID" value="XM_028285904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBG2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642524.1">
        <property type="protein sequence ID" value="XP_050498481.1"/>
        <property type="gene ID" value="LOC126879485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642525.1">
        <property type="protein sequence ID" value="XP_050498482.1"/>
        <property type="gene ID" value="LOC126879485"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002056">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001508">
        <property type="entry name" value="AP-2 complex subunit beta-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="8">
        <location>
            <begin position="684"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="9">
        <location>
            <begin position="802"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028141704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028141705.1"/>
        </source>
    </evidence>
    <sequence length="913" mass="100829" checksum="EA81060CA4B44646" modified="2020-12-02" version="1">MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDISSGLVEDQGFLEQLKELLSDSNPMVVANAVAALSEINESSPTGQPLVELSTNTINKLLTALNECTEWGQVFILDSLSNYTPRDEREAQSICERITPRLAHANAAVVLSAVKVLIKMMEILAGDTDFCNTLSKKLAPPLVTLLSSEPEVQYVALRNINLIVQKKPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQVNIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVATLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMVWIIGEYAERIDNADELLDSFLEGFGDENAQVQLQLLTAVVKLFLKRPQHTQGLVQHVLSLATQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLADKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRSAGIRKSLPARQGSAEDTSSAPEPTVIPNQESLIGDLLSMDLNAPAPAAAQAAVPASNVDLLGGGLDSLLDIGTTPAPPTSTGLLGDIFGIPTAPTMYTPPKTIWLPAEKGKGLEIHGAFSRRAGQMSMDLTFTNKAMQAMSAFAIQFNKNSFGIVPGSPLTVPALQPGQSLEYNLALATTGPVQRMDPLTTLQVAIKNNVDIFYYACQIPIQILFTEDGTLDKRVFLTTWRDIPAANEVQYTVNDVKGNTDGVSSKMTLNNIFTIAKRNVEGQDMLYQSLKLTNNIWVLLELKLQPGLTTATLSLKSRSVEVAPYVFQAYDSILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GG99</accession>
    <name>A0A6P7GG99_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Borealin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114337755</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144088.1">
        <property type="nucleotide sequence ID" value="XM_028288287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GG99"/>
    <dbReference type="FunCoup" id="A0A6P7GG99">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288287.2">
        <property type="protein sequence ID" value="XP_028144088.1"/>
        <property type="gene ID" value="LOC114337755"/>
    </dbReference>
    <dbReference type="GeneID" id="114337755"/>
    <dbReference type="KEGG" id="dvv:114337755"/>
    <dbReference type="InParanoid" id="A0A6P7GG99"/>
    <dbReference type="OrthoDB" id="6360905at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046466">
        <property type="entry name" value="Borealin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10512">
        <property type="entry name" value="Borealin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin C-terminal" evidence="11">
        <location>
            <begin position="176"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028144088.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33016" checksum="ABF0CB41CD3537A3" modified="2020-12-02" version="1">MFSLFCKVYLSFMPRTKAYNKKPTSKLDEEAFDRQFLLEILHKLKQEFIDLIDVKFRCMLEDDRREIMKQFSEEELNTKLCDLDNVLVSQSHASINLTRKQDLLNSTKSVRKGGKRLTRSSSATDEGYLTTESSNSVDRISKHQPRAKSKKIEKKTRTSTRLSRSLSRSHTDSTGQNFLTPANKKTPPNVYGVVTPKCKPNTPHVLLRRPKHNEVALSFQGSPLLTAAVAPDEFANINIPLNDGSLLSLRPQKGLRLSQIPKFDMDTMRQLQTLKDHISMVLGSSQNDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGA4</accession>
    <name>A0A6P7GGA4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="39" type="primary">LOC114337758</name>
    </gene>
    <organism evidence="39">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="39" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="39">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028144093.1">
        <property type="nucleotide sequence ID" value="XM_028288292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288292.1">
        <property type="protein sequence ID" value="XP_028144093.1"/>
        <property type="gene ID" value="LOC114337758"/>
    </dbReference>
    <dbReference type="GeneID" id="114337758"/>
    <dbReference type="KEGG" id="dvv:114337758"/>
    <dbReference type="InParanoid" id="A0A6P7GGA4"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="35" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="35">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028373045" description="Prostaglandin reductase 1" evidence="35">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="36">
        <location>
            <begin position="61"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="RefSeq" id="XP_028144093.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41922" checksum="D3E68AC0B0A00FE9" modified="2020-12-02" version="1">MWKWLVLVFFQLSVFDCAVKNNNNRSLHVPNFANRNLGDASSTCKAKYWTLVKYFDGFPKNTDMTIREENLPPLKNGEFLAKAVFLSVDPYQRVLGSFPDQVKLGEPFLGQQIAQIVETKNTRYPIGKYVRAPFGWRTLTISNGQIPDEDKPLDVLPDYGKLPVSLGLGVLGMTGMTAYFGLLEVCKPKAGETIVISGAAGAVGNLVGQIAKIKGLTVIGIAGSDEKGKWLKQELGFDQFINYKKDNIDEKLKQVAPKGVDCYFDNVGGEISSSVLYQMNDFGRVAVCGSISAYNTPVKPKVTIVQPAILFKQLKVEGFDNGRWTDRFPEAVKQYLQWIREGKIKYEETVTVGFENTFKAFLGMLKGENRGKAVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GI73</accession>
    <name>A0A6P7GI73_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Transcription factor HES-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC114342860</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028149464.1">
        <property type="nucleotide sequence ID" value="XM_028293663.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028149465.1">
        <property type="nucleotide sequence ID" value="XM_028293664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GI73"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293664.2">
        <property type="protein sequence ID" value="XP_028149465.1"/>
        <property type="gene ID" value="LOC114342860"/>
    </dbReference>
    <dbReference type="GeneID" id="114342860"/>
    <dbReference type="KEGG" id="dvv:114342860"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18913">
        <property type="entry name" value="bHLH-O_hairy_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028149464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028149465.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45839" checksum="5633F44F986C912E" modified="2020-12-02" version="1">MPTSEDETDYNRSREAQSTMSKAELRKTHKPIMEKRRRARINHCLNEIKTLILEAMNKDPARHTKLEKADILEMAVKHLQNVQRQQLAMAMASDPSVLRKFKTGFNECAAEIDKYMNQTDGVDNSMKLRVVNHLQKCIGGIEQVAQFSFGGFNNLNLVSAPTPPQISSTNSGDQNNNPRIQIPQGIQLIPSRLPSGELALLVPNSRNINFFPNGQRSSAFATVIPSSTEVPKPLSPPVSPMRQEDLRLRCRSPQGFRPVVPTTRTFNDEHQVPQISSTATQPLELKIVKYPISKKIDSPKKIAEPLCIITNQGERYRQAQMKEESANYEENIMQGVKRKYHEAHGLLTVASDNIFQPPAPKIIKTQLLTPDCQPSSSFSGDTDPRRVKQETTTSKDSSDSTDMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNY4</accession>
    <name>A0A6P7GNY4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114339064</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145495.1">
        <property type="nucleotide sequence ID" value="XM_028289694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289694.2">
        <property type="protein sequence ID" value="XP_028145495.1"/>
        <property type="gene ID" value="LOC114339064"/>
    </dbReference>
    <dbReference type="GeneID" id="114339064"/>
    <dbReference type="KEGG" id="dvv:114339064"/>
    <dbReference type="InParanoid" id="A0A6P7GNY4"/>
    <dbReference type="OrthoDB" id="10386523at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027803776" evidence="1">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028145495.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19925" checksum="662D3ACA29C398E0" modified="2020-12-02" version="1">MRNIHVLCIVGVIFNSISSNGILGQGISFGDLKDLFVAVDKIVENPDDFFDKVKQELQKENVTLRSLNFPEIPEFPQIPDIPKNFPEIPDIPENYPNTPQLRFLGIGSMFNKVKNTVTGIFGGATGALDLPVKAIVGAVLKVMRTIFGERISNVSSSIYCLISKCISLFINYVLPLLKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPI1</accession>
    <name>A0A6P7GPI1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 271-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114340557</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147113.1">
        <property type="nucleotide sequence ID" value="XM_028291312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPI1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653504.1">
        <property type="protein sequence ID" value="XP_050509461.1"/>
        <property type="gene ID" value="LOC126886550"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GPI1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001926">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028147113.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="61803" checksum="772D12E02534FDA9" modified="2020-12-02" version="1">MEVKEEFNEEKCKFEIGSNVNDVLLDSIKCEIKDESHGTFDSVDFKKISIKNEMEEDAEKQRNERGFSQEKNTLDVETTDVHSCNKEQSMSQSEEKTLTENMKIHSGGKTHNCEICFKQFRYASALKAHSRVHTGEKPHKCDICFKQFSRTTHLKQHLITHSGETPYKCEICFKPFAHSSTLKQHMRVHTGEKPHKCDICFKQFSRTTILKQHLITHTRESPYKCEICLKTFARADTLKHHLNIHSGEKPYKCEICLVQCSQRATLKNHMKIHTGDRPYCEICLKPFAHKISLAEHMYVHTGERPHKCEICFKRFSQAGSLKTHLRVHTGEKPYQCKICFKQFKSPLHDHIKLHAGHTPLQTGPHKCELCCKEFVRKSALNQHLKLHTGEKPYKCEICLNQFTQKNTLNQHMKVHTREQPYKCEVCFKLFSHPSALKQHLRLHTGEKPYKCEICCRQFSQSGSLKQHMKVHTGEKPYKCEFCCKLFAQSGTLKQHIRLHTGEKPYKCEICFNMFSCNDYLTKHLKKAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H0G6</accession>
    <name>A0A6P7H0G6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114344584</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151218.1">
        <property type="nucleotide sequence ID" value="XM_028295417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H0G6"/>
    <dbReference type="FunCoup" id="A0A6P7H0G6">
        <property type="interactions" value="1246"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641825.1">
        <property type="protein sequence ID" value="XP_050497782.1"/>
        <property type="gene ID" value="LOC126878950"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H0G6"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028151218.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15712" checksum="C09D46DA90FAA427" modified="2020-12-02" version="1">MIAKMTEGTATIRTRKFMTNRLLARKQMVVDVLHPGQPSVKKTEIREKLAKIYKVLPDVVFVFGFRTNFGGGKSTGFALIYDTLDFAKKFEPKHRLARHGLYEKKQQTRKQRKERKNRMKKVRGTKKSKVGASAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H0U6</accession>
    <name>A0A6P7H0U6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Homeotic protein spalt-major</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114349435</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155611.1">
        <property type="nucleotide sequence ID" value="XM_028299810.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299810.2">
        <property type="protein sequence ID" value="XP_028155611.1"/>
        <property type="gene ID" value="LOC114349435"/>
    </dbReference>
    <dbReference type="GeneID" id="114349435"/>
    <dbReference type="KEGG" id="dvv:114349435"/>
    <dbReference type="OrthoDB" id="8749569at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002027">
        <property type="entry name" value="Blast:Sal-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000708">
        <property type="entry name" value="Sal-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000215">
        <property type="entry name" value="Spalt-like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000291">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1106"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1301"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="1329"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="238"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="477"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="637"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="904"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="966"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1213"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1434"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="934"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1251"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1268"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028155611.1"/>
        </source>
    </evidence>
    <sequence length="1490" mass="163697" checksum="B986759DB0EC7F66" modified="2020-12-02" version="1">MSRRKQARPIRLLEDEDPTAAVCPSATNNNGALPSRLPSNSDGDPADTTEATISVSDTPCIDVPTIPEELPEVLMCQRCQEQFTEVQEYVTHKEECDKKAIKHDDPAHSDPEDMVVSEDDDDDEETGGKRLERMRRNRQDAANNNSVEENSPDEDSQRLEFPFPIPAAAPGHVTLEALQNTKVAVAQFAATAMANNADNEAALQELAVLQSTLFTLQHQQVLQLQLINQLQQQLQIDRRKEEEEAEATAASPAPSDTEVENTPVESPPPAPQALPVSREPTPASLPPPMPSNIQPSPAVEPPLPEVKTPISMPMQIQPPMCSISSSLASTIITHNDEQLLEEPNTLEMLQKRAQEVLDSASQGLLATNLADELAFRRSKGSMSPYDSKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPYKCNVCGSRFTTKGNLKVHFQRHSQKFPHIKMNPNPVPEHLDKYHPPLLAQLGQQSSLSPGGPPHPPHLGFPGGPHFPPTSLPLFRPQGPPPPEILGNRLPPSPHRLLDPPPRLFPPHPLFLKREEQETPADLSKPPRSPSPTEDKVQMPEPEENKDREPMEESKPLVSTPQITPKQENNFIENEHENEHERYSSSIAYDECSNSSKYSNEDLLEQRSPGGEPSENVQDEPENLSSRHNSIIGPLSISTGQRLPANFSFGHTSSPPSSTSSGSLGHFPSHILPDITKDPSLYTNLLPRPGSNDNSWESLIEVTKTSETSKLQQLVDNIEHKLSDPNQCVICHRVLSCKSALQMHYRTHTGERPFRCKICGRAFTTKGNLKTHMGVHRAKPPMRVLHQCPVCHKKFTNALVLQQHIRLHTGEPTDLTPEQIQAAEIKDFPSPGGFPSLPNSIHPFLSQGFAAPGLSPISGLPMNMRCDRDIKSEHGSMDDDDDDDDDDAMSSLDNQHMPPFSSSPSDIQNTGMPVNTIASQFSGSGLSCSAEDLCSNRTTTPPPIQNGDKSPSQSGVTSPGSAELRSSPNHTPVQIPRPPSSQQACSPAPSDNSVGALDLTPRSQPANTSPGPSTPSGTPSLFPSFGLLPSGGQSPLMTSALSSLTSSVLTSTSFSPLRLAVGPIGTLGRGNTTCNLCFKTFACNSALEIHFRSHTKERPFKCTVCERGFSTKDGCHCTQRRIQDEVENWRAQNQKSSLFNSISSVFCLPMTPGYASSRTKKAGNMKQHMLTHKIRDMPQHMFDKPPSMSGDDSTPLPPSLPKIENSASDNEQSQPLAPVPPPQVLQPPQLPPPPEKHELESQQIKREPTETELPLPKRPPSLQSSKHLCHVCNKNFSSSSALQIHMRTHTGDKPFRCTVCQKAFTTKGNLKVHMGTHMWSNGASRRGRRMSLDLPPIPMTPKDSEFLQRRPDLFYPYLPAPFLNGMQQKLNEISLVQNNHNGLTGAGKYSGLLGFGYPPPEAIRSQANSPERSERPPSHEPDTRGLWDLHFERKSAADAPREDLLPPTANREGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAP9</accession>
    <name>A0ABM5IAP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128698.2">
        <property type="nucleotide sequence ID" value="XM_028272897.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272897.2">
        <property type="protein sequence ID" value="XP_028128698.2"/>
        <property type="gene ID" value="LOC114324965"/>
    </dbReference>
    <dbReference type="GeneID" id="114324965"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="938"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128698.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1003" mass="113242" checksum="5E05A1549B4B1E42" modified="2025-10-08" version="1">MKRSPRVKTKVEPDMSSVMISDDEDLTMVMAHSPPKRITRERRTKYDKKFYALELTSDEDEISDKEDKDATFVLDDSVIEGKKETSTKSKPKRNLNNSSLVEITDDESDVETPVKKTKKRAPVKTKQPIVKAPIAKAPIKKPQVKKEPAVKKPRVKKEPTVRKTQVKKEPTSTIYNEFSSLDETVRATNENVIQDGDETLKTASARTNLKRKNSKVKAEAKSDLNPPKAKKLKTEINLPSTSLEAKHVNLNCETTWKDHELLAENMNLSKHIAYNVINLFNDGSTIPFIARYRRTQTGNMTPEDLRDVKSAYDDICTLKQKIKTVVNTLEKTGQKNRQIELIVKSSKSLEELEIIYAPYKPEAKRTLAERAKSLGLEQPATALFDNTCPVDLNQWVDASKEELKSLEDVQNGVIHIIAHKIATDSDMLSFLRDLRQNINFTLETKKLNAKQPKAKTKKSVIQEKPVDELKFQTYFDYSIPVKFIKPHQVLAINRGEHHKVLSVKISPPPYLIDTYKKFCLQKYINRGVFNEDRRTIVGDACIDAFSRLLLPSMVREVRSELKIMAEKASYEVFSKNLKQILLAAPIKGERILGIDPGYHHGCKLALISSTGKVLDQGVIFPHSVSDDNRDKSKTILKDLLDRHDCSLIGLGDGKASKQTEEWLSNLIRNKYFHPKDVKYTIVTEDGASVYSCSAEAKKEFPQMDTNIISAVSLARRIQDPLAELVKVEPKHLGVGMYQHDLKKKTLEEALDEVVSECVSFVGVDLNTASQCLLRRIAGITDKRATEIIKFRETNGAFICRDQLLKVPGIGPKAFEQCAGFLRIVPTNTASPSKFSKNYKITKLDQTIIHPESYDLTKKLLKSLKLNEDHIGEETLIQGVQAIKTELPEVCEKLDTNVETLNLIIDALEKPLNYDFRTEGSQNTFFAVELKDFDDVSVDDKMVGRVKNVTHFGCFVDIGISQDALIHSSKMNGLDLQIGDRVNCIVITVDKLRKRIGLKALSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IB58</accession>
    <name>A0ABM5IB58_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dorsal-ventral patterning protein Sog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chordin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129016.2">
        <property type="nucleotide sequence ID" value="XM_028273215.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273215.2">
        <property type="protein sequence ID" value="XP_028129016.2"/>
        <property type="gene ID" value="LOC114325218"/>
    </dbReference>
    <dbReference type="GeneID" id="114325218"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016353">
        <property type="entry name" value="Chordin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052278">
        <property type="entry name" value="Chordin-like_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46526:SF1">
        <property type="entry name" value="CHORDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002496">
        <property type="entry name" value="Chordin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50933">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046531120" description="Dorsal-ventral patterning protein Sog" evidence="9">
        <location>
            <begin position="23"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="11">
        <location>
            <begin position="279"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="681"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129016.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="104632" checksum="62FB8353CEE82181" modified="2025-10-08" version="1">MQVSRLLVFVTAFLAVLGLVQARMKSPLIDEDLPRSRNKAAECVFGKQIRELGSQWIPDLGVPIGVLYCMKCECVPFQRKRRIVARVQCRNIKNECPEPTCEDPVLLPERCCKICPGDNKNEPDVIQDIVPQNVIEEEERRINHFAALLTGRSSLDLRNDTMPKDLNKNNVVATGRFTFHRRNLHYSFYISEKAARPKFLHILDNQGNILEDFTLSHAGGLVNSPYQNATRKICGIWRRLPRDYRRLLKQEKLYVQLIWGTKDSEFTLSGKLTKYVALASELFSSLLEPAPGTDSAKMAGSGGTALVSTSSTPSPSVHVAVIFNGLFTSEESTGVPINVMLALDEKKQIIIEGNIKVNKPAPDLNLIELSSPVTLADLRSLSRGRVLLTVSSVSEPSALRLSGSIITKVTCEIFQALLVGDRDLASTSNGLAWMYLNNQGALIYTIQIDNRNTDQLHNVTLTDASGKRKAEVLTPYFHTGVAHGAEDRMVHKILEPLYNSRLDMRISVGNSSLHGHLNSKLVADARDGPAPILLKRENYSLPSTVGGIVWISVDSECHIHYDLSISGLGHERKLELYLEMYPIIAPGAPVLIKTLEEFEGNQVEGSPIEYLTKEELDMLDGGVTFVKLKDSLHKVVLLSATLTKIKLPISCRPPRDNNIIPVISGTYGNSRDQPGVGHPTESCFFEGKFYKKDSTWVSKNPCQMCFCQDGQPTCDVMNCPDIKCPHKNFTTPGECCSICGEPAILMSTKKCIFNGRTYSPGSKFHPFLIPIGFDDCTVCTCDPIDLEIKCKRIDSNTDKCGKGAATTPDTISDDNIGNWPIQRKEEVSNSELILKEGGCRNRMNPERPYRNQSTYHPYISSLGEYKCVTCKCQNGQSNCARERCEWKNCKMMFELRKSKSRNNKKSFPEEYCCTIKECRRIRHRKKLEERASHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDZ6</accession>
    <name>A0ABM5IDZ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130726.2">
        <property type="nucleotide sequence ID" value="XM_028274925.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274925.2">
        <property type="protein sequence ID" value="XP_028130726.2"/>
        <property type="gene ID" value="LOC114326530"/>
    </dbReference>
    <dbReference type="GeneID" id="114326530"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130726.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="314" mass="36598" checksum="B48B34D92443554B" modified="2025-10-08" version="1">MKPMFYLPNDWWLFLYYVFTVAGLTNVLVGIFKGRSYEGVSYQTFSVYVLWSVTTFTTYFYPDMRLPSEFHLLVLTGVMSMWITALYFPYRQTYQRKYDIKSYGACISLMIIMLYFLEKDFSKVLELSALSMSITLHIPQVVLVLESKKINLYILGFLIHLFFAKIFFLLHTICYPRYYVVDLIHGILGLLLVIVFIPLFWISDLKFDMSPFIEKDTKNIAQNTIKLEREGRLHPVDDIVTVVSHKQVIIKKKVQQKQQNLPKPDSGNGVQQKQQDLPKPDTEKGVQQKQPDLPKPHTEMVLKVVPIKPNDSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFG8</accession>
    <name>A0ABM5IFG8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131603.2">
        <property type="nucleotide sequence ID" value="XM_028275802.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275802.2">
        <property type="protein sequence ID" value="XP_028131603.2"/>
        <property type="gene ID" value="LOC114327259"/>
    </dbReference>
    <dbReference type="GeneID" id="114327259"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131603.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="405" mass="45194" checksum="15BF58A7B91543FB" modified="2025-10-08" version="1">MSVDESVKSNSNSQSESSGSSSTQLPFYEEHADNMTDLTLCGNLVPSLARSGTVKRAAGANFMQKKDKDIGCGSFSEGDDSVFSSKDKTSPDQSVNSRYRRSLDSTFRRSLESISEHKTKRCFSPTCTLSTASRCSSSLESFSSEHENPTKNSINNKNENEEEKLVQSPASSYLSWIESVNNEFIDTAATTEAKPTEVSEIDNKVGEWNNFWLNYNSARSRYMSSAYLSADEKAIDDVSDAKSSNSTHRELGEKPPGEYVLLTLEEAHEAIKYSKRLTEIFQTALVRNDHDCENSNLEASYYSESLSRQNSSIREDNASIFTNEDLKKVARERSASYIVTTQDLLKQQKDIIKPSIQSSSTSCINAILNTGVADILKRVMKRKDIMTPDDMSSMTRRSFSEWGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFT2</accession>
    <name>A0ABM5IFT2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elastin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131779.2">
        <property type="nucleotide sequence ID" value="XM_028275978.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275978.2">
        <property type="protein sequence ID" value="XP_028131779.2"/>
        <property type="gene ID" value="LOC114327382"/>
    </dbReference>
    <dbReference type="GeneID" id="114327382"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047436701" description="Elastin-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131779.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="16923" checksum="8DF61BCB08916FA4" modified="2025-10-08" version="1">MNSMIALTFVALVASASASGLGLGLGLGLGGWGNPGLLAARALSPIGPSGVVTGAGAAGPSGVVTGAGAAGPAGIVTGRGAVGPTGPNVGGILAGPGALGLGLGVPGIGLGAVGPAGVVPGALGLGWGLGGHGPSGVVTGAGAAGPSGVVTGAGTAGPVGIVTGRGAIGPNGPNGVGVWGAPALGGWGAGRWGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHN5</accession>
    <name>A0ABM5IHN5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133010.2">
        <property type="nucleotide sequence ID" value="XM_028277209.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277209.2">
        <property type="protein sequence ID" value="XP_028133010.2"/>
        <property type="gene ID" value="LOC114328373"/>
    </dbReference>
    <dbReference type="GeneID" id="114328373"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133010.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="445" mass="51499" checksum="643DBA58E16B3F9B" modified="2025-10-08" version="1">MRRPGYRRRLRGLQTLQSLKTMILTKIRITEMRTLGSITGYSLREKRNGFVSEQGCVRDMNSPPTVQELIDNISKLKPNLESQHLKHEDDIFSHNCCLSNKKRHEIVILSPVIDQISKGVEADLVLDIGSGLGYLSHHLHSKYKHKVLGIECSKQYVVQAYKMQQKIYPHCKNGVQFVDHYIDAQSAGKISSLIQETFTDFDPKSVSLVGLHACADLSVTVLDLFSQLDRVKSLVIMPCCYHRLKLKEEQDDKEYFYNFPFSNVFKDIFDKASGEYFLRRSFLRLACQQASRNFCNMSQEEHVEHSTNLMFRCILQLVAESENLDIKRLKRKSTTHSSTTDIEDYLSHLPSTHQLKPRNPNDNHLSITDEVFLNKMRDKWNEYKDKCFLLEVLTGLQAALQNVCENIVLLDRVEYLKEKGFEARVQKITDDLVSPRCYALIARKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRM3</accession>
    <name>A0ABM5IRM3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgi apparatus protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139785.2">
        <property type="nucleotide sequence ID" value="XM_028283984.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283984.2">
        <property type="protein sequence ID" value="XP_028139785.2"/>
        <property type="gene ID" value="LOC114333981"/>
    </dbReference>
    <dbReference type="GeneID" id="114333981"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997:SF2">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139785.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23710" checksum="8BE0850BB0CE9E9A" modified="2025-10-08" version="1">MTQLPYFILLGLSHSIYYCEIANYNDDVCTPEKVQAKQLLLNECLNRREGAYAFSQTLMRPSGSIAEFLKKRCAMKPHLDDCLDLWLDLIKECVNADDLRGLEVWKKIDAEIINYVCAHDAEAMTSLLKNRYHSCRQGLSRILTDCSRSLGITVPYYQVDKVRQKCNKIGTMESCVTSKLERNCMRNATELAKPLFHIVKTNLCSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWR2</accession>
    <name>A0ABM5IWR2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145713.2">
        <property type="nucleotide sequence ID" value="XM_028289912.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289912.2">
        <property type="protein sequence ID" value="XP_028145713.2"/>
        <property type="gene ID" value="LOC114339286"/>
    </dbReference>
    <dbReference type="GeneID" id="114339286"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040479">
        <property type="entry name" value="CLIP_SPH_mas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF140">
        <property type="entry name" value="BCDNA.GH08420-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18398">
        <property type="entry name" value="CLIP_SPH_mas"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046844656" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="471"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145713.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="715" mass="76841" checksum="AAFC058244FB75F3" modified="2025-10-08" version="1">MLYRTRGFFILVFFLGVQAQDDSLAGSFLSGLLDTITSTADSKDCPGVCVHALATIICYGVLHDVSCPSPSMKCCIDSPMPNATTIESVTKSETTSLMTTITTSTPTTLLPATTSTMISVEKKHNITDLNEPGSCNSTEFKGVCVAENIANYCEAILNTNDLCTPGLRCCVSSVTFGDKLPSNLIYPNKTKTNYTRIETRTTHRPHSSTTYPVKKTTVSQPVTLKECNGECVSGLFALFCDDIDSDADCENGASCCITEPVSNNESEPEKSVSPPTMRPPLPPTTTRPVIRDPGPICPGFCLLNIMAAFCERPSVLIPHTSNCKRGSVCCDNTRAMTSATKPKPKPHYSVPTTTTTVDSRPECPGSCIVSYLSFTCFRNAEMTEIFKCKKAGTKCCAPKSLIKDALGQKDDVPFEESTIQSLSMSYTTISSANPTHFATTEMTRMQSTTSKSPVYSKYVCGVKGTARVGRVVGGEDGEQGEWCWQVALINSLNQYLCGAALIGTQWVLTAAHCVTNIVRSGDAIYVRVGDHDLTRKYGNSEAQTLRVATTYIHHNHNSQTLDNDIALLKLHGQAELKEGVCLVCLPARGVSHAAGKRCTVTGYGYMGEAGPIPLKVREAEIPIVSDAECIRKINAVTEKIFILPASSFCAGGEEGNDACQGDGGGPLVCQDDGFYELAGLVSWGFGCGRLDVPGVYVKVSSFIGWVNQIISVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH82</accession>
    <name>A0ABM5JH82_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497297.1">
        <property type="nucleotide sequence ID" value="XM_050641340.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514181.1">
        <property type="nucleotide sequence ID" value="XM_050658224.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641340.1">
        <property type="protein sequence ID" value="XP_050497297.1"/>
        <property type="gene ID" value="LOC114344185"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658224.1">
        <property type="protein sequence ID" value="XP_050514181.1"/>
        <property type="gene ID" value="LOC126889698"/>
    </dbReference>
    <dbReference type="GeneID" id="114344185"/>
    <dbReference type="GeneID" id="126889698"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="128" mass="14209" checksum="750C7E2FC87B7AE7" modified="2025-10-08" version="1">MLCPPTKTMKPGKNSAEFPRTPKQLNTAYINVKRVTSQKVAEENIQKYNEQKVLDQLKRDQTADKKDMLATGGGTFRPRLTDVGAQMLSLIGNQIQPLPNSCDSASGFFTSVAQDSQVEVDYLQLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHF2</accession>
    <name>A0ABM5JHF2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497367.1">
        <property type="nucleotide sequence ID" value="XM_050641410.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641410.1">
        <property type="protein sequence ID" value="XP_050497367.1"/>
        <property type="gene ID" value="LOC126878598"/>
    </dbReference>
    <dbReference type="GeneID" id="126878598"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="41232" checksum="B189EB5541F4FF77" modified="2025-10-08" version="1">MSQGRKGLRNKKNEEDVEVDGETQQAEQEQSVAQVLQETTGITQEREENVNMTALMSLMMQINKKLEEKVYINSLKHKLRSVNNINDIKDYIRMTLSDNAATWFASIENDLDNLQTFENKFLNYYWGELEQARFREVLYFGKYNRNLSLNMVDYALKLITVAKYLEPPLREDETVLNVSRHFNVDVVQTVTVQNIQTVDSFINFIQRVQRGYITSNNSKNRQSYNNNRYGSNSQNFNNNNNTSYERQGNRENFNNNTNDNRQERQGNRENFNNNNNYNRQDFNTRRNAQRYNYNRQVNYVRGQSCEDSQRNSAWQENMNSRSESSERHRELDPNDQTQSDNPNNPNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIH7</accession>
    <name>A0ABM5JIH7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497742.1">
        <property type="nucleotide sequence ID" value="XM_050641785.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641785.1">
        <property type="protein sequence ID" value="XP_050497742.1"/>
        <property type="gene ID" value="LOC114337914"/>
    </dbReference>
    <dbReference type="GeneID" id="114337914"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF17">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="659"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="764" mass="83328" checksum="3BF6F0B13F601EC6" modified="2025-10-08" version="1">MKLGMWEVDRDALRKDGLVLFSKLIRTKNVDNLQERQPRSDDTKQKLAKCLTTLDLTSLGVGSCVGTGMYLVAGMVAKNVAGPGVVFSFIIAAVASIFSGACYAEFGVRVPHTSGSAYMYSYVTVGEFIAFVIGWNMILEYLIGTSACACALSACFDALANGAITHAIHESIGKNLGRDPDFLAFVITLLMMLLLAAGVKKSLIFNNILNVINLAVWVFVMTAGLFYVNTDNWTKHKGFLPKGWSGVFTGAATCFYAFIGFDIIATTGEEAATPKKSIPLAIVSSLAIILIAYVTSSMMITLIVPYTEVDEDSALVEMFGQVGAYKCKYIVAVGALAGLTVSMFGSMFPMPRIIYAMAQDGLIFRIFSQVWPSTGTPALATFVSGLTAAIAALFIRLEILVEMMSIGTLLAYTLVSTCVLILRYQPHSTNLVELLPQSLRTPIRGSPTKEALADNPGGQVLYGNQLHPAQLKQAIDASLGPPIPSPSPSPLPSQTTQRVMVRRVTRSSPDSDDTFGGDEPEEDFSGRDDQFLVSDRTENKFYGTVHGGGSATSTGGVVGATVGPSLGYIGRRLQAATYLCPAIFPWVDTGPATEESGMFVMKMVGNLYILIIIFDLIVVCGMDNMNTATSIFLWLFFLAIVAICLMISRKPQNRNTLMFMTPGLPFIPVVAITVNIYLIMKLSILTLVRFTTWMTLGFIMYFYYGIKNSTLEEGPDTDQNIELTVTDHEKPKYNSNTPYGGDHNIFRLKDDPHWLSMFQFYIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIR8</accession>
    <name>A0ABM5JIR8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497836.1">
        <property type="nucleotide sequence ID" value="XM_050641879.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641879.1">
        <property type="protein sequence ID" value="XP_050497836.1"/>
        <property type="gene ID" value="LOC126879002"/>
    </dbReference>
    <dbReference type="GeneID" id="126879002"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046653923" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14529" checksum="4F825D17D34F739B" modified="2025-10-08" version="1">MQLANILIIALVCLTAYTANTERGRLSELVKECQKESGSTVNEIEIIRNNGVITPDTGKQALCVNRKFGVLDQNGDVIPDQFNQHIEVLSGGNSDARKEFKDNCSKTEGENPEAKAIKFVKCMQTVLAKYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIV5</accession>
    <name>A0ABM5JIV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497870.1">
        <property type="nucleotide sequence ID" value="XM_050641913.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641913.1">
        <property type="protein sequence ID" value="XP_050497870.1"/>
        <property type="gene ID" value="LOC126879031"/>
    </dbReference>
    <dbReference type="GeneID" id="126879031"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047120400" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="248" mass="27313" checksum="7F8DF1CF1A3348C6" modified="2025-10-08" version="1">MFIHNGFIVILIFLFLFENVPIYAGNHFRIFGGSETSIEKHPWMVSLQHSSLGHFCGGSLINYDTILTAAHCIIGDSASFHLVAGTSRLVDKGFTLKIKNITVHEKWTMSPNLKNKYDIAIIKLAEKVKFSKRVKTILLPDQDIKVPVGTALVVAGWGDIGSHGPQSDVLKEATVSVMESDSERLIYAWDKKSGVCSTDSGGPLELNGTLVGIVSFGPAKCEENSQPAGYTNVAFFRGWIKETLEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLE7</accession>
    <name>A0ABM5JLE7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_050498759.1">
        <property type="nucleotide sequence ID" value="XM_050642802.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642802.1">
        <property type="protein sequence ID" value="XP_050498759.1"/>
        <property type="gene ID" value="LOC114330073"/>
    </dbReference>
    <dbReference type="GeneID" id="114330073"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="11">
        <location>
            <begin position="68"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="463"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="593" mass="67718" checksum="743EE5454D62BC15" modified="2025-10-08" version="1">MELENIVANTVYLKAREGGSDSNKGKSKKWRKILQFPHISQCIDLINKIGIDSYSSGIDVRYEYVVDQQPIGKLLFDQFCEQKGPAYHRCLRFLDAAKRYEVETDEQRLELAKVIKKEFMVEQEGQESISLPELGVIFPTSDKLTNGHKDLFAPCVQAIKETLAGEPFREFTASMYFHRYLQWKWLESQSVTYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMVLIEKQILQKINSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGDPGLDITRARFYAAEVVCGLDHLHQQGIVYRDCKPENILLDDAGHVRISDLGLAVDIPEGESVRGRVGTVGYMAPEVIDNERYTFSPDWFSFGCLLYEMIEGQAPFRARKEKVKREEVDRRVKCDQEKYSNKFSEDAKSLCQQLLAKSPQQRLGGKAGRSGASVVKQHQFFHPHINWRRLEAGMIDPPFVPDPHAVYAKDVLDIEQFSTVKGVNIDESDASFYNKFSTGCVSIPWQTEMIETDCFRQLNVFGPNSTRTPDLVLQPTTVSENEGCFPFRRKKKQLPRTRPIPINPTLLPQVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JP84</accession>
    <name>A0ABM5JP84_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 191</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499752.1">
        <property type="nucleotide sequence ID" value="XM_050643795.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643795.1">
        <property type="protein sequence ID" value="XP_050499752.1"/>
        <property type="gene ID" value="LOC114329488"/>
    </dbReference>
    <dbReference type="GeneID" id="114329488"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="63363" checksum="F27830B6C8504CC4" modified="2025-10-08" version="1">MISVCEKTKSLMPPESMEIIRKHTFSSPKEYSNLLDWSNESFWEDLPNPKHNSSTNKPIKSTNNIPSKTISIETVFGDLLKTNPNQNNQKIIAQEQFFNKKTQFLSEKYFNIWKTAVELKKDQKRQEEAKLNQTTKLDTFMKKLKKRRKSEKEGINIKEEKAKIRVVVKDVSSSVVKPCSSFKNRFDVQKSIIELQKSKLEEQNRIIQDLKLGIINDDLLKSIENTKINIREIFGSCSGKNKYKIPLILGEEPKFSITSQVAPKIVQKMEQRALERAKNREIILERKKLIEEKRERMLQEAIERKRVLEEEEKKRSLEIIKERRRKEMEMEKIRCMNKQKYMAKLNTAVEFYNRLLLKQTLLQLYSYMKDGRDKRFLAVDYYEKKILKESIVSWQQVVESAYKVKYEIADAHFEYKLLKRSIQCWQKIHVESIRNMQVAEDLYDFRLTSNVFIHWNRYVCIEFMIQHKMMKKAESHYKRWLLFHYFHLWRSLKAVNELLKAKELKKARWRQKVWEILPDYKPLDPIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR38</accession>
    <name>A0ABM5JR38_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500400.1">
        <property type="nucleotide sequence ID" value="XM_050644443.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644443.1">
        <property type="protein sequence ID" value="XP_050500400.1"/>
        <property type="gene ID" value="LOC126880528"/>
    </dbReference>
    <dbReference type="GeneID" id="126880528"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="642" mass="72856" checksum="454E85CF09952B0C" modified="2025-10-08" version="1">MEETYKRSEIWLHFSPSSDGKAKCNICGIIYSYKGGSTSNLKKHISIKHHTFLNKHASSNTGASSLKRLKPNDDEDAQSIASTSSQITTLTSVSESALPLSSKKLKQPSQTSILSHLNRPCSLRRQQELNDLILHMIVHDLQPISFVENGGFRDLMAGVEPSYVIPSRFTFTYSFLPQKFSQKTEKLKGLLSTASSVSITTDGWTAQHSQTSYLAYTVHFITKDWTLYSTLLKCHQFDDSKTAQHLKDDLYSVVNEWDILEKVFSVTSDNASNIKAAIKLTEWGHIGCFAHTINLIVQSGLEISDVSPLRKKVKAIVEYFHRSTKANTKFKAMQGQMNEGQRSLKLKNDVATRWNSTYFMIERFLKVREPLTATIGILQIPVELLTESEWVALKEMCCVLKPFEQLTTEMSAEQNVTLSKVIVIVKGLLSAVHKIEQSTTSDKIKNLIYHYEKEIGTRFGSAESNTLMARCGFLDPRFKTKVFDSDYNSNSTKEHIQHEVAKLIISERRSEDIIHDHDNDEVNTGEETAAYDDQNLVWEDFDKAVETPKDIDSKAAAIIEVRAYLAESLIPRKENPLEWWKTRAFLYPHLAQLAKKYLCIMSTSVPSERVFSTAGQLISDRRNRLTGENVEMIMFLHENENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSI0</accession>
    <name>A0ABM5JSI0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500894.1">
        <property type="nucleotide sequence ID" value="XM_050644937.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644937.1">
        <property type="protein sequence ID" value="XP_050500894.1"/>
        <property type="gene ID" value="LOC126880866"/>
    </dbReference>
    <dbReference type="GeneID" id="126880866"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="243" mass="27145" checksum="D2D2789879511EB1" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVEIQFTLANIKSDATKFNYIVANLDTAYILEVRDIIVSPPVTERYAKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPDNIVRSLWLGRLPASTQAILATKAKASLDAVAELADTISEAIAPRAQISEGSNTLESTIDKLTAELADMKIQLASLTQAQAQTNTYRRNRSNSRQRPYPRDHLEKHQGNIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTB6</accession>
    <name>A0ABM5JTB6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Balbiani ring protein 3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501182.1">
        <property type="nucleotide sequence ID" value="XM_050645225.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645225.1">
        <property type="protein sequence ID" value="XP_050501182.1"/>
        <property type="gene ID" value="LOC126881153"/>
    </dbReference>
    <dbReference type="GeneID" id="126881153"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1510" mass="169559" checksum="09DEF1F8C666C704" modified="2025-10-08" version="1">MHDCLCPSTPTAERRKPITTSSKNTSCFTTSDNNCNNNCSRCDILYSCTNFPDKSISHYTTATGEDCSCLNCVCSEMEIQNQTCDCVTCVCSVCFENGKKAPYTTYIPSTTCDCQNCVCSVCPSPAGQPKDRGDKGITAPRSGLQPIEQSKGQTYSFCKCLTCDVDGREPNFHNPQLECNCNICKCSPCTHQVHTEHTQKVHTEHFVGQPMGHTSSFCKCLTCDVDGREPNFHNPQLECNCNICKCSPCTHKVHTEHTQKVHTEHFVGESTGRTSSFCKCLTCDVDGTELQSFHNPQLECNCNICKCSPCTNPNKALKTIASSNTRDLLTDQCKCFTCQDATMHKPDFFKTKVSCNCAKCECDPCADEDKRRQLETKQGGTIAVLGSNLPSTGVDYCPCTNTCTCLTCQDASMHKPDFFKTRVSCNCLECRCDPCIAENKQRHIPRHIEEGENQLVCSNDDCHCDPCPDSTKAVYKNQVEIVEQTKGEPCDCYICKCSMCKDPNVTQAKGDITRETQISKCHCTKCTCEPGDPAIHPITLKEDKTRNCNCVTCTCSPCDFPNSAQQALNCQCIVCQCSLCQLTNDQLPVSPLMPCNCTVCKCNPCGDPNKYRDQIDHEPHLAGCDCLTCTCNPCADPAVQRSKQPDQLIQEAGHPQQFGAHEMKNCNCVQCCCKGSTAEQREKKVDATDEEVPCSCPICMCKKDKNTHGKGDEIYADEKMVESKYKSTPSSKCTCETCRCGDGTKQLAKTDVPIQITRSIHDRDCICKECLCEELQKTSTIEFVKCHCSTCNCVDCLFRQPEPQRKIQDRTITKIPTHCTCRDKMANECICKECKSFSDVSTELDDKATNSLCSCSACSCLTCHTKKVENIENMKCYCEKCKCENCKFIKYQTREFNIKEELGDNKNLCTCSPCSCTDCVLNNKIEGKAIKNNNPCPILEAKCTCVEIPMSQPTRIEQQSEYVPNVPKMKQHHSYAAYHAFVDPIHVHKKLQNLTSLPETEKIKAAKGQKIEAENLYNYLPILLPQSAMPVRTQAKRKKNYKSSKSKKARGLTRSAELSRFKQFGLSRSKPIPYSEEVFPVSQSDVTNNRTIFHQLDPNLPEKPYDLTGNNKSFLKDKCKYEEQIKILKKTLNKIKGLKEKYAHNSHKRSVFKKSCEYEESISEISTAFKNLKKHCKADDKTIKELTEELKRYTSSTTFFNISTSVQQESEYDHTVTELSVDIQQQFPCYNPLRTSVPNIPVVQQETVKIRPATATLGQRRRGNICDCALCTNAHPDIYSNTGYKISSRHSKLIRTINYDTFNKPNTLSHNLALTCKEDKRESEFPPYYILQPYCLTKENIPVECENHHETEMINAPDFVQPAAGLNETVNTWRNKCATDNANDIKMTKNVETQSFDRPKFNGVACKCGKYHKDNRFVNLTGFKVINVKRITVDSIVVEWKCPKSKAVTGYDIEINGKQKSKILSGWRTCAMIHSVDLSSVLYISIYAITPCGRCEPPAKAIYEIKQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU77</accession>
    <name>A0ABM5JU77_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501490.1">
        <property type="nucleotide sequence ID" value="XM_050645533.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645533.1">
        <property type="protein sequence ID" value="XP_050501490.1"/>
        <property type="gene ID" value="LOC114340546"/>
    </dbReference>
    <dbReference type="GeneID" id="114340546"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="252"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="81296" checksum="EEDF3450D0447762" modified="2025-10-08" version="1">MLKYYFIALYVSLYFSVGCCAALTYRLNPSKAVPRTYEIVIKPDLDNDVFHGQVIIYVVTKESLNGITLHSDELNITDVYINQIKGRYVEETEGRITVKYNNGSIQPGEHTLLFKYSGNFQIDSSRQSRGLVKALYDYNGTEKYVYVTDLEPNWARKVFPCFDEPQFKAKYHIKLVSPNETYVAISNMPEITKFRTSYGIVHEFAASVPMSTYLVSFAFTNFPYYSETFEDKGRQIPIRIFTVNASKENNEFAMQCAKTAFLFYSNYTDISYPLPKLDMIEYQRVGTSATENWGLITFRQGLLTAPLEIYNEFQIKLVMFHELSHFWFGNLVTNAWWNDIWLQEGFASYMSYKLSAHVNNETQLGEMKAFQFTDFFEKEIYKKSQPIVQYLPDSSKIDDVFLGLVYEKASAILLMLEDQVGQEKFREIIKKFLNKYAYHTATTNDFITVVEEVVPDIPLRTFLESYLYQHKFPVLNVDIVDSTTYVITQQVCETFHQENISATKWTIPISYRADYSNDSKHIWFHREMDELRLEESNAKWIIFNPEGNQMYKTIWSTNLWNKIISNIEFMDYSTTDTVISDALYSFQFNKIKCETVIHLMKRFGTGHKERWELFFPLYDHLKENLFCHKYTEESKLLWKFQNKRYAETNHKQMPKFREPESCDDKSIIQNEVYRNNLGECATWIRKNLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUA2</accession>
    <name>A0ABM5JUA2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501518.1">
        <property type="nucleotide sequence ID" value="XM_050645561.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645561.1">
        <property type="protein sequence ID" value="XP_050501518.1"/>
        <property type="gene ID" value="LOC126881337"/>
    </dbReference>
    <dbReference type="GeneID" id="126881337"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13300" checksum="F4E8C28B38516A2B" modified="2025-10-08" version="1">MWQTSLTRRDKPQIDLQLQSTPNNTINNQTTLGPRDLIYTARTATEHPAATEPPSQPEQTQLGQPQSFQPRQSHQANQNKLSQDSHRASSHDRATEPTRTNTARTATEHPATTEPPSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYJ3</accession>
    <name>A0ABM5JYJ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503009.1">
        <property type="nucleotide sequence ID" value="XM_050647052.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647052.1">
        <property type="protein sequence ID" value="XP_050503009.1"/>
        <property type="gene ID" value="LOC126882231"/>
    </dbReference>
    <dbReference type="GeneID" id="126882231"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="273" mass="30440" checksum="0AAD1E0F536159EE" modified="2025-10-08" version="1">MADTNLLENSSDLSKLKVPDLKKELKQRGLSTTGNKNELIERLQNAVKSNETINSECVDDLEEDLLNDEDDDHEDASESVILDNELDEGLPSLPVKRKADETSATETIPEPPKKVVLKRISSSELDTEEEKSEPEKVDAEVKPEEDKHEDKKVIKLSELTTKERLEMRAKKFGVIVNSPDAKKAARAERFGTSNASADSITSSQVNTKLDVLKQRAARFGVSVSSAMSNLENKEKLEKRKQRFGSDTEGKSSNGVSESDKAKLRLERFKEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0Z5</accession>
    <name>A0ABM5K0Z5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503851.1">
        <property type="nucleotide sequence ID" value="XM_050647894.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647894.1">
        <property type="protein sequence ID" value="XP_050503851.1"/>
        <property type="gene ID" value="LOC126882810"/>
    </dbReference>
    <dbReference type="GeneID" id="126882810"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="500" mass="55331" checksum="B1AB87DE74E8BD39" modified="2025-10-08" version="1">MADSEICKSANYEECVLKDVNTMTCSDNNDVKSARKSDTFFLYFTIFTGSLPWFVGGMSIVWASPALTKLQLNDTEVNPIGRPIKPSEVSALLVSQAVGGIIGTLLLPKLADIFGRKRSIQILSFVMILSTSGVAFSTYIELIVFCAAITVVAFCGIWGICPIYITEICEDHNRAKFSCFMAASIPMGELFCYIIGSLLSYKLYTMVMTLPLLLHLALSLFLPESPIFSLTKNKKTDCLIALRKLRSNKSNEEINTDFENMCNNLTKINSTKGLGVRQLLSIREGRIGLLLSLLPICVQNLCGVPLLMPLMAPIFNKSGSNLSGNIIAMYVGLVKIITFITASMVVEKLGRKPLLITSSIGTGICMIVLGIFFYLKHINSSFILQFQWVPLTCILIYFIFYGFGLGPVPYSMISELFPSNLRSAASIIVLTAVGILIAVYLAVFLTLAEAIGIHWCMEMFATMSFIETVLFYMILPETKGKSTEEIQDIVKNLKIFKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1P1</accession>
    <name>A0ABM5K1P1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Gamma-aminobutyric acid receptor alpha-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504106.1">
        <property type="nucleotide sequence ID" value="XM_050648149.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648149.1">
        <property type="protein sequence ID" value="XP_050504106.1"/>
        <property type="gene ID" value="LOC114329928"/>
    </dbReference>
    <dbReference type="GeneID" id="114329928"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19007">
        <property type="entry name" value="LGIC_ECD_GABAR_GRD-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
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    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
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    </dbReference>
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        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044949276" description="Gamma-aminobutyric acid receptor alpha-like" evidence="18">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="41"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="256"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="54496" checksum="7D92D1FE9AFBF362" modified="2025-10-08" version="1">MFCFILILSIITSTVDLSSIVIMSGTGTLSQQNNHKNISLLLDNLLRGYDNSIRPDFGGPPTIIEVDIMVRSMGPISEIDMTYSMDCYFRQSWRDKRLSFFSHTNYTLALSISMLAKIWKPDTFFYNGKQSYLHTITTPNKFVRLHHDGRVLYSSRLTIKAGCPMNLENFPMDIQKCPLTFGSFGYTKKDVLYRWNFARQVAIADDMKLSQFDLIGTPSGNNSFNPFNGDIRSEYSVLLVSFHLQRHMGNFLIQVYGPCVLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEARTNLPKVPYPTALDFFVFLSFAFIFATIIQFAVVHYFTKYGSGECYFSFSSDSSSEDEDSNTSYVQPKASKSVAKSVHECSKPNPRFDEIIQLTDDLLPSTSTKPATKPPARRLSHQAPPTAKRRFSVASRRVSTQSSKGYRKKKRSPRFNSVSKIDRVSRILFPFLFIAINTFYWYSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2B6</accession>
    <name>A0ABM5K2B6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504333.1">
        <property type="nucleotide sequence ID" value="XM_050648376.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648376.1">
        <property type="protein sequence ID" value="XP_050504333.1"/>
        <property type="gene ID" value="LOC126883129"/>
    </dbReference>
    <dbReference type="GeneID" id="126883129"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="THAP1/10"/>
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        <property type="entry name" value="THAP_Znf"/>
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    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
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    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_THAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
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            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="205" mass="23645" checksum="86A5ECD9A1644DC9" modified="2025-10-08" version="1">MASVTHKCVYAGCFERNDGTNNNISFFKFPLKDVERTKIWQKNCGNIDILLMDITDLKQRVICQHHFAVEYIYQSGQRKLLRKNAVPLKFTQLTTDLGDIPPVCSTYVYCGTKRKRSTSDDCMVRSTPSPKRSSSSLSDISSFEINLPTKLETELTEKVKKLEYQVSALKKKCRQKNSRRCRRTTKNKKSATKFMLQVLLENKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4Q2</accession>
    <name>A0ABM5K4Q2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505168.1">
        <property type="nucleotide sequence ID" value="XM_050649211.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649211.1">
        <property type="protein sequence ID" value="XP_050505168.1"/>
        <property type="gene ID" value="LOC126883568"/>
    </dbReference>
    <dbReference type="GeneID" id="126883568"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23723" checksum="E3BF455658812A81" modified="2025-10-08" version="1">MPHIQVSDSEKLRLYKFIENGSNLELAYRSWEYHEIPLLPQTMKFNWNLKTTSLLERPRFVLFALQTAKKNAIKEDASHFDHCNITNLKLFLNSEMYPYDNLNLNFDKKQYAIAYEMYAQFQQSYYYKVGDPCLSLEQFGSFAPIFVIDCSRQNESVKSGSVDMRIEIETNKNIPVNTAAYCIIIHDRIVNYNPLTNVVQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5B7</accession>
    <name>A0ABM5K5B7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050505391.1">
        <property type="nucleotide sequence ID" value="XM_050649434.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649434.1">
        <property type="protein sequence ID" value="XP_050505391.1"/>
        <property type="gene ID" value="LOC126883769"/>
    </dbReference>
    <dbReference type="GeneID" id="126883769"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="115" mass="13682" checksum="798109CC6CE15A5A" modified="2025-10-08" version="1">MNPLELYQLFELAGTVAEQGINFVYLYGFSLQLFIDCFFGTYLYHQASLLPDAIFHSNWRMLEDKELKKDFAFLLQNSQRIPQFNAYNLYDMHMYSYVKVIKVAFSFYTILSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5B8</accession>
    <name>A0ABM5K5B8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505378.1">
        <property type="nucleotide sequence ID" value="XM_050649421.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649421.1">
        <property type="protein sequence ID" value="XP_050505378.1"/>
        <property type="gene ID" value="LOC126883756"/>
    </dbReference>
    <dbReference type="GeneID" id="126883756"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="425" mass="48469" checksum="525004D1C79ABDC8" modified="2025-10-08" version="1">MEHLKTLRVKRGSLEARLSNFQVYVEKCMTQIDSIDDRVLKNRLSDIESLLAEFSELQVGIECSVKKEDLQGEYDKRKAFENDFYSIISKAQGLVKENSTDNVGSASVSNPENSRFPSSSEVRLPALNLLIYSGEAGEGLQFRDSFDSLINSNLSISNVQKFHYLKRALKGEAFEVIANIQVTHDNFPIAWDLLCDQYTDNRALLHVHTKALFDIHPVKKESLKSLSHLVDHVRMHLRSLKSLGQPTESWDTLIIYLVFTKLDPVTIREWESKDFMNDTPKLEAFLTFLKQKAKMLKRMEEKHTEANSSQNVKGKTSKPPAESSNRSNSHVQRSYHISDRTCASCDAPNHKIYTCTKFLRLSVPERTDLVKKSNLCINCLNRGHQVNNCNFGHCKNCTVKHHSLLHVSEPSTSNTNAQQFLFTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5D0</accession>
    <name>A0ABM5K5D0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neuropilin and tolloid-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505395.1">
        <property type="nucleotide sequence ID" value="XM_050649438.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649438.1">
        <property type="protein sequence ID" value="XP_050505395.1"/>
        <property type="gene ID" value="LOC114333420"/>
    </dbReference>
    <dbReference type="GeneID" id="114333420"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21426" checksum="605D05042351C73A" modified="2025-10-08" version="1">MASNDKEFCGSIADTVNSKPGQNRMFVRFFSESKGKKTLFQANFTAFRDLGQGKNQKCNEEIEYDCDDATCIDRKLMCNKKYNCRFRWDEEDDECQTAQSMTWSGDHIIIIMVIFTLILTGMCMTFIYNCVTKLIRDHRTIQSDFVLKKGIIFLDCNLERIKPSLDSGPQTSADASVTNLTVLSTDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5G3</accession>
    <name>A0ABM5K5G3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505432.1">
        <property type="nucleotide sequence ID" value="XM_050649475.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649475.1">
        <property type="protein sequence ID" value="XP_050505432.1"/>
        <property type="gene ID" value="LOC126883805"/>
    </dbReference>
    <dbReference type="GeneID" id="126883805"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="40356" checksum="827BD62FFCEDCF62" modified="2025-10-08" version="1">MEYSKPPESFNVNEPQGWTKWKQKFEIFLLASGRSEAAEKIKVALLLNILGESCLDIFNTFPENKRDNFDDVISCFDNHFLPKQNICMETFKFNNIQQKEGQGIDSFLTELKKQAANCGFICEKDNCKQSYADRMIKDRMVLGVLDKQVQRHLLRETTVTLDKMQEYCRSIEVTLKHVELLNTKEETEEINAVKFKFTRNCIRCDTKHEVRKCPAYNQTCEICNRKGHFSNLCFWKNKQRNDEQPSSSNEQGKKASEVQKNVKIQETNCVETEVDGFDNNDEKIEEESIFIFEQKQDSNKASSTNKLEVFEMRCLHRMLKISWAYLGTYCEEKDILVGNWNSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6I2</accession>
    <name>A0ABM5K6I2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505803.1">
        <property type="nucleotide sequence ID" value="XM_050649846.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649846.1">
        <property type="protein sequence ID" value="XP_050505803.1"/>
        <property type="gene ID" value="LOC114344824"/>
    </dbReference>
    <dbReference type="GeneID" id="114344824"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="361" mass="40363" checksum="AC109EC9D0EBA0FC" modified="2025-10-08" version="1">MSKSATKLACVNDYEDYARKHLSTMYFDYFYDGAGQGKTLEWNKTGFNIYRIRPKYMRPVINRNLSTTILGKPVSFPIGISPTAYHKLAHRDGEPATAKAAQDLETIFILSSHSNSTFEEVSNAAPHGRKWLQLYIFHSREMTKDLVKSAEENGFEALVLTVDFTLFGIRRHLIRTEFIMPPYSQSILLKKYIDNNIISNYVDLGDLQADWSYITWLKTVTKLPIVVKGVLTAEDAIAAVDAGASAIFVSNHGARQLDSVPSTIEALPEVVKAVGHITEVYMDGGIRDGTDVYKALALGARMVFVGRPVVWGLFHDGEQGVKNILKMLKEELDNAMGISGCSKLTDVNQDRVVHKNYYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8N3</accession>
    <name>A0ABM5K8N3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506549.1">
        <property type="nucleotide sequence ID" value="XM_050650592.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650592.1">
        <property type="protein sequence ID" value="XP_050506549.1"/>
        <property type="gene ID" value="LOC126884596"/>
    </dbReference>
    <dbReference type="GeneID" id="126884596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="369"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="936" mass="107742" checksum="7E7EC7E08F4E26FE" modified="2025-10-08" version="1">MKIKKNNFQSGNSNHYNVEDEMDNYEEPKQWYEEIQEDPKSFSKSTEQVLIELKDEAKKCHDSEVLHYNTKNSKTNSDFQWMKTVMSKGTLSDKIAAHTVMIQDNPVACLDTIRNLVGMVKVGKKKECTTVMETLTELFLSNLLIPNRKLKAFHQRPLSALNELSSGNAVSRRKILSYWYFEDQLKEIYATFVVALNAVAHDTVDSNKDKAVTALYKLLVDNSEQEKNLLTYIINKLGDPSQKIASKVIYCLTQLLYKHVNMQLVVLNEIEKLLFRPNISTRAQYYSLCFLSQFHLSHETSHIARKLIEVYFSFFKACVKTGDIDSRMMSALLMGLNRAYPYAKLEYDKVQEHVDTMYRLVHMANFNISLHTLTLLYQVSDTGTGVTDRFYGALYRKLLDPSLLTTTHRAMLLSLIYKALLKDKEINRIKMFVKRLLQIALFTQPCFSCGILFLVSQLMNKKKDLQALTLKQSAPISFEDDDDEEKYQDVKEENEEIPEIKEEVDDEEFKKLEQNQSTPSINAMVETIEIKEEDEDIKPDVEILNASLNNSAGWYHCKNTVKKEKGAVIKYNPLSRNPLYGGGEFCAYTELYNLKNHFHPTVALFASNIINGETVAYNGDPLNDFTLIRFLERFVFKNPKRVSEASGRDSTFGKRKLYRPKGVKAMSVKTASYAKESSENIPVDELFVHTYLQQRYQERGETERDDSDLESVQSDEFEEMLDKLSGRKDGEEEDEEDVDYLNEIGENLRQKDSKKKKKQKSEDDEDDSDDISEEDDDDMDDFDGEFDNADLDDEDLDMNDDDKELLGDLSDEEDDEAIDFSDEEEQPGKNKFKKFAKKKGDIMSNFASAEEFATLLEDEGSSKFKPGGSNAFANKDNANVKQLAWEENRNRWLNNFSRTMGGGKGKKFNKSNNNKNFSKKRSNHNKGGNQNKKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9J0</accession>
    <name>A0ABM5K9J0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate [NMDA] receptor subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a heteromeric NMDA channel with Nmdar2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506853.1">
        <property type="nucleotide sequence ID" value="XM_050650896.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650896.1">
        <property type="protein sequence ID" value="XP_050506853.1"/>
        <property type="gene ID" value="LOC114331106"/>
    </dbReference>
    <dbReference type="GeneID" id="114331106"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06379">
        <property type="entry name" value="PBP1_iGluR_NMDA_NR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13719">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018882">
        <property type="entry name" value="CaM-bd_C0_NMDA_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049872">
        <property type="entry name" value="NMDA1-like_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049873">
        <property type="entry name" value="NMDA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10562">
        <property type="entry name" value="CaM_bdg_C0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="20" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 26" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046648262" description="Glutamate [NMDA] receptor subunit 1" evidence="26">
        <location>
            <begin position="22"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="27">
        <location>
            <begin position="412"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="28">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00024675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="954" mass="107454" checksum="EDA5749DB0DBB9A4" modified="2025-10-08" version="1">MLLKVVIYGLICCCFLSFLKANPRDWPNPTVFNIGGVLSSNESEKYFQETIAHLNFDSQYVPKGVTYYHTAILMDPNPIRTALNVCKYLISRKVYAVVVSHPLIGDLSPAAVSYTSGFYHIPVIGISSRDSAFSDKNIHVSFLRTVPPYSHQADVWVEMLKHFKYKKVIFIHSSDTDGRALLGRFQTTSQSLEDDVDIKVQVESVIEFESGLDSFRDQLLELKNAQSRVYLMYASKNDAKIIFRDAAAFNMTDAGFAWIVTEQALEADNIPEGILGLKLVNATNEKAHIRDSIYVLASALRDMNQTKEITEAPEDCDNSGSIWDTGRDLFNFIRKQVLINGETGKVAFDDQGDRINAEYNIVNIQRKKKKVVVGKYFFNKELNKMNLKVDENSIIWPGRQTEKPEGIEIPTHLKVLTIEEKPFVYVRKLTELQETCNPDEIECPHFNTTFEEITSVYCCRGYCIDLLKELSKKINFTYSLALSPDGQFGNYLIRNVSGSGKKEWTGLIGELVADRAAMIVAPLTINPERAEFIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLANTDGTEEDALNLSSAIWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLTGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYDTAEIAIQDVKEGKLMAFIWDSSRLEFEAAQDCELVTAGELFGRSGYGIGLQKGSPWSDDVTLAILDFHESGFMESLDNKWILQGNFQQCEQFEKTPNTLGLKNMAGVFILVGAGIVGGIGLIVIEMAYKKHQIKKQKRMELARHAADKWRGAVEKRKTLRASSTAQRRIKSNGVNEAVTISHVFDKFQRIGMYPERTWPGDSDVRQRRMDDVGGGIQPVPRYLPSYTQDVSHLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA05</accession>
    <name>A0ABM5KA05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507019.1">
        <property type="nucleotide sequence ID" value="XM_050651062.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651062.1">
        <property type="protein sequence ID" value="XP_050507019.1"/>
        <property type="gene ID" value="LOC126884816"/>
    </dbReference>
    <dbReference type="GeneID" id="126884816"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009738">
        <property type="entry name" value="BAT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033184">
        <property type="entry name" value="PRRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038">
        <property type="entry name" value="BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14038:SF0">
        <property type="entry name" value="LP18708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07001">
        <property type="entry name" value="BAT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAT2 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1608"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1797"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2022"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2113"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1807"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2034"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2126"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2169"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2181"/>
            <end position="2196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2196" mass="244867" checksum="30BE8D289D4F7316" modified="2025-10-08" version="1">MSTLPGQASKGEKTKSKFQSLDINNLYRVSRGENLEKQQQKSSSVYIKHGMQSLGKVPNARRAPANLPSLKAEHSGTDAAVPLVPPGAPGWGKQDTSATGTSQSPNNNHQTVAQSQDSNVPPLNAPNQTGVSPQLSSHQAAIALPVTNTIPPQTHKQLTPTAQPVPTDKLWSSVMTGPESHPPLYQSVQFQHEFPSLSSGDGAPTRTGSDAPQYPSGLSLRPQTEGSWTQGGQRPMGPPGVTGGDAAGQGRPGSAHLGPPPQLSAQAGHQQQPFPPQIRGVMPPFMYKGSNFQPASGIGIQNPQTMPQPNNGRGNRQVDNRPPRLADRETDEVAPRPIIREEELSRMDEMSKDMGWAESDEIDYNQKLAFSDDEGEKSSKREHKKSSMNRDHRDDRESHNADSQNRQWSGGMRSNAPRGRNSEDEDIWVQRRTQQDKEVEIAVQRAKQRKEEEEKRFNEERKQAAQKKLMELEEKIQKRDRDNHEGVGTINPNTVPAKPINHVDIPLPDFQKDKERDREPPREKDSRSRTPNESSDDKNQASNQGNSFRQLTQIEGKNFPPRKQHAKPERDNRDNREQNGPNFSRQFQNDLPPRFRNNSNSNLQNHQQYHQQSFDNRWSSGNSRTKSQSNSSHGSMHNRNIRQDSPEIEKEDLDRKEYKRQSSDDSYRSSHHSEQERDSQDSRYHHSDNSDSRHQDYDMQYSRREQEHDKWHKEKNIQDNKKQDDQSHRSSNEDWSERPEKVREEKVVDKYEKERERDRPQRPDSRDSRDSRSTRHSRDSEPREYNMGSWSESMYEHPYEDKRKDYSREERRSVPGPITKDRMEADDMRNEKRNLTQLKRGQVVEVKSEIKKELPTKVIPLKMEFASAWADAQPLALEEAESKMTEDKRQSESKVEIKSPEQSKKSDKTDDYNQNRNRSYGQKKGWNTNDNHSSRGPPWPRRPSSRGQKPGGRNQDYHTADSDGSLEDHSGNLKADDGRKADTTKHELSEQRSPKPARKNEKDERNREHKQDKYGNEKRQDKQDRKDNNYVPRGEPSRHGRGGGNFRSGRMGGLSKRIDGYGPPPTKSPFGGHQDEREKDKKSVEDSSTPENVNPVEDKIKQNQQALAAGIIGKRSESPPTPEERNREMRDNRDGKPRNKTDNRKNKPKVEEKLSDSNAEGSDDKNKDNRKNPLKLQGNRSSSNSNRGRNNPPRMGGEKRYEGGRGEHMRQNSNNSLKKDDKPVEHNLFANALADIAPKNRDEPDHAEEKEERVSVNGDAEGFQEVKSKKNVKERQKSFDEKSSKPLKTENVKDVKPERERERERDRDRERDRDRKKISPPTQQLTQQQISNIPPLMATPVNPPPVLPQAKAQFDRPRQTNLPPRFAKQKLQKQQQQKQQQQQQQHHGLGDVNDINKMNQNMNVYSMKEASVPPAVPTCAWDKPLGSQLRNVEHDAMLGVTIDGVKGLESTHSPTQGVSPGGEKVIGKTTQIQEKALLDGSTPPVNTIIFENTNFKSAPGARQVRNDKPRPKMEEGNMDPSVMSGFNKPNMNELLPQKAEKTDAIQLPLFKEDPPDMKLDFFSADLQFADDKAAKNFVSKSLHAITSGNNTVDSLDIKIASVKKVWETSEQEGEDSQISFGGPPLDTNVFNQGKDTPDDNHEGYSPSPNQSAATTNVCKVKPTQQVSGSGQTVLSSSGHQPHSGIVATGLMGNPLSPPPIPPVLGASVGMGPQYTANQHISYQASLSGNTQYGISAIPSPPTVPLVYNSTQQIQAAAAQTAGLYGAFQIDQLGGQGRSQFSQYPNYHSLGQTANSPYSTQSVYLPTAAPPPHPPPPTAPGPPELYPNMSNYRLSATFGQTQPLNNPTTVLISSTSNSLMSASVKPSSQPISAIGTKAGGVGQAYQQQSQQSQQVFIPYDPSIQANYLASSAGVMQRAPVPPAQNNVVPGLQPSSSFYSGSTGAQTGYYQQPGSSTMGSAQLQQHQAGYGLQGNVFGTHSQSHTNTGLQNFNSHSHFLTTPIQVAAALTAQQQFRSGLPAYMKGVGNQPLGDQTGRPQQLKSPSSQEVLSSVFNSGPQIPSPKSRQNNKHPPPQSSPTAQHKYNLYQGVGGQQNPNMQRYPAPIQRPVNFQQMQQTNSVNQKHRSNSNKTPNRQYYGNQNQNEKSDDGKITENASLNSNNSSGGGKATLGANTGSSVNVPTEKVKDNIKEETAALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAY0</accession>
    <name>A0ABM5KAY0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507343.1">
        <property type="nucleotide sequence ID" value="XM_050651386.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651386.1">
        <property type="protein sequence ID" value="XP_050507343.1"/>
        <property type="gene ID" value="LOC126884998"/>
    </dbReference>
    <dbReference type="GeneID" id="126884998"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045277087" evidence="1">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="222" mass="25160" checksum="C81C0CC2AFD9FC91" modified="2025-10-08" version="1">MVRALHILATLLAVQLSYGNPQPGYPVDPHCPPEDCEPYPVHCPYPIPEPVCEIPVIPPPHYPHPIPDCDYPYPGYPHGPINPGPLPPHLPLPPHLPIPKPCDGLPGAWPNEWPCYFPCGWPDDWPCDFPLGLPNNWPIDFPHGLPHDWPNHFPHGWLPDNLPHGYPNAWPCDWPENWRDYWPDCWPNYWNDCELPIPLPHGHGYPHGPYPGPGPYPCPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBS1</accession>
    <name>A0ABM5KBS1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507639.1">
        <property type="nucleotide sequence ID" value="XM_050651682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507640.1">
        <property type="nucleotide sequence ID" value="XM_050651683.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651682.1">
        <property type="protein sequence ID" value="XP_050507639.1"/>
        <property type="gene ID" value="LOC114328549"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651683.1">
        <property type="protein sequence ID" value="XP_050507640.1"/>
        <property type="gene ID" value="LOC114328549"/>
    </dbReference>
    <dbReference type="GeneID" id="114328549"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="127982" checksum="6C0EA10BAE00089E" modified="2025-10-08" version="1">MLRIKFKKKMSEFAEKDSGAALSKVISLEVNINKVEIGNGSSYIKLPEQIQKRQACINIKNYDQNCFYWAIISSLYPAKIHKELTSSYPYYSTVLKTEDMEAPMPLSHITKFEKINSISVNVYALELNQVKEKQFYDVVPARLTQNKLDRHVNLLLIQDKYFPNLNDYDAPPSDDENIEIKYHYCWIKDMSRLVSSQVSKNKSKKYICDRCMNYFYSGNKLAEHEEFCRDINKCKMTVPKYDYVAFRNFTYKQTTPFIIYADFECQLHNFTDSNVNLSKTTKYQKHVPYSAGYYLKCAYDDSLSYFRSYRGENCMEWFAKEMAEISKFVDSKIKSIVPMVTKPSTSEATACHICEKRFLATDIIVVDHDHFTGEVRGFAHQACNLNFRKVFVVPVAFHNFSGYDSHFMIIDLCKHGHLSLLPINKEKYISFTLHSDEHKIRLRFIDTMRFMGTSLDELASLLDTSEKKILKQEFNSLDDNAFNLLTCKGVFCYDYVDSLEKLEETSLPTISHFYNKLCDEHISEQKYAHAQKVWSIFECKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYHLDPAWYYTIPGYTWDCMLRYTKCRLELLKDVDMILFIEKGIRGGISVCSNRFSEANNKYMPTYDPTQPSKYIMYLDVNNLYGWAMSEYLPFGGFKWIEDVTKFGVASKSTKLPKGHIDIMSIPNAAKEGYFFQVDLEYPRELHDKHKDFPFAAEHRIPPGSKLPKLLPTLFNKSKYIIHYRNLKQALSNGLILTKIHKVLKFNQSAWLRPYIELNTNLRAASKSSFEKNLYKMMNNAVFGKTMENIRRHRTVKICKNWNGRYGAKNLIASIRFHSRTIFSENLVAIELTKSVVCFNKPLYIGAAILDISKLCMYDFHYSFMLPTMGEENCMLLYMDTDSFIYELQCLDAYKEVLKAHNCKFDTSDYSENNPYMIERLNKKIPGLMKDEANGKIITHFIGLRSKMYTFKLQTTDEERENERERLKLKLNKEQIDCGIQNLGITKKAKGVKYNVVKNIITFEDFENCLKEYKIKSTNQRCIRSYQHSVFSIEQTKTALSPYDDKRYLIPESFKTLPWGHCDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC63</accession>
    <name>A0ABM5KC63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507781.1">
        <property type="nucleotide sequence ID" value="XM_050651824.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651824.1">
        <property type="protein sequence ID" value="XP_050507781.1"/>
        <property type="gene ID" value="LOC114332363"/>
    </dbReference>
    <dbReference type="GeneID" id="114332363"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14782">
        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013684">
        <property type="entry name" value="BBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="10">
        <location>
            <begin position="166"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="9">
        <location>
            <begin position="395"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="11">
        <location>
            <begin position="493"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="12">
        <location>
            <begin position="586"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR013684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="717" mass="80422" checksum="49E3C416780E7388" modified="2025-10-08" version="1">MDKIVRPVFTLELNYKIVPGLVTIGKYDGTHPCITAATTTDKVLIHSPHRRNNSTTGRVFWSESNKEIANLNINQTITCLTVGVILPDDEKDILLIGTSTHILAYHVHDNKDVLYKECPDGVKSIAVGSFKDIKNVIMVGGNSSVHGYNNQGTEIFWTAVGDIATSLIFMDYNQDGQNELIVSSEDFNIRIFDKDRMLAEHVETEVVTNLLALPENRFAYSVSNGTVGVYEQEVRLWRVKSKHFAISLHYYDLLGQGTPQLVTGWSNGKVDFRSIKTGEVLFKDTMSSGVSGVVEGDYRSIGKNDLICISSEGEVKGYTTTKVLTTNKGSESDQNLIRELLAQKQSLLMELKHYDVNTKYNENIFYETESYENSGVIPANTRLELAISTNSTDPKPHVELYLCTNNSTIIRATIIFAEGIFSGETHVIHPPVSKLKSQLLVPLFLPKDSPVDIHVKVLIGYPNSCQFHVYEITRQLPRFSMYSLKEPGRNSRSDSYVEFKINERLQRICMWINQNFLLPNDIEFDSGPNLTLSLKCLRNDTDLDLVFEISGKITIYTSNISLAADIIQSIAAYLNIGNLESSASFPQEEEKVSTLMGKLQDIQNARLRLETDVADRTSQIRALIVQADDCRINNLNALPDQYKELMTINAELINGYNIRLQNYNEGVETMKTLNSIIQKASRLRVGSKSSNMINFCRTCLNNNSAEGLLKVIKTGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCP2</accession>
    <name>A0ABM5KCP2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507945.1">
        <property type="nucleotide sequence ID" value="XM_050651988.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651988.1">
        <property type="protein sequence ID" value="XP_050507945.1"/>
        <property type="gene ID" value="LOC126885419"/>
    </dbReference>
    <dbReference type="GeneID" id="126885419"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="394" mass="45482" checksum="DBF3FB8AAA6BF716" modified="2025-10-08" version="1">MPKRHYIRRQVHQQEPHIFDLYQKPRFDDTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFAIHDTLLEIKGSIKKAGNGTVSLAPNAGSFLFDTCTYIQSSHDMEIVRDPGVVSTIRSLLCYTPEDSKFLSTAGWNYPNYPHLTGDAFSLLIPIKHIFNIFNDYTKLTYGRQVFRFVRARNDKDCIVVQEPTGSTTVTTVSLTIASMELKVKHVFPNDDVKIELMTPIKDNTPITIPFRKWELNELPSLTAGSRREIWSVKTTSAVERPRYVIVAFQTSKRDDIHADPTLFDHIRMSSVRVVINGDYWPNERMQLDFTKNDYAIAHYNYTEFFVFDCSKQDDTSFRSGTVDVKLEIEADEGFPAGTRAYCLIVHDSLLEYFPLTEVVKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD03</accession>
    <name>A0ABM5KD03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508072.1">
        <property type="nucleotide sequence ID" value="XM_050652115.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652115.1">
        <property type="protein sequence ID" value="XP_050508072.1"/>
        <property type="gene ID" value="LOC126885533"/>
    </dbReference>
    <dbReference type="GeneID" id="126885533"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="75656" checksum="8378C4FAA5E89435" modified="2025-10-08" version="1">MGASLDELASILDTSEKKILKREFSNLDDDTFNLLTCKGVFCYDYIDSVEKLDETSLPNIRHFYNKLNNEYISEEKYAHAQNVWNKFNCKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYKLDPAWYYTMPGYTWDCMLRYTKCKLELLKDVDMILFMEKAIRGGISVCSNRYSEANNKYMSTYDPTQPSKYIMYLDVNNLYGWAMSEALPIGGFKWIEDGTKFGVASKSTNLPEGHIDIMSIPNDAKEGYFFQVDLEYPRELHDKHKDFPFAAEHRIPPGSKLPKLIPTLYHKTKYIIHYRNLKQALENGLILTKIHRVLKFKQSAWLRPYIELNTNLRTAATSSFEKNLFKLMNNAVFGKTMENIRRHRIVKLCKKWHGRYGAKNLIASSRFHSRTIFHENLVAIELKKSEVCFNKPLYIGAAILDISKLCMYDFHYNFMLPTMGEENCSLLYMDTDSFIYELQCSDAYREVLKAYPSKFDTSDYAENNPYDIERLNKKIPGLMKNEANGKIITHFIGLRSKMYTFKMQITDVEREKERQRLERKQLNKERIESDVSNLGITKKAKGVKYNVVRNKITYEDYEKCLKEFKIQNASQRCIRSYQHSVFSIEQSKTALSPYDDKRYLIPKSFNTLPWGHYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD46</accession>
    <name>A0ABM5KD46_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050508112.1">
        <property type="nucleotide sequence ID" value="XM_050652155.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652155.1">
        <property type="protein sequence ID" value="XP_050508112.1"/>
        <property type="gene ID" value="LOC126885567"/>
    </dbReference>
    <dbReference type="GeneID" id="126885567"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="18">
        <location>
            <begin position="285"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="578" mass="65346" checksum="399D455CE852365D" modified="2025-10-08" version="1">MSLELFFFTRAILSNPDLLSKTPWVRLLENDFWGTPLSDSGSHGSYRPLCVLTFRLNYLLGGFQPWGYHLVNVLLHCLATVLLIRVARLILPKAKSSVGSMVTGLVFATHPIHTEAVAGVVGRADLAACNFYFLSLLAYVAHVRCRETQYCHRFCKKSSVIKSDSKQYQKIVYALHKSVTSCNWPKRQLRDLENTELSSVSVVMKKRDNVRSCCWKNNLKLWIYLVLCLLLAIAAMLSKETGITVLGICFVYDLVYCIPSSKKQARSLLILASALSIILAARLQSRTPHFSSADNPTARETELVTRFFTFCYLPVFNFWLLIFPNHLSFDWGMEALPRITTIRDSRNVISLVFYYGLAHILRKSLSRIRKKDRRGVRNKEDNNCCTVCHINCSDVHSSSCRTSNNNNTTNFSSSLCVCYNFCRPLVVLRTEKKQHNSNSAIVLSFAFLALPFLPATNILFYVGFVVAERVLYLPSAGLCLLLGLASGTLWECYKRQRPLFLCGLVLVSVAFSAKTVFRNKDWHSEEALYRSAIPINPPKAYGNLGSVLSSQGRVDEAETAFRKALQYRPNMADVHYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDL0</accession>
    <name>A0ABM5KDL0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear respiratory factor 1 NLS/DNA-binding dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508280.1">
        <property type="nucleotide sequence ID" value="XM_050652323.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652323.1">
        <property type="protein sequence ID" value="XP_050508280.1"/>
        <property type="gene ID" value="LOC114332830"/>
    </dbReference>
    <dbReference type="GeneID" id="114332830"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="7">
        <location>
            <begin position="52"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="423" mass="47054" checksum="F4FE0924544562A2" modified="2025-10-08" version="1">MNNSKENQNAETQSFASVVSDNDDCMSAYEEESDITAAVERDKVTAQLAAAGPVGVAAAAAIVSARKREKLHSFETNPMIRKRQETRLLMNLGKTIDEFAIRVGKQAVVLVATPNSYNVFGAKPLEDVIRNHRDMIMDDLDNALAAHALPLIKQEPLLFDLPPLIIDGIPTPLAKFSQAQLRAFIPLMLKFSTGRGKPGWSRESMRPLWWPEQLPWANIRMDCRSAEEKEKISWTHALRQVVINCYKFHGREDLLLEFPEEDKKINQATKAEADATMQCTPTVLHPITNSDGIYTAVQVDPNNPIITLPDSTTTNFHFMVMGDGNQVHYIQTITDGGPMGEYINLNSVTKATLNSEGHITLTREDGHVSSIIKVPAPDYCSMVAKLQAFQTNSDGTIFATRIFELLKEEHDSNNNGHVNTNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFE9</accession>
    <name>A0ABM5KFE9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508926.1">
        <property type="nucleotide sequence ID" value="XM_050652969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652969.1">
        <property type="protein sequence ID" value="XP_050508926.1"/>
        <property type="gene ID" value="LOC126886125"/>
    </dbReference>
    <dbReference type="GeneID" id="126886125"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="363" mass="41507" checksum="ADD28A3450C36810" modified="2025-10-08" version="1">MLAPRHKNNINLIEKELCALKNKFQNDQIMLTEVNNLSSRIENISRRKVEYKDTDFGPFLIMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMVLNSTEILEKGFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNVKIISARRLNRRVLDSSGTVTYVPTGTVQLLFDVRTPPKEIIIYSNLVTVDPYIPPVQQCFKCLRFGHSQRQCRGKARCPKCSDEHTVQSCTVSVPKCLYCDLDHLATNKICKEFERQKKINEVMVFQDLTFFEAAKLFPPIKEKPENSRMFQRRSRDFPSLLSSSPRAFTQALQKSPSSTPLFQSQSHVVPVKRKNKVYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFP0</accession>
    <name>A0ABM5KFP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509005.1">
        <property type="nucleotide sequence ID" value="XM_050653048.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653048.1">
        <property type="protein sequence ID" value="XP_050509005.1"/>
        <property type="gene ID" value="LOC114335767"/>
    </dbReference>
    <dbReference type="GeneID" id="114335767"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="3"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="391" mass="43879" checksum="DE0A725CE62EA8A4" modified="2025-10-08" version="1">MTGNVFVIAAILLERNLQNVANYLILSLAVADLLVACLVMPLGAVYEVSQEWTLGPELCDMWTSSDVLCCTASILHLVAIALDRYWAVTNIDYIHQRTSKRIGIMIFIIWLVSFFVCIAPLLGWKDPNWEVRLRDKKCIVSQDIYYQIFATASSFYLPLMVILILYWRIFQTARKRIRRRQVLSKNNEEGAKNPAAGGIAGGLAAASGTEGNASQTVEENENSGIAAAVVTVIGRPLPTISETTTAFTNISSNNSSPEKTSFANGLEADLPTTTECSVTYQPHHYPIKRKTRDGMDSKRERKAAKTLAIITGAFVLCWLPFFIMAVLLPINPNVFDKYLVSICLWLGYFNSTLNPIIYTIFSPEFRHAFKKILCGRNYARRNRHFGVRNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGC0</accession>
    <name>A0ABM5KGC0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050509246.1">
        <property type="nucleotide sequence ID" value="XM_050653289.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653289.1">
        <property type="protein sequence ID" value="XP_050509246.1"/>
        <property type="gene ID" value="LOC126886383"/>
    </dbReference>
    <dbReference type="GeneID" id="126886383"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="4"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="572" mass="64923" checksum="13CAAAE82EF3F59E" modified="2025-10-08" version="1">MSEELVVTTEIGKLRGKAQKDYHGDKFYSFSGVPYAKPPIGELRFKAPEPIESWEGVKDCTKEGWECPSLDIYFKHHIGNEDNCLNMNIYTKELPSHNPNMKKRPVMVFIHGGGFIYGSNKSMHVGPNYLMTGDIVLVCINYRLGVFGFLSLEDQSLGVPGNAGLKDQTMALKWIQKHIANFGGDPNNVTIFGESAGSASVHFLLVSPLTKGLFHKAIMQSGCAFNPWAKGRRNFAVISKAMGYKDVDEKTLFQKLCRASTRSLVTASFKIEDSFFASIVRPFIPVVEYPHEGAFLTEDPEEIMKAGRHHHVPVIIGYNSMEGLMYELIRKTRTDADLPETLERDIPFDLNIPEKTERAKEVAEKMQKFYYQDKDLSEKNINNRYRMVSDVHFLYGIQKTITLLQRHSKAPVYVYRMSIISNLNFFKKFCEVKYLKTMLALSLLTKLSGGSSMKNVFQSLREKLPVRQIEGVSHADDIFYLFSTFLAPTIAKGSVEDRNIQKFVKPWTTFAECGNPTPEPTELLDHVVWSPVKDESISNIFDINDRISITGNVEAERIQFWRELYAECCGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGP6</accession>
    <name>A0ABM5KGP6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Regulator of telomere elongation helicase 1 homolog</fullName>
            <ecNumber evidence="15">5.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_050509376.1">
        <property type="nucleotide sequence ID" value="XM_050653419.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653419.1">
        <property type="protein sequence ID" value="XP_050509376.1"/>
        <property type="gene ID" value="LOC126886468"/>
    </dbReference>
    <dbReference type="GeneID" id="126886468"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03065">
        <property type="entry name" value="RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23116">
        <property type="entry name" value="HHD_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0408">Iron</keyword>
    <keyword evidence="10 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="902" mass="101940" checksum="FB3099C670B15C8B" modified="2025-10-08" version="1">MATVTIRGVPISFPFEPYEIQKEYMDKVLECLQNETNGVLESPTGTGKTLSLLCSTLAWLQLKKAQVQAQRQISMQENENEFLATINSKLNDIAGKQISSRALSGIPTVIYASRTHSQLSQAMQEMKKTAYSHMKAIVLGSRDQLCIHPEVEKEENRNFKIMMCQLKRKTRSCKFFNKVEAHSQNKNVLDINVMDIEDLIKLGKCNGFCPFYMSKELKDQADIIFMPYNYLIDPSIRTRLGINLSNTVVILDEAHNVERLCEESASLQIKSSDVALAIDEVTAIMKMLSSDQTVEFEDTPKDFDANDLCNLKEVFLNLEQAIDKIDLSSGQNSEVTLDGTFIFELLAEAGIRADNFFIIQKLINSIVQYLVTVNDGPFARRGNSLQIFEEILGVVFMDSSTEFKAKVKKCYKLYVQPEEVKKKTPDNWLSKMVSTKAGGKIINYWCFSPGFGMNMLMRHGLRTLILTSGTLAPLRPLISELELQINVRLENPHVISDDQFCVKIIPSGPDSENLNSNFQNRDNPKYINSLGMTIMNIARIVPDGMLIFFPSYPIMLKCQQMWQQSGVWNSICNQKAIFVEPRDKNSFNTAMTEYYAKVKDPAYKGAIFMGVCRGKVSEGLDFVDANGRAVLITGLPYPPFKDPKVSLKKLYLDRCNADDKGYLRGQEWYNLEASRAVNQAIGRVIRHKDDYGAILLLDSRFNSKVIKDQMSLWVRNHIRVSNNFGELVRDLRQFFRNADSKYKSVLEAKSLAPPSAEFNTHLNYKSGGLSASSSSDNLDSTGEVVIHNRTSKEDRKHPAKKIKLTVVPNSSKSAKQEQGDVTKAYIIMVRKNLDDTSFKAFVEAIQNYKAVSELGSLTSSLDAIFKTKSHLKYLIPGLESYIKVDHKSDFSNYCRKNGFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHW0</accession>
    <name>A0ABM5KHW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glucosylceramidase</fullName>
            <ecNumber evidence="3 6">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="3 6"/>
    <dbReference type="RefSeq" id="XP_050509801.1">
        <property type="nucleotide sequence ID" value="XM_050653844.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653844.1">
        <property type="protein sequence ID" value="XP_050509801.1"/>
        <property type="gene ID" value="LOC126886792"/>
    </dbReference>
    <dbReference type="GeneID" id="126886792"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433284" description="Glucosylceramidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="8">
        <location>
            <begin position="140"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="9">
        <location>
            <begin position="487"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="553" mass="63265" checksum="4C45F0DDF49E9690" modified="2025-10-08" version="1">MYTSVKALLLFHVLIRGVPFVVSRNCVPKELEPDKIVCVCTDTYCDVLEPVEKLPPTEYAVYTSNRDGERFSKKISYFTRPIVFTNCTVPNSDRACEHNVHVDYVLCSQNQKKNVQESIDAKKAEKKIYINPETRYQEIFGFGGAFTDSTGINIKNMSPELQDYVIRSYFSDEGLEYNLGRVPMGGTDFSDHYYSYMDSDEEDLNCIDPKLRQMQLAPEDFEYKIPIIQEALNIAKDLKLITSTWTIPKAFKESNLYRGTMGFVIDELYQLLADYYVKFLDLYSKYGISFWGISTGNKPFLAMAEIVGVPAVFWFPDDLSLWIRENLGPTIRKSAFKNIKMLTLDDQRPLLQILPKVLAHYKTLDYIDGIALQSYFDYANNTYLLDRTHTLYPHKFMLSTEAAVGSKYTGAATMGDWANGELYATDIIQDFNHWVTGWIDYNMVLDTEGGPTLSDPLIAPITSNVTEFYKEPQYYVLAHFSKFITRGSVRIYSSQCDADNLVQQTAFQRPDDGIVVVILNRNDFPVKRTLINCGKSDIKLSLSARSITTVVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHW8</accession>
    <name>A0ABM5KHW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050509785.1">
        <property type="nucleotide sequence ID" value="XM_050653828.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653828.1">
        <property type="protein sequence ID" value="XP_050509785.1"/>
        <property type="gene ID" value="LOC126886786"/>
    </dbReference>
    <dbReference type="GeneID" id="126886786"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044955482" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="482" mass="53482" checksum="F45147CD44BB2DDF" modified="2025-10-08" version="1">MIKLLVLLFGLALHVSCENPIVSLPNGQIRGRQVSAPAVENFKYYAFLGIPYAAPPIGKLRFQAPQPHNNWEGVFETTDNSKICIQVGLKHAHASEDCLYLNVYSPDLSPLQKLPVLVFIHGGTFRRGSAFGGYKAPAFLVKEGIVVVTINYRLGPFGFLTSQDNAMPGNYGLKDQHFALEWVHQNIHIFGGDPDQVTLSGQSAGAASVAFHIMNPKSEDLFRAAIAHSGSALNNWAYQHNGREIAYGIAAEIDPNFTRNKTTDELLEFLTNVPASDIEKTADKFSAFAPAIEVPNNDSVFSNLIYDAATMRLFNKVPLLIGINSEEAVFKAKDLHSLRKEAVGVDKDPSKLVTFEVLPYNDSMPSLVGNKIKDLYVGDQSFEENLGKYLQYFGDNRYMRPVIKFAELISTAANVYFYQFSYSGKLGGNDVSYPGIGKVAHGEDLNYLWVYHDDYTSFPDSDLIALRRYVQIVANFVKNLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI86</accession>
    <name>A0ABM5KI86_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498525.1">
        <property type="nucleotide sequence ID" value="XM_050642568.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507619.1">
        <property type="nucleotide sequence ID" value="XM_050651662.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509911.1">
        <property type="nucleotide sequence ID" value="XM_050653954.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509912.1">
        <property type="nucleotide sequence ID" value="XM_050653955.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509913.1">
        <property type="nucleotide sequence ID" value="XM_050653956.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509914.1">
        <property type="nucleotide sequence ID" value="XM_050653957.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642568.1">
        <property type="protein sequence ID" value="XP_050498525.1"/>
        <property type="gene ID" value="LOC126879506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651662.1">
        <property type="protein sequence ID" value="XP_050507619.1"/>
        <property type="gene ID" value="LOC126885210"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653954.1">
        <property type="protein sequence ID" value="XP_050509911.1"/>
        <property type="gene ID" value="LOC126886854"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653955.1">
        <property type="protein sequence ID" value="XP_050509912.1"/>
        <property type="gene ID" value="LOC126886854"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653956.1">
        <property type="protein sequence ID" value="XP_050509913.1"/>
        <property type="gene ID" value="LOC126886856"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653957.1">
        <property type="protein sequence ID" value="XP_050509914.1"/>
        <property type="gene ID" value="LOC126886857"/>
    </dbReference>
    <dbReference type="GeneID" id="126879506"/>
    <dbReference type="GeneID" id="126885210"/>
    <dbReference type="GeneID" id="126886854"/>
    <dbReference type="GeneID" id="126886856"/>
    <dbReference type="GeneID" id="126886857"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="315"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="815" mass="94463" checksum="04850C722B3BC935" modified="2025-10-08" version="1">MVVDFSKYLRLSKKRELLNIDIWFIHKCIKFKVTPTFAKCKVPSTATLNFKSQIERKFLQKELCKHHAHLDKINVQLKILYDNIVREVPFDNFRDSIANHLDNLEYIKQSKFNRVNNKLHNLIKKKNNLNSNSQNTNRLMGSFKFRFHKRTVNLSTCSFTNKELDFLSNGLKFSTLVPFNNKMVEEFSVDIDTVIESLPLDNISKTNLKSNCFLSLQKDLIKFNNNVNNIKTKCFKQLHLIRQLSFKLKSNNLIITKADKGNCLIIMHHSDYVQKTEEFLRNNNFDILDRNPLNKLITNLKNTLSKHKDFLQLHKTKEKTFILSNPQIPRLYGLPKIHKPNVPMRPVVSFYNTPVVTLSKFINSILQSTITLQPSYSVKNSTDLVNKLSVLNLPRDFFLVSFDVSNLFTNVPRDETIPLVEDLLIKSNINRVSIPHLLDLLKFCLSQDFFTFNDIIYRQAQGLAMGNPLSPLLADLFLNNLEVNIFDNNSSNQNSFQKILYWFRYVDDVLAIIDGNSTDAENILYLLNNLHPAINFTLETESNKSINFLDLTLTRMDSKLIFSVFRKPTQTDHTIPRSSNHPFQQKMASFYCYIHRLLSLPLSDTNFNSELDIIKQLAYSNGYSPTLVDNILNKLRSKRNRSLAYNPVLNNSTTAVMYRSISYIGYPSDNIAKILNNIPNLKLSFKCKENIKSIFSHTKDKIGKTSKSGIYKLSCGDCPVTYVGRTMRPLETRIKEHLSKIDKSSFGNHLHASKHNFSPQRDSRILHSIPINNYTKMNLLEDLEISRELKRNPQNCVNTQVQLNCKFDPIFKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KID5</accession>
    <name>A0ABM5KID5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509964.1">
        <property type="nucleotide sequence ID" value="XM_050654007.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654007.1">
        <property type="protein sequence ID" value="XP_050509964.1"/>
        <property type="gene ID" value="LOC114326164"/>
    </dbReference>
    <dbReference type="GeneID" id="114326164"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF465">
        <property type="entry name" value="AT17652P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045627042" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="69"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="201" mass="23300" checksum="F00C77003ACAD5D0" modified="2025-10-08" version="1">MAMNRNYVVLLLTLVGSVFLSATCLTCLKDGTPKVHGSAGSKLTGKQGVSQWENIFRNSKESVIPLRHWGNKSYWIGDAFQVPWYEAVTFCSQIHMQLLTITCEEENEQIFNYLKDAGKGFEYWTSGNRVIDQNKWLWLPYGKPVEYTKWSVGQPSDPVGEKCLQVWKIGEKLEWNDRPCWVPFYFICERYNYQNLASDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL24</accession>
    <name>A0ABM5KL24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050510853.1">
        <property type="nucleotide sequence ID" value="XM_050654896.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654896.1">
        <property type="protein sequence ID" value="XP_050510853.1"/>
        <property type="gene ID" value="LOC126887393"/>
    </dbReference>
    <dbReference type="GeneID" id="126887393"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="635" mass="74241" checksum="33E8FE09611BE538" modified="2025-10-08" version="1">MKVKQEFSEETCKIEIEYNDLDDALLDGFKCEIKEESNSQSTHGAYDSFDLKKCPIKTEIEQHGNELNPFEEKQETEKGCLQENKMEMMETLTEHSSHEENYINQHSEGKTLNKNVRVVTGKKPYKCEICFKQFSVAGSLKTHLKVHTGEKPHKCEICFKQFTNTSNLKVHLSVHTGEKPHNCEICFQQFRRGDYLKKHLRVHTGEKPHKCEICFQHFSRAHHLKSHLMSHTGAKPHKCEICFKQFSRVEYLNGHLRAHTGEKPHKCEICFKQFSYKSNLKPHLRLHTGEKPYKCEVCFKQFSYKSNLKPHLRLHTGEKPYKCEVCFKQFTHKISLDEHTKGHTGEKPYKCEICLKQFSQKVHLNSHLILHTGENPYKCEICFKQFTRTDNLKKHLRLHTGEKPHKCEICSKQFSEAGNLKGHLRVHTGEKPHKCEICLKRFTNSGDLKRHLRVHTGEKPYKCEVCFKQFTHKISLDEHTKGHTGEKPYKCEICLKQFSQKVHLNSHLILHTGENPYKCEICFKQFTRTDNLKKHLRLHTGEKPHKCEICSKQFSEAGTLKGHLRVHTGEKPHKCEICLKRFTNSGDLKRHLRVHTGEKPYKCEICFKQFSDASSLRTHLRVHTGEKPYSQKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KM64</accession>
    <name>A0ABM5KM64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511289.1">
        <property type="nucleotide sequence ID" value="XM_050655332.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655332.1">
        <property type="protein sequence ID" value="XP_050511289.1"/>
        <property type="gene ID" value="LOC126887685"/>
    </dbReference>
    <dbReference type="GeneID" id="126887685"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF55">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="142"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="48711" checksum="52DD327D46321A69" modified="2025-10-08" version="1">MNQSDCNFQYMTLPNLESLIAAHIGENQNIVDTNVTSLVGPGENYGGELFKIDVNIEDSKSKEKYQIHLVGKTIPKHEESQQVFKVQTTFKSEIAFYDRIVPALRKFQKENDVKEVIDCFPKYYGSRLNLNGSSVIDRDGVILLENLKISGYRNLDRYVCYNLAEAKILLKDLAEFQSTVVALKLKHPDVFKREVRHFCQNDIKAPRDQRFFHYILVIEDLLQKSDLCKPYISKIRDLWYENFSPDAESHPVREPFATISHRDLWVNNAMMKFDDNKAVKNKFIDFQIYDYGSPATDVLNFLLTSANTNATKNHFDYLLHHYHSEFVSNLKQLGCDPEPFNYSNFLKELELEAHAALTWAVGFVPVIVFGRKGESYTDTPTFDFEDRVFRKKLLANMMPEAKERLFYIVEEFIKKKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMI8</accession>
    <name>A0ABM5KMI8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMGB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511378.1">
        <property type="nucleotide sequence ID" value="XM_050655421.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655421.1">
        <property type="protein sequence ID" value="XP_050511378.1"/>
        <property type="gene ID" value="LOC114327707"/>
    </dbReference>
    <dbReference type="GeneID" id="114327707"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21978">
        <property type="entry name" value="HMG-box_HMGB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017967">
        <property type="entry name" value="HMG_boxA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00353">
        <property type="entry name" value="HMG_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="376"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="467"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="376"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="467"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="567" mass="66181" checksum="BB70DE42699D4274" modified="2025-10-08" version="1">MTTNNTIPGRRRLLKDFYRSVILSEKCAVTFLREHGLLDEADDNQPCHRCGSVMQQKTRSDRGKEARLVLRCPRKGCQVTRSVRTGNEYFHNFYTDLNDRVSSKLSLCGMLEIMFFFVEDIPLTTTVQLTGKATDTVTEWYNMFREICAAIVSSRDLMVGTIESPIQIDETRFDGYRKYKRKRKSEDGTGESEDSDDKEENHRNHGERIDGPWLFGLKNRTDCRYFFVERRDEETLVPIIQMEVASGSVINSDESPAYANLNELGFEHWTTTTVNHQRHFMDPVSETHTQRNERSALDAKIIMKKMRGVPRQDLQSHLNEYCWRILRKDEEDLFLTFLSDVKQGLVQALQQHQQILSQAPIPHKGRMPRAKADARPRGRMTAYAFFVQTCREEHKKKHPEENVVFAEFSKKCAERWKTMLDKEKKRFHEMAENDKKRYDTEMQSYTPPKGEKQRGKKRKQIKDPNAPKRSLSAFFWFSNDERGKVKAQNPEYGVGDIAKELGRRWAEADQEAKGKYEALADKDKARYEKEMTAYKKKNNPALQQVGHPVPEEDVDEEDEEVDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRZ6</accession>
    <name>A0ABM5KRZ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512967.1">
        <property type="nucleotide sequence ID" value="XM_050657010.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657010.1">
        <property type="protein sequence ID" value="XP_050512967.1"/>
        <property type="gene ID" value="LOC126888649"/>
    </dbReference>
    <dbReference type="GeneID" id="126888649"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="506"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="613" mass="70813" checksum="FF15290EE5D18576" modified="2025-10-08" version="1">MRLETNSSFTGMLLNESVEYTLDSYETPFVPELGYNDPCCSNNTEQNFVSEYLQSAQDEPIIIQELTSSSTVVQPTSWLSEYVESAEDEPKTIQELTSPSMSFQPEQHKNSNSTDGILFSEDQNSNLLVKPTNEDGSDDELIEDPHYIPESNTVLMTNENTTRKRRLERKRSRQQLEKLPDTRKARELRKKNRNSGKSYVTKKGKIIPERPFQTLPLCRAKCKTKITESQLKEIFSEYWSLGSYDKRAAYIASLFTIHDKKSHRPRTDDPDKEKYRLKTNKYFLRINGSHISVCRKCFLVTFNETDKFLKVIALKKRASPGETKTDSFQGKNIPLNKWSEKKLEEASKHILSFPSYESHYSRGQTNKKFLPSHLTLEAMCSLYKESHQNPVSYPYYRTEFHKLNLSFKKPQTDTCHKCDKFVMVLKCTDGADKESAAIEKENHIISAEQAYQAKKQDKLLAQKTKEMKCFTFDLQQCLPTPFLKSSVAFYKRQLWTFNLTVMDENGKSKHFMWHECTAKRGANEVGSCLYKVCLELPPEVTHVVLYSDTCGGQNKNSHISSMIMSILQRSDVNVQVVDHKFMVPGHTHMEVDVAHSMIEKKKEKIEYRNFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSD1</accession>
    <name>A0ABM5KSD1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513095.1">
        <property type="nucleotide sequence ID" value="XM_050657138.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657138.1">
        <property type="protein sequence ID" value="XP_050513095.1"/>
        <property type="gene ID" value="LOC126888738"/>
    </dbReference>
    <dbReference type="GeneID" id="126888738"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="89" mass="10144" checksum="864E8CDE5504E60B" modified="2025-10-08" version="1">MEFLKPYMKNRTTVGWPEVQQSEEIQSEQTEAQSEQTEAQSEQTEAQSEQTETQSEQTADITVPNDEGPNEAEEIECVQPEKKNCSQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSV9</accession>
    <name>A0ABM5KSV9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513279.1">
        <property type="nucleotide sequence ID" value="XM_050657322.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657322.1">
        <property type="protein sequence ID" value="XP_050513279.1"/>
        <property type="gene ID" value="LOC126888887"/>
    </dbReference>
    <dbReference type="GeneID" id="126888887"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF20">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15376" checksum="FCA0FBA8E0CC1B31" modified="2025-10-08" version="1">MYLIRFYQNYNRNICLVFLVSALECYSCDEENCKKESNHWQTVKCDKPADQNQEPVCQKLTYKSRGGIEQIQRKCAFALKNQDAPCPAILHQNEATELKCPTCKTNLCNSAITINFSLTALSATIFAILGRKLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT97</accession>
    <name>A0ABM5KT97_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513406.1">
        <property type="nucleotide sequence ID" value="XM_050657449.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657449.1">
        <property type="protein sequence ID" value="XP_050513406.1"/>
        <property type="gene ID" value="LOC126889302"/>
    </dbReference>
    <dbReference type="GeneID" id="126889302"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37664" checksum="75865275C6D8C98E" modified="2025-10-08" version="1">MVHLIIGALKEDEPGKPYLIAAEQLEKTNNVTVSRFIQQTLSAFFLPTEIKSEHFLIFLSDAAPYMVKVEQNLKIFYPNMVHVTCLLPGINRIAEVLRGEFDLVNKLISNVKKVFLKAPLRVQMYKEKLPGVNLPPEPVITRWGTWIKAAIFYANHFDAIKDVVLDIQNDSQCVTESQELLSNVQIAKELMFIKVNFSFLPDLIKSLEQRNLQLSDSGNLVNTFSAHCQKIPGNTGITIRNKLKNVLEKNEGFDCLRKVVSIFEGNFSEDLTTWQISLLPKLKYCLITSVDVERTFSVSTHVFSDRRQKLLVENFEKYLIINSYYNLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVN6</accession>
    <name>A0ABM5KVN6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514250.1">
        <property type="nucleotide sequence ID" value="XM_050658293.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658293.1">
        <property type="protein sequence ID" value="XP_050514250.1"/>
        <property type="gene ID" value="LOC114329870"/>
    </dbReference>
    <dbReference type="GeneID" id="114329870"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="912" mass="107588" checksum="61C47EBF9B6772D3" modified="2025-10-08" version="1">MVYESDFYTTRRPYRATPSVSSYTISGVPSRQVRVLPGLGKVHVTYTYDRIVPYVGHKRLTVVTAPPRVWGTRPSVLQREFDRIENKIRPWTGYSATNRYLNSNSAVRTYYVNYPITGSDYYDYYYSLNSPSTYYSPRLYRWYSSWPREYRTYWPMYRTYLSRYLRNYYQNLDWPSYYWSTYLPYTKNLDYEFSDIENKIDNLRKTIYLDYPYPIKAVDYTYYPQSYKSYTPLSLYYDYYWPLSSLNRYSSYWPYYPYHRYLYYKYTLPSDRYYHLKGVSISILVPCEIQKKMIFLRDPIRHITDYRIYPTTPKYLRHKVYKPLSLYCDYYDPIRSLFWDSSYWPLYKTTESFIDQCNQGTGDRLQRIFDDETRLIRAQTASLLKRIHDPVPRVQRYSWPAVAAKYDNGLPARLHNDNYIHRLLVTSPNSKTEYTTYYTEPVKKYIGAGHLAAVSYAGDRVYSRRPHIYLYEDPLKNDIQLLSYYINKFKQEKAITASSEPAKVPLNPARATRKFTAKRLEDDEEAAKEMQKLREARAARLAFINEEEKIERSSVAVDDAVKAKKKKEDERLAEEKALAEEQARREAQTKKEEAARKAELARQDELAAQAAAEKAAELERQAEQARKQELAKQAEIEKARKAEEERLRQEEQRRQEEEAKAEETRKQQERLEELARQAEEEKQAELARQAEELAELARQEAELAEQAKREAELAELARQEEELAELARQQAELEELERKEKELAELAEKAREEAEAAQREADEAARQQQEEEEQLVATTTADEADKAEEELAKQQAELEELAKQEEELAELERQQAELDALEAEAKALEAENEPQPEPEEEDEETQKQREMDELIQQKYELAELERQQAELDALEAEAKAMLGDDLEPAGAYDDEDEPAIAEDTPVHSDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXR4</accession>
    <name>A0ABM5KXR4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500678.1">
        <property type="nucleotide sequence ID" value="XM_050644721.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500814.1">
        <property type="nucleotide sequence ID" value="XM_050644857.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503512.1">
        <property type="nucleotide sequence ID" value="XM_050647555.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503514.1">
        <property type="nucleotide sequence ID" value="XM_050647557.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505346.1">
        <property type="nucleotide sequence ID" value="XM_050649389.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505469.1">
        <property type="nucleotide sequence ID" value="XM_050649512.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507854.1">
        <property type="nucleotide sequence ID" value="XM_050651897.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507989.1">
        <property type="nucleotide sequence ID" value="XM_050652032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508166.1">
        <property type="nucleotide sequence ID" value="XM_050652209.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512791.1">
        <property type="nucleotide sequence ID" value="XM_050656834.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512965.1">
        <property type="nucleotide sequence ID" value="XM_050657008.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512987.1">
        <property type="nucleotide sequence ID" value="XM_050657030.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513617.1">
        <property type="nucleotide sequence ID" value="XM_050657660.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513620.1">
        <property type="nucleotide sequence ID" value="XM_050657663.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514967.1">
        <property type="nucleotide sequence ID" value="XM_050659010.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515944.1">
        <property type="nucleotide sequence ID" value="XM_050659987.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516090.1">
        <property type="nucleotide sequence ID" value="XM_050660133.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516108.1">
        <property type="nucleotide sequence ID" value="XM_050660151.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516402.1">
        <property type="nucleotide sequence ID" value="XM_050660445.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516504.1">
        <property type="nucleotide sequence ID" value="XM_050660547.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518968.1">
        <property type="nucleotide sequence ID" value="XM_050663011.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644721.1">
        <property type="protein sequence ID" value="XP_050500678.1"/>
        <property type="gene ID" value="LOC126880668"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644857.1">
        <property type="protein sequence ID" value="XP_050500814.1"/>
        <property type="gene ID" value="LOC126880795"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647555.1">
        <property type="protein sequence ID" value="XP_050503512.1"/>
        <property type="gene ID" value="LOC126882582"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647557.1">
        <property type="protein sequence ID" value="XP_050503514.1"/>
        <property type="gene ID" value="LOC126882584"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649389.1">
        <property type="protein sequence ID" value="XP_050505346.1"/>
        <property type="gene ID" value="LOC126883726"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649512.1">
        <property type="protein sequence ID" value="XP_050505469.1"/>
        <property type="gene ID" value="LOC126883836"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651897.1">
        <property type="protein sequence ID" value="XP_050507854.1"/>
        <property type="gene ID" value="LOC126885340"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652032.1">
        <property type="protein sequence ID" value="XP_050507989.1"/>
        <property type="gene ID" value="LOC126885461"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652209.1">
        <property type="protein sequence ID" value="XP_050508166.1"/>
        <property type="gene ID" value="LOC126885606"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656834.1">
        <property type="protein sequence ID" value="XP_050512791.1"/>
        <property type="gene ID" value="LOC126888497"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657008.1">
        <property type="protein sequence ID" value="XP_050512965.1"/>
        <property type="gene ID" value="LOC126888648"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657030.1">
        <property type="protein sequence ID" value="XP_050512987.1"/>
        <property type="gene ID" value="LOC126888668"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657660.1">
        <property type="protein sequence ID" value="XP_050513617.1"/>
        <property type="gene ID" value="LOC126889402"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657663.1">
        <property type="protein sequence ID" value="XP_050513620.1"/>
        <property type="gene ID" value="LOC126889405"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659010.1">
        <property type="protein sequence ID" value="XP_050514967.1"/>
        <property type="gene ID" value="LOC126890159"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659987.1">
        <property type="protein sequence ID" value="XP_050515944.1"/>
        <property type="gene ID" value="LOC126890793"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660133.1">
        <property type="protein sequence ID" value="XP_050516090.1"/>
        <property type="gene ID" value="LOC126890958"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660151.1">
        <property type="protein sequence ID" value="XP_050516108.1"/>
        <property type="gene ID" value="LOC126890971"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660445.1">
        <property type="protein sequence ID" value="XP_050516402.1"/>
        <property type="gene ID" value="LOC126891265"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660547.1">
        <property type="protein sequence ID" value="XP_050516504.1"/>
        <property type="gene ID" value="LOC126891371"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663011.1">
        <property type="protein sequence ID" value="XP_050518968.1"/>
        <property type="gene ID" value="LOC126893069"/>
    </dbReference>
    <dbReference type="GeneID" id="126880668"/>
    <dbReference type="GeneID" id="126880795"/>
    <dbReference type="GeneID" id="126882582"/>
    <dbReference type="GeneID" id="126882584"/>
    <dbReference type="GeneID" id="126883726"/>
    <dbReference type="GeneID" id="126883836"/>
    <dbReference type="GeneID" id="126885340"/>
    <dbReference type="GeneID" id="126885461"/>
    <dbReference type="GeneID" id="126885606"/>
    <dbReference type="GeneID" id="126888497"/>
    <dbReference type="GeneID" id="126888648"/>
    <dbReference type="GeneID" id="126888668"/>
    <dbReference type="GeneID" id="126889402"/>
    <dbReference type="GeneID" id="126889405"/>
    <dbReference type="GeneID" id="126890159"/>
    <dbReference type="GeneID" id="126890793"/>
    <dbReference type="GeneID" id="126890958"/>
    <dbReference type="GeneID" id="126890971"/>
    <dbReference type="GeneID" id="126891265"/>
    <dbReference type="GeneID" id="126891371"/>
    <dbReference type="GeneID" id="126893069"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="420" mass="48532" checksum="59A99B02BAB8103A" modified="2025-10-08" version="1">MYGKRARSNNITMPPIFDIYRKPIFDESIRKAEYRTYAPFIKSFNCNDIVEFSINQVDSFFAMSETLLCIKGSLEITGNGGVKLANNVGAFLFDSCTYSESAREMETVRDPGIVSAVRAMTCYTQEDSNYMVMAGWNYPKDPILNAADHSFSIQMPLKHVFNIFNDYPLITCGRQTIRLVRARNDNDCIVITEKQNADKTTTVTTAKINITNIELRVKHIFPNDDIKLELMKSIQQDQPIVIPFRKWELHELPAITRGARREVWAVKTSTSVERPRYVIVFFQTNKRDKITADPTLFDNVNIQSIRLSLNGEYWPNERMQLDFSKTDYNEAYFNYTEFYPSYIHSQQKRPLLDFSAFKNRALFVIDCSKQEESMKASTVDVKLDIEANNGFPDNTKAYCIIIHDCVMEYFPLTEIVKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXX2</accession>
    <name>A0ABM5KXX2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515043.1">
        <property type="nucleotide sequence ID" value="XM_050659086.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659086.1">
        <property type="protein sequence ID" value="XP_050515043.1"/>
        <property type="gene ID" value="LOC126890232"/>
    </dbReference>
    <dbReference type="GeneID" id="126890232"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="324"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="854" mass="98196" checksum="074DEED413FD3EAF" modified="2025-10-08" version="1">MGFYNTIRVEYGEQSVRFLKDYQRTNLKLAKERNRRLFLLSCRSKGITPNHICHATTSVHNYIHRNEFWQLEGCQQLIRLDSKLLNVEIATNHKNLKKLENSLSLLKNNIIQSTSENIWLQFSHTQSINYNKLFFSIKSDNLRKIDTLYQSCCKTFLKTDPKWIKNLSTSIIPNDILGFLALGNKFSIEPKLGKDLQIKSLLADLEQIISSLPSELEQNSVRARSTNIITNHILNTSRSSYTFFNNLYFKTRQFLKSNPDLVVTKADKGNVTVILDKTQYLELCSSLIDNDGSYKPISSDPTPTLQRKCNALISSLAVSKQIDNNTKKKLTTYNGTIAKFYALPKIHKPILSVRPIVASIGTPTEYISAFVTDILTKAYDYENRYYVKDSFQMVEKFNGYKLPDNYVLVSLDVVSLFSNVYLRISLMVIEANWDRIGGCCSISFDNFINIVEFLFTNTYFSFNNKFYQQTFGTPMGAKISPIIAAYVMDYVLDTVIPVLSFNIPFIKKYVDDIILAVPSDKTDELLNTFNSFIPNIQFTIEKEDTNFSVPFLDIRMIRDANNIIKIDWYQKPTHSGRYLNYHSYHKHSTKVNLVKQMKSRVIKLSDPSFHNKNLQILTKLFISNSYPTTLINKILFNTVHNEDLTPSPATNNVDLDGLGNDRVSNTPTLNRYFSIPYIKDITPGLTRIFNNLESNNNNNDNHFKINVAFRSALTINNLFSKVKDKTEIGKLSNIVYKVPCSSCNKSYIGQTSQLLKFRITLHKSDSRLQPDRCALAKHVHTTGHSMDFENTLVLHQENNKFKREFIEMSYIFLNDSSINVKGDFKNLSDIYHLLLRSDTSHRSNLHDSNLTDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY21</accession>
    <name>A0ABM5KY21_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine protease K12H4.7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515091.1">
        <property type="nucleotide sequence ID" value="XM_050659134.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659134.1">
        <property type="protein sequence ID" value="XP_050515091.1"/>
        <property type="gene ID" value="LOC126890277"/>
    </dbReference>
    <dbReference type="GeneID" id="126890277"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60313" checksum="4B4B5C5EEDD81C45" modified="2025-10-08" version="1">MVEESLRAVGKQFGSLGHSKKIAQYMYDSRHRRWKCVRNNVNSNSAQSLTSRYFVNDEFAGGNRNLAFLQIGGENEASSSWVTGGSWITYARQYKAILFELEHRYYGNSHPTVDLSTENLVYLTSQQALGDLAFFIETMNRQYNLTPDVKWIVFGCSYPGNLAAWMRLKHPDLVHGAVSTSAPLLAKLDFPGKFLKLSHILCLEHVVGLSLTRVGVRLYTPTLYTTQATPSTLTSPVNQRSNFANSYASAASHSFPKYLEDVAASFRASSQTCINALQQSFDQVQVLLQTVAGQKNLNQLFHLCEDISLSVNNPLDMSNFFRKLIMVFADMIQYNKKLWGLQNITTVDWLCGILLDQSNNEPAINRLANAFNVNQNGNCFSYKYDIEISEFTNTAWGSLRSFGDRQWAYQTCTEFGYFQTSAQFPLSFFIQRCQDIFKSPYNKMFLDQAINRTNAFYGGLSIVNKVSNVVFVQGTLDPWRLLGITKSLNYKAPAILTKGAGHCANLLEPQYYDTPQLKASRVQIGAHIGTWINNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYD4</accession>
    <name>A0ABM5KYD4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Diabrotica</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="1031"/>
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            <begin position="1"/>
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            <begin position="181"/>
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        </location>
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            <end position="238"/>
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            <begin position="483"/>
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            <begin position="519"/>
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            <begin position="1"/>
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        </location>
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            <begin position="221"/>
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            <begin position="355"/>
            <end position="375"/>
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            <begin position="484"/>
            <end position="503"/>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ73</accession>
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        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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        <lineage>
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            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        </location>
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            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="277" mass="31557" checksum="AA464AEC45E566F8" modified="2025-10-08" version="1">MEYYLWLLIYACNICAAATISSGIKWVRVNVPQYRVPGETAMLQCEFDLGNETLYSVKWYKDHEEFYRFVPKERPQANWFEVEGVNVDMSRSDSKKVVIRPVSWKTSGLFRCEVSAEAPSFASAQSEAKMEVVALPTENPVITGVEQEYQIGDEINLNCTSGRSHPASILHWYINEQQISKQDALIPYPEEYHQHGLVSSVLGLKFRLGNHHFRGGSMRVKCVASMTPMLYQTDRESVVQTQTLPLREALLLVKSVSSRTEWSMAVLLFSIVHILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0Q7</accession>
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        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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        </lineage>
    </organism>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_050660064.1"/>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="327" mass="38262" checksum="1D449F28AA233732" modified="2025-10-08" version="1">MMNESTIDILNETEYESDQFASVPAIEGQFPKSLNGLGYYLLVITIIKLFVVLAVLIINIFLVIVILRFRRLHAIRSNIYILNMSIMNIIFYLCTPLFYIICHLVSAHEQQSVLILQTQSTLLILYLTFAVAMSVDWILTVSKPQLMKRFEHRCKYLIFGIYILFFMEWIVAFIYSEVEHIARANSFTIFYVIYAAILTALNVFKNRVEIRHESKNTEYALTVGNIVVYSYLPRFFFHLLLLIPLDFLDKILLFLEIIPDFIEIGHPIVVIYMLWRSNKYFKMAFSKSFKRSVQSYEDENLDLSENYQSNPYDFPLSSTSGEVQATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0T8</accession>
    <name>A0ABM5L0T8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516054.1">
        <property type="nucleotide sequence ID" value="XM_050660097.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660097.1">
        <property type="protein sequence ID" value="XP_050516054.1"/>
        <property type="gene ID" value="LOC126890928"/>
    </dbReference>
    <dbReference type="GeneID" id="126890928"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="53787" checksum="FAD0038FF5386DE2" modified="2025-10-08" version="1">MSESIDKLASYLTTSQNKILKSFFPNEIQFNLSTRKGVFPYEYLDSWEKLKDENLPPKNAFYSTLTKTHISDDDYNHACNIWTEFHNNTLKDFSEIYLTTDVLLLGDIVENFRETSLKTYGLDPLHYYTAPGLSFDACLKITGVEIELLDDIDKVMFIERGLRGGISQVSNRYGKANNKYMSKDYNEQDRDSYLIYWDFVNLYGTIMCFSLPYGGFEWIDPNVMPDITTVDKNSDIGYILECDIIYSKELFNIHKDLPLCPEHLIPPKSKSKVTKLLTTLFDKKHYIIHYRALQQAVTLGLKLDKIYRVLKFNQAPWVKKYVDLNTELRKKSKNEFESNNYKMMTNSFFGKTCENVRKYKDCKLLSKWEGRYGVRNYISKPNFHSLSIINENLVVVEMKRTQITFNKPLFIGFSILDLSKVWLYDFHYNYTKNKFGDNAKLLYCDTDSLIYHIFDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0V4</accession>
    <name>A0ABM5L0V4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516073.1">
        <property type="nucleotide sequence ID" value="XM_050660116.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660116.1">
        <property type="protein sequence ID" value="XP_050516073.1"/>
        <property type="gene ID" value="LOC114332455"/>
    </dbReference>
    <dbReference type="GeneID" id="114332455"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009318">
        <property type="entry name" value="Gustatory_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06151">
        <property type="entry name" value="Trehalose_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="150" mass="17703" checksum="08194F75A50B8FD6" modified="2025-10-08" version="1">MILNESTAGKAVKEASTESESVIIRTYELKNKYSFVFCLNTNFIIIAFFKLSMCWPKLLRHFCKTENSIRKYGYYINCHKRFIIILTVAVGTVMLEHSLAVANTYLNIEPSKYLEHNRTRLEQYFREEFPFIFDYVAYNVVLGFTIFTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L166</accession>
    <name>A0ABM5L166_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516180.1">
        <property type="nucleotide sequence ID" value="XM_050660223.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660223.1">
        <property type="protein sequence ID" value="XP_050516180.1"/>
        <property type="gene ID" value="LOC126891045"/>
    </dbReference>
    <dbReference type="GeneID" id="126891045"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19290" checksum="BAB1B491EE73EFFE" modified="2025-10-08" version="1">MSKNKKNKPLSEKELYELIEAGLSDVEEFCDEETDEILTFEDLQRDDGIIGNDNDTNSQVNDLEIEFSESVTSQSSASHVVNNDYTTSQDLKKLQDKNTLSSKISSDSSSDSSSDSESSSCLDSRSRSSEVSRNDPFSEDDSVKDPNFDPSLDISSSEHEEDKLQLPKSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L241</accession>
    <name>A0ABM5L241_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pao retrotransposon peptidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516509.1">
        <property type="nucleotide sequence ID" value="XM_050660552.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660552.1">
        <property type="protein sequence ID" value="XP_050516509.1"/>
        <property type="gene ID" value="LOC126891375"/>
    </dbReference>
    <dbReference type="GeneID" id="126891375"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955:SF77">
        <property type="entry name" value="ASPARTIC PUTATIVE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22955">
        <property type="entry name" value="RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26436" checksum="ED96E1D10A895B39" modified="2025-10-08" version="1">MPSLVARMFDPLGFLSPITLLLKIWIKKLWTLKVDWDSTVPKEIEIAWEKFQNEFHVLYKIQIPRHIAVTPNSSLSFVGFSDAISAGYAAIVYSRVVNCTGQVKVTLLYSQSKVSPMSKITLPRLELCGALLLSKLLSHAIETYFPRHNIDKIFALSDSMIVLNWIKSSEKNLKIFVQNRVVTIHKMVPSEYWFFVPGKENVVDCASRGLFPSSLVNHPTWFTGPNWLLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L251</accession>
    <name>A0ABM5L251_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516510.1">
        <property type="nucleotide sequence ID" value="XM_050660553.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660553.1">
        <property type="protein sequence ID" value="XP_050516510.1"/>
        <property type="gene ID" value="LOC126891376"/>
    </dbReference>
    <dbReference type="GeneID" id="126891376"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="331" mass="37386" checksum="6F1966DA1849DC90" modified="2025-10-08" version="1">MADLNKAGPSGVKRRKTVKVRNEKNLSVEELMQFLYNSDSDEDYEDSDVDNFEIENVSEDSSGSDTEDDVLQNELNNTVADNPDVQITDNEWTETTSGMKQIPFTKRSGLLVDSPGDSAYDWFRLLFDDELLNMIVLQTNSYAVEVLSTSKGCDRSRISLWKELTISELLIFIGLTFHTGTIQLPSIQDYWKKNRLFSTCFSSYMSRDRYLLIMRCLHFAENVKENEPVPVDRLYKVLNTCTELNRESREESNVSVVSDAPAATSQNPESEDLETETTPLSDISVHEPQQGPSNINRVSTVAIADLYTPTDKQNQTWSDNPNSSQTSIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L276</accession>
    <name>A0ABM5L276_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516544.1">
        <property type="nucleotide sequence ID" value="XM_050660587.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660587.1">
        <property type="protein sequence ID" value="XP_050516544.1"/>
        <property type="gene ID" value="LOC126891414"/>
    </dbReference>
    <dbReference type="GeneID" id="126891414"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="453"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="922" mass="105125" checksum="6DDE77ADB1FA672F" modified="2025-10-08" version="1">MSNQPLTHQQLVDAMNEILEGESEGEILYSSSDEEWQQPDQVDSSSDDDTELTVPQSESNVVEEPVSHSTSDIATEIKKELELLNISVNQLRITTAYPQKADDVFDEVYVEVDVAVVNHRADLWLRAANRMDLMENSIESLHKYLKLCELHFESKVISCEFKRNLRPGCSKFLDLNGSDVESSGHREPFSAYVSEDVPSSSEGGYTNTFVVGSSYLDGPKEKNLQEIDKDNIEQNSHKKKKRDMPRKCAPGRLSEDELRRLAEESDFSDSSMSESTFYDSDADPVYNENVTDGSSDSYSSEYESRRKKAKICKQTQNCKEFTAGSSSNQKEADTRRIGKLFKNAQIRFVLYFFFCFVEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVVSRNKITWSDVPNPDDLNKFELSFTSGINQEELAKLTDHKPIDFYLLFIDRQVQDLLVTETNKYAEQTIIAGIVNESITKHSLMSNWRPIDRKELLRFLALIIWMGLDRKPKLRNYWSNNLLYKNEVSKMCEISRSRFEILLHFFHISDNESCPPGNRLYKISPLVQILNEKFQKMCTPRESLCIDETMVPFRGRLSFLQYIPGKRHKYGVKLFKLCVADGYTYAVKVYGGKEMQPSEKSLASRVVMELMQPLLDTGRSLYTDNFYTSVDLAHDLNNRKTHLVGTLRSNRKHNPKAVVNAKLKRGDMKYLQSNTKVVIGKWKDKRDVLFLTTKDIPLMIDVQTKRGPVPKPSTIVDYNSAKSFIDVSDQKAAYNSPVRRSMKWYRKLAVELLTNTALVNSLVLYKSVTGKHLSITEFREQIVQSLLMPQTTSENSLTTSENSLTTLHTLDEKEKRGRCSACYKNFSNREGRASAMKNAKRVYTFCPACAVNTAYMCVKCFVNIHTCSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2N2</accession>
    <name>A0ABM5L2N2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN-DOC-like zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516690.1">
        <property type="nucleotide sequence ID" value="XM_050660733.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660733.1">
        <property type="protein sequence ID" value="XP_050516690.1"/>
        <property type="gene ID" value="LOC126891557"/>
    </dbReference>
    <dbReference type="GeneID" id="126891557"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="508" mass="58423" checksum="06BE8846223975AF" modified="2025-10-08" version="1">MEKKRKIDSECRKFKDQWNIQYFVIESSNKALCLICNESIAVLKEYNMKRHYETNHSQNYSKYTGIVRTEKFEALKCGLKSQQSLFTKVKTEQEAATRASFRVALEIAKRGKPFTDGEMIKECIIAVVEEMCPEKVNLLKTVSMSANTVARRVQNIAENISSQLFDKNGHVEWFSLALDESTDVSDTAQVLIYIRGVDKSYEVHEELLDMYSIHGTTTGIDIFKGVEMAINKKNLRWKNLKCITTDGGRNMSGKDKGVVALVSKAVENDGGSKPLVLHCIIHQQSLCGKCLDMSDVLKPVISTVNFIRSFGLNHRQFIAEIGETDLPYHTAVRWLSCGKVLQRFFELRAVIEIFLNEKHRPLTELQNNAWLWKLAFYVDLTTHVNELNLRLQGENHHLPDLYTNIKSFRMKLILFQSQLRSKCFSHFKTCEIFSHTTETEFPIDFAIETLSALKINFDTRFSDFDAIANQIKIFQNPFDADIETLAPELQMEMIDLQCSDIIKNKYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L556</accession>
    <name>A0ABM5L556_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517570.1">
        <property type="nucleotide sequence ID" value="XM_050661613.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661613.1">
        <property type="protein sequence ID" value="XP_050517570.1"/>
        <property type="gene ID" value="LOC126892154"/>
    </dbReference>
    <dbReference type="GeneID" id="126892154"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="3">
        <location>
            <begin position="226"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="350" mass="40289" checksum="F63D00322F843A27" modified="2025-10-08" version="1">MPWVVLRFPESETIEAVPAKWYDKANKLCKFPPVDDHTEKELSNFIIEEYDPLEEWPINEAVLESQTEFVLFNKAHIRASKACNSQNYKSDKETVLPQKRPPKPRKIASSSSEQDSDGSDLVFEHSFPKSKKEQHEKCTPSKSRTHPNIGLENKQEVKTVQETSKPTPTNANAQETAISYLIRIKRTLELQEQKLSEIDRKVDELSTIIRGQQKSTDITDDEVHKKLPLSTLEELGDVEKLLENATNLDNFVIYMRQVGGFDYKESVRRCLKKIFNDQLAVIYSFQGHKGKNPFNKTLICTAVIKSILKLHIDCTSKEVEVAISKWLTKAKERMKKNEEHTINFNLEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6D8</accession>
    <name>A0ABM5L6D8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517997.1">
        <property type="nucleotide sequence ID" value="XM_050662040.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662040.1">
        <property type="protein sequence ID" value="XP_050517997.1"/>
        <property type="gene ID" value="LOC126892497"/>
    </dbReference>
    <dbReference type="GeneID" id="126892497"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="295" mass="32993" checksum="A9AB97F5B3FA424A" modified="2025-10-08" version="1">MDLDCHEKCVIAAKRVICEESREESPVPRKKKRCELFDVVPSVISPAVPEVSGREKRASSEDSIIYVGCETLTPKTIERERLILKVKKNKVVVTPQTITVAAEVHAPPSTSSDYVPVIEDISEPEDGTPVLTYSKPSVEDEILNIADYKREEIEKPMTEVKVLEKKIISESQPSLNTVVADVLQITNSDEAHHIAFCDDFKGGLVAALERHRDRLKNRLDENTKDSDLLEEAVQNIFSYAKKMMEAFHLEKTRLIVDLNNTKTLLANAVKSDSRDLFSKNAAGDIRRCGMTDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L797</accession>
    <name>A0ABM5L797_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518306.1">
        <property type="nucleotide sequence ID" value="XM_050662349.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662349.1">
        <property type="protein sequence ID" value="XP_050518306.1"/>
        <property type="gene ID" value="LOC126892713"/>
    </dbReference>
    <dbReference type="GeneID" id="126892713"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13121" checksum="69076FA4C2E8DB60" modified="2025-10-08" version="1">MVLFEEYLQDSTNFNNAVSELVKVGGSKAYDFVSRVGKLIITNEQALKYSWLGQKGKQKFCDTRIANLIIGKAYSIFYIFYNVRTFFRGINSNKFSKNDKRSTISYSVMVKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8J3</accession>
    <name>A0ABM5L8J3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518757.1">
        <property type="nucleotide sequence ID" value="XM_050662800.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662800.1">
        <property type="protein sequence ID" value="XP_050518757.1"/>
        <property type="gene ID" value="LOC126892913"/>
    </dbReference>
    <dbReference type="GeneID" id="126892913"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="151" mass="18011" checksum="41FD353996A57999" modified="2025-10-08" version="1">MGRKLDENSQKLDETSKKAEENSQRVEEKLEENSQKTEENNKSLEQKLVENSQKVEQKLEENSQKMEDKLEENNRKAEENSQRLEKKLEENIKRIEEQMEQRINKSIGEVKMLYGEIMSKHENLETKLTVENQEIKTQIQQHKERINITPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZT5</accession>
    <name>A0A6P7EZT5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114325083</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325083</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128814.1">
        <property type="nucleotide sequence ID" value="XM_028273013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZT5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273013.2">
        <property type="protein sequence ID" value="XP_028128814.1"/>
        <property type="gene ID" value="LOC114325083"/>
    </dbReference>
    <dbReference type="GeneID" id="114325083"/>
    <dbReference type="KEGG" id="dvv:114325083"/>
    <dbReference type="InParanoid" id="A0A6P7EZT5"/>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028128814.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="48229" checksum="DDC89A159E029AB6" modified="2020-12-02" version="1">MDSVWQVAIPVEIVSEIFQYLSRPDRLACSVVCQKWHNALSRRYLWKKIVLHVDRDFLEPSTTLLVREYCKYIRTLEIGWNRPLVQNRWLPLKVHDLSKRVIHFICVLYENNIQLSCFKFFEWHDIYAFKKIIFHISRFLKTQSNLKKLIFHNINLPRTECIRVLESCLGSKFSVTSLEIHNNYYNFNTAFATLEFVVFLEQFWNLMELKLDYFILSRPRVMDVITENCNEKLTFLEIYVDEIDLHSIIIPEKQWKGLRKSCPDIKVSIKIKNICHYEQIKFIFLMKAIPLNYFTLISNNKLNHKVSRNFEATLLRLTRNYHDTLERINLDLKNNRENLDHVIFSMILTCPKLKKLYFDGILNDNMHLFYEICQYKKSAKGIIMKIFPNKYKSITNVVHMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F188</accession>
    <name>A0A6P7F188_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized aarF domain-containing protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325271</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129086.1">
        <property type="nucleotide sequence ID" value="XM_028273285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F188"/>
    <dbReference type="FunCoup" id="A0A6P7F188">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273285.2">
        <property type="protein sequence ID" value="XP_028129086.1"/>
        <property type="gene ID" value="LOC114325271"/>
    </dbReference>
    <dbReference type="GeneID" id="114325271"/>
    <dbReference type="KEGG" id="dvv:114325271"/>
    <dbReference type="CTD" id="57143"/>
    <dbReference type="InParanoid" id="A0A6P7F188"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129086.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58999" checksum="D5F959FB601D16A9" modified="2020-12-02" version="1">MKATNMLQGKLRPILKYSLITSIIGGTALSLKTNQYHLDSIGIVRLSRAAYTVLQIGVIYKRDLYGRKLDPSSQEYKETKSSCHKRSAEKLLDLCCTNKGVYIKVGQHLAALEYLLPNEYVQTMRVLHSHAPTNSIEDVYKVIKEDLKCEPSDIFESMDPEPLGTASLAQVHKAKLKDGSVVAIKVQHPYVQGNSKVDMKTMEYLVKLMSIVFPEFKIKWLVDESKKNIPKELDFAQEGKNAEKVAKLFEDLDWLKIPAIRWDLTTKRVLTMDFVEGGQVNDLQYIKDNGINPSEVSDKLGRLYSKMIFIHGFVHSDPHPGNILVKKSEKGHCDIVLLDHGLYADLKDDLKVAYANLWLSILNRDRKGMRSHASSLGIEGNAYGLFACMITGRSWDSIVRGIDKEQMSKKEANFLKQNFTGILPQISEVLQNVNPQLLLILKTNDLLRGIEHALKTGERMGSFRVMSECCVKSVYNMRYTKTEKTLDRLKISLAELWALLKISVYYTFLNLKNRSLGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5C7</accession>
    <name>A0A6P7F5C7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114326695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114326695</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130909.1">
        <property type="nucleotide sequence ID" value="XM_028275108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5C7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275108.2">
        <property type="protein sequence ID" value="XP_028130909.1"/>
        <property type="gene ID" value="LOC114326695"/>
    </dbReference>
    <dbReference type="GeneID" id="114326695"/>
    <dbReference type="KEGG" id="dvv:114326695"/>
    <dbReference type="InParanoid" id="A0A6P7F5C7"/>
    <dbReference type="OrthoDB" id="6130045at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028130909.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37998" checksum="A53A49AB0C745A38" modified="2020-12-02" version="1">MTTEGEKNEQLTPQTPVLSVACRILRSPSHESVTTDLSLFSVSSAASDVHGGRRLLNFHKCDGQFVRGHSPNPDNRNQSRPADIPEILWFEEETELIRSCAALSSAVGLQKSFSTSDISQLPSPEEGPTLPGLRNAVSELALNSLQRSGFILENARLDQTSRSCSTWVAVGDIASTSQLPSPHGGQSNSNTQQPTSTPPPPVFTAADFIRSVNKKVRQNYIRRRLLTTYKAIERLSQSEFNLDRLEVTPSTATASLGSESSPINSQAAPSRLTVPGSSPTPSKSPTTSNSTNAAMLRVAKQRAGKNLPLTIRDVERERGKPLSKYERNMMIFNWLHTLDDTAYVEGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5N9</accession>
    <name>A0A6P7F5N9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114325038</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128765.1">
        <property type="nucleotide sequence ID" value="XM_028272964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5N9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272964.2">
        <property type="protein sequence ID" value="XP_028128765.1"/>
        <property type="gene ID" value="LOC114325038"/>
    </dbReference>
    <dbReference type="GeneID" id="114325038"/>
    <dbReference type="KEGG" id="dvv:114325038"/>
    <dbReference type="InParanoid" id="A0A6P7F5N9"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028128765.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11675" checksum="03E682CAC7ED6077" modified="2020-12-02" version="1">MGIPAGNVESGRKLFQQRCAQCHTVEQGGKHKLGPNLHGIMGRKAGTAPSYTYSDANKSKGVTWTEDTLFEYLENPKKYIPGTKMVFAGLKKANDRADLISYLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAW5</accession>
    <name>A0A6P7FAW5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Essential MCU regulator, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Single-pass membrane protein with aspartate-rich tail 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114328127</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SMDT1/EMRE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132706.1">
        <property type="nucleotide sequence ID" value="XM_028276905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAW5"/>
    <dbReference type="FunCoup" id="A0A6P7FAW5">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276905.2">
        <property type="protein sequence ID" value="XP_028132706.1"/>
        <property type="gene ID" value="LOC114328127"/>
    </dbReference>
    <dbReference type="GeneID" id="114328127"/>
    <dbReference type="KEGG" id="dvv:114328127"/>
    <dbReference type="CTD" id="37071"/>
    <dbReference type="InParanoid" id="A0A6P7FAW5"/>
    <dbReference type="OrthoDB" id="10039145at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018782">
        <property type="entry name" value="MCU_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904:SF1">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10161">
        <property type="entry name" value="DDDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028132706.1"/>
        </source>
    </evidence>
    <sequence length="89" mass="9916" checksum="03BE2A1AEDE646C9" modified="2020-12-02" version="1">MLWRLGVLYRTIPKLTIPPSINSNVVRYAVTNKHGVVLQEPHRTSFGVFKIFVTVTSGLLIGAAISKNIANFLEENDLFVPSDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHE8</accession>
    <name>A0A6P7FHE8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor A, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114328082</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132635.1">
        <property type="nucleotide sequence ID" value="XM_028276834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHE8"/>
    <dbReference type="FunCoup" id="A0A6P7FHE8">
        <property type="interactions" value="2450"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276834.2">
        <property type="protein sequence ID" value="XP_028132635.1"/>
        <property type="gene ID" value="LOC114328082"/>
    </dbReference>
    <dbReference type="GeneID" id="114328082"/>
    <dbReference type="KEGG" id="dvv:114328082"/>
    <dbReference type="InParanoid" id="A0A6P7FHE8"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028132635.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="30676" checksum="0B01BCC04C8CEF25" modified="2020-12-02" version="1">MAGQGFLFKTFNVFNSRIISANRLNVANFQTPTRTIKTETKERLKSLNIPEKPKKPLTPYLQYVNQKRSTIVKENPNILPKDVLRKLSEEWKQVTEEEKEKLKEKYQKEAEIYDKDILKFNTALTAEQREILQIANNEKKEDRKKRKITKLLKETHKPKKPQGPYLLYLQEQSKIRNVPLNILIKTVKNDWAQVSDSQKEKYRAQYAKEHEKYEIELENWEKKMISEGHPELVRVKHRVPEERPSRILDLKGKKPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI29</accession>
    <name>A0A6P7FI29_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114330570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135759.1">
        <property type="nucleotide sequence ID" value="XM_028279958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI29"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279958.2">
        <property type="protein sequence ID" value="XP_028135759.1"/>
        <property type="gene ID" value="LOC114330570"/>
    </dbReference>
    <dbReference type="GeneID" id="114330570"/>
    <dbReference type="KEGG" id="dvv:114330570"/>
    <dbReference type="InParanoid" id="A0A6P7FI29"/>
    <dbReference type="OrthoDB" id="6728452at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027805351" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135759.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11379" checksum="CB23A5E4F9334408" modified="2020-12-02" version="1">MRSLILTTIVLFAVYQAVDADGLIAFHPNFCNDSPGKCTENLVCSDSEILVPKGSLCGYCDDCYRKLNEGEACRSRFFGGGPFRGKCVDGLECNAEGKCSKVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FL43</accession>
    <name>A0A6P7FL43_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional enhancer factor TEF-1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114328891</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133668.1">
        <property type="nucleotide sequence ID" value="XM_028277867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FL43"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277867.2">
        <property type="protein sequence ID" value="XP_028133668.1"/>
        <property type="gene ID" value="LOC114328891"/>
    </dbReference>
    <dbReference type="GeneID" id="114328891"/>
    <dbReference type="KEGG" id="dvv:114328891"/>
    <dbReference type="CTD" id="136038485"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="50"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028133668.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49879" checksum="89278350B1772FC7" modified="2020-12-02" version="1">MYLGSVLTASTISSPWTPVTGPQADSNGPGPDTKNLDVGDMSDDEKDMAAADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVDHVAKEKALQTMSSMSSAQIVSATTAMHSKSAGLNLGLTHNPVPYPGAQFWQPGLQPGTSQDVKPFAQAAYTAGKPATAVSAGEVGALQSAPPPVWEGRAIATHKLRLVEFSAFMESPNREEYQKHLFVHIGGPALSYSDPLLEAVDVRQIYDKFPEKKGGLKELYDKGPQNAFFLVKFWADLNSNIQDETGAFYGVTSSYESNDNMTITCSTKVCSFGKQVVEKVETEYARYENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVSNRDTQETLLCTAYVFEVSTSEHGAQHHIYRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLU9</accession>
    <name>A0A6P7FLU9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114329229 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114329229</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134075.1">
        <property type="nucleotide sequence ID" value="XM_028278274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLU9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278274.2">
        <property type="protein sequence ID" value="XP_028134075.1"/>
        <property type="gene ID" value="LOC114329229"/>
    </dbReference>
    <dbReference type="GeneID" id="114329229"/>
    <dbReference type="KEGG" id="dvv:114329229"/>
    <dbReference type="OrthoDB" id="6233064at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043403">
        <property type="entry name" value="Gurken/Spitz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12332">
        <property type="entry name" value="KEREN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12332:SF1">
        <property type="entry name" value="KEREN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028134075.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29670" checksum="6BD44EB0D3413CAF" modified="2020-12-02" version="1">MFLKTLQLAHVMWSSRGWGWRSPLPLVFRCLAQALATGFHRFLARFSGRRRWHLYHHKYPPPWAFLLLVIVSSLISIVDACSSRSTPKPRPPATTPRPNITFPTYPCPPAYATWYCLNDATCFTVRIGDSLLYNCECPESYMGPRCEYKDLDGSYLPKQKMLETASIAGGATIAVFSVVILCIVVYLHYKRRAKAISTSTDCIDSRTITVSTPTFGTRWRTNPQQSSTNLPFRIQDRGDMKQQGSKVELQQVTTLLPTSNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNC1</accession>
    <name>A0A6P7FNC1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC114332244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114332244</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137804.1">
        <property type="nucleotide sequence ID" value="XM_028282003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282003.2">
        <property type="protein sequence ID" value="XP_028137804.1"/>
        <property type="gene ID" value="LOC114332244"/>
    </dbReference>
    <dbReference type="GeneID" id="114332244"/>
    <dbReference type="KEGG" id="dvv:114332244"/>
    <dbReference type="InParanoid" id="A0A6P7FNC1"/>
    <dbReference type="OrthoDB" id="6331233at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027640344" evidence="9">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028137804.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17955" checksum="6EDD9B6B9E6FEF68" modified="2020-12-02" version="1">MNLKSYVILFSILVFCVNKSTAFLKCYACSTTEDDADTHCLDNPGSKDTDILECDKKYCYVVRQDYKDPRGKLQSITRTCLDKPTYSNKIIEDATHRIYFRACKSDLCNGGNGHTDESSGEEGAFGDKGTIYVPGTGSNNAGKVKVFLSVNVVLFVVLCFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPC1</accession>
    <name>A0A6P7FPC1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD, quinone]-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114332576</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138199.1">
        <property type="nucleotide sequence ID" value="XM_028282398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPC1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282398.2">
        <property type="protein sequence ID" value="XP_028138199.1"/>
        <property type="gene ID" value="LOC114332576"/>
    </dbReference>
    <dbReference type="GeneID" id="114332576"/>
    <dbReference type="KEGG" id="dvv:114332576"/>
    <dbReference type="InParanoid" id="A0A6P7FPC1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF215">
        <property type="entry name" value="FI02019P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028138199.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69491" checksum="78DB93CB3C8C362B" modified="2020-12-02" version="1">MDTLSAYIPDIVSLENIQGAVGYLFLASMLRLFSLKSNLGNEQHYPEDYGPKLRDGDEFDFIVIGAGSAGSVVANKLSENAGWRVLVLEAGGYPSFLSDIPAFLFSLQGTDEDWQYKTEPSETSCLAFKDGQCRWPRGKVLGGTSTINAMLYMRGDKRDYDHWAELGNVGWDWNSVLEHYKQLENMKYLHASEQYGRDGLLELTKYDSGHPITQAITEANELLGYPVLAEENPERPLGSIIGSMTISEGARENSAKAFLGRIKERVNLYSAIHSYVQKIVIDPETKSAKAVEVKIGEKIVTLKAKKEIILSAGAINSPQVLMLSGLGPKEHLQELGIPVIKNLPVGYNLEDHVIHIGFDVSLKVESLLIPNKLGTIYKYFRHNEGELAGISMTNLLNFINTKNDSAYPNICYHYFFCPPSDPYLLPEIAKVSGLTDEIFLSKKDAAYSRPFLSLYSTVLNPKSKGRILLRSKDPGEKPLIHAGYFTDQNNEDIEVMLESIRYAEKLIDTPPFKQYDAQLVKLNLPKCEKYEYRSDDYWKCSIRHLSSTIYHPVGTCKMAPKEDGSSVVDSRLRVHGVKNLRVADASIMPKIVSANTNAPSMMIGHKAAVMIMGEWGNKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G350</accession>
    <name>A0A6P7G350_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114337182</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028143389.1">
        <property type="nucleotide sequence ID" value="XM_028287588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G350"/>
    <dbReference type="FunCoup" id="A0A6P7G350">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287588.2">
        <property type="protein sequence ID" value="XP_028143389.1"/>
        <property type="gene ID" value="LOC114337182"/>
    </dbReference>
    <dbReference type="GeneID" id="114337182"/>
    <dbReference type="KEGG" id="dvv:114337182"/>
    <dbReference type="InParanoid" id="A0A6P7G350"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027611760" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="12">
        <location>
            <begin position="194"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028143389.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="58868" checksum="2909BFCCEF06BE50" modified="2020-12-02" version="1">MNMNYQMWHVVCVLFTTSVLQGCVLADYWSDREDLIENDRSYGLGATLKLTEKEQRVNNVLMKYKLSEYDAGLEDLDTFLAAQHYFKVKDKIQYSKVFDIIKRIPKGASLHSHDEALVSEDYLFSLTFRDNLYGCIDGDDFKLYFFQKNNISDSCNWKLLSDIRKSDVRFNRFLKTKLTIITDDPEKSYPDINKVWKTFQAIFKSINGLITYKPVFEDYFYMALKELYNDNIKYMELRGFLPTLYDLEGNIYSQEEVVGIYSDVLKRFQRDFPDFFGAKFIYAPSRHCDNSTMDTFVETFRKIKKLYPDFVVGFDLVGQEDMGQPLTAFVPQLIELKNLGAKFFFHAGETNWYGETDLNLFDAILLNSTRIGHGYSILKHPLLSKYVKEQQIALEICPISNQVLKLVTDLRNHPGNLLIANGFPVVIASDDPSFWGAKGLSDDWYMAFMGMTSRETDLRFLKQLAINSIVYSSLDSIQKNAALSLWHNDWNVFIENMLIRFRYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4Y5</accession>
    <name>A0A6P7G4Y5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RUN domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114337715</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144031.1">
        <property type="nucleotide sequence ID" value="XM_028288230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4Y5"/>
    <dbReference type="FunCoup" id="A0A6P7G4Y5">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663267.1">
        <property type="protein sequence ID" value="XP_050519224.1"/>
        <property type="gene ID" value="LOC126893262"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G4Y5"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="346"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028144031.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="61593" checksum="3E7D100C8D0770C7" modified="2020-12-02" version="1">MDGGPSDFPFEEQPTGKRWDPLGAPNDEEIDRDLKKFGDDCGLNDQEVLEKIRTLEEEQELLNSSLFALTTHFAQVQFRLRQVVNAPSEDKEELLKSLEEFAFRGIPDVGHVQEHIDEASLADAVRLRRSQQKELIDKLKSQLRELEQYAFENGEAGIPQDMVLERQKIILNELKTRMNLEIDEQHFYQMSQADVSKQINMAFDQLVSPLKVKEHLVSQLKTQIADLERFISYLQTDTKHSKCSCHSSFKTYKEPHRGESTINLIQRTATLLQMFAVLQLGCKSQPFTKNDMKHSMKVNHWGDLRARLEMAIARVKELAEQSEFRKEQEGDYSSDSESLSVLCNVQLTTAVRKYLATCIRDLMQHGAYMPQSTSLVPLIGCFPRRNSLSSNQIHAWEIILEYYRMKNGEKYNSTPARKLSQSFNLDIAGASPSSNKQNMLCCIGSIISTHTPYKRSNDSHFKAFICAALNANKLVPWLTLIFTCNHLIKTYYQPWSYLAKTGFQDSLRSLDTLSGIKFQLPVDLAIRQFQNIKDVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G540</accession>
    <name>A0A6P7G540_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114334249</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028140088.1">
        <property type="nucleotide sequence ID" value="XM_028284287.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510847.1">
        <property type="nucleotide sequence ID" value="XM_050654890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510856.1">
        <property type="nucleotide sequence ID" value="XM_050654899.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510863.1">
        <property type="nucleotide sequence ID" value="XM_050654906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G540"/>
    <dbReference type="FunCoup" id="A0A6P7G540">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654890.1">
        <property type="protein sequence ID" value="XP_050510847.1"/>
        <property type="gene ID" value="LOC114334249"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654899.1">
        <property type="protein sequence ID" value="XP_050510856.1"/>
        <property type="gene ID" value="LOC114334249"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654906.1">
        <property type="protein sequence ID" value="XP_050510863.1"/>
        <property type="gene ID" value="LOC114334249"/>
    </dbReference>
    <dbReference type="GeneID" id="114334249"/>
    <dbReference type="KEGG" id="dvv:114334249"/>
    <dbReference type="InParanoid" id="A0A6P7G540"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="275"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="462"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028140088.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="74845" checksum="D9EF71CF25E303A3" modified="2020-12-02" version="1">MDDCWDDNPDPYEQPANPAFQYNTNTQYNANGWNQDRPQQNFRRGNSREQNTNWRQRDGRERRPDRDGRDRKPDREGRERRSDENSESLTVESKYVGRIIGRQGSKIASLQEESGARINIDKNSFGEETEIKISGDAAAIQKAKELIMELTTERKSNYEQNNQPREEPKQEMDLDTFLKQCEEAEKAEWEKYPPTVKEFYKEHPQITKMSQKEVDEFRLNSNNTMVSRVFQTETSLPVPKPCTSFYFAFHQYPDILELIKEAGFTQPSPIQCQAWPVLLSGEDLIGIAQTGTGKTLAFLLPALIHIEGQITPRNERTGPAVLVMAPTRELALQIDNEVKKYKYRGITSVCVYGGGNRRSQIDVVKKGIDIVIATPGRLNDLHDAGHLNVKYVTYVVLDEADRMLDMGFEPQIRRVMYAVRPNRQTVMTSATWPNGVKRLALSYMKDPIQVSIGALDLTASHTVHQTIVILQEEEKRDYFYNFVRNMGEDDKIIVFCGKKAAVTDITSDLQVFGVNCDCLYGDKPQEDREQAYLDIKSGVNRLLIATDLASRGLDIDDVTHVVNYDIPKNIEEYVHRIGRTGRAGKYGESISYFTRRDWSHAAELIKILEEAQQFVPEELREFADGYAAWKERKDREGPARGGGFRGGRGGGGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G831</accession>
    <name>A0A6P7G831_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114335043 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335043 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114335043</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140997.1">
        <property type="nucleotide sequence ID" value="XM_028285196.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140998.1">
        <property type="nucleotide sequence ID" value="XM_028285197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G831"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285197.2">
        <property type="protein sequence ID" value="XP_028140998.1"/>
        <property type="gene ID" value="LOC114335043"/>
    </dbReference>
    <dbReference type="GeneID" id="114335043"/>
    <dbReference type="KEGG" id="dvv:114335043"/>
    <dbReference type="OrthoDB" id="6757181at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044651005" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140998.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15362" checksum="7445136BE7FCBB39" modified="2020-12-02" version="1">MKYLVVLACVVVAAVASNLPNLPEGERLKLAQVHRDCQADPKTHVDEDKLRKLPNFVEDKQVGVHMRCMVVKAGLMKQNGKLDVPSITEKFRLVIKDASKVNALVQQCAVDSETPEKTSILFTLCCVKNDIQYYHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9J0</accession>
    <name>A0A6P7G9J0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable splicing factor, arginine/serine-rich 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114339352</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145784.1">
        <property type="nucleotide sequence ID" value="XM_028289983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9J0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653658.1">
        <property type="protein sequence ID" value="XP_050509615.1"/>
        <property type="gene ID" value="LOC126886672"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G9J0"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12259">
        <property type="entry name" value="RRM_SRSF11_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028145784.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="68896" checksum="485023D11E0E633B" modified="2020-12-02" version="1">MAVGSTKVVQVTNIAPQATKDQMQILFGYLGKIEDIRLYPTIRDVSCPVQSRICYIKFVDSTTVGIAQHMTNTVFIDRALIVIPISSGEIPDEYYALEMTKNGTIVPGLTPTDPKLPPHVINTIHRTEQEEVIITSDPHLHVNGLPPYPPLPSSYDTAKIEETRRTVLMLNYQPLLTNDDIIDFFNSAGEVKYLRACKGDSDDNQHMLIEFSDQASIVNALKLNGQEYKGQIIIVEHATQPITKPQAKSNEAAQKEIEEAMSRFKEAQNMINASIEPVIGMLTKDKRSLRRSRSRSRSRRKRSRSRSRRRSRSRRRRSSSRSRRSRSRDRRKRSRSRGRRHSRSRDRRSRSRRSRSPRRSRSRSRRRSRHRSKDRSRGKSRDRDRKSRDRSRDRKRSNEREDKDKDKEREKKSKDIESPEKEKTPKEAKERKSDKEGSAEEKRKSRSRSKSKRRSRSRDRRRDRRRSRSRGSRRRTPSPRGPRRRSRSRSRDRDKRRDKKSDKRDKDRRVRDKRSRSRDKEKERKSRSRSRDSRSTRSHSKVPRNYDEEEKGFDTEKDKPKEIESENIEKGSPEKSDNMDISNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD33</accession>
    <name>A0A6P7GD33_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium/potassium/calcium exchanger Nckx30C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114340746</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147316.1">
        <property type="nucleotide sequence ID" value="XM_028291515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GD33"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659297.1">
        <property type="protein sequence ID" value="XP_050515254.1"/>
        <property type="gene ID" value="LOC126890401"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GD33"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000004">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027669985" evidence="9">
        <location>
            <begin position="28"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="95"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028147316.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35647" checksum="471A8CBB3B93CE00" modified="2020-12-02" version="1">MTLRVAPLCSVVILAFLLSLAHRPAHADQEQGEHFYYLEHDHYDAENLTTALVYTVSPVPTLHHNETTHEEKDPLFPKDLFTQEQRRNGAIILHIIGVVYMFVALAIVCDEFFVPALDVIIEKLDIQDDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGMCAIFSKTVLSLTWWPLFRDCFFYSASLITLIIFFRDSYIYWYEALVLFSFYIAYVSFMKWNQPMERLVKKLIYKNKVTRVRSTDQLMPTSASVSIIDSNKVSRVYCYQPLLLPLLSNALTAKLNLYKPSYFCTLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGJ4</accession>
    <name>A0A6P7GGJ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable ATP-dependent RNA helicase DDX28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114336855</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143045.1">
        <property type="nucleotide sequence ID" value="XM_028287244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGJ4"/>
    <dbReference type="FunCoup" id="A0A6P7GGJ4">
        <property type="interactions" value="1380"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287244.2">
        <property type="protein sequence ID" value="XP_028143045.1"/>
        <property type="gene ID" value="LOC114336855"/>
    </dbReference>
    <dbReference type="GeneID" id="114336855"/>
    <dbReference type="KEGG" id="dvv:114336855"/>
    <dbReference type="CTD" id="33254"/>
    <dbReference type="InParanoid" id="A0A6P7GGJ4"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="123"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="307"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028143045.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="54134" checksum="27E1E28D34D92AF6" modified="2020-12-02" version="1">MFSVTRRVLKNCFNKRFIQNLQSLEGTIEGTSKNHSPSLLISCKRKKLNYHAGVQYKKFDEVPLASKGWNHSKSKGDFFLINRLKNEKSQRYSFDELNIHPKIRDALKIDEIRELTEFQARSINEVRKGSHLLLAAETGCGKTLSYLIPIIQDLISNKSETANTPKAVVIVPNRELAYQVGEIARHLGEAVGLTVKTVVGGKTKSLMMNPVFEDIDILVATPGALGKLSTVGIYKLNEAKYAVFDEADTLIDDSFIERMEGLIKRLPQSQFILVSATLPKRLPPVLGPIEPSLRHVVSPNIHKPLLNINQKFLRLTKSMKPSHLLQIAKGNTKPMLIFCNKNETCNWVALFLRENGVDCSNINGDMNYAIRIDQWNKFASGETKILSATDVGSRGLNTIQVVHVLNYDFPLYAADYLHRIGRVGRLGSPEACKVTNFVVGPPEVLLVQQIELAIRRNEALENVDGNITNIVQRKIARSQRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GH21</accession>
    <name>A0A6P7GH21_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36" type="primary">LOC114342483</name>
    </gene>
    <organism evidence="36">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="36">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61996"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:19466"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
            <dbReference type="ChEBI" id="CHEBI:231528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:61997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028149091.1">
        <property type="nucleotide sequence ID" value="XM_028293290.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7GH21">
        <property type="interactions" value="1384"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293290.2">
        <property type="protein sequence ID" value="XP_028149091.1"/>
        <property type="gene ID" value="LOC114342483"/>
    </dbReference>
    <dbReference type="GeneID" id="114342483"/>
    <dbReference type="KEGG" id="dvv:114342483"/>
    <dbReference type="CTD" id="43856"/>
    <dbReference type="InParanoid" id="A0A6P7GH21"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05495">
        <property type="entry name" value="Bromo_cbp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20910">
        <property type="entry name" value="NCBD_CREBBP-p300_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15557">
        <property type="entry name" value="PHD_CBP_p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15802">
        <property type="entry name" value="RING_CBP-p300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02337">
        <property type="entry name" value="ZZ_CBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.20:FF:000001">
        <property type="entry name" value="E1A binding protein p300"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain_CS"/>
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        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
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        </source>
    </evidence>
    <sequence length="2375" mass="258879" checksum="E54B3AD20889A3CC" modified="2020-12-02" version="1">MADHLVDGPPNAKRQKLDPFQGPSDSSDVLSNMLDLENDLPDELMSSSPWGSLSDNMTSSKPPAQGPGPGSLQNGIDNTDSSLRQQMQLNHLLQQSNKGLAGNTLVLASGPLGNKSPNLQSPPNVSVAKGGVVEVNLSNLTSGISTNAGLQSMANNGNSTQVMSSVQGINNSGGNMIMTSSNMSTMGGMAGGGLVVSSTVNKPLTNANMFAPGHPQHPGNHNVNQGLPNGPMMSRVGMHLNQRGAPSIHISGPRLQGVGPPLCGTQGMSGNPQYAQYTNPNSAAQGVAVGEYGVVAPQQKMNLQNSCPRFGGTQTTAGTGIGPPGCGGEGGIVQTQPPAPSPAQPQSGAPTGTQPGPQQATQNPGGPSGTGGPPAPSTDPEKRKLIQQQLVLLLHAHKCQRRESQANGEVWSCTLPHCKTMKNVLNHMTTCNAGKSCSVAHCSSSRQIISHWKNCVRTDCPVCLPLKQADKNRNNPNAATNPPQNNQSPNPSATDMRRAYDALGIQCPTTASGPSPTGLLPNPSQPRPALRLPLNTGNALPNIGSSMQGVRVLAPPGPAAPNVSLPLSSDPSNSAQAQGISQTAASIQQSVNNVMFGLASGAEAANQGLVNQLPTGLQPGQVTASPVTGTKEWHQHVTPDLRNHLVHKLVQAIFPTPDPSALLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELEEKRLKRKEMQLQLQHSSQQQQQQQTQQPQIRPNIQGMVTRPGVPVNVLPCQQQQQPNQSQQGVRSGSPALGGPPIGGIGVLNTASNRLMFPVQQQNSQPPTQQQPNVVGLPGPSPTTSNPGLSPFGNPLSQGSTHNSSSNSQFPATSNGPVSLPQVSPAGQNSQTNQFNDMLKQNRIPPSPSSFVQQTQSMSQSNQQNVAQNSTSRIPTTSSDSVATPLATSAGPKSVSSSRGASPAPATPVQASPSAIAASMGKGMSSSERAALNAPRQSSFSSQFAAITAAAERDEDSRSPPAGGSKGKLEQMKMETDIKQEDSEITENHMENHGGKSIKNEIKMDIKQEIKSEPLEENIKIKEEPGLIKEESNMSESSDIKPSITDTANATATGSDSKHKIFKADELRHKLMPTLEKLFRQDPESIPFRQPVDPQTLGIPDYFDIVKRPMDLSTIRRKLDIGQYVDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQSMGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYFSYQNSSLKAYGLASDRYTFCQKCFNEIQGDTVTLGDDPTQAQTAIKKDQFKEMKNDHLEMEDFVNCTDCGRKLHQICVLHIEAIWPQGFTCDECNKLKGQKKRDNKFTAKRLPPTNLGTYIEHRVNIFLKKKEAGAGEVSIRVVSSSEKVVEVKPGMRGKFVESGELAGEFPYRAKALFAFEEIDGIDVCFFGMHVQEYGSECPPPNTRRVYIAYLDSVHFFKPRQFRTAVYHEILLGYMDYVKQLGYTTAHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQDWYKKMLDKGYIERIVLDYKDILKQAMEDNLKSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAIFSSMEECEVGPDGKKKGQKKAKKSTKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSVQSAASLKPIQDPDPFINCDLMDGRDAFLTLAREKHYEFSSLRRAKYSTLSMLYELHNQGQDKFVYTCNSCKAHVETRYHCTVCEDFDLCIQCYEKEGHPHKMEKLGLDIDDGSSPSDSKANPGEARKLSIQRCIHSLVHACQCRDANCRLPSCQKMKRVTNHTKLCKRKTNGGCPICKQLIALCCYHAKHCPENKCPVPFCSNIKHKLKQQQLQQRLQQAQLLRRRMAVMTRTAPAANPIPGGANVTMGGAGVQSVVPGAVSPANSMSTGLPNPQMGIPSPHQPGIGLKPQTPPANVLQVVKQVQEEAARQQAPHVGYGKVNPGQVPGQNMPPPQIRNMGHLGAGQSGGNLLPMEQWQQRYPSGVAPGIRQQGPPVMQPNQMGQTPMQTNQAGVRPGTAPISAPGSMMQKQALQQLMQTLRSPQSAEQQQQILSILKSNPQLMAAFIKQRQQAQQIQQAGGGNPSQQQQLQHILNQQPNANQQHQNRMQIQGGLINQAQAQGLSQGPGPSQPMTQQQQWYKHQQMLAMRQQQAAAQQQQQQPSFQQPGACPTYQQRLPGIRQPHMGYNNSFGDQQYPPMQGLKPTPPPVQSPQGVMGPPQGQGISVQQQQLMQSVRSPPPIRSPQPSPSSRTAPSPRNQTVASPRGPQQSPHDLAAASEMLLSQNHSNALHPHASPVATPNQDSNNEVPTMTPQDQLSKFVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIP2</accession>
    <name>A0A6P7GIP2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-MNLL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase MNLL subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114338673</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB1 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145078.1">
        <property type="nucleotide sequence ID" value="XM_028289277.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508785.1">
        <property type="nucleotide sequence ID" value="XM_050652828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIP2"/>
    <dbReference type="FunCoup" id="A0A6P7GIP2">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289277.2">
        <property type="protein sequence ID" value="XP_028145078.1"/>
        <property type="gene ID" value="LOC114338673"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652828.1">
        <property type="protein sequence ID" value="XP_050508785.1"/>
        <property type="gene ID" value="LOC114338673"/>
    </dbReference>
    <dbReference type="GeneID" id="114338673"/>
    <dbReference type="KEGG" id="dvv:114338673"/>
    <dbReference type="CTD" id="31697"/>
    <dbReference type="InParanoid" id="A0A6P7GIP2"/>
    <dbReference type="OrthoDB" id="9923602at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012575">
        <property type="entry name" value="NDUB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15222">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15222:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08040">
        <property type="entry name" value="NADH_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028145078.1"/>
        </source>
    </evidence>
    <sequence length="56" mass="6515" checksum="D16EA9D620A1A062" modified="2020-12-02" version="1">MFYPIIPKGIGWAVFPAFGFALGWYLDKLETERLSMFRDKSALYGRVLKEGEKPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLP8</accession>
    <name>A0A6P7GLP8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114340327</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146867.1">
        <property type="nucleotide sequence ID" value="XM_028291066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GLP8"/>
    <dbReference type="FunCoup" id="A0A6P7GLP8">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291066.1">
        <property type="protein sequence ID" value="XP_028146867.1"/>
        <property type="gene ID" value="LOC114340327"/>
    </dbReference>
    <dbReference type="GeneID" id="114340327"/>
    <dbReference type="KEGG" id="dvv:114340327"/>
    <dbReference type="CTD" id="51295"/>
    <dbReference type="InParanoid" id="A0A6P7GLP8"/>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="12">
        <location>
            <begin position="239"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028146867.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44857" checksum="519979968E6F3D74" modified="2020-12-02" version="1">MFLKKILRYGSVISRCKQISINNNCPRSFQLSANRYEEQKDKKSLVLKDTFENIQNKNKNSYLEMVKIFVSRDHIYRRGHVEFIYSALKNMEEFGVNKDLEVYKALLDILPKGKFIPQNMIQAEFMHYPKQQQCAIDLLEQMEDNGVMPDIEMESLLLNIYGKRGYPLRKYWRMMYWMPKFKNLSPWPVPDPLPKDTFDLAKYAIERISSVDVNSVVSVYQTVDIPDSIDDTWIVSAQSKIQRRLLSEHKIEKPIFVEGAFRIWIKGNPINYFVLRGDPKPVLLEDKDPDDVSDLKVSLFNIKPPTAKHVKVIPSVHEQEDGVIFSVCATGTSSKDSLLSWIRHLEKDGYPNLGKVPVVFKLKSVSREIANLETETEEENKKIEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GN44</accession>
    <name>A0A6P7GN44_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114340078</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114340078</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146608.1">
        <property type="nucleotide sequence ID" value="XM_028290807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GN44"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645394.1">
        <property type="protein sequence ID" value="XP_050501351.1"/>
        <property type="gene ID" value="LOC126881242"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GN44"/>
    <dbReference type="OrthoDB" id="7583985at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028146608.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12982" checksum="927A17E2E7343199" modified="2020-12-02" version="1">MKTWFQLVCSERKLKNFEMRRNVKVLVVLSAAWMFVVVFYLQNNRELKSLGIAYSHAVCIKYNLAAVLHRCRRNYNKVLRPNTSSQQRLRGAEVPPRPEDGNGDPSTDAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GT36</accession>
    <name>A0A6P7GT36_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC114342590</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114342590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149207.1">
        <property type="nucleotide sequence ID" value="XM_028293406.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028149208.1">
        <property type="nucleotide sequence ID" value="XM_028293407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GT36"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645155.1">
        <property type="protein sequence ID" value="XP_050501112.1"/>
        <property type="gene ID" value="LOC126881110"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645156.1">
        <property type="protein sequence ID" value="XP_050501113.1"/>
        <property type="gene ID" value="LOC126881110"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6761331at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028149207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028149208.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22387" checksum="A7FCE308D9FF52A0" modified="2020-12-02" version="1">MSTEVKTISARAITKLKMEETQPRLTRSSSLDKIKKFNTFICSQQYYVLPALLNWLKSSQTNLQASTESTIYFLRAFIFNAFFKFYLLFFRKQQFSVEQIKIVAKKVIAVVISNFFETFSKCFEPTFLLMAGVYFGCFIVCMQLLFTIYLMYLLFLPLGFLFLMGCMMSIQYLCYKTMIPARPLSGKGKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTE8</accession>
    <name>A0A6P7GTE8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114346197</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152779.1">
        <property type="nucleotide sequence ID" value="XM_028296978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTE8"/>
    <dbReference type="FunCoup" id="A0A6P7GTE8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654987.1">
        <property type="protein sequence ID" value="XP_050510944.1"/>
        <property type="gene ID" value="LOC126887446"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GTE8"/>
    <dbReference type="OrthoDB" id="6761337at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006533" evidence="8">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="175"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028152779.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="47071" checksum="1FEEE5AB2D272227" modified="2020-12-02" version="1">MSTEVKKTLLLLNVAVVATMMKNKKKRKPRKYWVKPWLNAELGNLRLPQEFLDARDLQSFKNFLRMNEYTFLKLLEKINPRIQKKDTNFRQCIPSRTKLIITLRYLSTGETFRSLMYNYRVSESAISEFIPIVCRAIYDELKRDYLKVPCTTEEWLNISKEFEETWNLPNILGAIDGKHVIIQAQQQEGSAFYNYKKQHSIVLLGLVDANYNFLYVNVGMNGRVSDGGVYRESDLYKAVEQNVLKFPNDKPLPLRNTPVPFVFVADAAFPLSTHIMKPYPFRNMTRQERIFNYRLSRVRRVVENTFGILANRFRVLLNVNLLVPEKVKIVTLACCALHNFLRHELKTKYTGVNPERDINKKYTLACGLSAQGGNRPKKLAIEIREEFKEYVNGVGSVSWQEDMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1D7</accession>
    <name>A0A6P7H1D7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 678-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114343269</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149875.1">
        <property type="nucleotide sequence ID" value="XM_028294074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1D7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644125.1">
        <property type="protein sequence ID" value="XP_050500082.1"/>
        <property type="gene ID" value="LOC126880319"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H1D7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002394">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028149875.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46677" checksum="7A4B3A9F09483CF4" modified="2020-12-02" version="1">MEVIKQEISEETHRVEIDNNGVDDAVLDSLKYKIKEESNSESTDYALECLALKEFPIKAEIEQDGNEVTCFEEKQNTTEHVGFTLNENQMKSIETFFEHSSYKEPCMSLHTEGKTVNETVEVQTTHGSYNCEICLKQFSTPSNLKTHLVVHTKEKLHKCEICFKEFSQAGSLKTHLRVHSGEKPYKCEICFKQFAAKSNLKLHFRVHSGEKPYQCEICFKHFSQRSGLKDHLRLHNGEMPYKCEVCFKQFARNDSLKTHAYVHTGETPYKCEICFKQFSKASTLKTHLKLHTGEKPHKCKICSKQFSQAGALKVHLRVHTGEKPYKCEICFKQFARTDFVKSHLRTHTREKPHKSGEKPIYNAVDDGPVDICQIIIKEEPHEEIEQEEHKLSSFKEKETNPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAS5</accession>
    <name>A0ABM5IAS5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128759.2">
        <property type="nucleotide sequence ID" value="XM_028272958.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272958.2">
        <property type="protein sequence ID" value="XP_028128759.2"/>
        <property type="gene ID" value="LOC114325035"/>
    </dbReference>
    <dbReference type="GeneID" id="114325035"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128759.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="748" mass="85747" checksum="C3582061F0EDA2CB" modified="2025-10-08" version="1">MENNKIKKVHKNRPYAYSPGTPIINDSTSFSNSLSSSKSSSLQNVQALPTRILRIEGTSNYFMILPKNSPAAVPLQIQMVTTKTTPRILRKIPSKNQLLVKTKTSSPALKVIPKVGMPSNTVASRSNPNAAVPSQTKMVTTKTIPRILRKIPSKNQLFVKTRTSSPALKVIPKVGMLSNTVASRSNPNADVPSQTKMVTTKATPRILRKIPSKNQLFEKTRTSSPALKVIPKVGMPSNTVASRSNPNAAVPSQIKMVKTKTTPRILRKISSKNQLLVKTKISSPILHQLLTKTKISSPALKVIPKVRMPSNTVACRSQPPLKVVLSKNIKDRPTTLSKAHPKTQVVTKSECDWPTYINPFDYTSYVKNTLLYICRQEILESERNLMQEKESVFAWPCKICRKEFFEKEQLMEHYEMHKNTRDHLDDIDEINLANNISSKELTCPICSRSYAHIDSYKRHVVLKHKPKKHYCDKCKHAFTDDFDLSVHNTTHNQDPEWYECAKCKKFRTNTTRILYEHISNKHVKEEMYCNECDKTFLSKTWFEGHKIFHIDISKRGTYKCGQCESEFTSNYSLMEHMQGSHTKYKCDQCDVTFPYKQNLYEHNRRLHLKERPFLCKECGKTFRNLLWFRYHEKAHKTGKCVCHVCGNICAKQGFKIHMRIHTGEKPYKCNFCDKAFSCKSRYTAHARIHTGVKPYACSECEKSFSNKYGLVIHMRGHTGERPYSCSVCKKGFSQSSSLKKHIMRTHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IBE3</accession>
    <name>A0ABM5IBE3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129161.2">
        <property type="nucleotide sequence ID" value="XM_028273360.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273360.2">
        <property type="protein sequence ID" value="XP_028129161.2"/>
        <property type="gene ID" value="LOC114325316"/>
    </dbReference>
    <dbReference type="GeneID" id="114325316"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="89"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129161.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="285" mass="33201" checksum="874BD363A9E48083" modified="2025-10-08" version="1">MATAIDLSDNQEAKKFAEGELNETDETRVNSLEELKRWLQEEPQLHARLEDQYLLAFLRGSKFNMEKTKKKVKNYYKMRRDVPEWFSNRDPELNQMQELIKLGCFVPLKKKQDNRLVVIIRTAAHNPSIHTQDDVFKAGTMMMDVAAMENVISSHLYGVTAILDMTGQSFAHVRQLTPSTIIGKAVNCWQNYHIRPKHLEFINAPTAVHVVISIFKSFMNSKLRERVRTHLPGQLKDLYTVVDPKILPPEYGGEGETMQELIDYWNDKYISYKSWFLDDEQYKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICC4</accession>
    <name>A0ABM5ICC4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Intraflagellar transport protein 88 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129725.2">
        <property type="nucleotide sequence ID" value="XM_028273924.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273924.2">
        <property type="protein sequence ID" value="XP_028129725.2"/>
        <property type="gene ID" value="LOC114325797"/>
    </dbReference>
    <dbReference type="GeneID" id="114325797"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="631"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129725.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="94562" checksum="440AD91DB46DFC81" modified="2025-10-08" version="1">MATALVETPEFRPESSVDVSILKDDSNKIRIPDMSRLSTPKPVMHLASATEFHRQPSAVPKTPYKPGTGYRSGTGFKSNVFGKPGTGFKPGTAGYRPGTGIDTVNRPMTAVRGAGYTSHGKPFDPLNQAASVPTPPLELQKDDSPEERIRQQEYKIMQLVEQACISQSEGDFRQALTKAKEASNKERNLIRLQEQSGLGDHHNIDLTYAVLFTLANQYAANELYTEAINTYQMITKNRMFANAYRLKVNMGNIYFKQGQYQLAVKMFRMALDQVPSTQKHLRIRIMHNIAMVFIRMGQWEEAIGSLEYIMSEQACHRAGLHLVVCSRALEDKERMRSSFSLLLSVPLNIEDEDKYNLEQDSPEDALIALAIQDDDLHRYETQKRREAEYCILTAAKLIAPFIEETFGKGYDWCVSAIKISEYARLALDLEINKAVMFLKQKQLPEAIDTLKAFEKDSVIAINASVNLSFIYYLQGEYDAALRYAEVVEKQNAKSAEGFVNYGACLMAKDNLGEAITCFQKALACDPTFFEAIFNLGLCLKRQGHYIEALSCFQRFSGSLALLPAVVYQVANLLELIGDNEAAADTYQQLLGLVPTDAKALQKLGELYDHEGDKQQAHHYHTDSYRYYPANLSVIDWLGTYYIEMQVVEKALTYFEKAALMQPQEPKWNMMVAGCHRRSGNMHKALTLYQEIHRQFPENSECLRFLVRLCGDLGMREAQDYLMELKKLEKSKEVRERVNSSRPGSRRTNSGLSSRAGSGFSPVPENGPLKSPPHSGNRNLRSSRLIQAHNSGGSADSGFAQPAIDASYSDPLGPQPLRPRTGAGKPLDFDDFSNEELGDDLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE05</accession>
    <name>A0ABM5IE05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCR4-NOT transcription complex subunit 6-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130737.2">
        <property type="nucleotide sequence ID" value="XM_028274936.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274936.2">
        <property type="protein sequence ID" value="XP_028130737.2"/>
        <property type="gene ID" value="LOC114326542"/>
    </dbReference>
    <dbReference type="GeneID" id="114326542"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130737.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19750" checksum="C88C8CEC4C311199" modified="2025-10-08" version="1">MPRKDKFENNGGSTNRRTHTYMSAEDQASGKKSYWTELEITGTIRNLSSNLFQLTHLTALYIKNNQLLRLPPDICSLVNLRHLDVSNNKLRSLPAELGELIHLRELNLSNNSLRILPYELGKLFNLLSLNLGGNPLNKDILTIYNEPNGTVKLLTFMLDNLQGKHLFNYSGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGK9</accession>
    <name>A0ABM5IGK9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small ribosomal subunit protein mS39</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132318.2">
        <property type="nucleotide sequence ID" value="XM_028276517.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276517.2">
        <property type="protein sequence ID" value="XP_028132318.2"/>
        <property type="gene ID" value="LOC114327808"/>
    </dbReference>
    <dbReference type="GeneID" id="114327808"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037387">
        <property type="entry name" value="PTCD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055063">
        <property type="entry name" value="Rib_mS39_PPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16276:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22330">
        <property type="entry name" value="Rib_mS39_PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="repeat" description="PPR" evidence="12">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132318.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="653" mass="74586" checksum="D467DCDB907037E3" modified="2025-10-08" version="1">MNLSAICLRRTPVLNSSLKTWVRGFSSSNTEERIEIPNRIPRGPTDILRALESTISRDPTASHYKYHDDPYLIPKSNVSKRTFAMAQEAGRKAAHWIRKEHADLFNHLEADPIVPSFLPKLVYTEDSKVTEDDLKKVIQDIQILDAQLVYQLLKKQGVVISPETQQSLLELVCYFNSDDTLPEEFIEERWFKQSSNQKERQRKTWKDGSFAEELFQSLENPTAESYSAMIQGMSKYFQVERAWKLFEEAQQKGLVLSPNTYNSLLKVANFLKESFEMRWTFIVNLLADMNRAGVKPNLGTMNAILHSLSTMGRGKSVREYALQVLAEFRGLGVEPSLGSWYYVLITYCKERGPISTILHDILPHIENKDHKIKDQSDTYFFVTAMDICRNHLKDVELAKRVDKLLHVGSNYDLIGDSYKESIYYRHYFVLLATSIPLEEFMTTTYEILVPNIYVPEPGVMAEVLKQVELNGAIEYIPKLWSDMTVFDHVEQEKLIHSITGIMVSNIPEKNSSLHENFANIAWDIHTRVENQNTNKVNKLSLTGNLLGRILLLILRNDDFEKACIIMDKLDKDHQTIAGVPDIEALECFVDSCIERKAPSRAIACIQYCADSGFQEAGIFAAKLNEKLTLDESHLNSLSRIVGDVKLAKVSDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHQ8</accession>
    <name>A0ABM5IHQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133096.2">
        <property type="nucleotide sequence ID" value="XM_028277295.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133097.2">
        <property type="nucleotide sequence ID" value="XM_028277296.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511953.1">
        <property type="nucleotide sequence ID" value="XM_050655996.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511954.1">
        <property type="nucleotide sequence ID" value="XM_050655997.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277295.2">
        <property type="protein sequence ID" value="XP_028133096.2"/>
        <property type="gene ID" value="LOC114328443"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277296.2">
        <property type="protein sequence ID" value="XP_028133097.2"/>
        <property type="gene ID" value="LOC114328443"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655996.1">
        <property type="protein sequence ID" value="XP_050511953.1"/>
        <property type="gene ID" value="LOC114328443"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655997.1">
        <property type="protein sequence ID" value="XP_050511954.1"/>
        <property type="gene ID" value="LOC114328443"/>
    </dbReference>
    <dbReference type="GeneID" id="114328443"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026698">
        <property type="entry name" value="UPF_C3orf38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21084">
        <property type="entry name" value="DENSE INCISORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21084:SF1">
        <property type="entry name" value="DENSE INCISORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15008">
        <property type="entry name" value="DUF4518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="130"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133097.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="284" mass="31813" checksum="0FCD9700FF85B203" modified="2025-10-08" version="1">MANNSETGIIDLLSKLDEDNLLSLGRTVTQGLLKINSKDDAIKAILKHSPDTLSILRRKSVTREVLFSYLDEKDIVMKAPITKNELIDRIMEFWNIKRADVITTVSCRNNEETISETKPLREDSNSISALAEQFAGWFYSLMNDEGVGPENFYPDAKMKINLHSNNDCDTIVVEDDPDGLAQQLLRIKLQHGIFFNPNVSKEGTQGRMDPHGLVVVLVCGTLHVQKTCVGVFEQVFSLARDPFCDNNWKIKNSELNLRSKSAVMGQPRLCDSELTSNLLSLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IP26</accession>
    <name>A0ABM5IP26_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137787.2">
        <property type="nucleotide sequence ID" value="XM_028281986.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281986.2">
        <property type="protein sequence ID" value="XP_028137787.2"/>
        <property type="gene ID" value="LOC114332225"/>
    </dbReference>
    <dbReference type="GeneID" id="114332225"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137787.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="403" mass="44589" checksum="CD97E8EB10E98235" modified="2025-10-08" version="1">MKTVIKTYDWKNKGIILSAYMWGLAIPQLFAGWLSSRYNIKRILISMMITASIIGFLIPVAAANFGSTGVIICRLIQGMALGTTGPCQFSLYGKWIPPNERCTLMGVVFSGDLLGIIVSMFLSGVLAASRFGWPLVIYIYSTIGLLWSVLFAFVASNSPAEHSTITKEERYYIQWSLSQNHKRKYITPWRKILTSACVWSSIVSKAGSFFGFILILTQISNYMKNVLKFDIKENGIYSALPYICTFVAVSLFGYISDKITSRNILSVTTTRKLFVTIGTIFPCLTLLLITLSKPEEKVKIIIAFALTVSLDMAGNIQGTGINSVDLSPNHAGFIEGLSNQVSQILSSLSPLLVDLFVSNEENNAQWNIVLYISLGIRIVSATIFLIFGSGQVQPWNEEILADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPA3</accession>
    <name>A0ABM5IPA3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137945.2">
        <property type="nucleotide sequence ID" value="XM_028282144.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282144.2">
        <property type="protein sequence ID" value="XP_028137945.2"/>
        <property type="gene ID" value="LOC114332358"/>
    </dbReference>
    <dbReference type="GeneID" id="114332358"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046883614" evidence="3">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137945.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="354" mass="41384" checksum="564C9FBCD259A985" modified="2025-10-08" version="1">MALVLLFLVLFVHISSENLVDITFRNVTFNGYFVFTPRFKPTILLGNNLKDFIPNTNFDNIEFIDQKIPIFYKDAIADIDRLTELYVENCNVEEIRPGTFRNVSNLSKLSFRYNKLRLIENGVFNHLNLTTLDLSFNQISVIYPDAFNHMHELFHINLAYNLIPTWNPKWFKDTPNLYMLYFKANLIEELPAHSFKNLKRSKLSVLELIFSNNNISKIDPQAFSEVRQINLLSLSNNKLESFDKDLLKNVVVWDLRLNNNSISCFDGDLDKLFKAPYNYIEYNPFTCPCLHRLKHWSNKRGKELGIADSKCTGGDDEEEEDKVIEMEEVFEVEKDVYAIQKITLVLPKNSKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPU9</accession>
    <name>A0ABM5IPU9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138404.2">
        <property type="nucleotide sequence ID" value="XM_028282603.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282603.2">
        <property type="protein sequence ID" value="XP_028138404.2"/>
        <property type="gene ID" value="LOC114332825"/>
    </dbReference>
    <dbReference type="GeneID" id="114332825"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="54"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="386" mass="44094" checksum="1FBC95A138C8F5D1" modified="2025-10-08" version="1">MFLDKSNRTEKLIKTVSSLGYPIEAHQIGTEDGYILTAFRIPHGRNATMSSNLPIILNHGMLGSAENYIWMGPQRSLAYILADNGYDVWLMNCRGTSHSKKHKKLNPEQKKFWDFSFHEIGAYDIPAVIDHILNATDQSNLFYVGHSQGCTTIFVMGSERPEYNEKIKLAVALAPGAIYKNFKQPWIELLLKLVPLDQLELLADSLKLYQIPPPYFSENDIAELLTMLCVTNTNKFMKKLCNLSFEMTADTDMENIDQEDVASILSILIDSISVKQALHYGQLIVSGNFQNYDYGPKINKQKYNTSSPPLYDLKNIKYPTALFFGKTDQLVSPEDTRLLAKQLPNVVYYSPVPLTHFSHLDFIINKHNEHFVYTPILKLLERFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRS7</accession>
    <name>A0ABM5IRS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosylphosphatidylinositol anchor attachment 1 protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139920.2">
        <property type="nucleotide sequence ID" value="XM_028284119.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284119.2">
        <property type="protein sequence ID" value="XP_028139920.2"/>
        <property type="gene ID" value="LOC114334097"/>
    </dbReference>
    <dbReference type="GeneID" id="114334097"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139920.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71362" checksum="303410910A897225" modified="2025-10-08" version="1">MGLLTDPTTGQGKYVKWLLKYYSKLCFLLYISGVIWFCTLAYPTMNASTYFSENALLPGLVKSQFHEDREALRYNEELQDEMKKYEDSIPYPWIIAKFKQIGLDAYIHNFTLTSPFNRNEKFSGKNIYGILRAPRGASTEALVLSTPYRPSTSVHPPTGPSIAIMLAFAKYANREKYWAKDIIFLITEHEQLGIQAWLEAYYGVSCGSEEVLDHGDLRGRGGAIQAAINLELHSEKIGQMDIKIEGLNGQLPNLDLFNLASKMCAKEGVYQTFKNKGPRYSRDPVKEWWNYFKNLLSMMATQASGIPNGNHGLFHRFGIQALTLEGFERSRTKSNNKIMMVGIGRVIEGIFRSLNNLLERFHQSFFFYLLPSSERYISISLYIPSVCLMAGTMFIKACARWFNLQKSPEEEKKANPKSVVRVDRIIIIFLMTHFFGILISNLPQYVPLLTGYDKNTTIFYSLLGSSGLLLLLPLFIGLRKCRESMELLNVLAMLELGTALICISMNNFSLGLFCATILIPIALLINPSACRLCSIVQKLLWLLVHPITILTAVVAVNSYLMFPEEGAKELSNRAWDATQKSILYGIVDSMIYGNWLYTVVTNIFLPNWLCFWIVSFSKGSSDTNKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IY13</accession>
    <name>A0ABM5IY13_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148421.2">
        <property type="nucleotide sequence ID" value="XM_028292620.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292620.2">
        <property type="protein sequence ID" value="XP_028148421.2"/>
        <property type="gene ID" value="LOC114341807"/>
    </dbReference>
    <dbReference type="GeneID" id="114341807"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148421.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="290" mass="33113" checksum="4A6592AA1EA6E9B7" modified="2025-10-08" version="1">MDYIDNDMDPAKRLNKTGKDRLKAKVTTIAMNLANLAGQNKILREEIERLRKKNKSNETQRVSYARVAAQPAMATKTENERKIEMRKEENTLFITSDKATTGRKVQEELTKVLNPRAAKIPINRMKTTGKALIIEAASKEDIEKIKNNDIIRKSFKCELPKKRKPMVYDVSSSVKGEDIIEDLRVQTFEHMSNEEFEDSFKIRFKTGPRGKSTVHYVAEVSPELRKIIIKNKIYIGFNAINARDYIVVPKCLKCQDLGRVAKHCTKETACSHCGGAHEKKECDRTGQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYU2</accession>
    <name>A0ABM5IYU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein ush</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028150168.2">
        <property type="nucleotide sequence ID" value="XM_028294367.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294367.2">
        <property type="protein sequence ID" value="XP_028150168.2"/>
        <property type="gene ID" value="LOC114343226"/>
    </dbReference>
    <dbReference type="GeneID" id="114343226"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059121">
        <property type="entry name" value="CCHC_ZFPM2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039746">
        <property type="entry name" value="FOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034731">
        <property type="entry name" value="Znf_CCHC_FOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12958">
        <property type="entry name" value="FRIEND OF GATA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12958:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN USH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25445">
        <property type="entry name" value="CCHC_ZFPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51810">
        <property type="entry name" value="ZF_CCHC_FOG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="891"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="933"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150168.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="104992" checksum="6BDC015FA3DE5757" modified="2025-10-08" version="1">MAMVNLLAAALNSCNELQLNHSLRTIRVDTSKFREVEDWNSDPADNAVSTNPPSKSPPRKTATPEEPAEEITQISVKNETEEKTPRIRLKANLATDPALQSQPITLTNPKVESEVSQFSSGYLTALRPALQTALVSRGFFLPNIIPGAEPQSESVETRQQTVPIFQCSPCGIRFSSISTLEAHQTYYCSHRVNKAATDDDSKSVTDPNGNQSDADVSEPPLKNVRTGKQYTCTHCSYSADKKVSLNRHMRMHTVSPSPSPLNIVTTPNGESSTNSTDRYCAECDIRFSSQKTYRAHKLHYCNSRHTIKPQVVTTKASSSTSGSSPTSPIDSRPCRSPSSPSSQSASQQPFLALPTNPIIIVPYSLFRSASVFPALSVASGLPNPDTPCFLLPNGTLQPMTSALLNQYQQQQSEGSRNDSKSKEPSVVRETSSAPLDLSVRKSPDNNDLIIDFTEDRGRHTPNKSLTPDKSKSVHSSQNSPPTTPVSHCESSPSPKIKDEASRSSSPKRLRSVLKPTQEKSRTSPEVNNFQQFEGNPSLHPLLMRGALPLLPPEVQMRLEPPLPAVMPQVLVKQGVSKCKDCNIVFCKLENYVVHKKHYCSARSQDENLSKFSGSPPVSPNSIETTSPAAQYQQLICLACGIKFTSLDNLNAHQAYYCLKRGDTEVRKCGKCKGIAEPGHQCIPHAATLTGWKCPCCDVVSPTASAAQRHMESHTGVKAYRCTICRYKGNTLRGMRTHIRMHFDKRSSDLQEEKYISYILEDESSNTVEVNVTTAEPSDEKVGSPGNEPSLPDSLHYCLQCSYNSTYKANVVRHMKLVHDINITEEPPVNGLSDKNKSMPALEDDEEEIVVKKEAMEPEVIIAQGEEPIIKEEVGIKLPKSKTPDEEILQEAAKSGARYCKSCDIYFNYYSTFVAHKKFYCSSHAGEISNAASNNNITNNNNNNSATRAAAEASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZ69</accession>
    <name>A0ABM5IZ69_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151303.2">
        <property type="nucleotide sequence ID" value="XM_028295502.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295502.2">
        <property type="protein sequence ID" value="XP_028151303.2"/>
        <property type="gene ID" value="LOC114344673"/>
    </dbReference>
    <dbReference type="GeneID" id="114344673"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151303.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="636" mass="71253" checksum="735E3564E49F55EA" modified="2025-10-08" version="1">MKRSQQVTVTKTTTTYEEYEYETTFSVSKLSKLENFVLPPRTTILAVSQSGGDKEEDKKYVVTNHGKADLFVEVIHLNNQDDAPQWFVVQPDQTTEIDIEDNLEQSVLKVSNNSYEQEVSFSAKGGHVIDDLENNMEELLDSDETETEMTVLENFSLSPRTAVTVLSQNVEGSNEHPGKYTVTNLGKAAFDIELKRTSPVQTLELHRKTVQPNTSESFELTAQFQSTVLEVINTSQTEDAVFRAEGGDVIEDLEDLVRNIDEKAETALPLIPTSLDRFNLVSRSSVPALMYDPNDVTLSNSQKFTVTNNGKSDIEVEVTYTDSDDRANDQYKVVKPNETVEIEHKKDAGVALLHILNRDYTEVAIITAKGGRVVRDIERKIKQLISDEKSVMLVNNYHLAPASSVVVMHQVGRYSRRPMYPAGHRKLQHVVVRRLKHHPGLTSGRLAGKPAVSRPCKQSGSPAGSGRRPFRRPACRPMIRPAHLSGQGGQHPAQQEHHQAQQQQRPSQQQHHQGPQAGQCRPARRPRIVMRPAALRKPISHDKYTVVNHGTHALTAQIVHVKGGNQEVVRSQVVQPNETQELLLQGVNGSSLKIINENETDYAIFSAEGGEVIDGFRYMVRPLRRRPGARKMFYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZZ2</accession>
    <name>A0ABM5IZZ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154603.2">
        <property type="nucleotide sequence ID" value="XM_028298802.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298802.2">
        <property type="protein sequence ID" value="XP_028154603.2"/>
        <property type="gene ID" value="LOC114348183"/>
    </dbReference>
    <dbReference type="GeneID" id="114348183"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF55">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="137"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154603.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="399" mass="46126" checksum="0B7A42C8A0F992D8" modified="2025-10-08" version="1">MSSEDDLDDIKNLNDILKSFVDISKLTKTKITRLTAPGENYGSLMLKLDVTLKSDENSESDLHLVAKKIPPSELFRENFNIQVTFQNEVAMYQTVVPILQSFQRDYGVKNVFNCVPRFYGARINLDGGKQVDTDAVLILENLFANGYTNINRLQGFDLESIKLVLKDLAEFHAVPLALKLKRPEVFERDIKKYCNDFIFNKEFHTIFWKPTKSILLEKKELAPIVDKIKLICQADKPAVREPFATLTHADLWCNNSMQKFGPDGSALENKLIDWQFLSYGSPASEFLFLVLTSTETNILVNHFDELMQFYHTHFVKTLEDLQCDTIPFSLSKFIEEIKNECVFEIGHVIQFILFIVTAKKRDEELKLPEESDRLVETVSQQGKEKVWFILEDFEKRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM57</accession>
    <name>A0ABM5JM57_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499022.1">
        <property type="nucleotide sequence ID" value="XM_050643065.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643065.1">
        <property type="protein sequence ID" value="XP_050499022.1"/>
        <property type="gene ID" value="LOC126879795"/>
    </dbReference>
    <dbReference type="GeneID" id="126879795"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="765" mass="88372" checksum="BE08C74C3E3E0651" modified="2025-10-08" version="1">MSTLRNNIYLVGVMKNQICGSKLPCKRDVLSVLFYNMRVVNLNLNDSSALVIDEVVVFWKKARIPVQNRSNCILKLKSLYDNVRNLEKSKNRDTERQREKENDFKEALDNLFDIATLNALNEIKIAEDREFLIKQREKGRVGCMLGVDIKLLRKEKRKEERTAAELKRKEDLLENSSCSIGHFEMEDKEHEDSQKKVINQDNSEDDIYFISESQQGPSSNKRGRKTLMTPRLAAALDKCKVSDRDTMHIISAVLEALNIDITEFVLNRSSIKRNREILRKIKYSSIKSVGNDANFIEVHWDSKLLPDITKNEKIDRLPVIAVGLDFEQLLGVPGIASSAGSEVCSAVFHITDEWNLTEKIQAFCFDTTASNTGRIKGAAVLLQQRLGRDILWLPCRHHIFEVVLAGVFTRTKAIVTSGPEIAQFKALKENWKNIDKMKFLDYTSDEAVYNALKDVAPEIIYFVKQKLAEEQPRDDYKEFLQLTLIFLGDKTNVSFRAPGAYHLARWMAKAIYCLKLFLFRDQMKMRKDNSKLNAEICVFVVYCYVEAWFSATNTTGAPLNDIYFLRKLVIFKNINENIATIAITKFLNHLWYLSEECAAMAIFDDRIERVEKIRMAQKIMECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JN38</accession>
    <name>A0ABM5JN38_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499350.1">
        <property type="nucleotide sequence ID" value="XM_050643393.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643393.1">
        <property type="protein sequence ID" value="XP_050499350.1"/>
        <property type="gene ID" value="LOC126879968"/>
    </dbReference>
    <dbReference type="GeneID" id="126879968"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="125"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="345" mass="39927" checksum="0A9AFEF3CE27F736" modified="2025-10-08" version="1">MPQLRKDDKRCYIYFRMTIDCFDELLHLVENDIRKSDTNYRQAISPEERLAITLRYLATGDTFYTIGHSFRVGFSTVSAIVVEVCEALCRNLQHIYLPEPTTEIWKKSEEGFRNTWRFPNCIGSIDGKYVTIKCPDKTGSNYWCYLNKFFTVLMAIVGPDYRFISVDIGGFGKNSDGGIFEASNMGRRFETNQMGVPEPKNLPGQNELSPHVLIGDEAFALKPYLLRPFPYSQSRTDIFKENYNVRLCKARRVVENAFGILAQKWRIFYRPMETKIDTSILIVKTACILHNFLRTKKCDDRFIELLDPPEPELGAFQNLDNDPRRAARLAFSVREKFATYFNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JN68</accession>
    <name>A0ABM5JN68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Neither inactivation nor afterpotential protein C</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499381.1">
        <property type="nucleotide sequence ID" value="XM_050643424.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643424.1">
        <property type="protein sequence ID" value="XP_050499381.1"/>
        <property type="gene ID" value="LOC114345834"/>
    </dbReference>
    <dbReference type="GeneID" id="114345834"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF2">
        <property type="entry name" value="NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="15"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="328"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="421"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1509" mass="174292" checksum="DA1F723F65257E9C" modified="2025-10-08" version="1">MKVDGSDIPAPSDRYEISDIVGYGVYGKIYIAIDIQASKKKVAIKCQKYETGCKEFVEEEYKILKDFSSHVNVVDFYGIFKKGNEIWFVLEPCEGGSVIDLVNRLFAKNRRMVEEHIAYVIKETVRGLIYLHENKIIHRDLKGSNILLTKEGEVKICDFGLSKIRSQMDEMLSVILGSPSWMAPEVVSVGTKQISGYNDRVDVWSLGITAIELAEGKAPYEGMNPSRALFQIVANPPPTLRKVSTWTENFHDFIGECLVKDFEYRPCIMEIIEHPFLEEIPENNYHLTMELKSLISDVSAIKLKPKTPDVVVHGKFLKKDIDADLEPMYEEDLAALHPIYERDILELLEKRAEMGEYYTYVGDILLSLNPNERRLIYGTEFHEKYQFKSRSDNAPHIYSVADTAYQNALHHKTVQQIVFSGETGSGKTSNYLHLIDHLFYLGENTSVSSSRIKNAVQLLHSLMHASTPSNNYGTRAVFKTEVNYGKTGKLSGASFKIHCIEKSRVSSTDMLQSNFHIFYYFYDGITSTPMYEKYKLRTNRDYAFLRTQKKSKTNTPRDDVAANIIKYKKLCGYMEELQFSSQDISTIHSVLAAILHLGDIVFEENKDTVAVIQNKQEVEEFSDLLEVDPKKISWALTNYCVIKDGNAYKVRHSSYEAIEVRNVLVNTLYARLVDYIVGTINNKLSFGKAIFGNNYMVKILDFFGFECFKDNRFSQLLVNTFNEQLHYHFLQRVFAWELQDLQEEDIDFVPLNYYKNKDTLNEILGNSEGLLAIIDDASKKGHRGRYITDNIYNEEKRKILVYDEDRFSVVHYTGKVTYNCRKMPDRNRDFLAPEIIETLRNSRNPIISLMFTSKLDRTGNIILPSEETRRTKYVFGSKMAMEREYSQIKKMRTQSTVFRSLCIELLRELSVGAGSGGTHFVRCVRTDLKGVPRNFKRELVKHQLRAMAVAETAKIRQNGFSQRISFPEFLRRYKYLAFDFDENVDITKDNCRLLMIRLKMEDWALGKSKVFLKYYNEEYLSRLYETHVKKIIKIQSILRGFLVKCRMAKQEKKDKKVVVEQIKTTRRDSLMTEDEAAEVIQKAYRNAARRKEVLESYRQLEEEDKTFIRPFARKWKSQSLFSVLMRYRAKRVQDFFNLSQQVHLYNMNSYHKLQQTKEGIDLNNVDDKAQVGSYLDEISNSVLKLYFRLEDIPFYNTSYMSDLLTNIGDIRTKEESWDSPYRWRESRFQTNEESTDDDLDTSDALANTNYRREPDEDIVPLASPVESENGKEAKDMANEDIKAYGRKIADPKVTFNIAANGETPYKANLRKIEDSYKNKPTPYFLKNTSPANKDFEFIKATPVSIKPRYHVDPVEELKNISRKDSNTTDDDPPFNFQGMLRKTNFRRDSLKNAVQTIRKLSLTKETLEVGSKISKFENNVQKPTEKIAKDNHIKNGHTNGINSIVNHVDSTPSKYIDMNDKQDSIPIPGCSKENSIDQGLAAENDVDKGKLVKVEIGPGLILEGIEFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNA9</accession>
    <name>A0ABM5JNA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499423.1">
        <property type="nucleotide sequence ID" value="XM_050643466.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643466.1">
        <property type="protein sequence ID" value="XP_050499423.1"/>
        <property type="gene ID" value="LOC114332545"/>
    </dbReference>
    <dbReference type="GeneID" id="114332545"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="566" mass="66195" checksum="255E283DB8853C9A" modified="2025-10-08" version="1">MATLQSMLVKAEIKDEFEDDSSSRHCIKSEPSTSHDLGDLRIEPETVSAVKAEAEIKDKFLVDDSRDIKSQPLTSFYLGGSGNEPDAKPAVKAEIKDEFFEDDTRYIESQLSTSLDLGELKNEADEDNSDLLDEENTSENMKAISVHSCNKEQLMGRSVEEKTLKDFPDEKNTSENMKAISVHSCNKEQRMGWSVEEKTLKGEICFKQPDHRRSLNKHRIAHTGEKPYKCEICFKQFTTTSMLKRHLITHTGEKPYKCKICLKQFSQKSNLKTHLRLHTREKPHKCEICLKQFSQKCDLKRHLITHTGENPYKCELCFKQFTTTSMLKRHLITHTGEKLHKCEICFKRFFQKGNLNTHLKFHTREKPHKCEICLKQFSQKSDLKRHLITHTGENPYKCEICFKRFSQKGNLNTHLSWHIGENPYKCEICFKRFSQRGNLNTHLKSHTREKPHECEICIKQFSLAHELKTHIKTHTGEKPYKCEICFKRFSQKGNLNTHLKLHTREKPYKCEICFKRFSQKGNLNTHLRSHAREKPHKCETCFKQFTRVSGLKKHMRLHNKEKPNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR72</accession>
    <name>A0ABM5JR72_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500436.1">
        <property type="nucleotide sequence ID" value="XM_050644479.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644479.1">
        <property type="protein sequence ID" value="XP_050500436.1"/>
        <property type="gene ID" value="LOC126880548"/>
    </dbReference>
    <dbReference type="GeneID" id="126880548"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF69">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21370" checksum="888630299385128E" modified="2025-10-08" version="1">MGCFGSKDKLSKEDMDFLKSHTRYDESTIKEWYKGFKQDCPNGRLTPAKFVDMYKMFFPSGNAEEFCDHVFRTFDMDKNGYIDFKEFLLAIDVTSSGTPEEKLKWAFRMYDVDGNGVIDIQEMTKIVQAIYDMLGACSSNRPADSAEERAKNIFAKMDENNDGQLTQDEFLKGCLQDEELSKMLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRG9</accession>
    <name>A0ABM5JRG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500534.1">
        <property type="nucleotide sequence ID" value="XM_050644577.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644577.1">
        <property type="protein sequence ID" value="XP_050500534.1"/>
        <property type="gene ID" value="LOC126880600"/>
    </dbReference>
    <dbReference type="GeneID" id="126880600"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="316" mass="36758" checksum="0D9CAE69132B8FDB" modified="2025-10-08" version="1">MLIHAEGKSLHCGICFKSFFHASDLKRHAITHTAQKPYQCEICFKSFSQNGYLKAHLSYHTGEQLYQCEICSKSFSHPSILNTHKRIHTGEKPFQCEICFKSFSQSGAMKKHMRLHTGEKPYQCEICLKSFSQTGDLERHKQMHTGIKPYECEICFKSFSRNGYLKAHIANHTGEQSIYQCEICLKSFTHASSLRTHMRIHSKENPHQCEVCSKSFAYASFLKVHMRMHSDEKPYQCKMCSQSFSSAGTLKGHIKTHTGERNYRCDICYKSFLKSFDLKRHIVVHSQEKPYQCDICWKSFFRSDSLKKHTRLHTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRS4</accession>
    <name>A0ABM5JRS4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein GDAP2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDAP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500642.1">
        <property type="nucleotide sequence ID" value="XM_050644685.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644685.1">
        <property type="protein sequence ID" value="XP_050500642.1"/>
        <property type="gene ID" value="LOC114331990"/>
    </dbReference>
    <dbReference type="GeneID" id="114331990"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02905">
        <property type="entry name" value="Macro_GDAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035793">
        <property type="entry name" value="Macro_GDAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF72">
        <property type="entry name" value="GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="3">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="338"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57897" checksum="600847A5BE46251D" modified="2025-10-08" version="1">MRLKMNQEPLGVAPDYVLPQSLTRWSETLPSQHLTDYSTVCETRHSPYPFPCDSNINNRMILWSGDISSLQVDAIVNSTNETMTESNPVSDRIYQRAGSGLKEEITLDIRECGTGEVRVSQGHALPARYIIHTVGPKYNIKYKSASENTLHTCYRNVLQKAKEMGLRSLAIPVINSVKRNYPPDEGAHIALRTVRRFFENHGSSIDTVIFVIDKVDLGIYEVLLPLYFPRSKLEEESARYQLPSDTGGPDGEPIMPDRQIRIIDNPQHALHHEEESVDLSVQLETSINVGDHVFSQMQGDLDQQRLLGERPFNDPLADIMVKEIQHQERYERLLRRAKSEDLTEVSGIGCLYQSGVDRLGRPVVVFIGKWFPFNKINLDKALLYLITLLDPIVKGDYVIAYFHTLTSSNNYPSFSWLKEVYNILPYKYKKNLKAFYVVHPTFWTKMMTWWFTTFMAPAIKQKVNSLPGVEYLYAVMSPDQLEIPAFITEYDMTINGIRYFQPVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSB5</accession>
    <name>A0ABM5JSB5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
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    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050644880.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050500837.1"/>
        <property type="gene ID" value="LOC126880816"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR45749">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
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    <dbReference type="Pfam" id="PF14291">
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    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500837.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="646" mass="74476" checksum="11AE3F22BDCE7EE6" modified="2025-10-08" version="1">MKSAGKNKLGKLQQHFSSMAHKAALSDYCNFLITERHIDVFLDKNKRNTLIEQEKIHSQNKRVLWVLMDTIRTLGILGLGFRKSDSASEGNFGQIVNLISRHNSVVKQWFDDRKLRPYHVTYMSGESQNEMISLIGSEVRSLIIEEIKECLFFSIMADTTPDLSHKDILSLVIRYADNKGNIHERLIKTVECCDKSGLGMAELLIKCLSELEIDSSKLAFQSYDFASNMSGRFNGVQKKITDIVEHNVPYIPCQDHRTNTVLEHACNVSALIRNFFDTLEELYVFFTSSTKRFKHLQEKIQEIDKSVQLKNLSRTRWTAKADSVRALNQRVDQIIEVLSDISKNREFDGSTRTKALGLYKKILNFDFIASFFFLKNILPKIKILTETIETPNLNIIDCINLIKTTALNLRNTDYDHNSLNSLIESAIKYAEKLNIDPYSDFSKYHRRRIMPKKIDENRDTEVDMDLKTFYRRDFQEILDTLSSGLNDNFEHIKKSIEPLYSVLTFPLDKRNITLKILGDIVAMFPPGSKKPDVHSLQGELEVLFDMNSKVSSFPELLSNVTKLKDNLNQAFCFCMFVLTVPYGVSTNERSFSQLKIIKNVLRTTMSDERLDNLMLLKSESDMALKLDLGYTIDKWATLKKRRIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUD7</accession>
    <name>A0ABM5JUD7_DIAVI</name>
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        <recommendedName>
            <fullName evidence="11">Cytochrome P450 4d2-like</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Chrysomelidae</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
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        <property type="nucleotide sequence ID" value="XM_050645596.1"/>
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        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
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        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60502" checksum="0D5745BF37751D59" modified="2025-10-08" version="1">MIGLGIIIVVLFIAFYFYQQSRRNTKYMRNVPGPKPNIFFGNLLEFAFIPTHKYLDVFLGFIRDYGKLVKVYDGPFSMAMIATDEKFVEHILSSTKYIDKADQYDYMKGWLGEGLLTSTGAKWKKRRRMLTPAFHFSILENFLEVFDSVGDIFIQKLRREVGKKTVEISEPVSLYTLDVICEAAMGIKLNAQTDSTSPYVRSTRSMCSIIVERILSPLDPSLYPLTLNYYREKIALKVLHAYTDSVIDKKISEKKKKTEILVDKNTNIGIKKKQAFLDLLLDYTMDGEPLLRTDIREEVDTFMFEGHDTTSSAISFAIFALANHPEVQGSKIFPKHSTVVLFYLQFIFNGIFILSENQEKAFMEQKEMFGNFSDAKPTVSQFQDMKYLDLVIKETLRLYPSVPVLGRRLPEDMEYDGHLLPKGMNILLSTFAMHRCKEYFPEPLKFIPERFEDAKLTNPYVYTPFSAGPRNCIGQKFAILEVKSTLSKILRNFELMPATPVHELQLAPQTILVSKNGIRISIKERS</sequence>
</entry>
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    <accession>A0ABM5JUF7</accession>
    <name>A0ABM5JUF7_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
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    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501572.1">
        <property type="nucleotide sequence ID" value="XM_050645615.1"/>
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            <end position="210"/>
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            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
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            <begin position="150"/>
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        </location>
    </feature>
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            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
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        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501572.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="27638" checksum="249EEA3E53A3860B" modified="2025-10-08" version="1">MEINKELQNGKYNDRMGISEKTYALQIYNNAKHLQYNYSSEQLVELIARHFEETLEDHITLQNYKDIDSLCQFLQIRESRLRERKSRRSQEDYRHQEPQDYTDRRQNYSRDYTRRDSNPRRENENRDNGRGNYEQRNRQWNEDRNRENQNRNTTRTNQENRNNGRQNEQGYRENRNRSDRPRENRREVNNTQTEEYDKERHYDDNINNEEQPARLAFFHEGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUN2</accession>
    <name>A0ABM5JUN2_DIAVI</name>
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        <recommendedName>
            <fullName evidence="6">Mucin-2-like</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_050645687.1"/>
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        <property type="component" value="Unplaced"/>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046883924" description="Mucin-2-like" evidence="3">
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            <begin position="21"/>
            <end position="2503"/>
        </location>
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            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1536"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1642"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2370"/>
            <end position="2388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2503" mass="270532" checksum="D3EBA60256319470" modified="2025-10-08" version="1">MKMKLLPLFLLFFFILLTQAQRRTTAKTSTEPSTTRSSVSRGRGRSRFVTSVEYQNVRETSSTPESVPRKTVTSRRRVVENVEQRFPSRSVSTPSPTPSKPAITFTVNSERRALAPTFGDTVEKIFTVNESPIKRTSKPAAVPQISARRTPKPLTDYVERKNFKSTKNTYEVQEVINEDFELVRRVKKPRVLIESTNNQVSVPLRSIDRKEFFRTGSVSRRNQENADSVLATKFPKRTKDTQEGVLNFPPRKLENLEPPKSTTSEAPVSEEPINNISNGNLLEEQPLDTTLVPVEFESSPDPLQAEEVKEELTNVNLVSSTSKPIEEPRSSANRRNGLRKNTNVIEQSTAAPRFRTRGRSSPAAQAEQSSRAPEFNFQSVTPTATPNRGFRRRLDTITEPRKGPSVFSAETQFPESRSRTGRKIDLPTPEKLTLEIPTRNRRRTTTPKINKESSMPTFPSRNRFRSREMPIIDEQKLEVLPLFEVEPKLVNTRVMNRADVVFQPKKSKDKDELMTRKINDIDARSRRRGGLELIQASSTEIKSTEIPARSRVAVSVSVETRTESSVRRSIPNRRSEVKESVVSEINEVTSRKKVSRKKVNSNSSNEIKIKPLPVYRGSKKSDVVVKKGSSEEVDESDNYPEAFKALIKSKKESRPVPSSLPLRASNVVTSVPSFSTTFHPSTFKEVTDSDNEIKPKALPTSTSSRWNRSRSTTTSSVKLSEPLPPKRFPSRTSPYTTSEPISEKRFPSRTTPSVSISTTPIYRGTKLRTLTPRTFSAPPKLEKSVSFKPRSSVAEKNIEIKQFNRNRNAKRAENPVLLSTKVPKYTTTAKKLDRGKYRSEYSSRGSTTTAPKYIPTIPSVPYIPTIPAITPVRTMVDTSNQKDHDDGIHVISIDEPVNALQSANLVKGDFVSSTANSVSDILPLVNDGTTEKTVSIIERIINSISARSTTPPSSGTPFSSTASTTESPSAILKLSPKKSRQTDLTDSSKTTESNDTVPFTTENPTTIIEKILSSLNAIQATDITSAGQVGIDFNTLTSFTTTPVSSVTKSSTSRPLLAPSSTTIFPLSILDELSEENKQKETVRKLLDLLNGLVSPQQQEVVVTPKYVNNRTPGRGPFVSTTFFPLSTASPELTTAPTVSSSTSTEQISSNFILSENTSPQIVSEIPNTTETTVTISTSTEVIPTVDSQSTTSLEELASTESATSNTEIVNSSVNTIIENIATNSDSPSTIGTTTENFTPSIPAGTEFGTIPIDVSSFFTTFTTPSSFQRFEVSPGSVSVFSANDLSLNTVTLEDIISTTVVNIAGRSNFDNAATTTSATTKEATKENTLEITTVGITTEPSPQTSSDSMSTSTEIVNSSNSTSSITETVNSTDPMSSSTETLSSSGPMSSSTESMSSGSMSNSTDALNSSGYMSSSTETVNNTQTNGTRSSKKLNFIQEPVQNRIDTSTPDYFIFAVLNNNTILRKRPKVEPNAPFYVIGVYPNNTVVKKFPNGTEVPMDMIIRVRGFDTRENPPPLPEITSNQVTSDLGSSPENININTDDQNTIPSVDVKSNRVAASTTQATTSSTKAQTTITQSPITTTEAKSRTTLSEISTTTPPITSTSTVTPSNTQTTIMSKAEPTTIPSTIPLETSNTSSLPFSTEQSSTTSTSTLPSTTVLNSNTVTLPQDSINASTLDLESTKLTATESSTNTLSTSDSSTAEPDLVVVESITVLSTTMGSNSVPPTFPTLSEILNDKTLEAFNEIVSNSDQVNTNISNQTDNGRVSKYIKVLNIQDLIKGRNSEARSRGKPISIKVGTTIPISNEIVSTESSSTIKSTMSTEQAISTTTNTVTSTTSTPEVTPLKSEETSTEDNAILSNKILDDTTLPAKPTPFSAIQKIGTTRKLTPTTITPIFISTTPSVFPTFLTTFFPNLFPDEATRKPKVSTSSPGVIRISAAPSVTQTTFTERPVTTTQAVTTTRPTTTTTTTTTTTNAPTTTTRPPTTTKIVTTTTPATTITTPSTTPKPTTTTTIPTTPQPTTTTRMTTSPTRVTLGETVTVSTTGRTDAITDFNTIEVTTTAIKLKGLSSEQKNNLREIAQLEKEQAALLQQLSFLTNLGLGQNRGPKSVANDKTKNSNANPASSLAERILALAVQRDKNSKSTSTVATTVTTSSTTKLPTSIQDQIAALETTKAPTKATPVLEEVLKQYNLNGLNVAVTSPTSTVYGKSEDAILASLLKEQGIVPSTPAVLAGVFDETTIRPRRPKATTPQPGPIMRGLNWLLNTLAPTPAPATKRPTPKPVKPNKPPVEEELLVNSPTHMTPIATAAPSKIANALSQEDIKKLINQLEDIQKNPSKGTLDLSQIKSIQNLINLDGGVVVSTNGEHGTTSRITTTQSTTPTVQTTQRQPKKMVTLPTEDPLSAISSSEDGFGFDSVESTTRTLRAPVGFNPVPGVDDGSPNPLVQSNLITAAVNVTKAISNFLGTALQTVSQGAAASFQTLFGVSSVGTRVLGSASGGSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVB9</accession>
    <name>A0ABM5JVB9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501879.1">
        <property type="nucleotide sequence ID" value="XM_050645922.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645922.1">
        <property type="protein sequence ID" value="XP_050501879.1"/>
        <property type="gene ID" value="LOC126881578"/>
    </dbReference>
    <dbReference type="GeneID" id="126881578"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="594" mass="69156" checksum="A0B51A2A827587BB" modified="2025-10-08" version="1">MSTEFNELCRVCLNKKDGMKYLLKLTHDISEVLSMLSSIISFEVNMLDGFPSYICVNCEEKLRISYDFQQTAIKSQQIIKEYVDNKLLSVEFPINNEVKEENCAPEVIEDISIIFENDSSSSSEDDSQETLKKEEKKAKLSQHDPEEIMSIVNETRLKFYEAKECLLCSFTGINNRTLSLHMTKNHGDIKEKWCRKCNKIEENLSEHIKTVHRDELKCSFCGKKCRSSTHLVEHLLCHSANPQFTCLTCQKNFISERQLKSHTKIHKVTCEVCSKTFEDKHSILAHTKLHNMLRCTICNDTFGQKEYDKHNCSMKELKNEKQSDILLDRFCLQCNESVEDINNHIKTHHNVEDSVKGLCTFCGKQFKNQSYLSVHLRRHTKETPYKCNFCNVATVTKAHLQEHERTHTGEKPYTCNFCGKAFIQRSVLSTHLKIHTGRTEQCQLCPKKFCRPSELRNHMRKHTGEKPYACTYCHRPFIQKSHLTEHLKTHTDDRPFKCHICDKAFKQSGTLKSHINIHEGKNIYKCDMCPYTCRKNYTLTLHMRQHQANNSDPVKCDGCEEVFPNEETLTEHRHGCTMVCDDDKATLYDEYLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JX12</accession>
    <name>A0ABM5JX12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502477.1">
        <property type="nucleotide sequence ID" value="XM_050646520.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646520.1">
        <property type="protein sequence ID" value="XP_050502477.1"/>
        <property type="gene ID" value="LOC126881871"/>
    </dbReference>
    <dbReference type="GeneID" id="126881871"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="728" mass="82873" checksum="C92818A2E13154F7" modified="2025-10-08" version="1">MSLAIDAVKNEGMSKKCAAKEFCVPRTTLKRRLENNCLKRKMGPKSILSEGEEKLLANWILSMGRKGFPVNATNLISTVHKIMKETGRSTVFKDGMPGKTWFAAFLRRHPEIKKRRAESITKSRAAVSKADIEKWFNEIENYLKEEGMIDILKYPNRIYNADETGFSLDPKSGIVLGPAKLEEDFYERKSNAEKEQITVMACFSADGITVPPMVIYPYKKIPKDIVNSAPPEWAVGRSDSGWMNSEVFYEYIGNHFLPYLKEKNIPQPVLFFVDGHRSHLTKQVSELCEASGIILVALFPNATHILQPADVSIFKPLKTGWQTIVRTWKFENFPKDVTKYTFATILSTVFKKYATESTIRNGFRKCGLFPFEKSNVDYTKCVSTRQVVDPTNLSDIKNTIITKGNILSELEKKIPPLELNHFRTNFDNKDDWKGDLQFKKLYEVWAEFKNEALLVTNKHKHVTGEDDSNLMEGNEEMSISFSVPTASTSTPNGKQREESVILPNEEQSQNGNSTILQDKSTTSLNVSESFLSPDKLENVALYKDKEDQGYVVSTPFKKCLIFPKTPEKEPPKRKRKIFPAVVSTTLYRAHYDNITSKSGPSKQSQIKIKKPAVKRKVISESESSADDVPYCDEDLDASDVENYTIKNIHDGDFVIIKYNGNLYPGKVIKANQEGAEVSSMEKAGYDWKWPEKEDVLFYFYEDIKKIIREPLVKGKRGYYSVPELSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXQ3</accession>
    <name>A0ABM5JXQ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 140 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502721.1">
        <property type="nucleotide sequence ID" value="XM_050646764.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646764.1">
        <property type="protein sequence ID" value="XP_050502721.1"/>
        <property type="gene ID" value="LOC126881999"/>
    </dbReference>
    <dbReference type="GeneID" id="126881999"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056156">
        <property type="entry name" value="TPR_IF140_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24760">
        <property type="entry name" value="TPR_IF140_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="8">
        <location>
            <begin position="3"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="9">
        <location>
            <begin position="435"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="805"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="IF140 C-terminal TPR" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1484" mass="167267" checksum="A19662928BCDF5D9" modified="2025-10-08" version="1">MTLYFERPVVFPETGSISVNSVWHSNTPLLAVASFSQDRGGFVIIFDELGESLKNVNYPVHRSYQVTALSWHPNKIILVTGWENGELKIWNGSDKDFANVIGPHKAPITFLGFSEKGTRLVSCDSTGSVIGWKVDSRGDTNLSFHLDLKESITHLTFRRTVKTHIEFDVEGLAKAAVNGDEHALDMFSNWRPKTTARKFKVQDGADNVNFFVATQSGSIYYINTSGSCSEVFNAEGIPMSNILYHPSKDAMIVMIEGFTICYFSVDYQGHLSELAKVKLSGRVQTRNVGSQGITWAGSSCLAILTGDLTVRVWDIETNDNYVLPTQMKLYDTQDKYHTVNEIFTCIAYCTLNQTLCAGTNIGRVYFWGKKHNFTDLENPEDIWDLNNVNSISGTIKQVIWGSQMLRLPLLSVNCVTSVYIMKEQSICSTFSERIWATQKTSSQVLVESDKGDFLLQLDSQVTDMAISKEILAFTDGRSIQCYDIVWETVNIDRVESSLNEGGNKDFSVRRLSTFTAERDSIIVYHKNIIAMDAKSISIFSTMGSILFTIAAGMNEGENIGMDVSSNYLTIFTMEGFLKIYDLSVDPPKLLTSVRSMYDMVPDFGEIILAKTNSSGTKVAFTLAAANLIPDGKLYVWDIESDTVTFYDFRKYDSLESHKIRNEEESQEKTKAEQKMDDNCKNRIPVGFCWDEKDSRLLICSARKLKRLVQKKGFLARTKSEEKKNLSDEDSLLITMFVSPENSIRLHDIKPTELEIKLLACVAPFIVSVQKLSIVRDIMSDFVGLENCDSATSKAVLDFSYHLSLGDMDAAFKSIKLIQSKGVWHSLAKMCVKTKRLDVASVCLGHMGNACAARALRLAVADGSLELEAKVALLAVHLNMPDEAEQLYIQCGRYDLQNKLLRSRNKMDAAHAVSESKDRINLRNTDHTWAKMLEQAGDFKEAAARYERANTHLYDVPRMLSDHPQQLQTYMSKTKDKEMLKWWGQYVESQGDMVSALKIYANAGDIYSQVRVLCFMGKETLASELARGNMQDKAALYHMARYYETVGNFEEAINMFTKATAYCNAVRLCKENNMIDELWNLSIVVSGKEKVQIAKYFEEQGDLEKSAMLYHRGGMLHKAIDLAFRTKQYDILQEIASELNADSDPALVRKCAEYFIDNEQFDRAVDLLAIVKKYTEAINLCMKHNVQLTEDLAEKLTPSKDLVDEDTRETVLETLAESLMVQGNYHLATKKFTQAGDKIKAMKALLKSGDTDKIIFFAGVSRQREIYIMAANYLQSVDWQNHPEFLKNIITFYSKGKALDLLANFYVACAQVEIDEFQNYEKAYGALTEASRCLQKITEPRDPKQIQRAADIVQQRITLVKRFVDIRKLFERGDGQTAVTQCQQLLMTAGNDLEVAVRRGDVYSSMIQYLVKSGNYSEAKQYFVELRHLLEQSGNTPITYYVTNEVLEGLANGLSVPVAQLLPKSTKMRVASEGDGDDVEEVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ20</accession>
    <name>A0ABM5JZ20_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050503191.1">
        <property type="nucleotide sequence ID" value="XM_050647234.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647234.1">
        <property type="protein sequence ID" value="XP_050503191.1"/>
        <property type="gene ID" value="LOC126882337"/>
    </dbReference>
    <dbReference type="GeneID" id="126882337"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046293712" description="endo-polygalacturonase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="353" mass="38575" checksum="0B7A591E6BCA9AC8" modified="2025-10-08" version="1">MLFIYKILVLLIVVSIAASDICTISNYDQVDEALSSCKDIVISNLTVPSGKTLNLNLKERSTVTFDGVITFEVSFRTGFLVSVAGKNVLVQGAPGSILNGQGEKYWDGFGDNGVVKPKFFRVATSGGSIFRNIYLLNCPHFCVGVYATDVTLTGWTIDVLAGNTRGGLNTDGFGIHSGKNIVVQDSVVMNQDDCVVVNSGTDMIFRNLQCYGSHGLSFSVGSKTEENAEAGIVQNITFLDSLVANGLYGIHIKTKKGSGTIRDVIYENIQLSGITEDGIYINQDYEDIGNYSREFEIHNLKISNVYGSIQGLLTRPVHVVCNENKCSNWTWSNINILGTRKSYCNYIPDGFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZX6</accession>
    <name>A0ABM5JZX6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503493.1">
        <property type="nucleotide sequence ID" value="XM_050647536.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647536.1">
        <property type="protein sequence ID" value="XP_050503493.1"/>
        <property type="gene ID" value="LOC126882565"/>
    </dbReference>
    <dbReference type="GeneID" id="126882565"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="388"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="482" mass="55211" checksum="4B32967FF450C6FD" modified="2025-10-08" version="1">MSLEKAINLCKSIESSKIQSEKMKSEEVHYVKKRNFNKKYENREQWEDRRVNPTHSKSQDGQFNGKSGSSLGCSRCGMEHRGQPCKAYKAKCLVNTKNSSFDDDFMINFEVNKRKLSCRLDTGAMANVISINKLNSLEVNVELQKTNCKLTTFSDETLRVIGKCSLECKYKDNMYNIMFYVVEINSPTVLGLPTLKKKLKEGVRTYYICHRSQAPQITEPPKRNAKSMGTNKIGRTCPSTMIVTSNQECISVVFFPVHVGHYNELGRLRIDETDRIKIAGKLSQGVPIGRVILEKVHPVERVHLIEKKDLTNIVRDFSIGYTIKRHKNDAVSVQLWVKAMQLLENNPVLFYKNSEEDDEGVFDKNDFVLIIMTEVQKKSLISFCQDKICIDGTHGLNQYGFQLYTIVIVEEYGSGVPAAFCFSNRSDETLFQHFFKCIKDSVGLLSPNVFMSDDYNAFYNAWKSVMSEVPNRLGTKFWKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0F0</accession>
    <name>A0ABM5K0F0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503665.1">
        <property type="nucleotide sequence ID" value="XM_050647708.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647708.1">
        <property type="protein sequence ID" value="XP_050503665.1"/>
        <property type="gene ID" value="LOC114337570"/>
    </dbReference>
    <dbReference type="GeneID" id="114337570"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056707">
        <property type="entry name" value="DUF7805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF4">
        <property type="entry name" value="GH12701P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25090">
        <property type="entry name" value="DUF7805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="132"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="955" mass="106943" checksum="B96FCAEE144F3487" modified="2025-10-08" version="1">MAKSGFLTFDSFTLGRFVSFTTDGCPDGALQISESNRPQVGGSWCGTSWGPAIYYSETKSVTVSVNLFRLSKVENGYNFDYRMEYKFLKRKAAIVRYGGSQPPSLFNITEPSTAADPEPEYYLGDLISGTYCSRIFSDCDRKHCRLQSPNFPGIYPRNLTCYYAVRQHEIPPGKHALITVRQPKGQLISIRSQAALFGTATPSEIKVWDACDDVQDYVTVYDGYTTRDPVILKFCGGGEEVPPAVSSGHELLVEFSSSPYGTFLHPTPVQALHGFQLEVEVTFVDQQSPSFTKQKRMCEFWVRGTNRGVLESPIHSVPANTTCLYHLQGLDASISPTPPPPHRTRYPDWRHVGMILPPPRYRVWLSVLKFHVASAWDPKKADQVCRSYLNVWDGQLWTPSNCDGLYCSSGKERSKGRQNTSGSQSSSTGGGSSKKNVTLLARYCREHVPRSCDHSLLGNATRFPRPCTLAESFLTSGDSLTLELKLADSTALKPVAFKALYEFVDLHLDGEPFGEGPCSRRFGNVASRTVGAGASAGMGGIDESQQFRSPRDVFLYGRGGARNISCVYRFEVKKDERIKITITEMIVKNRRCETVISKDTNQLECFGNTSATLRFYEVPWHDVPGVPKDCLCAVDKSRLIPFTYFSTSNVVELRFNVVGMNASDDFDTLFFEGHWKYIKTPSCHKNLRYRGASGEVTFIHPTPYDEANCESNPRVIIPGLNKYLYVKISGSIMKHSTRKGNSTLRTIITGQKCDHSNRIKVHTALYSALICPYESSYRQHLVEVFSEGWNIKKEDKAVDGIALDKIEIDRLGIELSKTIVLEFYGKEEAEYSVNWLELSRRRDVPPNGLGLFMMRPDECQYRCPELDACINASVWCDGVEDCPSGVDEAITHCSLILQLPPVYLFFGALGVILSSFLTGVILWKTCRRRPRSILQTRLKSLSSDTAIIDDRDIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K130</accession>
    <name>A0ABM5K130_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503894.1">
        <property type="nucleotide sequence ID" value="XM_050647937.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647937.1">
        <property type="protein sequence ID" value="XP_050503894.1"/>
        <property type="gene ID" value="LOC126882879"/>
    </dbReference>
    <dbReference type="GeneID" id="126882879"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045939603" evidence="1">
        <location>
            <begin position="21"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="647" mass="73252" checksum="9192E379F6F57CBF" modified="2025-10-08" version="1">MMKSAAFLLVLVIVCTGCNCEISSSASGNVSVSASASASASASVDISAVLKAFLGFQSSIVDSFKGVVSICFDFWKSWFQNVDFCIGSLLNIDLFKPVFSILADFRELIGSISITITEIANFFLNAFDELKHAITQVIIPSYPMTELKNIGDLYFVIVEIFKAFITTSISIWETFWEKLPPPPNVPEIIVNYYKALFQIFFKASSDNFINFLSTVTDAYSLVIHFISRIDDILVQLLSKLPFPILSNIRNAIQFVFGILEQIKYWYINIVDKIFWKLPVPAALADLAEYYLKVMLDFRSLLVSVVDFIDGLFDTYFASLKSLFLSLKYAIKSLLEYGFLSNPIYTIIIDFIEDVSTSIYQIDVTFSDVFEHWEYIILHLTIPSFELTPIRTIGDLWYGIVQTFIRISAALTNISVEFWESFPTAPKIIEIFINYYQSIFAIFNKTSLKIVINFLTSVDDGRYLVSRFISQIAGFLENLPIPKLPFLPYYSLDDVFNWIIELVELAEKNFWSLPIPDIFLKIATKCIEFIGNVHASFQFLAEFSFEGFLNIKNSILDALPGLLGGDAFYLSNDIGKLISSITSKLFPNLGIPVISIGTTDSYPATTATVPPTSWVPWTKPTPVTYPTRSIWPIFPNFTMPTFPKPWYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1N1</accession>
    <name>A0ABM5K1N1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504098.1">
        <property type="nucleotide sequence ID" value="XM_050648141.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648141.1">
        <property type="protein sequence ID" value="XP_050504098.1"/>
        <property type="gene ID" value="LOC126882991"/>
    </dbReference>
    <dbReference type="GeneID" id="126882991"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="373" mass="42279" checksum="12DBD3449C8C1DC4" modified="2025-10-08" version="1">MALSAKFDKVLRISSSIASHVWNGFSTMATDAKTPRILKRIGTHSGVFHCDEALACYMLRQLPEYADAEIIRTRDPKILDECDIVVDVGGEYNPKKHRYDHHQRGFEETISTVRPDLIKNKSIKLSSAGLVYAHFGFEVLDAILKKEKIPTNTECLRSIFVFIYEGFVEELDAIDNGVPMFTEGKPKYRINTHLSARIHRLNPEWNSPNPVPSNETFFKAMELVGTEFNERVIDSATVWWPAREIVKKSIESRNQVHENGQIVLLNERCPWKDHLLALEEDLGISGQIKFVIFHDAGDSWRVQAIPIQPDSFICRVFLHKDWRGVRDDQLSTISGIKDCIFCHATGFIGGNKTKEGALQMALRSLSAPVGDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K266</accession>
    <name>A0ABM5K266_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504283.1">
        <property type="nucleotide sequence ID" value="XM_050648326.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648326.1">
        <property type="protein sequence ID" value="XP_050504283.1"/>
        <property type="gene ID" value="LOC126883093"/>
    </dbReference>
    <dbReference type="GeneID" id="126883093"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="270"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36211" checksum="B46B0EF40F6A5301" modified="2025-10-08" version="1">MAIDPKKIITELSTVFKDDQETFARVLFYLTEEETVYKETDKLGPHMKMLMSTMEIASLFSQYAKRLAEDTKRADSDKKFKRVLGAIWAEMMDANKQTDDQDQIPDVNIIVKLEHLSLQAAPGMIRALSVIPYESQKLFLMMIKDIVPTTIVSKADFVVDTVNKAGGAVVTLALAGIQLTYEAIVNIRRWWEGEISGKRCCKNIIDSFAAVGGGIGGGFAGVAVGALGGPIGMIMGGISGGVFGGEMARILSEWMTKKIFDVPKSEALENAYIFFKLRNNASHHEINTAYRQKCLEHHPDKGGSSQMFHKVQMEMAVIKAAKGELYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2N4</accession>
    <name>A0ABM5K2N4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 12-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504458.1">
        <property type="nucleotide sequence ID" value="XM_050648501.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648501.1">
        <property type="protein sequence ID" value="XP_050504458.1"/>
        <property type="gene ID" value="LOC114332325"/>
    </dbReference>
    <dbReference type="GeneID" id="114332325"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043195">
        <property type="entry name" value="TTC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="28624" checksum="9ECD2F1F8566539B" modified="2025-10-08" version="1">MSKLYNSEYLCKDEEFNNFMVKVSEVNNIVQKLASKDKQIQEIGNIEAQRYLNDDGQNLNVDDNVELKVKNARTLINKKVLENEQKDPNSMSQEAFMKEVEKDADKRYTDKLVRKEKMETFKKQATLAFRRGEFEKALTLYNKAIEQIKDSVLLYNNRALTYINLKLYERAQEDLKLALRLNEDCLKSWLLLIKINFLQNNKEGYERDIREVLERNPNDKDFITDYINNLQSEYKHSEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K415</accession>
    <name>A0ABM5K415_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504926.1">
        <property type="nucleotide sequence ID" value="XM_050648969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648969.1">
        <property type="protein sequence ID" value="XP_050504926.1"/>
        <property type="gene ID" value="LOC126883421"/>
    </dbReference>
    <dbReference type="GeneID" id="126883421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="87"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="497" mass="58178" checksum="CA25425E52761CC5" modified="2025-10-08" version="1">MQFLYNSDSDEDYEDSDVDNFEIENVSEDSSGSDTEDDVLQNELNNTVADNPDVQITDNEWTETTSGMKQIPFTKRSGLLVDSPGDSAYDWFRLLFDDELLNMIVLQTNSYAVEVLSTGKGCDRSRISLWKELTISELLIFIGLTFHTGTIQLPSVQDYWKKNRLFSTCFSSYMSRDRYLLIMRCLHFAENVKENEPVPVDRLYKVRPLLDHFNNKMKTVYYPGKYLSLDESMILWKGKLVFKQYLPKKRHKYGVKLYMLTEADSTILDIHIYAGAGDATAGKSHTERVVLHLMRNFFDHGHSLHMDNYYNSYNLAKLLLDKNSFCTGTLRKDRKGCPKNVEDAKLKKGQTKSMYLNNVMVGKWRDKRDIIYISTEYKNEMVTVKNRRGDEKIKPLPIIQYNKYMGGVDLQDQMSSYYPPTRKTLRWYKKIGIHLFQLYLQNAHRLYNKYHGNNKMSYYKFRLSILEKLLHRKMSRNSSCNGRSSSYFGCKPHTFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4V4</accession>
    <name>A0ABM5K4V4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505217.1">
        <property type="nucleotide sequence ID" value="XM_050649260.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649260.1">
        <property type="protein sequence ID" value="XP_050505217.1"/>
        <property type="gene ID" value="LOC126883608"/>
    </dbReference>
    <dbReference type="GeneID" id="126883608"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21367" checksum="ED03518F37388E5A" modified="2025-10-08" version="1">MNYHIRPLSQHQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPDNIVRSLWLGRLPSSTQAILATQAKASLDAVAELADTISEAIARSVHISEASNARENTIDKLTAELAEMKMQLATLSQTQAQTNTYRRNRSNSRGRPYPRDRSYRRERNNDICWYHYRFGDQAQKCSLPCKHQENIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5C4</accession>
    <name>A0ABM5K5C4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505390.1">
        <property type="nucleotide sequence ID" value="XM_050649433.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649433.1">
        <property type="protein sequence ID" value="XP_050505390.1"/>
        <property type="gene ID" value="LOC126883768"/>
    </dbReference>
    <dbReference type="GeneID" id="126883768"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1250" mass="144993" checksum="4B190BAE1433E123" modified="2025-10-08" version="1">MNTCSRCDKSYSRSDSLSRHIKKCKYGNVDSDKNGDYYIPKKRLRPLGVEVIDSTVSKLSHAFKNRIASYRFNSGKKLDYHGFLNDVKPKVLNILSEYLHQHNIIKVNFEIFGIYLKPDTNLSDIKSMNTCNKIITISTELDEVFDHFKEELMTQASEFQEKDSNWLLQEIMFLDVNINKYSSISASTYIRLPIPIVRKHAILNIENKDNKCFAWSIIAAIFPASGNPTKPESYPPYDALLNFEGIDFPMKLKDIKKFETLNNISVNVYGLESNFVNNKRQYEIVGPLYFTSNRHATHVNLLLITNDKQSHYCLILDMLRLVKSQKTSNHRKEYLCDGCLQFFVCEEKLHNHQNNDCSHIYTELPTTKPKINKFGEMVPENILKFINIQKMLPVPFVIYADFESLLKPIDHVEPCNGNSYSVKTAEHQAYSFAFYLKCNYDDSLSKLIKYEGQDAPKVFIQKLDDLVHELYNNHLKHIKPMSPLTKEEIEKHESATECYLCGKPFNPFNRKVKDHHHLNSLYLGPSHNSCNINNKLSNTIPVFFHNMSNYDCHLFIKELSTTGEKVSVIAQTKEKYITISKGILVEKSKNGLDKYITLKFVDSYRFLAKSLDILSTTLNSEQCTEIRKYFPNTKHFELVRHKGVFPYSYMDGFDRLKEKTLPPKENFYNNLTNKHISDEDYARAIDVWNTFDCKSMSDYAMVYLVSDVLLLADVFENFRKICHKEYNLDPCHYITAPALSWDAMLRYTEIELELLTDVDMVHFLKKGVRGGVAQCSKREAVANNQYVPNYDPQQPESYIMYLDATNLYGAAMCQYLPYGNFKWVTDVENFNCFSVEDDGDKGYVLEVDLEYPAHLHSLHNDLPFCPESMVPPGSKFPKLIPNFNNKTKYIIHYRNLKQCLRYGLVLKRIHRILEFSQSPWLKKYIDLNTSLRNKAKNEFERDLFKLLVNAIFGKTLENVEKRRDIRLCTRWETKTSSLGARVLISKPEFKSCSVFNENLVAIHLGKTKIVYDKPLYVGFTILDLSKTVIYDFYYGYIKKKYGEAANLLYTDTDSLIMEIFTPNFYEDMKRNLEHFDTSNYPTDNIHRIPKTPSILGKMKDEFASVPIQCFYGTGAKAYCIEANTIIKKAKGISKHVTKTQLQKSDYVLLVKKGGVIFRKMYVFVSNLHTIYTELRNKVALSSKDDKRCVINGDVKTLAWGHFLISPHNGTIDDLIRFGNELLHTPELVDLENIPLEELFQVDSFQYDSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5J9</accession>
    <name>A0ABM5K5J9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505463.1">
        <property type="nucleotide sequence ID" value="XM_050649506.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649506.1">
        <property type="protein sequence ID" value="XP_050505463.1"/>
        <property type="gene ID" value="LOC126883831"/>
    </dbReference>
    <dbReference type="GeneID" id="126883831"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="130575" checksum="A7BC91671F2CE345" modified="2025-10-08" version="1">MGMLKVNTTFCGEFIKKAEEVENLERKYFNTKNEVIDVTTDLNYWFEVYVKNIVLTDLSEFEESQSGWALNQIISLEININKFEMAKGASSYIQLHPKVTKKRACINVKNNDQACFAWAIVSALYSVNINTNKTTSYPHYTTVLNLKGLTFPVTLNQISLFEKNNENISVNVFELNVKDELFNFSVLPVRLTKQKREKHVNLLIVQNKYYFNNEVDNVGPWSGGRDEDLIHFHYIWIKDLGKLVKSQLSKHNGKKYICDRCLNYFYTKEKLDAHIIYCEKIDDCKISFTKEPYVKFKNFVYKEKLPFLVYADFESLLVPLRASHSTPSTTSTHPYQRHTAYSAGLYFKCNYDDNFSFYKSHVGLDCMSWFSHEIDNLAQFIHSKLINIQPMNVEVSLKDATERCHICNRKFLEKDRIVRDHCHLTGNFRGFAHNGCNLNYKKAFVVPIAFHNMSGYDSHFIIKDLAKMYDISILPVNKEKYISFTVYHKKTNIRFRFIDTFRFMGSSLDNLVSTLKPENFGILRKQFPNLDDETFKLLTKKGVFFYDYLDKIERLDETKLPNKEKFYNKLNDEHISDSNYAHAKLVWEKFNMKTLWDYSNLYMKTDILLLAVVFETFRDTCFKTYGLDPGHYYTIPGFTWDAMLKYTGCHLETIQDVDMLLFYERGIRGGISQCCNRMGEANNKYMMNYDPSKPSKYLMYLDVNNLYGWAMSEPLPYGGFHWDDTNIDVMSIPDDAKEGYILEVDLSYPENLHDYHKDLPFCVEHCKPPGSKQSKLLSTLYNKTNYVIHYRNLKQAISHGLVLTKIHKVLRFKQMTWLKGYIALNTQLRAQAKTSFEKNLYKLMNNAVFGKTMENQRKHRLVKLVNKWEGRVGARNLIASPKFHSRVIFDQSLMAVELKKAEIIFNKPLYVGMAILELSKTCIYEFHYDYMLQKFPLNQNKLLYIDTDGLIYETECNDIYEEMIKPDIHRFDTSDYPPNNPWNIPLVNKKVPGLMKDENNSKIMTHFVGLRSKQYTYKVAGEKDVKKSKGVKMNVVKMKINFDDYLNCLKSFRETAETKSLFYATQRCIQSKLHEVYSIEQTKIALNPFDDKRHLLSNTFDTLPWGHYSITHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5K6</accession>
    <name>A0ABM5K5K6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505476.1">
        <property type="nucleotide sequence ID" value="XM_050649519.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649519.1">
        <property type="protein sequence ID" value="XP_050505476.1"/>
        <property type="gene ID" value="LOC126883843"/>
    </dbReference>
    <dbReference type="GeneID" id="126883843"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30204" checksum="1E19D4A17024594D" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYIVANLDTAYILEVRDIIVSPPATERYEKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAPRAQISEASNALESTIEKLTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRGRPYPRDRSYSRERNSDICWYHYRFGDQAQKCSPPCKHQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAP0</accession>
    <name>A0ABM5KAP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507255.1">
        <property type="nucleotide sequence ID" value="XM_050651298.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651298.1">
        <property type="protein sequence ID" value="XP_050507255.1"/>
        <property type="gene ID" value="LOC126884940"/>
    </dbReference>
    <dbReference type="GeneID" id="126884940"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1399" mass="160777" checksum="64D880641EE850AE" modified="2025-10-08" version="1">MSDQNKTKRMATKGALTRLTTYFRSIENNEIIDLVDLEMRLFKAEGLLDVFNEVQMLIETDDPDCEENYDTLHAIERQTFEDKYFKIISDIKKLILSRRPTETSDSRSVNGSIAARPTNTSNIKLPPLNLATFDGSFDQFLFFRDSFNSIINDDTSLSNVQKFHYLRLSLRGIAADTIKSLQVCDANYDIAWSLLIERFENKQLLVNNHIKALFNLPLVTKESNQGLRQLLDNTQKHLRALEVLKRPTKHWDDLIIYLSTTKFDNSTRRSWESQNCKDNLPVLDDLLKFLKERCRILESLDNYNDNKQDQNSPRYKGNKSETRAFVSNTENRFKCNFCNKEHKIYYCPDFLKLNPTNRLNNAKRLRLCLNCLGTCHRTKDCRSTGCRKCGKIHHTLLHFENSQSSNSVSTENNSSQSSLPSNVPNTGLQSNESTSTSNFSSTHHISSSVHTAIKPYILLSTAVVNAFDKFGNSHKCRVLLDNGSQSNFISEKFCDILQLSKEKINTSISGINQLTHNINFRTSLTFKSDINNFSKKISCLILPNITSNLPYIHINRSQLNVPTKLLLADQNFEKPGPVDLLIGADTFWDILSVGQIKLGPGLPIIQKTTLGWIISGPIPTNIQHHPQHNCYFSSTSELDSQLTKFWELEECPKTKFVSEEDIYCENHFKQHISRHCDGRFITTLPLKESPSVLGDSLTTAKKRFLNLERKLENNIQLKLEYHDFIREYIKLGHTSLINDTNDNSGFFLPHHCVLKETSTTTKLRVVFDGSAKTTTGYSLNDIMYVGPHLQDNLFYILLRFRQHKFVLGADITKMYRQVFLTPEQRYLQKILWRFNKNDQISAYTLNTVTYGTASAAFLAIRSLHEIAHRHISEYPKISSIILHDFYVDDLLTGCDTSEELREIKETISYLLSSYGFPLRKWTTNDSSLQNHSDPDFLHFGSDEHNKTLGLLWNPSCDSLQFSINISTINLKISKRQILSCTAQIFDPLGLLSPVTVISKIILKELWKLKISWDESVPESIYTLWSKYYFELTKLNTLKIPRHVLSSNPVSVQLHGFSDASEAAYGACIYICCTDTFGNYTSNLYCAKTRVSPMKLVTIPRLELCGASLLSELVEKVTSSVNVSFKNITYWTDSKIVISWINTSPHLLKTFIANRVSQIHKLTNPEFWKYINTYDNPADLLSRGISPSSLSNSHIWFHGPSWLTLPQEEWPQYTKHQEVCITSELPELRNKTLVFHHINNEFTFYYKYSSLNKLTRVFAYVLRFKDNLSIHKHLRITGPLTTIELNNSLLTLIRFVQSQSFPYDYDALSNSNQIDKRSHREIHGNKRANQLIRRASDQIQHFTGKKAISEGNITLTGKTDLIKHGKMYIRQHVPITRRNQLRVARGFLLGMHQTRHICTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAX0</accession>
    <name>A0ABM5KAX0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myrosinase 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507336.1">
        <property type="nucleotide sequence ID" value="XM_050651379.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651379.1">
        <property type="protein sequence ID" value="XP_050507336.1"/>
        <property type="gene ID" value="LOC126884991"/>
    </dbReference>
    <dbReference type="GeneID" id="126884991"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046293322" description="Myrosinase 1-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="100311" checksum="7D9211118ABC1EE7" modified="2025-10-08" version="1">MVRALHILATLLALQLSYGDPQPGYPVHPNFPPKDCEPYPVHYPHPIPEPACEIPVIPPPHYPNIILEPVYEIPVLPVIVGPILDYDDCDYPYPGYPHGPINPGPLPPHLPLPHHLPIPEPCGGLPDWLVAWPNEWPRYFPCGWPNDWPCDFPLGLPNNWPIDFPHGLPHDWPNHFPHGWLPDNLPHGYPNAWPCDWPENWRDYWPDCWPNYWNDCELPIPLPHGHGYPQGPYPGPGPYPGPGPLGPYPGPGPLPLPHNLPYPHPSLPIESCDVIPYSHGSPHGLPHGLPQGWPNQWPRHFPNGWPDNWPCDYPLEFVPEYPHDFPHGLPHDWPNNFPQGWPVPHGYPNEWPCEWPDNWQEYWPDCWPNYWDGCDYPYPAGSVPAIPPPAESCDVFPKEFSFGVASGAYHIEGAWDQDCKSESIWDRWLHTCPSVVLDGSNGDISADAYNHIKGDIELLNNLTVRHYVFSISWPSIIYDGCGEVNPYGIEHYRTLIKLLKLNHIEPIVVLYYGDLPQALQDQGGFLCPSFVEWYTEYARVCFECFGDDVKYWITFHKPTVICKDGYGQGTFAPGINDGPGNYEYICGHNLLKAHAAAYHLYDDYYRPCQNGKISITLNSDWYEPQSCCDTDLCASETKLQFQIGWFAHPIYLGDYPEVMIERIRLNCDYNGYYNARLPVFSHAEIEYIKGTHDFFSLAYDSAFYVTACVDNYWGNICYESDVGVQLVGCEGEYLTCGIRSLLGWISRNYYNPSVFITNDGYASCSRDCYDCDRIEYIKAILRNVRLSMIEDYTRVYGYTYYSYIDGFEWNLVDGRLGGYTLKYGLYDVEFDCPQKTRTARSSAAYYQHLASTGCIDNPCPIPYCYDYNYDYYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD30</accession>
    <name>A0ABM5KD30_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PBZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508097.1">
        <property type="nucleotide sequence ID" value="XM_050652140.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652140.1">
        <property type="protein sequence ID" value="XP_050508097.1"/>
        <property type="gene ID" value="LOC114340352"/>
    </dbReference>
    <dbReference type="GeneID" id="114340352"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="474" mass="53595" checksum="A69A20ADCE2702FA" modified="2025-10-08" version="1">MDKKDKKDQLDKRIVCKYGDKCYQKNPAHHEKYKHPPKRKSPRSPQQALKKIKTDKVEPSKVDSDAEDYNIEDDSNTSSESIPKPTSVKVNHDVSDTDSDDDSESNHSETEDNGNKMEEDSSTQDTNTADSDKEENLIDNNTKNVVGTDNDDSEDTKDKTYSSKEKEWNSIIKDKFLVDMPPDFFQFWDFCEKQAPKSPSEALSKVGIFLVGPYDVLAGKFSKVDKPPEDYLIHWRYYRDPPELQTVLRSDDANGYHIGYFRDAPDKTPVLLVSNAPQKNGILTPMGGNIFAAVNLYLEDLKKSGNPFRKMAVGGIQTALTKEAQRLGIDLSRKTKAIVAREKKIVTRSFNKIGLCVPYNKKSQVGYRELAQTNKELEANLNRLDQAKTKAEQDKCFSDLQPVFTYTSIASDECDFGTGIELGWNIISHGTDRLNATAGRFLASNYRLFNMEAFAKIAEAHMKNRRKGNKLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDT9</accession>
    <name>A0ABM5KDT9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508360.1">
        <property type="nucleotide sequence ID" value="XM_050652403.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652403.1">
        <property type="protein sequence ID" value="XP_050508360.1"/>
        <property type="gene ID" value="LOC114334917"/>
    </dbReference>
    <dbReference type="GeneID" id="114334917"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="171" mass="19791" checksum="73E14062EC82EE56" modified="2025-10-08" version="1">MIENIHIEYFNDKLAAPNATFKFFKYNRTQFAINASIWVLEDLDGRDIEASTKIFVFLSNTFKFFGVELKAPNVCTMWKDDLYGIREIMTKCGDVDLCNIKKGLWQLTNCWPAASIKYFPKSVPQGSYKVTMESKLKDGRVLARIALYGKASLYFKDIQNMNNTSKYNIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEH6</accession>
    <name>A0ABM5KEH6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508594.1">
        <property type="nucleotide sequence ID" value="XM_050652637.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652637.1">
        <property type="protein sequence ID" value="XP_050508594.1"/>
        <property type="gene ID" value="LOC114332318"/>
    </dbReference>
    <dbReference type="GeneID" id="114332318"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="363" mass="42162" checksum="E16631416C86D3E2" modified="2025-10-08" version="1">MEVKQENSEEACKVEIEYNELEGFKCEIQEESNSKSTHDTYFPTNPKIEQLDNTPFEENQNTEKGYLQEENQMEITETLIGHSSNEGSYMSRHSEGTTLNENMKVTTEQGLYKCQICCKQFTTRGYLKVHVGLHTGETPYQCEICFKQFSGAGTLKRHLRVHTGETPYQCEICLKQFNDKGNLKRHVRSHTGETPYQCHICLKQFSNKSNLIIHSRLHSGEKPYKCEICFKQFIQACDLKRHLRLHTGEKPHKCEICLKQFIQAGDLKIHLRMHTGDKPYKCETCLKQFNNGSNLKKHLRSHTGETSHKCEICLKKFIQAGHLRVHLRVHTGEKPYKCEICLKSFNNKSNLKKHLKGHCEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFP6</accession>
    <name>A0ABM5KFP6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509010.1">
        <property type="nucleotide sequence ID" value="XM_050653053.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653053.1">
        <property type="protein sequence ID" value="XP_050509010.1"/>
        <property type="gene ID" value="LOC126886195"/>
    </dbReference>
    <dbReference type="GeneID" id="126886195"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="194" mass="22845" checksum="6F84A21868A2940E" modified="2025-10-08" version="1">MNRSTAPKQSTLVGDEMLENSEDDDDEIGEERFQEEVEKIEKGWQNIQENMLASFLLDDETMNKKKRKGDSLERINDLKRERLEESIKFPNETKQQKINRKLEELNIKLIEIFTNLSEEKGEKVEMDTELKKLLGVIKSTNNKKEDDSIAEKTQQEVKCDHCKLKVEQERQREEQEKIKRALNMGGGKNLHEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL70</accession>
    <name>A0ABM5KL70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Homer family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510945.1">
        <property type="nucleotide sequence ID" value="XM_050654988.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654988.1">
        <property type="protein sequence ID" value="XP_050510945.1"/>
        <property type="gene ID" value="LOC126887447"/>
    </dbReference>
    <dbReference type="GeneID" id="126887447"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01206">
        <property type="entry name" value="EVH1_Homer_Vesl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045027">
        <property type="entry name" value="Homer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044100">
        <property type="entry name" value="Homer_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10918">
        <property type="entry name" value="HOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="WH1" evidence="9">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="220"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="43755" checksum="00365ABF10E9889B" modified="2025-10-08" version="1">MTSGKDTMGEQPIFTCKAHVFHIDPKTKRSWMPASSSAVSVSFFYDSSRSLYRIISVEGQKAVINSTVTHNMTFTKTSQKFGQWSDVRANTVYGLGFSSEAELQKFIDKFNEVKEATRSAISKVTANGGSVVTPVTSANASPISARAATAAADSSTDNLLEPPGNSLMPSANPKPEDDMPHPRSHSISGMQSNESPSHQVKMDKGPYNTSPIDMQLKYENDRLKLALAQSSANAKKWEIELATLKSNNARLTSALQESTANVDEWKRQLASLKEENMRMKAKYQADLENSKGGGDLADELRKEIQSLRIRVEQLESELDSKTNEMKMLSSSNTSTELQKENQELQSTIKLAQSELEIAQSTYESQKHILLTLNQQLASRIHELAAIHDEMTTALQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL81</accession>
    <name>A0ABM5KL81_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510955.1">
        <property type="nucleotide sequence ID" value="XM_050654998.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654998.1">
        <property type="protein sequence ID" value="XP_050510955.1"/>
        <property type="gene ID" value="LOC126887457"/>
    </dbReference>
    <dbReference type="GeneID" id="126887457"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="687" mass="79480" checksum="AE176ED6C26C8EF3" modified="2025-10-08" version="1">MSTSAKNNVVKLFDRPKELVIMPKGNDQTVFDVPSDYIPDQYKSVGNQIVSRFGEEAQGGKIPVNTISIPPLGEILELRRDENFSLFLPKHRKIAGQLINIFIGMRNVDDLLSVAVYTRDRVNPYLFNYALSVALLHRADTQDVDLPSFIRSFPDKYVDSRVFAKAREEANIVPTNSRTPIEIPRDFTASNLEPEHRLAYFREDLGINLHHWHWHLVYPFEAAFDVVNKNRRGELFYYMHQQIVARYNYERLCHGLQRVERFIDWRKAIPEAYFPKLDSLVSSRSWPARVANQKLSNLRRETDQITQDIDDLERWRDRIFDAIHSGNARRPDGTNVALTENEGIDILGNMIESSILSPNREFYGDMHNMGHVFISYIHDPDHRHLESFGVMGDSATAMRDPVFYRWHSYIDDIFQQFKSTLPRYTEAQLSNPGVTVESVSIESGGGANTLNTFWQQSDVDLSRGMDFQPRGAVFVRFTHLNHQEYNYRIVVNNSGAAKEGTCRIFMAPKFDERGNPWLFKDQKNMFIELDRFRVNLRQGQNTIMRASTDSSVTIPFNRTFRDLDTSRPDGGNNLAQFNFCGCGWPQHMLIPMGNTDNPGFRSELFVMISNIDDDRVDQDISGICNDADSFCGVKDRLYPDRRSMGYPFDRQPRENVDTLQQFLTPNMRVQDVVIKFSNRTFRPRQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KM46</accession>
    <name>A0ABM5KM46_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
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            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <dbReference type="RefSeq" id="XP_050511270.1">
        <property type="nucleotide sequence ID" value="XM_050655313.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
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        <location>
            <begin position="176"/>
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        </location>
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        </location>
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            <begin position="288"/>
            <end position="315"/>
        </location>
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        </location>
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            <end position="371"/>
        </location>
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        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
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    </evidence>
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    </evidence>
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    <sequence length="399" mass="46563" checksum="4D4D29D815501554" modified="2025-10-08" version="1">MEFKVEIKEELVEYNQKDLESQLSTSIDLENFKNELELEDNSEMGPKAEIKKEFAAECSQEYRENQLCTSQDLEDLVNKADEDNSGFSRNGMEIVKTELACSTEQQISANTEKTTSKNSNCKCKICFKQFNQAGSLKRHLKTHTTEKLKCKICFKQLATKSNLKIHLRMHTGEKPFKCEICFKQFNQANGLKLHLRVHTGEMPYKCEICFKQFSRVNNLKSHLRVHTGVTPYKCEICFKQFSLAGNLKTHLRVHTGEKPYKCELCFKQFSLEGNLKTHLRVHTGEKPYKCEICFKQFNLATGLKKHSRVHTGEKPYKCELCFKQFSLECNLKTHLRVHTGEKPYKCEICFKRFTLATDLKNHLRVHTGEKPYKCEICFKQFKQRIHLKRHAKVHTGERP</sequence>
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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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            <authorList>
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            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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    </evidence>
    <sequence length="384" mass="44745" checksum="E5811E3D4374A5C9" modified="2025-10-08" version="1">MSSTFSTMINYTLLDVLRRLKRIQAMHEISTDLGPNFRFPRQENKRLGNNSSVFKVTEFPSTDEMINIIKKAQEDALSDAKKIGMEMNRDCCTEINLPTCDNPEEQEEVQGSIIITDTISKEHEPDLEPDFSNEDREFLEYTSTFNNYDSLHLRDYTGQKKAQKSCLSVTLKDKKTRIIKKSTLIWFFQEKQGRLSTDRLLRVKGMTVKNTHKGLSKKKQFRKKPGQGLQPAGNIKKRKMFRQPHERAHKDSTSESRSESDEISLESETLSEDFSDLEDCHNESTKMPVIQLESYYAVFYDTQWYLGRVINSYSSEKFKVKFLQQDLDTFKWPKKDDIQDVHKEFIFYGPVSLSGTEPFSLKRNDLIAIKQKYKTIKSIKSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUH5</accession>
    <name>A0ABM5KUH5_DIAVI</name>
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        <recommendedName>
            <fullName evidence="17">Cytochrome P450 6k1-like</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
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        <property type="component" value="Unplaced"/>
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    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
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    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001971"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57461" checksum="6116BE1E3F79AD5B" modified="2025-10-08" version="1">MSFLNYSWLFSFATFCIGIIFLGYKYVTREFNYWKKRGVYNSKPIPFFGSLYDVATFKLTLFELLKKLYDETEEPYFGMFIFDKPVLVIKSPKLIKDILIKDFNTFCDRTVADVTHHNLISKFIFMQKHQSWKYTRAKMSAVFSSSMIKRYFTNLELINKKFIEHLENMSGPVDAKYIAGHFGTEMIARCFFATDPRCFEREPSRFRQCVHRIFGFSLRNGIVQTLYFFIPSLVKVFKLNPVEDSVMRYLEQTFLEAMDCRKGYSGKPVNMVDVVNDLEKAYNGNFPDRELLISNAIFLLVAGPETTSSIISFALYELALQPDIQERLRNEIKDNCEIYKGFTYEGIQKNKYLDMVVNETLRKYGVLPFIDREPITDYRLEGTDLVIEKGTPVYIPLFALMRDAKYFPDPELFDPERFADTNFNSDGLIFFPFGEGPRACIGKRLAHLAIAACLSHVLLKFSIGKCETTPDPVEFEPKSFTIQSKCGLPITLTPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWB8</accession>
    <name>A0ABM5KWB8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514483.1">
        <property type="nucleotide sequence ID" value="XM_050658526.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658526.1">
        <property type="protein sequence ID" value="XP_050514483.1"/>
        <property type="gene ID" value="LOC126889842"/>
    </dbReference>
    <dbReference type="GeneID" id="126889842"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="160" mass="19125" checksum="895A01935833D936" modified="2025-10-08" version="1">MYQRVMKNQKSVIKKTTMTVIMSLIKPYQQTKTFLFLLHPQRKARNVNGILKTGREILQKKMRSCGEAYQTHSKNKKMRQKRQVRYPCKDCKLKCPSKFTEEEGIQIFLSYWSLGEFQKQREYINKLLVAVVPQYRYIRVGGTRKPRDKNNAYYFVKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWU3</accession>
    <name>A0ABM5KWU3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050514655.1">
        <property type="nucleotide sequence ID" value="XM_050658698.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658698.1">
        <property type="protein sequence ID" value="XP_050514655.1"/>
        <property type="gene ID" value="LOC126889944"/>
    </dbReference>
    <dbReference type="GeneID" id="126889944"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="277" mass="32603" checksum="C7F7F1574FBE244E" modified="2025-10-08" version="1">MRTRKGPKFVKTQRNMAAEQIMQCPLCLETMSPPIIQCKVGHSMCGSCIKESGIKMCPTCREKLTTTRNYQLEQLIEGIKDVLKFDCAYQHKGCKFAVNKQDKENHERECKFRKFTCEGKRFAKWSCNWSGDYSEIYQHFKRDHKDNTRLEFKTDAVMKVSLKTSFNNVYLISLFSGQSYLYCKHRVDTSNKKIYFHFQFIGLKSQAQHYYYEFEVYKGTRKFKITEICTSDTSNIDITFAEEKCFVMSFIAVKNYLNEEGELPFKFRVMSTKKTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX61</accession>
    <name>A0ABM5KX61_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514781.1">
        <property type="nucleotide sequence ID" value="XM_050658824.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658824.1">
        <property type="protein sequence ID" value="XP_050514781.1"/>
        <property type="gene ID" value="LOC126890021"/>
    </dbReference>
    <dbReference type="GeneID" id="126890021"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF8">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="21244" checksum="BFA9F86B8FF53B62" modified="2025-10-08" version="1">MQCYSEISNEKEKIERMQAERKLLELETFEILPKYEIELEYIMYRLDTISREYGLKINAQKTKVMIIDRIRNNQPEIRNVAGFEVVNRFNYLGSLITNNGGCEEEIPRRLTMARSATVKLTKIWKDPAITRNTKLRLVRKLTFPLATYASETWTIKKSDSRHIMAFEMWVYRRIMRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXM6</accession>
    <name>A0ABM5KXM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 6k1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514944.1">
        <property type="nucleotide sequence ID" value="XM_050658987.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658987.1">
        <property type="protein sequence ID" value="XP_050514944.1"/>
        <property type="gene ID" value="LOC126890137"/>
    </dbReference>
    <dbReference type="GeneID" id="126890137"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="546"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1233" mass="142420" checksum="83096161F10A57EE" modified="2025-10-08" version="1">MLLSSWIVDVFAFSLTFSTLLYVYFTRHFSYWKKRNVFYQKPAPFFGNFKDVVTMKTTIGEWLRDEYNKAAKQPYFGIFVFDEPKLVIKSPEIIKNIMIKDFNNFCDRTFASPEYNEVESNFLFMMHNPKWKKHRSQLSPAFTSGKLKGMLPIIHEVGQSLQKYLSDNQTVLEAKEVMAKYSTDVIGKCFLGINPHCFDNDDALFRVLGRAMFDFSIKNALKQTAYFSTPGIVKFFKISFFEQWITDHFIDVFSKSYEAREKSKIRKNDFIDILRDMERKGVIDEDIGSIQGSSMQFFFAGFETTSSTTSFTLYELCLNKTIQNKVRSEIQANIRENKGITYEGVMSMKYLDLCIKETLRKYPVLPFLDRRCINNYTIPGTNLVIEKGASVYIPMFGLHYDETYFPEPMKYMPERFENANYNTNGLVYFPFGEGPRICIGERFGLMSSKLALIYVLTKFEVEKCESTPDPLEFEPKSLFLHSKVGLPMRFKHLVPSPASCYHTKSLSVAAEETRRAECGRAAVAAQQVEEREVLWCNVLLSTAVNHPEESSDDHSSDQEDGKDGFTIQNRRIRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTKANAEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKSEKKNPEKTDKKPPCVYVSKMLLTSSWIVDVLAFSVTLSTLLYVYFTRHFSYWKKRNVFYRKPTPFFGNFKDVASMKTTIGEWLRDEYNKAAKQPYFGIFVFDEPKLVIKSPEIIKHIMIKDFNNFCDRTFASPEHNEVESNFLFMMQNPKWKKHRSQLSPAFTSGKLKGMLPIIHEVGQSLQKYLSDNQRVLEAKEVMAKYSTDVIGKCFLGINPHCFDNEDALFRVLGRAMFDFSIKNALKQTAYFSTPGIVKFFKISFFEQWVTDHFTDVFGKSYEAREKSKIRKNDFIDILRDMEKKGVIDKDIGSIQGSSMQFFAAGFETTSSTTSFTLYELCLNKTIQNKLRSEILANIRENKGITYEGVMSMKYLDQCIKETLRKYPVLPFLDRRCINNYTIPGTDLVIEKGSSVYIPMFGLHYDETYFPEPMKYMPERFENANYNTNGLVYFPFGEGPRICIGERFGLMSSKLALIYVLTKFEVEKCESTPDPLEFEPKSLVLQSKVGVPMRFKHLVPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXT5</accession>
    <name>A0ABM5KXT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514994.1">
        <property type="nucleotide sequence ID" value="XM_050659037.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514995.1">
        <property type="nucleotide sequence ID" value="XM_050659038.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659037.1">
        <property type="protein sequence ID" value="XP_050514994.1"/>
        <property type="gene ID" value="LOC126890182"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659038.1">
        <property type="protein sequence ID" value="XP_050514995.1"/>
        <property type="gene ID" value="LOC126890183"/>
    </dbReference>
    <dbReference type="GeneID" id="126890182"/>
    <dbReference type="GeneID" id="126890183"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF309">
        <property type="entry name" value="PEPTIDASE METALLOPEPTIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028543" description="Peptidase metallopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="84"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="517" mass="59820" checksum="B05EB4D41BB3D09A" modified="2025-10-08" version="1">MEVFLICVLLLRFIAATDAFSEDDAMKFLQRYGYIDNNSIADFNTTLLHFQEQYNLYVDGTLNDETISLMQKPRCQTGENDYSLKGKWYKHNLRWYFPQANHVKGIIQLVERAFKMWEDASNLHFTRVTVPVPKPDITITAVKRKHYFRSNCMGNQKCGIQFDGPGGKLAHSYFPIDNDTCVEIHLDLDEKWSYNLNDTDYDFTNLFMVILHEIGHSLGLLHSNDESAIMYPWYHNKVGNISQDDISGLEALYGRKSTDAYIPTQTSAPTRSTSHISRVHTTRSRPRPNEIIPQQSTKATPHFCVIEYPNILFLAYDPQFKNHHMYIIHEGFVWKNDLNGHMVPNNPEHLSTYLPKQIRNISHVFQNIAGNLIVASNNTMYSVSFPSITISRDIPLFVLPPHAEINVVFQTHTGKTYIWYDNTSFIEYDDLIDLVISRGLIKDIFPGVPTTVKSVFKYIDGHLYFLDGSTYYKYNEFTKKMIEIGRFNWNLFGIPCPDDGLVTQLKYLLNKVGSFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXT6</accession>
    <name>A0ABM5KXT6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515004.1">
        <property type="nucleotide sequence ID" value="XM_050659047.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659047.1">
        <property type="protein sequence ID" value="XP_050515004.1"/>
        <property type="gene ID" value="LOC126890194"/>
    </dbReference>
    <dbReference type="GeneID" id="126890194"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="305" mass="34867" checksum="34392503AF9D5855" modified="2025-10-08" version="1">MLTEVNNLSSRIENISRRKVEYKDTDFGPFLIMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMALNSTEILEKVFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNGKIISARRLNKRVLDSNGTVTYIPTGTVQLLFDVRTPPKEIIIYLNLVTVDPYIPPVQQCFKCLRFGHSQRQCRGKARCPKCSDEHTFQNCTVSVPKCLYCDLEHLATNKICKEFERQKKINEVMVFQDLTFFEAAKLFPQIKEKPENSRMFQRSRDFLSLLSSSPRAFTQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY91</accession>
    <name>A0ABM5KY91_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515147.1">
        <property type="nucleotide sequence ID" value="XM_050659190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659190.1">
        <property type="protein sequence ID" value="XP_050515147.1"/>
        <property type="gene ID" value="LOC126890325"/>
    </dbReference>
    <dbReference type="GeneID" id="126890325"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="63019" checksum="954A66F0E31341F8" modified="2025-10-08" version="1">MPMKASDFRQLYRKRDIIEQRLNNFIKFIESMTNIAINDLSEDHFSQIELNTERTESLFTEFDEIQMSIELNCQDQDIQQEYAKRQRLDTIFSKTFSRARTMLKRKCSDLSSSQSKRLDISHEYSGLEGVKLPPIQLPVFHGDYLKWIEFKDTFEGLIHNNKVLADIQKYHYLRASLKGDALKIIQSLDFSAQNYNSAWQTLCNRFDNSRMLVNNHLKALFEIENLNKESALGLRSMIDSVKKHLFALKSLQLPTEHWDAIMVYLVSGKLDKFSSREWEKRKIDNSLPSLNEFLEFLKNRADFLETIELSNVTKPDYKSNYQDKRSRSLLTSKSRSCNFCKQNHLIYLCEEFLKLSVAQRWDKIKQLNLCRNCLCTGHSYKQCKSFGCKICKAKHSSLLHENKPSDIHVKENSSINFNPNNDSENEPNKVKLSTNTSENNVNRNEIVLKNNCSNNDYVLLSTAKVRVHDRYGNTHIARVILDSGSQSCFITEDFLNLKQGGSWRRLDVKGPPPPAAPGRTRVEQGKHKSKQKQNEKHKRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYM6</accession>
    <name>A0ABM5KYM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515296.1">
        <property type="nucleotide sequence ID" value="XM_050659339.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659339.1">
        <property type="protein sequence ID" value="XP_050515296.1"/>
        <property type="gene ID" value="LOC126890423"/>
    </dbReference>
    <dbReference type="GeneID" id="126890423"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spaetzle" evidence="4">
        <location>
            <begin position="114"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24199" checksum="EA9E5C4B68BE9D73" modified="2025-10-08" version="1">MARFSVSSMFSTSVLMPLLCLVQKGHFLAHFRKGPNSVTRAVSISQSPIYHEQYLECRNQICERADDYPEKEILRIMQDTEHIEGFFGYILNSTTTRATINIHTRFGSGKGERLCQIGYNGTFTPRVLRNVGLQWKYVVNVEGYHQRFTSEICKYPHGSTDPGVTDQHCTTFGYNCKQTFTEVYLLTYEDYLIDFDKFMIPTKCTCDCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0T6</accession>
    <name>A0ABM5L0T6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516052.1">
        <property type="nucleotide sequence ID" value="XM_050660095.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660095.1">
        <property type="protein sequence ID" value="XP_050516052.1"/>
        <property type="gene ID" value="LOC126890926"/>
    </dbReference>
    <dbReference type="GeneID" id="126890926"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="599"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="686" mass="77743" checksum="F755DE723E1CBFDC" modified="2025-10-08" version="1">MDNSKPKQKTLTSFFSASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKAIFRSAYYIAKNDRPYNDHFGLLELQKLNGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVSVKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0W6</accession>
    <name>A0ABM5L0W6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516076.1">
        <property type="nucleotide sequence ID" value="XM_050660119.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660119.1">
        <property type="protein sequence ID" value="XP_050516076.1"/>
        <property type="gene ID" value="LOC126890942"/>
    </dbReference>
    <dbReference type="GeneID" id="126890942"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="380" mass="43150" checksum="0FA0408541C043DC" modified="2025-10-08" version="1">MYVDDFISSFPNVSEAIVTHTQLVNLFQKGGFKLTKWMSNSNDLLSTIPEPLQLVKTKQFDKSVSKVLGLQWEEKCDNFSFGLEIPSSTRCTKRNMLSLVARMFDPLGFLSPITLLLKIWIKKLWTLKVDWDSTVPKEIEIAWEKFQNEFHVLYKIQIPRHIAVTPNSSLSFVGFSDASAAGYAAIVYSRVVNCTGQVKVTLLYSQSKVSPMSKITLPRLELCGALLLSKLLSHAIETYSPRHNIDKIFALSDSMIVLNWIKSSEKNLKIFVQNRVVTIHKMVPSEYWFFVSGKENVVDCASRGLFPSSLVNHSTWFTGPNWLLLEPEYWPIQSVNGQEIMICDSEYRSQTFFGNVTRVTPKTMYAALVTANVVSRPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L136</accession>
    <name>A0ABM5L136_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516146.1">
        <property type="nucleotide sequence ID" value="XM_050660189.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660189.1">
        <property type="protein sequence ID" value="XP_050516146.1"/>
        <property type="gene ID" value="LOC126891009"/>
    </dbReference>
    <dbReference type="GeneID" id="126891009"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="150" mass="16858" checksum="202D2E658FA2326D" modified="2025-10-08" version="1">MADLNKAGPSGVKRRKTVKVRNEKNLSVEELMQFLYNSDSDEDYEDSDVDNFEIENVSEDSSGSDTEGDVLQNELNNTVADNPDVQITDNEWTETTSGMKQIPFTKRSGLLVDSPGDSAYDWFRLLFDDELLNMIVLQTNSYAVEVLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1F8</accession>
    <name>A0ABM5L1F8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516280.1">
        <property type="nucleotide sequence ID" value="XM_050660323.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660323.1">
        <property type="protein sequence ID" value="XP_050516280.1"/>
        <property type="gene ID" value="LOC126891142"/>
    </dbReference>
    <dbReference type="GeneID" id="126891142"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26610" checksum="A8EDEA514F6808C3" modified="2025-10-08" version="1">MKERVRRLSHPDYLQHDLNILRNIFVENSYPPRLINKLICNVPFVNRNILTASTMSQPGPLAQSNSAQTSVYFYALPYIPKLTIELSKIFKEFKNIKIANKNIKTIRQLYSKIKQPLTTLECTDVVYRIECTACPASYIGETGRNLSSRIISHKSDCRLNKPTCALAEHTINLDHKIVFNNAKILARESNKFKRTFLEMVHISKSDDNNLNKRSEIQNLSKIYNYILTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L227</accession>
    <name>A0ABM5L227_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516492.1">
        <property type="nucleotide sequence ID" value="XM_050660535.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660535.1">
        <property type="protein sequence ID" value="XP_050516492.1"/>
        <property type="gene ID" value="LOC126891357"/>
    </dbReference>
    <dbReference type="GeneID" id="126891357"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27633" checksum="6D2ACFE8D98ADAF2" modified="2025-10-08" version="1">MNIKLNINKNENSKPTVSSTDKQVTKRKHPTLSPIISTNNIESFEDFCSDDSVKDPDYEYSNGDANNRRSSSSSSGSNSCSCSSSSSSSSDSEADQACSKAVAPSKIENILRCFSSSSTNEDETPRDCVAEPVAGRFTNNNFSNPSDPVASRSTISADIASPCIEGNENVNSRKERKRKATPNNWLRAKAKILRNSGKSYLSNSKKEMTIVPAKSLKAPCSEKCKQNCVQKITETQRQQIFDNYWTMGARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L401</accession>
    <name>A0ABM5L401_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517172.1">
        <property type="nucleotide sequence ID" value="XM_050661215.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661215.1">
        <property type="protein sequence ID" value="XP_050517172.1"/>
        <property type="gene ID" value="LOC126891878"/>
    </dbReference>
    <dbReference type="GeneID" id="126891878"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="693" mass="81370" checksum="91486570E6153EA8" modified="2025-10-08" version="1">MDVKQQVTEEMREVEIYNNEVDDGFLDSCKTEIHEEPKKEGIHDTFVYSDSQEFPTKIEVDPDPDGSQLRPTEEINEKGYLQDENRTEIREKPIQDSACKGNDTRRQTEEKPLNKNVKVVTGKRTYKCEICFKQFSKASHLKRHLGVHTRETPYKCEICSKRFRLAGNLKGHLRVHTEEKPYKCKICFKQFSRKNVLKHHLRIHTGEKPYKCEICFKQFSQAGVLKGHLMVHTGEKPEKCEICFKQFSRKDSLRNHLGMHAEEKPHKCEICFKQFSQAGTLKTHLRVHTEEKPYKCEICFKQFSRKNVLKQHLRIHTGEKPYKCEICFKQFSQAGGLKGHLMVHTGEKPEKCEICFKQFSRKDSLKNHLRTHAEEKPHKCEICFKQFGQASNLKTHLRVHTGEKPEKCEICFKHFSQASHLKRHLRTHTGEKPHKCEICFKQFSEAFTLKVHLRVHTGENKSEVEKAHKCEICFKQFSQTGTLKTHLRVHTGEKPHKCEICFKLFGQAGDLKVHLRVHTGEKPNKCEICFKQFSKASDLKVHLRVHTGEKPYKCEICCNKFRQAHNLKEHLRLHNGEKPYKCSICFKQFSHKNVLKHHLRIHTGEKPYKCEICFKQFGHPGHFKQHLKIHTGEKPNKCEICFKQFSRGNDLKVHLRVHTGEKPYKCEICFRRFSQACTLKKHVRMHTGEKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4M4</accession>
    <name>A0ABM5L4M4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517392.1">
        <property type="nucleotide sequence ID" value="XM_050661435.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661435.1">
        <property type="protein sequence ID" value="XP_050517392.1"/>
        <property type="gene ID" value="LOC126892017"/>
    </dbReference>
    <dbReference type="GeneID" id="126892017"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="360" mass="41660" checksum="5DBCF2BCB0143E7C" modified="2025-10-08" version="1">MEGNKDEALRCVDLAEKFIQEKNRQKAEKYLNKAEKLFPTDKAKDLLLKINLMAPSNPETTQPRRRVTTQKSEEKENKAPDYTPEQEEAVKRIKKCKDYYEILGVSKDATDSEIKKSYKKLALQMHPDKNKCPGASEAFKAVGNAVAVLTDTEKRKQYDLYGSDEDRLSSHSHHHTYTRGFESDATAEELFNMFFGGGFSGPNVYVRRGGRWQRQTASSQSHQEHSHHREQQSSYTAFIQLLPILLAILLSMASSLFISDPAYSLQVSTKYPILRKTANLNIPYYVKDNFHMEYQGSVKRLEMSVEEDYIQTLKHACYREKSYKESMIWKARNFGDQELYHNAQNIKMPSCENLQNLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4S1</accession>
    <name>A0ABM5L4S1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517437.1">
        <property type="nucleotide sequence ID" value="XM_050661480.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661480.1">
        <property type="protein sequence ID" value="XP_050517437.1"/>
        <property type="gene ID" value="LOC126892049"/>
    </dbReference>
    <dbReference type="GeneID" id="126892049"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="9">
        <location>
            <begin position="44"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="11">
        <location>
            <begin position="243"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="10">
        <location>
            <begin position="406"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="642" mass="72801" checksum="3FC2B95AE6B38D4F" modified="2025-10-08" version="1">MGKGGLLSTEWNIPKATNIKPESHHVTREKRSQILGSTNEKKFRGCTIWFTGLSGAGKTSISFALEERLVSSGVPSYSLDGDNIRYGLNRNLGFSEEDRKENIRRVAEVARLFADAGHICLCSFISPQTADRNIARQIHENNNLPFFEVFVDTPLEICEQRDVKGLYKKARAGKIKGFTGIDQAYEKPENPELVLKTVNASVETAVDIVWELLQKHGILPKLVPDSHLHCNGNENISTAQSVTVPELFVPKNKLQAILAEAKNLPRLDIGVVDLQWLQVLSEGWAYPLKGFMKEDEFLQVLHFNTIELNGDKISQSIPIVLAISSEDKNRLQSHKAIALYYNKEVYAILRDPEIYFHRKEERAARQFGTVEKLHPYIKMIYESGDWLIGGNIQALRRIKWNDGLDEYRLTPNELRKKFQEMKADTVFAFQLRNPVHNGHALLMTDTHRQLRDRGYKKPVLLLNPLGGWTKDDDVPLNIRIQQHKAVLEQNILNKDSTVLAIFPSPMMYAGPTEVQWHAKARLIAGANHYIVGRDPAGVPHPLGKEATPDGNLYDATHGARILKKAPGLGSLEIIPFRVAAYDMTKRKMDFFEPNRKDEFDFISGTKMRRFARTGENPPDGFMAPKAWNIIADYYQSLEMKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4S7</accession>
    <name>A0ABM5L4S7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517442.1">
        <property type="nucleotide sequence ID" value="XM_050661485.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517443.1">
        <property type="nucleotide sequence ID" value="XM_050661486.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661485.1">
        <property type="protein sequence ID" value="XP_050517442.1"/>
        <property type="gene ID" value="LOC126892053"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661486.1">
        <property type="protein sequence ID" value="XP_050517443.1"/>
        <property type="gene ID" value="LOC126892053"/>
    </dbReference>
    <dbReference type="GeneID" id="126892053"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028546" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="68"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="394" mass="42853" checksum="12E2F279F588B658" modified="2025-10-08" version="1">MKVFILITCLVVVSPNWMEMSNGALVRIPLKKVKNEQNILSNLVRSGLHGKLRKTGKVSLTNEQNMGYYGEIGIGTPPQKFNVIFDTGSADLWVPSSQCPKKLDKTNACQSHKQYDASKSSTYRANNTKIHFDYGTGNVDAVLSEDNVEVGGIVVKNQIFGEATIELNIPKGNQDGLLGLGSSELSPKNTPTVIENMVQQGLLDKPVFSFYLSQAATGDKGELVLGGSDPKDYKGDFTYVPISGKPEWQVSAQGISIGNQHVCQNGCETIIDTGTSVILGPWDDVEAINNVIGGKVATCNDPNNTMVYCIDCNTNLNDLPDVVFSFGGQQFAIPASTYIVKNSDLCISSFAKQSILELLLEGTWLVGDTFLRSVYTEFDFGENRIGFAKLAKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6R5</accession>
    <name>A0ABM5L6R5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AT-rich interactive domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518131.1">
        <property type="nucleotide sequence ID" value="XM_050662174.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662174.1">
        <property type="protein sequence ID" value="XP_050518131.1"/>
        <property type="gene ID" value="LOC114332463"/>
    </dbReference>
    <dbReference type="GeneID" id="114332463"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="666"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="868"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1186"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1573"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1723" mass="188611" checksum="888BFA2F66AED950" modified="2025-10-08" version="1">MANFLGKDQATYAKEREVFLRDLQHFHEIRGTPFKRAPTLGGKEVDLYLLYTLVTSQGGWLRINSKNTWSELLPVFKLSASCVNGSIALKQIYLRYLDRWEKVHFLHEDADRTSDDDEESRHKRWSARTLHSVPCNYNYAQHIVADANREHNHLSTNLYKQSDYDRLSLSLISPLPNEQDFAINVCTLLSNDGKHTLKLEKHPRLINQLLGHAGVFNHSSTRQLFTHFYNVIRKKPIHNFWKDVLESQEYLDLTNETKFKAAETEVPSKSEPLIAGQEEEIAAIIDLNISGQSDELSEENADSVDCEIIEENCDSFKLKLTPDDSDLFCLKRSLGTQDYVGQRVLQIATILRNLSFIEENVPILVKNTSFIRFLLLCSISRWNVLSNLGMDMLCNISSEFIIRDLQSDLLATKLLKVVNHGLKSEDRAACLTSLEVLNKLSQNEQNEDVMQRLLQKHVYKHVCSFLTLHDVMLLIYTLECLYSLSSLGEKSCNYIIINHGVIDTLVSLITVEGKSYGPKACIGMKLVETLPSGSAQQTQAPTPVQTPPSSQNQSVSVTSTTVTVVSTSSSMLTSINPINTITPVTTSITTPIVNSSPTPKSAPSTPVRQVPIVPQRLMPINPPPVTTTAAPISSVIHSTSTSMSPLQMIQQQHAHQQAIQENEQFALAWLRATYEPCVAGKVDHQELYRHYLNSCSAIGRKGVISPLHFPRCVRSIFGGTVGPNPMKPTNASDPQYYDGIKVRDKPLIINLPPSSVPQTKIVTIPTPTKTPLVRRKSSVQPVQVAPAQGQANTLTVIADNNLAAEAGMASSPASPILKAQLSAPPKQKDSSPVSNKGDMKSQAMAHPHLSQALLGATAASTSTATTTITVSSGGSSKENQTMSTSTAAGQTSNTSLIKSLLATKVNDCMSTVSMRTATDCQNVAQVAARQQRLLAQQGQHMLDKTSMKESPKNVRLNGVRQLFTDAEIGDPSVSSTTQFTDLTKGKKEPPQPPPPPLAPLSNNLKGGRSQRIDNEDSDSLGNHSLASSSGIGTVGIGGVSSTEDGDNSLTSFEGLLNGVPNLDNPANDDSNSKDSVRNVASEISINKPLRLADLLEKKFEKSPPLLNGTMGKDLRLGDRSMDLVENHIEKALSRDKEPHTEKPQKMEIVEVKDEPLRDMLYQAGLKRSASEEMMEIEAKRPLLVSNVNGSTADSPAPDSSSSNGDDGPSTVSTAAAKLFADIAADILEDEDEEQLLQEAAQPSHPPQIVAEQQMQIQGHNPLQQIIVDNSQQVLLAQQRQIIVSQAQLPTTNQMVFSTGATHLKTQSGQTVIVQNTSGQRPMMLAGQNAGQILLSQGLQGQMQLVASSQPGQYVIQTSSGSGQGAAYVVAPPQNAMVHGGQQQTVLLAQTSQQQGTGAKTIIILQQQPPSGSATQHQKVVVTPQGQQVVVTQVPRPVMHTSSVSNNVSPVTKVIKTMASNNNSTTTISAQQSTHHSSPNVNIIMSDKKEDIKKHKIARDLTTPYICDWADCYVERRFRSANEVYLHACEAHCPLGSEEMICQWDRCDNMKRKRFSLMTHLHDKHCNTEAMKQSLLKRKQAAHSKHVETAPPSSTSPHPGYAPDAALHAIKRHALEFVNPKELQLKSSIPVTSGLTAVVTRGGPQLTSDQVRCRLIDDNEGPVTKSIRLTASLILRNLVIYSSQCKRYLKSYESHLANVALSNVESSRTIAQILFDMNDGSTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8Q2</accession>
    <name>A0ABM5L8Q2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Neutral ceramidase</fullName>
            <ecNumber evidence="2 5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_028128589.2">
        <property type="nucleotide sequence ID" value="XM_028272788.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518818.1">
        <property type="nucleotide sequence ID" value="XM_050662861.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272788.2">
        <property type="protein sequence ID" value="XP_028128589.2"/>
        <property type="gene ID" value="LOC114324889"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662861.1">
        <property type="protein sequence ID" value="XP_050518818.1"/>
        <property type="gene ID" value="LOC114324889"/>
    </dbReference>
    <dbReference type="GeneID" id="114324889"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028554" description="Neutral ceramidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="536"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="707" mass="78012" checksum="4DCE460A6BCC07EB" modified="2025-10-08" version="1">MLSIKILLCMLLAHQSAVEAVYNVGVGRADCTGPSAEITFMGYAKSGQKGCGIHLRQFSRAFVIKDENTLVAFVTIDTCMMNHPLKQAVIDKLDLKYPNVFTLKNTILSGTHSHSTPGGFLKDVMLDIPSSGYCKETFNALVAGIVKSIDKAYNNQVEARIFYSTTTVTNTNRNRSPAAYLYNPESERKKYETDVDKELVQIKFVSTKDNVAIGAINWFPVHPTSMNNTNCLVHSDNVGYASLLLESSVNTDSLPGQGDFVGAFASTNLGDTSPNLKDPICVNTGEPCDFVHSSCAGGNKYCISFGPGEDMFESTKIIANNLFQNGKKLLDGATTDATEITGTIQYIHKFSHMPSQTTTYQLENGTQINVRGCLPAMGYGFAAGTTDGPGEFDFEQATNTSNPFWNVVRDFIFPPTPDDVVCHFPKPILIMSGRITKPYEWQPVTVSNQLVKIGQLVLIAVPGEFTTMSGRRLRDAVRKAIITNDGPSDSLVVIAGLSNVYTSYIATPEEYQLQRYEGASTIYGPYTLPIYENIYGQLTKAMMKNETVNDDSSPYKFPKDMATLITPVIMDSSGWFNNFGDCVVQPNDCYEPGQTVSAVFVAGHPRNDVMQDKTFLTVQKQESQNQDKPTWKTIATDASWETKFIWSRPDPLTPTSQAEIRWEIPDGTQPGSYQIQHFGNYKTLFSGIYAYSGVSRIFSVKENCQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L944</accession>
    <name>A0ABM5L944_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518960.1">
        <property type="nucleotide sequence ID" value="XM_050663003.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663003.1">
        <property type="protein sequence ID" value="XP_050518960.1"/>
        <property type="gene ID" value="LOC126893061"/>
    </dbReference>
    <dbReference type="GeneID" id="126893061"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="406" mass="46901" checksum="5628512C09C4430E" modified="2025-10-08" version="1">MPKRHYIRRQVHQQEPHIFDLYQKPRFDDTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFAIHDTLLEIKGSIKKAGNGTVSLAPNAGSFLFDTCTYIQSSHDMEIVRDPGVVSTIRSLLCYTPEDSKFLSTAGWNYPNYPHLTGDAFSLLIPIKHIFNIFNDYTKLTYGRQMFRFVRARNDKDCIVVQEPTASTTVTTVSLTIASMELKVKHVFPNDDVKIELMTPIKNNTPITIPFRKWELNELPSLTAGSRREIWSVKTTSAVERPRYVIVAFQTSKRDDIHANPTLFDHIRMSSVRVVINGDYWPNERMQLDFTKNDYAIAHYNYTELFPSYARSLTKHPILDYSAFKRYALFVFDCSKQDDTSFRSGTVDVKLEIEADEGFPAGTRAYCLIVHDSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L994</accession>
    <name>A0ABM5L994_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519012.1">
        <property type="nucleotide sequence ID" value="XM_050663055.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663055.1">
        <property type="protein sequence ID" value="XP_050519012.1"/>
        <property type="gene ID" value="LOC126893109"/>
    </dbReference>
    <dbReference type="GeneID" id="126893109"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="73543" checksum="1A43CD90C54B6545" modified="2025-10-08" version="1">MPLTREQQLEIRSAADVSIKQLCQDQTFIKSIVDSVSAGIVQILNSKLDVYEKKIDDLKTEITKIKTDHEVEIQTIKASLIDLNKKGDSFDMIKITTELNQIKRKESNILIFGVPETEIHLQAYIENMFTAISMNRNPQLNGLHVSRLGLQPSANSNKCRPIKVTFPNSNQVTNFLKLNPKLKSLDCYKNIYMRSDQTVMQREYTSKIKKELSDRLAAESWLRDGVRSSELFPEDTYTVYRKDRSFGKFGGGVIFAVNNNVCHSEQHSVVFPIEKIDVLCVKVFKTNIKPIFFITVYIPPNVTFSEYSDFFDYIETFHETHEVVLIGDFNLTDLAAYYVNNSQITPLINRFVQLLNYTDSVQCNKIKNIHGKILDLIVTPSVFSCEVTPEVNALVPIDYHHPALTCYFPYEVKEDEYFVPNQKRLNFRKYNVNKFNKLLTEMDWSHLKHFSDVDSAVDSFSLSLQEIIDKCVPLSSTRSQKYPAWFTSEIIAKVKRKHHYLRMYRRSKYCFYLQRAKDLRRTIKLEIQLEYKKFIERSQNSFKSDARQFWNFVNAKNNKSRIPGLMKYGSDKFTTSQDIVNAFANFFKSVYISDSNSSPSVTSYFNYNPSSYFNIGSSSMQATKAKISAWNTVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9A0</accession>
    <name>A0ABM5L9A0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519021.1">
        <property type="nucleotide sequence ID" value="XM_050663064.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663064.1">
        <property type="protein sequence ID" value="XP_050519021.1"/>
        <property type="gene ID" value="LOC126893118"/>
    </dbReference>
    <dbReference type="GeneID" id="126893118"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="355" mass="40113" checksum="8A4A469EEBECF39B" modified="2025-10-08" version="1">MLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9C8</accession>
    <name>A0ABM5L9C8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519039.1">
        <property type="nucleotide sequence ID" value="XM_050663082.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663082.1">
        <property type="protein sequence ID" value="XP_050519039.1"/>
        <property type="gene ID" value="LOC126893133"/>
    </dbReference>
    <dbReference type="GeneID" id="126893133"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1250" mass="145164" checksum="3C3CA76618CF9E40" modified="2025-10-08" version="1">MNTCSRCDKSYSRSDNLSRHIKKCKYGNVDSDKNGDYYIPKKRLRPLGVEVIDGTVSKLSHAFKNRIASYRFSSDKKLDYHGFLNDVKPKVLNILSEYLHQHNSIKVNFEIFGIYLKPDTNLSDIKSMNTCNKIITISTELDEVFDDFKEELMTQASEFQEKDSNWVLQEIMFLDVNINKFSSISASTYIRLPIPIVRKHAILNIENKDNKCFAWSIIAAIFPASGNPTKPESYPPYDTLLNFEGIDFPMKLKDIKKFENLNNISVNVYGLESNFVNNKRQYEIVGPLHFTSNRHATHVNLLLITNDKQSHYCLILDMSRLVRSQKTKDRHKVYLCDGCLQFFVCEEKLDNHQNNDCSHIYTELPTTKPKINKFGEMVPENILKFINIQKMLPVPFVIYADFESLLKPIDHVEPFNGNSYSVKTAEHQAYSFAFYLKCNYDDSLSKLIKYEGQDAPKVFIQKLDDLVHELYNNHLKHIKPMSPLTKEEIEKHETATECYLCGKPFNPFNRKVKDHHHLNSLYLGPSHNSCNINNKLSNTIPVFFHNMSNYDCHLFIKELSTTGEKVSVIAQTKEKYITISKRILVEESKNGLDKYITLKFVDSYRFLAKSLDILSTTLNSEQCTEIRKYFPNTKHFELVRHKGVFPYSYMDGFDRLKEKTLPPKENFYNNLTNKHISDEDYARAIDVWNTFDCKSMSDYAMVYLVSDVLLLADVFENFRKICHKEYNLDPCHYITAPALSWDAMLRYTEIELELLTDVDMVHFLKKGVRGGVAQCSKREAVANNQYVPNYDPQQPKSYIMYLDATNLYGAAMCQYLPYGNFKWVTDVENFNCFVVEDDADKGYVLEVDLEYPAHLHSLHNDLPFCPESMVPPGSKCPKLIPNFNNKTKYIIHYRNLKQCLRYGLVLKRIHRILEFSQSPWLKKYIDLNTSLRNKAKNEFERDLFKLLVNAIFGKTLENVEKRRDIRLCTRWETKTNSLGARVLISKPEFKSCSVFNENLAAIHLGKTKIVYDKPLYVGFTILDLSKTVIYDFYYGYIKKKYGEAANLLYTDTDSLIMEIYTPNFYEDMKRNLEHFDTSNYPTDNIHRIPKTPSILGKMKDEFASVPIKCFYGTGAKAYCIEANKIIKKAKGISKHVTKTQLQKSDYVLLVKKGGVIFRKMYVFVSNLHTIYTELRNKVALSSKDDKRCVINGDVKTLAWGHFLISPHNGTIDDLIRYGNELLHTPELVDLEKIPLEELFQVDSFQYDSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZJ9</accession>
    <name>A0A6P7EZJ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114324788</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the NELF complex, which is at least composed of TH1/NELF-D and NELF-E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128436.1">
        <property type="nucleotide sequence ID" value="XM_028272635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZJ9"/>
    <dbReference type="FunCoup" id="A0A6P7EZJ9">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272635.2">
        <property type="protein sequence ID" value="XP_028128436.1"/>
        <property type="gene ID" value="LOC114324788"/>
    </dbReference>
    <dbReference type="GeneID" id="114324788"/>
    <dbReference type="KEGG" id="dvv:114324788"/>
    <dbReference type="CTD" id="38982"/>
    <dbReference type="InParanoid" id="A0A6P7EZJ9"/>
    <dbReference type="OrthoDB" id="378874at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12305">
        <property type="entry name" value="RRM_NELFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000448">
        <property type="entry name" value="Negative elongation factor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034637">
        <property type="entry name" value="NELFE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028128436.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30898" checksum="EC0897554EB40EDB" modified="2020-12-02" version="1">MVYIHFPANFTEEELMLQAKYQKLKKKKKAIQALKAPKPEPEKPIIPKRPAEARDAREVAKKLIKSGVIPAISKQQKQPEQGFKRPRGLERKLISDKTVSGYQPFSAVQMEDGPDNPQNTPPRIKNLYDTFANARDREERGLTEKQQQQVKTDKPRQGNTIYVAGYKITEEFLKKHFTTMGNIINISMEIEKNRGFITFDKTDAAERAISEMDGSMVSGIPLKVSLARRQPQIEPINDATSSAAWATLASSHSQKGNHRDKRNLVSYDDMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F182</accession>
    <name>A0A6P7F182_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114324152</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028127698.1">
        <property type="nucleotide sequence ID" value="XM_028271897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F182"/>
    <dbReference type="FunCoup" id="A0A6P7F182">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271897.2">
        <property type="protein sequence ID" value="XP_028127698.1"/>
        <property type="gene ID" value="LOC114324152"/>
    </dbReference>
    <dbReference type="GeneID" id="114324152"/>
    <dbReference type="KEGG" id="dvv:114324152"/>
    <dbReference type="CTD" id="203"/>
    <dbReference type="InParanoid" id="A0A6P7F182"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028127698.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24492" checksum="06ECC23128E897A9" modified="2020-12-02" version="1">MIFFKSHSAYFSIFYFFICGLQFLFQAPIPALNVPIVWILGGPGSGKGTQCDKIVEKYGFTHLSSGDLLRAETESGSERGKELSAIMERGELVPMQIVLELIRNAIVKALPTSKGFLIDGYPRERDQGVLFEENVAPVNMIIFFEASEQTLTDRLLGRAKTSGRVDDNLETIKKRLNTFNTYTNAILEHYATKLIKINAERTTDEIFAEVTSVLDTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5G9</accession>
    <name>A0A6P7F5G9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin-related protein 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Monothiol glutaredoxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114324971</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128705.1">
        <property type="nucleotide sequence ID" value="XM_028272904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5G9"/>
    <dbReference type="FunCoup" id="A0A6P7F5G9">
        <property type="interactions" value="1373"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272904.2">
        <property type="protein sequence ID" value="XP_028128705.1"/>
        <property type="gene ID" value="LOC114324971"/>
    </dbReference>
    <dbReference type="GeneID" id="114324971"/>
    <dbReference type="KEGG" id="dvv:114324971"/>
    <dbReference type="InParanoid" id="A0A6P7F5G9"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028128705.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15806" checksum="E33B9A2541B8BA06" modified="2020-12-02" version="1">MNFINRTISIRPNLKLISRFYCAKAKDEIDKLVKNNKVVVFMKGVPEQPQCGFSNAVVQILRMHGVTYDAHNVLVDSDLRQGIKDYSNWPTIPQIFINGEFVGGCDIMLQMHQSGDLIEELKKAGIKSVLLDKPKEESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F639</accession>
    <name>A0A6P7F639_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114325377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114325377</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129238.1">
        <property type="nucleotide sequence ID" value="XM_028273437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F639"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273437.2">
        <property type="protein sequence ID" value="XP_028129238.1"/>
        <property type="gene ID" value="LOC114325377"/>
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    <dbReference type="GeneID" id="114325377"/>
    <dbReference type="KEGG" id="dvv:114325377"/>
    <dbReference type="InParanoid" id="A0A6P7F639"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin filament polymerization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AGAP000499-PA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052630">
        <property type="entry name" value="TTC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091">
        <property type="entry name" value="TTC17 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028129238.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42391" checksum="8A468BD3853B767D" modified="2020-12-02" version="1">MMCLDFQNVKVFLWILIFKVILIQSKTSLWKLNIDKTKIIKVTKFPSIISYSDNQPIFHSGDPLFDIILSTEHYGETWVKQPIQYYCSDCKNRRNGTNPNSYQKYQTADEVLDCGKPVNFTYFDNLVGVVNRNKHPTVPEPQAILCFTKNYGNYKSEMEEFDIDALEKRLKKAKKEKPRSIQLYNQIGNFWRIKGDANKAIECFRRALAVSPHNAEVLLNLARILFSLQYLDDAIYLTRRSLEVQPPDKGAWQQYFTLGEIFKAYGHYQEASIHLRHTLELNPDFEPAQIALKEMETMPAATIHIYTLVIIVCLVLGVLLVILSSVDNIVDFTEEMKPQRHFNKAMAMRSLRGITLTAKRIKRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7L7</accession>
    <name>A0A6P7F7L7_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114325752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325752</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129688.1">
        <property type="nucleotide sequence ID" value="XM_028273887.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_028273887.2">
        <property type="protein sequence ID" value="XP_028129688.1"/>
        <property type="gene ID" value="LOC114325752"/>
    </dbReference>
    <dbReference type="GeneID" id="114325752"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="MBF2"/>
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    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028234352" evidence="1">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129688.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14827" checksum="B8D5C7512FCFE90F" modified="2020-12-02" version="1">MFSTIFKLLFLVTTLILVDISPSRADNYNKCPETSHLRSLIYQNTLKGRVIHVRIPGTGFFEAPITCLQVTDINESFSTPVVEEGGYGREYVVLRIDPVESGEQLEYDVQIYIDEDTRTTAWRKTRHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F807</accession>
    <name>A0A6P7F807_DIAVI</name>
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        <submittedName>
            <fullName evidence="9">Mpv17-like protein isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">LOC114327485</name>
    </gene>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028276123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F807"/>
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        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276123.2">
        <property type="protein sequence ID" value="XP_028131924.1"/>
        <property type="gene ID" value="LOC114327485"/>
    </dbReference>
    <dbReference type="GeneID" id="114327485"/>
    <dbReference type="KEGG" id="dvv:114327485"/>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mpv17_PMP22"/>
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        <property type="entry name" value="IP10007P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028131924.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22043" checksum="5C1E8B23A9D2EB87" modified="2020-12-02" version="1">MTVFSRFVAFTNKHPVIRGMLSYGTIWPTSCIIQQTIAGKTWENYDWLHALRFSIYGGLFTAPTLYGWIRISTIVWPKSTLKSSITKAVTEQFTYGPLALICFFFGMSLLEGKSIEDAKQQVKDKFFPTWKVGVCVWPVLQTVNFCYIPEKNRVPFVSACSLLWCCFLAYMHELQLKQKELEISQVQLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8F7</accession>
    <name>A0A6P7F8F7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein YIPF7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114327612</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132084.1">
        <property type="nucleotide sequence ID" value="XM_028276283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8F7"/>
    <dbReference type="FunCoup" id="A0A6P7F8F7">
        <property type="interactions" value="2143"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276283.2">
        <property type="protein sequence ID" value="XP_028132084.1"/>
        <property type="gene ID" value="LOC114327612"/>
    </dbReference>
    <dbReference type="GeneID" id="114327612"/>
    <dbReference type="KEGG" id="dvv:114327612"/>
    <dbReference type="CTD" id="34696"/>
    <dbReference type="InParanoid" id="A0A6P7F8F7"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028132084.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27710" checksum="E3C7E1A9EA735406" modified="2020-12-02" version="1">MGDYINSNQQDYYWSQQNPPNNQGYYEQDYTQFQNQTLEFNTNIEYNDQAFSNTPQMLIPEQYDNIGKGEDEFDEPPLLEELEIYPDRILEKILAVLNPLRGHSLADDAEYLTKDSDVVGPILFCLLLAANLFLAGKSGYIYGISMISCILMYALLSLMSPDNGTFSLSIVGSILGYCLIPIVALSSLGIFFRLNGPTGLFLAILTIAWSSLSASRLFIAVSGDKEQQPLIAYPCMLVYGVITLLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG26</accession>
    <name>A0A6P7FG26_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exopolyphosphatase PRUNE1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114327682</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPase class C family. Prune subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132168.1">
        <property type="nucleotide sequence ID" value="XM_028276367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG26"/>
    <dbReference type="FunCoup" id="A0A6P7FG26">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276367.2">
        <property type="protein sequence ID" value="XP_028132168.1"/>
        <property type="gene ID" value="LOC114327682"/>
    </dbReference>
    <dbReference type="GeneID" id="114327682"/>
    <dbReference type="KEGG" id="dvv:114327682"/>
    <dbReference type="InParanoid" id="A0A6P7FG26"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="2">
        <location>
            <begin position="228"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028132168.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42692" checksum="3664F537BD5BAE61" modified="2020-12-02" version="1">MESFIEYLQFVKKSLENLDSFGEIHIVLGNESCDIDSSVSATALAYLLHISRPKHISKEALVVAVQNVPAENFLFRTDNCFLYREIQLPLDYLVCRDQIDFDYLVKSKKVTTTLVDHHVVPKNYKILEKTVVQIYDHRPIDAAFDLDTKEVEINIEGVGSCATLIANAIFSGCEDVLFKELGYLLYATILFDTQGLSPDTKRAKELDFQIVEKLEHKFNFTEDRIAVYDRIWNAHNDISTLNPKQILVKDLKMVEHIPVPGLPMLVEDFLKIQGSYEAVRKFAEERDTPLLILVGIDCLNGIRRDVALFSRNEDDPIRNRVLNLLCNCQHKGYDFEFKEVDVSCESVKCFRQGNLTLSRKQIIPVIIDALKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNG9</accession>
    <name>A0A6P7FNG9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114332159 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114332159 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114332159</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137695.1">
        <property type="nucleotide sequence ID" value="XM_028281894.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028137696.1">
        <property type="nucleotide sequence ID" value="XM_028281895.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498320.1">
        <property type="nucleotide sequence ID" value="XM_050642363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642363.1">
        <property type="protein sequence ID" value="XP_050498320.1"/>
        <property type="gene ID" value="LOC114332159"/>
    </dbReference>
    <dbReference type="GeneID" id="114332159"/>
    <dbReference type="KEGG" id="dvv:114332159"/>
    <dbReference type="OrthoDB" id="6776127at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028137695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028137696.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19042" checksum="9E1D1F8D0D0D3242" modified="2020-12-02" version="1">MILSPRGYNVPTTVINESSKIASPLAEKQYGQYFHLAVDFENKENQKSPTIDETTGTEDAIGPTFTNNDVTIRREREKDSSSSSSSISIQSLITPRATQIILPVAVHHPLMILQSKRRLPSSRDVTLKQAYKKKVGISEKKKADLLSLLEKKKNVAVMPQYYRDFYANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRF0</accession>
    <name>A0A6P7FRF0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Myosuppressin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114333191</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138845.1">
        <property type="nucleotide sequence ID" value="XM_028283044.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138846.1">
        <property type="nucleotide sequence ID" value="XM_028283045.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519505.1">
        <property type="nucleotide sequence ID" value="XM_050663548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663548.1">
        <property type="protein sequence ID" value="XP_050519505.1"/>
        <property type="gene ID" value="LOC114333191"/>
    </dbReference>
    <dbReference type="GeneID" id="114333191"/>
    <dbReference type="KEGG" id="dvv:114333191"/>
    <dbReference type="CTD" id="44324"/>
    <dbReference type="OrthoDB" id="6355109at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650958" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028138846.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10095" checksum="2EE5ECDAA2E151BB" modified="2020-12-02" version="1">MQPSTIVVFLFATVLGVLSVTRASIISCPPSPIQEQLNPAVRQLCVAIEQAVEEVPKEYAERLDDRAINLNTKRQDVDHVFLRFGKRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FS94</accession>
    <name>A0A6P7FS94_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114330522</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135670.1">
        <property type="nucleotide sequence ID" value="XM_028279869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FS94"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279869.2">
        <property type="protein sequence ID" value="XP_028135670.1"/>
        <property type="gene ID" value="LOC114330522"/>
    </dbReference>
    <dbReference type="GeneID" id="114330522"/>
    <dbReference type="KEGG" id="dvv:114330522"/>
    <dbReference type="InParanoid" id="A0A6P7FS94"/>
    <dbReference type="OrthoDB" id="10481148at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028219203" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135670.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15773" checksum="D2136A1E7BABBB3C" modified="2020-12-02" version="1">MMNKTAVFVILVLLSVSCVKSDDNINRFRDLTRQPRILNDLLLNVQNLVSNVLNVGCTITEFFINIITSVQRFIVDKIIVALLNSIRGVLFEALAPLMDLIINIVNAIDAAIGAIFQGISNLSCGTTNGIASLINSVLRFIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUA0</accession>
    <name>A0A6P7FUA0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">GTP-binding protein Rheb homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114334075</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139891.1">
        <property type="nucleotide sequence ID" value="XM_028284090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUA0"/>
    <dbReference type="FunCoup" id="A0A6P7FUA0">
        <property type="interactions" value="1565"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284090.2">
        <property type="protein sequence ID" value="XP_028139891.1"/>
        <property type="gene ID" value="LOC114334075"/>
    </dbReference>
    <dbReference type="GeneID" id="114334075"/>
    <dbReference type="KEGG" id="dvv:114334075"/>
    <dbReference type="CTD" id="6009"/>
    <dbReference type="InParanoid" id="A0A6P7FUA0"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028139891.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20524" checksum="AE92D181CCD18A28" modified="2020-12-02" version="1">MPSKQRKIAVMGYRSVGKSSLSIQFVEGQFVDSYDPTIENTFTKSTRINSQDYELKLVDTAGQDEYSIFPSQYSIDVHGYVLVYSITSMKSFDVVKSIYEKLLDITGKEHVPVVLVGNKTDLHLERAIPSDEGRRLAEEWRATFLETSAKQNASVSDIFHVLLMEIEKADGNINEKSNCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FV58</accession>
    <name>A0A6P7FV58_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BLOC-1-related complex subunit 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114331296</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136620.1">
        <property type="nucleotide sequence ID" value="XM_028280819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FV58"/>
    <dbReference type="FunCoup" id="A0A6P7FV58">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280819.2">
        <property type="protein sequence ID" value="XP_028136620.1"/>
        <property type="gene ID" value="LOC114331296"/>
    </dbReference>
    <dbReference type="GeneID" id="114331296"/>
    <dbReference type="KEGG" id="dvv:114331296"/>
    <dbReference type="InParanoid" id="A0A6P7FV58"/>
    <dbReference type="OrthoDB" id="10044187at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146:SF0">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146">
        <property type="entry name" value="MEF2B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028136620.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18243" checksum="E7AAAEDF63950157" modified="2020-12-02" version="1">MAFNADTDLETKVRKSTERISENMHIVANEPSLAFYRLQEHVRKALNPMVERRVDVEKLHTELQGRCYDIEYAVGAIKAMGNSEDSFKNIQDNLKNGIFLKQQLKYEESRRKKSDTSSVYKRLSAHITLDLPELPELSDVVRETANRVEHMMSKATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXV2</accession>
    <name>A0A6P7FXV2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton-coupled folate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114331904</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137395.1">
        <property type="nucleotide sequence ID" value="XM_028281594.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512538.1">
        <property type="nucleotide sequence ID" value="XM_050656581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512539.1">
        <property type="nucleotide sequence ID" value="XM_050656582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXV2"/>
    <dbReference type="FunCoup" id="A0A6P7FXV2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656581.1">
        <property type="protein sequence ID" value="XP_050512538.1"/>
        <property type="gene ID" value="LOC114331904"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656582.1">
        <property type="protein sequence ID" value="XP_050512539.1"/>
        <property type="gene ID" value="LOC114331904"/>
    </dbReference>
    <dbReference type="GeneID" id="114331904"/>
    <dbReference type="KEGG" id="dvv:114331904"/>
    <dbReference type="InParanoid" id="A0A6P7FXV2"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17386">
        <property type="entry name" value="MFS_SLC46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028137395.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67202" checksum="CCAAC9D642E6FDBD" modified="2020-12-02" version="1">MSEAQEAKKMAEKKASKEMEANSQPVNIDGMTWRDRYNFFVENITVEPMLACYVVPSVLASLATQNLNLEKACRVNLRYPSEVCDALTARRTENYAVEEREVQQLVANMGVWKTMLQSALPAFLIMFIGSWSDRWGKRKPCMLFPIVGEFMTVVGLMICTYFFYELPMEVSGLIEGFFPAITGGWFTMFMGIFSYIGDVTTLDVRTLRIGIVNVFCSLGIPIGLALSGILYKKIGFYGVFSVSAIMYIIAFYYGYKSIKEPKKLDKPTLPDQPCAFIRDFFNVRHLLDTFRVAFKKGESKRKKKVMLLMLVVMVVIGPMHGEMSVGYLFTRYRFNWDEVDFSIFSTYSMVTNLIGTSFSVGVFSHVLKFDDAIIGIYSSLSKILSSFVYGFATTSLVFYLGSLVEILNGTSFIAMRSIASKLVPTDELGKVNSLFGVCEALMPLLYGPMYNATYSATIHFMPGAFYILGGILTVPAVIIFAWMYLQSRRESKENTKVHMEKRTSVVADVILNAGTKETQMNIPITTPMLNGIRKSPSQEDTQIKEMQNGIVNQAFEDIGTDVSTGEDTIQKPSQNTIVVNEKVDKKGLNNSAYIHDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXY0</accession>
    <name>A0A6P7FXY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">PR domain zinc finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Beta-interferon gene positive regulatory domain I-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">PR domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC114332141</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="28">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11. Interacts with multiple nuclear sumoylation E3 ligases, including CBX4, PIAS1, PIAS2, PIAS3, PIAS4, PML and RNF4, but not RANBP2. Interacts with LDB1, SMARCD3 and SMARCC1. Interacts with EEIG1; following TNFSF11/RANKL stimulation in bone marrow-derived macrophages, the interaction promotes the binding of PRDM1/BLIMP1 to the gene promoter of IRF8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137678.1">
        <property type="nucleotide sequence ID" value="XM_028281877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXY0"/>
    <dbReference type="FunCoup" id="A0A6P7FXY0">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281877.2">
        <property type="protein sequence ID" value="XP_028137678.1"/>
        <property type="gene ID" value="LOC114332141"/>
    </dbReference>
    <dbReference type="GeneID" id="114332141"/>
    <dbReference type="KEGG" id="dvv:114332141"/>
    <dbReference type="CTD" id="38638"/>
    <dbReference type="InParanoid" id="A0A6P7FXY0"/>
    <dbReference type="OrthoDB" id="7327383at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19187">
        <property type="entry name" value="PR-SET_PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000748">
        <property type="entry name" value="PR domain zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000833">
        <property type="entry name" value="PR domain zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000019">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000132">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000211">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000262">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016608">
        <property type="entry name" value="PRDM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044413">
        <property type="entry name" value="PRDM1_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF59">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013212">
        <property type="entry name" value="PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="25">
        <location>
            <begin position="78"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="24">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="230"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="422"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="809"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_028137678.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="97458" checksum="13629DFCC28B2C26" modified="2020-12-02" version="1">MIFYVHSGLKCLEEPRVSSSGSNMREQEMMEEPAVSSASEFDLANIREEEFELHTTYIVPDLPVDPGTPNRAEATLPRNLVLKSSQVVANAQGVWSTGYIPRGTRFGPLVGEIYAKDAVPSSTNRNYLWRVQVGEGFYRFNGRDNKLYKDNELYYYIDGFDTSKANWMRYVNPAYSGESQNLIACQYKMNIYFYTIKPILPNQELLVWYCKEFAERLNYPLSGEQMLRRLRQQAQQASEITVSTTEPPPSKEPPYEHQLTPTEGSVRSDEGYHSNEYHDDAFTPPEDSSDSDSENNYVLDFSKKTPKETTVIKPVSPENQKNEYRKVKIKITKAYHYKSVKSESEPDVEKDLTMDAAVPEVTTLTPRIITPPTTVIVMDSPPQEVPNKPYYETEVKNTNVISRYSPPSSSILENILLRNRIDTNNNDNHHRQSNATPPPSSPTEMAYSYKKSHRYSTLPCSPDSSSNVQVQNMMPPSPATLKAEVQNSTYVPHPTDNYHSPIQSTNYYSVYPSPNGIVHSTITSSPTHTYSPPITSNFSNNHHNNGTNLIVPTSHIVSSNLTHHLLTPLPALQINGRMSPGCKSPDGKYDLNLCSSSPTSPNGGPSRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGERPHECGICKKRFSSTSNLKTHLRLHSGQKPYACDFCPAKFTQFVHLKLHKRLHTNERPYICQECGKNYISASGLRTHWKTTSCRPNNIDEELNGDGSSNGYYDFAGSDAGLGPIELKDGSEDTKEPYEIHTSQPQVSHTVLHPGLSRPLPSLIQNGAHQRAPPNSIHTGKETRPSVIESSQPHIIECT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZF3</accession>
    <name>A0A6P7FZF3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">JNK1/MAPK8-associated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334320</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140157.1">
        <property type="nucleotide sequence ID" value="XM_028284356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZF3"/>
    <dbReference type="FunCoup" id="A0A6P7FZF3">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644321.1">
        <property type="protein sequence ID" value="XP_050500278.1"/>
        <property type="gene ID" value="LOC126880454"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FZF3"/>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140157.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34932" checksum="33D5B9DF6F3B5EC7" modified="2020-12-02" version="1">MISILNNMSCPGLYCGRTQLSNYELSECGPCPRGFRRNETTYICELCTDEPFFYDWLYLGFVVLLMLVLHCFFIDMISMRRSFNKDILILHSVACIEVAVAAVISLILSHPIGKLTIHSCKVRSIADWYTLLHNPIPNYEKKVYCTQEAVYPLYTTVFLFYGLCLIFMILFRPWLCKKYLPRQSKMSIYAALYFIPILVLMHALVGGLLYYCFPHLVLVLSVISCAAHFAVKLDQSIKSLIVSTLVEPRNLVILIGHWCLHAYGLISITQMLNPSLHASLILLIPLPALFYILTARFTDPSKFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAQ8</accession>
    <name>A0A6P7GAQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">furin</fullName>
            <ecNumber evidence="15">3.4.21.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114335453</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.</text>
            <dbReference type="EC" id="3.4.21.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.75" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028141505.1">
        <property type="nucleotide sequence ID" value="XM_028285704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAQ8"/>
    <dbReference type="FunCoup" id="A0A6P7GAQ8">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285704.2">
        <property type="protein sequence ID" value="XP_028141505.1"/>
        <property type="gene ID" value="LOC114335453"/>
    </dbReference>
    <dbReference type="GeneID" id="114335453"/>
    <dbReference type="InParanoid" id="A0A6P7GAQ8"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000055">
        <property type="entry name" value="Furin-like protease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000072">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF23">
        <property type="entry name" value="FURIN-LIKE PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 17 18" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17 18" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="979"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="21">
        <location>
            <begin position="318"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1035"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028141505.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115743" checksum="857FF815ADBB243C" modified="2020-12-02" version="1">MNLAPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPLASTDINGNDDDPMPQDNGDNKHGTRCAGEVAAVAYNQFCGIGVAYNASIGGVRMLDGVVNDAVEARALGLNPEHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRKGKGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDARLRPDHICTVEHTGTSASAPLAAGICALALEANPTLTWRDMQYLVVLTSRAPPLEKEAGWIVNGVGRKASHKFGYGLMDAGALVTLAEKWTTVPPQHICKSQEIVEDRPINPAYGSSLNFNMEVDACSGTLNDVRFLEHVQCKISLRFFPRGNLRILLTSPMGTTSTLLFERPRDVVSSNFDDWPFLSVHFWGEKAEGKWRLQIINSGNRHVNQPGVLKKWQLIFYGTSVNPVRLRPPNGARSTPWKSPLNTFTFPTQAQPVNPVTDNFFEDNIFKNFQDFPNIYSFSGSDPEEAISSLDGKGKRTEVRDNQENDLENEEETKEGCDEQCDEQGCFGRGPTKCIACKNKRMDKTCVSTCPPRSYSDSQNVCQPCHEACETCTGPDQKSCLSCSPGHVRVIDLDICLQQCPEGYYENFADRTCIPCQPNCAGCQDRPDHCTSCDHHLLLFQNRCLASCPLSTFETDDYGCGSCHESCETCTGSNSSQCISCPTGRFWHEGRCIKECPAHHYADSQRKECIECPPGCSECNKTTCISCLDDWKVNSKGRCVSQNSDKCDVDQYYDSGLCKPCHSTCDSCDGPTEKACISCASPLILQGTKCVGKCDKGFYNEKDNQVCEPCLHACARCVAKTNCTECKSGLQLQSGECLTTCAAGYYSDKGMCLRCYMSCKTCSGPGTDQCVSCPNGWQLLSGECRPDCPEGYYKTEYGCQKCHYSCRNCPGCKMQEGKRKINVEALLLSAQPVSTLQIVNPFNFITGIAIIACLCVIILFITIFIILQKSTIQAQQRGYSKVSIKKPKVTCNYNVVSVSDADSSDSDSSDGQKLITPKPERTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFL1</accession>
    <name>A0A6P7GFL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114336648</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142810.1">
        <property type="nucleotide sequence ID" value="XM_028287009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFL1"/>
    <dbReference type="FunCoup" id="A0A6P7GFL1">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287009.2">
        <property type="protein sequence ID" value="XP_028142810.1"/>
        <property type="gene ID" value="LOC114336648"/>
    </dbReference>
    <dbReference type="GeneID" id="114336648"/>
    <dbReference type="KEGG" id="dvv:114336648"/>
    <dbReference type="InParanoid" id="A0A6P7GFL1"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028142810.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19382" checksum="FBF76159D6B5B91B" modified="2020-12-02" version="1">MAPPQKGKQGTKGAKQIVEENVATLKFYKYMAIISNAVSLIVLYLLDSGISILLYMFACAIFIGCYQFMAYMAKAKYSETGQLLDSGVDLNMEGGIAEHIKDIIILTAGCQLLALISNYFWYLWLLAPLQGGWILWKNIIQPYISQPTAAEPEVNEKKQKKMERKMKRMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIF4</accession>
    <name>A0A6P7GIF4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Syntaxin-18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114339281</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145707.1">
        <property type="nucleotide sequence ID" value="XM_028289906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIF4"/>
    <dbReference type="FunCoup" id="A0A6P7GIF4">
        <property type="interactions" value="1871"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657729.1">
        <property type="protein sequence ID" value="XP_050513686.1"/>
        <property type="gene ID" value="LOC126889423"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIF4"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000015">
        <property type="entry name" value="Syntaxin-18, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028145707.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35831" checksum="958088829D1BAED1" modified="2020-12-02" version="1">MDITALFKACVKTVRTTNKSLGIRDQKSNILKTHRDIHLSTARDIVKQITKLQSFLLENKAAYLNVINYLSTNKTMSEIDRQKVDTMAEEIINNCSKLIKEYKKEITALSKSSQKEEHYQNVIDSLECYLKNVSKIYTEAKAVRVKRVIETHKLSKLETKPVSQKQEINNSQNKATLDIPNNVSSPKENVRVPPASVDYDNQLSAEEMQMFETENNLLYNELNSISDEVRQMESKVVHIAELQELFTEKVLQQQADIERIATTVVGSTENMKDANEQIRQAIQRNAGLRVYILFFLLVMSFSLLFLDWYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMW6</accession>
    <name>A0A6P7GMW6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114340752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114340752</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147322.1">
        <property type="nucleotide sequence ID" value="XM_028291521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050651825.1">
        <property type="protein sequence ID" value="XP_050507782.1"/>
        <property type="gene ID" value="LOC126885308"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GMW6"/>
    <dbReference type="OrthoDB" id="8197399at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032050">
        <property type="entry name" value="DUF4797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16051">
        <property type="entry name" value="DUF4797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4797" evidence="2">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028147322.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22131" checksum="580FFF50737E31D8" modified="2020-12-02" version="1">MPTSENTLVLMSIVPDHRSISPMTPSPSKEMKGIRLFRAISRKLTRRSNEDLNYQEETDCNSSSSDSCSSTSLGRVTRRKETISADSGFRSISPNHMSSSSSEAGSDIQTRSRHHHSTSAESIRKVFQNLHLNVRSQSCTNTKEKRKSKKPPPKGILRQPVTYTYIKGLSGLPTQRIPKNSKMFQSCGCSMYYRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GUW5</accession>
    <name>A0A6P7GUW5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tumor susceptibility gene 101 protein isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114346752</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153304.1">
        <property type="nucleotide sequence ID" value="XM_028297503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GUW5"/>
    <dbReference type="FunCoup" id="A0A6P7GUW5">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662835.1">
        <property type="protein sequence ID" value="XP_050518792.1"/>
        <property type="gene ID" value="LOC126892919"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GUW5"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="320"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028153304.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44056" checksum="15B8F64A6C3D2D12" modified="2020-12-02" version="1">MATSKLMVYLKKKYHNPDVAYREIINITTQYRGLHPEQSVYTFNDGTRMDLINLTGTIPVRYKGNIYNIPICIWLIDTHPENAPICYVKPTSDMSIKVSMFVDQNGKVYLPYLHDWVPNESDLLGLIQVMIVTFGEQPPVFARAKDNESYPSNSFMPQPSGGYMPPYPTPYPPASGGFGGYPPYPPTSNNSFQGYPPYPSSQPQYPFNFPPGPQAGTGTIKEEHIRESLMTALEEKLLRRMKEQFQQNQAELETLKRTQEELKQGKLKLDGILSRLEKEKNDLDKNITMLQDKEQELNKAIERISNQESIDVDDAVTTTAPLYKQLLNAFAEEAALEDTIYYMGEALRCGVIDLEVFLRQVRTLSRKQFMLRALMQRCRQKAGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZF9</accession>
    <name>A0A6P7GZF9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 T</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme T</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein T</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase T</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114342554</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028149170.1">
        <property type="nucleotide sequence ID" value="XM_028293369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZF9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654367.1">
        <property type="protein sequence ID" value="XP_050510324.1"/>
        <property type="gene ID" value="LOC126887049"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23805">
        <property type="entry name" value="UBCc_UBE2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000041">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028149170.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17151" checksum="987C6513C80494F4" modified="2020-12-02" version="1">MQRQRLSRELLKMSSSPPQGICVYSKDEQYHLEAKLTGPQDSPYKNGVFTLDIIVPEKYPFSPPSITFVTKIYHPNIDDNGRICLDLIKMPPTGSWKPTIGLEGLLTAIRMLLECPNPDDPLMADIAEEFKNHHQIFLEKAKSFTENYAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H0E2</accession>
    <name>A0A6P7H0E2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translocator protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114345274</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151897.1">
        <property type="nucleotide sequence ID" value="XM_028296096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H0E2"/>
    <dbReference type="FunCoup" id="A0A6P7H0E2">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644130.1">
        <property type="protein sequence ID" value="XP_050500087.1"/>
        <property type="gene ID" value="LOC126880333"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H0E2"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028151897.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18618" checksum="18FDD1C682E7B367" modified="2020-12-02" version="1">MQEINWFAVAFIVLPHTGGLAGGIITKKNIFWYNGLKKPFGTPPSWSFSPIWTILYSSMGYASYMVYRDGHGFDGPAGLPLIIYGINLLANWTWTPMFFARKNMKLALYNMQLINATALCMAYLFYKINTTAGLLIIPYLTWLVISTYLNYSFMIKNPPKTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H0Z8</accession>
    <name>A0A6P7H0Z8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 271-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114345509</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152127.1">
        <property type="nucleotide sequence ID" value="XM_028296326.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509599.1">
        <property type="nucleotide sequence ID" value="XM_050653642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H0Z8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653642.1">
        <property type="protein sequence ID" value="XP_050509599.1"/>
        <property type="gene ID" value="LOC114345509"/>
    </dbReference>
    <dbReference type="GeneID" id="114345509"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000161">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001010">
        <property type="entry name" value="zinc finger protein 64 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028152127.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="82179" checksum="FBF3C1BFE6634F5B" modified="2020-12-02" version="1">MEFNIKIEEKIIEHDQRYIHPQLSTSTDFVDLNNEPEGNKSAMELQLKIKEEFVEGSHSYIESQLFTSLDHKEMTNEPEEGSSAVKVKVETKEEFAEDDQECKETQLITSLDLKDLNNEQCEDNLNLGLHYKKNQMEIMKLLPEDSFSINQKSLNSEEVTINNYICSKDFNYKNNLNERMNIETGEGWEMNKCEICFKQFTTTGYLKAHLRIHTGDKRHKCEICLKQFFRADVLKNHLRVHTGETPYKCEICFKRFNQKSTLKTHLRVHSGEKPHECQICFKLFTTTGYLNAHLRIHTGDKRHKCEICFKQFSQQNNLKRHMRVHTGEKPYQCEICLKQFTEAWSLKEHLRLHTEETPYKCEICLKQFSQNSSLKTHLRIHTEEAYECEICFKQFSSSSSLKQHLSVHTGEKHHKCEICFRQFSQQNNLKRHMRVHTREKPYQCEICFKQFTEAWSLKEHWRLHTGERPYKCEICFKSFTRASELKNHMRVHTGEKYTCEICLEQFSASSSLKEHSNVHTGEKLHKCEICFEKFSQKPNLKRHMRVHTGEKHHKCEICFKPFSQQSNLKRHMRLHTGEKPYQCEICFKSYTEASVLKIHLRVHTRETPYKCEICLKQFAKKAGLNYHMNIHTGQKPYKCEICFKQFSQQNNLKRHMRVHTGEKPYQCEICFKSYTQASVLKTHWRVHTAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H786</accession>
    <name>A0A6P7H786_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box only protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114347974</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154422.1">
        <property type="nucleotide sequence ID" value="XM_028298621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H786"/>
    <dbReference type="EnsemblMetazoa" id="XM_028298621.2">
        <property type="protein sequence ID" value="XP_028154422.1"/>
        <property type="gene ID" value="LOC114347974"/>
    </dbReference>
    <dbReference type="GeneID" id="114347974"/>
    <dbReference type="KEGG" id="dvv:114347974"/>
    <dbReference type="InParanoid" id="A0A6P7H786"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028154422.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="39695" checksum="506F321E46742D89" modified="2020-12-02" version="1">MGSLKSKLFDTMEISDAKEAKIPKLYVPVEEFQFHGPLEDDTSNGLFLNDVYFPEEIIIKILTFLPPEQLLPLSLVCKKWCNIIKSDSFWMDVYNNQFPNKAKRLPWYVYYLYYSTDDFRNLLKNGNGQEGFKHWTILKNFGDEFIIEPVPKGSDPLPEGVPEFCGRKSCFTTSFYECCKIQVIRLENKRLLRYVINKFKPHIYVSEWYAGRFDCGCEYKLTIKGLASESMQKPMEDEDLEIEYDRMEYHRTEGDEIVLFSLLKPAIIPQWEGKEWNKMEITVDEYESKTLKTLVFQHEGVDTQFWKGHYGSKMAGGVVKFLFESIQPIEEHIEEPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HDM6</accession>
    <name>A0A6P7HDM6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp70-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114347351</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028153870.1">
        <property type="nucleotide sequence ID" value="XM_028298069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HDM6"/>
    <dbReference type="FunCoup" id="A0A6P7HDM6">
        <property type="interactions" value="1344"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298069.2">
        <property type="protein sequence ID" value="XP_028153870.1"/>
        <property type="gene ID" value="LOC114347351"/>
    </dbReference>
    <dbReference type="GeneID" id="114347351"/>
    <dbReference type="KEGG" id="dvv:114347351"/>
    <dbReference type="InParanoid" id="A0A6P7HDM6"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028153870.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37037" checksum="0A2B7AEF7FA3B188" modified="2020-12-02" version="1">MPVVNTSMALLPVAEASNAEPTENQPRQPMSLQGLLRFSMEATRAEDAPSNSEFAPMDEERKKFLEEALNSMSVDVVQIMQRQIAFLKGVESVDPSECNTNYLEAIETILEYVDNIDIANDFHKIGGFTTIYPCMKSKDSKIRAAGCELLAVLCQNNPYCQTVVLDNEFIPKLLHMIENDNDGQVVTKAIYALGGIVRDNPEGLTQLIHYNGLTMLLNCLKSNHENVIIKSAFLLGTLCRATPNLKEKLTSLGCVPQLISLFLTERSACHEHVMSLLVSVLEDNPVAVDQFKNHSPDMRDSLQRYLSGVNNREECLEEETYCKRLLHILQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I906</accession>
    <name>A0ABM5I906_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028127690.2">
        <property type="nucleotide sequence ID" value="XM_028271889.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271889.2">
        <property type="protein sequence ID" value="XP_028127690.2"/>
        <property type="gene ID" value="LOC114324145"/>
    </dbReference>
    <dbReference type="GeneID" id="114324145"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127690.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="380" mass="43156" checksum="5B9068B7F1293403" modified="2025-10-08" version="1">MLKRGPIKLIQLLRKQTQTAFYSNFSQESLVISKEVGNNAMAILNRPKSLNALTLPMQNEMDKLIRKWEKGKSLVLIRGAGNKAFSTGGNVLIFRDEVKKNTDYLRDIVITLNATNYLVSKYQIPIVGLMNGLTLGGSVSYIMFAKYRVATENSIFGMPEIKLGFHPNSGATYFFNRCAGKLGYYLGLTGKILQSSDIVRAGFATHYCKNNNLEKLQNTLLNCTNKDNIEDIFENICEKRFPEFTLNPVMDRITNCFSATTIEDVLLKLQYDGTPWAKETLNILNRHSPVALKVTLRQFLKGQGLDLKSCLEMEGNISINFYKHPDVFEGIRVTLEDKHDNPSWNPPKLSDVTEEMVDRYFIPVVEDLQKTLLKEVDERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IA46</accession>
    <name>A0ABM5IA46_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128356.2">
        <property type="nucleotide sequence ID" value="XM_028272555.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272555.2">
        <property type="protein sequence ID" value="XP_028128356.2"/>
        <property type="gene ID" value="LOC114324718"/>
    </dbReference>
    <dbReference type="GeneID" id="114324718"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045153597" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128356.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="133" mass="15499" checksum="8703F8A341623671" modified="2025-10-08" version="1">MFVLLIFLAGIICSKGINEVCFLQGLRGVCQPLRVCYQALDLFTDDIGNFCQFDESEDHICCPDKFRRPTRKPPSPKPQYVKGRPKRPHNQELPPFRVPEQDPDKPSYKTRKPYRIPINANVNRKKRTIVNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICW8</accession>
    <name>A0ABM5ICW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130067.2">
        <property type="nucleotide sequence ID" value="XM_028274266.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274266.2">
        <property type="protein sequence ID" value="XP_028130067.2"/>
        <property type="gene ID" value="LOC114326068"/>
    </dbReference>
    <dbReference type="GeneID" id="114326068"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130067.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="57465" checksum="A10B3C25E14E011D" modified="2025-10-08" version="1">MSLLTNNNVIDVIVLLATIVLLGIAYVRYCYGYWKRKGVVQLRPQFPLGNYGNNLPRGISIGAVTKKFYDEFRRKGLKFGGVYLGLDPYLVIVDPIYAKDILTKDFQYFTDRALYFSKKSPITVHILSQEGTEWREARAKFTNIFTSAKMRFFFETLKKCSEDLQSTLKEYVDQDKDVDIFETVACYTTDIIGDVVYGIQAQSFSKEGAIFRQMGRELFNVFSKFFQFKILITICYPKIAKMLGIVNIQGHIGEFFMKFLKEAMDVRVANKATRSDFLQLLIEMKNSGVDLTDDEMASQAFLFFTAGFETSSMSSSLTLFELSQHQDVQDKIREEINAVLKKHDDKISYDVLKEMKLLDQAFNETARKYPVLSTITRVCTKDYKLEDNDFVIKKGTPVLLPLLGYTQDPEYYPDPLKWDINRFQDKDEKHLGYFPFGDGPRICMGSRFGLMQVKLALVSVLRNFKVFVSPNTEIPLQFDEQTFVTKTTDRIFLRLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE45</accession>
    <name>A0ABM5IE45_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130812.2">
        <property type="nucleotide sequence ID" value="XM_028275011.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275011.2">
        <property type="protein sequence ID" value="XP_028130812.2"/>
        <property type="gene ID" value="LOC114326597"/>
    </dbReference>
    <dbReference type="GeneID" id="114326597"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130812.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="454" mass="49717" checksum="32E96898E192D935" modified="2025-10-08" version="1">MLLPSFKYVYVSAAAASLLMFMAGTACCWSSPEIPKLLNVTENPFGRAITPEEISWISSLLTLGAAFSPFLYGFLADSIGRKPSMLLVGVPFFLSYVMLATGTVIEIYYVARFLSGIGVGGVFTLVPMYIGEIAESRNRGLISCLTGAVCAIGLLFSVSLGPFKSIQFFNTVLAIPPLVFLIVFSLLAEESPIYLVKKKKCDKAEVALQNLGRTTEVIKKDIMEMQAEYENKEDDKVDIMEMLSSKALLKGIIASVGLLVFQQLSGINAIMFYSQTIFEAAGSTIPPHICTIILVGVQFVSSFIVPFVVDRFGRKLCLQISALGMIASSGPLAIYLYIRTAGYNVEDFSWVPVLTLTTFIVFFNFGYGPLPWTVLSEMFSTKYRSLASAFVSTICWLVSFLVTKYFGLAVATFGLGNVFGFSTVCCLASVIFCWLCVVETKGKSLQEIQDILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IF62</accession>
    <name>A0ABM5IF62_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein subunit beta-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131444.2">
        <property type="nucleotide sequence ID" value="XM_028275643.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131452.2">
        <property type="nucleotide sequence ID" value="XM_028275651.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275643.2">
        <property type="protein sequence ID" value="XP_028131444.2"/>
        <property type="gene ID" value="LOC114327130"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275651.2">
        <property type="protein sequence ID" value="XP_028131452.2"/>
        <property type="gene ID" value="LOC114327130"/>
    </dbReference>
    <dbReference type="GeneID" id="114327130"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131444.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34901" checksum="C59D8161764AD4E2" modified="2025-10-08" version="1">MAVLPPDPVFCYKEDMGQIHSLNFCVRGENFVSHLLAGTEKGGVYFWDLETNRLHHKQAMGKSIQAIHTFDYKVLTQEKEGSVKLWSVRKSSYEVEKETTCGIGFCKSILINEALIVPQENSCVDVLQVTDLTKIKQLNPGRENLGQVMALQKVTIGNSCCVMAAYETGDVVLWDLNTFQPCGHIKLQEHLTSLTFDPYTLRAVCGAASNMLQVFTIDSCYQMALKAEVSITNEGCNIVKLRPDGKVLVSGGWDGRLRVFSWRTLRILAVLAEHKNTIMDIQYSPHPVNYWKSNIMAACGGDGVISLWNLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGR3</accession>
    <name>A0ABM5IGR3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein DDI1 homolog 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132391.2">
        <property type="nucleotide sequence ID" value="XM_028276590.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276590.2">
        <property type="protein sequence ID" value="XP_028132391.2"/>
        <property type="gene ID" value="LOC114327878"/>
    </dbReference>
    <dbReference type="GeneID" id="114327878"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="12">
        <location>
            <begin position="220"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132391.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48912" checksum="EAFB01969638B40A" modified="2025-10-08" version="1">MKVTVTTLTDFIFVLDVSEDLELENFKAFCEIESGFPASEIAIAFNGMPLMDNKKSLKDFGINDGDAVILQHIQSESQMDQSGNLDFSNIEVPNTTNNTRNRQVEDDPVLIREMFLANPDQLALLKQNNPRLADALLSGDIDNFASVLREQVKARQDREEQRLRMLNADPFDTETQRLIAEEIRQKNIEANMEAAMEYNPESFGTVAMLYINCKVNGYPVKAFIDSGAQTTIMSSRCAERCNLMRLVDTRWAGIAKGVGVQKIMGRIHMVQIQIENVFLTTSFSVLPDQPMDMLLGLDMLKRHTCCIDLKTNVLRIGTTGTETPFLPESELPDCARLSSLSEEEVALRSKKEFEEKQLQTAVKNSQQDSSPFGASTSNAASAATTPTQNETFSNFTEADISDLVSMGFSREQVIFELKRFNGDKTQATAALFAKSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGW4</accession>
    <name>A0ABM5IGW4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132470.2">
        <property type="nucleotide sequence ID" value="XM_028276669.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276669.2">
        <property type="protein sequence ID" value="XP_028132470.2"/>
        <property type="gene ID" value="LOC114327953"/>
    </dbReference>
    <dbReference type="GeneID" id="114327953"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF4">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046494132" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="116"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132470.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="416" mass="47030" checksum="A6A2D16F7077C7F9" modified="2025-10-08" version="1">MKKVNKIWFYFHWILIYGKLSVLAKPAVKTDIWQDKNDQEEEQFVNNVNFSSAVNHSRLPRVLNFFPVPVEEECNANDGRRKGVCMNTYECRMKGGKSYGFCAYGFGVCCVFTATCDQEISNNITYFVNPDFPDLTRDMSSCSLKVKKMDEEIGQLRLDFVHFNLGQPNRKNGICEEDIFLMTTGSNSRDITLCGLNSGQHIYFDVDNTNDFIEIKMNMSRKAVTRLWEVKVTQMPFSQRAPAGCLQYYEGTTGIIQTMNFADNGRHLANQDYNICIRQEDAMCSIVYEPCHENAFRISPNSGDDYMEVGSGDYTDDDDEAGIVEGRQMDSCGDKITIPCESDDLLLSGEEDMIQGICDVIHCGSTLCPDGEDPCRIESTVTPFVVGVHFGRTVREASPEENLGMCLTYEQQDCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IH00</accession>
    <name>A0ABM5IH00_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028132553.2">
        <property type="nucleotide sequence ID" value="XM_028276752.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276752.2">
        <property type="protein sequence ID" value="XP_028132553.2"/>
        <property type="gene ID" value="LOC114328013"/>
    </dbReference>
    <dbReference type="GeneID" id="114328013"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF32">
        <property type="entry name" value="IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046490052" evidence="9">
        <location>
            <begin position="16"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="464" mass="53511" checksum="E29E1EC19CAC83B2" modified="2025-10-08" version="1">MKVVLLLSAVYVARALTINKRLCDNRKLYESMDKISVWHEGEQEFKTILWHCIQWRRAAWNYDADADTKIKVLATDALPYIKPSNNSAAIQGYVGDIFIIIVEAFKMNFVMYNVRYHEGVSFVNDGLGDIYLGGTIATSDFKNILISQPYMMNSYRLYMKKPRVDIDTYFYIKSFSKNLWRVSFLVFFTMSITIWATGRLLKKYKTKEPCVSLPICLIGAMSGVLNQGYDLGFKSYAARIQIYVSLILGVILYSAMSAVLYSKMAVVQSPWPFDSLEGIPGTGLSLCMRNNSWVYKTVYFTDQEKVLQPMWQNVINTNHCIGFENSSNIVHIMCNNPVVVLENKVIMSSVFRNKLPCDCAMIRTEYFKLGLVIYVRKHLKESPSISKMIIKLQGAGILKYLEEKWTYKHRGGSDPEQWYAVTFKHIEGILVFYFQMVVFSLFVLGIEIIWKGEIFKYNEITCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5II83</accession>
    <name>A0ABM5II83_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028133405.2">
        <property type="nucleotide sequence ID" value="XM_028277604.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277604.2">
        <property type="protein sequence ID" value="XP_028133405.2"/>
        <property type="gene ID" value="LOC114328684"/>
    </dbReference>
    <dbReference type="GeneID" id="114328684"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133405.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="367" mass="40988" checksum="8E9B92829F43BC83" modified="2025-10-08" version="1">MASTSTSEVNAGNSNKPVCLIVLGMAGSGKSSLVTRLASSDKKPYAVNLDPACSNLNYFANIDIRDTVNYKEVMKQYNLGPNGAIVTSLNLFSTKIPEVIDFIKKSQNELCILDTPGQIEVFTWSVSGSIITDTLASSFPTVILYVVDCVRSTSPVTFMSNMLYACSILYKTRLPFIIVMNKIDIVDHSYAKDWMTNFEVFQEALESDESYISNLTRSMALALDEFYQNLKVCGVSAATGQGIEDLYKLVDKAAEEYENEYRVEWEKLKAESDAKKAEQNKEDKEKPNADTSSGSLITELPNGRELSDIYLRHPTNESSTDSEGEEEPFNAVNNEEEAETFQKVLNQQRMMQVKRAKEAEMKKSQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILA3</accession>
    <name>A0ABM5ILA3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028135508.2">
        <property type="nucleotide sequence ID" value="XM_028279707.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279707.2">
        <property type="protein sequence ID" value="XP_028135508.2"/>
        <property type="gene ID" value="LOC114330366"/>
    </dbReference>
    <dbReference type="GeneID" id="114330366"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135508.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="502" mass="54688" checksum="E764D30BE74BACCE" modified="2025-10-08" version="1">MLFQRVKVRDIVRFHLISRQMHLSGKTYINGEWVSAVSNKTFEVINPVDGSVIDRVPDMDVVDAQQAIEAASNAFQSWKNTTAKERSSLLRNWYNLLVKNQDRLAKIMTAESGKPLAEALGEVNYGNAFVEWFSEQARNVRGEIIGSSNPSKKFLIEHYPIGVAALITPWNFPHAMITRKASPALAVGCTVVIKPAEDTPLTALALAQLAEEAGMPKGVINVITSNRQNAPAIGKLLCQSPLVAGISFTGSTQVGKILYQQCASGVKRVGLELGGNAPFIVYNSANVDKAVEGAMMSKFRNCGQACVASNRFLIQDEIYDRFISKLVEQTKNLKVGNGVDCGINIGPLINQTHFLKVSELVNDAISKGATVLAGGKPAPNLGNLFFEPTVLTDVNDKMKVYHEEIFGPVISIVKFKTEEESLKIANNSERGLAAYFFSEDVNQIFRVNKNLEAGMVGINDGLLSAVEAPFGGIKESGIGREGSHHGTEDYTYLKYTCIGNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPW5</accession>
    <name>A0ABM5IPW5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138426.2">
        <property type="nucleotide sequence ID" value="XM_028282625.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282625.2">
        <property type="protein sequence ID" value="XP_028138426.2"/>
        <property type="gene ID" value="LOC114332847"/>
    </dbReference>
    <dbReference type="GeneID" id="114332847"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138426.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="190" mass="21469" checksum="326E054E74D0B4DB" modified="2025-10-08" version="1">MSCEIVEIIGTGDYETYEKISKNQSNFATVLASELVSDIIDNALDIVEDKDRQKMNTSGDIFENLSNKFQGLVITEEQRYMEGVPAASSKILLEGIGDQLQREQEIEKEAVIKHPPVEKKNRLSDLVKNSKQLLTKIMHAESKAELSDAKSEKVVKVVDLDAVEVPYKVKKILKPEDVLLPGKYFYTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR43</accession>
    <name>A0ABM5IR43_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139293.2">
        <property type="nucleotide sequence ID" value="XM_028283492.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283492.2">
        <property type="protein sequence ID" value="XP_028139293.2"/>
        <property type="gene ID" value="LOC114333596"/>
    </dbReference>
    <dbReference type="GeneID" id="114333596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="16"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139293.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="476" mass="52194" checksum="9A9C992437249B74" modified="2025-10-08" version="1">MGIQKYSGSAFYQYVAGFSATIATLVSGMHYGWPAPSLPRLLDGTSYIHINEDIGYWLATAPLLGTLVGSPSTPLFIDRIGRHKTILLTGLPYVLSWFLIYFASSYELILAGRLLAGVADGWMFCSVPVYIGEIAEPRIRGFLGSLISVSYIGGILLIDIIGSFCTVPVTALISALFPIVMVVIFFFMPESPYFLVMKGDNEAAIKKLQILRGTNNVEKEIARIQEGVQEEQSVKSNPLDLFRIASNRKAVIIILAIRICQEFSGDSAITFYTQNIFREAGTDIPEDIASIILFVIVLIVTIFAALLADKFGRRPLLIFSAAGAAISLLVEGVYFYLKICTDLDLSDFNLVPLVALISFVVCLGSGLKVIPLLMLSELFPASVKGASVAVADVSTAGLVMLVSKYFQFTRDHFGMYVPFISFAVFCTIGLLYITLCVPETKGKTLEEIQDHLKGIKRIDKKNIESQLSTVHKSVHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISK8</accession>
    <name>A0ABM5ISK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Circadian clock-controlled protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140682.2">
        <property type="nucleotide sequence ID" value="XM_028284881.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284881.2">
        <property type="protein sequence ID" value="XP_028140682.2"/>
        <property type="gene ID" value="LOC114334786"/>
    </dbReference>
    <dbReference type="GeneID" id="114334786"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF14">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047160382" description="Circadian clock-controlled protein-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140682.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28984" checksum="76B08C3E9DCA1150" modified="2025-10-08" version="1">MKSLLLVICCCAFYNVVQGRSLQQLPEYLQKYSCKESEPDYGKCVWEGFHNVWPFFMKGIPELGVLGLDPFRMKMFAVNSTVGNLIKIDAVCENAEVTGLANTVIQDLKADPIKHYGEIRLFIPWMYANFDYDVKGQLLVIPLESKGHFEGNFTETQVLVKGDLKTYLKDGVEYFKTGKLYLKARIGNGWVKLTSLEKEFQYAADIITDFYNENPRRVMDAINPIFIQYSKAFARQEMDKILSKLPAAAWIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IVR8</accession>
    <name>A0ABM5IVR8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144145.2">
        <property type="nucleotide sequence ID" value="XM_028288344.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288344.2">
        <property type="protein sequence ID" value="XP_028144145.2"/>
        <property type="gene ID" value="LOC114337810"/>
    </dbReference>
    <dbReference type="GeneID" id="114337810"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144145.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="706" mass="81623" checksum="E30605994E8929EA" modified="2025-10-08" version="1">MSTSRGRQMVTNARNDVIVHVLNNNIKDTIKCAIKTNNEEATVLENTDADELGPTLLSLEQEVAAANLLLLGESAVTNETFSTDINNVTDGLPKESDFEKVSNWLRNIDNERLDCDAILETVSNEISTNELSRDKTHLEELRNDVALNHEGILNEVMSSSSSVIADQIDESWLPENENKSDYSTSSEEGKQQEGEEPVARADNDGNNENKKARKRIADINEWHDIKNKRLRQHGKKYIGWTRVGKTAKRGTPRNEKQMGPVCLSSVCKKSTVRQCQDLNEEDRKELFNNFWNNLTWDQKKIYIASLVCKKEKNRNTKKETEESRRKNTLTYTLKTLDGKILTVCKKLFLSTFALTEHYVFNCLTSETKHGMIAATEVNNERRREKRKIAEIRKETQCNKSSNSAKDVLRNFLHSLPKLPAHYCRKSTSKLYIEPIFGDNMSKVYQEYSRMCREQNKELKPVSRYTFDLMVKEKHISFHIPKKDRCDTCCSYETNNLDENVYKKHINNKEKARQEKENDKQAGHVKQCIVLTQDLQAVKVCPMLNASALYYKTKLCCHNFTIFNVNTHHVRCYWFTETEADLSANTFATCITDYLLDLCPVNIPIIIWSDGCTYQNRNATLSNALLSFSVENNVIIYQKYLERGHTQMEADSVHAQIEKTVKYKSIYLPSDYIRLTKESRKQTPYQTKEVTYDFIKKIFRNFSIPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IW24</accession>
    <name>A0ABM5IW24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144767.2">
        <property type="nucleotide sequence ID" value="XM_028288966.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288966.2">
        <property type="protein sequence ID" value="XP_028144767.2"/>
        <property type="gene ID" value="LOC114338378"/>
    </dbReference>
    <dbReference type="GeneID" id="114338378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026797">
        <property type="entry name" value="HAUS_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16151:SF2">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="391" mass="45144" checksum="8CB3883794713367" modified="2025-10-08" version="1">MSDAKTFRNLEAKLHEELYNNLYLLTRVYETHSEFDRVFKRDMFVKKNKAAFYEVVYYLLDALNRELTKEKLKSWRPYDIKGETKFRSELLKYINELNNHYTHANIPPIMASHLISPGGFKFITFMLKLSQLVIFEYLQNNSRALLLYCLTPSSNATVRKAQFDNIKRITSEVKLRTNTATKKFQEDTNKQKNVADSLVKSLTDLDKSISTAKKVQLAAEEEIFNKYTVYPSINSLEDKIASLNSLWSSLSNVHSVLEDCKSIHEYLASNDLVLHHTANSQKTPNCQKEQKLNLPEFLTTVATLLNSKSLELPILDKSFISERSEQIRSTAEKYQDLINEFNTDIQQINAHAKGLCKNLKSVDNYVKLQLINNKVESSEDNLGIQPLEYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IW37</accession>
    <name>A0ABM5IW37_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144785.2">
        <property type="nucleotide sequence ID" value="XM_028288984.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288984.2">
        <property type="protein sequence ID" value="XP_028144785.2"/>
        <property type="gene ID" value="LOC114338393"/>
    </dbReference>
    <dbReference type="GeneID" id="114338393"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144785.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="182" mass="19886" checksum="94DA6452839A02A2" modified="2025-10-08" version="1">MSDGTFLVCLTGQIEWIDILATSGTSWHCKYEFSSGPDWKVSGGLESGLSQVANIVNNGDKVVLNLPIEIQFKSTNPYGWPQIVLSVYKNSTLAGYGRCHMPIKPGIYKLEVFLSKPQASSMLGYLASFFGYQPELLQPKMLATTAGNNLLLMETTGHALISINVITQGFQNLGYDRGAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGW3</accession>
    <name>A0ABM5JGW3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497180.1">
        <property type="nucleotide sequence ID" value="XM_050641223.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641223.1">
        <property type="protein sequence ID" value="XP_050497180.1"/>
        <property type="gene ID" value="LOC126878475"/>
    </dbReference>
    <dbReference type="GeneID" id="126878475"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045630369" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="143"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="389" mass="42836" checksum="0A02D561D2A640D8" modified="2025-10-08" version="1">MKHKLIFLFVYFVFYNDVYAQVGDRCTFKGTTKRGVCKEITKCPAAEEQAKQGTDDVTLCGFANDLNTAIVCCEVTVEPNDNLLPADFDTNGETSPPGKMSERKCQEYSKAITSEVQFLSLVSDATPMSYRTPKCDYNTVPLIVGGTPAEAGEFPFMVAIGFNTTSDRWRCGGTLISTRFVVTAAHCCYTRDAGKPSVVRVGELDLASDQDGSVYADYLISRVIVHPGYSAPYKYNDIALLETQQPVVFTNFTRPACLNLNHNVAQSQAIATGWGKTDFAGDASDRLLKVTLNLYDNQRCQRTFPPNNKELPRGIESTMLCAGHLEGGKDTCYGDSGGPLVVTKKGNMCQFFLVGVTSFGKLCGQKNTPAIYTRVSEYIPWIERIVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHH9</accession>
    <name>A0ABM5JHH9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497393.1">
        <property type="nucleotide sequence ID" value="XM_050641436.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641436.1">
        <property type="protein sequence ID" value="XP_050497393.1"/>
        <property type="gene ID" value="LOC126878615"/>
    </dbReference>
    <dbReference type="GeneID" id="126878615"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="139"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="564" mass="61826" checksum="B26E5CF750DDB0C6" modified="2025-10-08" version="1">MESFFSLFEPTYNDCPHSEEFGLDNMNNRTSLPPEPQLGNVEYKLKIVNPTKQRFEHLVTQLKWRLREGNGEAIYEIGVEDSGILAGLSTRDMNASLQTLKQMAIKLGATTTILRERVLDNGRSVAEVLVRKVPDDQNNIEIRIAVLGNADAGKSTLLGVLTQGSLDNGRGRARLNMFRHLHEIQSGRTSSISHEILGFNSQGQPINYSYSELITAEEICDTSTKLVTFMDLAGHKKYLRTTIAGLTGYSPHHAMLLISSTAGAVGMAHEHLAIAIALNVPFFIVITKIDLASPTTTLQNLESFLKQVGTRRIPLVIKTVDDVITAGANQLAENVVPIFLVSSVSGAGLDLLLKFLHVLPPGISAKEKERLEQESPEFQIDENFKTGDVGQIIGGLLTKGVITEGTKMQIGPLKDGSFQKVAVKTIHRNRVPCRMVRAGQSASLGLNTYIPGLRNGMVLLSEDEDAKACLFFQASVSVLFHATAIYPGFQTTVYIGNIRQTAVIMGICSSRCIHTNERDSVLFRFKLHAEYVAVGQRLLFKEGSSKGIGEITQIFPLTPPLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIF0</accession>
    <name>A0ABM5JIF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497718.1">
        <property type="nucleotide sequence ID" value="XM_050641761.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641761.1">
        <property type="protein sequence ID" value="XP_050497718.1"/>
        <property type="gene ID" value="LOC114340291"/>
    </dbReference>
    <dbReference type="GeneID" id="114340291"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039895">
        <property type="entry name" value="COBL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557">
        <property type="entry name" value="CORDON-BLEU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557:SF2">
        <property type="entry name" value="CORDON-BLEU PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="1715"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1675"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1675"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1737" mass="193946" checksum="4500735C454DBFE5" modified="2025-10-08" version="1">MMQITEDTPPDMLAGAMDLIIHLPTGRNVKMSVERSTPMMDLLVQITTTHQLQLSNYTLQTLGVAPSSDRSDKILPYTPNTPIGTLDTQHIKVVPKTKSVAVPKNIPPGHQPFESTFRLKVHLPRNQLYVTRVSRNVLLEDIMKKVCEEKNLDPLKYEFKHPGNINETLDPKLTLSDYQITEIYVVGKGTHSLTQAFSSSDIMALRKEEERKQMHNKTGGGVFNLIFRRGKSSMGSGSISSDTRSISPTHSDDSRSVTPPAVIQQPILPPPKQDPPPERPKPPQRKRRPAPRPPQLTPPQQEIPKEETAIDAEDSKESRRNSEEKPASTVSEVSELQSKKIETGLVICHSRNSSDSSGYHEASVLSDNCNTSLPRRPKSAFVGSTDIEKLSKMHSQSTTNLTKMASHSKSTTSLGLTGRKKKAAPPPPPAVRASNPSINLEPASPVVASQSTTHTKATPSTSLDPLVAPNLPKPLPRGKTKAPPVPRPRSEIITVETIIEDIDDTNNKPSKVLKIDNDVVQEVIKEVVSAEVGTESSTLKKDIIVTVEQEIETLNDEITKEKGSDISELAEIPTLDDSEDISHDKNEEKYKIEDSKNTSELVRSSLDVDIDANNNTNSSNVTEYSEKLAYDKIRELQKISHGLLFSSPAFKRHKEQESRTTKPISKSEKIEDVKEKSIHKDVNNVTADVKETVLKQDIARINKTRNDAEIQEDIKVDCKDDEAIKDIRETVLLPEQEIQIENSVNVLPDIEKKVVATEVTPETKIEEMQSNVKQESSELGPISSELTLSKKLPPEIVAVIPKTLSDKKLNPSNKYDSFGKRRVQKLFSISSLSEDENGSKSGSVSSRTSVSSALGAFNFVDEFSDLDDKVFTGSISKNFSLKDEDFFNELYGIHHLEDFQLKKNQSVCSLRSLSSLPGFLNSGSGMRKWVNTEGLDGLSISEDPNFRWVIGDSEPESLSSHQALDNLASITSCAIDTLTDSTDVIKPFGSTDSGIAPETNEKLSEVEDLRPITPPPPPIFVDEPTEFVEPGKEPHEELQEKVEERLEEALVIEEAEKSIEPISETITSENESLTELGIETEKENLEEIDWQYQLPSPPKAFRDSSPIRNEDTLSEAKSVSITDFKDSVVTSPELFEKLKSIEDTQSVQSVSTFVGEEPPLNTLSLENLEKRKTLVYNRELSSLKMNEKNTFSHSLNKFERTYIEVQKSSQKEMREPKFVPKSNTNTLPNFKISTYDRPKQKIKVFEDDTVRSNTEYINRSKETVIERQTYSSNVNRSFAATSMENISARKISVDSQPEEREYNFFRPDKVNTARNFGPVSSVFRSESFSKENTWSPPKPVSRSKSFLTLNWQGKYKIEKQNKEGEGMERINSLYDVSGLQSLGVMRLIQNKLNTPTTSLENINAPDQSKAKIDHPRETPITKLSPVETIEKPLSTERIYKYRGPPSINMGTWCDRPKVPVSVKEDEDYTLGNTVSTKLIVNTTNNNVTSNNRIEIKTSNKEVQSSNEPSISIKVNGSEVPTTTTDTKTGNVVIKIGPSSNSQPKIIDNQTFINHTTAVGYRKPFNDINKNQRPYSIAFSSEYDMSRVPVVRSVELKKPFKDFGNTSVTQISPDATADNKPHNGFLEDRKAALRINSFTPHGAPVVRGFKSLPKQKESFQPNSQVPFSQVTLRRTESSKILNEPKEPEVKPPPPPMMPKVSLKKPTIKHVEPILDPRDQLLSQIRNFGGKKGLKSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIT8</accession>
    <name>A0ABM5JIT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497854.1">
        <property type="nucleotide sequence ID" value="XM_050641897.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641897.1">
        <property type="protein sequence ID" value="XP_050497854.1"/>
        <property type="gene ID" value="LOC126879017"/>
    </dbReference>
    <dbReference type="GeneID" id="126879017"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175424" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="251" mass="27474" checksum="E21AC4840BD897B5" modified="2025-10-08" version="1">MVSLYSKIVSLVYILLLKNNFVHAGKRVRIFSGQETYIEKHPWIVSLLHPSDGMHNCGGSLINADTVITAAHCVHNKTSEPVSIIAGTSEWAHPGTIIKIKSISMHENFSTDGRTAKNDIAIIKLAEKVKFSNKIQPIKLPPETTKLSEGTSLTIAGWGQTTIWNSLFGTPTMTLMEAKVTVSKSENERIIITSDRSGSCPGDSGGPLELNGMLVGIVSSGRRYCTDFFPISSSYTNVAFFRTWITEKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ66</accession>
    <name>A0ABM5JJ66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497978.1">
        <property type="nucleotide sequence ID" value="XM_050642021.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642021.1">
        <property type="protein sequence ID" value="XP_050497978.1"/>
        <property type="gene ID" value="LOC114337066"/>
    </dbReference>
    <dbReference type="GeneID" id="114337066"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF14">
        <property type="entry name" value="BEATEN PATH IV, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="56"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="307" mass="34728" checksum="78EEC6166C1DC84F" modified="2025-10-08" version="1">MRLRFSIFFSWWATMGPKSLQLVCYHFLAGLVWTLSASNNGLKWVRVNVPQYRIPGETAMLQCDFDLGNDTLYAVKWYKEHEEFYRFVPKSRPQANSYEVEGVHVDMSKSDKKKVVLHPVSWRTSGVFRCEVSAEAPSFASAQSEARMEIISLPEEDPIITGVEIQYQIGDIINLNCTSGKSHPVSILHWYINEQQIQNSEALIYYPPSHHPKGLMSSTLGLSFTLSEQHFRGGSMRVKCVASIAPILYRSDRESVVQSENVPLREALLLGEWSIYVEKYDVKSSATLRVSCMATLLLALAATHLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JME6</accession>
    <name>A0ABM5JME6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499100.1">
        <property type="nucleotide sequence ID" value="XM_050643143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643143.1">
        <property type="protein sequence ID" value="XP_050499100.1"/>
        <property type="gene ID" value="LOC114334869"/>
    </dbReference>
    <dbReference type="GeneID" id="114334869"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF255">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ALPHA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="343" mass="37759" checksum="920650DDABE85BB1" modified="2025-10-08" version="1">MCQINTDPMKSQVGYLDVSVPPDFIPEDTSGDVMVPEGGTVKLTCRARGHPDPHVQWRREDGHDIVIKEPTGLKTTVSSYQGEVLKLWKISRTEMGAYMCIASNGVPPTVSKRIMVNVHFHPVIHVPNQLVGAPLGTDVTLECNVEAYPKSINYWVRDTGEMVISSSKFDVQASSKSLFHVKMTVIVRNLQRDDAGSYRCIAKNSLGEVESNIRLYEIPGPTRGYSLSLDEEDYNDQFGSAEKEQDEEISNSVLERSRSASQYSTVETPSRANYVDSQNVVIAVPSVSPSSAASMLPSRFDMARSVGFVLTLSRFLPVQSTGSLIVVLAAIVALFPYLMATMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMR7</accession>
    <name>A0ABM5JMR7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499232.1">
        <property type="nucleotide sequence ID" value="XM_050643275.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643275.1">
        <property type="protein sequence ID" value="XP_050499232.1"/>
        <property type="gene ID" value="LOC126879925"/>
    </dbReference>
    <dbReference type="GeneID" id="126879925"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047001294" evidence="2">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="358" mass="39972" checksum="7D15E4F23F1B7BE5" modified="2025-10-08" version="1">MLKTEYSITLIFSLIHVGHTIPPGENGKDLPNNFHLEQYQSRIKIPTGSGAASGSGCKFGKKPVKIYKTDGNGKTFLDIQYINVGYNYEYNINCGTVGGSESQYPSQDDNAITYGGGHKPHRPIFGGHHKPGFGNHHKPGIGNHHKPLGGNHQGTASEDTDLDETHNTNRPNRPFLSNFFGNRPFQNIFGQSHQSSEAQQPGVFNNIVNSFTSILPSPQDFGQGLGDGISSFILTIPQIGQSFQSLLPNFGNFFGGAPSVQNIPNPPSPVDPGDMTYNDEIKPVHEEHDPVTDPYKNRLRPATNFYPKYQNYHSRIRQEDYKISSRSFDRDVEEMINSRSFEGRRTQYKDNRNIKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMS5</accession>
    <name>A0ABM5JMS5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499241.1">
        <property type="nucleotide sequence ID" value="XM_050643284.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643284.1">
        <property type="protein sequence ID" value="XP_050499241.1"/>
        <property type="gene ID" value="LOC114337529"/>
    </dbReference>
    <dbReference type="GeneID" id="114337529"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1034" mass="97969" checksum="721B6089EED6CAC8" modified="2025-10-08" version="1">MATFLYKKTKDELVVSSKSKMDHKQFYSILFCILVGSTLGHEYQRAKYFAPQSSSKLSHLTKRAADDNSKQCQLDCSGVKPKGNIELYFNSTTYIIAVVNITARVAWIFDFNTNISLIADGNTGGGIVFNVETNDGLYIKSSKNPLLWLPGVLFEDYSSSIVSLKALLTLDGVKFNLKKPGTEQLTVINQLVIKLALNLDFSHDNSAGLNLIVRIVKNFQSFHSGSLNHLYKILTGVVKIRVTGDIAFLVSVLGGLAIIVEKLGGVDALLKAGVTLDLNGLLGADNGIEALINILLALGGKVDLAPLAGILNNVESLLGLILQLGGGLVTGVTGVVKVLLTILGVVSKKLDLKDLLQVLIEFAAAKGEGVTIEIKVYLGALLNVLKQLNLGELLSGLVSTVEKILGGTLIILGVNIAAILDLLISVELLKLTLIVRVLLLLGSVVKTVLSLPALLFHLIGLLTSTVGITLLLSLGLVKKIVSVTDIVKEIAKSQVKILLNVLNPIGLLKSIPFVGDIYIEVSVTVKTASGGKEDLDSSVKSDHSFLGNLVIWVKGLLGVDGVTTPKPTTTTTDASGGWGNGVFGKIIGGIFGGNSGSGGSSGGGSGGSSGGGSGGSSGGGSGGSSGGGSGGGSGGGTGSGGIGIDIGIGGGSKGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSQGGSGNQGGSGGGSISIGGGSGSGSDGKGSGSGSGSGSGSGSGSGSGSGSGSGSGSHGGSISIGGGTGSGSGGSGSGSAGSGSGSGNGGGSGSGSGSGSTGGSGSGSTGGSGSGSSGGSGSGSGKGGWNIGGGIGGIIGIGGGGSGNKGGSGSGTGSGTGSGTGTGSAGGSGSKGGSWSWSWGTGGESSTESGGKGSGSGSVGGSGSGSSGGSGSGSSGGSGSGSGGAGGSGGSSGSGSTGGKTGWGWSLGLGGSSGSGGSGSGSGGSGSGSGSGSGSGSGSGSGSGSGGGSGSGSGSAGGKLGWSWGGSSSAGGSTGGHKGWSWSAKSHEGHKNHHDRHHKAEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ53</accession>
    <name>A0ABM5JQ53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500066.1">
        <property type="nucleotide sequence ID" value="XM_050644109.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644109.1">
        <property type="protein sequence ID" value="XP_050500066.1"/>
        <property type="gene ID" value="LOC126880313"/>
    </dbReference>
    <dbReference type="GeneID" id="126880313"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
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            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="523"/>
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        <location>
            <begin position="607"/>
            <end position="634"/>
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    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="635"/>
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        </location>
    </feature>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
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        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="830" mass="96646" checksum="3B47C6099146D107" modified="2025-10-08" version="1">MECNEDIKDCRNQEILTGIKDEGDSVQKYNNIEVKSELDENSYAQECVLDDYCSEDIKIENHAVVSNNEIKVEIKTELEEHSIGAPPDITMGLAITKPFNSAQVHLKTCTGDRPYECEICNNLFTTKGAPPDIRMELAGTKPLNSANVHLKTCTGDRPYECEICNNMFTTKFNLKMHMRIHTAETPYKCEICHKQFNQLNSLNYHMRDHTGGKLYKCEICSKQFTIKRNLNTHANCHSSKKPYKCEICSKMFTTNFNLKVHMRIHTGETPYKCEICTKHFAQKISLNAHMAVHTGKKLYKCEICTKPFTTKSNLNTHMKCHSSEKHYKCEICSKMFTSKGNLKVHMKVHTGEKPYECEICIKQFTTRSYLNIHMKCHSSEKPYKCEMCGKMFTREGALKMHMRIHTGETPYKCEICSKQFGHLSGFKYHMKVHTGEKPYECDVCTKQFTVKSNLNAHMKCHSSEKPYKCEMCGKMFTREGDLKIHLRIHTGETPYKCEICSKQFGRLSGFNYHMKVHSGEKPYECEICNKLFTLKSHLKRHMRIHTGETPYKCDICNKQFNQLVSLNYHMRNHTGKKPYGCEICSKMFTTKDELKMHMRIHTGETPYKCEICSKQFGRLSGFNYHMKVHSGEKPYECEICNKLFTLKSHLKRHMRIHTGETPYKCDICNKQFNQLVSLNYHMRNHTGKKPYGCEICSKMFTTKDELKMHMRIHTGETPYKCEICSKQFGHLSGFNYHMKVHTAEKPYECEICSKMFTTKGELKMHMRIHTGETPYKCEICSKQFGHLSGFNYHMKIHTGEKPYECEICSKPFTIKSHLNTHMKCHSRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSW3</accession>
    <name>A0ABM5JSW3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501031.1">
        <property type="nucleotide sequence ID" value="XM_050645074.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645074.1">
        <property type="protein sequence ID" value="XP_050501031.1"/>
        <property type="gene ID" value="LOC126880991"/>
    </dbReference>
    <dbReference type="GeneID" id="126880991"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF169">
        <property type="entry name" value="GH15759P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="323" mass="36355" checksum="4D6F6C3E44924526" modified="2025-10-08" version="1">FVGPPGVSIEDAYVQLFPVNKQKCREINPIRDITFYLFTRHNPLQPSQLRIGDDGALSQSYFNFSEPTVIFFHAFFESYQSTPGRLIRTAFLQRKDYNVLFVNAPRLEAGPWYLTAAQNTMVVGQYAAQFIDYLVSRGLYLPSLHLTGLSLGAQMAGVCGQSVQSGRIQRITGMDPAGPLFTKWPKNLKLDAGDAEFVDVIHTDAGIFGYPTSIGHVDFWPNQGISPQPGCTLPEIKRRNPDSFIIEPLFCSHWRSYQFFAESVVNPQAFANAVPCTSWKDYTAGRCRNFENGPPTRMGLYVDFEARGNYYLRTNPESPFSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT16</accession>
    <name>A0ABM5JT16_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DnaJ homolog subfamily C member 17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501079.1">
        <property type="nucleotide sequence ID" value="XM_050645122.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645122.1">
        <property type="protein sequence ID" value="XP_050501079.1"/>
        <property type="gene ID" value="LOC126881082"/>
    </dbReference>
    <dbReference type="GeneID" id="126881082"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12429">
        <property type="entry name" value="RRM_DNAJC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034254">
        <property type="entry name" value="DNAJC17_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="176"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32207" checksum="49DD763C9FF61DB1" modified="2025-10-08" version="1">MGDIKIEEMDLYEMLNIDIGSSISEIKKVYRKQALQCHPDKNPDDPNAAKKFHELSKALEILTDESARAAYDRVLKAKKEAALRHKELDSKRRKLKEDLEYREKQGSRQKSADELLKAEIERLRKEGSKQVQEEIEIVKQQLQKEKSNPQYWDGSKHRIKIKWSADKHDSNNGGYNQEMLTRFLSKYGDIQALVMSPKKKGSALVEFKDKAAAEMAVDLEVGLPHNPLKLEWLGGPPQKNLSGSSLVKESDFESITLTKLRQAEERKRLIEQMMAEDEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVT5</accession>
    <name>A0ABM5JVT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 4C1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502049.1">
        <property type="nucleotide sequence ID" value="XM_050646092.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646092.1">
        <property type="protein sequence ID" value="XP_050502049.1"/>
        <property type="gene ID" value="LOC126881685"/>
    </dbReference>
    <dbReference type="GeneID" id="126881685"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="57589" checksum="BBE4C1B614431287" modified="2025-10-08" version="1">MYILLLVLCVIAIFLFRWYTYHKYWKYVNKIPGPKALPIIGNNDLVNVDNEEIFRIFRERSKLFYPIYKIWSFEIYVIFLAGPPKDMELILGHSENNDKSFIYNFLNNWLGTGLLTSNGSKWHTRRKMLTPAFHFNILQKYLEVFNKETEILLDELDKDAGKEYINVLKPITDFTLFSIGESALGVSLREKNCDEYKKAIHEYVKIGEYRITKPFLYLDVIFNMLPISRTLKEYIKTLHDLSTNIIRERELGQQMDAEGNFSYSRRKRLALLDLILEARAAGEDIDEEGIREEVDTFMFEGHDTVSVALCYILLNLANEQDYQAKIYEEILSVLGTTQYPTQQQLGELRFMERFVKECLRLYPSVPLISRVTGKTLHTHSGYTIPKNSTVIMHIYDLHHDAEVWEDPERFDPDRFLPDNIAKRHPFAYLPFSAGGRNCIGQKFAMLEIKTVLCGILRKFKLEAVDKREDIKFIGDLVLRPAGEIRVKFSHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWD8</accession>
    <name>A0ABM5JWD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myrosinase 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502255.1">
        <property type="nucleotide sequence ID" value="XM_050646298.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646298.1">
        <property type="protein sequence ID" value="XP_050502255.1"/>
        <property type="gene ID" value="LOC114327593"/>
    </dbReference>
    <dbReference type="GeneID" id="114327593"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046848403" description="Myrosinase 1-like" evidence="5">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56590" checksum="2F854DE45FE892F6" modified="2025-10-08" version="1">MEYTFCLLFLWVGRSNGVYLTTSAKLPMYDFPKKFSFGVATSAFQIEGGWNASGKGVSIWDHLVHDTNEIIVDGSNADVACDSYNKVDYDILLLKALGVSHYRFSIAWTRILPNGFRNHVSEDGVKYYNYLINKLLENGIEPWVTIFHFDIPYGMFLIGGMFNEKFSEYLSDYADLLFNLYGDRVKTWVTINEPYSVCVSGTRVLGEYRPNGIVEYLCGHTFLKAHAAVYDLYQRKYKSQQNGKISMAFNLQCNYPETNSAEDIEAAERANQFALGWFVHPVVFGNYPQVMIDSIANISKTQGFLESRLPVLTAEDQKLLKGSFDFIGLNNYDTYLVSDDRKVDVDPSYINDQGVNFTYFPNWTVDYSIEMRSKGLGIILNWIKKTYNDPEIRILEQGFPETSTDLYDHNRHKYIVASLQQLWKSINEDNVNVTAYTFWSLMDNFEWDKGYSVRYGLNYVDFNDPNRIRIPRLSAITYNHVSTKKTLRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYE0</accession>
    <name>A0ABM5JYE0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502956.1">
        <property type="nucleotide sequence ID" value="XM_050646999.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646999.1">
        <property type="protein sequence ID" value="XP_050502956.1"/>
        <property type="gene ID" value="LOC126882179"/>
    </dbReference>
    <dbReference type="GeneID" id="126882179"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="785" mass="90761" checksum="A43B1D6F2D31943D" modified="2025-10-08" version="1">MNMNKIKHKYKFRSRTVKLVNEALSTECHSKPLDQSRSSNGSEYTPTCFSDDLDDSYEMHSISIETTDDSVANKQQTDCDLMYENDAILDDSTPNPIYQELIASSSLDNIEKSADETNSSLIDSVCLKKRRIRRKHNCIYCDIPVLNFARHLERIHSDELEVQKYLSLDKKDPKRKYFIDKIRKEGDFCIGKSVPVFRRNVLSNSDESSTNSNMLPCIHCKGYYAKKSLRRHIRRCYFNEKKATGKVRHQSEAQNLMATNFGSTDPLRTSGVLNSLAADDISLVAKKDKLICDVGRKYVKSHKDRHLIQVAKRQMRRLARLLIQSRKIENNSNLTLFFLLHPSKFKTIVSATRSIANYNTESKCFQSPSLALQMGTLIKKAISSAYSMEVQRDVDSANIKSLDVMKKLIDDQWALEISTEAGQNIQINRFNKPTLIPMAEDIAKMKTYLDELITSSITHLDENVNNTQAYKCLLEGTYCCLLLFNKRRVGELQRLPLDIYLKHHDSQSSKEFEKVLTETEKILVHSLKRIVIRGKRGRGVPVLFDKLTKSGVDTLIKYRNNFFTSYNEYLFGIPNTINCISGYHVLRKHASKVLNDANKITTLTSTRLRKHLATIIQILKMEKGELEQLAKFMGHTSKTHDEWYRLPSDIYQTAKVSKILLLAQNTNIDQYKNRNLNEIEVDNEILEDAEEADSDEENTNQPILQQNEVNIPSQNRIKEKGKRILVPWTKEEKELTQKFFARHIKKKIPPKKMEVLNLVEKYPNVFKNRKWDTIKVFVQNKYKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYM5</accession>
    <name>A0ABM5JYM5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503041.1">
        <property type="nucleotide sequence ID" value="XM_050647084.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647084.1">
        <property type="protein sequence ID" value="XP_050503041.1"/>
        <property type="gene ID" value="LOC126882258"/>
    </dbReference>
    <dbReference type="GeneID" id="126882258"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="327" mass="37065" checksum="7808EB73C34D4A57" modified="2025-10-08" version="1">MGIKFFVLCDSNGYAYRFEIYHGAGDNLIIPGTPDLGASSNVVIGLSQTIPNFRHHILYFKNFYTSLPLLIYLRARGIYSLGTVRANRIPNCKLPLDTDIAKEKRGYSIEYVGCSQGVDITTVLWNDNKPVRLMSSYVGIEPFARTNPNISQAKAPRYVRKEKTFVEVDVPQIIKEYNRRMGGVDSMDSIMGRYHIRAKTRDAMTRLFYHLVDMAATNAYFLYRRIQAERSNDSSDIDIGEEKLMDLPDFRDEIAAGLCACQDKRTVGRPSLVTNASQPSTSQIGRRAQHPVQDVRYDKIDHFTTWVSADKKESVNFAKSHKLSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYR8</accession>
    <name>A0ABM5JYR8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503079.1">
        <property type="nucleotide sequence ID" value="XM_050647122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503080.1">
        <property type="nucleotide sequence ID" value="XM_050647123.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647122.1">
        <property type="protein sequence ID" value="XP_050503079.1"/>
        <property type="gene ID" value="LOC114333623"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647123.1">
        <property type="protein sequence ID" value="XP_050503080.1"/>
        <property type="gene ID" value="LOC114333623"/>
    </dbReference>
    <dbReference type="GeneID" id="114333623"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="835"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="930"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="948"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130666" checksum="5DA7120435655DB2" modified="2025-10-08" version="1">MKWPKKLSWEGHLDSTDQNNNITMTSEDLLQPGHVVKERWKVVKKIGGGGFGEIYEGLDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHICRFIGCGRNDRFNYVVMQLQGRNLAELRRAQPRAAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSMGRLPYNCRKVYMLDFGLARQYTTATGEVRAPRAAAGFRGTVRYASINAHKNREMGRHDDLWSLFYMLVEFVNGQLPWRKVKDKEQVGLMKEKYDHRLLLKHLPSDLKQFLDHIQSLEYADKPDYQMLISLFERCMKRRGVKETDPYDWEKPSQTDNQVVTQQPVTGTTTQQATAPTTVPRHTRHTPTTDNNQENIEPTDNKEAQIDARRRIETENTAPLVTDTQINATRATVDKNCNATAVEQVQARKRRATSHLDQPPDRLDNDAVASAKSTSDAVKPAPLRKSQSGVATVGRLRVVTPAPATQVQTTASLVDSPATPEQERPRRRPPSAARSSRSGVRDQSLTQFAVMDDENVSQQMTRGGALTLASQWKSQFDDSEETTDNEWKPESPEHRGTLGAQSEAAAVLPPILSRISEDSRTSHRKYINIAGIEEYPELVGGLPRAWSTPCLGPCVRSSLKPPLLQQAAFDDLVFKVDVMRNVASKHVMSENDEEVKLADSHRYSSLPGINLPDVEVFRNDEEKPQEQNGEDEGLQEVAGKLEIRVVPKEQVNKDKVLRPQNLASKPPIQNGNSDIAAEHNNDVQTTNKESPQKPKIERTKSILKQSSKERSDPQELSSPKKENISFAPDVLDNKCDDVESSKPAESITVEVQTKEDCETQCNLEKNVELETRNPNSSFAETGLPPKTSDKIIGTEVPAAKAEGESSSTETDHKVPKEASHQDSLESYRKKKVHRKSSINLDQGDPLCRSNSLKAVSKPLEAVKNNLVDSKSSESSSSTQCRKQDGDDKGENKDRVRSSQGYDLGTNTNNVTFVSTTSIPEQREKRSIGSIANGLSPGMDEQSEYYDATENPIIKDKRQEQDDEDSGVDNASQILRETSVSPAMEGRLSKIPVAVSGQRLAKCMSWSGDLTPGLRRRRQNNDKYVTDPSQLKLRFKRHSSSGISPPLTNIVRTLRWMRDRTVTWFLCNFRSTGTRHLNVPHRRSGEFARVVRGTAPSAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ99</accession>
    <name>A0ABM5JZ99_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID 150 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503267.1">
        <property type="nucleotide sequence ID" value="XM_050647310.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647310.1">
        <property type="protein sequence ID" value="XP_050503267.1"/>
        <property type="gene ID" value="LOC114342650"/>
    </dbReference>
    <dbReference type="GeneID" id="114342650"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="278"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="530"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="649"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1187" mass="135600" checksum="04DA078E066AF187" modified="2025-10-08" version="1">MKKEKTGDNICAGECRPYKLAHQIVSLTGISFERKSIIGFVELTVVPLRDNLRIIKLNAKQCRIYRVILNDHYEAHFQYFDPFLDVCQSDTETRSLEAFSQQHLTAALRVDPDNNSGELIVTIPPEASHLVAEGTALRVGIEFSLECPQGGIHFVVPPKEGTYAERGVHLFTYGHQNSSRLWFPCVDSFAETCTWKLEFTVDEELTAVSNGDLLEVVYTPDMRRKTYHYTLNIPTCAPNISLAVGPFEIFVDPYMHEVTHFCLPNLLPLLKVTTRYMHEAFEFYEETLSNRYPYSCYKQVFVDETYDDYRSYATMSILSVNLLHSAVIVDQVYITRRVMAQAIAEQFFGCFISMQNWSDMWLNKGISQYLCGLYCKKSFGNNEYREWVQSNLFDVVKYEEDFGGIVLDPSQPPAPLPVGSNQPQTMQKTNEEKFYFSIRNLHTMSSMYIEALYKKAFLVMRMLEHRIGLELLLQVFNKQLSLATNAAQQKIGSGLWGHMLISTNVFTKAIFTVTGKDMAVFIDQWVRTGGHAKFHLTSVFNRKRNTIELEIRQDATSSLGIRKYVGPLLVTLQELDGTFKHSLQIENTVVKSDITCHSKSRRNKKKKIPLCTGEEVDMDLSAMDDSPVLWIRLDPEMTLLRSVVIEQPDYQWQYQLRHERDVTAQIEAIIALERYPTPPTRLALTDTIESEQCYYKVRCRAANCLTKVANAMVANWAGPPAMLAIFRKFFGSFAAPHIIRQNSFQNFQHYYLQKTIPLAMAGLRNTLGICPPEVVRFLLDLFKYNDNSKNRHSDNYYRAALVEALGNTITPVVSVVAQGTPITAESLSTETKLILEEITRLLNLEKALPCYKYTVSVACLKAIRKLQKFGHLPSRPTLFKSYAAYGHFIDVRLSAMECLADFVRADGKYEDLQYVLDFLENDPDPGLKHKLATLLIKNPPFKRAHRSKVDVPDLVERIWSNINGMLSHDTRLRCDLVDIYYTLYGTKRPVCLPIAELHDIMNPSKHDGSKKIKLPPIPKTVPQPTEQVKIRTPSPTIRESTSQTLIMETVDMDIEVVAGEEKIVIKEEEIMDIKIETSMVQKQEYFSDNSVSLPGLGQSGPIGFEPGMFKKEDEARHKSESPGKMKKKKKDKKKHKHKHKHKHEHKHKDKEKKEKDPNKLRLKEDTLSSMSSTPSPNPMSIGSAETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZU8</accession>
    <name>A0ABM5JZU8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503462.1">
        <property type="nucleotide sequence ID" value="XM_050647505.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647505.1">
        <property type="protein sequence ID" value="XP_050503462.1"/>
        <property type="gene ID" value="LOC126882538"/>
    </dbReference>
    <dbReference type="GeneID" id="126882538"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56103" checksum="36317800000D8CD5" modified="2025-10-08" version="1">MIESQLRSLETLGITADKYAAILYPLIESFLPEDMIRLWHRSSQFLRPSGSVSMHNVEESAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKYKSNNLVEKKNIKSPKQGTDQPSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKNCRARLNFILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTESIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLCELDIIGITDPVEKLTREVAAKETKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K057</accession>
    <name>A0ABM5K057_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503571.1">
        <property type="nucleotide sequence ID" value="XM_050647614.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647614.1">
        <property type="protein sequence ID" value="XP_050503571.1"/>
        <property type="gene ID" value="LOC126882639"/>
    </dbReference>
    <dbReference type="GeneID" id="126882639"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22824" checksum="4E39211A442172BA" modified="2025-10-08" version="1">MNTQMFVKWLREKLLPGLSEPSVIILYNAPYHSEILNKSPANSWNVDKIKEWLTNKRIYIPQLILKSELLRLAKEHAKPKIFLVVQVIESYGHQVLHLPPHHCQFNPIENIWGTAKQYYDNHIGPSGYTDEAVWETWREALSIATPEVWRNCISKCEKLIKDWWIRENKINEINPIIITINGDPSDEDDSVNNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0E4</accession>
    <name>A0ABM5K0E4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503654.1">
        <property type="nucleotide sequence ID" value="XM_050647697.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647697.1">
        <property type="protein sequence ID" value="XP_050503654.1"/>
        <property type="gene ID" value="LOC114325855"/>
    </dbReference>
    <dbReference type="GeneID" id="114325855"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF190">
        <property type="entry name" value="VITELLOGENIN-3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045271944" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="355"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="635" mass="71008" checksum="9B2E42D19F0108CD" modified="2025-10-08" version="1">MKALILQVVLYAIAINSTQLDKETPLDSQYVDITQTLRVLRITDEDVKIYFRNKQFPDNDIPLSPYNYEKLENDGFSAEKDTVLLIHGWKNSYKSTFNKLLSEAYLSKHDINILVIDWSSVADTWYYPSAVGEVESVGEVVGNFIKRLQTRLQLNLDKTSIVGHSLGAHVAGVAGRTVGGKINYIVGLDPASLGFNFFKRNSKLRPTDAKFVQILHTSLYGIAENMGHADYYANGFVGQPGCSWWEFKLCSHNIAYKYFGESIKSGGFKAQSCRSNSELIWSGCKGPESYMGQFDIDKTIRSMLFNQVNKFLSRMNNVLVLCAIFSCVATIPTSVFRDPSSELYKIQDLSQPIQLKKSVCNDDIKLYFRNQNGRDNENALDVNDTSSLQSLGFSTEKFTIFLIHGWRNEYDSDINTVLTEAYLSNYDVNVFVVDWSNLADDLYVNAASAVGGVGEIVGDYIQSLMKNNNLDLDRTAVIGHSLGAHVAGIVGLALRGKLDYIVGLDPALPLFLIVHDDFRLDATDAKFVQVIHTCAGFLGIDFNIGHSDYFPNGGRDQPGCWMDVVGTCAHGRSFRYFAESIKSGGFIARKCNNYNDFQYNNCSKESSNMGEYHIDKRASGAYYLDTNDDPPYAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K382</accession>
    <name>A0ABM5K382_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gustatory receptor 28b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050504649.1">
        <property type="nucleotide sequence ID" value="XM_050648692.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648692.1">
        <property type="protein sequence ID" value="XP_050504649.1"/>
        <property type="gene ID" value="LOC126883311"/>
    </dbReference>
    <dbReference type="GeneID" id="126883311"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9267" checksum="8AF825EDDFEC07EC" modified="2025-10-08" version="1">MSCDNAEKGAIRLAKLCSIMQADVKDPILIEELNELSKFIIELRPKFTVYGFFDVNQQTIPVFISALTTYLIILIQFKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K408</accession>
    <name>A0ABM5K408_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504928.1">
        <property type="nucleotide sequence ID" value="XM_050648971.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648971.1">
        <property type="protein sequence ID" value="XP_050504928.1"/>
        <property type="gene ID" value="LOC126883422"/>
    </dbReference>
    <dbReference type="GeneID" id="126883422"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="661" mass="75237" checksum="11AA0D3C23E97D00" modified="2025-10-08" version="1">MGQKKKNKKGGRESSGGEKENRRGGEKERDENQGEKRWRREVEEKEDPGSRTSANRSKGKEREGKRETREVREELQTKREEERKRIGREKEGEENRQKDEKNKAKSQRKENAREEGESSSSDSSSDDESEEEEQTPNCNARTKLERLQDSVAALEKLMVEVPNTRVAIKQEVDNLRNRLFDYTEELEESKKKEEVPRKSVCTTSRGVQTNMESLKVKKMATMGVQVDLENPEAIKRRVDAITEKMAICEYEEITEFLNEDWPEEVFQRTEVKEGDISDIAADVAVFVTNNDEDKKAMETVKGMFPDLPGVPAEVDEDGGLGTVRVTMSAHVDGTWIDKEKYGFKLLPNKKEELESVKFLKTCRKLVQKMEELGRERVGIHTPTSLGVETSRRILEWAARGRGVTITLLGKKSRRGWANINTKPREQCGVVLISKNKEKSFADLMTEVKSNLTGRKSIDIKRIRQTRNQGISLELGGGREMAEEVKKLLSGSTCVSRAVAKGGVVKRRILMQEIPPNTTEDVIQKAIEEAAGKERACDIVKTWTETRGGERGMMSAVMDVDEDAAEKILRMRRIRVEYTSCRVIEARTEIPRCLRCLAFGHKQWNCKGQNRRGCCFRCGKEGHIASECKTETITCLNCDVTGHVANSRRCPKFNRLVESRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4K1</accession>
    <name>A0ABM5K4K1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505114.1">
        <property type="nucleotide sequence ID" value="XM_050649157.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505115.1">
        <property type="nucleotide sequence ID" value="XM_050649158.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649157.1">
        <property type="protein sequence ID" value="XP_050505114.1"/>
        <property type="gene ID" value="LOC126883526"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649158.1">
        <property type="protein sequence ID" value="XP_050505115.1"/>
        <property type="gene ID" value="LOC126883526"/>
    </dbReference>
    <dbReference type="GeneID" id="126883526"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF106">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028456" description="Chitin-binding type-2 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="193" mass="21580" checksum="9C423FDF85948F48" modified="2025-10-08" version="1">MHSADLLFIAVLFVGSTTARDPDCDKHQYWPDVHDCSKYLECNPKGEKIEMSCPAGLWWNPLLTTCDNPENVDCKPVPNKSLGCTEGEYFPDTSNCQAFYECINGAKQRQLCPDPLLWNVHLPGCTTSSDCSQVVPTPTTCTEGDLTGDVDDCHRFFICKNDKWVGPLQCPNDLYWSEKAKGCVDIKDSDCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8X3</accession>
    <name>A0ABM5K8X3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506640.1">
        <property type="nucleotide sequence ID" value="XM_050650683.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650683.1">
        <property type="protein sequence ID" value="XP_050506640.1"/>
        <property type="gene ID" value="LOC126884623"/>
    </dbReference>
    <dbReference type="GeneID" id="126884623"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="280" mass="30743" checksum="21AB27FB40994F46" modified="2025-10-08" version="1">MENSDADDETGWNCSVHPSVFFLLGTLVLTTCATGMLCAAIMTDHWEEVTWDKNGVDFLANSSVRVQWLLDRTVARISTNERDRTIAFLVPMHGGIWTLCVSLSDEEINLLGRVGFPTVQSCVNYLSGGIDGVRGYEPRADWQHRMQNLSISCALVCLIILGSAALIGAFGVFQHQISAVLVTGVMYLLAASFALFTLTIIHFKRLHSRPHMDESEGTVDGVVSPTGGRGVKDLLPARVFTTSWSLDLGWGGVMLCVMTSVLWILLSKIMRFNPISSMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KB89</accession>
    <name>A0ABM5KB89_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507455.1">
        <property type="nucleotide sequence ID" value="XM_050651498.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651498.1">
        <property type="protein sequence ID" value="XP_050507455.1"/>
        <property type="gene ID" value="LOC126885068"/>
    </dbReference>
    <dbReference type="GeneID" id="126885068"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF399">
        <property type="entry name" value="CHITINASE 6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045199358" evidence="4">
        <location>
            <begin position="25"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="188"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="633"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="967" mass="109714" checksum="65A2A9313AC6A6C7" modified="2025-10-08" version="1">MKVKGVVFCLWFVFLGFPIATLESFPNSTSSTVRKRRQSSFNCTLPPQLENGRWLVTEADVKPGDQVIVNTIIRLECHEGYQLYPNIPLQLCDSNWDETTFPTCQKKCPSFYSTATTSVTCKDVNNAAVPCDKAVDGTYLTYNCNAYYEIPPGGRNILYCDDGVWDFPKPICQPICGKKVNTAIAAYAWGGREVKDFEFPWVVALYQTLGTSYENICGGTLISRRVVITAAHCVTNTYGKALDKNKFQVAAGKVYNAFGDKRDVNAQYRRISKLIVHEGYRGESQRYVADVAILITQELFKLDVVVQPACIDNMNNIYLTNYQIGEVAGWGRTEEEKPSEILKAIRIPYKDGATCAKELPQSWEEQFNFFDKICAGRQNESIAVCEGDSGSGLVFKNREDNRYYLQGIVSIAPNLNTFQCNSQTNALYTSVPFYYSFIKREMTKNHLEDCILPAYPKNGKWFLEGGIEKKPGDIVLSSTILRFSCNMRHILSSRSPYYDCQSFEDHPTCLRVCPKISLPAGSQILCKNFKDQYIDCNDIADGSSITFTCPNGFVSDRGTPTSTRYCRNGVYGNSAPSCTDIKQKSVYVSNTLYKSKPKIEHAPTTTTRSRITTPKSEITSKEPTPIPTIKNEIKMICYYARWMAYNGSHLEDFEPRLCTHLIYEHIGLSSSGELDLKESGLDLLQMTMDFKKKNKDLKVMINIGADESGNLFFNRLSTNNQIIEPFLSSVVKIMRTYSFDGLEIHWFTELSKKAIYINLLKQIKQRLEYHGWLLSVDVFPYLKDIGYDPKEMDRIVDWVTIRPRDLYTGARGYVDLNTSQPTFHRFHDGENGYDSKHIAESWLDAGLSKEKLIIGVEFYGVKYRQTDTLTTLEKEPVKYAEICSNFNTSDVVVVKDMKTEIVYLFNFTNSYWIGFYDENYIRSKGHYVKQNKLGGVAAFAIEFDDYKGTCGKTSPLILALLVGLGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCF7</accession>
    <name>A0ABM5KCF7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507865.1">
        <property type="nucleotide sequence ID" value="XM_050651908.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651908.1">
        <property type="protein sequence ID" value="XP_050507865.1"/>
        <property type="gene ID" value="LOC126885351"/>
    </dbReference>
    <dbReference type="GeneID" id="126885351"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1582"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1615"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1749"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1813"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1846"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="818"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2056" mass="236894" checksum="E0B9F4C41B2FB4E0" modified="2025-10-08" version="1">MEEKRPDQSFFKSIKQKYNQLKLRVKYGKIDFNPGEIKINTPLHKVAESGDRELTRLLLKLSPDAEASANRVNNDGDTPLHVAIKKMWQLKHRNCRNNDNVALLLIESGASVNCVDANDDTPLHAVIKQMWQLKYWHCRCYENLACLLIRSGASVNCRDANADTPLHAAIKQTLPQQPIRYIVAQELIMSGASVNCVNAKGDSPLHLAIRFFVLQFEYVPCGTINLLLGHMSDVNSTNNRGFTPLHEAVQAENVKMADWLIIESRNENFNDYEPYYTNISFRKYKRRVPFRMQSVYDDAGNKFLNRFFYSVESEDTTFLVDLVRMLLEAGANVNQQTAEGWTPLHFAVQRGLTDIVDILLQKGASVTLTAQNLPARILLKAPIKVMVKNGLMFKVVNDGYVNLYSGNTVLHQAAESDITDIAKLILDKGADINAQNSRGKTALHIAADNAKYHMVEFLILNGANLSIKDNYGLVPLENIYTGPYELVTAATKKYYDGDDDDDGFDDESYLGYRRELLKYIVLWQYNQEYLFVKNIHDEEYTISNCMPLITNFTIQFLWDKYEDTVDKMKDCIFEGSNISLYTILRHIFNDQLLAVYLRKKSVIQSLHSIDRYCAMFPEYEKVIEILPHKLKSAEERSSLLNKLIMEYNKVLPLEIVLQICSYLNNSDLKKFVVALCEASFTFKNLHEEGKIVKFVWVKAHCGIIHNEKVDMLAKEALDSDNFNKQAELGGEISKQVSSLKRDPGSRKNQQYIKERQDRLEDYWTRFGHNHEKLLDSGVTKDKYFETKYYEQVFKTYIEGKTLLEEYGRILKRGKTTKGKEIQIRKQKIEELLKEYEQELQYDEELQAELKEHMEKINTLIIEATVNDELDVIDSDEVERIDQLRRKVRETIKKMRPAMQRPDSTQRREGVTLPQVIHENEQLSRAEKMQYLKTQVRGEAHRMIQHLHISEANYEVAWNMLKERYENPRMILFKLIDRMLLAQEVKDSSARALKSLHDTFHECLETIGGLGTDTEAWSPLIARISITKWDNETRRLYENHSGDSREIPTFKSTQTFLQRRFQTLELLESEKRQEKQGGTVKKTRMGCVICNGDHGVPYCREFLELKVKDRNRIIREKEWCANCLAHKKEKQCFSQMRINEQMNKFNKALFTGLQEISKGINEVEDKALRLETEYSTLRIQTIALQVTEFINEYIQFYEGILNLHYNHGHFVDIIKPGQITKLIERAGKTLPQGVEIRRQPIIETEVSHDDKYIKVIGYFIVTGRNNYSMLKITAIPLKVEGSVLHSFVAPRNLLVVDYNTLHYFELTAEDKARCLQLARAQIACSPTAVMNMDTKPNCILEEIYERSKNSTCPVVTRAIHQAQWSKMGTPNLWLIITPIPIHLSIICDGNRNERVLERVSFLKLSPRCIARTKNITLLPTSSGVETAITSYLKTPITPVAQLLTMPRHLLNTIQPTHINTQGDEFRTILLDEESLEQEVAHTPWRKIHESHWTYLTATGVITSIVVIGLLILWRYCPGIRKCRSGKALRQTPDHENNCYQKVIKYMEQKRSDQSFFKFINQKYNRLKLLIQFRITDVNSRNIWNKTPLHFAVLPGDEELARLLIKSGASVNCVDTNGDTPLHWAVRFGSVDTVIQLLKHRSDVNSRNNNGFTPLHEAVYAETVKTSKCPLGSNAYLNVRIPRGLKYIYDNVGNEFLVTSAPTLHYIYDNAGNEFIKIYPCHLSILSTDTASTLVRILVEAGADVNQQTVEGWTPLHFAVQRSLIDVVDILLQNGASVILTAQNLPVLLRMPRKVRALYGICYKVVNDDNMHVDSGSTVLHQAAELPTTDIAKLILDKGADINAQNSRGKTALHIAVENSQRDMVKFLILNGANINKKDNHGKAPLGNSLDLLDFSFDKQIWIKYIVLWQKRQEYLFMKSSLIDSRMQTWWDHCEDTVNKMKDFSFEKSNISLYTILRNIFNDHQVAEYMQTKLINLSSPDWICIDIYCKRFPKYKEVIKIIPHKLKAAEQRNSLLDKLLSEFNGIMHQLPPEILLEICSYLNNYDFKNFVLAFSEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF10</accession>
    <name>A0ABM5KF10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508748.1">
        <property type="nucleotide sequence ID" value="XM_050652791.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652791.1">
        <property type="protein sequence ID" value="XP_050508748.1"/>
        <property type="gene ID" value="LOC126885961"/>
    </dbReference>
    <dbReference type="GeneID" id="126885961"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="206"/>
            <end position="233"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="234"/>
            <end position="261"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <end position="317"/>
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            <begin position="402"/>
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        <location>
            <begin position="486"/>
            <end position="513"/>
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        <location>
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        </location>
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        <location>
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            <end position="597"/>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="621" mass="73818" checksum="4241F8ACE5A1FA31" modified="2025-10-08" version="1">MELREDSIKREQNVLKSHKDGDSLEEEQHVNVQVKSEPEECMKFEIDYTQDSLSDWYRSDDIKIEHTSRPEISSPFPLIPKQDVKTEIKKELDDDEHSLGVNLGCETQFQSRNRKQLDSDKDVKLQIGVSTEIHPEKRGRRTKTSKLLSNIGKQRLHQNEIKKKSDRTLVTHTGEKRYKCEICFKQFTRVGNLKNHFRLHTGEKPYKCQICSKQFSEAGNLKQHLRLHTGEKPYKCEICSKQFNQEGNLKQHLRIHTGEMPYKCEICFKEFTRPGHLKSHLKLHTGEKPYKCEICFKQFGQQSSLKRHLIIHTREMRYKCEICSKKFNRDEHLKIHLRIHTGERPYKCEICFQQFSHASTLKIHLRIHTGETPYKCEICFKEFTRPGHLKSHLKLHTGEKPYKCEICFKQFGQQSSLKRHLIIHTREMRYKCEICSKKFNRDEHLKIHLRIHTGERPYKCEICFQQFSHASTLKIHLRIHTGEMPYKCQICSNQFRDSNHLKRHLRIHTGEKPYQCEICFKQFSEAGNLKKHLRWHTGEKPYKCQICSKQFRESSHLKTHLIIHTGERSYECEICFKQFGQQGSLKNHLRIHTGEKSDKCEICIKFNQEGHLKNHMKIHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFT9</accession>
    <name>A0ABM5KFT9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN-DOC-like zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509023.1">
        <property type="nucleotide sequence ID" value="XM_050653066.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653066.1">
        <property type="protein sequence ID" value="XP_050509023.1"/>
        <property type="gene ID" value="LOC126886205"/>
    </dbReference>
    <dbReference type="GeneID" id="126886205"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
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    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="563" mass="65022" checksum="0EB76BCC8DA42C43" modified="2025-10-08" version="1">MEKKRKIDSECRKFKDQWNIQYFVIESSNKALCLICNESIAVLKEYNMKRHYETKHSQNYSKYTGIVRTEKFEALKCGLKSQQSLFTKVKTEQEAATRASFRVALEIAKRGKPFTDGEMIKECIIAVVEEMCPEKVNLLKTVSMSANTVARRVQNIAENISSQLFDKNGHVEWFSLALDESTDVSDTAQVLIYIRGVDKSYEVHEELLDMYSIHGTTTGIDIFKGVEMAINKKNLRWKNLKCITTDGGKNMSGKDKGVVALVSKAVENDGGSKPLVLHCIIHQQSLCGKCLDMSDVLKPVISTVNFIRSFGLNHRQFRQFIAEIGETDLPYHTAVRWLSCGKVLQRFFELRAVIEIFLNEKHRPLTELQNNAWLWKLAFYVDLTKHVNELNLRLQGENQHLPDLYTNIKSFRMKLILFQSQLRSKCFSHFKTCEIFSHTTETEFPIDFAIETLSALKINFNTRFSDFDAIANQIKIFQNPFDADIETLAPELQMEMIDLQCSDIIKNKYENSSLLEFYKSLPLTQFDNLHKFARGLFSVFGTTYLCEKTFSKMKYKKMYTDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGP1</accession>
    <name>A0ABM5KGP1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509350.1">
        <property type="nucleotide sequence ID" value="XM_050653393.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050509350.1"/>
        <property type="gene ID" value="LOC126886451"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
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            <end position="238"/>
        </location>
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            <begin position="239"/>
            <end position="266"/>
        </location>
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        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="442" mass="52845" checksum="1EAA4C4D7042684C" modified="2025-10-08" version="1">MDVDVIQENCEETCKVEIEYNDLTDSAPLEGFKCEIKEENNSQHGTYDYLDLEEHRIKTKIVEKHENKLNTFEENQRSEKDFLQDNKMEIMEALIEHSSHKTNYMNLHAKEKTLTKHMEVVSGKRPYKCEICFKQFTRSSSLKTHLRIHTGEKPYKCEICFKRFNRSSDLKTHMRVHTGEKPYKCEICFKQFTTSSSLKTHLRIHTGEKPYKSEICFEQCSQKINLENHLIVHTEEKPYKCEICFKGFIRASDFKRHLRLHTGEKPHKCEICFKRFHQSSDLKTHMRVHTGEKPHKCEICFKRFNRSSDLKTHMRVHTGEKPYKCEICFKQFIQSSDLKKHLRVHTGEKPHKCEICFKRFNRSSDLKTHIRVHTGEKPYKCEICFKQFIQSRDLKRHMRVHTGEMPYKCETCFKQFSQKINLENHLIVHTEEKPYTPREKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIK8</accession>
    <name>A0ABM5KIK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PiggyBac transposable element-derived protein 4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510039.1">
        <property type="nucleotide sequence ID" value="XM_050654082.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654082.1">
        <property type="protein sequence ID" value="XP_050510039.1"/>
        <property type="gene ID" value="LOC126886921"/>
    </dbReference>
    <dbReference type="GeneID" id="126886921"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="118"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="1">
        <location>
            <begin position="534"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="67433" checksum="A68C241968A38191" modified="2025-10-08" version="1">MADLNKAGPSGVKRRKTVKVRNEKNLSVEELMQFLYNSDSDEDYEDSDVDNFEIENVSEDSSGSDTEDDVLQNELNNTVADNPDVQITDNEWTETTSGMKQIPFTKRSGLLVDSPGDSAYDWFRLLFDDELLNMIVLQTNSYAVEVLSTSKGCDRSRISLWKELTISELLIFIGLTFHTGTIQLPSIQDYWKKNRLFSTCFSSYMSRDRYLLIMRCLHFAENVKENEPVPVDRLYKVRPLLDHFNNKMKTVYYPGKYLSLDESMILWKGKLVFKQYLPKKRHKYGVKLYMLTEADSTILDIHIYAGAGDATAGKSHTERVVLHLMRNFFDHGHSLHMDNYYNSYNLAKLLLDKNSFCTGTLRKDRKGCPKNVVDAKLKKGQTKSMYLNNVMVGKWRDKRDIIYISTEYKNEIVTVRNRRGDEKIKPLPIIQYNKYMGGVDLQDQMSSYYPPTRKTLRWYKKIGIHLFQLYLQNAHRLYNKYHGNNKMSYYKFRLSILEKLLPEKCQGTAVVTAEVAVTSGVNHTPSKIELHNERGKTLRKKCRTCNKNKIRKDTIYHCQECPDKPGLCLGKCFREYHVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJK2</accession>
    <name>A0ABM5KJK2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510387.1">
        <property type="nucleotide sequence ID" value="XM_050654430.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654430.1">
        <property type="protein sequence ID" value="XP_050510387.1"/>
        <property type="gene ID" value="LOC126887095"/>
    </dbReference>
    <dbReference type="GeneID" id="126887095"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF235">
        <property type="entry name" value="CHITINASE-LIKE PROTEIN IDGF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046258598" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="452" mass="51432" checksum="B806558D2FDEF144" modified="2025-10-08" version="1">MAAGFKIFLLVLFSYVCYTQANPKVVCYYDEKGNSRQGQGKFDVAFLEPALQFCTHLIYGYAGIDPNTYKIKLMNEQLDLNQHNFRQVTDLKRKFPGLRVFLSVGGDRDVSGEDTEKNMVYRNVLEAVDRRLTFINSAKDLIKNYGFDGIDLAWEMPRTKPKKIFGTVKNFLVGIKRRIVGSSVVDDKADEHREQFTAFIREFKNALRHDGFWLTLSVLPNVNSTVYYDPRALAPHLDFVTLQNFDFYTPERNPKEADYSSPLYKIFDRKDDENGDFQVMYWLNNGMPANKILYGIRTFGRSWKMTQASGLTGVPPLTIEEAPGEAGPYTQEPGLLSYNEVCTKIANPTEIKAGYVGKLRKVNDPTKRMEIDYWNTTDVSKRFGTYAFREPKNGQEGIWVSFEDPDTAGQIGSYVKAKGIGGVSIVDLSLDDFRGLCTGDKYPILRAAKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KK33</accession>
    <name>A0ABM5KK33_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510566.1">
        <property type="nucleotide sequence ID" value="XM_050654609.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654609.1">
        <property type="protein sequence ID" value="XP_050510566.1"/>
        <property type="gene ID" value="LOC126887210"/>
    </dbReference>
    <dbReference type="GeneID" id="126887210"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="584" mass="67661" checksum="28C46099EC8EBDF8" modified="2025-10-08" version="1">MYKKTSISCLARNCCNNSGKSNISFFAFPKDVNRTKIWLTACGREDFLGKAENLNESYHLCGTHFDNEMFLNDMRNQLEPSAVPTNFPLLEGTSSGHFDHTYSTVVQNVYLPRCSINQDDSIYIESQPSTFLDLGDMRNESEDNSVMIVKDEIKEEIVEDDPRYIKSELSTSLDLGDLKNEPDDYNSAMTEKADDKDQFVKDGSGYIKSQPSTSHDLGNMRNESESNSVTVVKAEIKEEFVEDDPRYIKNQLTTSLDLEDLKNEPDDYNSGSAEEKNANETMKTISVPSSNKQQRTSRSVKENTLQCEICFKQLAYKSFLKDHMRVHTGEKPYKCEICSKQYTKASNLKTHLRLHTGEKPYKCDICFKLFSVAATLKQHKITHTEKKPYKCEICFKQWARKSELNVHNKIHTEENAYKCEICFKKFAHKYGLNRHLRLHTGEKPYKCELCFKQFSQEGHFSTHMRSHTGEKPYNCEICFKKFSVIHNLKYHMKTHTGEKPYKCEICFKQFSVKSNLKSHLRIHTGEKPHRCEICFHQFTTATNLTCHLRIHTGEKPYNCEICFTKFTRAAHLKRHMVLHAGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL86</accession>
    <name>A0ABM5KL86_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050510959.1">
        <property type="nucleotide sequence ID" value="XM_050655002.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510960.1">
        <property type="nucleotide sequence ID" value="XM_050655003.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655002.1">
        <property type="protein sequence ID" value="XP_050510959.1"/>
        <property type="gene ID" value="LOC126887460"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655003.1">
        <property type="protein sequence ID" value="XP_050510960.1"/>
        <property type="gene ID" value="LOC126887460"/>
    </dbReference>
    <dbReference type="GeneID" id="126887460"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="506" mass="58345" checksum="E287A00899241995" modified="2025-10-08" version="1">MAEQSLMSFMDELLESMCLFCAVCKDILKPPIMLVENVGNVCTKCYEEKQEVMNWKSMKNSALENILNLLKLPCKYKAKGCAVRVSYEDLDFHQSGCKYRTKVCSMLKFGCDWEGSTIDFIEHFKECHGDHVINFENNLFFLETSLNDTNMVKLLVMKQHTFILRMQTNLQKNKLFYIICSVDDDYSSFCEYSVKHKGGSENYIKTKSKIVSSYHIYNEFNENIAVEIDLDALKQISHISDTITNIFKIKLEESSGETIDDKILHFFECPVCKNFMKPPIFQCSSGHSICNMCRPRLEKCPTCRSAFGNTRNYSLEGLTAGVQYPCVYHDSGCLEIGSANHIVKHESECSFKPYNCPFPTCTSNGNHEVIVQHLINFHFDSVIYCGSTSYTDSFRLDQNNCYNKIFDRKCIITCNHIFRITCRRVAEHCLMAAEIVGSKNDLKTFIYEVSIIDMRRPEKKLIRTDYCLNEMPEDELFKKCIMFPNSVLSSYSNHGMVTFNVAIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLR7</accession>
    <name>A0ABM5KLR7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050511124.1">
        <property type="nucleotide sequence ID" value="XM_050655167.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511130.1">
        <property type="nucleotide sequence ID" value="XM_050655173.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511141.1">
        <property type="nucleotide sequence ID" value="XM_050655184.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655167.1">
        <property type="protein sequence ID" value="XP_050511124.1"/>
        <property type="gene ID" value="LOC114330275"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655173.1">
        <property type="protein sequence ID" value="XP_050511130.1"/>
        <property type="gene ID" value="LOC114330275"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655184.1">
        <property type="protein sequence ID" value="XP_050511141.1"/>
        <property type="gene ID" value="LOC114330275"/>
    </dbReference>
    <dbReference type="GeneID" id="114330275"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="13">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="323" mass="37590" checksum="482E02AA5DD98476" modified="2025-10-08" version="1">MASNETLEAFEKSLISKFECPVCLKFMQPPIRLCISGHIFCTYCFENIESCALCRAEKSPYRCIVLEQIYASLSFPCKYVDEGCIFSGKSDLLTIHEEYCGLSTVDCPLRYNNCIWTGFRSGMAEHCRADHTENIFFENEPKLKVANFNLRAGIEESILLCIHDTLFRGYWDLNEESGLMRFAVYYLGEPSCDKTFYFKITMFCTDSNEEVISMTGPCYPLKNDSFDNRFIGKKYLSTNFDMIKNLYNTNGDFNYSVGIIERNVVLPQIIETENKTENENEENENENRNENENRNENENRNENENEENENENRNEIENDSDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KN07</accession>
    <name>A0ABM5KN07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511581.1">
        <property type="nucleotide sequence ID" value="XM_050655624.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655624.1">
        <property type="protein sequence ID" value="XP_050511581.1"/>
        <property type="gene ID" value="LOC126887797"/>
    </dbReference>
    <dbReference type="GeneID" id="126887797"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="541" mass="63250" checksum="606AEC4C369DE336" modified="2025-10-08" version="1">MEFKVEIKDEPIEYNQKDNIESQLSTSIIDLEHFKNESEANFEMGEARVKEERADGSQGYNIESQLSTFPDPEDLINESDEDNSGFSQNGREIMETEVAGTTEQKKGASTPETTLKNSICKCKICFKQFNKAGFLERHIKTHTAEKIYKCEICFKQFTRASNLKSHLMTHTGKKPHKCEICFKQFIHANDLKTHLRVHTGEKPHKCEICFKQFTRARQLKLHLMTHTGEKPHKCEICFKQFIHANDLKTHLRVHTGEKLHKCEICFKQFTRARQLKLHLMTHTGEKPHKCEICFKQFIHPNDLKKHLRVHTGETPYKCEICFKQFSQTSNLKSHLMKHTGEKPHKCEICFKQFIHANDLKTHLRVHTGEKPHKCEICLKQFTQVSTLKSHLMTHTGEKPHKCEICFKQFIHANNLKKHLRVHTGETPYKCEICFKQFSRTSYLKKHLRVHTGEKPHKCGICFKQFTQAFTLKSHLMTHTGEKPHKCKICLKQFIRANALKTHLRVHTGDKPYNCEICFKLFKHKSSLDKHTRVHNRAGFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQD1</accession>
    <name>A0ABM5KQD1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512392.1">
        <property type="nucleotide sequence ID" value="XM_050656435.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656435.1">
        <property type="protein sequence ID" value="XP_050512392.1"/>
        <property type="gene ID" value="LOC126888303"/>
    </dbReference>
    <dbReference type="GeneID" id="126888303"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="398" mass="46305" checksum="74F6B40CCBF2EDE6" modified="2025-10-08" version="1">MCRGLINKNQHGFCSGRSTLTNLLPYQSKIIKALEEFKQVDAVYTDFSKAFDQVDHNIFLRRLFDIGFDVSAVGWIKSLLSERRQMVKIGAFKSDAICVTSGVPQGGHCSLMFFNLFVDSIFDCFADDFKAYRIMNCQTDQQLLQDDLDRLTQWRHINKLNLNKSKCCLISFFKGSRKYDTSYELCGQPLKTVSKIKDLGVIFDKNLTFVDHINSVTIQSSKMLGFIVRNCRHFSVDTVRSLYSSLVRSKLGYGSVVWSPYQAVHKYTVEKVQHKFLRFCGFKLYIGISDHNYSILEKQLDLKTLSERRICAGLYFLHKIVTGKIDSAELLESVNIEIVTRNRRHNYSSFHIPYHRTNYGMNLPIERYSRYVNQLHWEIFDMSESGFRAQFNRINFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS01</accession>
    <name>A0ABM5KS01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512970.1">
        <property type="nucleotide sequence ID" value="XM_050657013.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657013.1">
        <property type="protein sequence ID" value="XP_050512970.1"/>
        <property type="gene ID" value="LOC126888652"/>
    </dbReference>
    <dbReference type="GeneID" id="126888652"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="48299" checksum="D5187689FCD4EC5B" modified="2025-10-08" version="1">MYGKRAHSDSVVMPPIFDIYRKPIFDESIRKAEYRTYAPFIKSFNCNDIVEFSINQVDSFFAMSETLLCIKGSLEITGNGDVKLANNVGAFLFDSCTYSESAREMETVRDPGIVSAVRAMTCYTQEDSNYMVMAGWNYPKDPILNDTSFNIQMPLKHIFNIFNDYPMITCGRQTIRLVRARNDNDCIVIKEKQNADKTPTVTTAKINITNIELRVKHIFPNDEIKLELMKSIQQDKPIVIPFRKWELHELPAITKGARREVWAVKTSTSVERPRYVIVFFQTGKRNTITSDPTLFDNVSIQSIRLSLNGEYWPNERMQLDFSKTDYNEAYFNYTEFYPSYIHSQHKRTLLDFLAFKNRALFVIDCSKQEESMKASTVDVKLDIEASTGFPANTKAYCIIIHDCVMEYFPFTEIVKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS71</accession>
    <name>A0ABM5KS71_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513042.1">
        <property type="nucleotide sequence ID" value="XM_050657085.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657085.1">
        <property type="protein sequence ID" value="XP_050513042.1"/>
        <property type="gene ID" value="LOC126888705"/>
    </dbReference>
    <dbReference type="GeneID" id="126888705"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="272" mass="29868" checksum="0BB72749108B1ED5" modified="2025-10-08" version="1">MAEGIKVGIMPSEFPSQSLTTEQLEAVKELILDKILEHQREKSEKPNFLSAQNRPGWLALMCADKATLQWLKTHIGEIHPWEGATLRLVEGEEIPHTELFTTYLHGSKEYSTNKILGLIEAQNSLHTSSWRVINRSTSGAVEILTLSVDSQSAERLRTMGYTINYRYGRTVIRKKSGRNEATTSGSEKPTTSGSQKPATSGSQKPGTSGSQKPATISKAPDEQESAQATSTEGNESLEQIQAESRRTGNQRPDSKESAVDKKSGKPDKDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSJ8</accession>
    <name>A0ABM5KSJ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050513161.1">
        <property type="nucleotide sequence ID" value="XM_050657204.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657204.1">
        <property type="protein sequence ID" value="XP_050513161.1"/>
        <property type="gene ID" value="LOC114339782"/>
    </dbReference>
    <dbReference type="GeneID" id="114339782"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="910" mass="102834" checksum="195511DE13920D2A" modified="2025-10-08" version="1">MFYVLKLFRFSHLSLPTVNYSQYSNKKLFNLLKNMPKEPVHIHEAQKQRKKIKEKLSKYVPGKVTLQVLGTGAQGAPRALYMFSDQSRYLFNCGEGTQRLAHEHKMKLAKLEHIFVTQPVWNNIGGLPGIALTIQDVGVPEITLHGPPGLNEVFYATKRFVVLRDLKIHMAECTEDTGFDDNVMTVKYAPLVRNPNKMDESSTDSSEGECDSKVKDSEVEAVADQADASTSTRSERSRKKRRNSKDSKNNSRASSIDAYEDNTDYYAYESKICGKFKNNKRNRSRSHSSSIESGTRVLNNAPQPHPMLESTKEQGISMAYVCKLQPRPGALNLEKCVQMGIKPGPVFGKLKNGEDVTLPNGTVVRSADVCEPDDPGLVFIVLDCPTVDYLDSLENSQIITNHQKYNKDETQIASLIVHFTPKDVVENPRYKAWMEHFPASTTHLMLNEYNTCMGSEAVHRIQYKLNLLSNDIFPLLGEKGTLLPKGEVEGESDRKKQKMEDLVEDLENNLNTAKLSESPSLYITPDTFCAYHLRPKRGLDRSLELRLNPTEYLEETYNVADFKTVLETLKSNLNSKTVSRDEFPKIIFLGTGSCIPNKTRNTSGILLALNENQNIIMDCGEGTYGQLIRFFGPELSSQVLANIDAIYVSHLHADHHIGLIGLLQGRKRAIRQLKAKKSPVVLFAPKQIMAWLNFYDRCFENIRSEFELVGNSDLDINNPVSTNQIKSSILSRLNLQDINTCLVKHCPNAFGVSLTCKNDIKITYSGDTMPSENLVQLGHNSDILIHEATMEDELEQEAVIKMHSTTSQAIEVGNKMLAKNIILTHFSQRYAKLPRFNDNFSSNVGIAFDNMQVSLSDLPLIPELYPALRLMFAEHYEELENKAVKRQLRIEREKEKKTVDNNLKRKQVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KU84</accession>
    <name>A0ABM5KU84_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513702.1">
        <property type="nucleotide sequence ID" value="XM_050657745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513750.1">
        <property type="nucleotide sequence ID" value="XM_050657793.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657745.1">
        <property type="protein sequence ID" value="XP_050513702.1"/>
        <property type="gene ID" value="LOC126889440"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657793.1">
        <property type="protein sequence ID" value="XP_050513750.1"/>
        <property type="gene ID" value="LOC126889472"/>
    </dbReference>
    <dbReference type="GeneID" id="126889440"/>
    <dbReference type="GeneID" id="126889472"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63048" checksum="3A9A8BC0F1938FE5" modified="2025-10-08" version="1">MENRSKKILELALDENNKKKDYSNANKMGKSYFGPPSKTKQNAKKKTELLEPNVKILSNVNLKEKIDNYLQTITTPFFFECQENKIDESTLSESKNNVETPFNKYDKEKKQDHLKPKANILLEPDVKLNDNTDNDSQPLNKTLDLYEFQENDLEEKASKSPEYDKLEEKTYTPLKAVNFDCYPILTKIDTNLNTDHRDYEDNEDFSESRDTSSYVPETEIESEGGEEETIIPIFKTINVTCPESTLTKDEPSEKPHISNIETNNSIVALSHRKNRVWDRKNFCPICFVEVSHFARHLERNHADESRVKKILSFPKGSNERKTLWDYLRKEGNFHLFREEKKVVAVRRPTEAQALDFDDFVVCENCSGVYKKNFFYKHAKKCQEKHTGTKCGRLNALTQSQTFLAASRCQNSFLSQSRLKKEVFCIMKADKISATAKNDILICLFGETHLKKHKRKQIVTVTSNKMRELARLLIALREFTPVQNLIDAMKPELFDDLVTATKVISGFSNADKSFKSSSLALHMGTTLKQVCDIINRMILKKIPIIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUI4</accession>
    <name>A0ABM5KUI4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513105.1">
        <property type="nucleotide sequence ID" value="XM_050657148.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513847.1">
        <property type="nucleotide sequence ID" value="XM_050657890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513848.1">
        <property type="nucleotide sequence ID" value="XM_050657891.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657148.1">
        <property type="protein sequence ID" value="XP_050513105.1"/>
        <property type="gene ID" value="LOC126888764"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657890.1">
        <property type="protein sequence ID" value="XP_050513847.1"/>
        <property type="gene ID" value="LOC126889537"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657891.1">
        <property type="protein sequence ID" value="XP_050513848.1"/>
        <property type="gene ID" value="LOC126889537"/>
    </dbReference>
    <dbReference type="GeneID" id="126888764"/>
    <dbReference type="GeneID" id="126889537"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="160" mass="17647" checksum="663039B96FBFB57F" modified="2025-10-08" version="1">METLSPSKICGRRIVDVCHFSKALLSFPHCGLFSCDGTTVELLKETRKGLESTFLFQCNTCKSTVEVSTDDPYSKQTPVNTAAVTGVISIGLGYANLKEWCSTLNMPVMSETIYKKIEGKLMDNFYTTATELMLAAGKEEESLAREWGEVDPEDDKAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUR5</accession>
    <name>A0ABM5KUR5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513931.1">
        <property type="nucleotide sequence ID" value="XM_050657974.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657974.1">
        <property type="protein sequence ID" value="XP_050513931.1"/>
        <property type="gene ID" value="LOC114337614"/>
    </dbReference>
    <dbReference type="GeneID" id="114337614"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="277" mass="31771" checksum="F697C3E9E22FBE40" modified="2025-10-08" version="1">MFGKPPKIDETIKFCNRLAIVATIFFFQCVFLYETAALYGSRSCLKLAEEKGLHINCLTMFPVWLPFEADVSTQLIISFVQFMLILYCVIPVGAACLLPWEVSQQLTIHIHHLNNMFNNIFETDNKEEQRRRLSIWIKYNLRIIRITCKLNRLTKGCVGIVSLVVSIVLALTANQLMSWNRPLAAFMHISGWLCSLTANCITGQQIINQTQCITKNIVCSKWYTADLRVKKDILFVLLNSQRSFRLTALPFGTLNMELLLLIIKSSYSYMTLLKNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWB9</accession>
    <name>A0ABM5KWB9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514487.1">
        <property type="nucleotide sequence ID" value="XM_050658530.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514489.1">
        <property type="nucleotide sequence ID" value="XM_050658532.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658530.1">
        <property type="protein sequence ID" value="XP_050514487.1"/>
        <property type="gene ID" value="LOC126889846"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658532.1">
        <property type="protein sequence ID" value="XP_050514489.1"/>
        <property type="gene ID" value="LOC126889846"/>
    </dbReference>
    <dbReference type="GeneID" id="126889846"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF457">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="56053" checksum="3C91C70EAF46C5B8" modified="2025-10-08" version="1">MVKEVRALGSPCGKVMSARYVLAILGSVGLGIIYGLKVNLHVAIVSMVKHGPSNSTQNQNVTNNLTRPAETCGEEDITNSTTITAEQGPFDWSTSVQGLLLSAYFWGYIVAQIPGGRIAELFSAKWVMFFSVAINAVCTLLTPVMANLHFGALIAMRIGEGIGGGVTFPSMHVMLAHWAPPNERSVMSSIVYAGTALGTVVFMLISGIIAGNIGWEAVFYIEGGISILWLLLWGVFIADTPKSQRFISEDERKFIESSLNHGSESKQETKYQMPWKSVLTSPAFLAILVAHTCSNWGWYMVLIELPMYMKNVLRFKISENAILTALPFLCMWLFSMILSKTLDTLRARKIITTTIARKTATGCASIVPMICFIALSYISCQRAVAVVLMTIAIMSIGGMFCGFLSNHIDIAPNFAGTLMALTNTVATIPGIIVPVFVGKLTEHDESIKSWRIIFWTTVGLYIVEILVYMIFGSGEEQSWNKVEDEANETQPLKPKKEELKKKLSATEKSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX14</accession>
    <name>A0ABM5KX14_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514727.1">
        <property type="nucleotide sequence ID" value="XM_050658770.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658770.1">
        <property type="protein sequence ID" value="XP_050514727.1"/>
        <property type="gene ID" value="LOC114324271"/>
    </dbReference>
    <dbReference type="GeneID" id="114324271"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21227">
        <property type="entry name" value="CH_jitterbug-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21229">
        <property type="entry name" value="CH_jitterbug-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21185">
        <property type="entry name" value="CH_jitterbug-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF13">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="34"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="362"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="445"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="541"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="905"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1442"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1548"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1630"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1715"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1804"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2085"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2167"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2262"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2349"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2446"/>
            <end position="2535"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2536"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="2630"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2740" mass="295978" checksum="0A8EE33BBB9C3803" modified="2025-10-08" version="1">MEGKISHSGLLARSPEGHAARGMQIKGNEDLWVDIQANTFRNWVNEHLPQDLRVADLSKDLCTGVRLCLLVEALRKKPLKPSWNKRPANQHHYLENVTCALSAIEQDGIKLVNIGNTDIVNGNLKLILGLIWSLIVHYQIGRSKFPPRKLMLSWLQAVLPECKVSNLTTDWNSGVLLSALVDYCRPGLFPHWRQLDRSNEIENCRRAMNIAQKDLGIPAVLEPEYLASPWLDELSGMTYLSYFMKPGSPGFYATLRWVNSRLERSINNFTTDWNDGRVISEVIRSLGGSAAAPEKLRSDYAYWEQNQIQAIEAGRRLGVQPVLSAKDMADRNVEHLGVMAYAAHFQWVPERPPLHDLINVTLNSTSGRVGEPTYYQVTLLDSSLSYSKLSTEIRGPDNKIYLGSKLQQGKGNFVPSKVGMHEIIVKYEGEEVQAGHYFRVLPPLVEVAPPGMAPCALGSLVQVLVNATGAPRREDILVTAYSPSGRPLDCPLTVIDGTNSATFKPDEPGEWRIEITYQGKQIQGGPFTCSVFDPNGVQVSGIEGALPLIPHAIEVDCRGVGVPGEVVADIVHDKKSVHCHVEKIDNFHYRIHFTPKDAGKHRVYVYFNGYDVKGSPFMMRVGTQKRSKISSSPTSPYRASPTNRFNSPSPNLSTPTKNSSYTSYRQNASPLLDETHKFAQDYHMKSVSEKRMPSSSPIYQDRTHSPSYNQRTHSPVYRTASPNFHPPSPNYRPNSPPVQGRDSPDFITSRKLNEKRYDFTNKMSSMRLEDSRSPSYLERSSPDVGFTSTSRYDKRVSENRVFTNSSNGVDTTPIIKVSSLNDQSSARRDSWDAIAKTKNILSDRSLESLANLTESQLDTDIRRRKAEEHSKFVLKEQSYQTNYNENYSSSKKYSDSFGRNSPVYSRVRKDGGASSVKVQPVPDGVLGQPVEFEIDGSGAGSGDLEILVEGGRVTSSVKSLGGQRFRAAFTPHQALPHRVDIRFNGETVPGSPWHVNIMSNNSALSVLGEATRLVPANSPAVFEIITPSSTPPSDLRVHVVAPSKRVVSARVIPGNRLGVHSVEFVPTEIGTHLIDVSVDGEKLPSGPLMAKVYDAGLIQVADVGGGVVGQPVQFRVDASQAGEGQLEISINEGEVPNHVQVVGGGRCLVSFTPDQAKPHLIDIKFNGETVRGCPFVCAVSDTSRVTLSLSHLELIPVNQPSSFHMGVAGGGAAELAVAVRGPVGELPVKVTGDIHSGFTAEFTPTQVGAHQISVDYNGRPVQGTPFIAKSFDSNKVTVGTVARGTVGRPVTFSVDASEAGEGNLEITISARGLNIPTQVHPQGNARFAVSFVPAEACDHVVNVAFNKRPVVGCPLIVNVGGSGTGPSVTLPGPGPVHRPSTLLINHPGRLEDIEVNVEGPGGQAVPTQVQPLGNGQFRAEFVPRVVGEHRVNVSVSGVPTVGSPYAAKVYDVQAIKIKEAASGIVGKPVTFLVETSQAGPGNLEVTVNGGLVPTSAQAQGPHTYAISFTPREATVHSVDLRFNGQDVPGSPFKCAVSPAARILSLDTLDKVSVGKPCTFVVESPNPPTVEILGPARRALVTKVRPQENTVGKFEVTFTPIDVGDHSVEVRLQSGHIDGSPFLIKAYDANRVTVTDITDGIVGKPVSFSINASQAGAGNLEIIVAVGGRNVPNFVQSEGNARFKVNFKPTEAATHTLSVRFNGQPVPGSPFNCKVSPGNTQPRVPVSGSGIELAAVGHPAEIKIEGVTGGEPQVLATAPNGKTIPTKLIVNGDTYIARFIPESVGRHSIAILINDQHVIGSPFSCNVYDVNKVIVTGLPERKGDLNTSINELSLKDAPKPAEVGKPVTFSVDAAQAGEGTLELVVSTQHTTIKAEVVACARGLYDVTFVPLTAEDHYVNITFNDMTVVGSPFHCSVIESTQYFQIGATAYIDLPSDNHKIEISDPNNHHVKYVVNNYKGEFSLTQTGTYRVNILRDNEVVATRTFHVFDTTKIDIINAPEAICHRPSAIGINMNRVGPGKLTAAVKVGNRDVSHSVRQSPTNANMWEVIFHPVQAAPHRITLFYNGVPKFGVLEIPVKGPGSEPWAGGLGLYQAKVGKVNSFQIETQGRSAREFDVVVSGPTGSAVPVRCYQTKTGKLQAEFTSREIGAHKVEVLHQGKHLVGSPFVCQAFDPDNVKITDVPTSQGNVGDKVYFNISTKSSGSAELDVQVTNPIHQTLAVQKVQSDENTTQVMFLPALAGLYQVAITYGGIPVKGSPLALGVGPVGPTPPPRAVGKGLEFGRVGERSSFTVSSVVQPRVSVEAVEGNIDVQVQSHKPGEYQVSYVPKWVGTYDVIISIGPNDLPGSPFRPSVVDPAAVRLIGGWNQYLDDTGRIKLPAKLAFDTSNAGPGNLECKISGRKVNQEKSNTRIRFELSGEGLSPGEHEFDIRFANYPLPEAPSSIICLGDQVVLTGRGLAHAQCGDAATFTIDGSKASIGNPEVTLHAADNNIPVPVMISLAGDKIWKAAYTVSIPGNYLLSVLWAGRPVKGCPLVVEAKGGADASKVLCSGEGLRQGVVGREIRSWIDTRRAGPGELTAHCAGPRKVAYCELYDHGDATFTLNVKPQEPGRHALTIKYAGQHVPGSPFTLRVAGAPDASKVRVYGPGIEHGVLATFQSRFICDTRGAGAGQLTVRVRGPKGAFRVEMQRESQKDRTILCKYDPTEPGDYRVEVKWAGELVPGSPFHVMIFDTQEELRRYINTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX91</accession>
    <name>A0ABM5KX91_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514797.1">
        <property type="nucleotide sequence ID" value="XM_050658840.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658840.1">
        <property type="protein sequence ID" value="XP_050514797.1"/>
        <property type="gene ID" value="LOC114338199"/>
    </dbReference>
    <dbReference type="GeneID" id="114338199"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027993">
        <property type="entry name" value="DUF4495"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33960:SF1">
        <property type="entry name" value="SIMILAR TO KIAA0825 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14906">
        <property type="entry name" value="DUF4495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="829" mass="93999" checksum="7B1691D45889804D" modified="2025-10-08" version="1">MEVMEDGNLMDKVNILIQRDMEYYDTNQSILQETICAGVIGGKLDFPRSASFASMKLVIWWEEEFVAAYKKSSEFLPKIKKADKQADDDSEGIVKDSDPSKFVSLIAKSADQLLAHLHILTQEALDHADLTVLTGTIGASALLKNCLWFYIKIIKEDKKCNIEEIQSSYKKYHEMCEALAERLLDLHCRLVSLYILQDAECLDWESEKPFFESERGSYIIQMWWLYMQGTKDDLWNTVPPKMAQRVFAGMLNESLTILTVRYTQSVPSEIRSQLIVVDISNLLVCVANLLPAICNNAKDLVGVSYSSSSKILRDIHTKCQELYTCLLLRGAPIDLLHKVFRRGIDVVEMFKSRSAGDAPWITFALPNMFDDKLKPGSKTNNNPDTDIALELVVMLAQPQPNWALLLKILCMNKYRILQLALKATSSQFKEKMEKPVCKNTKCTAFLCNEEGSCKDDNTSSTYLQQIHYYNIILSSTEILLFVGNKQELTDILLPIIILQPDWCHSLERRHVWNQIRPPWYEAILNFSSPIIPLATDTVINAIQTGATMYQAMSLILACFSHFWDCVNPALYRVSCILQESILTDIVPLNNSTLVQILVSALYSHLLKKSQEVKKEVRIDENTEPTSSRQLSVVSVGTDNVNSSPEAIALATAECLCSIDEDNKHTNQIEEFLEHIKLNSKFAEGEGNISSRLEANQHFAEVVVSEILGTSSGRNSLKTIYWFIKCNSDYFYKQLGVSTEPEEIEPKRALVKPISLLHTMFNIGSQSFDQLLSGNWHPNWLSLLQNARGLSADRVWKQLSLRWEFRNVNATAIPPHISQMIGNITAIFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYG4</accession>
    <name>A0ABM5KYG4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515225.1">
        <property type="nucleotide sequence ID" value="XM_050659268.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659268.1">
        <property type="protein sequence ID" value="XP_050515225.1"/>
        <property type="gene ID" value="LOC126890384"/>
    </dbReference>
    <dbReference type="GeneID" id="126890384"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038899">
        <property type="entry name" value="METTL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108:SF0">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36690" checksum="5C3FCBB6A91A158C" modified="2025-10-08" version="1">MEGHSSLFTCTKLWSCILYRLLLLTVGKYSHILICQVVQRFKMDDEVSSEIYQENNYFTRKKPTFDDKNVVSKFNFVLPQRWPGLMSVDADGDLNVLRRNSASPTESIEIEHKQSTIIDMVGLQIWRGALLLADWLIYNHEEIPKDSVILELGSGVGLTSVVASMYFPVICTDVNRGNILGLIESNVTRNKNLSRHAVRVLELDFLSPDIPGEILEQLPNISVIIAADTVYDDTITEAFVRTVHRLVTFSPSPAGKRSVYIALEKRFVFTLSECDTVAPCYEYYLKCLDKLTGVKCEEVSLAFPKSFEYDRVKELVLWKVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYL6</accession>
    <name>A0ABM5KYL6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Very low-density lipoprotein receptor-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515284.1">
        <property type="nucleotide sequence ID" value="XM_050659327.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659327.1">
        <property type="protein sequence ID" value="XP_050515284.1"/>
        <property type="gene ID" value="LOC126890419"/>
    </dbReference>
    <dbReference type="GeneID" id="126890419"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046766697" description="Very low-density lipoprotein receptor-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18809" checksum="3C8D702543850DCB" modified="2025-10-08" version="1">MLIVFFVISTLLNAVISTNYYDCPQHQFTCTNSKCVDFQQRCDGSDNCGDGSDELNCDHKCVEHFFNCRNGRCISEAFLCDGENDCNNFLDERDCKDQTITVAADQCGDGNWQCTDRLCIPNDWVCNGVPECFDGSDETTGCSSNTVCEEFKCKNGHCIPNEWHCDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYR4</accession>
    <name>A0ABM5KYR4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 6k1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515322.1">
        <property type="nucleotide sequence ID" value="XM_050659365.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659365.1">
        <property type="protein sequence ID" value="XP_050515322.1"/>
        <property type="gene ID" value="LOC126890435"/>
    </dbReference>
    <dbReference type="GeneID" id="126890435"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="57337" checksum="72F4FA4F5F7F2FA7" modified="2025-10-08" version="1">MLLTSSWITDTTILIALIGLLIYKYLTRHFDYWEKRNVPYLKPTLLFGNFKDVFTCKLTIQEHLKNLYDKIDAPYFGVFLMDEPLLILKDPKLFKDVLIKDADVFANRRPPTPTHRLMENSVIFMKYPHWKSVRTRLTPVFTPVMLKNMHVEISEITKSMVQYLFKNKKTIDGRGLGKLFSDELIFKCFFGVNLDSFNEKPTPIGSLVKKMNEFSLRNALVQNLSFIKPSWATLLKLDFFSDSSLRFFEDIFKKGMEARNHYDGKPLNYVDFANKGVRELGEGMNASKEMDMSVAGAILFLIAGRDTLNTLLSFTLYELALHESVQTRLRQEIQENIKKYGGITYEGMQDNKYLDMCIKESMRKYPPIPFVDRVPISDYQFEGSGLKLESDKMTVVIPFLAIHRDEKYFPNPESYDPERFAEETVSEGLIYFPFGEGPRACIGRRLAMLSLSIGLSYVLMNFEIERSPETPTKIEFEPKSFPLISKVGLPIKITPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZV6</accession>
    <name>A0ABM5KZV6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515720.1">
        <property type="nucleotide sequence ID" value="XM_050659763.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659763.1">
        <property type="protein sequence ID" value="XP_050515720.1"/>
        <property type="gene ID" value="LOC126890650"/>
    </dbReference>
    <dbReference type="GeneID" id="126890650"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="171" mass="19981" checksum="F61AE2A55DD37986" modified="2025-10-08" version="1">MKINDLTHFSACFEINQEDFSRFAKVLTEIKRELDERFSEFDALKPDLELFNNPMGVNIQNQSAEYQLELCELQSDSFFQAKKNEGISTFWKLVSKDRFPKLRNFALKLYSMFGSTYICESTFSALKHIKCEIRNRMENDSLEACIRLTTTGIDTDVQKLVEDIRLPQISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0R1</accession>
    <name>A0ABM5L0R1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516025.1">
        <property type="nucleotide sequence ID" value="XM_050660068.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660068.1">
        <property type="protein sequence ID" value="XP_050516025.1"/>
        <property type="gene ID" value="LOC126890904"/>
    </dbReference>
    <dbReference type="GeneID" id="126890904"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022242">
        <property type="entry name" value="TNP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12596">
        <property type="entry name" value="Tnp_P_element_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="945"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1043" mass="120390" checksum="845F84B1C76DBCBD" modified="2025-10-08" version="1">QLVIANDTDSSLKNIVCGVPQGSVLGPLLFLIFINDITSLKIDGKIFLFADDTSITWSNSNIATLHATITSDLLTIKTWSDSNLLSFNVDKTVALSYKGVLQPLPLNNSQISTVDSVKFIGIFLDSNLKWSHHIDLLRKKLSSACYAIRSVSNELNLASSKITYFFFVRVTSSLWSSFLGFWYSCPIRCYFQITKKSNCLKIFRINKNIFSDLSDDAEKEEVDADVEELNQLQYDALEYVSGYICKKLDLPESTDTSTYTWIDQVSEGGLKKPPEELVVKMHQLDTIFNNFNGSGLQLKSGKKYLQRLIDLSKKIECASCEDIQNDECNAILKYPGNNLNQNLTATTDVNIGEKYFECEICSKQLTSFSLKEHMTAHTGENPFTCEICTTEFSLKNHLTKHMKLHTGGKLFECEICTKQFSTKQVLKWHIKVHTGEKPFECEICTKQFPTNAHLTRHMRVHTGEKPFECGICTKQFSMKQDLKCHMRVHTGEKPFECEICTKQFSTKQHLISHIRVHTGEKPFECEICTKQFSTKQVLKWHMRVHTGEKPFECGICTKQFSMKQALKCHMRVHTGEKPFECEICTKQFSTKQHLISHIRVHTGEKPFECEICTKQFSTKQVLKWHMRVHTGEKPFECGICTKQFSMKKALKCHIMRVHTGEKPFTCEICTTEFSLKNHLTKHMKLHTGENPFECEICTKQFPTNARLTRHMRVHTGENAFECEICTKQFPTNAHLTRHMRVHTGEKPFECGICTKQFSMKQALKCHMRVHTGEKPFECEICTKQFSTKQHLISHIRVHTGEKPFECEICTKQFSTKQVLKWHMRVHTGEKPFECGICTKQFSMKKALKCHIMRVHTGEKPFTCEICTTEFSLKNHLTKHMKLHTGENPFECEICTKQFPTNARLTRHMRVHTGEKPFKCEICTKQFSVKVNLKSHMRVHTGEKPFECEICTKQLSTKQALKWHLTVHTGEKPFECEICTKQFSKKQVLKWHMRVHTGENPFECEICTKQFPTNAHLTRHMRVHTGEKPFECGICTKQFSMKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L133</accession>
    <name>A0ABM5L133_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516149.1">
        <property type="nucleotide sequence ID" value="XM_050660192.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660192.1">
        <property type="protein sequence ID" value="XP_050516149.1"/>
        <property type="gene ID" value="LOC126891012"/>
    </dbReference>
    <dbReference type="GeneID" id="126891012"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="227" mass="27023" checksum="F7EFC9745A36579A" modified="2025-10-08" version="1">MSNKRDKPKHENSFDEEEVFKRSKSTTRTPPKDNKEEQEKQEMEDIKKMLKEMNEDIKTQIKELKTELKEENEEIRNNIREERKELKQENKMLKAENKKITEDLSDLKRSMERLDKEKRKNNLIISGLIIDSEDPIALKQEMTNMLENHPGRIKTDVKRAQKIGTETCLVELGNEEEKVAILRNKSKLKKVKHRKICITEDLTKRDQQKAKALRDISREMREKVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1F2</accession>
    <name>A0ABM5L1F2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516266.1">
        <property type="nucleotide sequence ID" value="XM_050660309.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660309.1">
        <property type="protein sequence ID" value="XP_050516266.1"/>
        <property type="gene ID" value="LOC126891128"/>
    </dbReference>
    <dbReference type="GeneID" id="126891128"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="79"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="46795" checksum="92B224501AC2B96F" modified="2025-10-08" version="1">MNGSILNVNKTVPVDESIINSEYHTHLPYSATSLDNNDEIRIPIQSQNIYTYPSESYIILEGNLISQEKGHYSTKLSFINNGFLHLFEECRYELGGTIIARSRFPGITSTLKGYASFTPNDCIKNANSGWSITEDPKIVEPTTGYFNVCIPLKQILGFGEDFKKIIINLQQELVLVRSHTDFNATITTDGATDTPKVKITKIMWKVPHISVSDEQKLVLLQHLEMQNNLEISFRNWSLQKLPVLPKTKSYDWTIMTVKQSEVPRYMIVGFQTDRENSKTRDNSDFDHCNLTNLKVYLNSEVYPYDNLNIDFKKKHYAIAYEMYARFQESYYFQGKSEPCLSLTNFIQKAPIFIIDCSHQNEAVKGGAIDVRLELESSENFPDNTSVYCLIIHDRTVIYNPLSNLVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L228</accession>
    <name>A0ABM5L228_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516494.1">
        <property type="nucleotide sequence ID" value="XM_050660537.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660537.1">
        <property type="protein sequence ID" value="XP_050516494.1"/>
        <property type="gene ID" value="LOC126891361"/>
    </dbReference>
    <dbReference type="GeneID" id="126891361"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="393"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="531" mass="61408" checksum="24B6B49145FEA6D5" modified="2025-10-08" version="1">MKRNVGKQRKKIKRNVGKKRRRGVDKIDTLEEKQSYLDNKLEQQQNDLKQQQDNLKSSLERQIVMLERKINTQASLSRIVSVTNVESETAPSSSHPLNLLESGTIRNSKILKPPTFDGQTAWETYRFQFEAAARANGWTEREMSASLVVSLRGQAATDLQFLPQDSPSYDSLVQALETRYGQQHLKQVFQSQLKVRYQKHNESLQEFEADIKRLLHLAYPQAPRDFLEQIGIQAFIDGLHDIEMQQALRLQHHKTLDKALISAQEYEAAKNISRSLPQLKEIRFTENKQVTTTDNEQLVLSQILSLLQNIQQKPRNENRRCFNCGRMGHLKSNCRSRSQARKEEYKNEIRRSPSSTSRSLSQNLTRNDGRWSLRNRFPTTDHRQEENTQEFEVSHLKEQLAISKNKIERLREQVTILQEECKVIQNNAKTTQSNLENECQKLMKEKNVLNKQLQEYQNALNELQVQSQRQLAQKENVTEEFLDKITVLPLGASEKAIAGDDTKADNNGTMKSRQQHPTSKYDTTKTVAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2N6</accession>
    <name>A0ABM5L2N6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516698.1">
        <property type="nucleotide sequence ID" value="XM_050660741.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660741.1">
        <property type="protein sequence ID" value="XP_050516698.1"/>
        <property type="gene ID" value="LOC126891565"/>
    </dbReference>
    <dbReference type="GeneID" id="126891565"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="546" mass="63222" checksum="6676DBE58215118D" modified="2025-10-08" version="1">MNDEKLIKLVRQNNALYDSESKKYCDNSFKDNIWSAIAKELDATEVSQINSRIDTLQEKQNYLDNKLEQQQNDLKQQQDNLKSSLERQIVMLERKIDAQASLSRIVSVTNVESETAPSSSHPLNLLESGTIRNSKILKPPTFDGQTAWETYRFQFEAAARANGWTEREMAASLVVSLRGQAATVLQFLPQDSPSYDSLVQALETRYGQQHLKQVFQSQLKVRYQKHNESLQEFEADIKRLLHLAYPQAPRDFLEQIGIQAFIDGLHDIEMQQALRLQHHKMLDKALISAQEYEAAKNISRSLPQLKEIRFTENKQVTTTDNEQLVLSQILSLLQNIQQKPRNENRRCFNCGRMGHLKSNCRSRSQARKEEYKNEIRRSPSSTSRSLSQSLTRNDGRWSLRNRFPTTDHRKEENTLEFEVSHLKEQLAISKNKIDRLREQVTILQEECKVIQNNAKTTQSNLENECQKLMKEKNVLNKQLQEYQNALNELQVQSQRQLAQKENVTEEGLHVKQDGISFEINGEKVKTKLQNLGKLVNKQKNGDMTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L331</accession>
    <name>A0ABM5L331_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516835.1">
        <property type="nucleotide sequence ID" value="XM_050660878.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660878.1">
        <property type="protein sequence ID" value="XP_050516835.1"/>
        <property type="gene ID" value="LOC126891652"/>
    </dbReference>
    <dbReference type="GeneID" id="126891652"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045271266" description="Cathepsin L1-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="113"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="455"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="543"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="84826" checksum="C5F74DDD7AF6D296" modified="2025-10-08" version="1">MKVFIAIAAFIAVISAGLHEDYEEWISYKAEFSKKYGLAEDKFRFQLFQKKLREIEQHNEKYEKGEIGWSKGINQFSDWTDDEFESILNKQLATTPVLGKSLGVYEADPNEPLPASVDWREKGAVLPVRYQGGCGACWAFSVTGTLEGQVAIHKKQNISLSPQDLIDCTRNYGNWGCKGGGPPSNAYKYVMENGISSEADYPYLEKDDICKNNTRKAITKISGWRQTKRTEKDLISAIAKVGPISVGVGVKGWRDSRHGVHNNTDCGPLNHAVLAVGYTEEYFIVKNSWGPKWGDNGYIRIARGNNICHINEACYYPVLSMNTKKEKVNWLNIKWLRFDKEKPSIIQYKYCLSQENFEEIEVNCKGTAGRKRTSTNLELNQKYLTGLPVSHKKKKDLEYLLNSKVIPDEYSQFIKDIPVSTNNTYSKKSIMKLFVVIACLIAAIFAELKDDYEQWIDFKTKFNRHYGAKENEFRFKIFQKNLRDIEEHNAKYEKGEEQWTKGVNQFSDWTEEQLQSLLNHRLNTIPLRSDSLGVYKADPNEQLPASLDWREKGAVLAVRDQGWCGGCWAFSAIAALEGQVAIHKKQKIPLSPQNLIDCSTENKGCNGGLMNKAFEYIKSHGISSEEDYPFIEKDDNCRTNVTKVLTSISGYKGVNTEQDLISAIAKVGPVSVAVATGKLDWFQYKGGIFNKTTCGTTLDHGVTAVGYTDEYIIIKNSWGPDWGEAGYIRLARGLNMCGINNKYNYYPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3U1</accession>
    <name>A0ABM5L3U1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ryanodine receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517100.1">
        <property type="nucleotide sequence ID" value="XM_050661143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661143.1">
        <property type="protein sequence ID" value="XP_050517100.1"/>
        <property type="gene ID" value="LOC126891831"/>
    </dbReference>
    <dbReference type="GeneID" id="126891831"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4465"/>
            <end position="4492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4659"/>
            <end position="4679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4740"/>
            <end position="4759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="4927"/>
            <end position="4949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="5003"/>
            <end position="5026"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="18">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="578"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1032"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="1490"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1369"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2312"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2955"/>
            <end position="2981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3613"/>
            <end position="3637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3880"/>
            <end position="3906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4549"/>
            <end position="4593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1419"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1453"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1488"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2312"/>
            <end position="2321"/>
        </location>
    </feature>
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        <location>
            <begin position="3623"/>
            <end position="3633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="3882"/>
            <end position="3895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="3896"/>
            <end position="3906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="5130" mass="581775" checksum="5B0A44E6F0ABC85F" modified="2025-10-08" version="1">[encoded data, 5130 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L617</accession>
    <name>A0ABM5L617_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517881.1">
        <property type="nucleotide sequence ID" value="XM_050661924.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661924.1">
        <property type="protein sequence ID" value="XP_050517881.1"/>
        <property type="gene ID" value="LOC126892396"/>
    </dbReference>
    <dbReference type="GeneID" id="126892396"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21756" checksum="6BAE7C9BB87CD8A0" modified="2025-10-08" version="1">MNRCNPEPHFKIVETIEAGRSVLTVVPHKWIKNKILFWPPKNVKNLIKDVNSTPDITWNKIICRIKRNYYKNRIAAETELLEMSGGSATSSTDSEVLGEMKEKNKVRNTKKVTSQQNFETLFASSSSKFCSFQPIIPEETPEPVVESENIILETNFSDEAIISPEAIANAQFLNIIEQVSFYWKHLKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7D4</accession>
    <name>A0ABM5L7D4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518349.1">
        <property type="nucleotide sequence ID" value="XM_050662392.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662392.1">
        <property type="protein sequence ID" value="XP_050518349.1"/>
        <property type="gene ID" value="LOC126892742"/>
    </dbReference>
    <dbReference type="GeneID" id="126892742"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15066" checksum="8233C23BE001EA1E" modified="2025-10-08" version="1">MTDSDFEWLLNLVGPKITKNDTNIRKAITPTERLLITLRFLATRDSYTSLMHLFRISKQAISKIVPEVCIAICEVLGDQIKMPGTAEEWKVVATQFNNLWNFPQCTGVMDGKHIMIQSPEHSGSDYFNYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F317</accession>
    <name>A0A6P7F317_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114324296</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127905.1">
        <property type="nucleotide sequence ID" value="XM_028272104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F317"/>
    <dbReference type="FunCoup" id="A0A6P7F317">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272104.2">
        <property type="protein sequence ID" value="XP_028127905.1"/>
        <property type="gene ID" value="LOC114324296"/>
    </dbReference>
    <dbReference type="GeneID" id="114324296"/>
    <dbReference type="KEGG" id="dvv:114324296"/>
    <dbReference type="CTD" id="129787"/>
    <dbReference type="InParanoid" id="A0A6P7F317"/>
    <dbReference type="OrthoDB" id="411535at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22593">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22593:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028127905.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17609" checksum="AA6FF593751294A7" modified="2020-12-02" version="1">MFDQEFVEVNQINSFLHFLGNIEWRDPWLIALFTFHISIFMMALLTRNYGNFQALLFFCLLLLVYFSESINKMASTNWKIFSRQQYFDSNGLFISVVFSIPILLNCILMVGSWLYQSTQLMTNLKVAQLKEQLRKEQEIKDKKKPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F328</accession>
    <name>A0A6P7F328_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemocyte protein-glutamine gamma-glutamyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114324610</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128278.1">
        <property type="nucleotide sequence ID" value="XM_028272477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F328"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272477.2">
        <property type="protein sequence ID" value="XP_028128278.1"/>
        <property type="gene ID" value="LOC114324610"/>
    </dbReference>
    <dbReference type="GeneID" id="114324610"/>
    <dbReference type="KEGG" id="dvv:114324610"/>
    <dbReference type="InParanoid" id="A0A6P7F328"/>
    <dbReference type="OrthoDB" id="437511at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000002">
        <property type="entry name" value="Erythrocyte membrane protein band 4.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF52">
        <property type="entry name" value="HEMOCYTE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="4">
        <location>
            <begin position="274"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028128278.1"/>
        </source>
    </evidence>
    <sequence length="707" mass="78898" checksum="C26BFC49C28C208F" modified="2020-12-02" version="1">MEPATVTGVDFFHKENAHNHHTCEYELVNAEAPTPVLRRGAVFQLGINLNRTFDPEHDVIRISFGFGEKPTVILGTRAVRPLNPKLNHFPKDPHVWGVMLKENKGSSVIVNVRIPPQVQVGIWNCNIISTIAGQKGVRKDYKFEDDIYIIFNPWCPEDGVFMENEEERKEYVLNDCGKIWCGTFKKPTGKHWIFGQFDEISLPAAIFLLEKSALVTAQRGNPIMVSRAISAIVNAVDDGGLLEGRWDGDYSDGTSPFAWTGSTAILEQYLLSNGTSVKYGQCWVYSAATVTICRALGIPCRSTTNYVSAHDTNASLTIDKYFDASGERIESGPDGACNDSCWNFHVWNDVWMSRPDLSPGYGGWQVIDATPQEVSDSVMRCGPASIEAVRKGEVGFLYDTPFVFSEVNADVVHFQEDEESDWGFSTTSVNQYHVGRLIVTKKPGPTDSNGDSDVWDITHFFKNKEGTEAERLSVYNAVRGVPKALHIYELPNKEHQDVGFELVDIDTVPFGHKFMAQVRIENKSEQERTIKIMLTATSVYYMGTTANDIKKTKGALKLAPHQKQTVRLDVYPKDYLEKLVDHFFVKIYAVANVQETKQVWSEEDDFTLTLPDIKITAPHTAKVGEHCDVKFTFHNPLEIPLTQCSYVLEGPGVTKAVSTKHVDVKAKETITVSASFTAKNAGVKKIVVNFTSKEVHNIHGSTNITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4C3</accession>
    <name>A0A6P7F4C3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage stimulation factor subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CF-1 77 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleavage stimulation factor 77 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114326197</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130266.1">
        <property type="nucleotide sequence ID" value="XM_028274465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499412.1">
        <property type="nucleotide sequence ID" value="XM_050643455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4C3"/>
    <dbReference type="FunCoup" id="A0A6P7F4C3">
        <property type="interactions" value="2167"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643455.1">
        <property type="protein sequence ID" value="XP_050499412.1"/>
        <property type="gene ID" value="LOC114326197"/>
    </dbReference>
    <dbReference type="GeneID" id="114326197"/>
    <dbReference type="KEGG" id="dvv:114326197"/>
    <dbReference type="CTD" id="3354994"/>
    <dbReference type="InParanoid" id="A0A6P7F4C3"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000002">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002655">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="13">
        <location>
            <begin position="16"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028130266.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="82958" checksum="51A10D55C4B99EE7" modified="2020-12-02" version="1">MMETDERLHIDWGNDKLHRTQKQVERNPYDLESWSILLRESQIKHISEVRALYEHLIGIFPSASRYWRIYIEHEMKARNFERVEKLFQRCLMKILNIELWKLYLNYVKETKASLPTYKEKMAQAYDFALDRIGMDIHSYSVWNDYVNFLKGVEAVGSYAENQKISAIRKVYQRGIITPMTGMETFWKDYIAFEQNINAIIAEKMSIERSRDYMNARRVVKELEVQIRGINRNAPSIPPSASPDERKQVELWQKYIAWEKSNPLRTEDTALLTKRVVFALEQCLLCLGHHPDIWYQAAQFLEFSCKILAEKGDVNASKLFSEEAANMFERATSTLLSKNMLLYFAYADYEEGRLKYEKVHQIYNKYLETSDIDPTLAYIQYMKFARRAEGIKSARAVFKKAREDNRSKYHLFVCAALMEYYCSKDKNIAFRIFELGLKKFGAIPEYITCYIDYLSHLNEDNNTRVLFERVLSSGSLEPEKSVDIWNRFLEFESNIGDLQSIVKVEKRRSEVLSKIKEFEGKETAQLVDRYRFLDLFPCTPQELKSIGYTEVINITGAAGKNHILQSIIEFEPDLPLPVPDYSQMIPYKPKAKALPGEHPVPGGTFPMPPTAAHLCTLLPPPNCFRGPFVHIDILMDVFNRIYLPDNFPTPAESNGDVRLFDLAKSVHWIVEEGGGIGLKRRKRTGIGMDGSDDEDTPLPPTNDIYRQRQQKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4P4</accession>
    <name>A0A6P7F4P4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorting nexin-16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114324787</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128435.1">
        <property type="nucleotide sequence ID" value="XM_028272634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4P4"/>
    <dbReference type="FunCoup" id="A0A6P7F4P4">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272634.2">
        <property type="protein sequence ID" value="XP_028128435.1"/>
        <property type="gene ID" value="LOC114324787"/>
    </dbReference>
    <dbReference type="GeneID" id="114324787"/>
    <dbReference type="KEGG" id="dvv:114324787"/>
    <dbReference type="InParanoid" id="A0A6P7F4P4"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028128435.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32704" checksum="6091B47B70D9CC8E" modified="2020-12-02" version="1">MCDSSTSANPISSEYTSTPSRRDRENKFSEKTEDAATTDSEEYLSEPLRYRNFQYSAQSSISNITLSVQNSRIEEENGNCFPQIPNGPISFNNIQIPIVGYEIMEERARFTVYKLKVENKETGDFWYVFRRYTDFVRLCTRLRTNHPNIVQHLPRKRWLKNNFDPIFLEERVNGLQTLVNAILSVPELIASQEIQDFFCLNEPPVYSETSEETKAIFEALEETISYLKQQVREKDASLDSLEEKLHSLSTENENLRKLISNSMMSCQKCQKECENIQKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6R9</accession>
    <name>A0A6P7F6R9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylinositol-binding clathrin assembly protein LAP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114327148</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Binds clathrin and phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131469.1">
        <property type="nucleotide sequence ID" value="XM_028275668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6R9"/>
    <dbReference type="FunCoup" id="A0A6P7F6R9">
        <property type="interactions" value="1703"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275668.2">
        <property type="protein sequence ID" value="XP_028131469.1"/>
        <property type="gene ID" value="LOC114327148"/>
    </dbReference>
    <dbReference type="GeneID" id="114327148"/>
    <dbReference type="KEGG" id="dvv:114327148"/>
    <dbReference type="InParanoid" id="A0A6P7F6R9"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000017">
        <property type="entry name" value="Phosphatidylinositol-binding clathrin assembly protein LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028131469.1"/>
        </source>
    </evidence>
    <sequence length="632" mass="68267" checksum="CF85D8249646989D" modified="2020-12-02" version="1">MAGQTINDRLLAAKHSLAGQGLAKSVCKATTEEMLGPKKKHLDYLIHCTNEPNVSIPQMANLLIERSQNTSWIVVFKALITTHHIMCYGNERFTQYLASSNVSFQLSNFVDKTGVQSAVGARTGYDMSPFIRRYAKYLNEKALSYRSVAFDFCKVKRGKEEGTLRTMNTENLLKTLPILQNQLDALLEFDCTANDLTNGVINMCFMLLFRDLIRLFACYNDGVINLLEKYFEMNKKQCREALDLYKKFLIRMDRVAEFLKVAENIGIDKGDIPDLTRAPNSLLDALEQHLASLEGNTPTAAAAQKNVKSGVSALSNTSNAFGTAVDDSFKQAAVAEEEAALNHYRASVGSPSAASTNPFLSDEPTVTGEPILDLFSSGPAPEAARPAQSSNALDDLLSLGGNPFADFSAAPVTTTAAPLGQDAFGSTATTTDNNMWGTNGFGGNNLFQAQQPIQAQPFGNANDLSGLFNTNEPSVFDPLGDSKTMSAQIIQQQPVAAQPPKAVPAKLLTGDLESSLTSLVDNLTMDSGSRGPQWNSPKNQAKPAGGWPAQPMTAPGYRPVGQAMGQPMMAQQPMMGQGMMGQPVMGQTMQPMMGQVNQFAAMQQPVMGSPKMNAGPPQQQQQEVTFDPFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7A9</accession>
    <name>A0A6P7F7A9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114325442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325442</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129315.1">
        <property type="nucleotide sequence ID" value="XM_028273514.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498748.1">
        <property type="nucleotide sequence ID" value="XM_050642791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7A9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642791.1">
        <property type="protein sequence ID" value="XP_050498748.1"/>
        <property type="gene ID" value="LOC114325442"/>
    </dbReference>
    <dbReference type="GeneID" id="114325442"/>
    <dbReference type="KEGG" id="dvv:114325442"/>
    <dbReference type="InParanoid" id="A0A6P7F7A9"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129315.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="38511" checksum="821CD361C814B324" modified="2020-12-02" version="1">MSRDKQLITPLKEARRFMIDCFKAVGANQTHAEIVADNLLEADYRGHYTHGMNRLEKYIKFLQHGLVSPNAVPTIDKETEATALVNGNNGFGAVVGQYCMDLAIEKAKNIGIGLVVCHGSNHYGMAAMFALQAIKKGFIGFSTTNSPCLLVPTRAKKSALGTNPIGFGVPANDGDSFVLDTSTTVAALGKIEIQRRKGEPIPPGWALNKEGKVETDADIAFQEKLLLPLGGEEINAGYKGYGLAVFVDVLSGILSGSNYGPKVPKFGTVENLGQAFIAINPQVFAPGVENRMSDLMNYLRNMEPVDPNLPVLVAGDPSRQNMEKVHRDGGLSYVQNQHDTNKKLAERLNVAPMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7E9</accession>
    <name>A0A6P7F7E9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114325500</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129360.1">
        <property type="nucleotide sequence ID" value="XM_028273559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7E9"/>
    <dbReference type="FunCoup" id="A0A6P7F7E9">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273559.2">
        <property type="protein sequence ID" value="XP_028129360.1"/>
        <property type="gene ID" value="LOC114325500"/>
    </dbReference>
    <dbReference type="GeneID" id="114325500"/>
    <dbReference type="KEGG" id="dvv:114325500"/>
    <dbReference type="InParanoid" id="A0A6P7F7E9"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028129360.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9569" checksum="B56F3B7E74511AC5" modified="2020-12-02" version="1">MPAETIQYSEKYCDEMYEYRHVILPPDLAKLVPRPHLMTETEWRNLGVQQSPNWVHYMLHAPEPHVLLFRRPLRLVHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7U0</accession>
    <name>A0A6P7F7U0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sodium channel protein Nach-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114327233</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131581.1">
        <property type="nucleotide sequence ID" value="XM_028275780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7U0"/>
    <dbReference type="FunCoup" id="A0A6P7F7U0">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275780.2">
        <property type="protein sequence ID" value="XP_028131581.1"/>
        <property type="gene ID" value="LOC114327233"/>
    </dbReference>
    <dbReference type="GeneID" id="114327233"/>
    <dbReference type="KEGG" id="dvv:114327233"/>
    <dbReference type="InParanoid" id="A0A6P7F7U0"/>
    <dbReference type="OrthoDB" id="6436100at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF253">
        <property type="entry name" value="PICKPOCKET 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028131581.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58551" checksum="73E331003BE2C825" modified="2020-12-02" version="1">MKHKIKHENIENMPFKNTYEEYVYHSSLAGFVHLNSPGAIERYIWYIIHLLSLACTCFLINYTWQNFMKNPTMTTVEAMGSRLAEIPMPGISICNINKISRRKAQIYADELAARSRVSAEEILSNITLLGYLYEYNLPVKPERIIYFQNFLEKWDSAANGYYNTTDRLYRLQPTCFEVVKDCIWNGKRRPCEDIFVTELTMDGYCCVFNYVAHLSTTKISPIVIANDNKPISFGPTAALDFTILSNSSDTFFTTIATEAPVKILFSIPTDFPDTTSGGLVEKIIDRGTEIFLQVSSINTVATDEVKKYPPSKRGCIFSDEIKTLFGSYSYSDCIMDCKIRSIVALCQCVPFNFINVFNNPNDHYFQCTLGDLQCLNAYTNKWKTLYPSDFTGTGLEREKQDSIQCEHCIPTCSDTMYDVSSEFAIIYENGSVANYSLVHISYEKSLGMFNKQDAYFYWFDMLSMFGGICSITMGLSFVSVVEIFYFLIFVGIKKHLRKKRNKGFHDEHVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCA5</accession>
    <name>A0A6P7FCA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Gastrula zinc finger protein XlCGF57.1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114328568</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133251.1">
        <property type="nucleotide sequence ID" value="XM_028277450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277450.2">
        <property type="protein sequence ID" value="XP_028133251.1"/>
        <property type="gene ID" value="LOC114328568"/>
    </dbReference>
    <dbReference type="GeneID" id="114328568"/>
    <dbReference type="KEGG" id="dvv:114328568"/>
    <dbReference type="InParanoid" id="A0A6P7FCA5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000064">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028133251.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="62686" checksum="FE7EE0FB72EDAC60" modified="2020-12-02" version="1">MECKSFKDYENQPALICSKDDKDSLKEHVKVEIQECTFESTHTKEPVLTESCSENVTLKSCLVKDEPSESYYIDELHDVKVEIKEEPEEWQLIVNHSENHFEISNSNNLDSNSSNEISRNSLSQTEDEIQETLPEDFSNNEKQIHQDSTEKPLKCLSRKEDEIQNTLPKDFSNNDKHILQDSSEKLIKSLSRIGDEIQNTLPDDFSNNEKHIHQDSSEQLGKCLSQREDEIQNTLLEDYSNNDKHIHQDSSEKLAKCEICSNSFSQTSDLKNHLIMHNCDQTFKCEICCKPFARATALKTHFRTHTGEKPFKCEICLKQFSQKGHLKAHLQMHTGEKPFECEICLRQFAQGHLLKSHLRIHGIGKPFECEVCFKKFTHKCNLKGHLKIHTGEKPFQCKICFKQFTHNCNLKSHLKMHTGETPFECEICFMRFAHGHILKSHLRVHNIGKPFECEICFKHFPQASHLKKHFKTHTGEKPFKCEICFKHFAQKCHLKTHLKIHTGEKPFECEICFRQFARRHILKCHLKTHSTEIYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FE97</accession>
    <name>A0A6P7FE97_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-33B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329213</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134051.1">
        <property type="nucleotide sequence ID" value="XM_028278250.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511941.1">
        <property type="nucleotide sequence ID" value="XM_050655984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FE97"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278250.2">
        <property type="protein sequence ID" value="XP_028134051.1"/>
        <property type="gene ID" value="LOC114329213"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655984.1">
        <property type="protein sequence ID" value="XP_050511941.1"/>
        <property type="gene ID" value="LOC114329213"/>
    </dbReference>
    <dbReference type="GeneID" id="114329213"/>
    <dbReference type="KEGG" id="dvv:114329213"/>
    <dbReference type="InParanoid" id="A0A6P7FE97"/>
    <dbReference type="OrthoDB" id="10006973at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002685">
        <property type="entry name" value="RAB33A, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028134051.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24875" checksum="EA97762732F6BAAC" modified="2020-12-02" version="1">MAEVPSNNLQPAASVSHVQIQKQGKIFKIIVIGDSSVGKTTLTYRFCEGKFLELCEATVGVDFRSRTVNLDGEDVTLQLWDTAGQERYRMSMVRHYYKNAHAVVFVYDVTNSGSFDSLKKWIDECNNNCLQDVPKILVGNKCDGVVAVTTNVAQRFADQYSMPLFETSARLDSQCDNVEAIFLTLAHKLKNQKHFLPMQTTALRIHDSVQPNPNSKQSGMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEE0</accession>
    <name>A0A6P7FEE0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Gastrula zinc finger protein XlCGF52.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114328517</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133182.1">
        <property type="nucleotide sequence ID" value="XM_028277381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277381.2">
        <property type="protein sequence ID" value="XP_028133182.1"/>
        <property type="gene ID" value="LOC114328517"/>
    </dbReference>
    <dbReference type="GeneID" id="114328517"/>
    <dbReference type="KEGG" id="dvv:114328517"/>
    <dbReference type="InParanoid" id="A0A6P7FEE0"/>
    <dbReference type="OrthoDB" id="6671661at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000226">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="16">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028133182.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="48357" checksum="3C3A4E102FA0D681" modified="2020-12-02" version="1">MKMEEITLHYTDFPQICRICLIKQNLQPFSQNLYDFYVNLVTSEIVKNEDFPQKICLECSFKLEEMYSFIKKSKIREMMLHKIFEERLIKTSSSDQDIADNDTDTVEESNIKSEQRRDISKKRYKSKFKMKERSPFECKMCNKVYHSKSSFANHCRMHKSKREPKTFLCNYCGKHFMKSSHLERHIRSHTGIKPFKCDKCEKCFGQGNDLKRHLLTHTREKIFQCTHCNKGFHQKSCLANHIMTHSNERNYSCNFCDKRFTLKTYLNVHLRIHTGQKLFQCPHCDKQFPQKGGLNNHILTHTGEKPFKCSQCEKTFVQSNHLKEHERIHSGEKPYICSFCGKTFAYSSTLKVHLRQHTGETPHICSYCGKGYRDASNLRRHVTRHHASNNKVVKKEIKIIKAENIVSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEE4</accession>
    <name>A0A6P7FEE4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCY1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328520</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133187.1">
        <property type="nucleotide sequence ID" value="XM_028277386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEE4"/>
    <dbReference type="FunCoup" id="A0A6P7FEE4">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277386.2">
        <property type="protein sequence ID" value="XP_028133187.1"/>
        <property type="gene ID" value="LOC114328520"/>
    </dbReference>
    <dbReference type="GeneID" id="114328520"/>
    <dbReference type="KEGG" id="dvv:114328520"/>
    <dbReference type="InParanoid" id="A0A6P7FEE4"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000179">
        <property type="entry name" value="SCY1 like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000189">
        <property type="entry name" value="SCY1-like pseudokinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028133187.1"/>
        </source>
    </evidence>
    <sequence length="871" mass="97070" checksum="CC15A7B3D6E8F9F4" modified="2020-12-02" version="1">MDVFNKVINQVSSSVHSTVSQLSGVLPGNPVTREFESSAHIASAGPGLLWKIYKGNKRSTRQEASIFVFEKRQLDRYSKTDRELILEVLRRGVVQLTKIRHPKILTVQHPLEESRDSLAFAAEPVFASLANVLGQTTNMPQPANMSDYKLFDIEIKYGILQLAEGLAFLHNDVKLLHKNISPESVIINTQGAWKVFGFDFCVINTNPANMPPSYVFEEYSATVPPVCQPNLDYLAPEHVLSLVQSQASDMFSLGMLIYTLYSPDRKCYKPVRDLQQFRARAQDLKKFTTGKIQFVPEELREFIKLLLNGTPEVRPDAHQFVKIPFFDDIGIKTLTYLDSVLQWDNLQKSQFYKGLPEALTKLPHRVKLQRVVACLAHDLGQPAMVPFILPSLLEIAQGCTQKEFCSYILPLIKPLMTLLEPVQVLLIMLQHMELLLKLTPAEDIQRHVLPMLYRGLDSDTPQIHELCLSVLPTFAGLLDHSNVKNSLLPRIKKLCLNTSTLSVRVNCLLCVGRLLEHLDKWLVLDEVLPFLPQIPSREPAVLMGILGIYKLALTHKKLGITKEIIASRVLPFLIPLCIENGLTIPQFNALTALVKDMFQIVETEHRTKLEQLNSVKDEQKTLASTTPIVMPKSKPIELDSAFSGLGLDNYVPGMSLKQKQQLAQQQDSLKVFSSQPSIEPKKVDNAPKSVPKDLSSSLLDDWVSSTATSSKNQSFNASNTQNLSSTDQTSKNSPSNTSTFVGNTGFNQTALMSSNSNTQWQMGKQNNSTPNYSPFTTQNQNFMNNNLSTAGSNPWSSSHNAITYNKPQNDTSQNWSAFDNLLPGTNSNINTGKVPMNKMMSHNVPLLPSSNTNSGAKSGGLSNDDIMDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFC9</accession>
    <name>A0A6P7FFC9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vitellogenin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114329555</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134501.1">
        <property type="nucleotide sequence ID" value="XM_028278700.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278700.1">
        <property type="protein sequence ID" value="XP_028134501.1"/>
        <property type="gene ID" value="LOC114329555"/>
    </dbReference>
    <dbReference type="GeneID" id="114329555"/>
    <dbReference type="KEGG" id="dvv:114329555"/>
    <dbReference type="InParanoid" id="A0A6P7FFC9"/>
    <dbReference type="OrthoDB" id="160294at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.20:FF:000003">
        <property type="entry name" value="Vitellogenin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027962674" evidence="8">
        <location>
            <begin position="17"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="9">
        <location>
            <begin position="21"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="10">
        <location>
            <begin position="1455"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1762"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="822"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028134501.1"/>
        </source>
    </evidence>
    <sequence length="1788" mass="203114" checksum="D5F84B07B427B480" modified="2020-12-02" version="1">MWSPIVLCLFVGVTLASNPAWKHGAEYKYQLEGRTLANVDAISQQQSGILFKGTLRLQPLSEGKLRGIIEKPVYDEIHAELADGWQTEIPDKQVSWKQLKMVQTPFEVEMRNGRITGLIVSKSLANWEVNFIKSIMSQFQLNTKGEQLIDNPLNSLPEDGPNKQEAVFVAMEDTLTGKTETLYLIRPLPDQVVQRKSSEAKYLDAAENDDVIEIVKHKNYSNAEELPAYSYGFAKLRYGEPADNQMGDILTRDTYSRVIVTGSLDKFTIQKTFTIHKAFVSLTLSDNDKASVVSEVRATLEEIKSQEQTIDEVPQPVNVGNLVYSYGKPSALTGASASRRSSSNAHRYDQDDFRRNNIRDRRSLQFSSEESSIESAEESARDNMQEQPDLKEASPRPFLPYTVGYEGMSIKQKINVVQEVQKLAKEIAQRMKDDHRTHHEQVLGKFQTMVSLTRIMTYQELQQAAQNLYTNKRGSENAEWSVLRDAVAASGSGPALLLAKDLITSGKLSGQEASLFIATLTGAVREPTPEFLKVLFDIVKNPVVQKQWPLNNTALIGLTDIINRVYVDQEQSRNRFPTESFGSFETREGEQLIKNEVLPYLSKKLKEAVDNDETHQVHAYTRAIGNTGSYYFLKTFEPYLEGKQPASQFQRMLMILAMEKLAMSHPNTAQAVLFRVYQNPAESREVRMAAVFQIMRTGPSPQMLQAMAEYTNIDDDNYVNAAVVSAIRTASELEGEEYVEISKAAEAALELLDDTKTHGLRHGADYLRTYIVKELQKMYKESTQIFGSDDSMVPKGIRYSLQQHMGQIKRRIVNIQAMCSSMDDLLKVVNEQTADFQQQEKQQKQKSQEQEKNQWSSYNIAKLLNIQPDNREQLEAFIFMEMADQYLMTGLDNRTLERLPEAIREWEEELKKENEMNMYKLTTREMAVAFPTGLGLPFLFTYDVPMLAKLEGKLRATSNPQISQNGKINIPNQIDINVDAQVVISSKVQSRVSFVTPVHHLQNFAGFDKHWEFNLPVRAQVKFDFKNMNAQAEVELKADKEVPLFHYSTVPYTSKSDVTDFQPLSENHNTKIIRQDDLQSFESTFGKKTTGMAFRVGIQHKREFFNTLSLNRILSEQGPLDAMKSLWDDNSIQYSEINVNFRPEESATRKAMVKISYESKYRSPPDSDSASEWILNENAEPAQRQEGLMKKVAADIKNVQVVSLDATLEFQGQKKIKYILTGAVAKSNVDPKSRVMVSYKRKGDAKPHELHMEAKSYIPNTNALDLEFTLQNEPVANSEIKIKFGDSEKPLSKVELQVELRRTEERKHFLKQLPIYRQCKDEMRAGNKQLAACTNVTEAANLLDAVSVKLHHENLGEDMVEYIKSGFNVVRALSYPELYISQKNVDSSENEVKIQAQFYPDLQGVNVSIKAEGEQSIFTKIPVSELAQEILVAHPVFHLRSRLIKYAWEMDTYRPFCTIDKTHVNTFSNRTFQAEISKHWTVALQYLNGNSRLQQEKSIPEQLKQQPEHYVVLTRESSVSSNKKDVKIVLSAPETNFKTVEIDMTPAQSQGSGPRGKVSVNGQQVPISEKQSHDIEDGFVQMYSLPNGEIKVEVHGGDFYVIYDGNRVKMSATSDKLRNRIVGICGQFTEQESDDFLTPQACVAVDEEEFLRSLEVEGQEGKQLRDAFNGNSKKCLDREIPRFVNVINARDYRSQNSQPSKSTRCTHFQTQFHEEGDKICFTIHPQPTCSSHCQPRKQITKKVPVHCVQNGKAAKMWKQQIQNGQSPDFSDKSEHRAVSMKIPESCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGM9</accession>
    <name>A0A6P7FGM9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Centromere-associated protein E-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114330088</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135204.1">
        <property type="nucleotide sequence ID" value="XM_028279403.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135205.1">
        <property type="nucleotide sequence ID" value="XM_028279404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279403.2">
        <property type="protein sequence ID" value="XP_028135204.1"/>
        <property type="gene ID" value="LOC114330088"/>
    </dbReference>
    <dbReference type="GeneID" id="114330088"/>
    <dbReference type="KEGG" id="dvv:114330088"/>
    <dbReference type="OrthoDB" id="6742802at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028135204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028135205.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="68571" checksum="60AED88D8E62E729" modified="2020-12-02" version="1">MEQHMLESEEVSFPKEYQINPQLNTNFDDQTMDDQPPEAANLTSENIEMENMNNLNLKLNYKQAEAIIHKQCKAFIKQQKTQKTTSEILTQQNNHILQKINAEKKILGLLQLEADKLNTDIRRLDEETSHIVQRQQNACEIVEEMQKYVTELEQNAKNVENNRNELLTKAENQKEKFKSTIDAAVKEYNRLRDLFSAGNNPSGDGDRDSLRKENLHLKQQINENREEFKLLEILYSLKVEKENLETGICEKKNSYNEINKNLDVLESIQEHTVTQFNEEYEKYIKLRVDDLSCDLNRLNQKITAVKEQVFDNEISLKRTRIGETKEMIEKRKEEIAEKQKRIDQMSGEYISKVDALKKQIVDVEKEAAQSGESNQENMQASESLIKTFCAKQVEKDKLLNKKFTLQEKINADQVLLVEIKLLKEKIAAKENAIESLTDAITNISDDKSILELSRKRSYLDACKTFLEERAEITKKKRDEEEFNMQQLQASVEEIKNKCEEKRNEIFKKTGKRVSPKGILKRKGQNKTPPVSPKKVTFINVSTESSVSTQDDEEDTFEKILKQYRMKHRDLKSNPKPNKMKRLVLEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGW1</accession>
    <name>A0A6P7FGW1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114330164</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135284.1">
        <property type="nucleotide sequence ID" value="XM_028279483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGW1"/>
    <dbReference type="FunCoup" id="A0A6P7FGW1">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279483.2">
        <property type="protein sequence ID" value="XP_028135284.1"/>
        <property type="gene ID" value="LOC114330164"/>
    </dbReference>
    <dbReference type="GeneID" id="114330164"/>
    <dbReference type="KEGG" id="dvv:114330164"/>
    <dbReference type="CTD" id="34251"/>
    <dbReference type="InParanoid" id="A0A6P7FGW1"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028135284.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="51540" checksum="407742D4A96BCDF0" modified="2020-12-02" version="1">MAKRTFLRRNLLTILTVAGVVGGTLTGILIRATTGNHWSKRDVMYLAFPGEIFLRMLKCLIIPLLMSSVIQAIGSLDLSLSKKIAMRSILYYATTTVFAVVLGIVLVLTIRPGVGATPWTGDASERVTRHVLTQDTLLDLIRNLFPPNIVQACVSQSQTFLTLPKNETVKNMGHEYWKFEERYEPTTNVLGLVVFSITFGISLGKMGERGKILLEFFNALSETMMIITSWVIWISPVGVFFLVAAKVLEIVSFADLIGRLGLYFATVLTGLFLHGFGSLSLIYFLAVRKLPFKIIVQLSQVLVTAFGTASSSATMPISIQTMDQMGVDPRVTRFVIPIGATINMDGTALYEAVAAIFIAQLKDIPLTFGKTVAVCVTATAASIGAAGIPQAGLVTMVMVLDTVGLPSEEVINIIAVDWLLDRFRTTINVMCDCLGAQLVDYLSVGELGALTESDKVNAQPQELIEISKVDSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI58</accession>
    <name>A0A6P7FI58_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">von Willebrand factor D and EGF domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114330453</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135596.1">
        <property type="nucleotide sequence ID" value="XM_028279795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI58"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279795.2">
        <property type="protein sequence ID" value="XP_028135596.1"/>
        <property type="gene ID" value="LOC114330453"/>
    </dbReference>
    <dbReference type="GeneID" id="114330453"/>
    <dbReference type="KEGG" id="dvv:114330453"/>
    <dbReference type="InParanoid" id="A0A6P7FI58"/>
    <dbReference type="OrthoDB" id="10060424at2759"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053255">
        <property type="entry name" value="EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24047">
        <property type="entry name" value="FI01909P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24047:SF32">
        <property type="entry name" value="FI01909P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028395146" evidence="4">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028135596.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="37180" checksum="4805BC804D366928" modified="2020-12-02" version="1">MAFKLVVGATALMAFSLLSQSVEAAQLQGVARNNSRRGICTLEVPTIDLIPAEDRHGVIPRGNGSRNGYSKIDVCCSGYERVPRTHLQCEPVCDHCENGNCTSPGHCECKRGWIHDPYHKDCIPTCPERCLNGVCTITGQCSCNAGNTLSSSGKYCLPHCSGGCGVGGNCVGPETCACDKGFSLDARTRKCNYHCEGGCGEGSCIGPNQCSCKPGYRQAGHSCVADCPRGCHNGDCVAPNRCSCKAGWALDGTGTVCTPHCNNPCLNGDCVAPNQCKCKEGYIEAPNSIRSQTCVAHCPGGCPNGSCTAPNFCICNPGYVKERKGSNNCVRRVRRSLMHMELIPEAVLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ05</accession>
    <name>A0A6P7FJ05_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114328524</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133190.1">
        <property type="nucleotide sequence ID" value="XM_028277389.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P7FJ05">
        <property type="interactions" value="1808"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277389.2">
        <property type="protein sequence ID" value="XP_028133190.1"/>
        <property type="gene ID" value="LOC114328524"/>
    </dbReference>
    <dbReference type="GeneID" id="114328524"/>
    <dbReference type="KEGG" id="dvv:114328524"/>
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    <dbReference type="InParanoid" id="A0A6P7FJ05"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028133190.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33868" checksum="DCEADE70F9331387" modified="2020-12-02" version="1">MLFYLRIPIISKAVNVICRMSGKGTMERIKQNAQLAKQTIEELKNELNIINNEYNTLLSRQLQEENAKLLAAVEDAKKKLIKLEVQNGVKQVPVPNQTVNVSAVEAPQADINKDEPKAPAEAPKPKKEKKAPKEQKVAEELPIDVGRLDLRIGKIEDIKRHRDADTLYVLQINVGEEKPRTVCSGLVKHIPMEELRDKTVVALCNLKPVKMRGITSEAMVMCASSEAGVETLIPPANSGPGDLVTCEGYTRQPDSVMNPKKKIFETVAPDLHTNDNLEACYKNIPFKVEGKGVCYSKTLKNVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FML3</accession>
    <name>A0A6P7FML3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neuroendocrine convertase 2</fullName>
            <ecNumber evidence="13">3.4.21.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prohormone convertase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC114330885</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.</text>
            <dbReference type="EC" id="3.4.21.94"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.94" evidence="13"/>
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        <property type="nucleotide sequence ID" value="XM_028280306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FML3"/>
    <dbReference type="FunCoup" id="A0A6P7FML3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280306.2">
        <property type="protein sequence ID" value="XP_028136107.1"/>
        <property type="gene ID" value="LOC114330885"/>
    </dbReference>
    <dbReference type="GeneID" id="114330885"/>
    <dbReference type="KEGG" id="dvv:114330885"/>
    <dbReference type="CTD" id="43215"/>
    <dbReference type="InParanoid" id="A0A6P7FML3"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030537">
        <property type="term" value="P:larval behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.850:FF:000005">
        <property type="entry name" value="Neuroendocrine convertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000020">
        <property type="entry name" value="neuroendocrine convertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000004">
        <property type="entry name" value="Proprotein convertase type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF13">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17 18" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="466"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="16 17">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_028136107.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="69961" checksum="B3FE51912345E7C2" modified="2020-12-02" version="1">MPPAWRPFYLILISVCAASATLDIFSNSFLVRFKRDVHQEEAHEIAQRHGFVNMGPLLGSRREYHFINHGIPIARTKRSVPHIRRLKVDPLIHSAVQQTGFIRVKRGYKPLKVENLVKIEPHEDPSDPYFPLQWYLKNTGQNGGKAKLDLNVEAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNYNSKASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRMLDQPYMTDLIEANSMGHEPNLIDIYSASWGPTDDGKTVDGPRNSTMRAIVKGVNEGRNGLGNIYVWASGDGGEDDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAKDPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANNKLSWRDVQHLTVLTSKRNSLFDAKGRFHWTMNGVGLEFNHLFGFGVLDAGAMVALAKRWKSVPPRFHCEAGTVEKIQKIPSKKSLIIKITTNACKGENTEVRYLEHVQAVISLNATRRGEIELFLTSPMGTRSMILSRRQNDDDSRDGFSKWPFMTTHTWGEYPQGTWTLEVKFNSQIPQRGYLKEWSLMLHGTKEPPYTELPVLDPHSKLAIVKKAHESRSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRM5</accession>
    <name>A0A6P7FRM5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">mRNA export factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114330379</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135520.1">
        <property type="nucleotide sequence ID" value="XM_028279719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRM5"/>
    <dbReference type="FunCoup" id="A0A6P7FRM5">
        <property type="interactions" value="2773"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279719.2">
        <property type="protein sequence ID" value="XP_028135520.1"/>
        <property type="gene ID" value="LOC114330379"/>
    </dbReference>
    <dbReference type="GeneID" id="114330379"/>
    <dbReference type="KEGG" id="dvv:114330379"/>
    <dbReference type="CTD" id="8480"/>
    <dbReference type="InParanoid" id="A0A6P7FRM5"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000084">
        <property type="entry name" value="mRNA export factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028135520.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40290" checksum="BF73954539FCE2D2" modified="2020-12-02" version="1">MFNQSGLGTFGAATTPSPANPMKDFEVVSPPEDSISSMAFSPATLPQNFLIAGSWDNNVRCWEIEHNGTSVPKSMQTCGAPVLDVCWSDDGSKVFMAGCDKQAKMWDLASNQVVQVAMHDAPIKTCHWIKASNYSCLMTGSWDKTLKFWDTRSPNPMMSINLPERCYCADVDYPMAVVGTAGRQIIVYQLDSKPQEYRKLDSPLKYQHRCVAIFKDKKKQPTGYALGSVEGRVAIQYVNPTNPKDNFTFKCHRSNGTPNGYQDIYAVNDIAFHPVHGTLATVGADGSFSFWDKDARTKLKPSELMEQPISRCAFNHNGQIFAYSVSYDWSKGHEFYNTHKKNYIFLRPCYDELKPRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVV7</accession>
    <name>A0A6P7FVV7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114331621</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028137038.1">
        <property type="nucleotide sequence ID" value="XM_028281237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVV7"/>
    <dbReference type="FunCoup" id="A0A6P7FVV7">
        <property type="interactions" value="1858"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642458.1">
        <property type="protein sequence ID" value="XP_050498415.1"/>
        <property type="gene ID" value="LOC126879443"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FVV7"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000068">
        <property type="entry name" value="ALG5, dolichyl-phosphate beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="67"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028137038.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37560" checksum="6C46D14FB1227C08" modified="2020-12-02" version="1">MDFGIILFVGSAFAVSILLFICILMVATSSTYPVVIRSKNEKYFIDPVTGKQVPFPSINEKSSVHLSVIVPAYNEEERLPLMLDECIEFLENRCKDLPNYKYEIIVVSDGSRDKTVEVAHVYAKKIVGNEKLRVLHLEQNRGKGGAVRLGMQSARGAVLLFADADGATTFADITKVEDGLLNLINCDYQKDPSKVEEKLAISMGSRAHLEEEAVASRSFFRTILMHGFHFLVWLFAVRGLRDTQCGFKLLTREAARICFESLHVERWAFDVEMLYIAQTLKIPIAEVAVRWTEIDGSKVTPVWSWIQMGMDLGLIWLRYTIGAWKIKSKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYZ7</accession>
    <name>A0A6P7FYZ7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Sorting nexin-14-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC114335669</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141745.1">
        <property type="nucleotide sequence ID" value="XM_028285944.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141746.1">
        <property type="nucleotide sequence ID" value="XM_028285945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYZ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285944.2">
        <property type="protein sequence ID" value="XP_028141745.1"/>
        <property type="gene ID" value="LOC114335669"/>
    </dbReference>
    <dbReference type="GeneID" id="114335669"/>
    <dbReference type="KEGG" id="dvv:114335669"/>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="324"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="550"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028141746.1"/>
        </source>
    </evidence>
    <sequence length="917" mass="105812" checksum="36128CA3CCA40738" modified="2020-12-02" version="1">MVYEEIKYNLRLVSDDKLVRTVTIGITLSVLLFGIFFRPLGALVIYVSYLFGFTVAWFLVKYKTKTTIYLQRLINFYRGHISVKKTLKPSCSICDDLSCRRHQQTRSITPWKHIYITAELNNRIEHFYERIISTFISSWYDHFTDDKDFVNELRYCFRFSTATVVNRLLELDIGDIVANKLVPCGVRHIDDYLYIQQIAKLKNVRFNEVVIEYLGKRLHAAATNRKNELGYLRHLVSSLLNHVLPGNYLKCRNFSVMMREVLAGWVLLPMMDVIADPNILNYLVILAATYKSKKTTKSNQNTEEVEFLCNYISTESKVSSFSTSLNKIKKNTELLYAFMQFLKNNDNVNLLQFCLAVDDFNVKLLTPELSKKQVEELHVEAKKLYKEYLDKNSFSFISCPSEISEDFKFLMQDDYAVEKLSKLSKLLYTAYDFVFNVLESVWLPQFFHSNEFYGYICGPKAMTGFNKQGQNKTPLLSFGSPSKDRLKKYYEPTTGQGAVSKISSSLGKIKGVLKTNQPIEGAFFPLESQSVENGTTDEIFLHECKSLFRDMSTWKISIPTFQTSPTNKVIYFYVSVERMDVHVGDTKKNWIVLRKDQDFYTLKAKLVEFHGESEICDSPLPSRKAGSSIETRLVKYEEFIRKLLKKSNLKGSDLLYYFLTTEQDFATYLAANASNIQDIGNIYQSVAYKLRKEKGQHLDPFMNSFLMSTGVTKTDKFEWAEIGEETDSLISKHMGSFPKTYRNQVFNDNFGVPYNILKDTMSNSLSPDGITESAFYLMKNIFKIPNGLLRLYASICSIAQQFVDLCARTIIEKKIKSSLNQSNLAYLIKQLEDVIFDEHTPVSKEELSRRKVRAVEELENSISNILTQILGPGIKDGAKLLLEIVQNPHFNKQLAYNLLDIVLTEMYPMLDKNEEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1N8</accession>
    <name>A0A6P7G1N8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proline-rich nuclear receptor coactivator 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114333299</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138958.1">
        <property type="nucleotide sequence ID" value="XM_028283157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1N8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642081.1">
        <property type="protein sequence ID" value="XP_050498038.1"/>
        <property type="gene ID" value="LOC126879128"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G1N8"/>
    <dbReference type="OrthoDB" id="6688745at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026780">
        <property type="entry name" value="PNRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15405">
        <property type="entry name" value="PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028138958.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14192" checksum="482A76995EA70BA8" modified="2020-12-02" version="1">MAMATKHSEGGRIVGITSRALRYPSKTNQQQGVLQKGTPRRGESSIQRLNASTRGHSPNGSSPRTSPGLVAGHYAGCKFSEPPLPSALPLPPKHWMQTARPSRLTFYPTIPVASDHKDVAQQLKMLLKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7K9</accession>
    <name>A0A6P7G7K9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114336774</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142952.1">
        <property type="nucleotide sequence ID" value="XM_028287151.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287151.2">
        <property type="protein sequence ID" value="XP_028142952.1"/>
        <property type="gene ID" value="LOC114336774"/>
    </dbReference>
    <dbReference type="GeneID" id="114336774"/>
    <dbReference type="KEGG" id="dvv:114336774"/>
    <dbReference type="InParanoid" id="A0A6P7G7K9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="95"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="414"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="820"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028142952.1"/>
        </source>
    </evidence>
    <sequence length="1353" mass="151396" checksum="422D4B29BDA3739E" modified="2020-12-02" version="1">MDPSEVKYNPNPRENANIFSILFFGYTIPTFRTGMTKVIDVDDVYNTLEGDKSDYLGNRLEKHWNTETELVNKRAKKKPSLLKAIVKTFWVEYAFLGLITACNDLVIRTFQPYMLGGILDYYAPGSTKSKFEAYIYGVGMVTFTFMGSLIMNQYVTNAAHIGMKMRAAACAVVYRKATRLSRTALGDTPGGKVVNLLSNDVARFEMASIMIHQMWIGPISGIIVMFMLYQRSGLSGVAGILVIVLMAPLQAYSGKLASKYRKMTALKTDERIRLMDEVVLGIQVIKMYAWEIPFQKVVGLARSAEIKIVKKNAYIRALFMTLGMVTTRLALFATLLTISLSGEQISAAKVFVLMSYFNLLSSTLSGIFVRGITELAELHTSIKRLQEFLENDEYKYQQQNKIISQKNENSKSAINVENLTARWNSSSSDCTLYDINLEVGTGKLIAVIGPVGAGKSSLLQALLGELDIVQGSITSNGDYSYASQEPWIFSATIRQNILFGADFDRKRYKEVIRVCALEQDLHQFPQGDFTVVGDKGASLSGGQKARINLARAVYRNKDVYLLDDPLSAVDIHVSKVLYEKCINGFLKNKTRILVTHQVHYLKNADKIIILNNGKIENEGTFNELVKSDNAYAKLLTAEPELSEEEKAKEFELVRQISRVSKRSRKSSLASVVSSKSFVESMLEEEDGDDDSYDEYEDKKPEMKDLQEESSKGKVFGSLLIQYFRKGANFCNVVMMLSLYVLVQVSGSLVDYFVSFWTSIEDARAAQILEASTLDNLNFTGATDVPSTLSDYFTDGTSTVRPKPVWESVLDYANWSSETCLYIYGSLILVVVLLTLARSFSFYSLVMSCSRNLHKYLFQGIIYAKMRFFDTNPSGRILNRFAKDIGLIDEAIPRVLLDGGSMLLQMVGSLVLVAVANPYAIIMAAILAVLTGLVRKMYLSTSKNIRRVEGILRSPIYTHLNSTLQGLPTIRALRTEKTLQREFDKLQDYHISVSFMSIACGSAFGFTLDMFSCIFITVLIFSILTFDEAMGITGGAVGLAISQASSLTGMIQFAMRITANISNQLLSVERVLEYKQLSPEPDPTKPKPLPKNWPLSGKIEFKSMKLKYFEDGPTIIKDLSLQIRDKEKVGIVGRTGAGKSSLIAALFRLANIEGSIIIDGIDTGEITLKDLRSKISIIPQDPVLFSGTLRYNLDPFEEYTDEQLYRALMEVELKDANNIINRLENRVMDRGSNYSVGQRQLICLARAIIRNNRILMLDEATANVDPQTDALIQKTIRTKFADCTVLTIAHRLNTIMDSDRVLVMDQGTVAEFDHPHMLLQNEDGIFTNMVEETGKAVSDQLKKIARDTYEKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8Y9</accession>
    <name>A0A6P7G8Y9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-induced degradation protein 8-B homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114335288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141303.1">
        <property type="nucleotide sequence ID" value="XM_028285502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8Y9"/>
    <dbReference type="FunCoup" id="A0A6P7G8Y9">
        <property type="interactions" value="2377"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641675.1">
        <property type="protein sequence ID" value="XP_050497632.1"/>
        <property type="gene ID" value="LOC126878778"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G8Y9"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028141303.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17544" checksum="D5EEA23834C007DA" modified="2020-12-02" version="1">MTGKIQEATALINQLHPELLDNDRYLYFHLQQLHLIELIRNNRIEEALAFAQSHLSEAGEEDPSVLSELERTVALLAFEEPLSSPFGDLLAPSHRQKVASEVNAAILKMEHQENTAPQVSTLLKLILWGQDKLTKRNVKYPKMVDLASAKIDDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHJ0</accession>
    <name>A0A6P7GHJ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fructose-1,6-bisphosphatase isozyme 2</fullName>
            <ecNumber evidence="8">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">D-fructose-1,6-bisphosphate 1-phosphohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Muscle FBPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC114342723</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="29">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
            <location evidence="4">Sarcomere</location>
            <location evidence="4">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 24">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028149314.1">
        <property type="nucleotide sequence ID" value="XM_028293513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHJ0"/>
    <dbReference type="FunCoup" id="A0A6P7GHJ0">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653122.1">
        <property type="protein sequence ID" value="XP_050509079.1"/>
        <property type="gene ID" value="LOC126886254"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GHJ0"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000005">
        <property type="entry name" value="Fructose-1,6-bisphosphatase isozyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006779">
        <property type="entry name" value="PRK09293.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="17 24" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="25">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="26">
        <location>
            <begin position="213"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_028149314.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38655" checksum="26528871F00F46A0" modified="2020-12-02" version="1">MYVVNDGSRFVTERRMESNTITLTRFFLAEQQKFPEATGELTQLLTSIQTAVKVISSAVRRAGITKLFGTVGETNVQGEEVKKLDVLANELFINMLKSSYTVALLISEENETILEVETEHRGKYIVAFDPLDGSSNIDCLVSIGSIFAIYRKSDNTVPALDDTLMSGRNVVAAGYALYGSATMLVISSGSGVHGFMLDATIGEFVLTEHNMRIPKKGKIYSINEGYYHEWDDAIREYVDAKKDPSKGKAYGARYVGSMVADVHRTIKYGGIFLYPATKSSPKGKLRLMYECVPMAFLLDQAGGLATDGKINILDIKPTNHHQRSPIFLGSIEDVEEVQSYINKHCECKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHR3</accession>
    <name>A0A6P7GHR3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC114338983</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1. Interacts with TMEM41B. Interacts with SVEP1. Probably interacts with PEX11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145412.1">
        <property type="nucleotide sequence ID" value="XM_028289611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHR3"/>
    <dbReference type="FunCoup" id="A0A6P7GHR3">
        <property type="interactions" value="2007"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289611.2">
        <property type="protein sequence ID" value="XP_028145412.1"/>
        <property type="gene ID" value="LOC114338983"/>
    </dbReference>
    <dbReference type="GeneID" id="114338983"/>
    <dbReference type="KEGG" id="dvv:114338983"/>
    <dbReference type="CTD" id="38199"/>
    <dbReference type="InParanoid" id="A0A6P7GHR3"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="18">
        <location>
            <begin position="343"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="20">
        <location>
            <begin position="632"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="19">
        <location>
            <begin position="823"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="852"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_028145412.1"/>
        </source>
    </evidence>
    <sequence length="1228" mass="139582" checksum="B5C897372D266149" modified="2020-12-02" version="1">MLTKFETKSARVKGLSFHPKRPWILTSLHNGCIQLWDYRMCTLLEKFDEHDGPVRGICFHNQQPLFVSGGDDYKIKVWNYKQKRCIFTLLGHLDYIRTTLFHHEYPWIVSASDDQTIRIWNWQSRTCICVLTGHNHYVMCVSFHPSEDLLVSASLDSTVRVWDISGLRKKNVAPGPAGLEEHLKNPGATDLFGQADAVVKHVLEGHDRGVNWASFHPTLPLIASGADDRQVKLWRMNDSKAWEVDTCRGHWHNVSCVLFHPRQELILSNSEDKTIRVWDTTKRTCLHTFKRENERFWIMASHPNLNLFAAGHDGGMVIFKLERERPAYTVHGNLLYYVKERYLRKLDFTTSKDVPVIQIRGGGKIPVYKMSFNPAENAVLLSTRTSNLDNSTYDLYVIPKEQERDDQVPDLFFLLEAESKRSSGLTALWVARNRFAVLDRTHQLIIKNLKNEVTKKVQTPTCDEVFYAGTGMLLLRDSEHVTLFDVQQKRTLAQVKINKCRYVVWSSDMSHLALLSKHNVTICNRKLDVLCCLHENTRVKSGAWDDTGVFIYTTSNHLKYTLKNGDQGIIRTLDLPIYITRVRGNQIFCLDRECKPRVLTVDSMEYKFKLALINHKYEEVLYMVRNSKLVGQSMISYLQQKGYPEVALHFVKDDKTRFTLALECGNIEIALDAAKSLNDKACWDQLAHAALWQGNHQVVEMCYQRTKSFEKLSFLYLITGNLDKLRKMMKIAEIRKAKSSQYHAALLLGDLEERVKILKASNQLSLAYLTAATHGMVDEAEQLKEQIGEKKGFPDVDPNAKFLKPPPPIQQAESNWPLLTVSRGFFENTAAVATASANMKSLMAEPVADMGMEEAPGWGDDDELELDPEEKKAEAAAGGGDGEGGWDVEDEGLEIPDLGPSVPVEAEGNFVHLPTQGPSPLVTWTKNSQLVADHIAAGSFESAARLLHDQLGVVDFKPYESLFISLYSSSRTVYSWQQNIPPSFSYPLRNWKDANVKNQLPASGVKLNELVAKLQACYQLTTGGKFTEAIEKFQTLLLSVTLVVVENKQEISEAQQLLRICSEYICGLQMETLRKTLPKASHEEQKRQCEMAAYFTHCKLQPIHQILTLRTALNMFFKLKNYKTAASFAKRLLELGPRPEVAQQARKIIQACDTNLTDELQMQYDEHNPFNLCGHSYTPIYRGKAEEKCPLCGTSYLPKYKGTLCNVCRVAEVGKDCIGLRISVHQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHY2</accession>
    <name>A0A6P7GHY2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114342872</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028149481.1">
        <property type="nucleotide sequence ID" value="XM_028293680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHY2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293680.2">
        <property type="protein sequence ID" value="XP_028149481.1"/>
        <property type="gene ID" value="LOC114342872"/>
    </dbReference>
    <dbReference type="GeneID" id="114342872"/>
    <dbReference type="KEGG" id="dvv:114342872"/>
    <dbReference type="InParanoid" id="A0A6P7GHY2"/>
    <dbReference type="OrthoDB" id="6723085at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028079813" description="acid phosphatase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028149481.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45490" checksum="B6B0C1DA313A16DF" modified="2020-12-02" version="1">MFRQLQLLALLFSAAFAASDLSDLDKAASDQLVAVVQLFRHGHRTPTEFFTNDQYSDLSKYWGGVDLGQLTNLGKQQHYELGQFTRKRYSKWLPKRYDKADFYAQTTDVDRTHMSGQTNLYSLYPAKEDQVWRRQTDWQPIPLHPADSNIWETFPSCAAYTTELAKVLASDLYKAIDKQYAEVYSYLSRYSGENITTLSKVYPVFDSLKSESTAGLRLPRWASKIYPEPLTQLMGYYFHSMVFTTKQQRYFSGTLLNSILNYFDNKINGSVTQQFKMYSGHDTNVAGLLSSLNAFNPPSPPEFASSVYFELRNISGYYFVNVWSKDGSNFKEVSIRGCALDCPLNEVRQRLNEIVLDVDTRTEECSAETTFETLAAKNMYNKLIETGEIERLKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GM64</accession>
    <name>A0A6P7GM64_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114344088 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114344088</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQ65</accession>
    <name>A0A6P7GQ65_DIAVI</name>
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        <submittedName>
            <fullName evidence="9">UPF0669 protein C6orf120 homolog</fullName>
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        <name evidence="9" type="primary">LOC114339452</name>
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    <sequence length="191" mass="21436" checksum="DB41E5AC86210C31" modified="2020-12-02" version="1">MIHLIFKLLSLLIFSRADLEDGTNAYSNSEVLGYTEGVVGNESFVYYYIHHSGNIVLSLSSSVGDADMYISDTQVFPTYYPDTYDLHSATCGTDNVEIPLNFKSPIAVGVYGHSAHEVSNFILQVLKNPEADRAFAIIEDELPQEMKDSIQVPNEIKFKNVKQKIKKKHHQSAQRPSGFESLFEIIGLIFL</sequence>
</entry>
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    <accession>A0A6P7GRU4</accession>
    <name>A0A6P7GRU4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Two pore calcium channel protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">LOC114340021</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TPC1_animal"/>
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    </dbReference>
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        <property type="entry name" value="TWO PORE CHANNEL PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="119"/>
            <end position="137"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028146535.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="93191" checksum="D39005C1766BC305" modified="2020-12-02" version="1">MQPAQRSVNRYDLIKGAFLTAVNVLMASTSRGSPDDDGYKRFTEDIHNVSYGSNTSNPIDEMGSRSSLSRDDIGDMDQWEMNFHEAAIFLEEGANNEKFDSHPRHPGALPAYLLVHNSWYYGFDLFFSLVLLMLAMVEQPSLDTFEFPVAIHSTLELVALGVIGVELMLKLRWIGWRTILKHKRTMVKCVTLSIMVLEAIAVLVRQSSHFRVTRALRPIFLVDTRACGGVRRYIRQILQSLPPILDMLGLLMFFVCSYALLGYFLFSGHETNLYFRTLGDSFVSMFVLLTTANFPDVMMPSYAISKWTAAFFISYISTVLYVLMNLMLAVVYETFTGIEKDKFRKLLLHKRQACKLAFRLLVSKQTPNHIRFKQFHGLIRYYAPKTRLRDVVLMFRQLNKSNSGQLTQEEFLNVYDSLTLRWRNKTPLDPWFSAAWPPLRAFCRAAKTLVTWPFFEHFVYVLIIANGVAMFVRVMQNSDSLEEGAKLFCASWDTYFFLILFLMEALLRIIGLGWAEYISSGWNIFDLSVTLSALIGAFLLSMLPNLTAVVILRPLRLLRLFKLKKRYRDIFGTLVLLSPLMWSTGIVMMVMYYFFAIIGMELFSSYNLKNCCENSTVEDFYKSNGTSSGIGYYYLNNFSNLLTSGVTLFELTVVNNWFIVMDAYAFQSKNKFSRLYFMMFYLFTMVVLTIVVASVLEAFRFRIQYKQQTSKKDEELMLHEEVIVDWNSLQSQVQEVRLLESLQTDFVVGGVVSYIGRRRRTREVLQHHMYDIEIKQWLEEAEQNERDDINLIIEEAQMNARLISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSI4</accession>
    <name>A0A6P7GSI4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FRA10AC1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114346198</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152781.1">
        <property type="nucleotide sequence ID" value="XM_028296980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSI4"/>
    <dbReference type="FunCoup" id="A0A6P7GSI4">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296980.2">
        <property type="protein sequence ID" value="XP_028152781.1"/>
        <property type="gene ID" value="LOC114346198"/>
    </dbReference>
    <dbReference type="GeneID" id="114346198"/>
    <dbReference type="KEGG" id="dvv:114346198"/>
    <dbReference type="InParanoid" id="A0A6P7GSI4"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028152781.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="28366" checksum="A930A892C257C8CF" modified="2020-12-02" version="1">MAKILSQMRYLTPYDVHKMLINDYILKRPGDTSLLKRDSSKDKNDYHVIAENHKFLWEEDDPADTWEQQFAKRYYNKLFKEYCIGDLSRYKENKIALRWRIEKEVISGKGQFICGNKKCNEEADLRTWEVNFGYMEHGEKKNALVKIRLCVDCSKKLNYHSKKKEVKRLNKKKYLPKINKLKDASTSSAAVETMEPTESTAIEEVVDSTPADESPWENHKPVEQKSREEEMEEYLQDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H173</accession>
    <name>A0A6P7H173_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114345617</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152217.1">
        <property type="nucleotide sequence ID" value="XM_028296416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H173"/>
    <dbReference type="FunCoup" id="A0A6P7H173">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663436.1">
        <property type="protein sequence ID" value="XP_050519393.1"/>
        <property type="gene ID" value="LOC126893352"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H173"/>
    <dbReference type="OrthoDB" id="10045676at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028152217.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11761" checksum="4488A4CFD27F5AD9" modified="2020-12-02" version="1">MFVTRILRPAVVQNVRFMSQLGDLGSGAGKGGGGGGSIREAGGAFGKQEAAREEEYFYKKQREQLQKLKTDLKDEISFHEEQIKRHQEAISRHKNRVTELDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H992</accession>
    <name>A0A6P7H992_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114345864</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028152475.1">
        <property type="nucleotide sequence ID" value="XM_028296674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H992"/>
    <dbReference type="FunCoup" id="A0A6P7H992">
        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662666.1">
        <property type="protein sequence ID" value="XP_050518623.1"/>
        <property type="gene ID" value="LOC126892858"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H992"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="170"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="357"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028152475.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="64165" checksum="D780DE97D932BCA7" modified="2020-12-02" version="1">MTYPQNGDDGYQARSNGFSNFKSGGNSGGGGGYNNRNGGGYNKTGGGFNNGRFNNSFGDNSYNNRNGGGYQNNFNRNNQGYGGNGGLRQVEWANKKLRPVEKHFYVPHPSVASRTPFEVEQFRKAKEITVEGEAPNPIQNFDEANFPDYILTEVCNKGYEAPTPIQAQGWPIAMSGHDMVGIAQTGSGKTLAYILPAAIHINNQPPLNKGEGPIVLVLAPTRELAQQIQEVSNDFGRSTNIRNSCIFGGAPKGPQARDLQRGIEICIATPGRLIDFLEKGSTNLERCTYLVLDEADRMLDMGFEPQIRKILSQVRPDRQTLMWSATWPKEVRKLASDFMKNPVYINIGSKNLSANNNIVQFVDVCQEHEKERKLGSLLQEINTNADTGSKIIIFVETKKKVEGITRSIRSIGWSALSMHGDKSQQERDYVLREFRTGKSSILVATDVAARGLDVEGIKYVVNYDYPHSSEDYIHRIGRTGRSDSAGTSYAFFTPSNYKQARDLISVLNETNQAINPKLTEIAGKTNSYGKGNSRWGNGGGFNKRFNNQGGGSGGGGYRKFGNNSNNYSNGSTGYSNGFNNGNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HCC3</accession>
    <name>A0A6P7HCC3_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC114346885</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153430.1">
        <property type="nucleotide sequence ID" value="XM_028297629.1"/>
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        <property type="nucleotide sequence ID" value="XM_028297630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HCC3"/>
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        <property type="protein sequence ID" value="XP_050506376.1"/>
        <property type="gene ID" value="LOC126884478"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050506377.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
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    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L31e"/>
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        <property type="entry name" value="Ribosomal protein L31e"/>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L31E"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028153430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028153431.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14323" checksum="DAFB229713C86859" modified="2020-12-02" version="1">MAKQKGDKKGKSAINEVVTREYTVNLHKRLHGISFKKRAPRAIKAIRQFALKQMGTPDVRVDTRLNKQLWSKGIRNVPFRVRVRLSRRRNDDEDSVNKLYTLVTYVPVATFKGLQTENVDASQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HHP6</accession>
    <name>A0A6P7HHP6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Collagen alpha-1(I) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC114348903</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10 11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155165.1">
        <property type="nucleotide sequence ID" value="XM_028299364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028155170.1">
        <property type="nucleotide sequence ID" value="XM_028299369.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028155174.1">
        <property type="nucleotide sequence ID" value="XM_028299373.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299364.2">
        <property type="protein sequence ID" value="XP_028155165.1"/>
        <property type="gene ID" value="LOC114348903"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299369.2">
        <property type="protein sequence ID" value="XP_028155170.1"/>
        <property type="gene ID" value="LOC114348903"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299373.2">
        <property type="protein sequence ID" value="XP_028155174.1"/>
        <property type="gene ID" value="LOC114348903"/>
    </dbReference>
    <dbReference type="GeneID" id="114348903"/>
    <dbReference type="KEGG" id="dvv:114348903"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000007">
        <property type="entry name" value="Collagen type V alpha 3 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044651089" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028155165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028155170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028155174.1"/>
        </source>
    </evidence>
    <sequence length="1540" mass="152758" checksum="7231632473012277" modified="2020-12-02" version="1">MKLNLYLWAVLLALTLVSTKIEAGTRRKHSSKSKTKAQSDDPNSIQPEEVQNQDPSEFEEYGKLDDYEDYYDENETRRPAAASVSYPSTPAPITTPQPENERPRNRHPERTTEIFVQPENERPTQRPTGSVNVHVIPPTERTYTCTQDNREYQDKEKWKVGECTECACVRGRTECTTDEACLQTLNSPQSGPQGEHGETGEPGRPGDPGMPGNPGTPGIPGAPGPPGPLPDLSAFYQQLSQSQGGDKGPNYPEPFQYLQAQVGPVGSRGPPGPPGPVGPQGFQGLRGEIGEPGPAGPPGPAGPRGLTGSPGKDGERGDDGEAGAAGATGPPGSRGIPGMPGLPGVKGHRGFPGLDGSKGDQGSTGEKGSQGVSGPMGQTGSQGPAGPRGERGREGPPGPPGIRGIDGIAGPPGMPGSIGKPGAPGFPGNPGAKGDQGASGPKGSQGYQGSRGESGRPGSPGESGPPGPAGKDGLHGEKGNTGAPGIVGPPGFPGARGPPGLAGSSGQPGAKGADGLPGERGYRGEPGIKGEIGSAGPRGLPGVSGPEGKRGKRGMRGSPGPQGLTGERGIAGVRGLPGPDGAPGPKGQAGARGGTGPAGPKGPEGEAGRQGSPGLQGIRGVPGRTGAPGKPGPSGERGIPGQDGKPGEAGPQGIQGLPGPLGMPGERGLTGEPGKDGEAGPLGPAGPRGDAGKDGNPGPQGLPGPPGVDGERGAPGVDGARGFQGLPGAVGNPGSPGKDGEQGVQGPIGVSGPQGQRGERGFPGERGLPGISGLPGSKGATGAQGADGPLGPDGPPGPKGHPGLPGAIGLPGLRGAPGSQGEKGEHGSVGPIGPDGAPGRQGERGPMGPLGPPGSPGEPAAPGEPGPQGISGEPGAPGASGERGPSGPQGVQGFPGPPGLIGLPGIKGERGFNGMKGAQGNSGLPGKPGEPGPQGPIGLTGAKGARGEAGQRGDAGIMGAPGRPGEQGPAGLPGNAGPSGPQGIPGIKGATGDIGRSGLPGPQGLPGAQGPEGGRGERGNEGAPGPVGPIGPQGPSGERGIPGFPGPPGPIGSQGTRGSPGEVGPAGKPGNEGPPGPQGMPGPLGPPGSSGDQGPEGPSGKPGLPGISGRPGDKGPQGLPGPPGNVGTPGLPGPQGPAGQAGLAGERGPRGEQGPAGQDGAPGERGKQGAPGQQGSKGDRGEMGLIGPKGHAGLMGLQGLPGAQGAPGERGLPGERGLPGKDGESGSRGPPGREGSSGPQGPMGSPGSRGESGKDGRPGPPGAPGPAGPPGPPGEGMGYDAASLAALLAQGQNNQKGPDSMNDQPPRIFGKELTAEETRELIDKAYEQLKSSFEKLRKPNGQKNSPGKTCRDIKAAYPDSQNGQYWVDPNEGDIKDSILVYCNMEQRATCILPSPVRTPEVNYKGREPEIWLGDVNHGMKITYKADSTQIAFLHLLSSKASQNLTYHCKKSAAYFDATRHTFRRGIKLLTWNDIEVTPKGKLKYEVLSDECRYRRNTWEQSVITYSTEKPQRLPIVDIAIRDVGEQDQFFWVEIGEVCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IB15</accession>
    <name>A0ABM5IB15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxidase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128941.2">
        <property type="nucleotide sequence ID" value="XM_028273140.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128942.2">
        <property type="nucleotide sequence ID" value="XM_028273141.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128943.2">
        <property type="nucleotide sequence ID" value="XM_028273142.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128945.2">
        <property type="nucleotide sequence ID" value="XM_028273144.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506043.1">
        <property type="nucleotide sequence ID" value="XM_050650086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506044.1">
        <property type="nucleotide sequence ID" value="XM_050650087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506045.1">
        <property type="nucleotide sequence ID" value="XM_050650088.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273140.2">
        <property type="protein sequence ID" value="XP_028128941.2"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273141.2">
        <property type="protein sequence ID" value="XP_028128942.2"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273142.2">
        <property type="protein sequence ID" value="XP_028128943.2"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273144.2">
        <property type="protein sequence ID" value="XP_028128945.2"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650086.1">
        <property type="protein sequence ID" value="XP_050506043.1"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650087.1">
        <property type="protein sequence ID" value="XP_050506044.1"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650088.1">
        <property type="protein sequence ID" value="XP_050506045.1"/>
        <property type="gene ID" value="LOC114325165"/>
    </dbReference>
    <dbReference type="GeneID" id="114325165"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF125">
        <property type="entry name" value="GH11385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028304" description="Peroxidase-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128945.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="82690" checksum="00D8F25EF17852CF" modified="2025-10-08" version="1">MNQLGVICLINLILVQFSQAILLPPFKLKQSHPNIRSNNFHLSKKEIEDAVQVAKRFTSYLEKFEETIQWPSRIVEGTPAHGLFISQAPKWKGIERGRHALLAIQASAQLSYYCHEEKEISLDKCSDILLHYNFYNSSLEDSCKHLQRNCTTVDELSGFRSINGSCNNFNKGSLGESYTTFERLLPAVYLNNYDAPKRSLTKAALPSARKISTAIISNEPNPHESLTMAFNQFGQFIEHDLSNIALSVMIHRNDSFTCCGTDGYEIAPRYKHPLCMPVKISSDDKYYSKKYVQCMNYVRSLPAMRPDCSIGYLEQQNQATHYLDGSQIYGTSDEASWELRTKEGGKLKTSKNNFPSLSNKPQQHCGAKSEKDVCFISGDQRVNLHPQITVIYTLWIREHNRIAEELSRVNQHWDDERVFHEARKIVIAEMQHITYYEWLKNLLDIKYLTMIEKFSKYRDDIDPSVSNAFATAAIRSMYSMHAENISLVDHNQKEISALAHHKYYNKPEIVTKHKHFDLILKGISNQAAQKISNFYSNELNSMFLADDNYGYDIVSLDIQRGRDHGLPGYNDYRKLCGLPKASNFKDFMDVMTNNSVNILSKQYKHVDDVDLLIGGLLEKPLQGSLVGQTFSCMLADQFVRSRRGDRYFYLNSQQPKPFTHLQLSQIKKITLARIFCDNSDIATIQPNVFEKVSSSNKLMNCNTSDQIPKLDLSVWTDSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFR9</accession>
    <name>A0ABM5IFR9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131765.2">
        <property type="nucleotide sequence ID" value="XM_028275964.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275964.2">
        <property type="protein sequence ID" value="XP_028131765.2"/>
        <property type="gene ID" value="LOC114327370"/>
    </dbReference>
    <dbReference type="GeneID" id="114327370"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045234283" evidence="2">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131765.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="22910" checksum="3AF651FC468E1A7E" modified="2025-10-08" version="1">MKVFCIFLSVLLLASAYKLKGSADPPEFHHVQARMALRPGCYYRLICDHPPPEFHPHVIPPLDGARSKPRLTRDTELGIARFKRIPPPSPYPWCYHIVECNDELKQKIDEIPKDTNAENHSHSQDEQAKKIDLEKNSQTSEKPENKNSKRQTEEELEGSRATAVAEAQSDGGYAKAYASASARAISHQNKYCYYCKIIDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIX9</accession>
    <name>A0ABM5IIX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133859.2">
        <property type="nucleotide sequence ID" value="XM_028278058.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278058.2">
        <property type="protein sequence ID" value="XP_028133859.2"/>
        <property type="gene ID" value="LOC114329046"/>
    </dbReference>
    <dbReference type="GeneID" id="114329046"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133859.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="107" mass="11992" checksum="6816ED11EF3E7C26" modified="2025-10-08" version="1">MAFRVPTPNVSVVDLTVRLGKPTTFEQIKDVMKQTSKTTMKGILGYTEEQVVSTDFNGDSHSSIFDAKAGIALSDQFVKLISWYDNEYGYSCRVIDLILNISTKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJF0</accession>
    <name>A0ABM5IJF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DENN domain-containing protein Crag</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134195.2">
        <property type="nucleotide sequence ID" value="XM_028278394.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278394.2">
        <property type="protein sequence ID" value="XP_028134195.2"/>
        <property type="gene ID" value="LOC114329338"/>
    </dbReference>
    <dbReference type="GeneID" id="114329338"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="5">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="187"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1055"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1413"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134195.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1605" mass="180280" checksum="71C3AC138C3EB063" modified="2025-10-08" version="1">MDDRRVADYFVVAGLPEIPETLDETTLSEGGSLKASHGQPPITDISVIFPSLGEVKPDDFEVISKTPTGLSADLNHGSIRTIECFLCIKRGRDKPPLVDIGVMYEGKEWLMEDAEVVKQSVGGNIANVNNSASQTFITYRRGPKSMPCNALVVTDVCVVIASKGESPPHAFCCINKNLNKGLVGSDVFLCYKKSMNRATLLTYKPEVLSRYPLGDLPEFPFPDSVPLFCLPMGATLEMWPKEATQPKPVFSTFVLTVSDAKHKVYGSAVTFYERFSENKLTQKQTELLNYEEDSEFALHANKSICVLSHWPFSEDFEVWLRWLHGIATSGKPQPIPIERYITQLLDEVQFPSPRILLQMSPHNSKDRVILTQPEDLPLPRSAASFKHLLINLGPENCLQVLLLMLTEQKVLIHSLRPDTLTSVAEAVSTMFFPFKWQCPYIPLCPLGLVEVLHAPLPFLIGVDSRFFDLYDPPTDVSCIDLDTNIITVAESQRQNLNIKLLPKKAAKILKSTLDYLYYQLRNNTTNNTSDANVQDDIELEFQRRKKQQSQELEIQEAFLKFMVLSLKGYRSYLLPITKAPTVGTTDPEALFQLNDFLKSRDKVNHRFFTLVMRTQMFIRFIEERSFVADGDQGLAFFDDCIEKIGHEENNSFRLIELDSVHKSDRTVFVLPPEPTAPGEMYEYKHFNLRASLLIGHGKRKNPLSSLFQTITPGSPMARRTKQEIKSAQKLARKCLRSPDLWARCLCGTCHTLYFMILPSMLHLNAGKEKAILQQSYELLVKATKLRLTCDEVCYRLMMQLCGEHSRPLLAVKLLVLMKKFGIQPNALTYGLYNRCVLEAEWPAHSSSSQLLWNKLRNVVIGAAHFKWAVRKKAIHMSASTEGGSSLLDQTDRAISRSSLDSHEAIREDHPPLLRRGTSIIKGSLNGLEEVDGLETINGSEHEEEQEAEDTLKQNGDIEDEKSTEKEQTEKKIVPTPDSPSEYRLLSRSESAADANLLDQIQANNKRSCSKALNFNNNGTDEKEEIEYGDNENNSPGKVSREVITENDPLGAFTVPLEEATSTQPSQTADSSYTRNSTNLSIEPVLFRSSVQRSATFEGSPPSQSKLQRSETVPAATVASSLASFGSSLKLGFSRYSPSRLSLRKADLKMPHQFIENAFNNFGPSSLTSKKPNELIQGGLSSIKSAATTMVKKMEEIKEAISTSTNSTPVKVLTGDRLAAGDAPEGAEGDSNDGSDCGDRHRKISTEMSSYRGSVTNLKEYDESLPESLFPMPKEDKTESELDITLTTCSQCHNCSCLLYDEDIMANWSPEDSNLNTVCQNCNKPTVPFLTVSITGPDIEPCDPFSIPYLNPLVLRKELENILTQEGDLCLSDSKFVDDHPIIYWNLVWVFERINVQTHLPNLYLRKKAYSENTGSSNNNVENGDRLSGGTTSMEPVEEGTDPLTQELTALADPKEKETQLAAQVHLRCHWDEPGLHIDGPPMYMLWKMRDTSQFNSNGRSLITKTFMQQIINYIRVSDLAEPVRTLSKDRKEDENNKCNSIYRDILFLACKVLGRAQIDINTFDKEYAAAYSRATERQYKLYPQDKPISLSALYCRQYFRPLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJV5</accession>
    <name>A0ABM5IJV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vitellogenin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134499.2">
        <property type="nucleotide sequence ID" value="XM_028278698.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278698.2">
        <property type="protein sequence ID" value="XP_028134499.2"/>
        <property type="gene ID" value="LOC114329553"/>
    </dbReference>
    <dbReference type="GeneID" id="114329553"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF33">
        <property type="entry name" value="CROSSVEINLESS D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047479107" description="Vitellogenin-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="5">
        <location>
            <begin position="22"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="6">
        <location>
            <begin position="1480"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1716"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1716"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1729"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1749"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134499.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1847" mass="210559" checksum="5F0DDEA330A387AC" modified="2025-10-08" version="1">MWSQVVLCMLVGLAYATNTPSWTDNQEYVYQVRGRTLTGLMDVSDEYSGIFLKSKLRIQTRGDGKLQGSIENPQYTQIHTTLDDGWDAEVPEEELSWKPLPMSSKPFQIQMENGKIEKLILNRDLNNWEANMIKSIVSLFQLNTNGENTLPSPLNSLPEHGSNSGVFLTMEDTILGETETLYKIRPVPEHTLLSNEKEARFVELKQKRQQNGDLIEVIKHEDFTNNRELPAYVYGFGDYLLPNKAATNQMGTYFSRDSSSRAILAGNLNHHDVLFTSTKNTILISPSVNDEQKGAVYSYLEATMEDVKSGTQKIGEVNQAVHLENLVYSYNQPFSKDNHVEGDENQNQRNQRTSDAYRYSSGEEEYEDRDSYKRLSHRRYQRSLAKKYGPKNDNSEENLQNQPRINEAPESPLLTLTTGYKGMSIKNSVNVVKEAEKLIKKIASDLQDQEKDHHEKTLERFVNLETLMRLMNFDELKQVSDKVMRQSRNAQEAATSAVTRDVIAQTGTGPALLVIQEWIQEGKIEGEEASQVVIVAFSSVRLPTMEHLRTAFKLVKHQKVEDQFPLNNTALTGFTDLLRKAVIQKNVAKSEYPVNSFGRFRTEESKQFVREEVMPYLKEKLQKAVQRAETHRIHAYIRAVGNLPDPRILEIFEPFLEGKQQSSQFQRLLMVLAMGKLTETHPEDALAVFFRIYQNPAEHQAVRIAAVFHIMRSRPTPQILQVMASNTNNEDNDYVNAVVKQSIEELTELEAPEFAYIRSIAKGAQPLLTDKEFPAQFGGNYIRDYVIEELNTLYKTSTQIIPSKDEYVPKGFRYTMRANFNGLYQKLINMQAIVSSVDDLMAVAYQKTQSFAEQQQQQQQRAQEQLNNPWSSQNIAKLLNLKAEEREQLEAYWYLELRGTPVGMYGFDNTTMNQLPKLLSTMESAMSKGKQINLFKLINDQEMAIAVPTAMGIPFLYTYDSPMLVKVQGQVGGQVKPQLVQNQKIQTPENIQLQATIRATVSGKTQGRVTVIVPFEREQYISGYDKHWEANTPKLSIQLNVNLEKQEVKAEVELKPEGKEGKVKFLHFRSWPYTAKSDVTDLEPLSAQKSTREIVPDNMHAFKTTVGQKSVGLALEVEVKHERKFIHSELINRLFSQNGVIDGAKALWDVNILQSSEINVNLDAEQSSVRKIILRSRYDQDYQQKGESPKSEYRLNEKMSQSQRQQEIMDAVASGINSVSVNSLDTIIELKGEKTIQYLLTGAVAKSNVDPKSNVRICFKRSSQDKELKDYEAHFVSESMIPNTNALDLQYSLSKNEPKIDTKMQLVFGPSKESKKSKIVAEIKHRRSEERKQYLKELPLYEQCKQEMKESNKQLFSCTNLTMDSNLLDRIEVKLQSQNLKPELLEAIEMTYEAARFELLPSLQIKNKQQSVQPNSAEMDIKFHPDLSFVNVTVRTQNQKVSAKNIEVNDNVRIIAVAHPVFNLRDRVLSKLLGGDTFRDFCTVDRSAVNTFSNRTYDAELSNKWTVMAQYIPKLPRQSGQQQPQESAHKQLQNQLENYVVLVRQSKQSGKKELQIVLSSPRSDFETISILLEPNQGQQSKARVSVNGQKIQVNDKQSNDIKDGYIQIYELPNGEVKAEIDGVFYVIYDGERVRMTAVNGKMKNAIRGICGQFNDQDSEDFLTSETCIARKPHKFVKSFEVEGDEGKQVRKEFAGSSSQCVEMQVPLYINVITDENARRNSQDRSSKNSQYYSGKSSYRGSSRVSSRGSSRDSSEKGSEEDNDCLFHQTRYVFQGGKICFSTKPLPSCRSHCQPRDQRKKSVGVHCIQKSDVAMLWKKQVDKGNSPDFSQKKEHTTLKFEVPESCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJX7</accession>
    <name>A0ABM5IJX7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134545.2">
        <property type="nucleotide sequence ID" value="XM_028278744.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278744.2">
        <property type="protein sequence ID" value="XP_028134545.2"/>
        <property type="gene ID" value="LOC114329587"/>
    </dbReference>
    <dbReference type="GeneID" id="114329587"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="713"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="807"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="897"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="943"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134545.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="979" mass="109105" checksum="329C7C1B39421E3E" modified="2025-10-08" version="1">MVVVTHTDICIPITFWKESFRGRLHIRYIMPSARLTLREEDVVRLALEFLYNRQLHISQLSLERETGVINGNYSDDVLFLRQLILDGQWDDVLEFIQPLEALKSFNMKKFNYTILKHKYIELLCIKSEANIQGNSMDNAVEEVVSILNELEKYSASKEEYSTMCLLLTLPRLSDHLQYKDWNPSNARVQCFREVYPLVAEYLLGDKKPTDGNANSSAQNDRLIQLIIKGILYESCVNYCQAKATGSTDSQSQDMNFSKLLDGSVGFSDSDLSLLSWLQSVPSETFSVPFEQRTLNVDVERLERPSLETSWTEHMLITPIKPKTFPHSAMPFTRPRSAADIMSRSLMLPMGDGLQFAQNNNMSTSARMMVLSTGDIGLNRPMSRSSFASFHLTGLKNSRNMNASVDRLFENEGDVFLSNSYGDFQQHMPSIQEQTSTPKPSANNTLPSCPKNPIVDRKSNTSTPEPKDRESPAPTGTEMTPRPDYYDSRAAAQPVIFSSCAAANTEAGAIQPIDHNYSGELVREFHRTKQKLQEALVQREKEREELIKQINSDNQKFSGDSKQGGSSANINNQGIHHLDSSINHPNLSNGNLVTRGKPPTTKPLNGTNLSSYRGSLEDTTLRHVIEDQPVPHTPPHGSPRQDQDNGIESQRPKFVAVTTLEDVQAVRCAEFHPGGQLYAVGSNSKTLRICAHPKLLDIREDHETYQPTVLFKRTKHHKGSIYCLAWSPIGDLMATGSNDKTVKLMRFNADTNNLEGDEIELTMHDGTIRDLCFLEDQSNKSSLLISGGAGDCKIYVTDCATGTPFQALSGHTGHILSLYTWGGAMFVSGSHDKTVRFWDLRTRGCVNVVTPITVPGSRQGSPVSTLCVDPSGRLLVSGHEDSSCVLYDIRGGRNVQCFKPHSSDVRSIRFSPSAYYLLSAGYDNKLVLTDLQGDLTLPLPSVVVAQHQDKVISGRWHPAEFSFLSTSADKTATLWALPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQJ1</accession>
    <name>A0ABM5IQJ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138854.2">
        <property type="nucleotide sequence ID" value="XM_028283053.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283053.2">
        <property type="protein sequence ID" value="XP_028138854.2"/>
        <property type="gene ID" value="LOC114333201"/>
    </dbReference>
    <dbReference type="GeneID" id="114333201"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138854.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="267" mass="29290" checksum="DBFCB688E1B47C07" modified="2025-10-08" version="1">MLLEPIANTITSVEGDTPTISKCLHLFKKMVNTSLENVTKSPLLSKEEADTRAIFENRKKFDIYSVHFVANLLDPKYRGCELSSDEMTDATEVIYKVAQKMPDVDEAAVLADVVNFIAKGLFKKAFLWNEDTIAAISPIAALSKLAIHFLELPATSAACERSFSSYSGIHTNKRNRLTNTRASKIVYVAHNLKLMAELQPSESSSSESIAGPSFTVNPALESEPEPMIISNSDQSESVFESDEEEASESEENADSDGTDQCSFKGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IX43</accession>
    <name>A0ABM5IX43_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146387.2">
        <property type="nucleotide sequence ID" value="XM_028290586.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290586.2">
        <property type="protein sequence ID" value="XP_028146387.2"/>
        <property type="gene ID" value="LOC114339901"/>
    </dbReference>
    <dbReference type="GeneID" id="114339901"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146387.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23725" checksum="86C324552E9C4F19" modified="2025-10-08" version="1">MNHYCCVPGCKSWVKRNPELSFHLFPKPKKSNVIVETKLGSKELVDRRKVWIQRLKIGKKVSDYMRVCSLHFEATDFLQKQRVKRRTLKLNAIPSQKLPLEAHSTEPGPSSRSITAAAKQRIVTTVAPSLIPCEDVEDLDDQEAAEILTSLKNTENSTLSKDAAVQVNITKEITLCDILDSDFKLKEFTGVDNYVIFNTINADIWKTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH78</accession>
    <name>A0ABM5JH78_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 6a14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497294.1">
        <property type="nucleotide sequence ID" value="XM_050641337.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641337.1">
        <property type="protein sequence ID" value="XP_050497294.1"/>
        <property type="gene ID" value="LOC126878553"/>
    </dbReference>
    <dbReference type="GeneID" id="126878553"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047319820" description="Cytochrome P450 6a14" evidence="13">
        <location>
            <begin position="18"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118160" checksum="66FBA69648DC7652" modified="2025-10-08" version="1">MFLLFILFLLLVIYVYQKWHYSYWKRHGVYQVEPYFLYGNQKEFANGTLCISDQLKKLYDEFKSKGLRYGGYYAFTKPTLMPIDLNIVKHVLQKDFGHFVNRGIYFNKTRSPLSEHLFTLEGDKWKNLRAKLTPTFTTGKMKMMFPILIACSENLKDVVDKHAVLDDAVDIKDIIARFTTDIISSAAFGIECNSLRNPDSEFRKFGRKIFELGKWKHLKRQMGNSVPKWFLDTIQMNPVDHETEDFFMEAVRSTVRYREENNVYRKDFMQLLLELRNNGKLSDDQGVSSVGKNDCNSQFLSLNEVAAQCFVFFVGGFESSAMTTTFTMLELARNQEIQDKLRTEITTVLEKYDQKLTYEGIMEMTYLDKIVHEALRLHPPGSGIGRICNSDYKIPGTDLLIEKGVRVLVPILALHRDPDHYPDPEVFDPERFNEENKAKRHPFAYIPFGEGPRMCIAPRFGVLQTKVGLVTIIKDFSITLNSKTQLPIKYAPNGIVTSVAGGVWLNIQSLEFCFNCMMMYYILVSVAVIYLYLKWHFSFWTRKGVYQREPSFLFGNVSDLLFNKRSIANFVDNMYADFKSKGLKYGGYYEIFKPRFVPVDLDLIKHILQKDFAHFVNRGIYSDPADPLSLNIFSLKGEKWKKLRAKLGPTLTIGRTKSMFPITKACSDQLRIHLKELWLTKGYMDSHEVGARFTSENLGSIAFGIEFNNLKESNLKVLKLCLKNIVGTFATQIKRLICCNFPEHILRRTGYRTHSRELTACFTDLVTGVIDYREKNNIHKKDLMDVLLQLKNKGNITYDGDSTPATQNGVQDEIFLSVNEVVAQGYVFFIAGFETSSTTIEFALFELATHPDIQEKVIKEVKSMLEKSDNEISFEGLKSLTYTEQVINETLRLHPPLPALLRKCNKDYKVPNSDLIIEEGTMLGILVSSIHRDPEIYPDPDVFDPDRFTEENIATRHPMAFMPFGEGPRICIGARFGMISLKVALATIFQDFRVTVNEKTQLPLEYSTKSISTRPQGTIWLNLHPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHD9</accession>
    <name>A0ABM5JHD9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497356.1">
        <property type="nucleotide sequence ID" value="XM_050641399.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641399.1">
        <property type="protein sequence ID" value="XP_050497356.1"/>
        <property type="gene ID" value="LOC126878591"/>
    </dbReference>
    <dbReference type="GeneID" id="126878591"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="176"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35720" checksum="06FCFFFB2AFE14B6" modified="2025-10-08" version="1">MFERKKRTIVGNDDEDLNTLLYFEENSETSLNNATNALEKSRATIHRVLKKHNYKPYKILPVQELTDVHKRKRLEFCQDMLTNLNNDPNYFYNILWTDESNFSTSGLKEFHKGHTVSKIWHDTSIRTPRQAFIEGLSTGLRAPPGKVQRLIAAHIGSDTGFLENSALVFISKKTGDYHEDMDAVCFERWFENVLQHLEPNSVVVLDNASYHSRLVERIPTMSDKKAVLQHWLREESIPYGEDMVKGELIGIIRQHRGKYRQYAVDTMSRLHGITILRLPPYHCELNPIELIWAQITNERICGSGKCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKM7</accession>
    <name>A0ABM5JKM7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-piRNA 3'-exonuclease trimmer-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498492.1">
        <property type="nucleotide sequence ID" value="XM_050642535.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642535.1">
        <property type="protein sequence ID" value="XP_050498492.1"/>
        <property type="gene ID" value="LOC114327428"/>
    </dbReference>
    <dbReference type="GeneID" id="114327428"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF44">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PARN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64919" checksum="F481DAFD6A2BC6CA" modified="2025-10-08" version="1">MFNIIGVLCFVIVVIKINITLKYLKMTEINNKNFEQHFPEIRKALEQAKFVSVDLEFSALYPLKEYSPSLFDTPNERYQKIRKNVKLVVPIQVGLTAFSFNPDTNSYLGTIYNFYIIPASFPFIRKNCLFQSDTLSFLKFFEFDFNKFVYSGIPYMNKDEEQEIRQRFKSNDITDVQSLFRQELETIFHNEGEKIRNWYMTANIGETITIPEFYQVSKDSDEFVYFIHKTIRERFKGVWSSVENDEFVLKKVTIEESIKLNQVCNLEEECIKNLLGFSRVFRYLVSLQKPLVGHNLMQDLLLMLECFEKPLPSSYESFKKTINALFPKIFDTKTILYNIKKQVPEDKTINDKSLKDTFEYFKDGVGRHLALNSPAIENNCNGTYKYHEAGWDSFCAGYIFIRMAYFNLYQKYPKSKRYMSGELIAGLEFCQNKVNVIRGAVSSIQLDGEDPASTRPPYLVVESLKNAPINIHQVSSVLSSFGFVEIRKFPYQNKMALIAVDNFGSARRILQNFKSNKEYQIRQYSALKHSPVIRACLLSGVTISGVILLWITHSIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLF7</accession>
    <name>A0ABM5JLF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498776.1">
        <property type="nucleotide sequence ID" value="XM_050642819.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642819.1">
        <property type="protein sequence ID" value="XP_050498776.1"/>
        <property type="gene ID" value="LOC126879634"/>
    </dbReference>
    <dbReference type="GeneID" id="126879634"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="366" mass="42865" checksum="1D6F7474C72680A0" modified="2025-10-08" version="1">MPKKKCCNRKKKKVFKPVKTFRYLPGSVSNEVNYDDLHTYNCHRYRVLTCHEVVDTKPFSINPFRMLPRRKMVEDLFQSESIDKKNKHLLYKINFINRNGGWVDCYNPWAYWRKNDWLSYEQKMKGYEKENKIIHKTILSSESHYSKSEMDKRWKKVMFNFSHSSKFPLVITLKVDHDAILKSQPSISEDLCICTSKCLRTNRPKCFLEFSVKDGEYLGKIIIELYFDFVPVTVQNFMEICEGKKLTYKNCLVHRIVRGQYMESGDITLCTGRGGTSIYGKTFSEENHLLKHSKAGVLSMKRLPPTDNNSQFIITFAKMEQMDHKNVVFGKIIKGYANLLKVQDYGRKIGKPYVDIIICNCGLVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMT7</accession>
    <name>A0ABM5JMT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050499252.1">
        <property type="nucleotide sequence ID" value="XM_050643295.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643295.1">
        <property type="protein sequence ID" value="XP_050499252.1"/>
        <property type="gene ID" value="LOC114337541"/>
    </dbReference>
    <dbReference type="GeneID" id="114337541"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="973"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1308"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="867"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1341" mass="150471" checksum="5D51F2C1D957A0D8" modified="2025-10-08" version="1">MGNQLVGIAPSQIFPVERYLTDIPNLKFDTSLGSTRFLKVARAESQEGLIVVKVFVIHDPSLPLSPYKDHLEDVRKKLSSAVNCIPYQKIILTEKAGIIMREYIKYSLYDRISTRPFLTNIEKRWITFQILYALHQCHKVGVCHGDIKLENITVTSWNWVLLVDFASFKPTFVPVDNPADYSYFFDTSRRRVCYLAPERFSSTSTTITESSSLIAEANCDSGDLTPAMDIFSAGCALLELWNELHVPFEYSQLLAYCSGKYSPEKHLNKLDDPNLRSLISSMIEKDPTKRKRADDYLAEYRGTLFPEYFFSFLQSYMLIFSSNPILSADDKIMRLKHDINDIFTFLGPMTKSKDNESEKSDGEKVDKGECEGLVIITSLVTSCIRGLHTCSSKLYSLEILLDLASHASDETVLDRILPYIMYLAHDSSTRVKISAINTITKCLDLVTKISRSDANIFPEYILPELAPLATDPNTCVRAAYAKNIATLAEISLRYLEQIQNDWYDNNSTNKQKDEHTFNYELELQALHEMISQTVSALLTDTQSIVKQTLMDSGITKLCVFFGKTKANDVLFSHMITFLNDKEDKELRGTFFECIVGVAAYIGWHCSGILTPLLLQGLTDSSEFVTAKSINAMSSLTELGLITKPSLCELVTECSYFLVHPSLWVRQAVAGFISTAAKTLTILDVQCKIMPKLKIYMKYPLIQIDKPELLLESLVTPIPRNVYDSVVSYNEIDSIFDLLKERRSLRECVNTGKVPTTDFHRDYQPSLKNLFRRLEANGLNETMEEYFLKMSHHLKKINKYKLHLDGRQNRPAEGRLETSSINSSVKSHIYNLGDAQKGDYMANRLHRTNTSGSIDTNINSDWNYSSEVLTRQSESTNSGGPPSRSTSSRPSSPPPDGNNHFNSTDPSSNVSLHERSYIQYRKSNCYIELANLKARQQDHYFEALRNKEWAEQATWRPQLPPPGWRLRGVLVAHLHEHKGAVNKLCVLPDTPYFASSSSDGSVRLWDCAKMEGKNIANRSKQHYKLGSNINGMAVCESGQGLGVICQDGSINILRVDSAGNKMIPVQSRQLNADDDGYAVDVQCLDSGSQSVLVYATLYGSLIGWDLRAPGNAFKLDNGLKSGVITTFCLDYHQSWLMLGTSNGTHAAWDLRFQLPIMTFDHPSGSVRIKKVLSHPTEHSWVMSSIQGNNEISMWNIETSFRQKVLWGSTSPPLSKQGTVNSVCAMLGGCIDRSPFLLAGGTDQRLRFWNLESPSESYLAIPGASDPAGTALSYRSRLIDGTLVIYEEAGTIRKLDRGEEIPRPGPEPPATGHRDCISDIAMCKASQCFLVTSSKDGVIKVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMZ7</accession>
    <name>A0ABM5JMZ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499310.1">
        <property type="nucleotide sequence ID" value="XM_050643353.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643353.1">
        <property type="protein sequence ID" value="XP_050499310.1"/>
        <property type="gene ID" value="LOC126879955"/>
    </dbReference>
    <dbReference type="GeneID" id="126879955"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="98"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="198" mass="22253" checksum="E8B3B30852601454" modified="2025-10-08" version="1">MRTTIYIRAKTLNKLVINRFNVTSKVNILGNCNCYNEPFYQTYSCLTPRSVIFNSPALYQSCRFQGTDIKEAAKDDSKRSEKEIPEKIVLKETLSRKEKLKKAVKEYGSTVIVFHIGISLMSLGTSYLLVSSGLDVASLFKTIGLEEWIKNSNIATNAGTFAVAYALHKVFAPVRITITLASVPLIVRYLRKVGFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JN93</accession>
    <name>A0ABM5JN93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fasciclin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499409.1">
        <property type="nucleotide sequence ID" value="XM_050643452.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643452.1">
        <property type="protein sequence ID" value="XP_050499409.1"/>
        <property type="gene ID" value="LOC114333578"/>
    </dbReference>
    <dbReference type="GeneID" id="114333578"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="CD80-like immunoglobulin C2-set" evidence="9">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin I-set" evidence="8">
        <location>
            <begin position="218"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52456" checksum="FA7F30B16C1D781D" modified="2025-10-08" version="1">MNKELLVLPGQNATFLCRVGVALQYCRIELPGGGGGVNLNKQLSSANGEISYFGNGLDAGQCGVTIHRVEEKHNGPIKCTIGIPSETSESVGVMQLIVGKAPKQPELDLSRGTDSLRVYKINDHLEASCIVRDGRPVANISWFLDNELIDDMGLKMPTVIDLAKENLQSKVQNLSRVLQPSDNGRYLKCVAFHPAYPGGSAETKRQLDVKFPPLPMEEPIDKFGYQIGKEGLINISIEANPKPRIEWSVGGQLIKEGSTDNTGRIEAEAIRDLGRGRYEANLRLAGVNKQDTETDYILTAYNDQGSQTYKIKISTSPEPEGVELGVGAIIGVVVLGLFIILLVSILIFAKVTGRWCFTGSVETRHLGESSDTESADVRPKDSKKPLKLSLIFKKNKDHVASEPTLEARNIESELEPKKAPFPEGDESALVYAELDLVRAEMVPVVKNDDEKTEYAEIVYTQADEGKESPKKSPKKSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNI4</accession>
    <name>A0ABM5JNI4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499500.1">
        <property type="nucleotide sequence ID" value="XM_050643543.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643543.1">
        <property type="protein sequence ID" value="XP_050499500.1"/>
        <property type="gene ID" value="LOC126880020"/>
    </dbReference>
    <dbReference type="GeneID" id="126880020"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="829"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123193" checksum="7EC52D042C56E7AE" modified="2025-10-08" version="1">MSMSVKSKSKCQSLLCLEVELKFIVNIKVHSVVTFHLSSHSNKMFFTIFYMYATLLQRIRLGNLKNKLNGTLNSKNALLVCDESVVLESKRTRSFENLLFRTGERIGCTVVPKQTIHLSQWLAFPKDSSLFPIYFGKNAPKLESPHVYVLVQSMLETYVKHSADILQVENYGELIAWRASDTFDAIIKSDLNKLTRIVHTFSMNNLDINHELRLLRIETVDVEGLPTRIKYDKRFAKENALKYSYAPIYWTKFVDSIKEIYGKIRDTKNPKITIESGKSEEKKVPVSEVKPIKKDGKRSDDKNTLEVGSGDYRRHKSGEHRREKSSEKHKGESTKAETSSKSKEESKHRKTEDKHKIKEESKTDGDNIRKEAREEHKRKEKEAKVKRETATTEETVPTKSSKEGKEKQHKREDKKDPPRKSKSNVEKSLEAAKKSEKLLSKRSSSDKKLVKTAALYEDVDSSPKEKSHKAKDIFGVSSSSYKTDSTTNKQPRIQANGLMKSKNVKPPNILIFADSLLAKENVKSVFINMLNKEKYVIYDLPTDPKQSMWNDSTALVVVCGNVPPNLTSQLLQYLLDGGQLLCLCSDFLYCVLHTFTTAEVREHELVRFSYGQWTQVKMMHHIFCYQASPTKKQFSKESDHSNQSSGNGSSPVAPRTPSAVEIQHNGKDYIIQVQILGTEETWQTPSLLLATVKGGRGRAIFSQVHLEINPDQFEDDENKFKALKDSDQARLEILKDILVHQLGIDCTESKELEYTPGYFLGRHDLKLKLLTECKDIKDMRLENSKIVLKFCGKDEKPDQATSNFMPIFIHTCPSNFSTVTYFEALATDEIGRLVIYSDVIAGSQTLLEKNLTHGLVVIPRQQSHGVGRSNNRWISSMGSALFSLQIIISLNSPLGKALPLIQHMAMVAVVSAVKKAAGDSELDIGIKWPNDLYVDKSVKVGGLIVSSNVEGETAGINIGCGVNLDNANPTTCINDLIRKRNEAKGTNLKPISYEIYFASVFNEFEKLLHAIQKGNMDDFFDLYYEYWLHNNSDVTVQVSKDESEKMHIVGIDDFGFLKVRNCEGEISTIHPDGNSFDMLQGLISRKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPU5</accession>
    <name>A0ABM5JPU5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499960.1">
        <property type="nucleotide sequence ID" value="XM_050644003.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644003.1">
        <property type="protein sequence ID" value="XP_050499960.1"/>
        <property type="gene ID" value="LOC126880211"/>
    </dbReference>
    <dbReference type="GeneID" id="126880211"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="146" mass="17114" checksum="6BB9390CDF5C6A3B" modified="2025-10-08" version="1">MECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQI1</accession>
    <name>A0ABM5JQI1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Photoreceptor-specific nuclear receptor-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500195.1">
        <property type="nucleotide sequence ID" value="XM_050644238.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644238.1">
        <property type="protein sequence ID" value="XP_050500195.1"/>
        <property type="gene ID" value="LOC126880400"/>
    </dbReference>
    <dbReference type="GeneID" id="126880400"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06970">
        <property type="entry name" value="NR_DBD_PNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06950">
        <property type="entry name" value="NR_LBD_Tlx_PNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="251"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52209" checksum="CF0E3B589EC77545" modified="2025-10-08" version="1">MDCSVSQPQPLPMLNSLHQPCSPEQHPCHPNDLRTSPNSADCYSSEGDHPLALCLPSSQTLIQASRTPPPPWNIPTKKGTPGLICVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCVVDKAHRNQCQACRLKKCLAMGMNKDAVQNERQPRNTATIRPETLRDMSAEQERALREAAVAVGVFGPPVSLTMAFSPARYTNSFLPSVAHTTLPNRELTPKDMNNSSDNDEESIDVTNEEDETPTSVCGVSSSSGPLRPEPQPASLASGLYPSTHETIYETSARLLFMAVKWAKNLPSFASLPFRDQVILLEETWSELFLLNAIQWCMPLDISASPLFNVNEHTKNGHSATDVKILGDTLLRFKAVHVDPAEFACLKAIVLFRAETRGLKDPSQIENLQDQAQVMLWQHCRTQLPGQVARFGRLLLMLPLLRIVPALRIEALFFQKTIGNTPMEKVLCDMYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS57</accession>
    <name>A0ABM5JS57_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500765.1">
        <property type="nucleotide sequence ID" value="XM_050644808.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644808.1">
        <property type="protein sequence ID" value="XP_050500765.1"/>
        <property type="gene ID" value="LOC126880757"/>
    </dbReference>
    <dbReference type="GeneID" id="126880757"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="302" mass="35807" checksum="E4F4A0BA9A1AFCC0" modified="2025-10-08" version="1">MNNEENKTEGKRHKPEHDSSIEEDKEEQHKSKKAPDTRIKKVSTILTDMEEIKILLSQMRQEIKEDILESKTEIKDEIKDMKNELEDIKQKFKQNKAETENLKREVEKKEQKWEKENEELKKALTLMENRLEKIDKEKIRNKLIITGIQVDLEDEVRLRENIQKMMETELQLKIEVKSAFKIGYKKCIIETKSWEDKQKILQEKGKLKYTRDCREIYIDAALTFKEAKIQKEIRDIAKQQRSKGAKVAIKYRLSVAAEETRRAECNVLLSTAVNVSTATLERSLSLDAKTWKQRQKPTSWMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSH5</accession>
    <name>A0ABM5JSH5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500889.1">
        <property type="nucleotide sequence ID" value="XM_050644932.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644932.1">
        <property type="protein sequence ID" value="XP_050500889.1"/>
        <property type="gene ID" value="LOC126880863"/>
    </dbReference>
    <dbReference type="GeneID" id="126880863"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045470810" description="Peptidase metallopeptidase domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="12">
        <location>
            <begin position="88"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="447"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="515" mass="58741" checksum="CD0E8F5ECBF393A6" modified="2025-10-08" version="1">MHINKVVLLIATSISFCLGGNFTETNAVSWLEQYGYITTSETANTDITDTLEQFQERYNLPVDGKLNKETMELMQKPRCTQGDNAYAVKSAWKKFDIKWYFPQAIPEALTVTKRVFEIWEEASKFKFTYLRIPNPKPDITITVVPKQHYFRYNCQGNDECPFKFTNGVLAHSYFPPTSGCIEIHMNSNLTWDFSLNSTVEGRTNFFAVLLHEVGHALGLAHSSDKKAVMYPFYETFPSHITDDDKRGLEKLYGPKSKSASIPTKAGVTRSSVPTLNTTTTERSSSTTTTAARTNKSKQNIITNVCELEYPDLIFLAYAPSFPTYRMYIVSKDLVWKYDLNNEKIPTNAEQFIRYFPRGITNVTHVFQSTNGDLIGVSRNRIYAAAFPSLRIHTDNMVPEVNNARSINGLFQTNSGKKFVCFDGSFIEFNDKDIISRGRISDVFPGIPNDITSAFNYIDGHIYFLKQNIYYKFNEFTRSVVEKGTFNWNMLGFPCPDNGLIKQLKSLLSKVNIFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSW9</accession>
    <name>A0ABM5JSW9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501025.1">
        <property type="nucleotide sequence ID" value="XM_050645068.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645068.1">
        <property type="protein sequence ID" value="XP_050501025.1"/>
        <property type="gene ID" value="LOC126880986"/>
    </dbReference>
    <dbReference type="GeneID" id="126880986"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="251" mass="28753" checksum="FD5FA0EDC11F8A0E" modified="2025-10-08" version="1">MRKVLCTKDQVRAKIKVGFWSMCTLTCWCWGIYPLLEEEIRLPLAGWFPFDLSNKINFAIAYIFLIIGAWFNGICNIAVDTLLSALIMVVAAELTILNDSLENIRNFSEAELGVTFKNFGDKGEVSPDLQKIMNQKLIDCIVQHRNILRFNYEYQNVFSNVVLAQFVGSVVLICITMFEMALSTKLTYSAYHCSWENSSEEFKKNLLYFMTRSQVDIKILAGSIFTLNLSCFVTIIKSSWSYFAVLRSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT20</accession>
    <name>A0ABM5JT20_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501086.1">
        <property type="nucleotide sequence ID" value="XM_050645129.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645129.1">
        <property type="protein sequence ID" value="XP_050501086.1"/>
        <property type="gene ID" value="LOC126881090"/>
    </dbReference>
    <dbReference type="GeneID" id="126881090"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="159" mass="18883" checksum="C583EF650DE9F95B" modified="2025-10-08" version="1">MDAETGEFYLDLETGEISEAPTVQNVETGEYEYTRTFKIPSYYYRRYQERKEKTNCTPRKADPLESQLITAAIFLLPTMIFFHPIMLVFVCVIEIFLHTRIHRKNKELEDLSFYYQSPLHGLTKEVCARCKDEKAKNKIAKLQDKQHEKFKNYIKRVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTH6</accession>
    <name>A0ABM5JTH6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501244.1">
        <property type="nucleotide sequence ID" value="XM_050645287.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645287.1">
        <property type="protein sequence ID" value="XP_050501244.1"/>
        <property type="gene ID" value="LOC114328163"/>
    </dbReference>
    <dbReference type="GeneID" id="114328163"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18495">
        <property type="entry name" value="BACK_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="482" mass="55421" checksum="1D0029AE80B74B2A" modified="2025-10-08" version="1">MGLNFSTHKFVSNVTGYVTGRKRKLCDSEDEEINKVIDIALHTPKRKKLESTAQYIYQALFLEGQSSDVTLCALGEEFHLHKVYLYQSPYFASMFGGSWLETNQKYVTIDIVDPSITVDSMKVVLGSLYNCDIILNPLEIVPILATATMLQLDGLIEKCTEVMLETINPKTALSYYTAACQYGDKKLQDVCFKWFLVNLMTYYLHSSRPLSELKTLPISLMAKLIAHPDLFVIQTEYSIYVMLKYWMYYQIFPESDEPSINTINEYFCSLTETLPYLLTAEGKQFISVFLGLRLQNLIAHQHDVILILRDNIIPRTWLDSVILQEWKNVLRINQNDDKGPSDISDEVFLATSLRCGRVLTAKERHVWRWTGFHFGVDLLMITDDSTISIKRNHRSEFGQLLSLQTTRHVAIRVTVTCLNEQRQIVYSKQSDVLKVSLTKGEEIQIMSFDRNTTYPMVISANILYTSPEAQDPPVEERPQYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JW18</accession>
    <name>A0ABM5JW18_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502134.1">
        <property type="nucleotide sequence ID" value="XM_050646177.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646177.1">
        <property type="protein sequence ID" value="XP_050502134.1"/>
        <property type="gene ID" value="LOC126881724"/>
    </dbReference>
    <dbReference type="GeneID" id="126881724"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="311" mass="35332" checksum="9FDA95CC234D9EC5" modified="2025-10-08" version="1">MARHFETVHSEESEVKKCLLHPKGSQKRKQAFLELIRVGDFYHNCNVLSTKKGQLIVIRRPTADEAQFVSDINYGPCPNCLGFLLKKHIWHHVKYTCKEKVNIDDQKESRHVIAESNALVADIFGIGFTKNFTNSIIAKFKNDEIGNTCNNDILILKYGAMQYEKYGDTQNELIRQTMRQLARLVISLKKLTNSRSQTLGDFLVPEKFDVVVQATKDISMTMAASSNCRPEFHTPSLALKLGYALKKCVAIQRGSALRAGNMKKKQVIVIIPSADGNGMEHTNIFQCYIHTLPKKIEFHSTFANYDRFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JW75</accession>
    <name>A0ABM5JW75_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502187.1">
        <property type="nucleotide sequence ID" value="XM_050646230.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646230.1">
        <property type="protein sequence ID" value="XP_050502187.1"/>
        <property type="gene ID" value="LOC126881756"/>
    </dbReference>
    <dbReference type="GeneID" id="126881756"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="77864" checksum="6B677331C44EDC16" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQPTVATAKVRLPEITMQTFCGSFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFSTHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQNSQGASRVVAPISTQHSFNNRSQNEASTSSSRPPLDMQNSPDSQAATSLSALSVKTDVLLATALLQISTISENTSLSNEMLNLEFFPYNVNDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKVDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFVQSEPEENQLDKLLQQFFEIEEVPLVSKLTPDEELAEQIFSKTTLVLPSGRFQDERSVYNQMNDNLVEVNLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWZ1</accession>
    <name>A0ABM5JWZ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD finger protein 14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502456.1">
        <property type="nucleotide sequence ID" value="XM_050646499.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646499.1">
        <property type="protein sequence ID" value="XP_050502456.1"/>
        <property type="gene ID" value="LOC126881859"/>
    </dbReference>
    <dbReference type="GeneID" id="126881859"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15674">
        <property type="entry name" value="ePHD_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15561">
        <property type="entry name" value="PHD1_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15562">
        <property type="entry name" value="PHD2_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15563">
        <property type="entry name" value="PHD3_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF150">
        <property type="entry name" value="PHD FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="572"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="852"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="101802" checksum="A738BA00AB5BA740" modified="2025-10-08" version="1">MTSERTSKARPRNQRRGSTRKPVERDPNKRKVKPVDPGDQTCVLDFDEESSDDSDFRIEDHPEVSDDDDDSLDSQGEGNGAEVSEDNEDESEDSDLEMLKDVGQPKTNGMERSVADVIEQAAKSKLKFNEKDAQIMICCGCLGDQSDGVNEIVECDGCGVTVHEACYGVSDSNSVSSTDSLSPTTPWFCESCKAGITEPVCELCPNSGGIFKETDVGKWVHLVCALYVPGVAFGEVDKLTSVTLFEMPYNKWGTKTCSLCEDDRFARTGVCIGCDAGMCRTYFHVTCAQKEGFLSEAHSEEVDQADPFYAHCKLHSDKTLVKRRKRNYMALQLRTQYRKYQFEQEGHKDSPEQIRIKRKLEKQTVHYLGHKGLKPPPWVPTQKMPRLLTTSASACRKLLRKADLMGINTVVLEMQESQTVALADIRKKWHIPPAFTVEFIAYFLDRNDRLKDMKASVDKYAEENKDLLKEQQELRTKYDKVLKKSNDLIAKSNDLKQSIHKFHSAILSACPTKNLPSIDDLGKPVSNRTPQPMMVPTAAALKMGVGFPLQNIPSGRTDRVLSSHANKDPLQLNECGTCRQRRDQHLLAKCDTCHLYYHLDCLNPPLSRLPKKSKLYGWQCSECDKTSDSEVEELKTPRRSRSIYSNRESKSDQDISTPKLKIKSVDSSADSAEKEKSKSRDSSPSKKKTYENIFTELAQMNGVQVIVDNGYEGYEGSHKSAKKRRREKHRSKSSGSPDASREHKRKKKKKESQEVEEPLPHPRITIKIKPIPLPAGEVASESNPQCFYVPNEADDNAPPPVHPVKAPKVEKREVRKIRSPRVSDASRSPEKSPEKMKSPVASPQKKTAALGGNLCDVCRGEGAPSNSVKCDECQKNYHFACLDPPLKKTPKIRGYSWHCADCDPTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXJ7</accession>
    <name>A0ABM5JXJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502659.1">
        <property type="nucleotide sequence ID" value="XM_050646702.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646702.1">
        <property type="protein sequence ID" value="XP_050502659.1"/>
        <property type="gene ID" value="LOC126881958"/>
    </dbReference>
    <dbReference type="GeneID" id="126881958"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="108"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="310" mass="35823" checksum="D2BCBB880B7E4405" modified="2025-10-08" version="1">MSERKVLNKYYPPDFDPSKIPRMKLPKNRQYTVRLMAPFNMRCATCGEYIYKGKKFNARKEDVENQDYLGIRIYRFYIKCTRCLQEISFKTDPKNTDYEIEAGATRNFMALKLAEEQALREEEEAKEEEANNPMKLLENRTQQSKNEIELLESLEELKDLNKRQQVVDYDTMLSAYDTTISEKEREERMQQLDEEYIKSVKFSSNSKRKLVVEEEIIEEDQPIVKSTKSSDETVNSISNQIPSSSWAKSEVNVKPAPKKKTLIGLVKTNKVNQSSQEADKNKNDNPPQQSTAGGLSLLCAYSDSEGSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXZ0</accession>
    <name>A0ABM5JXZ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502805.1">
        <property type="nucleotide sequence ID" value="XM_050646848.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646848.1">
        <property type="protein sequence ID" value="XP_050502805.1"/>
        <property type="gene ID" value="LOC114327439"/>
    </dbReference>
    <dbReference type="GeneID" id="114327439"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF95">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="31"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="270" mass="30225" checksum="BBED6DF59A86F979" modified="2025-10-08" version="1">MTSERTSKARPRNQRRGSTRKPGSPLSSYGIFGGQDAVEGQFPYQVSLQIDAWPFGYQHYCGASIISPNWIVTAGHCCYTVYPSLHVVAGILKVHDQNEYTQVRLVKERYIHENYTYGVQPNDICVIKVNESWVFNDHVKPIALPIQDFNGTGKVISSGWGQSAGNLFPQFPDVLQWQESEMPDEETCLELCTKAEKLNPYNTTSNVCTANPEKNHGTCDGDSGGPLVLDQQLVGLASWVFLPCGRENAPSIFTRVSHFVDWIKKHDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZM3</accession>
    <name>A0ABM5JZM3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503387.1">
        <property type="nucleotide sequence ID" value="XM_050647430.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647430.1">
        <property type="protein sequence ID" value="XP_050503387.1"/>
        <property type="gene ID" value="LOC114344897"/>
    </dbReference>
    <dbReference type="GeneID" id="114344897"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF132">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="197" mass="21649" checksum="91AB45BA801E9CB4" modified="2025-10-08" version="1">MDDINFAAQCLLEMSHSKDYLNINRPLDLSTHVIREVVFVNAPGPAVIVEKIPPIPSNYVKEETTTTNTESSSYMVARILTDLTRIKQEPVPEVPSDSEGSLTIDEDSDKEKKSPASETPKEKAATPPPVQKAEGVPPTKKANVTRAQTGTRLGSQVRKTHKCSYDGCQKVYGKSSHLKAHLRTHTGKITIPIVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0G2</accession>
    <name>A0ABM5K0G2_DIAVI</name>
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        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503677.1">
        <property type="nucleotide sequence ID" value="XM_050647720.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647720.1">
        <property type="protein sequence ID" value="XP_050503677.1"/>
        <property type="gene ID" value="LOC126882732"/>
    </dbReference>
    <dbReference type="GeneID" id="126882732"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="235" mass="27501" checksum="4D1CA3D1B8807D51" modified="2025-10-08" version="1">MRLHTEDTPYKCEVCSKLFTTKGSVNKHMRLHTGETPYECEICTKQFTFKGNLNQHMRLHSDETNYKCEICSKFFTTNGSLKMHVRLHTGETPYKCEICSKQFTLKGNLKQHMRLHSDKTPFKCEICSKFFTKNSSLKMHKRLHTGETPYKCEICSKQFTVKGNLEQHMRLHSDKTPFKCEICSKFFTTNSSLKMHKRLHTGETPYKCEICNQQFTQISNLNTHIRVHSKTAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0W9</accession>
    <name>A0ABM5K0W9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050503838.1">
        <property type="nucleotide sequence ID" value="XM_050647881.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647881.1">
        <property type="protein sequence ID" value="XP_050503838.1"/>
        <property type="gene ID" value="LOC114328961"/>
    </dbReference>
    <dbReference type="GeneID" id="114328961"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF4">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="368"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="618"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="710" mass="79971" checksum="23B0EC6D0DAABEF1" modified="2025-10-08" version="1">MEEITTTPPKKERIFPRLDLSDQSTLTAAEQPVLIVQSPKTPTLSKKLKAVSLDSDPPAQSTSLEVSRDVFSMPNTPKRQIKQKLSCDFEDGPHKSMLAPSLNSNLKKFASNTSISGSQTLKTLPEVMTLHDFSDGPVTIPVKIKAKGLLERRGSNASLTIDLGSNPSIADVKPVAFNRLNTAKSVSNLNLSTFDSEKCCNCSKKCEAHVVKSVIERRKSQETCGNCTIYEAVPSIMNSCKIVKCQQPKRCSCCPKTRRKSLSNENLYIPPCGFCQTGALKECTGASKHCKGYRKAYYPRQPDLETTQLLSEDFKLHLENIRYLETAGNVLTIEELKKACEVSRVPKLHQEFWEVPLNLQEKCYVSGSQSRNRYKGVLPNEHSRVHLPGPQTYIHANYIKGPDYTETLYIATQGPMAHTCQDFWEMVWNTHCKCLVMLTGLVEKGYNKCELYFPLGKPDDSPEKSFYYVKTTKVRDKFTFDSNVNTQLYEEETQAFEQVNEVTFGNYRITYLNENSIGECHIRQLRLQKLDSAAEPRKISHYWFSNWPDHKMACPEQVLKIALDVLNAMHSKKKSTDNNVNDISKKFDESLSKSTNCNIDLKAKSFPDNFDCSISKKDKMLALSKGTPEARRKSMENLKLPVIVHCSAGIGRTGCFIAILNGIQQLKANSNVDILAILCSLRLNRGGMVQTAEQYELIHRVLSLYTENMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4D3</accession>
    <name>A0ABM5K4D3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501848.1">
        <property type="nucleotide sequence ID" value="XM_050645891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505045.1">
        <property type="nucleotide sequence ID" value="XM_050649088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505046.1">
        <property type="nucleotide sequence ID" value="XM_050649089.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645891.1">
        <property type="protein sequence ID" value="XP_050501848.1"/>
        <property type="gene ID" value="LOC126881568"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649088.1">
        <property type="protein sequence ID" value="XP_050505045.1"/>
        <property type="gene ID" value="LOC126883495"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649089.1">
        <property type="protein sequence ID" value="XP_050505046.1"/>
        <property type="gene ID" value="LOC126883496"/>
    </dbReference>
    <dbReference type="GeneID" id="126881568"/>
    <dbReference type="GeneID" id="126883495"/>
    <dbReference type="GeneID" id="126883496"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="487" mass="55119" checksum="9F8604BC1A408618" modified="2025-10-08" version="1">MPRNYKRVTEKASWREEELQGALRAIQNGMSLRKAAIKFSIPKSTLHERLKNGTAPSGPSLGRKPVFSVEAKNALAVQIKKLAKVFYGITPQEVRRCAFGFAQSNNIRVPFNQERKMAGKDWERGFISRHNITLRKPEATSINRITAFSRNEVTIFFNNLSRLMEKYAFSPNKIYNCDETGVTTVQRPPKIYAEKGQKRVGFVTSWERGKTTTAMCAVNATGTYIPPMFIFARQRMASHLQRNGPPGALYTCTKNGWITEDIFLTWLQHFQAFVKASKEDPVLLIMDNHSTHCTLQAYNFCRDNGIAVLTIPPHSSHRLQPLDVSFYFPLKTAFNSECSKYLISHPGEKITPSEIAELFNLAFSRVATPEKAIKGFKETGIFPYNPDVFTDEDFAPAETLQSTVSDALQEPTQAEKLLKTNETTPEKNSSVNETELKNVSFAEIIPLPSCSHENVVKRQNKANKQHSIVFTSTPLKEELEKKEEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4W1</accession>
    <name>A0ABM5K4W1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505225.1">
        <property type="nucleotide sequence ID" value="XM_050649268.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649268.1">
        <property type="protein sequence ID" value="XP_050505225.1"/>
        <property type="gene ID" value="LOC126883615"/>
    </dbReference>
    <dbReference type="GeneID" id="126883615"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26189" checksum="0F376B710D2C6C6A" modified="2025-10-08" version="1">MEVSPNIYSNLPLFDNSDIDIDQNNENLTCNALNGVSKTPKAIAEKKKQNNMEPEHESEIVEKNKTKNKNKKAAKRQRPNECQEDEDSVAEMKKQLKEKDEEIKNLRNQMHQLNEKINGLQNTIINSQEKVIETIDKRFDELKNENQTTDIQINEKKSMTAIPKKKIEDTNNNIANTKNLPITPTTKTNEDFPSLPKKVGKDNSVPSTSKVSSTDDEIVIPKTYCDVSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5A6</accession>
    <name>A0ABM5K5A6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505368.1">
        <property type="nucleotide sequence ID" value="XM_050649411.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649411.1">
        <property type="protein sequence ID" value="XP_050505368.1"/>
        <property type="gene ID" value="LOC126883747"/>
    </dbReference>
    <dbReference type="GeneID" id="126883747"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="385" mass="44862" checksum="CF42A5A117FF02CE" modified="2025-10-08" version="1">MGAAFANKNGTKTRVICEDTPTDECNEVNDHVISKQLTQCTTAVKEVKAIEKPFVCEICTKQFSQRSYLKVHMITHTGEKPFACEICAKQFSRSIHLKYHMSKHSQEKPFKCEICSKQFTQSPSLKVHMKKHTGESQVECEICSKQFSYRFNLKVHMMTHTGEKPFECEICAKRFSQNSHLKDHTSTHSQEKPFKCEICSKQFSTRYYLKLHMKMHTGEIQFECEMCTKEFSQRSHLKDHIMTHTGEKPFACEVCSKQFSRNTNLKHHMLTHSQEKTFKCEICSKQFSYSSSLKVHMKIHTGENRFDCEICNKQFSRCSTLKAHMNIHTVKNQLKCEICSKQFSYSSSLKVHMKIHTGENRFDCEICNKQFSCYSTLKAHMNLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6H0</accession>
    <name>A0ABM5K6H0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505786.1">
        <property type="nucleotide sequence ID" value="XM_050649829.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649829.1">
        <property type="protein sequence ID" value="XP_050505786.1"/>
        <property type="gene ID" value="LOC126884041"/>
    </dbReference>
    <dbReference type="GeneID" id="126884041"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="471" mass="53061" checksum="869C8BE2CC39B4FA" modified="2025-10-08" version="1">MCAFKVEHLLVDELDYELKIRDVVPEESATVDRKRNLLRGALKQEEGNRSFTQLSAVHIPFEDQRKGISETLDSLSKKIEKFRGTVQDSEYVRLISRLAHISGRVHLLQCTTEEQEPFKKSVSLKNLTLEGELDSKVNPIATSTPNAPVSVVPSFTYSKPVQVHKWGVSFSGEKQHNDVITFLEKVECLRVSRGVSEENLFAASAELFTGPAFTWFMNNRGNLSCWSDLVRKLKSDFLPYSYQDDLLDEIKNRKQKPGESVTMFINTILGMCSRLDTPLSDLSKIKIILKCLLPFYHQQLALMDIQSIDDLTVKCKRLEETLSWSSQPPSTSRPSSNSSSQPTSFRQRSWQNKGPERNVSVFSSVVCWNCHQSNHKFNDCGIPQTRIFCHGCGRENTLKRNCVKCSGNEMSEVRPLSVSPSNTQSGNQTSSENETAGPSTPSNSNPSSNRKGKKASFRKQAHTTNQNQSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7D9</accession>
    <name>A0ABM5K7D9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506100.1">
        <property type="nucleotide sequence ID" value="XM_050650143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650143.1">
        <property type="protein sequence ID" value="XP_050506100.1"/>
        <property type="gene ID" value="LOC126884233"/>
    </dbReference>
    <dbReference type="GeneID" id="126884233"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="635" mass="71907" checksum="67584CA1CE7E6C5F" modified="2025-10-08" version="1">MPKKSAVWLHFDKSADGKSAKCKHCGKLIKSSGNTSNLRGHVESMHKKYVIETSKPGSEEPQPSEPSKKQKLDNNFSVSSQADAGHAGPSTSTQMEFVNPSSAIQIMRQPSIVNTIRRIESYKDGGRQNEKITQSILYMICKDMVPFRVVERVGFKKLMKDALPHYVLPSRFTLKRQVKSKYDVVSSSMRTWLSNKKVTLTTDVWTDLQMRSFSSLTVHFVDEENQLFSGTVGMIPLEDRHTSEYLCEQLRSLCSEWEIQEQNIVAIVTDNGPNIVKAINLFVGSKRHLPCYAHTLNLVCQNSLQNCPELVELLDKVKKIVSWFKQSVVASDELRSASPNKKVIQSVPTRWNSTFNMIERFLELRPIINEIINRHSSAPIMVTAAEVEILSEMCNILEPLYTATNEISGETYLTSSLCIPITSITRKRLEAVTVDKKLTQKLKGEVLKEFDRRFGSIEQFTLLGLATLLDPRFKKMYFKNALACSKYINMVNARLRSLENESDEPTISDTNETDSTVERSRSIFSDHNKQIQAKWKETNKEGTLQRDLHPELSLYLSAPAAKIEENPITIWVDMKGTYPKLSGVVAEFVPLVGTSVPSERLFSKAGQIITKTRNRLEGKLASNLLFLNSLPEKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7Z1</accession>
    <name>A0ABM5K7Z1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506307.1">
        <property type="nucleotide sequence ID" value="XM_050650350.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650350.1">
        <property type="protein sequence ID" value="XP_050506307.1"/>
        <property type="gene ID" value="LOC126884431"/>
    </dbReference>
    <dbReference type="GeneID" id="126884431"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29182" checksum="DD12785907E28B8E" modified="2025-10-08" version="1">MAKNIDFTKLNKIIVNTGNLLSINDITKKPNQNTSEELVEAINFTLKEFGNNGSLQLQPDQQVVISRPQDNLKISEHELFDLKIGFKVFLNTDDQVLLTEAIEKALSLLKVKAINDVIVTFKQKPSEDKKDDLNTIQSAWKVLEDLIETQQIKQIGIADVEENTFKSLYQWAKVKPSIIQINLATCCVVPPSLQTFCKEHDIKLLTHSDAVDILPAQSIQNIFDKPLLLQWALRFLIHVKCRGVLTTKGYLLKFLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8C2</accession>
    <name>A0ABM5K8C2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506438.1">
        <property type="nucleotide sequence ID" value="XM_050650481.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650481.1">
        <property type="protein sequence ID" value="XP_050506438.1"/>
        <property type="gene ID" value="LOC114341616"/>
    </dbReference>
    <dbReference type="GeneID" id="114341616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="634" mass="68796" checksum="BE34136F208CF5C9" modified="2025-10-08" version="1">MSQQPLLNGPTAEFNTSKDEVKEMPKAQQNGNGSQPFQLPGGTPINVQRPLNRNDSKSNFPYRPPFPNQPGGNPPRPPPVRPPGPQQFIPPRSPLPPGQRPPGTPQHPPGQGPPPGQPFPANQPRANFRPFSPFPRPGVPNQRPPGVFQQRSVPSFGNVRPSVPEEGIVRSQTLDTTEIDHSKNDEPKSNTSHDYVKTPSIAAMNNRSYSLSSNAPEIALDSKEDARRKSVSSVDSYGEGRPPSRPSSRQGFGSNENLETKEESSSRPESRPMSRMNKIVEDEDRSPSSLTDVSQKSNDLTPNDNSKSKSPQPVISKTPDLTASRPPSGANLTNGTKTMNDKHLHLNTTSTRPKSSTKEGDNDSGVDESTQGNDQSSNGDNRSPRKSSKSRTSTSTPVARSLSRGSKSPSLKSPDSNVTTPGSATEKKKLPMNKVQVGHAPSPNLKVVKSKIGSLGNTNYKPGGGNVKIENKKLEFKVAPRIEAKNDRYTPKGGEKKIVSQKLQWNAKSKIGSLENTTHKPKGGDKKIESMKLDFKEKAKSKVGSKDNIKHQPGGGDIKIENKKIELKVQSKIGSLDNVKHRPGGGDKKIFDDKEYLRQTSGGSMDQSLSASQNSIPSQPDKVPIADENLNQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCE3</accession>
    <name>A0ABM5KCE3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507858.1">
        <property type="nucleotide sequence ID" value="XM_050651901.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651901.1">
        <property type="protein sequence ID" value="XP_050507858.1"/>
        <property type="gene ID" value="LOC126885344"/>
    </dbReference>
    <dbReference type="GeneID" id="126885344"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24687" checksum="9DCBE65857DE60F9" modified="2025-10-08" version="1">MAENQAGSHVLANMATVSAPSEFNFSLPGSWNQWKKRLQRYMSVSGFINKPEAEKIDMLVYLMGAEAEEIITQFNLTPAQQVYSIIIEKFDAHFIPQKNVIFERFKFNTRSQQPGESVDAYITALHSLAEHCSYGALKDELIRDRIVVGVLDVKVSERLQLQKNLTLGEAVLTVRQAELQNSQNRILRQERVQEVATVNAHRGNYWSQSQAEPNKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCU5</accession>
    <name>A0ABM5KCU5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508011.1">
        <property type="nucleotide sequence ID" value="XM_050652054.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652054.1">
        <property type="protein sequence ID" value="XP_050508011.1"/>
        <property type="gene ID" value="LOC126885480"/>
    </dbReference>
    <dbReference type="GeneID" id="126885480"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33657" checksum="3EDA0DA3310A197B" modified="2025-10-08" version="1">MAENQAGSHMLANMATVSAPSEFNFSLPGSWNQWKKRLQRYMSVSGFINKPGAEKIDMLVYIMGAEAEEIITQFNLTPAQQVYSIIIEKFDAHFIPQKNVIFERFKFNTRSQQPGESVEAYITALHSLAEHCSYGALKDELIRDRIVVGVLDVKVSERLQLQKNLTLGEAVLIVRQAELQNSQNKILRQERVQEVATVNAHRGNYWSQSQAEPNKYGQQNTQGKSNKNYKCTYCSVPSCNSRERCPAKDSCCRLCGKKGHWQARCRSGRNVRVVEGQNCAESEVGIENEMENLQVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCV8</accession>
    <name>A0ABM5KCV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508026.1">
        <property type="nucleotide sequence ID" value="XM_050652069.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652069.1">
        <property type="protein sequence ID" value="XP_050508026.1"/>
        <property type="gene ID" value="LOC126885492"/>
    </dbReference>
    <dbReference type="GeneID" id="126885492"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="288" mass="32498" checksum="198E72367BE9C613" modified="2025-10-08" version="1">MSIRIPTRNGPSQGSDTDLKVIFWNAGGLSNSKFLELKRSVLEKKVDIYVIVEAGAATDTYHLYSTVGYSTHVLKRSRQVASGIIIGTKTPLVCKTNIIHEMQDRDKLEMFQVEVWKNSKHVTLFLLYNPPDNIPALELVEPQIQPSTIIIGDFNSPSTRWGYSRTTNVGKHLEDFLYNNYLDVLNTSPTFLSFRGSQTRPDLVVTYPHITGKTSVTLLDNAAGCGHRALLVTCKLAKDKKAQNRAPRWNFKKADWKKYRECTNKVLTELTLQEPEEAAKKVSEAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD45</accession>
    <name>A0ABM5KD45_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508109.1">
        <property type="nucleotide sequence ID" value="XM_050652152.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652152.1">
        <property type="protein sequence ID" value="XP_050508109.1"/>
        <property type="gene ID" value="LOC114324767"/>
    </dbReference>
    <dbReference type="GeneID" id="114324767"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="122" mass="14247" checksum="B5BDAC8D8BEC76CD" modified="2025-10-08" version="1">MTLAPYIFPTETVILPDTNTTVNQRSLPVSYWFPFDEEKYFNIAFGWEIFSLTLSGHMSFAMDLFFFSTLAYILGQLRILRFMLDNFEKYRAKAEAQTMSTGSTADIVTLKLFIAEHQRMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD76</accession>
    <name>A0ABM5KD76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine protease nudel</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508142.1">
        <property type="nucleotide sequence ID" value="XM_050652185.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652185.1">
        <property type="protein sequence ID" value="XP_050508142.1"/>
        <property type="gene ID" value="LOC114327164"/>
    </dbReference>
    <dbReference type="GeneID" id="114327164"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015420">
        <property type="entry name" value="Peptidase_S1A_nudel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF18">
        <property type="entry name" value="OVOCHYMASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09342">
        <property type="entry name" value="DUF1986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="798"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1651"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1658"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1870" mass="211069" checksum="DDDE911173BD6E2F" modified="2025-10-08" version="1">MDVQGIHEIETINYSPLQRKAALKIEEIKNCILTKPLNLCCLLFEKENTRFSKFCSDHKMLSSFSDVNLRGRRDLPKRSKSVVSTKQHIKYQPVRYIRPLDPYYYYYDSNFDQIEGPFEEYVYYQDYPPDWYYPTYKYYPKESGQRDRDNNHAASTYVNHVKKVLEPNDNFEKSSRNDNQNLKTFHSSVLTDNTKSGDENRKSSFLEELISPTDSKKSMKEDAIQTKGKIKNSKDINKKKLNENLQNYNNNLDNGHTEVDNPAADLNEAAINKDKFQTDDSKFIKLTDVNVKNNEDKPDKMDIPIKVTDDEDDNKGIQKSAEEFFEDRQVAMGRINNGAEIIQRFSSNSDNTKDTKDTNHDPRNRDKGEIPIATIEMQSNGQTMFNPCYNQVSQVPTSYKLVSTDGSTLFKIVASSTPKFSPYVVNPQVYPYMQSPYMIPQQVIPMNQQMQNAPLHVNGPAGQFYVCNPIAAQSSNGVNANNIVNMPGVEVRREATNLQDLLGSLPIPERPRNNGRASQVVCPVGYEACSDDSKCVPKHQFCDNEAHCSDGSDEMFCSCKERVGKLRTCDGYFDCPNGEDEFVCFGCNKDEFSCDDWSKFRKSTCIPIEQRCDGITQCEITGKDEEDCTVLTDNIGQQPLNKISNSIGFLHRNFKGKWFPTCFGPEIWAMEVCKVEAGPVSIFPKTHMVVTTNSYNGDFINVLPNNEVSLVKNCVQDRAAFVECPALFCGMRMNIKNPYRPHEVDISAENMLNDLERIANKHHGQHFDAKMFRLHSLHQKESDQKNEDQGPILGDSRVVGGDPSQPAAWPWLVSIYRNGVFHCGGVLIHESWIVTAAHCTDRYWQFYFEIQAGTLRRFSFAPMEQHRWAAIVISNEKYDRGTLKNDIALMKMSAPVRFNRYVRPLCLPSELTAGRDFTSGPAPGTICTTVGWGATIEHGADPDHVREVQVPILDICKHLDDRGGDEICAGLSEGGKDACQGDSGGPLMCRNPNNPNQWYLAGIVSHGEGCARPDEPGVYTKVGKYVGWIAENMVEDKFIPRFPLQHCPGYTCRSSNKCLPKKHHCDKIVDCLFGDDETECVVSFHNLFSNARNSEDNSVHTIEEELLADIIQESDNSTETAADIQDNGGSNNTNTNHQDQKNNTIVNETYFACESLLQLIPFQKKCNKIVDCEDGSDESHCKCVDYVRSHNPKAVCDGITDCHDLSDEQCVICLETEYYCRLSQKCINITQRCDGKADCSKGEDEWDCVALTNGKTISCDSDSRPELSMSGIISINHNGIWKPYCLNTTNKEPTIASNVCNILGFEEYTTYNNISVQNVPLSEIAIKASSNVEKLPRIDKVENDTQPLNKSSDDIRNKTCGGLFVRCSNVSLDSSVHNVHPDNVSDEVELYTAPWNAVIYCDGIYRCMGAILNSQWIVTSVNCFKGIIELNSHYVAVLLGKGKGTLPVKGPHEQTLRIVESQNIPRTDIVLLRTETRIVYSRYIKHLRLSLRRDGTRKEKCVAIGLHEDKAKYEFLWPIQQCEPGFRCFETKLKTECKDSRAWSGTIVCDSGSGWYPAAVYFEKEGLCGLSSVQKYTSVPYHKREMRVLMDQVSLNSDAPDCDGFRCALGECINKSKTCNGIPDCRGEEDEDWTLCYENEHLCHLTGECECGRTELKCKNKKCIPKSQFCDRKDDCGDFSDEPDVCDCRSYLQLTSPDKLCDGVVHCEDRSDEDPKICPCKSNSFQCVSVNMCVPNDMVCDEIEDCPNGEDEKICKNIVTVHNEPSNAGELVSNTGGLWHPGCFKQNYTKEELVKICDDLAYLGGTANQLNPPKNVHNVTALRPVIESFDMVWIRREKNNRLMLGLRTGNEPYVSFVPDNECFRLFLACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE51</accession>
    <name>A0ABM5KE51_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508438.1">
        <property type="nucleotide sequence ID" value="XM_050652481.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652481.1">
        <property type="protein sequence ID" value="XP_050508438.1"/>
        <property type="gene ID" value="LOC114341448"/>
    </dbReference>
    <dbReference type="GeneID" id="114341448"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027871">
        <property type="entry name" value="DUF4603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611:SF3">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15376">
        <property type="entry name" value="DUF4603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="848" mass="96919" checksum="588C9BF147444A56" modified="2025-10-08" version="1">MKYPQVVSMPSAVSNWLDEQLEARGIDAVVYTRYILSLLHSHTVDVLYPEDDFQFPYSHSKKDVRRYNRGYLGSHRSSSDWWRHVHADAEQIKRSAAIKCLLSASEQNCEIESLVDELCEKLKEVNSETTFPHFNSSEVIAETVYESKKITPQELAEKYYAAFPPLCPQSPSESKLLSLIPKWRNVTASSSPLVTSPIKKKSTRKNLKIGNGNRSHAKESHDTMKARNQTKQRLNCLARNKNNLRNNATFNGWDLSFYPANNKKFANIKRKEDQSDMEESFDQCVEINSNIWDNEDEVNMYEDLPVDIIDLLDSPRPSDDTVEMMNIANMRDTGKRRFIPYGTSIMSSIWSTDQDVTFDNNFNSTIDASQNVANNTEFTLDFKFSAISIDNPSVNSSFDDWPPANSMVENETNALFETNKDFRHKYFSNDFHSLPGNWSVGEGRKVDEEKEIYETEKLLAFSLMKLNHNKEKSGFQEVTPRSASQPKAFNPFGKSVNTFNFKADRDFIENSDKEDLLTSERSHFKPICEKDEVRHQSKYADGATFIISNNLDKVDYKRSESGTMWLETEFGQTKKYYEYKTHGKHVFTDSVELILKFSINENDKACQTDDWESDNEVENYTKVENKMSVNEMPQSSTNNDDHLENPQHHCACPDLTTANATTTALNKDNSSACPTNLIQRPESMLSEVVWKYEEKSCEKCHGNNMAWSNNDWSSSNKGQVDSDWAENGLRSIWSGGEICQNCLVLNGSNLPRPAPNHQLREDISQDGEQLLSDLSTIQKCYMDDLPVVAERSLDILELLSSGVVPKERKRRHSLTVDHNPDTWSFASRIEEDCLMQLAALPALRAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE66</accession>
    <name>A0ABM5KE66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich melanocyte differentiation-associated protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508479.1">
        <property type="nucleotide sequence ID" value="XM_050652522.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652522.1">
        <property type="protein sequence ID" value="XP_050508479.1"/>
        <property type="gene ID" value="LOC126885744"/>
    </dbReference>
    <dbReference type="GeneID" id="126885744"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="33166" checksum="183D2D930190757E" modified="2025-10-08" version="1">MFYKQKSFFCCQHNNDEHPDVRVVELKHLREQYYENEIDVGLDMTSIRTLMLLDKTLNQMTLFPQEHNAEDNDQSLQRLSLAHERMHSMPKILLEEVAPTVKILDISHNEFEKLDFLEQFQELTTLICDHNDITSNQNLPFLPKLELLWMNNCKILDLYRWVYRLSSSCPNLKYLSLMGNPGLPFYINGGSNVEQMRYRLFLLSLFPKLVHLDDKPVTEDERKKSRKLYQKDVLELIATKAQQTMPDYMRRMSQRMSQQMAVMLSCVGTSNSETETKNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEJ0</accession>
    <name>A0ABM5KEJ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508578.1">
        <property type="nucleotide sequence ID" value="XM_050652621.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652621.1">
        <property type="protein sequence ID" value="XP_050508578.1"/>
        <property type="gene ID" value="LOC126885852"/>
    </dbReference>
    <dbReference type="GeneID" id="126885852"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="687" mass="80860" checksum="143FBD755EF37180" modified="2025-10-08" version="1">MELSQVSEKSCKIETSNHELDDALLDTMKIEIKEEPLSESAQDAFVYSDLKELPVKNEIEQDEQKFALFEESQVDEKCFLQDENKLQIMEPLTKPSYHKGDYISRCSEGKTLRKNKKVQTGQKCYKCEICFKQFIDKSNLKRHLTVHTGEKPYKCDICFKQFTRTGSLKIHLRLHTGEKSYKCEICFKQFSQAGDLKKHLRVHTGEKPHKCEICFKQFSIEHSLKIHLRVHTGEKPYKCEICFKQFSIEHSLKIHLRVHTGEKPYRCEICFKQFITASNLKVHLRVHTGEKPYKCEICFKQFSRVDDLKKHLIVHTGEKPYKCEVCFKQFSEAGTLKIHLRGHIGEKPYKCEICFKQFTQKGSLKQHLRVHTGENNYKCEICSKQFSAELRLKIHLRVHTGEKPYKCEICFKQFSIEHSLKIHLRVHTGEKPYRCEICFKQFITASNLKVHLRVHTGEKPYKCEICFKQFSRVGDLKKHLRVHTGEKPYKCEVCFKQFSEAGTLKIHLRGHIGEKPYKCEICCKQFSQAGVLKKHLRVHTGEKPHKCEICFKQFSIEHSLKIHLRVHTGEKPYRCEICFKQFITASNLKVHLRLHTGEKPYKCEICFKQFSQAGDLKRHLRVHIGEKPYKCEVCFQQFSQKSNLKRHLRSHIGEKPYKCEICFKQFIRIHSLREHTKVHPGQNLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF66</accession>
    <name>A0ABM5KF66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine-protein phosphatase non-receptor type 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508830.1">
        <property type="nucleotide sequence ID" value="XM_050652873.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652873.1">
        <property type="protein sequence ID" value="XP_050508830.1"/>
        <property type="gene ID" value="LOC114338186"/>
    </dbReference>
    <dbReference type="GeneID" id="114338186"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14543">
        <property type="entry name" value="PTPc-N9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="344"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51901" checksum="ADFCC2ECE3AA276E" modified="2025-10-08" version="1">MGGYPAKLKKVLIVTAPLWFKAPFKILRLFVREKLRERVYTVSVAQLSSHIPRESLPTQLGGSLVLDHNVWLSHCIQSMTSTRPESPISHYDGKTPSPQKRTSAPSDIDISGSGNGVDSWAEEANLNPPSSASSGFSDDDSLHGDGAALTAMQLVDYVRDRGRSGLMQEYAEIRSRPPDGTFNIAKSKSNLPKNRYTDVLCYDHSRVILTELDNDKDSDYIHANFVDGYKQKNAFINTQGPLSKTTPDFWRMIWEQHTLVIVMTTRAMERGRPKCHQYWEPEVGWETTYGQFGVKTESIETDKDYTVTTISLTNNKTEETREVSHWQFTSWPDYGVPHSAKAMLEFLERVRRKQASMVVELGDTWAGHPRGPPIVVHCSAGIGRTGTFCTLDICISRLEDVGTADIRGTVERIRSQRAYSIQMPDQYIFCHLALIEYALMKSHLQTADLTGFDQAVEEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFL2</accession>
    <name>A0ABM5KFL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508991.1">
        <property type="nucleotide sequence ID" value="XM_050653034.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653034.1">
        <property type="protein sequence ID" value="XP_050508991.1"/>
        <property type="gene ID" value="LOC126886180"/>
    </dbReference>
    <dbReference type="GeneID" id="126886180"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="119735" checksum="9A6BEC875B7023A8" modified="2025-10-08" version="1">MIHNRMRFAKTIGEKHHLEAQMRLVKTLRNQLNAEQKKGAGLKTLPETAKRRVQWDDSLSTFNSRIQTGVISNLKHKDPGSFLVDCKALFKRRIQNALKNNSAVKVNIAFGGEFEIAQGDKMINETKYFTTSNSAIYRDTNLDEWFEKKVVEPINRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIELPHLIKRKKACINVKNDDEACFAWAVISALYPCQTNSALMSSYPHYSNILKLKGIQWPMSIKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTRNKKDKHVNMLLIQDKYDDQGPIRYHYVWIKNLSRLLSKQLSKENGTKYFCDGCLHYFRSQDKLNVHKTCCKGRSDVICDMCLQLFSSSTQLEAHINDCEIINETAIKMPEESHKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVGYYFKCSYDDSLSFYKSYRGKDCMKWFADELNQLAEDVSTVFMCSFDINMTFQQESDFQAATHCHICEQRFSPGDKKIRDHNHLIPENNYRFAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVTDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSQYVFLPEEQFNLLTVKGIMPYDYIDSFDRFIETCLPPIESFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLADVFERFRSSCLETYNLDPAHYFTLPGFTWDAMLKYTKQELELLTDPDMHLFVERGIRGGLSQVCSKRRVHANNKYMVSYDPSKPDSYLMYFDVNNQYGWAMSQYLPFGGFEWTDTDIDVLSIPDDSSEGCILEVDLEYPQHLHDRHKDIPFCPQSLNPKTMKPPKRPRELTKLMATLHDKERYVIHYRALKQALAHGLILKKINRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTLECVRRRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLIAVEMHRAEIWLVKPILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI04</accession>
    <name>A0ABM5KI04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trichohyalin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509846.1">
        <property type="nucleotide sequence ID" value="XM_050653889.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653889.1">
        <property type="protein sequence ID" value="XP_050509846.1"/>
        <property type="gene ID" value="LOC126886820"/>
    </dbReference>
    <dbReference type="GeneID" id="126886820"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="85180" checksum="09F88A419231F0AC" modified="2025-10-08" version="1">MLPLKKLICSKSVWILFICLTSTTFGFLENLSRNDISRRNVRGSRSSVESVVEEMPFRKDTRRQVNEKDRLYENLYDRRSFRTGTDRFRNRNIDIRLDRRNQNWNDERRALNDRVFLTPVPDITIPIRGVPNERRSRDVRLNREQRVRSPDNRSERLFRDDRRSRDTRENEVQRERREETFTDNRMRNIRETQPRSLNIRAERMVRETLSRENRQQDQHIRQLRTRNNRQRELRTNDDSRLQNRDQRVERNIRTNQERINERRQLQERREESQDERRQLQERREEPQVRNHREQSRERMLKSRNEYLSPSRYEQNLRNSERRIDNRERNVEIRERRQENQERIREETFRYNRDNTLEKNRQIRSLNGRQERRTAFEATMDARESRNLSTRRFRDTQERNIERRMANSYRDSNERSLERRDVRSVRSSRIRNNRSNGLDANMNEIRQNRERNINIRSEDRSDLYREREERNQRERQFSREHRYMDRSTYARRVGESRYRYDNAYSRSFNMPSRSVRDLPIRASLARSDSARQATEARLNSGIAERETVRDLPQRASLTRSDSTRQAREARLNSGDSRQETSTCTSVQRDINRQISIQRNTRENDARPKEQPRDAVSRSPNSIERRSVPVVEFVPNSRRYGEELKDIPYHKHNMKLDALANVIQVILGVYLIGQILAHSSKKKSYGLYKMLPTLSAIKEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJH1</accession>
    <name>A0ABM5KJH1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510357.1">
        <property type="nucleotide sequence ID" value="XM_050654400.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654400.1">
        <property type="protein sequence ID" value="XP_050510357.1"/>
        <property type="gene ID" value="LOC114325364"/>
    </dbReference>
    <dbReference type="GeneID" id="114325364"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1308" mass="146707" checksum="EC0AA69B73BDA9CA" modified="2025-10-08" version="1">MDQQSTSKPPFSKGVQVASLVVESKPYPLFKGVNTIGRNRTAVVNIKHLTVSQHQAVIVAIDETQMYISDMNSSNSTFIHNSKMIPLQLYKLANNDDIKFGELNAIFSNIVVTDPTQNDAAEASQLSQTQNFYSSDTQVLVNPTDITSTGVNNDQTVSDINIHEMATQVVEFHPPPVPKPKKFHFKKVVQTQVKDQENHVVQIPGNEVAKNEPVQNVIIETVYGIHDLPTQVLNIHDLPTQVQSFVPTCSKEEDNIHEMATQVFNHSIQPDENPIEKLLPDNEKNEETDSTSDSNTQIMTQEEMEAISKKLNDTTVPVSLVTPTDTQELLNSIQESIREHKILKDREDKIFDKLNTKFASKTIHDSQEPSTSGVQNNCNEYDDSFASSIDSTKAEDFAIEETFLDSFQNNDSMDFLIAEAENLESQPTSQLLKSKNSQNELDENISAHKSPERDPEINCKATDKALEQGGQGKDDSSDSDTDCEDALLEDLSLRLSANNSHEATSTDPQMKSTDPQIKSTDPQIKSNKDFDDLDDSDCIPATQDFFAKELDYKPLKSSQTSNVQSSEESFKLGLTELMEFPELDDLDNAKKPKSQEKRSSLDKQGVEDCKNIDSAQKSDTTTINDADPKILDTLDACFEATQENDDVFLASTQLVPLNEPSERKQPTKEDVYSLPTQKLNDDVYLEPTQQIDDVFRQPTQPVSPKKVVDRKKPAEEDIYCQATQKLDDDVYIEPTQQIDDVFLQPTQPVASGKVKDKKEPTKEATQKVDEDVYLEPTQQIDDTFLQPTQLLEPTDRKKPTKDLYSQPTQKLDEDGFVQPFNIRKQPVSKNVTTDSEDVFLIPTQPLDVEDKPEKSKSFTGDESFKSKGNTSLKLDEDPYIQATQPIEELATPNKSRPKIGDTHMSQNDITESQLEMENYGTFEPNSSIRRDRPGNPILCELDNKNSDNKDDSDDDNTCIESMSQIEAYIGGSRVVPPDNIKKETISPKVKGNTSLNISIETLSQIEAFIKKPLPPRMSDRGYQTKKKTEKENEDGPETLSQITSFIAKPQGIKIKEEKRLSHMNSSNNITKSRITGVHNELSFNSTLNERNLLSDVDQSFALLESKSSRVKRKPTLGPVYEDVKVNVTLHRRSMQVEENNDDTFIVPTKKQRTGNDRNTLRISEIELPTKKSQSKRSKVPSPIPETKSDTKSSNKETKTKTSSTKTSSKSSKDNDYLPKDNKVQKDAEEVKNSPEKIRRTTRTTAGKTTKKSSIASGYSKSSKSKESTENKPSTSEDIKSAEKRAPKARGRTKNKETEPTAPKSKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKU7</accession>
    <name>A0ABM5KKU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510773.1">
        <property type="nucleotide sequence ID" value="XM_050654816.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654816.1">
        <property type="protein sequence ID" value="XP_050510773.1"/>
        <property type="gene ID" value="LOC126887358"/>
    </dbReference>
    <dbReference type="GeneID" id="126887358"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="559" mass="65338" checksum="E0DAFBDD51D3FD27" modified="2025-10-08" version="1">MECNENIKDSRNQEVLRAIIDEGDSLQKYDSIEVKSELDESSYGQESVLDEYCSDSDDIKIENNVLENVSNEIKVEIKKELEECSIGDPQDITGKVTKPFGAPKEHLKTYTGERTYKCEICSERYTTKNSLNEHKKIHTGKKPYKCEICSKQFTQKSSLNTHKRVHTGEKPYKCEICSKQLSHTSALIYHMRVHTGEKHECEICSKKFTDINHLNTHKRVHTGEKHYECEICSKKFNYISNLNTHKRVHTGEKPYECEICSKQFANRDHLKGHMRIHTGEKPYKCEICSKKFTQKSSLNTHKRVHTGEKPYKCEICSKQFSEQKTLHSHNRVHTGERPHKCEICSKKFTEKSSLNTHKRVHTGERPYKCEICSKQFANRDHLKGHMRIHTGEKPYKCEICSKKFTQKSSLNTHKRVHTGEKPYKCEICSKQFSEQKTLHSHNRVHTGERPHKCEICSKKFTEKSSLNTHKRVHTGERPYKCEICSKQFSRLSSLNCHMRVHTGEKPYKCEICSKRFTTKGNLKIHMRIHTGERPYKCEICSKQFNQLTRLKDHMRVHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL39</accession>
    <name>A0ABM5KL39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510910.1">
        <property type="nucleotide sequence ID" value="XM_050654953.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654953.1">
        <property type="protein sequence ID" value="XP_050510910.1"/>
        <property type="gene ID" value="LOC114334244"/>
    </dbReference>
    <dbReference type="GeneID" id="114334244"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="83"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="279" mass="32460" checksum="C0400583C991E6C3" modified="2025-10-08" version="1">MGNFRRDLEELKQFRDSNDRKSREVVNIWNSSIHSNVDKLGKEKHVVLEQVCMAALDSFNLKIAEICIKELYEEFPNSCRVQILESMLHEADENFDRALLILKNIIKLDATNSSARKRKIAILKSLGRNSEAIKELTEYLKVFMADIEAWQELSELYLTEFDYNKAAFCVEELILHNPHNHLLHQRYADIKYTQGGLENIEVARTYYYQALKLNPNNMRAMYGIYLTTSALLNTQKAVTGKKKDAVNKLLEWILKEIKQRYVEKQQIDALKEAVSALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMX1</accession>
    <name>A0ABM5KMX1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511529.1">
        <property type="nucleotide sequence ID" value="XM_050655572.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655572.1">
        <property type="protein sequence ID" value="XP_050511529.1"/>
        <property type="gene ID" value="LOC126887767"/>
    </dbReference>
    <dbReference type="GeneID" id="126887767"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF2">
        <property type="entry name" value="AT24727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="557" mass="64220" checksum="951BA1DEBFEBC617" modified="2025-10-08" version="1">MGSDSDNEEKGSCEVCKSAAVRKCSACKLVFYCSEAHQQEHWKEHKIKCRPFEEQNSKELGRYLQSTRELQPGDVIFSELPLVFGPKPHRIQEGPFPCVGCCRLLHDQMCEMCPGCLWPVCRTTCEGLKIPSQHGFECNVLRLKPASDAKAFLDFYRFDILIILRALYLQKANPKKFETLLKLESHFDRRGPGTEVYKAVQEKIEVLEENYLKPLKLYEEETGQVILPQVSAELIHKIYGILDVNATELIEDVDAMILYPTASLLEHNCIPNTTQIIDEHDNFKITFRAAMAISKEEHITSMYTNILWGTAARRDHLLETKYFKCQCKRCQDPSELGTNMSALKCIAGSDQDPCGGLQLPITPTYQNGAWMCNKCKIKLPEMDVMKFVHHLGTEVDKIMTKSPKYHELQDLLSKLLHFLHPHHYLLYNIRHTFIQLFPDRDIVDENSPEIWLEKLNMCEDLIDLTKTIDPGNARLSLYLGVLLNEKFIAQFKLLLTTWNKPNQNLYTNQIKGDILNTLEENKRILMYEQKTNAGHKLIEVVTGNEALFENWRREHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRQ9</accession>
    <name>A0ABM5KRQ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512875.1">
        <property type="nucleotide sequence ID" value="XM_050656918.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656918.1">
        <property type="protein sequence ID" value="XP_050512875.1"/>
        <property type="gene ID" value="LOC126888569"/>
    </dbReference>
    <dbReference type="GeneID" id="126888569"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30232" checksum="D1FE84A162BDD25F" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYIVANLDTAYILEVRDIIVSPPATERYEKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAPRAQISEASNALESTIEKLTVELAEMKIQLSSLSNAQAQANTYRRNRSNSRGRPYPRDRSYSRERNSDICWYHYRFGDQAQKCSPPCKHQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVS7</accession>
    <name>A0ABM5KVS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514290.1">
        <property type="nucleotide sequence ID" value="XM_050658333.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658333.1">
        <property type="protein sequence ID" value="XP_050514290.1"/>
        <property type="gene ID" value="LOC126889760"/>
    </dbReference>
    <dbReference type="GeneID" id="126889760"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175435" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="611" mass="68188" checksum="6173C6737E3A54D4" modified="2025-10-08" version="1">MNHFMKILWLCSLVSSAFTQDLDQLYSYVSAKIAETNSYQTPINNERLFKTNNSTIYDFGQYDFIIVGAGAAGCVLANRLTEISKWNVLLLEAGGETNAFSDIPRYSNALKQTDMNWGYLTTPQKTCCQGMNNNQCIYPRGKVIGGSTTINAAIYARGSASDYNHWAAMGNLGWSYNHILKYFKKSEHVALKSYDINYHGKNGELYVNQTTPPSIVSKYYIDANKEKHLKEIDYNGRRQLGVSRIQFNQKDRVHQNAAHAFLDGIKTRSNLKIVLNAGVNKILLKGKKATGVTFVLNGTIYKATAGKEVILSAGAINSPQLLILSGVGPKTDLENLNIPVRNDLPAVGRNMQDHPLFGNLYFRTNLSSPVLSLKENLANYLEGKAPFTNGNGLENIAFINSDHITTGELDIEFLTFAPPLGVPAKNLQNLQDDVAKVFSEYNTSTDLGVCIALMKPMSKGKVTLQSNNIVDFPLIDINYFSDANNNDLETMYKGIKYILSLADTKAFKSINATFVAKQPRCEHLKDKDREYWYCALRHMAVTEFHPAGTTRMGLSKRNSVVNTNCVVHEYKNFRVVDAGVMPEITRGHLMAAVYMIAERISDEIKKAHRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWD8</accession>
    <name>A0ABM5KWD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 6a14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514503.1">
        <property type="nucleotide sequence ID" value="XM_050658546.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658546.1">
        <property type="protein sequence ID" value="XP_050514503.1"/>
        <property type="gene ID" value="LOC126889862"/>
    </dbReference>
    <dbReference type="GeneID" id="126889862"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="58613" checksum="7ECBEF78AF811370" modified="2025-10-08" version="1">MLLYFVYFLLALPIVAYLYVKWVYGYWQRRGVYTVEPVFPNGSFQDVRKGKISNFDFYKKFYSDVKKKGLKYGGLYQLTQPTWIPVDLELIKTIMSKDFGHFTDHGLYINTKVDPISGGLFMLEGENWRNHRAKLTPTFTSGKMKMMFHILATQSKGFEKLLAQEAAKKEPVFIKELLARFTTDIIGSVAFGIDCHCMIEPDNEFRIQSQKAFGIRQRYKQLMRMYFSNKMLTLFSYKQTDEDVDRFFSNLVRSTIEYREKNGIYRKDFLQMLIELKNTGTVTDDEVMKKSTHGKPFLTIEEVTAHSLTFFLAGFETSSTTMTFALVELAQNQDIQDRLRAEILDVLEKHDGELTYEALKEMEYLEQTILETLRKYPPIPILPRVCTRTYEVDSKLTIKKGTAVQIPVMAVHHDPEIYPDPLIFDPDRFSKENSVGRSNFAFLSFGEGPRLCIGMRFGKVQSKCGLITILKDYRVTLNEKTQTPIKLTPSFITGVQGGLWLNFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY26</accession>
    <name>A0ABM5KY26_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515096.1">
        <property type="nucleotide sequence ID" value="XM_050659139.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659139.1">
        <property type="protein sequence ID" value="XP_050515096.1"/>
        <property type="gene ID" value="LOC126890281"/>
    </dbReference>
    <dbReference type="GeneID" id="126890281"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25716" checksum="78F5823270A71CCB" modified="2025-10-08" version="1">MTYQFYSGSIVSSLLMKPRTLIKSMEDLLNSGLEVGCESTLFDMDYLKFTTDKVTRKLYLTKILGKGNSSNFLRAYDGLLLVKKGGYAFHTETSVAYDIAIKTFSEQIICELKEVRMYKNRPAHLALQKNSPFKDMFDTCLLRLTEYGVFSKQERFWQVQKPECTHSSLALATLGLESFYPLFIMLLIAMVISLVILVIEIYIDFKGRNKRTNNLVPLFQYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0A0</accession>
    <name>A0ABM5L0A0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515866.1">
        <property type="nucleotide sequence ID" value="XM_050659909.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659909.1">
        <property type="protein sequence ID" value="XP_050515866.1"/>
        <property type="gene ID" value="LOC126890736"/>
    </dbReference>
    <dbReference type="GeneID" id="126890736"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="462" mass="53817" checksum="351E40BF7C4C0A5C" modified="2025-10-08" version="1">MEHICTECTLTFSKHSNLRSHLKTFHPDKLDIIAPNKTFKSIVLCNKCPKRFSKYSNLKRHVTKFHPENINELTSSKICPYQCSECQKKFSHLQNLRKHKKIHAKDSNIGKKQQNFKCSLCNYENSIKSNLILHFEEYHAIKIEQQDLHFSSELEFQKWKTDMEKKEFSSYVTYSHPYTTAEGIKKQSYICHRSGFYVKKGKDMRYLKTKGSRKINGICPSRLKVCILPENGNVKINFIQTHIGHDNDLDHLNITKNGKIEIASKIASKIPLVSILDEIRDSVTNNKLERMHILTRKDLHNISQTFNLNSDGIRHKNEVISIESWIEEAKNSGIILYYKPQGALCNDFPCLKNEDFLLIVMHPGQLEVLDKYSEDVICIDGTHGLNAHDFELTTLLILDDMREGFPCCFMIGNRSDEEIMTIFFMKIKENLGRVIKPMVFMSDMAQYYYNAWLQIMTPAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L120</accession>
    <name>A0ABM5L120_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PFC0760c-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516135.1">
        <property type="nucleotide sequence ID" value="XM_050660178.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660178.1">
        <property type="protein sequence ID" value="XP_050516135.1"/>
        <property type="gene ID" value="LOC126890998"/>
    </dbReference>
    <dbReference type="GeneID" id="126890998"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24731" checksum="E163FE3D16AC7D15" modified="2025-10-08" version="1">MQSKQTLNDFPKISVNLKNSALSAVKALHVVANGDKGLPRQTRKNLRNFTNFAWDKESQEYSTKIEDTKNKLSMPDLVAVCSVLDLNYTGSEDDVIEHASDDDGDKDVYHKENGKDFTEDDRYNEDKDANSDKDAYHEEEGKYVTDDDNNDDDMDDERTTDLFTRNRSKSNKMTRGRLNDSFSLTFRDVEDSIRNFDGKDDYPIGNGSLILKKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2I4</accession>
    <name>A0ABM5L2I4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516654.1">
        <property type="nucleotide sequence ID" value="XM_050660697.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660697.1">
        <property type="protein sequence ID" value="XP_050516654.1"/>
        <property type="gene ID" value="LOC126891520"/>
    </dbReference>
    <dbReference type="GeneID" id="126891520"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="305" mass="35150" checksum="132E47381E26F321" modified="2025-10-08" version="1">MSKASTAPYNTRSVKDADGASEDEPKPNQDVSEGQYQPYIPGKLGYNDEIRIPIQDLDAFTYPANSYLYIEGQLVTHDNKVPTKLKFINNAIAYLFREIRFELNGVVIDSVRDVGLVSSIKNYLSLNENQSLQLENSGWFPKRGRLETNNEVPKDSVLVDSNGNFNVCIPLRLLSGFFEDFRKIIMNLKMELILIRSNDNIDAVVSEDESERPKIDINKVYWEVPHVTPSIQEQLRLNKISHTNQELPIQFRSWQMIEYPALNNSTRHTWSVRTSTKIETPRHIIVAFQNNRKSKLTKDMSKFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2X9</accession>
    <name>A0ABM5L2X9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pre-mRNA-splicing factor CWC25 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516801.1">
        <property type="nucleotide sequence ID" value="XM_050660844.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660844.1">
        <property type="protein sequence ID" value="XP_050516801.1"/>
        <property type="gene ID" value="LOC126891624"/>
    </dbReference>
    <dbReference type="GeneID" id="126891624"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="82123" checksum="DBFB5F5A403CA3BE" modified="2025-10-08" version="1">MNNNGDTDKLDWMYKGASSHIDQEEYLLGKSVDKSFEQINKEEKEKKLGVVPPKNHVEHECIPPSIRDYNKIVHEDQVDLSAKLQEDPLMAIKKQEEEARRQFLQNPIQLKKLQDALKVQEDKKKKKKKKKRKDSDSEDDLDQQIAEKLKHLKGNFKDLPKKKKKSKTEHLDTILMHKFNQLKDKLSQEDMDDILAGKSSSSDEETPKKKAKHKSTNSEEDSDDQEKTSKGKTYRNKQDDVKDKQNRYKRNSRSTSRTRSNKIHEKYKGHRKSTSRDRSKDRGRNRKNSSSDSEHERRNKTSKYEKQRDNRYNGSRDRSRERTKRRKSSSSEDRYERSRKTQKYEKPNSRHQLSSRNRSKERERRRRDSSSDSEDGRSSKTNKNNKQRDHGKDSSRDRSKGKEKSGRNSTSESEDERNGKTYKNNKQGDHRDSRDRSRGKEKSRRNSTSESEDERNSKKYRYEKEKSRRSVSREESSEKKRNNGRSNKKHDEKHERNRSTESNSDSSSKEASADNDLDKMILKKLQMLRESAVGNKEDLEDGQQTYSHYDSDNDEYVYKKKSFGLVRSDGTKIPLKNPPTDNKKVPPKKIDAPKLPDTKNKPNKRLTDKEKEELRRQMMVDAVHRDKERSDHLKKHRQDNQKEESKIETFDKNFVHRELYKGQSDLKDVESRLKTKLNNIQRSSQHMNSNFSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4R0</accession>
    <name>A0ABM5L4R0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517426.1">
        <property type="nucleotide sequence ID" value="XM_050661469.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661469.1">
        <property type="protein sequence ID" value="XP_050517426.1"/>
        <property type="gene ID" value="LOC126892043"/>
    </dbReference>
    <dbReference type="GeneID" id="126892043"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046450697" description="Lipase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="4">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="5">
        <location>
            <begin position="133"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="431" mass="49561" checksum="3B5DA0FF32932690" modified="2025-10-08" version="1">MLTRQLIEKLTFNMLLSVFLLCLFYVSTTEALISRTKNVKNVCTDFRAYDAQSMNKSKKCFYNPDLNSAPSEIAIRHGFHLEEHRVTTQDGYILTIFRMKPKIKDIKSSQEPVILQHGIFVDSRSWFISGNSSLAFKLVNDGYDLWMPNFRGTTYSKKHSNKNISQKEYFNYSVHEIGTYDVTAIVEYVANFTERKDIAYIGHSMGTTAFTVYATEKPEHSRKYIKQIIFLAPVINLSHPPVALKIVLPYTYVIKEIFDSLKVYAIGNLSEVQRLFTTAFCRNYPLIVGCQIAMSLVSGIVMEQVRPEVVPLIVKLFPVAISVKSLVHFAQIALNNGTFQQFDYGDQLNMKKYNSTMPPKYDIDKMKIPITIFAGSHDILSEIQDVHRFYDSLKSPKALHTYELSHLDYMYGKDVIDMYNDILQVLKKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5C5</accession>
    <name>A0ABM5L5C5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="12"/>
    <dbReference type="RefSeq" id="XP_050517642.1">
        <property type="nucleotide sequence ID" value="XM_050661685.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661685.1">
        <property type="protein sequence ID" value="XP_050517642.1"/>
        <property type="gene ID" value="LOC114330679"/>
    </dbReference>
    <dbReference type="GeneID" id="114330679"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF29">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045157954" description="Sphingomyelin phosphodiesterase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="14">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="615" mass="71006" checksum="3344414AA439B858" modified="2025-10-08" version="1">MKSWHFVFLSITVLGSSAWNHWGETDPFHRLISHSLFGNTPYFGSSLVARTPDINRAISDEDINPIDFRNLLRDILEIPVMKLFSIHSSCDMCKELVNIIHSRGYRHSKVPKFICQVYYLMANLSFPTFCSHMAKQNLPVLKYVFNNIENVDPELVCTIVLQTENCTYSKPALSWTTRIPRRTLPKYPKHEKDPNKRPLKILHLTGPHVSFDYEENGAVDCGAPLCCKKGLGNKSSGRNAGYWGEYTCDIPPWLYGDTLQQISNTHKDLDLIYFTGGIRDHTLWKSSHYAMTEAIFLAFKSLKATFPDTPLFPVIGNHEPSTQNQFAPNKPDIYSKGLSTKLLYIHFAAFSQWWLPENTLKTIQSQGYYAHSVSDRLKIIGLNNNVCYKFNWWLLLETKFLDEQLQFLVKELEDSEKNEQYVHILTHIPVGNNDCIKPWEASYNIIVQRYAHIIKGQFYGHTGTDGFKIFYDRFRSPINAAFNGANLSPYQNYNPSYKIVHVHPDTMDVVDIETYYFNLTEANLSPDRSPNWKKLYSMKEDYDLPDLSPKSLDGLVDALFTDTELMDNYWKYSVRLADPSLNEKCDKKCLQEMRCNIVTTQSGHPEKRQCKQPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5F8</accession>
    <name>A0ABM5L5F8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517675.1">
        <property type="nucleotide sequence ID" value="XM_050661718.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661718.1">
        <property type="protein sequence ID" value="XP_050517675.1"/>
        <property type="gene ID" value="LOC126892209"/>
    </dbReference>
    <dbReference type="GeneID" id="126892209"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="388"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="486"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="577" mass="67127" checksum="B46E3316121440DE" modified="2025-10-08" version="1">MINSLTQIHENFQLEVSQLNNRIDTLDEKQNSLVNKIQQQQNSLVNLEQQQNDLKSNLERQIVELQTKINTQASLSHISVTNIDSEQTAPSSSIVYPGTVRTSKILKPPTFDGQTAWETYRFQFEAAARANGWNENEMAASLVVSLRGQAATVLQFLPQDAPNYTSLVQALETRYGQQHLKQVFQSQLKVRYQKHNESLQEFEADIKRLLHLAYPQAPRDFLEQIGIQAFIDGLHDIEMQQALRLQHHKTLDKALISAQEYEAAKNISRSLPQLKEIRFTENKQVTTTDNEQLVLSQILSLLQNIQQKPRNENRRCFNCGRMGHLKSNCRSRSQARKEEYKNEIRRSPSSTSRSLSQSLTRNDGRWSLRNRFPTTDHRKEENTLEFEVSHLKEQLAISKNKIERLREQVTILQEECKVIQNNAKTTQSNLENECQKLMKEKNVLNKQVQSQRQLAQKENVTEEVSLRMTTVEQSPKKRDDSNPEMLAQMMELLKELAEDTKEIKNQQKKQAETMNMLTEELKELKEEQKEYRREMGDLKLANEKAIKEINQLQNQLSNTNIRLQKLEGEKRKRNIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L919</accession>
    <name>A0ABM5L919_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Cytochrome c oxidase subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="17">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518936.1">
        <property type="nucleotide sequence ID" value="XM_050662979.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662979.1">
        <property type="protein sequence ID" value="XP_050518936.1"/>
        <property type="gene ID" value="LOC126893038"/>
    </dbReference>
    <dbReference type="GeneID" id="126893038"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13912">
        <property type="entry name" value="CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034210">
        <property type="entry name" value="CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01166">
        <property type="entry name" value="CYCOXIDASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="Cytochrome c oxidase subunit II-like, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0186">Copper</keyword>
    <keyword evidence="11 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II transmembrane region profile" evidence="20">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="19">
        <location>
            <begin position="87"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="216" mass="24866" checksum="F464707F7D196CB2" modified="2025-10-08" version="1">NFILQDRTSPLIEQLSYFHDHALIILVIITVLVGQLYFFLFFNKFLHRNLLEGQLIEIIXTILPTITLIFIAIPSLRLIYILDEVNNPAITIKTIGHQXYXSYEYSDFKNVEFDSYIIPTNELNNFNFRLLDVDNRIVVPFETNIRILVTAADVIHSXTIPSLGVKIDATPGRLNQISFSLRRSGIFFGQCSEICGANHRFIPIVLERISPKYFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FA92</accession>
    <name>A0A6P7FA92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114327319</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131707.1">
        <property type="nucleotide sequence ID" value="XM_028275906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FA92"/>
    <dbReference type="FunCoup" id="A0A6P7FA92">
        <property type="interactions" value="1685"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275906.2">
        <property type="protein sequence ID" value="XP_028131707.1"/>
        <property type="gene ID" value="LOC114327319"/>
    </dbReference>
    <dbReference type="GeneID" id="114327319"/>
    <dbReference type="KEGG" id="dvv:114327319"/>
    <dbReference type="CTD" id="35688"/>
    <dbReference type="InParanoid" id="A0A6P7FA92"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028131707.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14507" checksum="60DADF272ACCB5D5" modified="2020-12-02" version="1">MTTLYSLADVKKHNDNKSTWIVIHNNVYDVTPFLNEHPGGEEVLLEQAGKEASEAFEDVGHSSDARELMVKYKVGEVVEEERTAVKAKNVDWGVSSNNESSSSQNSFKSWLIPIALGVLATILYRAYFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FD57</accession>
    <name>A0A6P7FD57_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114328159</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132742.1">
        <property type="nucleotide sequence ID" value="XM_028276941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FD57"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276941.2">
        <property type="protein sequence ID" value="XP_028132742.1"/>
        <property type="gene ID" value="LOC114328159"/>
    </dbReference>
    <dbReference type="GeneID" id="114328159"/>
    <dbReference type="KEGG" id="dvv:114328159"/>
    <dbReference type="InParanoid" id="A0A6P7FD57"/>
    <dbReference type="OrthoDB" id="206708at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132742.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40385" checksum="F1F125BEC6B017A6" modified="2020-12-02" version="1">MNKEVDIISVIVPIYNGAKWIDPCFHSILKQNVDDTQFQLEVCVCNDSSTDETSTLLGKWKDHFQEAGVSLKVFNNRSENPGGVGFAKNKAVSISSGRFLCFQDIDDVMLPERVQKQYQVAVNSSVDTIVGAQFKREPEDSTVRYTKWANSLSQEQLSIQVYTSHGPTVIMPTWFLYRDHFDEVGGFVEKGMGTPEDLIFFYKHLDLGGKIIRVDECLLIYRFHSNQATFSVHQDTIWNLRVDRLQKKILSDWPQFTIWNAGKQGKKLYNSLSKENQAKVVAFCDVDSNKIGKPYIPYNPNDRKGKKKMIEIVHFKDALPPLVICVKMDMTGGVFEDNLQSLNLQEGLEYVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FF75</accession>
    <name>A0A6P7FF75_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114329501 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329501</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134431.1">
        <property type="nucleotide sequence ID" value="XM_028278630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FF75"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278630.2">
        <property type="protein sequence ID" value="XP_028134431.1"/>
        <property type="gene ID" value="LOC114329501"/>
    </dbReference>
    <dbReference type="GeneID" id="114329501"/>
    <dbReference type="KEGG" id="dvv:114329501"/>
    <dbReference type="InParanoid" id="A0A6P7FF75"/>
    <dbReference type="OrthoDB" id="8181631at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027729366" evidence="2">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028134431.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14566" checksum="FAC02CB1B5AD0D70" modified="2020-12-02" version="1">MMWPYVRWLVLLVSVLVLQSDWTTAAPNPNGDEMMRLLKLDQMYSSVARPSLRSGPVETEIRPKLVQRAMLRLQELDRLYSDRARPRFGKRTFHNNPKYAPLEYDSQYQQSEQDVGDWLPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFU7</accession>
    <name>A0A6P7FFU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC114329718</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134701.1">
        <property type="nucleotide sequence ID" value="XM_028278900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFU7"/>
    <dbReference type="FunCoup" id="A0A6P7FFU7">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278900.2">
        <property type="protein sequence ID" value="XP_028134701.1"/>
        <property type="gene ID" value="LOC114329718"/>
    </dbReference>
    <dbReference type="GeneID" id="114329718"/>
    <dbReference type="KEGG" id="dvv:114329718"/>
    <dbReference type="CTD" id="32554"/>
    <dbReference type="InParanoid" id="A0A6P7FFU7"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19006">
        <property type="entry name" value="LGIC_ECD_GABAAR_LCCH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000040">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="27"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="237"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_028134701.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="54126" checksum="BF0B93F365558F6F" modified="2020-12-02" version="1">MIVYYFIIFTVNGIDSDTSTARLSSVTQTITELLKGYDNRLRPNFGGDPLDIGMDLTIASFDAISEVNMDYTITLYLNQYWKDERLSFGFDDENLTLSGEFSDRIWVPDTFFANDKHSFLHDVTEKNKLVRLRGDGFIEYGMRFTTTLACMMDLHYYPLDSQNCSIEIESYGYTVVDVVMSWHSTPVRGVEKAELPQFTIIGWETNDRKETLATGTYQRLSLLFKLQRNIGYFIFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRNSLPRISYIKAIDIYLVMCFVFVFAALLEYAAVNYTYWGARAKKKKQQNIRIDARETLTRSSPSNEDIIELRDLRMSPIPSIRNRYSPSYWYTVDLPSLPPSYRMRRTHSPYMYRNAAGFRYRRTRGNVVNQRKVINALRKAASILKPSLPKIRNVNVIDKYSRIVFPVMFLLFNIGYWAYYFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGE5</accession>
    <name>A0A6P7FGE5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114329133</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133962.1">
        <property type="nucleotide sequence ID" value="XM_028278161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGE5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278161.2">
        <property type="protein sequence ID" value="XP_028133962.1"/>
        <property type="gene ID" value="LOC114329133"/>
    </dbReference>
    <dbReference type="GeneID" id="114329133"/>
    <dbReference type="KEGG" id="dvv:114329133"/>
    <dbReference type="CTD" id="80306"/>
    <dbReference type="OrthoDB" id="2286203at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13512">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13512:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028133962.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29863" checksum="904F8F9BA2CE9B7F" modified="2020-12-02" version="1">MTPMKEASPPVSAMATPTNSSGNLVDEFEEAFQHCLNVLTKEEALPTSDKDEVKVEVEQTTLRFIDLARQMEAFFLQKRFLLSALKPEMNVKEDISELRLELARKEELLKRHYEKIAVWQNLLADIQSYSKSPAQSSATPGTSSIPPSPLPSIPGNQTPNQMISNIPATMQQQLQQQQLQQQQQQLQIQQQMQQMQQQQLQQMQVPPGLSAETVGPGMLSPQALFMQQQGMPSPRGPFGQQPPGGILQGPLAYLEKTTSNIGITDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGL8</accession>
    <name>A0A6P7FGL8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sperm mitochondrial-associated cysteine-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327819</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132328.1">
        <property type="nucleotide sequence ID" value="XM_028276527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGL8"/>
    <dbReference type="FunCoup" id="A0A6P7FGL8">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276527.2">
        <property type="protein sequence ID" value="XP_028132328.1"/>
        <property type="gene ID" value="LOC114327819"/>
    </dbReference>
    <dbReference type="GeneID" id="114327819"/>
    <dbReference type="KEGG" id="dvv:114327819"/>
    <dbReference type="InParanoid" id="A0A6P7FGL8"/>
    <dbReference type="OrthoDB" id="5945029at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006464" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132328.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10519" checksum="500C0250ABA39C0F" modified="2020-12-02" version="1">MKNFVVLIVLSFLLVVVLQVEAIRECPPNSHSGCKPCCPDPTCTDRTPTCPPKKPCKELSPPKCQLQCRCNPSHIMNKSTGVCVMPMQCPRPPVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGM0</accession>
    <name>A0A6P7FGM0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327867</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132380.1">
        <property type="nucleotide sequence ID" value="XM_028276579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276579.1">
        <property type="protein sequence ID" value="XP_028132380.1"/>
        <property type="gene ID" value="LOC114327867"/>
    </dbReference>
    <dbReference type="GeneID" id="114327867"/>
    <dbReference type="KEGG" id="dvv:114327867"/>
    <dbReference type="InParanoid" id="A0A6P7FGM0"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028475995" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132380.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="11337" checksum="AB22C50FF8CB5C8C" modified="2020-12-02" version="1">MFRVCVLAMLICAARAGVIGLGGYDGGHGLLASAPVAVAAPVALAHAPVAVAHAPVAVAHGATSWQNNNLLALNPTAVVTKVAAPVAVAAPVYAKVAAPVAVAPWGLGLGHGGYGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH31</accession>
    <name>A0A6P7FH31_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114329361 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329361</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134227.1">
        <property type="nucleotide sequence ID" value="XM_028278426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH31"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278426.2">
        <property type="protein sequence ID" value="XP_028134227.1"/>
        <property type="gene ID" value="LOC114329361"/>
    </dbReference>
    <dbReference type="GeneID" id="114329361"/>
    <dbReference type="KEGG" id="dvv:114329361"/>
    <dbReference type="InParanoid" id="A0A6P7FH31"/>
    <dbReference type="OrthoDB" id="6689315at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028134227.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43208" checksum="24B9679DC6ED049C" modified="2020-12-02" version="1">MHNTKPKVTVNDDYIDLRNFDESHAKNRGNSMSRKSPNRKNKSSMNSLYLKDEHLQKDKELINHGLKNLVTTYNKTKTRLEKTNQPRRIPCLNKRLPTEIRYTSYLEKPADDQHSFKSKSDTSLNRDKIPIRNVSSSAPFSLSKNIIDSNADKVEPFRNKVTMTGNEDMNDKTRVLTPSKRKQKSHCRSKSRDGDIRDTAKCVVQTPYQNGRKSNDCLNRPIDPRLKEKYSILHVPCVKRSWSIPIFSSKTSVHGTKGNDNYDRQTYLYDDGSEIESAYLTQKTNFNKECPREFTVVLFTMGAVCGILLASLLIYIIFGNDVLHVFFKQREPPDASIKSYVKYVGGGLIYIITRFFKVMGEVLSIPVNKKEDYLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH74</accession>
    <name>A0A6P7FH74_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114329387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329387</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134272.1">
        <property type="nucleotide sequence ID" value="XM_028278471.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517991.1">
        <property type="nucleotide sequence ID" value="XM_050662034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH74"/>
    <dbReference type="FunCoup" id="A0A6P7FH74">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662034.1">
        <property type="protein sequence ID" value="XP_050517991.1"/>
        <property type="gene ID" value="LOC114329387"/>
    </dbReference>
    <dbReference type="GeneID" id="114329387"/>
    <dbReference type="KEGG" id="dvv:114329387"/>
    <dbReference type="InParanoid" id="A0A6P7FH74"/>
    <dbReference type="OrthoDB" id="8188414at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41155">
        <property type="entry name" value="FI19525P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41155:SF1">
        <property type="entry name" value="FI19525P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028134272.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32626" checksum="65E5B9BC6A50C9F5" modified="2020-12-02" version="1">MARRVAKNHYVASPRHHHSPTPVHVSRNAAYSDGEESQRAPSERTLSEYTSVPYTIVNERNGRRYNNHQKSSSYQNGQNTSTPMRAPSALSRGSGYETNGSDIYVTSGAYKAPSEISRNSRIRAPSHMSYRSGIAPSVTSTHKSRGSRKAGMRMEAMAAPNPFCPNIKGMCCLMLLLNFGIILVTLGMVIVIQFYDPLYVWVLGIIFLIFGFLTLVCSLIYCVVICREFKRPGDVNPDELYWTHHWQKSIGTVPEIHYKAEEKYGDDRYSDRYSVSKLSGKYSDKNGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJA2</accession>
    <name>A0A6P7FJA2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114330823</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028136036.1">
        <property type="nucleotide sequence ID" value="XM_028280235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJA2"/>
    <dbReference type="FunCoup" id="A0A6P7FJA2">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651671.1">
        <property type="protein sequence ID" value="XP_050507628.1"/>
        <property type="gene ID" value="LOC126885218"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FJA2"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028136036.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40294" checksum="D115B679E18FF724" modified="2020-12-02" version="1">MGSAQSALNFGAGPAKLPREVLEEVQKEFLSYQDSGMSLIEMSHRGKEYTKINKDSQAVIRELLNVPDNYKILLMQGGGCGAFAAVAMNLLNRTGTADYAVTGTWSDKAAKEASKYGNVNLVFPKASKPGSVPPQNTWKMNPNASYVYYCDNETVDGVAFHYIPETNGVPLVTDMSSSIMTKKLDISKFGCIIAGAQKNIGPAGVVVVIVREDLLGNPMKCCPSVMDFTHIAKENSVHNTPATFSVYVMEKVLQWIKKNGGLEAMENQAIEKSSLLYNAMVESKGFYTCPIDEDVRSRMNVPFRVGGGNEKLEELFLVEAEKVKMYQLKGHRSVGGIRASLYNAVTLDDVKLLVKFMKEFQAQHGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK06</accession>
    <name>A0A6P7FK06_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114330227</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028135352.1">
        <property type="nucleotide sequence ID" value="XM_028279551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK06"/>
    <dbReference type="FunCoup" id="A0A6P7FK06">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279551.2">
        <property type="protein sequence ID" value="XP_028135352.1"/>
        <property type="gene ID" value="LOC114330227"/>
    </dbReference>
    <dbReference type="GeneID" id="114330227"/>
    <dbReference type="KEGG" id="dvv:114330227"/>
    <dbReference type="InParanoid" id="A0A6P7FK06"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028253502" description="Lysosomal Pro-X carboxypeptidase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028135352.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="54008" checksum="6A9FB00216D54574" modified="2020-12-02" version="1">MRWEIVCFVGVLAIVLAEDNYLFETKYIDVPLDHFSFAQDTKFQLRYLINDTYHEDRGPIFFYTGNEGDIKNFAKNTGFMYDIAPTFSALLVFVEHRYYGESLPFGNQSYSSIDKLGYLSSQQALADFVYVIEALQEQYAHNQKNLPVIAFGGSYGGMLSSWIRMKYPSSVLGAIASSAPIWQLGGLTSCEIFNRITTSVYASFGTDKCTNGITNVWKTIRSFTKTAEGKANLTSTWNLCSPIKTDDDINQLIDWAAELIVNMAMVNYPYPTNFLADLPAYPVREFCNRLNSHKLNGDYDLLVAVVDGLGVYTNYTKTAKCNNINVTSPSLSDNGWNFQSCTDMIMPMCSQSSDMFENANWDFAEFSDTCYKQFKVRPRNLNVPLLEYGGKDIEAASNIVFSNGLLDPWSGGGVLRNINDRVRSIIIPDGAHHYDLRGKNDLDTEDVKYARNFHVRKIKEWLREYYSDPQVNLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLD2</accession>
    <name>A0A6P7FLD2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Transcriptional regulator Myc-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC114331443</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136825.1">
        <property type="nucleotide sequence ID" value="XM_028281024.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136826.1">
        <property type="nucleotide sequence ID" value="XM_028281025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLD2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281024.2">
        <property type="protein sequence ID" value="XP_028136825.1"/>
        <property type="gene ID" value="LOC114331443"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281025.2">
        <property type="protein sequence ID" value="XP_028136826.1"/>
        <property type="gene ID" value="LOC114331443"/>
    </dbReference>
    <dbReference type="GeneID" id="114331443"/>
    <dbReference type="KEGG" id="dvv:114331443"/>
    <dbReference type="OrthoDB" id="5964374at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11400">
        <property type="entry name" value="bHLHzip_Myc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000019">
        <property type="entry name" value="Myc proto-oncogene protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050433">
        <property type="entry name" value="Myc_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002418">
        <property type="entry name" value="Tscrpt_reg_Myc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45851">
        <property type="entry name" value="MYC PROTO-ONCOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00044">
        <property type="entry name" value="LEUZIPPRMYC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="370"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028136825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028136826.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52427" checksum="81B6E10B9CFBD07E" modified="2020-12-02" version="1">MPVKFEDVFDFGPKMNLIDYLTDDTSNPISDFLLPDDIWNKFEIDLSDWTALDSILADASKITDDLLCPLGGHPEIRNHDCMWAGHCASKEHPADEPRMSTGCIIPVPPPIMKPPVMEIKQENPKPSGQQSLLKSHVRAAAPAILQTPPMSDDEEAKAKSSNILKLLHDAIDEYDIEADSDLSDYFKDKDLKDEEEEEEEEEEEEEEVEIKIEEHDVKPSVSRLYHAAESDHSYHKGKQSAMQMATFGIETPSDSEEEIDVVNVNNEKFPFNKTAVFSFPNNPSTKDRQQIQMRMATAISKKRIQAQAQGIKTIMPVRKTATPEASPIKRKPVETTRSGKKTRQYRTPVSTPYKRRQYGNSSDSEPEPSEKRSLHNNMERQRRIDLRNAFEDLRVLVPEVSKKERAAKVVILREAAQYCDFLTNTSTKYSKHFDELKKKQEFLRRRVSQLRRNLAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNF6</accession>
    <name>A0A6P7FNF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger CCCH domain-containing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114331056</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZC3H15/TMA46 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136332.1">
        <property type="nucleotide sequence ID" value="XM_028280531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNF6"/>
    <dbReference type="FunCoup" id="A0A6P7FNF6">
        <property type="interactions" value="2528"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280531.2">
        <property type="protein sequence ID" value="XP_028136332.1"/>
        <property type="gene ID" value="LOC114331056"/>
    </dbReference>
    <dbReference type="GeneID" id="114331056"/>
    <dbReference type="KEGG" id="dvv:114331056"/>
    <dbReference type="InParanoid" id="A0A6P7FNF6"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000050">
        <property type="entry name" value="AGAP008634-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028136332.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="45155" checksum="95421B2D8D7D5CCB" modified="2020-12-02" version="1">MPPKPKPGAPSKKTEQKKKEKVIEDKTFGLKNKKGAKQQKFIQQVEKQVKSGGIHPLGTAVDQKKLEKEKKLKEQKELAALFKPVQIQKIDKGADPKSVVCAFFKQGQCGKGDKCKFSHDLAVERKAEKRSLYFDMRNDEDDNDTMENWDEAKLKEVIEKKHGEKGKMPTTDIICKHFLEAVEKSKYGWFWTCPTGEGCIYRHALPPGFVLKKDKKKLEDKANEITLEDLIEKERAALGPNQTRITLETFLAWKKRKIQEKKDQLKKDEDKKRNEFKAGRQVGLSGREMFSFNPDLATEYDMEDGDELFDSTAYPTEEEDAIVYKEIDLSIIGDDVQEVDGTGTVATEDRFKDVKPTTSDEKPAEGATAVAINENLFLESDLEDLDEELQELDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNV5</accession>
    <name>A0A6P7FNV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114332268</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137836.1">
        <property type="nucleotide sequence ID" value="XM_028282035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282035.2">
        <property type="protein sequence ID" value="XP_028137836.1"/>
        <property type="gene ID" value="LOC114332268"/>
    </dbReference>
    <dbReference type="GeneID" id="114332268"/>
    <dbReference type="KEGG" id="dvv:114332268"/>
    <dbReference type="InParanoid" id="A0A6P7FNV5"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF254">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028137836.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72903" checksum="2248560A473D69D0" modified="2020-12-02" version="1">MTNCKKKVLYDTMSNKVYVWDDHMQITAPPEKKPFILSGKPEEKSPDRNVEEERGGWGNKLDFLMSCISLSVGLGNVWRFPYLCYKNGGGTFLITYHIAMFICGIPLFFQEIAIGQYLGSGGMTFVGQLCPILKGVGYASMTIVFFLDVYYCVIIAWTLFYIFSSFSSTLPWSECEMLLSDIRMSLVRDAMSTHQIRSVNNNSNTLGQWWNSENCFVKDNTTTFNVSSIISRNSSSAVEEFFDRRVLSITSGLEDIGGFQWHLFIALIVGWIMVYGIIRKGLHQSGKIMWFTACFPYVILLIMLVRAVTLEGAGTGLLYYITPQWEALLTPGPWMDGASQILFAYSIGCGALPALGSYNTFHHNSYKDAVITCIVNTSTSVIAGIVTFSILGHLALEQNTEVGSVVNSGPGLVFITYPQVVLRLPGSSFWAAIFFFMLLLLGIDSEFCLVESFITGILDNWSQSLRPHRHLFTLAVCVVMFLLGIPMITQGGMYIFQLVDYYSASGMSLLWVCFFQTIAISWFFGVDRLGDCIEKMMGIRPGLFWRISWKYIAPILMAVIFISQCFEYQRLSYGSYEYPLWADIIGLGISFSSMLWIPVYIIYYVFSQPGSLLENFKKGLKSNIAQRKVSVCDKSTGELLSQSQNNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPM4</accession>
    <name>A0A6P7FPM4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane emp24 domain-containing protein bai</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114331366</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136722.1">
        <property type="nucleotide sequence ID" value="XM_028280921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPM4"/>
    <dbReference type="FunCoup" id="A0A6P7FPM4">
        <property type="interactions" value="2280"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280921.2">
        <property type="protein sequence ID" value="XP_028136722.1"/>
        <property type="gene ID" value="LOC114331366"/>
    </dbReference>
    <dbReference type="GeneID" id="114331366"/>
    <dbReference type="KEGG" id="dvv:114331366"/>
    <dbReference type="CTD" id="42996"/>
    <dbReference type="InParanoid" id="A0A6P7FPM4"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028169232" evidence="10">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028136722.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23545" checksum="5E4E318F924926C9" modified="2020-12-02" version="1">MDFSHCFLVFISLIVCTNCIMWNLKPNSRKCLREELQQNIPVVGEFDVSEAPGQTVNYVVTDSKGHILAKREAISKGKFSFNTESFDTYEICFISQVAPHIAGVTQEVSLITKHGIETKNYDTYGEAAQLKPIEKELKRLEDLSDAIVQDFAIMRKREEEMRDTNESTNSRVLYFSIFSLCCLMGLATWQVLYLRTYFKAKKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRF1</accession>
    <name>A0A6P7FRF1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease inhibitor dipetalogastin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114330420</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135563.1">
        <property type="nucleotide sequence ID" value="XM_028279762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRF1"/>
    <dbReference type="FunCoup" id="A0A6P7FRF1">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642057.1">
        <property type="protein sequence ID" value="XP_050498014.1"/>
        <property type="gene ID" value="LOC126879111"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FRF1"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000067">
        <property type="entry name" value="Thrombin inhibitor rhodniin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028229464" evidence="4">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028135563.1"/>
        </source>
    </evidence>
    <sequence length="67" mass="7497" checksum="BD4D3A859D95D805" modified="2020-12-02" version="1">MKIFPFISLCLCLLIVISQADPTFGCDCQLIYHPVCGTDGKTYDNKCGLECEQKDNPDLKIKHEGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FT38</accession>
    <name>A0A6P7FT38_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pupal cuticle protein C1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332360</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137947.1">
        <property type="nucleotide sequence ID" value="XM_028282146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FT38"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282146.1">
        <property type="protein sequence ID" value="XP_028137947.1"/>
        <property type="gene ID" value="LOC114332360"/>
    </dbReference>
    <dbReference type="GeneID" id="114332360"/>
    <dbReference type="KEGG" id="dvv:114332360"/>
    <dbReference type="InParanoid" id="A0A6P7FT38"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006413" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028137947.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7400" checksum="FDA60B9FD82BDDCA" modified="2020-12-02" version="1">MFKIFAFLFAILAVAFAAPKAQPVPQVLAAYSAPAVVSSYSYPYAAASYAAPVAYSAGYGSLAYSAPLAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWQ9</accession>
    <name>A0A6P7FWQ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114331843</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137318.1">
        <property type="nucleotide sequence ID" value="XM_028281517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWQ9"/>
    <dbReference type="FunCoup" id="A0A6P7FWQ9">
        <property type="interactions" value="3098"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281517.2">
        <property type="protein sequence ID" value="XP_028137318.1"/>
        <property type="gene ID" value="LOC114331843"/>
    </dbReference>
    <dbReference type="GeneID" id="114331843"/>
    <dbReference type="KEGG" id="dvv:114331843"/>
    <dbReference type="InParanoid" id="A0A6P7FWQ9"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028137318.1"/>
        </source>
    </evidence>
    <sequence length="1052" mass="120785" checksum="27B56B82EC62D043" modified="2020-12-02" version="1">MAELLDFSQKLNIKLLDNVVISMYAGKGESQRIAQEVLTTLKEHPDAWTRVDTILEYSTNQETKYYALQILEQVIKTRWKVLPRNQCEGIKKYIVSLIIKTSSDPEVFESNRTYLNKLNMILVQVLKREWPKNWESFIPDIVGASKTNESLCQNNMIILKLLSEELFDFASGQITQTKAKHLKDTMCSEFSAIFHLCQFVLENSQNPPLVNATLETLLRFLNWIPLGYIFETSLINTMIFKFLPVPMFRNVTLKCLTEIAGVTVSNYDDMFGALFTQTMAQLEMMLPLQTDIKGAYACGQDSEQNFIQNLALFLCTFLKEHTSIAESQVHNLGKALRYLLLISEVEDVEIFKICLEYWNSFAFQLYQEVPHGIAIFANKAKDYGNFYHDLYKEVLNKIRYIMISRMAKPEEVLVVENDNGEVVREFMKDTDSINLYKNMRETLVYLTHLDCADTESIMTNKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLALCEQKRGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIALKCRRHFVTTQIGESCPFIEDILASIPTIICDLQQQQVHTFYEAVGYMISAQVDTATQEALIEKYMMLPNQVWDDVISKASKNVDFLKEIEIAKQLTSILKTNVRACKALNHAYVLQLGRIYLDMLNVYKVMSKNITAAILLNGEAVVKQPLIKSMRAVKKETLKLISDWISRSTDNTMVLDSFIPPFLDAVLLDYQRTPVPLAREPEVLSAIATIVNRLEGHITMEVPKIFDAVFECTLEMINKDFEEYPEHRTNFFLLLQAVNNHCFGAFLNIPPTQFKLVLDSIIWAFKHTMRNVADIGLQILLKLLQNIEQHESAAPSFYQTYLTDILQHIFSVVTDTSHSSGLSMHATILASIFTLVESGGVNCQLGPRPDNVLYIQEFTATLLKSAFPHLTDNQIKITVQGMFNLDQDIPQFKEHLRDFLVQIREYTGEDDSDLFLEEREKALEIAQAEKRRIELSVPGILNPHEVPEEMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FY53</accession>
    <name>A0A6P7FY53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114335465</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with YBX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028141509.1">
        <property type="nucleotide sequence ID" value="XM_028285708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FY53"/>
    <dbReference type="FunCoup" id="A0A6P7FY53">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285708.2">
        <property type="protein sequence ID" value="XP_028141509.1"/>
        <property type="gene ID" value="LOC114335465"/>
    </dbReference>
    <dbReference type="GeneID" id="114335465"/>
    <dbReference type="KEGG" id="dvv:114335465"/>
    <dbReference type="InParanoid" id="A0A6P7FY53"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000103">
        <property type="entry name" value="Putative deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="16">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028141509.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35512" checksum="4431C1D030B8CEDA" modified="2020-12-02" version="1">MPSTQERNPGCELDLGWVNSINVNLRATNELAKNIVASRELKGEYRAAWILKAITLIDLTTLGGDDTKSNVTRLCFKAARPVAEDILNELGFEYNEDSPIHTAAVCVYPSRVADAVKALGDMGMLGKINVAAVATGFPSGQYPINTRLEEIQYAVKNGAKEIDIVIDRSLVLTGKWQELYQEIQVMKEACGPDAHLKAILATGELGTLDNIYKASLIAMMAGSDFIKTSTGKEAVNATLPVGLIMARAIKDYFDRMGYKVGLKPAGGVRTASDAINWLVLIKETLGNDWLNSELFRFGASGLLGDLESSLYQYVTGKTPAGYEFMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G076</accession>
    <name>A0A6P7G076_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC114334593</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140467.1">
        <property type="nucleotide sequence ID" value="XM_028284666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G076"/>
    <dbReference type="FunCoup" id="A0A6P7G076">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654807.1">
        <property type="protein sequence ID" value="XP_050510764.1"/>
        <property type="gene ID" value="LOC126887352"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G076"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000195">
        <property type="entry name" value="AGAP006273-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF17">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="20">
        <location>
            <begin position="113"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="437"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_028140467.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="75108" checksum="B6836784EEC84254" modified="2020-12-02" version="1">MWRLIQQNLHNKLLFHNSAIFKKYFCQGHIKNYISRTVSQKPVPKSFIPSKVATFGVTLTGGLIIKLYISHNGVLCEAKKTRMAGYENKSDKNVKFDWARLWKYLKPHIWYFLAAIVGALAVALLNIQIPQVIGGVVNVLAKFSESRDSELFLNEMKRPVIKLISMYLAQSVCTFFYIFMLSNLGERMAYKMRTDLFESILKQDIAFFDQQRTGEIINRLTADVQDFKSSFKQIVSGGLRAATQIVGCSVSLIMLSPQMTFISLLCIPSVIAVGTVFGSLLRSVSRRAQAQVEKTTAVADEAVSNIRTVRAFAMEDQEKELFNTEADRAMVLNEDLGLGIGLFQAGTNMFINGMVLSTLYMGGYLLSTNQLSAGEVMAYLVASQTIQRSLAQISLLFGSVVRGVAAGSRVFEYINKTPKMALTGGKVLPYESVKGDIEFKNVCFAYPTRSQQIILQGFNLSVPSGKTVAIVGASGNGKSTVVALLERFYDVKDGSITLDGHDIRSLDPSWLRGRVLGLISQEPVLFGTTIMENIRYGKPDASDDEVKEAALLANADEFITSFPKGYNTPVGERGVTLSGGQKQRIAIARALLKNPVVLLLDEATSALDTESEKIVQQALERARTGRTVIVIAHRLSTIQNADLIVVLNKGKIVEMGTHESLKKLGGYYWSLAYQQQNSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G114</accession>
    <name>A0A6P7G114_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lys-63-specific deubiquitinase BRCC36-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114336386</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. BRCC36 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142546.1">
        <property type="nucleotide sequence ID" value="XM_028286745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G114"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286745.2">
        <property type="protein sequence ID" value="XP_028142546.1"/>
        <property type="gene ID" value="LOC114336386"/>
    </dbReference>
    <dbReference type="GeneID" id="114336386"/>
    <dbReference type="KEGG" id="dvv:114336386"/>
    <dbReference type="InParanoid" id="A0A6P7G114"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08068">
        <property type="entry name" value="MPN_BRCC36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040749">
        <property type="entry name" value="BRCC36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033860">
        <property type="entry name" value="MPN_BRCC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18110">
        <property type="entry name" value="BRCC36_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142546.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="29143" checksum="061F8F4674849FA9" modified="2020-12-02" version="1">MISENYLKRVNITADVYAICVQHALTTEKQEIMGLLIGEVNESERVSNISACVILHRSDKQPDRVEISPEQLCHASMHADQLAKKLNRPMRVLGWYHSHPHITVWPSHVDIRTQATYQTMDPLFVGLIFSVFQNDTRSRRNQIQVTCFQAHNSTSELERREVELVIKPSPFENYNLEGIANLPKILVQEEVDCHDIQDNDTQDELSSLHNDAFKTLALVHIVAKVARPICDDLEERKKSVIQRIKELEKLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2K6</accession>
    <name>A0A6P7G2K6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19 20 21" type="primary">LOC114335237</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19 20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028141238.1">
        <property type="nucleotide sequence ID" value="XM_028285437.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141239.1">
        <property type="nucleotide sequence ID" value="XM_028285438.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141240.1">
        <property type="nucleotide sequence ID" value="XM_028285439.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141242.1">
        <property type="nucleotide sequence ID" value="XM_028285441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2K6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285437.2">
        <property type="protein sequence ID" value="XP_028141238.1"/>
        <property type="gene ID" value="LOC114335237"/>
    </dbReference>
    <dbReference type="GeneID" id="114335237"/>
    <dbReference type="KEGG" id="dvv:114335237"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000685">
        <property type="entry name" value="Serine/threonine-protein kinase dyf-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000071">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028141238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028141239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028141240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028141242.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="63662" checksum="5BEA0A62F36E7365" modified="2020-12-02" version="1">MNRYTILHQLGDGTYGSVVLGQRKDTGEKVAIKRMKRKYYSWDEAMNLREVKSLKKLHHSNVVKLKEVIRENDVLYFVFEYMQENLYQLIKDRRVPFPESVVRNIIYQILQGLSFIHRHGFFHRDLKPENILCSGTEMVKIADFGLVREIRSRPPYTDYVSTRWYRAPEVLLHSTTYSSPIDLWALGCIAAEIYTYRPLFPGTTETDQLYKICALRGTPDENKWPESYQLAGALGFKFPYFAKTPVSDVVPQAGPNGINLIDELLEWNPGHRPTAHGALKHQYFQVGQFSALQANRQIQANSALQSHSNGIIQKIPAQASIDQEDSQMYPNPQPQLQIQANGRSLIKQLSNANLPPMQPSVQINIQSLIKPMEPAMEKARLQAPPIVYSFGQSDYGSKYLPSVFSTMNNMGNRVVVPNKKITWGMETNFEYEDDFADILGSKIKLPPADKKKENSKVNLSQFNLQDILEPLAKASAGTIRNQYLNVPKYMNGQSTVRRDSNISLFSNFSNSGRNSGMQNKQASKLDLQPMWTDFGDLSSAKRRFGNIKISNTNGYDLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6L8</accession>
    <name>A0A6P7G6L8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114336464</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028142642.1">
        <property type="nucleotide sequence ID" value="XM_028286841.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513958.1">
        <property type="nucleotide sequence ID" value="XM_050658001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6L8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050658001.1">
        <property type="protein sequence ID" value="XP_050513958.1"/>
        <property type="gene ID" value="LOC114336464"/>
    </dbReference>
    <dbReference type="GeneID" id="114336464"/>
    <dbReference type="KEGG" id="dvv:114336464"/>
    <dbReference type="InParanoid" id="A0A6P7G6L8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028510817" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="31"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028142642.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="62121" checksum="BF90D008605016BB" modified="2020-12-02" version="1">MAHLNLFVFCALVNFANNGVTSAVTGLTDDDLIITLSTGSKVRGHVLQSFEGNNFHAFESIPYAEPPIGKNRFQPPVIKTPWEGILNATANEKMCPQLLSHNDPVVIGEEDCLILNVYTPLKSDLQTPLPVFFWIYGGGFDSGHSALYDPRLLIDFDIVIVTINYRVGSLGFLTTIDDNIPGNVGLKDQLLALQWVHDNIIAFGGDPKQVTVGGESAGSMSAGFHLLSKAAKGLYSGIIQQSGSPLAGPFYPSNDREIAFEFGRQLNKSFTSSRSSDLLAMLQEASLTDILNLQATFSVGVRPQGFMSTIVWKPVIEEEFNDKAFVTGPMHSAILNGDFNFVPVLIGLNSEESLLFFNDVDEEEFNQTAKFFDENTKDIISISLNIAEEFRENVGKTLKSLYTNTSFQEDSLGFIKYSSDEVFGRSIIRQAEGASRYVPVYMYQLSWYNKNNRFPGTGHAYDLYYLWNLSVDSSGYNDSLRKPILKWWTNFIKYQNPTPVEDKDLQNIIWPEVKPGSVKYLNIDSTFEVQENPRRYYQIESILDPYTREPLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAU1</accession>
    <name>A0A6P7GAU1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase CHFR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114335878</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHFR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141963.1">
        <property type="nucleotide sequence ID" value="XM_028286162.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505655.1">
        <property type="nucleotide sequence ID" value="XM_050649698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAU1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649698.1">
        <property type="protein sequence ID" value="XP_050505655.1"/>
        <property type="gene ID" value="LOC114335878"/>
    </dbReference>
    <dbReference type="GeneID" id="114335878"/>
    <dbReference type="KEGG" id="dvv:114335878"/>
    <dbReference type="InParanoid" id="A0A6P7GAU1"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028141963.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52259" checksum="1464EF25096B12D7" modified="2020-12-02" version="1">MDTGHPLLVNNSDHASIEINQSPFTLGRGLNCNCLITSPLVSREHCSLEKTANGWCVRDKSTNGTYVNQTSIKGVLSDPLKSGDVIQLSCHHKYTFQNGPNDDSISDEQLCRIADTVLETIEVAADTSLSAPPPEPYPVTLQLDVYPDSSVPRPIRHPVSDTFQPSKRLKTINLIPSTSVSTNVIDLTVDNFIEIENRRDPSTSTNVNGESLETITLDDSSIQVISTTVPSATEMVTVETVCSVEVQSSKINNSQTACTSDTNMGQIESHKPESDSNMMSESQMENELQCAICAEMFVKASTLNCSHTFCKFCIDKWKEKQTICPICRTKITSQVPTLVLDNFIEKIIQGSAQDIQDHRRELLNERAQMQKHQQNLLEQQQQPRSDTRRQGRGRRVQVAFDPEPVVMDGDDSSSSSDTTSTESDSGQEDAEFEDNYWNDDWYNNAYYGGYGRCFTCGRRGHWANGCPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GB90</accession>
    <name>A0A6P7GB90_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adapter molecule Crk</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114335615</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141680.1">
        <property type="nucleotide sequence ID" value="XM_028285879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GB90"/>
    <dbReference type="FunCoup" id="A0A6P7GB90">
        <property type="interactions" value="1240"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285879.2">
        <property type="protein sequence ID" value="XP_028141680.1"/>
        <property type="gene ID" value="LOC114335615"/>
    </dbReference>
    <dbReference type="GeneID" id="114335615"/>
    <dbReference type="KEGG" id="dvv:114335615"/>
    <dbReference type="CTD" id="1398"/>
    <dbReference type="InParanoid" id="A0A6P7GB90"/>
    <dbReference type="OrthoDB" id="9204160at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09926">
        <property type="entry name" value="SH2_CRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11759">
        <property type="entry name" value="SH3_CRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035458">
        <property type="entry name" value="CRK_SH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028141680.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30185" checksum="1D4E94E9364CFD16" modified="2020-12-02" version="1">MASSFDHEDKDSWYFGAIGRHEATNLLMDEREGGVFLVRDSATCVGDYVLCVKEDSKVSHYIINKTQAQDQSRYKIGDNFFKNIPELLSFYKVHYLDTTPLIRPASKRVEKVIAKFDFDSSERDDLSFKKGDILTIVFKDEEQWWTARDKNGRTGSIPVPYVQKIEENHSPVEIPRPGSGGPVSNTSLQAEAAKRNQMQRKLPAKARVKQVRIPNAYDETALKLEIGDVITVTKTNINGQWEGELNGKSGYFPFTHVEFLDEENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFA4</accession>
    <name>A0A6P7GFA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Torsin-1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341677</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148286.1">
        <property type="nucleotide sequence ID" value="XM_028292485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFA4"/>
    <dbReference type="FunCoup" id="A0A6P7GFA4">
        <property type="interactions" value="1061"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662694.1">
        <property type="protein sequence ID" value="XP_050518651.1"/>
        <property type="gene ID" value="LOC126892876"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GFA4"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002370">
        <property type="entry name" value="Torsin family 3, member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028073418" evidence="2">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148286.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37616" checksum="CE3B1EB13FE0D5E2" modified="2020-12-02" version="1">MAVTKVTYLFLIFTLCIQLVHPIIWNPLCWFGECCNKNDIIDDIQRLRATMKRKVYGQHLAESAVDAIQSHLYFKPDKPLTISFHGWAGSGKNYVSSFIAENLYKHGVKSKFVQTFIGRLHFPEASKVYGYKRDLYNWIKGNVSSCSRQLFIFDEVDKMPTDLLNAIKPILDHKGLVEGVDYTRAIFIFLSNTGSNIINQHYLDLWNSGRQRENMKLSDFESLVMKGAFTEKGGFQFSDVVKSNLIDHYIPFLPMQEAHVKECIKDQFRERGITNPTDDDIKEIMSFIEWGPEGVNLFSKTGCKRISAKVGKLVVRKYPEKLRYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFB3</accession>
    <name>A0A6P7GFB3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 583-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114341688</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148296.1">
        <property type="nucleotide sequence ID" value="XM_028292495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFB3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653507.1">
        <property type="protein sequence ID" value="XP_050509464.1"/>
        <property type="gene ID" value="LOC126886552"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GFB3"/>
    <dbReference type="OrthoDB" id="6219989at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF242">
        <property type="entry name" value="ZINC FINGER PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028148296.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="49552" checksum="64C92A0EF153766A" modified="2020-12-02" version="1">MEVKQEFSEDTCNIEFFSNKLDDAFIDSFKNDIKEEPSRETTYYDTFHCLDLKEFPIKTELEDENQLVPFEEKQNNKKGYPQETGPLEIVKNIDIHSCNKEQPTNELAKEKILQCEICLKQFTRTNNLKTHLRVHSGEKPFNCEICSKQFTHKNSLKIHTRCHTGEKPYECEICLRQFSEAGSLTIHMRVHTGEKPYKCKICFKQFSQPGSLRKHLKVHTGGKPYQCEICLKQFRHAETLKKHLRVHTGEKPFECKICFKQFTRTSYLKAHLRVHTGEKPHKCDICFKNFTRLYLLKSHLKVHTGEELHKCEICFKQFSERGSLKRHLSVHTGEKPFECKICLKQFSRAETLEKHMKMHTGEKPYKCEICFKQFARKDYLNRHMHAHTGEKPYKCEICFKLFSEKGILKRHMKVHTVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GI27</accession>
    <name>A0A6P7GI27_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114342928</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028149536.1">
        <property type="nucleotide sequence ID" value="XM_028293735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GI27"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293735.2">
        <property type="protein sequence ID" value="XP_028149536.1"/>
        <property type="gene ID" value="LOC114342928"/>
    </dbReference>
    <dbReference type="GeneID" id="114342928"/>
    <dbReference type="InParanoid" id="A0A6P7GI27"/>
    <dbReference type="OrthoDB" id="6723085at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028161382" description="acid phosphatase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028149536.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46009" checksum="E715F63CA9CBD9DF" modified="2020-12-02" version="1">MFLQIQFLVLLFWAAIAASDQTVLEGSASNLTASNQLVAVVQIFRHGHRTPTVFYKNDKYADLSKYWNGLNLGDLTNEGKRQHYRLAMFTRMRYGKWLPQNYNKNDFYAQTTEYDRTHMSGQVNIYGLYPSKLDQRWRLLTDWQPIPLHPGDANIWESIPKCAAYTGEYAKVLASDRYAAINKQYADVYAYLSKYSGNNVTNVEQAYPVFDSFKSESTVGLRLPVWASKVYPEPLRELIGHMFNAYVYTTKQQRLYAGALLDSILNYFDNKINGSVSQKFKMYSGHDLNVAGILRVFGAFNPPYPPDFASSLYLELRNNSGSYFVNAWSKDGSNFNQVSIKGCALDCPLDEVRQRLDGILLDVDTKVKECNAKLEFENVDVENMYKKLTETGEMERLKDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQU2</accession>
    <name>A0A6P7GQU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339672</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114339672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146140.1">
        <property type="nucleotide sequence ID" value="XM_028290339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028290339.2">
        <property type="protein sequence ID" value="XP_028146140.1"/>
        <property type="gene ID" value="LOC114339672"/>
    </dbReference>
    <dbReference type="GeneID" id="114339672"/>
    <dbReference type="KEGG" id="dvv:114339672"/>
    <dbReference type="InParanoid" id="A0A6P7GQU2"/>
    <dbReference type="OrthoDB" id="6760427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027729786" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028146140.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25459" checksum="A22907E46D864C67" modified="2020-12-02" version="1">MNKFIVLFAFVVAIGTTHAASVSSSSSSSEEDIAEIAQLLNKRFNSTIILDVIKMAEKAKDKCPNIEDKIDEVVEKVDKCMDDIELGSETFCSLVKKNLAKCSKPLIDLITSCLPEESKDLPVLGQKIITAIVDEACHTTVEELLELFNPCFMEKEFVSVPACSEIKDVFVANRNKLPSKSLVCSMLPKVKSCVKGHVDASCQNPTTKRATLKFHEAIDNAIKSDCDALNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR37</accession>
    <name>A0A6P7GR37_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114341122</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114341122</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147703.1">
        <property type="nucleotide sequence ID" value="XM_028291902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR37"/>
    <dbReference type="EnsemblMetazoa" id="XM_050662144.1">
        <property type="protein sequence ID" value="XP_050518101.1"/>
        <property type="gene ID" value="LOC126892581"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GR37"/>
    <dbReference type="OrthoDB" id="3066195at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147703.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16766" checksum="8C5D3A0908853B68" modified="2020-12-02" version="1">MNEEYIIIDEPIKNENRQQNDPESLIGQEDWSTYTPKMLKQKKAEPLRLGTKKNLKNTVAKWGQAKEGHIRQQNLCLKAQHERKMLIMGIVAKKKITMMEEEAARNKLEHEKRMELMEKTMALIEQEAEERKEIMKKYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GRB1</accession>
    <name>A0A6P7GRB1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114345802</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114345802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152396.1">
        <property type="nucleotide sequence ID" value="XM_028296595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GRB1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645444.1">
        <property type="protein sequence ID" value="XP_050501401.1"/>
        <property type="gene ID" value="LOC126881265"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GRB1"/>
    <dbReference type="OrthoDB" id="6765513at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF10">
        <property type="entry name" value="IP19903P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028280079" evidence="1">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028152396.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24206" checksum="98262B450C069FBF" modified="2020-12-02" version="1">MCLYTKMIAKTLCFLLVLFYSHQAYGRSSQGDLLEWQDYDPDTIPDDAIPSGETMDNEDIYIGLVHFSNEKFEGFIPTNIVAGRKCVHIVVGLEDIEKICDNIKILVGKNDYLDKIYWEYARPSYFGSLFDSDDFRPVRAGWEVQSLSYNSSVYLGRQYFGGQNWVGKIYNSYPKEDENGVTVFSYEQYRSPDTVEIGKGALFEVLLFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GWN9</accession>
    <name>A0A6P7GWN9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC114343209</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149817.1">
        <property type="nucleotide sequence ID" value="XM_028294016.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028149818.1">
        <property type="nucleotide sequence ID" value="XM_028294017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GWN9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647248.1">
        <property type="protein sequence ID" value="XP_050503205.1"/>
        <property type="gene ID" value="LOC126882357"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647249.1">
        <property type="protein sequence ID" value="XP_050503206.1"/>
        <property type="gene ID" value="LOC126882357"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028149817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028149818.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24609" checksum="3E0E001A20BBE721" modified="2020-12-02" version="1">MAGEQDMPTFKCVLVGDGGTGKTTFVKRHMTGEFEKKYVATLGVEVHPLVFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAAPALLPPEVQMDPQWQQQIEKDLKEASETALPDDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GXA7</accession>
    <name>A0A6P7GXA7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450 4C1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114344049</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150702.1">
        <property type="nucleotide sequence ID" value="XM_028294901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GXA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646089.1">
        <property type="protein sequence ID" value="XP_050502046.1"/>
        <property type="gene ID" value="LOC126881682"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GXA7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028150702.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="57644" checksum="4E90AB9EE09FA207" modified="2020-12-02" version="1">MYILLLVLCVIAIFLFRQYTYHKYWKYVNEIPGPETFPIIGNYELVNLENEELFRILRERSKLFYPIYKIWGLFELYLISLAGPPEDMELILGHSENNNKSFVYRLLNNWLGTGLLTSNGSKWHSRRKILTPAFHFNILQKYLEVFNKETEILLDELDKDAGKEYINVVKPMTDFTLFSIGESALGVSLREKNCDEYKKAVHAYGKMATYRILKPLLYQDFIFNMLPIGRALKKYVLKTLHDLSTNIIREREQSKQMDAQGNFSYSKRKRLALLDLMLEARAAGEDIDEKGIKEEVDTFMFEGHDTTSVALCYVLLNLANEQEYQAKIYEEILSVLGTTQYPTQQQLGELRFLERFVKECLRLYPSVPFISRVTGKTIHTHSGYTIPKNSTVLIHIYDLHHNAEVWEDPERFDPDRFLPENVAKRHPFAYLPFSAGGRNCIGQKFAMLEIKAVLCGILRKFKLEAVDKREDIKFIADLVLRPTGEIRVKFSHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H2I4</accession>
    <name>A0A6P7H2I4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EF-hand domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114345288</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028151908.1">
        <property type="nucleotide sequence ID" value="XM_028296107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H2I4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050660830.1">
        <property type="protein sequence ID" value="XP_050516787.1"/>
        <property type="gene ID" value="LOC126891620"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H2I4"/>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000001">
        <property type="entry name" value="EF-hand domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000004">
        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="236"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="413"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028151908.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="88656" checksum="E7DF2BEFF7328363" modified="2020-12-02" version="1">MAGIPKLPGYTFTDPTHTKFHICQTFDVINGYKLPKNKFCGPGGRELQSNSVKCFTKQDVAMFDPSLMYGRTKTEQLPQFIPHYVLYSQKCLTFKAFFKQGVVESPNEFYRIRKVNIIYFLEDDTITVIEPRTKNSGIDQGRLIRRGKIPKNEKGVFWHWKDLNVGKDLVFNGIVYHTVDCDKFTREYMASQGLIMQDAEEMPVDPYTFNRELTVHSNFTKSKSVDDKMRRFLEYDGKVLKFKAVWDDRENEYGDLMKYDIMYFLSDDTVVVKEIHEKNDGRDPYPLLLRKMKLPKRYTDTPSTYPAIYLELSDAEITEYYQPKDFQVGETIFVLGRDMLLYDCDNFTRNYFKKALGIEQKPALDISEPNDKKPVRQIPPHDGLGSLEDSLQNTLSFLPKAPKKDVMRQLVNANKYLRYELVMDTVHPEDSIRKFVMSYSLADGTCKILEPPIRNSGILGGKYLSATLLKKPGSDPLNLDYYSPLDFYIGAIISVFNQRFKVVGADLYVYKYMQANESKFPCEVIENLRNYMFNKGYLKEDVDDQIKEDNESKRQWDIDTNTQHPDISNLEECYQRLGVGAGTDVAKEKETRDEIRRQYEESIVHKSSVLPYGIKPLKKDCRYPVVIGDVHKGTCRDVEQAGEYTSYTPKHIDTPEEIRAKYYSNILKAQQDICDDPKPIECVDPPPRAFDKACDEEENSKPKYIMVTKPDIPEQQCKGKTVTFAEDTDDRCARDRYDLCDLKREKTHCGCTDYQKDCIHSVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H2Q5</accession>
    <name>A0A6P7H2Q5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114349516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114349516</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155719.1">
        <property type="nucleotide sequence ID" value="XM_028299918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H2Q5"/>
    <dbReference type="FunCoup" id="A0A6P7H2Q5">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299918.2">
        <property type="protein sequence ID" value="XP_028155719.1"/>
        <property type="gene ID" value="LOC114349516"/>
    </dbReference>
    <dbReference type="GeneID" id="114349516"/>
    <dbReference type="KEGG" id="dvv:114349516"/>
    <dbReference type="InParanoid" id="A0A6P7H2Q5"/>
    <dbReference type="OrthoDB" id="6147983at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028155719.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="32089" checksum="BF24EBB21CDAA70B" modified="2020-12-02" version="1">MAVAWDDSLFNIKFVRVVERHPCIWNFNLQEYSKRDTTEKAWAEIAEEINETVSNCRERWRNIRTAFLRSLKTPPDRSAKNSKKRYYLSKYLQFLVPYTKRKKLFGNLEAQADFDYSDPMDDETNQVAELPEGLETDTKDNVRTQSPNPSISSRYVTEESDTEEMILTHSHLYKKKQFYQQTSSNSSKSTPDDDASRAFVEWVKQKENKNNAEENPNLLFLRSLLPDMMKMTEKQNRRFRQKVIGLMGEILEDEDIDRLACSTSSGTYATTSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H713</accession>
    <name>A0A6P7H713_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tenecin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114347886</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028154342.1">
        <property type="nucleotide sequence ID" value="XM_028298541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H713"/>
    <dbReference type="FunCoup" id="A0A6P7H713">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650657.1">
        <property type="protein sequence ID" value="XP_050506614.1"/>
        <property type="gene ID" value="LOC126884612"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H713"/>
    <dbReference type="OrthoDB" id="10038290at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
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        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028234634" evidence="9">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028154342.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10810" checksum="7A9594A37EFD744A" modified="2020-12-02" version="1">MKCVLFSIFLFAIVASINSSPIGQEQPKVDEPDVLIPEDYNPEQKEEHSRVKRFTCDVLSVEAKGVKLNDAACAIRCLTLGKAGGWCDRHKVCNCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9E1</accession>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028127932.2">
        <property type="nucleotide sequence ID" value="XM_028272131.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272131.2">
        <property type="protein sequence ID" value="XP_028127932.2"/>
        <property type="gene ID" value="LOC114324324"/>
    </dbReference>
    <dbReference type="GeneID" id="114324324"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF36">
        <property type="entry name" value="EG:BACR7A4.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
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        <location>
            <begin position="30"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127932.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="508" mass="55961" checksum="BC15D6C8108F07B0" modified="2025-10-08" version="1">MEVLENEDNEPATFEQAIRKTGFGKFNVTLMALTFFGICSPMFETTNMSYIFASAQCDLDLSLQDKGYLNSMVYAGMITSSFFWGFLLDILGRKKLMIFGYFIDATFLILSGFSQSFSMLLLCKFFGGFIICGPFAAMAAYLSEFHSSSYRARIQVVSGLFTGIAQIILPLLAWAIMPLPIKWSLFDGFIELHSWNIFLFVTGLCPFIAGTIFSFLSESPKFLMTSGKNEKALKVLQKVYSKNTGNSPESYPVKELVQEKEVIELSDVDPKPKVKIINGGMSNIGLLFKPNYISKFALITAIQVTFMASLNMLRLWTPQLFQVLEDYKVHNNGSTSDLCTMLTVLRPNPTMDSCSSNVAKPDAYFHSMIVASVGVVSYIFTGSVIHRIGKKNLLILAALLGALICFSLIYSRGVMITMILISLFTSCGNICTNVILSVIVDVFPTSLRALALSLVMALARIGVVLGNIFFPMLLEQGCHPPFLVVAGIIGVGGVLCFILPNTENTALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9U7</accession>
    <name>A0ABM5I9U7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128194.2">
        <property type="nucleotide sequence ID" value="XM_028272393.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272393.2">
        <property type="protein sequence ID" value="XP_028128194.2"/>
        <property type="gene ID" value="LOC114324532"/>
    </dbReference>
    <dbReference type="GeneID" id="114324532"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="128"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="244"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
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        </location>
    </feature>
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        <location>
            <begin position="299"/>
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        </location>
    </feature>
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            <begin position="330"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="428" mass="48429" checksum="F95DE99804E75104" modified="2025-10-08" version="1">MVELESNETIPCKFGYSYNNSMFASTIISEWDLICGRERLIDLSQATLMLGVLIGNILFGILADQYGRKPIIMLCITFQALFGIAASFAPYYWLFIFLRSLVAITNGGTMVTSFVMCMEAVEDRWRTVIPILYQIPFGFGNTIMAVVAYFVRDWRYLHFILSVWCTLFILYYWYIQESPRWLLATGRRTEAILTIKKIAEQYNIDQKEFQTYVTELSNINFLRVPKSPIGGIFSSGELKKRNTLLCLNWMFSGITFYAFSQYLGQIGTNIFLTVATSGLVALPGTIACIFLVGKYGRRWTIASSYLFTASCFLFISLTPKGYFDNDWLRVVLSGFGIIGISVSTPALYLFTGELYPTVLRNAGVGICLMFSRVGSMFAPFIITLEEKEAALPLIILTSITLLQALLVLLLQETKNLKLLDTVQDLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFL7</accession>
    <name>A0ABM5IFL7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
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            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131686.2">
        <property type="nucleotide sequence ID" value="XM_028275885.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275885.2">
        <property type="protein sequence ID" value="XP_028131686.2"/>
        <property type="gene ID" value="LOC114327305"/>
    </dbReference>
    <dbReference type="GeneID" id="114327305"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131686.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="250" mass="29078" checksum="C324F167333F4D9E" modified="2025-10-08" version="1">MHLLLIAGDLSLFLGTVYFVLSIFVEKSYNGISAKTQLLYMIVCTTRYFDDSSLFVWVINFFSSFAFFLSFRMKETYEKKYDSFWTESLLIPLLILAVFVNYDHSPFGILNAFSDYLESVALVPQLYMIWNKTKITKHIKIYLYYMYAYICLKMLYWFHVYYVYGTFNIISQVALAVEFIILSVSIVTLHCKSMMRTSYEVKVTKSQNIFLVNSGLLSLTTAKADEVPLITDEVTLVNEEAEKLTIIRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGA4</accession>
    <name>A0ABM5IGA4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
            <ecNumber evidence="22">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EC" id="3.6.4.12" evidence="22"/>
    <dbReference type="RefSeq" id="XP_028132105.2">
        <property type="nucleotide sequence ID" value="XM_028276304.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276304.2">
        <property type="protein sequence ID" value="XP_028132105.2"/>
        <property type="gene ID" value="LOC114327635"/>
    </dbReference>
    <dbReference type="GeneID" id="114327635"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048459">
        <property type="entry name" value="DNA2_Rift"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="11 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20 22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="24">
        <location>
            <begin position="219"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2 rift barrel" evidence="27">
        <location>
            <begin position="590"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="744"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="845"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="26">
        <location>
            <begin position="921"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132105.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1183" mass="133309" checksum="100C6CFAAB25FE1F" modified="2025-10-08" version="1">MNKPPRTKVKTPPKNNLKISQFFFKDRTNLKTNGTKEDNSEQSTNMALIDGAKSNKAGKTVNTNNDSMQSMGTLHNNKKRKSSEDEVDKECKKLCHEEEISCFKGHNVDESLDVTDCSILNQVPIDRLSSPEKLIKVKSPMKQKIEKENKTKQISLVKKEITQMDSFPDMCEVDFDDWEENTVIEPENFNLDLTQPCHCKITQIVTSGHTISLHLLSTKESKEAVCEVQGIWTYSNLSIGDTIYITCAKVNNTWVVNNDWGLIVFEPDILVSSTSVVGSLWCKRRNVLAERFRGFDSTNQYMILGTLIHSTLQHALKYNVSETEKLEGLVRKFMSKSRVVKNLYECDISADWINDEVVKYIPRIQEFMNVYVNKGNNQIQIKDNWKGRIDDIEDVEENIWCPELGIKGKIDVTVQVNNKPMPLELKTGKTSLSLEHRGQVMLYLMMMNKIGYNASSGLLLYIKEGVVKEISHTKKEERDLIYLRNELVYYLTQSVTEADNILIPPSLPEPINHKSCTNCPYSAICTVYAHVNNESLSSKPTLKSIQDEILQNLKQSHIDYFMKWTSLLLIEAESNKGAKDIKEIYLVPPSDREKKGRCISNLRISKVSDVIDELYFEHYFERMVPDSSGNFGTSGLLVGGYVVVSTDKRHAVAAGFVNDITATSISVTLERNLTLKFKNQTFYIDSYDSGMLQSFNLSSLALLLEPTPRAENLRKIIVDKESPTFRTTLPKVVGTTGKTILRRLNRVQQRAVLKAITANEYFLIKGMPGTGKTATIVALIQLLYELGKTVLITSHTNSAVDNVCLKLLEHGVKFIRLGSESKIHKDLHEYSEHSLTKNCSTASDYEAVYNSAQIIAVTCFASGHPVLTKRCLDICIVDESTQVLQPSVIRPLYACKTFILIGDPDQLPAVIKSSKARELGMSESLFERLYATDAATSLNINYRMNKTITALANHLTYNGELQVGNSSIENATISFPNKQVLTDSYSGDSWILKALDESLDSAVQFLDTGPVWNLEQDTSWKIHKSFSTEDTSSKVNIHEAAIIFKLVKALLKAGLPAKDIGVIASYRHQVEQLSTLLKSECIDINTVDQFQGKDKSVIIYSCGNSKNTDTFKVSKNDDILEDKRRLTVAITRAKHKLIIVGDVKTLMVYSTFKKLLSNFSNNVIKLCESRDFSWEQCLLLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKP7</accession>
    <name>A0ABM5IKP7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028279271.2"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="zf-C2H2"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="3090"/>
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    <feature type="domain" description="C2H2-type" evidence="11">
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            <begin position="3118"/>
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    <feature type="domain" description="C2H2-type" evidence="11">
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    <feature type="domain" description="C2H2-type" evidence="11">
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    <feature type="domain" description="C2H2-type" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="10">
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    <sequence length="3331" mass="376183" checksum="BE2DE6CD28D0DF3A" modified="2025-10-08" version="1">MKKRPQQCQRQVKSNTNIKSFINNLKENDLHFEDNQITQCVFLGVLRLKPVPSVFSSNTVPCLVVENKSKKPKNNNNTKEVNKNVSRKKDINKVISGRIGKKNTDIIRASVKKEPLKKGAIKLKLNMNKKDTTSKDSLESVRILPESLTKITSESVLTNRTITLNPITNVPTFNPVQNLFAKLKQQLDVSLNRPSCSSEVNKQTLFSDKSRTDIQLSSKKQKKGINKTKISSVGTFSDNSSHPNNSIYSKLTEDVFLINEDSTNEDCEVLLNTGPMPNFVLDTSKTDNDVILITDDNSDISSASKDLIVVDDVKCVRSSPRLNRNEQRSSPQKITATPETIINLDDGESNDKEKVAPKTKVEKPKKRRTLMPSAIPSIFFNTPRLLRSELGQKKGSFSEPKNVAKNSTTKIQKPENKLEKLPAKQRKESKLKNSTENIIYEVVKSTENIRLFADVVTNSQDDVVLVERSPPKVEPLILKLKKSTEKTADQNAIEDIRNKEKSQKMYTKNVTRNLFFPRLLRSDINQPKDSKQESTKKSTKTIEIGSQKTSQAKNEKYVPSASIGRISVKPVEQLIEKSPKQDEHRKNTTQKVTEKNIAVRDTVKKNEKSLPTSSKILGSQVQNASNIITIEDSDSTNLIDIFSQNNGKNKNIDNTSCELQNQSQLRSDDSQNKSNESVIEKIRKNVPKTSTIADNIEVIDNTSCELQNQRQLRSDDTQNKGNESIIEKIRKNVPKTSTIADNIEVIDNTSCELQNQRQLRSDDSQNKGNESIIEKIRKNVPKTSTIADNIEVIGNTSCELQNQRQLRSDDSQNKGNESIIEKIRKNVPKTSTIADNIEVIDVEFQSSTKTTPTKKQELKNASQEQSHVRQLRSDSPHKKANNAKPVAIDELNKTNGKSKTHSPKTGNDTVEDTVASSLKSKNKEDNVESISVDILSKVQGTPTVTKTGNTSTGTKTKNIAVVQPMSRQPTVELSQKKIAEKETINHIQNQNITSLEEITKGPTKHIVTDMSIHTEPESQPTHENTTALTTVAVGRFYSSDVTPQTVVSLQERRQLRSDDTVDKNTKPANLELNISRTDIDKLKTIEKATRKDSKTKTTSTKDKTKDTELEGGSVQQKTEAQKQISENSPTSKSTEQSDQKILRSSTVPIESKNASNQVEDSKVKAVGAQENLTNNKSIASDRNIKQDPNTNIKSKILESEDTSTNSKKTIKKYGRNILKCKTNSPTKQKKVITKKSIKKPSKSITFKTITKEVTDSDVSINKEISKSDSTSTSKRPLVKKIVHKFKKLASKKQLLKSTNLSTKKQSPKLKKKQTADSQITSQASLIVYSVRTPPKTASSASDSSQTITKKLKTPQKDTNNKILSDPQSNTIFDTSDNVKSKDCSSGVKIQKTNVPKSNPSKSEKKTETTVSLRNIPNTSTSNVSQEQSENLDQTKAHSAISSSKNDSTIQTKTKSSLVPLQKKDKMKQKINFKLYKKKLTRNLLRPIKKSAKVAPTADLKIISESNVILNSRRSISKLKAPEEAFKINQKEFNDSEVIKPTGPSESKVSTNESGDSPVHENGNTGNDIKNKLIKKQKALSIKKTIGSKIAANIKKTSIKLQNKKHNIEIKKRRGRPRRNPLEIKLDKTPTLGMNFEVSTQEVTLDKADNAVSETTGEVKRKAGRPKKQQGEAVLDKEQLNAATGEKGPNDTMYCHIPEPTESKKQKIATKQIKEEIIKDINEKSQLNEDYLNKTRSRSKKLLLDLTLDETQVTVVEIEEEKDDHETKSQQTNKTDSIKRKRGRQKKISLDNTSTKTLDTEMLLKQEIIDDENREELDKTYNSTNEPIEITVFDNSQVTEFGDENKIVNSSEIDIVKKKRGRPKRQTEITLDDIQVESTNVQKIVNKKPTRSSILAKTQDQAEDILSETENSNIQIQTLEISNVKNTKHAIAENIIVESNENEKIKRRSGRPKKVMVEGSKDETTVLEVQSCQGITDDKNDMSQSMESVDIKKNKRDSLKTNTNKSNRDQTAVILDDKLVCDNRVVTRQEQNIEQPKKKIGQVRKQIVTPLLVEDIVIKSDEKEENNLVQSGKSAEVKKKRGRPFKVSSELKLEEMRRKQIETPLLDEVIIIKSDEKEENKMGKSGKGAEVKKKRGRPFKVPTELKLEEMGRRQIETPVLDEVIVIKSDEQEENKLAQPDKNVEVKKKRGRSFKVPNELELDLTEAGQEQKTKKPKMTGREIKNLQMDLKLSEKTSDKNTANKKKPLQKTQEDLDVIMIVPEKRNKKQINTPLKTLRSSLNQVEKKRAVNIAQPTVEKVVALIHSEPRPKQQQDASEITLNHIEDTKESKTRVLRSQNVNEIDSTHVVKEDTKKSRLTKGHKIATKKGVSEKSINIIKSKTKLSKAFTGNKGATKKKNLKTDVMDKSKLKKMSNKSKQTVLKQIKTKLQNSKNKNVLKRSSRTKKSPSFNKKRSVDWDNNDIIERIIQEIRNTLFKEESNIIRKKIKQKKITLKTQKKKITKPVRIKREAFLAAKKKMMQTKEALKQKLRNAKNEVNTSGESESKENNPPKTEMEQLEDSKNECKTEEVLVESTQEDDVMITGETSFQSDVTNQTKKTDKHKKPELVNRTRRSYRSTLVSRHMASIVIGDDKEGENIDSKKNDITVFDFDESEPEVTPLRHKSVPKLNDFETPLFECRDKKTSNIELISSTPINSSATSNSQKSSILRSGRNPVPLTSVTENEIIEIPENVKQKTSKIELISSTLINSSATSNSQKSSILRSGRNPVPLTSVTENEVIGIPENVKQKTSNIELISSTPINSSATSNSQKSSILRSGRNPVPVTSVTENEIIEIPESSVSAVEQKPTLLEGDSSYSQEQLSKIKILKQDRLFSEILVYPDGEEEIVKDKPVSIEKENPVTDVKEHSSPEGGEMPCQELSSKRRKLLVPYIDDHGKPKKLWSVIETPRVPDTPPRPITPRQALSSPRRVRRSNSLDMVKPSTSAVKPAESDSPEEKKSPWKQPTIIEMFSKVWMKKEIPAKNLSEENNCKTEESIFQRPSTPDLNVTAPSPRRDRVDDEDSDTESRAEWIPEEYAEYKFKYSNSKLMQYKPIFKCKICLVVVPSYYKLLKHRKEHDVDKPYKCPQCSHNFSNVDDFSAHLRLHKGKHPYMCPKCDLGFWTKSAYEAHQPVHILKKAKQPVKKFRCDVCAKEFSKLCDVERHTRVHTGEKPCICNICNKRFQQAHNLSKHLLTHLHIKPFYCEICNKQFGRNDVLRRHLLTHSVDKPVKCSVCHRGFIRHSQLLQHMRRKHKRRPVEDVGESNADPNESESSETKDDGFDNQPSTSKSENESHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILA6</accession>
    <name>A0ABM5ILA6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028135518.2">
        <property type="nucleotide sequence ID" value="XM_028279717.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_028135518.2"/>
        <property type="gene ID" value="LOC114330373"/>
    </dbReference>
    <dbReference type="GeneID" id="114330373"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="201"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="460"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="731"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135518.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="783" mass="88647" checksum="960414B5EF94B545" modified="2025-10-08" version="1">MTTFKFTFDKNKKPPKGVLVAKKRKATSEDTIIPKKLAKNKVLNESDNTKIKKRTEKPPKVVSSSETNTANTQQGIGNKNLDIRQATNTLNNEKSSDFSPNTSQKFIKRKWKKDKLAAKKAAAEGNTPTHTDPQKKPQQYSLFNTGHKDVYVKGNAKGKSVVEKVFSADKKFSDLDIHKYIVSNLEKHHFTTLTNVQEKSIPAILQGQNVLVRSQTGSGKTLAYAVPVLQALQNINPRIQRTDGVQVIIVVPTRELALQSYELFKKINTFQWIVVGNLCGGENRNTEKTRLRKGVHILIATPGRLLDHMLHTNAFKTNNVRCLILDEADRLLDMGFKKDIVRMVEELDNAKTNAEYNPLALLKKKSFTDNEDDDVIETTETENTSQKMPLGDPSSKVRQTVLLSATLNKGIAELADFTMKDHVYIDALDEFTTQNPEMMVIPNTVQQKFIVTHVKHRLFTLSALILSQAKTNSKVFVFMGTSSMVDYHYELFTRYLIKMPRHRGQLANNQVMVLEEDEDSDDEEIVADVEIFKLHGNMDQSARKQVFTSFRAAKKGVLLCTDVVARGIDVPAADCIVQYNGPQSIEDYLHRVGRTGRAGKSGTSYIFLTHEEQDFVTEMEKHRVYLQKQDTERFLESLSDIMEEPDFEKAATALQKRFESALEKDKELHRAACSAYSSWSRFYNTYSNKMRPIFDFKKANLGHYVTSFALKETPTAVARIVKGQFAKKEAPRLNKKLANHEDDAPPPKAPKKKKIKSLSLTTSEFSSGLEPVKKKKKKTFDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INH2</accession>
    <name>A0ABM5INH2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137328.2">
        <property type="nucleotide sequence ID" value="XM_028281527.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281527.2">
        <property type="protein sequence ID" value="XP_028137328.2"/>
        <property type="gene ID" value="LOC114331849"/>
    </dbReference>
    <dbReference type="GeneID" id="114331849"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055308">
        <property type="entry name" value="TEX47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24787">
        <property type="entry name" value="TEX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137328.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="331" mass="38521" checksum="6D51C60351452416" modified="2025-10-08" version="1">MLKSVNITYPNRRQTAKDVKVIGLQEPVRRTMYDIVKDNFKTIQRTDFLMRIVYIGEHTFPIADNTLNDFFLETVTMANDNYQCSEKITGLFVRYAKHFIHLLEGDEIAIHLHLKYLFRSENHIQKLKNMRLLVQINHVHSRLLCDWQTYSSNPAKLLENIDAENIKEETGRQIFACVKKMYDLIEKMSTRDSVIVTARSELGSIQLDTLSLRDTSSLYLRPSLIGGSLNYVDFYRKGLPEIERLDFIIKSPFPIDLHAFKDIFGVVPQRDIYKDKVWPVPADFIPYDIFDKLYDIRLDFPKSGAGGVQESEVEEEHLTESDISTNEEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRU0</accession>
    <name>A0ABM5IRU0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor Adf-1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028140030.2">
        <property type="nucleotide sequence ID" value="XM_028284229.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284229.2">
        <property type="protein sequence ID" value="XP_028140030.2"/>
        <property type="gene ID" value="LOC114334191"/>
    </dbReference>
    <dbReference type="GeneID" id="114334191"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33818" checksum="3C810EDDE8E2E296" modified="2025-10-08" version="1">MDMEFTIDVKQLIEAVQQRPCIWDIDDNDYTDKEIKKRSWEEIVNIFIPKKDATLTEKREFGLQLHRRWKSLRDSFARELRTQKKIKSQGGQRKRPVYVYFNRLSFLEKSVVTQPFTNSSKTDDDQNLETTSPNGRSPPQKSTKPASKRKKLDPVPAGEKLVIAAENNVQTRQEREGDVENDSDRLFLLSLVDPLKRIPQYARFGVKRKLMDCLDRELQFYGLAIATDALHYHSSATDSSNNPLSPVDLLSPPALNETEMEFTLEDEQLNFKVESLSPSYSNSSANTDPLSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IS63</accession>
    <name>A0ABM5IS63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140347.2">
        <property type="nucleotide sequence ID" value="XM_028284546.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284546.2">
        <property type="protein sequence ID" value="XP_028140347.2"/>
        <property type="gene ID" value="LOC114334499"/>
    </dbReference>
    <dbReference type="GeneID" id="114334499"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="34"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140347.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="261" mass="29888" checksum="6E1B8F2B4892A448" modified="2025-10-08" version="1">MGRPTNSSRSKGSQRSLSQLTQESSQRNGNGTDIEDHVNNLVRYFINRAGEHVSFKRTELRKNVLVNVGTQFQEIMNKATKILEEVYGYKILIADSSQNSAKEYLITNVLPYKPDPTEYIPPNGYPEDANKVFTLLVLSHVFMSNNSVSDNSLYSFLETFGIDVQRRHEIFGSIKDCLNVLKNKKYINMETEQLSKKVTFSWGSRAEKEISKLEVLKFVCKMYKTTTPTAWIKQYQSVQEQMQANEINNVDEDGLTQNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUI2</accession>
    <name>A0ABM5IUI2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142492.2">
        <property type="nucleotide sequence ID" value="XM_028286691.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286691.2">
        <property type="protein sequence ID" value="XP_028142492.2"/>
        <property type="gene ID" value="LOC114336335"/>
    </dbReference>
    <dbReference type="GeneID" id="114336335"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047355127" description="Invertebrate defensins family profile domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142492.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="87" mass="9628" checksum="D953FA869CF0547D" modified="2025-10-08" version="1">MKNIIVSFFVICLIASVFASPARISFKDVDQHVKNQQGHGRFKRFSCDVLSIEAKGVALNDSPCALHCLSLGKRGGWCNDQKVCNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUU4</accession>
    <name>A0ABM5IUU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centrosomal protein of 97 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142854.2">
        <property type="nucleotide sequence ID" value="XM_028287053.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287053.2">
        <property type="protein sequence ID" value="XP_028142854.2"/>
        <property type="gene ID" value="LOC114336693"/>
    </dbReference>
    <dbReference type="GeneID" id="114336693"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="708"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142854.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="90281" checksum="0F7F005E6840F68B" modified="2025-10-08" version="1">MEGTQEILDLSNKKLKKLNKPTATESQVTALILDDNELQRLDNIDSFTKLQKLSATRNQLLRMYGVCRLHFLHTLNLSYNGILTIEGLKELTSLKRLCLAGNSIKTIEHLHTNVNLEHLDLSENSITHITDLSFLKNLKELFLHKNKINHLSQCDRFLPTSLTVLTLANNNIQDLNEVSRLVNLVNLTKISMVNNPCVNMTGNNVGFDYRPFIVNWCLNVNVIDDYVVDAIESLRAEWLYSQGRGRHYRVGDQKELVQYLATVCPLTGETLETEEDRKLRLILSKAQHHQQQLREQSSNNVTPNPSPMTRKKLMGANRQSPRFSGGSKGSNRNKSPDRMTASCYSPFNDSNNSNIMTQSLDPLLLRMNVVPRPVSNDSNSIIAEKCLDSEPINSPLQALSKNVPVPESLMSPDYHPSSLMGTKNAQNISLQPNNVARVHSAQTTHTSKSPKFNRAIPNRARTDNLRKVGSPSPVRQNRMNTKTPTSNKQESNKKASILMNRSASSDEESEICDSKLQTIQMKAEERRLQKEEVNSNCSSEDKVEQAAVCIQRIWRGYYTRNKNKEVQEMFKELQNQRANQYIQKLATDMETTKAALESERKIQMLQTEAISALWKKISNIQPTADGEGMSNGNLNMTNLSLNNSEVVKELAQTCTMLQSQIQQLQTSMQDIVKVMTAFSQTAGINQQLKDGIATQTEIIAVHTPQGDAAKSFPFQKHSNQSRPSSLPLPVHQRKKEVHQNNGNSNNSSTVPSELTQYARTLVDGVIRTVSESNADSLGSNTEITVTDTEKIGEYIDDNREQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IVS1</accession>
    <name>A0ABM5IVS1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144153.2">
        <property type="nucleotide sequence ID" value="XM_028288352.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288352.2">
        <property type="protein sequence ID" value="XP_028144153.2"/>
        <property type="gene ID" value="LOC114337817"/>
    </dbReference>
    <dbReference type="GeneID" id="114337817"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047276291" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144153.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="26427" checksum="AA3AEC1F0972B4CE" modified="2025-10-08" version="1">MFKIVWNFVCLLTTVYCIGVDVETHNPLGSVQFPDDPDPVDSYINCQRCQGGPLTHCGQVIGRGVEEGFVCKTNLCYEAYIGYQNGAMPIVQRRCWQPNENETAPDYCTWFETSEQKKKTNAIMIACKHCTEDLCNLDKEFWLDPRYIKYPNYDHDKHHHLNHYHINYDHERYDDINYYHTKYDHDRHDDYNHYLTHYDNVKHDYHRFPYYTHQEYNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYG2</accession>
    <name>A0ABM5IYG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028149401.2">
        <property type="nucleotide sequence ID" value="XM_028293600.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028149404.2">
        <property type="nucleotide sequence ID" value="XM_028293603.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293600.2">
        <property type="protein sequence ID" value="XP_028149401.2"/>
        <property type="gene ID" value="LOC114342798"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293603.2">
        <property type="protein sequence ID" value="XP_028149404.2"/>
        <property type="gene ID" value="LOC114342798"/>
    </dbReference>
    <dbReference type="GeneID" id="114342798"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="529" mass="62325" checksum="F835F637BF203922" modified="2025-10-08" version="1">MACPYLYRTRFYIAYVAKSFLVCIMTIIIFFFVRHILYSRGILLKIKMSKHHAESQIKAFSSVLETDIDAYSDEKALSDEQLKLVIEKILPSLPKIKKDWKSDAKRGYNQTCANFFYRFVLPLNIEYRNSYWQSQKTSNGTFLLYNAYLDTRSENTLGPTVRIVGMIDIHKINSTTYCHLWFNGTNNPVIVKTFEHRSIWWFGKPQKGYFIPYLISCVLPKKFSKRIPESISLVERECDNATNRLRVLYDNPGKKEDFAVCVKGLTYPNDISSRLSEWIEMLNATGVNKIFFYELYTHPNIRKILNYYEKIGKIQVTSLTLPAGASNVPFLQHFYLEKQGIRKRLNEIVPYNDCFYRNMYRYKYIIVIDTDEVIVPMKDDNLKALMHRVKMKLIAKGKIERGSAYTVTNVHFVNRLTQDKTIPKHMYMLRHTYREKKMHTKEFLKSFVNTEKVLTLFNHYPLGCLKPGPCLKYHIDSEDAHLQHYRENCKIKCKGEQQSIVTDESIWKYRDILIKRVKDTLNNTGLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZ45</accession>
    <name>A0ABM5IZ45_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028151092.2">
        <property type="nucleotide sequence ID" value="XM_028295291.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295291.2">
        <property type="protein sequence ID" value="XP_028151092.2"/>
        <property type="gene ID" value="LOC114344460"/>
    </dbReference>
    <dbReference type="GeneID" id="114344460"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151092.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="693" mass="78117" checksum="957A879F4C034E28" modified="2025-10-08" version="1">MSHLSRVVILLDMDCFYCQVEEKLNPALEGKPIAVVQYNQWRGGGIIAVNYPARDRGVTRHMRGQEAQKKCPEIILAKVPQVRGKADISKYRDAGKRVADVLQTFEALLERASVDEAYLDVTESVLKKIQNGIDDLTIDKLKNTFVVGCDTKDFLHNLQNSTEFSESNLKLCLGGVIAEEIRAEVLKQTGYKCSAGIAHNKILAKLACGLHKPNKQTILPHDAVPDYFKTVPINKLTGLGGKFGDEVINELGISKMAELASFSEKQLVDKFGMKSGSWLYSLARGIDMEPVVSKLISKSIGCCKRFPGRTSLVTHSAIQHWTNELATEISERLEKDQEENNRKAKQMIVSFAQEVNKRDVSSSRTHPLKSYEQSRIAQDSLEVIKKHCQRPDGSYNVTFLGVSVSNFQDMKKSGLDITSFFKKSTNTSIAPVKMEEKSPNNQTNENSSEIPLPETDVDSITDFNEDVENVSIYSASTEDLEEDPKSYIYFEDIYPEFVSSQPLANYCEQNNVPTEVSEVVDQTKELEESRMKSSKSFFSKYFESPSKEETVDREKLNISNESMDYCCDSVSRKNQNIIEESIEILEQSTATQPNTISVEYQQNQSLKRKSSELTISEYFGKSEEPDENYCIECKKNIPLKDFLDHGDYHVAKRLQEELNKPSSTNNTSAKNSIIKVKGKKPVNGNITKFFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J033</accession>
    <name>A0ABM5J033_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028155109.2">
        <property type="nucleotide sequence ID" value="XM_028299308.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299308.2">
        <property type="protein sequence ID" value="XP_028155109.2"/>
        <property type="gene ID" value="LOC114348826"/>
    </dbReference>
    <dbReference type="GeneID" id="114348826"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155109.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="332" mass="37520" checksum="5F1E1BCAF89EE0BE" modified="2025-10-08" version="1">MLQRISSFVRLGRIGKSLCDNSHILFSLSTSPRLQVLRKMSYSIVERGSPFSPDYRVYIENQNGPISPLHDIPLLVDGNPKVFNMVVEVPRWTNAKMEITMKEILNPIKQDIKKGKPRFVSNCFPHHGYIWNYGALPQTWENPEHLDDGTGCKGDNDPIDVIEIGYRVAKRGEILNVKILGTLALIDEGETDWKLIAIDVNDPLADQINDIPDVEKHFPGLLKASVEWFKIYKIPDGKPENQFAFNGEAKPAAFALKIVDEVHKFWKGLVAKEVDAKGISCVNTTLEGNSFNISYNDAKEVIEKTPEYGPAQPTDPIVHKIYFVERSYQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH29</accession>
    <name>A0ABM5JH29_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497238.1">
        <property type="nucleotide sequence ID" value="XM_050641281.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641281.1">
        <property type="protein sequence ID" value="XP_050497238.1"/>
        <property type="gene ID" value="LOC126878524"/>
    </dbReference>
    <dbReference type="GeneID" id="126878524"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="455" mass="51808" checksum="F1828290102A0922" modified="2025-10-08" version="1">MLAPRHKNNINLIERELCALKNKFQNDQIMLTEVNNLSSRIENISRRKVEYKDTDFGPFLTMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMVLNSTEILEKGFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNVKIISARRLNRRVLDSNGTVTYIPTGTVQLLFDVRTPPKEIIIYSNLVTVDPYIPPVQQCFKCLRFGHSQRQCRGKARCPKCSDEHTVQSCTVSVPKCLYCDLDHLATNKICKEFERQKKINEVMVFQDLTFFEAAKLFPPIKEKPENSRMFQRRSRDFPSLLSSSPRAFTQALQKSPSSTPHFQSQSHVVPVKRKNKVILKDISYDKEAHKALLNEDLSRNLPRLPILNKLNDSQKYTGSQGPSFALSLTRNRVHSQDSVFSKNVDLTSDNNMEFAGFDESHNTSNFSKSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHD6</accession>
    <name>A0ABM5JHD6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497352.1">
        <property type="nucleotide sequence ID" value="XM_050641395.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641395.1">
        <property type="protein sequence ID" value="XP_050497352.1"/>
        <property type="gene ID" value="LOC114340507"/>
    </dbReference>
    <dbReference type="GeneID" id="114340507"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="853"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="11">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="10">
        <location>
            <begin position="343"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="924" mass="105279" checksum="318EE0C8EFF11249" modified="2025-10-08" version="1">MSVRRNMLCTTPSEKVQSLLDQEENTQNGQFRLFSEIQELNIERGEMIWRETARYIKFEELVEDGGSRWSKPHVASFLLHSAFELRRLLLSGIVMFDMPVLSLYRVIDLVLVDLGENYNLSVDEKFKVKKVLLARHQHQHQRDRERRKKAFIKVNPFSSSQTSTSSLEDIPDAKQNLKFMKKIPEGTEASNILVGGVESLEKTIVAFVRLSEAVMLDELTEVPVKSRFIFILLGPLGPKSAENGFHEIGRAMAALMSDEVFCEVAYHARDKSHIIAGIDEFLNAIIAIPPSEWDPAVRIEPPASVPSQDRRKRPPEKFIIAVDGDTEEQRLREYSGLVRTGVLFGGLVNDVKRKVPFYVSDFKDAFALQTIASWIFLYFACLSPIITFGGLLSEATGKSMAAIESLLSGLICGVIYGFFSGQPLSILGSTGPVLIFETIIYDFCEAMTWDYLSFRFWIGTWTSIILLTLVSIDASAFVSYITRFTDENFAILVTLIYIYKAFENVWAIKSKFPINLDINSMNITNCTSTGKNKTISQFLIMTNSSITDNATMQFLNGSSTEGCLEPPHHPGIFFMSLFLFLGTFFISIQLKYFKNARFFSSRVRQYLSDFSITIAICSMALLDFYVGIPTPKLEIPHELKPTLPDRGWIIFPFNGNPLYTVFVAIFPALLGTILIFMDQQITAVIVNRKEHNFRKGCGYHLDLFVLAILIQICSIMGLPWFVAATVLSITHVNSLKRETECTAPGDKPQFLGVREQRVTHILIFLSIGLSIFLSPVLEHLPMPVLYGVFLYMGVTSLKGLQFFDRICLLFTPMKYQPDYIYLRQVPIRKVHIFTIIQLTCLIGMWLIKSFRQTSIFFPLMLVVMIAIRKSLDFVFTKKELRALDDLWPQNNQIQRIEESRCWMSKYILGPKLIPRREHLDTIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHU4</accession>
    <name>A0ABM5JHU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497511.1">
        <property type="nucleotide sequence ID" value="XM_050641554.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641554.1">
        <property type="protein sequence ID" value="XP_050497511.1"/>
        <property type="gene ID" value="LOC126878693"/>
    </dbReference>
    <dbReference type="GeneID" id="126878693"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="334" mass="39026" checksum="2578CBD6FF015290" modified="2025-10-08" version="1">MSQTKFYELLRMLPFSKKYTPFREPVSWEERLALTLKFIGHVNSFTTLSFSYRLGYTTVRTIVYETLECIWENLQPVVLPNPSKEHWEKIERDFHEMWNFPNCCGALDGKHVVIEKPPRSGSLYFNYKHQHSIVLLALVDATYRFVTVDVGAYGRNSDGGIFNSSSLGKKLYANELNFPPSKPLPNTNTVLPFVIVADAAFPLKDNIMRPYPSNEIANNEAYKVYDYRHSRARRVVENAFGLLTKKFKWYYTKYNILPRNIDKIILATVVLHNFLRNDKCSWQPEEFCFLRDLSHIGGRTPFSAERIREAFTEYFVSPNGSVPWQLERVYDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKJ5</accession>
    <name>A0ABM5JKJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="RefSeq" id="XP_050498454.1">
        <property type="nucleotide sequence ID" value="XM_050642497.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498455.1">
        <property type="nucleotide sequence ID" value="XM_050642498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498456.1">
        <property type="nucleotide sequence ID" value="XM_050642499.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498457.1">
        <property type="nucleotide sequence ID" value="XM_050642500.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642497.1">
        <property type="protein sequence ID" value="XP_050498454.1"/>
        <property type="gene ID" value="LOC126879472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642498.1">
        <property type="protein sequence ID" value="XP_050498455.1"/>
        <property type="gene ID" value="LOC126879472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642499.1">
        <property type="protein sequence ID" value="XP_050498456.1"/>
        <property type="gene ID" value="LOC126879472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642500.1">
        <property type="protein sequence ID" value="XP_050498457.1"/>
        <property type="gene ID" value="LOC126879472"/>
    </dbReference>
    <dbReference type="GeneID" id="126879472"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="402"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="721"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131739" checksum="C9D6E072DB22D488" modified="2025-10-08" version="1">MPGLVVFRRRWSVGSDDLVVPGVFLFTVHLIWTIILSAVLFLLKYDRSVQCIFLMWGFIVGYLALLILSMVTELCICVVAMRGSILDTGKRASMQYILYLRLTVMIIEAAWLSAGIAWLVKYYLDCPADNAKEFVIVMVIFNWCILFSVIITVWCTYDSAGRSWVKMKQYQRSMRESESKFQYKRSGSTRNWRQRKVLRAYQDSWHNRCRFLFCCSTSNDRNRNSFADIARLLSDFFRDLDVVPSDVIVGLVLLRKFQKIEQKAIVEQRKNETYEFLSGVAVTPTTQFLSLHEDGSDLELFQTVIHYAHYAVRAYGWPVFIVTNTLGLCSLCAGLRCCCCAPCRKHSSSPQIVDDNCCQCNFAALDKLSEIGDIEIIYATYHVDIGQTPFFVALDYDRKKVVISIRGTLSMKDILTDLNAEGETLPLDPPREDWLGHKGMVLAAQYILDKLDEEQLVERAWEHNPERGTADFELVIVGHSLGAGTASILGILLRQRHPTLQCFCYSPPGGSLSTPAVDYTKQFTVSVVVGKDVVPRIGLYQMETLRTDLINAIKRSVDPKWKTISCSVLCCGCSQPTSAVELSTGEKDVTEYMRSKENARCLGLHPSDSTIALTSHQPLFPPGRVIHIVRHHPTSGQQTLNKKDPVYQALWARNTDFDEVLISPVMVQDHMPDKVLEALNKVVTSKGPKKPQRSASTSEPSSNYYSATSIPNCLLETSFTSLQSPSSNSSITNGYYSTRSQPSPLSSTPNTLCPSIPVMKLQPSREEPKTISRSLSLSLRSITTPKMDLIHDDWLGLAPLASPESVSDLSSISSRASLVTTSNVIVEINCTPKILRRTPKIIGSLSSCADDIRNIRNFQKAKTFKTRLLINNNIESSSSSNLSYESASSSNKCCQETSTLGSSCGINQCGEIDCEPSDAEFQSAEDILDNVLASAGCKEFFNSDSNILETHFDFLQDLPSESTALGYFGTSPTFSTVMSPSTPIAMDQDMISNLAIDLNLDEDHRAIRFQKPPSQPSSSVDSGSVCRTPSDITKNVTFNPEVITVDAIMCERRYSPPRWRQLFRGKHSRQRTDVTSPVIEINPSAVPIKTILSVKRRSHEETDPSLCTPSTSAAVKNVVSYKQNEEGDHCFSRTEQLPLLSGLNNSGSERKPSPCYVRRKKYVYPSDIVMMSQQPNESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM61</accession>
    <name>A0ABM5JM61_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membralin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499026.1">
        <property type="nucleotide sequence ID" value="XM_050643069.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643069.1">
        <property type="protein sequence ID" value="XP_050499026.1"/>
        <property type="gene ID" value="LOC114332134"/>
    </dbReference>
    <dbReference type="GeneID" id="114332134"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71980" checksum="4FB15EAB71C815AF" modified="2025-10-08" version="1">MSGNAPPVAQPNPENHVGALINTNRIRNNNNQNPLFNVRDRLFHTLFYRAALAYARTFPRPLRRFLEFLTLVKAIAAFFVLVYIHITFSRTPSTCLMHVKDNWPRDGILRVEIVRNVGKDYNIEQSYAKEEKLKQQGKVEDLGNVIGLLARDGFINIEPTAVEDNHKETEPLESSVEVGNINYKKVDEDAGDKIVDNSLLNVSKISPTRWDDYQLLTDRPRVTTEKYEFGDILPVDENITSKVDISSNVVEDDKSGGYQEHEYIVEFSLEYGFLRLSPATRARLKIPVEIVTLDPAKDQCFGDAFSRLLLDEFLGYDDLLLASIKTLAENEDNKGYLRNVVSGEHYRFVSMWMARTSYFAAFFIMIVFTVSVSMLLRYSHHQIFVFIVDLLQMLEFNVTVTFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWMADQYDAICCHTSITKRHWLRFFYLYHFSFYAYHYRFNGQYSSLALVTSWLFIQHSMVYFFHHYELPVILQQAHFQQFLMRNSPPQLRTLTVATPQMPLRITDFIPAIRSSATTQTSTTTLPTASSTATNTVPTTTISVGTIAQPLSSTQSSQTISTAVETTESQTLEGITTQPASIQTQDYESIPPNGGSDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ69</accession>
    <name>A0ABM5JQ69_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500088.1">
        <property type="nucleotide sequence ID" value="XM_050644131.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644131.1">
        <property type="protein sequence ID" value="XP_050500088.1"/>
        <property type="gene ID" value="LOC126880335"/>
    </dbReference>
    <dbReference type="GeneID" id="126880335"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF33">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="275" mass="31189" checksum="37341E70172C463D" modified="2025-10-08" version="1">MHERSSEHRKHYLEWKSLQISLKGHGVDSNLQQIINCEATRWKAILQRILDTTIFLSSRGLAFQGENTQIGDVHNGNFLGVLELIGKYDEVTREHLAKVKENQLNKKSMIGQAHYLSWYSQNEFISLCGKKLLNTILHQREESVFYGIIADATPDISHQEQNVLILRYVFQNEEKNTFEVCERFIEFLNFSGKTGEVITDEILSALDNIGVPLSDCRAQGYDNGSNMRGHTKGVQSRILEKNQSAIFSPCGAHSLNRVGVNAAMMVAMLLTFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRN1</accession>
    <name>A0ABM5JRN1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho GTPase-activating protein 100F</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500594.1">
        <property type="nucleotide sequence ID" value="XM_050644637.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644637.1">
        <property type="protein sequence ID" value="XP_050500594.1"/>
        <property type="gene ID" value="LOC126880626"/>
    </dbReference>
    <dbReference type="GeneID" id="126880626"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052118">
        <property type="entry name" value="Rho-GAP_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057459">
        <property type="entry name" value="SYDE1/2_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25336">
        <property type="entry name" value="C2_SYDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="751"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="930"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1514"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1549"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1567" mass="170252" checksum="FCD569B3BFED6286" modified="2025-10-08" version="1">MTVRDIAMAACKEKSSVLRILRLFRDAGSSSPKRKGNDNGREALDLTASPLRAPAAAPNSRTSHPPPMVIQGDFRKVSGISSEIFKQIETVENDHDASTAAALDHVERRGEMIVRILEARHLSRTANEAVKRFTAMQDAKHTVQFVEIVKRPGQTLGLYIREGNGIDRNDGVFISRIALESAVYNSGCLKVGDEILAVNLVDVTRMSLDDVVIIMSIPRRLVLATRQRKASKGGQSSPSVQPRAEHKPPPVVVIKRELREDETDDGDLDHRETIRQRHTGDGREMSESRSRLGLGLSSLDSRHSGQQSVDSNGLDLYYNSRPPDANWGYQPPPPVITEQPKSSMQHFQPYERNYPNTLESLAEKVHSFGMSRRMSAGGQPLGTRISSQQSPSSHYYVQHAGTGSRRIMPRSGSDQHLPQTEYSDYTSITQAGRHSLLRSSLKSGSTLSRYNQRFVDQAAVAAQIAQAKYGTSGSQYSTAGTMRRTRGSLDYSSDTEATSGSRAGYYYYGRSQGAAGGIPHSTIPTLGRQNSLTTQDITTKFNSLPRDTRAATRLAMNKRFGDRSVSLIQDEADGALSAPEMPSSIRRDRDEYRQWLSRTPSTSAIYEQIRASRDVLNQQRAARFTYSAENIHDALKNMESGLYSGYGRPGATSTLDRHFTRSQTANIPARSLSTQHITSSSALSSSRSPSMRRMRQLLDLDSVRTGAPSPVPTPSGTLPRGQRQLDINPAEFLKYKLDKPAGLVGGTSITGLSQLAAGPGGLPSDEPISGMLWVHLLAGRGLRPSTGTSAATTPVTPSGGAPAAITGPTAVRDLYCVLECDRVHKARTVVRTGDLVFDWDESFELDLVNNRELDLLIYSWDPQYRHKLCYKGSVYLPTLLKSGPIHQLALKIEPRGTLYLRLRHTDSQNLYRRRPLSTLTLSRTTPLFGVDLETVVNRESKTGGVPGGVATGLVASSQHNIPIIIRRCVEEVERRGLDIIGLYRLCGSATKKRILREAFERNSRSVDLSPDNVPDINVITGVLKDYLRELPEPLFTKCLYQMMVDALGVCLPDDPEGNAKLMFSILDCLPRINRATLIFLMDHLALVVSASDRNKMSAQNLATALAPPLMLQTSDSITPTTATKSHDIDYQQPISVLKYLLQIWPTPKHHHSGRRGRPSGPRGDSRSACPPQGAVAVALQSSVGPAGAREQSRLSQAPFPPPPRSAVSGPRGPQPQVPLHQILGPSSVSKGPYRPLSPRVGPQATSSAGVLRPRQVIVSSPGSPSSSSDSQSGSESVKHCLPSRVSSPVIRASPSSQTILRSSPSVTINSPGLRHSPSITSAVSGSSSGPRNSPSISSLSRASPSILGQVSRSSSPAMQASSAGLNVTLGTTTPSFTSTFTNLQSSMAMTSTGGYGWNYAQASTYTQPTTYASTNPFLTGSYMSYTPGDSTFSEKFNTIGPSKEVKSFFDSYTSDTNKYSTLNTKSTSYDSEYLYSSPDVKTNGVSSRYLDKSYLNSTYSTDLNKYSPAKNAMYDTSPNVTQSTSSSTSGLLNVEETPTPTSSIETEDSNTREVGEKDVEGDGEQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSG0</accession>
    <name>A0ABM5JSG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500870.1">
        <property type="nucleotide sequence ID" value="XM_050644913.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644913.1">
        <property type="protein sequence ID" value="XP_050500870.1"/>
        <property type="gene ID" value="LOC126880845"/>
    </dbReference>
    <dbReference type="GeneID" id="126880845"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22200" checksum="65635F99963E2036" modified="2025-10-08" version="1">MINGFRNKLNVFKRALEKNNLTRFPSCLQIAEEFNGEENIEFSSCISQIEQVIDEFNTRFEEIESLKSSVLLYNNPLGATIDDQPPNLQLELCDLQADMFLITRQEKGPEFFKLLSKEKFTNLRDFGLKMTSMFGSRYTCENAFSSMKYIKNKNRSNLTDSSLRHLMRLSTTELEVDISSLVDEADRPQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSW7</accession>
    <name>A0ABM5JSW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501036.1">
        <property type="nucleotide sequence ID" value="XM_050645079.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645079.1">
        <property type="protein sequence ID" value="XP_050501036.1"/>
        <property type="gene ID" value="LOC126881064"/>
    </dbReference>
    <dbReference type="GeneID" id="126881064"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="317" mass="37179" checksum="15A02D012D2BF9FD" modified="2025-10-08" version="1">MADMTNLYGTQKNIARFPPTNLDEIKTFIGVHIVMGNLQFPRVCMYWHRSMGIPLVKDSLSLSRFYKLRQTIYLVDILSRNEDNKDRLWKVRCLYESVRKRCQQLPLETNLCVDEQIVPFKGQINIKQYMKNKPNKWGIKIYILAGQSGLIYDFLIYQGSTTPINPIYVKYGSAAAVVMQLSERISEKNHGLFFDNFFSTYKLIQYLDSIYKVALKPIWTYGVQLWGTAANSNIEILERFQSKVLRTITNAPWFIPNREIRDDLQVATVKETVSEYSSRYLVKLENHPNNLALNLLDNSEQTRRLRRHKPLELPHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUW5</accession>
    <name>A0ABM5JUW5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501730.1">
        <property type="nucleotide sequence ID" value="XM_050645773.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645773.1">
        <property type="protein sequence ID" value="XP_050501730.1"/>
        <property type="gene ID" value="LOC126881488"/>
    </dbReference>
    <dbReference type="GeneID" id="126881488"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38937" checksum="769C7C7D433BDA71" modified="2025-10-08" version="1">MTEKTWTVVQFIDDATVEAVPSMWIQGNRCHWPSTLPIDKLNNAIRKNDPLNTCWPSHTVKTFRNATFDDYMTARKKAKVAEERSDLSSTDEHHKRKRIQKIVSSSDESLEENSTIIGPAPKFTIRNIKVTQEITKDALGSTRGSTQTETYPVNEQLLTSACQNIQCVEKDKMLKTLIQQGHILRGLVTETLAEVRVFRKEFKQYHTTTNETDTGHKFFQSYSMPIKNEEEFSIIEEALENKETLLNTITEVSKLGGATVYDFVRRAMILILTNEFANEYSWLGRKGKKPFHTTNIAKMVIRAAEVAGLTKSQKETEVSIQTWLRRASDRRNSGKIIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JV42</accession>
    <name>A0ABM5JV42_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    <sequence length="612" mass="71411" checksum="74FF344C091C662E" modified="2025-10-08" version="1">MELSDDSIKRNQNVLICENDGDPQYLNVQVKSELEECLSESSYTQEALSNSYCVDDIKIEERVLQYEIGSPFPVINQEVKTEIKKELDEQNLEVNHECETQYTKELDSEDVKLQIEALTKIHHEKHCRSMKTSKLLSNKCKQRLRQNEIKTKSKRSLVTHTGEKRYQCDICCKKFSNSSNLKKHLRVHTGETNKCEICSKQFSQDGNLKRHLMLHNGEMPYKCGICSKQFREAGNLKSHLRIHTGEKPYKCDICSKQFSRNGDLKRHLRVHTGEMPYKCEICSKQFSEAGTLKRHWRIHTGEMPYKCEVCSKQFSHAGSLKSHLRVHTGEMPYKCEVCSKEFSEAGTLKRHWRIHTGEMPYKSEVCSKQFSQDGNLKRHLMLHNGEIPYKCGICSKQFREAGNLKSHLRIHTGEMPYKCDICSKQFSRNGHLKRHLRVHTGEMPYKCEICSKLFSEAGTLKRHWRIHTGEMPYKCEVCSKQFSHAGSLKSHLRVHTGEMPYKCEVCSKQFSHAGSLKTHLRIHTGEMPYKCEVCCKQFSHAASLKTHLRIHTGEKPFKCEICFKQFSRNGNLKRHLRIHTGEKSYKCEICFKQFNRDRHLKKHLRRHTDEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
    </reference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="454" mass="52980" checksum="92EAC8038395D941" modified="2025-10-08" version="1">MRIWKAWLKKNGENIQKNFITTNAYTCIEINAHGIILVIEKLRQNGISEAFLPWLYSSQPCEKVFRETRSMSSTFSTMINYTLLDVLRRLKRIQAMHEISTDLGPNFRFPRQENKRLGNNSSVFKVTEFPSTDEMINIIKKAQEDALSDAKKIGMEMNRDCCIEINLPTCDNPEEQEEVQGSIIITDTISKEHEPDLEPDFSNEDREFLEYTSTFNNYDSLHLRDYTGQKKAQKSCLSVTLKDKKTRIIKKSTLIWFFQEKQGRLSTDRLLRVKGMTVKNTHKGLSKKKQFRKKPGQGLQPAGNIKKRKMFRQPHERAHKDSTSESRSESDEISLESETLSEDFSDLEDCHNESTKMPVIQLESYYAVFYDTQWYLGRVINSYSSEKFKVKFLQQDLDTFKWPKKDDIQDVHKEFIFYGPVSLSGTEPFSLKRNDLIAIKQKYKTIKSIKSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0H9</accession>
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        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF05699"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503689.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24128" checksum="A865B8C9E36F52B9" modified="2025-10-08" version="1">MLNLNLQGRNQTVSDLIGMINGFRNKLNVFKRALEKNNLTHFPSCLQIAEEFNNEENIEFSSCILQIEQVIDEFNTRFEEIESLKSSVLLYNNPLGATIDDQPPNLQLELCDLQADMFLITRQEKGPEFFKLLSKEKFPNLRDFGLKMTSIFGSTYTCESAFSSMKYIKNKNRSNLTDSSLRHLMRLSTTELEVDISSLVDEADRPKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K149</accession>
    <name>A0ABM5K149_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503906.1">
        <property type="nucleotide sequence ID" value="XM_050647949.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050503906.1"/>
        <property type="gene ID" value="LOC126882885"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF69">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="69"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="447" mass="51201" checksum="A5829CC3C3CAAB99" modified="2025-10-08" version="1">MGEMDRENYSSNPLDHMPAYVWEAIHPLLLGVNDTELDLRRPHIKAVVINTYPYVIFIYGLLISVGVSGNLFMFAYIINKKLYKDETYSFLLNNALSDTVKCVVVLPLSLYVLLVKNWVLGELLCSFMPMIQDIPQHTSTLTFILLAWDRFRYIKKPLRPRLPAFVCNVGTWLTSGCLVLPYPMYIMYIDLGQVYPKLDLLQGVGLCTVNLLDDIKEYTRGIFIIMYAAPLTAILCFFIRVSRELSRQNPTAAIKFEARAKETKARIQDGLPTASTEVQSIRTDYDRSSQYSRGSFRDFDTARTLYEFREPDLNVIKERRTLRFLVAIIVLYGICLFPLMVLKVARLSIKETYANIAVFDVLYLIVVWIAFLPTCTTPLLFILWKLTSSSIDRIRGYLRLSSRKKRHSNETVTTVAGTPAFQPRKKSHVSEDNISDSNSCQQDLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K240</accession>
    <name>A0ABM5K240_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Helicase domino</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504256.1">
        <property type="nucleotide sequence ID" value="XM_050648299.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648299.1">
        <property type="protein sequence ID" value="XP_050504256.1"/>
        <property type="gene ID" value="LOC126883075"/>
    </dbReference>
    <dbReference type="GeneID" id="126883075"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="17">
        <location>
            <begin position="314"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="655"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1400"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="14">
        <location>
            <begin position="1872"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="529"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1951"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2079"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2526"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1686"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2081"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2526"/>
            <end position="2537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2549" mass="284743" checksum="33383DA5B0D5F42E" modified="2025-10-08" version="1">MSDETPGVGQGALPPREGQSLRLLAERPTSGATVRVAQVVGGQYVLTTQSHGMPALAQIAAGNPNVTRLISISPTRGGQSSPLRPSLANQSIVNVLTKSRPNPNVRLQLFQSGESSGNNVQHSPHSRSLKRPLSSTGEKKDSYASKLQHVMNHRIVRSKLMKEKYNEHLLEAYYLETGNNILDLYQFAKRPKTQAYLAYLKEHAIDPRDYPELQTTTTVTVPQTTPNTPTATSVSSLPGISHSYAIQTTSSTVTTPESNSNTSTPKSVSVKVKSTSLPNTVSQEMIVEKAKQEAYVVQRIADLQKEGIWSERRLPKVQEMPRPKAHWDFLIEEMVWLAADFAQERKWKKAAAKKCARMVQKYFQDKALAAQKAEKAHEQNLRRIAAFCAKEIKIFWNNVEKLVEYKQNTILEEKRKKALDQQLSFIVDQTEKYSQLLAEGMNKTAEQPPSSAPSRSVSRTQSDTEFDPDLQSDEDDEETIAREEALGNEGHKEEIEALQKESQMELDDLLEDDFLRDYLLNRDTIRFSESEDSDDDTDSKKESFKGDKEQSDDSESSKEEDTEDESEDESMKVTESVVKEEHDELKILVEDSQKEGEIKTEQDTKDDLINDAAAIAESIQPKGNTLSSTNVSTNIPFLLKYTLREYQHIGLDWLVTMFDRKLNGILADEMGLGKTIQTIALLAHLACEKENWGPHLIVVPTSVMLNWEMECKKWCPAFKILTYYGTQKERKFKRIGWTKPNAFHICITSYKLVIQDHQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFQTQQRLLLTGTPLQNNLMELWSLMHFLMPNVFQSHREFKEWFSNPVTGMIEGNSEYNESIIKRLHKVLRPFLLRRLKSEVEKQMPKKYEHVVMCRLSKRQRYLYDDYMSRAKTRETLTTGNLLSVINVLMQLRKVCNHPNLFEIRPTTSPFQCDNIRLHIPSIVYSALDYDPDKHVNLQALNLLLIMQEIHFGSYQCYRMRQSRNSKKIFEMETNSSKNPPPCPPCKLAMRVLTDKPSATDEKNEKKDMQALSQPPPLQVKGMSQPNMKMKVSGVQFVPQSILKSIPVVNISQGATGQIGAPVSVTSVLKPQDKISASFAQLVQTSTGKHLLLTSNPNITTSPVTTTTPGGQKLTFLSKQPVSTIGNAGHAVTKAYVKFQLTSVTTASTFTTVTTVNSNTISVAKSEDNKGMRMSVGNDYIGKLYSKQNSLDVRWNSGEKHLGLTNEDDPKGERKKRLSLMSRINKIRCSALPLYGRDFQEAVKIYTPNQLDVWNGGHIHCLNTLYNKDARNETTDCLQDALFNPERRLEALKDTFDRFIFYVPSVKVAEPELQVWHPPPSKYWGQKHEKQLIQKLFLKPATPLHSIASAMVTQFPDPRLIQYDCGKLQTLDILLRKLKLGSHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGTTKVDQRQVLMERFNGDKRIFAFILSTRSGGVGVNLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEENILKKANQKRLLGDLAIEGGNFTTAYFKSSTIQDLFNIDQNEESASARMSEVVELRKEREKALSTDLVHSADDKATVGALENAFEACEDDQDVQAAKTAKAEAVADLAEFDENIPLDDQEKEPEISKAEQEINNIIEKLTPIEKYAMNFIEATESAWSAEQLAAAAREIEEQKKEWEQNRLAAMREEEERRARELEEESDIITYSRDDATNQIWVSDNTMEQMPMWCPPTPPQQENDVYIDETMAFLYDTHVMSESQLPPIYVKREAKRNRIEAGFSESRRALKIPRKEEATNAPKSLFHSPNILKMKRELKLQKYRGLVRPSVPIPGKPNIQKPPTEQPLFHEWTIHEDMAILKVIQSFQGLPLNLIVSNLGHTPNWDFVADYVNTVSIAYRTPKQCRQRYENHLMQREEGKQLSLDNFMKKKKNKAGPVQKYPMPTKSSRSMRTSQMYTQDNNSSFSQIMADRFEALKALKKVPPPKLGVNNPLLNKTKHAPSPVLNECGIDIEHPVLPVDVAARRAERIAKEKKNMTPDQQIAARLQIMKNLMANQQASVAASSPTAQGTSGTSTPSTTAQVITQQNSSSAATTTAPVVSTAATPPNALRTQRIIASPIQTPTVVSVSGLSAAQLQAATQRLIVSAGSSGQGKVVATTTALQGKAIGQAQLAMIRQANIKQQLRLHTGNLPAQGVKTSTVTIGGQQTVVQFTQAQPRAQFIRQGTVTVGGKTGITRPVTESEVAQLLKKQHQLQQQKLSTSSGGTIQSLSPQVLAQAIQAGTSGASVATLVKTVSSTPGATQTVTIPVTGVSLSAQGKNLAPSLKTTNANQLRQFHLQQQLLAQKKLSGQKLSIAQVGKNNMQAQLIVGSKPLSTAMTVQQFQQVIRSPLNVSQGPVVLAKGPPTRVIPVNTQGSKQTIQVVAAGSSQALNTALRPQAGTSTLAGALTGIKVQGASGTTQQALLSQVSAALNQNVAGMRQGSPVRIQTSTGAPLVAVNVQNVQQQAASSSSNAAPQVTNPEQVSRYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3M9</accession>
    <name>A0ABM5K3M9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <location evidence="15">Coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504790.1">
        <property type="nucleotide sequence ID" value="XM_050648833.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504791.1">
        <property type="nucleotide sequence ID" value="XM_050648834.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648833.1">
        <property type="protein sequence ID" value="XP_050504790.1"/>
        <property type="gene ID" value="LOC114327547"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648834.1">
        <property type="protein sequence ID" value="XP_050504791.1"/>
        <property type="gene ID" value="LOC114327547"/>
    </dbReference>
    <dbReference type="GeneID" id="114327547"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0168">Coated pit</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028446" description="EGF-like domain-containing protein" evidence="20">
        <location>
            <begin position="18"/>
            <end position="4662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="4557"/>
            <end position="4583"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="648"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="692"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1350"/>
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        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1396"/>
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        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1439"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1485"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1665"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2016"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2099"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2371"/>
            <end position="2415"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="2416"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="3044"/>
            <end position="3082"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="3176"/>
            <end position="3218"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="3219"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="4024"/>
            <end position="4067"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="4068"/>
            <end position="4111"/>
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    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4234"/>
            <end position="4278"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4280"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4317"/>
            <end position="4350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4379"/>
            <end position="4414"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4428"/>
            <end position="4463"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4468"/>
            <end position="4505"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="4506"/>
            <end position="4541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="41"/>
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    </feature>
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        <location>
            <begin position="205"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="921"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="928"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1003"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1010"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1022"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1061"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1082"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1101"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
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    <feature type="disulfide bond" evidence="17">
        <location>
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
        <location>
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
        <location>
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    <feature type="disulfide bond" evidence="17">
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    <feature type="disulfide bond" evidence="17">
        <location>
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        <location>
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    <feature type="disulfide bond" evidence="17">
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        <location>
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    <feature type="disulfide bond" evidence="17">
        <location>
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    <feature type="disulfide bond" evidence="16">
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        <location>
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        <location>
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        <location>
            <begin position="4495"/>
            <end position="4504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="4510"/>
            <end position="4520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="4531"/>
            <end position="4540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="4662" mass="521202" checksum="5C26A0BC0D9C95C7" modified="2025-10-08" version="1">[encoded data, 4662 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4V5</accession>
    <name>A0ABM5K4V5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505223.1">
        <property type="nucleotide sequence ID" value="XM_050649266.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649266.1">
        <property type="protein sequence ID" value="XP_050505223.1"/>
        <property type="gene ID" value="LOC126883613"/>
    </dbReference>
    <dbReference type="GeneID" id="126883613"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="328" mass="38673" checksum="0EAD0720B630450F" modified="2025-10-08" version="1">MVGRMSKRDIVNIYRDQNISQSTIYRTIRECEEGIPCANLRKSGRPRILNHIREARLIEAAKNKIGVSQRKLVRRFHVGKTTVYRTLSSNNIIYRKRRKAPKYTEDQLERIPRCCRALRRVHFVNKLIVMDDEKYFTLSKSEMKGNDGFYTNDYENVPDEIKFKSKKKFEDKILVWCAISEAGFISQPYIGVGGEALNANIYIQRCLSKLLQFVNTHHANDQIVFWPDLASCHYARITRDWYETNNITFAPKPDNPPNLPQARPIEEFWAILSRKVYNNRWEAQNQEQLRRRIFTKIREIDAEVVQRMMQRVSGIIRQIENNGPFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5B0</accession>
    <name>A0ABM5K5B0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505381.1">
        <property type="nucleotide sequence ID" value="XM_050649424.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649424.1">
        <property type="protein sequence ID" value="XP_050505381.1"/>
        <property type="gene ID" value="LOC126883760"/>
    </dbReference>
    <dbReference type="GeneID" id="126883760"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="119"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="224" mass="25700" checksum="439440F7A2B8EA2D" modified="2025-10-08" version="1">MWKKNKPLSEAELYALLLSDSEEDDVAELDESNSEASDNDGCEPEAHEGNLSITEHENEDVLASTSENIDSERSNVSDVLCERRTWRYLGPKKGKTLACNLLQKNSGLTEKSQNIETCMDAFNLFFSDSMMSMILEYTNKRAIEFTAAYNIKKETKMKDWIEVDLVEMRAFFGILILCGRFRESHEKVHNLWSNTNQSLSRPIYKASLSRDRFISILKHIALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5J3</accession>
    <name>A0ABM5K5J3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505462.1">
        <property type="nucleotide sequence ID" value="XM_050649505.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649505.1">
        <property type="protein sequence ID" value="XP_050505462.1"/>
        <property type="gene ID" value="LOC126883830"/>
    </dbReference>
    <dbReference type="GeneID" id="126883830"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32155" checksum="EAD72139FD1FEB1A" modified="2025-10-08" version="1">MIKQAFLEAADSLFANFRNKDEIVSAIKSMQLSANTVMRRVEVMSNDIFLQLRTDLDNCVYFSLQLDESTDVVDTAQMAVFVRMVFSDFTFKEDLLKFIPLKGHTTGQELFSHLKNIISSQKIPISKMVGLTTDGAPAMVGCDKGLVALCRKDETFPQFLCYHCIIHQQALCGNFLKLNNVMKLVVKIVNKIRAQSLQRRLFRTLADEVDCQYGDLLLHSEVRWLSRGRVLKRFNDVLSGIVQFFKQRDEPTPELENSIWLRDFGFLVDITEKLNELKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5J4</accession>
    <name>A0ABM5K5J4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050505458.1">
        <property type="nucleotide sequence ID" value="XM_050649501.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649501.1">
        <property type="protein sequence ID" value="XP_050505458.1"/>
        <property type="gene ID" value="LOC114328902"/>
    </dbReference>
    <dbReference type="GeneID" id="114328902"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="228" mass="27428" checksum="424F30D8A9064CFA" modified="2025-10-08" version="1">MVKCYIWPVLLYDAEVWTLKVSIMNRSEELEIMWIYRRVLNISWTSTYKLIVVWYKSDELKDVFNIILTEFWPYDLMNGESNKQTKEMYNLMNTIKWAFIGGTCFYAAVFLIPPLFITNRLPYPVAYPFDWTATPWYHIVYFTQAFSHLITVSFIAPAADYMALGILLNISSQYCILQEYIEIFNTPEMYATNKRLREIMNDGLENKYTDERREYFVRFVRHHQLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6B8</accession>
    <name>A0ABM5K6B8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505737.1">
        <property type="nucleotide sequence ID" value="XM_050649780.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649780.1">
        <property type="protein sequence ID" value="XP_050505737.1"/>
        <property type="gene ID" value="LOC126884001"/>
    </dbReference>
    <dbReference type="GeneID" id="126884001"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="105" mass="12444" checksum="B20F9EA1436D94CA" modified="2025-10-08" version="1">MQSDYLFKEIIIGNSADVLERYSLKLKIIGDLDPYTIQSSELDFTVQSINYCHNAIIDRLVESHSYYFKQQMKAYKSLQAHKSLHNWICFETFDVLMIFILLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7L4</accession>
    <name>A0ABM5K7L4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050506181.1">
        <property type="nucleotide sequence ID" value="XM_050650224.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650224.1">
        <property type="protein sequence ID" value="XP_050506181.1"/>
        <property type="gene ID" value="LOC126884289"/>
    </dbReference>
    <dbReference type="GeneID" id="126884289"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="80"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="276"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="812" mass="92705" checksum="2F249773ED6FE01D" modified="2025-10-08" version="1">MTTVKEKSIKKEKKKVKVFNKSKKKQEPESVIIKKLTDQYETIESSAITKFGDFPLSAKTLKGLRECGYHKPTEIQRDTIGLALQGKDILGAAQTGSGKTLAFLVPILEILFTNQWTSLDGVGAIVITPTRELAYQIFETLRKVGEHHDFSAGLIIGGKDLKFERNRMDTCNIIICTPGRLLQHMDENPLFDCVKMKILVLDEADRCLDMGFEQTMNAIIANLPPKRQTLLFSATQTRSVKDLARLSLKDPSYVSVHENSEYSTPKELSQTYVVSKLDDKVAVLWSFLKNHPNKKIMVFFSSCKQVKYFFEIFSKLRPGTSLMSLYGTLHQLRRMEIYESFCRKQSAILFCTDLAARGLDFPEVHWVVQVDCPEDPETYIHRVGRTARYHRGGESFLMLLPSEVKMVDKLKEKKIPVEKIEINPMKLNNPVRKMEAFLAKDPSLKDSAQRAFVSYVKAVFLMKDKEVFDAQALDTDSFAKSLGLAIPPRIRFLQRMNARLKNQKEGKQTSGLINNHQNSKKYFDNDSDNEVNTNKQIKDDSDDSSVTEGDDTLKAHSASNPFQVSDNDSDNDDDNIFTVKRTDHDIELPTEKEMADLHIGRSKNKKPVSKAAAAKKILKKQIVPNKKIVFNEEGEALQSAKGKKSELAQQYENEDEGGIDIEKAKEVLREEDKFDKQLFKEKVKAKHKEEKRKLKEKKKMEEEEARDDFGDSDSEGDEPDLSWLPDPNKVYGEKTQEEIDQLEDNFNEDHDKRSVTKTSNRNQQKGAKKRKAEQEPDKKKKVNNKKQKIKEISSKLSVNEAEELAMLLLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7N0</accession>
    <name>A0ABM5K7N0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506192.1">
        <property type="nucleotide sequence ID" value="XM_050650235.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650235.1">
        <property type="protein sequence ID" value="XP_050506192.1"/>
        <property type="gene ID" value="LOC126884296"/>
    </dbReference>
    <dbReference type="GeneID" id="126884296"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="179"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="424" mass="48513" checksum="F1E11EC979FBBB17" modified="2025-10-08" version="1">MDQDDEIAAAAAAYIVLSAKKKKRKHKCWVKPSLCDRSEYGGMHLLNVLKKDDVYIGNNKNNGSVKNFLRMSSTDFEWLLCQIAPKIQKEDTNYRQAISPMERLLLTLRFLATGDSYHSLMYLFKISVSSISRIIPEVCKVIAEVLKDKLKMPQSREEWLITGHQFANLWNFPKCAGVMDGKHIMIQAPKHSGSEFYNYKSFFSVVLFIVANANYEVMYLNVGSQGCISDGGVFDSTHFKKMLYQNTLNLPELEPLPGRTKAVPFVFLGDDAFPLSPNLLKPYPGTQEKGSSKRIFNYRLSRARRISEMVFGIMSARFRVLRKPMLLEPDRVELVVAACVYLHNFLRSSLHSRKSYSPPGTFDSEDKDTGERIPGSWRNEINNNMFASLQKQARNSTLEAKQVRDEFAQYFMSPEGMVPWQNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9C0</accession>
    <name>A0ABM5K9C0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506786.1">
        <property type="nucleotide sequence ID" value="XM_050650829.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650829.1">
        <property type="protein sequence ID" value="XP_050506786.1"/>
        <property type="gene ID" value="LOC114327167"/>
    </dbReference>
    <dbReference type="GeneID" id="114327167"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031985">
        <property type="entry name" value="DUF4787"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35455:SF1">
        <property type="entry name" value="AGAP005842-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35455">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16029">
        <property type="entry name" value="DUF4787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046846934" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="106" mass="12567" checksum="CB4F7C7C21642FFA" modified="2025-10-08" version="1">MKAFNFLLIFFAIFYRNEAKVTYTFPEFQYKETNKNEVMFREVEAACQRGCHGRIGVSKILCIRQCISPSCYKELYHADLLEEGEVDVRLNSFKGCFIQRYNRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAC9</accession>
    <name>A0ABM5KAC9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507145.1">
        <property type="nucleotide sequence ID" value="XM_050651188.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651188.1">
        <property type="protein sequence ID" value="XP_050507145.1"/>
        <property type="gene ID" value="LOC126884882"/>
    </dbReference>
    <dbReference type="GeneID" id="126884882"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="321"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="747" mass="86321" checksum="BA3C19A4F9B0C6A0" modified="2025-10-08" version="1">MGFFENIRRGYGSASVDFLKQWANFNIKLASLNNRRIFLLKCRRNLCFPVHIENGKFNVNNLLHHKGGKLGSKIQNFNSNLKTKILNLEISVTISDITYIEKNLHQLKNILEQHLPAPLLQEFYRRQKIKYNKVFFQIRNNNIKKFNKIKIDQFSKITFQEKWFKNLTDITFPYNVKKLLSLGPKFCLFPSAKDFKMSSLLSDIEFLISGLELQEKDIMRSQSTNVITNFLHKTSKEGHFLNNIYNECKQFLKSHLEIYIVRSDKGNVTVAMYKNDYIEKSNSLLNDKKSYIELRNSPVCTLQQKANKLVSDLASSKSITTEAAKSLKIYNAVAPRFYTLPKVHKPTISMRPIVSSIDAPNSKLAKHLTDILTISYNESNEFYIRDSFTFSNFINNVKVPNNYILISLDVVSLFTNLPLDAILNSIKNNWNSISLHTKISLEDFIRILTFIFDSNIFLFNGNFFKQIFGTPMGSKISPILCNFVLDELITTCKEKIPFHIPFIKRYVDDLILSVPENKVSDVLNTFNAQCEHLKFTVEREADNMIPFLDMLIHRGSDGILRTEWYRKPCFSNRFINFHSQHPSRMKTNLVLALKSRVTNLSHIDFRDKGLKKLRSILLENSYPIGLLNKLIFGSPFPSQFSGKQNFHNNEVRQLTLTDSDNTSVIPPKITFGSLPYIPVLTPKLINIFRNVNGLKISTRNVKTVSKLYSKTKDPFTRQESSNVVYSIPCSNCNNVYIGETSRNFHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAT9</accession>
    <name>A0ABM5KAT9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507306.1">
        <property type="nucleotide sequence ID" value="XM_050651349.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651349.1">
        <property type="protein sequence ID" value="XP_050507306.1"/>
        <property type="gene ID" value="LOC126884968"/>
    </dbReference>
    <dbReference type="GeneID" id="126884968"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046726600" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="145" mass="16318" checksum="5F0E58142EEEFCF1" modified="2025-10-08" version="1">MKFILLLFLVAAVSARLPSREDLDLLASRHHSQVILPPPGSLAKLAPPDSLDRLPSGDRWHDWQEIPLRVIECYLPPEKDCENVGLDSYLAWTWDVTKNRCANVVAHGGCARTRNNFGSFQQCWHLAGPVCHNPIPVEPYGHNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC78</accession>
    <name>A0ABM5KC78_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDK5RAP1-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507794.1">
        <property type="nucleotide sequence ID" value="XM_050651837.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651837.1">
        <property type="protein sequence ID" value="XP_050507794.1"/>
        <property type="gene ID" value="LOC126885314"/>
    </dbReference>
    <dbReference type="GeneID" id="126885314"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01574">
        <property type="entry name" value="miaB-methiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="230"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="486"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="66512" checksum="7F68C5C20AE9B9E9" modified="2025-10-08" version="1">MQFTNKITNFYRYSLRNTNQLFLIRRCSVQKADVLPSNSTSESFTKKLTKGPNFTYFLQNGQLKPSTAPIVSEEIVPYVQNVPQQKRKVYFDIYGCQMNVNDVEIVWAILQNNFERTLNIVDADVILIMTCAIRDSAEEKIWGRLRYYRGIKSTRKKDRPSLKVGILGCMAERLKEKVLEKESLVDLVAGPDSYRHLPRLLTLTDNNQKSVNVLLSLEETYADITPVRLNENSISAFVSIMRGCDNMCTYCIVPFTRGRERSRPISSIICEIEHLSNQGVKEVTLLGQNVNSYRDTSIDNKIDNVTSLATGFKTVYRPKKGGLRFADLLKEVAKVNPEMRIRFTSPHPKDFSDDVIDMIKSHHNICKNLHMPAQSGSSAVLERMRRGYTREAYIDLIKHIRQFIPDVALSSDFICGFCGETDEEFDETISLMNEIKYNTAFLFPYSMREKTTAHRRFQDDIADEVKYSRLERMIEVFRQTALQLNQSQIGKTHLVLIEGYSKRSDKFFQGRNDNNIRVILPVTPVPSKESETLTELGAGDYVAVHVNDANSQTLRAVPLYKTSLSDYYLRDQFSSVNKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFG5</accession>
    <name>A0ABM5KFG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508941.1">
        <property type="nucleotide sequence ID" value="XM_050652984.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652984.1">
        <property type="protein sequence ID" value="XP_050508941.1"/>
        <property type="gene ID" value="LOC126886137"/>
    </dbReference>
    <dbReference type="GeneID" id="126886137"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="265" mass="30656" checksum="896807043F2415E3" modified="2025-10-08" version="1">MVSLDGEMIVKSNSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVVEMRMLRWMSGVTKKDKIRNEYIRGSLGVAPIDAKMREHRLRWFGHVQRRDVNHPIRRIAEVQISVMRKLKLFSPTSGSDCLKEISGYQHWYKMITTICLETAGKSLGFTIHHHHRRAGINLAGWETGKLLHDDGPKGTKTQLNSMMALGELFSMTMALKEPKLNSTRWWPWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFP8</accession>
    <name>A0ABM5KFP8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509022.1">
        <property type="nucleotide sequence ID" value="XM_050653065.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653065.1">
        <property type="protein sequence ID" value="XP_050509022.1"/>
        <property type="gene ID" value="LOC126886204"/>
    </dbReference>
    <dbReference type="GeneID" id="126886204"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="293" mass="34085" checksum="709DEFB97A3E6519" modified="2025-10-08" version="1">MILGFKCEDGHTGENNDLHNHVINNQLNQCTADVRKVNTVKKPFECQSDNNYKDQIRRHMIEQHTKEKSVTYETCSKQSKKVYTNIHSSEKHFTCEVCNRQYVSNGNLKQHMIIHTGKKPFECEICTKQFTQLSNLKVHMRRHIGEKPFECQVCTKQFLTNDHLKRHMLVHTGVKPFECEICTKQFARTADLKFHMSTHTGVKPFGCQVCTKQFLTNDHLKRHMFVHTGVKQFGCEICTKQFARSFNLKNHMRTHTGVKPFGCKICTKQFTRNAALKKHMVVHTGEKPFGCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG98</accession>
    <name>A0ABM5KG98_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509222.1">
        <property type="nucleotide sequence ID" value="XM_050653265.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653265.1">
        <property type="protein sequence ID" value="XP_050509222.1"/>
        <property type="gene ID" value="LOC126886374"/>
    </dbReference>
    <dbReference type="GeneID" id="126886374"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047358048" evidence="3">
        <location>
            <begin position="19"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="543" mass="60221" checksum="1FBC48513D1AC7B9" modified="2025-10-08" version="1">MYSRVVSFVIIFISLAASSPIEETSTRSSAIEEGRKASIDNKKTENVVLDLMDVRTPPRIKLKQEKLKYEHSHPGVAIPVDEDSINIEESTTKKFNFYKLERPTTDSSISTWILLSGQPLTTNKPTVINSTNSAADDNKKNDTIVPIYNRTTKPSMTVNASNGVKEKIKFTEISKFNQKKRKSTTTSPPPTTTVAEIKKTENKVPEVKEKSKIYSTSASVSVSSGHKPENDKHATKSKKKITTTTTAKAPLSTDSSSKDESPAATTNTVTKVSTSESNMVNTTATNSSSIALESKDGSVSLTTEKQKKTSSGKKKKNKRRRKPASKESTALTSTNKIKNKNNAIGAQIYNYLSREIVPSLGVGLVGLMVTAGLASYFLYPFGVARRNFDIDRKDKGNFFYKDEYSGGMLEEDAIGQVIAGMPDNKLFPQINSKSSIPKNNYLNKFYRSNVQTSPIQYSQPHKRFPQENVSALFEREDNKRFVENNDNKVNNNKEEKRFVVGSVQKEEIQKVTPAAVPEHGPRSLGLSRIPRMKQDSSESSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KH31</accession>
    <name>A0ABM5KH31_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509495.1">
        <property type="nucleotide sequence ID" value="XM_050653538.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653538.1">
        <property type="protein sequence ID" value="XP_050509495.1"/>
        <property type="gene ID" value="LOC114331519"/>
    </dbReference>
    <dbReference type="GeneID" id="114331519"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="851" mass="98192" checksum="A8AAC75A61AF2B2A" modified="2025-10-08" version="1">MDNDLDRSIRLLENALSTSNRGLFKKSFGKSKLATDNISNVSIASADDDLRNIISKSFLTSDNAVSRILQSDQTVTGNVLQASTAPWKTALDSLYTEFFEILTSHSGGFDILEVVTDLARCCSDALKVIQSLKSKVAVSQLEEEISLEKERNTWRLLFILYQDRLLTQNLMKDDNDEVIQYFGQSEKLCVLNLFKRDSLIRENQLIIDWLESNAADRDDEALLFSDSTVGWENTLHQLQSADTIAFSSSRQIVTQMDPDAPNHQKRPLHDLDAEDEKRLTERIFMEIRCGKLEEAQKLCRHCGHAWKAALYEGWRLFHDPNTKDEYESENTSDNNTDEEMDSDEMKDIEGNINRDIWKNMAIKFCKQEYLSLYERAAIATFCGYLSSILTVCNSWEDSLWAYMKTMVDIRVESEIRDCVQRNNDYLPLPEEYWNQKLSLNEIFSNLESSKNVRVREEARKPEHIIQKYIILDEIQTLLLKFEEWIEEDNVPTNFLRFLAHLVLFFEQIGQGHHRGIIEKVLEAYIRRIMLANETQLVAFYVSKLNPSNQVHLYAKYLEKIIDQQERKSALIFAEDSGLEVHAITKQVLENIRNLPHETEENGSLQHKITEVDKYKISCIDWILYYEEQRAEALFQINALIFAFLTLGKLDAAQLAFNKVPPNSVEKILNEGKVNDKINQTIKEFLCYKAYLDAQEAFSEWFKHRKSQPTPPDSLPENALFPEKVAHQHRESQYKAELGRWKLSADHMAKNAKAKLYNVLLFPDGWIVGAAEEYYLRSTCIPEVVLLLYAVLYESGQHEECVQLADILASEKYGIYKVYSKEKLGEILVKLCESSVALLNAKKDPWGNETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI44</accession>
    <name>A0ABM5KI44_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144173.2">
        <property type="nucleotide sequence ID" value="XM_028288372.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144174.2">
        <property type="nucleotide sequence ID" value="XM_028288373.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509793.1">
        <property type="nucleotide sequence ID" value="XM_050653836.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288372.2">
        <property type="protein sequence ID" value="XP_028144173.2"/>
        <property type="gene ID" value="LOC114337835"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288373.2">
        <property type="protein sequence ID" value="XP_028144174.2"/>
        <property type="gene ID" value="LOC114337835"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653836.1">
        <property type="protein sequence ID" value="XP_050509793.1"/>
        <property type="gene ID" value="LOC114337835"/>
    </dbReference>
    <dbReference type="GeneID" id="114337835"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22396">
        <property type="entry name" value="KH-I_FUBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22397">
        <property type="entry name" value="KH-I_FUBP_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22398">
        <property type="entry name" value="KH-I_FUBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015096">
        <property type="entry name" value="FUBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09005">
        <property type="entry name" value="FUBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="317"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="470"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="731"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="802" mass="82915" checksum="55397EF55BBEF3A8" modified="2025-10-08" version="1">MSDYSAVAPPPQNFNQSTAFAAAVQRAKQIAAKINPGTTGNDSRPKRPLEEVADEFDVEPDAKKGPASLLSSQLVPPGMGRPPQNQGMGGGGPPGMQQMSEDIKVPDKMVGLIIGRGGEQITRLQSETGCKIQMAPDSQGMSDRICSLSGPKDAVERAKQLIIDIIRHRGGPPGVSDDEMSYQNNHSDFQGITNMGGPGGPGGGPGPGGRNSIEIMLPGPKVGLIIGKGGETIKQLQEKSGAKMVVIQDGPNQEHEKPLVISGEPQKVEHAKQLVYDLMAEKEMKSFNRGGPRGRQNQGQNDGGGYGNNDYGGGGGGGEQMEVLVPRPAVGVVIGKGGDMIKKIQAETGAKVQFQQARDEGPGDRRCYLSGNPKQVEQARQRIDELIDSVLQRDGDGGGMGAPMGGGMRGGRGGGRGGRGGHHGGRGGGGQGGFDRGDRNGGGGDFGGGGNQWEDRRGGGGGPGGQGNGQQDVVSFTVPANKCGVIIGRGGETIKQINQQSGAYCELDRRAQNQNPTANDKVFNIKGDPDSIETAKRIIQEKVQMPLTFVSQSGGGGGGPPMNSTMPTAYPGMTPQNYNPQNNWGMQGGGGGGGVAGAGGYQQQQQWGGQPQGADSQPGQPNKVQVNPSTGQPDYSMQWAEYYRSLGMHREAEMIEQQAKAKTAGGSMQTAPTPAQPAASTQSANPSSQADYSAQWAEYYRSMGKHKEAEAIEAQMKTKGPMPGAAGGAATGQTPAAPGTQPGGYSQAQAPYGGYQPQAAAGGYYGGQPQSAPVPGGVPQGGYGFPSYGYGGQQQAPPQSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJT6</accession>
    <name>A0ABM5KJT6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510470.1">
        <property type="nucleotide sequence ID" value="XM_050654513.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654513.1">
        <property type="protein sequence ID" value="XP_050510470.1"/>
        <property type="gene ID" value="LOC126887151"/>
    </dbReference>
    <dbReference type="GeneID" id="126887151"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="287" mass="33280" checksum="B1FA05D143B980D5" modified="2025-10-08" version="1">MNDERLIQLVRQYPVLYDASHSKYMDYAGKQSKWDIIAYEMKVLNATECKQRWNYIRDSYRRSLRRTLTKGGYPKKHVYKYAKELEFLKKHLSEKNPKKIYETEITEQIDEQNESESMNDETNCERDSDFSHDSQEANNSTNKQMFEHIDLPVEDDEVPGLYEIEEPNLSQDTVSLQLLKYLTKNKDFKSATTEKHPVDLFLTFISRTLKSLDAYHLNLAKSEIFATAQKYEMQMILNQSSGQSTANQPNSPDHGRNSSPHSSCSKPFTLTPVILSGSIDPHNSENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKC5</accession>
    <name>A0ABM5KKC5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510655.1">
        <property type="nucleotide sequence ID" value="XM_050654698.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654698.1">
        <property type="protein sequence ID" value="XP_050510655.1"/>
        <property type="gene ID" value="LOC126887290"/>
    </dbReference>
    <dbReference type="GeneID" id="126887290"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="445" mass="48889" checksum="3CD96AEAED14E8FA" modified="2025-10-08" version="1">MRRQSILRTQTSEPLIVVEDDEYEEEKRDSSRQNSEDENSLNPYLLSPYAREIRKHSLPTPQCSGITASQVRRLSERGETAGPGPKQVEFLATLSTAPQPSSGGRRHSVVTISRVPPTLFGRNRRESVAAYPTSAFPGRVLPNRRESIACPSTEPRGSMHNLQLDIMDDIVQARKVRMKMWGTSNEQVCEVQPLDDSGNANVQRYTNSGRRFSDFVGTTLTPIPSMNKRRASELPSTPVAESSGMQSKAAPGIVCSNTDLISILSSLSTSATEINQCVQEKEKPVDVAKTAAQQKRSQLKSSRSNSFDISILNENVDPHDSKSTPSNWFVKRHQPIEKTETKAGSLKEKKEKKVIEKEPNKLLWDERSGSLVDPQALGSAIEVFLRKASPSDPPSGPLNISPTKSGGKSGSTKAAKNWFSKGEESSSTEACDSSICSTLKDLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLW7</accession>
    <name>A0ABM5KLW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511191.1">
        <property type="nucleotide sequence ID" value="XM_050655234.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655234.1">
        <property type="protein sequence ID" value="XP_050511191.1"/>
        <property type="gene ID" value="LOC114329409"/>
    </dbReference>
    <dbReference type="GeneID" id="114329409"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF15">
        <property type="entry name" value="SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="920" mass="106950" checksum="7E95D530FCCD9119" modified="2025-10-08" version="1">MATWNGSTETGILRKTNQTENFDDLLVFGYACKLFRDDEKALFIDQGKHLIPWMGDDTLKIDRYDGRGTLSDLRQYEASREGYDATRWLGLSEKDRNVEELCDKERYHSLIINEEEEQMYKEEELKRQKTNMFQYSYDVPQNPDIQEEGIPTVPEAEEEYVPPPILDLPVDIEWPNTVKENARIEKTALFVCKQGPQMEILLKAKQADNPQFSFLNQDGKLYKFYRHILSAFKNGRYQGYEAHTKSKNESISENQDQDSNSHYLHPSLVSSSTAEPAGTTAKSIPQIPYKPSVNCAYSQLVNRIQGNQAENQETQKIPEYEQMTYEQQQYYQYYYVQQYLEYYKQLALHYQGQAGNPGQFVPPADFQNLDPTLQHYIQQMAYTQYLQQFQQSNNSYAQIVSNVNKETNPYIANVPQLPQLPETVKNQEDERTVTIVGEKKKVEVNKPLLSLAAYGSGSDSDSDDSTESDDREVRTVTKVESTAAPTDETKIVIDKMALYVSKNGEQFEDIVKAKNDPRFEFLQSSHKFYKYYKETLKRFMDENNKNGQEKQETNKEKEVVKKPPKEKKERKVIAPVSFSIKKAKEELPKEIKSALPIEESSDEEEQASSENTETQKSPTPAAPHLLKNILWRIGDVQKPVIPPIQVQENASKNEEPKHEKIVSKNEEPKHEKIVSKNEEPKHEKHVSKNDQIGKKIVSINEDPILEMMEFLDGVEKQGAKKAEDKVKDKLAAVRDKLSVVATKDKALQLERKRKAAAFLKLKSAETNHQPEERTPERTEKDRTEKERTEKDITEKERTEKEKTPLRRDSDCIEVIELDSEDSPPKKKKHKKDKYKDRDESRSRSRDRDHKKEKKKHKNRDKRRSDSDDEEDENKKRKKKRKKSHKRKHSKSRYESKSKKKSKKRHKKSESESSNSSDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMB4</accession>
    <name>A0ABM5KMB4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511298.1">
        <property type="nucleotide sequence ID" value="XM_050655341.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655341.1">
        <property type="protein sequence ID" value="XP_050511298.1"/>
        <property type="gene ID" value="LOC126887691"/>
    </dbReference>
    <dbReference type="GeneID" id="126887691"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="304" mass="35709" checksum="C7207CD1BBD9FE20" modified="2025-10-08" version="1">MSSTNLLITDRNEIRKNYGKTEKDVLKDIDIIKEWLKTQKHLPEIPTNNMIEFFLTNNKFSIEKTKKNLDMYYTIYSLIPEMYRNVHPCKSDLEAAYNTGTAAFIPTLTPSKHRITVFRYENVDSANADITRIFAHVLKNMYEIRIQEDLAMGEIFVIDCKNLKLDIVLKITPVVLKQVAFIFENVQSFRLQAIHYYNTPGYFHSTITLLKSLLSKKLSERVYSHKTIDDLTKFIPLDLLPSDYGGKQKSVNELAELWKQKMFEYKDRFDQLESMKVNEELRPEKLQNDELLGYYGNFKKIDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRY8</accession>
    <name>A0ABM5KRY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512949.1">
        <property type="nucleotide sequence ID" value="XM_050656992.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656992.1">
        <property type="protein sequence ID" value="XP_050512949.1"/>
        <property type="gene ID" value="LOC114334003"/>
    </dbReference>
    <dbReference type="GeneID" id="114334003"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="112" mass="12655" checksum="BDEBDD4E52CCA1F7" modified="2025-10-08" version="1">MFVPNKRIDEKGKDTQVNEVVGIMRVNVEKVLERDQKLSELDSRADALQEGGKRFEQQAQKLKRKYWWKNIKMMIIMGVIGLIILIIIIISIANAVKGDDTTSSSVTSAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSM3</accession>
    <name>A0ABM5KSM3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513189.1">
        <property type="nucleotide sequence ID" value="XM_050657232.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657232.1">
        <property type="protein sequence ID" value="XP_050513189.1"/>
        <property type="gene ID" value="LOC114339668"/>
    </dbReference>
    <dbReference type="GeneID" id="114339668"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="47984" checksum="C217E121CE1EED1D" modified="2025-10-08" version="1">MCYNVLCDKYATRQMYSYCPSWALNWDYRKKGILEEIKHYGADIINLQEVEMEQFYNYFLPELKVDGYSGIYSPKSRAKHMAESERKYVDGCAIFFRDSKFTLVKEHLVEFNQLAMASADGMEHMLNRVMPKDNIGLAALLQTREAAWDNGRAPPDSPFFQQPILVCTAHIHWDPEFCDVKLIQTMMLSNELKTILEESVQTLKAHDINTDSSNIQLVLCGDFNSLPDSGVIEFLGTGRVAMEHKDFKTFSYKACLEKVLSCDKPNEFTHSFKLASAYNDEIMPFTNYTFDFKGIIDYIFYAKQTMTPLGLLGPLSQEWLQQNKVIGCPHPHIYSDHFPLLVELEMVPTITSSMNGLIGHRYQHISKDVRLPSNKFAVKQKYKTETFKPSLPSQKIPSPVVDLDSRHKSFTNSSKTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KTS9</accession>
    <name>A0ABM5KTS9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513593.1">
        <property type="nucleotide sequence ID" value="XM_050657636.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657636.1">
        <property type="protein sequence ID" value="XP_050513593.1"/>
        <property type="gene ID" value="LOC126889378"/>
    </dbReference>
    <dbReference type="GeneID" id="126889378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14998" checksum="DCBA3990153E2131" modified="2025-10-08" version="1">MDNEFFFVKNQESSSTLGDKNIAVPGVSKSTSSSSSSSSCCSRCSSRSSSSSSSSSSSEDCEDIINDHNYVPKSDEELEECDKENHDDGNNEPNQTLSANQDIPILVTPPKKGKKRQRNTKNWKRNLTKKNEKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW27</accession>
    <name>A0ABM5KW27_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514388.1">
        <property type="nucleotide sequence ID" value="XM_050658431.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514389.1">
        <property type="nucleotide sequence ID" value="XM_050658432.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658431.1">
        <property type="protein sequence ID" value="XP_050514388.1"/>
        <property type="gene ID" value="LOC126889797"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658432.1">
        <property type="protein sequence ID" value="XP_050514389.1"/>
        <property type="gene ID" value="LOC126889797"/>
    </dbReference>
    <dbReference type="GeneID" id="126889797"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010800">
        <property type="entry name" value="GRP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07172">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028523" evidence="2">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="95" mass="10289" checksum="B35BCA81CE370F99" modified="2025-10-08" version="1">MTKATKLIVLMVCFACISLYLMESVECKNYDPNPPPRSPSPQERGRSRTVPAHLQNQGQNGNGHQNGNGQQNGNGHTNGNGQQNGNGNGHHNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWE5</accession>
    <name>A0ABM5KWE5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regucalcin</fullName>
            <ecNumber evidence="8">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050514511.1">
        <property type="nucleotide sequence ID" value="XM_050658554.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658554.1">
        <property type="protein sequence ID" value="XP_050514511.1"/>
        <property type="gene ID" value="LOC126889872"/>
    </dbReference>
    <dbReference type="GeneID" id="126889872"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="15">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="328" mass="37596" checksum="FD81DA6CF6620BAF" modified="2025-10-08" version="1">MQLVKITTVIYILFFKYCYTYVIEKVTKALQHAEGPFWCPETRNLLYVDTFKSTLHRINIDNKKEKQPILLKNHRSIGFVIPINCTKERYLVFADHDVYDLRWSSNMTLLKKILTIEENKPKNQFNEGKADNRGRVWAGTLTRMENLGVALGGGSLYMIDNKLKVNLKLTNLSISNGLVWNKNFTKFYFIDSQTKNVDEYNYKEKSGTISKRRTVINIEDAGFEGIPDGLNIDLNGNLWVALFGGHYVLQVHPVTGEIIRKIKMPATYITSVIWGGNNFETLFVSTSRLWLNREQLEKEPDAGSIFAVKGLGVKGLRLNMAKIKNMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWK6</accession>
    <name>A0ABM5KWK6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514572.1">
        <property type="nucleotide sequence ID" value="XM_050658615.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658615.1">
        <property type="protein sequence ID" value="XP_050514572.1"/>
        <property type="gene ID" value="LOC114337832"/>
    </dbReference>
    <dbReference type="GeneID" id="114337832"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="166" mass="18602" checksum="159FC70497843923" modified="2025-10-08" version="1">MGPIWSAFGATNTGRTDDADSTTGLTSRDRYLLKSSWAGVMKNPTDNGVALLLLMFKKFPETKTVFPFKDIPNEELANNVRFRAHCNSVVYAITSMVDAIDDPSLLVGILEKVGRDHKRRSIPQKYFEGLQETIIELFSTFMKPNEINSWNKALGVIFKVVADNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXZ6</accession>
    <name>A0ABM5KXZ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein ALP1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050515047.1">
        <property type="nucleotide sequence ID" value="XM_050659090.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659090.1">
        <property type="protein sequence ID" value="XP_050515047.1"/>
        <property type="gene ID" value="LOC126890236"/>
    </dbReference>
    <dbReference type="GeneID" id="126890236"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="4">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="142"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35247" checksum="FD0F7FBCB1B14F2E" modified="2025-10-08" version="1">MANNSAHIDHPLQEIAASITGENSVSVAVQTDLTIEHLCLTYNVLSALYEDIGPLLSSKKALSPFQQLLLTFMKLRLNLPFKYISYTFCISPTTTSETFLSTLKILYLRLKHFVCWPSREQLRKNVPACFKEAFGNQVTVIIDCFEVFTETPSTVVNASQCWSNYKHLETVKFLIGITPQGTISYVSQAWGGRTSDKYLTENSDFFKLLLPGDVVLADRGFLVEDSIKILGAKLIIPAFTKGKSQLHPKDLEGTRNISTVRIHVERIIGLLKKKFKVFHQTIPISMLARQTVLDEMVIVCSALINLCDSQIPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0B9</accession>
    <name>A0ABM5L0B9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515887.1">
        <property type="nucleotide sequence ID" value="XM_050659930.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659930.1">
        <property type="protein sequence ID" value="XP_050515887.1"/>
        <property type="gene ID" value="LOC126890759"/>
    </dbReference>
    <dbReference type="GeneID" id="126890759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="23382" checksum="1B6260E5A5B51A9A" modified="2025-10-08" version="1">MRQESVVLEEWDGVSVAAGSGSSPRSRWRRSAGQQRSKLEAVSGTANGPRWRRSAGQRRSKLDGNQRESNGARWGRSAEQQRSKVEAVSGTATVQGGGDQRDSNGPRWRRSAGQQWSKVESISGTATVQGGDGQRDSNGLRWSRSAGQQRSKVEAVSGTATVQVEVIRSPEQPITIRFNFNTASLASGYADDSLNRPTRGTKLCVGRFTCGKRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0S5</accession>
    <name>A0ABM5L0S5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516043.1">
        <property type="nucleotide sequence ID" value="XM_050660086.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660086.1">
        <property type="protein sequence ID" value="XP_050516043.1"/>
        <property type="gene ID" value="LOC126890918"/>
    </dbReference>
    <dbReference type="GeneID" id="126890918"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="409" mass="47907" checksum="0D5FC0C7179CBEFD" modified="2025-10-08" version="1">MTGIHINFQNCRGLNTKTAEFYKNCLEGNYDVVVAVETWLREDMVDGELIDINVFNLLRSDRNQEISGKTKGGGVLMVIKKEHKILKVTQHCSSFEILVADLKINNKLSIKLIGVYIPPDCKLHDYANCFELLQTHITDINNTFIFGDFNIAEIKGTENLDFTNGSAKFKSMIEFLNFNSFWLYNNVKNWQGKTLDQVVASADNINSCKVCQEQLPLVKEDRLHPSLEIQLSFTVSSFRQTDKLVGNRFNFKKANFDLMCDLMRNMTWEDVTEEIEVDKALDIFYSKVLNIFEGSVPQYNIYKNYSNFPKWFTPDIKKLLKQKNNFRELRHVSIYFNNQFIETRKKLKSLINIEHRKYIRQIEENIENEFNNFWNFINNKSNQTEIFYFGGKEINQSDTANSLRAVRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2K2</accession>
    <name>A0ABM5L2K2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516667.1">
        <property type="nucleotide sequence ID" value="XM_050660710.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660710.1">
        <property type="protein sequence ID" value="XP_050516667.1"/>
        <property type="gene ID" value="LOC126891530"/>
    </dbReference>
    <dbReference type="GeneID" id="126891530"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="350" mass="38454" checksum="5FE14616B64FE280" modified="2025-10-08" version="1">MTSNNTMNTTQTISHISYSSVVNTFKQPTKDEAIVLSSIEGTKVQEYIIAVGSIVGPRNVSFASRIANNRICIYLSSKNMVDSLLHSHKYVNIKETQVEIRRLITPAQRLIISNAGPSVPTTLIEQELRKMSISAVSKMTFLRETECPDYANTITSNATTSNTTNLDSTNSNPPTSNTTNPDPTNSNPTTSKALPETSQNTQYITNLPYNQTEQKPSDKALISTSNDHPASSQNILDQIPDVQVSNNQLESTIETDDMSRPTNNTNETNTLKITTSSTSNKISNLTPLEITQPKIIPNVTKHPKRLILSSPEINENTTQTDSHIFTSPSIAPKLGHTQYNNVCNGCVRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L391</accession>
    <name>A0ABM5L391_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nitric oxide synthase</fullName>
            <ecNumber evidence="12">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Produces nitric oxide (NO) which is a messenger molecule with diverse functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12">Binds 1 FAD.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="12">Binds 1 FMN.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="12"/>
    <dbReference type="RefSeq" id="XP_050516916.1">
        <property type="nucleotide sequence ID" value="XM_050660959.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660959.1">
        <property type="protein sequence ID" value="XP_050516916.1"/>
        <property type="gene ID" value="LOC126891698"/>
    </dbReference>
    <dbReference type="GeneID" id="126891698"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 12" id="KW-0288">FMN</keyword>
    <keyword evidence="3 12" id="KW-0349">Heme</keyword>
    <keyword evidence="11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="13">
        <location>
            <begin position="492"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="739"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1163" mass="132021" checksum="CFD48B9B0123D345" modified="2025-10-08" version="1">MSMLNSNHVQQGPLKQNGTIVTSPLNHLPEIPLKKPIRLKNIASKNETFDSLHLSGVNEKTPCSERSCLGSVMALPQRTAVRVSEDVLEQAKDFLNQYFTSIRRQNTPAHEARWEQVKKEVTETGTYQLTETELIYGAKLAWRNASRCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYSTNKGNIRSAITIFPQRTDGKHDFRVWNPQLIAYAGYRQADGTVIGDPINVEFTDVCLQLGWKSKGSRWDILPLVLSANGHDPDFFDIPKEYVIEVPLVHPEFEWFKDFDLRWYCVPAVSNMMFDCGGIQFTAAPFNGWYMCTEIGSRDICDPQRLNMTEIVASRMGLDTRSPVTLWKDKALVECNLAVLHSFQLNGITIVDHHTASESFMKHLENENRLRNGCPADWVWIVPPLSGSITPVFHQEMALYYLKPSYEYQEPAWKTHQWDVSRKGDPNNKKPRRKFHFKQIARAVKFTSKLFGRALSRRIKATVLYATETGKSENFAKKLCELFGHAFNAQVYSMDDYDISNIEHEAMLLVVTSTFGNGNPPENGEEFAQNLYKMKMAQVGISNGEASSLSMATSKSFIKVNSQTEANAKYNQLDRLNSMKGSLNEALIDDTFGPLSNVRFAVFGLGSSAYPHFAAFGKYVDKLLGELGGERIMKLTTGDELCGLEQAFNEWAPQVFTVACDTFCLDDVVVDIDDARNRMDKELTEQNVRFLERPTTAPVEGLSKCHNKKINATKLIRRTNLHKKNDPKSTMLLEFSSTSSYKPGDHLAVYPLNRSELVDGVIKKLRGADNPDVPVELQLMEETTTSNGIVRNWKPHQRLPSCSIRELYQRYLDITTPATPNLLKYFASIATSEEDKKQLTLLATDSASYEEWRHWRYPHLLEVLNQFPSVLPHAALLSAQLSLLQPRYYSISSSQRLNPNEIHLTVAVVQYKTQDGASDLHYGVCSNYLKEVDLNTEVYTVVRSAPGFYLPTDESIPIIAVGPGTGIAPFRGFWQERAALLKEKPGNLGKMWLFFGCRTKDMDLFGEEKDEMVKLNVMDRTFLALSREPGEPKVYVQDLALQESAAIYQLLVKEKGHLYICGDITMAEDVYQTVQNIIQKEGKMRDSEVQSYMLALRDENRYHEDIFGVTLRTAEVHNRSRESARIRLATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L399</accession>
    <name>A0ABM5L399_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516914.1">
        <property type="nucleotide sequence ID" value="XM_050660957.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660957.1">
        <property type="protein sequence ID" value="XP_050516914.1"/>
        <property type="gene ID" value="LOC126891695"/>
    </dbReference>
    <dbReference type="GeneID" id="126891695"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="421" mass="48801" checksum="5B179AEAD110BBD9" modified="2025-10-08" version="1">MENRLSVEKSNQKMSRAQRIIESALKQISQDDVSQSYNETAVNNKIEIYDDATQTSGSTELAAPDLTAESQNDMSSNSAMQEEIITSCDDDYVDNTSEDENWEPLSKKSKQRYYNRVYSSDSEDTDTSSDRFSSNINKNCNASTHNVVISSSDSDIAETPKKRVRKRFRNELNWKKTAAKIKRNSGSSYINSSGKTIEAKSLKPPCSINCRLKCTEKINNQERQIIFNNFYALQDLTRQRDWIVRNIKKVQPKYRYTKEGSKRSYNNNYFFECNGSKIQVCRHFFLNTLDISKRTVSTALEKCNNEGFIEGERRGKHGKHIKLDDNLLQGMFNFINAIPRIESHYLRNQTTREYIDGGKTLSDLHRDYKLECQQNKTLFGNYTAFRKTFSEKFNISFLFRKKTIAVHVNNIKIVQKMKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4H6</accession>
    <name>A0ABM5L4H6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517335.1">
        <property type="nucleotide sequence ID" value="XM_050661378.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661378.1">
        <property type="protein sequence ID" value="XP_050517335.1"/>
        <property type="gene ID" value="LOC126891995"/>
    </dbReference>
    <dbReference type="GeneID" id="126891995"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="314" mass="35936" checksum="F69F1EF8A040C5E7" modified="2025-10-08" version="1">MECFVLLGIEAVPAKWYDKANKLCKFPPVDDHTEKELSNFIIEEYDPLEEWPIHEAVLENQTEFVLFNKAHIRASKACNSQNYKSDKETVLPQKRPPKPRKIVSSSSEQDSDGSDLVFEHSFPKSKKEQHEKCTPSKSRTHPNIGLENKQEVKTVQETSKPTPTNANAQETAISYLIRIKRTLELQEQKLIEIDRKVDELSTIIRGQQKSTDITDDEVHKKLPLSTLEELGDVEKLLENATNLDNFVIYMRQVGGFDYKESVRRCLKKIFNDQLAIIYSFQGHKGKNPFNKTLICTAVITLIAQGRPMDVLHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1W2</accession>
    <name>A0A6P7F1W2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114325446</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129321.1">
        <property type="nucleotide sequence ID" value="XM_028273520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1W2"/>
    <dbReference type="FunCoup" id="A0A6P7F1W2">
        <property type="interactions" value="1482"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273520.1">
        <property type="protein sequence ID" value="XP_028129321.1"/>
        <property type="gene ID" value="LOC114325446"/>
    </dbReference>
    <dbReference type="GeneID" id="114325446"/>
    <dbReference type="KEGG" id="dvv:114325446"/>
    <dbReference type="CTD" id="36951"/>
    <dbReference type="InParanoid" id="A0A6P7F1W2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028129321.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26551" checksum="04173526E456CA66" modified="2020-12-02" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTSGGVVLAVEKRITSPLMEPTTIEKIVEVDKHIGCAVSGLMADSRTMIDRARVECQNHWFVYNENISVESCAQGVSNLAIQFGDSDEDGAAMSRPFGVAILFAGIDEKGPQLYHMDPSGTFVQFDAKAIGSGSEGAQQSLQEAYHRSMTLEEATTTALTILKQVMEEKLNSSNVEVMTMTPKDMFHMFTKEQVEEVIAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F389</accession>
    <name>A0A6P7F389_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114325438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129312.1">
        <property type="nucleotide sequence ID" value="XM_028273511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F389"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273511.2">
        <property type="protein sequence ID" value="XP_028129312.1"/>
        <property type="gene ID" value="LOC114325438"/>
    </dbReference>
    <dbReference type="GeneID" id="114325438"/>
    <dbReference type="KEGG" id="dvv:114325438"/>
    <dbReference type="InParanoid" id="A0A6P7F389"/>
    <dbReference type="OrthoDB" id="5219169at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028200024" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129312.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16561" checksum="206C264645E1C650" modified="2020-12-02" version="1">MSGTLKWILLLIVVTIRAQDPRRRSFYFCSNNDYLELTKADNEKLACPDGRCIAKRFDSDEGPFWANRGKKDPTYLNVPLYAEEPYWVLLKNENQAQGDPFFLSRGKKETGSIFSSKLRDARDFAPDNDTPFFAARGKRVKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7F7</accession>
    <name>A0A6P7F7F7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endocuticle structural glycoprotein ABD-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114325702</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129633.1">
        <property type="nucleotide sequence ID" value="XM_028273832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7F7"/>
    <dbReference type="FunCoup" id="A0A6P7F7F7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273832.2">
        <property type="protein sequence ID" value="XP_028129633.1"/>
        <property type="gene ID" value="LOC114325702"/>
    </dbReference>
    <dbReference type="GeneID" id="114325702"/>
    <dbReference type="KEGG" id="dvv:114325702"/>
    <dbReference type="InParanoid" id="A0A6P7F7F7"/>
    <dbReference type="OrthoDB" id="6815232at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028184456" evidence="3">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028129633.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12414" checksum="B8EE7BE182D9148B" modified="2020-12-02" version="1">MFKVALFVIACLAFAQARPQADSKILRFDNDVRPDGYQFAFETSDGIRREENGVFQPTSDEEGVLTVNGESNYPLGDGLPFYITFVADDKGYRPKYVIGQGAPGNAGPGRVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBG9</accession>
    <name>A0A6P7FBG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114326580</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028130785.1">
        <property type="nucleotide sequence ID" value="XM_028274984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBG9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274984.2">
        <property type="protein sequence ID" value="XP_028130785.1"/>
        <property type="gene ID" value="LOC114326580"/>
    </dbReference>
    <dbReference type="GeneID" id="114326580"/>
    <dbReference type="KEGG" id="dvv:114326580"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="238"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="619"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028130785.1"/>
        </source>
    </evidence>
    <sequence length="960" mass="109634" checksum="857148FC8A504B32" modified="2020-12-02" version="1">MSRCAKTVVILLFVFICSTYVLSLLAGFGEKFFSGEFNEVEIWLKQNQLEQYTGLFKQKGISQLAQCGQLGELPELPAPDEQRLQRAALVLQQRLVLRQWLYKYNLHSYYPKLLPVEVTSLEDVYWLEDNKAKQVFTKDFPRWSSARQSLPISKQRLEVLKADLWSEVVKSSHHQDAWTWGGMLVVSVSVAGLVTLAAMTQPSLAPEAKHSLLQYVTGKYLLPSNCKVNFQWSCHHPVGQTVCFTVQFYQRNGQPYPICDTDNFTVDIRGGARKLAVITELGSPTDPNSANVAKVKFTVRHAGQYRISVMVGTQHVAGSPFTTIFVAGPAFAQRTMVVRHCSTVVCTANVAHLLYIEPRDEYSNICRYASGDNPTEGYTIDIMQLGTQSQENELEIDKENFTTSLDYDWESQRVSVQLKFIREGCYHATIYYHGSELHNGDFDIIVLNSIDSTLVHRNVASKNHNICYDAKLVGINGERIPKPKKILCYVSPKQLIIKELILKFIPKRLFTFRLCPSTKFNFHADTLKFSEFYSSSFTVDDGCQPKIELVSKDRNVIAATFAQFLLKNMGGSETFKDKQDFFYHEVRKFHHKHYHEKLSMKVSREKLLESSMKSTKSFSVADWCKNFEVNFQGEQGIDWGGLRREWFELICEQLFDPKNTLFTSFHEGQQSLVHPNPARGPHLKLKHYEFAGKVVGKCLYESALGGSYRQLVRARFTRSFLAQVIGLRVHYKYFEQDDPDLYLSKIKYLLENNMDDLETELYFVEEQYDSNGQLFRIVELVPNGSKIRVSNSTKLQYLDALAQYRLATSIKDEMEAFLRGLNELIPDNLLSIFDENELELLLCGTGQYSIADFKAHHVVNGNSTEFRRIVGWFWAAVGNFTQEEMARLLQFTTGCSQLPPGGFRDLTPRFQITAAPTFGNLPTAHTCFNQLCLPDYDSYEHFEKSLLLAISEGTEGFGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBT0</accession>
    <name>A0A6P7FBT0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-crystallin A chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328661</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133379.1">
        <property type="nucleotide sequence ID" value="XM_028277578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBT0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277578.2">
        <property type="protein sequence ID" value="XP_028133379.1"/>
        <property type="gene ID" value="LOC114328661"/>
    </dbReference>
    <dbReference type="GeneID" id="114328661"/>
    <dbReference type="KEGG" id="dvv:114328661"/>
    <dbReference type="InParanoid" id="A0A6P7FBT0"/>
    <dbReference type="OrthoDB" id="6716593at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF34">
        <property type="entry name" value="PROTEIN LETHAL(2)ESSENTIAL FOR LIFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028133379.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16597" checksum="E9BA572D94F8E75D" modified="2020-12-02" version="1">MSWIWKSSKLQVPIKPCLSFLEDKCFHKARLTLKEFGVNWLDLIQAQDKVNNNSAFHKMDAVFFHQDRFELLVDARGFRPEDIKCKMTTNLVEIIGQRQEALNSGSKSMSLSRNYHLPQHVKPEDGNCCFSAEGILLVTAPWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEN1</accession>
    <name>A0A6P7FEN1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Collagen alpha-2(I) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327380</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131778.1">
        <property type="nucleotide sequence ID" value="XM_028275977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275977.2">
        <property type="protein sequence ID" value="XP_028131778.1"/>
        <property type="gene ID" value="LOC114327380"/>
    </dbReference>
    <dbReference type="GeneID" id="114327380"/>
    <dbReference type="KEGG" id="dvv:114327380"/>
    <dbReference type="InParanoid" id="A0A6P7FEN1"/>
    <dbReference type="OrthoDB" id="6776414at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027589169" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028131778.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="11067" checksum="865AF0E6CA980C44" modified="2020-12-02" version="1">MNSLVILAFACMAATASASVVGLGWGAGLGGLGWGHGAGIINPHALSPIGPSGIVTGAGAAGPSGVVTGAGAVGPSGVVNGHGAVGPTGPNGVGVWGAPALALGHAGLGVGGWGHGWGAGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FF17</accession>
    <name>A0A6P7FF17_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Tubulin polyglutamylase TTLL4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC114327501</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131940.1">
        <property type="nucleotide sequence ID" value="XM_028276139.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131941.1">
        <property type="nucleotide sequence ID" value="XM_028276140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FF17"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276139.2">
        <property type="protein sequence ID" value="XP_028131940.1"/>
        <property type="gene ID" value="LOC114327501"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276140.2">
        <property type="protein sequence ID" value="XP_028131941.1"/>
        <property type="gene ID" value="LOC114327501"/>
    </dbReference>
    <dbReference type="GeneID" id="114327501"/>
    <dbReference type="KEGG" id="dvv:114327501"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028131940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028131941.1"/>
        </source>
    </evidence>
    <sequence length="992" mass="113813" checksum="97C1AAEA7C401765" modified="2020-12-02" version="1">MGDCNFDRYSKEEKFSYRTWCSMCERGPQRRRSISETNEPCRRKSKELKTLTPKKYNRSQEYENMEFEYELKGQWQEKDMRYEFSRIRSNLCELPTSYISNNCQLSNNLAGLPKLSNESTGFECCKSAGTYETSGKFADIDDQIENLGSMQGKGKSRLEPVKISKIEIPTFQKKSEVRSPDKSITSHSYNNTSPRGHLYSRSDLLDKYPSPNKFKTSSSASPYCNEFCSYSNFKMHTLSNQIPVCFDTSTYFNKRCEAIPDKYTREIQDLREKLLSLKSTSYICSDSLVFNPSTAVIKTTVPRSNTNGIQNELKSNTDTNFISNNYKEGKCLQMKGSVAAPEPSPTAALKTHRSKVSLKTRAKLGNHKVRKVKPKAIHNIPTLSDDVNSDCSGSDSENETNLDDEAGNTDENSTDKSDDSSESCTSLNVIETGSGDAVNWPIRQSLFPNIPPYIRFKLHDVEAEVQIPNAKKYFKWKLSTITPLIVRKTLTNTGFVLIRSEFSRESNQWLGTWGKHMKSPMFKTLKETQKLNHFPGTFQLGRKDRLWRNFQRMMTKFGAKEFGFLPHTYILPQELKLLKQCWEYKNGNGGEMWIIKPPASARGVGIKVINKWSQLPKKSSLIVQKYISNPYLINGSKFDLRLYVLVTSFNPLIIYMYKEGLARFASAKYSSDTKDLKDRYMHLTNYSINKFSSQYTANEDANACQGHKWTISKLMEYLQGYNVDTKALWRNLQQLVIKTIIACESPVVQLCEENINSRYNCYELFGIDILLDDKLRPWLLEVNISPSLHSASPLDAHVKGPLVQSIFDLAQFHLPSRISALKHGNLPECFDARLYSTALTKREKNKHALFEQLETRDEYLTDILRNLTGDDVRHLIRAEDELTVKGGFERIFPTQQSHKYLHFMEPRYYNRLFDAWEERYGHQREAGIAVLRTLCAQRIHLKVPVQSTLSKSSPNMTPLDTNVLPSKMEHPNPPLEDMFKHATINSTISTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFV3</accession>
    <name>A0A6P7FFV3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114327633</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132103.1">
        <property type="nucleotide sequence ID" value="XM_028276302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFV3"/>
    <dbReference type="FunCoup" id="A0A6P7FFV3">
        <property type="interactions" value="2769"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276302.2">
        <property type="protein sequence ID" value="XP_028132103.1"/>
        <property type="gene ID" value="LOC114327633"/>
    </dbReference>
    <dbReference type="GeneID" id="114327633"/>
    <dbReference type="KEGG" id="dvv:114327633"/>
    <dbReference type="CTD" id="33989"/>
    <dbReference type="InParanoid" id="A0A6P7FFV3"/>
    <dbReference type="OrthoDB" id="8123449at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000090">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="216"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028132103.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="65424" checksum="E55AC4850C31A996" modified="2020-12-02" version="1">MAEDLDVEAMLEAPYKKDDEYTSSKSRETREVSKKRSEKKRRSTSRSRRSTSRGRRSTSRSNRSTSRGRRSTSRSRRSTSRSRRSTSRSKRSRSKERRRSKERRRSVEKRRRSRDRKRRSSSKDRKSRSRDRRDRSKSKDRRSRSRDRRSRSRDRKKRERRERSRTPKERKPSPKRRTPSPTPFGKPPFLKRPRSPLGIRGTSPLEELSAEERDARTVFIMQLSQRIRARDLEDFFSSVGKVRDVRMIVCNKTRRFKGIAYIEFKDPESVALALGLSGQKLLGIPIIVQHTQAEKNRMGNSMPNMLPKGMIGPMRLYVGSLHFNITEEMLRGIFEPFGKIDSIQLVQDPETGRSKGYGFITYHSCDDAKKALEQLNGFELAGRPMKVGNVTERLDLQQQGPSILDSDELDRSGIDLGATGRLQLMFKLAEGAGMQVPQAAANALSMATGQPVIPQVQTNSTPPIATQCFMLSNMFDPSTESNPSWDIEVRDDVIEECNKHGGVLHVYVDKGSPQGNVYVKCPSIATAVASVNTLHGRWFAGRVITAAYVPLLNYHSLFPDAMTTTTLLLPSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIM9</accession>
    <name>A0A6P7FIM9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Antifreeze protein Maxi-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114330740</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135954.1">
        <property type="nucleotide sequence ID" value="XM_028280153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIM9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280153.1">
        <property type="protein sequence ID" value="XP_028135954.1"/>
        <property type="gene ID" value="LOC114330740"/>
    </dbReference>
    <dbReference type="GeneID" id="114330740"/>
    <dbReference type="KEGG" id="dvv:114330740"/>
    <dbReference type="InParanoid" id="A0A6P7FIM9"/>
    <dbReference type="OrthoDB" id="8197027at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007999">
        <property type="entry name" value="DUF745"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161:SF3">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05335">
        <property type="entry name" value="DUF745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027650765" evidence="3">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028135954.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="31076" checksum="C613A285956D25AA" modified="2020-12-02" version="1">MIWMLFLIAALLPIQQSLEYDDIDILTNYDVQFAQLADNQATPKKKQGFSAGSSLRSIAEGSSNAADDAVNNQDAAGHQAAYVAKNTLAQSAAAASATAQAALAGKQILLQGMEQQFRDAQTALMGEKQQLMQAQRAADQTNRAAQEARTHVQVLQNTLNAAQAAADHVTQAANEAAGELAAQQAMVGSAMDRLENIGKQLAAVRIDFEATRAAAMKAQAAAQAAAANAAAAAAAAAAGLAKNAGKQPPPPPPPPPPKADNGGGGKKGGGSGGSGGNGGKSSKYSADADYDQNSFYHPLFYGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJI0</accession>
    <name>A0A6P7FJI0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">B2 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114328637</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May be a carrier protein for lipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133350.1">
        <property type="nucleotide sequence ID" value="XM_028277549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJI0"/>
    <dbReference type="FunCoup" id="A0A6P7FJI0">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277549.2">
        <property type="protein sequence ID" value="XP_028133350.1"/>
        <property type="gene ID" value="LOC114328637"/>
    </dbReference>
    <dbReference type="GeneID" id="114328637"/>
    <dbReference type="KEGG" id="dvv:114328637"/>
    <dbReference type="InParanoid" id="A0A6P7FJI0"/>
    <dbReference type="OrthoDB" id="6693014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028429778" evidence="7">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028133350.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14982" checksum="EF229ADA7B15E8E2" modified="2020-12-02" version="1">MNTYCVIFFLAVAFLSGIESISEAEQAMMFELHQKCLPISGATDEMAKQAMTGNFPEDPAFKEHVFCMSKGFGFFNEKGEVNTAVVEGELNKRVPDPALREEIRTKCLVMKETPQETAFQTAKCMFAYKDKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK59</accession>
    <name>A0A6P7FK59_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bromodomain-containing protein DDB_G0280777-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114328794</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133555.1">
        <property type="nucleotide sequence ID" value="XM_028277754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK59"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277754.2">
        <property type="protein sequence ID" value="XP_028133555.1"/>
        <property type="gene ID" value="LOC114328794"/>
    </dbReference>
    <dbReference type="GeneID" id="114328794"/>
    <dbReference type="KEGG" id="dvv:114328794"/>
    <dbReference type="InParanoid" id="A0A6P7FK59"/>
    <dbReference type="OrthoDB" id="6786915at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028249504" evidence="1">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133555.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="57995" checksum="0F4D9DA7D75DCA45" modified="2020-12-02" version="1">MKFFILLSLVALCSCSPAHQKQNKYEQSKNAVQGNNPYNTFWKTYSQQRQGEEPWNQWAQYGQDNQAGNYWRQYVQGKNQVGGATVPWIYHYWDNQDYENLSPAQRVQLVLNYMQVHQQWNQLNSDVNNEDYLHQLMYQHLPEYVQYNHEDVLPHLVQYFEQNPARYTNMLHQAYQYSQSQQQLMYHVMYQLYQHYGQAPWSQEQIRNQIVKYQSVYPHQLSQGQIEQLVEFVYHIQQELTPRHYQQLEQVQPQLENYLEQSPMSHQQYPWSQRQLMYHVMYELYHHYGQAPWSQEQIRNHIVQYQNAFPNQLSQEQIEQLVGFVYNIQQELMPMHYQQLEQMQPWGQYTAQPSNYQTYYSRNNQNGLSWTYRQAQQGYGSAQPWTYRQTQQGYQSAQPWTYSQTQQRYEAAQPWSYRQTQQGYEGAQPWSHYQTVSQTYGNPLAQYYSNQQNQQPWTQYWNRYGQQYQHQQQYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKY6</accession>
    <name>A0A6P7FKY6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein 1.8-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glycine-rich cell wall structural protein 1.8-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114331449</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136833.1">
        <property type="nucleotide sequence ID" value="XM_028281032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136834.1">
        <property type="nucleotide sequence ID" value="XM_028281033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKY6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281032.2">
        <property type="protein sequence ID" value="XP_028136833.1"/>
        <property type="gene ID" value="LOC114331449"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281033.2">
        <property type="protein sequence ID" value="XP_028136834.1"/>
        <property type="gene ID" value="LOC114331449"/>
    </dbReference>
    <dbReference type="GeneID" id="114331449"/>
    <dbReference type="KEGG" id="dvv:114331449"/>
    <dbReference type="OrthoDB" id="10663895at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650944" evidence="1">
        <location>
            <begin position="17"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028136833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028136834.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="35595" checksum="1ED35254605D116F" modified="2020-12-02" version="1">MKGFVVFAVLFVAAFAAEVSVEENIPLREESSAAVVDENVKVQQSPELVQPIDVHTTAVQTTNVDTISGPPRPKRTLGVLLGAKALGAGLIGAKALGAGLIGAKVLGAGLIGAKALGAGIIGGKILGAGLVAGGLYAGGYGHGGYGGYGHGGYGGYGHGGYGGGYESYGGYGGGYYGGGHGGYYGPSYHSYPTTTVVEEYYVPVSSGYGGHGGYGGYSGGYGGSSYGGYGHGGYGHGGYGHGGYGGSVGYGQGGYGGNYGYGQGGYGGSYGGSSGGYGQGGYGGSYGGSSGGYGQGGYGGSYGGSSGGYGQGGHGGYVGGGESYGGNGGYGGQSYGGGCGGSCGGSRGGQISAYSKGSGYQYEKGYSQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLV2</accession>
    <name>A0A6P7FLV2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein SCO1 homolog, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114331609</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137021.1">
        <property type="nucleotide sequence ID" value="XM_028281220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLV2"/>
    <dbReference type="FunCoup" id="A0A6P7FLV2">
        <property type="interactions" value="1558"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281220.2">
        <property type="protein sequence ID" value="XP_028137021.1"/>
        <property type="gene ID" value="LOC114331609"/>
    </dbReference>
    <dbReference type="GeneID" id="114331609"/>
    <dbReference type="KEGG" id="dvv:114331609"/>
    <dbReference type="CTD" id="33711"/>
    <dbReference type="InParanoid" id="A0A6P7FLV2"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 8 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028137021.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30295" checksum="7B9080F12A734A7D" modified="2020-12-02" version="1">MSCYNVIKSLNGQLLRRSSIYFQSAEVALPSRIHQNARKYSNNTPFPKPKPPGRGIGPITWKNLGITAVLGGGLLAFMWYLKKEKEEAQMKERQRMLGKAAIGGSFELVDSTGKIRNSDEFLGKWLLIYFGFTHCPDICPDELEKMAGVIDILDKAEDMPKIQPLFISVDPNRDTPEVVGKYCKEFSPRLLGLTGSEQQVGQACKAYRVYFSAGPKDSDSDYIVDHTIIMYLVNPEGGFVDYYGQNRTASEISTSIRVHVLKHTTSKSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNU2</accession>
    <name>A0A6P7FNU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329642</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329642</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134620.1">
        <property type="nucleotide sequence ID" value="XM_028278819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278819.2">
        <property type="protein sequence ID" value="XP_028134620.1"/>
        <property type="gene ID" value="LOC114329642"/>
    </dbReference>
    <dbReference type="GeneID" id="114329642"/>
    <dbReference type="KEGG" id="dvv:114329642"/>
    <dbReference type="InParanoid" id="A0A6P7FNU2"/>
    <dbReference type="OrthoDB" id="8180611at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21253">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21253:SF0">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027664812" evidence="1">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028134620.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20670" checksum="37BE0C87A00C148B" modified="2020-12-02" version="1">MLLLFLVLMLMNHLCICSTKNDVTVIKRNILSRKKRYLVFPKGSTLVIQLSAIKAIQQAQPRGWNFLEELEFPFFLPDDPNMFRRKNRNRREVYATIKNGLTKYGFDGRTCIDNLICDIKQFTKSQKTSMNEEILFEIFRYLGENTNFEEVCTGETNLQCSYSILQYFLQGINILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTQ9</accession>
    <name>A0A6P7FTQ9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glucose dehydrogenase [FAD, quinone]-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114332574</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138197.1">
        <property type="nucleotide sequence ID" value="XM_028282396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTQ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282396.2">
        <property type="protein sequence ID" value="XP_028138197.1"/>
        <property type="gene ID" value="LOC114332574"/>
    </dbReference>
    <dbReference type="GeneID" id="114332574"/>
    <dbReference type="KEGG" id="dvv:114332574"/>
    <dbReference type="InParanoid" id="A0A6P7FTQ9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028138197.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="68943" checksum="2C2AC9DE3641BCCC" modified="2020-12-02" version="1">MNPNTICAVNTCPGNLRNASAALFFALINTITAAKCSFASPNDYPEDYGPFLKDEDEFDFIVVGSGSGGSIVANQLSQNQNWRVLVLEAGGIPSANSDIPALLFSLQRSEEDWRYKTQQTQGPKGSCLGGNDKQCNWPRGKTLGGSSSINAMIYIKANKKDYDEWADMGNPGWDWKNVKDYFTQLENVQPPDDKITHLGTKGLLPITKTRHNSPLRKSMNKGFLELGVPILSEQNPENPIGTVDAPICVHNGIRSNTGREILGAVKNRKNLFTSLHSMVHKLIIDPKTKMTKGVEVKVGNTTLRLRAKKEVILSAGTVGSAQLLMLSGVGPKQHLTDLGIETIKDLPVGKNLQDHLMFVAYELKLDLNAIVPFDPIDAIYEYFKHKTGPLSNIGLTNYLNFVNTRNDSIWPSISYHNLILNPNDESTFYMLFRAHNIPDEVIKEKIKICKDRPCLAHMPVLLSPKSRGEILLNSTSVYDHPLINTGYLTDEDDEDLQVFLEAIRFSDELFFKTEALKVHNPELIRPIAPACDSYKYQSDDYWKCVLRHYAITIYHPSSTCTMGPDENTAVVDSRLRVHGIKNLRVVDASIMPRLVSGNTHAPTMMIGLKGADIIKEDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW93</accession>
    <name>A0A6P7FW93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114334796</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the complex I NDUFA10 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140691.1">
        <property type="nucleotide sequence ID" value="XM_028284890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW93"/>
    <dbReference type="FunCoup" id="A0A6P7FW93">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284890.2">
        <property type="protein sequence ID" value="XP_028140691.1"/>
        <property type="gene ID" value="LOC114334796"/>
    </dbReference>
    <dbReference type="GeneID" id="114334796"/>
    <dbReference type="KEGG" id="dvv:114334796"/>
    <dbReference type="CTD" id="42591"/>
    <dbReference type="InParanoid" id="A0A6P7FW93"/>
    <dbReference type="OrthoDB" id="17400at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015828">
        <property type="entry name" value="NDUFA10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF15">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000543">
        <property type="entry name" value="NADH_UQ_42KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="14">
        <location>
            <begin position="78"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028140691.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47469" checksum="F2E80B253D5F8B1A" modified="2020-12-02" version="1">MSTFVRVGFGRVNQGLCNVLNKTQNVTLIRAISSKNTRSAEERSPKPAPWPYQEKGFNLFNYLYDKTTARLDENSKIIVVEGPPAAGKSKLAKQLAAEFEMLYLPEANLDMEYINSYGFDLRKLDSEIPESCRSWDVMDFLKNPKHRHTLRFQMQQYQVKLSQYVDALAHVLSTGQGVILDRCVYSDFVFTEAMFSQNYLHKLARKTYYELRDNTIGELLRPHLVIYLDTPVPKVIENIKKRAISYEKDSTVLTPQYLGVIEKQYKQNYLKDISKHAELLVYDWSEEGDVEIVVEDIERIDFNRYDEQDSYMKDWVYRLEEEWAVLRHKYADKKDPEIMAYCNIPAYNVPELVIEAEDADKYHKAMAEAPGQEYEIGYNAALGDTGLLFKMRSPHRETLPLRERRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FY79</accession>
    <name>A0A6P7FY79_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="5">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114332214</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028137773.1">
        <property type="nucleotide sequence ID" value="XM_028281972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FY79"/>
    <dbReference type="FunCoup" id="A0A6P7FY79">
        <property type="interactions" value="1535"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281972.2">
        <property type="protein sequence ID" value="XP_028137773.1"/>
        <property type="gene ID" value="LOC114332214"/>
    </dbReference>
    <dbReference type="GeneID" id="114332214"/>
    <dbReference type="KEGG" id="dvv:114332214"/>
    <dbReference type="InParanoid" id="A0A6P7FY79"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028137773.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41546" checksum="706B93FA56B2C49E" modified="2020-12-02" version="1">MNKQPLQLVKSVKFLLTSINRHMSSQTNEVIVKDVNDKGVLVLNRPKALNALNLSMVETIKQVLKDWESKKSLVLIKSTGESFCAGGDVRAVAEAGLRGEKTLGQIFFKTEFSTNALIGSYKIPYVAFIDGIVMGGGAGLSVHGRYRVATERSLFAMPETQIGFFPDVGGSHFLPRLTGKLGWYLGLTGQRLKGSDILKAGIATHICDSKDLPQLEEALLNNCTTDADIQITLNKFAKKDVPPFSLEQVLDKIDDYFSAPTMEEIVAKLEKDDSKWAQETLAILRKMSPTSLKVSLKMLELGQHYNLDDCIHMEYNMCLTFLKNNDFFEGVRALLIDKDQKPNWKPKTLEEVTTKIVNEYFYDLPILKIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYQ5</accession>
    <name>A0A6P7FYQ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pupal cuticle protein C1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332361</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137948.1">
        <property type="nucleotide sequence ID" value="XM_028282147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282147.2">
        <property type="protein sequence ID" value="XP_028137948.1"/>
        <property type="gene ID" value="LOC114332361"/>
    </dbReference>
    <dbReference type="GeneID" id="114332361"/>
    <dbReference type="KEGG" id="dvv:114332361"/>
    <dbReference type="InParanoid" id="A0A6P7FYQ5"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028309626" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028137948.1"/>
        </source>
    </evidence>
    <sequence length="71" mass="7400" checksum="EF2C119FDD2EDDD5" modified="2020-12-02" version="1">MFKIFAFLFAVLALAFAAPKAQPVPQVLAAYSAPAVVSSYSYPYAAASYAAPVAYSAGYGSLAYSAPLAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1U7</accession>
    <name>A0A6P7G1U7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114333001</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138610.1">
        <property type="nucleotide sequence ID" value="XM_028282809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1U7"/>
    <dbReference type="FunCoup" id="A0A6P7G1U7">
        <property type="interactions" value="1079"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282809.2">
        <property type="protein sequence ID" value="XP_028138610.1"/>
        <property type="gene ID" value="LOC114333001"/>
    </dbReference>
    <dbReference type="GeneID" id="114333001"/>
    <dbReference type="KEGG" id="dvv:114333001"/>
    <dbReference type="InParanoid" id="A0A6P7G1U7"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028138610.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16778" checksum="7C9776692E9025CA" modified="2020-12-02" version="1">MSNHHNGARAGETEQMAQSQCLKVFIQRDYSEGTLVKFQNRFPQELEGRLERQAFETTVNRLNAFFAEAEKATCTTYCEGCLACLTAYLIYICKETHYEKCLKKVSKYIAEQNERVYEPRGLKLTDPSLRGLRVLEISCLDRPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3X8</accession>
    <name>A0A6P7G3X8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335653 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335653</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141722.1">
        <property type="nucleotide sequence ID" value="XM_028285921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3X8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655227.1">
        <property type="protein sequence ID" value="XP_050511184.1"/>
        <property type="gene ID" value="LOC126887623"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6631087at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028206705" evidence="2">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141722.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="27403" checksum="4F8E23A32C7C5A0E" modified="2020-12-02" version="1">MAKLLALSFGVLLQIIIINGEDDKKWVWGEGSKEGGRSFGLSDAASSRYEVYEDDRPFNNYPPNGFVNGPVPGPLPGPVINKPGSIYEGNNQLYGGGQGAFYPGDGHGPGVLTGPGVLTGPVEDGSYKEYDRCKCTERFNCNSPGISYGHCDAGKRYCCYSTKKGSIGGHVPSRPIHSPENGILVGPGGPVGGNYYPRPVSNFGGPIRPGGFGLGPRPVSGFSGQNVYGAENGVLVGPGGPSRPHFGLNPGFSPRSVVDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G603</accession>
    <name>A0A6P7G603_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Calcineurin B homologous protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114336280</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142422.1">
        <property type="nucleotide sequence ID" value="XM_028286621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G603"/>
    <dbReference type="FunCoup" id="A0A6P7G603">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644271.1">
        <property type="protein sequence ID" value="XP_050500228.1"/>
        <property type="gene ID" value="LOC126880426"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G603"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500228.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028142422.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22240" checksum="ADAE62E4C16FF102" modified="2020-12-02" version="1">MGNRSSLLLREEEIAQIQNETGFTPNQIERLYSRFTSLDRGDCGTLSRDDFLRIPELAINPLGERIVNSFFQGDDFNDRVNFRQFMQVLAHFIPIKKNKENRLNSREEKLRFAFKMYDLDNDNMISKDELLAILHMMVGTNISEEQLNSIAERTIVEADEDGDQMISFEEFCKALQRTDVEQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G611</accession>
    <name>A0A6P7G611_DIAVI</name>
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        <submittedName>
            <fullName evidence="5">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114336289</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028286631.1"/>
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        <property type="gene ID" value="LOC114336289"/>
    </dbReference>
    <dbReference type="GeneID" id="114336289"/>
    <dbReference type="KEGG" id="dvv:114336289"/>
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    <dbReference type="OrthoDB" id="2021138at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="400"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028142432.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="66131" checksum="37A8888ED46AE98D" modified="2020-12-02" version="1">MSRSHNEKHFCILSKRKKHYTKPLHPAAGILAKLYVKYKHLIILDLNSTMAKEHYTHASVMRAELRRHANGPYNYIIHPFSKLNAVLERLFFLLLLHRTVFVVYAKLKSPNIFISCLVRDAFHVFIMLCFFFTGYTDKKTREVCTEHCSVIKHYLTTYFIVDLYLAIEEYIKILRYELVTLFVMCVSLLSYIIRFRSINYILHNTLVALKINKTFCFILSQTAILAFILHILTSLAYWVPTHWYNHFQNYPNDSWISQRNISFKKYDVFTYIDSYSLVVAYFTGTNCFDVVTQPIEQLIFVIYTFTGRLYILVIIAKVLIFFGYSDVSESQYENLYYQLSNYIRAMKVPAQIKKTLFERLDYTYQKKYFNEQEILSTFTEQIKSELFLFGGRNLIAKNPLLNSLDKFQLSKLFINMKSHLFSPEEIILDFDDIQPYVFFVSTGSIAGYTLEGIQWTHLGDGEVFGCIRLHPSAQRLYNPLYLSLETTEVYYIHYKELRWALQNKIQDAFKYFEIVRKERLKKYTKCRGFKGKMETTLNQLRKGEILEKQRLRHGPMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6P0</accession>
    <name>A0A6P7G6P0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide-binding protein subunit gamma-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114338332</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144724.1">
        <property type="nucleotide sequence ID" value="XM_028288923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6P0"/>
    <dbReference type="FunCoup" id="A0A6P7G6P0">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288923.2">
        <property type="protein sequence ID" value="XP_028144724.1"/>
        <property type="gene ID" value="LOC114338332"/>
    </dbReference>
    <dbReference type="GeneID" id="114338332"/>
    <dbReference type="KEGG" id="dvv:114338332"/>
    <dbReference type="CTD" id="35881"/>
    <dbReference type="InParanoid" id="A0A6P7G6P0"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="9">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028144724.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="8109" checksum="5D1F45C91CE4AF29" modified="2020-12-02" version="1">MDMVVSNLQQQRSVTEQLRREAAVKRMPVSMAVKDIIKYITEHEQDDCLLVGFSSQRVNPFREKTPCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G870</accession>
    <name>A0A6P7G870_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114334834</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028140740.1">
        <property type="nucleotide sequence ID" value="XM_028284939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507813.1">
        <property type="nucleotide sequence ID" value="XM_050651856.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507814.1">
        <property type="nucleotide sequence ID" value="XM_050651857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G870"/>
    <dbReference type="EnsemblMetazoa" id="XM_050651856.1">
        <property type="protein sequence ID" value="XP_050507813.1"/>
        <property type="gene ID" value="LOC114334834"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651857.1">
        <property type="protein sequence ID" value="XP_050507814.1"/>
        <property type="gene ID" value="LOC114334834"/>
    </dbReference>
    <dbReference type="GeneID" id="114334834"/>
    <dbReference type="KEGG" id="dvv:114334834"/>
    <dbReference type="InParanoid" id="A0A6P7G870"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028140740.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43333" checksum="3978489962E212A9" modified="2020-12-02" version="1">MESAIKSSDNSDLIVAKTVAMLVLGLASFCLGLLPIKLTKVISIKTVNGDKNLTISLLLCFGGGVLLFTTFLHLQPEVRQGFQHLERAGYVSTIGPGIPLAELVFCVGFFFVYLIEEIVHLYLDRRHSHINNNNALHKSLAVRKSSKQEVTIPRVSLIKIDDGNISCISTSNKDLLNSQITVNLEKAQPEFHQHNHHQHNHFDDTSKASFGGFLVVIALSFHAIFEGLAVGLEGSVEKVWYLFAAIATHKLVIAFCVGMELVTSQTRTLLVFLYIGTFAVVTPLGIGAGIILSEKDSTEDVTSIVLQGMAAGTLLYVVFFEVLAREKNNNHSGFWQLLAIWAGFACMFVLQVMIGHGHDHNHEHKDHHHRTTHQESQYSFQDTAILTTVPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCA3</accession>
    <name>A0A6P7GCA3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">glucuronosyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.223</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC114340457</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1-&gt;4)-beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16221"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:12574"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:132104"/>
            <dbReference type="EC" id="2.4.1.223"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.223" evidence="19"/>
    <dbReference type="RefSeq" id="XP_028147006.1">
        <property type="nucleotide sequence ID" value="XM_028291205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCA3"/>
    <dbReference type="FunCoup" id="A0A6P7GCA3">
        <property type="interactions" value="1424"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291205.1">
        <property type="protein sequence ID" value="XP_028147006.1"/>
        <property type="gene ID" value="LOC114340457"/>
    </dbReference>
    <dbReference type="GeneID" id="114340457"/>
    <dbReference type="KEGG" id="dvv:114340457"/>
    <dbReference type="CTD" id="37198"/>
    <dbReference type="InParanoid" id="A0A6P7GCA3"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001888">
        <property type="term" value="F:glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000033">
        <property type="entry name" value="Exostosin-like glycosyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF4">
        <property type="entry name" value="EXOSTOSIN LIKE GLYCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="22">
        <location>
            <begin position="194"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="23">
        <location>
            <begin position="680"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_028147006.1"/>
        </source>
    </evidence>
    <sequence length="937" mass="107040" checksum="38D9B6CE76A9F784" modified="2020-12-02" version="1">MVVLNGDSSRDICSWLVHVKLSRIVIILLSILILTPLITHFYLSKVERNSYYIEHNAHSHEDLPEDIYTFKEDDLKVGVEELLRIRGSVLSELRDIERKRQQYKMEIQTYVKNIDELKQELTHQQTNLNRLKISVEQAQVAQREALQQNTPDLALPKKLTADVLPEVLPPVSRYVSKRCRMFSCFDHSRCSLTSGFPVYLYDPDQFPVMHDGWDVDGFLKTTLKQTLGYNPHLTNDPKQACIFLVLVGEALKDTDDVSENVGNHLNLPPLDSDALKRLPYWGGDGRNHILLNLARRDLMSVSGDVFSGVDTGRAILVQSTFTYDLYRSGFDLIISPVLGPPGGDVWQECNPMLPARRDYLLTFQGEIKKQKSPSPRPSFDDSEDSNVELNRFILDHLVQLSKTTTSDKFLFEFECNPASDNNLNVANQDWALCGTDSSRRAVLKDSTFVLIFAPGQEDLISTTLLQARIYEALRSGAVPVILGGDQIKLAYDEVIQWKRAAVFLPRPRITELHFLLRAIPDEDVLLLRRQGRLIWERYLASVQSTLDTIVAVLRDRLNIPAAAADTVLALSVFNETFQPIQVSVASEVEQEESLGPLEPPFDSPTYRRNYSISLVQGPEIWNDWGDPFRLYPALPMDPLLSSDAKFIGSGRGFRPIGQGQGGSGKEFSEALGGNSPREQFTVLLLTYEREQVLLDSIARLRGLPYLNSVVVVWNSPRPPSPELRWPDIGAPVHVVKAARNSLNNRFLPLENLKTEAILSVDDDAHLRHDEILFGFRVWREHRDRIVGFPGRYHAWDLNTKSSWLYNSNYSCELSMVLTGAAFIHRHYLHLYWKWLPQAIRDKVDEYMNCEDIAMNFLVSHVTRKPPVKVTSRWTFRCPGCPQSLSEDDTHFQERHKCINFFTQVFGYTPLLNTQYRADSILFKTRIPHDKQKCFKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJQ9</accession>
    <name>A0A6P7GJQ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ubiquitin receptor ADRM1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114339022</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145448.1">
        <property type="nucleotide sequence ID" value="XM_028289647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJQ9"/>
    <dbReference type="FunCoup" id="A0A6P7GJQ9">
        <property type="interactions" value="1342"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655264.1">
        <property type="protein sequence ID" value="XP_050511221.1"/>
        <property type="gene ID" value="LOC126887649"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GJQ9"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="11">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="10">
        <location>
            <begin position="286"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028145448.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="44793" checksum="DB2669D236C21E52" modified="2020-12-02" version="1">MPAGGALFGSSAAGPGSTGGNKHLIEVRAGKMNLKGRTVNADKRKGLLYVYQSDDSLMHFCWQDRTTGIVEDDLIIFPDDCEYVKVPQCTTGRAYLLKFKSSNKKFFFWLQEPKTDKDEDNCKRINELLNNPSSAVQNTPNPDQDLQSLLNNMSQSQLMQLFGSGVGQIGGLSSLLGTIRGPNSGSARTSTTPAITHRTTVPTTPTPTPATNSQTSTTPAPGTTTPQNPIPTVTPDAPRVRGSTTRPQDESSPSSFPSSSPIQLADLQNFLSGLTPPPGAGAPAGGAQQAQSVDLSTALTSESLAGVLSNPETLQQLQNHLPAVDESTHEALRSTLASPQFHQAVSQFSSALESGQLGPIVSQLAVNPDAVAAAAQGNMADFVKALEKTSSQGEGAASENKDKDKSEKKDDKKKDDEDQMQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKN3</accession>
    <name>A0A6P7GKN3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC114343562</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150203.1">
        <property type="nucleotide sequence ID" value="XM_028294402.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150204.1">
        <property type="nucleotide sequence ID" value="XM_028294403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKN3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647170.1">
        <property type="protein sequence ID" value="XP_050503127.1"/>
        <property type="gene ID" value="LOC126882303"/>
    </dbReference>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028150203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028150204.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16774" checksum="6AF7760D031DFC08" modified="2020-12-02" version="1">MADRLTQLQDCINKQAEHFCNSIGILQQFASPSKFPNFDRSGSQTPQQQQNQEDYVQLFTTLIARCAKDIDTLIESLPSEESSTELQLQSLRILEQENQEAAERLEAVVRNGQELLEKIQAALSDIAQAQLDMQHLTKTIAQIENKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GN60</accession>
    <name>A0A6P7GN60_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apolipoprotein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114340093</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146623.1">
        <property type="nucleotide sequence ID" value="XM_028290822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GN60"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654964.1">
        <property type="protein sequence ID" value="XP_050510921.1"/>
        <property type="gene ID" value="LOC126887433"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GN60"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028557309" evidence="3">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="37"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028146623.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20729" checksum="D56D247C763C858B" modified="2020-12-02" version="1">MKKMSILVAILCMFVVNAHGHIPRASCPDVKGVLNFDPSKFVGLWYEQQRYPTILENNGKCVSTKYSLNSDESIGINTRYLNAESNEWTILEGVGVSDSTTGEAKFTVTYKNPALTAPFWILDIDYDQFFIPYSCIIQDGHVVENLYIQTRSLNPSNDVINAALKVINDNNLDATLLLHTDKTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNL1</accession>
    <name>A0A6P7GNL1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114344589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114344589</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151219.1">
        <property type="nucleotide sequence ID" value="XM_028295418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNL1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028295418.2">
        <property type="protein sequence ID" value="XP_028151219.1"/>
        <property type="gene ID" value="LOC114344589"/>
    </dbReference>
    <dbReference type="GeneID" id="114344589"/>
    <dbReference type="KEGG" id="dvv:114344589"/>
    <dbReference type="InParanoid" id="A0A6P7GNL1"/>
    <dbReference type="OrthoDB" id="6732782at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028151219.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="19222" checksum="BB166C21C22BCDC9" modified="2020-12-02" version="1">MSGIPSQLVIVTEDPVSIPIQTALIIMRELNVFGVKDISLEKDRIFIMLSYTPNSKHLKRKFGNLPIRYMRTKIQSEEEFQKVEEAVKGYRFNLLDDEYEEFEKQQQIQTNSGIKRTLYIQGTDHQSANKKSKPSTSTSSTAVVELQDEDDDYEDIEHFITQRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQ81</accession>
    <name>A0A6P7GQ81_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114340787</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147358.1">
        <property type="nucleotide sequence ID" value="XM_028291557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQ81"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291557.2">
        <property type="protein sequence ID" value="XP_028147358.1"/>
        <property type="gene ID" value="LOC114340787"/>
    </dbReference>
    <dbReference type="GeneID" id="114340787"/>
    <dbReference type="KEGG" id="dvv:114340787"/>
    <dbReference type="InParanoid" id="A0A6P7GQ81"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028147358.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52890" checksum="D5E1A27D1393DCC4" modified="2020-12-02" version="1">MIDKHVESTNKNVSNSDLNEKNEEETVWPQILAILAGGLGAFTDGVIFSWTSPFIVKIVQNKVDYDISEEEAANFPIIQPVALIITGFLISNLCDMIGRKKVLLFLAVPHVINLLLSAFGRHIYVFYAARVFAGIGDAFLWSALPMYIGEVASPKVRGVWGNTLASGLYMGQFAINVVGSYCDIPTTSYIFLPLPILFFVIFLFMPESPYYYLMKKDYEAAKSSLKFLTRKNNVDPEFNQLKHDVERQLSESGTWKDLVSIQSNRKALLAGFFLRWSQQFCGIPVFNQYTQFIFQKAGGLVSPRVASMIFSALCLILNIIVVTFVIDKFSRKRLYAFSLVPCSVVLFVISIYFYLDQMVPSVDTASLSWLPITALVSYQVVTSFGVTVIPTLMLGELFSSSVKAKGLTVLMIAMAGGVFMTSGIFNLLNTSVGYYAPFLFFGVCTVLSSISSFFVIPDTKGKTLEEIQMTLKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTT8</accession>
    <name>A0A6P7GTT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCCIP homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114342837</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149447.1">
        <property type="nucleotide sequence ID" value="XM_028293646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTT8"/>
    <dbReference type="FunCoup" id="A0A6P7GTT8">
        <property type="interactions" value="1968"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293646.2">
        <property type="protein sequence ID" value="XP_028149447.1"/>
        <property type="gene ID" value="LOC114342837"/>
    </dbReference>
    <dbReference type="GeneID" id="114342837"/>
    <dbReference type="KEGG" id="dvv:114342837"/>
    <dbReference type="InParanoid" id="A0A6P7GTT8"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028149447.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31920" checksum="8A42249633C9F145" modified="2020-12-02" version="1">MAGPKKKSRVPSKSESEGSSNDESDSGTYHGQKEIQATFEGRNPEVQDFHGIKQLLSQLFLKAHIDLSQMSDLLISQHGVGSVLKQSYGDSDDEDEDVEMSDEKDVFGIASVINLGSHKETPCVQQFFSLLEELSKKHADEAIQTEIRKIVTEHSRLGFLVNERFVNIPAQISVPMLNSLSEEVDRMKKKDPSYDFEYYVMICKTCRSKDNKDEVIFTNDEEEIFSTDADIGFEFCVANESDVGLGGRWLAEDKQVIPYRKVIMFKASKLKNIISKIALFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVM8</accession>
    <name>A0A6P7GVM8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114347024</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153559.1">
        <property type="nucleotide sequence ID" value="XM_028297758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050658203.1">
        <property type="protein sequence ID" value="XP_050514160.1"/>
        <property type="gene ID" value="LOC126889687"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GVM8"/>
    <dbReference type="OrthoDB" id="6696619at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028153559.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53117" checksum="6E75EB9C2E32F76D" modified="2020-12-02" version="1">MEQRYQVVYKSVGENIDGKLLLKKEDGPQRKNRTFLYLSAVIANLFVFSVSSLFSWSSPAIEKLTSNSSDINPLGEPITAVQESWIASLLQLGAAIGPLLFGKISDIIGRKKTLLVMAVPNVICLLTICYARSITIFYICRFMNGLVTGMAFAITPVYLSEIAEVHNRGAISNLMTFFMNSGVLFSFLLGPFCSLKLLTFFCALPSILFIILFGMFIPESPKFLVSVHKEDEAKEGLKKLRMTKDVNDEFKAILASIGASKHQKGALEIFKDARSRKALIITIGLMFTCQCSGVNSVISYLDTIFKVSGSTLPLYFLTNAVAVIQVVGNCISVVLIEKLGRRLLILTSAVCVLMTEITLAAYFYLRDVQHYNMDAISWLPAGSTIAFIFAISLGVSPLPFTIVGEIFPQSTKASGAALGCCVLFIFSFAVTFTFRVFMSLYGIAICFSLNTCFVFCGMLFIYFVLPETKGKTDSEIQKLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H232</accession>
    <name>A0A6P7H232_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">CDC42 small effector protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC114343498</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150135.1">
        <property type="nucleotide sequence ID" value="XM_028294334.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150136.1">
        <property type="nucleotide sequence ID" value="XM_028294335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H232"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657570.1">
        <property type="protein sequence ID" value="XP_050513527.1"/>
        <property type="gene ID" value="LOC126889338"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657571.1">
        <property type="protein sequence ID" value="XP_050513528.1"/>
        <property type="gene ID" value="LOC126889338"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5559822at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000004">
        <property type="entry name" value="CDC42 small effector protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF6">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028150135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028150136.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="9042" checksum="5E953CE39A022E10" modified="2020-12-02" version="1">MAAINELRVTLFSCCIPQPPKRKHHIDRSMIGYPTNFQHTGHVGSRDVEMPGEQLIALQNQMKSKGGYETPYKEPDWCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGA8</accession>
    <name>A0ABM5IGA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein stoned-B-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Stoned B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132124.2">
        <property type="nucleotide sequence ID" value="XM_028276323.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276323.2">
        <property type="protein sequence ID" value="XP_028132124.2"/>
        <property type="gene ID" value="LOC114327651"/>
    </dbReference>
    <dbReference type="GeneID" id="114327651"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012320">
        <property type="entry name" value="SHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51070">
        <property type="entry name" value="SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHD" evidence="6">
        <location>
            <begin position="1555"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="1733"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="977"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1069"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1435"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2047"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1437"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2055"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2068"/>
            <end position="2078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132124.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2090" mass="231135" checksum="1882415E75E13D11" modified="2025-10-08" version="1">MHKITKGLKKKKKGKKSKKGEEELFKPEELENYRKEHQGTSEEPAAKNEEWKNFLALTSGVDDILKKTQGDLDRIKSTSFFQRKPTESEVRKVEEEKLAQEQKAEEAKRELEPPTPSQLGIVEVSESESEEDEDDNIFDTTYIEALEAADLKLAYIPESPTLPNDGDDPFDTSAAEKAILGPEFERKGKKLVPLGAAVEVLTGRVQLPTCATKRPTPNKRQILKEQDLLLQSFDESAPVPAVAADEPQEIQKTLLDDDSIPLPEEPIDLSNPIPFPQAVAPVKVADTQIKQEIDNKKNIISEFDVISKLDDEDDLEFEALAAESLSRPIVANQSFPVGTGSVVPENIKWGAFGDELKEEDEDVLADDPFDTTFAEIVVPDFNREIVTTGVSLKTNSTNGKNFADPISRVPETGLNLIKPEDRDLLGGSNSDLATSVSISTPAFKPVTEIKVDNESDDEFDPRADEEPRSRTVSRPDVLNITSSKTVSFDLPSPDLNTLNTEAKIIKPLTPFYTRKVSIAEAPASEDPFDTSFASNVTPGKIELRLIENELFDPNLEKKLSINDNSFNPRDEAQTKIDKVVNTIKEISKPKPPSTSESIDIDLLAIDNDIPVKVLTPGASIEQTEELSYCDPFDTSIASNILPGRVELKLIESELIPSVPNSNTIVKRDLLIHDADEVIEKPLSPSAEVSSTVSFDTFDENYDPFDTSCALDIQPGRAELKVLESEFIHNAANPFLFNEEPYVSPNSGSNPFLLDDQGSDSMGFANDNPFLSQTATTISTTNPFSFDPMELEPAEAEVPVVQQFPNTTPFSATESIITESVVTAPPEMPKKPSDLDLKYSLQANANGPPRPPPPRPPPSKETQDLLMSVMGAMDATSSSLLGKIPPTRSPSPVNMRDLHSPSPTPEPTVRDLLDVNDKPPENVQPPQETTQPHTTDLFSLNDDNTCDINQNPAVGFGQDHFIQNQPFIHNEPLIQNKPLIHNEPPVQNPVKPPPPRPCPPVRPPKPPLPAPLIQKKEEPVVQNIEDIDMFGVEEPPRKKEVTKDDILNLYNAPKQEPVKDLLSDLMETEIPAQPDMTTPSTETVEGNKGFSPINQTPDAKDNLTPSEQNQDDLQMDLSDSQSKGSISSFTLNPFAPSEDLNGQKVDEESRNVEQNTMEINENINNTNFSTDNSGLQDDIFGATDQQTNSTQFGDMNFGFSDTSVTKEPAHTEANIFGTQLPNTNTADFSNTYTSPDSFGKANDPNIFGTAPATNENATGAFDAINNSGVDIFGGSNTTTDSFGTANNIFGTTTTTSDTFGALNQNSNAFGAANAATDSFGAANNIFGSTTTSTDSFGVTNANSNAFGSSHAIGDAYSPANVSADPFGGSEKQANAFGDRSDDFDDFAKKFDSAKVDDSAFGGGAWGNEFVNTNDTSVGFGQDDGFDAFLALQEPPMVPQSTPNKISKAASQESDEDKDFSVFIRPKGANDISGDVLPIIAPPPPTVAATFGDTFPRFNPFDQSEVPATIQNEVPFPAPTTEFKRTDSQETPPTPLFDEDMSMPLEPFPRIHYPEEGWEMHLRQPNKKKITGQRFWKKIFVKLQHQSDCVLLQLYNLKDDKDPFQELPLQPCYSVSDIGAQQYDQFGKIFTVKLQYIFYKERPGVRPGQVKKAERITNKLSQFAAYAIQGDYQGVKEFGSDLKKLGLPVEHAPQVSQLMKLGSLNYEDLKQFSVCIEEALFKLQAHRDRALHYKMEEVQITAVDELYVEQEADGHIVKQIARVRLFFLGFLTGMPDVELGVNDMRRQGKEVVGRHDIIPVVTEEWIRLEDVEFHSCIQQEDYNQTHIIKFKPPDACYIELMRFRVRPPKNRELPLQLKAQICVTGYKVELRADVLVPGFASRKLGQIPCEDVMIRFPIPECWIYLFRVEKHFRYGSVKSAHRRTGKIKGIERILGTMETLQENLIEVTSGQAKYEHQHRAIVWRCPRLPKEGQGAYTTHNMVCKIALTSYDQMPEKLAEYAYVEFTMPATQVSHMTCRSVSLQNSDSDEPPEKYVRYLARHEYRVGIEHTEGDSPNAYASATYVSKTTPAPAPPAQPAQPAPVAEESSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILL3</accession>
    <name>A0ABM5ILL3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135760.2">
        <property type="nucleotide sequence ID" value="XM_028279959.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279959.2">
        <property type="protein sequence ID" value="XP_028135760.2"/>
        <property type="gene ID" value="LOC114330571"/>
    </dbReference>
    <dbReference type="GeneID" id="114330571"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045941266" evidence="2">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135760.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="247" mass="25995" checksum="7E92CFF7C0F16718" modified="2025-10-08" version="1">MKNLILATVVLFAVYQAVDGIVCSHIYCSLVSCEQNITCKHYEILVEKGSFCGCCDSCYEKLYEGQSCWRLLEITSTGKCGLGLECNSEGKCAPVLPDFSVLPDFSVPPDAPVLPDAPVQPDALVLPDAPVLPDAPVLPDPPVLLDAPVLPDAPVLPDAPDLPDAPVLPDAPVLPDEPVLPNESVQPDESVQPDAPVLPDVSVLSDSPDLPDALVLPDAPHLPDAPILPDAPGLSDAHDGSILLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRN3</accession>
    <name>A0ABM5IRN3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">ATP-binding cassette sub-family B member 6</fullName>
            <ecNumber evidence="30">7.6.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">ABC-type heme transporter ABCB6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="44 45">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="44" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66768"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167478"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66769"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:66681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:19262"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58687"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:61361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61336"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:61337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167480"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:66773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66776"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167479"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:66777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Melanosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.5" evidence="30"/>
    <dbReference type="RefSeq" id="XP_028139808.2">
        <property type="nucleotide sequence ID" value="XM_028284007.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284007.2">
        <property type="protein sequence ID" value="XP_028139808.2"/>
        <property type="gene ID" value="LOC114334008"/>
    </dbReference>
    <dbReference type="GeneID" id="114334008"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18581">
        <property type="entry name" value="ABC_6TM_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032410">
        <property type="entry name" value="ABCB6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16185">
        <property type="entry name" value="MTABC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0967">Endosome</keyword>
    <keyword evidence="23" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="27" id="KW-0458">Lysosome</keyword>
    <keyword evidence="25 41" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0964">Secreted</keyword>
    <keyword evidence="21" id="KW-1278">Translocase</keyword>
    <keyword evidence="15 41" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22 41" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="41">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="43">
        <location>
            <begin position="253"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="42">
        <location>
            <begin position="579"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00024320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00024385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00024439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00031413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139808.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="833" mass="95367" checksum="26DA537104672301" modified="2025-10-08" version="1">MLNISYCPPNISVWDVWVDHGIPQCFMNTVTSSVLAIYILIAGSIQLHIYRRWGVESGTRFLPRGRLYYLQTFLILFIPVLEIVRFILTATVYDDKHIYGYMIVSLVLTTFAFPFSLWVLKVELYNILPSVQTRGHGIVLLLFWTLAFISENLAFINLTQENWWFKLKDLTDQLEMALFILRYIACLLIFFLGLKAPGIVNEVDYYMLGGHQRNVINPNNENASTWKNFWKKVKILAPFLWPKKNFTLQFKVLICFILLLGGRAVNLFVPIYQKLIVDSMEETVAKMLFRWDWVLIYVGLKFLQGGGTGGMGLLNNVRSFLWIRVQQYTTREVEVELFRHLHSLSLKWHLGRKTGEVLRVMDRGTDSINNLLNYIIFSIFPTIVDIIVAIVFFVSAFNIWFGLIVFTTMILYIVLTIVITEWRTKFQRRMNLADNETRSRSVDSLLNFETVKYYGAENYEVDAFREAVLKFQDEEFKSSITLNILNTVQNVIICGGLLAGSLLCVYMVVEPKTLKAGDYVLFATYIVQLYVPLNWFGTYYRAIQKNFVDMENMFDLLREEQEIIDAPGATNLSVPRGHVEFKNVSFGYLPEKLILKNITFSVPSGKTVALVGPSGSGKSTIIRLLFRFYDVDTGVIVIDGQNIKTVTQESLRRAIGVVPQDTVLFNNTVEYNIQYGRLTATVTDVIEAARGADIHEKILTFPEAYETKVGERGLRLSGGEKQRVAIARTLLKAPNIILLDEATSALDTQTERNIQESLNRMCANKTTIIVAHRLSTIIHADEILVLQEGEIVERGKHDHLIGQEGIYANMWRQQLENKDKESLENSSESAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISM6</accession>
    <name>A0ABM5ISM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zasp-like motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140735.2">
        <property type="nucleotide sequence ID" value="XM_028284934.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284934.2">
        <property type="protein sequence ID" value="XP_028140735.2"/>
        <property type="gene ID" value="LOC114334831"/>
    </dbReference>
    <dbReference type="GeneID" id="114334831"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140735.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="569" mass="64933" checksum="CE5344C2B4EA3716" modified="2025-10-08" version="1">MARLVNKQFNSPIGLYSQQNIQDVLDRESHLLENGAVGIDFNNPDVGKPKNLQNSAVLRMLEEEENRQRNGYGPGSDRLLKPLRAWPPPEYEQKSQLRSSFKDVVIPGVKRVAWPPPHETGQNSPYIEQNPVQTQGGPQYPSQAAGYQNNYQQPKPAPSNQALYQQQRAPLKLDVSQGGSSPLASPLSNQSPQAYRAPTPNKNWASVQSPVHTPNQPAWRQSSPSRFQAAHQPVSQQQFLGQQYSGPSQPNYSPNQGSQQYQPPVNQYQPQQQYQQPQNQYQQPQQQYQAPQQQYQAPQQQYQAPQQQYQAPQQQYQAPQQQYQAPQQQYQPPQQQYQPPQNQYQPQQSQNQFSSVAAQAVPYQYPSEQQYQTQSTQQYQYSQQYQSSEQSHQSQPQGYQSVPQTSQVHSVPIQVQRQTSKPVEPPPSTITLRPQAPVSQAPPPVYTSQPATATLKVYVNPKNLRGDLKWPPEDVKQKMYEEAENLNTSNSFLSIQGGKHLRGDMKWPPENVKVQAEEENRLRLELAKGPVCRPRKVHRDYTEFFDQHALNSSYPGYKIPPGTQFYRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXB4</accession>
    <name>A0ABM5IXB4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SIAH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146802.2">
        <property type="nucleotide sequence ID" value="XM_028291001.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291001.2">
        <property type="protein sequence ID" value="XP_028146802.2"/>
        <property type="gene ID" value="LOC114340409"/>
    </dbReference>
    <dbReference type="GeneID" id="114340409"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146802.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="527" mass="61098" checksum="309067A4BC7215BB" modified="2025-10-08" version="1">MAFIIPDKVLESLICTFCHKYLSVKPTRVYPNRDVKCGRCAMADKRKKQRASVESLYGKIAEKFLFKCINRFDGCRELLAYSQVRDHEEVCLEIIHKCPICYEEVTSLMMLRHFHSNHKDAILDFPAFVFNLSHYLETTGIYIYQEEDNLFFLYISYSKSENTIKLELVYMGSDKLASNIYHKFTVTSVNKEFDINCKSKPSCANACTIVDVSNMLHLINVKFKLIYQNLQFFTIPENVHSSNIENSLENLNQNLKDLTVSENVNSSSSSTNNSLEEPKPNQDKVQFICESPFEYTTRIVELSSEYNPQCFNCKEICTFSLSDTDAPEYYYSPTHNDFLCFCCFVWLTHENKIKENHLYLKKLMISNFLGRFCKWNCGQHFKFSQIISHEVFCAKRNHYYNCPVQNCSTKGFASALRKHLETEHRFSVCTSIIQLANTTMNHFVFLEDQIVRFKLECKFIGGDSYCGIPSRYEYKIECEIITNDNEIESEWKPHVLCFSGNTFKPLSGLPLSSSPSACKAKIVLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXX3</accession>
    <name>A0ABM5IXX3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148035.2">
        <property type="nucleotide sequence ID" value="XM_028292234.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292234.2">
        <property type="protein sequence ID" value="XP_028148035.2"/>
        <property type="gene ID" value="LOC114341436"/>
    </dbReference>
    <dbReference type="GeneID" id="114341436"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148035.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24148" checksum="2ED560280DBD30E7" modified="2025-10-08" version="1">MTSTKIRSRLLESLTLTLEETYNIAISMEMAELNSQVYASQNPTLSALPGNYQFESQRSPTNSELVTVTAATNSTANSSRSGHKYFFCGGPIHPRKNCPARESICKSCNKKGHFAKVCRSKSTSASTNVSEGYDNCTACILAATPASLKKAIVPAFIKGLRGDALIDTGSSVSFVNEDFANICKLPRKPCTQTVSMASLSHSSQVKGVKIFKLVITPTTTLTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGV9</accession>
    <name>A0ABM5JGV9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497171.1">
        <property type="nucleotide sequence ID" value="XM_050641214.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641214.1">
        <property type="protein sequence ID" value="XP_050497171.1"/>
        <property type="gene ID" value="LOC126878470"/>
    </dbReference>
    <dbReference type="GeneID" id="126878470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="377"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="811" mass="92918" checksum="DCCA0FA32A92EDBA" modified="2025-10-08" version="1">MKPYVKIDYSFIGNLSKMLLYFSVYAILQCVTVSASGSVDKRALQKSHEKSQQEKWADAFLNRNQLERQLDLVMLLKQITVDYLSDCTPIILFDTFTEKKDNLLLEKLLTSFPIAYMHGQITEDYEVNLFTNIDDMQPTCLSYLLFMKDVMKSKEVIGEQNNAKVIVIARSSQWRVFEFLSHEESRYFVNLLVIVQSERIMAANEEAPYILYTHKLYIDALGSSKPVVLSSFQDGNLTRKVDLFPKKFSDGFSGHRFIVAMSNQPPFVIFKGGRSNEGEKIFEGIEVRLVNLLSKFYNFTTDYREATEDSDVGSSEAVTRTVMRKKANIGIGGIYVTPDKMDRMGLTRWHSRDCAAFISLASTALPRYRAILGPFNWTVWIALIFIYLGGIFPLAFSDKLTLRHLIKNPEEMENMFWYVFGTFTNCFTFSGKGSWSKADKVTTKLLIGFYWIFTIIITSCYTGSIIAFVTLPVFPSVVDTARQLLSGWYQIGVLDKGEWQYLFLNSSDDVSAKLLKSLDLVPTIEEGLKNTTRYSLWKYAFLGSRAQLDYIVRTNMSTRSKRSVLHISKECFVPFSVSLAYPLKAVYGDVLSNGIELIQESGIMSKIKSDVEWEMMRSATGKLLAASSGGGLKALSYEDKALSLEDTQGMFLLLGIGFVMAGIALVFEWFGGCYKICQRKNRRGSDESIESNPRTHARQTNRIKFNFQEHYSKIKRSFEDYTHDDYTHDKDYTHDKDTNDGRDVSNENSEKKSEPKHEDSEFCVKDNQIDNIIDEIFDNALKEANTERRQFEFVRQSDQSYSSFVRLLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIC4</accession>
    <name>A0ABM5JIC4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497691.1">
        <property type="nucleotide sequence ID" value="XM_050641734.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641734.1">
        <property type="protein sequence ID" value="XP_050497691.1"/>
        <property type="gene ID" value="LOC126878824"/>
    </dbReference>
    <dbReference type="GeneID" id="126878824"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="135" mass="16676" checksum="24FC096204361F04" modified="2025-10-08" version="1">MVNTRSSKVEKEMDTSGPPAWFLKMKENEEKRRQEEKENEEKRRQEGKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKEEDKKLRKEEEERRRQAEVEIMNSLSQIHEHFQLELLMSNPNKQPFPLPSLIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIU2</accession>
    <name>A0ABM5JIU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497859.1">
        <property type="nucleotide sequence ID" value="XM_050641902.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641902.1">
        <property type="protein sequence ID" value="XP_050497859.1"/>
        <property type="gene ID" value="LOC126879020"/>
    </dbReference>
    <dbReference type="GeneID" id="126879020"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="798" mass="92427" checksum="133C29D55D53D6C9" modified="2025-10-08" version="1">MFGVERINKCVECGNVYKRKHDLKRHVNSSHPDKLDAIAPLKVLKGNVYKCAHCDKQFRHKQSLNFHVKKMHTNVSISAETKTLQHKCSLCDYHATFKKDFIKHYETSHSIPMQYDTIEFSNHDDFISWKNKIELETNASFVVETGKKAGIMNYICHRSGYFTSKGKGERHLKTHGSVKINGYCPAMIKEVAQSDGKYLAHFTKTHVGHQNAIGRLFLPSSERKTIAAKLAAKIPFEAVLDGVRDGISDTDKFQRKHLLTKKDLYNIEASFNLRSTTVRHRDDAVSLESWVNEMKTSCVLFYKPQDITLDEYPQLHSDDFILIIMNTGQLTTLKKFGSDCICVDGTHGVNSYQFELHTLLVLDDLRQGFPCCFCICSRSDETIMSLFFNCIKKESGPIEARVFMSDMADVYYNAWSKVMGETHFRLYCTWHVDRAWRKNLTLIKTKEKQELVYKTLRVLLQETDPSAFEPMLQSFVQKTLNDPSTVDFGHYFESNYSSKAMSWAYCYRMHAGLNTNMHLERMHGTIKYIYFQGKNNKRLDKAVNVLMKFVRDKLFDRLIILNKGKLSSKIVELRRRHKTSLDLDMSRIINLEDTWQIPSSTKAEIYIINENDIQCECQLICTDCKVRIHKYSCSCIDSAIAWNMCKHVHLLCRYRQLDQSGTKELSQEEQKMEIVEDHKAVESEIIFEEMDNKSASRCKTLAEKKEEMLRHLYVVVNGVTTVEEWKAVEKMVNPIEPTLTAIRQQTISNFESKDSKPSNSQILKQRRLFSTKKKRNKKKMVTKPTSEECDAIAINLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKR8</accession>
    <name>A0ABM5JKR8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein attachment factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498534.1">
        <property type="nucleotide sequence ID" value="XM_050642577.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642577.1">
        <property type="protein sequence ID" value="XP_050498534.1"/>
        <property type="gene ID" value="LOC126879510"/>
    </dbReference>
    <dbReference type="GeneID" id="126879510"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042422">
        <property type="entry name" value="CC103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031733">
        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein attachment factor N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="72" mass="8546" checksum="D30465EEA1113E49" modified="2025-10-08" version="1">MSSKQADIYRELQSCIQDDKMYWLKNDAKLRAVVTSKSYDEFKDYVAAAHLSPITRKEMTERKPVNWNKSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JL33</accession>
    <name>A0ABM5JL33_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498652.1">
        <property type="nucleotide sequence ID" value="XM_050642695.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642695.1">
        <property type="protein sequence ID" value="XP_050498652.1"/>
        <property type="gene ID" value="LOC126879542"/>
    </dbReference>
    <dbReference type="GeneID" id="126879542"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17316" checksum="0887D0F717126CE4" modified="2025-10-08" version="1">MELNSDGRGNPPDRGRIDDVASNMDYEVNEKQKQSEEIINININTQSKQVPITNPKNFLPDYQIFVLAVTLAGDSIDVAGQVLIKHFNILKSEVSDVLISKYIKELSVVFVELRPQLSVPGYFDINRRLLPMIFSTISTYAIIYIQIYYDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM00</accession>
    <name>A0ABM5JM00_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498969.1">
        <property type="nucleotide sequence ID" value="XM_050643012.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643012.1">
        <property type="protein sequence ID" value="XP_050498969.1"/>
        <property type="gene ID" value="LOC114340575"/>
    </dbReference>
    <dbReference type="GeneID" id="114340575"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="317" mass="36512" checksum="92A153FFA12F594C" modified="2025-10-08" version="1">MSLKMYNGVKIPIIGLGTWQSINEDELEATLDTALTIGYRHIDTAAVYHNEKCIGKVLRKWFDSGKLKREDIFITTKLGPEQTHPDLVESALNDSLEKLHLEYVDLYLVHFPIHMKLIDPLKPWHMLDTDYLEVWKKMEEQVDCKRARTIGISNFSIEQMERIMKNSRIKPANTQVELQVYFQQKELREYCRKNNIVVVSYSSLGSPGAPDFFKKIGRTVPVPNILGDPVVSAIAKKHKRTPSQIILSYLTQNDIVVIPKTVKPERLQENFDILDIILDSDDLTALENLDKGTSGRIFDMTHINPKIKEHAHYPFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM83</accession>
    <name>A0ABM5JM83_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499047.1">
        <property type="nucleotide sequence ID" value="XM_050643090.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643090.1">
        <property type="protein sequence ID" value="XP_050499047.1"/>
        <property type="gene ID" value="LOC126879817"/>
    </dbReference>
    <dbReference type="GeneID" id="126879817"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="43"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="270" mass="29022" checksum="37A455E5485F3198" modified="2025-10-08" version="1">MGKNQFSFVTAKGCNFFNVHICTKSNAGKPAAENSEKSSDLEIIDGQEVVPHSMPYMAAIRTVINSTSILCGGSLISDSLVLTAARCVDGASEVDVTLGAHNLEDNEDSQITLISSSFFIHKDYRHSGLADDIAVIELPVSVPLSRYIATIKLPELTDIGNTYEGQEALVAGWGGVNDVEQVKSNVLRYQNLTIIPVEMCEISYLFKMQSDQICASAPLGKNICLGDNGSPLVVNGVQIGIASYGSVFGCSMGFPGVFTRVTKYLEWLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JME4</accession>
    <name>A0ABM5JME4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499112.1">
        <property type="nucleotide sequence ID" value="XM_050643155.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643155.1">
        <property type="protein sequence ID" value="XP_050499112.1"/>
        <property type="gene ID" value="LOC114336001"/>
    </dbReference>
    <dbReference type="GeneID" id="114336001"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047512866" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="40"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="619" mass="68696" checksum="BBA2A82013A996D3" modified="2025-10-08" version="1">MDTNNICAADTCPGNLANASASLLFALLNTLTAAKCALASPDDYPQDYGPSLKDGDEFDFIVVGSGSGGSVVANQLSQNPDWRILVLEAGGIPSSNSDIPALLFTVQLSEEDWQYKTQPTEGPKGSCLGLINKQCNWPRGKMLGGSSAMNAMVYIKGNKNDYDQWAQLGNPGWDWESVKDYFTELENVQPPEDKVTPLGTKGLLPITKVRHNSPLRKSMNQGFNELGVPFLDEQNPENPIGAVDTPICVHNGIRANTGRKILGAVKTRKNLFVSIHSMVHKVIINKETKAATGVEVKIGDRLIRLRATKEVIVSAGGINSPQLLMLSGIGPKQHLTDLGIETIKDLPVGKNLQDHLMFISYDVKFDVNAIVPIDLIDAIYEYFRHKTGPLSNTGLTNYLNFVNPRNDSIWPSISYHNLLLYPNDEMTFFMAYRTHNVPDELIKEKIKACRDKPCLSHMAVLLNPVSRGELLLNTTNVYDHPLLYSGYFTDEADEDMQVMVDSIRFSDKLFFETEALKVHNPELVRPIAPACDVFEYRSDDYWKCVLRHFSITIYHPTSTCAMGPDEKTAVVDPRLRVHGIKNLRVVDASIMPRVVSGNTHAPTMMIGFKAAIMIKEDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVY2</accession>
    <name>A0ABM5JVY2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502098.1">
        <property type="nucleotide sequence ID" value="XM_050646141.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646141.1">
        <property type="protein sequence ID" value="XP_050502098.1"/>
        <property type="gene ID" value="LOC114324775"/>
    </dbReference>
    <dbReference type="GeneID" id="114324775"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF450">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="667" mass="77599" checksum="85C11DD19B43FF4D" modified="2025-10-08" version="1">MECNENNKDSRNQEVLTGIKEEGLNNIEVKLELDKNSYGQESVDEYCSNSDDIKIENHEFVDVSNEIKAEIKTELEDYSIGTPPDITIEVAITKPFNAPKLHLKTCTGKRSYECEICSKLFTTKGAPPDITMEVAITKPFNAPKLHLKTCTGKISYECEICSKLFTTKSILKIHMRRHTGETPYKCEICNKQFTQISNLNTHMTVHSGKKAYKCEICSKLFTFKSSLKQHMRLHTDETPYKCEMCNKQFTQTGHLKEHMRLHTDETPICEICSKQFTQIGHLKEHMRLHTDETPICEICSKLFTTKSSLKRHMRLHTGETPYKCEICSKQFTQIGHLNSHIMRLHTGENPYKCDICNKQFTQLNNINDQMVVHTGERPYKCEICSKQFTLKGNLKQRMRLHTDETPYKCEICSKLFNTKGSLKMHMRLHTGETPYKCEICRKQFTQKGHLIEHMRLHTGETPYKCEICSKLFNTKGNLKVHMRLHTGETPYKCEICSKQFTQIGHLNSHMRLHTDETPYKCEICSKLFTTKWILKMHMRLHTGETPYKCEICCKQFTQIGHLNSHMRLHTDETPYKCEICSKLFTTNGSLKRHMKVHTGETPYKCEICNKQFNQLSNLNTHMRVHSKTAKPYKCEICGKQFITRSKLNNHMRIHHHHPASSLVHCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYA4</accession>
    <name>A0ABM5JYA4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502921.1">
        <property type="nucleotide sequence ID" value="XM_050646964.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646964.1">
        <property type="protein sequence ID" value="XP_050502921.1"/>
        <property type="gene ID" value="LOC114325629"/>
    </dbReference>
    <dbReference type="GeneID" id="114325629"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="387" mass="45457" checksum="393A179527A41018" modified="2025-10-08" version="1">METEQETSEELCKIETDNEVFDGHLDVFKIEIKEEPKTENENHEFDYLNLHEFPVKAELEQVEYKFTLFEEKQETNEESRFQEENRMNVIDQHPEGKILNKNVIVATGQRHSICEICSKQFIKKSHLKTHLRTHTGEKPYQCDICLKQFSVAGSLTRHIRGHTGEKPYKCETCFKEFVESGSLKKHLTVHNGQKSYKCEICLKEFTQSGSLKGHLREHTGETPYKCEICFKKFTQLRSLKKHLRVHTEETPHKCEICFKNFSESGHLTRHLRLHTGETPYKCEICLKQFSVADNLTRHMRSHTGEKPYKCETCFKKFTESGSLKKHLRVHTKQKPHKCEICFKQFSQKGHLKIHLRVHTGEKPYKCGICFKLFIQASHLKSHLRTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYT9</accession>
    <name>A0ABM5JYT9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503107.1">
        <property type="nucleotide sequence ID" value="XM_050647150.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503108.1">
        <property type="nucleotide sequence ID" value="XM_050647151.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647150.1">
        <property type="protein sequence ID" value="XP_050503107.1"/>
        <property type="gene ID" value="LOC126882291"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647151.1">
        <property type="protein sequence ID" value="XP_050503108.1"/>
        <property type="gene ID" value="LOC126882291"/>
    </dbReference>
    <dbReference type="GeneID" id="126882291"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="749" mass="87949" checksum="4A73E2AFA751D25F" modified="2025-10-08" version="1">MCFVYFLQGKLNQKQEIMDYIYQSTTSRSLQSTSTSSEFVSGACHLCSKIFKNVKLRNRHIKRIHKIDVSIKKIDHIVCPLCEQETSLQTHENLRKHIKENHQVSIELITLEFSSKQEYETWKDMQKIETSYATSRTVNAKEHKILYYECNRSDTYGYKPHSKIRTEKSGGSIRIKGVCPSRLICKLTNQGQVSVSYWKTHAGHKEELRAIHLSKAEEKTIEEKLMAGVPPSRILQDSRKFEKPQLDRLALLTSQDLANLSKKYNVHKKRDQNDMVATTLKVQEWNANNKNYAFLFKKEGEEHDVLRKEDFAIGFMNKIMEDKLRKFPKIICMDGTHGTNKRQMDLTIMLVKDDRNAGFPVAFLLSNRLDQQVQEVFLDALKNKMKTEIQAEHFMSDDENKYYNAWVKIMGNEPNRLLCTWHVVKNWNIQGKKKFHDPTLKKEMKTELRQIITETDVDTFNELCRNYLIKLQNANETEFFDYLREYYLKDLKRIKMWAHCYRRNSGINTNMAIESLNNLLKTNYLKRNGRVGIEKLLDTIDELVETKMWKRIVDMKRPNANNYQDRTIMKSHRGAERNKKKMKVTKNVAVYGQYQVTSLKDPSLLQNVTLSQVCESECKLLFCRVCKICMHRYQCDCTVYEVKNTLCQHVHLVRMYEESVGTNSVLDDAARCLGESSIIKSNHEEEINEFIREKLEQTNETQEKTKGSLELQNEIKNEMEALKNEMEALKNEMEDLDDTSLTKLRDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ02</accession>
    <name>A0ABM5JZ02_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 4C1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503171.1">
        <property type="nucleotide sequence ID" value="XM_050647214.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503172.1">
        <property type="nucleotide sequence ID" value="XM_050647215.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503173.1">
        <property type="nucleotide sequence ID" value="XM_050647216.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647214.1">
        <property type="protein sequence ID" value="XP_050503171.1"/>
        <property type="gene ID" value="LOC126882335"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647215.1">
        <property type="protein sequence ID" value="XP_050503172.1"/>
        <property type="gene ID" value="LOC126882335"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647216.1">
        <property type="protein sequence ID" value="XP_050503173.1"/>
        <property type="gene ID" value="LOC126882335"/>
    </dbReference>
    <dbReference type="GeneID" id="126882335"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="58012" checksum="8B9C9A756C0E20F2" modified="2025-10-08" version="1">MYLLVLCGVVILIWYLQFLWQNRRLYWYSYKTPGPIGLPFIGIAYKFLTRDISVILQRVIDIQTSYPQVATIWFGPRLYYLVSKPEYIEKILTSRSALNKDHVYQFMSDVGEGLVTVGAKKWRTHRKTIIPSFNQKILEAYQDIFWNKAEQFTIVLQKEVENKKVPMLKLVSHCTMDIVCATTLGLNMNIQNSEEVEFITALEKLMEIISVRMLHVWHQLRFTWRLYPMSREFDKAFKIAKDFSSTLIANTKRKYESTRGNSSFEDDIALAVQGKHRDGISFLDLIYKNTKFTEQEITDEINTFLIAATDTTASGLCSIFTMLGMFQDIQQKVFEELIDILGPDRRAFPDDLPQLKYLERVVKESLRLFPPVPLIGRTLHEDIDGGDMIFPSRSSVIFGAVFIHRNPVYWPDPLKFDPDRFLPENTAKRHPCSYIPFSYGPRNCIGAKYAMMNMKTVLSAVLRKYKIFTEYKSVEEIKLSTSLILRLRDGPKVWIELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K032</accession>
    <name>A0ABM5K032_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503546.1">
        <property type="nucleotide sequence ID" value="XM_050647589.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647589.1">
        <property type="protein sequence ID" value="XP_050503546.1"/>
        <property type="gene ID" value="LOC126882616"/>
    </dbReference>
    <dbReference type="GeneID" id="126882616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25717" checksum="FB15D793B62D4B08" modified="2025-10-08" version="1">MDALKREIGTCKSSFERNVNWISNFLESQTDTFELSHRRTHLINAFNNYNDICNKIDTHKNADMHTENREEVENKHFSAMSRIDGKLAQFSKVNSSPSVPSQYQHGNHANFNVRLPPVSVPIYHGEPSKWVSFYQLFSSIIKDNQTLTKAQKLIYLKSSLRGEPLNLIDSLDVTNENFDLAIDILERKYDNCLAIINSHINLIIDFPTLTRSNYRSLVILQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K039</accession>
    <name>A0ABM5K039_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503552.1">
        <property type="nucleotide sequence ID" value="XM_050647595.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647595.1">
        <property type="protein sequence ID" value="XP_050503552.1"/>
        <property type="gene ID" value="LOC126882621"/>
    </dbReference>
    <dbReference type="GeneID" id="126882621"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="43276" checksum="65FA86D9559FC71C" modified="2025-10-08" version="1">MERNIEIQKYNLEAKIYEERRKTEEKFDDMLQNIQTNNHHIRNVEQRIEDISQIRDIGRPYLNLTNETGIKFSGNIKNLHPRVYINSLKHKLRSVNNINDIKDYIRMTLSDNAATWFASIENDLDNLQTFENKFLNYYWGELEQARFREVLYFGKYNRNLSLNMVDYALKLITVAKYLEPPLREDETVLNVSRHFDADVVQTVTVQNIQTVDSFINFIQRVQRGYITSNNSKNRQSYNNNRYGSNSQNFNNNNNTSYERQGNRENFNNNTNDNRQERQGNRENFNNNNNYNRQDFNTRRNAQRYNYNRQVNYVRGQSCEDSQRNSTWQENMNSRSESSERHRELDPNDQTQSDNPNNPNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0B4</accession>
    <name>A0ABM5K0B4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503631.1">
        <property type="nucleotide sequence ID" value="XM_050647674.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647674.1">
        <property type="protein sequence ID" value="XP_050503631.1"/>
        <property type="gene ID" value="LOC126882695"/>
    </dbReference>
    <dbReference type="GeneID" id="126882695"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="476" mass="54771" checksum="394FC2A764AF6C3B" modified="2025-10-08" version="1">MDYAGRPPDKPPDINRMDQDDNIEKSDININNTWDGKSKNKGETVSNKSDNSTDNIREHFLYQSSDVGPFHAYIENNTPNFKGQLNAIKIGDIILSNFSNLDNKITSIDSIGKNRIRIKFKDYQSANFLINQKACSLFTNNNLDVYVPKFILHRQGIIRDIDIEFSEEYIKNKIKQYDMHCKFEVVSVRRINRKVEKHIEDKTIIDKVPTKSCIFNFKAQTLPKYITINKVIKDVEPYVQKVLLCFSCLRFGHIGFNCKARPRCNKCHDFHNTKDCTVNEYTPTCFSCQGNHLTTHLSSCPEFSGQKQIKNTMSSLNLNFFDACKQIPKISYANIAARNSSSSLPTNSNQNEQSYQVIPNQSASSSKKFSSQMFLSSNNPEKINFKRHRPSSPNPLESARKEILSQENIPRQKGGIYNTSKYTEHTNTTNLQTQGVPSQLNNVVREYEKRKWIRNPFILEVNDGFDLTINDRENLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2S4</accession>
    <name>A0ABM5K2S4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504493.1">
        <property type="nucleotide sequence ID" value="XM_050648536.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648536.1">
        <property type="protein sequence ID" value="XP_050504493.1"/>
        <property type="gene ID" value="LOC114330370"/>
    </dbReference>
    <dbReference type="GeneID" id="114330370"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="866" mass="101146" checksum="8C690D9F1F0E36A2" modified="2025-10-08" version="1">MDDDTCEHHPRYLNQIKAKSVSQPGDEKYTTSTLIRDELEYASNYRAVQKRIPRKEVYPKNRPFELPFELCRLKQLQKRKKKKGDHVEKLTKKPTMLERSIMSQDEYMRWLAMPNIKKKGSDPKPKKVKRCQMSPCPPRCVQLSAPPKRRVLSTWTEYQDKLPAEVLLRFQQMLHTDQNLKLRDADYYYKKIDKRKRRLAKRKKRLRLKRKLNKERGKYAWIGENISDTTRAILEYLRQEPLYSLNYKQLLLSDQILNILDEKNVLSKPSRTSKNTYQKCFIETSDKLAVWMDTLTKFVDVQAVESAEDIPPITISTLIPEEEEEEEEIEEEVEEVEEGEDEFITEEEEEYEESVKVEYEDGRDIEKEYEQEEIAEERDHIGEIEAEDGEEGMIYDKEEFEKRTAEVDEKIDHLESGEEGEADFDDKKESGIIEPGEKEKLSEEVIDLGPLDIGEEFGEEYIGKLPDDHEKDKYEEMDLDLLKALIQIYEERSPSDYLRNQVQHFPGYTYEEILKKMKDITLEKEGPKKSKLEEAMIQWLRDVAPDQVNERNLKAIHEYACALLAELKKRGWSEEDIDKLGPFIEGEDAGIDVVKEIEEIIREGESEGQKQIDTLYPIGEEDFEQMEISEGEGKIAVDTGIVRVDSKDKDKELGEYIYGHKPSVVRDHCLDAICCLTLKIWAVWLLEVIHNAHTWTKWMHEIIGSVRSYASVVRGDVKDANGKTKVLLKSDWEKFVKETEKKVIAWRQYSAHVNDLSNEIIENFRNKEVYCCPKCLQDHLIKNVVTAHNTFAALTEAMNCAQYWRRCLDDLVETTASITVPEDKEQVGSSSSSEESLEADEIEELSIESSDSDDDESIYELEEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3Y6</accession>
    <name>A0ABM5K3Y6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 58 central coiled coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504896.1">
        <property type="nucleotide sequence ID" value="XM_050648939.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648939.1">
        <property type="protein sequence ID" value="XP_050504896.1"/>
        <property type="gene ID" value="LOC114325265"/>
    </dbReference>
    <dbReference type="GeneID" id="114325265"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049270">
        <property type="entry name" value="CFAP58_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21771">
        <property type="entry name" value="CFAP58_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 58 central coiled coil" evidence="4">
        <location>
            <begin position="382"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="128"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="253"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="498"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="890" mass="104675" checksum="1B5687AAF6D3A0AC" modified="2025-10-08" version="1">MEDSDFEGDEFHSEEERPAEVLDPENPEHFFPIVERDFNKTIANLEQNPEALPFTEDFNKLFEAFFQTYSRQKELETLAEDMTSDLTDKAHKIELSLKLADEDQRTIIELRRQIENAWKLADAAHAREQLAHEIIDNLRRQVENLNAEIEFKNKMNQDTDETGELSKHKDGLERERDRLVNEVTQLTTKLQNAVTYQEELEKKNSEADMKINEIAGQLEDQTQETNRQKRFKEKLEGDIQDVKFKLDEKDIHIHELNETIKDLGKQIAVLHKDIKDWRYAHDKLSKELEATLMKLAKLTDEHNTSLFEVDAVKKALHEKSIDMKVLQDESTRYKNDLSKAQKARDLLEKRVLAIIKERDETTIDRNNLRQRIGIFEKEIEDFKKYIDEDKRTIETLGKEKDVLNKTIQRQQVVQKDHQKLIHIQEQSKKKLELELDLFFIESGKHKKLITQLERERDRLAEEQLDLTNTIQDQLEDIRQKKVFIFDLKKEASERDNKIRQQQNMYEAMRSDRNALQKLHQESTAEAGELKKKLRLVSHQIEQLKENIGQKEKQLIKDESIVRKLTKEKEQLKIEVMTGLDQIRVLRTDNKELHEEEKRLHKTLANLNRTIKEQAKDLEQLMNERDVLGSQLVRRNDEIALLNEKIVILQATLTRGETHYELRLDDIRLLKLEIKRLRQEKGHISKTMASMVELRQEVFHLERDLTRSRLKCKALEQEVQNPLNIHRWRKLAGSDPEVLDLLQKIQILQKRLLQQGSLAVERERQLKQAERLYLNLRKVVARQPGPGIQEELCKTQRALKSRGNKLKCMVSELNMADFKANEYKSDLQRVTEELADLKKKYLAEKKANRTLRMAYESSRELNQGRSSSGGTGEVKFTGGGFRMSVSQISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K414</accession>
    <name>A0ABM5K414_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine protease easter-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504927.1">
        <property type="nucleotide sequence ID" value="XM_050648970.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648970.1">
        <property type="protein sequence ID" value="XP_050504927.1"/>
        <property type="gene ID" value="LOC114333008"/>
    </dbReference>
    <dbReference type="GeneID" id="114333008"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046377668" description="Serine protease easter-like" evidence="8">
        <location>
            <begin position="19"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="48"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="10">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="431"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="77545" checksum="49E0E5E8C44183E4" modified="2025-10-08" version="1">MIAIIVIVVVVFLNLGNCNYTIDTHVNWRFVPNDICGTTKYDGHRSRIIGGKKSKVGEFPWLVRLGWNFLGFKYWNCGGTLITEKYVLTAGHCFYNDAVRVGPIDPGAECETSYCSEYQIRNVKKWVFNDYVKESMRYDIALILLDEPVQFTEFVKPACLPRKHLLYENLLGHHVDIAGWGYTDNNGNLPDSLMHINLPIIKKQTCELGYKKKLISSQLCIGKIGDSGQDSCNGDSGSGVTMKRALDGKTRHYLVGIVSHGFTQCATGPGIYTSVSHYVNKILDNITSLVISSFLNRLLMKDCDFCSCCDIKMRRSFGLLLVFLGLWTLCIAQTEYCMTPRQEGGDCKIITQCPSLFKILKNRPIRSEDADYLRKSQCGFEGTLPKVCCALQETVQTTTQRQVDYDTPKPADSPLLPSKEDCGIGSIPDKIYGGNTTDLDEFPWMALLDYEKDNGNHGFYCGGVLINSRYILTAAHCVKGKDLPRNWKLVGVRLGEYNLETDTDCVQTVSGQKCAPPPVNVAVEEQIAHEQYKPYDQNQYHDIALLRLARNVKITGFVRPICLPKTADDQSKNYTGKKLTVAGWGKTETRSESNIKLKLDVPVKANTECSRTYRQAGVQVNNGQLCAGGEKGKDSCRGDSGGPLMAYAADEEFQLNWFIIGVVSFGPSPCGMENWPGVYTKVANYVPWIVSKLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4E7</accession>
    <name>A0ABM5K4E7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoprotein hormone subunit beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505060.1">
        <property type="nucleotide sequence ID" value="XM_050649103.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505061.1">
        <property type="nucleotide sequence ID" value="XM_050649104.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649103.1">
        <property type="protein sequence ID" value="XP_050505060.1"/>
        <property type="gene ID" value="LOC114340578"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649104.1">
        <property type="protein sequence ID" value="XP_050505061.1"/>
        <property type="gene ID" value="LOC114340578"/>
    </dbReference>
    <dbReference type="GeneID" id="114340578"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF13">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028452" description="Glycoprotein hormone subunit beta domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="6">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="145" mass="16423" checksum="79002E0E9113E069" modified="2025-10-08" version="1">MLGIVLWLAVTWSLTTAVANNAHAVIKIELNPLAKRVVTLKCHKKQYIYTVIQSDENGKKCGDKISVDVCWGRCDSYEIPDWRFPFKISHHPVCIHSGRTEMFAVLRYCEDGVKAGTNYYEYVTATECKCQTCTTTDTNCNSFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4T5</accession>
    <name>A0ABM5K4T5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505200.1">
        <property type="nucleotide sequence ID" value="XM_050649243.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649243.1">
        <property type="protein sequence ID" value="XP_050505200.1"/>
        <property type="gene ID" value="LOC126883591"/>
    </dbReference>
    <dbReference type="GeneID" id="126883591"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="178" mass="20625" checksum="DDB323079BC0D9D0" modified="2025-10-08" version="1">MAQSPPIYEGSRKVGSNLFQELSSDTDDCSSMDENGFKKPRSERKKEKSKKKKEEKSKNDAEAKKDGENPIAEPMYDEAEQAVRGTTKRAKPKESEADENKKEKVLKTNEQEEMRKMLEAMTTERDQQRAENEKLRIVIQEQKEEMKKMSAQLNNLGARYKQNTIKDTPRKASYERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7J7</accession>
    <name>A0ABM5K7J7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506163.1">
        <property type="nucleotide sequence ID" value="XM_050650206.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650206.1">
        <property type="protein sequence ID" value="XP_050506163.1"/>
        <property type="gene ID" value="LOC126884269"/>
    </dbReference>
    <dbReference type="GeneID" id="126884269"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29754" checksum="770CA5A905427C2D" modified="2025-10-08" version="1">MNRCNPEPHFKIVETIEAGRSVLTVVPHKWIKNKILFWPPKNVKNLIKDVNSTPDITWNKIICRIKRNYYKNRIAAETELLEMSGGSATSSTDSEVLGEMKEKNKVRNTKKVTSQQNFETLFASSSSKFCSFQPIIPEETPEPVVESENIILETNFSDEAIISPEAIANAQFLNVIEQPLIGEESKNDIINKLNDIEQTFNQFKNDITESVKDMLVKAVAAIKSDFDAKLLSAMQNFKNNHQDDDNIQFEFHAVSTSQELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8G2</accession>
    <name>A0ABM5K8G2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506478.1">
        <property type="nucleotide sequence ID" value="XM_050650521.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650521.1">
        <property type="protein sequence ID" value="XP_050506478.1"/>
        <property type="gene ID" value="LOC126884561"/>
    </dbReference>
    <dbReference type="GeneID" id="126884561"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="333" mass="38755" checksum="40CB7D663ECC6439" modified="2025-10-08" version="1">MHCVDEAMVPYYGRHGCKQFIHNKPIRYGYKLWVGASRLGYVNWMEPYQGATTNISEKYIDYGVGPSVVLEYADVLRTRWPNKRMHLFFDNFFSTLSLLELLSEKNFNATGTIRENRISNGPLTNSKEIKKEARGVFDFKKTENQNIIVVKWHDNSIVTLCSNAVGVNPLHRVKRFSRKERTNIQVSQPHLINLYNANMGGVDRCDQNLSLYRISLRSKKWYFPLVAHCIDVALQNAWQLHRQRGGDLDQLRFRRRVATTLLLQNKKKETHSKGHKSSTEGLDIRFDRMDHLVIPQNKQTRCAHCHEKTTTRCSKCDKGLHVKCFLVYHTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAC2</accession>
    <name>A0ABM5KAC2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507141.1">
        <property type="nucleotide sequence ID" value="XM_050651184.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651184.1">
        <property type="protein sequence ID" value="XP_050507141.1"/>
        <property type="gene ID" value="LOC126884878"/>
    </dbReference>
    <dbReference type="GeneID" id="126884878"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17749" checksum="9A4729D726F7697D" modified="2025-10-08" version="1">MASKICTIRQIIIQIGELELLDIYRGKYSINTNKTVLFYMPHCLKQLTNNLLWANWGLNLGHCVVVSNSFHKIIESNSTRHVVECANYITKILPYVFEVAIINTFKYYEVFSDMAVHVFPKMNLVCPDAWENHQEPSYKQNDVEFVSKTVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBT8</accession>
    <name>A0ABM5KBT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507653.1">
        <property type="nucleotide sequence ID" value="XM_050651696.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651696.1">
        <property type="protein sequence ID" value="XP_050507653.1"/>
        <property type="gene ID" value="LOC126885231"/>
    </dbReference>
    <dbReference type="GeneID" id="126885231"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045159789" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="111" mass="12409" checksum="B424075B6A0F2C30" modified="2025-10-08" version="1">MKLVIFVTILALIGLVQPVYIPEEDESVQVPVEFPLECQACEAFAKLIGELVEKELPKDYVEKEAEKLCEKLGGSLKKFCLEHLVPVVDKIYDEIVKHTSAKGVCELLGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC77</accession>
    <name>A0ABM5KC77_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proton-coupled folate transporter-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507796.1">
        <property type="nucleotide sequence ID" value="XM_050651839.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651839.1">
        <property type="protein sequence ID" value="XP_050507796.1"/>
        <property type="gene ID" value="LOC126885316"/>
    </dbReference>
    <dbReference type="GeneID" id="126885316"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF37">
        <property type="entry name" value="GH08173P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56823" checksum="02038F7A903DFD3D" modified="2025-10-08" version="1">MKLQEYPELNKMDEPATTRYSNKFLHYFKYVTVEPTMLLYMMAFMTTNVAEQSFYVYKTCTINHGYNKTICDNINAPEYKNISKEVQASTAKFHVWNNIAGHVTPIILALFIGAWSDKRGRKLPLLIGLFGKLIFSLMIIVNTLQPSWPVEYVVFTATLPSALTGADVTIFATAFAYLVDVSSVSNRTMRVTILEVCYLASMPLGIAFGAYLFKFVFNRSYTYMFVVNSILMVLAILYTSLRLSWRSNSMQRPLSEASNKFLDFFDYNHAVSTFGMLSQYRPGNKRTYLWLLLIMMALYTFQRNERDIMLGYCYLTFHWNDGQYSIFKTIQSGLQDIILLLAIPIMSKIFKWRDTIIIMIGAIAHVMGRIFYSTAVDPYVFYIGGVFAAVGPIVAPVIRSLVSKTVSTSEKGKAFAVLAVADNAVPLIAGTSYNALYYFVLPYNPGYVFFLTIATQIGVFLLATYIHSRTHRNEFEIEIPPPKPILHTENDLLQEPNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDD4</accession>
    <name>A0ABM5KDD4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508198.1">
        <property type="nucleotide sequence ID" value="XM_050652241.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652241.1">
        <property type="protein sequence ID" value="XP_050508198.1"/>
        <property type="gene ID" value="LOC126885616"/>
    </dbReference>
    <dbReference type="GeneID" id="126885616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="131" mass="15747" checksum="04B64D44F648D4B7" modified="2025-10-08" version="1">MIGKGKWGNGARRVIVRCIVFQIPWKILRTQPVLHLSTDLMNDLRHYLQSTIVRGVSQIRLLKIARILLVFLLQKNRTERNMLHVNHVDTRKNGRTNKRRNRRDTSIYNRENELIFGAHKFSFNRYKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE44</accession>
    <name>A0ABM5KE44_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450 6a14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508452.1">
        <property type="nucleotide sequence ID" value="XM_050652495.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508460.1">
        <property type="nucleotide sequence ID" value="XM_050652503.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652495.1">
        <property type="protein sequence ID" value="XP_050508452.1"/>
        <property type="gene ID" value="LOC126885723"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652503.1">
        <property type="protein sequence ID" value="XP_050508460.1"/>
        <property type="gene ID" value="LOC126885723"/>
    </dbReference>
    <dbReference type="GeneID" id="126885723"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="56997" checksum="25B99B2486B34BAC" modified="2025-10-08" version="1">MDICILIYILLGLPLFVYLYQKWKYSFWRTRNVFHLEPKFPYGSAQSELKLNGAMTSIVEDLYHKVKARGLKYGGYFEFLTPMFVPVDLELIRCIMMKDFPHFTNHGTYVNEEVDPLTGHLFNLEDEKWKIIRAKLTPTFTSGKMKMMFQTMVECTEGLQELLKKSAASKEPVDIKSNLSCFTTDVIGSVAFGVDINSMKNPDSDFRKFGNRIFVHTTLVRLKFIFLSIWPQWMIKKSGIKLFSKDMEDFYLNLIGDTVEYREKNNIIRKDFLQLLIELKDSLTIKEMAAQSFAFYAAGFETSSTTMSFALLELSQRQDIQDQLREEILEAFKKDGDTMTYDSIMGMELLEKVISETLRKHPPAGILPRICNKTYKDPNSDLVIEAGTRINVPVYAIHRDPDYYPDPETFDPERFSEENKANRAPFSYMPFGEGPRTCIGMRFGKLQAKVGLCCVLRNYKVTLNEKTKLPITYRSGFVSAVEGGLWVNLEPLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEP4</accession>
    <name>A0ABM5KEP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calpain-A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508667.1">
        <property type="nucleotide sequence ID" value="XM_050652710.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652710.1">
        <property type="protein sequence ID" value="XP_050508667.1"/>
        <property type="gene ID" value="LOC114330442"/>
    </dbReference>
    <dbReference type="GeneID" id="114330442"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16196">
        <property type="entry name" value="EFh_PEF_CalpA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF433">
        <property type="entry name" value="CALPAIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="261"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="920"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116496" checksum="FF329389994896E0" modified="2025-10-08" version="1">MWESFYDRTSQSCSGINAKLLSYNKKKHDLQSVEYKNYIHRDVLCVLDPNPMKKHKSQKSKKGVPSASKRINNTGVLSAYVYHKVREEAADTKKRPVSSSCGKCETPSEVNAGAEKICEILPKSSIPRPRSSSNYSKTPTTELSSESPNKQASNELENSEKIKSKSSCRPICQFSKKPLSTLGNDGASLICVETLQIQPKLCTIKTCLRRERSRLVKLYESTTEKIKIYKFGEKGSGTRSKSGDSQDFYALRDECLANGTLFEDPEFPCNDSSLFFSQRPDRNYEWKRPNEICNDPKFFVEGFSRFDVQQGILGDCWLLAATANLTLNSRLFFQIVPDDQEFDDKYAGIFHFRFWQYGKWIDIVIDDRLPTYRGELVFLHSAEDNEFWSALLEKAYAKLNGSYETLKGGSTCEAMEDFTGGVSEMYEMESSPPNLFQIMVKAYERSSLMACSIEPDPRVLEAHTPQGLIRGHAYSITRIKYVEIHTPNVSGKIPLLRLRNPWGNEDEWNGAWSDEAPEWRYISQEEKEELGLTFDKDGEFWISFKDFMKYFSRLEICNLNPDSLSENELHETHKKKWEMSVFEGEWVRGVTAGGCRNFLDSFWHNPQYRVTLTDVDDDDDENKCTIIVALMQKNRRALRQSGAELLTVGFAIYHLKYPDRLPKPLDINFFKYNASVARSPSFVNLREVSCRFKLPPGTYCIVPSTFDPNEEGEFILRIFTEKQNVMEEHDEEVGYGEVDSKVAAPPTEEEKQEFSQVYQFFLKLAGEDKEVDWMELKDILDYSLKSDREQKKAIVSVEPKSTEKTASTEKDLTVEPEVKVVLPATPGQEVATTTVTNSTTTTETGHSFTSLCSLFCGTICQKTPLADYFTPKTNVAPLRSVLAELKLQGFSKDICRSMVAMLDADRSGKLGFQEFKELWGAIRQWKNVWLMYDTDKSGTFSGFELRDALNSAGFRLNNKVLNILMHRYGNKNGEMEFEDFMMCAIKLKSMMDHFKKKQQSGSNNATFSIDEWLESTLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG83</accession>
    <name>A0ABM5KG83_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509216.1">
        <property type="nucleotide sequence ID" value="XM_050653259.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653259.1">
        <property type="protein sequence ID" value="XP_050509216.1"/>
        <property type="gene ID" value="LOC126886367"/>
    </dbReference>
    <dbReference type="GeneID" id="126886367"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="273" mass="32298" checksum="A78A9594159212CD" modified="2025-10-08" version="1">MHLPKQWSRSSGRVLEITNEHLQKYAHLLKWRNNASILECGIATGENSLKSIIPILPQDYKEFVATDNSKNMLECAKDIINIPRSTVCELDVNARHPPLDMENRFDHIFGFFLIHMVDNPRQAFRNFHTMLKPGGSVFLNFFERIPVDGMFHNLRSHPKWGKYRQEDAISVYYYTQNPKEEYRKDIEAAGFKNYVYNNEIHRHVFKSEEECRDLHTSVNPIVHNIPKAEYDEYIEDYIKEKENTPSFVINYDNGKRTIYTDYKMFVFYATKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGD3</accession>
    <name>A0ABM5KGD3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509254.1">
        <property type="nucleotide sequence ID" value="XM_050653297.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653297.1">
        <property type="protein sequence ID" value="XP_050509254.1"/>
        <property type="gene ID" value="LOC114324452"/>
    </dbReference>
    <dbReference type="GeneID" id="114324452"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="381" mass="44087" checksum="8ABC3DF99CCFFEC8" modified="2025-10-08" version="1">MYSVIEFKQEEDGGGLSIVNSTWLTPRKTEVRWPPIKDNLQFKKVLRKLEPEIDETWKIYGVQKIFYSTDDFEKATNKLKRAEITSDLQTDLEDDNTRPRRKILKRKFSSDEDSNDQVSLFKPGKKSKQILPRPPPVGINKLYTNPRGSSQELESGTDKSDPGIPSGSQFMKSISTPRDKLSFQISTPKSSSSFGRQEATEIQTPTLNESLNFDNSLQDTNGLKVLLKHILTIKEQNRKILNILEKSKPFENSDLPDDFKIKLPIESLQDLEELEIYLTEEENFNTFKSYCASISNLKDVTQKNNRILRSLLTDNIAKHFNYFGNNRRQDRVSNKRPFNQLRLNKVVLDAVKQGTDFTTHEVENAIKRWLKHAPNRNKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGG1</accession>
    <name>A0ABM5KGG1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509284.1">
        <property type="nucleotide sequence ID" value="XM_050653327.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653327.1">
        <property type="protein sequence ID" value="XP_050509284.1"/>
        <property type="gene ID" value="LOC126886388"/>
    </dbReference>
    <dbReference type="GeneID" id="126886388"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411709" evidence="8">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="289" mass="32668" checksum="58F02B081B85E000" modified="2025-10-08" version="1">MKTLIFLVIIVSCISRSFQMTCDRTYAITICYQIHISKANPLLIDDYNSMLSISLDEQSDTIYTNAFIRLAELKRLILSNNKIKTLELGSFNGLSKLDLLSLYNNSLTTVDSSTFQNLHNLEILSLGSNQITSISNDGFLGLDKLEELKLSFNQLAEFPVQINTIKTLRKLDLNGNKIKSLKANSFSNLKKLEKLNLNDNLINSLEAKSFAGLSNLRELSLKSNYLKQFNTQDVLEDLGSLQRLNLAINDLKCADLKNIDNELQRKRITFEEGINKQNPSTFKGIKCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGU5</accession>
    <name>A0ABM5KGU5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500906.1">
        <property type="nucleotide sequence ID" value="XM_050644949.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506265.1">
        <property type="nucleotide sequence ID" value="XM_050650308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509426.1">
        <property type="nucleotide sequence ID" value="XM_050653469.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644949.1">
        <property type="protein sequence ID" value="XP_050500906.1"/>
        <property type="gene ID" value="LOC126880876"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650308.1">
        <property type="protein sequence ID" value="XP_050506265.1"/>
        <property type="gene ID" value="LOC126884390"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653469.1">
        <property type="protein sequence ID" value="XP_050509426.1"/>
        <property type="gene ID" value="LOC126886506"/>
    </dbReference>
    <dbReference type="GeneID" id="126880876"/>
    <dbReference type="GeneID" id="126884390"/>
    <dbReference type="GeneID" id="126886506"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="449"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="506" mass="58334" checksum="205731B5E1C91C68" modified="2025-10-08" version="1">MRAYKSLAAYKYFKSGFVEKVGFKVINDLVLLIGKVQHSMRARETKLRVWIIAETGGSICTAHCTCMAGLGEVCSHVTAVLYAAEHAAYLKQQKNEKNVACTDVKSTWPVPTQSGTHPIEAASLDWGKVIEEKNYKEIPPMDDSEMLDLLQELQNSNCDAVLMRHVEPFASQLSDENNEKVSIPVLFNVYHKKYEKMPLDDLIQLGMKCKMEVTQNIRREIEDKTQDQRKCAEWYRQRTGRVTASIFKDVCRTNVEKPSLSLIKSICYPRKISTRAIRWGINHEQLAIDAYKKETSRNHRDFIVNTIGLVVCMKWPQLGASPDGFVYCDCCAAGTLEEKCPFSLRENGNLQEYASRKDSCLECDKTGTVKMNKKHKYYYQVQAQIFICKLNYCDFVVWCPNFIFIERVLPDIKFWEEIKDKVLNFHAKVIMPELLGRYYTSRVPGGNITKWCFCNNVDDGQPMVQCSYENCNIFWFHIGCVNLLEKPKTRWTCSICNQKLFHDYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHT5</accession>
    <name>A0ABM5KHT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050509688.1">
        <property type="nucleotide sequence ID" value="XM_050653731.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653731.1">
        <property type="protein sequence ID" value="XP_050509688.1"/>
        <property type="gene ID" value="LOC114335981"/>
    </dbReference>
    <dbReference type="GeneID" id="114335981"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17264" checksum="E7B119A93A88816A" modified="2025-10-08" version="1">MDTSMCAKSGCYYEHIRWGEAFVIVYSIIDKHSFNEAKEILGELVKLKLPSYYASLLLGNKRDLDHSRKICIDDGHELSLKYGCQFYEVSAAEHFAGVSLAFHSLLKEARSVLLLRSLPIRRRLGVNSVSKVLGNIFGKNSKGDRKKRPSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJE9</accession>
    <name>A0ABM5KJE9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050510335.1">
        <property type="nucleotide sequence ID" value="XM_050654378.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654378.1">
        <property type="protein sequence ID" value="XP_050510335.1"/>
        <property type="gene ID" value="LOC126887056"/>
    </dbReference>
    <dbReference type="GeneID" id="126887056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01221">
        <property type="entry name" value="PH_ephexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11793">
        <property type="entry name" value="SH3_ephexin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047270">
        <property type="entry name" value="PH_ephexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="213"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="298" mass="35108" checksum="F023BB7BBD21B850" modified="2025-10-08" version="1">MLPMQRITRWPLLVDAILKRLSESDPEYLTCQYALATMNKTVTQCNEAARTKEQELELTKISESLVFDKDVPPIEINTQGRYIIRSGSLMCYQSRNEDTKMTFGRRFSKINLHIFLFNDLFVVSKKKSEFLYTVIHYCPRNFIELRSVDMFPGLRKKDVMDKNLLYLSVLENHHKKVVEFLLSALTETDKERWIEAFSPPKSENPDETLYECWDCPQVMAMHNYNGCQPDELSLSRGDVINVLRKMTDGWYHGERLRDGHTGWFPANYTVEIINPHVRARNLKQRYRLLTFSENYLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKE4</accession>
    <name>A0ABM5KKE4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510669.1">
        <property type="nucleotide sequence ID" value="XM_050654712.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654712.1">
        <property type="protein sequence ID" value="XP_050510669.1"/>
        <property type="gene ID" value="LOC126887297"/>
    </dbReference>
    <dbReference type="GeneID" id="126887297"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="235" mass="27491" checksum="44F8EA6453C3F0BD" modified="2025-10-08" version="1">MRKHTGDKPFGCQIWKKQFTKTTYLKVHMRMHTDEKPFECEICTKQFTQLSSLKVHMRTHIGEKPFGCQVCAKQFFTNNHLKRHNMVVHTGVKPFGCEICTKQFVTHNELKIHMVVHTGVKPFGCEICTKQFARSFDLKVHMRTHTGEKPFGCKICTKQFKRIADLKSHMNTHTSEKPFGCEICTKQFTQLSNLKVHMRMHIGEKHFGCQVCTKQFLRNDQLQRHMVVHTGVKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLW9</accession>
    <name>A0ABM5KLW9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050511195.1">
        <property type="nucleotide sequence ID" value="XM_050655238.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655238.1">
        <property type="protein sequence ID" value="XP_050511195.1"/>
        <property type="gene ID" value="LOC126887632"/>
    </dbReference>
    <dbReference type="GeneID" id="126887632"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="184" mass="20198" checksum="0973686EDD142292" modified="2025-10-08" version="1">MASIFNQTGSSLSGNTVGAIVGVFQMATYCVAAYLIEKCGRRILILTSSFTCVFPMFFLGLYFYLKRIGASIITNIGWFPVVCVIVFIICYGIGLGAIPVAIVGELFSSDLRAKGVGMTLVLDSLAVSFVVFCYPLVTKTFGIHICMWMFCFLCLLGCITLYFILPETKGKSFCEIQHLLSEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KN71</accession>
    <name>A0ABM5KN71_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511642.1">
        <property type="nucleotide sequence ID" value="XM_050655685.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655685.1">
        <property type="protein sequence ID" value="XP_050511642.1"/>
        <property type="gene ID" value="LOC114330848"/>
    </dbReference>
    <dbReference type="GeneID" id="114330848"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="333" mass="37974" checksum="47E0720F8AE96996" modified="2025-10-08" version="1">MVQKESQKVNLPWVEKYRPSTLDDLVSHEDIIKTVSKFIRDDQVPHLLFYGPPGTGKTSTVLACARQLYTPAQFPSMVLELNASDDRGIGIVRGHILTFASTGTIFKSGFKLIILDEADAMTMDAQNALRRIIEKYTENVRFCIICNYLSKIIPALQSRCTRFRFGPLSPEQILPRLNYVIDEERVSVTEDGKKALLTLANGDMRKVLNVLQSTWLAYKHVTEDNVYTCVGHPLRTDIESIVKWLLNEDFKTTYNNIKELNMIRGLALHDILTEVHKYVQRIEFPYDVMIDLVEKMGEIEYRLSAGANENIQLTDLISAFQNVKDIKAPDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KN97</accession>
    <name>A0ABM5KN97_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511665.1">
        <property type="nucleotide sequence ID" value="XM_050655708.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655708.1">
        <property type="protein sequence ID" value="XP_050511665.1"/>
        <property type="gene ID" value="LOC126887833"/>
    </dbReference>
    <dbReference type="GeneID" id="126887833"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39945">
        <property type="entry name" value="FI14129P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39945:SF1">
        <property type="entry name" value="FI14129P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047158356" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10076" checksum="D7C508C24413DCF8" modified="2025-10-08" version="1">MALHCEKNRILNIIIIIMMITYEISARPGNEWRQNNACQDGDATKREICQRCAKQTKSPLAYPMCCNEEDEVHKWCYRYTTYGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KU08</accession>
    <name>A0ABM5KU08_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AKH/HRTH/RPCH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513666.1">
        <property type="nucleotide sequence ID" value="XM_050657709.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657709.1">
        <property type="protein sequence ID" value="XP_050513666.1"/>
        <property type="gene ID" value="LOC126889418"/>
    </dbReference>
    <dbReference type="GeneID" id="126889418"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010475">
        <property type="entry name" value="AKH/RPCH_hormone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06377">
        <property type="entry name" value="Adipokin_hormo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="6" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="89" mass="10318" checksum="229A22AE4C52A3CE" modified="2025-10-08" version="1">MNQNNRKSNFYPIICCLLITWLFIYTSNAQLTFSKGWKIGKRTEDEPDSQIKISANAICHFLVSQIRQMSACNNNHPNNDLENIINEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUI9</accession>
    <name>A0ABM5KUI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513853.1">
        <property type="nucleotide sequence ID" value="XM_050657896.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657896.1">
        <property type="protein sequence ID" value="XP_050513853.1"/>
        <property type="gene ID" value="LOC126889545"/>
    </dbReference>
    <dbReference type="GeneID" id="126889545"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.40">
        <property type="entry name" value="ENT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033482">
        <property type="entry name" value="EMSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005491">
        <property type="entry name" value="ENT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036142">
        <property type="entry name" value="ENT_dom-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16500">
        <property type="entry name" value="BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16500:SF3">
        <property type="entry name" value="BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03735">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01191">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158639">
        <property type="entry name" value="ENT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51138">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENT" evidence="4">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="661" mass="73076" checksum="443B0A69B88AD5D4" modified="2025-10-08" version="1">MWPLLLDMTKEESVQNLRNLELEAYSQLVSALRAQGYPNPDKLKLLKDTGYLLNISLDRHKAEVRRAISDEKLNTIAYHITGHTASREDWAKEGQRLVPLLTREAPQTLYSLVANDASESASQCNKLLPPPASTERKRPVVSPVTALATPETSKIVPFMKQEENVSKKRKLMVPENANINQNVLGPKLCRIQQVYRQRTKLKPKEIVKKVDHDHSELGQHRMINPASIHSFSQSHTGLSSSPQPSQSQFMNQMNQRIHILQNISLQSVKEELPDEELTEGNNSDTPEHSTVPQVPLCSNENQAPKPKVITTVKPNASITVKQVSPQTPGPSTEPQKCIKITPKTPMTKTVNSGQKLIVVSNAQTIPSNSILQRTLQIPFVKNISIKKLDKFKIVTSNSTSTNLHLTNVTNSGVNSVKHKVVTVKTNPSTKKVIPLSQLQVMSSKGSIKVLPLGGKIVGKSVSGTSSPLYIVNTTQVSKSTTTPTVTTSKLQTEKSDVKLEESGAEIGSTASTTTTNCTRENGKSSVLEDILKASGVIAEENVAEDYDSKIEEFHISQHKVGCENVSQELVIKRDQLLEEIDKCESNVECTSITEDKIHDDCISNDIEQDIKVEEKMEFDVNEIAEFENSLSLTSHLSEEITTEEVPLDVLMDVEVSKISDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVF5</accession>
    <name>A0ABM5KVF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514169.1">
        <property type="nucleotide sequence ID" value="XM_050658212.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658212.1">
        <property type="protein sequence ID" value="XP_050514169.1"/>
        <property type="gene ID" value="LOC126889692"/>
    </dbReference>
    <dbReference type="GeneID" id="126889692"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047159504" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="189"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="461"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="584" mass="65691" checksum="8C2AFCB17926F948" modified="2025-10-08" version="1">MYRWCVRSLLFIFPLVLGDAPSVFEPEGVVPFIKFGSKNYYFSYRFKANFFQADQICKDINMILVAIPSKEVNDFLNTTISAANSKINFWTSGSNLVDKMSWMWMSNAQPITYSNWNHGQPSASANRCLLGQMVKGKDLLWMNEDCNALYNFVCESIEPAASSQTVGGGNWANSFADPAVSPNFPLFQYNNKNYYVNTQPLSFLDADRFCRMINMELVAVDSDAENTGLYTWLRNINMGTNFWTGGTNLINGIDWIWFPSGRKVTFTNWMKGQPDNIIERCIQLVVNKDMEQLSETIWWNGGMEWSNLGCEVTLPFICQSPTEKITRRPAAVAANENSKSLGVTETSDVISPPGISNQIVTTSESLTADWISNMDASETYDETSDVISTPDTSTQIETSPATITADWNSSMDESETYDETSDVISTPDISTQIVTSPETIIINGNSVEDTRDVISCPKIFYRILYNIKVSYDDAVKKCKKRGMSLVSIQSKEKSNSLNTVLQASSYGRNTFWTSGNKKYNKWTWLKGEPLEFTNWNAGEPNNGRGNEDCLTVTVFKSDNHSLWNDEPCGWGYTPVCEKVVECSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXA1</accession>
    <name>A0ABM5KXA1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BLOC-1-related complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507421.1">
        <property type="nucleotide sequence ID" value="XM_050651464.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514807.1">
        <property type="nucleotide sequence ID" value="XM_050658850.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651464.1">
        <property type="protein sequence ID" value="XP_050507421.1"/>
        <property type="gene ID" value="LOC126885036"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658850.1">
        <property type="protein sequence ID" value="XP_050514807.1"/>
        <property type="gene ID" value="LOC126890031"/>
    </dbReference>
    <dbReference type="GeneID" id="126885036"/>
    <dbReference type="GeneID" id="126890031"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38385" checksum="A5929090576E61CE" modified="2025-10-08" version="1">MFARLFQSCFPSAGEMDLDNILNFETLKCHTQCVSVGKRVLCEESEVPPSKKRRDVFSVDSSFVPPSVSGVRDSRKRAPSEESVIYVGSETLPLNQPRSEMGRLILKIKKNTAVAAQTFKVAAEVHASPSVQTSKHHSTSFEDISDSEDGTSDHPSLQTCNKPSIEGYPSIGDILNISELGSSPEEGLTQTHITQPQAEEEIPMKPMTETQVWEKELISRTEPSLTNVVTRVLQIPNRAEAYHQALCEDFKGGLVSALERHQDRIQERLNENLKESELLKKAIQNIFSYGEKISEAFHEENIRLSQDLINIKASLANAVRSDSRDLFNKNVAGDVLRCGMRDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXQ0</accession>
    <name>A0ABM5KXQ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514971.1">
        <property type="nucleotide sequence ID" value="XM_050659014.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659014.1">
        <property type="protein sequence ID" value="XP_050514971.1"/>
        <property type="gene ID" value="LOC126890161"/>
    </dbReference>
    <dbReference type="GeneID" id="126890161"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43598" checksum="E19A428ABC75D6A8" modified="2025-10-08" version="1">MDQIDEIDKAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSAQSTAKVRLPDITMQTFCGPFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSLLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFATHSTFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLKVSDHDKKVNNRSKSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQTPQNSQGASRVVAPISTQRSFNNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXW5</accession>
    <name>A0ABM5KXW5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515034.1">
        <property type="nucleotide sequence ID" value="XM_050659077.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659077.1">
        <property type="protein sequence ID" value="XP_050515034.1"/>
        <property type="gene ID" value="LOC126890223"/>
    </dbReference>
    <dbReference type="GeneID" id="126890223"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="228" mass="25016" checksum="2E5FD9E4F1D717A7" modified="2025-10-08" version="1">MFAGWEHKLQFGGIHFKPGYLVVDCETPQSAEWLRLKVPQIRKWEGGELTTCKGDDIPRSHVVTVFLPRSKGLSAEKLLQLIEVQNEGLAIGRWKVLSAKEEAAGQLLRAAIDELSYAALRKNGCTIFYRFGKIPVHGIKRETEKETPGSSGGLVTTEVEEAPPVPSASRGTDVPGDAESVGDHHSTDLYRDSEDMETAEATNVEEDKDKTLVGGEEGEKETSPQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYB9</accession>
    <name>A0ABM5KYB9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515177.1">
        <property type="nucleotide sequence ID" value="XM_050659220.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659220.1">
        <property type="protein sequence ID" value="XP_050515177.1"/>
        <property type="gene ID" value="LOC126890348"/>
    </dbReference>
    <dbReference type="GeneID" id="126890348"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03045">
        <property type="entry name" value="GST_N_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24996" checksum="5A0EE08DB9072A63" modified="2025-10-08" version="1">MLLLYQNGAPPSRAVQLVAEALSVKLTLKYVDVLTKEQFAPEFLKLNPQHTLPVLDDDGFILIDSHAIMSYLVSKYGKDDFLYPKKLQKRAIVDHRLHFDSNILNVRGAVIVKRVFLEKKRDIIPEQLKALEEAYEIVEKFIGSNKYVAGDELTIADFCFWTTITNWNAIGLCTEEKYPKITAWLKRMYELPYSKFNRDAEDEFKATWIQLMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYW4</accession>
    <name>A0ABM5KYW4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515380.1">
        <property type="nucleotide sequence ID" value="XM_050659423.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659423.1">
        <property type="protein sequence ID" value="XP_050515380.1"/>
        <property type="gene ID" value="LOC126890462"/>
    </dbReference>
    <dbReference type="GeneID" id="126890462"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="267" mass="30539" checksum="2F9CF31DC7828CEA" modified="2025-10-08" version="1">MSGSAIPLDEEGLVNMVEQYPQLWDQKCKEYKDRIAKENAWQSIAVILEARVKECQELWEYLRTKFIRERNKRNKIKTGSASQTNTWTLYDRMGFLAKGIQTRRTKSNILFQKTDHESSPWSEMVVDDEGILSSVPTENDSEVDEDILNESGQEGTSESDCVSLPKTTTQLPCTPKVTNEAIGNLRVEKNIKRKGNNEVSIDKLVNTCTSLGRNIEQILTNNDTDQEDYHFAMALMQELKKIPNNSEKIKLKASFFMQIADVVDKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ93</accession>
    <name>A0ABM5KZ93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket protein 28-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515507.1">
        <property type="nucleotide sequence ID" value="XM_050659550.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659550.1">
        <property type="protein sequence ID" value="XP_050515507.1"/>
        <property type="gene ID" value="LOC126890542"/>
    </dbReference>
    <dbReference type="GeneID" id="126890542"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="61709" checksum="134748A20FE84F12" modified="2025-10-08" version="1">MTEADITKSAPEDKLTSNLTLYFREYCQNSTIHGLKYLASNEKRMWYERLWWICSIALSLFLCISLIMSIYIKWENSPIIVSFATKETPIWQTPFPVLTICPETKATPNKFNYHKFLLLNRENESIDPENETKFGLLSLLCNYDENINIKSTFNGTPEDIIHFYEEVQPDFYKTISDCRFMGKRFNCRELFVPIFTEEGICYSFNMLDRHDIYREKVVHYKNFGSTFPTNWSLEHGYPIRDKRGTYPFRALFAGVVFALEAKLTVNESDLDYFCKSSIQGYKMEISHPSRVPRPKYDHIRIPLDQAIMATLILDMMSTSKAVKNYNPRRRNCYMPNERPLNYFKIYTQQNCKLECLTNYTLNKCGCTTAYMPRENITRICNGLDNHCVCLAEMDMLNASIDGHLLKLEGKQTSTECDCLPICSKMNYIIQSSQLNWNWAAEDSNYTKGKHMSMFQVFFKDNQFITSERNELFGPIDFVANLGGLLGLFIGFSMLSLIEIVYYITLRLIANFNIFGRKYWAGNTVKENIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0B1</accession>
    <name>A0ABM5L0B1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515876.1">
        <property type="nucleotide sequence ID" value="XM_050659919.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659919.1">
        <property type="protein sequence ID" value="XP_050515876.1"/>
        <property type="gene ID" value="LOC126890748"/>
    </dbReference>
    <dbReference type="GeneID" id="126890748"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22125">
        <property type="entry name" value="F-box_FBXL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047932">
        <property type="entry name" value="FBXL14_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="446" mass="49793" checksum="436CDED8729640DC" modified="2025-10-08" version="1">MMEDPTQVLFTELPVPLLSTAAFLRHHTRYQPYHLPHRFHIQEFVQQRTYEEEQTELDSGKTHISCLYPEILAIIFSYLDVRDKGRVAQVCTTWRDAAYHKSVWRGVEAKLHLRRGANPSLFPSLVRRGIKRVQVLSLRRSLRDVIQGIPNIESLNLSGCYNVADVGITHGFSAECPSLTQLNLSLCKQVTDNSLSRIAQYLKNLEVLELGGCCNVTNTGLVLIAWGLKKLKRLNLRSCWHVSDQGIGHLSFANQSLEYLGLQDCQRLSDEALKYAAALTSIKSINLSFCISITDSGLKHLAKMTNLRELNLRSCDNISDIGMAYLAEGGSRISSLDVSFCDKIGDQALVHISQGLFNLKSLSLSACQISDEGLAKISNTLHDLETLNIGQCSRVTDKGLTNIAEALTRLKCIDLYGCTRITTVGLEKVMKLPQLSVLNLGLWHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L127</accession>
    <name>A0ABM5L127_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516143.1">
        <property type="nucleotide sequence ID" value="XM_050660186.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660186.1">
        <property type="protein sequence ID" value="XP_050516143.1"/>
        <property type="gene ID" value="LOC126891004"/>
    </dbReference>
    <dbReference type="GeneID" id="126891004"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="205" mass="23577" checksum="4D959BBA19EFFB50" modified="2025-10-08" version="1">MLLRAYAFEDIVIGTCRCPEVAGNSTPLEKHQQWLKDDAKAASLLAGTLGKTVAELVLTCTHASEIWDKLRARFERSSTQRLNMLIEAFFRVQRDEKEDISTHVAKLQKLFVDLNDELQKHDENVLSERMLNDKAESVNQNQSECFSVNENSEEVKNDVNEIVKSKNMESAESTTENQEVNREDRSDDGVQESKRYNMRIRKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1A5</accession>
    <name>A0ABM5L1A5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050512842.1">
        <property type="nucleotide sequence ID" value="XM_050656885.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516225.1">
        <property type="nucleotide sequence ID" value="XM_050660268.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656885.1">
        <property type="protein sequence ID" value="XP_050512842.1"/>
        <property type="gene ID" value="LOC126888539"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660268.1">
        <property type="protein sequence ID" value="XP_050516225.1"/>
        <property type="gene ID" value="LOC126891090"/>
    </dbReference>
    <dbReference type="GeneID" id="126888539"/>
    <dbReference type="GeneID" id="126891090"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="192" mass="21806" checksum="BBCF87863A557C80" modified="2025-10-08" version="1">MPSCFREVFHDKTTIIIDCFEVFIQKPASYLTQQQTWSNYKHHNTVKFLIGITPQGCISYISKAWGGRTSDKQIVELSGFLDKIEPQDIVIADRGFLIKEFLDVLQAKLVIPAFTKGKKQLLPLELEETRNIAQVRIHVERVIGSIKNKFNIFSEPLPISMLTHVTDGINIVDKIIFIACVLINLCPPIVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1U0</accession>
    <name>A0ABM5L1U0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516407.1">
        <property type="nucleotide sequence ID" value="XM_050660450.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660450.1">
        <property type="protein sequence ID" value="XP_050516407.1"/>
        <property type="gene ID" value="LOC126891271"/>
    </dbReference>
    <dbReference type="GeneID" id="126891271"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="8">
        <location>
            <begin position="71"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="391" mass="45000" checksum="C7A24374112BC072" modified="2025-10-08" version="1">MAATDAFSENDAMRFFQQYGYIDSNSIANFNLTLLHFQQKYNLYVDGTLNDETIALMQKPRCHTGENAYSLKGKWYKHNLRWYFPQAYNVKDLIQLVERAFKIWKDVSNLHFTRVTVPVPKPDITITAVKRKHYFRSNCMGGQKCGFDFDGRGGTLAHSYFPINNDSCVEIHLDLDEKWSYNLNDPDYDSTNLFMVVLHEIGHSLGLLHSNDETAVMYPWYPNKLQNISQDDISGLEALYGRKSTSIPSQYSALTPSSPRKSTYIPTQTSATPQSHISRVHTTRYRPRPTEIIPHQATKTAPHFCAIEYPNSLFLAYDPQFKNHHMYIIHEGFVWKNDINGHMVPNNPEHLSTYLPKQLRNISHVFQNIAGNLIVTSNNTMYSVSFPSITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L281</accession>
    <name>A0ABM5L281_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515019.1">
        <property type="nucleotide sequence ID" value="XM_050659062.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516436.1">
        <property type="nucleotide sequence ID" value="XM_050660479.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516549.1">
        <property type="nucleotide sequence ID" value="XM_050660592.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659062.1">
        <property type="protein sequence ID" value="XP_050515019.1"/>
        <property type="gene ID" value="LOC126890209"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660479.1">
        <property type="protein sequence ID" value="XP_050516436.1"/>
        <property type="gene ID" value="LOC126891301"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660592.1">
        <property type="protein sequence ID" value="XP_050516549.1"/>
        <property type="gene ID" value="LOC126891419"/>
    </dbReference>
    <dbReference type="GeneID" id="126890209"/>
    <dbReference type="GeneID" id="126891301"/>
    <dbReference type="GeneID" id="126891419"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="651"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="738" mass="83659" checksum="AEC1C1E4596B0B85" modified="2025-10-08" version="1">MDNSKPKQKTLTSFFSASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEGKLGCKVCFEVTTMGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKAIFRSAYYIAKNDRPYNDHFGLLELQKLNGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVSGKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2T5</accession>
    <name>A0ABM5L2T5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FP protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516748.1">
        <property type="nucleotide sequence ID" value="XM_050660791.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660791.1">
        <property type="protein sequence ID" value="XP_050516748.1"/>
        <property type="gene ID" value="LOC126891609"/>
    </dbReference>
    <dbReference type="GeneID" id="126891609"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FP protein C-terminal" evidence="2">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30729" checksum="D3D9BC5539671469" modified="2025-10-08" version="1">MCSICKGNYFHESCAEKSGAMKGNTIKCGKCAKSEVKSDEVDFSSNKSKEISEFQKLFQKMEESMEFLSSKFDTLTVENQNALRELRDMKRENIQLKTKVSQLEKRICELEIKEFSCNLEIHGTQIKNEDPKEVLMEIANDLLSCNFNSQDVSDCFKQETKNGAIIVAKMRSRDIKTKFIKARKNRKMESNMLSCNKNKENTSKIYINEQLTFTNRNLFNIAYKLKKERKYKYCWTKNGRVYVKKSDDSEPIYIHNEDIIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4G1</accession>
    <name>A0ABM5L4G1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose dehydrogenase [FAD, quinone]-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517328.1">
        <property type="nucleotide sequence ID" value="XM_050661371.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661371.1">
        <property type="protein sequence ID" value="XP_050517328.1"/>
        <property type="gene ID" value="LOC126891993"/>
    </dbReference>
    <dbReference type="GeneID" id="126891993"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF208">
        <property type="entry name" value="RE36204P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046220218" description="Glucose dehydrogenase [FAD, quinone]-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="451"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68989" checksum="6439C1967CC7C1A2" modified="2025-10-08" version="1">MYYLIITGVLWQICFVSTLIPPSYINVQIDNAFSKSITNQTFDFIVIGSGPTGSVIANRLSEVPEWNVLLIEAGTIPSAISDIPAICGHFQFTGYDWGYRTERQNGFCKGCIRNSLKYGHGKVLGGTSIINFMIHVRGNRRDYDRWAKMGNPGWSYQEVLPYFLKSEDAHIERADAGYHKKGGYLTISDVPFRTKMIDALVQSAQECGHPYVDYNGKEQLGVSYVQTHTRNGRRCSAEKAFLRPVAHRSNLKILTNSKVVKILIDPTTKSAYGVQYARKKKYYNAFASKEVIVSAGGLNSPQLLMLSGIGPKEHLQEFDIPVIANLPVGKKMYDHPSFMGMGFEIDEEIVLRQDEVLTNVTEILTFLKLGNGTMTSIGGVEGLIYMKSKISTDPDPLYPDMELILLGGNLASDNGHLLRRMFNIPRDIYEKVWKIYESKPMYQIMPMLVHPKSVGYVKLASKNPFHFPKFYANFFSDPENKDIKTFIAALREVQRMSQSPTMKKLGTRLIQTPIPGCETMPFDSDEYWECALRSLTSSLWHQVATCKMGPKSDPEAVVDNTGKVHGLKHLRVADTSIIPMPLTAHTAGPSYMVGERISDFIKEEWRTNKYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4J4</accession>
    <name>A0ABM5L4J4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517363.1">
        <property type="nucleotide sequence ID" value="XM_050661406.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661406.1">
        <property type="protein sequence ID" value="XP_050517363.1"/>
        <property type="gene ID" value="LOC126892002"/>
    </dbReference>
    <dbReference type="GeneID" id="126892002"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="276" mass="31861" checksum="2F0B708B72FD0B14" modified="2025-10-08" version="1">MFKADIKDLSSNAYQIYIDASKSTKGTACAVYDPQTNESKMFKLNANSSIYSAELIRILEALKYCHLPNKTIYIFSDSKSALQKIKHLQSAPKINYIILEILQKAEELNKNFKTIHLIWVKSHCGILGNETVVVLAKRAIHEGEGTKYKCTINEIITVIKNVWKTKWEEDNKNNQKGKHYKEIQERIPQKPRFIKGNLSKNAIRKICRLRINHVPVPKFLFKIRLKTDPYCKCGEIGDAEHQILNFSLIQAQVKIFLDKICKLKDVIHPINLKFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4P6</accession>
    <name>A0ABM5L4P6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517411.1">
        <property type="nucleotide sequence ID" value="XM_050661454.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661454.1">
        <property type="protein sequence ID" value="XP_050517411.1"/>
        <property type="gene ID" value="LOC126892033"/>
    </dbReference>
    <dbReference type="GeneID" id="126892033"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF28">
        <property type="entry name" value="NANCHUNG, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="93"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="274" mass="31927" checksum="564FAF13B6F343DB" modified="2025-10-08" version="1">MKKGHWASVCRKNKVRSVKIDLLELENKYNIVEYESDDELETLTEQDRESELKLNDSPKTVSETIGAKSLPVSYESQFVSTPKLPRNIAEIPISAYYIIFLSFDNPLTPEYVDDSATNPISTPMESIMAMFLMSLTNFGDYYDAFARTEHEYEAKILFVIFMAIVAILLINMLIAMMGNTYQKIAETRNEWQRQWARIVLVVERGVSPPERHRQLMVYSQPMSDGKQALVLRLNQSDEDKEEMKEILEIKRRHERYVKKRKEANQIHANNVIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5B8</accession>
    <name>A0ABM5L5B8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517636.1">
        <property type="nucleotide sequence ID" value="XM_050661679.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661679.1">
        <property type="protein sequence ID" value="XP_050517636.1"/>
        <property type="gene ID" value="LOC114330677"/>
    </dbReference>
    <dbReference type="GeneID" id="114330677"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF29">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045902649" description="Saposin B-type domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="13">
        <location>
            <begin position="167"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="691" mass="78998" checksum="D568C37F3F6A1AB2" modified="2025-10-08" version="1">MKWWFVGWLAIAVLVGTTWSQEEKVEAIHKKSPNVRLLSNQTANLIKAIGQAAATGSKNLANLTGTIVKPISLDIGSKIEQSGNKVARVIEAVGNTSALVANKSIGIAEHAAKKLVDFFLSDDEIKKIEGDFAKRMGLHHHKEVDAEKFRSLLGELVDSQTRIFDSDRNYCGLCKLLIKKVQLFGLRISKVAEFICRIYVLFTTLTFNGFCKQIIDLNLPVLEYVVNNSQILDPELACTILLQTKECYYPKPALSWVTVLPETTPKYPNNSRDPTKKPLKILHLTDPHISLDYEYKGVVNCGFPVCCKKGLGNKIKGQNAGYWGEYDCDIPPWLYGNTLQHIKHTHKDLDYIYFTGDIIDHEVWNSSVQSNTVRINLAYKALKDTFTIPVYPIIGNHESTPLNLYAPDKEEIVAKGLSTNWLYDLMAKLWSPWLPESALKTVRRQGYYAYSVNDKLKIIGLNNNVCYNFNWWLLLETEYLNEQLQFLIQELEESEQKGQFVHILGHVSVGNQECIEPWEKSYNEIVRRYAHIIKGQFVGHTHTDELKIFYDKHNKPINMAFNGASLTPYVKYNPNFKVMTVDPVNFDILEIETYYFNLTEANLRPDTSPAWKKLYSMKKAYNLPDLSPTSFDVLADKLFNDTNLAKLYFEYYVRRGDPSLKEGCDKNCLDEIRCKIVTTQSLHPQKEQCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L622</accession>
    <name>A0ABM5L622_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517885.1">
        <property type="nucleotide sequence ID" value="XM_050661928.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517886.1">
        <property type="nucleotide sequence ID" value="XM_050661929.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661928.1">
        <property type="protein sequence ID" value="XP_050517885.1"/>
        <property type="gene ID" value="LOC126892399"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661929.1">
        <property type="protein sequence ID" value="XP_050517886.1"/>
        <property type="gene ID" value="LOC126892400"/>
    </dbReference>
    <dbReference type="GeneID" id="126892399"/>
    <dbReference type="GeneID" id="126892400"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66599" checksum="F81E93C1FE7D2AE8" modified="2025-10-08" version="1">MALKESSYLDQLRISSPEAADRYLDKIKQLNCDPYALSEVDFDYGLTYVPPIASMDILTYIVFTHSFYTHEQMRAYKSLAAYKYFKSGFVEKVGFKVINDLVLLIGKVQHSMRARETKLRVWIIAETGGSICTAHCTCMAGLGEVCSHVTAVLYAAEHAAYLKQQKNEKNVACADVKSTWPVPTQSGTHPIEAASLDWGKVIEEKNYKEIPPMDDSEMLDLLQELQNSNCDAVLMRHVEPFASQLSDENNEKVSIPVLFNVYHKKYEKMPLDDLIQLGMKCKMEVTQNIRREIEDKTQDQRKCAEWYRQRTGRVTASIFKDVCRTNVEKPSLSLIKSICYPRKISTRAIRWGINHEQLAIDAYKKETSRNHRDFIVNTIGLVVCMKWPQLGASPDGFVYCDCCAAGTLEVKCPFSLRENGNLQEYASRKDSCLECDKTGTVKMNKKHKYYYQVQAQIFICKLNYCDFVVWCPNFIFIERVLPDIKFWEEIKDKVLNFHAKVIMPELLGRYYTSRVPGGNITKWCFCNNVDDGQPMVQCSYENCNIFWFHIGCVNLLEKPKTRWTCSICNQKLFHDYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6J3</accession>
    <name>A0ABM5L6J3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050518063.1">
        <property type="nucleotide sequence ID" value="XM_050662106.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662106.1">
        <property type="protein sequence ID" value="XP_050518063.1"/>
        <property type="gene ID" value="LOC126892546"/>
    </dbReference>
    <dbReference type="GeneID" id="126892546"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="280" mass="32404" checksum="D3705594B60269C4" modified="2025-10-08" version="1">MDIKVEIKEELEQYDNGFSSEDVPYNMQSGVSTEDIKDVKKETQQDDSGFPEINNKTEITKTSPKRSYDKQQPISQHAKETIIQQKPYKCEICLKQFTTAGHVKIHLRIHAGEKPYKCEICLGQFSQKSYLKKHKKVHTGEKGYKCNICCKTYTSADNLKKHLRAHTGEKPFECDICSKPFIAACDLKRHLRTHTGEKPYKCDLCPVQFSQQSHLIRHKKGHSGEKNHKCEICCKRFVAADKLKTHLRTHTGEKPYKCEICLRQFSLQGNLITHKKVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7I6</accession>
    <name>A0ABM5L7I6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518403.1">
        <property type="nucleotide sequence ID" value="XM_050662446.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662446.1">
        <property type="protein sequence ID" value="XP_050518403.1"/>
        <property type="gene ID" value="LOC126892765"/>
    </dbReference>
    <dbReference type="GeneID" id="126892765"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="280" mass="31596" checksum="4A3DD8530DE6DC04" modified="2025-10-08" version="1">MTFLKISASMPEYNHILSFRRQIYISPHSLTLPETFTVVFDNTIYRIFISQDSLVCFRCKKPGHIASQCSEPLAQLNTNQNNEASISSATNISSQAPNDTNPSQCEQMSISNVPEIPNKVDALNKDSHIINQPKRNFDEIISPEADPSSKERNIFPPPKVQAKSKKAKISSASTSECSFSLLLDPAKNFIENHPLPFPLNFDQLDMLLTNITGSTDHIATIKEYTTDLEALTEMLIEVYPHLKERSIKRKITSLRKKIHKYLGSEEASDWESDTSQLSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAL6</accession>
    <name>A0ABM5LAL6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H oxidase (H2O2-forming)</fullName>
            <ecNumber evidence="3">1.6.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NADH + O2 + H(+) = H2O2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11264"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050519480.1">
        <property type="nucleotide sequence ID" value="XM_050663523.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663523.1">
        <property type="protein sequence ID" value="XP_050519480.1"/>
        <property type="gene ID" value="LOC114325141"/>
    </dbReference>
    <dbReference type="GeneID" id="114325141"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09820">
        <property type="entry name" value="dual_peroxidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034821">
        <property type="entry name" value="DUOX_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF208">
        <property type="entry name" value="DUAL OXIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046021236" description="NAD(P)H oxidase (H2O2-forming)" evidence="21">
        <location>
            <begin position="21"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1161"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1216"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1271"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1301"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1330"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="926"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="962"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="1351"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1630" mass="188397" checksum="E21E3BD613239A65" modified="2025-10-08" version="1">MYLVFLILGVLHLCHQPVISQQPAIPVNPPANPVPTPAPATTPAPTQTFGGKPPDSVWVGNYTTNKQRRHIFGDWLLNGNWSDNFTPSPTSKTVEYPGYDGWYNNLARPDSGAIDRPLLRRWPAAYEDGTYLPSGSDRPNPLVLSDQLLSGAIGQKSNIGRNALFVFFGQQVVEEILDAQRPACPPEYFNIDIPDNHTYKLEHPKHSKLPLLRTRYDMRTGYSPNNPRQQLNEITPYIDGGLHYGITKQWSDQLRTYANGTVDRRGRLASSHDGLFPEYNTNRLPMANPPPPFHHALYVKQHETAKVARFFKLGNPRGNENAFLLTFGIMWFRWHNYLAERIYHHHPDWSSEKIFNEARKWVVATQQRIYLYEWLPQLLNEDNPFGDYVRYDASIDPQIDQFFQSAAFRFGHTLVLPGVYLRDYAREGCKTTFSNWKQNAIRTCNIFWRPQDPMLTKYDDNQSLINMDRILMGMSSQLSEREDHQIVEDLRGNVFGPLEFPRRDLMAVNIQRGRDHGLPDFNSARRAFGLKPYTDFSNFTQTNDTFRRRLKDLYGDINKIDVWVGGIMETTPQGPGELFRTIIKDQFRRIRDGDRFWFENEENGLFSSDEMERIRRVSVYDIIMAVTHMDAHDIPKNPFKGPIASDDLLIKSCKFTTTTTTSGIVYHHLLPLNVERLNESCTKPDSYDYFSNSEASYIITWAAVGACIPGVITFAYLLILYKEKQVQINNAQEISQKRKTIKRDSNQANWPLFIVTEWVGPKQPPREIILSFKASLKKICVTCFNGTTLRALDFSNVGATHVTLYFITDRCTIVMNTKHNYDLVVTFESEFLRNNFLAEFEKHFVQSQIVKKELVNLNWSSALKVIVTKDNRQARLEMFFRVVFAQAFKISHSKTEILKVDAHVAKEVIDTELTITEFADALSMTPANEFVKRMFTLIDKDRNGFISFREFVDLMIIFADGTEEEKAKLLFDMYDIDGVGHLKQEDFVTMIHSFLETCGGKVDDKDIQKTVSSMLKNAGAEHKQKLTFEDFKKMIGNDIKKLNTARLGFKGIKEADHSYLAKAKDTIENIYESKQEIEARFKGGTSFEEGNSAKMIDDDQEVVIKTQPVQEQKYAMALKFIELKSKEIFWMSLYTLVLFGVFAERAYYYSVEREHSGLRRIAGYGVTVTRGAASAMMFTYSSLLVTMCRNTITFLRDTVANQYFPFDATLEIHKYIAYWAFIFTLMHIIGHAFNFYHISTQTADDLTCLFRNYFHATHELPKFHYWCWQTMTGFTGVILTLIWVVMYSFALPIIRRKIYNWFWYAHSLYPFFFIFLVLHGSGRLIQPPYLYYFFVGPVVLFTIDATISLSRKKVEIPVIKAEILPSSVTMLEFRKPENFQYKAGQWVRIACMALNKNEYHPFTLSSAPDQDNLTVHIRSVGPWTKLIRSTYETAVSASMKLPKLYLDGPYGEGHQDWNTYDVAVLVGGGIGVTPFASILKDIAQKSSKTRTHCQKVYFIWVSRTQKQFEWLVDIIREVENKDTKQLLSIHIFITQFYEKFDLRTILLYICERHYQRVSNKSLFTNLRAVTHFGRPAFAQFFKTVQYIHPTSQRVGVFSCGPPSMTSSVDQACSKINQQSEMKFEHFFKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2S2</accession>
    <name>A0A6P7F2S2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endocuticle structural glycoprotein SgAbd-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325705</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129636.1">
        <property type="nucleotide sequence ID" value="XM_028273835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2S2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273835.2">
        <property type="protein sequence ID" value="XP_028129636.1"/>
        <property type="gene ID" value="LOC114325705"/>
    </dbReference>
    <dbReference type="GeneID" id="114325705"/>
    <dbReference type="KEGG" id="dvv:114325705"/>
    <dbReference type="InParanoid" id="A0A6P7F2S2"/>
    <dbReference type="OrthoDB" id="6372059at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028250355" evidence="2">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129636.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15990" checksum="06920E88FA78A38F" modified="2020-12-02" version="1">MKILVFILLSLALASAQYYRPENYGRNPNARIISQTQQGPNTDGSYKWSYATDNGITAEEEGRLKGRGSQQEAMEARGGFSYTAPDNTVISLTYTADENGFQAYGPHLPTPPPIPVAIQRALDWIRANPDPRYQPDSRYDGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F341</accession>
    <name>A0A6P7F341_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Octopamine receptor beta-2R</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19 20 21 22" type="primary">LOC114326070</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17 18 19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130069.1">
        <property type="nucleotide sequence ID" value="XM_028274268.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130070.1">
        <property type="nucleotide sequence ID" value="XM_028274269.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130072.1">
        <property type="nucleotide sequence ID" value="XM_028274271.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130073.1">
        <property type="nucleotide sequence ID" value="XM_028274272.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130074.1">
        <property type="nucleotide sequence ID" value="XM_028274273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130075.1">
        <property type="nucleotide sequence ID" value="XM_028274274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F341"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274268.2">
        <property type="protein sequence ID" value="XP_028130069.1"/>
        <property type="gene ID" value="LOC114326070"/>
    </dbReference>
    <dbReference type="GeneID" id="114326070"/>
    <dbReference type="KEGG" id="dvv:114326070"/>
    <dbReference type="CTD" id="41549"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15066">
        <property type="entry name" value="7tmA_DmOct-betaAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000271">
        <property type="entry name" value="Octopamine receptor beta-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="46"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028130069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028130070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028130072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028130073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028130074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_028130075.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="48002" checksum="AB5094DFA73E7174" modified="2020-12-02" version="1">MAELEENSTYANITDKVISEGAWTDDLVLVLKATIMGSIIIASILGNLLVIVSVMRHRKLRIITNYYVISLALADMLVAMFAMTFNASVQIYEEWKFGYFMCDVWNSLDVYFSTSSILHLCCISVDRYYAIVKPLKYPLTMTKNVVAFMILNTWISPAIISFLPIFKGWYTTPENQIFRSKHPDICEFVVNKPYAVISSSISFWIPCTIMIFMYLSIFREANRQEREMYNRHGAALLLHQNNTNGDMLSNSGGSSKTLTHHDINQDLHHTPTKERNLSKMKREHKAARTLGIIMGTFILLWLPFFLWYDTVYLCDSCREHCPQEVVSTVFWIGYFNSTLNPIIYAYFNRDFREAFKNTLQCAFCSLCKRPPSELDYIDHRRPSMRHEDRTRSVYSETYLKHVDRRCSEFGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4V1</accession>
    <name>A0A6P7F4V1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pachytene checkpoint protein 2 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326337</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130471.1">
        <property type="nucleotide sequence ID" value="XM_028274670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4V1"/>
    <dbReference type="FunCoup" id="A0A6P7F4V1">
        <property type="interactions" value="1382"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274670.2">
        <property type="protein sequence ID" value="XP_028130471.1"/>
        <property type="gene ID" value="LOC114326337"/>
    </dbReference>
    <dbReference type="GeneID" id="114326337"/>
    <dbReference type="KEGG" id="dvv:114326337"/>
    <dbReference type="CTD" id="41013"/>
    <dbReference type="InParanoid" id="A0A6P7F4V1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130471.1"/>
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    <sequence length="415" mass="47133" checksum="5F6B6D8681237189" modified="2020-12-02" version="1">MDKSVDVEIILTEYNSNTTKKSIVAVVENYLKNKIFRPNSVINFERENTNILHGVVKTVIIGEIAGYDKSFVDFNNLNINWFVYKLDAEGPLLQNEEDGEEEVTISTQLMLPSESLFNLWENLYYDHSIKQNLLKYAQTMMEFSDKGVDQNIISCNRVILLHGPPGTGKTSLCKALAQKLTIRMGKRFGSGVLIEINSHSLFSKWFSESGKLVNKMFSKINDFIENKDILVCVLMDEVESLAHARNQCVSGTEPSDSIRVVNALLTQIDKIKQHSNVLIFATSNMTEAIDLAFIDRADIKQHLGNPSKYAIYKVYYSCINELIKSKIVTGDTLESTDYLISNEDKQYSPELKKLLDLCETSVGLSGRSLRKIPFLAHALFLEGDQIQLGDFLEAMERAVHKEILERKYFEQIKLT</sequence>
</entry>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028129303.1"/>
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    <sequence length="213" mass="24357" checksum="23B12A7E05F70E89" modified="2020-12-02" version="1">MSSSEEQRQDDITTDALPNPRYGQKDKKIIEEEITYKVDLEEDNPEFQEVRKSNLTSFNTRTKRNNGGKKFSPSTASATVINISHSKDIHVGNKNTYNFSGNEKNKKADIPETSAIRSLKASTQSLSRYDLQFAATHMNSEWKDVARACDIEEGQISQFIADHHIYGTKEVIYQVLLDWFQNDPKGATVGTLCTILWNNNQKDVVLKWTHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F760</accession>
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        </submittedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
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        </lineage>
    </organism>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="5">Whole insect</tissue>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="37"/>
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            <begin position="104"/>
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            <begin position="130"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130682.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028130682.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19471" checksum="44CF00D1EB2A94C6" modified="2020-12-02" version="1">MIPMIPFECKYRKYGFITAMVILILIIIISTLAVTPLDQVYTHLYIETAVSLFSCLVMAVVVIYVAHSLFICLNFSNNTGIFLFLILLSELLVIVDVLEEREPIIISVTLINMVLILIFMNFISKFYEAWKDWKNELKKLALEIKELQHEQAHTSQNLRSFRIPLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8E9</accession>
    <name>A0A6P7F8E9_DIAVI</name>
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        <submittedName>
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        <name evidence="6" type="primary">LOC114326004</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="6">Whole insect</tissue>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_028274167.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="823"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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        <source>
            <dbReference type="PROSITE" id="PS51286"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129968.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028129968.1"/>
        </source>
    </evidence>
    <sequence length="897" mass="106688" checksum="B880ADAE6C4125C8" modified="2020-12-02" version="1">MKIFRIFRSFQNKSNFKRYLSTFTHAKINRAFNNRLSNVKQYTFRQYSTEDDESEDYPFLETETFDQIDCTKYVLFKDSEDVIIRDLNECRSLKDVWKVFNSYKTDFKEKHVAQTIFVLKDLQSLYCRVNCSVDSAFLNYLKEMKQSEDFSNLMNMITEKLSDFNAEVLSYVFLYLHKLGFHTEDFPMVQIAEKIRRDLIEEFNLSNCSKWIKVIFLESGSRPYYMSLELMPKIFNAIDECDSVEQLADISTCLTKLQNMVTPQIVSKYVDKVQNFIEHKKLTSTDHNAILKVITFLSCPGWRNENTILLCKCMLLLKNQINRLDAARLLVLYEVFFKTQEPGDLLNEIQRCAAKYWQQHEESNNLDNNTALKLFSSLIYFNSPLHRIHVRKDIQKLLKDKMSPSNLSLLRKIFSYVKISDNVLCHNYWRVWSNILNEDSSMYLLVMACQNYMQFNTDIDNYRNNDFEKKVLGLIRDLVRNEELLFPQDLIVLLTFVILYGRDKMLLEVLLGKLRDNPTQLKGKDLFVLSKFFKRNHLSLSERQYNDIKRIFRETSDHLLNENNFETNALLVKSAILRNEYDSYQIDTLITEFKAMEYMSSKFLEHINFIFMTTNTLVPEVFNKMTEYIINNKNNIVGFNAEKLLFLCFHLAYLPINADKFFQTVTDIIIRDQERLSGLAFLQSALSLSFFNKLPSFLVKQIFNVEFMDRLDNELANCYSKEKYPQRVRQTLMYLNRSVCLEYPEFNVPWFHEKYLKDVRKTYNTEMEYTYSKSIKEYLVEIAESHIMESITTPYGYYIDFVINLNKEECVVSPSSKSISRRVALLLVHQYAFTRFYSHLRGTYQMKIRHLEIMGYSVSIMKIDEWTNLLYASERIEYLKKLIWPDNWNTIQCLPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB49</accession>
    <name>A0A6P7FB49_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-terminal methionine N(alpha)-acetyltransferase NatE</fullName>
            <ecNumber evidence="5">2.3.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114326573</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50564"/>
            <dbReference type="Rhea" id="RHEA-COMP:12726"/>
            <dbReference type="Rhea" id="RHEA-COMP:12727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133398"/>
            <dbReference type="ChEBI" id="CHEBI:133399"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50580"/>
            <dbReference type="Rhea" id="RHEA-COMP:12734"/>
            <dbReference type="Rhea" id="RHEA-COMP:12735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133406"/>
            <dbReference type="ChEBI" id="CHEBI:133407"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50568"/>
            <dbReference type="Rhea" id="RHEA-COMP:12728"/>
            <dbReference type="Rhea" id="RHEA-COMP:12729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133400"/>
            <dbReference type="ChEBI" id="CHEBI:133401"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50576"/>
            <dbReference type="Rhea" id="RHEA-COMP:12732"/>
            <dbReference type="Rhea" id="RHEA-COMP:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133404"/>
            <dbReference type="ChEBI" id="CHEBI:133405"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50572"/>
            <dbReference type="Rhea" id="RHEA-COMP:12730"/>
            <dbReference type="Rhea" id="RHEA-COMP:12731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133402"/>
            <dbReference type="ChEBI" id="CHEBI:133403"/>
            <dbReference type="EC" id="2.3.1.258"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.258" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028130773.1">
        <property type="nucleotide sequence ID" value="XM_028274972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB49"/>
    <dbReference type="FunCoup" id="A0A6P7FB49">
        <property type="interactions" value="1765"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274972.2">
        <property type="protein sequence ID" value="XP_028130773.1"/>
        <property type="gene ID" value="LOC114326573"/>
    </dbReference>
    <dbReference type="GeneID" id="114326573"/>
    <dbReference type="KEGG" id="dvv:114326573"/>
    <dbReference type="CTD" id="44724"/>
    <dbReference type="InParanoid" id="A0A6P7FB49"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000078">
        <property type="entry name" value="N-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028130773.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="19087" checksum="C0861748D392DA71" modified="2020-12-02" version="1">MTRESIELGNVTPHNIKQLKRLNSVVFPVSYNDKFYKDVLEAGELAKLAYYNDIVVGAVCCRIDTSEKSRRLYIMTLGCLYPYRRLGIGTLMVQHVLNYVEQDGNFDSIFLHVQVNNEGAIDFYKKFGFEIVETKEHYYKRIEPADAHVLQKTLRNKGQMNGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCB6</accession>
    <name>A0A6P7FCB6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC114327943</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114327943</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132467.1">
        <property type="nucleotide sequence ID" value="XM_028276666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276666.2">
        <property type="protein sequence ID" value="XP_028132467.1"/>
        <property type="gene ID" value="LOC114327943"/>
    </dbReference>
    <dbReference type="GeneID" id="114327943"/>
    <dbReference type="KEGG" id="dvv:114327943"/>
    <dbReference type="InParanoid" id="A0A6P7FCB6"/>
    <dbReference type="OrthoDB" id="6715219at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028132467.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46385" checksum="8612102063FB2D58" modified="2020-12-02" version="1">MSTFTVVFLLLFVSFYVISLSTYTYITSLPHLSNNTISRENKIRVKRIASNDYQLKDEVLMTNLNTINNIDYSNGTTKPNIPNTIPTEKMVTLNKCCADNQYLNPNYECQDGDEDISSEELLNKISDYFENASTERNYINQNTVNLKYNYILRLRNEHAFALIWPSSNTSQRYTFNRKELFLNEFIHINKTRLVTSFSPQSFCVDILSSGGYLVTFVNPCIEKICIQKCCPKGFYYNIRDKLCVVDPAFTNNFEPTFHVENHKIQKQPQYYVLDKNFKCSDNAFMQKLQMERLDGSLYLQEDGSLMTFQGAIQGDSYNMTDYCIDQVYDGNSENAVIGGFICQLIKENPERLKLNQTLSLEPRLRKQQKLDDLKILSSCCNIPTVIVIELIGCLLAAIFFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDC7</accession>
    <name>A0A6P7FDC7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114327092</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131393.1">
        <property type="nucleotide sequence ID" value="XM_028275592.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FDC7">
        <property type="interactions" value="1549"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275592.1">
        <property type="protein sequence ID" value="XP_028131393.1"/>
        <property type="gene ID" value="LOC114327092"/>
    </dbReference>
    <dbReference type="GeneID" id="114327092"/>
    <dbReference type="KEGG" id="dvv:114327092"/>
    <dbReference type="InParanoid" id="A0A6P7FDC7"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028432123" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="40"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="295"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="16">
        <location>
            <begin position="436"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="17">
        <location>
            <begin position="711"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="18">
        <location>
            <begin position="1216"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1502"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028131393.1"/>
        </source>
    </evidence>
    <sequence length="1514" mass="172054" checksum="548A9BC0A53F7EFD" modified="2020-12-02" version="1">MKFLTLSTVFIIFLSISENVNGKAKKSKSVTTLLEAKWQATPLVLETAEYLADENIDFFWGFVDSISSLETPLSSIGSEHEQYKTVIKHASKFLTPSQIAVLKLGLSLHVYSPKVQMFAQIAQELRLPDCPSVADIGGTVVCNVEDINSLINEPSENHKRIELHRIDNHFPGSANRSLAVVLYGQIGTKSFGKFHRVLKQAAVDGKIDYVIRHYVKGNDSKNLRLSGYGVELQMKSTEYKSQDDTELHEDQNSAEASQEDEDTELEGFDFAKLKQIFPNLKNQLDKFKTHLEDTSSELAPLKVWQFQELSLQAAERIMNAPREEALKILTNTAQNFPMQAKGLAKTTVNADLKAEMKKNSNMFAAHLNLQPSDTALFINGMFYDIDLVDVYGILEILRQELKTMEGLHGLGIGNKRMSSLLELDFGDDQNGQDFAIDIRDSAINWINDIEQDPKYARWSSSLMELLRPTFPGMLRQVRRNLYNLVLIIDPTDKSSAELLKLVESFVVHTAPIRVGLVFNVTAKSDVTGLEDVGVAMQCALNYITQSKDAATALTFVRTLLKSVEEKLTVEDIKKQLRKDYDDDPVDILGEDSVYDFGRQLSADFIERVGLKVFPQALLNGVPFPQEQVNVDDFEETILQEVMTQTHSFQKSVYRGKLSDSDDVFDYIMNQPKVMPRLNDRILNKDRSIHLDMTGTASSINNLESLLKLNTRDMTATAIENVRYFSAPKKSGQYHSMTYWIIGDLNCKKSRTLLLDALNHLKAETHVRVSFLPNVNGGKDNTLNKIVLAALQELPSEKALPLVISLLKDDAAARKLENGEKLDLPVEVSSKINAQELNLKMLRIYCQRVLQLKESQRSVIANGRVLGPLEENEVFTSEDFSLLDRFSSSTYWEKIKAALDKNSDDEDDISSNSLMKLISLLIARPQSKSRFEINFSGDEHSVIKIPPAHPDRVAFDIAAIVDPVSRGAQKLGPILQVLQEVLNCRIRVFLNSVEKNSDMPVKSFYRFVLEPEIQFGEDGKQLPGPIARFNNMPTSPLLTQNYHVPENWLVEVVRSVYDLDNIRLENVESNVHSEYELEYLLLEGHCFEQSSGSPPRGLQITLGTESQPVIVDTIVMANLGYFQLKANPGAWLLRLRQGRSADIYDIVSHEGSDTPENSTDIKVLISSLRSHIVKLRVQKKPDKANVDLLSDDDNNNGIWSSITSSFKGSEDESDEKLNIFSLASGHLYERFLRIMMLSVLKHTKRPVKFWFLKNYLSPQVKDFLPYMAKEYGFEYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLDVKKIIFVDADQVVRADLKELQELDLGGAPYGYTPFCESRKEMDGFRFWKHGYWRNHLQGRRYHISALYVVDLKRFRRIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPQEWLWCETWCDDASKDKAKTIDLCNNPMTKEAKLTAAVRILPEWKGYDDEIRNLQKKIDSGLLDADPAENSDVSEKERTDTHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDH5</accession>
    <name>A0A6P7FDH5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC114327132</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="18"/>
    <dbReference type="RefSeq" id="XP_028131443.1">
        <property type="nucleotide sequence ID" value="XM_028275642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDH5"/>
    <dbReference type="FunCoup" id="A0A6P7FDH5">
        <property type="interactions" value="1024"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275642.2">
        <property type="protein sequence ID" value="XP_028131443.1"/>
        <property type="gene ID" value="LOC114327132"/>
    </dbReference>
    <dbReference type="GeneID" id="114327132"/>
    <dbReference type="KEGG" id="dvv:114327132"/>
    <dbReference type="CTD" id="6389"/>
    <dbReference type="InParanoid" id="A0A6P7FDH5"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
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    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
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        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Succ_DH_flav_C"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="19">
        <location>
            <begin position="62"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="20">
        <location>
            <begin position="511"/>
            <end position="663"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="339"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="72"/>
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        <ligand>
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        </ligand>
    </feature>
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        <location>
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            <end position="105"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="274"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        </location>
        <ligand>
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        <location>
            <position position="406"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="439"/>
        </location>
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        </ligand>
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        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <begin position="455"/>
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        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="98"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        </source>
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            <dbReference type="Pfam" id="PF02910"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
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    </evidence>
    <sequence length="663" mass="72682" checksum="7A3170393B7D4B8F" modified="2020-12-02" version="1">MSSILKLQAACLKNVIGNSIKLNSLVKPIAATRNLHIQVDRKNASSSDSVSKVYPIVDHTYDAVVVGAGGAGLRAAYGLVQEGFKTAVITKLFPTRSHTVAAQGGINAALGNMEEDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENAGMPFSRTQEGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGQSLRYDCNYFVEYFALDLIMEGGECRGVIALCLEDGTLHRFRAKNTILATGGYGRAYFSCTSAHTCTGDGTAMVARAGLPSQDLEFVQFHPTGIYGAGCLMTEGCRGEGGYLINSQGERFMERYAPVAKDLASRDVVSRSMTIEIREGRGCGPDKDHVYLQLHHLPAEQLHQRLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYKGQVLTTVNGEDKRVHGLYACGEAASSSVHGANRLGANSLLDLVVFGRACALTIAEEHKPGESIGSIKDNAGEESVANLDWARFANGAIPTADLRLQMQKTMQVHAAVFRTEDSLKEGVTKMENLYGKMKDLKVSDSSLIWNTDLVETFELQNLMLNAVQTIVGAENRKESRGAHAREDYKLRVDEYDYSKPLEGQQKKPSTEHWRKHTLTTIDDKTGKVNITYREVIDDTLDKSECATVPPAIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFM3</accession>
    <name>A0A6P7FFM3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome b561 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114329807</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028134839.1">
        <property type="nucleotide sequence ID" value="XM_028279038.1"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="XM_028279038.2">
        <property type="protein sequence ID" value="XP_028134839.1"/>
        <property type="gene ID" value="LOC114329807"/>
    </dbReference>
    <dbReference type="GeneID" id="114329807"/>
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    <dbReference type="OrthoDB" id="907479at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF24">
        <property type="entry name" value="NO EXTENDED MEMORY, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="85"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028134839.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34780" checksum="532B9995BB94373D" modified="2020-12-02" version="1">MVMESNSVSPMPELAPIAEFDKTPPTPPEDTLPMDDLPPPPNTVVNVQEEKEKEAEAEAKAHRHYEDENEWGCGSWLEYTVVVVCASILLLGSLALTLFWVIQYRGGFAWREDPEREFNLHPVLMVAGFITFSGFSILLYRICRCCRRIYVKLLHTIFHALAIPCVAVGFLAVLDSHNLSSPPKPNFYSLHSWIGLVTMGLFALQFVVGFFSFLVLLCCEGATAGFRAALVPIHASFGLTTFMLAIAASLTGLTQKVWLVLKNRYSLHEEEAIIANTIGMSLIALSIIMSYILQRDEFRFRAHILIRSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGX1</accession>
    <name>A0A6P7FGX1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin L-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114327958</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132475.1">
        <property type="nucleotide sequence ID" value="XM_028276674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050643627.1">
        <property type="protein sequence ID" value="XP_050499584.1"/>
        <property type="gene ID" value="LOC114327982"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FGX1"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027611755" evidence="7">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028132475.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36057" checksum="8BA404FDDFBCD447" modified="2020-12-02" version="1">MKLFVAFAVIILSASALSLNDHWENFKVKHGKAYKNPIEERVRFSVFQSNLKLINEHNAKYEQGLVGYTMAINQFADITPEEFKAKLGMQAKNIPNIKKTPHVQDVNAEVPDSIDWRQKGAVLGVKDQGDCGSCWAFSTTGSLEGQNYIINGKSVGLSEQELLDCSSDYGNGDCDYGGLMTSAFEYIEDHGIESESSYPYEGEQGSCRRSSGKAEVNIKSYKEPAANEEALRQAVGTVGPISAAIYADPIQFYSRGIFDSRECVNDRDYLDHGILVVGYGEENNEPYWIIKNSWGADWGEQGYFRLKRNAKLCGLSLMTSYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKT7</accession>
    <name>A0A6P7FKT7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114328790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114328790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133548.1">
        <property type="nucleotide sequence ID" value="XM_028277747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKT7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277747.2">
        <property type="protein sequence ID" value="XP_028133548.1"/>
        <property type="gene ID" value="LOC114328787"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FKT7"/>
    <dbReference type="OrthoDB" id="6736457at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028170544" evidence="1">
        <location>
            <begin position="16"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133548.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="68884" checksum="2B92ECEC4999D377" modified="2020-12-02" version="1">MKVLVLFSLVVLSVALPTLLGRTVRVKEDGTVSLFDSRGYQLVILKSVADPSQVEVVLRSPNTRTQMFQVGEPLRTGEAIDRRTLAGVSVYQNYNQADILTDIFRQYEGILDDTKYYNLLNRIQMLVEAGLINETIYDVIRNWDREYRMQGISDIVPVQGVRTLRQYAEQVGDVMPLGQNLQYGNQRNWALDQGLLQTYSPLRHFQTLLGQIQQQRVLQQGLLTQQQYLPQQYLSGEYLLEDQMNTNQILNQIYRQQLGQSPLNRYLVNMRLVNGEQVYEVPEEFVNVQLLEQLFAKQELINQELTEITERRQPITEDVHYQQQLINQQIQKLIEQLAYHQNLITREVEQYIVKGQVVPQELVSQQRLVYQQVHEVIERLTSQQIFLNHLAESTEATEVDTISIQRWVVQQNIINEQIQQLIQQVLYQQTHVRQQIQVLIQQGHVIPQELVLYQKITYQYVERFLQVLIKQFVNQQTNYKQLIQILGQQRHTIPQELVSQYFAMYTQLLQLIQHGDIVPQELIYQQRQIHQQIVLMLQQLKVVPQQLVNQLVFNTQDRMWQTQGTYQRVPLMMQRTYQRVPLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMS4</accession>
    <name>A0A6P7FMS4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114331923</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137416.1">
        <property type="nucleotide sequence ID" value="XM_028281615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMS4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281615.2">
        <property type="protein sequence ID" value="XP_028137416.1"/>
        <property type="gene ID" value="LOC114331923"/>
    </dbReference>
    <dbReference type="GeneID" id="114331923"/>
    <dbReference type="KEGG" id="dvv:114331923"/>
    <dbReference type="InParanoid" id="A0A6P7FMS4"/>
    <dbReference type="OrthoDB" id="10061449at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000004">
        <property type="entry name" value="Tryptase gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027550402" evidence="3">
        <location>
            <begin position="19"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="33"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028137416.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="28620" checksum="FE35B9D1907CAC23" modified="2020-12-02" version="1">MVGLKVFVLFGLLATTYGFNQIKSRNTRNGLDLDGGTEATDGQFPWVVSLQSNFLFVNTHVCGGVILNENWVLTSAECEGAANKVVAGAVKLQGADPNKQTVDIERWVVHPDYNSQVVGPNDIALVKLKQPLKFNDAIKAANLPEQGAAVTGLADVVGYGNSFLPDFNTLSYISDLPLISYDDCNQALEDLIQEKSPLDEKSNICAGVLANGANNCNGDTGSPLTQDNFVIGITTWIITPCHSRGAPDVFTNVANFVDWINENISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNS5</accession>
    <name>A0A6P7FNS5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114332402</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138004.1">
        <property type="nucleotide sequence ID" value="XM_028282203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNS5"/>
    <dbReference type="FunCoup" id="A0A6P7FNS5">
        <property type="interactions" value="1561"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282203.2">
        <property type="protein sequence ID" value="XP_028138004.1"/>
        <property type="gene ID" value="LOC114332402"/>
    </dbReference>
    <dbReference type="GeneID" id="114332402"/>
    <dbReference type="KEGG" id="dvv:114332402"/>
    <dbReference type="CTD" id="41968"/>
    <dbReference type="InParanoid" id="A0A6P7FNS5"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000269">
        <property type="entry name" value="Single-stranded DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028138004.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16709" checksum="38CB4A5B2E1511C8" modified="2020-12-02" version="1">MISSKVVKCLPSLLKQRAPSCISAVRNNATVQQEPPRIEKTINAVQLLGRVGADPQKKGTEQHPIAVFSLATHTNYRYESGEFMQRTEWHRIVCFKPGLRETILNYLKKGQRVHVSGRITYGEVRGEDGKPKTTTAIAADDVIFFNSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQZ0</accession>
    <name>A0A6P7FQZ0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC114330188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114330188</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135315.1">
        <property type="nucleotide sequence ID" value="XM_028279514.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502827.1">
        <property type="nucleotide sequence ID" value="XM_050646870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQZ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279514.2">
        <property type="protein sequence ID" value="XP_028135315.1"/>
        <property type="gene ID" value="LOC114330188"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646870.1">
        <property type="protein sequence ID" value="XP_050502827.1"/>
        <property type="gene ID" value="LOC114330188"/>
    </dbReference>
    <dbReference type="GeneID" id="114330188"/>
    <dbReference type="KEGG" id="dvv:114330188"/>
    <dbReference type="InParanoid" id="A0A6P7FQZ0"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647:SF4">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027799029" evidence="6">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="7">
        <location>
            <begin position="37"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028135315.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17267" checksum="44F822627FD4830E" modified="2020-12-02" version="1">MHMWSILVPLILIFYYCDSYTETEEYRKQCAEAAPKKILCGNRLSGTMNLVCAGRYYDKNYPHEQRTDKSILYGDYDPNAGPVSSTFSSRSSLRSLLVGRIRSHGAVNECCYRPCGPATIIEYCQDEMGPNDSYCRWIEHASQWFQPDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FT31</accession>
    <name>A0A6P7FT31_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114330888 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114330888</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136113.1">
        <property type="nucleotide sequence ID" value="XM_028280312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FT31"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280312.2">
        <property type="protein sequence ID" value="XP_028136113.1"/>
        <property type="gene ID" value="LOC114330888"/>
    </dbReference>
    <dbReference type="GeneID" id="114330888"/>
    <dbReference type="KEGG" id="dvv:114330888"/>
    <dbReference type="OrthoDB" id="6780401at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028136113.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="56270" checksum="A7CF1294A7D73D6D" modified="2020-12-02" version="1">MAFILPDNILETLLCNFCHKYLSVKPVKVYPNRLMQCGRCNENEEHSNHIMLQAVESQYGKIAENILFKCINRFDGCRELLRYSEVQDHEQVCLNKIRKCPICYEEIVSFRMLRHFRSNHKDAILDCPVFVFHMNDHLEMPSVYIYQEEDNLFFIYIVRSKSENTIRLDLIYMGNFQRAKNIYHQFTVSSENKEFDIVLGPKPCTNDFVVVDISKMSNFVQIKFKLIDRNLKVLTTEISNAGGVRKPVLKNAPDGHQIGKKQSEVNLRCIECQEYCIFSLSTCPILFYFIDKRKDYLCYYCHQWFKYCEFNKRVIPKEIITDIMQFFKWICSDCCSYIEFLDMKSHELNCKQGRQFSCPIENCCEKGTANEMIEHLKVHNCLAFSSHFKLTSDILRCYAFVKKYIVYLHLTRYSWNTVKLVTETDNDGHSTTLKPHVMFFDNNNKLLNGYNRDTSIPDISTDEIFVKVIVKKCYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTN6</accession>
    <name>A0A6P7FTN6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114331048</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136323.1">
        <property type="nucleotide sequence ID" value="XM_028280522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280522.2">
        <property type="protein sequence ID" value="XP_028136323.1"/>
        <property type="gene ID" value="LOC114331048"/>
    </dbReference>
    <dbReference type="GeneID" id="114331048"/>
    <dbReference type="KEGG" id="dvv:114331048"/>
    <dbReference type="InParanoid" id="A0A6P7FTN6"/>
    <dbReference type="OrthoDB" id="6625921at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028136323.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40301" checksum="1E8B863F49421D96" modified="2020-12-02" version="1">MPIQRGKIGTITFGWLSGPMIYAYVFYVITTVIVLLVGYERVDILLNKSKKFDEYIYSIIFIIFLVPHFWIPFVGWGVAKEVCDYKNGWGFYQLHYYKIVGRDMKFPHLSTLIVIISLGCLIVAVMLLLTLSALLDGFTLYHTSAYYHIITMINMNCALWYINCRAIGNASHALADSFQEDIKQNCSAYMIANYRILWLELSELLQAIGNAYARTYATYSLFMITNITVAIYGFTSEVVDHGITFSFKEMGLLVAGLYCLTLLMIFCNCSHQASENIAGRIQTSLFDIRIFNVEQDTTNEIELFLTAIRLNPPTVSLRGFSDVNRRLVTSSIATIAIYLVILLQFKISLVNLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYX8</accession>
    <name>A0A6P7FYX8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC114334181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114334181</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140016.1">
        <property type="nucleotide sequence ID" value="XM_028284215.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140017.1">
        <property type="nucleotide sequence ID" value="XM_028284216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYX8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284215.2">
        <property type="protein sequence ID" value="XP_028140016.1"/>
        <property type="gene ID" value="LOC114334181"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284216.2">
        <property type="protein sequence ID" value="XP_028140017.1"/>
        <property type="gene ID" value="LOC114334181"/>
    </dbReference>
    <dbReference type="GeneID" id="114334181"/>
    <dbReference type="KEGG" id="dvv:114334181"/>
    <dbReference type="OrthoDB" id="7375975at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028140017.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34099" checksum="8DE4AA0255DE386F" modified="2020-12-02" version="1">MNAGLDLPIRSAFIGASAILGKVFFFLMLHLVTGSGGLRLTHMDAPDVVDPRDGLQLDCHFDMGSEELYAVKWYKDDQEFFRYMPRQNPHTLMFPVSGVSVVPHESDCDITRCKVRLHKLSSRYSSGAYRCEISSEAPAFRLAAETHNITVAALPREKPKIDGLASVYAEGDILTAECTSDFAYPIPVLRWYVNGEPAIPVARPTIIEKEVDVLVAQTILLRLVVGGNLIKGTSIQIGCEATVPNVSFGPQLTTVNVPLKTTNADGMASNEKLQLWYSAFNASSSLLISSYHVALSILLYIFVRWIFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0C5</accession>
    <name>A0A6P7G0C5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114336133</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028142261.1">
        <property type="nucleotide sequence ID" value="XM_028286460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0C5"/>
    <dbReference type="FunCoup" id="A0A6P7G0C5">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286460.2">
        <property type="protein sequence ID" value="XP_028142261.1"/>
        <property type="gene ID" value="LOC114336133"/>
    </dbReference>
    <dbReference type="GeneID" id="114336133"/>
    <dbReference type="KEGG" id="dvv:114336133"/>
    <dbReference type="InParanoid" id="A0A6P7G0C5"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="11">
        <location>
            <begin position="42"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028142261.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42997" checksum="C0F5B724E9348B61" modified="2020-12-02" version="1">MLNLLYKSSYVFVLFYYAVIPLGYLTKWWVTVEKMKGNSTILVTGGAGYVGSHTVVELLKNNYTVIALDNLVNCYAIGSEKPEALKRVEKITGETVTFYNVDIKDREALDKIFKAHRIDAVIHFAALKAVGESVSIPLKYYHNNVGGSATLFEVMAANGVKKVVFSSSATVYGDPQFLPITESHPTGQGCTNPYGKSKYFVEEVLKDVCTSDPEWKVILLRYFNPVGAHESGLIGEDPSGIPNNLMPYIAQVAVGRREKLQVFGNDYQTPDGTGVRDYIHITDLAIGHLKALNHIYSSSFKSWKAYNLGTGRGYSVLEMIKAFAEASGKQIKYDIVERRGGDIAECYADATLAKIELGWQATRDVMAMCRDTWNWQKKNPKGFQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0D1</accession>
    <name>A0A6P7G0D1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114336212</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028142344.1">
        <property type="nucleotide sequence ID" value="XM_028286543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0D1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647024.1">
        <property type="protein sequence ID" value="XP_050502981.1"/>
        <property type="gene ID" value="LOC126882219"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G0D1"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027634440" description="acid phosphatase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142344.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44654" checksum="A7EE5E0CD7DAE35F" modified="2020-12-02" version="1">MVNILFSKINLLVLLMLHWETGYGVPVENSDDELVAVVAVSRHGDRAPFTSFPTDKYYNLTYWPMGFGQITKKGIDRQYKLGQWLRHRYSSFLSEFYHTKEIYAWSTDIDRTLMSAYASLAGMYPPKGYQLWNEHISWQPIPVHIAPFLSLIENLGCPKFFSMLQKVKESVFPIYEEKHSETLQYIANKTGWPKVSIEMVDELMDLLFTYEEHDLTFVPDWSKTMDHNITRYLSAVVYEIQTHTVPLARLKIGTFYDYLFNFFNKFVDPISLNGRIGITDPTAKNQKSKFVLVMAHESTLSAILNTMRAYNMKHIEYADTLLWELKKRKDGVHYLNVLYKTKSELSPVKILKCDYNCNLEQAKNNLADVTITKKRWHKECLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3K3</accession>
    <name>A0A6P7G3K3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine and glycine-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114337293</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143506.1">
        <property type="nucleotide sequence ID" value="XM_028287705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3K3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287705.2">
        <property type="protein sequence ID" value="XP_028143506.1"/>
        <property type="gene ID" value="LOC114337293"/>
    </dbReference>
    <dbReference type="GeneID" id="114337293"/>
    <dbReference type="KEGG" id="dvv:114337293"/>
    <dbReference type="InParanoid" id="A0A6P7G3K3"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027849898" evidence="2">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028143506.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="6234" checksum="C9E10FA612929612" modified="2020-12-02" version="1">MKKFAVLIAVLLVAMQVASGVAQLGSSQGGQGGMGQGPPSGGPPSGGNGGGSSSSMNGGGGMGGSGGNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G492</accession>
    <name>A0A6P7G492_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gastrula zinc finger protein XlCGF57.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114335743</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028141837.1">
        <property type="nucleotide sequence ID" value="XM_028286036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G492"/>
    <dbReference type="FunCoup" id="A0A6P7G492">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286036.2">
        <property type="protein sequence ID" value="XP_028141837.1"/>
        <property type="gene ID" value="LOC114335743"/>
    </dbReference>
    <dbReference type="GeneID" id="114335743"/>
    <dbReference type="KEGG" id="dvv:114335743"/>
    <dbReference type="InParanoid" id="A0A6P7G492"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000180">
        <property type="entry name" value="Zinc finger protein 689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028141837.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="54695" checksum="072D57B6850A4858" modified="2020-12-02" version="1">MEENKEDTILDISHTELMEIISVNEICRLCANQQEKLIGIYTPDGENNDLASKMNSYLPIKVDKTDDLPLQCCWQCASTVLAWHELFLTSIEADRRLRSYQFVTEKQISETIGTNTDISLEEVTKPIEEVKLPILNKYEENDPVFINKSEMSDYSDNIGEYIGLQQEYLPLDEICESTDKELNEDEKIIDVSDEEDDPLTTKEAGDICYGCQTCQMIFLSEPEMQKHIAQTHPIEEKCDNNDKVELKKSRKKNAKLDQEMVNAAKIVVDGKVYYNCKECGRCLYSPYTYIWHVRIHTGERPHSCHLCGKCFRVSQGLVRHLKETHEGIKNFPCDICGRMFATRRNADEHRRIHTNERPYVCDLCGKSFKQKASLFVHNRSHNDVFPFKCTYCNQTFRTRPPMLVHITKHTGEKPYPCEICGRRFRIKYELKRHRLIHSDEKPFSCELCGLKFKQKRYLKNHIKLNHANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5U3</accession>
    <name>A0A6P7G5U3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein OZF-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114334088</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139905.1">
        <property type="nucleotide sequence ID" value="XM_028284104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5U3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284104.2">
        <property type="protein sequence ID" value="XP_028139905.1"/>
        <property type="gene ID" value="LOC114334088"/>
    </dbReference>
    <dbReference type="GeneID" id="114334088"/>
    <dbReference type="KEGG" id="dvv:114334088"/>
    <dbReference type="InParanoid" id="A0A6P7G5U3"/>
    <dbReference type="OrthoDB" id="10538383at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028139905.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52229" checksum="33024037B660388E" modified="2020-12-02" version="1">MEIKEETVYLSNINKMEIKQENAMSNIKCKIEPDWENYEDTPDLIKCELKGENPDEDYSTTNVDDSGDSKIFLSQIKSEISLDDLKPEPTLKDEMLDYTEETQKSEHGFLNADIQNDSCGLLNNEDIQHSNQNLSVGTSYGCDICCKQFSDPRLLRNHMKYHNGENDFQCKLCFKRFVSNSHLQVHTRSHTGERPYRCEICTKGFHHKSALKIHMRLHTGERPFQCKLCSKKFLQACHLKNHIRMHTGEKPYSCHICSKQFSQATNNSHMLFHSGEKSLSCKFCSKQFSLASHLDTHMRSHTGEKPYQCRVCDKRFINISSLKTHSQIHSGKIPHQCEICYKGFSSKNCLRTHVRLHTREKLFTCDYCPKQYTQRGNLRKHTLIHVKELKCKICSETVSGKDNLLIHMESHEEEKPLKCGLCSKRFQRGSNLKVHQRSHCGKKPAPTLIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5U8</accession>
    <name>A0A6P7G5U8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-pass membrane and coiled-coil domain-containing protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114338019</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMCO4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144396.1">
        <property type="nucleotide sequence ID" value="XM_028288595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5U8"/>
    <dbReference type="FunCoup" id="A0A6P7G5U8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288595.2">
        <property type="protein sequence ID" value="XP_028144396.1"/>
        <property type="gene ID" value="LOC114338019"/>
    </dbReference>
    <dbReference type="GeneID" id="114338019"/>
    <dbReference type="KEGG" id="dvv:114338019"/>
    <dbReference type="InParanoid" id="A0A6P7G5U8"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027960">
        <property type="entry name" value="DUF4519"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644:SF2">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15012">
        <property type="entry name" value="DUF4519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028144396.1"/>
        </source>
    </evidence>
    <sequence length="60" mass="7055" checksum="A3EBE381E780F737" modified="2020-12-02" version="1">MRNKAGKVKETSKEKKQRKKDFQETQKQVKTIVLPGLIVIAIFIIIYVYMKTRPKNGYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7Y1</accession>
    <name>A0A6P7G7Y1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114338828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114338828</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145241.1">
        <property type="nucleotide sequence ID" value="XM_028289440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7Y1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650965.1">
        <property type="protein sequence ID" value="XP_050506922.1"/>
        <property type="gene ID" value="LOC126884750"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G7Y1"/>
    <dbReference type="OrthoDB" id="6775254at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028145241.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19713" checksum="7FB68C45F44323A5" modified="2020-12-02" version="1">MESSSVTPPTDEEDPTIKHAKEALYEIKADIIVKFDDIKLETKENLENINEILKETIEKTVDKTKKELDPETLKLVEEAKQKVQHIHEQTTATLDKLWKGSACAIQTLGATANAALNSESLEAYITEIINSIEAVVKELLEYFETLVTYILQEQQIFIEKIKIKLTSDNYILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEJ1</accession>
    <name>A0A6P7GEJ1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4E-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114336364</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142520.1">
        <property type="nucleotide sequence ID" value="XM_028286719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEJ1"/>
    <dbReference type="FunCoup" id="A0A6P7GEJ1">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286719.2">
        <property type="protein sequence ID" value="XP_028142520.1"/>
        <property type="gene ID" value="LOC114336364"/>
    </dbReference>
    <dbReference type="GeneID" id="114336364"/>
    <dbReference type="KEGG" id="dvv:114336364"/>
    <dbReference type="CTD" id="33569"/>
    <dbReference type="InParanoid" id="A0A6P7GEJ1"/>
    <dbReference type="OrthoDB" id="19729at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF12">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028142520.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13398" checksum="218FD65006D0E35F" modified="2020-12-02" version="1">MSASPMARQAVESKAIPIRRVLINDHSELPAHYSSTPGGTLFSTTPGGTKIVYEKSVLLNLRNSPISKTPPQFEIPDTILGGSAKNVVRKQNHSRPLPPSPRKSQPEINNHNTSEDQFDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGL5</accession>
    <name>A0A6P7GGL5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import receptor subunit TOM40 homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114342305</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148909.1">
        <property type="nucleotide sequence ID" value="XM_028293108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGL5"/>
    <dbReference type="FunCoup" id="A0A6P7GGL5">
        <property type="interactions" value="1986"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641872.1">
        <property type="protein sequence ID" value="XP_050497829.1"/>
        <property type="gene ID" value="LOC126878993"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GGL5"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000005">
        <property type="entry name" value="mitochondrial import receptor subunit TOM40 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028148909.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="34769" checksum="11E1C604038A2420" modified="2020-12-02" version="1">MGNVHAYSSNPPPPPPPSTTFPRKKDTDPAASPPEVIENPGPLEEIHSKCKNVFPTCFEGARVMLTRGLSNHFQISHTINMSSVTPSGYRFGATYVGTKQISPTEAYPILLGDIDPSGNLNATIIHQIQPNLQTKFGAQVQNSKFQVGQLTMNYKGSDYTASCTVANPDVINSSGIVVLHYLQAVTAKLALGTELAYQKGPSIPGGEIALLSAAAKYSTDNAQISGTLGVQGVHLCYYQRASKQLQIGVELEANHRMQEAVASVGYQVDLPKSEVVFKGHIDSNWSVGAVLEKKLTPLPFTLALSGLMNHNKNQFRLGVGILIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIG6</accession>
    <name>A0A6P7GIG6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger HIT domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114337356</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028143570.1">
        <property type="nucleotide sequence ID" value="XM_028287769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIG6"/>
    <dbReference type="FunCoup" id="A0A6P7GIG6">
        <property type="interactions" value="920"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287769.2">
        <property type="protein sequence ID" value="XP_028143570.1"/>
        <property type="gene ID" value="LOC114337356"/>
    </dbReference>
    <dbReference type="GeneID" id="114337356"/>
    <dbReference type="KEGG" id="dvv:114337356"/>
    <dbReference type="InParanoid" id="A0A6P7GIG6"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028143570.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15637" checksum="8501B176BA2AE519" modified="2020-12-02" version="1">MNKICEICQKEARYKCPICLIFYCSVPCCKKHRENKCNVLQRDEETEEANLIVKRRKIETVTEDTVADDRLKLLATNEELNNLLANSHLRNLLVTIDQTENADEVMQKAMQEPIFVEFADACLKVVENKTTEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIS8</accession>
    <name>A0A6P7GIS8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein OZF-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114338711</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145113.1">
        <property type="nucleotide sequence ID" value="XM_028289312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIS8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289312.2">
        <property type="protein sequence ID" value="XP_028145113.1"/>
        <property type="gene ID" value="LOC114338711"/>
    </dbReference>
    <dbReference type="GeneID" id="114338711"/>
    <dbReference type="KEGG" id="dvv:114338711"/>
    <dbReference type="InParanoid" id="A0A6P7GIS8"/>
    <dbReference type="OrthoDB" id="6408474at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028145113.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="58939" checksum="70B183A41CA88094" modified="2020-12-02" version="1">MEVKQEQNNFLDEDCKIKIENINLSHDGLYHSVKLEVKDELSPADSPNTNTINYCGDGYSSDKLKVETIVKDIKLEETEAEPQQTENGCLEKNTETIKTFVQPCHKEQNTGAKKSYQCEICFKPFSEKRNLKIHTMTHTEEKPYKCEMCSKSFSYVCLLKAHIRKHTGEKPFQCEICCKSFSQKGELKSHQVTHTGEKPYQCNICCKSFSHSSNVKSHMRIHTGEKPYQCEICFKSFSENWYLKRHIKKHIGELQYQCEICSGSFHTESILKTHMRMHTGEKPFQCEICLKSFSQKGELTRHNLTHTGEKPYQCNICCKSFSHSSNMKSHMRTHSGEKPYQCKLCFKSFSQNWYLKTHIKKHIGELKYQCEICSGSFHTESILKAHMRMHTGEKPFQCEICLKSFSQKGELTRHKLAHTGEKPYQCNICCKSFSHSSNMKSHMKTHSGEKPYQCEICYKSFSKTNDLKRHLRTHTGEKPHQCEICFKSFSQNWYLKTHIKKHTGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKQ5</accession>
    <name>A0A6P7GKQ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MARCH3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114337979</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144365.1">
        <property type="nucleotide sequence ID" value="XM_028288564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288564.2">
        <property type="protein sequence ID" value="XP_028144365.1"/>
        <property type="gene ID" value="LOC114337979"/>
    </dbReference>
    <dbReference type="GeneID" id="114337979"/>
    <dbReference type="KEGG" id="dvv:114337979"/>
    <dbReference type="InParanoid" id="A0A6P7GKQ5"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028144365.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26225" checksum="96744E5F4CFAA248" modified="2020-12-02" version="1">MSSIISLVCRICYDSEKDEDLITPCDCKGTVAFVHRSCLETWLGESNTASCELCHAVFQTERVPRYTSGISIWHWCWKSNGSAQDVRSDIVACTIITPLTIIITYVCLFSSEYYNQIKFASVPAARWTSVTMLIMIGIMLIAYYMWVYSTIRMHARRWYNWWQRTCNVRYIPPGTAIVIGGTDEEAEVLEQNSTTIVSIALNNIINNISNLDERSLNSSSVTNNINLTNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQW5</accession>
    <name>A0A6P7GQW5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114339693</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146165.1">
        <property type="nucleotide sequence ID" value="XM_028290364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQW5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644201.1">
        <property type="protein sequence ID" value="XP_050500158.1"/>
        <property type="gene ID" value="LOC126880376"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQW5"/>
    <dbReference type="OrthoDB" id="10012027at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028146165.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40405" checksum="D642F68FC3745AE3" modified="2020-12-02" version="1">MATNNINNELKNAVYSRNLEQIKALLCAGANANFRVCRSENTLLHTTDSVEVAKELLLGGADVNARNTYNDTPLHSAIIGANKLELVRELLKHGAYVNATKRKDNTPLNLAVRKSHKNLEVVKELLKYGADINIRNREKRTLYHNEDSSPLDNAVGDLECAKLLIKFTLVRNFDKNYRKIIDLSPYTEWSNYSKLSSYLDDCVCEMLQMKADEIKDCVPLYEFVTNNNIVHVLYSNQLAAGLAKIDYSIRYPIYHDIISEQVKALLERTDLLKKLSQIQFYTKLDVADQDDEEKKIILDHDSTYNIAQYLTNDNLLNFITAFDDSNKRTLEVEPNTKLYETSISDDTKRARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6K2</accession>
    <name>A0A6P7H6K2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Thioredoxin, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114346811</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153348.1">
        <property type="nucleotide sequence ID" value="XM_028297547.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153349.1">
        <property type="nucleotide sequence ID" value="XM_028297548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6K2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650418.1">
        <property type="protein sequence ID" value="XP_050506375.1"/>
        <property type="gene ID" value="LOC126884477"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF5">
        <property type="entry name" value="EG:132E8.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028153348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028153349.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14494" checksum="D4C5F09D7A35F18D" modified="2020-12-02" version="1">MNKIVISLLTKRTFSSSNVLKRIINITNNDEFLAKVMHSSNPVIVNFHAEWCEPCHILTPKMKELIEPKTNIDLAIVDVEHNAELVDTFEVKAVPAVIAVRDGIVVDKFIGLVDANMIETLIEKLDQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDB8</accession>
    <name>A0ABM5IDB8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130323.2">
        <property type="nucleotide sequence ID" value="XM_028274522.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274522.2">
        <property type="protein sequence ID" value="XP_028130323.2"/>
        <property type="gene ID" value="LOC114326224"/>
    </dbReference>
    <dbReference type="GeneID" id="114326224"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045827239" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130323.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="89" mass="10386" checksum="F92481A65402A01A" modified="2025-10-08" version="1">MKFSVRVFVIFFINISLAWATWIQQDTYHCDESNNEEYDCIFDCPLKCDTLYERCVTTSCLFCQPGCYCKKGYARRNDGCCIPACECFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDF7</accession>
    <name>A0ABM5IDF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130392.2">
        <property type="nucleotide sequence ID" value="XM_028274591.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274591.2">
        <property type="protein sequence ID" value="XP_028130392.2"/>
        <property type="gene ID" value="LOC114326282"/>
    </dbReference>
    <dbReference type="GeneID" id="114326282"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130392.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="685" mass="75999" checksum="720308274246F2EC" modified="2025-10-08" version="1">MECGCANNFLGPSLDQTCGGSIFLFMTLLDTFIRNACDISEACERVIPRRRPDHEYDFVVIGGGSGGATAAGKLAQVPGWKVLLIEAGNDEPPGSQVPSMVVSYHGNKYVDWKYKTEPEKVACQGYPEKRCSWPRGKVLGGCSVINGMMYTRGTPKDYDSWAAAGNEGWSYRDVLPVFKRFEDNKEIGTLVEAEYHGTGGPLTTSRFNDQPELAYDILTAAKQSGQKVNKDLNGRDPSGFAIAQSNTRNGVRLSSARAYIRPQRYNTNLHVMLNSTVTKINLRKDGKQKIVDTVEFVYEDKKYTVKVKSEVVLAAGAINSPQILLLSGIGPKADLDKVGIQQVHDLPGVGKNLKNHVTFYITYLLKKQKDFVDLDWATAMNYIVNKKGPMSSTGMSQVTARINSKYADPSGENPDLQIFFAGYLAKCAKTGEVRALEDPEKPDHPKTLTMSPVTLHPKSRGHVTLKSKNPLDAPLMVANYLSEPEDVQVLVDGIRVIQKLMNTTVMKQKYLPELIKEDYGECNKKYKYDSDDFWQCAIRYYTGPENHQACSLKMGPLSDPMAVVDNRLMVHGIDGIRVMDASAMPILVSGNTHATIVMMAERGVDFIKDRWKPQQIGNRFGNNFPISGNNYPVQNQNPPDNNGINHVDIGDRFWDNHPSWNPNSGGVKGHSLHHYHGVKNGVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHQ9</accession>
    <name>A0ABM5IHQ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division control protein 45 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133094.2">
        <property type="nucleotide sequence ID" value="XM_028277293.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277293.2">
        <property type="protein sequence ID" value="XP_028133094.2"/>
        <property type="gene ID" value="LOC114328442"/>
    </dbReference>
    <dbReference type="GeneID" id="114328442"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133094.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="64489" checksum="AC916AF9FC47AE88" modified="2025-10-08" version="1">MYVDDIKNDFYEYLSGKRIFLMIHYDIDSICACKILQSLLRYKHILYSLAVIKGKQDIKTAYRENCNDVKYFILLNCGGTIDIVEELEAEEDVTFFILDSHRPTDLCNIYSNGQVRILSTPEEDIAVPEFHDVFREESDDEEDDSDDESQAAKRRRLDEEQLIKRREKRLWEENRDKLIFEYSQFTYYARASAIRIFELAWKLNKDDKDLLWLAIVALTEQMLLGKIESTLYTLEIGPLQAHAVRLQNKTNDTDVMTSLKITFENDLKLTLYRHWSVKSSLKYSMFPAVKMKLWSLKGDKKLHELLADMGFPLIQSQQAFKSMDLQLRKEFHESLEKLSEKYGLQDIVYASFVLQYGYRNRYCAADIVFALLAILESSPRDKKPEELFNLTLDCLSRTKREILSSAIDRAKDISKTIFKTVQSALDMKQIITAGPFVYFIIQEGSPNWHMFSHQHVLLMLAHFLLRAYVAMSRNRKASTLPLIVSAPKNLESGTCILLGIPPLCENSPKNFFGKAFEQAAERVNCDASCDFIDTSYFEIHAKDRTRFFDALTALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJ25</accession>
    <name>A0ABM5IJ25_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 9e2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133915.2">
        <property type="nucleotide sequence ID" value="XM_028278114.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133916.2">
        <property type="nucleotide sequence ID" value="XM_028278115.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278114.2">
        <property type="protein sequence ID" value="XP_028133915.2"/>
        <property type="gene ID" value="LOC114329101"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278115.2">
        <property type="protein sequence ID" value="XP_028133916.2"/>
        <property type="gene ID" value="LOC114329101"/>
    </dbReference>
    <dbReference type="GeneID" id="114329101"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133916.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="61022" checksum="F314BC204D963AD8" modified="2025-10-08" version="1">MFLILGVILLTTLIYYYMINPLSHWRERGILQKGVLESFHFSWFGIFYRVSMADNIIKAYNDFPGTRYYGLYQFNVPTMLLKDVDLIKQMVIKDFDHFNEHRAFAREDVDPMWAKNLFSLTGNKWRNMRSTLSPSFTSSKMKGMFVLMKANAERFVNFYLNQNKEIIQVEMKEVSTRYSNDVIASTAFGFDCDSLAEPNNEFYIMGKNLTAFGRFSTIIRFLFSMFLPNVAKLFNIRIIKQEVGNFFTKIIEDSIKMREQKGLVRPDMIHLLLEARKGNSKADDQHTTADTGYATVEEHLKTEIKTDITNEDIVAQALVFFFAGFDSSSNLMSFMGYELCANPDIQDRLREEIKETLENCNEKLTYEALVDMKYMDMVVTETLRKWPAMPAMDRICTKPYTIEPVLPEEKPVQLIPGDIVTLPIYSIHHDPELFPDPETFDPERFSEENKADLKPYSYMPFGLGPRNCIGSRFALLETKILFFYILKYFKIVPVEKSDIPIKLDKSVFQFVPSKGITVGFERIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILC4</accession>
    <name>A0ABM5ILC4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028135561.2">
        <property type="nucleotide sequence ID" value="XM_028279760.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279760.2">
        <property type="protein sequence ID" value="XP_028135561.2"/>
        <property type="gene ID" value="LOC114330417"/>
    </dbReference>
    <dbReference type="GeneID" id="114330417"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044949516" description="CLIP domain-containing serine protease" evidence="8">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="10">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="149"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135561.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="422" mass="46829" checksum="8C0F56F982C1186A" modified="2025-10-08" version="1">MIVRLKLLCLFFLCIVNVFSGSNFTIINNATTNSAISAVFNESTRTVISTNAVTNLSVSLRLPTECGTPNGDPGWCLEIQDCPLLLKQITNIDARPFLLASRCGPPNEDSRRPKVCCGKYDKYQDPSLDEINIFPKRCGHQKHIMQSRILGGTTASIGEFPWMIRLVHQNDRGYKTFGCTGFLIHTKYVLTAAHCVHGKFIQFRGPVFLVQMGEHNTETKIDCSSIGTNCADPLQISRVGQVIVHHGYDVDSPGHYNDIALIHLKKAARITEFVTPICLQMDNVVPNRYYISGWGKTETEAFSKIKMKLEIPPYGRVQCVEKYSIVSIEVAESQICAGGEDRKDSCTGDSGGPLMFENGTHWMAAGIVSYGLGCGTEDWPGIYTNVSHFLPWIKEKIFENSLVNTKNPNKGVKISNRNKPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IME4</accession>
    <name>A0ABM5IME4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136432.2">
        <property type="nucleotide sequence ID" value="XM_028280631.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280631.2">
        <property type="protein sequence ID" value="XP_028136432.2"/>
        <property type="gene ID" value="LOC114331147"/>
    </dbReference>
    <dbReference type="GeneID" id="114331147"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136432.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="629" mass="73455" checksum="35A46BFEFC943507" modified="2025-10-08" version="1">MEVKTEIKDEFVESDPVSYIESQLSSSTNLGYLKNEPQDNSGMEAKTEINEKFVESDLSYIESQLSSSINLEDLKNEPVENPAMEIKAEIKEGFVEVDPRYIMSQLSTSTHFEDLKNKSEGSLEEKNTLANMEKLSLRTCNKKCVMQPDEEQKCEICIKQLGHKSYLNTDMKICTGKKRCKCEICFKQFSDKYTLKRHLRTHNGKKPYKCEVCLKLFSEADSLKKHFRVHTGEKPHKCEICFKQFSEASNLKTHLRVHTGEKPHKCEICFKQFRANNFRRHLQVHTGEKPYACEICFKSFTQAASLKDHLNIHTGEKSYKCEICFKQFNHSSNLRRHLKVHTGEKSNKCEICFKQFTHAFSLKIHLQMHTGQTPYKCEICFKPFSLSNDLKKHLRVHTGEKPYKCEICFQKFTRADSLKSHLSIHTGEKPYKCEICFQQFTKADSLKKHLRIHTGEKPYKCEICFQQFTRADSVKSHLSIHTGEKPYKCEICFQQFTHADSLKKHLRIHTGEKPYKCEICFKQFTLAGTLKSHLRIHTEDKPYKCEICFKQFTQASGLKRHLRVHTGEKPYKCEICFKQFTQAYRLTEHLRIHTGEKPYKCEICLKSFSQAVNLKKHLRVHTGQKTLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INP6</accession>
    <name>A0ABM5INP6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137532.2">
        <property type="nucleotide sequence ID" value="XM_028281731.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281731.2">
        <property type="protein sequence ID" value="XP_028137532.2"/>
        <property type="gene ID" value="LOC114332028"/>
    </dbReference>
    <dbReference type="GeneID" id="114332028"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038757">
        <property type="entry name" value="BRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259:SF1">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137532.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="352" mass="40633" checksum="3ED2C2F24EA3E361" modified="2025-10-08" version="1">MSKSELLKEYKKNVVQIKKHAKNLSLSEKEVNILFEQSFLELRKEQNGTNVPKPIKAQSLCTSIRNIFVLFTTLSFFIYILLNVHQPTSSIVLRNVQGLTYPTLKFIRFLSVPIIRLFPSLTDLYDETCLIENPYFYVADMECWPCENVFAVLNISSMEESYLKSESGTPFIVKSNQKTVTLKTLQQTYKQNRVLLDSETRRLQSTNSSITTLRDLFGSDDNIFLSNLNTHISWRITKMASARIIRQVFPKPFFLPERSGQSVERFVMLDGHTAEPYVLPNTECSYVFLIQGSGERSIVLKPSKECSNNCRTVSVVLKPSYILWYNWWYWRPISLPVTNATGPSITYINSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR33</accession>
    <name>A0ABM5IR33_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139268.2">
        <property type="nucleotide sequence ID" value="XM_028283467.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283467.2">
        <property type="protein sequence ID" value="XP_028139268.2"/>
        <property type="gene ID" value="LOC114333572"/>
    </dbReference>
    <dbReference type="GeneID" id="114333572"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043536">
        <property type="entry name" value="HCF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059124">
        <property type="entry name" value="Kelch_HCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003:SF1">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13854">
        <property type="entry name" value="Kelch_HCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="349"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="847"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139268.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="980" mass="108816" checksum="D06BDB66AAC668B7" modified="2025-10-08" version="1">MDKALKWKLVEDPTGPHPRPRHGHRAVIIKELMVVFGGGNEGMCDHIFVFNTATNQWFVPITKGDVPPRCAAFGFVADGTRLLVFGGVEEYGKYSNELFELQVTKWEWKRLKPKGTKIGHVPCPRLGHSFTLVNSKVYLFGGLTNYRTDPNKLVPRHLNDLYILDIRSNPMQWDFPQTNWAGPTPRESHTGVGYVDKNQDSFLIIYGGMNGRRLGDLWFLQTETMTWMQPQVFGLAPLPRSLHTSTLIGHRMFVFGGWVPAVPSKDENALEKAWKCTSTLACLNLETMSWDELNIPRESELDLPCPRAGHCAVGISTRLYIWSGRDGYKKIGKNQVCCKDLWYIDVDKPPAPSRVSLVKAGINNLEVNWTGAISVHTYILQIQKCEISPLSESKIPASSTALVSSFLTSKTTAVSLQRNITTNDMTSVNLPKGCNIVQTKTHILPQMRKHSIVKISPISLVNKSLQTIKVIPHQINTATGKLFPFKMTRKIATIGNQGTSKIAQTNKYIANSLSMVNVQSPRTANLSKSTIQKYDSTQSVAFTTPATTIPVVSSVTTLSRAIAPVQTQSYTLPLDSITKEVEESLDPKITPESETKSEDEVIPEKIEKTEDSLETNVATNFASKLETGERSDIKDKLESEVKFDNNEQSSGTTSLEENQRNLDIDVTAKQEMESKKESDTGENSFDNTGKSETGSCMESVVDPSYLKDHNQNINILKPDDLTSEFKKAPVTTTDDPLATLASVALDHYEELKRSENHAQGPEQPSKDIWYTVRIIRGNSCDVRNYFLLKDQDADLTLDTLPYTVPDPSGFSLEPGTAYKFRVAAINFFGRSDWSEVSEYKTCVSGVPGAPSAIKISKLVDGANLSWEPPSASHGEILEYSVYLAVRAKYKVNPSPGQLAFVRVYCGPNSKCMISNASLSTAHIDKTTKTAIIFRIAAKNEKGYGHAKEVRWLQDPSSKSKRLAESQPLAVKKVKFGKEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUJ1</accession>
    <name>A0ABM5IUJ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142506.2">
        <property type="nucleotide sequence ID" value="XM_028286705.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286705.2">
        <property type="protein sequence ID" value="XP_028142506.2"/>
        <property type="gene ID" value="LOC114336350"/>
    </dbReference>
    <dbReference type="GeneID" id="114336350"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142506.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="501" mass="55356" checksum="668CBFBA7F65A50A" modified="2025-10-08" version="1">MLTGWRLTISKLFLIPQRYILGIMGFLAVVNAYSLRVSLNIAITEMVAPSSSSFYDPDSCPAENANKSHNSVTNTDLLYDWDETTKGLILSSFFWGYVVTHLPGGVLAEKFGGKYSLGLGILSTAVFTLLTPWVIRTTNGNWKVLVALRVIMGLGEGTTYPALNALLAKWVPLHERGKIGTLVYAGSQIGTIVSNSISGALINATRDWSSVFYVFGAAGVIWYILWQLLCYSEPESHPFISDDEKTYLKKELENVSEEKGKIPWKDIFTSPPLLALVAAQIGHDWGFFTMVTDLPTYMSDVLKFNVKENGIWTSVPYIVMWLVSMGSGWLCDWLVSAGYMKITFARKFFTSIASVGPAIFIMAASYSGCDRYLTVAMFTVAMGFMGPFYCGMKVNALDLAPNYAGTLMAIVNGIGAFTGIIAPYLAGALTEDHTLKQWRTVFWITFAIFMSTNIIYCLFGSGEEQHWNDPAKLKQQELDSKYGSIANQSSKSESTLENSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWV8</accession>
    <name>A0ABM5IWV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145972.2">
        <property type="nucleotide sequence ID" value="XM_028290171.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290171.2">
        <property type="protein sequence ID" value="XP_028145972.2"/>
        <property type="gene ID" value="LOC114339506"/>
    </dbReference>
    <dbReference type="GeneID" id="114339506"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010441">
        <property type="entry name" value="CH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052111">
        <property type="entry name" value="Spermatogenesis_Ciliary_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509:SF9">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12509">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06294">
        <property type="entry name" value="CH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145972.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="227" mass="25948" checksum="7E500D817A03E22B" modified="2025-10-08" version="1">MDIDYEELYKWVDNHTISRPKRNLNRDFSDAVPLAEILKQHYPRLVELHNYSPGNAFSNKMINWNTINKKVLNKLGINLNKKKQEDLALGKPEAIAKLLNMIKTKVESKSARGDEKDQGNKVYYIENCNNLSSAEDIVPIKVNNGSEMVDKKLVPAELFENMEKELAQKEEAVNLLTGKVEHLEKLIAIKDERIKDLTTQMQAVINSTSGSTANLMSPKTRFFKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZC2</accession>
    <name>A0ABM5IZC2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Circadian clock-controlled protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151872.2">
        <property type="nucleotide sequence ID" value="XM_028296071.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296071.2">
        <property type="protein sequence ID" value="XP_028151872.2"/>
        <property type="gene ID" value="LOC114345250"/>
    </dbReference>
    <dbReference type="GeneID" id="114345250"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF14">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046764745" description="Circadian clock-controlled protein-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151872.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26892" checksum="108195A408BB9EA2" modified="2025-10-08" version="1">MQLFFYLFLFGSVNVAIGRKLPDFLEPCQQSLKEVGPCILKNVELVRPRLPNGIPELLIPATKPLTLAEATLKTSGFVITFTDIKVFDLDKIDVKEFQFNTETLKIKISVVFPALVGISKYKLKGRVLVLDVDSYGDFYGNFSSTSATVEGQGKLVTKKGKQYLNIDDASIDVYVETAFVSFAKLFGDNEELTINANKIINENIREILDELHPISVQTIKGVLLGIAGRIFNRFSFAELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZH5</accession>
    <name>A0ABM5IZH5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152459.2">
        <property type="nucleotide sequence ID" value="XM_028296658.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296658.2">
        <property type="protein sequence ID" value="XP_028152459.2"/>
        <property type="gene ID" value="LOC114345846"/>
    </dbReference>
    <dbReference type="GeneID" id="114345846"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19342">
        <property type="entry name" value="Wnt_Wnt10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF98">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046531241" description="Protein Wnt" evidence="10">
        <location>
            <begin position="25"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152459.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="378" mass="43442" checksum="B348741E168441A0" modified="2025-10-08" version="1">MTIICSVATIFALFVILFSWMLEAKVSVKQQTFSYYDMYMDTTICRTVPGLTKEQIELCYQQPDATTVALEGLNQAVKECQYQFQDSRWNCSSLETRGQNPYISSILKKGYKETAFAHSMTSASVAISIARGCSAGILMNCGCDSKIYKIRKPREMVKTDWRWGGCSHNIRYGLKFSKMFLDSREKAEDMQSKINLHNNQVGRRAVSNNMKLVCKCHGMSGSCELKTCWRAAPDYRAIGKELKERYNQAVLVDQTNFGKKNLRKFNMINQKAHRKNSKHKQWTPRKNKHKRDLSYDLLYYEKSPSFCEKDPGTDIPGTSGRICNITSTSTDSCENLCCGRGYNLIKKRKVERCNCKFIWCCQVECQTCSHEEWISICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZY5</accession>
    <name>A0ABM5IZY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154517.2">
        <property type="nucleotide sequence ID" value="XM_028298716.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298716.2">
        <property type="protein sequence ID" value="XP_028154517.2"/>
        <property type="gene ID" value="LOC114348084"/>
    </dbReference>
    <dbReference type="GeneID" id="114348084"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF55">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154517.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="410" mass="48029" checksum="58C1A2116866A13E" modified="2025-10-08" version="1">MAEENLREFIREIFKDYEVTKESITSLTKPGDNFLSIMLKVEVILKKRDDGSEKKLNAVAKCVKNSNDFVKSLFPTAFKNEIIFYKEIVPVLQNFQQERGIEDVLDMFPEFYGARINNNGSDEVDDTAVVLLEDLKFDGYINVDRHEGFNLAEAKIILKDICRLHATALGLKFSQTELFDEKIRKNCKKAIPLPKPSDKERYRQPLEVFFNILADYEECRPYISNLKIQFDNMRGAINDFFDKPAREPFATLVHCDLWVNNTMQLFQGGKIKKNKFVDFQLYYYQSPVSDVLFFLWSSVHLDVLKQNFDELLTYYHTEFTDQLRRLNCNTNLFDIDKFWEELDAVAPTNFIDIMYMTMFVVFGKKDRGDDELETDGIKGVLKEDVPKAARDKIAFMVNEYGRRKWIEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGW0</accession>
    <name>A0ABM5JGW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497179.1">
        <property type="nucleotide sequence ID" value="XM_050641222.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641222.1">
        <property type="protein sequence ID" value="XP_050497179.1"/>
        <property type="gene ID" value="LOC126878474"/>
    </dbReference>
    <dbReference type="GeneID" id="126878474"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047237347" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="143"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="389" mass="42729" checksum="51A8B731CCC851D1" modified="2025-10-08" version="1">MKHKLIFLFVYFVFYNDVYAQVGDRCTFKGTTKRGVCKEITKCPAAEAQAKQGTDDVTLCGFANDLITAIVCCEVTVEPNDNLLPADFDTNGETSPPGKMSERKCQEYSKAITSEVQVLSLVSDATPMSYRTPKCDYNTVPLIVGGTPAEAGEFPFMVAIGFNTTSDRWRCGGTLISTRFVVTAAHCCYTRDAGKPSVVRVGELDLASDQDGSVYADYLISRVIVHPGYSAPYKYNDIALLETQQPVVFTNFTRPACLNLNHNVAQSQAIATGWGKTDFAGDASDRLLKVTLNLYDNQRCQRTFPPNNKELPRGIESTMLCAGHLEGGKDTCYGDSGGPLVVTKKGNMCQFFLVGVTSFGKLCGQKNTPAIYTRVSEYIPWIERIVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI75</accession>
    <name>A0ABM5JI75_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497639.1">
        <property type="nucleotide sequence ID" value="XM_050641682.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641682.1">
        <property type="protein sequence ID" value="XP_050497639.1"/>
        <property type="gene ID" value="LOC126878787"/>
    </dbReference>
    <dbReference type="GeneID" id="126878787"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="304" mass="36310" checksum="9A7357129232D3F5" modified="2025-10-08" version="1">MSDLCNISQDGIKSVNSTFLQNQSFLYKENIKLQDDIVRLSQQLEEIRSLKMNDDLFQYFQKEKENLLTLNNTLRENIRHLKTPSKFGDHEAKNELRDTVYQLDKIIEKVRRNDKFEIKTQKNNTEEVIKSLTEKLEEEQRKYEESNEALRKLREDDEKYMLREKILDMKQLFTDLEVENTKLKYENEQLLQDIEHYKKQLDEALEETKASAKQCCALDDEKELLKKTISNLENERIRIKKAMIEEMNEANRAKRVSVDTEIALQHISEAYENKRKEIKSLMEQLEDAENIIKEFKQQINIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ00</accession>
    <name>A0ABM5JJ00_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin synthase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497915.1">
        <property type="nucleotide sequence ID" value="XM_050641958.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641958.1">
        <property type="protein sequence ID" value="XP_050497915.1"/>
        <property type="gene ID" value="LOC126879065"/>
    </dbReference>
    <dbReference type="GeneID" id="126879065"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF27">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin synthase-like" evidence="10">
        <location>
            <begin position="342"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="471" mass="54143" checksum="67CDF01E921DD5DD" modified="2025-10-08" version="1">MTHGCGSDDEVDSKSCGLPQTIGPFRNLVDTEHCGLPWTTISSEHLILAYPQHQFRLLAELQSKKQEDGNGMILEPKFVDYGSIHPTSADISHHQAQQHNPHGVLNPRTSTLLPINDEPANTSHQSKMTQGDLYQRQPLLPNPNKGDKWGHSAHSTNSNEYYDEEEIVQKSSERNGHISIDLPPPVREEPRFPQERCKTLLAAIVMFFSFVLTLTSLSLVHERVPDKEVYPPLPDVFLDNVPAYNWALDVSEYIIIFSVNTSLIAMIFHKHRFIVFRRIFLLMSLLYLYRAITMYVTVLPLSNRNYPCSPKANGTSPLMIVKRVAKLMSGMGLSVNGQHVYCGDFIYSGHTVILTFTFLLISEYTPKKLYLVHWLYWILSCLGVIMLELSHGHYSIDVIIAYFVTTRLFWTYHTLANNSILKQHSPSNLLGREWWFSLFLYFEGNVSGPLPRQYNWPFPWPRRWHLKSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJA2</accession>
    <name>A0ABM5JJA2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050642062.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050498019.1"/>
        <property type="gene ID" value="LOC126879116"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
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        </location>
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        <location>
            <begin position="464"/>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="663" mass="77591" checksum="812768190D569691" modified="2025-10-08" version="1">MSFIFTTYMTFDKSKHKPQSVKKSLEKPRYKDTEKPYKKPYSIQVFQNSFGFFLTINIFPKYYTNQMEVNQEVMENTCKLEIDNNEVDDNDALLLTFKTEIKEEPEIDTTNSDDFNCNKKHPVKTEIESHEDAVCLLQVKEAHESFKCEDTLTDENNELKNHLINNQLNQCTTDVRKVTIVEKPFASEKKNFRRHLIVHTAKKLFGCEICTKQFSQSSYLKIHMMRRHNTGEKPFGCEICTKQFVTHNELKLHMTVHTGERPFICEICTKQFSRSISLKVHIMRKHNTGQKPFGCEMCTKQFVVHNELKRHMAVHTGEKPFSCEICPKQFSRSSVLKKHLSIHSGEKPFGCEICKKQFSRRNYLKDHMLRIHTDEKPFGCEICTKQFVTHNELKLHMTVHTGERPFSCEICTKQFSKSISLKVHIMRTHNTGQKPFGCEMCTKQFVTHIELKRHMAVHTGEKPFRCEICTKQFLQSSHLKVHMMRSHTGEKPFECEICTKQFVAHSGLKLHMTVHTGERSFRCEICTKQFSQSISLKVHIMRKHNTGQKPFGCEICTKPFVTHIELKRHMAVHTREKPFSCEICTKQFSRSSVLKKHLRIHSGEKPFECEICTKQFVTNHALKIHMTVHTGEKPFACEICTKQFSRRPHLKRHMVVHTEPKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLN0</accession>
    <name>A0ABM5JLN0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PDF receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_050642878.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050642879.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050498835.1"/>
        <property type="gene ID" value="LOC114327758"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050498836.1"/>
        <property type="gene ID" value="LOC114327758"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
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        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
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        <property type="entry name" value="PDF RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
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        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-0675">Receptor</keyword>
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    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="210"/>
        </location>
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        </location>
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            <end position="351"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51718" checksum="73268E1642A3FA8B" modified="2025-10-08" version="1">MAYNSSGNSTIDGWCPHSCDIYLCWPPTPPGKNATQKCPPKEGLLKNGIAYKYCSPTGTWETRNFSNMSYTHYDNCFLSQLQDLMKMCNEFGDTTCQQIARITRCIEMVGLSFSLVSLLIALYILFSYRVLKNNRTKIHKNLFISTLLQVIFRLIQYIDQELDNHDKFLNNGYLYQIDIALLEYSKTAMFLWMFIEGLYLHNMITVTVFQEYNYIKIYCYLGWIIPALMTAGWLIAMLIEEAEWLYYYFLSYYWILEGPRYAVIIINLLFLLNIIRVLIVKLRESHTSEIEQVRKAVRAAIFLLPLMGISHILFLQFRFNEAWKFAAWSFASYFLATFQGFFVAVLYCFLNGEVQTAIKNSFYLRMSLRNNDYTPCRNFALISLAPENGTIQNGETSKWVFCCKYKRPSADETEIRSSRDNWSSNHIVEETDTSLIHVPLTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMX2</accession>
    <name>A0ABM5JMX2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Helicase POLQ-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="RefSeq" id="XP_050499285.1">
        <property type="nucleotide sequence ID" value="XM_050643328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499286.1">
        <property type="nucleotide sequence ID" value="XM_050643329.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643328.1">
        <property type="protein sequence ID" value="XP_050499285.1"/>
        <property type="gene ID" value="LOC114330119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643329.1">
        <property type="protein sequence ID" value="XP_050499286.1"/>
        <property type="gene ID" value="LOC114330119"/>
    </dbReference>
    <dbReference type="GeneID" id="114330119"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="522"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="745"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1305" mass="146841" checksum="FCE604448B7F0AAD" modified="2025-10-08" version="1">MNESNKKQIMFNMIQKSKEENQNALQNRKDPRKKSIYFQKSSSGVFSSIDSCEDYVIETNTSVPTTSSDKRNIEFSLPNLPGSKKLKLDNTAKIEEPQQCLQDTLDSVNISKLLEKSSPAEKNEYDAFANYLSGVTPKNNASKEKGLKKDVNSSISTSNEDLFGSQFLDTQTLNQIDINIEKNNTSLNNNVKQVCANDDNKQLQFLDTQTLNQIDISIEKNNTPLNNNVKQICANSSINDDTKQSQFLDTQALNQIDSTIEKNKKPLNNNKQICANSSVNDDTKQSQFLDTQSLNQIDSTIEKNKAPLNNNKQICANDSVNNDIKQVQKEGDDHKFAVPLKLCFKERIKSKVSVNETLIDKEIGERTVLFENEKVTTEYRREVDQIFEQIENSICAMGEESSKYNIPEEFLDIIFNDDFETSPDKKEITEKPSTSSDSQLSTSRMDLSFGSLIKKALIKNSTKSPGERKKVVDVLNLSINESKSVFVPLGPFYGLPLKVKQLIQQYKGIEELYDWQDECLKLPAIESKRNLIYGLPTSGGKTLVAEILMFRELLCCRKNAIFILPYVSIVQEKVWAISPFGVALDFLVEEYASNKGVYPPRKRRRKNSIYIATIEKALGIINSLVETGRLHEVGLIVVDEFHLIGEDGRGPTLEASLTKIMYLKANIQIIAMSATIGNIADLCKFLNADVYTKNFRPVELTEYVKCTNKIAKVNWNYTNEEDILTDHKKIDFKYSDSIQKLDPDMLGGLVMEVIPNGSCLIFCPSKKNCENVANLLCKLCKPELKKYKQAEKEQLIHALKDEGGILCDILAVSIQYGIAYHHSGLTSDERRIIEEGFRAGIIYVICCTSTLAAGVNLPAKRVILRSPYIGKDFINLSRYKQMVGRAGRAGLGETGESILITQPPDLPKVVELMMSPMNRAMSGMHLAEGKGLRHLLLSCISLGIANTRAKLHEVTAHTLLSVQSDQQEVNIKQLTDKVIKNLFKLGALKELDVVYKEETNTKCDVSVRMDTSIQDTSLSENIITTPTKKRKRTIVLTDNTKLVVSELGCAAIKGGLELSRAHVLYEDLYEAQACLVLQGHLHLLYLVTPYETADQIKPNKQVYYEVFTRLKPSELRVAKTLGLNESVAVKMFSSNNPIKSVPERIINRFYVTLMLYDLWNEMPVFQVSEKYQINRGIVQNLMTIAATFASNVVNFCEELEEFWAYAFLLKGMSQRLSHCCVKELLPLMDLPAVKQSRAKQLYNAGFKTLQSIAKANVNDLVQNIEFMSTRVANQLIAASKMLLLEKVENLREEAEDVLDGADVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPB8</accession>
    <name>A0ABM5JPB8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499776.1">
        <property type="nucleotide sequence ID" value="XM_050643819.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643819.1">
        <property type="protein sequence ID" value="XP_050499776.1"/>
        <property type="gene ID" value="LOC126880120"/>
    </dbReference>
    <dbReference type="GeneID" id="126880120"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="88316" checksum="AD30F6E034A35554" modified="2025-10-08" version="1">MVKKPSTSKATACHICEKRFLATDIIVVDHDHFTGEVRGFAHQACNLNFRKVFVVPVAFHNFSGYDSHFMIIDLCKHGHLSLLPINKEKYISFTLHSDEHKIRLRFIDTMRFMGASLDELASLLDTSEKKILKQEFNSLDDDAFNLLTCKGVFCYDYVDSLEKLEETSLPTISHFYNKLCDEHISEQKYVHAQKVWSTFECKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYHLDPAWYYTIPGYTWDCMLRYTKCRLELLKDVDMILFIEKGIRGGISVCSNRFSEANNKYMSTYDPTQPSKYIMYLDVNNLYGWAMSEYLPFGGFKWIEDVTKFGVASKSTKLPKGHIDIMSIPNAAKEGYFFQVDLEYPRELHDKHKDFPFAAEHRIPPGSKLPKLLPTLFNKSKYIIHYRNLKQALSNGLILTKIHKVLKFNQSAWLRPYIELNTNLRAASKSSFEKNLYKMMNNAVFGKTMENIRRHRTVKICKNWNGRYGAKNLIASIRFHSRTIFSENLVAIELTKSVVCFNKPLYIGAAILDISKLCMYDFHYSFMLPTMGEENCMLLYMDTDSFIYELQCLDAYKEVLKAHNCKFDTSDYSENNPYMIERLNKKIPGLMKDEANGKIITHFIGLRSKMYTFKLQTTDEEREKERERLKLKLNKEQIDCGIQNLGITKKAKVVKYNVVKNIITFEDFENCLKEYKIKSTNQRCIRSYQHSVFSIEQTKTALSPYDDKRYLIPESFKTLPWGHCDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPM9</accession>
    <name>A0ABM5JPM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499897.1">
        <property type="nucleotide sequence ID" value="XM_050643940.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643940.1">
        <property type="protein sequence ID" value="XP_050499897.1"/>
        <property type="gene ID" value="LOC114334693"/>
    </dbReference>
    <dbReference type="GeneID" id="114334693"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF282">
        <property type="entry name" value="ETV5-RELATED PROTEIN ETS96B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="355" mass="40286" checksum="9070A5A34BB37018" modified="2025-10-08" version="1">MSQDQEVSATFSELGRLGCFFGSPFSSCYQQHQEHYKSSQAHAGSFPTDWREPWHQEGSSCGTDDSESYNTESEFQQTSPNGLKSEVVPTNLNHNSKLSNYNSSYNSSTNLDGIYTNGYHNTGCFYSNSLYGKISTSTVRIDPAITTLTVTPTSENHIPIKQEPADKEYKEYNEKSQEKQKEVLEYKNTAIPNSTGRRGSLQLWQFLVALLDAPDASAGCIAWTGRGMEFKLIEPEEVARRWGAQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAYGSNSDGTLKFQSAVRSDTSNIKSESQHHLAYSDMLNFYNCGIAHSYQHLHPYLQESKHTRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRV0</accession>
    <name>A0ABM5JRV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500668.1">
        <property type="nucleotide sequence ID" value="XM_050644711.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644711.1">
        <property type="protein sequence ID" value="XP_050500668.1"/>
        <property type="gene ID" value="LOC126880658"/>
    </dbReference>
    <dbReference type="GeneID" id="126880658"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="941" mass="106929" checksum="F3459C8D8A3E563B" modified="2025-10-08" version="1">MDNKEKHRKVLRTTFSKAAKELEDLLKDQKGEVRQIKISLDLLRQKMDDLRRIDEEIYDLLLNEDASEQDLLKEIEDSDSYIRKFADLSIQFEERVQPRIAASVEDGVASGTTGKSTGSLQGKRKFKLPMLEFKKYDGNIKSWLPFWSQFQKIHHDSDIDLSDKVEYLIQATVPGSRARQLVDSFPATGDNYTKIIDCLISRFGRDDLQIEVYVRELLKLVINNTSSGNKLDISLLYDRLETQLRALETLGIKSDKYAAMLFPLVESCLPADLLRIWQRFPEDVGSQTSINSAGISTIENRLKSLMQFLKNEVDNEQHVSLAIEGFGVSGTKSGNSKRNGPKKRMPEEEEPQFPSAMGLVNSHSTNHRCVFCENAHESSQCFKAQKLTYDQRVNILTEKGACFRCLKIGHQSRRCRGQLSCLLCHKPHVPLMCREFSMGKAKKEEENKIENDGQAVPKINQSLANSATTNVFLQTLRVKMNHLGKTRVVRALIDTGSQKTYILRSTARLLDYPCKRQINLVHGLFGGSELAQKHDCYDVNLSYNNYSCTFEALDQPVICSDISSVFNGPWMEELKKLNIEITDSGDTSPIEVLIGADIAGKLYTGRRHILGCGLVAVETLLGWTLMGKIPLDQQDNRTATTVSLFISNASISQLWELDALGINDPAERKTREETALAAKQLFFETVATDSTGRYETRLPWLEGHPALPSNYQMAKKRLDTTLKKINKDGYLEAYGQIFKEWLDENIIEEVFEDQPNRGHYLPHRPVIKPNSASTKIRPVFDASAKEKDKPSLNQCLEKGVNLIELIPAILLRFRRQEIGVISDIRKAFLQIGIHKADRDFLRFLWIDDAGKEKVYRHCRVVFGISSSPFLLGASLEHHFSLMLRRCASKLLNVSEDTILKLSHSFYVDNCVTSVANEQELRIFVEESNIIMAEDFLYKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSF3</accession>
    <name>A0ABM5JSF3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500866.1">
        <property type="nucleotide sequence ID" value="XM_050644909.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644909.1">
        <property type="protein sequence ID" value="XP_050500866.1"/>
        <property type="gene ID" value="LOC126880841"/>
    </dbReference>
    <dbReference type="GeneID" id="126880841"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045863487" description="DNA-directed DNA polymerase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1260" mass="146376" checksum="97D0BAD3A04765E0" modified="2025-10-08" version="1">MLAKLIQLIATILGSLSSNYNEEHYGKGLVECRKAIKMINNGMRFAKTIGEKQHLEAQMRQVKTLRNQLKAEQKKGAGLNTRPETAYKRVQWDDSLSAFNSRIRTGVISNLKHKDPGSFLNDCKAIFKRRIQNALKNDAAVKVNTAFGGEFEIVQGEKVLNDTKYFTTSNSAIYRDTNLDEWFEEKVMEPITAKLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSFVELPPQIMRKEACVNVKNDDEACFAWAVVSALYPANKHPQRVSKYPHYSDVFKLKSIQFPMTIKQIPNFEKQNNISINIYYLKKDKHFKILPTYLTKSRLTKHVNLLLIQDKYDESPTKYHYVWIKNLSRLLSKQLSKEEHKKYFCDRCLHYSRSQETLDKHTIDCLKQNETGINMPDKRNSIVKFKNFKNKVKVPFMVYADLESVLKPTVDPKKPQKHIPAAVGYYFKCSYDDSLSFYRSYRGSNCMEWFADEMNQLAEDASTVFLCPYPIHMSTDDERMFQAATYCHICEQRFSIKDKKVRDHNHMSPENNYRGAAHEGCNINYQDTHTIPVVFHNLSGYDAHFVVSGIATRMKGSIDLLPITKEKYISFTKHIDDARIQFRFIDSFRFMASSLEKLSSYLPKYPNLCAQFSSLPEEQFNLLTKKGIMPYDYIDSFDRFIETCLPSIESFYNNLEDKPCPRRHYRRAQEVWSSFNCSTLGDYVDLYMKTDILLLADVFEQFRSSCLKTYNLDPAHYYTLPGFTWDAMLKHTKQELELLTDQDMHLFVERGIRGGLSQVCSKRCVHANNTYIPTYDSSKPESYLMYFDVNNQYGWAMSQYLPYGGFEWVDANIDVLSVPDDASDGYFLEVDLDYPHHLHNHHNDIPFCPESLNPKTMKPPSRPRELTKLMATLSPKRKYIIHYRALKQALTHGLVLKRIHRVLKFKQSPWLKSYIDLNTELRKNARNEFEKNLFKLMNNAVFGKTMENVRKRVSIKLVTNWKGRYGAEARISDPLFKNVTIFNENLVAIEMRKDEIWLNKPIYVGMSILDLAKTTIYDFQYGYLADRFGENFTTCYTDTDSVIVEIRGKDPYETMKYDCHEYFDTSDYAADNPYNIPQVNKKIPGLMKDENNGRIMTDYIGLRSKLYTTKVLITDNDITKKRKILQNDEYDDDEIGAIIRNLGVTKKAKGVKMSVVQNKITFDDYVKCLDSYQSMSIQQKLIRSINHVVYSMVQDKIGLNSNDDKRCKVPDTCNTLAWGHYSINAATMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JST4</accession>
    <name>A0ABM5JST4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S8 pro-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500990.1">
        <property type="nucleotide sequence ID" value="XM_050645033.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645033.1">
        <property type="protein sequence ID" value="XP_050500990.1"/>
        <property type="gene ID" value="LOC126880952"/>
    </dbReference>
    <dbReference type="GeneID" id="126880952"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8 pro-domain" evidence="2">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127522" checksum="F8C3F32AF0EA1B56" modified="2025-10-08" version="1">MSCKHYLTSAILLQIGSLEGFYVFEHEHVRKRSLQASDHHHRKLNDEPQVHKQSLFRVRYSELDDVLESFNKNHQNIVTNLLNSEPTDAQLDSEDIIRSQFLNDYYQIKANFADLFENDDNSQKNEQNIAASNAVQPPSNVRLPQLELVKFSGEFTSAITFFDLFDALVHRRPNVDDTEKLTYLIQSLEGPPLRLAKSLPLARENYVRIYDKLKNRYLNKRLRAMAHWCKIEEAPATMFKNSDSYSNLIDTFSENLSALENLGYKISDFVLAYKILTKLDEETHQRFELLHGSSEMPTFIQLSDFLESQCISFDSSLLSPCSPKDSNRKNKSPSKHNANKNGSKVNNRYSFFSKPNTTTCLLCSADHHLKDCSLFLNKSSYERYNACKRMRLCFKCLEKHDSRSCSVTSHCGHCNSSHHSLLHFKKSESATHGATSVAAAPTTASSDAQVNTGTLSSHAASLGSVTSKNSSVLLATAVVEIMDGCGLYQPVRALIDGGSMTSFVSQSCIRQLGIRHSSATLSVQGIGAIKSTVVGRVDLQIKPVDRVDPIFNCEAFVLPKICEDLPVVSLDVGHWSYIANLKLADPRFHLSGKVDLLLGADIFSQLLLEGKVQTPRGMPDALNTVFGYVLMGPCSSVPMTSATSLFCHVDQMFSLEESVKQFWSLETVPEVECSAPEDILCEKNFVENVCRDGSGRYTVALPFRELSPVFPGMFELAVNRFLSLEKRLLKNPSVYQEYCTFMKDYLDLHHMELVFSPDEELQEFRLLTVTYGVSSAPFLALRTLLQLSEDEGREFPLAAEVLRTSTYVDDIVCGGDTLEIALDLRNELISLLSRGQFELRKWSSNDMRLLEGLPESHIGKKPISFDDTSCSSPLKILGLVWNAQLDCFSFEVTALDKSCTKRSMLSELARVFDPVGFLAPMTLFTKHLIQRLWLSGIDWDDSPPDSICKVWNQYKEQLLSLAQLEIPRCMFVSRYICCEERLSPNSWFYVPSAQNPADLASRGVLPALMLEQSHWFAGPEFLYNTDPIPDASCCFSECAEMFDEERTVTLACVNDDNFLENLLNDISDFSFIRRLIAWILRFAWNSKFPNDKREVSGMSKAHPVPTNVSDASVYIFKESGQFSKNILNMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVH4</accession>
    <name>A0ABM5JVH4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501941.1">
        <property type="nucleotide sequence ID" value="XM_050645984.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645984.1">
        <property type="protein sequence ID" value="XP_050501941.1"/>
        <property type="gene ID" value="LOC126881617"/>
    </dbReference>
    <dbReference type="GeneID" id="126881617"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="507" mass="59621" checksum="36A15D74A407E2A0" modified="2025-10-08" version="1">MKKVIQSKHFTKNCPEIRKVPDGPKQLLFNNWATRNDSSKVAALLHPDDYLEKPRRYLKDVPHKANRKADKETGVYRKCCMGTNTCYCREESIKPSLLRRPNKCLSLEAFEERFKEKLPIGRNSLHCFCKAGSASAENINLSDHEILQKYQEELECLNKNLQITDQRKDYEIFRDNEHLQYLKNIGQYKNSTLMSRLPHIPAYYFSNSHSKNSNLFRKNSRSAEDIDIYDEEHRSNYLPREKREVYPKQRSNYKSLDNYEETLSRQYPKDNDEGISSNGRQKEASLENYRNGSSSSGRTCLRSKCDRKFSVKQRTSVADNEDLQKINFTNNRFDPSDEEDAEEEEEEFYATRPKTVNAAMNTDQFKRFRNENYFETHDLEEHLVEDIPAHTCVHRYDLNERNMPIGVNVDIYGQSRCSICNKPMEDLQEKPYFSDKISPSRLKNLSKCYQLGLAPTTVIRSSSSIEIKVDRDNICPRFIGRCQRTQYKNTFALRQQKMATYRQENVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVL6</accession>
    <name>A0ABM5JVL6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501988.1">
        <property type="nucleotide sequence ID" value="XM_050646031.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646031.1">
        <property type="protein sequence ID" value="XP_050501988.1"/>
        <property type="gene ID" value="LOC126881652"/>
    </dbReference>
    <dbReference type="GeneID" id="126881652"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="304" mass="34495" checksum="D6446D205A5FA10F" modified="2025-10-08" version="1">MVSVFEDKQKVPGYEEIYLDGLVDNLGMNTNFITVSKWKALLVQVLFHSVAVNFTEQTLNHPKFQELLDSNKHFDVIVLEDVMYSALKGLSWYFKAPLILFSPFAPVTNFHITAGNSAPPSVIPNTLHGYSSPMTFWQRSFNSLAYMYDVLVSKFLSSPSQEAVMKKYFPGCPDLAAIDKNVSLFLINDHESINAPISHVPSMINILGFHLKDKNELPNNLQKYMDTAKEGVILFSFGSFVNPSKMDPQIKQAFLNSLGKLSQKVLWKTDEDNILGKPDNVILHKWLPQEDILGTQQMFRRDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JX25</accession>
    <name>A0ABM5JX25_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502491.1">
        <property type="nucleotide sequence ID" value="XM_050646534.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646534.1">
        <property type="protein sequence ID" value="XP_050502491.1"/>
        <property type="gene ID" value="LOC126881882"/>
    </dbReference>
    <dbReference type="GeneID" id="126881882"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="13206" checksum="34523896D7011086" modified="2025-10-08" version="1">MQKVLKRVTREKKPEDELDTRDSDRYVHQSTERDQHNENTLSRNYFKKAASPFHEFNEENSEEPPTKKTKESSTKSIQRFRAKWSDIEKQVLLQYFEKHIEKKNYPSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYK4</accession>
    <name>A0ABM5JYK4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503023.1">
        <property type="nucleotide sequence ID" value="XM_050647066.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647066.1">
        <property type="protein sequence ID" value="XP_050503023.1"/>
        <property type="gene ID" value="LOC126882242"/>
    </dbReference>
    <dbReference type="GeneID" id="126882242"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="332" mass="37970" checksum="3385CA6C9D7BE8E9" modified="2025-10-08" version="1">MPKLRKYDKNKLIEAVKDVQNGTESYRTAEKKYGIPKSTIEFKLKHPEHKDTLGPSPILTCEEENTLVRWIQETASKGFPKKANDLKSSVQKFLTENPRPNNFKDNRPGDGWLKGFLKRHPEVSKRTSEGVTAASACVSERDIKNWFKNIETYVKEKHLEEVLTDPSRIFNGDESGFQICPSTGKVFAMKGSKNVYNVEKSCSKENVTVMFTFSADGKICVPMVIYPYQRIPEKVAKGINPKWGVGRSDNGWMTAETFYQYIANVFYPHLIENNIKLPVILFVDGHKSHLSYQLSLLCNELQIEVIALYPNATRILQPCDVSIFRPLKEAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ72</accession>
    <name>A0ABM5JZ72_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503238.1">
        <property type="nucleotide sequence ID" value="XM_050647281.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647281.1">
        <property type="protein sequence ID" value="XP_050503238.1"/>
        <property type="gene ID" value="LOC114325934"/>
    </dbReference>
    <dbReference type="GeneID" id="114325934"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="625" mass="72902" checksum="CDCE554FBB189E8F" modified="2025-10-08" version="1">MVMVKYIKCHKIKRKRSVIKMNQNQMEVNHQISEETFKIEIKYNHLNDALLDEFKCEIQEESNWESTHDKHGSLDLQKFPIKTEIDQHGNNLNRFKENQKTEKDYLQENKMEIIETVTEHSSNEENYMNLHAEEKTLNENVKVVTAEKPHKCEICFKQFSKAGNLKIHLRVHTGEKPHKCEICFKQFSVTGTLKTHLRVHTGEKPHKCEICFKQFIAAGNLKDHLRTHTGEKPHKCEICFKQFITAGQLKQHLLMHTGEKPHKCEICSKQFSVAGTLRLHLRVHTGEKPHMCEICFKQFNKASHLKIHLRVHTGEKPHECKICFKQFSVAGTLKTHLRVHTGEKPHKCKICFKQFITAGNLKKHLRVHTGEKPHKCEICFKQFITAGQLKGHLLMHTGEKPHKCEICSKQFSLAGTLKTHLRVHTGEKPHKCEICSKQFSLAGTLKTHLRVHTGEKPHKCEICFKQFSLASHLKTHLRVHTGENPHKCDICFKRFNQAGHLKHHLRVHTGEKPHKCEICLKQFIESGTLKIHLRLHTGEKPYQCDFCLNRFTQKNNLTDHMRVHTGEKPHKCETCFKKFITTNQLKAHLRVHTGEKPHKCEVCSKQFSEASNLKRHLRTHTREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZG1</accession>
    <name>A0ABM5JZG1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503331.1">
        <property type="nucleotide sequence ID" value="XM_050647374.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647374.1">
        <property type="protein sequence ID" value="XP_050503331.1"/>
        <property type="gene ID" value="LOC126882423"/>
    </dbReference>
    <dbReference type="GeneID" id="126882423"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="302" mass="35605" checksum="B5D25AA67BA59B03" modified="2025-10-08" version="1">MSLNNRISERLSQCYRGKHQMQNTFNEQKQNTISDDEKILLLQYASKQQLNNYYECQDTVNNSFHYKWAEVSKIFKEKGYKREPEELAKYFLSMKHTAMSRFKGYFFNKNKRPTIPGDYVLANLFPEYFESLGFDMSELMTDSKKYSKQILEYLVPIEDQEHPTLLKDVASLCNLNDVESQQNLKRPHSEDVEGPSNKITKEVHEDEDVLYERVLDITRGKNRKNNEDEGKTNSEATPLLSLIKENNSLTDDRNALEAKLLAAEKQLREKDDELERKNLEISLLKERHANELEIEKIEHLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0J4</accession>
    <name>A0ABM5K0J4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503704.1">
        <property type="nucleotide sequence ID" value="XM_050647747.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647747.1">
        <property type="protein sequence ID" value="XP_050503704.1"/>
        <property type="gene ID" value="LOC126882753"/>
    </dbReference>
    <dbReference type="GeneID" id="126882753"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="55213" checksum="81FD4A9838A44BF5" modified="2025-10-08" version="1">MGASLDELASILDTSEKKILKREFSNLDDDTFNLLTCKGVFCYDYIDSVEKLDETSLPNIRHFYNKLNNEYISEEKYAHAQNVWNKFNCKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYKLDPAWYYTMPGYTWDCMLRYTKCKLELLKDVDMILFMEKAIRGGISVCSNRYSEANNKYMSTYDPTQPSKYIMYLDVNNLYGWAMSEALPIGGFKWIEDGTKFGVASKSTNLPEGHIDIMSIPNDAKEGYFFQVDLEYPRELHDKHKDFPFAAEHRIPPGSKLPKLIPTLYHKTKYIIHYRNLKQALENGLILTKIHRVLKFKQSAWLRPYIELNTNLRTAATSSFEKNLFKLMNNAVFGKTMENIRRHRIVKLCKKWHGRYGAKNLIASSRFHSRTIFHENLVAIELKKSEVCFNKPLYIGAAILDISKLCMYDFHYNFMLPTMGEENCSLLYMDTDSFIYELQCSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1C1</accession>
    <name>A0ABM5K1C1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503988.1">
        <property type="nucleotide sequence ID" value="XM_050648031.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648031.1">
        <property type="protein sequence ID" value="XP_050503988.1"/>
        <property type="gene ID" value="LOC126882951"/>
    </dbReference>
    <dbReference type="GeneID" id="126882951"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045470424" evidence="1">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="197" mass="22067" checksum="E4D36839236AAA4B" modified="2025-10-08" version="1">MLVIKKMMILLTLWLSVNLAMCRKNLGDEEEEILHPVLRKFQKRQICQELCSSGLGGNSCGKDCVEIFQQKIYMQLSTSTDLTGNHVTKNVPRSDMCPVLCKYNLGKPLCVCSQVQNVVSSKAINFLEICSKFCIKHNYRISGCQKCSIYQQATLPRKSASALPDPNEIDWNAWCTVKCKENDGGAACDCDRSPMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4R8</accession>
    <name>A0ABM5K4R8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505182.1">
        <property type="nucleotide sequence ID" value="XM_050649225.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649225.1">
        <property type="protein sequence ID" value="XP_050505182.1"/>
        <property type="gene ID" value="LOC126883578"/>
    </dbReference>
    <dbReference type="GeneID" id="126883578"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="83692" checksum="BA67B462F3E602CD" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQSTVATAKVRLPEITMQTFCGSFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFATHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQTPQNSQGASRVVAPISTQHSFNNRSQNEASTSSSRPPLDMQNSPDSQAATSLSALSVTTDVLLATALLQISTISENTSLSNEMLNLEFFPYNVKDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKIDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFVQSEPEEHKLDKLLQQFFEIEEVPLISKLTPDEELAEQIFSKTTLVLPSGRFQTQGYNNLGNMGLKRYKDRDRHANFKYARLMIADLLGSPSVTHGASYVVLTNDLSGYFSSSGGRFAFWGGDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4S1</accession>
    <name>A0ABM5K4S1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505184.1">
        <property type="nucleotide sequence ID" value="XM_050649227.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649227.1">
        <property type="protein sequence ID" value="XP_050505184.1"/>
        <property type="gene ID" value="LOC126883579"/>
    </dbReference>
    <dbReference type="GeneID" id="126883579"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="212" mass="24804" checksum="B30F0EBA7548AF16" modified="2025-10-08" version="1">MSSSKIRYTRQYIECPLAGVPADFKGNVLPLKAHVLQYYLWTRYNLKSPNSGKEPTVFEISNILSDKILSVWQKASILTITRKRVLQLIKTHHDKYLKLLRYPEVKKNDSYSICVQEFQTENTRLFDISACKCEILEQCSCDKGKKVPKNEREFLLDQRGPRKMINGNIDLKETLKLTNKARRVEKEMQRKQLKQSIQHESCNNIKKAKARN</sequence>
</entry>
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        <location>
            <begin position="1910"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1924"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2094"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2105"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2183"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2197"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2275"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2457"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2640"/>
            <end position="2650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2651"/>
            <end position="2665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2729"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2743"/>
            <end position="2757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2820"/>
            <end position="2833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2834"/>
            <end position="2848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2911"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2925"/>
            <end position="2936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="3004"/>
            <end position="3014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="3015"/>
            <end position="3027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="3472"/>
            <end position="3484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3484" mass="376139" checksum="D40B88BB31AD39D8" modified="2025-10-08" version="1">MRTFVLNFEKSWLYIVLYYYFGCVFVKTHPVCPPRDGQESIYHPHEDCTKFWQCSNGVPYLFNCPPSLYFNTKLNVCDWPYNVQCPPPTTQPTTTLTNKPPIVTTKQPPPLTTTTQKTPWSSESTGTTDTSEITSILPSSQFTTIETSSIGTISDNTKVSISTSKATTPKITSTSTAAPNTYDTTDKSTDISSKPTISTSSKLSTLSTYVTTTSNIPTISSIKTSTSRSTLEPLTFQTTSLLTSDGSNSSSELPSTAEASTVTIPIVSSEYTSTSSPNTPKSSTLSSTQSSPTDTTRISTKSTTATSSETNTSESDSSVTTTSHTTDDLDDTDTTQDRLTSSDTSKITSTTELVISSRIPQSTTSITTMLEDDITTDEFTETTDSINDTSHTTDSENIPNSSKITTPEEFIEETSTTETKEDASMTSTSTTGNDNIPSSSKTTITEEFTEEKSTAESTYSTNNQGNNTETKEDGTIISTSTTDNENIPNSSKTTITEEFREETTITEASYSTNNYDNTTETKEDESITSTTDGSTSTSIKHITSTSTETIGSESSIDISSSSIETEEDTEETITTESTYSTNHEENTTETKDESKIFTSTTDNENIPNSSQTTITEEFTEITTTTYSINDEDITTEIKEDESMTTTSTTDGPTSTSTKHVTSASTETIGSESSVDISSSSVETEEDTVETTTKESMYSTNHEENTIETKEDETIISTSTTDNENIPNSSKSTITEEFTENITITETSYSTNNEDNTTETKEGESMASTSRTDGSTSTSTKHITSTSTETNGSESSVDISSSSIETDGNTVETTTTESTYSTNHNENTTETKEDKTIISTSTTDNENIPNSSKSTVTEEFTENITITEASFSTKNEDNNTETKEDESMTSTSRTDGSASTSTKHITSTSSNVETEEYTEETITDNTSTTETSDNTVNSSSIIVDTTTFETITEKSNDMITSSITDSIASITEFYTRDSSTESDPNRTVITDETSSSSSTVVTSRPISSSRAISSSTISTTRANENLDYICQNNPGQYFLTAHPANCALYIACSFGKANIYRCSNGLWFSSGHLRCVESHLSDCKRMDTTSIISSAPFITTIIDNNENTQIICSDVNKITYNCHPEYCTKFIVCVHGVEYVMDCPSGLWFDQNLEKCVYPHNTKCFAAKNRKLLRTMSIFANIKGYIHSSLIDNFRFEPSFCLYSRTMVPVLILFFFCVSVHSGLANVECPKVDGPDSVYYPHEDCAKFYQCSNGVPYVHNCSSGLHFNSKLNVCDYPLEAGCEEITIDYPSSPPSDDNGDKNFCLLKSFLCPPIDGSTSVYFPQQNCTKFCQCSNGVPYEHTCRDGLHFNPILNVCDWPENAGCRGSETHTCPTITTPFTPTDSTTPNSNSCQKEGIVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHDCPAGLHFNPKLNVCDWPQNAGCGGSDTVTTEQTVTPTQDSGNNTNPTPAPNSCQKEGVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHDCPAGLHFNPKLNVCDWPQNAGCGASDPVTTEQTITPTEDSGNNTNPTPAPNSCQKESVVCPAVDGPDSVYFPLRDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTPTQDSGNNTHSTPAPNSCQKEGVVCPAVDGPDSVYYPLSNCTKFCQCSNGVPYEHDCPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTTTQDSGNNTNPTPAPNSCQKEGVVCPAVDGPDSVYLPLRDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTPTQDSGNNTNSTPAPNSCQKEGVVCPAVDGPDSVYFPLRDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTPTQDSGNNTNSTPAPNSCQKEGVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHDCPAGLHFNPKFNVCDWPQNAGCGGSDPVTTEHTVTPTQDSGNNTNPTLAPNSCQKEGVVCPAIDGPDSVYFPLSDCTKFCQCSNGVPYEHDCPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTTTQDSGNNTNPTPAPSSCQKEGVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTPTQDSGNNTNPTPAPNSCQKEGVVCPAVDGPDSVYFPLRDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTITPTQDSGNNTNSTPAPNSCQKEGVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHDCPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEHTVTPTQDSGNNTNPTPAPNSCQKEGVVCPAVDGPDSVYFPLRDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTITPTQDSGNNTNSTPAPNSCQKEGVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHDCPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEHTVTPTQDSGNNTNPTPAPNSCQKESVVCPAVDGPASVYFPLSDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTTTQDSGNNTNPTPAPSSCQKEGVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHACPAGLHFNRKLNVCDWPQNAGCGGSDPVTTEQTVTPTQDSGNNTNPTPAPNSCQKDSVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCAGSDPVTTEQTVTPTQDSGNNTNPTPAPSSCQQEGVVCSAVDGPDSVYFPLSDCTKFCQCSNGVPYEHACPAGLHFNPKLNVCDWPQNAGCGGSDPVTTEQTVTPTQDSGHNTNPTPAPNSCQKENVVCPAVDGPDSVYFPLSDCTKFCQCSNGVPYEHNCPAGLHFNPKLNVCDWPQNARCGGSDPVTTEQTVTQTQDSGNNTNPTPAPNSCQKEGVVCPAVDGPDSVYFTLSDCTKFCQYHFTRYAEAIPIKDLSAETVARVFVNEVVLRHGAPERLLTDQGTNFVSELMKEVCRLLGIKKIQTTAYRPQVNGRVERLHRTFIGMVKHYVNSKARDWDEHIGLALMAYRSAKHNATGFTPNWLIFGREVHIPFDCDVGPRIDDRGELSYPAELRRRLDEAYILAAEQARKLEQTNAERMDRGRHERNLKEGDYVYIQNPIVPSGVSKKFFKPWSGPYKIIEKRGAVNYVVDKGDGKTQTYHIDRLKYYKAWEDPDVSEEQIGNQAKPTLSLPRIIEDGVEERPRMTDDEGSDEEGEIVWGYAREPEVDDDDLGGTADIGDVPDESRMITPRTRRPPQRYTPTSDGVNESEFWTDDSGLSEELQDLQQLTDTNSEEEQMVTAEVGESSGDEEILDVINEATVEEPRLSRGGRPQRERRKPLRYRVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K552</accession>
    <name>A0ABM5K552_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505318.1">
        <property type="nucleotide sequence ID" value="XM_050649361.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649361.1">
        <property type="protein sequence ID" value="XP_050505318.1"/>
        <property type="gene ID" value="LOC126883700"/>
    </dbReference>
    <dbReference type="GeneID" id="126883700"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27713" checksum="D2622ABBEBE818B6" modified="2025-10-08" version="1">MTDANISANTSASVDRISVKTPPFWPNDPEIWFLQIENQFTLANITSDATKFNYIVANLDTAYILEVRDIIVSPPATERYAKLKSELIKRRSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPDNIVRSLFLGRLPASTQAILATQAKASLDVVAELADTISEAIASRAQISEASNTLESTIDKMTAELADMKIQLASLTQAQAQTNTYRRNRSNSRRRPYPRDSSYSREHNSDILCWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5H7</accession>
    <name>A0ABM5K5H7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505447.1">
        <property type="nucleotide sequence ID" value="XM_050649490.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649490.1">
        <property type="protein sequence ID" value="XP_050505447.1"/>
        <property type="gene ID" value="LOC126883820"/>
    </dbReference>
    <dbReference type="GeneID" id="126883820"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50241" checksum="BD49CAA966ED1E05" modified="2025-10-08" version="1">MPKGHTRYLSHDIQNQIINCMSLKLKGKLLENINKARFFSLIVDTTQDLDKKDQLSFVIRYTNFFEELRQDEDGNFEEYKKLSIEESFLGFFHVKDATALGLSTQVVDCLQNLGVQKRLQEIEKLAVYVHCNAHNLNLAINDAVKEVRAVDSYFTTLQSLYVFFGLSIKRWDILSSLTGESEVTLKKLNPTRWASRHDSILAVKVRYLDIMKALTKIILESNKQEEVSEAKALAKSLDNFQFVMLTVVLSKIFTQLNITSKFLQGKETDLEKAARVLERSQTELKKMRDDYEAYKDEATLIARKWNVQPMFSQSRQRKVKRHFDELAEDFRFSCGEEAFRVQVFYAVLDIVNRQIEDRFSSVRDVVQLFSVLFPTVLVKLTEKEIFEKAGELQRVYEKDIGLSLPLELISLQSGFKCELSKLKTVYDSFTFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6C1</accession>
    <name>A0ABM5K6C1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505735.1">
        <property type="nucleotide sequence ID" value="XM_050649778.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649778.1">
        <property type="protein sequence ID" value="XP_050505735.1"/>
        <property type="gene ID" value="LOC126883999"/>
    </dbReference>
    <dbReference type="GeneID" id="126883999"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="126" mass="14590" checksum="A6FE42A939AB337D" modified="2025-10-08" version="1">MFSNKTRNRLCKNAVPRLFPSIEESPNQHSNVDQDDENSFDPVNEEDEEQRQELATVLLGGEDDSEVVLQKNQQTQTLESVSTYSPRKNKLRKTIKELQNKNFRLKKKLQKLQGSGKPDYLKNITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAB8</accession>
    <name>A0ABM5KAB8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507134.1">
        <property type="nucleotide sequence ID" value="XM_050651177.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651177.1">
        <property type="protein sequence ID" value="XP_050507134.1"/>
        <property type="gene ID" value="LOC126884865"/>
    </dbReference>
    <dbReference type="GeneID" id="126884865"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17265" checksum="73E1CAE71BB5E66C" modified="2025-10-08" version="1">MAKAFGDSKMAEKFESVPLSHQTIQRRIVAMGEQVEKSMLSLVKKSSYFSLCLDESTDQTDVSQLLIFVRPTFDDFTSKEELFDICPLYGTTKGKDIYEAVKKTVDRIGGFGKCSAIATDVAPSMTGKKIGLVGLLRENGVTCPIIQCIIHQGALCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD39</accession>
    <name>A0ABM5KD39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508107.1">
        <property type="nucleotide sequence ID" value="XM_050652150.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652150.1">
        <property type="protein sequence ID" value="XP_050508107.1"/>
        <property type="gene ID" value="LOC126885563"/>
    </dbReference>
    <dbReference type="GeneID" id="126885563"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="79277" checksum="2AFA41CCCB934FF9" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQSTVATAKVRLPEITMQTFCGSFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFATHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQTPQNSQGASRVVAPISTQHSFNNRSQNEASTSSSRPPLDMQNSPDSQAATSLSALSVKTDVLLATALLQISTISENTSLSNEMLNLEFFPYNVKDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKIDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFVQSEPEENQLDKLLQQFFAIEEVPLVSKLTPDEELAEQIFSKTTLVLPSGRFQVKGNNSCLSLSTVRINHDFVYEFVPVHLCECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEL0</accession>
    <name>A0ABM5KEL0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508598.1">
        <property type="nucleotide sequence ID" value="XM_050652641.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652641.1">
        <property type="protein sequence ID" value="XP_050508598.1"/>
        <property type="gene ID" value="LOC126885869"/>
    </dbReference>
    <dbReference type="GeneID" id="126885869"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1445"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1528"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1556"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1584"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1613"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1641"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1669"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1697"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1726"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1754"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1782"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1099"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1305"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1324"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1380"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1399"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1819" mass="207276" checksum="AFE6614D121EC2A5" modified="2025-10-08" version="1">MELEYSDVSAEVKGSLTPGKLKLTEQNIIFKNSTSGKVQQIPSSDFDVVNFQTFADTWSICLFLKNGTLHRFVGFKDSEKEKIAKFFSNAYKIEMLEKDLSTVKNGSVLSFDVGSNSSFEIPLNHISQCTGGKNGIAMEFHQNDDAPVSLMEMKLKDPVEVFQQQVVDKASVINISVDAIAIFRKINCLTPRGRYDIKIFNSFFQLHGKTFHYTIPLTTVLRLFLLPHKDSRQMFFVVSLDPIKQGQTGFHFLVFLFNRDETSIELPYTEEELKEKFEGKLQKELNGPTFEVMSNIMKTITNKKLTGPADFIGHSGTPAISCSFKAKAGLLYPLERGFIYVHKPTIHITFEDMASVNFARAGGSTRAFDFKIDLKSGTVHTFGSIKKEEYGKLFDFITKKKLNIKDEFGESFEEAAPNAYLARVKAKGQEKDDDDDEKDKERYEQEMKEFKASLGDTSKENKKSSANTDKKASDVDPVEVFQQQVVDKASVINIPVDAIAIFKKINCLTPRGRYDIKIFNSFFQLHGKTFRYTIPITAVHRLFLLPHSHLLPDSRQMLFVVSLDPIKQGQTSYYFLPFLFNRDETSIELPYTEEELKEKFEGKLQKVLSGPTFEVMGNIMKTITNKKLTGPADFIGYSGTPAISCSFKAEAGLLYPLERGFIYVHKPPTYIEFEDIVSVNFARGGGSTRSFDFKIELNSGIVHTFGSIEKEEYGKLFDFIIKKKLNIKGQERDDDGDDEKDKERYEQKMKEFKASGGDTSKENKKSPAKADMKPSDVDVVEVLQQQVVDKASVINISVDAIAIFRKINCFTPRGRYDIKIFNSFFQLHGKTFRYTIPITTVLRLFLLPRSHLLPDSRHMFFIVSLDPIKQGQTGFHFLVFLFNRDETSIELPYTEEELKEKFEGKLQKELNGPTFEVMSNIMKTITNKKLTGPADFIGYSGTPAIICSFKAEAGLLYPLERGFIYVHKSPIYIGFEEIASVKFARGGGSTRSFDFEIEVKPCTVHTFGSIEKEEYGKLFDFITKKKLNIKDEFGDSVEEAAPDAYLARVKAKGQERDDDDNEKDKERCEQEMNVGGGEKASGDDTLKENKTSPAKKDKKPVANKRDSSPNEVEEAAPDAYLARVKAEGQERDDDDNEKDKERCEQEMKVGGGEKASGDDTSKENKTSPAKKDKKPVANKRDSSPNEVEEAAPDAYLARVKAECQERDDDDNEKDKERCEQEMNVGGGEKASGDDTSKENKTSPAKKDKKPVANKRDSSPNEVEEAAPDAYLARVKAEGQERDDDDNEKDKERCEQEMKVGGGEKASGDDTSKENKTSPAKKDKKPVANKRDSSPNEVEEAAPDAYLARVKAEGQERDDDDNEKDKERCEQEMKVGGGEKASGDDTSKENKTSPAKKDKKPVANKRDSSPNEGFPQEENTLEIMEAIPVNPSKKQRISQPAEETPYMCVFCFERFSHTDDLEQHARTHSVENPKKWQTCSKRFFGADLKNHITPHTGDECNRCENCFKGVCRAFQLNRLITSHTEEQLKKCQICFEQFSQAGSLKKHMRSHTGERRYKCEVCFKHFDHASYLKNHTRTHTEEKPFQCQMCFKQFSQASGLKYHIMRSHNEDKRYNCEICCKSVCRAFQLKRLIRMHTEENLKECQICFKSFSEASSLKQHISSHTREKRYKCEVCLKHFGQASDLKQHITTHTEENSYKCQMCCIEFSQARSLEEHNIRSHTKENCYKCQMCSIEFSETASLEQHNMTHTDEQRYKCKICFKHFDRASRLKRHKITHIEGKPYECRMCLKQFSRADSLQDHICVLCVNRVKYSKKTVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFB4</accession>
    <name>A0ABM5KFB4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508875.1">
        <property type="nucleotide sequence ID" value="XM_050652918.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652918.1">
        <property type="protein sequence ID" value="XP_050508875.1"/>
        <property type="gene ID" value="LOC126886074"/>
    </dbReference>
    <dbReference type="GeneID" id="126886074"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="117"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="222" mass="24880" checksum="CEC9409952943A55" modified="2025-10-08" version="1">MQPVSIDSECITRFSHGLVNIVDPENLGLEKACKILDSNPNFQASRKPEPAIKWWREGKLIESTETRSGFEKVRSNQLIVRGLQRSDQHAAFTCQASNNNISQPVSATTSIEIHFRPLTVEILISNNPFSADRKYDIPCQSFGSRPPAKITWIMDGKELLPPKYNATYSDSEDGNSTTSILSFVPTRLDNGRSLTCRASNHLVQNGVEEHTVKLNVFCKLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFV3</accession>
    <name>A0ABM5KFV3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509081.1">
        <property type="nucleotide sequence ID" value="XM_050653124.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653124.1">
        <property type="protein sequence ID" value="XP_050509081.1"/>
        <property type="gene ID" value="LOC114324592"/>
    </dbReference>
    <dbReference type="GeneID" id="114324592"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF17">
        <property type="entry name" value="LD24139P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="455" mass="51374" checksum="C7B0579392DB7529" modified="2025-10-08" version="1">MRNFSLILSQKLNLVYDDASLEADFEEIRYYHADMEEEMKKSISEVLDVSQRVPHFITFSEAATNENARDEIEIAEGHITPVTKEDEKTFNDSSITVQEVKEPETETKLEIEVKAHGLNRVAETKRLQFPLVNELIKNGKRFHKDPLRVQLFRYRFPNTPLLPELVLTLWGTWLDAALYYTEYFEDFKSFVLELTDSASKSIKDCQDVLGETELQNNLAQNDSIEETNNGNDQNESWTKVFNCGTETLLQIIDTANDIKKVDIIPGISLVSNVGNARTAKDLVYPYNYTNLPTDPSERKKELTDLLIKAIQRLLSTKILQLRLPNYTTTNVSQSLEEARAKMKRMSYPSWMLGVGTMALTLTPLLLGGLTLLSVKALVVAKIALFIVLVVQFFSSGMQIPTPTAYIPTYFSYGHGHSSLPYPYIPTTNQGGGGVNSLGGWNSNGGWSQDKSYNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KH38</accession>
    <name>A0ABM5KH38_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050509458.1">
        <property type="nucleotide sequence ID" value="XM_050653501.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653501.1">
        <property type="protein sequence ID" value="XP_050509458.1"/>
        <property type="gene ID" value="LOC114332656"/>
    </dbReference>
    <dbReference type="GeneID" id="114332656"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="64"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="395" mass="43187" checksum="A5ED55C57F5EF8DF" modified="2025-10-08" version="1">MLPNCVRTVCTKTVLPKKTLGAFSKNFATEASFETKPYRLHKLDESPATSVSLNKEDAINYYTQMHTIRRMETAAGNLYKDKIIRGFCHLYSGQEAVAVGIKAALRPYDGVITAYRAHGWTYLMGVPPVGVLSELCGRQKGCAKGKGGSMHMYTENFYGGNGIVGAQVPLGVGIALAAQYKGTDGVCIALYGDGAANQGQVFEVYNMAKLWNIPCIFVCENNGYGMGTSAERASASTTYYSRGDYVPGIWVDGMDVLAVRECFRYAVNYAGSGKGPLVIEAATYRYSGHSMSDPGTSYRTRDEIQEVRQTRDPITSFKEKIISSNLVTPDEIKKIDGEIRTQVDEATKQAKSDAELGLDELPADIYAVNLEGQIRNIDPWTALTHKRIGPAVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHB6</accession>
    <name>A0ABM5KHB6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509585.1">
        <property type="nucleotide sequence ID" value="XM_050653628.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653628.1">
        <property type="protein sequence ID" value="XP_050509585.1"/>
        <property type="gene ID" value="LOC126886635"/>
    </dbReference>
    <dbReference type="GeneID" id="126886635"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="591" mass="67141" checksum="93D92698EF3EDA54" modified="2025-10-08" version="1">MPRNYKRVTEKASWREEELQGALRAIQNGMSLRKAAIKFSIPKSTLHERLKNGTAPSGPSLGRKPVFSVEAENALAVQIKKLAKVFYGITPQEVRRCAFGFAQSNNIRVPFNQERKMAGKDWERGFISRHNITLRKPEATSINRITAFSRNEVTIFFNNLSRLMEKYAFSPNKIYNCDETGVTTVQRPPKIYAEKGQKRVGFVTSWERGKTTTAVCAVNATGTYIPPMFIFARQRMASHLQRNGPPGALYTCSKNGWITEDIFLTWLQHFQAFVKASKEDPVLLIMDNHSTHCTLQAYNFCRDNGIAVLTIPPHSSHRLQPLYVSFYFPLKTAFNSECSKYLTSHPGEKITPSEIAELFNLAFSRVATPEKAIKGFKETGIFPYNPDVFTDEDFAPAETFQSTVSDALQEPTQAEKLLKTNETTPEKNSSVNETELKNVSFAEIIPLPSCSHENVVKRQNKANKQHSIVFTSTPLKEELEKKEEKKNKKTTIKSDKAKRNVFMTQEGSTLRQKSKRTKIALNYKICEEGESEIEDDDDVRDKNITEDICILCGEFGKNSELWLRCVYCGHWAHKACSNSPKDKKFICDFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI01</accession>
    <name>A0ABM5KI01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050509820.1">
        <property type="nucleotide sequence ID" value="XM_050653863.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653863.1">
        <property type="protein sequence ID" value="XP_050509820.1"/>
        <property type="gene ID" value="LOC126886798"/>
    </dbReference>
    <dbReference type="GeneID" id="126886798"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="209" mass="23640" checksum="514D829FB8411A29" modified="2025-10-08" version="1">MAHTYKLTYFDLTARAEPIRMLFNYGEIPFEDKRIQFGDWPKIKSTTPLGQLPVLEIDGKAIPQTIAICRHVASLVKLDGKDAKENLALDVAVETLLDLQKLGFESMFGSDAKKKEALENLKKSIPTYFGQLEDYAKKHNGYIAFDRLSWADILFVCVYELLVNVAGKEAVSAYPNLQRVKKNVLAAKGINKWIKNRPTSQGYDLKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKD6</accession>
    <name>A0ABM5KKD6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510667.1">
        <property type="nucleotide sequence ID" value="XM_050654710.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654710.1">
        <property type="protein sequence ID" value="XP_050510667.1"/>
        <property type="gene ID" value="LOC126887266"/>
    </dbReference>
    <dbReference type="GeneID" id="126887266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF33">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="287" mass="32206" checksum="4AF8FC1D7CCE3B27" modified="2025-10-08" version="1">MHCQSRKVNTSSRFLHSMERVRNRLKNRQVCCAGHQKLIQAETDKWTNILKCIVDVILHCARNNLALRGGSDLIGDSNCGVFLSTLELISHYNPQLAKHIETVKHGKNVTSYFSPLIQNKVIDLLGSNVRSEILRKVKRAKYFSIMFDCTPDTAHLEQMSQVIRYVTIEDGKCSVEESFVDFVITHQKTGRGISQEILEKLKTDDLDIQNCRGQGFDNGSNMAGKYEGVQAHISQLNDLATFVPRAAHSLNLVGVRAAEVSVMMKTFFGNPCVRKCHPILVFCLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLA7</accession>
    <name>A0ABM5KLA7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510985.1">
        <property type="nucleotide sequence ID" value="XM_050655028.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655028.1">
        <property type="protein sequence ID" value="XP_050510985.1"/>
        <property type="gene ID" value="LOC126887476"/>
    </dbReference>
    <dbReference type="GeneID" id="126887476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF16">
        <property type="entry name" value="PHOSRESTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="189"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="380" mass="42478" checksum="2B17F3705943DF70" modified="2025-10-08" version="1">MVFNFRVFKKQSPNGKLTMYLGKRDFVDHISGVEPIDGVVVVDNEYKDRKIFGQIICSFRYGREADEVMGLNFQKDLYLASEQIYPPPEKSLNTKMQDRLLNKLGENCYPFTFTLPPSAPASVTLQPGTEDEGQPCGVHYYVKIFVGENETDRTHKRGTVTMAIRKIQYAPSKQGRQPCTVVRKDFMMSPGELELEVTLDKQLYHHGDKIAVNICIRNNSNKVVKKIKAMVQQGVDVVLFQNGQYRTSVASIETQEGCPIQPGSSLQKVVYLLPLLSSNKDRRGIALDGQLKKQDSNLASTTLLASPDQRDAFGIIVSYAVKIKLYLGALGGELAAELPFVLMHPKPNARGKVIHADSQADVETFKHDTIDQDADDDKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLU7</accession>
    <name>A0ABM5KLU7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511167.1">
        <property type="nucleotide sequence ID" value="XM_050655210.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655210.1">
        <property type="protein sequence ID" value="XP_050511167.1"/>
        <property type="gene ID" value="LOC126887616"/>
    </dbReference>
    <dbReference type="GeneID" id="126887616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="316" mass="34186" checksum="B0DD300B79DDD117" modified="2025-10-08" version="1">MRQESVVLEEWDGVSVAAGSGSSTRPRWRRSAGQQRSKLEAVSGTANGPRWRRSAGQRRSKLDGNQRESNGARWGRSAEQQRSKVEAVSGTPTKVEAFSGTATVQGGGSQQDSNGPRWRRSAGQQRFKGGGGQRDSNGPRWRRSAGQQRSKVEAVSGTATVQGGGDQRDSNGPRWKRSAGQQWSKVESISGTATVQGRGGQRDSNGPRWRRSAGQQRSKVESISGTATVQGRGGQRDSNGPRWRRSAGQQQSKVEAVSGTATVQVEVKRSPEQPITIRFNFNTASLASGYADDSLNRPTRGTKLCVGRFTCGKRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNU6</accession>
    <name>A0ABM5KNU6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511864.1">
        <property type="nucleotide sequence ID" value="XM_050655907.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512525.1">
        <property type="nucleotide sequence ID" value="XM_050656568.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655907.1">
        <property type="protein sequence ID" value="XP_050511864.1"/>
        <property type="gene ID" value="LOC114328727"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656568.1">
        <property type="protein sequence ID" value="XP_050512525.1"/>
        <property type="gene ID" value="LOC126888372"/>
    </dbReference>
    <dbReference type="GeneID" id="114328727"/>
    <dbReference type="GeneID" id="126888372"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028510" evidence="2">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27915" checksum="129124D6690D14CC" modified="2025-10-08" version="1">MTFKLAVLTVICLGGLAAQQIPVKRQVNHATTAVEKEDHVPAETGFINPAAAVHQGSKFFQDIYVAMDKPDELEFGHVRETPNDWEQRYEKLNLETLKHQGKVRWGDKHGGYGEHYWDYNHAGHGHDGDGDESQQNEEYAEYEEESKNEPIVSPLPQNQRGKREPALLDDVEFINDKARSLSFDRSAQRHGGNYRAVNDNRGKREQSRGKSRQAPKNFGESLVFDADEGIVLDEETGLRYQLSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPX5</accession>
    <name>A0ABM5KPX5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512243.1">
        <property type="nucleotide sequence ID" value="XM_050656286.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656286.1">
        <property type="protein sequence ID" value="XP_050512243.1"/>
        <property type="gene ID" value="LOC126888226"/>
    </dbReference>
    <dbReference type="GeneID" id="126888226"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1352" mass="153068" checksum="A75FB2ED0A6C232D" modified="2025-10-08" version="1">MLLSLLKHNVTKSIINRNSINVICAFKKYSSKESVSLGNIVKEITEAERPEYVPIKYYHDDIPKSSLHHLKWMLQKELLNQDIFLLGPPGPRRRHLAMQFLELTNREHEYVALSRDTTESDLKQRREIVQGTANYFDQSAVKAAKEGRILILDGIEKAERNVLPVLNNLLENREMHLEDGRLLIPAARYDKLLKEHGEEELEKWKLVRVDSNFRVIALGLPVPKYRGNPLDPPLRSRFQARYVHNNSYQEYLSVMRNLAPNVAPEKLEQIVASAFALLTKESATLGLPDFPLDNLLLGAIIMEQNPSLSPYEIIYRLYPYKVFLKDGVQHVENLLTELGLPTSKQTESVNVSTKLPTSSSTSVNSYIETKYQNALLESIVQSLKVADVCIVGTKGCGKSMIVNKVAEIFGQDVESIVLYQDMTSRDLIQQRTTLDNGDTIWKLSPLIEAALEGKIAVLDGINRIHPSTLTVLHRLVQDRELQLYDGKRLISKNRYEVLQKKFNLTEEQLTENGVFPIHPDFRIVAIGEPPNLQSPTGNWMSPEMLSIFLFNEMRTLSKEEEIHVITTKFGPPSAPLQKIISLAHILRDNTDPALKNLSGHLSTRKILKIASRLNKYPTDDVYNLMEETFMIKFLPSLTRQALDKTMEKIGITFIPQDENAKIKCEIKNGMLTIGATTAPLYQASNLTKIPDTLFYDVPQHLSLMERLLQDFQLGYNLLLVGNQGVGKNKIVDRFLELLKRPREYIQLHRDTTVQTLTIQPTIKNGILVHEDSPLVKAIKYGHVLVIDEADKAPTHVTCILKTLVESGEMILSDGRRIVPNTKTLKGSNTENIVVTHPDFRMIVLANRPGFPFLGNDFFGSLGDLFSSHSVDNPSRESEIELLKQYGPDVDVNTIKQLVGIFGELRNMADQGLINYPYSTREVVNIVKHLQKYPNADLEDVLFNVFDFDRDSPDMLETVGEVLHKHGFSKNVVSTEYIAAKRAKENVTVNRYSGLDTKEPKHGEEDPDNAPHVGGNRWAGGTGGRDTAGLGGKGGPYRLDKGHKIFQLSDQEKNDVPEHVKRAAREMGRNAFKQKLKEIGMDEYDHSIYSQFSVAVERPVQALRVILNNLQAKNQERQWYRHQTTGELDDVKLIDGILGEKTIFRRRSEQKPELGTPQIKPKLFRVVVDVSGSMYRFNSYDGRLDKELEAVVLVMEAFEGFDDKIKYDIIGHSGEEYNIRFVDIDSPPKNNNDRLKVLRTMYAHSQYCMQGDHTLETTQWAVSNIDEEAYDEAIVIVLSDANLQRYGIPAEDLAKAMTEKPNINACAVFIGSLGDQAERLRRSLPAGKAFICNDTKELPHILKQIFSSSVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ30</accession>
    <name>A0ABM5KQ30_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512298.1">
        <property type="nucleotide sequence ID" value="XM_050656341.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656341.1">
        <property type="protein sequence ID" value="XP_050512298.1"/>
        <property type="gene ID" value="LOC126888247"/>
    </dbReference>
    <dbReference type="GeneID" id="126888247"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045232717" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="117" mass="12826" checksum="2B88E2F57CA74A61" modified="2025-10-08" version="1">MSVKMTIASALLVVLICQSISVSNAKNLVDCPDTSLARNEVYDKEISTSVVGSSIRVRIPDSLFFPNKITCIIILDNLDSPNIPFIEEGGLNQNYALISVKPSGTEILSYRIQVYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRH2</accession>
    <name>A0ABM5KRH2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512789.1">
        <property type="nucleotide sequence ID" value="XM_050656832.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656832.1">
        <property type="protein sequence ID" value="XP_050512789.1"/>
        <property type="gene ID" value="LOC126888495"/>
    </dbReference>
    <dbReference type="GeneID" id="126888495"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="66524" checksum="76806F822B79B080" modified="2025-10-08" version="1">MESLPSTSKEKRWSRPLTEDELLDLLMKDDDSEILRLSDADDANSIADLNDVSSEFGDDIQDIEETIFDGLIQEQKSTERESMTNIAINDLSEDHFSQIELNTERTESLFTEFDEIQMSIELNCQDQDIQQEYAKRQRLDTIFSKTLSRARTMLKRKCSDLSSSQSKRLDISHEYSGLEGVKLPPIQLPVFHGDYLKWIEFKDTFEGLIHNNKVLADIQKYHYLRASLKGDALKIIQSLDFSAQNYNSAWQTLCNRFDNSRMLVNNHLKALFEIENLNKESALGLRSMIDSVKKHLFALKSLQLPTEHWDAIMVYLVSGKLDKFSFREWEKRKIDNSLPSLNEFLEFLKNRADFLETIELSNVTKPDYKSNYQDKRSRSLLTSKSRSCNFCKQNHLIYLCEEFLKLSVTQRWDKIKQLNLCRNCLCTGHSYKQCKSFGCKICKAKHSSLLHENKPSDIHVKENSSINFNPNNDSENEPDKVKLSTNTSENNVNRNEIVLKNNCSNNDYVLLSTAKVRVYDRYGNTHIARVILDSGSQSCFITEDFLMFLINLGDLCLNGLGAVQGGEYGRKVLFIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRY9</accession>
    <name>A0ABM5KRY9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512948.1">
        <property type="nucleotide sequence ID" value="XM_050656991.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656991.1">
        <property type="protein sequence ID" value="XP_050512948.1"/>
        <property type="gene ID" value="LOC126888635"/>
    </dbReference>
    <dbReference type="GeneID" id="126888635"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="183" mass="21639" checksum="3041409BB8C9CB24" modified="2025-10-08" version="1">MEHICTECTLTFSKHSNLRSHLKTFHPDKLDIIAPNKTFKSIVLCNKCPKRFSKYSNLKRHVTKFHPENINELTSSKICPYQCSECQKKFSHLQNLRKHKKIHAKDSDIGKKQQNFKCSLCNYENSIKSNLILDFEEYHAIKIEQQDLHFSSELEFQKWKTNMEKKEFSSYVTYSHPYTTAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS17</accession>
    <name>A0ABM5KS17_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512985.1">
        <property type="nucleotide sequence ID" value="XM_050657028.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657028.1">
        <property type="protein sequence ID" value="XP_050512985.1"/>
        <property type="gene ID" value="LOC126888666"/>
    </dbReference>
    <dbReference type="GeneID" id="126888666"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="254" mass="29101" checksum="3261B1B355077FDE" modified="2025-10-08" version="1">MVTTHLLYPVLIERLKSFDEWIPIHPIKPIVLAVCGYSYTGVNDKVLCVACGVVVNNWLAGDIPLDKHKDDCCFLAAYKQAQRLRDVQTRLDTFPYRCTSVEQHAEFGYFYEDEEVYFLTNKDISLNSVRIATFKNKPGERDPLRVQNDIRSAENGIIYTGPLYRTISSKYCVIVDVYMNEEQETNVVADTSVLHATVANKMIDQRLICKICLLKEINTVTLPCRHATFCRECSHLPRTTCCLCRTPIEYIAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUP7</accession>
    <name>A0ABM5KUP7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513912.1">
        <property type="nucleotide sequence ID" value="XM_050657955.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657955.1">
        <property type="protein sequence ID" value="XP_050513912.1"/>
        <property type="gene ID" value="LOC126889571"/>
    </dbReference>
    <dbReference type="GeneID" id="126889571"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045747385" evidence="1">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="130" mass="13573" checksum="EFE68399D5D5359D" modified="2025-10-08" version="1">MKTLIAVAVLLCVLALVSPSLSLSYGSQDMEERNDGGFMDVLKGFSDILKSIIGLIEGTGKVDDLTAAIQKLFYAVEKLINLQNLLSKVPFVGAYLAPVAGGIGTLMADTPMLGGLISNLLIGPSAADYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXZ0</accession>
    <name>A0ABM5KXZ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515061.1">
        <property type="nucleotide sequence ID" value="XM_050659104.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659104.1">
        <property type="protein sequence ID" value="XP_050515061.1"/>
        <property type="gene ID" value="LOC126890248"/>
    </dbReference>
    <dbReference type="GeneID" id="126890248"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="586"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="766"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1323" mass="150289" checksum="BAA975E3D555D1A9" modified="2025-10-08" version="1">MNIYHQFYHKWALLTDPDDIAGGPKGYLKCDISVIGKGDTVKVPPKSEKDEDDIEANLLLPDGVPTDRQKARVIVKIYRADGLPKMNSSLMANVKKAFTGELNDLVDPYVQVSFAGLMGKTSVKKHSYAPVWNEQLIFTEMFPPLCQRIKIQLRDNDPVKPTVIGTHFIDLKRISNDGEKGFLPTFGPSFIHLYGSTRDYSLIDEHSSLNAGLGEGVSYRARLLISIRTEITDSIDLSPASVDLEPVVPVNEASYAKNEEFFLFACILEASIVDKKLGDKPVYFEISIGNAGNAMDGHNESTRDHYDSDSDELEVVSSDSASWQSTTSPAKPMTHDKTYYFLPYWDNKPCMHIRSVWPDHRRRMYNSNMITKIVEKFEDALSEVTSALEADDSNVEIQFKQVLEDLSVICGKYVTICKASLTGPGTGKTKLDKEHIKLCQREIEQIGVSARNLKALVTKSSFKERFKTAQKFLGKLKFLIDDPQHALPDVFLWIISGGKRQAYQRIPARDIIYSGVEEECGKHCGKVQTMFLKLPGKKGIGPSGWSIPAKLQIFLWLGLLKHKKNFLTGIPGGYEQTHEIKNVERPRALPPSTIHYVEKHIFQLRAHIYQARSLIGSDASGLSDPFARIIAGEFSKTTQVIDETLSPTWDELLIFEEILIYGDGDEIKNDPPPIVIEIFDQDKVGKSEFIGRTLAKPNVKLREDPYTKPKFPPSLEWFTISRGADRAGELLAAFELLEISNEYEGSLPSLPHPKDIPMYHETDPKRVEQLLPVPRGIRPTLVRYRIEVLFWGLRDLKRIHLLTVDKPRVDIECSGNILYSSIIQNRKKNPNFSTPVKFLDLDLPEQELYRPPLTIRAVDCRSFGRYTLVGTHIINSIQRYMYKPMTKKLREAEERKKSLHQLKTGDSNVLSNQVSASNMAVSHNDKERTPLLPKDISIQIGYGTHDGTKKIKAETNKRRKQSFDEEIDDEDENKDWWTKYFASVERMIDESKEAKKFLNQNGNLQVHEEEKSPHSGNSSDKSPGQEHKKRLGFKTVSTASRIAARISPKSTRKRSKYKPALCKIFPTELESRPEYNEFKEWLHTFELYRGKKTGEDAEDDSRVVGYFKGAIRVYKWPLPKDIEDKTIMGFDPQFGLFQGLPSNDPIRVLVRVYIVKANDLHPMDLNGKADPYVVLQLGSKRISDKENYISKQLNPVFGKCFEIEATFPQDSLLIIQVYDWDLVGSDDMVGETKIDLENRFYSRYRASCGLPEVYEEKLLDKIQTSKGQEVLKKSPKLKGKKHKVCHSNNVGLEDVDFMTDEEIKAAKLTGISKKIFSNLVKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY59</accession>
    <name>A0ABM5KY59_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515120.1">
        <property type="nucleotide sequence ID" value="XM_050659163.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659163.1">
        <property type="protein sequence ID" value="XP_050515120.1"/>
        <property type="gene ID" value="LOC126890305"/>
    </dbReference>
    <dbReference type="GeneID" id="126890305"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60951" checksum="B87D6DC278E3C29B" modified="2025-10-08" version="1">MPMKASDFRQLYRKRDIIEQRLNNFIKFIESMTNIAINDLSEDHFSQIEWNTERTESLVTEFDEIQMSIELNCQDQDIQQEYAKRQRLDIIFSKTLSKARTILKRKCSDSSSSESKRLDINHEYSGLEGVKLPPIQLPVFHGDYLTWIEFKDTFEGLIHNNKVLADIQKYHYLRASLKGDALKIIQSLDFSAQNYNSAWQTLCNRFDNSRMLVNNHLKALFEIENLNKESALGLRSMIDSVKKHLFALKSLQLPTEHWDAIMVYLVSGKLDKFSSREWEKRKIDNSLPSLNEFLEFLKNRADFLETIELSNVTKPDYKSNYQDKRSRSLLTSKSRSCNFCKQNHLIYLCEEFLKLSVAQRWDKIKQLNLCRNCLCTGHSYKQCKSFGCKICKAKHSSLLHENKPSDIHVKENSSINFNPNNDSENEPNKVKLSTNTSENNVNRNEIVLKNNCSNNDYVLLSTAKVRVYDRYGNTHIARVILDSGSQSCFITEDFLMFLINLGDLCLNGLGAVQGGEYGRKVLFIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYB2</accession>
    <name>A0ABM5KYB2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laminin subunit gamma-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515179.1">
        <property type="nucleotide sequence ID" value="XM_050659222.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659222.1">
        <property type="protein sequence ID" value="XP_050515179.1"/>
        <property type="gene ID" value="LOC126890352"/>
    </dbReference>
    <dbReference type="GeneID" id="126890352"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF435">
        <property type="entry name" value="LAMININ SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045594446" description="Laminin subunit gamma-1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="388"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="435"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="10">
        <location>
            <begin position="514"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="718"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="876"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="930"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="978"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1400"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="932"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1610" mass="179082" checksum="BAE3842F507B5DD3" modified="2025-10-08" version="1">MWFLRTISLLTLAFSCRGQQTPAIGHGYTPCYDAFNRPQRCIPEFENAAFGLLMEATNTCGQNGDMEYCVQTGVNGIRKSCEICHPGEHDPRYLTDYIHPDSSTWWQSETMYEGIQWPNQVNLTLKFGKAFDITYVRLIFISPRPESFYISKKLTSEGPWIPFQYYSATCRGTYGLPDMTHTKKGEETRALCTSEYSDISPLKDGNVAFGTLEGRPSAYNFDSSPELQEWVTATEIMFTLDRLNTFGDEVFGDNQVLKSYFYAISDIAVGARCKCNGHASECITSTGVDGSKRRVCKCEHNTAGPDCNECLPFYNDAPWGRATAQNAHECKQCNCNGYSNRCYFDQKLYELTGHGGHCLDCVANRDGANCEKCRENYYMREDGYCIACQCNSVGSRSLQCNAEGKCQCKPGVTGEKCDRCEENFFDFSSSGCKTCGCHPAGSFNNQPTCDPYNGMCQCKENVEGKQCNECKPGFFNLDEENAFGCTPCFCYGHSGQCSSASQFSKFVVTSSFFKGTERWNAEDEYQRQIEVKYEPISQSIGVHTVGDEAVYFIAPNRFLGDQRASYNQLLEFTLRIGDNRAVPTATDIILEGSGASVTNTIFAQKNAIPSMQSQVYKFRLHEHPNYGWQPRLPSRSFISILTNLTAIKIKGTYAPEGVGFLDEVKLETASRGVAGKPALWVESCACPTGYVGQFCESCAPGFRHEPALGGSFMPCVPCDCNNHAEICDSETGRCICAHNTAGENCELCARGYFGNALGGTTNDCKPCGCPEGGACIQIDDDLTMCTECPTGYTGHKCDLCSDGYFGDPIGRYGPPSACVECECNKNIDLNAIGNCNTTTGECLRCIYNTGGVQCQECLAGFYGNAVVLPKGDCKPCTCYPVGTEAEKSGAPNCDQTTGTCSCKSHVVGFNCDRCEDGYYNIMSGEGCHACNCDPIGSYNQTCDLLTGQCYCRPGVTGSRCDHCEARKYGFSVDGCKDCECDSIGSKDLQCDPSGQCQCLDNVEGRRCDRCKENKYDRKKGCVDCPDCYTLVQEAYRNHETKLDRLSDILDEIERRPTVIADDEFPKELDKIRANISDFYNKVKNVTGDHSAIQQVHDIRQREKEIDRTLSEIDENMFLIQDRSSITSLNIDHIELNLAEAETRLSETKMAFDTQAKEALDHAIESSKRAGQQSEKMTQIAQDARELADKLDDKANQIADTASTAKNKSIEAYIIAKNATIDQSDVGDKARKLKHEIVDIENKLNRTKEWTAEVANKSVTAKNNALTLLNEVKNLEVPKIDIPELKSKSESLRDQAFKLTNDADALFTDSEDLRRKVDEKNSVGKSLLDTAYEQQFDTDELLNDIHATKEKTDNSIDRWKKMLNDTESIYNDLKDFTSETQKSKQEADEALQTIKDIEVIIRDTLNKTNEARQSLQEATDNANSALEKASQADTLATNASSVAEGIRQEAGQLMRNTTLLSEDAELLKERVEETDKKLNGFLGYAKTNGSFIHEAKEKVGNAGKDTDETSKKVKELLQNVENIINELTNSPNIDDTEINRLEEAIQDTERQLQESQLEDKLIHLQKEHDDQSNLIEQYHIDIQKLQADVDNIEAIVNALPEGCFRRVELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZV3</accession>
    <name>A0ABM5KZV3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515718.1">
        <property type="nucleotide sequence ID" value="XM_050659761.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659761.1">
        <property type="protein sequence ID" value="XP_050515718.1"/>
        <property type="gene ID" value="LOC114333158"/>
    </dbReference>
    <dbReference type="GeneID" id="114333158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
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        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
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        <property type="match status" value="27"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
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            <begin position="742"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="825" mass="97373" checksum="E5CC52CE46CF0FA0" modified="2025-10-08" version="1">MEVQQEIGGKTGNSFEENQEIEKDPLQEKNMDIMKTPNEDSSHEENDMNPQVEGKTLNKNGKKVTHNGKKSQKCEICFKQFIKPSHLKIHLRVHTGEKPYKCELCYKQFSASSGLKVHFRRHTGEKPHKCKICFKQWSTSSHLKRHLRVHTGEKAHKCEVCFKQFSEADNLKTHLRLHTGEKPYKCEICFEQFSTADTLKKHLRVHTGEKPHKCEICLKQFIQAGAYNKHMKVHTKEKTSKCEICFKQFTGTEGLKTHLRTHTEEKPHKCEICFKQFSTTSHVKRHLRVHNRIKPHRCEICFKQFTKPTHLKIHLRVHTGEKPYTCAICFKQFAGKSNLNEHKKIHAKDKAYKCNSCLKQFATKSYLKKHVRIHDAEKPHKCKLCFKQFTIASQLKVHLRVHTGEKPHKCEICFKPFSLKSDLKKHFRIHTGERPHKCEICFKQFTTNSHLKRHVRIHTAEKPHKCEICFKQFATSTDLEMHLRVHTGEKPHKCEICFKQFTKASYLKIHLRWHTGETPYKCEICFKQFTTASHLESHLRVHTRMKPYKCEICLKQFSHAHVLKTHLRVHTGEKPLTCEICSKQFTTSSHLKVHLRVHTGEKSFTCGTCYKQFARKHDLIKHIKVHTKEKDYKCEICFKQFTTASDLKLHLRVHTGEKPHKCEICFKQFTGNLRRHFKVHTGEKPHKCEICFKQFITASEMKVHLKVHTRIKPYKCEICFKQFTTAHYFKIHLRVHTGEKPHKCDICFKQFTTSTDLEIHLKGHSGETAYKCEICFKQFSQTSTLKNHLKIHARENLYECEVCLEEFRERHNLKEHLKVHSKEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L047</accession>
    <name>A0ABM5L047_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515813.1">
        <property type="nucleotide sequence ID" value="XM_050659856.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659856.1">
        <property type="protein sequence ID" value="XP_050515813.1"/>
        <property type="gene ID" value="LOC126890700"/>
    </dbReference>
    <dbReference type="GeneID" id="126890700"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="374"/>
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    </feature>
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</entry>
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            <dbReference type="Proteomes" id="UP001652700"/>
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            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="187" mass="21977" checksum="58E55EC9130B3A8D" modified="2025-10-08" version="1">MDDEKYFTLSNSEMKGNDGLYTNDYENVPDEIKFKSKKKFEDKILVWCAISEAGFISQPYISVVRGEALNANIYIQRCLSKLLQFVNTHHANDQIVFWPDLASCHYARITRDWYETNNITFVRKANNPPNLPQARPIEEFWAILSRKVYNNGWEAQNQEQLRRRIYPKIREIDAEVPKDDATCQGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        </source>
    </evidence>
    <sequence length="246" mass="28879" checksum="9AF0FDFBA18B41DE" modified="2025-10-08" version="1">MKRSRNEHNSSQEEQEFLRESKLVARSPQHKEKVKQPEPSMDEIKQMLRDLKKDLHEDMAQIKREIQNDIREMREDIKDTKKELQKNREEMKSMAKEITQMKEEWTREKEELHNKIKEVEDKMERMEKQKIRNNLTITGLPTNTDNEDTLEEALEKMFQTELLLKTKIRRAQKIGQDRCIVEMTPGLKKMALVRTTDNANQAANMLEEEMAAIISGNRKNTQEENVPNNSSSSTVTNSSPMTATIH</sequence>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="SMART" id="SM00120">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
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            <begin position="258"/>
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        </location>
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            <begin position="53"/>
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            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EnsemblMetazoa" id="XP_050516498.1"/>
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        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37722" checksum="266BF1F751FBA187" modified="2025-10-08" version="1">MYSVYADKIRVLHDDDINAVQYLYGAKSKYAPIPKFTNMHIPTNISTTTILPPSSRQSIHPHHTTPHLTSTTTMRPAPPRQSIHPHHTTLHTPSSTTTRPTTRKQLIFKNLCDIIPDFMFLSTAPEFSNYRLYIAHNKFIWKLDLNGMIIPSQPELLIDYVPTELRQYTLQHIFQTTSGDLLTIVSPNKYFSASFPSIQYIDNFLLNIPNKARINAIFQSNAGRSYTFYNNMSYIEFSNDFMTESGRGKIKDLFPGIPEDISLAFRWTDGHIYFFRRSNYYKFNEFTRKVVAGGQFSWNLFEVPCPNENILYQLKTLLSKLTSIHS</sequence>
</entry>
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    <accession>A0ABM5L2F7</accession>
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            <fullName evidence="3">PH domain-containing protein</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EnsemblMetazoa" id="XP_050516615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20477" checksum="7FEF4059A0977F0D" modified="2025-10-08" version="1">MSKCKIDSLPPTEGVLKQHAYRTYLQLHSWLRHFNLVFKPNSSLTKELNTTDWGWKISKGELIPSSLPDSFEYKVVNFHEINGNDDAFNAVIRANITTQEDAQNWLKEFENINKVNFRVLRTYPNDSVKLVFKKDYRCHHNTQAHLPSSKTKNPSSKHVNCQAFLIITLKQSSMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7M5</accession>
    <name>A0ABM5L7M5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_050662486.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662486.1">
        <property type="protein sequence ID" value="XP_050518443.1"/>
        <property type="gene ID" value="LOC114330479"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="68"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="633" mass="72302" checksum="09C0C412BC3B908F" modified="2025-10-08" version="1">MERTHRKKLMARFSNPKLLAKISAPGTTKKRKITPSFLSHFRVRNSFQASIFDFPPVWTELRRNAQLCDGIVTCGDGREFKIHRAILAAVSPYFKALFTNSINKDHNEVTEAKIMIPSSMFEIILDYAYTGSCTINKSNVKELLKFADQYQLLDVLQMCCNYLIDEICPANCLETMKFASRYFCKELMKVGKLYITRNFPILLTESQEFYNISVDYLKEILKDDELNVRSEEIVFDAVKLWIEYLPEARKENLFELLKCIRVGTLPFESIKCISNWSLIQENPQCQEYLQDVLAVLNGLNQDDHIDYINNYLFRPRVPHEVIFAIGGWCEGSPTNFVETYDCKADKWLFCCDTDTSPRAYHGLCTLNGLIYMIGGFDGTEYFNSVKCFDPVHHEWSQRSCMYFPRCYVSVVVHRGLIYAMGGFNGRLRMNSAERYDPEKNQWELIPPMQKARSDAGAAAVRDKIYIVGGFNGSDVMSSVEVYDTLTRQWSFIQKMSSPRSGVTLITLRNVMYAIGGFNGSTRLSSCEKFDPDILRGWTSIAHMRTPRSNFACVILDGFIVVIGGFNDTGNTGSTTVDLVEYLDADANEWYDAASMSVSRSALSACVVKGLPNTIDYTFLRTEMFMPEIFCNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EX47</accession>
    <name>A0A6P7EX47_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114324158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114324158</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127709.1">
        <property type="nucleotide sequence ID" value="XM_028271908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EX47"/>
    <dbReference type="FunCoup" id="A0A6P7EX47">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271908.2">
        <property type="protein sequence ID" value="XP_028127709.1"/>
        <property type="gene ID" value="LOC114324158"/>
    </dbReference>
    <dbReference type="GeneID" id="114324158"/>
    <dbReference type="KEGG" id="dvv:114324158"/>
    <dbReference type="InParanoid" id="A0A6P7EX47"/>
    <dbReference type="OrthoDB" id="8251120at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF374">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028127709.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42116" checksum="47D9FF3E51AE5D76" modified="2020-12-02" version="1">MEDRLNNIKNYFKKKSNDSEFVQRFGGVPQIGFRISFCESTKELKVKVIGARQLPTDYGNVKPQGYLVKVTFYPSKQKFETKTAKDSWPTINEEFSCILLPVKRIDDFFKGQFISFTVYATLGKEEEEQRQKEKPKSILKRYFSFSDGEEIISLRNNSFRRSGSQRRSSYNNSLSNRRTVGAVTYNLDRKLFTQKLRTGEISTPDIWRNITEITSGIQTQPRDGPKGSIELTLQYGVSEDGTNDVVEVTVTKFRCSLQTMQLHEKIGGQLYIKITAFEDEDLVQKMKSDKFEPTISLKLEANTSTLRATVDKYNLEDMKILIRLMSRNIVGKKTLLGKIEIDRNSSFWKEIVANPSVAITKMVNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F314</accession>
    <name>A0A6P7F314_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114325811</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028129736.1">
        <property type="nucleotide sequence ID" value="XM_028273935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F314"/>
    <dbReference type="FunCoup" id="A0A6P7F314">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273935.2">
        <property type="protein sequence ID" value="XP_028129736.1"/>
        <property type="gene ID" value="LOC114325811"/>
    </dbReference>
    <dbReference type="GeneID" id="114325811"/>
    <dbReference type="KEGG" id="dvv:114325811"/>
    <dbReference type="InParanoid" id="A0A6P7F314"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027768766" description="alpha-glucosidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="36"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028129736.1"/>
        </source>
    </evidence>
    <sequence length="571" mass="65371" checksum="4CFCEF54CF5A4536" modified="2020-12-02" version="1">MLRCALLFSAILAISLVNARGLVEDKDWWKTATFYQIYPKSFKDSNGDGIGDLEGIIQKLDYLADLGITGIWLSPIYKSPLIDEGYDISDFRDINPLFGDLKTFVRLVEGAHSRGLRVVLDYVPNHTSDQHEWFKKSENGEEGYEDYFLWIDSKDGSKTDLPNNWISVFKNSVWEWSDKRNKFYLHQFFKQQPDLNFFNEKVRKEMRDILNYWLEEYGVDGVRIDAVPHLVEAKNLTNEPRTYDPNASPNEYDYLDHIFTRNQPESYDLVYEWRSHIDGISKNTSQTKICMTEAAVDLKYVVPYYGTADGSKLGAHFSFNFVLLGLETTSTAADVASLIHAWVDKLPKIYTSNWVLGNHDNHRIATKAGKERVDCLNMLSAFLPGIQVTYNGEEIGMENGEVDCETQGLDHAENCTDYYKISRDFERTPFQWDSSEFAGFTDGKKTWLPVSSKKAECNAKDQLKDEKSHLSIYKKLQRLRPQWRQSEYEVKTLDEAQNVLQVVRYNEGGSNEAQLVFNFGSEPIKGINLNRGNSYEVVISSGKSLRNAGDEVDGKSLSLDAYEALILKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F412</accession>
    <name>A0A6P7F412_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAGUK p55 subfamily member 7 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114324565</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128230.1">
        <property type="nucleotide sequence ID" value="XM_028272429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F412"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272429.2">
        <property type="protein sequence ID" value="XP_028128230.1"/>
        <property type="gene ID" value="LOC114324565"/>
    </dbReference>
    <dbReference type="GeneID" id="114324565"/>
    <dbReference type="KEGG" id="dvv:114324565"/>
    <dbReference type="CTD" id="36176"/>
    <dbReference type="OrthoDB" id="439127at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="7">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="139"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="347"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028128230.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="62412" checksum="B4100334D7B4C8FE" modified="2020-12-02" version="1">MANGTKEKWDPALTRLLNSLQHASNLPSTDEELGFLSTLLQSKELHALVNVHNKIISNGASDKFFPMLSTSMDILTDVLEELVRKPYMSEDCKELFYLLQKPHIQGLLYSHDSVAQKDYYPHLPEIPRDTEEDEETIKIVQLVKSNEPLAGAQSAEPVVGATIKTDETTGKIVIARVMHGGAADRSGLIHPGDEVVEVNNITVEGKTPNDVLQILQNSEGTITFKLVPADSKSGARESKVRVRAHFIYDSSVDPYIPCKEAGLDFVKGDVLHIVSQDDAYWWQARKEGDRNMRAGLIPSRALQERRIIHDRTQTNKNGEDAENDDFDREQLATYEEVAKLYPRPGMYRPIVLIGAPGIGRNELKRRLIDTNPGKYRTPTPFTTRQMKPGEEDGKEYFFVAREIMEKDIEDGKFIEFGEYKGNLYGTSAESVKAIVNAGKVCILNPHYQALKMLRTPQLKPYIIYIKPPSLEILKDTRNACHARSTFDINNSRGFTEDEFNDIIRSATRIEFLYDHFFDETIVNADLAIAFSQLVSAANRLETEPLWVPGSWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6K0</accession>
    <name>A0A6P7F6K0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton-coupled amino acid transporter-like protein CG1139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326332</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130462.1">
        <property type="nucleotide sequence ID" value="XM_028274661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6K0"/>
    <dbReference type="FunCoup" id="A0A6P7F6K0">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274661.2">
        <property type="protein sequence ID" value="XP_028130462.1"/>
        <property type="gene ID" value="LOC114326332"/>
    </dbReference>
    <dbReference type="GeneID" id="114326332"/>
    <dbReference type="KEGG" id="dvv:114326332"/>
    <dbReference type="InParanoid" id="A0A6P7F6K0"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="73"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130462.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54200" checksum="69D6A5BB03679DDF" modified="2020-12-02" version="1">MDIFSDLYDLHEVHLYTVLCSFVQEPRSKPSSSKSEEKQHLLDGEFQQESSAVTVEDSTNMYEEFCFNRTIEHPTSNFDTMIHLLKANIGTGILAMPDAFRNSGWVVGLFGTLCMGIICTHCMHMLVKCSHELCRRTQAPSLSFSEVVENSFKTGPEFLQKYSSLAKSLINIFLCITQLGFCCVYFVFVAVNLHDIIKHFWMDIGTPWYLLFLLAPMVMLNCVRSLKYLTPASLFASIATCMGLVITFFYIFQGGLPNTSTIKAFSSWEQLPLYFGTAIYAFEGIGVVLPLENNMKNPQDFSGWNGVLNTGMVIVAALYTAIGFFGYLKYGEKAVLGSVTLLLPPDEYLAQLVRLMMAVAIFLSYSLQFYVVFHIIWPWIQTHFKTDKSREVAEYSLRAILVFITFVIAIAIPNLGAVISLVGAFSSSALALIFPPIIEIITFWPDKLGQGRWVLWKDIFIIVFGVLGFIVGSYVSLLNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FA21</accession>
    <name>A0A6P7FA21_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326321</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130453.1">
        <property type="nucleotide sequence ID" value="XM_028274652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FA21"/>
    <dbReference type="FunCoup" id="A0A6P7FA21">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274652.2">
        <property type="protein sequence ID" value="XP_028130453.1"/>
        <property type="gene ID" value="LOC114326321"/>
    </dbReference>
    <dbReference type="GeneID" id="114326321"/>
    <dbReference type="KEGG" id="dvv:114326321"/>
    <dbReference type="InParanoid" id="A0A6P7FA21"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130453.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46393" checksum="046935743C6B4A1F" modified="2020-12-02" version="1">MKLSTQEKRELDKFTKFLALKCTQIIVQSRLGEKVTSNCRSQTTSTDWFNLNISDLPEVLAETKRVLNGEILSSNLPLCVEISLRTVEGDHMVLENWCLGMLPEQQCDPTTRIVHTIYNRMGTLLKSLVSITRVVPAYKLSRRQGPDSFVICYRIFLGEPLIQCLGEDFNKVQIGQICTPIGTLNLSVSYRTKMTISPTQTGRQNSIMLKSDHFNTKMSPKSRRNNQKEDKTISLEIPMRRGAFANQYKKLETVYLIPKLPYSRINPPPPPKKPVEKKEEESETDGSASTSSADSKKMDNESTEEKNGNKMTDNLANKLEKLTMESTNDDENNFVMVDLKAPFASRTTKTTELGEFFRYCQRAPKTLQVFAEIPPLDESIINRQLETFEADAPEYDAMVQSICQSSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB96</accession>
    <name>A0A6P7FB96_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ER lumen protein-retaining receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114326529</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130725.1">
        <property type="nucleotide sequence ID" value="XM_028274924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB96"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274924.2">
        <property type="protein sequence ID" value="XP_028130725.1"/>
        <property type="gene ID" value="LOC114326529"/>
    </dbReference>
    <dbReference type="GeneID" id="114326529"/>
    <dbReference type="KEGG" id="dvv:114326529"/>
    <dbReference type="InParanoid" id="A0A6P7FB96"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028130725.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28669" checksum="40B30409D1BF6F7E" modified="2020-12-02" version="1">MYPVPEFFPVVEILHTFAMCFLPVSIILKQNGADVSGKTQLLQAMVVITRYVHPYDTFGYADWTSMTKGLQIMATVFTVFILFVVMDSYDTKSDIFTAEILVFTAMYLALHFPIKMDSYWILWQFSEYLEAVSLLPQVYLVIKIQNISMGTAVFMTFMAISKLFYIFTWLISHKTNVELFYVTHISAIIHVGIFISFLILGICTAAANSSTTKSSKMGYAVVDVGNVVKNVSQKPGKKDQATDRTPLILYSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FC88</accession>
    <name>A0A6P7FC88_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114328825 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114328825</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133569.1">
        <property type="nucleotide sequence ID" value="XM_028277768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FC88"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277768.2">
        <property type="protein sequence ID" value="XP_028133569.1"/>
        <property type="gene ID" value="LOC114328825"/>
    </dbReference>
    <dbReference type="GeneID" id="114328825"/>
    <dbReference type="KEGG" id="dvv:114328825"/>
    <dbReference type="InParanoid" id="A0A6P7FC88"/>
    <dbReference type="OrthoDB" id="6780143at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028133569.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14738" checksum="B507408230D39AB0" modified="2020-12-02" version="1">MGDNNNGSNGYPFYPTYLTIPPINTDDDPIDIGKILIPTFVLIGLVVATQVFFIFLNTHIVKAFRKEVIRRGRLISVLPIISTIGATMPVHVNVQQTVNVPNAPQQNTYPPNAYTAPDGSRMFDDKVAPPAYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCQ4</accession>
    <name>A0A6P7FCQ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114328969</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028133769.1">
        <property type="nucleotide sequence ID" value="XM_028277968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCQ4"/>
    <dbReference type="FunCoup" id="A0A6P7FCQ4">
        <property type="interactions" value="1402"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277968.2">
        <property type="protein sequence ID" value="XP_028133769.1"/>
        <property type="gene ID" value="LOC114328969"/>
    </dbReference>
    <dbReference type="GeneID" id="114328969"/>
    <dbReference type="KEGG" id="dvv:114328969"/>
    <dbReference type="CTD" id="4175"/>
    <dbReference type="InParanoid" id="A0A6P7FCQ4"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="338"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028133769.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="91046" checksum="C447EBBC39A74C48" modified="2020-12-02" version="1">MDVADINIGQRQHRDEIGIRCQKLFQDFLEEYKEEGELKYLEPAVELHSEERSTIEISFEDIEKYNQNLATTIIEEYFRIYPYLCQAVSNFVKDRAGLKNEKECYISLMDVPTRHKVRELKTDKIGTLVRISGQVIRTHPVHPELISGTFTCVECQTVIKNVEQQFKFTNPTICRNPVCSNRRKFLLNVDKSRFVDFQKVRIQETQAELPRGCVPRSVEVILRAENVETVQAGDRYDFTGTLIVVPDVGAFALPGGQTQSRSKNRRPEESEGVRGLKALGVRDLHYRMAFLACSVQPTIPKFGGIDMPLGEITPEIMKQQMTEGEWAHMYEMSHDKNLYVNMINSLFPSIHGNEEVKKGILLMLFGGVSKTTVEGTSLRGDINCCIVGDPSTAKSQFLKQVSEFSPRAVYTSGKASTAAGLTAAVVKDEESSDFVIEAGALMLADNGVCCIDEFDKMDLRDQVAIHEAMEQQTISIAKAGVRATLNARTSILAAANPVGGRYDRAKSLQQNINLSAPIMSRFDLFFILVDECNEVIDYAIARKIVDLHCNIEESVERVYTKQEVLQYISFARKFKPIINKEAGDLLVHYYNRLRLRDSSSTGKSTWRITVRQLESMIRLSEAMARMDISDEVQTKHVREAYRLLNKSIIRVEQPDIELGRDEKDDAAPEVENSETMATDTPEPTPTVTKKKMLLSFEEYKTISNMIIIHMRREESRMEAEGKDGIHRSDVVEWYLNQVADQIENEEELIEKKDMFEKVLDRLMYIDQIIIPLSRVGLKGADQEEEEDPMLVVHPNYVIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDV7</accession>
    <name>A0A6P7FDV7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 11-A, mitochondrial isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114327214</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131550.1">
        <property type="nucleotide sequence ID" value="XM_028275749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDV7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275749.2">
        <property type="protein sequence ID" value="XP_028131550.1"/>
        <property type="gene ID" value="LOC114327214"/>
    </dbReference>
    <dbReference type="GeneID" id="114327214"/>
    <dbReference type="KEGG" id="dvv:114327214"/>
    <dbReference type="CTD" id="3772100"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028131550.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19562" checksum="E9973AF3FC879E00" modified="2020-12-02" version="1">MDTGERSLHSTNVAVIREVYDNEFSQACFSMELEKALESRCSIIVIEPTQLGDETARWISFGNYLHKTAVISGLTSIISGFAWPDTFVPQAPLSIISSLCTGLYTVSWQFDHCVKYQVERDVRKLSRLPILGALTSASPVVLVRKDNTKRIIVHWAVTLASASLCIYRLYRTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEZ3</accession>
    <name>A0A6P7FEZ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">LIM/homeobox protein Awh isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114329623</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="18">Whole insect</tissue>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
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<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
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        <location>
            <begin position="1889"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2058"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2069"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2571"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2586"/>
            <end position="2617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133091.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028133093.1"/>
        </source>
    </evidence>
    <sequence length="3928" mass="447108" checksum="7758D5FB378D30D7" modified="2020-12-02" version="1">MSDEDYNKKMEGLQKYIPFLENMIIQLKDPNKKNREQQLNKMESLYAMITDKKKKLKVETLNKCEDVISKLYIKVNHKSIESDNETTRTISISPSFSDNSTASSIPSERVLNDKGDDYTSKREGERSLKSDEQKRNLSRGKTTEISKPPISLDDLKCLEVDVQEKINEAASLKELTEKRNKIATELMFENIKSMNKDKKHDSKKSRSKSDHNIKLDRDVRASSNERHSKKSKEPAVPKVPSKIVKEVTSGFASTLSDIDDKIKEVNRKREERSSGFGSTVSDIDDKIKEVNRKREERSSGFGSTLSDIDDKIKEVNRKREERSSGFGSTLSDMDDKIRELNRKREERSSGFASTLSDIDDKIREVNRKREERRNAYLKDEKNKTQVQKLKEQTEKEGNRTSESNNYNKDVKNLIKFEIKRLEDPRIKHLANPLKQEASKTNANNLKDSKTEHEVDTASLKRLAEKYSQKPRIADEVDKSITKSIEQSMKLSPQISPVIYRLSDPPPPPPASLVKCSQLEPQLPPFKPPLPTLTHNPVLRGSHPTARTHPQGPNILLSPRENFLSHPSPSPLMSPRETFASNTQLASPRDNFHANSSVPMSPRDNFHAHSSVPMSPRDNFHANSSVPMSPRDNFHGNSSVPMSPRDSFLSPRETVSISPRDNFVSEYVREEFNSRRPRVDQTSPIMSPNNVHVTPNMPQRYNQPFNNFNQMEPPRLDYYPQNICPSPQYNHIPPLLSADASHYQDQKPFQNVNPYGVVNREPYAPNDLRWRIGDNRHWERRDFKPRFGGPMTYREHREMRENSRDPRVVRDTRERDSKDVKDIRDPRLNREGSVNRENTVTKQTLDAAEKINRDPRLNRGRSSSREDSKFDRLYSRTNRNRSRSRSRSSTRTEVIEGDTFSSPLDSLYNSREEQKSGKGYGVQSFRIPKKKKDEKEKAKEPEVETSKETISQDEEGHDYSNKTIDISDNEEDSKTSVNCVDNKESVPVSTLIETKIKSDPNKNLNKEEIHNSSVCIDNDVLEVTSTTMDISSPVYKEEESQPSVSEEQTKSDVTDDKKAENISNSQDSKTSTKIEEPVKPPVTEQTILAQFFANLLGSQNKKEKKTALYSLISTFSDSFSPKELGKITKIIHAKEEDQDSSDEELSQKPSVSNTEEGNSQKEAVEEDKVTQEQNADDTADEKIIPKRKLRQRKTPSSVKQNIVEENIGEQNIGEQNTSEIEVDNDVSLSENVLSSENLLEKTGDQLDKESGVLVSVGERTKSRKRTATLGNKARKKARSELDKLHDDIQEMFIRDGVLTASGKRMCHMLKDDKFAMNSENVECNAEEIVTKPGKKPQPKNKNQNKKKTETELKTMKHIRVIIQKIPDTSVDESEASRRFTRSMTVTESDDESSISTGVSMSNRNSDIEDADSRSDKEDDNLSTGDSHKLKSSKRKRPRSNWAAGIIKKKKKKQNLDELTKLKLPEIEISPNESLLPTKELLLPTKELLLPTKEFWIDFSLQKKFYSCKLCNFQGRYITTHYKVEHPDSEVLSARFSPALADEAIADAQMNMEKYDKYQVVKSTKISYVCRFCKFTTTVLPTQFYDHLTTHTGEYRHVCTHCPVSFCTSKSFKAHVNSNHQGADDKPVVRKVFNDVIIFGYLCAECNYVQTNKQTIEQHIKKYHSGETPIHKINLSTIFDKQIEKFCEPKKSIEENSSSSTIVHNINDAEATENDMTSSELPSSDIAPWMKKYKSKPGPKPKKKVERRKSTSVALPSISEPLEVTKAPNIRRGINSDIDLDKILPVRSKRAAKEKAQEKLKEIMEMTDVPSKKKTDEKLTNDSSGANDISDKPTKDSSSLDDISDKPTKDSSSLDDISDKPTKESSCLNDISEKTAMDSSCSNDISDKPTDSQSTNNENISVNEKTNQKEEKVSPVKIKAEVIKKDLDMSMFTSKIDIKEEKDKPEQDRLSKIDDLNVTHENRTSLNFVDKVCDRINLSEISIKQEQPEEFIENVHHTVNESPNTMPVLEKIVFTSTPAPKINSEPITEQTIETPKSALGVSKKNDNSIINILEKLQGRSSDNHFSNNPFSDDDANDNEDPPPLIHVNELTELSPSIKVLEVCGLIKVIKTDQLSTFYCLVDLCSFSTENKDSFQKHCKENHLALDFKKSNVCETCGVEIISSSDGSLLENLFKHTITDHSDYIYSEEVNENRTSTAPKPQMIRLRKLSGDALSNNQNSEKEKPDESVICNTEKHVGVSETTIINARDIKTNEVENNPFPFKIAEVVSLAETPENPPPLTPINKPLQLVVKEAKLTSTELAKPRKSTKAISKFIKEVEKLYKCPQYYCLFSSDSGDELQQHVNTVCSRTADKDSMVPCVYCDLKTPWEHLVVHIDIRHANCKYACPYCLYRACLKSYVTLHQERVHPYQKFSVLTVNSNKTQKKFTITDAKLDPKMLCKPYRCIPGCNLEFLFENEFSDHVKEAHKNNFFTCGHESCTSRVTHAKLLQHWSMSHNVSVYQCGYCTSNSCEIKTMYHHLSNIHPNLYPEILFRFISPKMPHNVFNTPEAFTKIRKIVNITNTISDNTELKLKLPNSPSLLVSPPKSSPYADSNINSADANRSPALPTTSSLIPSKSSTPLTDPLDIDTLIEMPSPTALSDKKLQNIMIEESPSSKQKPSVEPMPETSLEQISFSGGTQGEKSRECDVDPLELGESVNSQNFGDSSEDENDKSKKKFGLLGYQLFRCAACEFSCSNLNDFKKHIAKSLLCKDKDNSNKPFVCVHCKKSFRNSNILCDHIQCHGILRYSCSLCGNKFPTFRQGRGHMKHRHNVNQTTQTVLNSTIASNGEEYIIKPKLLIADPPAKENISSEPSSPISTPEHVYNPGDINKIPMRSIFSSDLRCGTCSYTTKVRTNLIRHLQFHSQEISVPDTAPVNPVPCLGKNEKMFDKMVNLASSSHTSSMRMGGAKLDKKDDDKFPDFVPSSSRYTCCAKGCNYICPEEGNLRHHLIALHSEELKFTCVHCKMKLNHADADNIIKHLKLHGLQLYKCHYCDFVHNLKHKIDRHITEYHNDLALKVITLRCLESEPKDIEDEENAHPVSTPVSSKFSKPWRCCMCKSKTVTQDGIRNHVLEKHDIDSQFKCALCIYKSNDLITFPGHYKEHHSNQEVNIIQVYCKIEEENKDDKDTDVFDTTPLWQRDRPRVRHIRGILFDESTPVPTKSLKKATKGSAVTPTKKITQMESAVPVQPTPSLKSDTDELIEEINQLIKRDLDDDVIIIDDDEVRPQTITTYRRKTIDSPEFKKIDIDEHGNVESSKIDDDFSEHSLLDTFGSFGLPFLKQLKCPKCNKFKSKRISDFIFHMFKEKEINRYACKICSDVSVTYKYMYKHVLQHQQQFDINNIISLPKNPRLEIWLQNLIRMQCNIIVRSLAAPKEISPNSTPHKVLCRYCNKWYRSEQERNEHAIFHWKCIPFKCSECSFEAYTRTHMTLHITLPHGRGKTPFIIAAGPTVAGELQYSDFLHMKEAEEEKEKSKLTTSLNPPTKVNQTAIAQVLVPEVVRPDMIDESEQDGTVQGMVFLDESNDKVSVEVADDHHEPSDALDISDLLIVSKTDTNVPNDGDVFCCEYCPYMSHSEMQIRSHISGQHDHMHIKFKVLNRPQCESKKDDYVACTICNEVGSEITIREHHLDVHEGETFFIYRYICCCCQKRFTKFHGIRIHFNRRHPGVQLKCKDIFNKIHYFEPVKTKVSEPSIRKNVAPLSLSGSKKEWKHYKCSLCRYERDFTSNGIGNVRTHVRNHFKAYICGTCGIKLKSKTDGSFHYKKEHPNVEENIIHDEAIEALYVSTMATICKTAVSVPEPSARSVPSAVIKKHTARKSTSKPSTLPMEEFSFYGNTVEDVDLNKIMSSVEINGMHLDMSAERLGTLFNLHPSLILERCDAHVDESNEIVTIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJQ7</accession>
    <name>A0A6P7FJQ7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Sodium/potassium/calcium exchanger 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114328551</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133223.1">
        <property type="nucleotide sequence ID" value="XM_028277422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJQ7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277422.1">
        <property type="protein sequence ID" value="XP_028133223.1"/>
        <property type="gene ID" value="LOC114328551"/>
    </dbReference>
    <dbReference type="GeneID" id="114328551"/>
    <dbReference type="KEGG" id="dvv:114328551"/>
    <dbReference type="InParanoid" id="A0A6P7FJQ7"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="276"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028133223.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49350" checksum="11CEA69D73679728" modified="2020-12-02" version="1">MDRNCTPPAINEFPKDLFSKTTREHGAVLIHIFVTIYLFTALAMICDEYFVPAVERICHVLKIPHDIGGATFMATATSSPELFVNIVGTFITEGDIGLGTIVGSAVFNILAVTACCGFTTAAVGGNKLKLDWWPLTRDSLIYGISVCLLIIFLNNEKVEWYEALILVLVYIVYLVFLIFDKFIQQFFKENFCQNCLSQSNTTCDNTIPKISSNLETSKKDETKDESEEKNDITLWKYPSEISKIRQVIWIITWPINFAFFLTVPHCEKVKSNKWIPVAFVMCILWIGMLSYILSWMITVIGDTLRIPDSVMGISFLAIGAGVPEAVSSIVVVKKGKGAMGISNSLGSNTFDILLCLGVPWLLKATVVSSNKWVNINSSGLQYSTVTLLVTLIAFYFALTCNKFKLDKWIGLYCLIIYILFVILATLIELNVFFPVNSPTCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK42</accession>
    <name>A0A6P7FK42_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114331209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114331209</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136504.1">
        <property type="nucleotide sequence ID" value="XM_028280703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK42"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280703.2">
        <property type="protein sequence ID" value="XP_028136504.1"/>
        <property type="gene ID" value="LOC114331209"/>
    </dbReference>
    <dbReference type="GeneID" id="114331209"/>
    <dbReference type="KEGG" id="dvv:114331209"/>
    <dbReference type="InParanoid" id="A0A6P7FK42"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028136504.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="27563" checksum="D9B3517133408D20" modified="2020-12-02" version="1">MSISFKGKVVLVSGGSSGLGGATAKRFGRLGANVAIAHKNIPGDTIEEVVAEISKFSTPLVIECDLTDSKQIEHVVNQTVKHFGKIDVLVNAAGILQNGSIENTTLEMFDKVMNINVRAMFEMIRVCTPHLIKTQGAIVNISSVTGLRAFPGVLAYCISKSAVDQLTRCVALELASKQVRCNSVNPGVIDTILHKRSGLNDEQYKAFLEKSRLTHALGRAGTAEEVASGITFLASTDASFVTGNNFRIDGGRGIMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKQ7</accession>
    <name>A0A6P7FKQ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114328766</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133528.1">
        <property type="nucleotide sequence ID" value="XM_028277727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKQ7"/>
    <dbReference type="FunCoup" id="A0A6P7FKQ7">
        <property type="interactions" value="1265"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277727.2">
        <property type="protein sequence ID" value="XP_028133528.1"/>
        <property type="gene ID" value="LOC114328766"/>
    </dbReference>
    <dbReference type="GeneID" id="114328766"/>
    <dbReference type="KEGG" id="dvv:114328766"/>
    <dbReference type="InParanoid" id="A0A6P7FKQ7"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028133528.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="51727" checksum="89DAEC191E6E4FA4" modified="2020-12-02" version="1">MALFRRLTPTKLSETPKLKSQVAVVLRQLSDSSTDLKAVLAAKIPKEQERVKNFRKQHGGSKVGEVTVDMMYGGMRGIKALVTETSVLDPDEGIRFRGLSIPECQNVLPKAPGGSEPLPEGLFWLLLTGDVPTEAQVKALSKEWAERAELPSHVVQVLNSLPTSVHPMSQLSAAITVMNSESKYAKAYASGVHKSKYWEYTYEDAMDLIAKLPVVAATIYRNSFRDGSGIGAIDTSKDWSYNFTTMLGYDDPKFIELMRLYLTIHSDHEGGNVSAHTVHLVGSALSDPYLSFSAGMNGLAGPLHGLANQEVLVWLQKLRQQVGDRATEDQLKDFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPDDPLFQLVSNVYKVVPPILLELGKVKNPWPNVDAHSGVLLQYYGLKEMNYYTVLFGVSRALGVMASLIWDRALGLPIERPKSMSTDGLMKLLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLD0</accession>
    <name>A0A6P7FLD0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinol dehydrogenase 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328973</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133778.1">
        <property type="nucleotide sequence ID" value="XM_028277977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLD0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277977.2">
        <property type="protein sequence ID" value="XP_028133778.1"/>
        <property type="gene ID" value="LOC114328973"/>
    </dbReference>
    <dbReference type="GeneID" id="114328973"/>
    <dbReference type="KEGG" id="dvv:114328973"/>
    <dbReference type="InParanoid" id="A0A6P7FLD0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028133778.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34629" checksum="6E546313C3DB17BA" modified="2020-12-02" version="1">MLYIVLYSIGAYLIFNLVFKIYVKLNTMSCKNKVCLVGKTVIVTGANTGIGFETALDCAKRGARVILACRDHLKGTVAVQNIQTLTKNQNVVLKILDLASLSSVKNFANDILRTEEKLDILINNAGALLLGDQLTEDGLQFEMQINYFGPVLLTLMLVNLLKKSAPSRIINVSSVVAKYAKLDVKNLNGKPSYPITKLCNILFTQELAKKLNEFNISVFALHPGMIATDIMTRHLWPIVNSCVIPLSRVVIKTPEEGAQTTIYAATEPGIEHLTGGFFSECRYQKHYKTARDPQLAQQLWDETMKLLNYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMP0</accession>
    <name>A0A6P7FMP0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mast cell protease 1A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114329382</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134263.1">
        <property type="nucleotide sequence ID" value="XM_028278462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMP0"/>
    <dbReference type="FunCoup" id="A0A6P7FMP0">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278462.2">
        <property type="protein sequence ID" value="XP_028134263.1"/>
        <property type="gene ID" value="LOC114329382"/>
    </dbReference>
    <dbReference type="GeneID" id="114329382"/>
    <dbReference type="KEGG" id="dvv:114329382"/>
    <dbReference type="InParanoid" id="A0A6P7FMP0"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027833423" evidence="3">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="32"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028134263.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28285" checksum="9F9DCA5F0528F9B4" modified="2020-12-02" version="1">MFKMRNFTWCITLLICTLLVNNNPLADNHLRIIGGYEAKIEDHPWIVLLESKLGYFSYSCGGSLLNEDTVLTAAHCFNHSKQWSIYSILAGTHDITQPGMKIQVKDVKIHEYYRSSMGINNDIAIVKLAQKVEFSNKIQPARLPNQDDQLPEGAPLLAAGWGKTKMNVPKGSDVLKAVRMEVLPQETCTNEGWLNKVICAGDIINGAAYEGDSGGPLEYDGVVVGVSSYGVGPFLCGAFTSVADYRRWIDETIHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FN95</accession>
    <name>A0A6P7FN95_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Double-stranded RNA-binding protein Staufen homolog 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329549</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134495.1">
        <property type="nucleotide sequence ID" value="XM_028278694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FN95"/>
    <dbReference type="FunCoup" id="A0A6P7FN95">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278694.2">
        <property type="protein sequence ID" value="XP_028134495.1"/>
        <property type="gene ID" value="LOC114329549"/>
    </dbReference>
    <dbReference type="GeneID" id="114329549"/>
    <dbReference type="KEGG" id="dvv:114329549"/>
    <dbReference type="InParanoid" id="A0A6P7FN95"/>
    <dbReference type="OrthoDB" id="10037267at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19857">
        <property type="entry name" value="DSRM_STAU_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19858">
        <property type="entry name" value="DSRM_STAU_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19859">
        <property type="entry name" value="DSRM_STAU_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19860">
        <property type="entry name" value="DSRM_STAU_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19861">
        <property type="entry name" value="DSRM_STAU_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000073">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="367"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="477"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="712"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134495.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="82156" checksum="9EF9C3A58C5B7F1D" modified="2020-12-02" version="1">MLQDHHHMSQNGMQRNARMGMQQMGPPPNQRTPMLMSMPATGVLVSMPPGPGPTLITTTSIPQQPQPKANIQQPVYHYENAGQPTEPDQHSTEHQNCSNTNTLSTPNATLANIKEKTPMCLVNELARYNKIQHQYRLTGEQGPAHKKIFTVTLKLGNEEYEAEGPSIKKAQHSAAAQALAKTEFKHPPPKTVRNRPGTRPTNPGVVTPTVELNALAMKRGERTVYVVENGGAPPHQNYVTQPGYYPRHNLYNAQTQPQRYTYDARRNIRGHYPYHENRYYGQFRPGAPHNPGDPYTVRLRVGEREYPGQGYTVQAARHDAASKAIEHIKQLGTSDQSDGDISPDVTQQISNDSAQGSLSDINSDLKSPISLVYEIALKRNLNVHFEVLSEKGPPHMKVFITQCCVGSFIAEGEGNGKKISKKRAAEKMLEQLSKLPPLPNVTNIAQLKKKRVTNKKKTRNLIKVNTDRSTEVVEEINPISRLIQIQQANKEREPVYTVLEERGAPRRREFVIEASVAGHSCTGVGPNKKVAKRNAAEALLIDLGYSNTNINNVKPIAKDKEEGVAPNIHPNMDKNRKVTFVEEVPEVQPTQSVGGSGGRQLVPGILLVTEQSGFPKPKDTMDKPVQQPPTQIKPPSTIQGVRSKDKLLYLAQLMNIQVQFSDFPKANHEMYLTLVSLSTNPPQVCHGEGPTTEASHEKAALEALKALSELGLDIAPKDGSGGPNGNENASPVVSNKGPVHQNGVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTB2</accession>
    <name>A0A6P7FTB2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Death-associated inhibitor of apoptosis 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114333756</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139551.1">
        <property type="nucleotide sequence ID" value="XM_028283750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTB2"/>
    <dbReference type="FunCoup" id="A0A6P7FTB2">
        <property type="interactions" value="2046"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659668.1">
        <property type="protein sequence ID" value="XP_050515625.1"/>
        <property type="gene ID" value="LOC126890594"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FTB2"/>
    <dbReference type="OrthoDB" id="774873at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089720">
        <property type="term" value="F:caspase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022416">
        <property type="term" value="P:chaeta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16713">
        <property type="entry name" value="RING-HC_BIRC2_3_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14321">
        <property type="entry name" value="UBA_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000184">
        <property type="entry name" value="Baculoviral IAP repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028139551.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58909" checksum="0A06C1D920FC047E" modified="2020-12-02" version="1">MHQEINRLQTFSEWPSDAQVSPQRIAKAGFFATKQGLEVECFACHAKISEWNYGDQVMTRHIALNRDCPFVLNPSTSGNVPITSSRVPSTSINMYRSSETRLASFENWPAADIVTPDSLVQAGFYYLKEGDNTQCAFCKGVVRAWEVGDDPDTEHQRHFPNCPFVMAVINPRLQARRGSNDRNNPENNQIVKDSFPNINVVGTEQNLGELGVQAHRGPKKSNFATVEARLRSYVGWSSDLIQTPEVLAEAGFYYEGMGDQVRCFHCDGGLRTWDPHDDPWTEHARWFPNCSFVKLVKGQDFVTACTIGQTTDSSVRPSAQRIQTTRIRREVTEREIQSYLTSPQALAALSIGLNVERVKRAIREKLEQTGRAYSQPDALVEAALNLQHEEEDPNSHEHYTPIDRSLRNVVCAAMEECIDRQPEQVQQPEPAQQPEMDEAFEVSPTTAPDGTPQLHYQLVKTVSLEEENRILKEARLCKICMDSEVGIVFLPCGHLATCVNCAPNLEDCPVCRSTIKATVRTFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUX9</accession>
    <name>A0A6P7FUX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="9">dUTPase</shortName>
            <ecNumber evidence="9">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114331246</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028136545.1">
        <property type="nucleotide sequence ID" value="XM_028280744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUX9"/>
    <dbReference type="FunCoup" id="A0A6P7FUX9">
        <property type="interactions" value="1920"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644336.1">
        <property type="protein sequence ID" value="XP_050500293.1"/>
        <property type="gene ID" value="LOC126880475"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FUX9"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="10">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028136545.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18097" checksum="107B14557DAE5F6C" modified="2020-12-02" version="1">MQSQGAEINKENVKNVCSICGFANGANILLKYTKVIEEAYPPTKGSVKAAGYDLKSAHDVVVPARGKALVDTGLKIELPEGCYGRIAPRSGLAVKNFIDVGAGVVDEDYRGLLKVVLFNHSDNDFEVKSGDRIAQLICERIFYPELEEVKELTDTARGEGGFGSTGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1C8</accession>
    <name>A0A6P7G1C8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U-actitoxin-Avd3k-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114334898</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140837.1">
        <property type="nucleotide sequence ID" value="XM_028285036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1C8"/>
    <dbReference type="FunCoup" id="A0A6P7G1C8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662557.1">
        <property type="protein sequence ID" value="XP_050518514.1"/>
        <property type="gene ID" value="LOC126892824"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G1C8"/>
    <dbReference type="OrthoDB" id="6775666at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027784965" evidence="4">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="5">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028140837.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="11318" checksum="B7423C142726C380" modified="2020-12-02" version="1">MKIALPFFCFYILASSHVYGDVPEIIVTKASEEVLPPGPFTKADCSLGVEQDGLVCQAYIPVYRWSDAEKKCIKDIYGGCRSTKNNFLTEADCVKTATPVCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1X6</accession>
    <name>A0A6P7G1X6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 84-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114335061</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028141017.1">
        <property type="nucleotide sequence ID" value="XM_028285216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1X6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285216.2">
        <property type="protein sequence ID" value="XP_028141017.1"/>
        <property type="gene ID" value="LOC114335061"/>
    </dbReference>
    <dbReference type="GeneID" id="114335061"/>
    <dbReference type="KEGG" id="dvv:114335061"/>
    <dbReference type="InParanoid" id="A0A6P7G1X6"/>
    <dbReference type="OrthoDB" id="5383296at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028141017.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="67130" checksum="A18F9FECF441A436" modified="2020-12-02" version="1">MDKIKIEEQDRPRPFQTSIRMEESNQLPYKNIRLQQESLGLFSSGIGASKSIQDVYVNTSSSSSCSSVKLQDYTESEKRYINPFASNDFYHLLDQPCSSKQADLILKQFEAVSLPVQKVKKIKKRFQCPICKIGLSSFYVRVQHINYHFKYNPVSCFSCGKFFVNKKRYFLHNVIHCVKKRRPRREIPVLSIPEDPEDPEDLPYPFENNLVTNGKVIDDSVIFNKPQFECEVCLEQLTSFDALQQHLKSHPKSFDCDLCPKTFTRKSTLTQHKLTHLSPQFKCEICFKLFKSKSNRNRHLLTHSQIRNSYFKCTMCLQKFSKTISFVNHWFSHQEKLQQQCKRCNKRYIKYYELLNHYKKEHFTIPEEVTFACCPYCEINFTKESLLEHLDTKHEELKECGLKKPFTCQYCPMSFISEQALDNHVSVDRRPVQCNICCIEICNYDSLVKHLQEAHINLKTPFLCVICTREFPDKDTLVSHLLSEQGTDSAEYYKQCEICRWNFFDEQEFNAHWKSLHHLSLPVEEVVEHQEVIEPVVEKTEEAKDEFDIVYEALEIKEDTVEYSGFFDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2W0</accession>
    <name>A0A6P7G2W0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 18">Protein maelstrom homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC114337107</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16 17 18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the maelstrom family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143294.1">
        <property type="nucleotide sequence ID" value="XM_028287493.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143295.1">
        <property type="nucleotide sequence ID" value="XM_028287494.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143296.1">
        <property type="nucleotide sequence ID" value="XM_028287495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2W0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287493.2">
        <property type="protein sequence ID" value="XP_028143294.1"/>
        <property type="gene ID" value="LOC114337107"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287494.2">
        <property type="protein sequence ID" value="XP_028143295.1"/>
        <property type="gene ID" value="LOC114337107"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287495.2">
        <property type="protein sequence ID" value="XP_028143296.1"/>
        <property type="gene ID" value="LOC114337107"/>
    </dbReference>
    <dbReference type="GeneID" id="114337107"/>
    <dbReference type="KEGG" id="dvv:114337107"/>
    <dbReference type="CTD" id="84944"/>
    <dbReference type="OrthoDB" id="24555at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060964">
        <property type="term" value="P:regulation of miRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21992">
        <property type="entry name" value="HMG-box_MAEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024970">
        <property type="entry name" value="Maelstrom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039259">
        <property type="entry name" value="Protein_maelstrom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21358">
        <property type="entry name" value="PROTEIN MAELSTROM HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21358:SF4">
        <property type="entry name" value="PROTEIN MAELSTROM HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13017">
        <property type="entry name" value="Maelstrom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="HMG box" evidence="13">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="409"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028143294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028143295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028143296.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="54586" checksum="8002754AD962C559" modified="2020-12-02" version="1">MPPKSNKSRNAFYYFMEDFKQRQGFACKSMKDVADAAGPHWARMSKAERRPYEERANKEKGGLRYTWDGQCVEDIERRNKAEDNKIAKMKDDIDCTLKFAKENCRLRDEMFFIIHINTFCYHASGDRYYPAEIAISCFSLEDGVLPQNVFHKIIKPGRLPLGYASDAKKQSEDSHQLPIPLTGDDDDNVEEVYTEMKEFILSKTGDTKKFPPLYAKKDIVKMLQHVLDTWCADFDEPPLFKVYYLQYMFQVLKNSVANDNVWPLYSMAETELDKDLYSHTVGICCEFHSVSEACQFCSKSVAVRLAYTICDNCCSFLDIPIEPGRHVPDQAFTASSLSSRASSKASLYTGSSKSSKKQSVREDDKDTVLSFSSASQWESESVVSDSSTATFNNSFPGLKSKWTLSNSQPVETDSMSQMSGQSYASAMGTRRQFSSAMGNRGSQRESSNNSNNGDTSDSNTDYFNSQSFPALGRGRGMARNRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G331</accession>
    <name>A0A6P7G331_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein xylosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peptide O-xylosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114333683</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>UDP-alpha-D-xylose + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
            <dbReference type="EC" id="2.4.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 14 family. XylT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.26" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028139428.1">
        <property type="nucleotide sequence ID" value="XM_028283627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G331"/>
    <dbReference type="FunCoup" id="A0A6P7G331">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283627.2">
        <property type="protein sequence ID" value="XP_028139428.1"/>
        <property type="gene ID" value="LOC114333683"/>
    </dbReference>
    <dbReference type="GeneID" id="114333683"/>
    <dbReference type="KEGG" id="dvv:114333683"/>
    <dbReference type="InParanoid" id="A0A6P7G331"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="UniPathway" id="UPA00755"/>
    <dbReference type="UniPathway" id="UPA00756"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030158">
        <property type="term" value="F:protein xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043538">
        <property type="entry name" value="XYLT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024448">
        <property type="entry name" value="XylT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46025:SF3">
        <property type="entry name" value="XYLOSYLTRANSFERASE OXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12529">
        <property type="entry name" value="Xylo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="21">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028139428.1"/>
        </source>
    </evidence>
    <sequence length="903" mass="104068" checksum="408A80B3500C3A3D" modified="2020-12-02" version="1">MVKTSSKNSKWIRRYRTFFIIGIVILAFQIYLAVKFLSINKSIAEPNDNKWLSVHFDDEQEADVNSANKFKANHDYEVSSVVQTQKTKDKTNHTYSLKYEELDFVPACQISSKEAVSAINRAKTQTCKQFISNITCLSIKNELYPKELKGLCPNGEFVAGKELGCFKDEKNFRLLTGYFGISKKDNSPKYCMRLCLQSGFPYAGVQYSNECFCGVDEPPLTSKVPDSSCNLKCPGDVHATCGGYYNMNVYHTGIKRFIPQTANIETENKTRSTVKIVFLLTLNGRALRQVKRLLKILYHKDHYYYIHIDIRQDYLYRELLPLERILPNVRLTRKRFATIWGGASLLEMLRSCMWELLNMKDWKWDFVLNLSESDFPVKPVQKLSEFLTLNKNRNFVKSHGREVQRFIQKQGLDKTFVECEHRMWRIGDRILPSGIQMDGGSDWIALSKSFVEYVTDPVSDDLITGLLKIFKHTLLPAESFFHTALRNSKFCDTYIDNNLHVTNWKRKLGCKCQYKHIVDWCGCSPNNFRPEDWPRIVNTLSRQLYFARKFEPLVNQAVILQLELWLCGLDTPSRSVENLHGYWQNLYHHRDLEVTKNDALLTISNSVKRHAMKMLNNDTCYLNTLLEVTSYHFNNSYQYTLFKFDVSDTHSVELAVKPLNKNVLSKNSTLMSHLDFLTVATDYDQKEQMSRNFLRIMSPFSEPLLIYSFSRSPGSKIYNLTSIWIGPDGQMYDAVDFSVDSSSLLGNVKAGLKQPILPGVWNVKLIYKNYQLSETKFLITPLEYFNGSPIRPHQVTYLHGGPKDKKDFKNSFGKFLAPDKQRQEMERASLANSLKTDVDLTKWVDELFLEFYAIKKTCESAKSSQVCGVKLGKCEESSWSSLAPDPKSAIGQVNSTTGTFDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDK4</accession>
    <name>A0A6P7GDK4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-SGDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114338180</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144572.1">
        <property type="nucleotide sequence ID" value="XM_028288771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDK4"/>
    <dbReference type="FunCoup" id="A0A6P7GDK4">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288771.2">
        <property type="protein sequence ID" value="XP_028144572.1"/>
        <property type="gene ID" value="LOC114338180"/>
    </dbReference>
    <dbReference type="GeneID" id="114338180"/>
    <dbReference type="KEGG" id="dvv:114338180"/>
    <dbReference type="CTD" id="46260"/>
    <dbReference type="InParanoid" id="A0A6P7GDK4"/>
    <dbReference type="OrthoDB" id="9995605at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028144572.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20846" checksum="0C9565069AC856C1" modified="2020-12-02" version="1">MVILSTLRTLTRLPSSSLRNEASKRLMSDHRVFPMQPSRWQWIKFKDYFHYYVMLGLIPATLAITYANVFIGPSTLSEIPEGYTPKFYEYHRSPVTRFLAKYICKDPQQEYEKYLAYIFMEDEKRKLRKLEKEVKHKMAERNDYQAYYYRPVAAKYHRITREAADYLETIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFX4</accession>
    <name>A0A6P7GFX4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 43-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114336733</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142895.1">
        <property type="nucleotide sequence ID" value="XM_028287094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287094.2">
        <property type="protein sequence ID" value="XP_028142895.1"/>
        <property type="gene ID" value="LOC114336733"/>
    </dbReference>
    <dbReference type="GeneID" id="114336733"/>
    <dbReference type="KEGG" id="dvv:114336733"/>
    <dbReference type="InParanoid" id="A0A6P7GFX4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028142895.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="52469" checksum="DCC3DD97991ACF6D" modified="2020-12-02" version="1">MEFDEFCCVCVQRDLHLESIENVDENEIKYSEKLCLCDNNQEWKREYKICLNCVAQLNLAYNFIQACVKSKELRTSIETAQQKAYPCDQCNKKFLQKSSLLTHIIIIHNEQKAEESEQPFNSQDNTIETNEDKVGECVTNEEKTEGNNYSSEEEEEQPKPVLKKKYNKLKVPLTCEYCGKNFNRRQHYTAHIRAKHTFEKPYKCDLCDAKFTNSHNLLVHKRNHNNEKPFVCSYCGKCFVCSGDLYHHSKIHLNKREYKCNLCDKSFNTTSILRTHKICMHVEPKDWKYICKYCEKRFPINSSLVTHMKRHEGIKEVDCHICDKKFFDKSELSKHFRSHNNERPFKCNLCQDKEYKNHYGLKKHLKIIHNIGSINIPKPEKKFACPLCSKSFAFNNKLQKHLCTHTGIKPFKCLHCDKRFIENYYMKMHLKKKHNIDSSTAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIX8</accession>
    <name>A0A6P7GIX8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hypertrehalosaemic prohormone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114343015</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AKH/HRTH/RPCH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149629.1">
        <property type="nucleotide sequence ID" value="XM_028293828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIX8"/>
    <dbReference type="FunCoup" id="A0A6P7GIX8">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641312.1">
        <property type="protein sequence ID" value="XP_050497269.1"/>
        <property type="gene ID" value="LOC126878538"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIX8"/>
    <dbReference type="OrthoDB" id="6159864at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002047">
        <property type="entry name" value="Adipokinetic_hormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010475">
        <property type="entry name" value="AKH/RPCH_hormone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06377">
        <property type="entry name" value="Adipokin_hormo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00256">
        <property type="entry name" value="AKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="7" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027848012" evidence="9">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028149629.1"/>
        </source>
    </evidence>
    <sequence length="70" mass="7908" checksum="628CA8AC31281CF3" modified="2020-12-02" version="1">MYKVIIIVIVAVIAYCTAQVNFSPNWGKRAINPGEENGNNCKESVDTLMLIYKIIQNEAQKLVECEKFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJZ6</accession>
    <name>A0A6P7GJZ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC114339797 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114339797</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146282.1">
        <property type="nucleotide sequence ID" value="XM_028290481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJZ6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028290481.2">
        <property type="protein sequence ID" value="XP_028146282.1"/>
        <property type="gene ID" value="LOC114339797"/>
    </dbReference>
    <dbReference type="GeneID" id="114339797"/>
    <dbReference type="KEGG" id="dvv:114339797"/>
    <dbReference type="InParanoid" id="A0A6P7GJZ6"/>
    <dbReference type="OrthoDB" id="10009200at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16571">
        <property type="entry name" value="RING-HC_SIAHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028146282.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58113" checksum="70542E43C8BD8C29" modified="2020-12-02" version="1">MLTNADKNHYHRSVRLIQIEKTSAQCGFHLTRSKWDPYPWVSSVDNDSAASSSGVKTGDCVIEVNGEDILGKRISEIAEIVKSKPEQVSLLLWNADIDAHCTNENLCCGPLPRQLQKLSSCLTTILAFLECPVCLDTISCPTYQCDNGHLICIKCRSKTERCPVCRIRLHRGRSLMADHVFTAITDIFAPYEETKEARVANIQKIFKRKDKNKAIPDITVTESYTNKLISKIAGKSSSADNLSTTSKYLTIDDAVADRNSQLKVKSLSVNEIFRSHTPSLSRNGSRLDKTYLSIENTRKTDERPLSFHGSFESLGRQTDFISPLCSSFNSLDVAVTGGNPITSYYCPFLNSCSSVLKATSLFEHFVKNHSETGPLVQYFADNLNLYLRDFHDNQEYCYTLLTLGQTFFLKVKLFNEPELKRHILFVLSASNILIWVWHLGCEKSSRNYEVQIEIRNMLTQDVLLGARSSAFSLNSVSPQEIEEYKKGVYLSYKSMESLGFHSSQLLVKMSSFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMA4</accession>
    <name>A0A6P7GMA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Plexin-B isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114338513</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144915.1">
        <property type="nucleotide sequence ID" value="XM_028289114.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497464.1">
        <property type="nucleotide sequence ID" value="XM_050641507.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497465.1">
        <property type="nucleotide sequence ID" value="XM_050641508.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641507.1">
        <property type="protein sequence ID" value="XP_050497464.1"/>
        <property type="gene ID" value="LOC114338513"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641508.1">
        <property type="protein sequence ID" value="XP_050497465.1"/>
        <property type="gene ID" value="LOC114338513"/>
    </dbReference>
    <dbReference type="GeneID" id="114338513"/>
    <dbReference type="KEGG" id="dvv:114338513"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097374">
        <property type="term" value="P:sensory neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12205">
        <property type="entry name" value="RasGAP_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000027">
        <property type="entry name" value="Plexin A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000005">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000071">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000213">
        <property type="entry name" value="Plexin A4, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000203">
        <property type="entry name" value="Plexin B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000728">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027566105" evidence="17">
        <location>
            <begin position="35"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1256"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="18">
        <location>
            <begin position="20"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028144915.1"/>
        </source>
    </evidence>
    <sequence length="1906" mass="213047" checksum="49F0F530111B2EE0" modified="2020-12-02" version="1">MLIKTVHAGTVGSTVAGIWLLLLALAGLWGPASAGILLAQYPGPDDPSERFWHMAIDQKTQRVFVGGTNRILQLDGNLRLEQVVTTGPKNDSPSCHAIGCNDPSIPLSLMDNYNKILLVEPESRTLISCGSLSQGACSKYKLSNISAESQFIPRSIAANDANASTYAYIGPKKYNHWGRSNILYVGTTFTNNGDFRHDVPAIASRDLETLEIAELTFSKQSLLSIDVKYRDHFIVQYVYGFNASEYAYFVIVQKQSHLPGLEEQGYVSRLSRTCINDPNYDSYTEVTLLCVDQDTKYNLVQDAKITFAKEELASALGITVGSPVLVAVFRPSVGITNEPQHHSALCLYPLRDIEGKFIENIHMCFNGSVKDRNMGYVSGPILDGKCPSSGSAGNIPNFCEVGLKISGFTPLVATASLVFPNISLSAVTTGSTGKHVLAFLGTTDGRIKKVLLSGPEPPEYEEVFVDDGNPILPDTTLSPTGDFLYVLSTARVSKINVEHCSTYTNCSSCLESKDPYCGWCSLEKRCTVRSACQKASHSAPRWVSLGTGQQCIDFEQVFPERIPINQMTNVRLTIRTLPALPPGAKYKCVFGNADPIDAEVTENGLSCFTPEISRRPRIPLEMDHVLVPLSVRSSETNKDFVSRNFAYYDCGRHTTCGECVKSKWACNWCVYENKCTHNISVCQRSIISGENNPKHLPKHGFVFCPQFKRKNEAILLPNNVLKKIVFEVINLPNPTSVHTGFQCKIVIEGATMLVPATVESKHIVCDKTTYSYEANEGEYEASVEVVWNRDHHVDSMNVTLYKCDILGSYREHADCSLCVTRNSNYSCTWCGNSCQYSESCQHTPHIECPRPRIDMIKPLSGPIEGGTLVTIEGSNLGLKKEDVQGKIKIGAIPCVLVNYEVSVRIQCITGPSRIEITAPIRVGNEAGYTKSSVEFSYKDIRLSGIFPSIGPQSGGTPLAITGQYLNVGSEITAYLDDYVCRVNITQASSGRLTCITPRAHRPTNVVRLTLSIDGANRTLEGNPFNYTQDPTIMEIKPLNSFVSGGKMIFVHGTNLDSIQKPEMEVYSFDEPNTPINRTVCTVLSSTQMECPSPPVNRQFSIFSRNSRIKNKDPKLNLRIGFLMDNVQSVRDLEKHFVNLRSQLLYVEDPNVRPFPNQIKLYQGDRLVIEGENLNAASEESDVVVTIGTKSCNVTGLAMIQLVCVPPEHQPPGTDENGFKTENNLPLVVVRVGRTLRFPIGYLQYDIFKSFAFPLEAIIMIAVGTILFVLFFVAVLFVYRRKSTQAEREYKRIQIQMDTLESNVRSECKLAFAELQTDMTDLTADLENSGIPTLDHTSYIMKVFFPGVSDHPILNAPKVRLNGPRTNYDTAMLQFEQLINNKHFILTFIDILESQKTFNIRNKVNVASLLMVVLMGKMEYATDILKSLLLRLIDKSVNTKHPQLMLRRTESVVEKMLTNWMALCMYHYLKEYAGSSLFLLFKAIKHQIEKGLVDAITHDARYSLSEERLLRENVDYSVVTLHIVQDDLDEKIQCKVLDCDTISQVKSKILDALFKNTPFSLRPSIYEVDLEWRHGRGGHLTLQDEDLTTKTICGWKKLNTLAHYGVKESAVMSLISRQNDSFNNCKQPCHNCVTGMYLNNSQSPIITTNGDIEGGNNPRIYHLVKPIDDHQFPNNKMGERTHKAIPEIFLTRLLSTKGTIQKFVDDFFMTILTVNEALPPAVKWLFDLLDEAARKHGIQDPEVVHAWKSNSLPLRFWVNFIKNPDFIFDINKTSTLDSCLSVIAQTFMDSCSTTEHRLGKDSPSNKLLFAKDIPRYREMVSQFYSDVAMLPIITDQEMGSAMQQLSSQQAEEFDTVAALKELYIYVTKYREPILEGLSTDLNCRRLHLAQKLESVAYTLGGDENSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQB3</accession>
    <name>A0A6P7GQB3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114345163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114345163</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151784.1">
        <property type="nucleotide sequence ID" value="XM_028295983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQB3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050661202.1">
        <property type="protein sequence ID" value="XP_050517159.1"/>
        <property type="gene ID" value="LOC126891870"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQB3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027981735" evidence="7">
        <location>
            <begin position="29"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028151784.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35730" checksum="5A2868AA9E343606" modified="2020-12-02" version="1">MTYKLKVNFFAALFWAAVFFANNQPSCAVLSKDLKAILPSGDQMPLIGFGTSKILGTELVKNTLDDALAAGYRLFDTAAVYGNEEDIGKALKELLPKHNLTRKDIWITSKLAARAETLGKNAYAALEKSVKTINCDYLDLYLIHFPGIPSPEKKNYSALRDESWQQLVKGVKNGLTRNIGVSNYNVHHLTELVNNDHGVKVAVDQVEWNPRFHQDDLINFCKQNGILLQAYFSIGGTGNTDLINNVEVKKIAEKLGKHPAQVLLRWAVQQNVAVIPKSLSRKHMDSNLDLNFEIPQADMEVLNSFPQKLKNPGWNPDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTG8</accession>
    <name>A0A6P7GTG8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proton-coupled amino acid transporter-like protein CG1139 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114340562</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147120.1">
        <property type="nucleotide sequence ID" value="XM_028291319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTG8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291319.2">
        <property type="protein sequence ID" value="XP_028147120.1"/>
        <property type="gene ID" value="LOC114340562"/>
    </dbReference>
    <dbReference type="GeneID" id="114340562"/>
    <dbReference type="KEGG" id="dvv:114340562"/>
    <dbReference type="InParanoid" id="A0A6P7GTG8"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF340">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="33"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028147120.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="49770" checksum="F9CDAB22A00D4B3B" modified="2020-12-02" version="1">MADASSKAKKDDPDEEYDPYLHRNLPNPNKSIETLGHLVKGIIGTGILALPEGFKLAGMLVGIISTILIGLLSTYCLRILVQSQYELCKKKRVGLLTYPESMQYACEVGPKCFRRFSPYAGGLTNFFLVTFQIGTCCVYVVFVAVNIKFVGDEYTDPKIALTYYILMFFVPFLCIIMVRNLKIFAPFSIAANIITLLTIGVCGYYIFQDLPPFSDRPYAGKFSNYFLYFGTSLFSLQSITVVTSAENNMENPRQFLTPFGVLNVGMAIVVVIYSFFAAAGYWKYGDEIKSSITLNFPSSDAIAQTIRCLYSAAIFISYGLQGIPAVYIIYHDYVLPRIGEDASNKKKLTWDIGLRIGLVVTSIVLATTVPLLGHIISLVGVFCLSALGITFPAIIELSAYWPDRLGPGKFCLWKDIVIVLIGLFGLIVGTYSCVYNIVQELIDLYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H2K9</accession>
    <name>A0A6P7H2K9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein DDB_G0290503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114349495</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155684.1">
        <property type="nucleotide sequence ID" value="XM_028299883.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299883.2">
        <property type="protein sequence ID" value="XP_028155684.1"/>
        <property type="gene ID" value="LOC114349495"/>
    </dbReference>
    <dbReference type="GeneID" id="114349495"/>
    <dbReference type="KEGG" id="dvv:114349495"/>
    <dbReference type="InParanoid" id="A0A6P7H2K9"/>
    <dbReference type="OrthoDB" id="10384911at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="795"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="863"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028155684.1"/>
        </source>
    </evidence>
    <sequence length="1778" mass="207731" checksum="2D1C2E6A3F13687B" modified="2020-12-02" version="1">MQSISGKKQYLSLDTQEKNYINHAIHSNKENHFPVLNRADFLREIDEKQQHIYKIIYKAYQEIDKYKTHFIQDVPNQQKIKDNTSITSNNILKKQTDNKVRIENFIAQKYLTLNPRNIEHNEILETNKNGENFNHSTHQKSSNQSFDDVISTIEMNKQVVEKFGSIISDIRNSRETNNKISKNINWTDDIEDIEREQENNKTISGFKGFMEEILSYLVYMYHDLIGEYENCLSEVKKDSNSDNFREKYKQCTKIPERKFLQKLKITSDIIKQTFLAVTEKLVVDNVEAILKNNQRLDEHDNVLQIINELSDACEYIRKTPGIEMMFSEAQTETEYDETIGDDISDMNKLQLSEINNMFNDKYMEATENKVKHKAKILNYAATIEESDLVLNVEEINKPNQLQDRNGRDEYLNVELTSKEELLQNKQETDLIVKNESTWNESIGEEPMTMFTTTEQDNETMEATSYIISALAATEEELNNITSEGESVTNTLSHTTTQDFIMTIDTQPKRLALKTSNQQDLKKLKPQQENLKTEHKPFKPNIESTNLNETIKNLECESQKKIEKNIKCKTKLSKDEIVQQLDLIYESLKTDSQCIREQGNEECLQPITFESQIKLEKSKLIIFEQLKFLYDNLYIIYSPLYKRITDTINTEDSLRNKLFNEEHNRKYLIENKQDNIDQKNFGNQNFENQTNQQKTYMKGITNMKIINPSHKVNNVTNGVMQAQAVYQVLLKEYNDLKTKKITSPKIINIQEVPTDNKNKCADNNSTEISRNAILEEENHAKIKHDVNDIPTGSNWNNTKKQIEDELKSQLNQLKSKYQNQLHELKIQWEKSVNYLYNCNYKIEQEIINIDKKIDQLPSTDGKHVAELKASYQETKKEYKTYISKKQIELQQEVTNFEENQKQIEEKIKLLEHKINSLIQDFQQKHVQNNDPNVSPEENNIKDEKWQKLSDHEENNYQYEENSKEIDLVVQNESKSNEITNEEPMTMLTTTKEDNKVVNYEVRNSKNKKSGETERQNQVQYNTSKYLKTSNTVENSNRNRNKPLIKNNDKKVTEEEIKHDDKSNFKEKINRTYKIAKTFDGETKFKEKTNQNNKHVLKETTKTLVKTNKTLDKQSKPSRIPEAKKSLKPVSKDVDAKDLSTKPISSSKNQRAVTPSNLAQRKNISETKNNLDNKEPEKNKKLNSYIPREKSPLLGGLKQQVMKSKLYVPTKKLENNIKKRNCDRIAQNGDSEALERGIIIENNTSVNDKMSTNDKDNTEKDIDKDTEKDILIEMIKSQLQHLQDTLKMVESVNSIKIRIKNTESVKYFQNIEKEIAIVGKNLEFGEAKAGDDKKYYKNGIVEDSSKVSISSCNVEEIATAKAGRYLQRNLDQILKEFRDIETEKYIRNEISKKQYLNDDVSVDNDISRYIQDSITTRDMPKSTNCDTLVQNYRGHINDLIFDLQEDELLEKKCITPANSVNYIIPEYQLQDDIFTGSGHFVPGIPKMRQYIFGIDSIGPIGIQKDGRVTSKHEQLSNIFRTTPLDKFSQYYSDHSLYTNLKRSIGSIECVDKTIKNAEKQLQRLDEKYKIIISSNQEDNVPKKLDFCSKHLKIEKTNDILESAEKQLERLQKYNFFDEAIHHKDKCNIYITDENSKILSHENVTDIHYPKEKESFEVEDIFHYMRKIPESLKENGQFCKEEELRNVETVKSKTEIVSSLPERQTKSNRNKVKDWGDVVSNSRQSNLKRVRLPNQKLWEGKSSFDTIINFRLEKVNLSNKFKSRLDLDDTEKKCLYDENFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H8P0</accession>
    <name>A0A6P7H8P0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microfibril-associated glycoprotein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114348623</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154957.1">
        <property type="nucleotide sequence ID" value="XM_028299156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H8P0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028299156.2">
        <property type="protein sequence ID" value="XP_028154957.1"/>
        <property type="gene ID" value="LOC114348623"/>
    </dbReference>
    <dbReference type="GeneID" id="114348623"/>
    <dbReference type="InParanoid" id="A0A6P7H8P0"/>
    <dbReference type="OrthoDB" id="6350391at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027940107" evidence="1">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028154957.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34044" checksum="BD2D18D97F64D3B6" modified="2020-12-02" version="1">MYSLVIVITVLVLCSNLKIALSETQELLELTPESRPAIRRRWYPQPEEITITYRPNALDGCRNLVGTSKPSLCSVDSSTPYYYPRSCSDILQSGGNRSGIYVIKPRGSKEPFEVLCDMEIQGGGWTTVQRRFNGREDFYQPWRAYKFGFGTLNGEFWLGLHNIYQMTGSEQYELLIELTDKEGITGYARYASFAIAGEKDGYNLTKLGAYSGNVGDALSGQLNAKFSTLDVDLDGQAGDCAKTFEGGWWYKDNICYVCCLNGKVPTVIFTDQQKWNGINWDGFRGKEYNLSGSRMLIRPVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ID03</accession>
    <name>A0ABM5ID03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130140.2">
        <property type="nucleotide sequence ID" value="XM_028274339.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274339.2">
        <property type="protein sequence ID" value="XP_028130140.2"/>
        <property type="gene ID" value="LOC114326108"/>
    </dbReference>
    <dbReference type="GeneID" id="114326108"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047277469" description="Spaetzle domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="97"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130140.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="197" mass="22401" checksum="B422C4386C7AE8A3" modified="2025-10-08" version="1">MYLNITTFCITLSFLLVLVISTKTQKPAPLTKRRFIPKKTACDLNQLCTNSTAYPKLAIKRLLKRNKKQFGYLAGSVIAPAFDFTSDLLRAPEVEENMCRTKKISMTPKVAFDIKKNRKFIVNVEDFQQIITYETCIDLGESCFGNSAIPNDFETLCKQAYTVVRLLSVTHTGKLEYSYFPVPSTCVCSYRKLNDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ID12</accession>
    <name>A0ABM5ID12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130159.2">
        <property type="nucleotide sequence ID" value="XM_028274358.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274358.2">
        <property type="protein sequence ID" value="XP_028130159.2"/>
        <property type="gene ID" value="LOC114326121"/>
    </dbReference>
    <dbReference type="GeneID" id="114326121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130159.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="210" mass="24949" checksum="04687A80BAC9EA45" modified="2025-10-08" version="1">MALRKILCNSVNFQKLFQPVVIQCNHIHSSSTNHAWKNQERNTKKWLKYNDKVYPPQQPDEEPRKAFVCHQRTNIKYSPWKMWYIACLIRGMPVDEAIKQLKFVVKKGAKDVREVLEEAKELAVKEHNVEFASNLWVAESFVGKGAVIKGMRRHARQRFGIVEYVHCHYFVRLEEGQPPEHYYLSHPKEPHEQLEDWLAQMRRRKITNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIF0</accession>
    <name>A0ABM5IIF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133543.2">
        <property type="nucleotide sequence ID" value="XM_028277742.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277742.2">
        <property type="protein sequence ID" value="XP_028133543.2"/>
        <property type="gene ID" value="LOC114328785"/>
    </dbReference>
    <dbReference type="GeneID" id="114328785"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046372546" description="PAX-interacting protein 1-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133543.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="78477" checksum="2E8C35419B1FE21D" modified="2025-10-08" version="1">MKVLVFFALVACCCAVSTLSVGVLVDDDGGINLLNTKYEINIRRSLSNPKRLTVTLKQGSTSKIVYDLDEPITNKNVDIRNILDTKYIKNLGEVYTQMDVLDGIFSQYDVVDSMTYGKIMKMIKLLVQNDVLHPKVLSVLSMLDNQMVEEPMMTMYDTKNVMKKDLKPEVMTKDVVIPLKDGIEVMHEVSGVVPVEEAENELRRMQMHMNGMEVQQYWNMNQNVMETMTPMQRLLMRLQQVRQNQYQGNMMEEQYYPEYMLSQRYMNPEYYQQMSYQPRMEQMYQQNQMSPLARFMLNIRQPQMQEQQMSMMDQMVRDQMYPQQYQQYMNRVPLQMMMNSEMMDRRMMNMQSMMDNNMMSQNMINQRMMENNMMPQHMMNQKMMQPDMMMNNEMMNEKMMMPQHMMNQKMMQPDMMMNNEMMNEKMMMPQHMMNQKMMQPDMMMNNEMMNEKMMMPMMMSKRMLGQQMMNQKMMAPNMRMRREMMSEHEVPQMMNQKLMQPDMMMNEKMMEPEMMNQQMMVPNMTMRRQMMTEQGVPQTMNEKMVALKMMINNNIMKEKMMKREMMNKKMLEDQMINQQLMMTRKMMAQKQVPLMMKEIDQQMMNEKMMNKEMMNQRMMSDKMTNMEMMKPMLMNERMMYQTRMNTMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIT1</accession>
    <name>A0ABM5IIT1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133792.2">
        <property type="nucleotide sequence ID" value="XM_028277991.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277991.2">
        <property type="protein sequence ID" value="XP_028133792.2"/>
        <property type="gene ID" value="LOC114328989"/>
    </dbReference>
    <dbReference type="GeneID" id="114328989"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133792.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="248" mass="26672" checksum="9151DF01F7469D5C" modified="2025-10-08" version="1">MSLAGRLAFVTGAGSGIGRATCKLFSREGASVVVADKVPKTVEETLNIINQIGQNQHLGVELDVSSSDSVGNALKKTLEKYSKPPTVIVNCAGITRDNFLLKMSEKDFEEVLDINLKGTFLVMKAFANSIVEHGLKNASIVNISSIVGKYGNIGQANYTASKAGVELLSKTASKEFGQFGIRVNTIFPGMIKTRMIETVPDKVQDRFRAMIPMSRFGEPEEIAEVITFLATDKSSYVTGASIHVTGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR00</accession>
    <name>A0ABM5IR00_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="4726" mass="544782" checksum="119D8CB348841D6E" modified="2025-10-08" version="1">[encoded data, 4726 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR01</accession>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
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            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR20</accession>
    <name>A0ABM5IR20_DIAVI</name>
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        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="XP_028139251.2"/>
        <property type="gene ID" value="LOC114333560"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="541" mass="63082" checksum="F0C5F3AD8F7E9520" modified="2025-10-08" version="1">MEFNFENIVQQLKDEYQNTKRPSTIKLKQETQVGDSGEDTKKDQKYLEQEFLELEIKLDQILSNISKDTLNYCKILSIISSILYEKSKVSLNMNALTTSKAYLEKSLNIIKDLSQDPQIRFIYLKVVNYLSYVVSRMGDFEKARTLLEEVVKEELKFDTLVYSTEDLFRSTNSDQALAKAKLRKLKINNLQMLGWVYGKLGLNNLYAETIHESLQEELDINDGDPINWATRCYRLASLFIVQDKWINAVYHLRAAQTVLDPLETSLLPNIALFKAQADLARTWVQYGLQLFSRSRRSVMEKVWEDAWKLCRQNESSDANKFKFTGLEIHPPNVPVKEITNIQEARELFTYTHKWLKRARSFYNLRDYPLQYVNVIQELNELYRYLAFYEKDIDSQYEVHKKRHETLEMLSSLLREVRPTGYNTVSLEIVKEIIDVQLEMMQINLKRVFNPNEDTNYSQEEIKKKIEIFNSVNDKMGNLCKDVNNSSPKFVSDIDGLDHLLPSNILVKSDVDTEPDLKKESKTTSEQPARAAELKSEGTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISF5</accession>
    <name>A0ABM5ISF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140542.2">
        <property type="nucleotide sequence ID" value="XM_028284741.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284741.2">
        <property type="protein sequence ID" value="XP_028140542.2"/>
        <property type="gene ID" value="LOC114334651"/>
    </dbReference>
    <dbReference type="GeneID" id="114334651"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037695">
        <property type="entry name" value="IQUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057887">
        <property type="entry name" value="IQUB_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21074:SF0">
        <property type="entry name" value="IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25805">
        <property type="entry name" value="IQUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140542.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="725" mass="85941" checksum="F0B2020EE545EA6A" modified="2025-10-08" version="1">MTCDQCMCKCGPKCDCDCVCKEKSTVIWMKDADADLEWPSFSKMYTETQIIIKFTISNSKGFTQTYTSQQTVLEILDNLERIFGIPKEHLQLVYRESPLTDEDKLLRDIDAEQPKILELNLSTDDPSIWIIDIEKVYKDIVVPDIITVTVEHGQQSWQVVVEVENKAIQKPELGGYMNSRTGVHYLHGYTQTGPPTPYFPPSMKYHRDTQTYSTRNRKVQMDYANATQMTNTQIYIPSVTDKILTAGAYETAEEREKRLDVEGKVRTIQRYFRAWKMSQALKELSREYHKRLQLELEADARERVEDEERRRHDLVSKVFPLTMSDFAMLYAMVNKWKKSEIARITSLHCGASKIAELYLLLEKEIEMLRAIEKLKNKVEKDLEYKRIQDFFKKIGDPIDWYSTYKSLHIFMDTLETQKGRQYFELYQKLTKNDLSVRQKLNVYMEVKQYIQDHQCHESELLNDLIDRVCQLLARGVSEKQLKGLEKRIEAGVLHHFKLIECNENVTRHLLNKEELRMEKNLQYCPRCQKFKTIEDFKLTARTEKLRICRTCKWLDKADEPWVDLSPYRFILKQIRNYERLHHAVTSVVFILQDIDIHHITVQIWHGHSALSECNDIYQLRLVRWDMHKEWAPWNCILLTAEEAKAHLKVTSLDQVYEEEFINHVTNKHLLARRHFPQLKTFDRFFTKMADGDIRLDENSEYYNKPKMECLEMEGYCCNKFTCDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISV5</accession>
    <name>A0ABM5ISV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140908.2">
        <property type="nucleotide sequence ID" value="XM_028285107.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285107.2">
        <property type="protein sequence ID" value="XP_028140908.2"/>
        <property type="gene ID" value="LOC114334970"/>
    </dbReference>
    <dbReference type="GeneID" id="114334970"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140908.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="289" mass="33492" checksum="D04BCED9785671E2" modified="2025-10-08" version="1">MSSAKKTQNFRRESYVPRKMGKSHRKVLAVSKEYNISRHYETQHKTKYDKYQGEARNILEKELKAKLNKQKSLFTKPTAVQSSSLAASYEGKNKTVSQLVGQIETFRKKLDLFENCMKINDLTHFPACFEINQEETMVDFSRFAKVLTEIKREFNERISKFDALKPDLELFNNPMGVNIQNQSAEYQLELFELQSDSIFQAKKNEDISTFGKLVSNRFPKLRNFAVKLYSMFGSTYICESTFSALKHIKSKTRNRMENDSLEACISLTTSIDIDVQKLVEDKPLPQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ITG4</accession>
    <name>A0ABM5ITG4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028141394.2">
        <property type="nucleotide sequence ID" value="XM_028285593.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285593.2">
        <property type="protein sequence ID" value="XP_028141394.2"/>
        <property type="gene ID" value="LOC114335365"/>
    </dbReference>
    <dbReference type="GeneID" id="114335365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044988442" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141394.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="574" mass="65766" checksum="69FDF01C53107CB9" modified="2025-10-08" version="1">MERFVLCFIIFPIIFIGGSDSCKEKPIIKLSDGSIQGIRETSNSGKPYYAFREIPYAEPPIGELRFSEPISPKKWKGVKETVNITKICLTQLPPLIPYELQYYTDDKRENEDCLYLNVFTPQLPYKENITGFPVYVYIYGGFFIYGNPTGYDFQYLVDEGVVVVSFNYRMNSLGFLSTEDNVFPANLGLKDQLMVLKWVNKNIELFGGDPTKVTLGGHSAGAILTGYHLLSKKSKGLFRSAIVQSGTPLMSFGYIANPRKFAFMLGEKLSRDFHSSMNTSQDLLKLLRSLPGKEVAQVNLGNIEGFDYKLVEFRSTWAPTKEDPNYEHAFLTDDTMHENFKKGHFNQVPVMIGITDEEFKDYGNLTRAGLLVDSNYSLLIDPVVPLKKENILPMVNEIKNIYCNTNRFAQNATGMAKILSDILYGIPIMTNAKLMSKYTDVYFYQFGYLGPINGINFWKQFSTYGLKGLGNCAHGDELPLLYDFNSIRPVEPPNSLDILVRKRLVKLWVNFIKYGNPTPEEDPLLLNITWQKMTPTANNYFNIDAKVDLKKNMTYFNEWLEKVDKYFENPRRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IU28</accession>
    <name>A0ABM5IU28_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141925.2">
        <property type="nucleotide sequence ID" value="XM_028286124.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286124.2">
        <property type="protein sequence ID" value="XP_028141925.2"/>
        <property type="gene ID" value="LOC114335835"/>
    </dbReference>
    <dbReference type="GeneID" id="114335835"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141925.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="657" mass="74782" checksum="FB95F533862666F5" modified="2025-10-08" version="1">MADQEKGPDIVSDHDKEVAQNALAEFKKKNYTACFQLINKLEDRSGDLKVVQNRAIVEFLKNDLKKTEIVQKNLTQICNQFQIKAEKLDYIDYCIILYNLTVLLFHQKRYTDAQRIMDKVYKFIEPMDENLAKQVSLLAIELQLSIRKPDKALKLISYLENNLIYGGSLPLKGLDKNGKDRKITLPPPKPLSEEFERKLLKYKVRCYVMNHSMKTAIKEIPVLLKDKSNIDAMFLSANIEYIKGNYEGAVQILTSIPNGCLNYHDCGESSTIMFYNNMGAIHYAMGKPNLACHYFQMALKEDIKLMQQYQKKDDSDKPLYTLGGSKYHELMYNLGIALLHSKRPTQAFDCLIIAVRRYHRNSRLWMRLAECCIMVHKETNEVDFGEQKNLIAELIGSAEKQKVVLATNFSNDKKYSTESQSYAVPVPSLEFASLCLRNAYLLIPSDTETPPVPLFLVTGIPPPAPPPSPGPSPSCPLNPDGIAVLRNGILIASAYVSLCLGDYILALEYSKELLDQPRISEVHKLLAHLYAAESLVLLDKISEALEHLKPENIKDISFDLPQEESEDDIVKNNPPPKWFPDNIQTAYSVMQYNIAVAKTMRGQLDQAGILLRQIWQMKKTCKVPAHIVMLYIYIELQLGHMDAAKTLIRQYQHRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUA9</accession>
    <name>A0ABM5IUA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028142194.2">
        <property type="nucleotide sequence ID" value="XM_028286393.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286393.2">
        <property type="protein sequence ID" value="XP_028142194.2"/>
        <property type="gene ID" value="LOC114336070"/>
    </dbReference>
    <dbReference type="GeneID" id="114336070"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="155"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="14">
        <location>
            <begin position="340"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="431" mass="50051" checksum="C2A530D8F6D9B4DD" modified="2025-10-08" version="1">MLNISSISLIKQTHFKLFKRLLSKAQLKTNDLILLNQNYLKDEYTNITDKVSGYIGRNIYLQPSNPLNLVRQRLVNYFYKKYVNRRGNPIFSIHDNLPPIVNVTQNFDSLLIPKDHPSRNKSDCYYINKKFLLRAHMTAHQSELIQSGLNNFLIIGDVYRRDEIDRTHYPVFHQVDAVRLRSRNQIFSDDNLNIFEEGTNTAFTGNQEKQACHSLEAVKVVEFELKDTLVGLAKALFKENTKYRWVDTTFPFTQPSWELEVFHNDEWIEVLGCGIMQQAILNNAGVHDKIGWAFGLGLERIAMCLYQIPDIRLFWSSDSGFLNQFKNKNVNDDIIYTPISQYPQCKNDLSFWLPPGEFSANDFYDLARNIGGDLIEQIELIDEFKHPKTGKVSHCYRITYRHMEKTLTQEEVSVIHKSIADAVKELGATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGZ2</accession>
    <name>A0ABM5JGZ2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497209.1">
        <property type="nucleotide sequence ID" value="XM_050641252.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641252.1">
        <property type="protein sequence ID" value="XP_050497209.1"/>
        <property type="gene ID" value="LOC114343814"/>
    </dbReference>
    <dbReference type="GeneID" id="114343814"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="192" mass="22552" checksum="426F3E0C9793E53B" modified="2025-10-08" version="1">MELRFYIILFIVILAWGSTYLMKYMSIDLGTDDIDDCGREGTIEEFLRSTATAKPTPRFCYNYVDDDGYVITLCNENKKEAEKKDTKPYSNNTSNNTSADKIDDDDDDDIEVSDVLNSTMKEKLRRYEEEKIFKAAMKQHYDQIRVYVISWYVVLTFAVIYLVSELTVFIVTVILTVYAVYEAWLEDMFRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGZ8</accession>
    <name>A0ABM5JGZ8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497208.1">
        <property type="nucleotide sequence ID" value="XM_050641251.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641251.1">
        <property type="protein sequence ID" value="XP_050497208.1"/>
        <property type="gene ID" value="LOC126878498"/>
    </dbReference>
    <dbReference type="GeneID" id="126878498"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="242" mass="27841" checksum="B26CD54A4B6C1800" modified="2025-10-08" version="1">MTRVRSRSPPRSKALSPPRYADSKESLLLQHPEESSDDHSSDQEDGKDGFTIQNRRTRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTRANEEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKPEKKNPEKTDKKPPLKDEPKHQKEKMKLNEFHCDVMTLIMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM15</accession>
    <name>A0ABM5JM15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050498984.1">
        <property type="nucleotide sequence ID" value="XM_050643027.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643027.1">
        <property type="protein sequence ID" value="XP_050498984.1"/>
        <property type="gene ID" value="LOC126879777"/>
    </dbReference>
    <dbReference type="GeneID" id="126879777"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="398" mass="46729" checksum="B8C6F93094E54583" modified="2025-10-08" version="1">MKKYHRLLLIIVSAISLILFLIYRHEYNRLHYVLEVFNFFGQPCNFSDLQTSDYTLKQYDWGPQPMWQEIDNGYVYSAFLTGKIEVKAIALPLDAKKVPRNCYLWFEEKKKPLTGKFTFSKMLNTNLSSLTPYFFYCTAPTIDNSPYAVSFTYKPKKESEMKKILLVDIQITNHKTPNINTTICVSPTTFSKKKIVEFFSFHRLVGVESFIFYTKDIPYRLSKLLMNLSKRLDAHVAFLPWNFPKNDIDVAQSIIEYDCLFRTYGRSRFIITLNLNEYLVPTTSYTIKELLNDLENQVHRLSLPVQKFCINNVSNNKPLALQNYDVIRDINHNDVRFIYKNVEDNNFNTNTVDKTRASVHKYVKCGVYSQTTTDYSMQKFSIDFTRSTLVQLLIHNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMD0</accession>
    <name>A0ABM5JMD0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD and tetratricopeptide repeats protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499085.1">
        <property type="nucleotide sequence ID" value="XM_050643128.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643128.1">
        <property type="protein sequence ID" value="XP_050499085.1"/>
        <property type="gene ID" value="LOC114328534"/>
    </dbReference>
    <dbReference type="GeneID" id="114328534"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72166" checksum="6426854E618BACA6" modified="2025-10-08" version="1">MEGRLRKWRSKRDFLKLLQSRETNAETSKFFKQHSQFTDSLIKRLGLEFELLGHQGCVNCLEWTPNGERLASGSDDTNIILWDPFRHKHLQLIPTQHIGNIFSVKFLGGSSTDIATASGDGRVLVQSIPTAVAKGHPLLECSCHVNRVKRLATSPIEPSLFWSAAEDGLIIQYDLREQHECSSSQRKVLIDLSSNYGELKCVAINPMKPHYLAVGANDCYVRLYDRRMLKPYIKEGHFFLPMDMNANKPSEIEPVELNCAQYYAPGHLAVENAKMINYKLAVTNISFNSAGSEMLANMGGEHIYLFNVNNSRHISDMQVPPIFNKKDQPVCKHCRKTGGNGYINGVKLDQCPEENCICFYLERANQCQKRKWMGDTYNAARDFLHVIQNWPNHTQAYIGLIECLIELKWGKEAQRWLDYFLNLPINTNHEKAVNLPSDVLNSVLSNQEKADRENEKTEQSIAERTFRKVGEVEQKRRLESLDFELRFLGHCNTTTDIKEASFLGEDGNYVCAGSDEGIIFVWERKKSKIVTALFGDVSIVNCVQPHPSACFIASSGIDSGVKLWSPLPELEDFVNPRKVTDIKAVVEANQNRMALDPLESMLVNMGYRIPTALHNEETDEENATGFDYQYFLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQI8</accession>
    <name>A0ABM5JQI8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ankyrin-3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500204.1">
        <property type="nucleotide sequence ID" value="XM_050644247.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500205.1">
        <property type="nucleotide sequence ID" value="XM_050644248.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644247.1">
        <property type="protein sequence ID" value="XP_050500204.1"/>
        <property type="gene ID" value="LOC126880407"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644248.1">
        <property type="protein sequence ID" value="XP_050500205.1"/>
        <property type="gene ID" value="LOC126880407"/>
    </dbReference>
    <dbReference type="GeneID" id="126880407"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59302" checksum="1E4BB83AC7859EC0" modified="2025-10-08" version="1">MDSSESLLMLAIDHGDYAEVARLLDNGVDIHFTESTGFSPLHKAVEKRYLEIVELLLKRNANVNASLNRFNQYVPPPLHLAAVCGRLDVLTLLIAYGASLETKSMDGLLPIHIAAQKGNFNIVKYFVENKLYHVDICGNNLRTPLICAVVGGHTEIIEFLIQCDADVKKADVFDTTALHYACQENLKDIIEILIRRGSNLDAKTYNGETPLHICVRKGYLEVAKRLIESGARSHLEGGVSGNSPLHLAAQYNQQEILEYIFKMGISANFQTVDGYCLLHVAARFNQPQMVKLLLQNGANIEGKIISRGTTALHLASSSNCCDVIKVLLNKGADVMAIDKKGRRPLDFVYEHFNADPNEMRRYDMKCSAELLVKHMLLFYKDIEVTTPSNFPSGTSINEFKQKCQEEIEQMKTCLIENTTVSLYTFLQALRNRNKLLKFLRNHELQEEMKNIKQYIEKYPIYSSLLPMVLDEVHNGMKRLLLLEKAGTAMDIMVPNLILECKINILQMLNNEDLSSLIESVKVEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQP9</accession>
    <name>A0ABM5JQP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500265.1">
        <property type="nucleotide sequence ID" value="XM_050644308.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644308.1">
        <property type="protein sequence ID" value="XP_050500265.1"/>
        <property type="gene ID" value="LOC126880447"/>
    </dbReference>
    <dbReference type="GeneID" id="126880447"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="192"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="379"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="794" mass="88267" checksum="6C9E7D43F8DDB23E" modified="2025-10-08" version="1">MVLWYRDGHSKPIYSFDVRGRAFNKALHWSDSKIFGPRAYFVTVSKPAALTLDGVQLDDEGVYRCRVDFKVSPTRNFAINLTVIVPPHQLLIYDNSGRDVNHTVGPLEEKTDLILTCEVRGGRPTPTVSWFMNERLIEGHVEEIGNHMMVNKLKIAGVTRDHLNSSYKCQASNTKLMMPSEKTVRLELLLRPLSVEIINKPRQLIANEEISIQCEVEGSRPKALVTWSRDNRPFRRGRVIAQENETSVITTISFVPVPEDDNSIFKCVGENPKLSGVGLEDSFKLNVVYPPQVVLHLGNTLNPEDIKEGDDVYFECSIKANPKQHRILWYHEGLPVNQNMSSGIIISTHSLVLQKVTRYQSGSYTCLAANPRGETMSDPVNLRVRYAPVCSKDSEITIIGASLDEVIKVRCQVSADPADVSFLWQFNNSGESFDVSPARFATSSGNVSELMYTPASQRDYGTLTCLGSNKIGRQVEPCIFQVVPASKPTSLTNCTLRTVNNQTSETVEVECRAGYDGGLPQRFVLEAYDAHTMRLRLNQTLSETDVPVFRLDIGEMLPSPPSLRIIVYAENAKGKSEKVVMDDILLNDAEKRTDGSTNVSLVPLAGLLTGSLLTLGLAVLVIVVVAVRRKRECDGRMHCPHHLNIDASKQNAKSRQSSMLEINTGDNRYVVAYTLKPASDCAPSPIQQTTMSPSDPYRQPDILNTPRGTESTQSTLPRPERLYTSLDGNSRHQLNCTPSISIANKQSPVQPSELSTNTLGRSRPRPRDPSYTNFTTMRRDHIIADSIPGPESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRT8</accession>
    <name>A0ABM5JRT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050500645.1">
        <property type="nucleotide sequence ID" value="XM_050644688.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644688.1">
        <property type="protein sequence ID" value="XP_050500645.1"/>
        <property type="gene ID" value="LOC114331986"/>
    </dbReference>
    <dbReference type="GeneID" id="114331986"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="476" mass="54108" checksum="56C1AE9B666AAB15" modified="2025-10-08" version="1">MGTEYKHADINMDDSGNSCGSSVVSDYSGPSYADVDGVQVSDIENDADSHVLQCGIEDDSDDDELGAMKDLTINDYINTSVNTKQQNDLESQQRLAVLSFEQVNRLNEVMDEVVFIHGRGNFPTLEIRLKDLVNVVREKLEADTSAGGAGMKVKDIRLNGGAASHVLATESQPYNDLDLIFGVELSSMRNFDRVKSAVLSSLYEMLPEGVNRKRISTCSLKEAYVSKMVKVNQNIGGDRWSLISLGNSRGRGVELKFVDCMRRQFEFSVDSFQIILDSLLLFYKCSELPISENFYPTVVGESVYGDFQEALYHLQKKLISTRHPEEIRGGGLLKYCNLLVKNYKPARPDYIKSLQRYMCSRFFIDFPDISQQRGKLENYLWNHFVEPDEEALRHQYLMLLHDVVEESTVCLMGHERRQTLQLIKNLAWQVLYQDQQRMMTQQPPPLVYANGIVYAPIIQTNCYCTCNTTWMPQCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRY8</accession>
    <name>A0ABM5JRY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeotic protein proboscipedia-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500709.1">
        <property type="nucleotide sequence ID" value="XM_050644752.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644752.1">
        <property type="protein sequence ID" value="XP_050500709.1"/>
        <property type="gene ID" value="LOC126880710"/>
    </dbReference>
    <dbReference type="GeneID" id="126880710"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16434" checksum="036D912E6D0E7C9C" modified="2025-10-08" version="1">MPTGHLDEEDFVAVKTRSNTPEGAAAGGSGNFWLSAVPAAAQPLEGCNETGFINSQPSMAEFMTALPHLSGELPHGPPMSPQQTPPAGGYPMDVPHGMGSPGVNVPEYPWMKEKKTTRKNNQQVSSRLHLQAEAKVVLPKCKTKTRPQYKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS89</accession>
    <name>A0ABM5JS89_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500808.1">
        <property type="nucleotide sequence ID" value="XM_050644851.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644851.1">
        <property type="protein sequence ID" value="XP_050500808.1"/>
        <property type="gene ID" value="LOC114344033"/>
    </dbReference>
    <dbReference type="GeneID" id="114344033"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="120" mass="12919" checksum="A24A8E5C2F91CC6F" modified="2025-10-08" version="1">MEVLKLGFALVAISCISYYVLIPVGAKNFDPHHVRPDTPTEQPIPDSPTLGHAHHQHHNGHNGHNGHNGHNGNNGHHGHNGQNGHHGQNGHHGQNGHNGHNGHNGHNGHNGHNGHNHGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSD9</accession>
    <name>A0ABM5JSD9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500845.1">
        <property type="nucleotide sequence ID" value="XM_050644888.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644888.1">
        <property type="protein sequence ID" value="XP_050500845.1"/>
        <property type="gene ID" value="LOC126880823"/>
    </dbReference>
    <dbReference type="GeneID" id="126880823"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="455" mass="51897" checksum="4CF88A6DF39E5CF1" modified="2025-10-08" version="1">MLAPRHKNNINLIERELCVLKNKFQNDQIMLTEVNNLSSRIENISRRKVEYKDTDFGPFLIMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMVLNSTEILEKGFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNVKIISARRLNRRVLDSNGTVTYIPTGTVQLLFDVRTPPKEIIIYSNLVTVDPYIPPVQQCFKCLRFGHSQRQCRGKARCPKCSDEHTVQSCTVSVPKCLYCDLDHLATNKICKEFERQKKINEVMVFQDLTFFEAAKLFPPIKEKPENSRMFQRRSRDFPSLLYSSPRAFTQALQKSPSSTPHFQSQSHVVPVKRKNKVILKDISYDKEAHKALLNEDLSRNLPRLPILNKLNDSQKYTGSQGPSFALSLTRNRVQSQDSVFSKNVDLTSDNNIEFAGFDESHNTSNFSKSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSM3</accession>
    <name>A0ABM5JSM3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500939.1">
        <property type="nucleotide sequence ID" value="XM_050644982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644982.1">
        <property type="protein sequence ID" value="XP_050500939.1"/>
        <property type="gene ID" value="LOC126880907"/>
    </dbReference>
    <dbReference type="GeneID" id="126880907"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="155" mass="18135" checksum="D95D34BA29CD8EE6" modified="2025-10-08" version="1">MVDFSRFAKVLTEIKREFDERFSEFDAVKPDLELFNNPMGVNIQNQSAEYQLELCELQSDSFFQAKKNEDISTFWKLVSKDRFPKLRNFALTILLFGSTYIICESIFSTLKHIKSKTRNRMENDSLKACIRLTTTSIDIKLQKLVEDKPLPQISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JW64</accession>
    <name>A0ABM5JW64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502179.1">
        <property type="nucleotide sequence ID" value="XM_050646222.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646222.1">
        <property type="protein sequence ID" value="XP_050502179.1"/>
        <property type="gene ID" value="LOC126881751"/>
    </dbReference>
    <dbReference type="GeneID" id="126881751"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="76170" checksum="B6098B7CCECEE589" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQSTVATAKVRLPEITMQTFCGSFSEFNSFYQLFEIIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFSTHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKASFFSSVDQPSHSFSDNNNCIFCKSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSSNINRQALSRERNAQTPQNSQGASRVVAPISTQHSFNNRSQNEASTSSSRPPLDMQKSPDSQAATSLSALSVKTDVLLATALLQISTISENTSLSNEMLNLEFFPYNVKDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKIDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFVQSEPEENQLDKLLQQFFEIEEVPLVSKLTPDEELAEQIFSKTTLVLPSGRFQVIQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWY5</accession>
    <name>A0ABM5JWY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein zer-1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502454.1">
        <property type="nucleotide sequence ID" value="XM_050646497.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646497.1">
        <property type="protein sequence ID" value="XP_050502454.1"/>
        <property type="gene ID" value="LOC126881860"/>
    </dbReference>
    <dbReference type="GeneID" id="126881860"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056845">
        <property type="entry name" value="LRR_Zer-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25013">
        <property type="entry name" value="LRR_Zer-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Zer-1-like leucine-rich repeats region" evidence="3">
        <location>
            <begin position="205"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="406"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="87715" checksum="02D938AABA573E72" modified="2025-10-08" version="1">MLQNKCRHSPVLPNEICSFCNTTTPETLLDICFDYINKHPGTICNPNVSSKELQLMDGLSLPVEICERLLNVRNNSLTPVDSNFINLFSNTDCTRLKRVKLRQTEIQDQDLETLLQHSLIELDLSLCPNLTSKCIHYISYYSSNLQSLSIGEETDIFPVRQFGMVFGMSPLDQEFYEKGYIFLAPNLRRLTLKGLHLLNPDFYKILLQPLSSLTHLDLSNCSDLYDFLYTQHLVNLTSLILYNVEGIQSKIPAICKLTNLRHLDISTSQSRSGQGKYKKGNTILKSIVDSLPKLTSLDISGTNLAGRGVAETTNGTMCDIPGLSSRANNPFQYLGLYETSHDACLRHDIPAKLIGGNANEEQILVAALTYLDRTDMLQKVMNELFHLFRLENIEYLGQALNIVLEAMNRHLHERHIQISGSATLFYIVKGTGNELHDDVKVKRKIITTLLNGMSIYRNDETMMRNGCLTLCQFRIPTDVLFDYVRLVDILLYSVYGMAQESFVQRIGIYLLNSLACQVDGQQKVKLGALGAINRMIWLIKERLERGICDDVLEVAWSTMWNVTDETPLNCKKFLAQDGMQHFLQCLEKFPNKEDLLRNMMGLLGNVAEVRELRHYLITPEYLSVFARLLESQSDGIEVSYNSAGVISHIASDGPDVWTVQEPSRHYVLSKMVEAIESWNINSQRNINYRSFEPILQLAKVYHTPECQHWAVWALANLTKVYPEKYCGLVEREGGLRLLKELIYQPMVPPRVKVLASMVVENCRNFQDTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYT2</accession>
    <name>A0ABM5JYT2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">10-formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="9">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10181"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="9"/>
    <dbReference type="RefSeq" id="XP_050503103.1">
        <property type="nucleotide sequence ID" value="XM_050647146.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647146.1">
        <property type="protein sequence ID" value="XP_050503103.1"/>
        <property type="gene ID" value="LOC126882285"/>
    </dbReference>
    <dbReference type="GeneID" id="126882285"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011407">
        <property type="entry name" value="10_FTHF_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036489">
        <property type="entry name" value="10-FTHFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="916" mass="100958" checksum="4D37B31E06101DB4" modified="2025-10-08" version="1">MPPNVTTVSTVSPLKVAIIGQSAFAVDVMHKLNQHGHIIVGVFTIVDKGKREDPLAKAAAENDIPVFKIKLWRRAGKPIPEVLEQYKSVNADLNVLPYCSQFIPMEVINYPRLKSICYHPSILPRHRGASSINWTLICGDKKAGLSIFWADDGLDTGPILLQEECDVQENDTVDTIYKRFLYPVGVSAVARAVDMVADGNAPKVVQSEKGATYDPMLNKPELQKIDWNKTALELHNFIRGMDSVPGASCLMKLPDSADYQEALLFGSSLWKTAIPIGKEILIEGTKPGIIHEEGLLLTGSDGDYVNVKRVKINGRMKNASVLDQITKQVDIELTPEEKVLIESVRAVWEAILNIDIEDDTDFFASGAGSMDVVRLVEEVKELFKTELENEDVFMAPVFSEFCVNVVQKSRGGKGEIKVEYRAIEMEANKMKLRFPCQLFINGEFMDAEDGKTTQTVNPATEEVICDVQCASKNDVDKAVAAAKNAFENGEWSKISARERGLMLFKLADLMQEYKEELATIESIDSGAVYTLALKTHVGMSIETWRYFAGWADKIEGSTLPVSHARPNRNLSFTKKEPIGVCGLVTPWNYPLMMLSWKMAACLAAGNTVVIKPAQVCPLTALKFAELSVKAGIPPGVINVVTGSGSVAGQAIADHPHVRKLGFTGSTEIGQVIMKSCAESNLKKVSLELGGKSPLVIFSDCDLDKAVRLGMQSVFFNKGENCIAAGRIFVEDSIHDEFIRRVVQETRKIQIGDPLNRSTSHGPQNHLAHMKKLLEYVEIGVKEGAKLEYGGKRVNRKGYFFEPTVLSHVEDHMFIAKEESFGPIMVVSRFSNGDMDGVLKRANTTEYGLASGVFTKDISKALRFAEKIEAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGREALNEYLKTKCVTIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZV0</accession>
    <name>A0ABM5JZV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503468.1">
        <property type="nucleotide sequence ID" value="XM_050647511.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647511.1">
        <property type="protein sequence ID" value="XP_050503468.1"/>
        <property type="gene ID" value="LOC126882543"/>
    </dbReference>
    <dbReference type="GeneID" id="126882543"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="763"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="911" mass="103237" checksum="AD442E46D5BAEF31" modified="2025-10-08" version="1">MALELETKRRTVLRTVFTTAANVLDNLLSETVDTRPWQQTSVQWELLQVKYNELCVVESAVFEAMVEKASEAELISEMEAKDRYSTRYYELKYKFEDRPSLVSSESSLKAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEESAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKCKSNNLVEKKNIKLPKQGTDQQSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKRCRARLNCILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLWELDIIGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGTRCINGSPKEIEQDEGPVKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K005</accession>
    <name>A0ABM5K005_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503520.1">
        <property type="nucleotide sequence ID" value="XM_050647563.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647563.1">
        <property type="protein sequence ID" value="XP_050503520.1"/>
        <property type="gene ID" value="LOC126882590"/>
    </dbReference>
    <dbReference type="GeneID" id="126882590"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="407" mass="46749" checksum="BCEE1F553F38D1DC" modified="2025-10-08" version="1">MAMANKDLDVSSGSTTINMPVQVNPPEKFTFSQPNMWPQWRKRFQRFMSVSGQDQKPEKDKIDILMYIMGDEAEEIVLQFPKIPATYSEMLQSFENHFIPRRNVIFERFKFNSRIQQPGEAIEHFITSLHSLAEYCDYSTLKEELIRDRIVVGMSDTKTSERLQLQGTLTLKDCIIVAKQAEMQANQTLELRNENRYHPTQEVAKVAVQNRERGNVTGSFQKADNIRRKNFQGDTCMFCGQQSHSREVCPARRSQCNKCKKFGHWASVCLSGKGQRENKVSTVEIDNFMINSEGNNLNFVGSVYINNIEAREWLISVLVFELRTKFEFLIDSGEDVSCIPSSLMPKEILKTLCKPYQKVTGPSGIKLEVVGTLPVTLCHNNDISKTQMLEICRQYCEDDFLTEKGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3U1</accession>
    <name>A0ABM5K3U1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050504858.1">
        <property type="nucleotide sequence ID" value="XM_050648901.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648901.1">
        <property type="protein sequence ID" value="XP_050504858.1"/>
        <property type="gene ID" value="LOC114342836"/>
    </dbReference>
    <dbReference type="GeneID" id="114342836"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18644">
        <property type="entry name" value="CD_polycomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052458">
        <property type="entry name" value="PcG_PRC1-like_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389:SF3">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="386" mass="42218" checksum="22946D33325DF6C9" modified="2025-10-08" version="1">MNLMVGDDRVYAAERITRKRIRKGVVEYLVKWKGWSQRHNTWEPEENILDNRLIELYEQNHRPDGTLKRGPKKKHHSSSAVAPVAEDTEDEGVRSGEESQDEGPSETVTPAPPAAKGKTKHEATARVEDDDTRAGSEETSETVVAPTTESVENENSNSSSSEDRRPLLARMDVGTKRKAEVLSKESGKIGVTITTSPTSSSPPPVKAPKLSSKQTSAASRTNERQNSKAEEESSAIPSASSPAVLTATAPRTSTDKRQVPADATLSATLPHSSTKEPASPKPIASRTDEKRPEKKPEPKPENGQPEEKPIAVNGHNININNNTIPNDVPSLTSPSSEYWLARNPVADQVFITDVTVNLKTVTIRECKTEKGFFKDRDDKSHPSDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K536</accession>
    <name>A0ABM5K536_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505299.1">
        <property type="nucleotide sequence ID" value="XM_050649342.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649342.1">
        <property type="protein sequence ID" value="XP_050505299.1"/>
        <property type="gene ID" value="LOC126883681"/>
    </dbReference>
    <dbReference type="GeneID" id="126883681"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33841" checksum="7CF2C2630D1025D8" modified="2025-10-08" version="1">MAENQAGSHVLANMATVSAPSEFNFSLPGSWNQWKKRLERYMSVSGFINKPEAEKIDMLVYLMGAEAEEIITQFNLTPTQQVYSIIIEKFDAHFIPQKNVIFERFKFNTRSQQPGESVDAYITALHSLAEHCSYGALKDELIRDRIVVGVLDVKVSERLQLQKNLTLGEAVLTVRQAELQNSQNRILRQERVQEVATVNAHRGNYWSQSQAEPNKYGQQNTWGKSNKNYKCTYCSVPSCNSRERCPAKDSRCRLCGKKGHWQARCRSGRNVRVVEGQNCAESEVGIENEMENLQVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5K1</accession>
    <name>A0ABM5K5K1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505470.1">
        <property type="nucleotide sequence ID" value="XM_050649513.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649513.1">
        <property type="protein sequence ID" value="XP_050505470.1"/>
        <property type="gene ID" value="LOC114326877"/>
    </dbReference>
    <dbReference type="GeneID" id="114326877"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="368"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="655" mass="75583" checksum="7F9D700660DD0204" modified="2025-10-08" version="1">MVFLNEYDVNIVLLNETHLKFSQHLHIPNFYCYRDDRIDGWGGIAVLIHQSLAADRIDISHIHLPEKWQAIIIKFEKFFIIGSYKTPDVRFRKEIFRELVQMCDKPFFFIGDLNCQHSLWGSSSNNPNGNRLADLLEEDNLCFLNTGEATRISPPDSNSVPDVAIASPGLAVDCLWEVFPEIGASDHFPFVVCYGQDRNSPQGNDPLQDRSIFNVKKANWEQFNQYIESNINNIPNESYTDFQNLILDAANRFIPKKKRVRFHKPQLPWWDEECSVLIKSKREAVKKFKQVPSLENFINFKKIRAHCKNKELKSKKKKSFVVFCSTISPDTPISVMWRKISPMAYETVNMGKEANNQTKFMEWYLNNWSEYKLIFTDGSKDKQGNVGIGIYLTERTQLTARLPSANSICSAEVFAIKKALELIQQNNFTKCLICSDSKSALEKITRPSYKAAIDSQTLQLKQKLCEFDEQQREIKFAWIPSHTGIIGNDRADHLANLGIKLPISEEPKAPFKDFQIKYKENLWIGWENRFQQIGQAKGITYCSQVTVPYKKAWFTKFPNLGRGIITQMCRMRSGHCSVPVHLFRLKVVNSNQCLCGSVGTLQHVLLECTRFQRESQLLRRELERDPTLTDVLFKNLNSKTLIAVQKFLTSTMTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5K7</accession>
    <name>A0ABM5K5K7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505459.1">
        <property type="nucleotide sequence ID" value="XM_050649502.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649502.1">
        <property type="protein sequence ID" value="XP_050505459.1"/>
        <property type="gene ID" value="LOC126883828"/>
    </dbReference>
    <dbReference type="GeneID" id="126883828"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="340" mass="39956" checksum="9E17E1A3AF152304" modified="2025-10-08" version="1">MTDFSKATNAMCMIMLDIMGVFKIVFLWFKTEKLKSLFNIILNDFWPYDLINESKRRVKDMFNLMNIFVVWFMLAGVMFALLSLSSPLFSNKQLPYDVRYPFDWTVSPWYEIIYCMQTFTHGITMTTIGIGAIYMVIGILLSISSQYCILEECFEIFNTPEMYSVNKKLRDILNDGLKNKYTDERREYFVRCVKHHQLLLRFTKELNDELNPLELFELALSIFALCLGSLRIANAESLGSNVEQAGSYLYLIGYTMQLFIDCFFGTFLYHQASLLPDAIFHSNWRTLDDEELRKDFVFLLQNSQRIPQINAYNLYDMHMVSFIKVIKVAFSFYTMLSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6B1</accession>
    <name>A0ABM5K6B1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505726.1">
        <property type="nucleotide sequence ID" value="XM_050649769.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649769.1">
        <property type="protein sequence ID" value="XP_050505726.1"/>
        <property type="gene ID" value="LOC126883995"/>
    </dbReference>
    <dbReference type="GeneID" id="126883995"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="501" mass="56499" checksum="15165E8F5F9F98EA" modified="2025-10-08" version="1">MAGKDWLQAFLKRHPNLSLRKPEATSLGRISGFNAESVGLFFKNLNIVLTKYNFQACRIFNVDETGITTVQVPSKIIAPKGVKQLGKAVSWERGRNITLCCSVSASGIYIPPMFIYPRIRMSEQLKRNGPVGAIYECSAKGWMTVELFLIWLKHFKKHASTSNDNPALLLLDNHSSHCSLSAYEFCRENGIIMLSFPPHTSNKLQPLDLTFYGPLKSAYSNECSLYMRRNVHKKITPFDVSEILNRAFVHVATMEKAQKGFEISGIVPYRPNIFTDEDFLPSTLSNIPAVELQLPEDELTPCTSETNRVPSKDAVLETNEPNVIPSTSKANEAHADVTPSTSKSGLANERQGDISIEEMTPLCVITENKLKKRGRKLGISKILTATPEKIELEQKENRKIQKKEKQKLSKNVKHVNKKIKRVTRKVFDDSSSSGSSLHDEMEICNDHSSDDPSSDVEEECIYCGEYGKSEMWYRCGVCHKWAHKECSGYDNHKSFICDYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K713</accession>
    <name>A0ABM5K713_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505981.1">
        <property type="nucleotide sequence ID" value="XM_050650024.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650024.1">
        <property type="protein sequence ID" value="XP_050505981.1"/>
        <property type="gene ID" value="LOC114325073"/>
    </dbReference>
    <dbReference type="GeneID" id="114325073"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046494437" description="Chloride channel CLIC-like protein 1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="74120" checksum="0674D2DCCE105167" modified="2025-10-08" version="1">MEFLHILVILLFGTATKAYKENLVDPHEMVMDTGRHRKYVDEEMVLKRSFSEGDLHEKQECYKPSLKEETMAIMYLKRTITLLLSSSSLEPNSADEYTGSYHYQSNSEEHEFLKSFVNSKVISEEHMRRLDTVLSTVFSKPNQDSMFKFNTCISREDLAEIFNTKFLMGLFIVIGSIVSFVFLKNNYGFWFIIGYFVMIMLIVDYGKRYYDLYEAAEEHNLALKYDSVCDTTKMTWSEYFKFSLSQKNCERKIVTPLEVGLHQLKHIIIVPLEAAGAGMGKFGAQLWDKLPFPWNILMFPLMLLFVLGLVFLYVLAVKNTSFKLKLLHMFNLEMGGDRNEENRIGGPTLDRFLQTLNHRPLIEVQEVDEEEEELRAEDTISTPPNEEPKKIIENRTPQKVEEKRVSDNSYSRTKDEKIQNLIKWLQTSEPYAVVLPKQHLQAEDTRSTPPKEEPKKIKENMTLKKKEEKCVSDNSDPRTNAEKTTDILGFCKKFLQTSSTPPKEEPPKKMIENRTPQKVEEKRVSDNSYSRTKDEKIQNLIKWLQTSEPYAVVLPKQHLQAEDTRSTPPKEEPRKIKENMTLKKKEEKCVSDNSDPRTNAEKTADILGFCKKFLQTSSTPPKEEPPKKMKENTTPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8X2</accession>
    <name>A0ABM5K8X2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506634.1">
        <property type="nucleotide sequence ID" value="XM_050650677.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650677.1">
        <property type="protein sequence ID" value="XP_050506634.1"/>
        <property type="gene ID" value="LOC126884619"/>
    </dbReference>
    <dbReference type="GeneID" id="126884619"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="333" mass="37764" checksum="125A4579A8E9BE81" modified="2025-10-08" version="1">MPCTKCRSDFNLFNWKIKCGECEDKYCNKCLKRREGVLYCEKCLILLKRPPDRSKLMELKSKDLQDYLNKRNISTYGLVEKQELVDIFCNKHIPEKPKRGVEKLTANFAGSLPNLRPLNEIFGNIESIITNDGNSTRQSRPPRQDQPRSTPRSPQSPQSPQHPPMSNSTPQSPQNHPSSHTPPSPQSQPTTSTTAPDHRTNITEEEPPAQGSPLPPRYPKIEDFGSAEELHNLSSKDLKILLTLNRVDFKGCVEKTELLERAERLWEDTNESKKEIPENLPIGELCKLCMDAPLDCVLLECGHIATCTDCGKKLAECPICRQYVVRVVRTFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K995</accession>
    <name>A0ABM5K995_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506761.1">
        <property type="nucleotide sequence ID" value="XM_050650804.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650804.1">
        <property type="protein sequence ID" value="XP_050506761.1"/>
        <property type="gene ID" value="LOC126884697"/>
    </dbReference>
    <dbReference type="GeneID" id="126884697"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF106">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="465" mass="53253" checksum="250EFC783BA8F55C" modified="2025-10-08" version="1">MTTSVALFQCRLCLNRTPSRVNIFGGDFPRMIEVLTSIKVHEEDGLPKYSCTKCAKEVQLALMVKKRIIKAHQLLLEALRKKRAIVQRIATTSIVNKVQSSVPKKTNTTKQKVVSKKTNPIINQNRTQSKSKLFDNSNEATTDEDANDNSNEATTNEDANEGSVKHDIKIEVVEKTNQPNTIKEEKGLLEQDVNEILDAAQKHIKSTVSTCKICNLTFSDKPAYYLHNLKHIKGKCHICGRVMRRDNLKKHIMMHTAGPSVCSTCGATCKNIESLRGHIFNYHKHTAQQYVCEECGRSFRRKHIFLLHKKKVHGGVRNFKCSTCGKTFFTNTDLLKHIRMTHEKLRPHVCEYCGSGFSSKYALKTHTRQHTDEKPFVCQHCFEGFRQRVSLRSHLKSRHGIEEAKEFVCKICEKGFATDYALNIHQRLHQTKKCEICSENFGGDEYLTNHLREVHQVEVEMRQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBH4</accession>
    <name>A0ABM5KBH4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507539.1">
        <property type="nucleotide sequence ID" value="XM_050651582.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050507539.1"/>
        <property type="gene ID" value="LOC126885155"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507539.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8338" checksum="79139C3B485DB4FE" modified="2025-10-08" version="1">MAGGEVSKTTKPQLRGLLAGQIKWNIIIAATMAAAAAIAQKVFVNDQRKKDYAAFYSAFSAPGLMEGYYKSGLHISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCS2</accession>
    <name>A0ABM5KCS2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507975.1">
        <property type="nucleotide sequence ID" value="XM_050652018.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652018.1">
        <property type="protein sequence ID" value="XP_050507975.1"/>
        <property type="gene ID" value="LOC126885447"/>
    </dbReference>
    <dbReference type="GeneID" id="126885447"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56163" checksum="E8BC27FB1446FB22" modified="2025-10-08" version="1">MGFFRRTYLRRHRKQCPARSKCKTVKRENHLSLSQVFTVCSGVHGDFLASLRLKKEVFPIMQSDEISRTAMKDMLICSYAESLLRKHKRAQIRNVISNKMRELGRLLISLRNTTGIQLLFDALKPQFFDNIVGAVKVISGYCEETKTFQASSLALHMGTTLKQVCDIATKNIIQKSPIIICTTAEESLKDIKRLKNLIENHWTSEISSLALKNLKENNYVSPKLLPLTQDVIKFQTFVMNEAHEASDALKKNIHIKLNYRKLIESVLALTLLINRKRIGEIQYLKTETYNSTVSENQQTEFLDCLSKTEQTLCKNYKRVVTGGKGSRPVAILFPPDLQKFIELLLSFRSICVTPTNPYLFGNPNTELWLSGYHIVKKLATKADVSDTTLFTSTRLRKQIATLLQAINIKDDEMEQFATFMGHAKKAHESYYRLPQDLYQTAKVAKLLIAVNSGQVAKYKGKSLDEITLSDNESLLDETEAEKPLFHVHILGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KET2</accession>
    <name>A0ABM5KET2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508707.1">
        <property type="nucleotide sequence ID" value="XM_050652750.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652750.1">
        <property type="protein sequence ID" value="XP_050508707.1"/>
        <property type="gene ID" value="LOC126885934"/>
    </dbReference>
    <dbReference type="GeneID" id="126885934"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="628" mass="74117" checksum="98558E54A969F877" modified="2025-10-08" version="1">MEVKQEFSEKTCKVEIEYNDLNEALLDGSKCEVEEQSNTQTTHDTYDYADFKESSRHSEIYQDISKLNPIEENQKSEKGFTQEDNKMKIMKTFGEYSSHKEHCTSQRAEEKTINNIEVQARTRPYQCEICFKQFSFGHNLKKHLRWHTGQKHYKCEICFKNFSESSHLKRHLKVHPGEKYYKCEICFKQFSEGLHLKQHVRMHTGDKPYKCEICFKKFSKSYLLKRHLKVHIGEKPYKCEICSNQFIIANDLKRHLRVHTGEKPYKCEICLKQFSQASNLKMHLRVHTGEKPYKCEICLKLFGDASTLRKHFRVHSGEKPYECEICSKQFSRANTLKAHMRVHTGEQPYKCEICFKRFSESGNLKKHFSLHTGEKPLKCKICFKRFNERHHLKVHIKTHSEETSYKCEICLKQFSEACNLKDHLRVHTGEKSYNCEVCFKKFSESGNLRKHLRLHTEKKPHKCKICFQQFSEVSNLKKHLKVHTGEGFYKCEICLKLFSCTGNLNQHIKLHTGEKPYKCKICFKQFSQASNLKTHFRIHTEEKPYKCEICFKRFSVADHVKSHLKVHTGEKSYKCEICFKLFSQASNLKVHLRVHTGEKPYKCDICIKTFSGSSNLKKHLKVHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEU2</accession>
    <name>A0ABM5KEU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508717.1">
        <property type="nucleotide sequence ID" value="XM_050652760.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508718.1">
        <property type="nucleotide sequence ID" value="XM_050652761.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652760.1">
        <property type="protein sequence ID" value="XP_050508717.1"/>
        <property type="gene ID" value="LOC126885939"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652761.1">
        <property type="protein sequence ID" value="XP_050508718.1"/>
        <property type="gene ID" value="LOC126885939"/>
    </dbReference>
    <dbReference type="GeneID" id="126885939"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1189" mass="135416" checksum="2E1F8913E609D929" modified="2025-10-08" version="1">MAVSWKLENTKTKEVVDIEKSVFKIGRHQGADLKSESVTLSREHAEILQTEDGFLYVKDNGTINGTYINEQRISPLRNVPLKHGDNIVFGVFSLMKKPNFRGPYLTYRVIKESVEDKIADYTMNDDDIAIIISDDEDDDLSKSQIFHISERIKSEPIFSDQFLDPYIDIKEEVKEMDYCSQFYQKVDLTEKDHFDSTSDLLQLLESGTANSREAVTDKNIEQNISDKSDESIEQNIFDKCEKELRVVLASLPVPEEEVIDLDVTPNKEQTLNASESVLGEYAQVNGDEQKNNKKLHVVLERGAKVNTDEQKADKNLHVVLEKITAPKQIKPPLVEPHFEESPRNRRKTLKRKSLDDSKEEPFKKPNNNTSLEIAETSMRETRKQRLREIADKAEKKTPSPKSIKGIAKVKLSESRGAFLIQSNTVPASTNVGKSSKDPRLNKPESKPVNNTTTRKPLETKVNNRLPPVTQNISLPGKEKVGLIYQISNRNAAVAIPTNVRRHYDLSDDINVMLYWNVTWILEQSKGIRSPPVTDNKPAVRIPSTFRNIQHYLDVMKPCILLEAWQYIFQSTFRNDEGKQNIPYHYVRVEHTRRCEKTVTFDCVSENTSFRPDDLCVVNFCVSINGSRHSKDNFGYITNVHNRDKLMKFSIVLKPPSGPLVGNKLTVKVIANIANILRQFRTLRYLEQSPLLNYILEPERLSTLMPIHGRITRKEFSLNSIQQKTCAEASELALGNRPGIYLIHGPPGTGKSSVIVSIVFEIIFKAMQRNESPNLLVTAPSNAAINALIEKLSEARSKLNDNDRRHIKLIRVGPETSMSEVAKRYSLREFTRKNILSSNKNALHQKYSHVAHQIDVNTFLKQELGDQYDYIIRNTEETLLSNANIICTTLNSSVSYILTNRRSNVKYTACIIDEATQCTEIECLFPIMLNVDKFILVGDPQQLPAVICNKEAQDVGFGKSLFTRIYENFVNNRDNSPMKMLCEQYRMNPAICDYPNRKFYDGALKSSPICTNPIQPHLKPYLVFNLMNPATSYNKSSEYENSNELDVVSCILKALNTHVVSTCKYSVGIITPYRAQVVLISRCIKEMKMNDNVSVNVNTVDSFQGTEDDIIIISCVRFSQNCFLANEHRLNVALTRGKKAVYVIGNHSLFKQCRPLYDLRENAKQRKVLLDIPNNPLSIPSFHKLILDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEY0</accession>
    <name>A0ABM5KEY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508756.1">
        <property type="nucleotide sequence ID" value="XM_050652799.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652799.1">
        <property type="protein sequence ID" value="XP_050508756.1"/>
        <property type="gene ID" value="LOC126885963"/>
    </dbReference>
    <dbReference type="GeneID" id="126885963"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="64" mass="7108" checksum="E51BFE168BBC3BFC" modified="2025-10-08" version="1">MNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEZ6</accession>
    <name>A0ABM5KEZ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508764.1">
        <property type="nucleotide sequence ID" value="XM_050652807.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652807.1">
        <property type="protein sequence ID" value="XP_050508764.1"/>
        <property type="gene ID" value="LOC126885969"/>
    </dbReference>
    <dbReference type="GeneID" id="126885969"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="320" mass="35640" checksum="B063236CD3E870DD" modified="2025-10-08" version="1">MSCLDCLDLGPPPDSILFLPPPPIPSFLQQSLPDLLLNTTPCSAAQICESTSAPNRIPESGDYMELPRKDVETWSGIGDTWLLVLVASSIGVLLLGALLAMFLLKCREMNMFGGNDCSLHRQMKNHEPRECTAVPTLNGTKIIHPTDTVLYHGTNIQDNRMVWATLTPRGTQHFISENYPPDLIDYGDEDHYETIDNIGAVVPPVPPYPKAIEKSSFDNSGFLDYEYEDPTPLIESYQLTNIEPDTSHYQMIGNADMRCSNLNTLRRHVPISRPRVSSPTRIEHPNLPPLNLYPHKGTLKKNGTLSYRAVEGSTLPKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFF7</accession>
    <name>A0ABM5KFF7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508920.1">
        <property type="nucleotide sequence ID" value="XM_050652963.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652963.1">
        <property type="protein sequence ID" value="XP_050508920.1"/>
        <property type="gene ID" value="LOC126886118"/>
    </dbReference>
    <dbReference type="GeneID" id="126886118"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="179" mass="21051" checksum="AA9A067BFF491CC4" modified="2025-10-08" version="1">MSSNSNSNISKDISHNNASEGEISESEDEISENSTNISNVQKEKRKRLKEMDTYHKELVRSLDTLTEQMKKMEAENKRLMNQIHQMQEENKFQMAKLEEKITGKDQEIQKLTQKLLETIDKNAKKEKQKQATVEEPTNIHEKERRKTSANSPNKENLIEIENNNAEWTAQHQQKKKQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFM9</accession>
    <name>A0ABM5KFM9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508995.1">
        <property type="nucleotide sequence ID" value="XM_050653038.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653038.1">
        <property type="protein sequence ID" value="XP_050508995.1"/>
        <property type="gene ID" value="LOC126886184"/>
    </dbReference>
    <dbReference type="GeneID" id="126886184"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="330" mass="38822" checksum="073192CD113DB0E0" modified="2025-10-08" version="1">MPKSQNELKLERLCSKRETIFRRAQLCYDAGSALEKDPENASKMRNFAVRYSTFEKTLSEYEEIVQDIVILKQEMEPDAGVAYHTHLDAFYDLYSNIEYLASLLINKPAVLSNNPNSTNNSTIKMPKFELVKFDGEDISLWPVFYENFKQFVHNKIEYPKSDKLQYLLSCISGKALKSCSSIEPIPNNYDIIWNMLVERYNDKKYLFNLYMDRIVNFRGLQSNNPSYLEIFLEKFDTNVSALKRLNLDNLDDHILTYLAMLKLPQDTIDSFDLIRNNNDLPAYDDLLKFLRQRVVNLLLKMIDQGIPKIIFRFKNRTNRFICKNRIRIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHM3</accession>
    <name>A0ABM5KHM3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509712.1">
        <property type="nucleotide sequence ID" value="XM_050653755.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653755.1">
        <property type="protein sequence ID" value="XP_050509712.1"/>
        <property type="gene ID" value="LOC126886735"/>
    </dbReference>
    <dbReference type="GeneID" id="126886735"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="294" mass="34820" checksum="7A60797BB8D012F1" modified="2025-10-08" version="1">MTFLSFGLKMCHYQTWKIIEQRRQLKVGSFDLNGYRSLSREIQRNCRKDKDKYVSNICQEVEIHLHRNETRDLLQKVKLLTREFKPRNYAIEDETEIEMNYEEEQKYLQRLLEEVNSNDELEYDDSADSSEEDEVEIQDLDTDSEQDIPEAENDVFDEAEAQNICRRIPIFLDESEEETEEDTEMKSEEDSEEDTDTEDTESEAPRKAERKSSQRKRSRRAVRKVALQKLETLFEDQQDQIENITYQSLIVLCDLSIGNINDGNTPESDKVKHNIMKMYLSNQQFKQLILVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI16</accession>
    <name>A0ABM5KI16_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509763.1">
        <property type="nucleotide sequence ID" value="XM_050653806.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653806.1">
        <property type="protein sequence ID" value="XP_050509763.1"/>
        <property type="gene ID" value="LOC126886777"/>
    </dbReference>
    <dbReference type="GeneID" id="126886777"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047240797" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="50"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="191"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="704"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="952" mass="93068" checksum="3CE0AC33C9ECC8FF" modified="2025-10-08" version="1">MMARRKCHLLVTFVFFQICLCNVVKTQDDDEAITKYKLTFLDEIESNLKQGELKCAALGMQLLSIKSKEKNDAIFKHVSKTDNTSCYFTGARRPAVNKAFEWPDKTNLGFRNFIKDLPNNDGKPIYAMPMIVVVKSNGEDLIWKDVPYNSKCKPICERMSDTEMDPGPQPPPNPDNITFTESLAKGKKSIESICRSSNIIETRGSPLYIKNEKQMNELHEILKFNDDRMRYYLPITKIDKKSPHMWDDGTPVTWFPNPINKKNGNLCVWVKYKPAKNATEWEDANCWQFKPVMCVPKGTSLSKVETTTEAEISTNASTEPSTSVDQNSSPPVPNPSDGDTSGSGSVSSGGSGSSGEAKTENGPPESTAGGDDSTSGSVSESGSGSSDGSVSAGASGLSEGDLTPDVPTETPPSGDAGISGSVSAGDSGSSDGSVSASASGLSGGAITPNVPTETPSGGDAVISGSVSAGASGSSEGDLTPDVPTETPPSGDTGISGSASEGGSGSSDGSVSAGASGSLEGAITPNVPPETPPGGDTGISGSVSAGGSGSSDGAVAANVPPEAPPAGDAGITGSISAGASGSSEGELTPNVPTETPPSGDAGISGSVSSDGLGSSHGSVSAGGLGSSDGGITPSVPPGAPQGGSGSSEGSISAGGSGSSEGAITPNMPPETPPGGDAGISGSVSAGGSGISEGAVTPNVPPEAPPSGDAGISGSISADGSGSSDGSISVSGPGSSEGAVTPNVPPETPPGGDAGISGGVSAGGSGSLEGAITPNEPTEAPPGGDAGISGSVSKGGSGSSDGSISASGSGFSEGAITPNVPPETPPGRDAGISGGVSAGGSGSLEGAITPNEPTEAPSGGDAGISGSISIGGSSSSDGSISSAGSGSSEGAITPNVSPKSPPSGGGSISGSVSAGGSHSTKGKLTSSGSYKTAGVDPRGNSKRCKCKNKNNKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KII2</accession>
    <name>A0ABM5KII2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-processing factor 39-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510026.1">
        <property type="nucleotide sequence ID" value="XM_050654069.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654069.1">
        <property type="protein sequence ID" value="XP_050510026.1"/>
        <property type="gene ID" value="LOC126886910"/>
    </dbReference>
    <dbReference type="GeneID" id="126886910"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="133147" checksum="A563C1CF86414D1D" modified="2025-10-08" version="1">MEETEASTGRKTRSSAAKTTPAVTKKEKPGPLSRKTRKKVVLMEVEVSDEEVDETVQEPVTETMETTEESKQSENQIDAEKVNGKENKPKSIDDQVILNDVTVFCEMQTENNKTEDTEKMEVDGDLEIKKTEDNVSSQQTDESKVKSSEKLDTKPNVSEPEVEEPAEKKIKLEEKPADTDSNKKEVEKESENDAIKTNKGCSEEELKTESEKNEKESKDVKEKTEEETEKKQDVAKVEETDAKVKENTDAKVKDAKVENTDSKVEENTDAKVEDANVENTDSKVEENTDAKLENTGAKVEENTDAKVEENTDAKVEEKVNKEEIKEEEIVKENTTEKSEMECEESKEVKEKENKVEEKEIKEVTTEDKSEKEDEKSENQNKKGDEESLVGDAESKGDLTKVEQKEAINTEGKQDTEKETFDKQKADPDTENISEDELPVVQAVKVPEAEEVSDEELPGPKRAELPADTEVVSEDELPTVKNDSKKESNKRKLATDYDPGSPTSENEAPSKKPSLDSSAEKDKEEKPKPKKLPELDKYWKAVNDDPTDFTGWTYLLQYVDQENDMEAAREAYDAFLSHYPYCYGYWRKYADYEKRKGNKKKCEEVFERGLKAIPLSVDLWIHYLTYVKVTRTDDEEFIRSQFERAVTSCGLEFRSDRLWDSYIKWESEAKRLQKVTAIYDRLLGTPTQGYTTHFENFQEHISNNAPNKVVDVDEFFALRKEVRQQLKHEITDTPPADNDAPPGDEDQTKVISSDEETKILRERIISIRRKLHKNTVTAVTARWNYEEAIKRPYFHVKPLERCQLKNWQDYLDYETEQGDRVRIIVLFERCLIACALYEEFWLKFVHYLENLRDHELQPKIRDVYERACTIHHLKKPNLHLQWAIFEEGVDNMSRAAEILVNLEKSVPNVLQIAYRRINLERRRGDHEKCCQLFEHYINSTKNKIIASSISIKYSRFACFMMKDVEKAQTILKTAIAKDPNNPRLYLQLVDVTLQKGDPTEKNITEILNMFLDKDGVDAEQKMLFAQRKLEYLEDFGSNLQLVQEAHEQYQKLVKQHKDGLKKKEIKSETTGPSSKSKEAKQPPPSSQGNYGNYNAPYGPPSNQPSYPPYSGNQQGPNYYPPQYGQGDQYQYQNWQYPPQGGYGGYNQWGGGYGGGGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKA8</accession>
    <name>A0ABM5KKA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510634.1">
        <property type="nucleotide sequence ID" value="XM_050654677.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654677.1">
        <property type="protein sequence ID" value="XP_050510634.1"/>
        <property type="gene ID" value="LOC126887260"/>
    </dbReference>
    <dbReference type="GeneID" id="126887260"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="312"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="854" mass="99979" checksum="D0E33972D62EBAF2" modified="2025-10-08" version="1">MPQGNSFRTTLRNRYGPIVCQNFRKLETFYEKLAHCQNSIKFLRRCRNNNIIPKGLRLRPAYSSRRLQNILHRASLSMIRERLQFHRSNLFFIEQDIVSIEDLLFGMISNSDFDRIIFSLHIIYENSYQKQRNIHLNKFNNLLEQNSLHTFDNLNRNNDILTTVVNLSNRHLNATENLVLSKGLNYAVTHPSIPKLDIISSVEKISQCLPTHEKEQYRVLCKLELEKSNQIEQNISKEEMKALKTLRNDDSITILPADKGNATVIMNKIQYEDKITDLITNGPYSKLTKDPTKTLENKIYRALFKFKNDLTYYQRKLMTPHYSKTPHFYGVPKIHKANIPLRPICSTINSPCSELSKFLLNILKPFANNDDTFIKNTKHFLNKLSTIEFNQNNILVSFDINSLFTNVPLDKTLNIIKTKLENDNTLATRTRLNVSAIMELLTLCTHNTYFQLNNEFYKQNFGLAMGSSLSPLLANIFMEDFENNIISKQNLKPTVWWRYVDDVFSIWPHGSELLDTFLNIINDQEETIKFTMEKEYNNSLPFLDVLISKKDIGYETQVYRKPTHTNRYLNYKSNHNINVKKGIIKSLYDRAKITCSNENSFLAEKQLLTSVLLKNDYPLSFINKELSRLDRMEQNNLERDPTTFTRNNTRKISIPYIKGLSEKLKTIGNKFNISTTFKTTNTLRSILSKTKPNNDQERTKNCIYKIPCECEQFYLGETSRPLDVRISEHQSYIKNREFERSQICQHAWDNEHRVQWRDSSIVLKESDSKKRKIKEAALIMLNETNCVANSSVECSRMWLPILKEEVNRKKIPRLFLGIKITFLPSGASSILRRRRYNQEDHIMTIYTATTNQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKG5</accession>
    <name>A0ABM5KKG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510692.1">
        <property type="nucleotide sequence ID" value="XM_050654735.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654735.1">
        <property type="protein sequence ID" value="XP_050510692.1"/>
        <property type="gene ID" value="LOC126887308"/>
    </dbReference>
    <dbReference type="GeneID" id="126887308"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="162" mass="17855" checksum="36DB5A702E615BDF" modified="2025-10-08" version="1">MVIEISDSTDAGKKLSNYLINTSDDAVAVPVDFINKTLECSRDDFMALVKSLPALLEDLSDVQVDAKKAADKIYNCIGHDVNTALCVLDVVSRFVDVAKILVIKTHNHIKPVADQWKAFVNSIINCGKGNIDIYNVAGDKWLQTVSNCVSAYTLNKFKVIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLX9</accession>
    <name>A0ABM5KLX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050511202.1">
        <property type="nucleotide sequence ID" value="XM_050655245.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655245.1">
        <property type="protein sequence ID" value="XP_050511202.1"/>
        <property type="gene ID" value="LOC126887635"/>
    </dbReference>
    <dbReference type="GeneID" id="126887635"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="549" mass="62329" checksum="64F197B45C770054" modified="2025-10-08" version="1">MEATQNQYYKYCIVHLCSNTTYKTPGKLFIRVPKDQKRRLKWLKACRKNEKDISQKTTAHVCEDHFNLEEDIDNYVKYKLMGGPKKMKPNVVPHIFDCQQSRKRSFENHPRAAGTKRTAKRIVDEAISLVPQDPVCIQENLGIVACSSKTIHPMEIQLETKNDIEVSKRDVSSQTRPSVRTKGVQCNLHCGITVALSPIRIIPDNIEMKPSTSYVTNISETTLSIQSSGHENFSESVSGSSEYTLTPGEVKKLNDEKRTEFKNLTMNCTITKLQNRPRLYMGLPEHAYYTFQLLEKYCTVNSMYIFLTLKKIRTGLSFLTLADDFGITESYASKIFSKSVPIISKYLRKCIIQPQVSFVKSNLPIAFRARYCNIYCIIDCLEIEIEKPTDAVKQSLTWSEYKKCNTLKYLICCTPDGIINYISTAFGGRTSDAIIAEHSGFLNSLPSNVAVMADRGFKHIDHLLRSKGCVLIRPPSVSVGTKPSKDEVFETKRIASLRIHVERVIRRLREFSFLAPHACIDNKLLCYSDNIIKIVCGLINLQSGIISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KM51</accession>
    <name>A0ABM5KM51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511275.1">
        <property type="nucleotide sequence ID" value="XM_050655318.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655318.1">
        <property type="protein sequence ID" value="XP_050511275.1"/>
        <property type="gene ID" value="LOC126887674"/>
    </dbReference>
    <dbReference type="GeneID" id="126887674"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="372" mass="43343" checksum="52F81AA32BFC75EA" modified="2025-10-08" version="1">MEFKVEIKEELVEYNQKDLESQLSTSIDLENFKNELELEDNSEMGPKAEIKEEFAAECSQEYRENQLCTSQDLEDLVNKADEDNSGFCQNGMKIVKTELACSTEQQISATIEETPSKNSICKCKICFKQFNQAGSLKRYLKTHTAKKLNKCEICLKQFDRAHDFKCHLRVHTGETPYKCEICFKQFTIKRNLKTHLRVHTGEKPYKCEICFKQFSQANNLKSHLRVHTGETPYKCEICFKQLTTKGTLKTHLRMHTGETPYKCEICFKQFSQANSLKFHLRVHTDETPYKCEICFKQLTTQGSLKTHLRMHTGETSYKCEICFKQFSHAHSLKYHLRGHTGEKPHKCEICFKHFSRAHSLKSHLRVHTGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KML2</accession>
    <name>A0ABM5KML2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511408.1">
        <property type="nucleotide sequence ID" value="XM_050655451.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655451.1">
        <property type="protein sequence ID" value="XP_050511408.1"/>
        <property type="gene ID" value="LOC114324776"/>
    </dbReference>
    <dbReference type="GeneID" id="114324776"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF70">
        <property type="entry name" value="INHIBITORY POU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="243"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="307" mass="33449" checksum="AFEE134938992BCD" modified="2025-10-08" version="1">MCNSWSPRHNGDLFSGLNDGLISRAEALAAVDIKHQGTGGPGGLPQLKHDMMYHHSMGAPPPVSRPHHQMGHMDGLEMLDPISSSSMTTLTPMSETPTHMHSYGMNHVMNHHHHGGPLSGHSAPAHHPAMAAAAAAAAVAGLHPDADTDPRELEAFAERFKQRRIKLGVTQADVGKALANLKLPGVGALSQSTICRFESLTLSHNNMIALKPILQAWLEEAEAQAKNKRRDPDAPSVLPAGEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP92</accession>
    <name>A0ABM5KP92_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512009.1">
        <property type="nucleotide sequence ID" value="XM_050656052.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656052.1">
        <property type="protein sequence ID" value="XP_050512009.1"/>
        <property type="gene ID" value="LOC126888042"/>
    </dbReference>
    <dbReference type="GeneID" id="126888042"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="128" mass="14073" checksum="5A79445DB8798B2B" modified="2025-10-08" version="1">MFFKNQGENNAKPLLITHDDKEINASIDVASTSKPHLTEKDELSENSNNDSHLAASTSSGFLVSNDVSLWPTTLTDAFRASCVEKGSEYFQNNDGVYAASKRNFKTQNRSLSDVPDDAKLAKVYLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQS7</accession>
    <name>A0ABM5KQS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050512543.1">
        <property type="nucleotide sequence ID" value="XM_050656586.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656586.1">
        <property type="protein sequence ID" value="XP_050512543.1"/>
        <property type="gene ID" value="LOC114337893"/>
    </dbReference>
    <dbReference type="GeneID" id="114337893"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF244">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="407"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="524" mass="58074" checksum="38C8FE061FEE21B2" modified="2025-10-08" version="1">MPMILEAVVTMLACTRIGAVHSLVFAGFSADSFAERILDCEAKVLVTSDGAWRGEKLLQLKAICDQAMAKCAQKGHNVETCIVVSHLGRVTSPTGVQYSSNKTPMTPGRDIFWHDIVPQASTSCYPEWMESEDPLFMLYTSGSTGKPKGVLHTTGGYMIYAATTFKYVFDYKPNDIYWCTADIGWITGHTYVVYGPLANAATSVLYEGTPFYPDNDRFWVVVDKYKVTQFYTAPTAIRALMKFDDELVTKHDLSSLRVLGSVGEPINPEAWLWYYKLVGRGRCSIVDTFWQTETGGHVLTPLPGAIPMKPGSAAVPFFGVEPVLLDEAGKEIKGEGEGYLVFSRPWPSLMRTLFNNHDRYETTYFTKFPGYYCTGDGARRDADGYLWVTGRVDDMLNVSGHLMSTAEVESILTEHPSVAEAAVVARPHPVKGECLYCFVTLTEHGVFNDKLTKDLKQIVRSKIGPFAQPDIIQNAPALPKTRSGKIMRRILRKIAVNDRDVGDISTLADSSVVEVLFASRPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRW2</accession>
    <name>A0ABM5KRW2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512927.1">
        <property type="nucleotide sequence ID" value="XM_050656970.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656970.1">
        <property type="protein sequence ID" value="XP_050512927.1"/>
        <property type="gene ID" value="LOC126888613"/>
    </dbReference>
    <dbReference type="GeneID" id="126888613"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="711" mass="80297" checksum="CAA4769796D16093" modified="2025-10-08" version="1">MDEATARSKKKPGKSNITRVETWIRDHLDQINSKFAIAVKLDMLKEAFHNFNDGYNYLEGTLPDGRKLETREETDALYLGCFDILSTKLDLLSKDSLDLESVSTSSTKNVSPVAVRLPEFSIQPYSGKIMEWDSFFQIFDITILKNDSLSDIQKLMYLKSYVRGEPAKLISNFPVVAKNLKLVLDTLVERYGNKYNLTKTLFLKLLDFKPVPQNANHIQLRDLYVHWSNKLKALDNLNITDKDKLDWILILLVEQKLDSATLRSLEFSREQKVEVTFEKFLNKIQKRATHLENLVPIKHSDASTSNKNKSAAPTYNRMNNRVLSATDSGKISCNFCSLQNHLICDCRKFKKMSVSDRFKFVKTNKLCVNCLEGEHYVLACPSKKSCVVCQKNHATLLHFSKRSLSPCSQLQTTETLNSSPSLPNDKNVSNGNNASIEFTTLTMSNKNSVVLLGTINVFLYSKYGRKISVKALIDTGSQLSFITEELANRLKYPMQEKNMSIYGLGISLTRSQKTVNIVINSSVNSEKMRMSCGILSKITNPLPQFKIDSKKLCIPSHFVLADSQYYVTSDIHLLIGADYCYKLLVDGMHHMGENMPTLQNSRMGWIIAGTIPTSFIKNPSSKNSHAPHACFGTKQLESIHTSEDASPCVSLCISSGNSETLEHIVQKFWCTEDVPREKPSLNSDELIAEKIFVDSTVVLPDGRYQVDMPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSJ9</accession>
    <name>A0ABM5KSJ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131754.2">
        <property type="nucleotide sequence ID" value="XM_028275953.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131755.2">
        <property type="nucleotide sequence ID" value="XM_028275954.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513164.1">
        <property type="nucleotide sequence ID" value="XM_050657207.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275953.2">
        <property type="protein sequence ID" value="XP_028131754.2"/>
        <property type="gene ID" value="LOC114327363"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275954.2">
        <property type="protein sequence ID" value="XP_028131755.2"/>
        <property type="gene ID" value="LOC114327363"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657207.1">
        <property type="protein sequence ID" value="XP_050513164.1"/>
        <property type="gene ID" value="LOC114327363"/>
    </dbReference>
    <dbReference type="GeneID" id="114327363"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="625"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="735"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="804" mass="89711" checksum="006F95B3308DECA3" modified="2025-10-08" version="1">MDIRDIPSTSSCDPLFEDEIDQRTIPPPKVKRFTNVMSINNADSDSEEDTREIVVNYTGSCPLISSQRRRVETSKEKVQTGSLNVLSAKYESLDYDTCENHLLLDEERKKGYKFIVQKSIARWFIFLLIGMCTALIACVIDISIEELSTIKYASLSKSVDKYVTEGELYKPYGLWILYNIVPVLIGSILVAYGEPIAAGSGIPQVKCYLNGVMVPRVVRVKTLVVKSIGVICSVVGGLAGGKEGPMIHSGAVVAAGISQGKTSTFNKDFKVFKYFREDHEKRDFVSGGAAAGVSAAFGAPVGGVLFSLEEGTSFWNQSLTWRTFFASVVSTFTLNVVLSAYHGAPGNFNYPGLLNLGKFEAFSYEYYELPIFLIMGSLGGLFGALWNHINYKITVFRMRYIRPRWMKVIEACIVAAVSATVGFLMMFTINDCKPLGSDPTRYPTQLYCLDGQYNVLASIWFQTPEASVRSLFHDPPNTHNAISLASFVIIYFFLACWTFGLSTSNGLFIPTLLTGAAWGRLVSIGIYYVFPNVGLIHPGKYALIGAAAQLGGVVRMTISLTVIIMETTGNISFALPLIITLIAAKWTGDFFNEGIYDILIQLWGIPLLPWEPPPLVHNIYASEVMSHPVVTLKCVENVGHVVELLKLTTYNGFPVVDPPLTDQNEVTTYGRIRGIILRSQLVVILQKKIFNETVDVWYNINPSLFRDSYPRYPTIEDLELTDDEKTCSMDLRPFMNPSPYTVLHSSSLPRMFRLFRGLGLRHLPIVNDTNEVVGMVTRKDLARYRVWRHRGHMGVEELFISKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT12</accession>
    <name>A0ABM5KT12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maestro heat-like repeat-containing protein family member 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513316.1">
        <property type="nucleotide sequence ID" value="XM_050657359.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657359.1">
        <property type="protein sequence ID" value="XP_050513316.1"/>
        <property type="gene ID" value="LOC126889255"/>
    </dbReference>
    <dbReference type="GeneID" id="126889255"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="4">
        <location>
            <begin position="39"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="3">
        <location>
            <begin position="262"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="2">
        <location>
            <begin position="941"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1648" mass="186183" checksum="B850F3DBC2FF8B59" modified="2025-10-08" version="1">MTTNGKINAETQLQVTIGRLLQSVTDKSYLVLESVKCSLKKLAEKHPNQVLNSCCQFITKSPKPPPEHVSSILYIMELVCSDHILKINGDTIIQTINVSLSIMTENISWDSQLQRPASGILVALGREHYVQVMDALREKLQPSVIPHHMVPYTLGALASANAIGVVPYLKDIYSIILPLLPSLRTEILKQSVSFALGNFCEALTEYISNSEKVPDPTISLETFSEEISIAYNILFSNWINSRDAKTNECVLEAITLIYPVLSENIAQQTPKTIQVLLNLYKRNVNTYSITKCLGSVIKKSASMNGMLLEPMLPNILSTLFDLLNISPDYAQPSFLKSHSEVLRCYECFVLHFTDNTMDQLLSQLKNNNDKEKVKSLIVITHLISYSGDQAIKGRYKDIVKHVNDVLNDNNLRVKTALVKIIVALCCKKVLLDKEINPDGPEKYIEFILKMCCKQVLPKSIILDPQELDNIQKSTDNTLYMLSTSVPELESVLWNLLLKCFLNPTYDDAIVVILRCLTHLASKRDKVESCETAFVRALSLLARPLPNFRGCFILNFLKNIKPCSVESYKVVWDGKIPQLLKYLEQNLENFNVIEWHDLVFDFLNILLETTSNESFNEMIVVNAKKQLEMYSNTRYVASQNGDYQIKQSEKQFLLKCLAIALCYLRDKESVMQTLDSILNNVKLTDYAESQTCAEAVGICSRTHLQLVLEKLATIRKEVLTKKSSKFLNFLKDQKHEVALDRLRYTVLCSYAQVCNEAPSHELLQVIQSEILEYAVGELVNSKDFPIRKICLKTIQAAADAMHPNRNSLHVKMNDRDNIIRLVSSHIHLHSGPEYIELFPLIIPTVTALVRLPVPIESEDRIKLLKLFFDNVYNAATVYCKINPDNTDKYYGELKLVPHVTKSFTELNQLVKDLLLQNLSPATLDEIVTLLEPWLSKKRQEQRLPAAETLRLVLQTYLDNMKFAYECPTTFGQTGFLLAKVVPRCTDLNKNIRKVSVECLCIILCIAARYEGHMRDHDKVLSNSLQHIHQQIDSDEPKLLYNLTSDLAHIICVNLPSFQLIHCIDGLTDALLDCESSSSNGSSVVLNVILKNKGGELSSHVVHVIEKLLKQLYQIRCPRTKSSTYRAVLNLAMHHSKTVCGILLNQPLPFDNAICECWSIISIDLTLAADLIDQLKKAIKSTPLYEDQSNGNVRIANLQPLQAVCALHELLKNSHLKDICLQQFPELFTILLTCVSCYMGAISPAIKKIDSAREKYGFSLNRDAYKMLPAKVAIETLRSFLLCCEFEKMAASLLLINNTDAFEDVNLFLKVIQSLVENVCEEHPQSLSWLVASLGPYIRADLDPQRVVTVAFFSHLLQQSHTEQNVLTENLLEMILDVQGDSCSLVKRLGLQGLGYAAEHLSYELVSRHCNPILSVLMNSLDYHNIGMESAVILEGMLSFSKLLDAMEGCKFSSFQVTAAVRIKPLLDQEDVNLRRAAFRLLGDLTQSLNSEGNLEAFKEQIHGNIVTLLLHLSDPDIYVVKACKYTLRKIGPYLGSSKVNSMIQEHLIDEANLHFTDFIRDIIKLMTEDLQDLFPLLIMTCLSYFKSQWEEIKGNAALIAGLLYSQLVPENKSRVSLDTVCDRLLRLMDDEDEEVRVKAVEAVSYLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWA1</accession>
    <name>A0ABM5KWA1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050514468.1">
        <property type="nucleotide sequence ID" value="XM_050658511.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658511.1">
        <property type="protein sequence ID" value="XP_050514468.1"/>
        <property type="gene ID" value="LOC126889827"/>
    </dbReference>
    <dbReference type="GeneID" id="126889827"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="846" mass="95358" checksum="A5A2799CCE5B1404" modified="2025-10-08" version="1">MRALSETPTMQHVFSKEDWALLDAMTTVPVPVCHGKFLTMHKRRRKKLTTRSLSQDHAILDDIHHGQVQKILDRCTKWAFNAFTLETVAGGKSLPVLCVHLFHWYGLLDYFHLEVVRVWKLFTLIEEGYHSTNPYHNSIHATDVTQAMHCFLQETRIRRHITPLEIMASLIGAVAHDLDHPGVNQHFLISTSNHLAILYQNKSVLENHHWRSAVGCLLESGVAEQLTPYRSELEQQIRDLILATDINRQNEFLTQFKKHLDEDTLDLREAHHRQFIMQIALKCADISNPTRPWDISKKWSSKVCDEFFRQGEFERKLNLPVTSICDQQSTSVAKIQVGFFKNVVTPLFAEWHRFMSSNLSTHMMNILDTNRKRWEAQEKAEQAEETQTELSDAEPEIASDDEEELLTTKSSTSRCTQEYASHAPRDIGRQSLTVPTLESLEVRRHSVPVNMEHTLPRPIYRRESLPTGKGILLNRTPVSPQTESRASSGLKEEDELLPPYGSQSDMSSSPPYSSEQPERPLSAENLLPEPTIASMTSSTAVSRLTSILQGNVVVPNKLLTRQQTFPPPQPYIRMRYMSATAEMSTCAEIPSEGGSGSSSSHSSPENISNLSNIPQNIPTIAVLSPNNSRSPDFLDLSPPDSSKNKSSCSYKKDTDVIDKEKNGKMVVISEVGQKREKENLDPKRLGSAHLNKRRGSAPVMPTLPKPDEKISPASRGLVVSDTDSLRRGSVPIEVAQYHIIEKKNLHQLQFPRRGSAPTNIISIFGGNGEKLEQLTRHTSLNGKAGRRKKLKRRISGGPETFCQADTFSEATSRLFLLRKPEDTEALLVQRRGSLPVEVLSFGHSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWH3</accession>
    <name>A0ABM5KWH3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514541.1">
        <property type="nucleotide sequence ID" value="XM_050658584.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658584.1">
        <property type="protein sequence ID" value="XP_050514541.1"/>
        <property type="gene ID" value="LOC114342607"/>
    </dbReference>
    <dbReference type="GeneID" id="114342607"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="3">
        <location>
            <begin position="558"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2153" mass="236852" checksum="FE70FA1C3C6D6DF8" modified="2025-10-08" version="1">MKPITFENLRRLVGGGRKKKEKESSFKRSESFKRISIRRSYLDRGKKKHVHKLEVSTQTVTEEEEILETAKETPGSVQVEKRDVAVATNDLTIKNEVKCNNKYKLEQSKSGPGQSVIAYGQWLRGIRKTESSNSTGIKGSERTIIYVPASDEIVPPPVIRQLSSSPVLIKKSPIQKRKSKQRSPSLQRKESNDSAVEMFPWGDSTELKKSPLVRRRSRQSPLPLLPDSGAEEMCSLSISLGRIWIDAPTGMAPRSLELPKSTGPPAPAHHSLDSALKDLRDDPIVINRLQKKPTPPVGRTLSSTSNTTASTGLFSSKDSGFSFSISAPKLNDFHSNFASPPSRGLFRKKRPKPKLSVSRDGYFKRTSGALVVDTKRSSVTRKHSGRKKNKKKKSVKESGSVRSDLYQVMVSRPSKSLRSLKLDPMIFVPPEKRKSCINRKSSFKYGLSEIRNWTPLDNSIYVSRSTYSTDEGLYESLTGDYEYLSDELSCNISRLTLTNDEYENFACGSPVSDKSTISLLVSDSSKSDNPYVPPGVSPVPKRKPVRQKKTGLSHKRSITYVVKPTIIRAPSTLRRQNKKGDITQKGYEKKRTRLLTPYIPKHNPTGSGGTEGGTGDIGSGDSSGVAGIAGNGKHHTRRRTQRRVTHNEKRYHSEVRQEAVQQALAQALQNRHKPSMPMPSKRTSVMARSPDRDRHDSESSSDEDSIVNEETIESTPERERVKDRSTPQMFPPPPLSDTSSTGSPPPLHHRPRLPPPNNWEDKRRIEITEISDVLQNFRPYSQPPDVTHNTAQGGRRPAADRVNRYGSSGSDDTGTGTGRWKVSTKIQQLLNTLKRPKRRPLPEFYEDDDIELEIAANPKDPNAPKPEGSCMSPAVGEQLVIPSGLPRSLEAAISRYGNGTFKAPVATVLDPNGKLSVTLTYGKLFSRSHKIAYALLTKSFSKNGDTSLKCGDRVALVYPNNDPINFLCAFYGCLQAGIVPVPIEVPITRRDAGSLQIGFLLGSCAVQVALTSEACLKGLPKTTSGEVIQFKGWPKLTWFVTEHLAKTPKDWSPTPRLTDETPAYIEYSTDRDGSVMGVTITRTAMVQHCRMLTMSCNYTEGENMVCVLDFKREVGLWHSVLTSVLNGMHVIYIPYALMKVNPASWMQMITKHRASVAVVKSRDLHWGLLATKDHKDVNLGSLRMLLVADGANPWSLSSCDQFLSVFQTKGLRADAICPCASSSEVLTVSVRRPGRGGVNATGRGVLSMQGLSYGVVRVDQENSLTSLTLQDCGQVMPGCVIVVVKMEGLSYLCKTDEVGEICVNSGATGTQYWGLQGLSNNTFKVQPLGVDGKPISDAEYTRSGLLGFLGPGGLVFVCGSRDGLMTVTGRKHNVDDIIATVLAVEPMKFIYRGRIAVFSIKVLRDERICVIAEQRPDCSEEESFQWMSRVLQAVDSIHQVGLYCLALVPPNYLPKTPLGGIHLSETKRRFMDGNLHPANVLMCPHTCVTNLPKPREVHSDVGPASVIVGNLVQGNRLASAQGREVGGLLDEEGDSSKKQQFIAEILRWRAQCTSDHILFTLLNSKGAVAKVLSCSELHKKAERIGNLLVEKGKVNTGDHVALIFPPGLDLICAFYGCLYVGAVPVTIRPPHPQNLQTTLPTVRMIVDVSKSVLVLSIQAVIKLLRSKEASNVVDIKSWPLILDTDDMPKKKLPVPYRAPTAEMMAYLDFSVSTTGMLAGIKMSHAAVTNLCKSMKLACELYPSRHIALCLDPYCGLGFALWCLSSIYSGHHSILIPPSEVEINPALWLTAVSQYKVRDTFCSYGVMELCTKGLGSSVNQLKSRGINLACVRTCVVVAEERPRINLTTSFSKLFSALGLSPRAVSTSFGCRVNVAICLQGASSPEPSTVYVDLRALRNDRVSLVERGSPHSLCLMESGKLLPGVKVIIANPESKGQCGDSHLGEIWVQSGHNASGYFTIYGDESEYGDHFNAHLVTGNTGEVYARTGYLGFLRRTEMSENAVTDETIISRESDNESLGSSHHVVPTDSPELHDAVFVVGALDETIMLRGMRYHPIDIENSVLRCHKKIAECAVFTWTNLLVVVVELDGNESEALDLVPLVTNTVLEEHHLIVGVVVVVDPGVVPINSRGEKQRMHLRDGFLADQLDPIYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY70</accession>
    <name>A0ABM5KY70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515139.1">
        <property type="nucleotide sequence ID" value="XM_050659182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659182.1">
        <property type="protein sequence ID" value="XP_050515139.1"/>
        <property type="gene ID" value="LOC114332169"/>
    </dbReference>
    <dbReference type="GeneID" id="114332169"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF12">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="235" mass="26252" checksum="05AC3A129C956BDD" modified="2025-10-08" version="1">MSGFFCPKWCEEWVVLYEDSTLAWYSDKGLNRPKGCVRISDAPELLAVGEWTRQVPRRPKFPHACHMGQLLAIGSRKLHDVHWLMAKSPAEINDWMTAISNTLPPPPHLPLNDKRLSLTPQQKQDIVVSKQCQCNGVSSIANGNSIQQQTINSPLQKNYEADHTVLAGVCIDWGHGWGWGQNANWGPQALFGHEETLTVSQILPAASISYCHSAEDYTVSGMDEVDWCAFGDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYW2</accession>
    <name>A0ABM5KYW2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515378.1">
        <property type="nucleotide sequence ID" value="XM_050659421.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659421.1">
        <property type="protein sequence ID" value="XP_050515378.1"/>
        <property type="gene ID" value="LOC114333907"/>
    </dbReference>
    <dbReference type="GeneID" id="114333907"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="361" mass="36178" checksum="B7FC8A9DF08B100D" modified="2025-10-08" version="1">MACGYNSKSKNRKSLLDDLKALVCKLDGCSPSCAPCGPCGPCGPCVPSPACCPGTCPPATQAVPVGCCGPVCIPPACVPPVLPICTPVPPANVPLCNPNQGPQPCVPCNPPQMMVAYRMPKCIPCTRSKSRELRASILYIGCDCERKNGLQDDCPRVECQGAPCCVNCPEPRCGPSAFANGKHLGKSVCGMEDLEKYQCYPAFVRLPPCPPCGPCAPCGPSPPCGPCAPCGPCPPCGPCAPCGPCAPCGPCAPCCPPCSPCPPCPPPQVPLVAAAPPPPCCPPPCPPPVPVGKVCPVSPAVPIPACPPPAPCAPFAPCIPPFACPSGPCAPCGPCAPCGPCAPCGPCAPFACPSPCLPCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ10</accession>
    <name>A0ABM5KZ10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515422.1">
        <property type="nucleotide sequence ID" value="XM_050659465.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659465.1">
        <property type="protein sequence ID" value="XP_050515422.1"/>
        <property type="gene ID" value="LOC126890483"/>
    </dbReference>
    <dbReference type="GeneID" id="126890483"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06707">
        <property type="entry name" value="PDZ_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF1">
        <property type="entry name" value="GH21964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="113"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="314" mass="34640" checksum="F909D9095C697B07" modified="2025-10-08" version="1">MFKRQRSKNSGSPLQNGESQHSHMENSVPVSPVSKNTLQFYCQLAHGSPTAFVSGFSNVRELYGKIGECFEMSPSEILFCTLNTYKVDMKKLLGGQIGLEDFIFAHKKGRPKEVELTKSEDALGLTITDNGAGYAFIKRIKEGSVVSHIPHIQVGDHIEKLDNQDMIGKRHFEVAKALKEIPRGATFTIRLVEPLQSGFASISPKTGKVNGSKKGYGSGKETLRFKAGGKAEIQQQDSIMDAGVEKINNILESFMGINDSELATQIWELSVGKQNSMDFAESVDESDLATFEFTDEIIIELWGAITDARDGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1C0</accession>
    <name>A0ABM5L1C0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516229.1">
        <property type="nucleotide sequence ID" value="XM_050660272.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660272.1">
        <property type="protein sequence ID" value="XP_050516229.1"/>
        <property type="gene ID" value="LOC126891094"/>
    </dbReference>
    <dbReference type="GeneID" id="126891094"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23377" checksum="B6370EA24646EF66" modified="2025-10-08" version="1">MNTEMFVRWLSEKLLPGFSEPSVIILDNAPYHSEILNKSPTNSWNVDQIKEWLTNERISIPQHILKSELLRFTKEHAKPKIFMVDLVIESYGHQVLRLPPYHCQFNPIKYIWGTAKQYYYNHIGPNGYTDEAVWETWREALSIATPEVWRNCISKLEKLIEDWWIRENKINEISPIIITINGDESDDDGSDGDDSGNNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L265</accession>
    <name>A0ABM5L265_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516536.1">
        <property type="nucleotide sequence ID" value="XM_050660579.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660579.1">
        <property type="protein sequence ID" value="XP_050516536.1"/>
        <property type="gene ID" value="LOC126891406"/>
    </dbReference>
    <dbReference type="GeneID" id="126891406"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="178" mass="19631" checksum="C811C4039F10B5B6" modified="2025-10-08" version="1">MQEYNFQTISEMKTKIKRRVREVRYGYQGTGGGGGIKPLTPVEERLLALLVSEVSIEGAQLAKAGVEMIDESFETPIDIEIIEVEQQPSTSPLHHVPPPRPSSTESTITNPVTQPQPKKAKTVGTSARRGSRRTPPRGRNRVSSAMEVHYRQLANLAMSNYAIASAINRLARAIAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L417</accession>
    <name>A0ABM5L417_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517187.1">
        <property type="nucleotide sequence ID" value="XM_050661230.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661230.1">
        <property type="protein sequence ID" value="XP_050517187.1"/>
        <property type="gene ID" value="LOC126891886"/>
    </dbReference>
    <dbReference type="GeneID" id="126891886"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60920" checksum="42C34471673D6DC4" modified="2025-10-08" version="1">MPMKASDFRQLYRKRDIIEQRFNNFIKFIESMTNIAINDLSEDHFSQIEWNTERTESLVTEFDEIQMSIELNCQDQDIQQEYAKRQRLDTIFSKTLSKARTILKRKCSDSSSSESKRLDINHEYSGLEGVKLPPIQLPVFHGDYLTWIEFKDTFEGLIHNNKVLADIQKYHYLRASLKGDALKIIQSLDFSAQNYNSAWQTLCNRFDNSRMLVNNHLKALFEIENLNKESALGLRSMIDSVKKHLFALKSLQLPTEHWDAIMVYLVSGKLDKFSSREWEKRKIDNFLPSLNEFLEFLKNRADFLETIELSNVTKPDYKSNYQDKRSRSLLTSKSRSCNFCKQNHLIYLCEEFLKLSVAQRWDKIKQLNLCRNCLCTGHSYKQCKSFGCKICKAKHSSLLHENKPSDIHVKDNSSINFNPNNDSENEPNKVKLSTNTSENNVNRNEIVLKNNCSNNDYVLLSTAKVRVYDRYGNTHIARVILDSGSQSCFITEDFLMFLINLGDLCLNGLGAVQGGEYGRKIFIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5G5</accession>
    <name>A0ABM5L5G5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517682.1">
        <property type="nucleotide sequence ID" value="XM_050661725.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661725.1">
        <property type="protein sequence ID" value="XP_050517682.1"/>
        <property type="gene ID" value="LOC126892222"/>
    </dbReference>
    <dbReference type="GeneID" id="126892222"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18976" checksum="8AC71CF66E772F1E" modified="2025-10-08" version="1">MSVIPSQLVILTGDPVNSPIHTALIIMRELFVFGVKDISLKKDRIFVMLSYTPNSKHLKRKIVNLPIRYMRTKIQSEEEFQKVEEAVKRYRFNLLDEEYEDFEKQQQIQTTSGIKRTLYIQGTDQLAGKKSKPSTSTSSTPVVELNDHDYEDIEHFLTQRTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5L6</accession>
    <name>A0ABM5L5L6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517729.1">
        <property type="nucleotide sequence ID" value="XM_050661772.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661772.1">
        <property type="protein sequence ID" value="XP_050517729.1"/>
        <property type="gene ID" value="LOC126892260"/>
    </dbReference>
    <dbReference type="GeneID" id="126892260"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="426" mass="50059" checksum="BB6CDD64B5122B06" modified="2025-10-08" version="1">MEVKQEITEETCKIEIEYNHLDDALLDSFKCEVQDESNHQDTCDSVDLKKCPMNNEIEQHGNKLNPFEEDQITEKGYPQDENKTEITEKLVEYSSYKGNDMNRHTEGKLSNRNMKVATEKRLYKCEICSKKFSHKCFLKIHMRAHTGEKPYKCEICFKKFSTAGYLKTHLRLHTGEKPYKCKICFKQFMTAGNLKTHLRVHTGEKPHQCEICFKQFSTAGSLKEHLRVHTGEKPHKCEICLKRFIRTGHLKAHLIVHTGEKPHKCEICFKQLSTARYLKEHLRVHTGEKPHKCEICLKRFIRTSHLKAHLRVHTGEELHKCEICFKQFSEAGKLKRHLTVHTGDKPHKCELCFKQFNQACDLKVHLRTHTGEKPYKCEICFKPFSEATNLKKHLRVHTGEKPHKCEICFKHFSQKIHLKLHLRLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAZ7</accession>
    <name>A0ABM5LAZ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="10">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050519616.1">
        <property type="nucleotide sequence ID" value="XM_050663659.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663659.1">
        <property type="protein sequence ID" value="XP_050519616.1"/>
        <property type="gene ID" value="LOC126893451"/>
    </dbReference>
    <dbReference type="GeneID" id="126893451"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="334" mass="36476" checksum="44ECB0A33C812292" modified="2025-10-08" version="1">MILLTILIVSGIAFIIFALAVQPLRKKSINGKHVVVIGGSSGIGKSVAKLAAREGAHVTIIARNVDRLEEAKQEIQQHVVDANQQIISRVSVDVADYASLDNNITQIEDQVGPIYMMVNCAGMAICGVIEDLTLQEIKQLIDVNYLGSIYSVKSILPRLKERKDGIVVLTGSQASLMGIYGFSIYSGCKFAVRGLAEAVHMEAKPYNVSVTLALPPDTDTPGFANENKNKPEETRIISEAGGLANPDDVAKRLLDDALVGKFFSYYGFESSVLTTLCVGMTPPLRCIEVIVQTLVLGPLRLLGCYYVTTFHKVVQNCYNDKKNRELEQDTQKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F128</accession>
    <name>A0A6P7F128_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114324871</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128567.1">
        <property type="nucleotide sequence ID" value="XM_028272766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F128"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642256.1">
        <property type="protein sequence ID" value="XP_050498213.1"/>
        <property type="gene ID" value="LOC126879203"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7F128"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028128567.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52720" checksum="B66E8A131B68A032" modified="2020-12-02" version="1">METNLLNGRKIEKEKSWPQVLAILIGAISGFCVGLLFAWSSPFLIKITQDKTNYNITEDEASYFNVIQPVSMIFSCPIFSTLTDIIGRKRTLLLIIIPHICSWLCSGFAKSVYVFYLSRVCAGFADGCIFASLPTYVGEVANPSVRGTWGNAVSFSLYFGEFMITVIGSYVSVRKASYIGIPICLLFFSLFSFMPESPYFYIKKGQEDDAKKSLRFLKGKSDVEEDYICLKKDVERQLSESASWIDIVKIRSNRKAILAGIFIRFTQQTAGLNVFYIYTQFIFRQGGGNISHEHASMLLLGVSLILNIIALTFIVKRFGRRGCYLWSLIGTGILLYIMGIYYYLKDNTTLNLLSFKWMPIATMMGYQVFASFGIATIPTLMLSELFSASVKSKAMAILTMTFGLGNFLNNFIFYELNRRIGFYAPFFFFAICNTIAAVMCLFVVPETKGKTLEEIQQELKGSRIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1B8</accession>
    <name>A0A6P7F1B8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional activator protein Pur-alpha isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114325293</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PUR DNA-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129116.1">
        <property type="nucleotide sequence ID" value="XM_028273315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1B8"/>
    <dbReference type="FunCoup" id="A0A6P7F1B8">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273315.1">
        <property type="protein sequence ID" value="XP_028129116.1"/>
        <property type="gene ID" value="LOC114325293"/>
    </dbReference>
    <dbReference type="GeneID" id="114325293"/>
    <dbReference type="KEGG" id="dvv:114325293"/>
    <dbReference type="CTD" id="43797"/>
    <dbReference type="InParanoid" id="A0A6P7F1B8"/>
    <dbReference type="OrthoDB" id="523901at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2450.30:FF:000001">
        <property type="entry name" value="Purine-rich element binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.700:FF:000004">
        <property type="entry name" value="Transcriptional activator protein Pur-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2450.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611">
        <property type="entry name" value="PUR-TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12611:SF0">
        <property type="entry name" value="PURINE-RICH BINDING PROTEIN-ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04845">
        <property type="entry name" value="PurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028129116.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31735" checksum="466380548B88889F" modified="2020-12-02" version="1">MSDIGSGDEGSSSQKYHQGMEQGSEYDSGQQQVEQELATKMLQIQSKRFYLDVKQNRRGRFIKVAEIGADGRRSQIFLALSTAAEFRDHLSAFSDFYSSLGPPNPDNVPEDGKLKSEMMIKDNRRYYLDLKENSRGRFLRVSQMITRGGPRSQVAIPAQGMIEFRDALTDLLDEFSTDEHSYKPDLPEGRHMHVDNKNFYFDIGQNNRGVYMRISEVKTNFRTAITVPEKSWQRFRDILSDYCDKIKQPSQGSGGGVASQDQPHPLVGNNTQQDSGTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1D6</accession>
    <name>A0A6P7F1D6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exosome complex component RRP46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114325304</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129136.1">
        <property type="nucleotide sequence ID" value="XM_028273335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1D6"/>
    <dbReference type="FunCoup" id="A0A6P7F1D6">
        <property type="interactions" value="609"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273335.2">
        <property type="protein sequence ID" value="XP_028129136.1"/>
        <property type="gene ID" value="LOC114325304"/>
    </dbReference>
    <dbReference type="GeneID" id="114325304"/>
    <dbReference type="KEGG" id="dvv:114325304"/>
    <dbReference type="CTD" id="41270"/>
    <dbReference type="InParanoid" id="A0A6P7F1D6"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028129136.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22852" checksum="19E716A4830EF902" modified="2020-12-02" version="1">MAKTTEKLKYSCKLGLLTRPDGSAVLSEGNTTVIAGVYGPVEVKLQKLLLDKASVECHYKPKSGLPGVEDRLYESLIRNVCETALCASLYPRTSILIAIQEIQNSGQLVSCAINAACLACLNAGIDMKFMFAAITCYLNTDDELTLSPPISEKDIKSQFLFAFDSCEGRILASHTKGSFSEDQFDEALRLSKEGSENVFNFFRSALNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1S8</accession>
    <name>A0A6P7F1S8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock 70 kDa protein cognate 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114325093</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128832.1">
        <property type="nucleotide sequence ID" value="XM_028273031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1S8"/>
    <dbReference type="FunCoup" id="A0A6P7F1S8">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273031.2">
        <property type="protein sequence ID" value="XP_028128832.1"/>
        <property type="gene ID" value="LOC114325093"/>
    </dbReference>
    <dbReference type="GeneID" id="114325093"/>
    <dbReference type="KEGG" id="dvv:114325093"/>
    <dbReference type="CTD" id="41609"/>
    <dbReference type="InParanoid" id="A0A6P7F1S8"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028128832.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="69615" checksum="15FDBFBC04D063AC" modified="2020-12-02" version="1">MGKVAAIGIDLGTTYSCVGVWQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNTVFDAKRLIGRKFDDPKIQADMKHWTFNVVNDCGKPKIQVEYKGEVKTFAPEEVSSMVLTKMKEIAETYLGGKVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLKGEKNVLIFDLGGGTFDVSILAIDEGSLFEVKSTAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDLSNNTRALRRLRTACERAKRTLSSSTEASIEIDALHEGVDFYSKVTRARFEELCMDLFRSTLQPVEKSLTDAKLDKGAIHDVVLVGGSTRIPKIQKMLQDFFCGKALNLSINPDEAVAYGAAVQAAILSGDTSSQIQDVLLVDVAPLSLGIETAGGVMTKIVERNSRIPCKQQQTFTTYADNQNAVTIQVFEGERAMTKDNNLLGTFNLAGIPPAPRGIPKIEVTFDLDANGILNVSARDSSTGKQEKITITNDKGRLSKAEIDKMLSDAEKYAAEDEKQREKIVARNQLEGYIFSAKQAVEDAPADKLSAEDKKLVQDKCSAVLSWLDANQLAEKDEFEHKMKELQQECSPIMMKLHQGGQQGGQQGGQAGQGGQGGPKVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1U6</accession>
    <name>A0A6P7F1U6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114325672</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129594.1">
        <property type="nucleotide sequence ID" value="XM_028273793.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273793.2">
        <property type="protein sequence ID" value="XP_028129594.1"/>
        <property type="gene ID" value="LOC114325672"/>
    </dbReference>
    <dbReference type="GeneID" id="114325672"/>
    <dbReference type="KEGG" id="dvv:114325672"/>
    <dbReference type="CTD" id="33768"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000329">
        <property type="entry name" value="No mechanoreceptor potential C, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1290"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1321"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1351"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1391"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1429"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1520"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="678"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="848"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1029"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="1350"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1703"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1713"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028129594.1"/>
        </source>
    </evidence>
    <sequence length="1725" mass="188911" checksum="B3BED1F340BB5CF4" modified="2020-12-02" version="1">MSQSGGKRGGGKGPPKDKNEDGKEKDKPGNVKEPKEKEKDETTSNPEGEEGTVSKPQSAGANIRDAAQRILVLCQKGEWGPVEQILKSMEKAIANAGEDANSVPLAGVLDLVTGMTPLMYAVKDNRTSLVDRMIELGSDVGARNNDNYNVLHISAMHSREDVVKLLLSKRGVDPYSTGGSRNQTAVHLVASRQTGTATAILRALLQAAGKEIRLKADGRGKIPLLLAVEAGNQSMCRELLSAQTAEQLKAQSANGDTALHLAVRRKDIDMVRILVDYGTSVDIRNGEGQTPLHIAAAEGDEVLVKYFYGVRASASVTDNQDRTPMHLAAENGHANIIELLADKFKASILERTKDGSTLMHIASLNGHADCAMMLFKKGVYLHMPNKDGARSIHTAARYGHVGIINTLLQKGEKVDVTTNDNYTALHIAVESCKPLVVETLLGYGADVHVRGGKLKETALHIAARVKDGEKCALMLLKSGAGPNIATHDGNTPVHVAAKYGNLQTLLLLLEDGGDPQFKNKKGETPLHLAARGCKAEVVQLLIAYVKDHKSEEKAAAYINETNENDESALHYICTVTKEEVEVPNSDREVAKILLENGADVKLLTKQHESAFHYVALAGNNDVVMEMISHMSPTDSQKALNRQNDHGWTPLLIASRKGHIDLVNNLLANHARVDVFDLEGRSALHLAAEQGYLQVCDSLLTHKAFINSKSRNGRTALHLAAMNGYIHLVKFLIKDHNAVIDILTLKKQTPLHLAAAAGQIEVCKLLLELGADIDATDEQGQKPIHAACQNNYSEVAKLFLQQHPSLVMATTKDGNTCAHIAAAQGSVTVIEELMKFDRQGVISARNKLTDSTPLQMAAEGGHAEVVKALVRAGANITDENKGGFTAVHLAAQYGHLQVLEVLRSSNTLRITSKKLGVTPLHVAAYFGQADTVRELLTHVPGTVKSDSPNGASLVPALGNESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATHENGYNPMHLACYGGHGTVVGLLLSRSAELLQSHDKHGKTGLHIAAQHGHLQMVEVLLGQGAEINSQDKNGWTPLHYAARAGHVDVVKLLVESGASPKAETSLGAVPIWFAASEGHHAVLEYLMTKEHDTYALMEDRRFVYNLMVCSKNHNNKPIEEFILVSPAPVDTAAKLSNILIVLSNKEKERAKDLIAAGKYCEAMATELLALAAGADSAGKILTATDRRNVEFLDVLIENEQKEVIAHTVVQRYLQELWRGALNWAAWRTLLLFVFFIICPPVWIAFTLPLGHKYYKVPIIKFMSYLTSHVYLMAFLLIVGITPPYPVLRKSLLPYSYEWILLVWLSGLLLFELTNPSDKSGLGWIKISVLLFSIFGVGVHLLAFVLDDKAHWPTMLYCRNQLFALSFVLACVQILDFLSFHHLFGPWAIIIGNLMKDLARFLAVLAIFVFGFSMQFVALNQPFANLTPSELIRLNRQGVIKTGYFTDVQKNPISAFELLFFAVFGQTSTEQLKSYGPNAANRSNNQPPWTEVLFKLVFGVYMLVSVVVLINLLIAMMTDTYQRIQAQSDIEWKFGLSKLIRSMHRTTTAPSPINLITTWLFYLVDVCKKRDFIPVKQRKRQSLVHLMGTFQRSSQLSPRSKAGAKWLSKVKKGRQIAPKESVALSVAHLSPLGSQLSFSMQTTRIEHVADWEAIAKKYRALMGEVDETKDKSKDNEEEETEEETPTGNAIPVQNSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3Q4</accession>
    <name>A0A6P7F3Q4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114324814</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128483.1">
        <property type="nucleotide sequence ID" value="XM_028272682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3Q4"/>
    <dbReference type="FunCoup" id="A0A6P7F3Q4">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272682.1">
        <property type="protein sequence ID" value="XP_028128483.1"/>
        <property type="gene ID" value="LOC114324814"/>
    </dbReference>
    <dbReference type="GeneID" id="114324814"/>
    <dbReference type="KEGG" id="dvv:114324814"/>
    <dbReference type="CTD" id="6222"/>
    <dbReference type="InParanoid" id="A0A6P7F3Q4"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 12" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028128483.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17619" checksum="ECE2683179DE1981" modified="2020-12-02" version="1">MSLVIPEKFQHILRILGTNIDGKRKVQFALTAIKGVGRRYANIVLKKADVNLDKRAGECSDEEVEKIITIMSNPRQYKIPDWFLNRQKDIIDGKYSQLTSSSLDSKLREDLERMKKIRAHRGMRHYWGLRVRGQHTKTTGRRGRTVGVSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4G5</accession>
    <name>A0A6P7F4G5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114325839</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325839</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129772.1">
        <property type="nucleotide sequence ID" value="XM_028273971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4G5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273971.2">
        <property type="protein sequence ID" value="XP_028129772.1"/>
        <property type="gene ID" value="LOC114325839"/>
    </dbReference>
    <dbReference type="GeneID" id="114325839"/>
    <dbReference type="KEGG" id="dvv:114325839"/>
    <dbReference type="InParanoid" id="A0A6P7F4G5"/>
    <dbReference type="OrthoDB" id="6507260at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129772.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56930" checksum="00DE8427480E21FA" modified="2020-12-02" version="1">MRDSMCSNKLLLYFLIGAFTISIFRGTKMAIEGLPLHRQEPDGDQDILAGADFLSVFMESSLRRAYAETTSTVSPTTIIVELEEVDYTTKREKRNSNAIDLRRDNSPTSYSSSLYTNTLPFSQSTEQVSDSDSSTNKDGVVVAVSVSSSVAKAVNSLYRRSTLLPIHKYFSSDRYSNLAIDNRRSRNNVYTIPTTTPPEPDTYAPQQLYSQVYTTSTTAKPFQNYFDIEQKPGIIAKASKSDLSVEESQPITKDSEIASDFSGSYPARVRIAPPFDQSAFLNQNIQQTDNQSYNPTFIYHDNPQDSDTARSISYSSIVQSLPQLTMEAEKTEPHERRERNYNDAKSPYINNLNIGVDKRKQNDSKILNWQDSESDQRNTEKPWSDQQKYTPTTPLPVELPKVYGQPEQNYEVDEALSVVTNGRAHGVQTTKSDKKPDDNQKFGYVVEGKNYRKYRVEERTADGFIVGEYGVVSHDDGSLRGVRYTADGTINPRLISEALMKFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F642</accession>
    <name>A0A6P7F642_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Uncharacterized protein LOC114326726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114326726</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130950.1">
        <property type="nucleotide sequence ID" value="XM_028275149.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028275150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F642"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275149.2">
        <property type="protein sequence ID" value="XP_028130950.1"/>
        <property type="gene ID" value="LOC114326726"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275150.2">
        <property type="protein sequence ID" value="XP_028130951.1"/>
        <property type="gene ID" value="LOC114326726"/>
    </dbReference>
    <dbReference type="GeneID" id="114326726"/>
    <dbReference type="KEGG" id="dvv:114326726"/>
    <dbReference type="CTD" id="35085"/>
    <dbReference type="OrthoDB" id="5979828at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Suppressor of cytokine signaling 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH2 domain"/>
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        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
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    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF0">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING AT 36E, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="320"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="9">
        <location>
            <begin position="410"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028130950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028130951.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55098" checksum="6A177BB5B63FD133" modified="2020-12-02" version="1">MKCKFYGFLNLVTNGLFQTMDNNACNCDDQDPVEEPTPSTSQAAAAAPKEPSKKSRLNFFNICRDRPLPFTKRDKKSPSTSKSSTFVKKSPKWGIRFNTTKKEFKVASTQDNQNCCQCTCYHRTGSNENNSIVGQNMVGAQENADDRERENAPSPSDSPVNIFDGGVPREEEAAMCASRVTEVNGVRGIYGTAPATSSIPNIIISAPFIDQWMRSQHEDCEEAARLQRAREIEEGVIAPANFRLIRRVQLLCSDNEESQAPRRLQLVCPPDLSVESLRALFQNHVTLRSGPIDTITGCHTQVDFIHCLVPDLLKITNCSFYWGKMDRYEAERLLDGKPEGTFLLRDSAQEEFLFSVSFRRYGRSLHARIEQWNHKFSFDSHDPGVYTSKTVYGLIEHYKDPTSCMFFEPLLTFPLHRKFTFSLQHLARAVIVSSKLTYDDINHLQLPKSLKTYLKEYHYRQKVRVERFDDDMQWLDLRDVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F970</accession>
    <name>A0A6P7F970_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myogenesis-regulating glycosidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114327016</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131312.1">
        <property type="nucleotide sequence ID" value="XM_028275511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F970"/>
    <dbReference type="FunCoup" id="A0A6P7F970">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275511.2">
        <property type="protein sequence ID" value="XP_028131312.1"/>
        <property type="gene ID" value="LOC114327016"/>
    </dbReference>
    <dbReference type="GeneID" id="114327016"/>
    <dbReference type="KEGG" id="dvv:114327016"/>
    <dbReference type="InParanoid" id="A0A6P7F970"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028294432" evidence="5">
        <location>
            <begin position="24"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="247"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="552"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131312.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="73178" checksum="6074142E30D58D9E" modified="2020-12-02" version="1">MSKGCHKLFTFLIFLTTLHSIRGIVVKNGNITLQLEPKSNGISFAAYDGKIKKLEGILGRGINFSNVDCIGTQVCVINDSNFSVEPISAGFRLKWKTFNTRRAFQDCYDLTEGVKWYGGPTIFSLIWPIQTNEIDGSSPYVLDNGKGMPYAERYWLNSKGSYIFLDDDVPLYVDQNKLRNNSVCFKSYIRDPFHAYFNRTRNVLQYYLIFKDDIKQAHLHAVNKFLGKPKDHPNEAMVAEPIWTTWAKYKTKINDSVVLKFAKDIRNHGYEKGQIEIDDNWERCYGAEQFSHNFTNIKDTVKILKSINFRVTLWIHPFVNDNCNNNSQIGLEKGYFVIDKYGRHTGWWWNSNDAYVIDFTNPQATEWWLQRVKKLQKDFGFDSFKFDAGETDFCPQPAVYKTVDQELIPNIFSGKYLRTCATFGNLIEVRTGWRTQDLPIFTRMLDKTSNWAYRNGLKSLVTTLIQMNMVGYTMVLPDMIGGNGYGVQPDAELFVRWTQANTFMPAMQFSFLPWDFNETKFDVPAIAKSCVKLHKEYSHIIIDAMKKSVLYGSPVNPPIWWIDPTDQKALKCDDEFLVGEKILVAPVLTQGATERDVYLPKGKWKDGNNGTYYQGPITLDYTADITTIPFFILEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9D3</accession>
    <name>A0A6P7F9D3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114327674 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114327674</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132161.1">
        <property type="nucleotide sequence ID" value="XM_028276360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276360.2">
        <property type="protein sequence ID" value="XP_028132161.1"/>
        <property type="gene ID" value="LOC114327674"/>
    </dbReference>
    <dbReference type="GeneID" id="114327674"/>
    <dbReference type="InParanoid" id="A0A6P7F9D3"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028110962" evidence="2">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028132161.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35384" checksum="0DCA1AF314E2AAE9" modified="2020-12-02" version="1">MYQYIVLLIILTSVRTFADDMSPEGYNSTEEYSIWTNFINETKSFLIEATNGLGDVIDHSDDVKPLTFVKFIIIENSTDIPEMTTTQATTVVEYINNHNIDTQDSNNDLYENDLGDIINNEVDSVQKNNKPSTTKPTEVLNQNLPATNTTQVTLSDAWDKFVEKVKLFMLTRDLEIFLPDVSFLTGKILRISLKNFVKNGDMIEMNLTLKNETVNVTDKIDQELKEGLQSSTPAQRNITFLMTIIYFFNIIYVLVTKLFGWLTLIPAMFYGLFELLFVNPILRMAQRLFNFVLYLHYLSINGTTVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGF6</accession>
    <name>A0A6P7FGF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114329903</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028134971.1">
        <property type="nucleotide sequence ID" value="XM_028279170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGF6"/>
    <dbReference type="FunCoup" id="A0A6P7FGF6">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279170.2">
        <property type="protein sequence ID" value="XP_028134971.1"/>
        <property type="gene ID" value="LOC114329903"/>
    </dbReference>
    <dbReference type="GeneID" id="114329903"/>
    <dbReference type="KEGG" id="dvv:114329903"/>
    <dbReference type="InParanoid" id="A0A6P7FGF6"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF63">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028134971.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="44813" checksum="52D1CDE980DB9610" modified="2020-12-02" version="1">MRLKRRRRAQVSGWRVMRRCVIFFTAICVIPVLLVLMVATDRYLQPVRRQTQYMHRQVNEVGKIQTGSLLNKNMSLIAKRLENRKRHMKNMCKLLGLDRPGNDSLHKPNSWEFLVDNKHHLIWCNVFKAASTSWMYNFNILAGYSPKFLKKSKLVPMTLARQKYPRPSLKDLRKAFNTSISFLIARHPLERLLSAYRDKLQYALPHTHHKKLGNEIIMKYRYKKNKKLSPTQRSPTFSEFVEYLVDSVKNREQLDMHWAPIVEFCTPCMFNFQVIAHAETLQEDQMYLIKIAKLEHLIQPEWKNAGRGATQNQIGRYYSELTRSQIFQLYHIYRYDFELFNYSLHGYLEYGIPDNDPSSLLAAISMKDFQQNDLPKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGP4</accession>
    <name>A0A6P7FGP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327888</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028132405.1">
        <property type="nucleotide sequence ID" value="XM_028276604.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515859.1">
        <property type="nucleotide sequence ID" value="XM_050659902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGP4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659902.1">
        <property type="protein sequence ID" value="XP_050515859.1"/>
        <property type="gene ID" value="LOC114327888"/>
    </dbReference>
    <dbReference type="GeneID" id="114327888"/>
    <dbReference type="KEGG" id="dvv:114327888"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF21">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028132405.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="30524" checksum="103D69FBF5F97E45" modified="2020-12-02" version="1">MAIITDIVNDLTGNIDPRHDAYITASPYFLYGFLFTYIFTIKILGPKLMRYRQPYNIKNLLIGYNFIQILLNTYIVYEAIIVYFSNSNWICIDTTEKNILADARKHYYFLKILDCVETVFFILRKKYQQASFLHIYHHTGILCAAFLAFRYDYGDTTWIIGGLNSLTHVFMYVYYLLSAINSRWSKYTTIKKSLTLLQIVQLNVILFSLAITKLIPECYSVPTYSLVIWIFQNVFMINLFVRFYIKSYVNNQKSVGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMG2</accession>
    <name>A0A6P7FMG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329362</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134230.1">
        <property type="nucleotide sequence ID" value="XM_028278429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMG2"/>
    <dbReference type="FunCoup" id="A0A6P7FMG2">
        <property type="interactions" value="1044"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278429.1">
        <property type="protein sequence ID" value="XP_028134230.1"/>
        <property type="gene ID" value="LOC114329362"/>
    </dbReference>
    <dbReference type="GeneID" id="114329362"/>
    <dbReference type="KEGG" id="dvv:114329362"/>
    <dbReference type="CTD" id="6218"/>
    <dbReference type="InParanoid" id="A0A6P7FMG2"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134230.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15377" checksum="9743D215C54724BF" modified="2020-12-02" version="1">MGRVRTKTVKKASKVIIEKYYTRLTLDFHTNKRICEEIAIIPTKPLRNKIAGFVTHLMKRLRHSQVRGISIKLQEEERERRDNYVPEVSALEHDIIEVDPETKEMLKMLDFNNISGLQLTQPATNTFNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMI0</accession>
    <name>A0A6P7FMI0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor SOX-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114331985</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137479.1">
        <property type="nucleotide sequence ID" value="XM_028281678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMI0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281678.2">
        <property type="protein sequence ID" value="XP_028137479.1"/>
        <property type="gene ID" value="LOC114331985"/>
    </dbReference>
    <dbReference type="GeneID" id="114331985"/>
    <dbReference type="KEGG" id="dvv:114331985"/>
    <dbReference type="InParanoid" id="A0A6P7FMI0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22029">
        <property type="entry name" value="HMG-box_SoxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000007">
        <property type="entry name" value="Transcription factor SOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028137479.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37272" checksum="3A69631B5029F23F" modified="2020-12-02" version="1">MLPQTMDASRSETPSLSGQPIFGSQLVDKNSSTPYSDATQTKKNNPNHIKRPMNAFMVWSQIERRKICEVSPDMHNAEISKKLGRRWKQLNDEERQPFIEEAERLRQLHQKEYPDYKYRPRKKSTKPTPKPSSSKKNKKSSKLHKNDTNNNSSIVNEKIYARRSTVPESVASKLKFRLTNVAEQRQLNRIVETEDHIRQSMPLPPMSFLAKVPSSPSCDTPDSPESATIYDDTWVSQFTTVKEEPEDRLSHPQITPASLDDLDRIDDLLPMDGINLEELADIDTNFDTASNSSGSHLDFSCPKDIPMFSNIENETWAEMQTAAFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNU9</accession>
    <name>A0A6P7FNU9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EEF1A lysine and N-terminal methyltransferase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114331171</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136467.1">
        <property type="nucleotide sequence ID" value="XM_028280666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNU9"/>
    <dbReference type="FunCoup" id="A0A6P7FNU9">
        <property type="interactions" value="2124"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280666.2">
        <property type="protein sequence ID" value="XP_028136467.1"/>
        <property type="gene ID" value="LOC114331171"/>
    </dbReference>
    <dbReference type="GeneID" id="114331171"/>
    <dbReference type="KEGG" id="dvv:114331171"/>
    <dbReference type="InParanoid" id="A0A6P7FNU9"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000110">
        <property type="entry name" value="methyltransferase-like protein 13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF78">
        <property type="entry name" value="EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028136467.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="75773" checksum="A7B824A76CDD8E74" modified="2020-12-02" version="1">MNLLPKSKEQFSQKEYWDTFFKKRGNKAFEWYGEYPELSQYLHKYIKKQDDILITGCGNSTLGRDLYDIGYSGITNIDISQVVIRQMLSQNEKPRSNLKYIQMDALNMTFDNEQFSVVLDKGTLDALMPDDSKATIENIKKYFNEILRVLRVGGRYICVSLLQEHILKYALEYFPSNNFMFRIVRCFEAERKAIENGENSLPVFIVVCTKFKALIQKVLELNLGSADKMHRCSNPSELLAQVRDAQNAAFICSGLKRTSIAEESEVVLELFEQGSSGTRFTVYVVDIPQQKDFSKYAAFIVPEGREAEWLFSTPNGRKKLVEITRNNRLAIITLHRGQKYESFDAVQVELTDFICNLAPPSLKTKQIPFLSLGSDVGHRIIKHEGHSEASGDFVIEDVITENDEKYRRLFYMNSQNVIQSEAKIRTIKSRKGATREVIDLIYLTCRHHIYMAIASYVACRGKTKSNISVVGLGGGGLCSFLHKFLPKTNILGIDIDEDMLKIAKEWFEFKEDDKLKARIQNGLDYLKESAEKGEAIDALLFDVDSKDSSIGMSCPPQGFLNKPVLENVVKILDKSGIFVLNVVLRENSLRPGVLTSLKTHFQNILSYKLQEDLNEIFICSNSAIEIEQIREGCSEINSLFRKHGIKENGVDAEKLVSQLVVQSVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRC8</accession>
    <name>A0A6P7FRC8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter G family member 23-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114330397</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135543.1">
        <property type="nucleotide sequence ID" value="XM_028279742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499810.1">
        <property type="nucleotide sequence ID" value="XM_050643853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRC8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050643853.1">
        <property type="protein sequence ID" value="XP_050499810.1"/>
        <property type="gene ID" value="LOC114330397"/>
    </dbReference>
    <dbReference type="GeneID" id="114330397"/>
    <dbReference type="KEGG" id="dvv:114330397"/>
    <dbReference type="InParanoid" id="A0A6P7FRC8"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF2">
        <property type="entry name" value="RH61964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="477"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028135543.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="79750" checksum="F4EA38F29964C9A3" modified="2020-12-02" version="1">MHDDYAVFVDRVVKKYGQKEVLTGICMKVERGSIYGLLGASGCGKTTLLSSIVGRKKIDGGEIWVLGGKPGEAGSGVPGPRVGYMPQDIALVGEFTVKDAIYYFGRIFSMEDSLIAKRYRNLHTLLELPPDDRYLKNCSGGQQRRVSLAASLVHKPELLIMDEPTVGVDPVLRDRIWKHLVDITKKDNTSVIITTHYIEECRQANKIGLMREGKLLAEESPTRLLTLFNSETLEDVFLLLSKRQEEGRLQELTSHRVVDDQNNSMLANDTTGSTTSVATSVSTFEIGHGSTDILAKKKILKARNALNKSRMKALFDKNLKQFYRNITGIIFLMTFPILQVGVFMGAVGGDIRSIPLGIVNDEAMSVTCPGFSFNGTATATDDRACQLRNISCRFLSYLDHPMIEKVHFETLEDAKDAVLHGKIVGAMYMSSNFTSFLEERIDKGKDIEKDILSLSEIKVWMDMSNRQIGATLKYKLIDLYTKFQNSLFDDCDFVPGFGDLPVNINFIYGDGDEPYTVFMIPGSLITIMFFMGAIMTSQIIITDRHDGVWDRSIVAGVTSLEITITHLVLQASICIIQTAELLVVVYLIYQQEYSGSLWLMYVMVYLQGICGMAYGFWVSVISTDHSMANTVLTGIFLPMMMLSGLMWPTEGMPPALRIFSRCLPFTMAIESLRNVSKRGWSIDNFQVYSGMGVGFMWTVFFGVLSVYLIKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVF3</accession>
    <name>A0A6P7FVF3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RuvB-like helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114331368</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 14">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028136720.1">
        <property type="nucleotide sequence ID" value="XM_028280919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVF3"/>
    <dbReference type="FunCoup" id="A0A6P7FVF3">
        <property type="interactions" value="1684"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280919.2">
        <property type="protein sequence ID" value="XP_028136720.1"/>
        <property type="gene ID" value="LOC114331368"/>
    </dbReference>
    <dbReference type="GeneID" id="114331368"/>
    <dbReference type="KEGG" id="dvv:114331368"/>
    <dbReference type="CTD" id="53439"/>
    <dbReference type="InParanoid" id="A0A6P7FVF3"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028136720.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="49709" checksum="1047C55FD4DED802" modified="2020-12-02" version="1">MKVEEVKSTVKTQRISAHSHIKGLGLDEAGFAIPSAAGLVGQEQAREAAGIVVDMIKSKKMAGRAVLLAGPPGTGKTAIALAIAQELGNKVPFCPMVGSEVYSSEIKKTEVLMENFRRAIGLRIRETKEVYEGEVSELTPVETENPAGGYGKTVSHVIIGLRTAKGSKQLKLDPGIYEALQKEKVEVGDVIYIEATSGAVKRQGRSDAYATEFDLEAEEYVPLPKGDVHKKKEVIQDVTLHDLDAANAKPQGGQDVLSMMGQLLKPKKTEITDKLRKEINKIVDKYIDQGIAELVPGVLFIDEVHMLDIETFTYLHRALESAIAPIVIFATNRGRCLIRGTDDVYAPHGIPLDLLDRLLIIRTIPYGRSDMEQILKLRATTEGLEIDHEAIASLGEVGAKATLRYAVQLLTPAHLTAKINGRNNILQSDIEEVGSLFLDAKASAKVLSENKEKFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVF5</accession>
    <name>A0A6P7FVF5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114333094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114333094</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138727.1">
        <property type="nucleotide sequence ID" value="XM_028282926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVF5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282926.2">
        <property type="protein sequence ID" value="XP_028138727.1"/>
        <property type="gene ID" value="LOC114333094"/>
    </dbReference>
    <dbReference type="GeneID" id="114333094"/>
    <dbReference type="KEGG" id="dvv:114333094"/>
    <dbReference type="InParanoid" id="A0A6P7FVF5"/>
    <dbReference type="OrthoDB" id="6725215at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028088125" evidence="3">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028138727.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13392" checksum="2F466F582792C6A8" modified="2020-12-02" version="1">MSKIVLLLFTIGAMAVFSAAKQEPTVCYSCTIYDGDLCNDLDLSNRTKVRCPDMPPDNKTTSGVACYTIYRTLYGTTLTERGCTYTEVDGEDVCSHVDNKGYTCDFCYEDLCNDKPIYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G028</accession>
    <name>A0A6P7G028_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114334535</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140402.1">
        <property type="nucleotide sequence ID" value="XM_028284601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G028"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284601.2">
        <property type="protein sequence ID" value="XP_028140402.1"/>
        <property type="gene ID" value="LOC114334535"/>
    </dbReference>
    <dbReference type="GeneID" id="114334535"/>
    <dbReference type="KEGG" id="dvv:114334535"/>
    <dbReference type="InParanoid" id="A0A6P7G028"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027612808" evidence="2">
        <location>
            <begin position="22"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="199"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="401"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028140402.1"/>
        </source>
    </evidence>
    <sequence length="612" mass="70025" checksum="F56C662A9981B7DD" modified="2020-12-02" version="1">MFPKIRFTIFVSVLFLAVATAQDPSGWENVFASNRSHVMPLRHFEGKTYYLGYHIKASYMIAMQFCSNIHMKLLSIRSEKENTMIHKFMRDANKLGGYWTSGAKFLDNVNWIWMAYGQNIEYTNWGKNQPDETNDKCLQVYSNGYNLLWNDLNCDALNYFICERYEPKIYASYLNNRESTWDDLLSQSSISANIGLLHFGQKKYYFAKYISGSFMQAIEFCKIINMQLVSITDKEENDRLSKYIRDTNSGNSWWSSGSRLLDGKNWVWFTKGTPIEYTNWGLNQPDTNDEMCLKLVHSNDNGIKWADEYCTAANRIICESNDADDIDYDRDFPGFGYPNSPYPYGRNPPNGRYPNSRYPVGKPALNNRGGLTQLPVPTRSDEEWEELLQDPDRTPFVSRYHGGKRYHVETLIPGTQKQAARFCEYHEMQLLEVNDEYVNDDLAWLLLDLQNVSGPYWIGGKKILGTWRWPTAQQDITYSNWAVGKPSRRGSKECIQVDQMGFWSDEDCNNVRYFICEVQMSPGKPVPTKPSVSTGQGQCPEPVINVYINTNLDGDSSSNLISSKDVKLSDSGYQVLVNNKINLDKNAAGGNGNIAKTTTESYYDQLNGLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1G6</accession>
    <name>A0A6P7G1G6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC114333226</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138887.1">
        <property type="nucleotide sequence ID" value="XM_028283086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138888.1">
        <property type="nucleotide sequence ID" value="XM_028283087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1G6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649602.1">
        <property type="protein sequence ID" value="XP_050505559.1"/>
        <property type="gene ID" value="LOC126883902"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649603.1">
        <property type="protein sequence ID" value="XP_050505560.1"/>
        <property type="gene ID" value="LOC126883902"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505559.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028138887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028138888.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="54888" checksum="22FB5C39C6DCAB94" modified="2020-12-02" version="1">MREKSLVQMFQGTLPQLIAVLTGTIGAVSDGMHYGWTSPVLPVLQKNGTHIHISERDQLWLESIYMIGGITGLPVTIFAVDTIGRKGSIIISAAIALVSWILIAIADKTLYLYIARFMVGLSGDVAFVAAPMYIAEIADKRIRGFLAGIIYVMMLLGILVIYAVAPYVPFYVPSIIGAVLVIIQLVSFPFVPDSPYYLLAKGEKEKAKRHLQRLRGREDVDQELKEITDAINRQEKEKGRPKDLILTASNRKAVIIMIVLNAAQHFSSISVMLMNLHEILHAADSAYLSSEVAGILFAALMLTAATIADVIVDKFGRKSLLTISSLLTGVSLLILAIYFTLKKVGYDTSGISWIPVVAVMIYAAVFKFGLGIIPIVMTAELFPAKLKAMGMTIADCAYVLFAWMSVEIYQRLSGTYGYDLPFYIFAFSCILTAVFAQWYIPETKGKTLDEIQFILKGVPFPQRSNSIRSESISLGSVRDNKTRENSENKISEAESTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6G5</accession>
    <name>A0A6P7G6G5_DIAVI</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114338247</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114338247</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="LOC114338247"/>
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    <dbReference type="GeneID" id="114338247"/>
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    <dbReference type="OrthoDB" id="126772at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR21179:SF1">
        <property type="entry name" value="KAZ1-TYPE SERINE PROTEASE INHIBITOR-LIKE PROTEIN TYPE EPSILON-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
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            <begin position="1"/>
            <end position="18"/>
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            <begin position="19"/>
            <end position="168"/>
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        <location>
            <begin position="114"/>
            <end position="167"/>
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            <begin position="53"/>
            <end position="76"/>
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            <begin position="56"/>
            <end position="67"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="PROSITE" id="PS51465"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028144644.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="18802" checksum="06401F319C70CCD7" modified="2020-12-02" version="1">MKCLCIFVVAIAVLGVSCLPSRQRRQFDWAEWETNANQVRNRNINRNIRQSWNQQGGRQIPTNSWNPNGPDFSDPDFNQDPNVNIQIPSIQIPNNQLPVDNGVTPDGSTTTTASPAYTRCFANCRTTSEYNPVCGTDGNNYDNPQRLNCARSCGRNVQLRRGGTCQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6Z1</accession>
    <name>A0A6P7G6Z1_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Zinc finger CCHC domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334448</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140290.1">
        <property type="nucleotide sequence ID" value="XM_028284489.1"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="XM_028284489.1">
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        <property type="gene ID" value="LOC114334448"/>
    </dbReference>
    <dbReference type="GeneID" id="114334448"/>
    <dbReference type="KEGG" id="dvv:114334448"/>
    <dbReference type="InParanoid" id="A0A6P7G6Z1"/>
    <dbReference type="OrthoDB" id="7473079at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140290.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13840" checksum="66C0E50CCF9442D9" modified="2020-12-02" version="1">MPGNENLLPEDSISFNETPTIANENTSNDLCLPSTSNIVNMGQRKNYYISPIRSNESDIDDSDADPNFDVSPNKLFSNRLFPTANSSSSSSSSSSSTSSDSSDSASESSTVSNIEDNGERKGKKKSLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCF7</accession>
    <name>A0A6P7GCF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114336384</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028286742.1"/>
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    <dbReference type="FunCoup" id="A0A6P7GCF7">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286742.2">
        <property type="protein sequence ID" value="XP_028142543.1"/>
        <property type="gene ID" value="LOC114336384"/>
    </dbReference>
    <dbReference type="GeneID" id="114336384"/>
    <dbReference type="KEGG" id="dvv:114336384"/>
    <dbReference type="InParanoid" id="A0A6P7GCF7"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="9">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028142543.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="44959" checksum="BBCCC6D2F41A0238" modified="2020-12-02" version="1">MQRRVVVTGLGVVSPVGTGVKEAWKNIISGKSGITRLEGPEYESLPCKIGGYAKDKGEKISLSNYFSKSELRTMAPATGFALISAKEALEDAKLDQMDENTKNTAGVAVGMGMVDLQDICSTYDALKKGYHHVSPYFVPRILPNMAAGQISIKYGLRGPNHSVSTACATGAHAIGDSFRFIRNGDADIMICGGTESCISPLSIAGFSRLRALSTSFNDQPEKASRPFDKLREGFVMGEGSAVLILEELQHALDRNAHIYAELLGYGLSGDASHLTAPRSDGAGARSAMERALKDSRIDSKQVTYINAHATSTPIGDSIETRAIKDLFGPSTNNISVSSTKGAHGHLLGAAGNLEALFTIKAIEEGVLPPTVNLENIEDNEINFVPIISQKWKKCDRRIALKNAFGFGGTNASLCFGQFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF01</accession>
    <name>A0A6P7GF01_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thyrotroph embryonic factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114341563</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148171.1">
        <property type="nucleotide sequence ID" value="XM_028292370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF01"/>
    <dbReference type="EnsemblMetazoa" id="XM_050651902.1">
        <property type="protein sequence ID" value="XP_050507859.1"/>
        <property type="gene ID" value="LOC126885345"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GF01"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028148171.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26704" checksum="598AE31FC996032C" modified="2020-12-02" version="1">MMDFYLERTRMMEHHTVLPHNQLSVFYPMRQHNPGDDFLENPAVLDLCVRKRPLSPNYPYDYKRARSYSEVSCYSPKSDVSDVSSTEHRDTQVSSPKIKCSRPFKAYTKDPMSMPILSTTPNMLGKDSSEAYAEFREKILSRAQANHNGTNKNMRRTQTTNIQNSDPTYWEKRKKNNEAAKRSRDARRAKEDEIAIRCAFLEQENIQLKFSLAALENERERLQSILYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIW8</accession>
    <name>A0A6P7GIW8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114343255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114343255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149861.1">
        <property type="nucleotide sequence ID" value="XM_028294060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050651357.1">
        <property type="protein sequence ID" value="XP_050507314.1"/>
        <property type="gene ID" value="LOC126884972"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIW8"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027650403" evidence="1">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028149861.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12120" checksum="6CAD05D657E6338C" modified="2020-12-02" version="1">MKFIVLLFLVAAVNARFGSQDDLAVLASVDRPNRPFRLSDCLLHADSDPCSGNGRDTYPVWKWDIFLRSCVRASARSSCTPTHNNFPTHEACSKLAGIICRKLRSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJ98</accession>
    <name>A0A6P7GJ98_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114343127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114343127</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149739.1">
        <property type="nucleotide sequence ID" value="XM_028293938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJ98"/>
    <dbReference type="FunCoup" id="A0A6P7GJ98">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293938.2">
        <property type="protein sequence ID" value="XP_028149739.1"/>
        <property type="gene ID" value="LOC114343127"/>
    </dbReference>
    <dbReference type="GeneID" id="114343127"/>
    <dbReference type="KEGG" id="dvv:114343127"/>
    <dbReference type="InParanoid" id="A0A6P7GJ98"/>
    <dbReference type="OrthoDB" id="6421972at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028149739.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="39293" checksum="4EC16ED4586B0AB6" modified="2020-12-02" version="1">MSSALEMDNLEDAKKLVRDLRQKTRAQAQQIMAWRKAYKMQEIMISRIEREKSDQLKALSSKLLLFESRLIRKQKDISTMLNIRETIIQRQQKIIETLSNRLQDNGLEIPMQAEITELEFAFPDLDSLNDSDSAVVMEDLDCENTYQVPKFRNMDGVTVMRSISDAIDPNLKYSSVRRNNGFLRRPEVLETVYSVEEDADNDQENKSDAIKRRESFASRGKSNCNTESQVIRDRSLEENVIVNIKSNSLDETMSDNPSWSYNNEKPTEGTEDNSKNQVKKYNRVMSNHRSVTKPKDVKYKRINKAKSKSLEELRGKLKNWVEQGTKISSFSLEHSQSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL12</accession>
    <name>A0A6P7GL12_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rac GTPase-activating protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114339450</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145913.1">
        <property type="nucleotide sequence ID" value="XM_028290112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL12"/>
    <dbReference type="FunCoup" id="A0A6P7GL12">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649087.1">
        <property type="protein sequence ID" value="XP_050505044.1"/>
        <property type="gene ID" value="LOC126883494"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GL12"/>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04382">
        <property type="entry name" value="RhoGAP_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="373"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028145913.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="70960" checksum="257DF9DCBDBA746B" modified="2020-12-02" version="1">MCDTPFKSPYPSKKAKLARTDSDESVTSETGSTGSAGSINDLTIVALYDELQRLYHQKVEDRDKLHDSFYNFAEQTKLLYQEWTKTIAECIRLRNEVDQKIEEGNEYNRRLKNARKMLDEESKKRKLAEQERDEFKHQIAKFCNILVKDSRNKLADDAKEQISNLYSGRMSFGDPERLSAIKEINSTGSILSDFSYSRSEDDLDSSRCMNKPTKEWKRQQTDLMEEPANKKRRSTSNKALEVGITDTIKATTTLTLNKDGPITATSIIESIPKSDGECVAPPNLILESWNRQEEKITASPYVDINSNFRQHCLQQKTIMIPIICSVCEKHIRFGNKAYKCKECRMSCHMECKDLLPTPCVPVLHTPSARKFTGTIADYTPTSAPMVPSLIVHCVNEIERRGLTELGIYRVPGSEREVKGLKEKFLSSRVAPNLKEIDIHVICGCVKDFLRSLTEPLLTYTLWNDFVTAVKAKDSNDIMPAIYETISKLPQPNRDTLAFLILHLQKVAQSPECKMPKDNLCKVFGPNLVGYSSSNPEPNKLIQETKYIIKVMTYIMNIPQDFWKNFITVCLTPSTHCNTLQQTPSTDSLLRPTATRFFTPSGRSESKFRKKREGKFFGTPPAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPW8</accession>
    <name>A0A6P7GPW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114340673</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147243.1">
        <property type="nucleotide sequence ID" value="XM_028291442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPW8"/>
    <dbReference type="FunCoup" id="A0A6P7GPW8">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641574.1">
        <property type="protein sequence ID" value="XP_050497531.1"/>
        <property type="gene ID" value="LOC126878710"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GPW8"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF10">
        <property type="entry name" value="SERINE PROTEASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027550568" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="284"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028147243.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="56501" checksum="480479DFDC8662C2" modified="2020-12-02" version="1">MRLTVHICLCLTVISLKVYAEDDLEGVVVEAAALPGETRSSRQFYFRGPSIPVYNPFMIPQVWSSFSTNSLNIPTIGQCFTAKGVVGKCTSFRQCYPFFKIAEFGNFESWVLGMYDTCSYYTAQGRQMFGVCCTNPNPGKPAESSPGSSTELPIVEAEDTVIDALQTNSSAIPYFPQIFNWPPPLPTHSPDNTIPPLPTHPPSLGLPTVSPTAWPPTSNKPVSPIYQPTVKPIYQPSFPTYKPPTYKPPTHKPTSKPTIATVATPALPVGACGAKNGYQDQKRIVGGHNAEVNEWPWIAALFNGGKQFCGGSLIDNNHILSAAHCVAHMSSWDVARLTVRLGDHNIKSNSETRHIEKRVKRVVRHRGFDSRTLYNDIAILTLDSPVDFNQQIRSVCLPTSSTDPTGKTGTVIGWGSLRESGPQPAVLQEVNIPIWNNLNCKSKYGPAAPGGIVEHMLCAGEANRDSCSGDSGGPLMINDGKWVQVGIVSWGIGCGKGQYPGVYTRVEKFLPWIQKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GRK1</accession>
    <name>A0A6P7GRK1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ankyrin repeat domain-containing protein 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC114339947</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028290634.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050647350.1"/>
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        <property type="gene ID" value="LOC114339947"/>
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        <property type="term" value="P:protein K6-linked ubiquitination"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="ANK"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028146435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028146436.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17809" checksum="6B3F2D1CE0FC79FE" modified="2020-12-02" version="1">MCDHNCKCSAHPVASQSLDEMDFERGIWYAAQYGDLERVRKLANERRCADEKDSAGYTALHYAARNGHLTVCLFLLDNGADVNAVTKGGATALCRAATAGKEDVVDLLLSKKADPFIQDSDGKTALHRATENKHFEICKRLLNVAPSLCEVADNRGNKAAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GUZ7</accession>
    <name>A0A6P7GUZ7_DIAVI</name>
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        <recommendedName>
            <fullName evidence="16">Histone-lysine N-methyltransferase trithorax</fullName>
            <ecNumber evidence="2">2.1.1.355</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC114343203</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="26">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.355" evidence="2"/>
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        <property type="nucleotide sequence ID" value="XM_028294011.1"/>
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        <property type="interactions" value="1301"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663648.1">
        <property type="protein sequence ID" value="XP_050519605.1"/>
        <property type="gene ID" value="LOC126893446"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GUZ7"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140949">
        <property type="term" value="F:histone H3K9 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SET_KMT2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047219">
        <property type="entry name" value="KMT2A_2B_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE TRITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45838">
        <property type="entry name" value="HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="22">
        <location>
            <begin position="238"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="568"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="694"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="23">
        <location>
            <begin position="949"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="2484"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="21">
        <location>
            <begin position="2606"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2277"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="2289"/>
            <end position="2312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_028149812.1"/>
        </source>
    </evidence>
    <sequence length="2622" mass="294504" checksum="1FF186DE32E1CDA5" modified="2020-12-02" version="1">MGRSKFPGKPSKHIHRKRVNVLPPTGEITNIEYNTSVIVGSVVENKQDEDLTESDSESAPPENALKKSVSIRRRLTRKRNLNSSLRNKNVTKRTLLSKMCTKSSVKTKLKSTLNQKAVHTCNGSCCNKVSKETTNLVGKFVLPTRSVHSSRVIKPNKRFISDINEAVTLKKKVSIVKRHCVKQEDDKAKFLESGSLNGDKTTFTNGHRVVLRQARLKIPNQIGLQGPFSTKPNSSPGAVTCGVCGAIRFYRFIKQARKFNIYSCESCRKFIARMIKRQACGNENNQITLVCNKGQGNCLLPPVVRNQQWKLNKCTYRAKCSACWLKLCVRAFYLPPSLKQGLSLMLPKYMQGLDVSLSNTQSPSLWQANVETKLVIEKPQEATMKKRPVRSKNPKSQVIAVPSGTNSDIKRQKIDLKGPRVKHVCRSASIVLGQPFAIFPEGEKKCDNQEQENDIKIAEDKTASDKSINEVKSTVFWKNDSIPSEPESSCSDGSSKNSSSESADFTKRERLLRNVSTLQSSIQPKSDRKRNLVDPQTAILIDFWDGFDPEVVSQYGFCIIGSERFTMPSICFLCGSAGKESMLYCSICCEPYHSFCLEQFQTVPIDKGLKYYTWICPRCTTCNECNKVDRLKVNCQKCLKSYHPECFNSKWNSEDKPSVCSKCVKCKSCGTPNITKFVGNLPLCMSCFKYRKMGKFCPICQHCYDENDCCSKMMECAKCCKWVHANCEHLTEDQYQMLSVLPKSAEYLCPSCCNSPGSIPNWKKAIIHEMKSSFIHILRQLSKNKTARTLLKWSPVHDTTSSNKTVTHARKLQFLDGSLDMDNNNSSKEPLDINKIYSFEENERYEASLNKVTNTLSVVDIKNKLLSNEYSSITEFNKEIEESLKSTNSEELLKIYQSIFHDVFPWYQNASKEDLSDGLKKDSVGESQDTIDDTIPSLFIDLALPVIDTRLCVFCKGIGDGSSSKESRLVYCGQNEWVHANCALWSSEVYEEIDGSLQNVQNALNRGRLIRCAHCKQKGASVGCCFKGCHETYHFPCARSCKLKFLYDKTVYCSSHDLPKNSHIISLEKEFDIDRSVFVEVDQKKRKYSAEIDKTTFMIGSLCITNLGKIDPIISDTTECIIPIGFACTKMFWSTTEPWKLVPYTVTVSVKNYNSNTLIIDRNFTIDHSRDKLVVEKMLREINIWQRDLDRKVSDIDSEDDEEQRTVLLSPELTDAILEELPHDLLDGISVQDIFPKFSYDELLDYKHDLNLSESYKRSDIDEDLDVDMKNKEYKKNKIDALSKTRATSKSCSLTLSCKLDSSLSPSVKKRKIATTRETNVMYQLLQVDGNLDDCSSSECGSPSEVTGTNVWGSYISEEPVTCDKCQSTYRTQASYARHLESCESFSASDDDSELNVEQEILPTYTNSNTNFIDNQVVVDVNEPVLISSFESYQSEIHTSVLNTQSFVTSKSSSEVVPSEIIIPSISQATEHKPVLHSLSVNAVTPLTLETSQPEQTFSINQPTIINDPGVSVHTNQAQFCVNQTVPLCVNQPITLQQNNIQVNPSTYSGNQVSFINPNASISINSVQPTNSAQLNQQQLDFQTPSVTIQPVSYNNIINVGSQNQFTLNGKLIQNPVLQAVNVQGAQWVRQVAKPTIVTQKTVKPRNRSRALAARRNQCEQGAIILPQNSSQVIVQQLPSTSYVPFVDAFQQPGQNIQYVTTLAPQVNTVPAQSIVQIQPDTNIISIVPGLQQAMYIQQPRVENQLVVDSNGTLGWSQQQTVQPVYYGFETIVQNTVMQSQQFLPTTMPGVLTANSSYSTTTQVFQTSKLEPVLDVTSNSFVLVNPGQLVNSQPIVNTQPIVNSQQIVNTQPQSIINSQTMVPQQVVSQQPVINSQIVSQQPIVSTQPVINTQPVVNSQPVVHTQPAVNSQPFINSQPIVNSQAIVNSQQIVNSQPVIPSQQLESTHNTHHLTASHEADPFINTPTVTSPPSIVTPRPVELQQVQNIKINTINNVLPQRKEIIRQDIKKEMSNLPTGIQNISMLPQKQEPKISHSQIPMKTSPNTMPIPMQPVKYNQAPNKPAAPASSQILLPTAPFVSEQRIPTNIVTPIPKPPSVSSRPMNRVLPMLTNNTKGPKKNFDDKLFFPDEKKKPIQIQKVYEIKASKPKLESIKTVEADSKLITPIFDPLPIPKLAVIKEEKKDKRLKQELPPKTCKSIESESVLKLDPPKVEPIKIDPPEEKEPIVEEIKPVQTTISADTKLDTSLKLIFQKQGQDGTYKISSNFSTKQPVQVVPLKPIKSNYTPPPLEKPKKKEIKPLEPEKFEESSKSQLAKKESETTSIMYTIETREGFKYTSSSVGDLWSRVLETVQSARVAHNMPPLPTNNGSLLNSLQILGFKSNGSKFLLEQLPGASKCTKYQSVFNFPPHASEMDSELTQDHIHGAIRCAPYENNNKEPYDMFGWLSSQHRQPAKISLESQEQTSRRVVNLPMAMKFRQLKLTSKYSVGVYRSPIHGRGLFCLRDIESGEMVIEYAGEVIRSILTDKREKLYNAKNIGCYMFRVDDNFVVDATMKGNAARFINHSCDPNCYSKVVEILGHKHIIIFALRRIPSGEELTYDYKFPFEEDKIPCTCGYKKCRKFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H5V8</accession>
    <name>A0A6P7H5V8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114347424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114347424</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028153932.1">
        <property type="nucleotide sequence ID" value="XM_028298131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H5V8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028298131.2">
        <property type="protein sequence ID" value="XP_028153932.1"/>
        <property type="gene ID" value="LOC114347424"/>
    </dbReference>
    <dbReference type="GeneID" id="114347424"/>
    <dbReference type="KEGG" id="dvv:114347424"/>
    <dbReference type="InParanoid" id="A0A6P7H5V8"/>
    <dbReference type="OrthoDB" id="6794778at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027620987" evidence="2">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028153932.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11113" checksum="042923C95DB85D1C" modified="2020-12-02" version="1">MMCKLLLATLAVYLCLEAASAQHATGFNPNQNRQPHATGLIVPNGYQRHATGLNPGRRTGRVYRDLSSADTGRNHRKILGAHANSNGPTHPGLPLAPGPVIHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGJ2</accession>
    <name>A0ABM5IGJ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132288.2">
        <property type="nucleotide sequence ID" value="XM_028276487.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276487.2">
        <property type="protein sequence ID" value="XP_028132288.2"/>
        <property type="gene ID" value="LOC114327778"/>
    </dbReference>
    <dbReference type="GeneID" id="114327778"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046529501" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132288.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="264" mass="28530" checksum="B34D53B4F45B5CFD" modified="2025-10-08" version="1">MYNYYCVYVALVSSCLYLSNAGTPPLENSEKSNNLGIIDGQEVIPHSMPYMAAIRSEINYTTVLCGGSLISDSLVLTAARCVYGASEVTVTLGAHNLTINEESQVTMTSTSFVIHEDYKHSGVLHDIAVIELPKAVTLNDYIATIKLPDFADISNSYEEQAASVAGWGRVNDAEQLNSDVLLYQNFTIIPNIMCELSYLFQIQSNQLCTSGVSGKNICLGDNGSPLVLNGVQIGIASYGTVFGCSLGFPGVFTRVTSYLGWLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IML7</accession>
    <name>A0ABM5IML7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NACHT and WD repeat domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136573.2">
        <property type="nucleotide sequence ID" value="XM_028280772.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280772.2">
        <property type="protein sequence ID" value="XP_028136573.2"/>
        <property type="gene ID" value="LOC114331260"/>
    </dbReference>
    <dbReference type="GeneID" id="114331260"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052752">
        <property type="entry name" value="NACHT-WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057588">
        <property type="entry name" value="NWD1/2-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871">
        <property type="entry name" value="BETA TRANSDUCIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19871:SF37">
        <property type="entry name" value="GH25853P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25469">
        <property type="entry name" value="WHD_NWD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ATPase" evidence="5">
        <location>
            <begin position="477"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="NWD1/2-like winged helix-turn-helix" evidence="6">
        <location>
            <begin position="710"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1265"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136573.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1373" mass="155280" checksum="80886C16C07D6294" modified="2025-10-08" version="1">MGNSCSSGQAHKDKDNMSQRSEESGSYQVRASLPSEKQQTLLNHITPHSGVILEPTTAGKPQLPSGNTPTTTASALEHKPSLTKSFKGTTITSVSDSMSLSSPPGNQSPKDFDKLFDSNVPKEVSDLSENLQCLIMGKVAQTKTVLKSRKIVIYICAADSQDCNVEKGALHNTIYPELRANCRSRGYELHIVDLHWKTLLEKQQDHEFPELCIGELTRQMEVAYIIPVLFLNNSLGTQLLPITIETQDFNVAMESAENQSAQGLLSKWYMLDSHAQPPCYRLRPISCHIPGFKETSLQDREKAFAEWASEIDKMLAVLITVFSQELKDTYLTTVVEQEVHNTVFMSQELAKRCIWLNRIYTPTAKTPDNMSPGEAEAHRRLDILQKDLKNQLAEKHIVRIPVKYVEGGLNIQIPEHEEYLANVVHHLKKHLSEMINTIIEEHQSKTMLKPSFGIEATLFEELNQQTTFCQKAAQCSTDREKTINEVKGYINGNSTNPLVIYGPSGCGKTTLLARVAQCCQQWLPEAFLIVRFIGISAQSSTVEQLLSSITNQCSILNYGHKCHCTHNIETYQKVLPNLLTASCLQRPLIILLDGLDQVRAYSSKNIDWLPTVLPDNIKLIISVSEHSDMHAKISEKLNQDNFIQMPLLGETEAKGILMSSVMQYNHSVNSKIQDCVLKSVQECTIPLYSKVLAWQTSWWVDKEHEIVPKGHVNDQLHQMLEELETILGETQVQHALALLTCTKHSLTDSEMIDLLAFDEHFNTDTTFEKSSLCDVLVSWAPACITWSRINKYLAPFLHWTLTGKVLGIQWKDNLLKEAASERFKEHKNWAHQMLYDYYNGRWWNSKPTSLQARLVVQENILGKCYNRRRLDELPYQHFQLHSNLENSMFLSDTSWIYDKVCGSNCYQILEDINLHPQISNQFTLVLKDFIETHASVLNYDGKQFYSHMYKYLTDKISKNELSIENNDSSLSKVYSVCKSPPVLSLIAINEADSVESDQFLEKTTEEKNFDLVVRLPKTDQFIVTVSTNNKELCVWDIINCQPVRILQGVPHPINLIPIDEFKCIVLCMRELRTFDLNSGSFLTKLKGVMNQKMPYYGLHDQSHLVALSRNRMYINLMNLESGNCVTTFKAGEDRFLNSLLVSGDGRVLVCGDETQKPFPLLVWNLKSRKLLYDLRIPHHHFITALSAITYEGNYVCCVCFEIAEPNPNFIVVYDLQSGTLFKKWKPSCNTVSLEISSQGGCVISGLEDARILVWDLITGNCRWSLSGHTAPVSSLKLDPTGAFCLSRDSECRDRSIRIWDLNKGNLVAVYTPKTKISACEITSNGRFVVLALDGCKKLVTLELKGPGIDETPQSESYGEEENSGKTFVLPENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IP90</accession>
    <name>A0ABM5IP90_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137926.2">
        <property type="nucleotide sequence ID" value="XM_028282125.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282125.2">
        <property type="protein sequence ID" value="XP_028137926.2"/>
        <property type="gene ID" value="LOC114332339"/>
    </dbReference>
    <dbReference type="GeneID" id="114332339"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137926.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="507" mass="58792" checksum="7B8C3EA50DA673F6" modified="2025-10-08" version="1">MACNEDIKDSTNREILTVIKDEGDSLKKYNNIEVKLELNVSSYGQESVLDEFCSVDIKIENNALENVSNEIKAEAKTELEEQSIGAPPDITMELTNNKPFNSTKGHLKTYTGERPYECKICNKLFTTKGNLKIHMKIHTGEKLYKCEICSKQFAQLSSLKDHMRVHTGEKPYKCEIYSKLFTAKCTLNNHMRIHTGEKPYNCEICSKQFTAKCSLNTHMRIHTGEKTYNCEICDKSFVQTSNLNTHMRIHTGKKLYKCEICRKHFTAKSSLNYHIRIHTSEKPYNCEICSKQFTGKCTLNNHMRIHTGEKPYNCEICDKSFVQTSHLNTHMRIHTGEKPYNCEICSKHFTTKSSLNYHIRIHTSEKPYNCEICSKHFTTKSSLNYHIKIHTSEKPYNCEICDKSFVQTSHLNAHMRIHTGEKPYNCEICSKHFTTKSSLNYHIRIHTSEKPYNCEICSKQFTAKCTLNNHMRIHTGEKLYNCELCSKLFTLKGDLKRHMRIHTGKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQ91</accession>
    <name>A0ABM5IQ91_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138667.2">
        <property type="nucleotide sequence ID" value="XM_028282866.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282866.2">
        <property type="protein sequence ID" value="XP_028138667.2"/>
        <property type="gene ID" value="LOC114333042"/>
    </dbReference>
    <dbReference type="GeneID" id="114333042"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138667.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23421" checksum="5E83F032EC82AAD1" modified="2025-10-08" version="1">MVHKCTSRCMFRMVYLSPSFTFSLFVYIDAVSLVPSPDSKIIKEGVAIHFAEKGLNVWFISPSVLDNIPANIVPPDKEILQLITFIYLKDCKDLLNHLNTIHLWHKSPTVILICGFDIYTNIFEENYKPMLAALLSTTLLDSSVVCYKKNKKSTYLILTLQTIPDNYRDRIKVLYDMYFPNIITDQHEEIVIDKVVNYYINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQ98</accession>
    <name>A0ABM5IQ98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028138671.2">
        <property type="nucleotide sequence ID" value="XM_028282870.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138679.2">
        <property type="nucleotide sequence ID" value="XM_028282878.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138685.2">
        <property type="nucleotide sequence ID" value="XM_028282884.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497923.1">
        <property type="nucleotide sequence ID" value="XM_050641966.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282870.2">
        <property type="protein sequence ID" value="XP_028138671.2"/>
        <property type="gene ID" value="LOC114333043"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282878.2">
        <property type="protein sequence ID" value="XP_028138679.2"/>
        <property type="gene ID" value="LOC114333043"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282884.2">
        <property type="protein sequence ID" value="XP_028138685.2"/>
        <property type="gene ID" value="LOC114333043"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641966.1">
        <property type="protein sequence ID" value="XP_050497923.1"/>
        <property type="gene ID" value="LOC114333043"/>
    </dbReference>
    <dbReference type="GeneID" id="114333043"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF147">
        <property type="entry name" value="CGMP-DEPENDENT SERINE_THREONIN PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="9" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="374"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="492"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="634"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="895"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138679.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="945" mass="106159" checksum="F6075B1D336F6AD5" modified="2025-10-08" version="1">MLVHAQKESSPPSNLYNNSKASPKNGNLRGVFKKSHTCGSLFAKCSCGEKFDCKSDHKNFSHSKPIGIQISSKLSLDETCFPRGKRASNPDLHRFSKSPEVCLCPKLPKGTNVVKANVYLPHPEINFPIPVEIPAENCDKCGLNQKNTPPPNLHPEIKNKLDYHKYTALAYEGQSIQNNDEAQKFLQGFGILTPMGNGIASSLRKSSIDGEVIQTIKRSSKNLELKRKSLIDTEDYDYLKSLVAKLKYEVCEIEGKYESVQSELFDVKKLLGCKESQVLKLQREIHKLKSVLQQTNTSSRDGELLANIQKQHSMANGVPQNLLTLNSSNHSKKQGVSAESSEATGEAVNISITKFDKDFRSKQLIKGAIMDNSFLKHLDTSQVREMVDAMYVKEFSAGSLVVKEGETGVHLFVSGEGDFEIIKDGNVLGLMGPGKAFGELAILYNCTRTASIRAVTDVKVWILDRKVFQQIMMRTGLQRLQDNLNFLKSVPLLQNLNNDVLAKIADALEVEFYPAGAYIIRQGASGDIFFIISSGSVKVTQRLPGQLEEDEIRILQRGDYFGEQALLKEDCRTASVIAMHPGVECLTLDRESFKQLIGDISEIREKDYGDVERLNKTSSSLEQQEYEYIKLNDLEVIATLGIGGFGRVELVQYVTNPSLTFALKCLKKQHIVDTQQQEHVQSERSIMMSCRSPFICRLYRSFRDQKYIYMLLEACLGGEVWTILRDRGCFDDHTTRFITACVIEAFEYLHARGIIYRDLKPENLLLDSKGYVKLVDFGFSKRLGYSSKTWTFCGTPEYVAPEVILNKGHDKAVDFWALGILMHELLTGNPPFRASDPMNTYNLILKGIDMIDFARHNVGRTAQGLIKKLCKDIPSERLGCQRGGIVDIKKHKWFQGFDWDGLVAQTLPAPIQQNVRSPCDSSNFDDFPKDGDIPPDELSNWDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISQ1</accession>
    <name>A0ABM5ISQ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140787.2">
        <property type="nucleotide sequence ID" value="XM_028284986.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284986.2">
        <property type="protein sequence ID" value="XP_028140787.2"/>
        <property type="gene ID" value="LOC114334868"/>
    </dbReference>
    <dbReference type="GeneID" id="114334868"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="179"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140787.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="452" mass="52079" checksum="B85B4CA03825821F" modified="2025-10-08" version="1">MVSGTIKHVIHCTCFIGFIILGQVFMVVPSNYTEDWEQCDTVRLIIFWIVKLGTFATIPQLFSSFIGVLIYNSFSDNIIIKGPRLLAPFVCFRVVTRGDFPQLVQNNVQRNIETCLSAGLEHFCFDIVTDNTINISPSRQLKETVVPSTYKTKSGALYKGRALQYCLEENVNFLEDDDWIVHLDEETLLTENSVNGILAFVMDGKHQFGQGVITYANEQIESWITTLIDSIRVADDLGKHKFQLRFFHKMFFSWKGSFMVAQVAAEKDVTFDHGLESSLAEDCFFGFLAREKGYTFDFIEGEMWEKSPFTLTDYIKQRSRWLRGTFQFIMSNHIPGRYKITGCFGCFSWICVPFVAVNGILNFCMLTPYFPICERIHLLLNTIAVYLYFFGVVHSFYRSNLTRIILYFACIVILAPIYIFLESMVVFMFLFTSRNTFQIITKSLEQKQASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISU4</accession>
    <name>A0ABM5ISU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028140883.2">
        <property type="nucleotide sequence ID" value="XM_028285082.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285082.2">
        <property type="protein sequence ID" value="XP_028140883.2"/>
        <property type="gene ID" value="LOC114334945"/>
    </dbReference>
    <dbReference type="GeneID" id="114334945"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="26"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140883.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="472" mass="52367" checksum="BA8DC184A844D25C" modified="2025-10-08" version="1">MKKIDIEEPNIKHEKARSSPWMFHFSLFTANLIVIISGSAMALFSFAYPILTSTNAEVNPLGRPITPFEISIVLTTGASCGALSNVFIGRVLDKFGRKNGIRLFGILFFVANISLAFTRNIYLLVLSFAVQGLTTSSGIITVTIYGCEIAEDRNRGWVGCLSSLMIPVGNMLTFIFGAFINNFSLFNLIFASLALLLVLLSFFIVETPICLSLQGRKEECISTLKKLRYYKNDSGPEKDFYLLQTRSEAEPSQVKFSTLLQDKSTKKALLLCFTILTTQQFSGLFLIMGFIVPRFTDHNSSVSGSTISLIVGAIQIAIIIVILFIVDKIGRRLLILLGSLGCSAMLFILVFYFYVDHMSLPLLNSIKLLPVISITLWIISYTLGLAHLPNILVGELFNNEVRATAIGTIYTVERIIGIVLSFEYPLVTEKFGAHINLLLCSIITLIGFILLLIFLPETRGQSFKKIQSILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUQ4</accession>
    <name>A0ABM5IUQ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Salivary secreted peptide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142640.2">
        <property type="nucleotide sequence ID" value="XM_028286839.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286839.2">
        <property type="protein sequence ID" value="XP_028142640.2"/>
        <property type="gene ID" value="LOC114336466"/>
    </dbReference>
    <dbReference type="GeneID" id="114336466"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411054" description="Salivary secreted peptide" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142640.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13804" checksum="76021EBDE944682E" modified="2025-10-08" version="1">MKKIVCVFFCLFVAFQLVDGYNRSEIREGNCLHIGPHFYYKEYIYRYGFPFITRSATLTYYGNGKIYCIMAITPRDAPKGSTVRIKKGGLNHTFVELEFTSSKHYGFEYIVEVSARYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXF7</accession>
    <name>A0ABM5IXF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147002.2">
        <property type="nucleotide sequence ID" value="XM_028291201.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291201.2">
        <property type="protein sequence ID" value="XP_028147002.2"/>
        <property type="gene ID" value="LOC114340456"/>
    </dbReference>
    <dbReference type="GeneID" id="114340456"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="14">
        <location>
            <begin position="665"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="15">
        <location>
            <begin position="811"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147002.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="955" mass="106228" checksum="0744FBC39782B024" modified="2025-10-08" version="1">MTAVEQPCYTLINLPTDSEPYNEMQLKMDLEKGEVKVKIRALEKIIHMILAGERLPNGFLMTIIRNVLPLQDHLAKKLLLIFWEIVPKTNPEGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPSIRACLDHRHSYVRRNAVLAIFTIYKNFEALIPDAPELISNYLDGEQDMSCKRNAFLMLLHADQERALSYLASCLDQVNSFGDILQLVIVELIYKVCHSNPAERSRFIRCIYNLLNSSSPAVRYEAAGTLVTLSSAPTAVKAAASCYIELIIKESDNNVKLIVLDRLIALKELPNHERILQDLVMDILRVLSAPDLEVRKKTLSLALELVSSRNIEEMVLVLTKEVSKTVDSEHEDTGKYRQLLVRTLHSCSIKFPDIARSVIPVLIEFLSDNNELAATDVLLFLREAIQKFKELQPLIIEKLIETFKDIKLVKVHRAAIWILGEYASTASDIEVIVGEINRLLGEGSLVEAEQKLIAGDTEENAPAPAAGATTLVTSDGTYATQSAFNTVSQTTKEARPPLRQYLMDGDFFIGASLASTLTKLSLRYEDLTSPAASNGFNAKIMLIMAGILHLGKSGLPTKSITNDDKDHILFCLRVLSDRSPIIVEIFKKLCRSALNEMLLAKESVEAISQKSKEKNKRTIQTDDAISFLQLETDKSGELGENVFEMSLSQALVGGRTGGGESVLSSNKLDKITQLTGFSDPVYSEAYVHVNQYDIVLDVLIVNQTNDTLQNCTLELATLGDLKLVEKPQPVVLAPKDFCNIKANVKVASTENGIIFGNIVYDVIGAGSDRNVVVLNDIHIDIMDYIVPASCTDSEFMRMWAEFEWENKVTVNTPLTELSEYLEHLLKSTNLKCLTSEKALSGQCGFMAANLYAKSIFGEDALANLSIEKPFNKPDAPVSGHIRIRAKSQGMALSLGDKVNMTQKSTQHKVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHU8</accession>
    <name>A0ABM5JHU8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497512.1">
        <property type="nucleotide sequence ID" value="XM_050641555.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641555.1">
        <property type="protein sequence ID" value="XP_050497512.1"/>
        <property type="gene ID" value="LOC114342622"/>
    </dbReference>
    <dbReference type="GeneID" id="114342622"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25188" checksum="627885EC14B9DE3C" modified="2025-10-08" version="1">MCEKHFQPHFISKGGNVRKNLFIQAHPTIFPYNQDVQSADEPLRKIIRLETQIEDKTEIDIMQPVANKTDASHSMHSIPDTLMEESLVTDVDVNTEVSTRPHTPAHTVSTQTPPKLSSSSPRKVKLRIKIKTLQKNIRKCKSPKKKKENDNIYLNKFNQMCDKLLNKPLAQIVKAQALLKSKPPKSRRCSYYHLFIIIFIFLVVFCKCGVSKKVNKLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI33</accession>
    <name>A0ABM5JI33_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497597.1">
        <property type="nucleotide sequence ID" value="XM_050641640.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641640.1">
        <property type="protein sequence ID" value="XP_050497597.1"/>
        <property type="gene ID" value="LOC126878760"/>
    </dbReference>
    <dbReference type="GeneID" id="126878760"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF102">
        <property type="entry name" value="RH30783P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="128"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="367" mass="41048" checksum="57AF40BC6F8AD894" modified="2025-10-08" version="1">MQSEPSTRYIHSVSDLLYTTDEIEFLLDDIRDLEPKNYKPEDIQDPDGGMSCVLQDFEIAGSRTGALSSAGGAAECTGAASECAGGCECESPLGTVNSWDSHSHYRRNPPSPDLSLYSGVILYCDHTHLRTSTGFFRLLLLATSIACLACLCTSGTLKVGLFMLPSIGRIRFMMFITLLSMFTTCLLLFLDISHIVYLFPFNWGKVNAYFYVSLSVLFLIASSLLFHMIFSIELPKWTHHQLLVTGCLGYVCSIESAIISVIQKCQMAQYEPVEEDLSFHLQERPFSPKDSPQHNKVNQTTHNYKPIVNYSNPSVELQLRRSSYARVVVEERILAQVVPSTSKQDPMNYLDDIQPCSSKSGDPYRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI65</accession>
    <name>A0ABM5JI65_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497631.1">
        <property type="nucleotide sequence ID" value="XM_050641674.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641674.1">
        <property type="protein sequence ID" value="XP_050497631.1"/>
        <property type="gene ID" value="LOC126878777"/>
    </dbReference>
    <dbReference type="GeneID" id="126878777"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047395975" evidence="3">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="365" mass="42635" checksum="50F7CDAD568B1E5F" modified="2025-10-08" version="1">MKCLIKLLVIVRFISPILSDCLQIIDNGKNWTVIVPTYRAYAIGDEYKNFFNVAEKISTYCHIKENCNVPIDPIMNLNKEFYRNNFRHVVRQYLKENNLEFTNVTSLPLKEYAKLLIMLDKTGFDQGYYIDTIKGFFVLWNPLQDRGYFCYEGPATESVLNTNQSVHYLTFLNQNVEITLEQSEMKMVYTWNTKIDYVFLRYGINCFLPISFSNLTSLLMLNLPPTPPQCNNTYLTNIIIISSLCFVLVILIIVYFTRRHAISAYLFSNCCRKNQLEARGSSYRTQTIKNDQMDSYVEPLEVHTYSQPDTRQEKFYDLQGNRIPIEINEQNQSKPEYDYAYSHKNPSNISEGNISNTTDTIRAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJM8</accession>
    <name>A0ABM5JJM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_050498141.1">
        <property type="nucleotide sequence ID" value="XM_050642184.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642184.1">
        <property type="protein sequence ID" value="XP_050498141.1"/>
        <property type="gene ID" value="LOC126879167"/>
    </dbReference>
    <dbReference type="GeneID" id="126879167"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="279"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="523"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="757"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="930"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="624"/>
            <end position="626"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="631"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115322" checksum="D5DF7B2389463B95" modified="2025-10-08" version="1">MVRKKIDNRLRVLIENGVKLGHRTLFAIVGDKGRDQVVILHHMLAKAEVKARPSVLWCYKKELGFSSHRKKRMKQVQHKIQAGKLNVNEDDPFELFLASTKIRFCYYSETHKILGNTFGMCVLQDFEALTPNLLARTIETVEGGGLVVLLLRSVNSLKQLYTMSMDVHQRFRTEAHQDVVCRFNERFLLSLASCKRCLVVDDQLTVLPISSHNLHVAPVENVQEVDESTTELNDLKEQLRDTQPVGNLVNLCKTLDQGKALLKFIESISEKTLRSTVSLTASRGRGKSAALGLAVSAAVAFGYSNIFVTSPSPENLNTFFEFVFKGFDALEYQEHIDYGLVQSTNPEFNKAIIRVNVFRDHRQTIQYIHPTDSHRLSQAELLVIDEAAAIPLPYVKAMLGPYLVFLASTINGYEGTGRSLSLKLLNQLRIQAAPIGANTNAVNKKDSGAATGRTLHEVTLNESIRYKPGDDVETWLVKLLCLDSTSVSPILSGCPPPDSCDLYYINRDTLFCYHKASEEFLQRLVALYVASHYKNTPNDLQMMSDAPAHHLFCLLGPVDPKKRTLPEVLVIIQVCLEGEISKNSILDGFSRGKRAAGDLIPWTIGQQYQDADFPKLAGARIVRIATHPDYQGMGYGARALDILKQYYEFKIPSLDEDSQLPKQEIDNVEDSEVGLLEETVEPRNSLPPLLFKLSERPPEKLDYLGVSFGLTEQLMKFWKKAGYIPVYLRQTTNDLTGEHSCIMLNVLNTEEVKETDWLAAYWTDFRRRFVNLLAYQFCKFSPSLSLGVLSNKAVKLRTKDLTKTELDIHFMKYDLKRLEMYSNNLVDYHLIMDLMPTLARLYFLNQLGSIQMSAVQSAILLGLGLQHKTVDDLATELDLPSTQLLGLFNRLIRRLSQYLNGALEEDIERKLAPRKDAEDLKMTPFPQSVQDELEQAAKELKKKQKKELEKLKNENLEQYAIKGGEGEWSKVLTGKGKKSIVTVKSGEKRLHETNNTEGEETEVKVKKKKFKNKNKNRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKX6</accession>
    <name>A0ABM5JKX6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498591.1">
        <property type="nucleotide sequence ID" value="XM_050642634.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642634.1">
        <property type="protein sequence ID" value="XP_050498591.1"/>
        <property type="gene ID" value="LOC126879530"/>
    </dbReference>
    <dbReference type="GeneID" id="126879530"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="404" mass="47242" checksum="AF251A5CF10E2713" modified="2025-10-08" version="1">MEINQEASEETCKIKVEDTCVGSSFDVCKIEINEEPKREPVYDAFIDYLDSNEFSIDTKVEQDEYKFSLVEEKQTTNEESCPQEGNKMEIMETSYSSHKGKYTDQDAGRKILNKSMKVGTENRLYKCEICFKQFTTKGILKTHLRVHTEEKPYKCEICFKQFIRADVLKTHLRVHTGEKSYKCEICFKQCGQAGDLKTHLRVHTGEKPYKCETCFKQFGKTDTLKKHLRVHTGEKPYKCETCFKQFGRAGSLKNHLRVHTGEKPYKCAICLKQFTMEHSLKIHLRMHTGEKPYRCETCFKQFGKTDTLKKHLRVHTGEKPYKCEICFKQFGQAGDLKTHLRLHTGVKPYMCEICFKQFNITGDLKKHLRVHTGEKPYKCEICFKLFSQKSNLKPHLRTHTEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLT7</accession>
    <name>A0ABM5JLT7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498900.1">
        <property type="nucleotide sequence ID" value="XM_050642943.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642943.1">
        <property type="protein sequence ID" value="XP_050498900.1"/>
        <property type="gene ID" value="LOC114329172"/>
    </dbReference>
    <dbReference type="GeneID" id="114329172"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23316">
        <property type="entry name" value="Ig_DLEC1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1529" mass="176621" checksum="1307FB2E6042248F" modified="2025-10-08" version="1">MDAPFCSLENSTHNEVAPSLKTALQETLDEFIYHRDDGKLYVQYSFTSEEDFFNEIDVSVHNVLNKTKGDMAKIDLAAKDILIQKDNYLVEKEKIDNCCELRETIKLKPCHLFKTLETEFTAEYNLIQPEDMPTLFHSYLDEKNKDHHICPACAKRETSTIVKRKEKQKQRQFQKYTVTLVKSYTDSYKVIPNYVVFNNYTVGEIYQENIKIINTSRTIQAIGLENFPKCPYFSIIFKKNEKIAPGMSVTATITFKPKKYKTVTDTIRFKNNTGEIVEVQIIATRDVPKLITCIFKSSNANLLASDNLKHGFKEKRREALNSTIDCGSCLVSQYVLVSMILENRGITGKFFFITEDDWFFQNINDVSSCMELFKGDFWIYPTYFEVCNQEIVEVNIIFQPTKLGLHAETLYLMCDNNTFQEIELLGDAVEFSKDLIEIKVPPEVTEISSKQNYTVFFGHTFKETVKSFNVMVKNKSSVCLSCEWRFKHKNSKNVVNLPQDWIIQKKVNSILKPYSTTEFEFDIHLIPEKIGYHSIFFCFYTTNIPCISLKENEDFLVIERINFCGKTLTKAVDVLISQIEVCVLIQLDENETRCLCDESEQSPQCNQMMCFSDPVLNFGILPSGIDVQKEFEIINGSGQNLSWQIWEIKYDIDCQPHLQINKESDNLSETYGTCDACEGYKLLYKICNQGVQSYVSFLVLISITDQNIAVVEDICVITYEIIDFNIKITSKYISVPILYAAEIIYSGIPTDLELFVENLSPITGYFQFLGPIGDDATKMIIELSPSSSVIRPYETITIRVKLTCMETGFFQDTYIPCFIGLGQEPVIVKVICAVDGPRVIYHLPRDNKNFKNIVWPPLFHYNYGLEIGQGDERLIHEEYNNSAYESDKATEDLNQDMIKLNFTTHEHEFKLPLECKNSCKSTEGEEDFQKKSSTSVFSGIENQNLEYTLRQGSEESLFLHEDVVEIHNIQILSARRISIYIENISPIAVTYNIKLRNFYYNKNFDHTAVRQKLKNIVDLCKSAPHGIIIQPDIQEDQIKGYCALRIDFWIYANTFGIYTEEIIVEISEVPDYHFSMIIEVVGCPVQIPLGLNCITKYPTIRFGSVAFQSANINRKIKIINVSAIPIQIIWYPFNNKLNEKYIHEEEPFTILFHMSGDCCSEIIGEIVVLDKFFGEYSGAFCDVEQRETYINPHSEAYINICINPTYFKEESEGINIMNYLVGLIQVDSKYMKYANYYYRKLDPNVHQVQIQVQTRLEIPTLQLDFSEQNKNFLHVYANDILLKNQYDHHKYVVLRNTSGVECEVDIYVECPFYFKKSKKERSDRMTMVSTGGSAREVHMYCQFTPNDILDLSSLIYSTEKENSNTRNQKGIINEEKAYTKDDENKIIHINKTLTLSYRQHVKKFPMKIIIHYPNISVTPTFVDYSNVLLNQANKNMITVFNHTGCVVKFEITKSKNANSFVITPHYGEIPPSTGNLKQYVNIFIYFCATECKKYSESLRIVTNIPDYFIEVPLKGVGSINEKFCINYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNE5</accession>
    <name>A0ABM5JNE5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499460.1">
        <property type="nucleotide sequence ID" value="XM_050643503.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643503.1">
        <property type="protein sequence ID" value="XP_050499460.1"/>
        <property type="gene ID" value="LOC114332930"/>
    </dbReference>
    <dbReference type="GeneID" id="114332930"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF66">
        <property type="entry name" value="BCDNA.GH12326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="95"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="339" mass="38816" checksum="02015763D5E4F216" modified="2025-10-08" version="1">MKTKPGYLSTASFKKEHKRLSSLVPYILLSIIALVVSIVIVSDLHWEEHVSINRGFVIFFSGLVFFPSLYLALVNTILYTNSGRRIIKTYKLNYSDVYDISNKHVSAVQALFCCITGITAICYSCNRNVLRTSHYISEAYAWFGAAYFFYDIWSMYKVYSAKLSSDHMNGDVKEKKKMFLNVSKWIRYLKNNFVIVGHHIFIGCFGFLVITYLRGGLGDCFFGFVYLMEASTPFVSLRGVLSKIGMKNSPMYVINGLVMLAVFFICRIAMFPYVIYMYAESIKVDFMSAVYTLPRGCIISIMVLLLPQLYWFYLMVTGATKVLRRPVVNNNNTKNLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNE6</accession>
    <name>A0ABM5JNE6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499461.1">
        <property type="nucleotide sequence ID" value="XM_050643504.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643504.1">
        <property type="protein sequence ID" value="XP_050499461.1"/>
        <property type="gene ID" value="LOC126879997"/>
    </dbReference>
    <dbReference type="GeneID" id="126879997"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="103" mass="11381" checksum="DF3EB26393BD208C" modified="2025-10-08" version="1">MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPA6</accession>
    <name>A0ABM5JPA6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499777.1">
        <property type="nucleotide sequence ID" value="XM_050643820.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643820.1">
        <property type="protein sequence ID" value="XP_050499777.1"/>
        <property type="gene ID" value="LOC114331606"/>
    </dbReference>
    <dbReference type="GeneID" id="114331606"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="491" mass="54381" checksum="F9478CB23D86329F" modified="2025-10-08" version="1">MAGVIMLSESEADSNQTVDTIEKDCNGIVINNGDSIEGCNGGGGNGSASDSGDQMDAEARERELVRRKEEAKRRRRKKKRTGSSLVSSCFQDLYKLTGEVLGEGAYASVQTCVSLFTDQEFAVKIIDKVPGHARARVFREVETFHHCQGHPNIIQLMEFFEDEEKFYLVFEKINGGQLLRRIQEHKFFSEAAAAEIVREVASALQFMHAKGIAHRDLKPENILCVHRDQLCPVKICDFDLGSGIRFQSSVSSPLATPQLLTPVGSAEFMAPEVVEAFIGESETTSYDKRCDLWSLGVIMYILLCGYPPFYGKCGRDCGWERGDNCNACQELLFQSIQEGRYDFPEPEWTTISDEARDLISSLLVKNASERISAEKVLQHPWLQCASDTAALTTPAVIKKNNSALELSQFAESAMAVNRVVQQHFSMKLDYLERPNVYPDCPVRSGMKTCASAKMFGLSPPSESNLMRRRIKGGSCQFLVPAPTPAIPSPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPQ0</accession>
    <name>A0ABM5JPQ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499916.1">
        <property type="nucleotide sequence ID" value="XM_050643959.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643959.1">
        <property type="protein sequence ID" value="XP_050499916.1"/>
        <property type="gene ID" value="LOC126880184"/>
    </dbReference>
    <dbReference type="GeneID" id="126880184"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="184"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="383" mass="43227" checksum="41E1F533AE2630C2" modified="2025-10-08" version="1">MAWTQRQLLIAVFMIITGSINTLSTKWADTLKSRGRDGEVKNFNHPFFQASSMFLGEFCCLLAFKFFYRKFSKRNDGTEDVHDLTKGNRHFNPLILFIPAMCDMMATSIMYIGLNLTFVSSFQMFRGSVIVFVGLLSTGFLERMLNKSQWSGIFFVILGLAIVGITDFVYHDNNGSHGRNDIITGDMLIIIAQIIQAVQMVVEEKFVAGQDIPPLQAVGWEGVFGFTVLALLQIPFYFIRAGPPVTMNPGDRLEDAIDAFVQIGNNWRLALAVLGTVVSIAFFNFTGISVTKELSATTRMVLDSVRTIVVWVFSLAFFGQKFHFLQLFGFNLLIMGMCLYNGISPIAIFIKIFLKIKSLFTSRRYNSMEEEIIENRNAEDTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS34</accession>
    <name>A0ABM5JS34_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050500740.1">
        <property type="nucleotide sequence ID" value="XM_050644783.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644783.1">
        <property type="protein sequence ID" value="XP_050500740.1"/>
        <property type="gene ID" value="LOC126880736"/>
    </dbReference>
    <dbReference type="GeneID" id="126880736"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="12"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="490" mass="55148" checksum="3B248BF5EE7B9D26" modified="2025-10-08" version="1">MWHLCGNIMELPKEPEPWDNILDTTKNTKICYQTISRFDFLKIEEDCLYINVYSPQKPGSDDLLPVLLWIHGGGLVNESSTIEYYGPKYIMDHGVVVVTFNYRLGPFGFLGTDDGVIPQNLGLKDQRFAIEWVNQNIHLFGGNPEHVVLVGESAGSLSVGLHLMGDWEGGKELFHGVIMQSGTPISGICTTQHPTEQTFRLGKKVDPSFDSKSSEELLQVLQSASAHDILWAGIPGGAVLESSGPFSYPAYQAFIDQNYKKVPVIIGFNSEEWLYLALMNNEEVLKAYDANPSSLVSGLMTMTPENRTIAGNLLKDLYTNNGSFVDDLGGYIRSTSDNLFTTSTCKQVELASEVVPYFFYQFSYKGELGQGMGLLPVAPPDVGGTVAHAEDLHYMWEEQGTNSDLSKYSAEDQLMLHRYVTLWTNFIKYLDPTPKPYSLLSNFTWSPSNKETLRYMNFKLDLEMSEHPRQYSQVKEIKEKYMEPPYVVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU46</accession>
    <name>A0ABM5JU46_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501459.1">
        <property type="nucleotide sequence ID" value="XM_050645502.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645502.1">
        <property type="protein sequence ID" value="XP_050501459.1"/>
        <property type="gene ID" value="LOC126881300"/>
    </dbReference>
    <dbReference type="GeneID" id="126881300"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="483" mass="57701" checksum="D19C1EF5493C0A15" modified="2025-10-08" version="1">MLTEDKSQIFNVLLNGENAFIKSRTSKNNNTKKVINQNFKQEEHVSNHEEETKEKKYSLPSKQFSIRESFILQLFEQNKTLNTIYNIFVANYVIFIFAYTLKEYMNHQRLPKALLIIPRSFGKMHLVALVWLGNNFATFSTYYFFLLWGKTRQKVIFRKLWDALWILLLITYYMMSFVVITKVVFALNLPFASAVIITMESVRFLMKVHAFVRHNAPKMLHNSNDKTTLLSFSRFIYFLYIPTIIYRDQYPRLKKIRWGFVFFRLFEIANIIIFLAYWYEYVITPYFKESCLKTWSALEVFLLFIEFCIPAYVIIWLMFFTVLHSIQNAVGELLRFGDRLFYADWWNCTNVQQYYKKWNMVIGDWLYTYIYKDMYEIISPGNRNLGKIVTVLISALVHEWICTVSTGYFLPLHIPLMTFSTICMYAFRVKEYSTANNIVYIIMIMLGSNIIITFYAFEHFTRLNFPSNKQFVSLFWTNNCVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUP0</accession>
    <name>A0ABM5JUP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501658.1">
        <property type="nucleotide sequence ID" value="XM_050645701.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501659.1">
        <property type="nucleotide sequence ID" value="XM_050645702.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645701.1">
        <property type="protein sequence ID" value="XP_050501658.1"/>
        <property type="gene ID" value="LOC126881428"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645702.1">
        <property type="protein sequence ID" value="XP_050501659.1"/>
        <property type="gene ID" value="LOC126881428"/>
    </dbReference>
    <dbReference type="GeneID" id="126881428"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="613" mass="71513" checksum="E5ED5B1C2D3FF656" modified="2025-10-08" version="1">MFNQTEVKKEVGETTCKREIDNEVDDVLQETLKTEIKEEPMDEITNDTFDYVDIKTCPIKTEIEQDDGFSCKDMKTDASGRSILNQHITSTTNVKTGGQPFICIICKKPWSTNYRLDIHMRIHTGEKPFACEICTKRFSTNGHLKIHLKVHTGEKRFKCETCNKQFSTKQILKSHVRVHTGEDPFECEICNKQYSTQSNLKMHMKLHIDEKPFECGLCTKQFSRKHNLTKHMRVHIKGECTGEKLFECESCNKQFSTKDNLKSHMKLHTGEKPFECEICTKQFSTKSSLKAHMMVHTGEKSFECKICTKQMSTKEVLKLHIMRVHTGEKPFECGICTKQFSTKGSLTVHMTVHTGEKPFKCEICTRQFSTKEVLRSHVRVHTGEKPFECQICAMKFSRKCYLTIHMQSHTGEKKFFECEICTKKFARKRYLTIHMKMHTDEKPFECGICIKQFVTKQILQRHMAVHTGEKPFECEICTRQFSTKIVLRSHVRVHTGEKPFECKICAMKFSRKSYLTIHMISHTGEKPIFECEICTKKFSRKSYLTIHMKIHTDEKPFECGICNKQFIAKQVLQRHMAVHTGEKPFRCEICTKKFSTKYVLKSHMRVHTGEKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JV29</accession>
    <name>A0ABM5JV29_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tumor protein p53-inducible protein 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501798.1">
        <property type="nucleotide sequence ID" value="XM_050645841.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645841.1">
        <property type="protein sequence ID" value="XP_050501798.1"/>
        <property type="gene ID" value="LOC114332178"/>
    </dbReference>
    <dbReference type="GeneID" id="114332178"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045821883" description="Tumor protein p53-inducible protein 13" evidence="1">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31756" checksum="A6471FBCDD5BA408" modified="2025-10-08" version="1">MLKNIIVLCLAFFHSSGMKYNENTNRWEGNWFPHSPNELDQNPVVQLKGSNNVDNKHGVIMGIRNPECDDAKTNLTLDWDMNPTNYTCFGGKDLYEPNSYIHPVHSYEYIPASYNAQHKCMDESIEYSEIVPTFGTHRPLWPKYGEYKFVPRQRWIHNLEHGAVVMLYHPCANKNEVNLLKEIVRGCLFKHVITPYNLLSPNRPLALLTWGHRLEMSKISKSLVVRFIRDHAHRGPEDTFKDGQYDFYLTRPAKIVSGFKDSNLCPTERDIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXD6</accession>
    <name>A0ABM5JXD6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502600.1">
        <property type="nucleotide sequence ID" value="XM_050646643.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646643.1">
        <property type="protein sequence ID" value="XP_050502600.1"/>
        <property type="gene ID" value="LOC126881913"/>
    </dbReference>
    <dbReference type="GeneID" id="126881913"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45842" checksum="DAFABA61FFEA3628" modified="2025-10-08" version="1">MDSEGRKVIVCDNGTGFVKCGYAGSNFPAYIFPSMVGRPIIRAVNKIGDIEVKGLHVDGVASTLPDLMVGDEASALRSLLEVNYPMENGVVRNWEDMCHVWDYTFGPKKMDLNPRDTKILLTEPPMNPTKNREKMIEVMFEKYGFAGAYVAIQAVLTLYAQGLLSGVVVDSGDGVTHICPVYEEYALPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMMKEKLCYIGYDIETEQRLALETTVLVEPYTLPDGRIIKVGGERFEAPEALFQPHLINVEGQGIAELVFNTIQAADIDMRPELYKHIVLSGGSTMYPGLPSRLEREIKQLYIERVLKNDIEKLNKFKIRIEDPPRRKDMVFIGGAVLAEVMKDRDAFWLSKQEYEEQGLKILKKLGARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY44</accession>
    <name>A0ABM5JY44_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502862.1">
        <property type="nucleotide sequence ID" value="XM_050646905.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517120.1">
        <property type="nucleotide sequence ID" value="XM_050661163.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646905.1">
        <property type="protein sequence ID" value="XP_050502862.1"/>
        <property type="gene ID" value="LOC126882075"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661163.1">
        <property type="protein sequence ID" value="XP_050517120.1"/>
        <property type="gene ID" value="LOC126891840"/>
    </dbReference>
    <dbReference type="GeneID" id="126882075"/>
    <dbReference type="GeneID" id="126891840"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="166" mass="19559" checksum="1D74FA81D3D3B45A" modified="2025-10-08" version="1">MAIFDDRIERVEKIRMAQKIMECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0S1</accession>
    <name>A0ABM5K0S1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503788.1">
        <property type="nucleotide sequence ID" value="XM_050647831.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647831.1">
        <property type="protein sequence ID" value="XP_050503788.1"/>
        <property type="gene ID" value="LOC126882788"/>
    </dbReference>
    <dbReference type="GeneID" id="126882788"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12612" checksum="FA335B281426DE66" modified="2025-10-08" version="1">MAGRHFRKKYFDFNKPEDVKALMNIINDYSELEGFSDDSDSDLTWCKELNSLPKSLGDSDSSDSDQEEDTRVNSLIQNKNPPFQNDTEVPGPSGISAAPVLDQPQTTEDLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K422</accession>
    <name>A0ABM5K422_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504943.1">
        <property type="nucleotide sequence ID" value="XM_050648986.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648986.1">
        <property type="protein sequence ID" value="XP_050504943.1"/>
        <property type="gene ID" value="LOC126883439"/>
    </dbReference>
    <dbReference type="GeneID" id="126883439"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="397" mass="45202" checksum="6D763F9E3CB5619A" modified="2025-10-08" version="1">MSICNSKWEEKAYIETNWEQGGLRETVEKKTCLIVTKKDAKDKGVENIIKDAGEDLAETLEEVNEGEIKFLENFRRKENKKTIWYTFVAGIEKESGGDIYDLAEKAITKIKKEMDETPKVVRVVAGNDLNKEIIRKALEYVGRRESISWEMIVRGKELEVEKKSEQEEALLIKMGGKKYNEVLSEMREKIDIGKIGLQVEKLKRTNGGDLLVKLKGRGAAEKLRAELDSKMNGMDTAIRRKETFFTITRLDPGVGEETLKKMIKSYTGVPEREIEVKVLRTNRYGEQVATIAVRPSIAEELRRYGSIKIGWVVCPIMERHNPVRCFKCLKFGHNTYECKEESRAACCYNCLQTGHTVASCGNKPYCSVCKEEGHRMDRMACPSYRALVYGRGGEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K544</accession>
    <name>A0ABM5K544_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505310.1">
        <property type="nucleotide sequence ID" value="XM_050649353.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649353.1">
        <property type="protein sequence ID" value="XP_050505310.1"/>
        <property type="gene ID" value="LOC126883692"/>
    </dbReference>
    <dbReference type="GeneID" id="126883692"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF33">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38610" checksum="834C01D43EC3959E" modified="2025-10-08" version="1">MSSYKHKSGALKRKLQKEKLEQSAKGRQDIKKFFKSNEKEELQEFQPDFNPEPTSASQTQPSSASIQNASTSTVCEGSNDECASADPNLSKDTVDDNKTFNFDDPNTWPAVMSDKIVLCYGGFQAFQARSKSFPADPSGKHFHETLLYMKTDNRTCKAIPREWLMWSETKNSIHCLPCSIFHSNQNKSKLAKEGFFSEKQQYKRLYRLFSMHERSSEHRKHYLEWKSLQISLKGHGVDSNLQQIINCEATRWKAILQRILDTTIFLSSRGLAFQGENTQIGDVHNGNFLGVLELIGKYDEVTREHLAKVKENQLNKKNQVIRFESDLKHDAVWMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5S1</accession>
    <name>A0ABM5K5S1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505540.1">
        <property type="nucleotide sequence ID" value="XM_050649583.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649583.1">
        <property type="protein sequence ID" value="XP_050505540.1"/>
        <property type="gene ID" value="LOC114335351"/>
    </dbReference>
    <dbReference type="GeneID" id="114335351"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF136">
        <property type="entry name" value="GH06673P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045743690" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="307" mass="34086" checksum="BB0A42EC317CFC49" modified="2025-10-08" version="1">MKTANFLTCILCVYLNIAKGNSQDSPPGAIANEMCKIYTENAKKNGNCPIPLFTSVNLISRDKFAETGEFPHMVQVGYKGDNGTEWHVSGFIVSKNYVLTVAHGAEPEWRDPPEIVRAGVTDQADLSKAQTRTIESIIVHPEYKPLVKYNDIALFKVKEDFIFNKFVSPICLHTNEENPDIEGIHSGWGATKYLDERPTHMVKVIVDFDSNESCNKTYRRQVPEYLPQGIVNNKLVCAGGSTLDGCQADSGGPLQIYRRDESGTACMYDAVGISSFGIACGIAKLPSAFTRVSHYIPWIEEIVWPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7P5</accession>
    <name>A0ABM5K7P5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="RefSeq" id="XP_050506208.1">
        <property type="nucleotide sequence ID" value="XM_050650251.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650251.1">
        <property type="protein sequence ID" value="XP_050506208.1"/>
        <property type="gene ID" value="LOC126884313"/>
    </dbReference>
    <dbReference type="GeneID" id="126884313"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="17">
        <location>
            <begin position="1521"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1927"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1927"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1938"/>
            <end position="1949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2225" mass="255590" checksum="D53230A627387385" modified="2025-10-08" version="1">MVLQNSGKYRADRFEKSENNAEGIEIVNREDSSEFRIRQVIENDAIDAKYGFERIKNQQERTGFLLNMHSTEVLDEDKRLFAAVDYYFMEEDGTRFKVSYPFMPYFYVLTHRELLQEVIEFLTKKFTGVIAKVDILAKEDLDMANHLIGLKQKYIKLSFVNQTDLMKVRKEILKNVRKNRQKDHSNTFYTEMLTSTLANSNAQSSFHSNKNIDQMENILDIREYDVPYHVRVSIDLKIFCGSWYTITCKGKDSPPVITLRNDIIERPEPIVLAFDIETTKLPLKFPDSATDQIIMISYMIDGQGYLITNREILSADIEDFEYTPKPEYEGKFTIFNESNEMCLVQKFFDHILEIRPHIFVTYNGDFFDWPFVEARAASYNLDMKQEIGFSRNKEGIYVCRPAMHMDCLCWVKRDSYLPVGSQNLKAVAKAKLRYDPVELDPEEMCPLAASQPQVLSNYSVSDAVATYYLYMQYVHPFIFALCTIIPCEPDEVLRKGSGTLCESLLMVEAFHANIIFPNKQESELNKLTQDGHVLQQETYVGGHVEALESGVFRADIPCRFRIVPDAIDSLVSKIYKTLEHAIVIEEGVPMECVTNLEEVADDIKAKLLALKSSPMRLERPLIYHLDVGAMYPNIILTNRLQPCAMVDETICAACDYNRPGALCQRNMAWMMREEYMPASKNEYHRIQQQLETEKFPPAVPGGPPRAFHQLSKLDQADYEKKRLTVYCRKVYKKLKCTRVEERTTTICQKENSFYVDTVRAFRDRRYEYKGLSKKAKQAVSDAVKGGDASEIKSAKNREVLYDSLQLAHKCILNSFYGYVMRRGARWHSMEMAGIVCFTGANIIMKAREIIEQVGRPLELDTDGIWCILPASFPENFTVLTNHDKKKKFNISYPNTVLNAMVKEYFTNDQYHDLKNPETLEYEIRQENSIFFEVDGPYKAMVLPASKEEGKKLKKRYAVFNFDGSLAELKGFEVKRRGELQLIKNFQSSVFEAFLKGDTLETCYAAVAQIADYWLDVLFSKGKNLPDSELFDLIAENKSMSKKLEDYGAQKSTSISTAKRLAEFLGDQMVKDAGLACKYVISRKPDGAPVTERAIPLAIFQAEETIQKHYLRKWLRDNSINEINIRDILDWSYYIERLGGTIQKIITIPAAMQGVPNPVPRVRHPDWLHKRILEKNDNFKQRRISDMFSAVPKSKSIENDPSNSNQSGGTCEIEDMCMDKNNSSFKAPLVATVTKRKRGSDKENQYTEDELNRTWREVLGNPPLVGKTKSEITAWIAFQKKKWEFQYLQKHSGSKNKKMKTNQKLAVLRSSASGTLGNFLQRAQVVVVTTPWQVIQIAETTISGQFRLWALIQNELYLLKLIVPRIFYANLRTKKAQEEGAVFKTCNRTLPRARQVHNLYLYSIPEEVYQEHGKKLIMDQADPNVEGVYETQVTSIFRALVEIGCVCKVTSRGSSMDTFNLEQLEKVNISRTYLEHGSLRHVYFYHHKHASKYQHMFALFLTPIKKALIIVVDTVKTNLLPNMSNLYQAERLVKLEKNPDTDLLPPGELTFEIKIETDMAKVYKILQKTLQSYKDEKKGPTLLAIQSAIEIGELQHNISNLMDFPQVQIHVQDIEELYNVIDWQKVGARAIVRHYLNSEKVLELMTEQSRYFQLPLGNMPSDPAIFGSDLFFSRHLMKHNHVLWFSTTDKPDLGGSQENDARLLAENQEDSSEVCNVPGWYSSICVELDIDSLAINTLLQSHRVTDIEGTSNITSFDASEITSIDNMISGNQNQTCYDESSRCAESFKILRAMAVAWMRDISMHKNVFADFQVIHFYRWMRSPKAYLYDPALLRTLQNLMKKLFLQLVAEFKRLGCMILYANFNKIIICSKKTTVEDAISNVEFVVASIRSKELFHSLEITYRQCWEQLVWLDPANFGGIKGKLPKGIENDSFDKSNDENETENDDEEEEPVVEMKWNITELLPERGNCRNYFNAVIAGCINAIYTKLKQQERSTISKEILSQPSFGLAQHESVVTYAKELLAGEISQTLFQMTEKIHNRLPPMSDGSSAALEFVKAICHIISLDPALREPVDTLKSNLLRLIGIGEFSEKAVWKDTTVSYVIPQIICKACNHCRDIDLGRDQYRSDSAWICPLCNSEYDNTEIECIILNIINKKLLAYNLQDLQCKKCANIKLDNINRHCTCSADFKCLISKTELIKLLETFYSLAQTFNMVVVSETVKNILSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K962</accession>
    <name>A0ABM5K962_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506726.1">
        <property type="nucleotide sequence ID" value="XM_050650769.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506727.1">
        <property type="nucleotide sequence ID" value="XM_050650770.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506728.1">
        <property type="nucleotide sequence ID" value="XM_050650771.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650769.1">
        <property type="protein sequence ID" value="XP_050506726.1"/>
        <property type="gene ID" value="LOC126884693"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650770.1">
        <property type="protein sequence ID" value="XP_050506727.1"/>
        <property type="gene ID" value="LOC126884693"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650771.1">
        <property type="protein sequence ID" value="XP_050506728.1"/>
        <property type="gene ID" value="LOC126884693"/>
    </dbReference>
    <dbReference type="GeneID" id="126884693"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21865">
        <property type="entry name" value="DEUBAD_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2430">
        <property type="entry name" value="NFRKB winged helix-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025220">
        <property type="entry name" value="NFRKB_WH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038106">
        <property type="entry name" value="NFRKB_winged_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14465">
        <property type="entry name" value="WHD_1st_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEUBAD" evidence="4">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1529"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1529"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1552" mass="171520" checksum="BB7D599CA1DCCA93" modified="2025-10-08" version="1">MDNSSSEDSSSSDYSTESSEDDGMEMAQIGNIKLQLPQGLCEKQDIFKEILSTETWNSLSEENRQHLQTFLPNFPVDDELEKTKTLQRLFDFEVFKFSSPLVKFHDDLKAGYFRPDIAHMRKIIKKAEKKEAKYRYKVFRKQLKNDVLESHNKLLSQIKNLPPGMDPKQEKKKTNVDYVSYRTKRRYFQILQSIKLKTDDTGCSSDENYPEGPPSSLSRKQKRHLNSIRNSINNSKEQYYSSTMLTKLNSFPVDLERYITPNFNPFYINDDSYKSMICQHKKRKLEQLNDPELNTKGITLTDIISRTQLPYNKNMTVITKHQVENKLISKKKIKREFRKSSEHMFSNSNKIKSHYDHSSNSDSDSDSLIDAMSSSSSKPRSKSKSSTSRRTPTPKIKVEIKSEPYSPTLSATSTFTNVPTTSSSNVFQQPVNSITQYGKITPACVEDLDGIDVMNIPIDLDNSDIDILELSNKPELMQDTHANFFSLIRDVICSTCDHRMNMYTLQERLKAWQENPISPLNDWYSYTDNWIGILPSAITFLCGNASEQPDDFVPYMEYKANLDVYQWIGAGRDSDQLLSTLCSFWLEHKSESKEMSVIKEELDVDITDRSSSPPPPRFPTSWTVRKAAPEEIRDFREQERRRYDNPHKAFTYRCHSYESVVGPIKGIYNPAVGNSKAREHTMLSADRPNFVTILSLVRDAAARLPNGEGTRAEICELLKSSQYISSTAPDNVLQSVVSGALDRMHTQWDPCVKYDPKKKIWIYLHRNRTEEDFERIHQQYQGINKSSKKVQKKPSTKTKAKQSPEKPTKTVKTEPSSTAPPAPLQPPPKPVRRASVTQVSPQKITAPTTQVQNHPLPSLITVSAPQKGTSLLLSNNLPKPQVQVQETVLQTKPVISDEPPPLAAASNVTLKPKDEKDVNKPYQTIIHNRVSSPTLKTGKGLVKILSPSQGKSLIIPTSNAQLIKQIQEHRTTPTKQLGQVVTQQLLQTLTAQQKQILVQKQNPSDGSDSQQEKIKVPANMQQQILHLQNIKNVTLLRASPTGNVGLSPLTTASGESPIDQANIMTVAVPKSDQLIGQSGLQIKTQGNLSQAQQQQILQTIKQKILPNASLLANPQQIILKQKSGLINVQKSGIVPVTTQVVGQQKLSTDLSKQSSSTQGPVVAKVLTNAAGHVISVEGLLPQQKPTSILAQGATLRVSGSKTGQQNLIHLTGTSKANALTQLTVGSQNNILTLTTQPKFVVASQTTTVTSSTTSSKSASRSSNKAQTLTKLNTKGNQQLINTKLIQALDGQKSKLVVNQQNQIKISTGKNSPHSKSLTLNVAGNTNTIRMVNAANLNLGHLAGKPILLASSKGGTIQNIQGQNVILQTQSNTSAPSLVLQNAVKTSGNSMVQQSASNNINIINQPNIVFSPQVKVQTPQQVMFTSAKSGQVSGAPSISQGHIMIGGHPVRLHTSNATNTQRLVLASQGQGGQIVAQQILLPAGFQGTAINIKALQGVKVIPIAQAAGQGKGIQSRQVLAHVVNPSAVKTSAQSSSLSTEKVSDMAISTEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCD5</accession>
    <name>A0ABM5KCD5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507849.1">
        <property type="nucleotide sequence ID" value="XM_050651892.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651892.1">
        <property type="protein sequence ID" value="XP_050507849.1"/>
        <property type="gene ID" value="LOC126885336"/>
    </dbReference>
    <dbReference type="GeneID" id="126885336"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="167" mass="19682" checksum="2816CF5AAB46A589" modified="2025-10-08" version="1">MVIESHCDENVTTHQFAKHFDSLLAEFNKRFEEFSELETFLMFFINPYSHRNEDLSEKISIYFSISNKEDLELEIINITNDIQLKSYCNEENFWNLVDINIYPLLRKCALKLNSLCASTYACESLFSNMKYLKSRYRSTLTDAHLDQCLRTGNSTYIPHYNELASNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDD8</accession>
    <name>A0ABM5KDD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear hormone receptor FTZ-F1 beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508194.1">
        <property type="nucleotide sequence ID" value="XM_050652237.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508195.1">
        <property type="nucleotide sequence ID" value="XM_050652238.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652237.1">
        <property type="protein sequence ID" value="XP_050508194.1"/>
        <property type="gene ID" value="LOC114335067"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652238.1">
        <property type="protein sequence ID" value="XP_050508195.1"/>
        <property type="gene ID" value="LOC114335067"/>
    </dbReference>
    <dbReference type="GeneID" id="114335067"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07167">
        <property type="entry name" value="NR_DBD_Lrh-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06930">
        <property type="entry name" value="NR_LBD_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF25">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="483"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="78510" checksum="699210201B68D11C" modified="2025-10-08" version="1">MATDMRSPNVSVTPINVEPYPPPGEPPQRTRSAPHPAALISNGTVDVLDSSDAEVARIDFQSVNMRSKIKREDIPRPMSWEGELSDGEREGMCIDEENSAPVPENLSLPPSKPPYINDSKESPVLRLKQPPMGNYSLHSTPSNSPLLSQRHPITGVPIISHKDLMMHKGLNVPPTPSPDSAVHSAYSVFSSPTQSPLTQRHVTFTPNLSRNNSDASHSSCCSYSSVSVSVSPTQQFSPTHSPIQGRHMPNFHSSPLHQHSYIYRSLQDENLQYSTEQDTLDETEDKSGIIHASLPAQPGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCLRGAQCPVTVATRKKCPACRFEKCLQCGMKLEAIREDRTRGGRSTYQCSYSLPPSLANHSDLRASSTDLRQMGEGHQSLTVKLEPPDPQVASAKRSMFPGSKGVPPLLQEIMEVEHLWHYNESELNKLYTDGHLGKEGSSGAVNNLSTHPLLAGTALAASADTSPDFVANLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSMTTPGEIRISLGKSISLAQSREMGMQACIERMLNFTEQLRRLRVDQYEYIAMKVIVLLTSDTSELREAEKVRLSQEKALKALQDYTLSHYPESPAKFGELLLRIPELQRTCQVGKELLTIKSKDGDGPSFNLLMELLRGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG33</accession>
    <name>A0ABM5KG33_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509159.1">
        <property type="nucleotide sequence ID" value="XM_050653202.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653202.1">
        <property type="protein sequence ID" value="XP_050509159.1"/>
        <property type="gene ID" value="LOC126886330"/>
    </dbReference>
    <dbReference type="GeneID" id="126886330"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="31"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="954"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1098" mass="127806" checksum="88155C86921FCC46" modified="2025-10-08" version="1">MECNENIKDSRNQEILTGIKDEGDSLQKYNNIEVKSELDESSYGQESVLDGYCSDSSDSEDIKIEDHVLEDVSNEIKLEIKKELEECSVGDPQDITGKVTKPFGAPKEHLKTYTGERTYKCEICNKLFTTKGNLKIHMRIHTGERLYKCEICSKKFTQKRTLNMHMKVHTGEKPFECEICSKLFTTKDNLKQHKIVHTGEKLYKCEICSKQFTQKSSLNTHKRVHTGEKPYKCEICSKQLSHTSALMYHMRVHTGEKHYECEICSKKFTDINHLNTHKRVHTGEKHYECEICSKKFNDISNLNTHKRVHTGEKPYECEICSKQFAYRDHLKGHMRIHTGEKPYKCEICFKQFTHKASLSIHNMAVHTGETPYKCEICSKKFTQKGNLNTHKRVHTGEKPYKCEICFKQFTHKVSLSTHNMVVHTGEQPYKCEICSKKFTGKSSLNTHKRVHTGERPYKCEICSKQFSRLSSLNYHMRVHTGERPYKCEICSKQFSRLSSLNYHMRVHTGEKPYKCEICSKQFSRLSSLNYHKRADTGERSYKCEICSKLFTEKSTLSNHMRVHTAQVAHSSKRPDSEIDDSMTDEDSVDEDEAVDLENLSKHQPLADAEVRIADGIIIGEDILIQQSESTCSKSVRLKSDPQDITAKVTKPFSAPKVHLKTYNGERPYKCEICNKLFTTKGNLKIHMRIHTGERLYKCEICSKKFTQKRTLNMHMKVHTGEKPFECEICSKLFTTKDNLKQHKIVHTGEKLYKCEICSKKFTQKRTLNMHMKVHTGEIRYECEICSKLFTTKGNLNTHQIVHTSEKPYKCEICSKQFNQISNLNIHKRVHTGEKPYKCEICSKQFTIISYLNTHKRIHSGAKPYKCEICSKQFTQISNLNSHKRVHTREKPFECEICTKQFAKRGVLKGHMRIHTGETPYKCEICSKQFTHKLSLSTHNMVVHTGEYEIDNKRYECEICSKHITTKNSLNNHMRIHTGEKRYECEICNKQFIEKGDLKRHIMRIHSGEKPYKCEICGKLFTEKGDLKRHMRIHTGEKPYECEICSKLFTTKGNLNTHKIVHTGEKPYKCEICSKKFTQKRTLNMHMIVHTGEKPYECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGI2</accession>
    <name>A0ABM5KGI2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509295.1">
        <property type="nucleotide sequence ID" value="XM_050653338.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653338.1">
        <property type="protein sequence ID" value="XP_050509295.1"/>
        <property type="gene ID" value="LOC126886404"/>
    </dbReference>
    <dbReference type="GeneID" id="126886404"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="560" mass="65118" checksum="F1C45B76E9002751" modified="2025-10-08" version="1">MEIKQEVGEKTLKVEIDDQCFGPLDVFKIEIKEEPKRETAYQAFDYLDSNEFTVSTEVEGSEDKFIPFKENQTTNEESCSQEENQPNIMEMLLSSHKEKYTGQHGQRPYKCEICFKQLTTKSHLKRHLSRHTSDRRRQCEICLKQFSQTGHLKRHLRTHTGERPHQCEICLKQFYRKCILKRHLRVHTGEKPYKCEICLKQFSEAGNLKKHLRTHTGEKPHQCGICFKQFSEAGSLKIHLRVHTGEKLAVHKCETCSKLFSKASILKVHSRVHTGERPYKCEICLKQFIRRSHLNLHLKVHTGENVYKCEICFKQFTQACNLKIHLRVHTGEKPHHCEVCFKQFSQAGSLKTHLRTHSGETPHQCEICFKQFSQAGSLKTHLRVHSGENPYKCEICLKQFSEAGNLKKHLRTHTGEKPHQCEICFKQFSEAASLKIHLRVHTGEKLAVHKCETCSKLFSKASILKVHSRVHTGERPYKCEICLKQFIRRSHLNLHLKVHTGENVYKCEICFRPFTEACNLKIHLRVHTGAKPHHCEVCFKQFSAAASLKIHLRTHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGT4</accession>
    <name>A0ABM5KGT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
            <ecNumber evidence="13">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="13">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="13">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="13"/>
    <dbReference type="RefSeq" id="XP_050509395.1">
        <property type="nucleotide sequence ID" value="XM_050653438.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653438.1">
        <property type="protein sequence ID" value="XP_050509395.1"/>
        <property type="gene ID" value="LOC126886480"/>
    </dbReference>
    <dbReference type="GeneID" id="126886480"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5044899042" description="Phosphatidylserine decarboxylase beta chain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044899043" description="Phosphatidylserine decarboxylase alpha chain" evidence="13">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="13">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="13">
        <location>
            <begin position="76"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="13">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="406" mass="46385" checksum="E816E0FDF8A4575A" modified="2025-10-08" version="1">MSILIQKSRMFYRLIPLRSFMLVPQKTTTLSSRFFLTSAVNRNVSTKQKSSRGSEWQMIITRFLPVGICLVAVMQWRALRKRQKEGIASKWEINCYCLLPLRTVSRCWGYIADVTLPEVLRPPVYKMYSNAFGVNIAEAENEDLTSYPSLADFFARSLKSGVRQVDESSCLVSPCDGTVLHFGTVDTEQVEQVKGVTYSLKDFFGENTGKVQKYNGDFKTSLLHKPHEGNVLYQCVIYLAPGDYHRFHSPSEWKPTHRRHFSGQLLSVNPSIASWLPGLFTLNERAVYLGQWKYGFFSYTAVGATNVGTVKVYFDKTLQTNKPFKKQTKEEVCLGNSIELKRGDIMGEFRMGSTIVLIFEAPKHFTFSIMPGEKVRMGQRMGCVFEHQQKFVDRLTNEKVDIRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJN8</accession>
    <name>A0ABM5KJN8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510422.1">
        <property type="nucleotide sequence ID" value="XM_050654465.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654465.1">
        <property type="protein sequence ID" value="XP_050510422.1"/>
        <property type="gene ID" value="LOC126887116"/>
    </dbReference>
    <dbReference type="GeneID" id="126887116"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="199"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="672" mass="77250" checksum="7CA7939FC1C423E5" modified="2025-10-08" version="1">MEVKKEIKEELKEYDQRYVDSLLSSSTIPEDYKNESEEKYSVDINEEFGKHDERYGKSQLSTSLNLENIKNEPEGEYSGSKRKKRKKTFDLTNPQDIEEVNRLFAASDEDDDDFRGESCGEESEIYSDGVEERDEGSDTEQEGADEDEDSFEKSNIFYLGKDKVTKWNRTAQKRNVPRVSDNNITQLLGVIGEAKLAKTPVECWNCLFTNDILNDIVMYTNQYIDAIKGRFSRERDVNNTDLLEIRAFVGLLYLAGAYKANRISLEELWGKNDDGIEKFSLVMSIKRFKFLMRCLSFDDLETRSSRKENDRLAPIRDIFTKFVQNCQASYYVGESVTIDEMLVAFRGSCPFRQYIPSKLSKYGIKVYALVDAKTFYSYNLEIYTGKQNEGPFCVSNKTPDVVKRLAEPLFGSGKNITANTRFTEVSLANELKERKLSYVGTIKKNRKQLPKEFIVTKNRAQYSSIFGFSDDGVTLVSYIPRKGKNILLLSTLHNDHSIDRNTGEKFKPEIITYYNATKLGVDTVDKMIASYSVTRNISRWPMVIFFAMLNIGGINSHVIHIGNRSEFLKRRVFLKQLSHELVLGQLARRSTNTIGLSLHFQRKLKRFCSPDVAPNEQNNEESQIPSKRRRCETCISETGLRRLSKYECKKCHNAICLSHAVFMCSPCYNGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKF5</accession>
    <name>A0ABM5KKF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_050510682.1">
        <property type="nucleotide sequence ID" value="XM_050654725.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510683.1">
        <property type="nucleotide sequence ID" value="XM_050654726.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510684.1">
        <property type="nucleotide sequence ID" value="XM_050654727.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654725.1">
        <property type="protein sequence ID" value="XP_050510682.1"/>
        <property type="gene ID" value="LOC126887302"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654726.1">
        <property type="protein sequence ID" value="XP_050510683.1"/>
        <property type="gene ID" value="LOC126887302"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654727.1">
        <property type="protein sequence ID" value="XP_050510684.1"/>
        <property type="gene ID" value="LOC126887302"/>
    </dbReference>
    <dbReference type="GeneID" id="126887302"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF45">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="618" mass="69883" checksum="AB2DC6661D11CC20" modified="2025-10-08" version="1">MTDDLITETPSRKRRTFSAAMIRLLGTRLFTRLLLLVCSLSLLSLLFLSRCGFHGLDATPNAANSPNSALDPQDPADVQPDAQAAFLDGSTMIGGAPQDISSIQSQQENSNSLQQLLQQREEETRQEIERLTAEIRALKLQLLQYTNSGTNSLQAPRQASSSISFNSSTNPTITNAECSNYIRKQIMQAEIFRGTPLNNEYELIPYNHFTYSRVYPIDLGLGKRVVEKPIGYKRKDLLEALMKGLEILNKNVTEKMSRYTLDDFLEGLYRVEPTTGTQYELYFRTKVSGFTKVIIMRPFAPLQTINTVSLTGPKEKELIHIILPLSGRTATFQSFMDKFVKIGLKNDRRVHLTVVYFGEEGLSEARSIMSRVLMTKNSGGNPNNLRLLALNETFSRGKGLRVGAERTWDLEKSKDSSKDVLLFMCDVDVVFSARFLDRCRWNTQSGKKVYYPVVFSLYNPHVVYTLQGRDVPPENDQLVISRDTGFWRDFGYGMTCQYRSDFLKVRGFDEDIVGWGGEDVMLYRKYVRSNMKVIRATDPGIFHIWHPKVCSGSPGGQKLSADQYRACIRSRALNEASHAQLGFLAFRDDIAANSSPAKYNPHQIKTLKTAPKKLRTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKG0</accession>
    <name>A0ABM5KKG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050510686.1">
        <property type="nucleotide sequence ID" value="XM_050654729.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654729.1">
        <property type="protein sequence ID" value="XP_050510686.1"/>
        <property type="gene ID" value="LOC126878425"/>
    </dbReference>
    <dbReference type="GeneID" id="126878425"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="159" mass="18164" checksum="38614F954FD6093B" modified="2025-10-08" version="1">MPEHTPAPTPSRAVYGFVMYLSFRIFFIIYVIWAVLPEKYFKAVGIMFLPQRHWAITVPVYLLTVLTTVAFVIYPSLGLCMTPAVDDMRTIKDKVGSKKRHTEVHLDGGSSGTSCVCKDRDKCSRQLYNSIQHTFVNNTIPVSRDLEMWDVSDHLYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPF1</accession>
    <name>A0ABM5KPF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512061.1">
        <property type="nucleotide sequence ID" value="XM_050656104.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656104.1">
        <property type="protein sequence ID" value="XP_050512061.1"/>
        <property type="gene ID" value="LOC126888084"/>
    </dbReference>
    <dbReference type="GeneID" id="126888084"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="885"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125833" checksum="68A2F0E741D05F54" modified="2025-10-08" version="1">MDKSRKLKFQRHTALNDIQSIFDLGNRAVSDLSLRSLFKIRVSEIDLIKDEFLKQHTSIIINVLSVPDSDTGDEEKVRELFLDLFYKIKVFDAEFFGSPSESPGPASCASGGAHPSHIRLPRIDLPHFQGNFINFASFIDLYNSIVHNNAALGNIEKFKYLKGCLDGTPLSLISNLPITNDNYQVAYDLIVKRYTNVRRCATAHWDAIMCVQKISAVNSKNLAKLVDTFLENLAALKTLGLPTEHWDFIMFNLLLSKLDVDSIKLFELENKSNEIPSFKKLVVFIETQYIAYDNLDSSIGEGKKSSRAPNNTEPKANSKHQTGDSRHNRSSSSFVTNSSSCLNQANHSVKSCPKSFKCSKCSSHLHNSLLHFERNRSNSQSSSENHSPGTSGIESSPEVSHCAASFVGNKNETKKEILLGTVLVHAIDSKGCKQPLRCLIDSGSMSSFISRKAANRLGWPKTPCSFEVNGLNSMQTKLNQGQISFSIQPRHLESPVFHLEAIITDRVCSDLPSTQIDISAWNYIKNLKLADPKFNCSQSVDLLIGCSIFSKLLLEGKIEGKPGQPDALNTVFGYILLGPTSTPNLSSTFSSSSSLVCLSNVEDSLDSSVRKFWELENIPEEPVSEPEDVLCETIYRETHSRDVSGKYVVSLPFRESPPCLKDSYDVALNRFISLERRLFRQPGLQKDYSSHMQEYIDLGHMQLVPEGEKTKGKYYIPHHCVVKSESVSTKIRVVYNASQKSPRLEVPPSLREKSPSEEVKKSLVFVSTREEHFLSCLLENQSSFTSIQRILAFMLRFAHNSRLKRSRRVGPLSSVELESSLIILVRFTQEQYFEDQLQSNSFPKPFRKLGVFLDDDTQCLRVGGRLSQSSLSYEAKHPFLLPKKSRLTTLLVRHYHEKYLHAGFKSTQFLMSQRFWILSSKQSVNSVLSKCIRCWKQSPRALQPPMASNGPGDSYSQPVSQTNIQGVADTNMQVQQFINSQPITQAALNNNNSCLSHQHFDASQANSTQQVPINQQNYIHQVPMIQKSQHIPSTSQKYYHRLSSTSDDEQLEQHAANENEWQQNAMSSPETTIEGSRVNGSDVTRGLLASRRFPRNLEPETDHSIVVSRPDRSFLPGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPK8</accession>
    <name>A0ABM5KPK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF229 domain containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512125.1">
        <property type="nucleotide sequence ID" value="XM_050656168.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656168.1">
        <property type="protein sequence ID" value="XP_050512125.1"/>
        <property type="gene ID" value="LOC126888177"/>
    </dbReference>
    <dbReference type="GeneID" id="126888177"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="75312" checksum="2E01C26C118D0E62" modified="2025-10-08" version="1">MFVYGKYTEKTIGKKVDFKCFIIFLMGITILVCVYQQDSIFSRTEIIENISGEELKLTAEATSNGGVFTINTPGCTIPYLHPYDKSILDYVEQPGKYVCNNGTPALFETDMESIKIIEKSLSFYNITNINDLKCCYKAFWREDPHTMADKKISYSNSCETFVNKTDIKEEFIKVTCNYKNRLIYTDVFASVPVKNFTDKVKEDQDKNGSPLNILVLGLDAISRLNFQRQMPKTLNYLRQLGAVEMLGYNKVDDNTFPNVIPALTGKFVKEIQKPKGCWPNKNHHFDDCPFIWKSYKQKGYVTAFDEDSSWMGIFNLLKYGFQKQPTDYSFNYFDREAIKLLGNTNVGTVAICQGARWIYKVHIDYLTQFVRTMEDNSLKYFGFFWENSISHDDLNLPRLADDDYYSMLKSFEEHDYLNNTILFVMSDHGIRTGKIRTTFQGMMEERLPLLFVYLPDWYKQRYHHEYSNLLQNSLRLTTPFDLHETLVHLLDIENSDTEDNSTDKARGISLLKKISEYRSCEDIGIVSHWCTCQKSVEVDIKNQTIKEVADFSVKYINKLLSAYSQCSKLQLNSIASARVMEHSKEILGNLQVSDYMLSFVTIPGNASFEATVRYSSQSKNYAIVGSISRLNLYGKQSACISDYELKLYCYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRE1</accession>
    <name>A0ABM5KRE1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512755.1">
        <property type="nucleotide sequence ID" value="XM_050656798.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656798.1">
        <property type="protein sequence ID" value="XP_050512755.1"/>
        <property type="gene ID" value="LOC126888464"/>
    </dbReference>
    <dbReference type="GeneID" id="126888464"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="311" mass="35782" checksum="074D123C8C0DA3B1" modified="2025-10-08" version="1">MSSTQVRKNRKNNQFCNILRFLFCCTSVRRPDHVNFKQHPLEVNNSSQVELERRITHQCQIHNAVFRCSAMLELIDPKEIKSVYFDHDMQTTIDKLDSLIKTLSEVLELYKQEADVFKQKADHISISEKSSSKEAEIEYPSDKGDCHKVLNNSSKNYLPIVSRRSTCGPKTRSINPTTRIIYSKQVCKKANINISSMQVGHIQLTSHFGLFSNKILDNLTIINTDVENLKRLLSSLKGILVFKENVLISFGCGGLKNCYITNELSFGNPETFADAKVSASHFCRFHKLSQTYNEKHKKPRSLKIYNKRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSI1</accession>
    <name>A0ABM5KSI1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513141.1">
        <property type="nucleotide sequence ID" value="XM_050657184.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657184.1">
        <property type="protein sequence ID" value="XP_050513141.1"/>
        <property type="gene ID" value="LOC126888803"/>
    </dbReference>
    <dbReference type="GeneID" id="126888803"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045709375" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="125"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="347" mass="39223" checksum="5EBC6555C127FACA" modified="2025-10-08" version="1">MIFLSLFALVSVVLAEYQILGSAEEHNPVNVKLTKLLDVKVESKADSWKNDFSRFFQPQSDEISLGRKDEHNVQIPLKLSLGVEQSGVNEDYSQNFFSIFKKCKSLVGRSKTPICHLNPLPEYSDKYNAYPGSCREILDNVSNKTGIYTIKPRTSKKPFSVLCDMETKGGGWTYIQKRFDGSQEFYLGYKDYKFGFGDLNGEFWIGLENIHHMTGSEINELLIELTDRDKKTAYAQFKTFGIGPEKDGYILNVLTGYSGDAGDALSPHLNSKFSTFDVDQDEHPGNCALMHEGAWWYKACHTSNLNGKHINVNLSATYNYHGVNWNGFRGHLYILAGSKMMIRAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSS1</accession>
    <name>A0ABM5KSS1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513239.1">
        <property type="nucleotide sequence ID" value="XM_050657282.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513298.1">
        <property type="nucleotide sequence ID" value="XM_050657341.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657282.1">
        <property type="protein sequence ID" value="XP_050513239.1"/>
        <property type="gene ID" value="LOC126888852"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657341.1">
        <property type="protein sequence ID" value="XP_050513298.1"/>
        <property type="gene ID" value="LOC126889059"/>
    </dbReference>
    <dbReference type="GeneID" id="126888852"/>
    <dbReference type="GeneID" id="126889059"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14094" checksum="85698C77F8A308C0" modified="2025-10-08" version="1">MDAIQLLQPHTAMDIPGTSQPPPAMDIPSKSRAPPVMDVPSTSTGLTPIIIQDEKDSLQQGGPAAAKTTKGSKRKCPSCEEMQDNKNLVLDKKLEILEIVRRKELVELKLKEIELKSKDPNWNPNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT30</accession>
    <name>A0ABM5KT30_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Glutathione synthetase</fullName>
            <shortName evidence="12">GSH-S</shortName>
            <ecNumber evidence="3 12">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_050513348.1">
        <property type="nucleotide sequence ID" value="XM_050657391.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657391.1">
        <property type="protein sequence ID" value="XP_050513348.1"/>
        <property type="gene ID" value="LOC126889276"/>
    </dbReference>
    <dbReference type="GeneID" id="126889276"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="273"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="548" mass="62883" checksum="20646E1692A70967" modified="2025-10-08" version="1">MVKTTVVLTRLNKIDEYIIIISFNCAVKEDGSRVSHCICFGSQEEEKRRQRTTWIKNWLNRRSSHGYGRYGKLLRGLRSEPGKDWAITNGTCMRSKTNFSEDSVNFAPFVLLPSTMPRRDFEQVVSLQTAFQELIHYVANDREFLTKCLTKIIEVDSFTAKLFEIYETVQEEGETQPISVGVLRCDYMMETEKLNGEKCHENGFPPFSWKLVEINNIAAGFGWLGPASGLLHRYILQEMNLYDKSSNLPENNCLSEFCKSFLEAWKIYGNCQAVILMVVEDVIYNICDQRHHEFKFRELNPQVKFIRRTLTEIYKTGKLNEKKELVVGNDVVSVVYFRCGYNPLQYPTENEWTARLLIERSKAIKCPNIQYHLAGTKKVQQELAKPGVIDRFIKDRRKVELIRDVFVGIYGLEFDDDGEKAVRMALKTPERYVLKPQREGGGNNVYGKDVKEYLERMANSKERESWIMMERIIPPIIRGYMVKPGGSNPPPISEMILELGIFGIIIGTPKTIITNIQTGHMVRSKIATANEGGVMIGLGALDSPYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV17</accession>
    <name>A0ABM5KV17_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514030.1">
        <property type="nucleotide sequence ID" value="XM_050658073.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658073.1">
        <property type="protein sequence ID" value="XP_050514030.1"/>
        <property type="gene ID" value="LOC126889601"/>
    </dbReference>
    <dbReference type="GeneID" id="126889601"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="936"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1153" mass="134646" checksum="B7A4541E40E017ED" modified="2025-10-08" version="1">MDMNTNTGSCTESLSNECCQFLNILNDDTFNPDNCLVWAQQNDPLVVDDDVDQQNMKYEKSKPPTGGVPYEIKLITLFAVTGVKYYKNCNWRLSTQDNCAGKFDDLVCQSNSGAILVQAKTKSTSCIPENEVISDSPKKTDYNLIAYILSYKNIKIKNIKYLLLCTNTHIKSPLFEISKQEDKQITDIFKRSKLFGVKLDTQTVRKIYRTIRKFKKNIKPDHKKELWKRTMVSKRDIKAFILKFRYIKISEAELGANIEEEINSFNQKVNYIYLLHQIETWYRMERNQEDYLTNLYTHSIFYGEQSRHLTEMYLDPSINFETMHEMYENKIVFVKPGIHYHWSLRRIVQSLRHFDKKPDNLFYNQILFIQENEISYINLFKLKKFKYLIICLPQSTNDQVKNACQILETIMGGNSKKLAFFVANETSYSNNNVLTSIEDKISLSWFNSDSRDVLLNREIVFQFPKKTLKLRELLNYAQDLEKHIDEQILTRLRDLNTFHIGRYVKSLENIKYCHISRSLKSATGLPVSNYDFDAFDKRVFVLVGPPGSGKSTYLIKVAHLKKERSPQTWIIHLDIASVVKFLEANEGEPLMNLFYQLEGTESNFEQELMNSLEKYVLIDGFIELNTTYLIYFKKMITLLLKVNSISKIFIALRDNHISMQALKAVKEVEILIINPFSEDDQQTYFNMAIQSIKDKSSFHKFVETFTKLNHLMSNPLYMSLMFEIFVESEKQTSIILTRENVYEIYNYFLKIKKRVFALEYSEENSVLCSILDDTFERYLNDMRLIAVKNIFANTDCEKFFELISIHDFVLRIGIIEKSYDEYIFRHKTFEEYLSAEYIWKLVCTKSKKILSELLDIIFFNFEYAGTCSFFDDILQIASKDNLTKISEVYNEIFSEPERIERTNITYLAQQGNINTLKLFLTKSKDCSKILSKTYSNGRTVLHYSATYPKLIEFLAEKGADINALDDKGYGICHYAMSSYLSEMYNKSMTTKDVHALVRYLMIERDDFLVDIVDEFGNTLLHYFCMDNQLLEIVQFLCSENTSLCTAQNLFGNTPLHFAAHNDAHEIIHYFVEHMNIDILRVKNLKGDSLIHSASSGNAVNVLDYINESHEVIFKDLIDLENDNKHTALDHAFLNCAYEAIQYLEGNYAKHGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVC6</accession>
    <name>A0ABM5KVC6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514138.1">
        <property type="nucleotide sequence ID" value="XM_050658181.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658181.1">
        <property type="protein sequence ID" value="XP_050514138.1"/>
        <property type="gene ID" value="LOC114341469"/>
    </dbReference>
    <dbReference type="GeneID" id="114341469"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11416">
        <property type="entry name" value="bHLH_TS_ceHLH13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF97">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23320" checksum="0CCA05CA7AC28DA3" modified="2025-10-08" version="1">MTNRVHQLPDSSSSPPSLQFGYSAGDMSEDEVSDLPSCAFASRPSSNSSLQHHYLSSLHHGGDGQCAGTLSSSGDYYGSSPYRVQRHAANIRERKRMLRSAIGPTGSINSAFDELRMHVPTFPYEKRLSKIDTLRLAIAYIALLREVLTADCDPLTYVERCLRGEIKADRANWNTSDLTARLSWINWENLGVTPGRRSALTSLALTSENNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVD3</accession>
    <name>A0ABM5KVD3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514152.1">
        <property type="nucleotide sequence ID" value="XM_050658195.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658195.1">
        <property type="protein sequence ID" value="XP_050514152.1"/>
        <property type="gene ID" value="LOC126889671"/>
    </dbReference>
    <dbReference type="GeneID" id="126889671"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="646" mass="74134" checksum="41081230B011F894" modified="2025-10-08" version="1">MAPQKNGRVYDSEVKCCKKCYKVAQSGLLCANCGTLSHSGCLKQLKSIKYIDDETVICCEESVRLSDPPNKTLDSEADDEDPRQTEISDGPKTMARRLLCKQVFYEASNTYSNKMKDEETTVNPPSNFQNNLIQQGTVSMFHVNLQCISNKVDMINAFLADKKFYDVICFSEHWQTEENLKLINISGFSLANFFCRVEKKQGGVAIYVKENLMYSSLNLNEYNVEQTSEFCAIYIPSMRTNVLTVYRSGNGDCDLFLVNFENVIAFLLNKADKLIIFGDFNINFKIKSESSYDIQNLLMSFGLEITINDYTRITSQSSSCIDNIMTNFSENIYRVGVFEPCFSDHRAQFISIDSDLKVVDTNQSLQRSITSSGLQKLKYALASTKMDFFYDTNNDPDVLMFFLTETYNNLILKFFPLKKVRQTAKITPVQWFNDELRSYRSNLSLIKHIADVTKDPDIFKLYKQQKYEYNRQLQNAKKSAYSGFITNSNNKPRDCWKILNFERGNTRSSSVQPDLSPDEINQFFITIAENIITSLPTINNDILFSYRNYPSPSKSFCFRPVVEDEISQIIKSLNNSNCKDVHEINSKILKETYQIVLTPFTHLINLILSTGVFPEALKYSKVGLRQLIAGFFPSEEKIHRNSIELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVF2</accession>
    <name>A0ABM5KVF2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514168.1">
        <property type="nucleotide sequence ID" value="XM_050658211.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658211.1">
        <property type="protein sequence ID" value="XP_050514168.1"/>
        <property type="gene ID" value="LOC126889691"/>
    </dbReference>
    <dbReference type="GeneID" id="126889691"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="13">
        <location>
            <begin position="463"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="610" mass="69561" checksum="645B1A13F390A957" modified="2025-10-08" version="1">MVKAGLSPCDPSSFSRPDQVIVTELFLNLDVNFESKTLHGHAILSINKIDETATELVLDTFKLNITSIFDADKNCTEKLEYTLSDHLEDFGSKLTIQLPQKEVKKIHIEYETAPDASGLQWLQPQTTAGKIHPFLFSQFQPTHARSVIPCQDTPAVKHPYRATISAPKELEVLMSAINEGSKVIGDKKQYSFYQQIPVPSYLIALAVGALESRRLGPRSHVWAEKELIEESAYEFAETEHQLKTAEDICGPYVWGIYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDRSLANVIAHEISHSWTGNLVTNKTFEHFWLNEGFTMLVERKIISRLVSPQMQDFDAYTGISDLKEAIEVLGADSPLTNLIVDLKGVHPDEAFSTVPYEKGQTFLRYLEKTVGGPDKFEPFLRSYFDTFKYKSIDTTDFKNFFENYFESEPEIKNIDWDKWLHTPGMPLTIPDYDTSLAEACDQLLEKFYNWTGEGSLPISAEDKQQLIPEQLIYFLQKLSEAESQPIPKLVALNELFGFDGVKNSEIKFRWLKTGIKAKWEVQIQNALDWVNVVGRMKFVKPLYRELFQWEVSRNRAIENFKSNRHNMMHVCATTLAKELKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXP7</accession>
    <name>A0ABM5KXP7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514968.1">
        <property type="nucleotide sequence ID" value="XM_050659011.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659011.1">
        <property type="protein sequence ID" value="XP_050514968.1"/>
        <property type="gene ID" value="LOC126890160"/>
    </dbReference>
    <dbReference type="GeneID" id="126890160"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="750"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="959" mass="109800" checksum="761ECC3CE2FD0C2E" modified="2025-10-08" version="1">MKRTLQQSLLGFFPKKGKTNDELNPQNDKILTTPSMDISTDGDAPTPSTSDRNRETSHEHVVTELDARFKPHEEAISGIQLLLPDRTQNTERAKKCIAGIGEIFLREVEIKHLVNQAVTENNDDSQPCNNSMTNYAAISTEENNIETQLETTATEVLIDIDRAHLACITASVDHIESSKENIVNPQVEKLEATGIIFVDMGTLPAEESSSNCQTDISKGNIVYSQLEEKITEVIDIASLDVYILPEGELVTNNLVDQTDVAEDELVTNNLVDRTDVAEDELVTNNLVDHTDVAEDELVTNNLLDQTDVAEDELVTNNLVDQTDVAEDELVTNNLVDQTDVAEDELVTNNLLDQTDVAEDELVTNNLVDRTDVAEDELVTNNLVDRTDVAEDELVTNNLVDQTDVAEPRDTSTNIKKRKRGVGPWVRVVRKERTDKKNRGDSYVTVTGKHVAQRMVKETLKPCRSKCADFFTFDVRQTIFQEYWSLGTHDRRTQYISGLVTCKNTMTTRKRNEDSAKSRQVTYTYHLEYKGERRVVCKTCFMDILDEKEKFVRIALTNKGNHRSGITDADKRGRKSPGNKKTEHMRELIINHIDSFPQYESHYTRRDNINKYLPNHLSLKKMYELYREAVTEPVSRTLYEEQFHKMKLKFKERKTDTCHKCDVYKMKLEVCDNEEQKQMIVEETNSHHEAADLAYNTKKEDKARAQIDPSIKCYTFDLQQCLPTPDLETSVAFYKRLYWTYNLTIHDCATGKASCYLWHETLAKRGANEIASCLYKEIMDLPDSVKKIVLYSDTCGGQNKNSHVAAMFTYLLQQKNTIEEIHHKFLIPGHTRMECDADHSLIEKKKKKSATLIAHPHDWSTLIRCTSNKFKIVEMEQNEFLDFAELLKGPLVQKHKNNSGERFLWRECQWLIYGRIFGQFDYSTSLKSDTPFKRMSLRRRGRGHTINVTSAYTGPLPITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXW9</accession>
    <name>A0ABM5KXW9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515022.1">
        <property type="nucleotide sequence ID" value="XM_050659065.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659065.1">
        <property type="protein sequence ID" value="XP_050515022.1"/>
        <property type="gene ID" value="LOC126890211"/>
    </dbReference>
    <dbReference type="GeneID" id="126890211"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="106" mass="12062" checksum="7F4743A10D5F0654" modified="2025-10-08" version="1">MKKCEEGRRWKIIIYQLNRLTKGCVGMLSLTVSLVCALIVNQFIHMTESITTNIVCSKWYTADISVKKDVLFILLSTQRPFTLNALPLGTLNLELLLLVRMNMLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY16</accession>
    <name>A0ABM5KY16_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515084.1">
        <property type="nucleotide sequence ID" value="XM_050659127.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659127.1">
        <property type="protein sequence ID" value="XP_050515084.1"/>
        <property type="gene ID" value="LOC126890270"/>
    </dbReference>
    <dbReference type="GeneID" id="126890270"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="34294" checksum="2EA3BABC075BE1AA" modified="2025-10-08" version="1">MECFKPPEAFNVQEPHGWLKWKQRFEIFMLASEKNTAAEKIKIALLVNIIGESCLDVYNTFPNCKTSKLEDVLSCFDDHFLPKTNTTMETFKFNSIHQKEGQTIDSFLTELKKQASNCAFICENDQCKASYADRMIRDKLVLGIHDRQVQRHLLREPAMSLEKMQEYCRSIEVTMQHVELLNKTEEEPQEVLALRYGRPEGRTNKKNEKCSRCAYAHEPRKCPAYNQTCRICQRRGHFAEMCFFKDQNNSVQRRVSEVTEAQETSIDTDLEYIVHALSLTLPITKEKKLIVMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYT3</accession>
    <name>A0ABM5KYT3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515342.1">
        <property type="nucleotide sequence ID" value="XM_050659385.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659385.1">
        <property type="protein sequence ID" value="XP_050515342.1"/>
        <property type="gene ID" value="LOC126890441"/>
    </dbReference>
    <dbReference type="GeneID" id="126890441"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="131" mass="15281" checksum="869070A0432A12BD" modified="2025-10-08" version="1">MKWFQGDDDEEEDLMCSPAFLARRASESWIETPPVENIAPQTSLQRKKSLPDFQDLPRATGAMSREEVSYLGSARREEIRRQADEYERLRANPLLYLVSPQVKDWFSRQQLVLVVLFINISLAIMFFKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZV0</accession>
    <name>A0ABM5KZV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515715.1">
        <property type="nucleotide sequence ID" value="XM_050659758.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659758.1">
        <property type="protein sequence ID" value="XP_050515715.1"/>
        <property type="gene ID" value="LOC126890649"/>
    </dbReference>
    <dbReference type="GeneID" id="126890649"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="118"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="512" mass="59890" checksum="9D5535345EDC0D21" modified="2025-10-08" version="1">MADLNKAGPSGVKRRKTVKVRNEKNLSVEELMQFLYNSDSDEDYEDSDVDNFEIENVSEDSSGSDTEDDVLQNELNNTVANNPDVQITDNEWTETTSGMKQIPFTKRSGLLVDSPGDSAYDWFRLLFDDELLNMIVLQTNSYAVEVLSTSKGCDRSRISLWKELTISELLIFIGLTFHTGTIQLRSIQDYWKKNRLFSTCFSSYMSRDRYLLIMRCLHFAENVKENEPVPVDRLYKVRPLLDHFNNKMKTVYYPGKYLSLDESMILWKGKLVFKQYLPKKRHKYGVKLYMLTEADSTILDIHIYAGAGDATAGKSHAERVVLHLMRNFFDHGHSLHMDNYYNSYNLAKLLLDKNSFCTGTLRKDRKGCPKNVVDAKLKKGQTKSMYLNNVMVGKWRDKRDIIYISTEYKNEMVTVRNRRGDEKIKPLPIIQYNKYMGGVDLQDQMSSYYPPTRKTLRWYKKIGIHLFQLYLQNAHRLYNKYHGTEITKCHIISFDCQYLKSYYQKNVKEQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0B2</accession>
    <name>A0ABM5L0B2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 6k1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515878.1">
        <property type="nucleotide sequence ID" value="XM_050659921.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659921.1">
        <property type="protein sequence ID" value="XP_050515878.1"/>
        <property type="gene ID" value="LOC126890750"/>
    </dbReference>
    <dbReference type="GeneID" id="126890750"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="57776" checksum="3554D68C3ABB619E" modified="2025-10-08" version="1">MLFTSSWFMDILLALSFVCFLVYKYLTRHFDYWKKRNVQHPPPIPLFGNMYNVLAMKSVTPEYIQSIWNEIDAPYFGMFMFDEPVLVLKSPKLIKDVLIKHSSTFYNRRIAIPAHPDMARGLFFLKDEQWKTMRNTISPLFTSGMIKQLEPHFIETNRILSEFLIKNSGVFDTSKIARNLTSEFLIRSFFNVEAKSFEDQPSVIMEQIDKIFKYSLRNVLVQNSFFFKPGLISAFKLNFIPESVIMFFEGIFKNSMMARESYIGKPQNLVDIANKSLRDNPNGGYTSDVEVFVSNALLFLIAGQDTTSTTVKFSLYELAMNQKIQNKLRNEVRANVQKYGSLTFEGVQENKYLGMCIDETLRKYPALPFIDRSARTDFQFEGTDLIVEKNMSVLIPSFSLQRDENLFSNPELFDPERFSDDSINSDGLSFIPFGEGPKYCIGKRLGILIVSMVLSHIVLNFKLEKCTETPEKIEFEPRSFVLSSKVGLPIMITPIKDEMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1U1</accession>
    <name>A0ABM5L1U1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516406.1">
        <property type="nucleotide sequence ID" value="XM_050660449.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660449.1">
        <property type="protein sequence ID" value="XP_050516406.1"/>
        <property type="gene ID" value="LOC126891269"/>
    </dbReference>
    <dbReference type="GeneID" id="126891269"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41920" checksum="E387C179D6B339F8" modified="2025-10-08" version="1">MGVIKEVCAFFHKSAKRTEVLKLTITECCPEQKKKKLISLCETRWVERHDSVLLFKELLEAVSLSLLKIEEESSDSAPKAHALGSSITQFQFLVNTFVLSHMLSKTHNLSENLQKKNLDLTQAVKNVSNVLDLLSKERENADNNFKVLYSQIQERADKLKIKEEVPRICRLQTARNNVPYSTQEEYYRRAVYLPYLDDFCNSLKERFESHKETVASLQNILPEFCIKTDFCALEPAFNSYEEDLSHKEVVESEFMLWKERWSQEKYENLPKSAVSSLEKCDQDFFPNIYVLLKLLAVLPVSVATVERSFSSLRRLKTYLRNSTSENRLNGLALLSIHRDFAISNEEVLDKFASVPRNLDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2K3</accession>
    <name>A0ABM5L2K3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516671.1">
        <property type="nucleotide sequence ID" value="XM_050660714.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660714.1">
        <property type="protein sequence ID" value="XP_050516671.1"/>
        <property type="gene ID" value="LOC126891537"/>
    </dbReference>
    <dbReference type="GeneID" id="126891537"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="413" mass="48023" checksum="36BAF6C4E50DB7E6" modified="2025-10-08" version="1">MFWENERDSHNVLVSEALSRNKFEYILSHFHLTDNVTINTSDKFAKVRPLFDHLNAAFLKFGKCEEMHCVDEAMVPYYGRHGCKQFIHNKPIRYGYKLWVGASRLGYVNWMEPYQGATTNISEKYIDYGVGPSVVLEYADVLRTRWPNKRMHLFFDNFFSTLSLLELLSEKNFNATGTIRENRISNGPLTNSKEIKKEARGVFDFKKTENQNIIVVKWHDNSIVTLCSNAVGVNPLHRVKRFSRKERTNIQVSQPHLINLYNANMGGVDRCDQNLSLYRISLRSKKWYFPLVAHCIDVALQNAWQLHRQRGGDLDQLRFRRRVATTLLLQNKKKETHSKGHKSSTEGLDIRFDRMDHLVIPQNKQTRCAHCHEKTTTRCSKCDKGLHVKCFFGIPYKKCIVNVGTLKCPSSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L330</accession>
    <name>A0ABM5L330_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516849.1">
        <property type="nucleotide sequence ID" value="XM_050660892.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660892.1">
        <property type="protein sequence ID" value="XP_050516849.1"/>
        <property type="gene ID" value="LOC126891663"/>
    </dbReference>
    <dbReference type="GeneID" id="126891663"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="3091" mass="336986" checksum="9AD55F712F0CCC95" modified="2025-10-08" version="1">MNIWPLMVSSENCEKIDWLQPFNNESSYTCNSNGWFADQTDKECRQYFVCVTNGESYIKIYLKCPTGSYFDNTINDCSAEYLCPYQTIPTTNKPSTEQIKTTSTYNIEDTSTQTHRITTYETNLTTRESETLSTENTPTTSGNNIASSTEREITESTKNLSTSESDTTISTTPEISTTEQQQTTPIDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNVLSSGRVIQTKYTCPSNSNFNPVKQLCDVDYSCPCPSAPDTTTTSSPTVTTNNNITTEVSTEELIPTTAVTTEGSSNQNVTDSSTSNNESTENVKTTSDNDVSTNTEPELTTSSIVSTTDSSISESDTTISTTPEVTTTERQQTTPIDECSYNDNPDYFTCRVKGRFRNANDRTCKTYYLCNVLSSGRVIQTKYTCPSNSNFNPVKQLCDVDYSCPCPSAPDITTISSPTITTNNNIPTEASTEEITFTTAVTTDRNNNQNVTDSSTSNTETTESVTNISDNVISSNTEPELTTSSIISTTDSSTSESDTTISTTPEVTTTEQQQTTLIDECSYNGNPDYFTCTVKGRFRNANDRTCKTYYLCNVLSSGRVIQTKYNCPSNSNFNPVKELCDIDYSCPCPSAPDTTTTPSPTVTDNNNITTEVSTEEKIPTTEVTTEGSSNQNFTDSSTSNNETTENVTTTSDKDVSTNTEPELTTSSIISTTDSSTSESDTTISTTPEVTTTERQQTTPIDECSYNGNPDYFTCTIEGRFRNANDRTCKTYYLCNVLSSGRVIQTKYTCLSNSNFNPVKQLCDVEYSCPCSLAPDTTTTSSSTVTTNNNITTKASTEEIKSTTPVTTERNTNQNVTDSSTSNNETTENVTTTSDSDVSTNTEPELTTSSIVSTTDSSSSVSDTTISTTPEVTTTEREQTTPIDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNVLSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSPSTVTTNNNITTEASTEEIKSTTAVTTERNTNQNVTDSSTSINETTENVTTTSDSDVSTNTEPELTTSSIVSTTDSSTSGSDTTISTTPEVTTTEREQTIPIDECSYNDNPDYFTCTIKGRFRNANDRTCRTYYLCNVLSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTEASTEEIKSTTAVTTERNTNQNVTDSSISNKETTENVTTTSDNDVSTNTEPELTTSSIVSTTDSSTSESGKTISTTPEVTTTEREQTTPTDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNILSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTKASTEEIKSTTPVTTERNTNQNVTDSSTSNNETTENVTTTSDSDVSTNTEPELTTSSILSTTDSSSSVSDTTISTTPEVTTTEREQTTPIDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNILSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTKASTEEIKSTTPVTTERNTNQNVTDSSTSNNETTANVTTTSDNDVSTTTEPELTTSSIVSTTNSSTSESDTTLSTTPEVTTTEQQQTTPIDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNVLSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTEASTEEIKSTTAVTTERNTNQNVTDSSISNNETTENVTTTSDNDVSTNTEPELTTSSIVSTTDSSTSESGKTISTTPEVTTTEREQTTPTDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNILSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSFSTVTTNNNITTKASTEEIKSTTPVTTERNTNQNVTDSSTSNNETTENVTTTSDSDVSTNTEPELTTSSILSTTDSSSSVSDTTISTTPEVTTTEREQTTPIDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNILSSGRVIQTKYTCPSNSKFNPAKQLCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTKASTEEIKSTTPVTTERNTNQNVTDSSTSNNETTANVTTTSDNDVSTTTEPELTTSSVVSTTNSSTSESDTTLSTTPEVTTTEQEQTTPIDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNVLSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTEASTEEIKSTTAVTTERNTNQNVTDSSISNNETTENVTTTSDNDVSTNTEPELTTSSIVSTTDSPTSESGKTISTTPEVTTTEREQTTPTDECSYNDNPDYFTCTVKGRFRNANDRTCRTYYLCNILSSGRVIQTKYTCPSSSNFNPAKQFCDVDYSCPCPSAPDTTTTSSSTVTTNNNITTKASTEEIKSTTPVTTERNTNQNVTDSSTSNNETTENVTTTSDSDVSTNTEPELTTSSIVSTTDSSSSVSDTTISTTPEVTTTEQQQTASIDECSYNDNPDYFTCTVKGRFRNANDKTCRTYYLCNVLSSGRVIQTKYTCPSNSNFNPAKQLCDVDYSCPCPSAPDSATTSFPTVTTNNNITTEISREDEIISTTVVTTERNNNQNVTESSISNTNSTENVPTTSDNDVSTNTKPELTTSSIISTTDSSTSESYTNVSTTATITTTEQQQTAHIDECSYNDNPHYFNCTVKGRFRNANDRTCGTYYLCNVLSSGKVIQTKYTCPSNSNFNPAKQLCDVDYRCPCPSAPDTTTTASSTVQEISTLLPTDKVTTEGIGLNSSTTETVQIDVCIYEEDPDYFTCTTSGNFPNLNDISCKTYFFCINIVDPILLIKSQYTCDKDTYFNPLTKTCEAEYVCPCIGRTSSSTNNIIQTTSTSSTESIDTSPKTDGSTSQDVSSSTASTTLDSNTTSSRSVPITGNSDSTTRDTESTTTSSNPGTSTPGQQETTPIDECSHNDDPNYFICTEKGRFRNANDRTCETYYLCNVLRSGRIIQTKYNCPSGSNFNPIKQLCDVDYKCPCVSLINTTTTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3C2</accession>
    <name>A0ABM5L3C2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 10">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 10"/>
    <dbReference type="RefSeq" id="XP_050516938.1">
        <property type="nucleotide sequence ID" value="XM_050660981.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516939.1">
        <property type="nucleotide sequence ID" value="XM_050660982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660981.1">
        <property type="protein sequence ID" value="XP_050516938.1"/>
        <property type="gene ID" value="LOC126891716"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660982.1">
        <property type="protein sequence ID" value="XP_050516939.1"/>
        <property type="gene ID" value="LOC126891716"/>
    </dbReference>
    <dbReference type="GeneID" id="126891716"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="727" mass="81131" checksum="5BEA41F87AC3D83E" modified="2025-10-08" version="1">MASRFKKIAVSGITGTIGAGIATYYLLRDDGKQPWPTAVSAKEASLKPKRILPTRADQIKSLQSEKFDVVIIGGGATGAGCALDAATRGLKTALIEADDFASGTSSRSTKLIHGGVRYLQKAIMQLDYEQYRMVQEALHERAVMLHQAPHLAHPLPIMLPVYRWWQVPYYWAGIKMYDLIAGRQTVKSSYFLSKKNALELFPMLRGDKLVGGLVYYDGQQDDARMNLAVAVTATVHGATIANHVSATSLIKEKRDGKDIICGVNVKDEVTGKTWSIPAKCVINATGPFTDSIRKMDNPKVKEICAPSSGVHITLPGYYSPEQMGLLDPDTSDGRVIFFLPWQRHTIAGTTDLPCKVTHNPKPTEDEIMFILEEVKNYLNPDVEVRRGDVLSAWSGIRPLVSDPNKPDTQSLARNHIVHVSESGLVTIAGGKWTTYRSMAVETIDEAIKACNLTPKYKDSQTDMMVLYGAHGWTPTMYIRLVQDFGLECEVAQHLSKSYGDRAFAVAKMAALTGKRWPIIGKKLHPEFPYIDAEVRYGVKEYAVTAIDMIARRLRLAFLNVQAAQEALPDIVNIMAEELGWSEAEKQKQIKEASEFLQNEMGQNVNRASRDKIPINLSKEEIQLYIKRFQYIDKDRKGYVSINDIRRSLKQTGEKEVSGEELHDILKEIDTNMNGQVELDEYLQMMSAIKSGHVAYSRFARMAELEEIKQETELLKKKVSVERSGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3Y2</accession>
    <name>A0ABM5L3Y2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517140.1">
        <property type="nucleotide sequence ID" value="XM_050661183.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661183.1">
        <property type="protein sequence ID" value="XP_050517140.1"/>
        <property type="gene ID" value="LOC114346985"/>
    </dbReference>
    <dbReference type="GeneID" id="114346985"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="11">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="200"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="471" mass="51563" checksum="705767EA2551C210" modified="2025-10-08" version="1">MGLGPTGHMPFFCHNGDPLSQPPPAHMGIPPYQLDSKGAASMGEYGGSPQPQPLSPAEWRRLGPLLAATGLTRPPMYPFSAGQYPYPMLSPEMSQVASWHTPSMYPLSPGAGFRSPYPSTLPISTSSLPSDFYRFSPTGLIQPHPGLSPHPPHLSSHPAIVTPGPKQELPDLNHRSQVDHKNNIDGKNNQDSNEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALGREEQAKYYELARRERQLHMQLYPDWSSRANATRGKKRKRKQDPADGGNSMKKCRARYGLDQQSQWCKPCRRKKKCIRYMEAGDGNDGNQSDDNLGSCGSMGDAHTPPDDDNESLNQSMSSPGGLSALSSLTSPGGMVLPSPSTSVASPSVSVASPYMLQSPLTPHELMDVKVPMPPVSHQHQPTRNPVGTNPHDINNPLSVNQLTGQCVRNDNNDANGNKETRSIISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L523</accession>
    <name>A0ABM5L523_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tight junction-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517535.1">
        <property type="nucleotide sequence ID" value="XM_050661578.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661578.1">
        <property type="protein sequence ID" value="XP_050517535.1"/>
        <property type="gene ID" value="LOC126892113"/>
    </dbReference>
    <dbReference type="GeneID" id="126892113"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043441">
        <property type="entry name" value="Tjap1/BEGAIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664:SF4">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66066" checksum="FB1FC0FE619C2FA4" modified="2025-10-08" version="1">MDFVIDYIIEEDCGCTCKRCISHDHDVQLHIEIENLKQRLLERENHIVTMETNFLNETHKPPSGELATIKEELLTWQDKYKRLYEAHRRVQRVNQGLEDKLLKLVDVCETEKTTLTKDVATLSHKLADANYSVKKLKEDNERYKNDVSLAIQFLQCKQSNFVAHKYDSLPPEVQSQVSNYMTTKKKPEQPRVPPEIKSIKVPIPTFPPTAMVYSVPKSPNPERKTEPEPESPPVDIVSAAIMAKVLEERQRERAAVKHCDTCTCAKGVKIVHQLECHTIGTQTGEYKEMVCLRCNESVLPMTSMKIVRTSEPKTHKVVPIYPLENIEPVLNQANYNIVKVQPNNFLADKNVDITKSPSLVDSNRITSKITPSSDNVILNEIMSYQAVSTPKASENEEKHHRLCDQLKPNYEMESTSEKGESENNEDAGSAKLSSPRGPRYASLRTQVGSRNILLDNAHNNIAPVLFTRSQKPVPKESAPTPDSLETNSMLSENSTQNQQRVEDWIRSNIDNDISSSENSRSENAKAHSSETVDKARYAEMEENVKRFLFGKSEFLKTVELGKNKYKEFEGKGSAKGADTVIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L538</accession>
    <name>A0ABM5L538_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517554.1">
        <property type="nucleotide sequence ID" value="XM_050661597.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661597.1">
        <property type="protein sequence ID" value="XP_050517554.1"/>
        <property type="gene ID" value="LOC126892123"/>
    </dbReference>
    <dbReference type="GeneID" id="126892123"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="384" mass="42457" checksum="47B852821003D066" modified="2025-10-08" version="1">MGIGTVDIIETNKLRKKLERQKAEIEREERFRQWQEGDCSQSAKIMDDSIDDGNEGQFINIVAVPELKKSSNDTFSATEPSTSEVGQMRFTLPTLSRVCDQYGISNRCAAAIASATLQDIGIVTMDDCSKVVDRSKVRRERQKTRALLKNLQTGSGGGLKSIFFYGRKDKTLSQEIVGGRYHKRTISEEHISMIEEPNSLYLGHVTPSSGTGKHIATAIYDFCIKNGLNFNEVLAVGCDGTATNTGRKNGVIANLQNKLGRPLQWLICLLHANELPLRHLFAFLDGATSGPREYSGPIGKLLENCEALPPVQFEAITCIVPELEYSDLSTDQKYMYEICLAISAGQCSLNLSTRNPGKLSHARWLTAANRMLRLYIATESPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5Z1</accession>
    <name>A0ABM5L5Z1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 15-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517857.1">
        <property type="nucleotide sequence ID" value="XM_050661900.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661900.1">
        <property type="protein sequence ID" value="XP_050517857.1"/>
        <property type="gene ID" value="LOC114331304"/>
    </dbReference>
    <dbReference type="GeneID" id="114331304"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047316626" description="Leucine-rich repeat-containing protein 15-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="78158" checksum="585B6C9A2F8DDBD7" modified="2025-10-08" version="1">MILFSRWPIFIGAVFFVSNIKICNTQFYGYNPDDTDTGSDIDDTDYGYDPYASDNGYDQYDEHNDDIIADHRREQLTSCQYARIHLPTSFNDCTKVEIIDSNISDVTPAAFLNVYSTTNLKLSGNFIKTIKPGAFSGLHNLEQLDLHNNQIVNISQGIFNHLVQLKSLDLSRNKISNIDPNFLTGVIHLSSLNFSENYLKSFDGVVLGQNNYFKILNLIDNSMSFINLSKFNGEINTLDVSSNKLTFVDVCLSGLQNLNASNNQIKYLHADSCLLDATLITLDVSNNLLNEQNLMNVSKLLKLEKLNIAGNNLSFIPVNLFVNLTRLSYLNMSHNKISFLNYGALDHLNVLQSLDLSYNNLTTLKRYFHSLSALTSLYINSNKITNINSKQLLNDIRGLNIINIDSNDFNCGNLVEVIHDFKNKVFKGTVTIGSNIHGIACKEGTLQEANPDIKFKEEIIKYLEKTISAKLEKSESLQFNKSLMYDNFNKYFKNSNFYKYLEGLKNINTLNFNGTDMLKYFNQDFKNSFFYKYLESLKANENSTREFNRSLYDYFNNDFNGTYLVKYLTKLERSKGEFIDSFDNSSMFNYFNKGFKNSTFYKYLENLNSKFDNIQQKDHGTAEYLHSSSEQQGHSYFATQSVIIMLLIILVLFKVVKIYSNYNSKNLIPREQVELLDTNSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6Y2</accession>
    <name>A0ABM5L6Y2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518192.1">
        <property type="nucleotide sequence ID" value="XM_050662235.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662235.1">
        <property type="protein sequence ID" value="XP_050518192.1"/>
        <property type="gene ID" value="LOC126892623"/>
    </dbReference>
    <dbReference type="GeneID" id="126892623"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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    <feature type="domain" description="C2H2-type" evidence="12">
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        <location>
            <begin position="414"/>
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            <end position="553"/>
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    </feature>
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            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="579" mass="68033" checksum="4D517E4FD1660F00" modified="2025-10-08" version="1">MSNQSDVKEEVGETTCKREIDNEVLEDTCKIEIKDEPIRESTNDTFDFLEVNICSIKAEIKQDDGFSSNDMKTAASNLLTHHARTDKNLKQYITSTTNVNTGGQRFICIICKKPFSNNYRLELHIRIHTGKKPFACEICTKQFSTKGNLKAHMTVHTGEKPFECEICNKQFSKKHYLKLHMRVHTGEKPFECEICNKQFLRKHYLKLHMRVHTGEKPFECENCTEQFSTKAHLKLHMRVHTGEKPFECEICHKQFSTKHVLKLHMRVHTGEKLFECEICTKQFSTKQVLKWHMRTHTGEKPFKCEICNKQFLRKHYLKLHMRVHTGEKPFECENCTEQFSTKAHLKLHMRVHTGEKPFECEICNKQFSTTQILKLHMRTHTGEKPFKCEICNKQFLRKHYLKLHMRVHTGEKPFECEICNKQFSTKSPLKRHVRVHTGEKPFECEICNKQFSTKQVLKLHMRVHTGEKPFKCEICNKPFSLKANLTMHMTLHTGEQPVACEICTKQFSTKGSLKRHMILHTDDKPFKCEICNKQFSRKLYLQSHMIVHTGEKPFECEICNKQFSAKQVLKSHMIVHTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L724</accession>
    <name>A0ABM5L724_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518237.1">
        <property type="nucleotide sequence ID" value="XM_050662280.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662280.1">
        <property type="protein sequence ID" value="XP_050518237.1"/>
        <property type="gene ID" value="LOC126892650"/>
    </dbReference>
    <dbReference type="GeneID" id="126892650"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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        <location>
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            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="803"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="828" mass="95009" checksum="0BC4CC5C85E886AA" modified="2025-10-08" version="1">MFNQTEVKQEVAETTCKREIEIIDTQVLQDTFKTEFKEEPKTESACDTFDFDYLDVKKCPIKAEIDQDDGFPHGFSCEISSELLSQSSIFKEHMELDTEDKPFAREICAKKFSQISNLNEHMGIHTSDNSFTYESFKSFLQRSNLSKDMGIHTGDKPFACEICSKTFSLKSSLKAHVRIHTGDKPFACETCSKCFSQRSSLTDHMRVHTGDKPFVCEICVKKFSQRSTLAEHIRVHTRDKPFECEICSKRFSNRSGLSEHMRVHTGDKPFACGICSKRFSQRSTLKGHMRVHTGDKPFPCEICSKTFSLTSNLKKHMKIHTGDKPFVCEICSKSFSQRCTLEEHVRVHTRDKPFECEICSKSFSNRFGLSEHMRVHTGDKPFACDICSKRFSQRSNLKDHMRVHTGDKPFPCEICSKTFSLTSNLKKHMKIHTGDKPFECEICSKSFSNRSGLSEHMRVHTGDKPFACDICSKRFSQRSRLKDHMRVHTGDKPFPCEICSKTFSLTSNLKKHMKIHTGDKPFECEICSKSFSNRSGLSEHMRVHTGDKPFACDICSKRFSQRSNLKDHMRVHTGDKPFPCEICSKTFSLTSNLKKHMKIHTGDKPFECEICSKSFSNRSGLSEHMRVHTGDKPFACDICSKRFSQRSNLKDHMRVHTGDKPFPCEICSKTFSLKSSLKAHMRIHTGDKPFECEIGSKCFSQRSSLKDHMRLHTGDKPFVCEICVKKFSQRSTLAEHIRVHTIDKPFECEICSKSFSNRSGLLEHMRIHTGGDKPFVCEICSKSFSQRCTLEEHVRVHTDDKLFACEICFKRFSQRCGLAKHMRVHTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8W5</accession>
    <name>A0ABM5L8W5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050518880.1">
        <property type="nucleotide sequence ID" value="XM_050662923.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662923.1">
        <property type="protein sequence ID" value="XP_050518880.1"/>
        <property type="gene ID" value="LOC126892970"/>
    </dbReference>
    <dbReference type="GeneID" id="126892970"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF234">
        <property type="entry name" value="ZINC FINGER PROTEIN 281"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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            <end position="207"/>
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            <begin position="208"/>
            <end position="235"/>
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            <end position="263"/>
        </location>
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        <location>
            <begin position="264"/>
            <end position="291"/>
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            <begin position="320"/>
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            <end position="375"/>
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            <end position="403"/>
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            <begin position="404"/>
            <end position="431"/>
        </location>
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        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
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        <location>
            <begin position="460"/>
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        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="512" mass="60030" checksum="F8AD1F97351E8995" modified="2025-10-08" version="1">MEVKQEYGEDTCKAEIYSNNADDDALLNTFKCGIKEEPNRESTHGTFDYLDLKEFPIKTKTKDESELLQFEEKQRKEKDSRIKAEIKEDFDEGNPADIESQLSTSLDLGVFEHEYTSGLSQMKLVELEVMKRIPEDSNNKKQISVNPEETALKNSIYAKDLPDKQNLKQHTEGWIGERHECETCFKQFNQARNLERHCLKVHNGERSHKCDICSKEFTTAGTLKRHMRVHTGEKPYNCEICFKQYSYSIDLKRHLIRHTGEKPYKCELCFKQFSDSRYLKTHVRVHDEEKPHKCEICLKQFNKAGTLKQHTITHTTETAFKCDICFKTFTTAGKLKIHLRVHTGEKPYKCDICLKQFSYKNSLDIHKTGHTGEKPYKCEICSKQFTQEGSLKIHLRIHTGEKPYKCDICLKQFSYKNSMDIHKTGHTGEKPYKCEICFKQFGRNGHLKEHWRVHTGEKPYKCEICSKQFSATGSLKRHLIRHTGEKPYKCEICFKQFRDSHYLKRHSWIHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L985</accession>
    <name>A0ABM5L985_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518994.1">
        <property type="nucleotide sequence ID" value="XM_050663037.1"/>
    </dbReference>
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        <property type="gene ID" value="LOC126893092"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58359" checksum="E24BB2F2DE10733F" modified="2025-10-08" version="1">MAQRFNVSALLFENDVSWKNIEKIYGNNVSTKDIVNLSISDDGEVSSFEIDPYLCRDSSNVQKFAAIASSEDSNNDDENDKNFELPVHLKQISSESDSYSISDEKNNTSHPEKSTNKILESKNQRKKITLCKFCQNDFMSRNFVRHMQTFHGEEKEVIKLLQYPKNSKARRAAFKLLRNETNFDLYIQGDIRPTRSLTETQTSNFYPSIYCRGLYKKSYLKRHNRICKQKNRGGSSSNYVSESQTLTACVMDPTNVVSKLIVKEQVFDKMKGDDIAFEAKKDLLIVNFGNSYLKNIRERYILRPKNFDAILSAARVLCGYNSIKKIISSPSIALHLGTYLKLCCNELLHLILKEAPGFTCTTKDECKNCQRDIHNLRTLLENRWSLEIASLANKDIQEKKMENAKARTTSLVILFNTRRIGDVQYLKIQQYSSERKTDFSDFENVLTEGEKAITREYKRIVCSGKGSRAVVILLPKMLQGFIETLIKHRHKYIATIMTMCLQFQAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LB81</accession>
    <name>A0ABM5LB81_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Regulator of G-protein signaling 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050663738.1"/>
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        <property type="protein sequence ID" value="XP_050519695.1"/>
        <property type="gene ID" value="LOC114330742"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEP_dom"/>
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        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
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        <property type="entry name" value="GGL_sf"/>
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        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
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        <property type="entry name" value="RGS6/7/9/11_DHEX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040759">
        <property type="entry name" value="RGS_DHEX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034483">
        <property type="entry name" value="RGS_Egl-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF6">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="350"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="57512" checksum="1713078DB530CF05" modified="2025-10-08" version="1">MVTMNSEKAATKRKPESNNESCTKLNNDSLIQSTTTSDESPNNILYKKMEKIVENMQDETNGVPVRTVKSFMSKIPSVFTGSDLIMWMMKNLDMEDQQEALHLANLMSSHGYFFPIDDHMLTIKNDNTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKTRLELADYEAENLARLQKMFSRKWEFIFMQAEAQSKVDKKRDKLERKVLDSQERAFWDVHRPMPGCVNTTEIDIKKACQMHKPTHAAKTVTISSKLLPSTSGLPSKNSKEQLKKQLNWLKSRLDRRNIKISKAAESFIAFYEQYLEYDSFFVAPEYPNPWISDNPDLWEQDKMAKDISARRVKRWAFSLQELLYDPIGREHFIRFLDKEFSGENLRFWEAVQELKTLPQGQVQEKAIEIWNDFLAPEASCPINVDSHSNEMTKKNMEIPDRWGFDCAANHVYHLMKSDSYSRYLRSEMYKEFLNGSKKKASVKGIRSIVSFSARKDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EX79</accession>
    <name>A0A6P7EX79_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amyloid-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114324187</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127744.1">
        <property type="nucleotide sequence ID" value="XM_028271943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EX79"/>
    <dbReference type="FunCoup" id="A0A6P7EX79">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271943.2">
        <property type="protein sequence ID" value="XP_028127744.1"/>
        <property type="gene ID" value="LOC114324187"/>
    </dbReference>
    <dbReference type="GeneID" id="114324187"/>
    <dbReference type="KEGG" id="dvv:114324187"/>
    <dbReference type="InParanoid" id="A0A6P7EX79"/>
    <dbReference type="OrthoDB" id="6147836at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019745">
        <property type="entry name" value="Amyloid_glyco_intracell_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019543">
        <property type="entry name" value="APP_amyloid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF15">
        <property type="entry name" value="AMYLOID-BETA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10515">
        <property type="entry name" value="APP_amyloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00320">
        <property type="entry name" value="APP_INTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="12">
        <location>
            <begin position="277"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="8">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028127744.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="82631" checksum="77EBC331B41E9F30" modified="2020-12-02" version="1">MLCDSGMHGQEAYHPKYMTEQGEWVSDLYSKATCYKDKMDILNYCKKVYPKRDITNIVESSHYLKIGAWCRAGSSTGAQTRGKCKTARWVKPFRCLEGPFQSDALLVPENCMFDHIHNQSNCWTFGRWNSTAGNACQEKGLQLRSFAMLLPCGISLFSGVEFVCCPKHFKDNLKPKKPVDLTILKKEQEAFDTVDDDDDEESEEEIDKDDLEDLADETELSDDPTIDDEDDDDDDDIYDEDIDWDTTPSSTTAGYKSTVPSTTPSTTTTERTTTIATPDPYFTHFDPRNEHESYKQAQERLEETHREKVTRVMKDWSDLEERYQDMRQTDPRGADEFKQRMTQRFQQTVQALEEEGDAEKHQLAAMHQQRVLAHINQRKKEAMSCYTQALNDVPPNTHRVQKCLQKLLRSLHKDRAHAISHYRHLLANSIEAAAREQPRTLERLTDIDRTVNQSMQMLQRYPDLAAKIGQLMDDYIQALRSKDETPGSLLAMTSDAEQAILDKYKSEVATKQAERERQRIQEKERKEQRKKEKSELKEEKKRVEEALGKKISNFDDEDMEDESLPEEKTSTTSLPTSGITFSEIMSNSITATSENHNVDDAAVQEAVEQVAKAASHRQDIIRVAHVMSHDISHGEPTYSVRREIFARKDGKSVYFTLAFAGMALMAALVVGVAVARRKTARSPQSQGFVEVDQAATPEERHVANMQINGYENPTYKYFEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZ72</accession>
    <name>A0A6P7EZ72_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI transamidase component PIG-T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114324285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127887.1">
        <property type="nucleotide sequence ID" value="XM_028272086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZ72"/>
    <dbReference type="FunCoup" id="A0A6P7EZ72">
        <property type="interactions" value="1289"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272086.1">
        <property type="protein sequence ID" value="XP_028127887.1"/>
        <property type="gene ID" value="LOC114324285"/>
    </dbReference>
    <dbReference type="GeneID" id="114324285"/>
    <dbReference type="KEGG" id="dvv:114324285"/>
    <dbReference type="CTD" id="31772"/>
    <dbReference type="InParanoid" id="A0A6P7EZ72"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028350550" evidence="1">
        <location>
            <begin position="19"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028127887.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="62868" checksum="55E3EB242671ADB9" modified="2020-12-02" version="1">MKHIKLIFCIFLFNSVFSYDGKITEELLIKPLHSEQVYTHFQFSTLWDIDPDQENFRHSPIFPRPIGELIQRFGIQELHISLTGGLWRYESWGYPVEDAASGAEVWVWFKPSVTEVDKNWKLLANSLSGLLCASLNFIDSSNTISPEFSLRPKGVVESSHLNNTHVRYATLPQEIVCTENLTPWKKLLPCGSKTGLASLLNSGYIHNTRYHSIGLHLRPVCRDKSCTSLSLELQQTVSLVYDYLILGTKNWSLRKLFGLGVNKKCVLVDKSEVYVDTTDQSIELEPSPDETVTSIRGGQTSILQKYVVSNQFLNIYAKYTNPDTLSLNLPPPLHANQYLSGYGQERGGIVTKIFNNHWQELDVVLMQNIPWFIPIYLHTLKVTANGKDIKPLQLRYIPARQRERPNYLEVLIRIPPSAATSVVVDFDYVFLKWQEYPPDANLGFYIGSAVVSSYLPVARNYTGIPQDGTLISDSFNASRSGYLVRVRTENIVITLPTPDFSMPYNVICLACTVVALAFGPLHNITTRKLVVKPKKGASLVEKVKGFIGKFKKEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0K1</accession>
    <name>A0A6P7F0K1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter G family member 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325274</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <tissue evidence="12">Whole insect</tissue>
        </source>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_028129094.1">
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        <property type="nucleotide sequence ID" value="XM_050648942.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P7F0K1"/>
    <dbReference type="FunCoup" id="A0A6P7F0K1">
        <property type="interactions" value="9"/>
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    <dbReference type="EnsemblMetazoa" id="XM_028273293.2">
        <property type="protein sequence ID" value="XP_028129094.1"/>
        <property type="gene ID" value="LOC114325274"/>
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        <property type="protein sequence ID" value="XP_050504899.1"/>
        <property type="gene ID" value="LOC114325274"/>
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    <dbReference type="GeneID" id="114325274"/>
    <dbReference type="KEGG" id="dvv:114325274"/>
    <dbReference type="CTD" id="43186"/>
    <dbReference type="InParanoid" id="A0A6P7F0K1"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC2_TM"/>
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        <property type="entry name" value="RE14039P"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM2"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="639"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="666"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="697"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="29"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="512"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028129094.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="85460" checksum="A482EBCB89E2F8B4" modified="2020-12-02" version="1">MERPSDIELRRRQFKTQASTLNSRRQQAVCVRRAVKKYGTKSNPYVILDNLNMTVPKGCIYGLLGASGCGKTTLLNCIVGRKRLNSGELWVLGGTPGSRGSGVPGPRVGYMPQETALNGEFTIRETLKYFGWISRMTTDEVEAKVDFFINFLMLPDADRQVKTLSGGQQRRVSLAATLLHEPELLILDEPTVGVDPLLRTNIWNHLVEITKYGRTTVIITTHYIDETRQAHLIGLMRGGYFLAEESPERLITQFGVDSLEDVFLKLSVMQNMGKRRRSSIAKSVVETITVPELGGAVNPAAVLDDDLGEISGEFGDSVSVTSRTGRRVSIAPEPTAEHIIPELPPDEEPEVSFKDYFKFVQSHHMRALIWKNFLWMWRNIPMMMFIIGLPISQTILFCWTIGHDPQGIKVSVVNNEINFPDETCHQQPLNCNGTKISCNYLNEVAKSYSITWEFMKTEEEARHRVERGKSWGVVVVPHNFTDALWSRIENSRDTPPEDIMASTISVYEDKSNENIATFLTRDMLYGFLTFISEFVKSCGYNEKSVGVPIRYNEPIYGYQDPDFTDFAAPGVVLTIIFFMAVALTSGSMIMERNEGILERSLVNGISGTELLFSQIITQFVVMLGQSIAVLLVAFILFGLTQRGDWTTVTTLTVLAGICGMCFGFVVACSCENERSATYLAMGSFLPIVMLCGIIWPIEAMHKYISWMSVVLPLTQATESLRCILARGWPISNPTVYNGFISLTIWIFIFLTISILLLKFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F625</accession>
    <name>A0A6P7F625_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Proton-coupled amino acid transporter-like protein CG1139 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC114326915</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131180.1">
        <property type="nucleotide sequence ID" value="XM_028275379.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028275387.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_028275393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131202.1">
        <property type="nucleotide sequence ID" value="XM_028275401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F625"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275379.2">
        <property type="protein sequence ID" value="XP_028131180.1"/>
        <property type="gene ID" value="LOC114326915"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275387.2">
        <property type="protein sequence ID" value="XP_028131188.1"/>
        <property type="gene ID" value="LOC114326915"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275393.2">
        <property type="protein sequence ID" value="XP_028131194.1"/>
        <property type="gene ID" value="LOC114326915"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275401.2">
        <property type="protein sequence ID" value="XP_028131202.1"/>
        <property type="gene ID" value="LOC114326915"/>
    </dbReference>
    <dbReference type="GeneID" id="114326915"/>
    <dbReference type="KEGG" id="dvv:114326915"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF340">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
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            <begin position="147"/>
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        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="305"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="393"/>
        </location>
    </feature>
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            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028131188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028131194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131202.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52086" checksum="DB994B40BD7B9E7B" modified="2020-12-02" version="1">MDNDQMKLEPMGPKDVEESSGLLNKGGRQNNQSAENGGDDFDPHMYRQNDHPTTNMETLIHLLKGAIGTGILAMPEGFKLAGMINGIVSTIVIGLLSTYCLRVLVQAQYELCKRKRVGLLTYPDSMRVACEVGPKPLRRFAPYAPGITNFFLIVYQIGICCVYVVFVGVNIKAVCDEYIKPEINQTLYILMFFIPFLLIMMLRNLKLLVPFSYLANFITLLTFGVCGYYVFQNLPSFSSLPAFGPLDKYPLYFGTCLFSLQAVGVVISLENNMATPKSFLTPFGVLNVGMILVIFVYVFLAMMGYWRYGDGIKPSITLNFPSKDVLAQVIRILYSTAIYISYGLQGFPAAQILFTTYILPHLGPAPSEKKKLIYEYILRFAIVFLTFALAISVPLLGLFISLVGAFCLSALGIAFPAIIEMSAYWPDRLGRGNIIFWKDIVLILIGLIGLVVGSYSCIYAIVQALAAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCT2</accession>
    <name>A0A6P7FCT2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">52 kDa repressor of the inhibitor of the protein kinase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114328728</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133471.1">
        <property type="nucleotide sequence ID" value="XM_028277670.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133472.1">
        <property type="nucleotide sequence ID" value="XM_028277671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCT2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277670.2">
        <property type="protein sequence ID" value="XP_028133471.1"/>
        <property type="gene ID" value="LOC114328728"/>
    </dbReference>
    <dbReference type="GeneID" id="114328728"/>
    <dbReference type="KEGG" id="dvv:114328728"/>
    <dbReference type="OrthoDB" id="8948150at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028133472.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12850" checksum="C32991F68F39A545" modified="2020-12-02" version="1">MASRGGTKCAYFNCSSKTGQGISLFCFPKDQQRIEMWLRACNREDLLDKSCEALSKNFKLCEKHFAEPCFVGTGKKRKHIMSDAVPTLFAHIDDDKEPIRKHIILRGKHSGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFF0</accession>
    <name>A0A6P7FFF0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 37A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114328863</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133627.1">
        <property type="nucleotide sequence ID" value="XM_028277826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFF0"/>
    <dbReference type="FunCoup" id="A0A6P7FFF0">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277826.2">
        <property type="protein sequence ID" value="XP_028133627.1"/>
        <property type="gene ID" value="LOC114328863"/>
    </dbReference>
    <dbReference type="GeneID" id="114328863"/>
    <dbReference type="KEGG" id="dvv:114328863"/>
    <dbReference type="CTD" id="31006"/>
    <dbReference type="InParanoid" id="A0A6P7FFF0"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF25">
        <property type="entry name" value="EG:115C2.5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="242"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028133627.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37271" checksum="75457A7A92A4537D" modified="2020-12-02" version="1">MLPRLFKADDIRKHQINTLKIFNENVTEVIESEEYDVLFSSGGNNLCLKISLVKEFPSEKPLLKVVPSVVHHWISGDGDITTAPGLLNWTVHSDLGRVVQAIIREFQRNPPPLVISHSINMSPTSPINGEIRASPVNYQTFTNIKNFSPPSHSTQSTSFQSLAIPDLSTLNLEELKFLSENPDRQDEFIDEMPLIKEQNKALGDIIQQVEEMAEANLTREEKLHELQKCVGTTIEELAKLAFENERLHTIYQQLYDKYAPRNIQGQLKIEAEKADKESEKIAESFLGGETDVDKFVNDFIRVKTLSQSRKTKEEKLGQQLDRLEKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFT4</accession>
    <name>A0A6P7FFT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114328968</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028133772.1">
        <property type="nucleotide sequence ID" value="XM_028277971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFT4"/>
    <dbReference type="SMR" id="A0A6P7FFT4"/>
    <dbReference type="FunCoup" id="A0A6P7FFT4">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277971.2">
        <property type="protein sequence ID" value="XP_028133772.1"/>
        <property type="gene ID" value="LOC114328968"/>
    </dbReference>
    <dbReference type="GeneID" id="114328968"/>
    <dbReference type="KEGG" id="dvv:114328968"/>
    <dbReference type="InParanoid" id="A0A6P7FFT4"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000005">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000153">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF13">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028133772.1"/>
        </source>
    </evidence>
    <sequence length="849" mass="97587" checksum="158275D5AAF342EE" modified="2020-12-02" version="1">MATPQSDIERRKQISVRGIAELDDVNEIKKTFNRHLHYTLVKDRNVATTRDYYFALAHTVKSHLVSRWIRTQQYYYEKDPKRVYYLSLEFYMGRSLQNTMINLGIQTPVDEALYQLGLDIEELEDVEEDAGLGNGGLGRLAACFLDSMATLGMAAYGYGIRYEYGIFAQKIVNGEQQEEPDDWLRYGNPWEKARPEYMLPVNFYGNVIDTPEGKKWVNTQVVFALPYDNPIPGYQNNVVNTLRLWSAKSPVDFNLKFFNDGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRFKSAKFGTREATRTNFDLLPSKVAIQLNDTHPSLAIPELMRILIDIEGLPWEKAWDITVKTCAYTNHTVLPEALERWPVSMLESILPRHLQIIYHINFLHMQAVEKRWPKDMDRMRRMSLIEEDGEKRVNMAHLSIVGSHAVNGVARIHSDIIKADLFKDFYELSPEKFQNKTNGITPRRWLLLCNPGLSDLISDKIGEDWTVHLDQLQKLKKWAKDPNFQRAVMKVKQENKLRLAQLLEKDYGVKINPSSMFDIQVKRIHEYKRQLLNCLHIITLYNRIKKNPSAKFTPRTIMIGGKAAPGYYTAKKIIKLINMVGNVVNNDPIVGDKLKVIYLENYRVTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLNGALTIGTLDGANVEMAEEMGNENIFIFGMTVDEVEALHKKGYNAMDYYNAIPELKQVVDQIQNGFFSPGNPDEFRDIADILLKYDRFLLLADYEAYIKKQDEVSAVYQNQAKWLEMAINNIASSGKFSSDRTIIEYGKDIWGVTPNYEKLPDPSVPRELALKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGJ5</accession>
    <name>A0A6P7FGJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DEAH box protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114327797</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028132308.1">
        <property type="nucleotide sequence ID" value="XM_028276507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGJ5"/>
    <dbReference type="FunCoup" id="A0A6P7FGJ5">
        <property type="interactions" value="2664"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276507.2">
        <property type="protein sequence ID" value="XP_028132308.1"/>
        <property type="gene ID" value="LOC114327797"/>
    </dbReference>
    <dbReference type="GeneID" id="114327797"/>
    <dbReference type="KEGG" id="dvv:114327797"/>
    <dbReference type="CTD" id="1665"/>
    <dbReference type="InParanoid" id="A0A6P7FGJ5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="65"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="254"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028132308.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="81177" checksum="D71F97117D3AFDA3" modified="2020-12-02" version="1">MSKRRIDVMDPFIKKKREERGISTAVTTTSVSVNPYSGLPFTQKYHELFRKRICLPVFEYRADFMRLLSDHQCIVLVGETGSGKTTQIPQWCVEYSRTVGQKGVCCTQPRRVAAMSVAQRVSEEMDVALGQEVGYSIRFEDCSSAKTILKYMTDGMLLREGMSDPMLDAYQCILLDEAHERTLATDILMGVLKEVIKQRKDLKLVIMSATLDAGKFQHYFDNAPLMNVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIAGDILLFLTGQEEIEVACKRIKREIDNLGPEVGELKCIPLYSTLPPNLQQRIFEDPPPNKANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTKPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMAEFPLDPQLAKMLIASCNHNCSNELLSITAMLSVPQCFVRPNEAKKAADDAKMRFAHIDGDHLTLLNVYHAFKQSMDDPQWCYDNFVNYRSLKSADNVRQQLSRIMDRFNLKRTSTEFTSKDYYINIRKALVNGFFMQVAHLERTGHYLTIKDNQIVQLHPSTCLDHKPEWVIYNEFVLTTKNYIRTVTDIKPDWLLKIAPQYYDLNNFPQCEAKRQLEIIQNRLESKQFQQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH44</accession>
    <name>A0A6P7FH44_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein mago nashi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114330132</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135246.1">
        <property type="nucleotide sequence ID" value="XM_028279445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH44"/>
    <dbReference type="FunCoup" id="A0A6P7FH44">
        <property type="interactions" value="2111"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279445.2">
        <property type="protein sequence ID" value="XP_028135246.1"/>
        <property type="gene ID" value="LOC114330132"/>
    </dbReference>
    <dbReference type="GeneID" id="114330132"/>
    <dbReference type="KEGG" id="dvv:114330132"/>
    <dbReference type="CTD" id="37402"/>
    <dbReference type="InParanoid" id="A0A6P7FH44"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028135246.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17159" checksum="8FE82BB4881A40BC" modified="2020-12-02" version="1">MADFYIRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDTMIRKEVYVHQCVMEELKRIIIDSEIMQEDDSLWPPPDRIGRQELEIVIKDEHISFTTSKTGSLIDVSQSKDPEGLRCFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ87</accession>
    <name>A0A6P7FJ87_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114328431</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028133083.1">
        <property type="nucleotide sequence ID" value="XM_028277282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJ87"/>
    <dbReference type="FunCoup" id="A0A6P7FJ87">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277282.2">
        <property type="protein sequence ID" value="XP_028133083.1"/>
        <property type="gene ID" value="LOC114328431"/>
    </dbReference>
    <dbReference type="GeneID" id="114328431"/>
    <dbReference type="KEGG" id="dvv:114328431"/>
    <dbReference type="InParanoid" id="A0A6P7FJ87"/>
    <dbReference type="OrthoDB" id="10023921at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="5">
        <location>
            <begin position="181"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028133083.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="71797" checksum="EEF82A9E0F42537C" modified="2020-12-02" version="1">MNNYMQRLGLTAWRKKTTILVAVGFLSLIIFGLQFSNLEEKSPNLNNLLQEERDDEMVAAAVAKSIKNVRFIEANRNRIPATEIDAEMIQSNKNDVRRDVKSEKQFEKLQMEQQLGVPFVNIDPKNPYIPNNRLVHLDLKGAPPLIVYLKKFFPLIKSMGATGILLEYEDMFPFSGTLKNISSKNAYTVENIKEILSLAENSQLEVIPLIQTFGHVEFALKHAEFAYLREVNGSPQALCPSRKSSLNFIAEMVNQVMALHPSVKYLHIGCDEVFQMGECDLCRLEIHENLFLKHIKNIVDIVRLNYPKLKIIIWDDMLRHISQQSMFDAKLGELVEPMVWVYAEDIYRFVQPTVWEKYAAVFPTAWTASAFKGAFGETLYVPNARRHLENSLRWLDTMAAQSPSFKDGLAGIAITGWQRYDHFAVLCELLPASLPSLALNLLAVTTGYFNLSLRDKFLKALHCPEPSIDSSPFIMLESDPFLWEKVSRCTFPGSPVFRLTNRFHNLELEAKEFLDVTTKQKGWMTAYNIRHNYSLALRVEELTIDLPRLYHGMISLARATVDAMDEIFDNYTITEWIEQKIYPYILEFEKIQNDSVVLKSVNHWPSRPLPLSKEMQKLVLNIGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKU0</accession>
    <name>A0A6P7FKU0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114330472 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330472</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135617.1">
        <property type="nucleotide sequence ID" value="XM_028279816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279816.2">
        <property type="protein sequence ID" value="XP_028135617.1"/>
        <property type="gene ID" value="LOC114330472"/>
    </dbReference>
    <dbReference type="GeneID" id="114330472"/>
    <dbReference type="KEGG" id="dvv:114330472"/>
    <dbReference type="InParanoid" id="A0A6P7FKU0"/>
    <dbReference type="OrthoDB" id="5396515at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="122"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135617.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="47601" checksum="43A0DC0F418E0744" modified="2020-12-02" version="1">MKFNMDILPVLKEVFYSQNLKFFDVKIDENSQRSFHMGSHLLFAKVSIIDQQENAREIPLAVKVGKTKLDSSMVATGCRESAFFREIVPIFNKLQTDLKIKNIFNKIPKCYRTLMKDGYEIIILENLSFSGWGVIDSFVSLNAEGQEVIAKNIAQYHALSFALRHIDKQTFDKHATDFNMTNREVMVKINDVFQDLLCKIIENTLEETNKQEMLSKFRILMKNVNEQTMLNIVDDLPKEVVVVHGDLHKFNLMYKFKDKSSGSIVDAMFIDFQDSRIHSPVLDLTYYFFFSVQIPFKASDFLKYYHQELTTYLRDLTCDANKLFPYSTLIEHWNKYAFYGFCCGVTYVTLEFAVGTLQKPSNGTIESVEEPVDMDKTIRNACLNPEVTNNGLYKQSLINLTENYLESINIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMT0</accession>
    <name>A0A6P7FMT0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide chain release factor 1-like, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329430</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134330.1">
        <property type="nucleotide sequence ID" value="XM_028278529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMT0"/>
    <dbReference type="FunCoup" id="A0A6P7FMT0">
        <property type="interactions" value="1812"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661807.1">
        <property type="protein sequence ID" value="XP_050517764.1"/>
        <property type="gene ID" value="LOC126892297"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FMT0"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134330.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44985" checksum="F57505C845E6D4CA" modified="2020-12-02" version="1">MFMFRKSLKYFKLLNGIRGSDMYFKKKFSAIPNYELDLNVNGTSLNNYIKKLQTEFEILNRDAINNKRKMELQPIIQILTDRKALVSNIHNLRELLEEKDMDIKKLAEEEKLSFENQLKELDEHLLKSLIPIEKENFHNSIILEVQAGVGGQEAMLFAKEMFDMYCNFVEYKGWQYDMTEYGDTDLGGIRYASALVTGPSVYRYFKHEAGVHRVQRTPATEKGGRIHTSTISVIALPQPSDIEVNINPNDLKIETKRSSGAGGQHVNKTESAVRIVHLPTGIAVECQVDRSQIKNRKLAMAKLSAILYQRQEEAQSSKIEAAKKSQVNTRNRNEKIRTYNFNQDRITDHRLGVNVHNLKVFLEGGEPLDNLIQKLDEQYSLSTLLNLVETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNF8</accession>
    <name>A0A6P7FNF8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcription factor Dp-1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114332274</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137849.1">
        <property type="nucleotide sequence ID" value="XM_028282048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNF8"/>
    <dbReference type="FunCoup" id="A0A6P7FNF8">
        <property type="interactions" value="1356"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282048.2">
        <property type="protein sequence ID" value="XP_028137849.1"/>
        <property type="gene ID" value="LOC114332274"/>
    </dbReference>
    <dbReference type="GeneID" id="114332274"/>
    <dbReference type="CTD" id="13450"/>
    <dbReference type="InParanoid" id="A0A6P7FNF8"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14458">
        <property type="entry name" value="DP_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000047">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.80:FF:000001">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="9">
        <location>
            <begin position="268"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028137849.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52979" checksum="C168CBE4A5AD6E5A" modified="2020-12-02" version="1">MTQQTNTTNWVIQGTNGQPQMIKMMPLSGVSGKTFSGIMTSAMSGQQLKIIKTSPATIADETQQIYASNISPANHILRTIGGSRVVTKTVPLQVNKLPSGLKTIKLATSQMPGIKISPAANSIKVQLSPQLNSTSTTVPVYTSQPSTMPKNSTPPILSRKRQDHVELDYAPESKRPRKSDKVGKGLRHFSMKVCEKVQQKGTTTYNEVADELVTEFTNSTNNSLADQYDQKNIRRRVYDALNVLMAMNIISKEKKEIRWIGLPTNSLQECHQLEKDVQKKIASIVEKEKQLTELILNQIAFKNLAQRNRDNEKFYGAPSSNSSIQLPFIVVNTNKKTVISCSISNDKREYVFQLNDTFEIKDDMEILKSIGMLSGLDTGTCSLESLEKIKGLIPESMWPYLDKIYNGTHHSLEQLLDEANAGTSSLSMLNADEFVEARLDEENSRQSSSFDPLSPSPHEFSEDEAESDISSDNDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSV2</accession>
    <name>A0A6P7FSV2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trichohyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114330672</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135880.1">
        <property type="nucleotide sequence ID" value="XM_028280079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSV2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280079.2">
        <property type="protein sequence ID" value="XP_028135880.1"/>
        <property type="gene ID" value="LOC114330672"/>
    </dbReference>
    <dbReference type="GeneID" id="114330672"/>
    <dbReference type="KEGG" id="dvv:114330672"/>
    <dbReference type="InParanoid" id="A0A6P7FSV2"/>
    <dbReference type="OrthoDB" id="10042846at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039183">
        <property type="entry name" value="CCD66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040467">
        <property type="entry name" value="CCDC66_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22736">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22736:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15236">
        <property type="entry name" value="CCDC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC66" evidence="3">
        <location>
            <begin position="162"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028135880.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="82063" checksum="837D52E4E9AA4D6A" modified="2020-12-02" version="1">MSTTSDSALSLVERKKLQWAREKEELAALNSSWSADQNCRPFDRNPRQTKRRSSLPPLYKNQYNSYDREKEIGGETSGYGSDNPNQSPDYVQTWNNNNQSGYESSSSRDDRMKWGDKAFEKSDLHEPPNWVKRGLKGGEIIVNNTSPAESPEQRYEEDRPQTGSSYSQNRYTYLRGQNIPIDSVEMAERERRRQLAIAHQEAIRLQLEEREKRRKEEKERRIKEEYEEELRIEREQEMERKRKEQELQILQEKQERDRKRKEAIQEAIELAQKEAQLVKMRKNKNHFINTDVDEKNSEPKGKFAELPNVDKNPEVATFDNKEKKSNSEQLNNTKILPPRSDSVNNDINNNLEIRGKSISPRQIKDTENNAKIVSPRNNTIENQTATPSTSFTNLLSTPRIENNLALVIPAPIENLQNLQYALLIPTTPQNVKFPPAEVITRTENRILTPTQFRDRNKKFCDSSTQTDESVFVRTESSCDNREKVTREKLTNLDLSYDNRNRKERRSRSESLEERPKWGVNRPPTRYIKQSEKDPLYQRRKLRQKQRESKTYDDKNSSDESQTASPRSYRKKGCMDKRHSRSQWKKDEVYTRNIRMYQTEIIPLESDKDHIYYKRSDCCCFCRCGRHRCSDGSLKVDILKIDHHSPRDAHMERTDKLPEIDVNEDMLDKLSSLHNGLLMKQEQWDSMRMSSPAASTSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVC0</accession>
    <name>A0A6P7FVC0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Protein kinase C</fullName>
            <ecNumber evidence="2 16">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC114331493</name>
    </gene>
    <organism evidence="27">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="27">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2 16"/>
    <dbReference type="RefSeq" id="XP_028136883.1">
        <property type="nucleotide sequence ID" value="XM_028281082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVC0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281082.2">
        <property type="protein sequence ID" value="XP_028136883.1"/>
        <property type="gene ID" value="LOC114331493"/>
    </dbReference>
    <dbReference type="GeneID" id="114331493"/>
    <dbReference type="KEGG" id="dvv:114331493"/>
    <dbReference type="CTD" id="43428"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20835">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20838">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04014">
        <property type="entry name" value="C2_PKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05591">
        <property type="entry name" value="STKc_nPKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000063">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000126">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000056">
        <property type="entry name" value="Protein kinase C epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034669">
        <property type="entry name" value="nPKC_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000551">
        <property type="entry name" value="PKC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 16 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="23">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="23">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="368"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="24">
        <location>
            <begin position="629"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="374"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 19">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_028136883.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="79799" checksum="FDB76FB3C807AC70" modified="2020-12-02" version="1">MFTGTIRIKVCEAQSLRPTDCSMRYTFGKPDEQLLDPYVTIAVDDIHVAQSTSKQKTCDPVWNEYFEHQVENAKTLTLTVFHDAAIPPDVFVANVSILFEDLLNRERDESDFWVDLEPKGRLHIRIDLRRTSKEYGGKPREFKERQGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCRDFIWGLGKQGYQCQVCTCVVHKRCHHTVVTKCPGMQDESSSQHQSTGFNVNVPHRFVVHSYKRFTFCDHCGSLLYGLIRQGLQCEACSLNVHKRCQKNVANNCGINTKQMAEILTQIGVSPDKQTPRRSKLLTGSGGNGGQQEGFLENSTAVSDSTAEELSKALEEKLTNSEDGGAGKKTIGLNDFHFMKVLGKGSFGKVMLAEKKNTEEVYAVKVLKKDVIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTKDRLFFVMEYVNGGDLMFQIQRAKKFDEPRARFYAAEVTLALQFLHKHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIQEGKTTSTFCGTPDYIAPEILQELEYAASVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKDAVSILKGFMTKNPSRRLGCVVAHGGEAAIQAHPFFKEIDWTALESRRVKPPFRPRIKSRRDVTNFDAEFTREEPVLTPVSNEVLQSINQEEFQGFSMVNGDFNPSRFIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWX6</accession>
    <name>A0A6P7FWX6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114331894</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137383.1">
        <property type="nucleotide sequence ID" value="XM_028281582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281582.2">
        <property type="protein sequence ID" value="XP_028137383.1"/>
        <property type="gene ID" value="LOC114331894"/>
    </dbReference>
    <dbReference type="GeneID" id="114331894"/>
    <dbReference type="KEGG" id="dvv:114331894"/>
    <dbReference type="InParanoid" id="A0A6P7FWX6"/>
    <dbReference type="OrthoDB" id="6696619at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028137383.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51476" checksum="CC5B502016D4237B" modified="2020-12-02" version="1">MDSQNVNNYFLYFSAIAANMFFVSSGTMLVWNSPVLPKLQSNNTIINPLPTPITIFETSTITMMYPLGSTIGSLLIGKIPDIIGRKKTLTCLSFVVMVSFIALSFANEVYFFFIILPILSANLAAGYIVIPTYVSEIAEDHNRGNLGTMMSFGYGFGQLYAYLIGATTSYRLFCLLCAFPPFLVLLCSLFIPESPIYATLKGRREQALIILKKLRKSKPARDVEIEYNEKEQFLLNNTIGPKISFKSFFLDRAVRKGIALSIAVFVMQKVAANYLVLSFLGTLLNDADSNLSGDKLAVLVQIIKIIAAFVVFYAVEKKGRRFLFLLGTSLCGVALFGLGSYFYFQHNGYYLNGFTRLMPVFLIIFFLVSYTLSLSSIPSILASELLPNELRSLGLSIALLFGNICLIAISFSYPIVAKYLGVHYCMYTFSCFCFIGFSIMYFVLPETRGKSFEEIRNILNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX16</accession>
    <name>A0A6P7FX16_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114335034 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114335034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140991.1">
        <property type="nucleotide sequence ID" value="XM_028285190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX16"/>
    <dbReference type="FunCoup" id="A0A6P7FX16">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285190.2">
        <property type="protein sequence ID" value="XP_028140991.1"/>
        <property type="gene ID" value="LOC114335034"/>
    </dbReference>
    <dbReference type="GeneID" id="114335034"/>
    <dbReference type="KEGG" id="dvv:114335034"/>
    <dbReference type="CTD" id="116874"/>
    <dbReference type="InParanoid" id="A0A6P7FX16"/>
    <dbReference type="OrthoDB" id="6357915at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF13">
        <property type="entry name" value="CHROMODOMAIN Y-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
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        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140991.1"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138607" checksum="FB0CEBD15427F586" modified="2020-12-02" version="1">MESSITQGYENAGVVSDVNKQISYEENTVAYGQENYPVGTQIVAEGFHVEGDPYNVSHATVYNPNESIQQMAFDQQDQNLQNLPHEAYYTSQEIQLQESCIPEQPLVQEPAVMNANQPVEVSNSEMTNEIITEINETKEEIIDNGTNNGNVDNVETNSNENIENVVEEDNNAIGTETIIQQNIDNNEEESATLKIEDSVQSEEISEQSLSGSTPVSEDILNQSSVTNITESDAVQDTLDGSLVTTEDLGESIERVSAENQVLEESVVSEEGITDMSLQISDNSVNAETVEESMHCVVPEATEIDLPIGGDLIELQNYEAENNQQVQDHYIFTEESSSAPSVSSEGIPASQTDDGTTTNSDKPTKQRRFRKPVHDLPMHLIGHDISKPVEVVPNGRPLPKPRLGVKVPYLNLTSQIVSKAELEDEIIERSRQKEANSIKTRNKFARSLTQRLAHKIAPEKNVLGKKPKEEPLQDEQSDNEDDPLCPKHEPSQISALDDEKIENDDDLLAILEGDGDGEDIPVVQKESQENEADDSNLKLLEREIALQQLQELPHQEPTEKVVKPRFSRSAPALVKKETKEEKPKPKQSTPSKPTSKSPQQSKQAENQHKEEQQSKSKTQSIKKSSPTIDLPIEKKSVNIEPVPIEKKPVEIEPQVKVNMVLKTYSRKRKPSDIHDFDTPSPKRSAFEDPDANQIYEKGDPLALPSDVYVTKSSRVIKKKVIWDPDDEQTSKPASVKIVDTTKVYGAKTEKSDRKQTGTPTGDKIKSDQKTTPKSAEKNTTEKNIVKKPVAKPKTPLKSKRGLSEVDRLLMDEGAVKMLYDLKSDETPTKKKKTIYSVERAAKDIIKKANVLKNDLVQNTGGESQKTLRKKEGSGSNTSSPMVKPPLQEPVPIMERKMSKDSTRSSVHTPPRSPTFFASQTSMLIRRRSSSSLSSDSESDSQKSKTKSNKKTESSKLRKQKKSTSNDNNNSTPNKDTKNAKSSKEITAKAVKGVQYKSFTMKKSGKHIAIDLHYIDEECLFTIQVLDELTTALKRLEKDKDCNVVSITSTSKAFCLGLDYAWLVKENKNDRVEKASVMAETVREFLLCLLNFSKVLVAGIQGECTGLGVTMLSLFDTVIASDTATFRTPYASLGCLGEATFLLTYPNLNSNGLAAELLYAQQVLKADEAFRRGLISKLCWPEKYKDTLNNFLTSVAKGSRQSLEATKRRLRVNTRDQIEAAINDEVEILIDHWTSPECQENFSKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXB6</accession>
    <name>A0A6P7FXB6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lectin subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114335201</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141199.1">
        <property type="nucleotide sequence ID" value="XM_028285398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285398.2">
        <property type="protein sequence ID" value="XP_028141199.1"/>
        <property type="gene ID" value="LOC114335201"/>
    </dbReference>
    <dbReference type="GeneID" id="114335201"/>
    <dbReference type="KEGG" id="dvv:114335201"/>
    <dbReference type="InParanoid" id="A0A6P7FXB6"/>
    <dbReference type="OrthoDB" id="6650247at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF465">
        <property type="entry name" value="AT17652P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027997325" evidence="2">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028141199.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18848" checksum="8EC3438522AAE950" modified="2020-12-02" version="1">MKVVYLILVLAVVTQAFSDVTRNETGRHWFTLRGKEYFIEENVKANFWTAVQYCYHHNMQLVSLGTQEENDALYNEVDQFLAGQAEFWSSGSRIANDDDWIWLTTGRPIKVFNWGDGEPNNKDKKERCISLYYRHYQNGWWNDENCDNELGVICETKCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXU2</accession>
    <name>A0A6P7FXU2_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114335275</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC114335275</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141291.1">
        <property type="nucleotide sequence ID" value="XM_028285490.1"/>
    </dbReference>
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        <property type="interactions" value="23"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050662542.1">
        <property type="protein sequence ID" value="XP_050518499.1"/>
        <property type="gene ID" value="LOC126892805"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027695197" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028141291.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16364" checksum="47C393A87EDEE79D" modified="2020-12-02" version="1">MNKIFLCFAVLCCVQQGFALLTPVSLGKHINKESKSLQANCKVLTGATQDQIDQVRQGNFNQGSNIKNYAACIYLQSRLMDKNFNFDVIMMDYFMPPKQDLYVEYLKCNLQWRNADLSFVDKLWNQIQCVYQHDPANFIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZ54</accession>
    <name>A0A6P7FZ54_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114332236</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137795.1">
        <property type="nucleotide sequence ID" value="XM_028281994.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P7FZ54">
        <property type="interactions" value="1776"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281994.2">
        <property type="protein sequence ID" value="XP_028137795.1"/>
        <property type="gene ID" value="LOC114332236"/>
    </dbReference>
    <dbReference type="GeneID" id="114332236"/>
    <dbReference type="KEGG" id="dvv:114332236"/>
    <dbReference type="CTD" id="36058"/>
    <dbReference type="InParanoid" id="A0A6P7FZ54"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028137795.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27815" checksum="87DB92CEADEA0B97" modified="2020-12-02" version="1">MPKSKRDKKISLTKTDKKGLALKQKIVEDVRESVGKFKSVYVFTYKNMRNETMKAVRQEWKPSKFFFGKNKVISIGLGRTPEEEVEDDLHKLCQVLKGQCGLLFTDCTKKEVKEWFESYFVEEYARSGFKAKTTIKLDAGPLKQFSHAIEPYLRQLGMPTKLDKGVVTLIKDFEVCKPGSVLTPEQAKILELLDHRIATFKLILKAKWTRGKGFEQFKVEDEDEDESEEQNEDEQMEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1P0</accession>
    <name>A0A6P7G1P0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114336619</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114342057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114336619</name>
        <name evidence="5" type="synonym">LOC114342057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142786.1">
        <property type="nucleotide sequence ID" value="XM_028286985.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028148657.1">
        <property type="nucleotide sequence ID" value="XM_028292856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1P0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650862.1">
        <property type="protein sequence ID" value="XP_050506819.1"/>
        <property type="gene ID" value="LOC126884732"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651691.1">
        <property type="protein sequence ID" value="XP_050507648.1"/>
        <property type="gene ID" value="LOC126885227"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6792584at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028142786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148657.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="14203" checksum="1B6C4EC0BF21420D" modified="2020-12-02" version="1">MASTSGARAELRAVLSENSSLNVNFIDDRDDSVADKDYKPSGDDFPSQSSEDELQEPIPRLFKDKEVNPEKKKPTRWRQLNEEHYDRNERKSYSILLRKPRRLLVHVKLAKKIPFYGKADLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2E7</accession>
    <name>A0A6P7G2E7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histone-binding protein RBBP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114336937</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143124.1">
        <property type="nucleotide sequence ID" value="XM_028287323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2E7"/>
    <dbReference type="FunCoup" id="A0A6P7G2E7">
        <property type="interactions" value="2461"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655026.1">
        <property type="protein sequence ID" value="XP_050510983.1"/>
        <property type="gene ID" value="LOC126887474"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G2E7"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000021">
        <property type="entry name" value="histone-binding protein RBBP4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028143124.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48362" checksum="536B1127A1351B5C" modified="2020-12-02" version="1">MGDKADAETFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDHSIHRLILGTHTSDEQNHLLIASVQLPNEDAQFDASHYDNEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCVIATKTPSSDVLVFDYTKHPSKPDPSGECHPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKENRIIDAKTVFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRCNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSPEDSEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEEPEQQASDIEATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G404</accession>
    <name>A0A6P7G404_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leukocyte receptor cluster member 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114333939</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139743.1">
        <property type="nucleotide sequence ID" value="XM_028283942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513460.1">
        <property type="nucleotide sequence ID" value="XM_050657503.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513465.1">
        <property type="nucleotide sequence ID" value="XM_050657508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G404"/>
    <dbReference type="FunCoup" id="A0A6P7G404">
        <property type="interactions" value="1855"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283942.2">
        <property type="protein sequence ID" value="XP_028139743.1"/>
        <property type="gene ID" value="LOC114333939"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657503.1">
        <property type="protein sequence ID" value="XP_050513460.1"/>
        <property type="gene ID" value="LOC114333939"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657508.1">
        <property type="protein sequence ID" value="XP_050513465.1"/>
        <property type="gene ID" value="LOC114333939"/>
    </dbReference>
    <dbReference type="GeneID" id="114333939"/>
    <dbReference type="KEGG" id="dvv:114333939"/>
    <dbReference type="InParanoid" id="A0A6P7G404"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000010">
        <property type="entry name" value="Leukocyte receptor cluster member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="497"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028139743.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="83194" checksum="0F4E245DC2221A9D" modified="2020-12-02" version="1">MNDTELASIPPPPGTIDNPPLPPEPPSSPPPPPPATEHPQTPNMFLPNQNWANYNNYMNYYQQYAQFYPYLFMSSPYQSYNQFNKKDESVQPPLPPGSPNPPLPSPMSHNIRSPLLNSPKQFGHIRFQLNSKRLPNPNSNPIMKLHSSTSGAAKKRRKRNKNNQNNAVNNQNLNMNNTPPLPPPELSLPKPAPPPPELPPEPPLPPMPVDVNPPLPPQEPQDCMAQNGLCNPSEDWPESLKDYVLRSYARCRTEFDKNQVQIILKGKITQACQNGQLYKDWGKEPLPNIHSDRQPFTGQVKTVPGQLSQFQNNKKGLSPGLGARLGSRSSIASTLRGKSKSSSRSRSRSPVPRKKSRSRSPRKNGSYSDTSTSSSEDSYKSDSKSSRRNKNKMSDRLGVSKNKNQKSSKKQKPKDKKSSFYSTFGSEVEENKEVLQQRAARFNNNKSNTSNGYDKNASFVIDKFSDDNNLSANFDWSDGHIVGTCQDLEKSFLRLTKAVNPCEIRPIEVLKLSLQNVKDKWIQKQDYFYACDQLKSIRQDLTVQGIRNEFTVEVYETHARIAIEKGDHEEFNQCQAQLILLYQNIGGSNRTEFVAYRILYYIFVKNTLDIMTVMKSLTKEEKSDECISFALKIRSAWGSGNFHKFFFLYCRAPFMTGYLLNWFIERERKDYLKCIIKSYRQSVSIDFLVQELAFENVEECFAFLEQFSLVFADSERTLLDCKSSMSALPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G613</accession>
    <name>A0A6P7G613_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114338096</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028144479.1">
        <property type="nucleotide sequence ID" value="XM_028288678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G613"/>
    <dbReference type="FunCoup" id="A0A6P7G613">
        <property type="interactions" value="1258"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648273.1">
        <property type="protein sequence ID" value="XP_050504230.1"/>
        <property type="gene ID" value="LOC126883062"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G613"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028144479.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24999" checksum="57C3C113E34B21CA" modified="2020-12-02" version="1">MSFLLLHRLIRDKIGYKAAMKVLLVTLAFVAVLAYVRSDDSSKKGPKVTDKVWFDITIGGEPLGRIEIGLFGKTVPRTVKNFRELATKPAGEGYKGSKFHRVIRDFMIQGGDFTKGDGTGGRSIYGERFADENFKLKHFGAGWLSMANAGKDTNGSQFFITTKQTSWLDGRHVVFGKILKGMDVIKKIEATETDSRDKPKQDVVIADCGAVDVDEPFSVEKADARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G766</accession>
    <name>A0A6P7G766_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114338500</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144899.1">
        <property type="nucleotide sequence ID" value="XM_028289098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G766"/>
    <dbReference type="FunCoup" id="A0A6P7G766">
        <property type="interactions" value="1005"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644470.1">
        <property type="protein sequence ID" value="XP_050500427.1"/>
        <property type="gene ID" value="LOC126880543"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G766"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000004">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028144899.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12920" checksum="20F6E241016F853C" modified="2020-12-02" version="1">MAPRYEIAVGLQRGHKTTKISDKSKLNKVRPARLKGIQTKHTKFVRDIIREVVGHAPYEKRAMELLKVSKDKRALKFLKRRLGTHIRAKRKREELSNILTQMRKQQATHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9I4</accession>
    <name>A0A6P7G9I4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein 126</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114339346</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Flattop family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145779.1">
        <property type="nucleotide sequence ID" value="XM_028289978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9I4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050660248.1">
        <property type="protein sequence ID" value="XP_050516205.1"/>
        <property type="gene ID" value="LOC126891067"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G9I4"/>
    <dbReference type="OrthoDB" id="521617at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23705">
        <property type="entry name" value="Flattop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032084">
        <property type="entry name" value="DUF4812"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038797">
        <property type="entry name" value="Fltp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34639">
        <property type="entry name" value="PROTEIN FLATTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34639:SF1">
        <property type="entry name" value="PROTEIN FLATTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22611">
        <property type="entry name" value="CFAP126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16071">
        <property type="entry name" value="DUF4812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4812" evidence="4">
        <location>
            <begin position="519"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028145779.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="67123" checksum="3CFB18110C36C4AE" modified="2020-12-02" version="1">MQYEPTFKPKVLKNWEVPKLNVDKPRRRSGKTKIIANDRGHLLPEIHKTNNNPWGNFVGTWRLPKKVDKKTAFQINGLLNKEQEQDKNIHKPTDTQSPLFEIGDKDENKENAVEQIAEAVPYVPGDLTDKEHQHPTYEKLSKNRFPTEQPLLNGFPRIRDDFSKLPEVKQDVNKEVEEFYATHKQMVQTHPSYSSPLPKKERILSPIIAAISNFNLAKKLHKENLEHNPLPDTLTDAIYRKMLLHRQGKDYEGKEHFATGVGWKGYPGYGPTRCTKLKVYRPKTSGSPKDETICSFDRKWRFIRQSKVTPMDLAICWDLTPEDPKDEPDRPKHIDGSNGSAAPAVFSLVHTPKEEDVDVKCDGLHCGTLFEHSNKGNEEKEYFFHRSKRTPPRSIHSDSEKSDGKKRAKSAIEVDKCSIDSKLSSLSAKSRAKSAYNLLEADNNSNTSKNNLNLHRSTPNLDEILEKRPKKCNKIHNKFCVACEMKNVSLTEKRPKSEYKTAFKAGVPNKIVSRPIYNLKVARPKDPYMVKNYVIDSLAPPFSFQKKKREDYPEHWRLATVYQHSYKPIYARKRPFMQTVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GET7</accession>
    <name>A0A6P7GET7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC114337278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114337278</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="13">Whole insect</tissue>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143488.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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        <source>
            <dbReference type="RefSeq" id="XP_028143488.1"/>
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    <sequence length="151" mass="17477" checksum="950B5F5D94589892" modified="2020-12-02" version="1">MNYVYLCILIVILVLVKKSEAVRCYQCGSDEDGKYEDNCGAYQKFDKLNHIAIECNSEESHMPGSFCMKFTQQSPRGFIWDGRWRQVIRRCASVADTGVTGVCNWGVYENGIYWEECYCSEDECNSAHMTKISIFSVISFIILPIMRYIWN</sequence>
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        <scope>IDENTIFICATION</scope>
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        <location>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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        <source>
            <dbReference type="RefSeq" id="XP_028149896.1"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028149897.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19937" checksum="6DAC72AECC27D33E" modified="2020-12-02" version="1">MSSRKTVSRRGTTKKRAQRATSNVFAMFDQAQIAEFKEAFNMIDQNHDGFVDKEDLHDMLASLGKNPTDDYLDGMMNEAPGPINFTMFLTLFGERLQGTDPEDVIKNAFGCFDEDNNGVLNEERLRELLTSMGDRFTDDEVDEMYREAPIKNGLFDYVEFTRILKHGAKDKDEQ</sequence>
</entry>
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    <accession>A0A6P7GQF4</accession>
    <name>A0A6P7GQF4_DIAVI</name>
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        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114340874</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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            <taxon>Eukaryota</taxon>
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            <tissue evidence="15">Whole insect</tissue>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
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        <reaction evidence="10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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            <dbReference type="ChEBI" id="CHEBI:83139"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
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        <property type="protein sequence ID" value="XP_050515400.1"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
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    </dbReference>
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        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Fatty acyl-CoA reductase"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="FAR"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF24">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sterile"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="358"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028147453.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57996" checksum="D6E1C7F82610BFAC" modified="2020-12-02" version="1">MLIAEYFTGKHIFITGGTGFMGKVLIEKLLRSCPTVGNIYILIREKKGRSIQERIESMQNLPIFQLLKKTNPDAFKKMIPIRGDVTDVDLGLSADDRKMLIENVNIIYHSAASVRFDDFLKDAILINIRGTREVAQLALETKNLDFFLHVSTTFCNTDKVVVEEKLYPPHGDWRATIRLAEECDEALLCALSEKYIRPLPNTYTFAKSLAEHVVNDMCFGKVPVVIARPSVVVSTLTEPIEGWNANFNGPVGLLVAGGKGILRTTFGNPVETSDYIPVDLAIKVIIMATVRYGGIVRESESIEVLNLAQGNIARLTLGELVQMGRKLILDTPFSTIMWYPRFSITNCWYNFYIQTVLFHMVPAFFVDLMLRLVGKKPMMFSLQRKIYIANMILQPFLSFTWIFLNDKATALRHSVTEEGFTADLDAMDKERVYDYFRKSKWGAALYILKEDFDFTRRKSRKNLRRLWYLDIAAKLILFCFLVWILTFKLQIISRVFIAVQNYYTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GW13</accession>
    <name>A0A6P7GW13_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized histidine-rich protein DDB_G0274557-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114347433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028153941.1">
        <property type="nucleotide sequence ID" value="XM_028298140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GW13"/>
    <dbReference type="EnsemblMetazoa" id="XM_028298140.2">
        <property type="protein sequence ID" value="XP_028153941.1"/>
        <property type="gene ID" value="LOC114347433"/>
    </dbReference>
    <dbReference type="GeneID" id="114347433"/>
    <dbReference type="KEGG" id="dvv:114347433"/>
    <dbReference type="InParanoid" id="A0A6P7GW13"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027966822" evidence="1">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028153941.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="12082" checksum="A332124EBD05EFF3" modified="2020-12-02" version="1">MSKVVLVSIALLCAFLVLQAAAIPTPQPGYGGGHVSHHDYDHHHHDYDHNHHDYDDHHHGHHDHHGHHYHYDYPYNGRYTQSYRYWKNYGVYPNYNQYYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GWW7</accession>
    <name>A0A6P7GWW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (34-2'-O)-methyltransferase regulator WDR6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114347772</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154246.1">
        <property type="nucleotide sequence ID" value="XM_028298445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GWW7"/>
    <dbReference type="FunCoup" id="A0A6P7GWW7">
        <property type="interactions" value="998"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298445.2">
        <property type="protein sequence ID" value="XP_028154246.1"/>
        <property type="gene ID" value="LOC114347772"/>
    </dbReference>
    <dbReference type="GeneID" id="114347772"/>
    <dbReference type="KEGG" id="dvv:114347772"/>
    <dbReference type="InParanoid" id="A0A6P7GWW7"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028154246.1"/>
        </source>
    </evidence>
    <sequence length="965" mass="110140" checksum="BE308AEFD69D8F35" modified="2020-12-02" version="1">MLQFQSQLIKTDVTAITRHEYVTLVGIGSSLHVFCNNTDKLINKINIEDTRGELIFGIKPFGHNKLLIFGGPFLLIFSADQQFTHIEEVHRVAHKDWILEAKFINNETQIATVSMQNKLQIWDTALNLLETFECQEKCILYSAHICYNDYDKLVILSGTVFNEVLLWKVRRNEYSKVPVLKRLKKHDGVIFCIHYNEDNGIICSTSDDRSAILWKVENTDLSLELNREHPNIFPICQVYGHLSRVFRCLVLKDCFITAGEDSLINIWKLDGKLARKVEANQNSPIWALDFDQTDNVVLSGGGNGGVYTFSLYNNIKKEKICLPNSEKPKIVGILLSGNFVVFSENGVLYFYSNTNWIPVKTFEDLKSYVVMKVSRCKKLIALAGFTGQIYIYKENQNTLEQLYYFQSNNKSRIISLHWLTCDMILICQDGGKLKLLYLKPSEINEVCSFTLPKSSQRISTTAIIFEDTIVAGDRKGSLHRFKIGQDCPIQTISRVQSHLGVTNLIIQNNRLISLGRNSTIKTFFIDKSGLSLVTSDKVPYSWLLDIVDDLVIAFSGNNFVVWNYKTKRLVSETVCGGGHRSWDFSKTDAITFLYIKDKFVNKLQYNLKVNRSHDIIESFHLNEVNSMQIINTNFQYILISGGEDTTIRITVTDEQLSSFVNKITLKSHLSSIRCITTLQLEPKRHLLFSAGGRAQIVSWTLTYSLENSTIHDIMCKENDSYYEIIDNEESETRIMDLCAMTFMEQNFLFAACSDGYIKCFSISDSFKLTLYRNVFYKLKCIFKIITIKALCCDVLVTMASDGCVVFWQTEDFLSGVEDVAPFGSLSVHDSGINTVSMLRLAADSFLFLTAGDDNIVVLSYLKFNGNKEVGLNVEIVDQYQKHGVHWAQITGTFINDKFFMTASVDQRILLYTWQLKDEHVECKLLTKYNTSVPDLKGLICFDDDDKKFDVFIYGLGVEFLKLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GX81</accession>
    <name>A0A6P7GX81_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein dispatched</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114344027</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150677.1">
        <property type="nucleotide sequence ID" value="XM_028294876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GX81"/>
    <dbReference type="FunCoup" id="A0A6P7GX81">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663653.1">
        <property type="protein sequence ID" value="XP_050519610.1"/>
        <property type="gene ID" value="LOC126893448"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GX81"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="836"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="379"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028150677.1"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118891" checksum="808140FCBA8E86A3" modified="2020-12-02" version="1">MFIIRWLIFVIVYHPKFLVTFIGLISTTCLSLTLFLKSIPDFKEPQLGFSTRGTSIANRLVAWQNIIKSIDPAGPYTQNPKEYRLMKLREQQTIDRSVRPLNSSNYTRKSGTNHRGKKVIYGKEVKLPSKNDTNWIDMEKWRILKSKHVKSAKKLAQLKDDFFCGNPDSQYAKLVIAAEDGHDLFNAEDLITLCYFQKKLTKIKHYKELCVQDNNKKPCIPWSLTNYVAYFSLKSSCNKIKEKDVEFVKNYLANCSKYFHSSELATGSDEVPLECRLYDSVFNVFNYINPITFLPENGTSNDTEVTHSMVFLPLASSTAIMPYYRELIKTDLTYNGLKIVAMDMGLKDALFDEYLVWDLYLVLGGALFVFCCIWFYTESLILTLVSAVIIFMTLNIAYFVYAVVLDINFFPFMNLLTVIVVLGIGSDDAFILCKIWNLQKMANRDNEASLELMMSITFKHALVTLFVTTLTTAVAFLGSYASYVTAVGCFSLFTGVAVIINFILMITWFPAFVVLYEGSRFSKSSYTTFLFKKVFRRSMVNRCKLNPKDYITVQENVLTESIIQHRYIWFSLLFILMIAGLIVLFVYPKIEFPNSSEFQLFKRSHPFEQYDFVYKTQYWFVTKEMMEYRMPMRFVFGVKAEDNGRSLDPTDLGTLEEDSKFDITAASIQIWFVEFCRELRSQNFYHLTQGPLLLNCFLETFLNSMDIKCEDGFSGKNRTPCCNASKFPFGRDVFDKCILEEIADIYKTPNVFAGTFSAGPIFSKEQNTTIKVAVVEYDSNFIYSMSFDDMNHFYQEVTDWMTNKMESAPKAIQDGWFISDLGFYDLQRELRRSTEVAVGISLVLALVVLFCSTRSVLISLYSIFAISSAIIVTMACLVLLGWQLNVLESTALSTAIGLTVDFSLHYAINYRRCPKDVSSDRKAATRYALNHMAGPSFMAAITTGSAGAFMIPSIVLPYVQMGIFLALVMVVSWIYSTCMLGSMLAIVGPVEHCCKRNSFGANRHAEIVLPEPLCLSREEFFDESYSHELDSLATSTRQDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GXB9</accession>
    <name>A0A6P7GXB9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Homeotic protein female sterile-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114341830</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148470.1">
        <property type="nucleotide sequence ID" value="XM_028292669.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028148535.1">
        <property type="nucleotide sequence ID" value="XM_028292734.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508203.1">
        <property type="nucleotide sequence ID" value="XM_050652246.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508204.1">
        <property type="nucleotide sequence ID" value="XM_050652247.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292669.2">
        <property type="protein sequence ID" value="XP_028148470.1"/>
        <property type="gene ID" value="LOC114341830"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292734.2">
        <property type="protein sequence ID" value="XP_028148535.1"/>
        <property type="gene ID" value="LOC114341830"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652246.1">
        <property type="protein sequence ID" value="XP_050508203.1"/>
        <property type="gene ID" value="LOC114341830"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652247.1">
        <property type="protein sequence ID" value="XP_050508204.1"/>
        <property type="gene ID" value="LOC114341830"/>
    </dbReference>
    <dbReference type="GeneID" id="114341830"/>
    <dbReference type="KEGG" id="dvv:114341830"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="359"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="681"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028148470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028148535.1"/>
        </source>
    </evidence>
    <sequence length="1392" mass="150317" checksum="6DF341D7F90E1C36" modified="2020-12-02" version="1">MERPPRNEPTVDPVNGVVQPLVQPPPESPGRVTNQLQFLQKTVLKAVWKHQFAWPFQQPVDARKLNLPDYHRIIKQPMDLGTIKKRLDNNYYWSGKECIQDFNTMFTNCYVYNKPGEDVVVMAQTLEKVFLTKVADMPKEEFVVESPGKAGAAKGKKGRTSTAGAVSAPPTPTTATAGSGGRGRPPATVSSTSATPVATTTGSSGLPLGTQAPATVPGSTATTTIAAASTNNSSLSNQQLNSSSSSIHGSGSSLGNSLDSSSVMPANVIPPAQPAKVKKGVKRKADTTTPATAYDYPPTLESKSAKISTRRESGRQIKKPTRPELDGHPPQPPPLKPKEKLPESLKACNEILLELFSKKHSSYAWPFYQPVDAELLGLHDYHDIIKKPMDFSTVKNKMENREYRTPQDFAADVRLIFSNCYKYNPSDHDVVAMARKLQDVFEVKYAKIPDEPVNRVGAPAVNNIPAKSETSTSGSSSDSSSDTEDSEEERRNKQLKLLEKELTAMQEKMRKLVDESSKKKKEKKKDKVKKKPTSGGSLANASLSTLPNSSSAGLGKPGAGGHGALNKSNNNNSIAADSVDDSIASVVSGADLKMAESHHPQTGTGAHHPPAGKSLNMHHNMTANAGANASAQAKTPKSKGLRGNKPAAATNAAPNKRVKANNKAGAGRKKNAAQPPPMQFDSEDEDNAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKPRKPYYKKVAGKSKDEQIAEKKQELEKRLIDVNDKIGNSKKAPKKDEANKVDPTGAGGPSGRLSSSSSSSDSDSSSSSLSSSSSDSSDSEAGGTANRQAKKKANKKSPNPSLGSSTTTTTIKVPPPQTTATPAPPSQAAPAITTAATANLTTTVTVPPLTTTTTNTIAPPIQPAPVPNVAVPAQTTPAAPAFTPSITIKPSLQAAPIAPTVPPLIKSIEKLPVTTLLPPTVPTITPPTVPQAPKSVALPTPSPDKPKPNIISPIGTFTDPIEQSLASLEHDIKQNDPMDVITASTMMQMPTTLTNPIVSHPHPNLNLNPTINHPILQPSTLSMDLKAPIMGTMAPSNTMLHHGLQQAMETDISIPPPPTNMLHGQNNGFGMKHNFDLTTNNNGLSSMGLPMEMSISSMFDPIPQNINPMMKNDSQLKMDDRMDTLGGLLNDKKSNLLIQKPMSQSFGFKNDKPDHNVKNASSWSSLAKGKSPQNNIPGGSSKQQVMDSFKAFQNKAKEKADREKQRLENLEMKRQQREQAERERLRAENERRREREEEDALEKARKAVAEQQQPIASQRVEELRSSPGEGSTSPGSLSSGSERISERERQRLQEQERRRREVMANKIDMNMQSDLMAAFEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H075</accession>
    <name>A0A6P7H075_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114342825</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028149435.1">
        <property type="nucleotide sequence ID" value="XM_028293634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H075"/>
    <dbReference type="FunCoup" id="A0A6P7H075">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293634.2">
        <property type="protein sequence ID" value="XP_028149435.1"/>
        <property type="gene ID" value="LOC114342825"/>
    </dbReference>
    <dbReference type="GeneID" id="114342825"/>
    <dbReference type="KEGG" id="dvv:114342825"/>
    <dbReference type="CTD" id="387787"/>
    <dbReference type="InParanoid" id="A0A6P7H075"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028149435.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26428" checksum="7284586FFD4F3D25" modified="2020-12-02" version="1">MGRQLVKLLKVGKIKYGCGLHLQQHFVQLHKTTTENQNTLIIVEHPHVYTTGIRDKNYSQSEEENLKHKGAEFYRTNRGGLITYHGPGQLVAYPILNLHNFNPRIHWYIDKIEKTILNLCKKFKLEAELLGDRGVWIKDKKICSVGLHGSRYITSHGFALNCNPDLSWFDHIVPCGIEGKGVTSLSQELGREVTVAETIPVLLESFKEIFEVDLIDYPEEEADCLQKTFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H400</accession>
    <name>A0A6P7H400_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apolipoprotein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114344084</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150735.1">
        <property type="nucleotide sequence ID" value="XM_028294934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H400"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294934.2">
        <property type="protein sequence ID" value="XP_028150735.1"/>
        <property type="gene ID" value="LOC114344084"/>
    </dbReference>
    <dbReference type="GeneID" id="114344084"/>
    <dbReference type="KEGG" id="dvv:114344084"/>
    <dbReference type="InParanoid" id="A0A6P7H400"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028557478" evidence="2">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028150735.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21676" checksum="EF8BBFCC90B0AE32" modified="2020-12-02" version="1">MIIFAVIFCSVVIYAQAQVPVTKCPTVKVVKGFDQEQLLGDWYEQARYPSTLEDHARCVYTNYYKSSSTTAAPEPTDAPADNSILSTTEFINSDTNEWTILEGNATADPSEPAKFNVTFTDLKLTVPYWILGTDYSGFFVGYSCSVIKNVTGVSLFVLTRSFEPVQSAIDDAIAVIKANKLSTAELRQTDQDVCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H9Z2</accession>
    <name>A0A6P7H9Z2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC114349332 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114349332</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155472.1">
        <property type="nucleotide sequence ID" value="XM_028299671.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504045.1">
        <property type="nucleotide sequence ID" value="XM_050648088.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7H9Z2">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299671.2">
        <property type="protein sequence ID" value="XP_028155472.1"/>
        <property type="gene ID" value="LOC114349332"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648088.1">
        <property type="protein sequence ID" value="XP_050504045.1"/>
        <property type="gene ID" value="LOC114349332"/>
    </dbReference>
    <dbReference type="GeneID" id="114349332"/>
    <dbReference type="KEGG" id="dvv:114349332"/>
    <dbReference type="InParanoid" id="A0A6P7H9Z2"/>
    <dbReference type="OrthoDB" id="6257037at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21227">
        <property type="entry name" value="Myb_DNA-binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1335"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1242"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1268"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1281"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1335"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1348"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1415"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028155472.1"/>
        </source>
    </evidence>
    <sequence length="1513" mass="172231" checksum="B024A8BA06F1FA3D" modified="2020-12-02" version="1">MSDNESCNKDESEENSDDNLHIAIESPSRKRKPSPVPTESERKIIEYIEDELEHKLEEKAAKSNLNVINVKNIIKHVLTSEDVLNLIKDAEGSKSGENISPLFELKWTRSKVKELSSASGLPLPPVNLTAPKPASEVQVLFTEELQEDSSGDEYIPGMGDEDKDDMEESEDDPDNSLFSDPPSIEPETPPEQHVASPPPPPQPNTDADTHWTEDGVFKIPSAPKDKEEPTDETTIAKRTRSKLSLSSTPLEVIEEAFIPPDIPPDLYEMHCDNEDWRDFLKTFTRPLEEVEKVPEEEELDPEYNVLSDEEIDKPDKEELREELRVDRAVKVSKKELNALIAELYEFCSNEQAHLDGIEEDDFDPTSFLETQLVEDNSKKTDTLVSNADESAFQTKTDDARLYTDMQINLLEQQMRQHVQLLTQNFILTYEHPEIHQHAKQMKEYLLNLKYLAGDNEESKFCAVNLEEALDLVSSWEELVASNTDDVKRMKSHVESTMNKSLACTQKGIEYIVTFPSLILETISSSCVFLYPSLLPKIPFKSPRCFHSKVFTNPELQLVSIGLEQFLPFATQELGSGKVAKKKLHEYLSYFIHEYVLPIKSPRQIERLISRCEYTRCGANPIKYFFTFKKAPSYVQFYIPLEALKILPPCQRKPEELPYQWKKFCFPSHDKDNRTPNPLPTQINSIGLQNITKNPLSTQINSFWLQPVSQPISNTQQLILPKGAISLGNSNSQLILSNNTQQQLILPKGVTTSTPLSVVQRKKPLRKRSRRQSLFQSRLDKVKQDPISKFVRILCEPSPINKILRLFSSVSRSHTSEDTTTDEEISPPPKKSNLLSPGVSPNTSFKENISLPVTDTHNMLPNMPSLSSVIKINSLNEDTGNEGKNTNSSKHNISLEISEEGVSDFQSISEHSEENKMDKDNSDGSNILTATPSTTKTSITKKELSGAEKKRAKMKREFLANLAISTPEDYEVEQEKHKMFALAYYDKLRETLDLQTYHKMTQILCDYEKDDALELYYKVEAVLSVKYKELADEFLLFLQEKEAAAAGRLIPWIQMNNRSKFLRKVETFFKDQPAQLRKIYQSLTELSHTVGVTKEKMKSSLVPMFKGNTFLTDLFLQNFMDEPPPPSLMEGPYEVIDVNKELATNDDEEPFETITVPDVEDKYGGITCICSCHEIEDVEFKSRIRHCSRCGTKFLNGRVYIQTGRGLRPAAVSFLNSSNTDHSSRLSEKSSHSFIRRKKRSDTSPSKQVSQSSVKDNPDEETDEDGEKKKKPKRKPRSKKPKLSDDNKDVTKKATPSKVRNLSKEFKSTPRKRTYLKKMNTTLKVEPMKIGIEEQEHIETELDEHVETEQEEQVETELEEQVDTYTDDKTYIKPGTSNGQQKRLHDESCEEGDQSAAGESSGEVKLGSPEQQTADSESEFCEESSQDNCESDSNSSTSSIINTPQSYADVLSHNSSWKREEDKIILEGFQTENDKDRAFKAIANQLRNRTVDEIKARFDTLMDLLMKTVEDHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HAS2</accession>
    <name>A0A6P7HAS2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114346398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114346398</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152950.1">
        <property type="nucleotide sequence ID" value="XM_028297149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HAS2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648236.1">
        <property type="protein sequence ID" value="XP_050504193.1"/>
        <property type="gene ID" value="LOC126883047"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HAS2"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028177048" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028152950.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22034" checksum="B70562DEB6A0230B" modified="2020-12-02" version="1">MFKVTSLVLIISILAPFAIAGQDSAVEWRPYNGVPDDHAIIIQVQTEYSPAVYIGLAHVIDNAAQSEAYLPVNIVEGFNYANVTLNDKNYMADNLQILCFKNPDALGWQYTKAANFDDLLNDSKIAPIVAGWEAHSVVYNATVYMGVGYIPALGGNNVGKVYHGLPQTQNRRDGSLYIDRSGVSAEYYLAGGSFNVPVYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IB55</accession>
    <name>A0ABM5IB55_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129007.2">
        <property type="nucleotide sequence ID" value="XM_028273206.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273206.2">
        <property type="protein sequence ID" value="XP_028129007.2"/>
        <property type="gene ID" value="LOC114325206"/>
    </dbReference>
    <dbReference type="GeneID" id="114325206"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129007.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="358" mass="38932" checksum="1FF5E64C6BA6AADB" modified="2025-10-08" version="1">MAPTKDNLSAVLYGINDLRLEQRPIPVPKDNQVLLQMEVVGICGSDVHYLVSGRCGPFVVKDPMVIGHEASGTVVQVGKNVKNLKPGDRVAIEPGVPCRTCHHCKTGAYHLCPDIFFCATPPDDGNLSRYYVHDADFCWKLPDNMDLEEGALMEPLSVGVHACKRAEIKVGDVCLITGAGPIGLVTLLSAKAMGASKVVITDILDVKLEMAKQLGADYTIKIEKGMSEEDIVKRVIQLLGQEPNKSMDCTGVEQCVRVCVSATGVNGCVVLVGLGKIEMTLPLTNALIKEVDVRGTFRYVNDYPTSIELVRSGRVNVKPLVTHHYKLEDSVKAFHTAKTQEGNPVKILIHANPNWKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IBX7</accession>
    <name>A0ABM5IBX7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129467.2">
        <property type="nucleotide sequence ID" value="XM_028273666.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273666.2">
        <property type="protein sequence ID" value="XP_028129467.2"/>
        <property type="gene ID" value="LOC114325572"/>
    </dbReference>
    <dbReference type="GeneID" id="114325572"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 14" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129467.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="632" mass="71308" checksum="DEAB33CE84308D7B" modified="2025-10-08" version="1">MHKDTFKMTEDKPIGLENPAFDRGPADLENDLKPEQSSNTQPLKAVERSQWGNGNEFLMSCIAMSIGLGNIWRFPFIANKNGGGAFLIPYLITLTVIGRPMYYLEMILGQFSSRGSIKMYSKLSPVLKGIGYGQILGTFFCASYYAVITAITLVYFFNSFTSNFPWATCQDRWQEYLYSRNITCVDQHSNGTDTGNGTITSSEMYFRRDVLDETDDISNGIGLPNWRLALLLFFTWTVTFLVSVKGVRSSGKASYFLAIFPYVIMIILFIRSVTLDGAVDGMLYFIKADFSKLLQAEVWYAAVTQCFFSLGVSFGQIITFSSYNRFDHDINRDAFIITTLDTFTSLLSGFTIFGILGNLAHELNVPPSEVISKGGGTGLAFVSYPDAISKFNFVPWAFSITFFFMLFVLGIGTLVAAHATVITSIKDAFISIPDWIIASVTAFALFSLGLIYTTSGGQYVLDLVDNFGGTFVVFICAILETLAITFLYGINNLCIDVEFMTKRKVGIYWRITWGLAMPIFLIAIFIYFVGTLKPMEYGIYSLSYPLGLTVMGWSLVGLVVLQMISWLMYYLYKHKNFPIKQMISNTFSTSTWEPDDPKVKEDWKKYRQDAAITNTLKRRSWFRRKLKTITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICM4</accession>
    <name>A0ABM5ICM4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129907.2">
        <property type="nucleotide sequence ID" value="XM_028274106.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274106.2">
        <property type="protein sequence ID" value="XP_028129907.2"/>
        <property type="gene ID" value="LOC114325950"/>
    </dbReference>
    <dbReference type="GeneID" id="114325950"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="9">
        <location>
            <begin position="503"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129907.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="649" mass="73990" checksum="24FD46B38AD30584" modified="2025-10-08" version="1">MTFVTDDRNKKQNVKVVKLKYFSDKQKECNFMSHLKKFTMGTIKNVIVVFLTVQIFIVRCSDITKLAFGQFTHGLPAAFGDFNSDELTDVFVLTNREQTLQILLAYAEEPLLRPAPTLNCTFKNHKITSVVPGDFDGDALMDVLITTIKADTSINNARTSIYILWGGNTTFNCTEIEGSPLIEMLGQPLAIDYNQDMIIDLFGEDIEEKRAFWVFGKNRTEPKKVEMHHHNKEPNGVLMKPHAHAFLDLNDDYMADLFITTKDNFEIWLGREESNPKKPKFSYKSTIPHPINPKTSETAKVIGQSLFVDVELKGKVDLLTPICYDWKCQNGALLLYSNTEEKWIDLQVNFKDDYQSVWTFFKNENYKYNDVITLRSGDFNMDGYPDILATLTPVSNYNAPQSFLLENVPCQNYCGSLKRTFEVRWSSLNPFKNGTIMAAFFDFYQDGILDCIVVQSVNGEYKTAAFKNSLDYDANFIKVMVLTGLTNKNNPMMMGRVGKKRRTYGTNLPGPSISYKTTTQEGNIRHGLSCQLPQSAHFSLSLPYTIFGLGRTPNFVDKVTVGLSNYSKDWTQIIPNSQMVVIPWPTTEPYKWKAQLFVTPSKLILMSVAALTTVCGLITVIIGVLHWKERQEDKKERLSESHRFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDW0</accession>
    <name>A0ABM5IDW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ALMS motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130668.2">
        <property type="nucleotide sequence ID" value="XM_028274867.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274867.2">
        <property type="protein sequence ID" value="XP_028130668.2"/>
        <property type="gene ID" value="LOC114326479"/>
    </dbReference>
    <dbReference type="GeneID" id="114326479"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029299">
        <property type="entry name" value="ALMS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15309">
        <property type="entry name" value="ALMS_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALMS motif" evidence="6">
        <location>
            <begin position="2110"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1089"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2135"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130668.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2234" mass="248088" checksum="0199DCA741E80E29" modified="2025-10-08" version="1">MEKNDKEKSEGEDSSTKQVLEYYQKYSQSKQLPKYFSGTSISYLPQIVDDEPSARKRDIIYPTRDVTTIPPKQYEKPEPNPEMLSPTESVASNKKLEWDNLGDIGYNNAKRLHKTASLPILTQHPIIKIDDIPKSPTDNVKIVIYPYTSSSEDKTSEKNTVQSSSSSPFMEKEIPSSSGTTSFHSSEKQKLLSSDSDSSLNNSKILEFKKSLNYIKKKIGLPDAHSTPHETGSPNIECQVINETPLVKKTDKPIKNILRDIQIENENVKSNMLMKPTNSGITFPANSNKKNVNLCLTKPILVDCLPKTNKKQYAVGVQTGSSVVDCKSPPEPIELITFYKEPDNNKTSDSGKSSSSNGVASKCDSFEYVKSSNNGQNISMRSESNPIEIAEGHITDNNKENSNNSENSEAATNNQELETHCTKSDDIEKHIYVLQRLIRSKKYDSSAKRKYIRKILQKITESKYLEDSSTSSDLFYPKTDPSKILHDQIKNSSFKNENTSSSYQSHEDKKVSPKKKASESTDSDISHEREQKIEIKPSTSKSATFGYRKESKLAPKKKLDSTNLLSKPSIQSEVPVSKRTKRTPFTVTREPNDTDKSSSPQSHQNWKECKTVSEKMFENSRQVIGAGDQVTQFADKERQYQLNWIDREINHLGKLKSILEKHKEPYPLPENLKKMTHVYMVTADNNDAVHRNYVIETKLGTGTSRQRNFRINGENYIVEDPNVHSQDNNQAPPLVADIQVLATDKTTNIKVTAFCSVCKRSPCVCVTDFLQGISNPFKVSDNKVQKHLNDKAKSYSSTCSCNTTASSTATSRDSSHTICIHCHRAPCTCCSCKKTHDVKTCSVCQLYSCMCVISPKDSYVGTFIPTKKSSEGSQKKVCSLCKALSCMCSVETKSRKCSTCTTYPCICKKISTKTKKSECKCKSTPCTCSGLSFKSAKTVCSKCGISSCICPLSSRTTSSTTSTVDTDLLRKLFSDCKCGASSSCSCEFVNKLLQHFNKKDVEVYTRALSNECTDVGTQNLVPVDDKRVQDVLLTQEKYVQPKFTKTDCSSQTDTLKSHSKVVSTEGAECINELVQAGIRDESTGTIHSAATTTETVAPLGRTSSLDSRKSSIGSDANRHISIQSDVCSKEKATYSHDLPERVDKSVGKTTDECGTQSIKISRKSFTESDTNKHISIQSDVCSKEKATYSKDPPETVSKSVGKSTEECSTQHERKKGYFAKLTERGVSGSNNNIESVDKDIEARVSQVLKGTDTCTPRETADKGVCHKPSLVDQETDYSPRIVSVEQGTCPRSAESSARVSIDTGTCHSPVVDKEFQTTAKTLVDQGTGDQKASDQCHKSLNAQHTPPMFYETDVGVSTVSEKHRRGATSTGGSKKSRSRSSESKEIGNSGFNTSSGKKSKVPHSEKTTVTSSEAEVGPSLKHQKISDDISTSTNKLKVSSYEQTTIASSEAKVGPSTTHRRLSDKIGTDTVNLKASSGEQTVLTSPDAKVGPNVTLRKTSDDISASTEKLKASSCEQTTFTSSDARVGPVLTQGGDICTSTDKFTSSDAKVGPIRGQSGDICTSTDNLKVSSCEQTIFASSDAQVGPSLRRSDDICTSTDKLQVSSCEQTIFASSDAQVGPTVRRSDDICTSTDKFSSSDAKVGPIRGQSGDMCTSTDNLKVSSCEQAIFASSDAQVGPSLRRSDDICTSTDKLQVSSCEQTISISSEAKVGPSLRHSDDICTSTDKLKVSSREQTTRVKSKKRREIDIDSLKKNLNSRGIQTELLSNDIRSIDSFACICPSQSSIEKSPCYCCGDKRKKKSKHMLICAPSEDSHKSRKVKTYYIKEASLKKSGRRRCYSSCAERVCCRTRSKSVLKESCCSCHCESKKPRCCCQNEKLNNCTEACSAATPQKTPISTDDSPTDSVYTNSSAHSTCCCCGNKVPLEQISLLRSNNKQFSVCEVCLKKRPILTTICFANPEDTTTESSTPSKTVTDHFRRAENYCTCKKSVKTKNFEYCQHCRQQLKKTQKNRNGIAYTLTLEDETPEKFKSRSKKKIKKLEEIKIKVPNPFNRKQHKNRENNYRKDEDKMKRLESAEDSENIDIMNNGNYSSDEVCKTMNNGKENKQCYSLQEYLQKNRPHFVDAAEYRRLALINNKIERELNKDDQKLKFLEENANNNRLKRQKLFTEQEMREITKRNYKKLPEVQQKLTNQRKEKLRSADRFMADTLNRKIQNFVLKGKRSFPIDTNVVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEM1</accession>
    <name>A0ABM5IEM1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131161.2">
        <property type="nucleotide sequence ID" value="XM_028275360.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275360.2">
        <property type="protein sequence ID" value="XP_028131161.2"/>
        <property type="gene ID" value="LOC114326902"/>
    </dbReference>
    <dbReference type="GeneID" id="114326902"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131161.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1127" mass="128577" checksum="4014A3E024D23E56" modified="2025-10-08" version="1">MNDNIISELEKAAEIIMAPPNVISNEQRRLAESIFLDFRKSKSPYGLCRDILEKSQNPYVLFEAAEVLKVAIIREWSFLFENDKTSLRQYLFEYITTRNLPPFVRDRLLQVIAIMVKRASIDDGGRERANILKQVESLIVNAEPAKKILGCNIISNLMQEYASTVKSTDVGLTWEVHFKAKKQFEATDLKRIFQFCIYLLSEVVKNDPPYSDTLLELSRHLLKITEGVLTWAYVSSILPKKIVGIYESIYEALKLNDSWSEIVLNPDFLPLMFQIYWKVRDIDQLAHHSLICLVQLASLSGGILPNDEIRLKYLHSYLVSFFNLISNVTIKNKEALGLSNIVKKLITFFLPCIFQLPDGMKDTLLDEFTRITCHLCDGAVMEEIENEEDRYFTDAFDNMLEAWTGLIQDLSHSHYDDKFQDCAKQVFNKYVQCHLAPPDGCRRSNVDVDDDNEDNDRVRYKDQLQVIGMFGRVVPGHSLQLLYKLLEDRITKFSYHILSMQKGAMNLNQHAGLTDLFEDIHWVTLISGHVICMDSDGETPMIPSAIMKYSIDQHRGQQSTLQASMAAIEALETKFSQPENLEQCDHVIRILFDVMNLCALEDYAASAKLKHLMSPEVGSTAMWFLKRWCLSYLLPVENYYEELSPTLIGCLGKDTQGARLVVSYVLSKIQSNLFHFQSEPILLRDTVELFCDIVCVKQKSSHIVRTESMRNLIKLFGSLEPGSLPPNIIRGLCKGFVLAGVALDTRNDSIHNAMNEYYDLILTPLQQRFKAVWGQENFTRIYQEERIQKIVIDLLEAFIGIAKGSLMPSSTTLFHFLAPILSELPALITVYHNYQVIVQLVLELFGQCAKYMLCYLTPFDSKRLYESSLATVQAYAKCNQGRFTTETFAEESSFQDLALILDLLTFILSKDCVDLCTETDNEEISVVASDVSLFGLNFIMPLMTRDLLNYPSLCAQYYRLLVLINDIYPEKICNLPPELLNTLLRSIELGLTNFGSDIVQASLDFIQAMATYICTKKLVQQPYAQAIRPFLKLVIDLTLSHQINNDTVCSASTCIYALMCCFQDDYKMLVQSLIQTQSDPTTADRLTAAFNNLVLNVDMSGNRLPKLKFRDNFDKFLANVHGFLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJ94</accession>
    <name>A0ABM5IJ94_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134103.2">
        <property type="nucleotide sequence ID" value="XM_028278302.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278302.2">
        <property type="protein sequence ID" value="XP_028134103.2"/>
        <property type="gene ID" value="LOC114329264"/>
    </dbReference>
    <dbReference type="GeneID" id="114329264"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134103.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="305" mass="35855" checksum="D53952A5ABAA3FCE" modified="2025-10-08" version="1">MSNKNVKNRKTKINIFESFLESYQYANPNYMKQVKTTLKYCESQVTIASYFVDAKDFEGGDLAFFDGASGLLKGILSINNVKREALMKFNRYNNRYIQNEAAVLAQLKHANVIELLGYIASTKKDNVKKIFLEYMNLHDLARGLEDKEVDLSIENVKKIFIDLATGMEYVHSKKILHRDLRLSHFLYNNKNEYKIGGFDRAVYVGNSNGEYQSPVWESMLRVTKTLTPPEWDEMEKYTYTYKTDVYCMGYCFRIILRKRYPPLEAQLEDIAKELEEFVFDNMFFEIPQCRKDFTKIKTFIQNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKM9</accession>
    <name>A0ABM5IKM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Proton channel OtopLc</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135011.2">
        <property type="nucleotide sequence ID" value="XM_028279210.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135012.2">
        <property type="nucleotide sequence ID" value="XM_028279211.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279210.2">
        <property type="protein sequence ID" value="XP_028135011.2"/>
        <property type="gene ID" value="LOC114329935"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279211.2">
        <property type="protein sequence ID" value="XP_028135012.2"/>
        <property type="gene ID" value="LOC114329935"/>
    </dbReference>
    <dbReference type="GeneID" id="114329935"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF62">
        <property type="entry name" value="OTOPETRIN-LIKE A, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135012.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="111071" checksum="FAD6EA824EEE895F" modified="2025-10-08" version="1">MQRCPYLYEMKERLLEDTIPMKIIMPKEVPPPCPPLPKDQQPLIIQQKPVATIVKIDNAGYTHTTPMHCTAEQTPLVPEKQESKFFPICQKIFPKNAKTSLFIVTSFVYAKLLVVICIAYVISHIVTHNIPLYYYEGFFTYLYGLSILFLLYVFCFLLQESSCCSGNEKQPKPVPKKNGKEKDVKIKKEKEKEEKDKKKKEAEAQKKQKKKEKDKKDKKQEKPEESNQPISVQWQFDASTYRRNSEGVVDAGLAAVPVPVEEITQSQAATVVSQEQPPAAPAAPAATGGSATQPASRQSTPAADAEAGESNSDSKSKCKRKTSQNDHSHGSFFLRIGAIAFGLGTMIYIGLEFGGFFEIPFNSPCYMILRGVNPTLQMIFTFMQMYFIFMNSRLNIHRFKVIARFGLMHIVATNICVWIRTFFIEYLKDITKYHVKYFNATNSSGEASLGESIKAHNLRNANTVLGTHRAVPDKILETTTSLPITTTITSLFSRFITTLRPVPRNPNPWAFPSPTPEKHIPANLWKMMPTTPSTTTTTTTTTPFPTTPRYFGRTTVARVWRAITTSFTSTTTTTTTTPSTTTLFTTTSTTTPSTTVRSTFTTAASTTMPTTTVSSTFSFQNFFDSSLVRSITADNINSASEDKTVDLFPEISNTVANNETEFLNDIIPQAFSFTSSYNRTSNNSDYCGRLNIMGTIVEDAGPYLYPFIIEFSLIGAAVIFVMWKHIGKNPKYVNQENLEHRLEIMLSRRAVALAQAQQHGRVDCVGASKGLFFGLLMLVGSLICLILFFVLVSNNTFRVLAVYLAEVSHCALLVLSIIAILIGFIRVKSLKFKKEEQSDLNDILLRVSAFGLFLYAVFSVIAGHLNAFSQEANLLAMVTGILVVLQVILQLLFIADVSRRRVHLPEHDRSKPGRQVVTFLLICNITIWIIYTFEMKKVEENPVQLKYYGYLTWAMVQRLTLPLCIFHRFHSAVALAEIWKTSYKPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKQ0</accession>
    <name>A0ABM5IKQ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ecdysoneless</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135079.2">
        <property type="nucleotide sequence ID" value="XM_028279278.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279278.2">
        <property type="protein sequence ID" value="XP_028135079.2"/>
        <property type="gene ID" value="LOC114329982"/>
    </dbReference>
    <dbReference type="GeneID" id="114329982"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135079.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72584" checksum="1579567ADD776930" modified="2025-10-08" version="1">MAGMTNVLETVREDDFVEYFIFPQIETHDEQEQENILTALLDKTNKIIHKYTKNFLWHKDDFKLVIRTSTSNFLNEIEGQKEALPPHLYGVSHYGDNIEDEWFMVFLLRQLTKELTGSIARVHDIDGEFLLIEAAEYLPNWARPETCESRVYMYNGNIHLIPHDDSTSTTITINEAVSSIRENPTSTVASTEIQQAIKTKLDGYPDKLKDNIHNAVVYIPIGVAKALKAKPNLISAAVQVFCNRDSVDLKACRAMKYFPPENRVKQRVTFTKCLYAMLTHSKYLPDRRTGWNLPPTNSKEYQSNILGVKLACGFEILASQAKPSTDVESDRGWQNYLKSLKEKGYFKDYLEHSLGYNNLLNKAKEYYVDHRDSMHQNSSIGQEILDLSRNIDIEVEEETNLVDDDDSWLNISPDDLDKMLQEKYGQKKIFNVNNNTDASSFTEKLNSFLNHVSDVDGAEFPNENESPVRPPRRKNKSKVSFSSEAKTEETTSNNKINFDPNSFTCALQNILNFSIPEDDSWDLDSDSEMSEYEEDNYVKDQSYETAKDKNKLQKYMEEMDRELEGTTIGQSFEKKNGDNFEDIENFKPVDINVNALKYILESYKSQLGDAGPSSNMLGPMGLHLDPKDNIDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKQ6</accession>
    <name>A0ABM5IKQ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription termination factor 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135075.2">
        <property type="nucleotide sequence ID" value="XM_028279274.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279274.2">
        <property type="protein sequence ID" value="XP_028135075.2"/>
        <property type="gene ID" value="LOC114329980"/>
    </dbReference>
    <dbReference type="GeneID" id="114329980"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135075.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38924" checksum="4A3CFC02D2BCEB58" modified="2025-10-08" version="1">MFGNTIKLNLIRSLRSFSVVAEDSLVNATVLSTSAPANKNSELTKIQKAKPRIVDLAEVSKVLRPGALSSMYINKSEILQQLVKLKVKLYEIEKDPEATKFILSQRFEDIKDKIIFLKELGLEIEDIGNTITKNPLILKENIEDLQVRLNYLQYKKFTSEMILRIVSANPHWLSHSTQDIDNKLGFFQSNFSLTGNEVRLLATKSPKLITYPLEKVKLAHFVLKEEMGFKAAEIKKMVLDRPQLLKSAQDKLLSTFEYLHNTMKIPLEIITIFPEVLNCRVKRLKERHLFLARLKRDLYNPKEPNYVALKTLVSGTDSYFCTEVAQSSVQVYNEFLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPW6</accession>
    <name>A0ABM5IPW6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">27 kDa hemolymph protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138432.2">
        <property type="nucleotide sequence ID" value="XM_028282631.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282631.2">
        <property type="protein sequence ID" value="XP_028138432.2"/>
        <property type="gene ID" value="LOC114332852"/>
    </dbReference>
    <dbReference type="GeneID" id="114332852"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997:SF2">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045351120" description="27 kDa hemolymph protein-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138432.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31281" checksum="2BA7FBD02E6C4D40" modified="2025-10-08" version="1">MKLLGKVLVTLLIGCAYTLNLNKREDFGNLNQPGVHFGNSGTSSFGGRGNNPFGSVGNSQANANFMQAQSMLAQLSAMIKQKCEQTGHSDVFQTFQAQFEQTTKCMEGKINLNGNVVGEDFSNAARTNQLPNFFKKYCKLWPDVHGCTQPIVTSIEKCLNSDEKRAVEESVSLLDDTNNFFCENNADRSIRLLNGNIVQCLQTVGREIQECATNLAQKRQTHQSGRKSLFPYDEEDCSDFKTGRQCINSKLTKCESKDPSKIFDDYFAMVQGKVCRSASSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGX2</accession>
    <name>A0ABM5JGX2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497190.1">
        <property type="nucleotide sequence ID" value="XM_050641233.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641233.1">
        <property type="protein sequence ID" value="XP_050497190.1"/>
        <property type="gene ID" value="LOC126878480"/>
    </dbReference>
    <dbReference type="GeneID" id="126878480"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="192" mass="22268" checksum="28339F7D807F3EF1" modified="2025-10-08" version="1">MNASVFENWFSNILQKLPKNAVVVMDNAAYHSRKLEKIPTTSSKKKDMQEWLKIKNIPFNLEMVRSELLHLIRLNKNEYNMYVTDEMAKKNGQIVLRLPPYHCELNPIEKIWAQVKNEVALKNTTYKLKEVKNLLLQALDNVTPTHWQNCVKHILKVEEKMCKLDGIMDSVIEPLIISIGNDDSDTSSSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHB4</accession>
    <name>A0ABM5JHB4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="21">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="21"/>
    <dbReference type="RefSeq" id="XP_050497330.1">
        <property type="nucleotide sequence ID" value="XM_050641373.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641373.1">
        <property type="protein sequence ID" value="XP_050497330.1"/>
        <property type="gene ID" value="LOC114341705"/>
    </dbReference>
    <dbReference type="GeneID" id="114341705"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 21" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="26">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="533"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="650"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="839"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="996"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1029"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1364" mass="155189" checksum="DC169F3A3C803CAB" modified="2025-10-08" version="1">MAVNGLACTAQFRRDSGWRISGCRYVKTLLLYTLLLSTTFPGFLSPAKADFEPIPLSDSINENDAKRICASMDIKNSLESFKKLKDCEVIEGFLSILLFDNVNETELSKMSFPRLTEITDYLLLYRVIGLRSVGQLFPNLAVIRGQQTFFDRAFVIFEIPTLQEIGLHSLTDISRGQVHIDKNPSLCFVHTIDWDRIIKDKNKDNSSKILLNSLKPDNECPVCPVSVGTGNDTVKCPVMIDNEGKEKHLCWNKNHCQKICPDKCKHCNNKLECCDESCFACRNDNPKICTVCPDYTYGHGLQKTCRQDCPHGLYKYFKRRCIDKNQCLTMHKPIELQTTNYYPEPYKIYEKSCILECPPDHTEHNRTCVPCGGRCKKSCPGLVVDSIATSSQLRGCTHIDGSLFIQIRGGANITELEANLKTIEEISGYLKVVRSFSLLSLSFLKSLKLIKGEELDNGKYVFSVFDNQNLQDLWDWNTRPPLKIKSGKLFFHFNPKLCYEKILTLQEKAGLGNFTDLEVAKNSNGDKTACNITPLDVKVTNIESNSSTLEWKAFFLDDPRKLLAYIISYTEAPFKNISQYDSKDACGQDNWKVVDTPNKEEEDVITYKIKNLESYTQYAFYVKTYTIASERNGAQSEIQYFRTLPSMPLPPSNLNVISNASDSLYITWGPPSRPNGPITHYEIRKKIRDDQSYNQEHDYCSDHTPKEEAHSTTKPPPLHNCQCESSTQSTTQFDEGAEERIQFEDNLLNQVYLKRPGKREKREAVLYTNSSLQESTDNPAKYLKNDTEHVYKTKNTNYYLKNLHHYTMYDVHVWACRDDECSVAAMRSFRTKEKVGADVISNLTLVHKTQDSVTISWHQPKDPNGNIYAYIIESKKIDLDNAKAVPECINVTSRNVTLYYTVSKLIPGNYSLCIFAKSSPNRKEQSNYIYFYIDEPSSNTALVVSILMFILIMGLIFFGWLYKKTQRKPVLFPEINPEYVPNPYVKDEWEVSRDQILLNKELGQGSFGMVWEGLARDIRGKSEVRCAVKTVNVHATDRERLEFLNEASVMKAFDTTHVVRLLGVVSEGQPTLVIMELMANGDLKSYLRSHRPDMENYNSALIKHPPSLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVSEDLVVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMAPESLKDGVFTSYSDVWSYGVVLWEMATLASQPYQGLANDQVLRYVIDGGVMERPENCPDKLYTLMRYCWQHKPSSRPTFLKLCQLLLEDSSPVFSEVSFYHSPAGVEARASRHTPSPSQDDQTTPLRHVAERLKGYLPSNSNDSDELDINTHHQFPSISESEGIMTTANGYVSGCPTNGAATTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJW7</accession>
    <name>A0ABM5JJW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mucin-2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498234.1">
        <property type="nucleotide sequence ID" value="XM_050642277.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642277.1">
        <property type="protein sequence ID" value="XP_050498234.1"/>
        <property type="gene ID" value="LOC126879220"/>
    </dbReference>
    <dbReference type="GeneID" id="126879220"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046849100" description="Mucin-2-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113504" checksum="60CB1FF5079478BF" modified="2025-10-08" version="1">MWLLILLTYIMIIAPWESAAITNKRTSTRYLEQSDSVRYFRHIPPRPTEEKLSDWEVGLREAIHQALLREGYWEPNLRERLTGAQLIGRQDHATPFGDVAVLARGQLYAIHAGNFMLLQDPYQNDCDDCYNPRRCERHDCQPYSPHNQEILVALWTVKRIRHRDVDRTRFDLEYIVSPLNANNDQIIMRRGKFNYAIPGHVFAVRSGKSEKNYPEVYNRKIPQNNFKPQVPLGVDSEGHRNVLYSYPGFFTSLPAQYLPPGVSDDTQEAQLYKKLLEALASKTSTTQQESSHVSTTTSMEETTKVTGSSQEQIPTTPSMPTSPMTISATASTVPETVPTMKTTITYYMPTGEEILMPETELPTTQKFSPTTKPSSRPTKKYTTKSKTTKIPNSTKKPTKTTFSTTKRPTTTPKTSQLPSSTKKPIKTTISTTKTPTTTSIIPSTTKMYVKPLSRTPTSPTTTKIIKTSTTPIPVTTSRPMTQKTSTKRPSGFTKFTKPSRKTTIPITTVTTTTRVTTTSPMPPTVISTQYQAPTKTTEHAEGTSTEYQTSPQPTASTEVISTQYQAPTKTTIPSTEMPTTIVTTTSPTTLMSTTSPQVEETSTEPATVTEETGTTKITTTNFETTSTTLPSTEYETKLPTAEITTEKTTVPEETVTTSLESTSTETTTQTPFSTMTTTASTTTKTTTKPTSRRTTTPSDFLTEAEPYNGPIYVGSVKNDYSLDDIFGPTTQTEKPTSTSTTRHTESDISQQLFGGELPENSKIIFSGFYEASTTANEDNDRKKKASQILTSQSYETEVSYEVNKRSNTESVGVLTTSTLRTPTKPMFRKSLKNRKFDYTRKKPSRALKTTSTTTAVETTTMESTSVQKVTTEGTALFADPPVEESVATTTQAVEETSNREKELEVFTKGAPANILIPPPETPTRAIVKQMPTNRTDFVIYKAEYPDEATQVSIPENTKDVFDDLALRLVSHAKGLEYLNRTNRTAKVAKYRRRKPYVSRSNKRPVRKKKEPEEEQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKL2</accession>
    <name>A0ABM5JKL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050498478.1">
        <property type="nucleotide sequence ID" value="XM_050642521.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642521.1">
        <property type="protein sequence ID" value="XP_050498478.1"/>
        <property type="gene ID" value="LOC126879484"/>
    </dbReference>
    <dbReference type="GeneID" id="126879484"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057368">
        <property type="entry name" value="USP32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25265">
        <property type="entry name" value="USP32_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="7">
        <location>
            <begin position="404"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="762"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1532"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1532"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1582"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1690" mass="189789" checksum="D7A6D1FFE4803520" modified="2025-10-08" version="1">MGAKDSKRSCLSYDDAVKRMSDAEYRRVCATFKRLTNGGQLLSRHAFTQNVLGDGVPLTIADWLYTACGGTTRGIALRDLICGLVLLTKGTQEEKIKFLWTLYCNDSATHLTRSEFKTALQIEGGLPPDSKSSNASGDRTVISLFSNQDKVSFEDFRAWITYKKESTILSKWLLSNPCVSLSSELETPTFYQTLAGVTHLEEQDICELEKCFWALQASSATSNLDFNCLKSRVCPPVPLKACKGLFLALDVNRDDHVDFKELCCGISAACRGPMVERMKFCFKIFDMDRDCYLNSDEVQHMTQTLIVVANENKLTYFQQFQPDPLPKPDLLTDVMLSETKRSEAVGNGDMHREILACLQSKLDDKGGLTQEDFLVWSVENNSLVAPLLELLFQVCHVSLGLRPHCRHNEYEIVMGWLEREQRRGYHVGQFWYLISSDWWNQWMNYTAAPRTNLDICNCRNESRLPIEEGIACDESLISNTTDYTSTSNDFNSNSMESMGDLLTRGGDRCSISSSSGVSSSSGTGPKRSIGQPGPIDNSSLIAEPMCKVQTLTGEGGRLKRDMPLVQHRDFELVPESLWKALAMWYGGPVPLPRQVILPPGRTEVELELYPVNLKILRHLAQQRISTASWSSVVGGYGAAALSTAGLTSTVNASTRRYLAHTAAFSRLATVQQVTDFLCHRLTLRLEDARLWWLREHAASLLDDENATLEELGIMDADQVLLEVRNKDQTWPEELGQLVAGGGHEVGLSVERRPTIFLPEGATGLHNLGNTCFMNAALQAVSNTRPLTLYFRRDNQLSELNITNPSGSKGAVARRYAELCRELWAGSTRSVAPLKLRYLVTKYSPYFQDGGQHDSQELLAWLLDTLHEDLNRVAVKQYTALKDSNGRPDEIVAEEAWEQHLSRDHSIITDLFYGQLKSKVTCQTCGHESVRFDIFNVLSLPLPMESYTLCEVLVVRLNGECPVKYGMRLQSEAKYIELKEHLYNICSIKPQSLLVAEVASSQICNIPADDAKINPTTATELYAYELPETIEVVPKAEIEIEPDVELEICDSPLARSPEVSHGSALCMPNILCFKNNRSKQGNQEPRISNISYKKPSISVNSNTSTASASSDSSRKCPSYLIGVHRKCVRQETYFLSQQKSKPSLFGMPLLLGFNGRSSCQSLYEEVWNQVTRLLSPLPQSDQPNHATDCDDSLGYEFPFTLKAVLQGGQICAICHWTQFCRGCIIPCSEELLVNLCSSSLNNMCISIDWDPTALHLRYQTSREKTWLEHESVGTCRKLHAEPIDLDYCLRAFTSEERLETKYHCSSCQDHQPATKKMQIWRLPPILIIHLKRFVFVNNKWVKTQKVVNFPFKNFDPTSYLASVPQETILRHRQLLAKKNEELEKSTDSQPERILEENEECSSETKCNVQDKCKGKCVTDANSPLESCKLLNDSDKGKGNKLADRNSKVRARLESTSLIKTPIIDEHLKDYHRHQLKPGQDAFDLKYQLYAAVCHSGMLNGGHYISYACNPNGHWYCYNDSSCREVLPDPEINSNKSTLSLSSTTSSKPSSCTPLAKRKNIRKLSSGSMASEDLEKKEGNVNMSSTETLSSSRSNSVGSVDKLGTNVDSYNEKLLSESPYSSRKSLNNYKCPYRDVKVPKIDTSTAYILFYERSGLDYDPYLPKVVPNGKEMPLDDLDETDSELRKQICSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNR0</accession>
    <name>A0ABM5JNR0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499573.1">
        <property type="nucleotide sequence ID" value="XM_050643616.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643616.1">
        <property type="protein sequence ID" value="XP_050499573.1"/>
        <property type="gene ID" value="LOC126880034"/>
    </dbReference>
    <dbReference type="GeneID" id="126880034"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="402" mass="46804" checksum="AD0022490F9F353C" modified="2025-10-08" version="1">MAYFYWYFRPWAILLCLVGIFPLEHIFKSDPTMLKYRFFSLSNLYSSFLFVSLNFVFIRYGAVLFMVNSATQKCFQLVVYITSIRALFAVLTFLKTSKKSPTLIKLLHSYDHQKQDFVIAKDECKIKSIFVWTIFPMLMSCFFLISFAIYTTKIAQDVLRSDRDTLAYLQTGKLAAASLGLLSIWYIFPNSLYIYQCSRIAYNFSQLNQSLKIKLFSEEYGLQEKICVDYEIMERYRYLHNMLSECVHSLEYIYGYFLVGEMVAVIAVIVINISVAIIVDYNSVNLIIYCSHSILLMLIVISTTHKLKEEGNEIVNILHRMPTKSISDECLKELQTFMIQIHVRPVEISASGYFTLDKRQILNIITQVSTYLIVVCQLVQSYYQYNNQQNSNSTHIVNTDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JP93</accession>
    <name>A0ABM5JP93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DC-STAMP domain-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499762.1">
        <property type="nucleotide sequence ID" value="XM_050643805.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643805.1">
        <property type="protein sequence ID" value="XP_050499762.1"/>
        <property type="gene ID" value="LOC114333517"/>
    </dbReference>
    <dbReference type="GeneID" id="114333517"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="7">
        <location>
            <begin position="412"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="8">
        <location>
            <begin position="654"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1147" mass="132027" checksum="D43E84AE377001B7" modified="2025-10-08" version="1">MAFVRLIFTAQRLQQSKKDLIEEKQDAIKYYTTSKRKFKFHHVHIRFRQKLKRLWRRIGYCCCCQKFCFNLKHEGSVENYVLKSIAGFFGGLILTYIFFMLFVLQLSFTFSSATILCSILGCVLVNGLAFSSKVRCVVLLTLPHFFSERGRQLLVAYALLLVISGPAKNTLNNLGILSESLACGQEQLKTVVRQIIEVIKKPFYALKDAIKKVIETVKKIIKQIKEILIKIKRIVMSIVRVIKSAFMFLAKIINICNKELGTPFERCSRVFDNAIADCNATLGSFFSWMCSVTYIVKAVCYVVKIFDFVCIIVDFIKDSIIGVVIRKIKGFVRHIRTMFYVRIKFSHSFSFETQSSKSISEISKAIVQEIKDRTKTVVAAFQIFTSTASLFFIFMIVKVIVYRYRFLTSDSFDNKFITEDFFKIDLRRAKNNRETVLPLNSREKKLYVKIKSSKLTDIEKKKLKKAVMTLASVNMKAALYMAIDYCLYWILNMINYYGRFQSKVQAPNIPTPYISGQGLLADLLRSIVKAFQPMGIQIEIDTIPCLPTPIPPNFDRYIQIATLLIFCWVLTLLEPYGLRFRTFIMCYYHPLRGRQRAIWLYNNILRKRNTFLKFARRQLKRKFLGSKDVEKVTLKEFLAANFRCLAICLDKPQKACLLCGKVFRESDAEKPIQCQTPECLGLYCAECFADLRNLCTVCLSPIEYGDLSDLSEERDSSEDERIALKKKGTKDKKSKSKSSCKSLFNICSRKRSTYSDTTPLLPISLKDTTPTGVLSKLSLRRSQNINEDESLFQKSLELDRVPPEDFNVDEESVSLLSKEEVDELDDVDDEEVLALFKKTSDSGHSSTTSSTELYSYSYQYQKSEQKLNSWEIPSRDVEKQDIPDYASMDTFREESDEEFVASENLDESISEGEIEDEYKFSRTKYSSTLTNVEELPLDTDAIQKSYTEMDSTEKERVDVGTSISGDTISRAKQNKRIEFIGVQERDSPKRKIKRKKKRKLDSSKCFCSTSEEELQPLYRGTKKSTISISTSPKRERHSTKTKQCISSCDHQVSKCNFPTDCSNEEENTTNSNWYEQPFEVDSLIDMGTATSSKNYKESENIELKDVSNKGESSQFDSGTSGQEKKKSNKLKMFFGKVMPKYKIQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ33</accession>
    <name>A0ABM5JQ33_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500052.1">
        <property type="nucleotide sequence ID" value="XM_050644095.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644095.1">
        <property type="protein sequence ID" value="XP_050500052.1"/>
        <property type="gene ID" value="LOC126880300"/>
    </dbReference>
    <dbReference type="GeneID" id="126880300"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="130" mass="15151" checksum="DB4114F186932D5D" modified="2025-10-08" version="1">MNEKKESPTNSRTAKIMSLVKHLIFLPKYETTKGLSSENRNTAITLLRNNEGNLDDEHNSTNLEKEKNMKGIVKVLENKLKDKKENYNEVEYIEKQKTKNSEEIRTAHLKGMDNPFLLKMTGYLQYILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQF4</accession>
    <name>A0ABM5JQF4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500170.1">
        <property type="nucleotide sequence ID" value="XM_050644213.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644213.1">
        <property type="protein sequence ID" value="XP_050500170.1"/>
        <property type="gene ID" value="LOC114333923"/>
    </dbReference>
    <dbReference type="GeneID" id="114333923"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="494"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1651" mass="187946" checksum="0DDCD9BDC6492799" modified="2025-10-08" version="1">MSLLQLEVVVWKNYIIRKRHWFLTIIESFLPVCLFLLIAYGRSQITGLNKIEVPNPTYGRIDGINYNIDVAGTYILYTPYNEYYTNITTKMLTKLGMPSDHIQRFGSENELLGYYYKNPNYTTVAIIFDDKNPKHFNYKIRYHKNYYQPEFLVTDRMYQRVYGYSPGSEYVYRDEDFLKIQLALDMSFLEENLRSSNIEDTYSIQIQEFPYPPHKVDSAITTLFLEFLPLITLFSFIFLCPAVLKRVVEEKHSGTKELMKMVGMKSWMLWFGWFIYAMIPMFFAVSVISIFMKVPMFGSDSPLVEFANGGILFVFLILYCMAAVAFCFAISSFFSRPTIALVAGILVWILSFFIPKYACGLDEANKLSWLSNVLLNLLPNMSLHYGYSIISVFEEREVGINWSNFFKPGSGSSDDITMLNVYVMLIVDIVIYTIFTFYMDGVNPGKYGVRKSILFPLQNFMKLCRKPSITTVPVDSETVPLEKVEAGHNLAKGIQINHLHKRYKQKQAVNNLNLDIYKNQITVLLGHNGAGKSTTMSIITGLIPATSGSVTINGLDINTDMDEIRKSLGLCPQHNLLFTDLTVKEHLLFFAKLKGKSTKEANIEAKSLLAKLNMPDKEHSMAQTLSGGMQRKLCLAMALIGDSKVLILDEPSSGMDPQSRRELWDLLLQWRGEKTILITTHFMEEADALGDWIAIMSDGSLNCYGTPMFLKKKYDTGYHLNLMIEEDADIDAISRRVKHFMPDAHLTSNNGNNLVFVLPYQNTNMTGLLGDLEKNRSELHLSNISITITTLEDVFLKTRQEIEHSSDDTSSVATQGLLDLNMPDDIQPHASLTLITLLKKKVNFSLKKWSTYIVPVGVAVVLFSLTVFLSSGNDYYSERGPELPLKLSSYKQTSVYYSGDTSNEKINTLMKYYMSAVESQRSLPFKVDNVEKSILQRSLENIAYYKEHMIAGANFVYDRDFTLVALYNGIATHSTPISLNLITDSLAKTLLGPEYGISVSNWPLPQVQERLSSQEYSEAKVAVLWLILLPVGCLFIHGIFIIFPHTEISTRFLQIQYMAGVKPFFYWLVNWIADMTFYIFLMFILSFLLWICSPVFQHNGTELGYLFSIFLCYGIAGIPFAYIFSRKKTASGAFALFVIMGMFLGIILTLTIAVLLESQDEYYVNIGNKIKYVCFFLLPQVSLSDALVSFIRRTVNIYNFKISPQRLRVMCNQMESHACCVESSIECQNYKSYNNLFSEHYMFMIGCGVFYLTINIILDTYFMKKLKAMVMRQCNLILKSFKDKDTALIPKNDKYVNEDVGDGYNTLRAKKIMKLYAGKQIVKNINFTLKHGHCLGILGVNGAGKTTTFKMLTREEVVDDGEIKIELDNNKQPLDITGSEYLETIGYCPQSDSLNFVLTGRQLLSTVAKLRGVTDETMIDRFLEAFDLKQYADIPCGHYSGGNKRKLSLAISLIGNRKFVLLDEPTNGVDPATRRKCWDLIKLMKGNSGNKIGFILTSHSMTECEALCDELKIMKKGSFVEEGRLVDLKNRYGGFTLKLKLVSNQGQPINLVDDDVDEVDGVISNKFKSVDDLKSYFTNHDRGEIKDEHSGLLHVYIKDKTKKWSDIFQEVEALKTHNSHLIEDYAISEASLEDVFLKVAREDEEDVTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSD6</accession>
    <name>A0ABM5JSD6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500858.1">
        <property type="nucleotide sequence ID" value="XM_050644901.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644901.1">
        <property type="protein sequence ID" value="XP_050500858.1"/>
        <property type="gene ID" value="LOC126880835"/>
    </dbReference>
    <dbReference type="GeneID" id="126880835"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="439" mass="51084" checksum="36411B5216C45557" modified="2025-10-08" version="1">MSTNKHNSEQTGVSEDDHRRDTDNGTDMENENRKKQSPDDLKWEEGMNSFERELINSHKKKQKMNRSTAPKQSTLVGDEMLESSENDDDEIGEERSQEEVEKIEKGWQNIQERVLASFLLDDETMNKKKRKGDSLERINDLKRERLEESIKFPNETKQQKINRKLEELNIKLIEIFTNLSEKKGEKVEMDTELKKLLGVIKSTNNKKEDDSIAEKTQKEVKCDHCKLKVEQERQREEQEKIKRALNMGGGKKTFMSICNSKWEEKAYIKTNWEQGGLRETVEKKTCLIVTKKDAKDKGVENIIKDVGEDLAETLEEVNEGEIKFLENFRRKENKKTIWYTFVAGIEKESGGDIYDLAEKAITKIKKEMDETPKVVRVVAGNDLNKEIIRKALEYVGRRESISWEMIVRGKELEVEKKSEQEEALLIKMGGKNITKFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JV10</accession>
    <name>A0ABM5JV10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501778.1">
        <property type="nucleotide sequence ID" value="XM_050645821.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645821.1">
        <property type="protein sequence ID" value="XP_050501778.1"/>
        <property type="gene ID" value="LOC126881519"/>
    </dbReference>
    <dbReference type="GeneID" id="126881519"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06721">
        <property type="entry name" value="PDZ1_syntenin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06794">
        <property type="entry name" value="PDZ2_syntenin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051230">
        <property type="entry name" value="APP-Binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345:SF3">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12345">
        <property type="entry name" value="SYNTENIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="125"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="309" mass="33672" checksum="F3187F2B3386EF58" modified="2025-10-08" version="1">MSLYPSLEDMKMDQMANAQYSQIQRSIAAPQATAPGAPPPYTYPGFDSMPVPALGADKQLYPSLGEFMGLELSEAVIAENMPEYSQVVLYQQSVVPQTTSTGLIAPISGQSVGLQRAQVTHGVRQLILCKDKDNKVGVRVKSINKGVFVCVVVENSPAAMAGLRFGDQILQINDENVAGYTMEKVHAMFKKSPVNGINVVVRDRPFERTITLHKDSVGCIGFQYKNGKIITIVKDSSAARNGVLIEHQLLEVDGQNVVGLKDKEITNIIQKAGPVVTITVIPSFLYDHMIKSMKGSLLKDLMDHSIPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWP9</accession>
    <name>A0ABM5JWP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Filaggrin-2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502357.1">
        <property type="nucleotide sequence ID" value="XM_050646400.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646400.1">
        <property type="protein sequence ID" value="XP_050502357.1"/>
        <property type="gene ID" value="LOC126881816"/>
    </dbReference>
    <dbReference type="GeneID" id="126881816"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="72254" checksum="27BEB69AF4195AD6" modified="2025-10-08" version="1">MCWNKKGISITCTVSIRSDEAIPSIVKLIIYCIFLLVFSSSGILAHPYGASTGQTKGGLNLGMGLELEGNGHDANSQNKGLPGVGAHVKANVDIAGVHLGYDEGVDLGGSKGIALTKQVDVAGHKVGVEQNEINLGQKKGQGLKGPGEGHIGTLQGDLSGKTEVHGATNSNQDVLTKTVNGIFGINKQDSQRTDANIQTGYTHNTNQDGALTKTVNGIFGVTKQGSQRGESNIQTGYTHNTNQDGLLTKTVNGIFGLNKQDSQTGGASINKNTEGKATSIDTNQANTHSYGLGSYGGSSGTTRGNSNGNTLDISQQHTSFGKQTQGGGSYSGSSSHSWSTSESRHSHTSGGSKGSSLNFGGRPFFDDHSAESSEMVTSGGSHSITHNHGHDHSHASGSSRGNVVHFGGRPFFDDHSAESSERITSGSSHSTKVITHDHGHDHHSHGSGSSRGNVVHFGGRPFFDDHSADSSEVITSGGSHSTRGNTRIHDQHRSSGNSRGGSVHFGNRTFYDDHSAESSEEIGYGSSHSSNNQRHGTSSYGFNSGVSGKHEAGGSYGTGHSSGGYGHGGYGSGHPSSGEYVHRITDGINVNGHHSGHGSGHSSVVESGHTGGIGLGLAGSHRSTGSHESGGGYSHGIGLGIGIGSNHRGSSGETGLHGHGVDGHLVVGGYGTGSSDRETGAGLGLGIGVKGGHNTNSGYGHSSYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYL4</accession>
    <name>A0ABM5JYL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503033.1">
        <property type="nucleotide sequence ID" value="XM_050647076.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647076.1">
        <property type="protein sequence ID" value="XP_050503033.1"/>
        <property type="gene ID" value="LOC126882250"/>
    </dbReference>
    <dbReference type="GeneID" id="126882250"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
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        <property type="entry name" value="C2H2-ZF_domain"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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            <begin position="180"/>
            <end position="207"/>
        </location>
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        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="234"/>
            <end position="261"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
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        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
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        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
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            <end position="652"/>
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        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="767" mass="89933" checksum="D2B058038AD62785" modified="2025-10-08" version="1">MEKQEDNYTNNEVSNIKCETEFENNGVNNTEFPVTIKNEFKQEMLLPEDDTTNDDSKDWFIQMNTAVSVEDVKHEQIEDDGDLVNCKNLKSEPNIKEEEDIIEEKQSQCGSSSEEIHNDANSDLKSNKRLVGEDTKTVDTSFTCEICSKQYFLEHNLKRHMKSHDGEDKRHNDEEKEKPFECDVCFKRFKTNLEVKSHMRTHTGETFKCELCPKEYFSNYSLKLHMRWHTGETFSCKICSKQFVRSSKFNAHMLKHSEGSKERRFTCVICSETFSTIYNLRRHSRWHTGETYTCEICSKQFVDRHYFNIHLRLHTGAKPFQCEICSKHFSHKSGVKVHMRTHTGEKPFSCEICSKQCVTSSDLKVHMRKHTKEVPYECEICPKKYATSSGLKKHMEKRPFKCETCLRHYKTNKDLQLHIKLHTGGETFSCEVGSKLLSTYSSLRVQLRTHTERIPFTCEVCSKGFFSSATLKLHMTVHTKELFPCELCPKQFITKSKLKIHIMRMHTDDRPFPCKVCPKRFAVKNELISHMRWHTRDVLFTCEICSKQFVTRTVLTRHIMRIHTAEKPFKCEICNKQFIIKTELTNHMITHTGEKPFSCEICCKQFVVKRSLTDHMITHTGENPFSCEICYKQFVGKRSLTNHMITHTRGKPFSCEICYKQFVVKRSLTNHMITHTGEKPFSCEICCKQFVYKISLNNHMITHTGGKPFSCEICCQQFVTKISLSNHMRTHPREKPFSCEICCKQFDIKRSLNRHMRTHTEENPIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZL0</accession>
    <name>A0ABM5JZL0_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">Protein takeout-like</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503376.1">
        <property type="nucleotide sequence ID" value="XM_050647419.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050503376.1"/>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046570479" description="Protein takeout-like" evidence="1">
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            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503376.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27135" checksum="6C60F452974DC37C" modified="2025-10-08" version="1">MKYFVFLCLIGYCAAKDLPNYFDVCKPKETDISKCIMQNIEKIRLKLDDGLPEMGIPSINPLEIPSAELNIGKEFKASMKDIKLYGINAFIVKQLKIDLDKSYIEIKVVIPHIRTEGEYNVNGKLLILTLDGSGPGQINITNLEISLIGHGKKEMKNGKTFLKIKSMDITSKIGKVILELKNLFKGNPELTDNSNKLLNDNQEILVEQFAPVVVDIMKKFLSEKISYVFNKYSQDALFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZP9</accession>
    <name>A0ABM5JZP9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503410.1">
        <property type="nucleotide sequence ID" value="XM_050647453.1"/>
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        <property type="protein sequence ID" value="XP_050503410.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="388" mass="42898" checksum="9E551A62005DC5E5" modified="2025-10-08" version="1">MTSNNTMNTTQTTSHISYSSVVNTFKQPTKDEAIVLSSIEGIKVQEHIIAVGSIVGPCNVSFASRIANNRICIYLSSKNMVDSLLHSHKYVNIKETQVEIRRLITPAQRLIISNAGPSVPTTLIEQELRKMGINAVSKMTFLRETECPDNANTITSNATTSNTTNLDSTNSNPPTSNTTNPDPTNSNTTTSKALPETSQNTQYITNLPYNQTEQKPSDKALISTSNDHSASSQNILDQIPDIQVSNNQLESTIETDDMSRPTNNTNETNTLKIPTSSTFNTISNLTPLEITQPKIIPNVTKHLKRLISSSPEINENTTQTDSHIFTSPVTRKSKKKTKTSRRNSRDELLLSLETIKDKITNRSPPFVLNFDEIFLVTGRAAEKVQTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K004</accession>
    <name>A0ABM5K004_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503519.1">
        <property type="nucleotide sequence ID" value="XM_050647562.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647562.1">
        <property type="protein sequence ID" value="XP_050503519.1"/>
        <property type="gene ID" value="LOC126882589"/>
    </dbReference>
    <dbReference type="GeneID" id="126882589"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="393" mass="43199" checksum="2002E0C9441E63FC" modified="2025-10-08" version="1">MLEPYNPDDVWLIVLGFLIAFVLAFGIGANDVANSFGTSVGSKVLTIFQACCLATVFEISGSILIGYKVSDTMRKGILDINMYKDAEKELMLGSISALTASATWLIVATFFKLPISGTHSIVGATVGYSLVLRGSQGVQWKTLGKIVGSWFISPVFSGITSCILLWIIKRFILTRPDPLEAGLMSLPLFYSFTILINIFSIVHDGPKLLHMDNIPLWMASTISVSIGIFVMVITWLFVVPWQRKVIKEQEVKEEKLAVNFNIGESSDTSPEGSPNRKLNRNSACLERQLTVISESTELQQLDQNRITAAKYIFPVQTTDKHVFTPGAKETEVRKHARPTELKLVESTTSVNPALSPSSSGVPLITKRNSAGRCDQGNRFLRPGDDCAVSTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K095</accession>
    <name>A0ABM5K095_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503610.1">
        <property type="nucleotide sequence ID" value="XM_050647653.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647653.1">
        <property type="protein sequence ID" value="XP_050503610.1"/>
        <property type="gene ID" value="LOC126882679"/>
    </dbReference>
    <dbReference type="GeneID" id="126882679"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42385" checksum="954316DAB64741AD" modified="2025-10-08" version="1">MFFRDSFSSIIHENDALANVQKFHYLQLSLKGEAAETISSLQIGDVNYEVAWSLIKERFENKQLLINFHIKSLFNLPALQQESHTGLRQLLNGLQKHLNALEVLERPTKHWDDILIYLLTSKFDNATRRSWENKINASEIRTLSQLTDFLKDKCRMLQTLETETKQPSNKSNSNFKQREKTRTFLTNTTKQCVFCNNDHNIYHCESFLNLTPSERLNKAKGLRLCINCLNNNHSTKQCRSSGCKKCGKVHNTLLHFPKQPVQQTSVDADIPIEIPQANETSSNYSSLTCHSPAKSQILLSTAMVKVADKNGNLHDCRVLLDSASQSNFISQRLHHILQLPKTKTNTSIFGKYGQENREPVTKMIRRDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0B1</accession>
    <name>A0ABM5K0B1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503627.1">
        <property type="nucleotide sequence ID" value="XM_050647670.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647670.1">
        <property type="protein sequence ID" value="XP_050503627.1"/>
        <property type="gene ID" value="LOC126882693"/>
    </dbReference>
    <dbReference type="GeneID" id="126882693"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="247" mass="28568" checksum="55BCB5BDA20D0BE5" modified="2025-10-08" version="1">MKEDEEKRRQEEKEEKEQRREVKEKRRQEVEEMLSGKSNKIDILEEKQNSLDNRKEQQQNYLDNKIEQQQNYLHSKIDQQQNHLENKIKQQQNDLKQQQNDLKQQQNDLKYSLEKQIVELANKINSQASLSHIVSVTNVESKQTALSSSIVDPGTIRSSKILKPPTFDGQTAWETYRFQFKAAARANGWNENEMAASLVVSLRGQAATVLQFLPQGAPSYTSLVQACFRDKIWPATSKTGFPKSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0K6</accession>
    <name>A0ABM5K0K6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050503722.1">
        <property type="nucleotide sequence ID" value="XM_050647765.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647765.1">
        <property type="protein sequence ID" value="XP_050503722.1"/>
        <property type="gene ID" value="LOC126882768"/>
    </dbReference>
    <dbReference type="GeneID" id="126882768"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF91">
        <property type="entry name" value="ALKALINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045507503" description="alkaline phosphatase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="534" mass="59883" checksum="9C4E5FFF6D5EDF95" modified="2025-10-08" version="1">MQMYKLSVVVVLFVVVGEVLSKQKNKDKGRLEQPLNIYQDDEFPFPYKPVRSRSENEIAAEKDKQFWYRKAASAIQDRLARKINQNIAKNVILFLGDGMSIPTISATRVYIGGEEQQLSFEKFPYTGFSKTYCVDHQTADSACSATAYLGGVKGNRGTVGVTAAVNKSNCTAMNDPNNHVESIARLFQLKNKRTGLVTTTRVTHASPAGVYAHTANRHWESDTDVLDDHENPKECEDIAHQLVFGETGKHLNVILGGGRKKFIPAYVKDEEGKRGHRSDHLDLIRLWMEQKETMKASYEYVWNKEQLLNLRNDTEYLLGLFEPNHMPYNLERDNETDPSLEEMTEAAIEVLQRGPEGYFLFVEGGKIDKAHHASAPHKALDETAEFAKAVQRAVELTNEEDTLIVVTADHAHTMSYAGYAKRGSDVFGYGGIANDDDYYTILSYANGPGYKSRKNKKRYVPSEGDLDKISTKWPALAPLRVETHGADDVGIFVRGPKAHHFTGVMEQNVLPHLMALAACVTENSLCDNNYIKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K185</accession>
    <name>A0ABM5K185_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503949.1">
        <property type="nucleotide sequence ID" value="XM_050647992.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647992.1">
        <property type="protein sequence ID" value="XP_050503949.1"/>
        <property type="gene ID" value="LOC126882915"/>
    </dbReference>
    <dbReference type="GeneID" id="126882915"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042401">
        <property type="entry name" value="SPMAP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006623">
        <property type="entry name" value="THEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15901">
        <property type="entry name" value="TESTICULAR HAPLOID EXPRESSED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15901:SF16">
        <property type="entry name" value="TESTICULAR HAPLOID EXPRESSED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14912">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00705">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="138" mass="16569" checksum="6185A6009C03B284" modified="2025-10-08" version="1">MVCSKHSNIPENFCRILTPKRKAPNKHRHKKWLRQDSNYLYNARQQQIKELRKIKNRLKEENALIKIKESALNYKASARIISLAQPKFERKKLIQMEGTMSYVSPSALRYMPTRRILELAKPKYISEKREMIWQHTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3N3</accession>
    <name>A0ABM5K3N3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504798.1">
        <property type="nucleotide sequence ID" value="XM_050648841.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648841.1">
        <property type="protein sequence ID" value="XP_050504798.1"/>
        <property type="gene ID" value="LOC114330241"/>
    </dbReference>
    <dbReference type="GeneID" id="114330241"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13105" checksum="3AF8F80A5F990EC0" modified="2025-10-08" version="1">MQFFPNLLAKRLSNVCHTGGQGIPPPSHIGGYKLYKRLFFLLGLPIIGLVTAFNVYQKKQQDECDRPPFVKYEYLRKRDKRFPWGDGDKTLFHNPMKNPLADGYEDELEEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4H9</accession>
    <name>A0ABM5K4H9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505092.1">
        <property type="nucleotide sequence ID" value="XM_050649135.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649135.1">
        <property type="protein sequence ID" value="XP_050505092.1"/>
        <property type="gene ID" value="LOC126883521"/>
    </dbReference>
    <dbReference type="GeneID" id="126883521"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="221" mass="25591" checksum="0CB75A1C75EAC2B1" modified="2025-10-08" version="1">MREFYDFFLNQNNSEQIKEFCTQNSITFKMGVPRNPHQFGLHEVGIKSVKYHLYRIIGNSHFTFEVFNTVLCQIEAILNSRPITRMSSDANDFAFLSPAHFLVQRSLTAPPEPSVSEIPENRLNLFQRISKIQRQFWKLWKKDYLCLLQQRNKWTDPTDPVKIGDLVLLKEDGTPPLLWPTARVIDVLPGKDGLVRTVKIHTTHGDFLRGITKIAVIPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K553</accession>
    <name>A0ABM5K553_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505317.1">
        <property type="nucleotide sequence ID" value="XM_050649360.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649360.1">
        <property type="protein sequence ID" value="XP_050505317.1"/>
        <property type="gene ID" value="LOC126883699"/>
    </dbReference>
    <dbReference type="GeneID" id="126883699"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16923" checksum="E555386993DAD3DA" modified="2025-10-08" version="1">MINDQQKVTETWKHYFPTLLGTQVDVEDEIGMNYVEENEVDNGVEAPSRGHSPKNSRGKCKCIKLSVDLELYGLITLQIQKYNEQKVLDQLKRDQTADKKDILATGGGTFIPRLTYVGAQMLSLIGNQIQPLPNSCDSASGFFTSDESLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K593</accession>
    <name>A0ABM5K593_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505360.1">
        <property type="nucleotide sequence ID" value="XM_050649403.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649403.1">
        <property type="protein sequence ID" value="XP_050505360.1"/>
        <property type="gene ID" value="LOC126883741"/>
    </dbReference>
    <dbReference type="GeneID" id="126883741"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="448" mass="51747" checksum="DABE38BD2F1D67CC" modified="2025-10-08" version="1">MAEVGDEVDRLKQELEKAREEVCKLQDERQRVAQNELNYLRKEMEELRMAGNRRVEMIGAREVKEWCGSEGEMSVEEFVERVEMLQQINGWTEQNTADLVRRRMIGESAEFLRNATSQKQEGWTWKEIKGLLLQRFGVKKDRVEEMAKLMNIRRKEGENYRRFADRCRTAARYVVKEYEKEEEKQVANEIREEMILGVFMEGLNSEVRRVVKARKGVNTLTVVLDMLKDIGEEGDRKRVRKVKKELEEEEANSSGSEESFATIVSNSSERRGIRRIEGGKKEGFVKMNRADAIVAGGSKWHDRANPAGEVQGERQRSLRRVPYTPCRRCGQVGHWTRECTIHLGNQKSGESRWKPEEGTRVGKRASNEECFQCGRLGHFINTCPQTICDNCGYGGHVWRQCQNTGTSARRGPFSRRQRPWESDKSDRGVEDYASLAGRRAESRSVSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K637</accession>
    <name>A0ABM5K637_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505650.1">
        <property type="nucleotide sequence ID" value="XM_050649693.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649693.1">
        <property type="protein sequence ID" value="XP_050505650.1"/>
        <property type="gene ID" value="LOC126883921"/>
    </dbReference>
    <dbReference type="GeneID" id="126883921"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69360">
        <property type="entry name" value="Cell wall binding repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="541" mass="61085" checksum="CB655E9CACCC54FA" modified="2025-10-08" version="1">MVRGKWCEVNGARQLVRGNWCEANGARQMVRGKWCEVNGARQLVRGKWCEANGARRMVRDEWCEANGARQMVRGKWCEANGARQLVRGKWCEANGARQMVRGKWCKATGARQMVRGKWCEANGARRTVRDEWCEASGARQMVRGKWCEANGAGRMVRGKWCEANGARQVVRGKWCEANGARQLVRGKWCEANGASQMVRGKWCEATGARQLVRGKWCEANGARRMVRDGARQMVRGEWCGTNGARQMVPGKWCEANGARRMVRDEWCGTNGARQMVRGKWCEASGARQMVRGKWCEANGARQLVRGKWCEANGARQMVRGKWCEANGARRMVRDEWCEANGARQMVRGKWCEANGARQMVRGKWCEATGARQMVRGKWCEVNGARQLVRGNWCEANGARQMVRGKWCEANGAGWCEANGARQMVRGKWCEANGARQMVRGKWCEATGARQMVRGKWCEVNGARQLVRGNWCEANGARQMVRGEWCGMVRGKWCEANGARQMVRGKWCKVNGARQMVRGKWCEATGARQMVRGKFTVLEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7P7</accession>
    <name>A0ABM5K7P7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050506216.1">
        <property type="nucleotide sequence ID" value="XM_050650259.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650259.1">
        <property type="protein sequence ID" value="XP_050506216.1"/>
        <property type="gene ID" value="LOC126884320"/>
    </dbReference>
    <dbReference type="GeneID" id="126884320"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="6">
        <location>
            <begin position="35"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="7">
        <location>
            <begin position="421"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="8">
        <location>
            <begin position="561"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="645" mass="73913" checksum="B60E71B7E8595ED6" modified="2025-10-08" version="1">MSLSSVNVTAGLPTNYGYYTSEGISQGLNADRSTFTLNNKEISIYSGAMHYFRVPRAYWRDRLRKMRAAGLNTVETYIPWNLHEPRSGEFDFGDNGNDMSDFLHLQEFLKTAQEEDLFTIVRSGPFICAEYEFGGHPSWLLRHDDIDMRTTNPTYVNFVARWFNVLLPILAAFQFTKGGPIIMFQVENEYSISGRHDLQYLLTLKDLMIKNGIVELLVTSDNPQHGTYGTLPDNFLMTGNFDTDIKKNLDTLKSYQPNRPVMTMEYWGGWFDYWGDSHTTNKTVENFRYNYEEILKYPSSVNIYMFHGGTNFAFLNGAENLKFDEWETDYHSIVSSYEYVSPLDESGDYTEKYWAAKQLLEQYNRIKTALPDVPAAPKKTAYATVKMEQEMFLYDMLQTITPTYSKNVIPMEKLDINNGNGQSYGYIVYRKTNLNIPANAILKIEGRICDTAMVLVNGILVSPWLQKSADLNGFGTSRILDSTITLTSEDLTGATLDIVVENWGRVNVGVYRQFKGIWQGNGIKLNNDYIYDWAIYPLEFKSSWTNNLSNWKNVLTNSIGPAMYRGTLTINGTPEDTFVYMENWKKGIVIINGFVLGRYARMGPLQTLYLPAPFLKSGSNSIIIFEHFKPYATVDFKTSHVYNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K876</accession>
    <name>A0ABM5K876_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050506389.1">
        <property type="nucleotide sequence ID" value="XM_050650432.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650432.1">
        <property type="protein sequence ID" value="XP_050506389.1"/>
        <property type="gene ID" value="LOC114336694"/>
    </dbReference>
    <dbReference type="GeneID" id="114336694"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="421"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="625" mass="69843" checksum="84CE613C1B012DC2" modified="2025-10-08" version="1">MYQNACGAAAASAGGCVETDRECHSLISKEPTIPAVEHDYSGFDIVKATQYGALARVKELIEAGYDVNERDAENVTLLHWASINNRKEIMSLFIDKGAEVDAIGGELQATPLHWATRQGHLDAAVLLMNAGADPTLRDAEGCSCIHLAAQFGHTALVAYFVARGVSPDLVDRVGMTPLMWAVWKICSLDPTRLLLTLGASTNLTDQQGNTALHWAILARNTTAISTLILQGHASLYTPNNRGETPLSMLQSQVGSIWVSPKVTEVIKEHSHISKSPSFLYKITKDKRMKWWCMVGTPFMAFYIAGAILGTNLIILIKVFLLVCLYIVIHYVAQVLYDDRLMALLPLSIYLSTKAWFYFTWLIYITPVTHILLTVVFLSSSGMLWYCFLKSWLGDAGVVNTSQQLQFRTIIELAERGPGGFEPSSFCSACLVRRPLRSKHCAVCNHCVARFDHHCPWVANCIGAKNHKHFIGFLASLVIMCLQLLYGSVKYWQNAPDCNITSTSDSFWKSVVTIGQCNTWVAWVAVNALFHSIWVFMLFVCQMYQITCLGMTTNERMNRGRYAHFISNGGKSPFTKGPLINLIEFFECSCFGIAKPEQKDWLTSFSLDKNIEQQPLLRHKDTFQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K910</accession>
    <name>A0ABM5K910_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506674.1">
        <property type="nucleotide sequence ID" value="XM_050650717.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650717.1">
        <property type="protein sequence ID" value="XP_050506674.1"/>
        <property type="gene ID" value="LOC126884650"/>
    </dbReference>
    <dbReference type="GeneID" id="126884650"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19270" checksum="CFFDA81D6B4510F7" modified="2025-10-08" version="1">MKLPFHSFIGPVLRKNQKSIRTICSHPTLSFSPFYVLILGLLGVILSVFDIVRIIKCGSVLPGPLLKERLKSGTLVPSEVERDLKLICLVLSTEYYLFLLIGLITGNAIFFLPFMILYAVIIILECSIFAMKSCVEGMDFKKSGLLMSMFMMYNWTSVFCTFCRQTTGCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCR0</accession>
    <name>A0ABM5KCR0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DEK-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507979.1">
        <property type="nucleotide sequence ID" value="XM_050652022.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652022.1">
        <property type="protein sequence ID" value="XP_050507979.1"/>
        <property type="gene ID" value="LOC126885451"/>
    </dbReference>
    <dbReference type="GeneID" id="126885451"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF1">
        <property type="entry name" value="PROTEIN DEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17897" checksum="AE34D75F759D882C" modified="2025-10-08" version="1">MQSKQSLNDFPKISLNLKNSALSAVKALHVVAYGDKGLPRQTRKNLRNFTKFSWDKESEEYCTKIKDVKNKLSMPDLVAVCSVLDLNYTGSEDDVIERICSFLNDFNLEDENDDEDGDASDDDGDKDIYHKENGKDVTEDDRYNEDNDANSDKDAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCV5</accession>
    <name>A0ABM5KCV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508023.1">
        <property type="nucleotide sequence ID" value="XM_050652066.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652066.1">
        <property type="protein sequence ID" value="XP_050508023.1"/>
        <property type="gene ID" value="LOC126885489"/>
    </dbReference>
    <dbReference type="GeneID" id="126885489"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="253" mass="28331" checksum="4070843A8E76E090" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYIVANLDTAYILEVRDIIVSPPATERYEKLKSELIKRLSASQQQKIKRLLEHEELGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAPRAQISEASNALESTIEKLTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRGRPYPRDRSYSRERNSDICWYHYRFGDQAQKCSPPCKLQGNIAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDA5</accession>
    <name>A0ABM5KDA5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508169.1">
        <property type="nucleotide sequence ID" value="XM_050652212.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652212.1">
        <property type="protein sequence ID" value="XP_050508169.1"/>
        <property type="gene ID" value="LOC126885608"/>
    </dbReference>
    <dbReference type="GeneID" id="126885608"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="105618" checksum="053AE688124EA15D" modified="2025-10-08" version="1">MTTYERQFKILTAKKETLYTIIQTLYDLSKNLTTDNTIKKFTNLYQSMDSTRTEILKILDEINAVGFDVDENYKPDFQVMSVINEMCCEARAAYTKLKPSTNIVNPTLQQSTQQQCNVHSLLPKITIPDFHGETKEWETFYSIYKPLVHDNFQLTDADKARLLVSHLKGSALSICAGIATSGDNYDTLWKALLEKYHNKRCDKFKAMNPTQRYDLVKNNNLCFLCFSQSHGVRQCLKRPCAQCAKNHHFLLCAGKPEIRGAKENNQNNQPNSGVGIPETGSNNHNSGSVNCAFQNSSFLSRNQEKTVLLATVTVCVLNSPLQNATARFILDNGSQCNLLTTECCKKLGLRYTKINSSVQGLGQNSQSVRGVTDIIIASRFDQTKKYDVQALVIDHITDKLPKTKLNLQTLSEFKNLQLADDKFFEPKSIDGIIGAQFFPILFGGNRILSSSGLGAALETTFGYVIMGQVDTEYSTPINLLTLREETSIEQILTKFWELEQVPKREIPDLDAIECENIYKTTVSRDISGRFTVALPFKSSPKNLGNSRVSAENRLKTLEKRLTKSDSLRADYNKIMQDFLDQGYLKLLEKEDCDLSYYISHHPVIKLESLSTPIRIVLDASCPSDSDVSLNDLLHSGPKLQADISLRTVQQLINEDGKDYPLAKKYISSGLYMDDFLTSVPDEIEAKELYNQSVKLFKGGCFDLVKWSTNLDNLLSEIPLEKRLQNSVTFKSETKVLGMQWDPQRDVLNYRLTTPDKNCTKRKILSLTAKCYDPIGLIAPFILHLKLMIRELWQLKLGWDDSPPDTIKKSWEKVCNEWQDFSKFEVPRHVGAMRDVPIMILGFADASQDGYGGVVYLRVVNSSGEVSVRLVAAKSRCAPLKKTMTIPKLELCAALLLSSLLKLIFENYSKLTHISQLVAYSDSTTVPRPWSFEEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KED0</accession>
    <name>A0ABM5KED0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050508545.1">
        <property type="nucleotide sequence ID" value="XM_050652588.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652588.1">
        <property type="protein sequence ID" value="XP_050508545.1"/>
        <property type="gene ID" value="LOC126885834"/>
    </dbReference>
    <dbReference type="GeneID" id="126885834"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="759" mass="87476" checksum="A5F3B6EE3CAE8FA4" modified="2025-10-08" version="1">MQCYICDVRVRARGFRRVENLDNLPPRFQEIALGRRMNNNLPEANFDIGIVIHINCYRYIIEKIGARNLERLSLEAREDIYMKREIFVGKGALCCSDQINDDSMLDHNIIENLRGNMRNVNLSPKEVSEWFQALRLTAIENTTNRFETDTGIQEDDFKALTNLSKNNFQDLYTYCDEVVVYDRTRVITKKDLVTFLMKLKYNLSDDLLKVLCSYSSRSNVSLTVTAVRTSLCQRFVRENLGLEAIGRQELIRTHVTDFANSLYNPNPDNPQAIIYIDGTYLKIPKSSNFRSLRQTYYLHKGYHLIKPVLIVGPDGYILDVQGPYFSDSRNNDAAILQHHLEDEEQDEVNNLRNWLQPNDIVIVDRGYRDSIHLLNYLGLECHMPPLLPRGQRQLSTENANKARLITKTIWIVEARNGHLKSIFKLFCGLIPVHHVPNIRMFLKIGCSLINKYFPPIQMQGATAELAETMQELAAYENVVKARVEVDLLDLKRIQDDAWIRDLTIGIYQVKLAPSYIQDKLPRENIEHFTFQALLEEQGLLRARVYSRFRQATKHQLWIAFQPLHLENDGDNILIDGYYCTCKTGARTVGSCAHVASVLWYLGYARHDANVSSTSEQEKKQFERLRDTDQDEAKAARNLMNSDLQKAKNEENLEVLTFDLEKTLPLPRIPTNIVFYKRQLWLYNCGIHSGKTGRGYCYVWAEGTAGKGPQEVASVLLKYLQEKLTPQITELILWSHSCGGQNRNIKIVMLLESVLELIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFI6</accession>
    <name>A0ABM5KFI6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508923.1">
        <property type="nucleotide sequence ID" value="XM_050652966.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652966.1">
        <property type="protein sequence ID" value="XP_050508923.1"/>
        <property type="gene ID" value="LOC126886121"/>
    </dbReference>
    <dbReference type="GeneID" id="126886121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="196" mass="23439" checksum="9CDDFFA2043F0809" modified="2025-10-08" version="1">MEWSNEKCIEFVEDYRQFTCLWKASDKDYKDRIKRGDAQQYLVDKYKLGTRKAVNNKIKSFRSYFHRLHAEYKRKRSGDGRDDALPEPNWFLYKYLLFILDGEENRSGKETFTTQRETSSEKEHCEEDESQQDRDSHRESDFQSGLIFDSPPGTPVIRKAENNDIIRKQGPSKRLKSTKPFEDTHRINLQRKLSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGM3</accession>
    <name>A0ABM5KGM3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509335.1">
        <property type="nucleotide sequence ID" value="XM_050653378.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653378.1">
        <property type="protein sequence ID" value="XP_050509335.1"/>
        <property type="gene ID" value="LOC126886437"/>
    </dbReference>
    <dbReference type="GeneID" id="126886437"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="399" mass="46122" checksum="EBB723C26B2004AC" modified="2025-10-08" version="1">MDRSMYGKVVPGTLNPYQCSIKKGTSPGCARRNKQHKKIPIYVVEGHHEVIPFVHKNIGSKHLPVEGSTLIHFDSHPDMLIPLDMPAEYVFDKEKLYDSLSIENWIMPAAYAGHFEHLVWIKPPWAHQIEDSSQIFNIGKDSTNGTIRLDCKETYFVSECLYTNIKDLENSRAVQLDVATLGKKLVNDSDDLNQIRLLISRSDAPVVLDIDLDFFSTGNPFKRMYEEANMYEQLKDIYYYKTPSSKDDSVISESTLTRKKQIDFLYNIFKSLNETKTMPDVKDPSEQWKKVDNLRKKMLEHYEEDDIDWLLVHDAGCTCDDSGLPDHISSMEELEVMFDCFKNFLEILPKPPVIVTISRSTEDDYTPFENVELIQNKVTELLKLRFSCDEPVLQYLNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHH0</accession>
    <name>A0ABM5KHH0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509635.1">
        <property type="nucleotide sequence ID" value="XM_050653678.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509636.1">
        <property type="nucleotide sequence ID" value="XM_050653679.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509637.1">
        <property type="nucleotide sequence ID" value="XM_050653680.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653678.1">
        <property type="protein sequence ID" value="XP_050509635.1"/>
        <property type="gene ID" value="LOC126886682"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653679.1">
        <property type="protein sequence ID" value="XP_050509636.1"/>
        <property type="gene ID" value="LOC126886682"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653680.1">
        <property type="protein sequence ID" value="XP_050509637.1"/>
        <property type="gene ID" value="LOC126886682"/>
    </dbReference>
    <dbReference type="GeneID" id="126886682"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028489" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="37"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="394" mass="43953" checksum="A7102F92BB41F2C3" modified="2025-10-08" version="1">MKRAIILAFAITTALAAISDAQSPIEQLAFANQKLTSNVYKEILKTKNGSIIFSPFSAETVLALTSEGAKGDTRSELLSVLHLPESHETIQQGFRELLPQLKINNRVAVLASANKIYVAKGVKLEDDFKKTAESIYASGLDQVDFLDSAKAANIINQWVESQTNKKIKNIIKPEHITGDTKMALINALYLSAEWSAVFPYYNTVIDKFYKTASEQIDQQTMAITEVFKHSENKELDTQFLEIPFQSNGLTFSVALPNKKDGISALENNIEKVFEPQPYTEVSVYLRLPKFTVETELNLKTILQSLGVRKIFKFDADLSGLAKNAKELYVSEVIQKAFIKVAESGVEAAAVTALLQDKIFGGYFPRDSIKFFADHPFIYFIKYNSVILFAGKYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ96</accession>
    <name>A0ABM5KJ96_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510285.1">
        <property type="nucleotide sequence ID" value="XM_050654328.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654328.1">
        <property type="protein sequence ID" value="XP_050510285.1"/>
        <property type="gene ID" value="LOC126887027"/>
    </dbReference>
    <dbReference type="GeneID" id="126887027"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="294" mass="33724" checksum="CE9459F575AB5762" modified="2025-10-08" version="1">MLVHRTQDNSLRTEWYRKPISSNRFINYYSEHPTRMKINLILGLKSIVTKISHPTYREESLKRLKRILMENSYPVGLLNKLIFSTATSPVSITLTENPNNKKQPTVKTASQVMNNSPTVDTLVPTTPQIFGSLPYIPILTPKLLKLFKGFENIKIATRNVKTIAHLYTKTKDPLTTKESSKVVYQIPCSDCDKVYIGETSRTLHSRIISHRSDINTNKSQACALADHSINLNHSFNFSQASILERVKNEQKRLFVEMTHIQKNKKCINRKSDIDKLSNIYCYILAYQQTFGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLU4</accession>
    <name>A0ABM5KLU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511170.1">
        <property type="nucleotide sequence ID" value="XM_050655213.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655213.1">
        <property type="protein sequence ID" value="XP_050511170.1"/>
        <property type="gene ID" value="LOC126887619"/>
    </dbReference>
    <dbReference type="GeneID" id="126887619"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF33">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="2">
        <location>
            <begin position="259"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="632" mass="72352" checksum="737AEF4E58C3487B" modified="2025-10-08" version="1">MGPKKPSGSEFKKIRNRKEQDNKKLASALGNWLKNENTSNNPGPSEPQIQDEEEDDEEVHGRETHTEDFCKSNMVLEDPTSHITPIEIDTNLEESSGNCSSHQIEYEDPRKWLTNFRLDTVRCTIVEKGPQMINLENHMFPCSDDGQRFSQKWVYKTLPNGENVKRQWLLYSQSKDVLFCFPCLLFSKDDKKDKSVFSNIEEGFNDWRHLHPCIVNHERSILHRDSYILWKELEIGLKTYKYVDAGHQKLIQAETDKWTNILKCFVDVILHCARNNLALRGGWDLIGDSNCGVFLSTLELISHYNPQLAKHIETVKHGKNVTSYFSPLIQNEVIDLLGSNVRSETLRKIKRAKYFSIMFDCTPDTAHLEQMSQVIRYVTTEDGKCSVEESFVDFIITHQKTGRGISQEILERLKTDDLDIQNCRGQGFDNGSNMAGKYESVQAHISQLNDLATFVPCAVHSLNLVGVHAAEVSVMMTTFFGKVLDFFKFFSSFTSRWEALLGCLNTTLKRHCDTRWSSRRQAVTSLKNGLTSVYKILISMTDRDNDWNADTVSGAMKVLKQIDFEFVSLLEMWSDILVSVDCTNKALQGKGTTLDVASSLLLGLAKKVEEMRKEGVFFVKNFWKMLKLRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPT9</accession>
    <name>A0ABM5KPT9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512196.1">
        <property type="nucleotide sequence ID" value="XM_050656239.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656239.1">
        <property type="protein sequence ID" value="XP_050512196.1"/>
        <property type="gene ID" value="LOC126888187"/>
    </dbReference>
    <dbReference type="GeneID" id="126888187"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="27017" checksum="C1394E4AD0C8DAFB" modified="2025-10-08" version="1">MDPLLYWFIFVTLICTLGILGSYLMFSIIRDSCFKRKKQKDTVMVIYEPDFHPACLSKLQYDKHDVEDLTRIERNFKTGFRRLSFQNEVFGKQFEGLLGEKRQSVDKESDVFVSTNTLDKSITSITEEDEESDDSFDRDTVSVDIEVSDEVREVLRIEKEAKKVEKEMNKFVGGTNDLQYYEINEKYIKLMISLCDMECSSIECRKHKNIVLNYIEQCQNQLKLKSLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPU7</accession>
    <name>A0ABM5KPU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512215.1">
        <property type="nucleotide sequence ID" value="XM_050656258.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656258.1">
        <property type="protein sequence ID" value="XP_050512215.1"/>
        <property type="gene ID" value="LOC126888204"/>
    </dbReference>
    <dbReference type="GeneID" id="126888204"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="641" mass="72279" checksum="712C7DAF5B61FE0E" modified="2025-10-08" version="1">MVRNYVRKTERQSWPVDSMEQAISAVIDGNTSLDKASSQYGVPKSTLARYVKKKRDSPEFRINKQSGKFTCIFNEQQELELANYVKNMEKRLFGLSMKDLRRLAYQLAHRNGIIHNFNQINQTAGQDWINGFLKRHPDLSIREPEATSGARAMGFNRVAVAQFQSLLKECIDKYKLNSDRIFNCDETGISVNPKGHSKIIATKGKRQVGTLTSSERGETVTVELCFSASGSYMAPMLIFPRKRKQQEFELGLPPGGWAEVSDSGWITTETFVSWFKKFIYFSKATKDAPVLLLFDDHSTHTKNIELIDLARDNGVILLCFPPHCSHRLQPLDVSLMRPISIYYEEEVRRWLRSNPGKVVTLFQIASLFGTAFINAATMKTALNGFKKTAIWPLDINAFTEDDFLLSAPTDIQIEIDDNLESRNANDLSTTNEVADEEQISQNDATTELIGTNSKTPASNGEHLPVLPQCSWMPDPVQIPSGKSNLTSFPTASPQHVLPIPKVEQNKKRTSRKKGKTAILTLSPYFEELKKAKEETKTKAAKKVERVKRKVSFSKDGSKATKEKVVKKKRVLLNKDLKDKTRDSDSSDTEDDAECLYCQDFYSTSNEGWVACSSCYSWGHNSCADVDSEDDESVFICELCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRF1</accession>
    <name>A0ABM5KRF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512763.1">
        <property type="nucleotide sequence ID" value="XM_050656806.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656806.1">
        <property type="protein sequence ID" value="XP_050512763.1"/>
        <property type="gene ID" value="LOC126888479"/>
    </dbReference>
    <dbReference type="GeneID" id="126888479"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23514" checksum="88C6832193682D65" modified="2025-10-08" version="1">MVSLDGEMIVKSNSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVAEMRMLRWMSGVTKKDKIRNEYIRGSLGVAPIDAKMREHRLRWFGHVQRRDVNHPIRRIVEVQIPGRSRRGRPKKTWGETIRQDMLVKGINIDMAQDRIVWRNAIKEADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRW5</accession>
    <name>A0ABM5KRW5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512931.1">
        <property type="nucleotide sequence ID" value="XM_050656974.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656974.1">
        <property type="protein sequence ID" value="XP_050512931.1"/>
        <property type="gene ID" value="LOC126888618"/>
    </dbReference>
    <dbReference type="GeneID" id="126888618"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
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    </dbReference>
    <dbReference type="Pfam" id="PF16012">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121990" checksum="43BF6AF523BC4995" modified="2025-10-08" version="1">MALELETKRRTVLRTAFTTAANVLNNLLSETVDTRPWQQISVQWELLQVKYNELCVVESAVFEAMIEKASEAELISEMEAKDRYSTRYYELKYKCEDRPSLVSSESSIKGKRSFKLPPIEFKKYSGDLIDWLPFWSQFKVVHDDQSIDLNDKIAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPFGSVSMHNVEESAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKCKSNNLVEKKNIKSPKQGTDQASATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKKCRARLNCILCCKSHVVLMCPDLPVNKIHTSTSSISRSEENITEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCLFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLWELNIIGITNPVEKLTREVAAKETKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKFKKSNLFESYNLIFNEWLNEGVIEIVNNPGENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGNEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEDKMDLRGGSKTQTGTYGEVTDKLRMAVVDRRHPEVKLNQEQAELVRTKLEEAVDKAPGGSQNPLQFLRTTFSAGILWIHCANEPTKSWLEGTVRELRDLWESADLKLIESKDLRRPIVLVHVPETGISEKCSGVAWASRMQGSIRQTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT65</accession>
    <name>A0ABM5KT65_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513384.1">
        <property type="nucleotide sequence ID" value="XM_050657427.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657427.1">
        <property type="protein sequence ID" value="XP_050513384.1"/>
        <property type="gene ID" value="LOC126889296"/>
    </dbReference>
    <dbReference type="GeneID" id="126889296"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="213" mass="24584" checksum="063A1D2CF6D486F9" modified="2025-10-08" version="1">MSCKMGSVCAMYGCNNYKQQKEHKSFFRMPKDKNVLKQWVAACQRQDLDLLFNEKEPEHLHKSYRVCSDHFEIECFRNKNLFSQGLFRGSVPTLNIHGIQNAPKRKIQDIVVTHESHKKIQLAEMPTDETDALTCAATTTTNDATTTNDATTMTNDASNNDLIENLQKENANLKVSIAMVKRKLKNKTSLLSKYKRRNEILKRKLQQFKKQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT85</accession>
    <name>A0ABM5KT85_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513400.1">
        <property type="nucleotide sequence ID" value="XM_050657443.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657443.1">
        <property type="protein sequence ID" value="XP_050513400.1"/>
        <property type="gene ID" value="LOC114341549"/>
    </dbReference>
    <dbReference type="GeneID" id="114341549"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022179">
        <property type="entry name" value="CFAP276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12494">
        <property type="entry name" value="DUF3695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="201" mass="23217" checksum="CC65DB7C7F23D8E1" modified="2025-10-08" version="1">MASIVRIRNRACVPVLTTEGTFLKPIADPEYLRKEVKCEYLPTFQRMHAHQTLASARRFVGFEPFSDLIPKDQLDFVLNASFNQTTEIFPDMLDIYCQPETRGIDTWRRLRNTREVTPDREQQASVEAPGGEKKKREVGRRGRPHKVVIPFRYNFDHKVLIGGVIEKKHPSNIKLMNSSHHSSQTNPGYSRQDSDGTVFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW23</accession>
    <name>A0ABM5KW23_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514386.1">
        <property type="nucleotide sequence ID" value="XM_050658429.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658429.1">
        <property type="protein sequence ID" value="XP_050514386.1"/>
        <property type="gene ID" value="LOC114340447"/>
    </dbReference>
    <dbReference type="GeneID" id="114340447"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="459" mass="51374" checksum="D7ADD645C2F97FCF" modified="2025-10-08" version="1">MVSNISYFNRKCHRKPVDFSINSASHGFTSGALTGWTSPFMVKIVEDTENYNVREDQAALFAILNVVGLIILTPFFPPFIDIIGRKKAIVLSSVPFIISWLTKALFTNLWALYIARLLVGLGDALIMCAYPMYFGEVATPKVRGIWGNAFFILVIFGTFVINVVGIYCSVKLTSYIFLAFEVLFLILSLFIPESPYFFIAKDQLSSAKLSLMKLRQNNDVDVEFKLMQDDLNRQLSESGTWKDLFVIDVNRKALMIATFLRFAQIVSGLWVFGSYTQFVFQKVVSDISAETSTIIYTGLNFVIYSAAIYSSDKFGRRKSLLTSLAGTGIVFLLVGVYFLIEKFLPGVNLQPVNWFPLAGLIIFLLVSSFGVGPIPALMQGELFSASIKSKGISMVVVAYGIIKICTNSAFYYLYVYTGLSGPFLFFAVSNFISLIITYFIVPETKGKTLEEIQQHLKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZB3</accession>
    <name>A0ABM5KZB3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dynamin GTPase</fullName>
            <ecNumber evidence="1">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050515529.1">
        <property type="nucleotide sequence ID" value="XM_050659572.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659572.1">
        <property type="protein sequence ID" value="XP_050515529.1"/>
        <property type="gene ID" value="LOC126890552"/>
    </dbReference>
    <dbReference type="GeneID" id="126890552"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="12">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="520"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="11">
        <location>
            <begin position="657"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="757"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="798"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="901" mass="100814" checksum="58A3949F40A6A854" modified="2025-10-08" version="1">MAGNLGMEQLIPIVNKLQDAFTQLGVHMTLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINAISEHAEFLHCKGKKFVDFNEVRLEIEAETDRVTGSNKGISNIPINLRVYSPNVLNLTLIDLPGLTKVPIGDQPIDIEQQIRGMIMQFIKRESCLILAVTPANTDLANSDALKLAKEVDPQGIRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIDGRKDINAALNAEKKFFFSHPSYRHIAERLGTPYLQRVLNQQLTNHIRDTLPSLRDKLQKQLLQLEKDVDQFKHFRPDDPSIKTKAMLQMIQQLQVDFDRTIEGSGSAQINTNELSGGAKINRLFHERFPFEIVKMEFDEKELRREIAFAIRNIHGIRVGLFTPDMAFEAIVKKQISRLKEPSLKCVDLVVQELSNVVRMCSDRMARYPRLREEVERIVTTHIRSREQNCKEQLCLLIDCELAYMNTNHEDFIGFANAQSQSESATAKGTRGTLGNQVIRKGYMCIHNLGIMKGGSRDYWFVLTSESISWYKDEEEREKKYMLPLDGLKLRDIEQSFMSRRHMFAIFNPDGRNVYKDYKQLELSCETLDEVDSWKASFLRAGVYPEKQTETLNGEDSSGESVTSSMDPQLERQVETIRNLVDSYMRIVTKTTRDLVPKTIMYMIINHTKDFINGELLAHIYASGDQSQMMEEAPEEAQKREEMLRMYHACKEALNIIGDVSMATVSTPVPPPVKNDWLASGLENPRLSPPSPGGPRKTTPQMSAVGSSGSLGSRAPPPPPSSGRPAPAIPNRPGGGAPPMPPGRPQGQALPAPLIPTRVGGQQGQGGIQVPQQVQMAVGRAVTNAAINELSNAFKFHNRPVPNVPPRIPDRPHPGRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L160</accession>
    <name>A0ABM5L160_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503622.1">
        <property type="nucleotide sequence ID" value="XM_050647665.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507153.1">
        <property type="nucleotide sequence ID" value="XM_050651196.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508884.1">
        <property type="nucleotide sequence ID" value="XM_050652927.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516171.1">
        <property type="nucleotide sequence ID" value="XM_050660214.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519004.1">
        <property type="nucleotide sequence ID" value="XM_050663047.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647665.1">
        <property type="protein sequence ID" value="XP_050503622.1"/>
        <property type="gene ID" value="LOC126882688"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651196.1">
        <property type="protein sequence ID" value="XP_050507153.1"/>
        <property type="gene ID" value="LOC126884887"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652927.1">
        <property type="protein sequence ID" value="XP_050508884.1"/>
        <property type="gene ID" value="LOC126886083"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660214.1">
        <property type="protein sequence ID" value="XP_050516171.1"/>
        <property type="gene ID" value="LOC126891036"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663047.1">
        <property type="protein sequence ID" value="XP_050519004.1"/>
        <property type="gene ID" value="LOC126893102"/>
    </dbReference>
    <dbReference type="GeneID" id="126882688"/>
    <dbReference type="GeneID" id="126884887"/>
    <dbReference type="GeneID" id="126886083"/>
    <dbReference type="GeneID" id="126891036"/>
    <dbReference type="GeneID" id="126893102"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="666" mass="77449" checksum="F20CBF6E5C33B5E7" modified="2025-10-08" version="1">MNKTNSKKPKGKNNDDQRQKDNDDALISKIENREEQSQDGTIDEDELRKFERELLQRHDQQPKLNRSGAIKHSTLVGEEINTREEEEKEEEEKEEEDPSVKILEAKAFTESHDEKTEEERGGTWEDIEESVLTAFLFDEEDRREMQQMKKRKGDSLEINEKFKKEKLEESKKYPEETDREKVQRKMKQILDILNTEGPIEDERIRMKKLIGEINSMQNRKISPNQTTQGEEKNIRCEQCKIKIEQERQRKETEKIIGIVNKGGDIDTFSQIHEKKWEDKVFEKTKWEHGGLQETIEKKECIIITKNEIKDGGVEGVIRTLREEVAEIIEECKVGDIEYIENVKKSSMANQRRQWYTYVTKVGEQGMYEMAVKAINIIKKREKPPETVRVIVNNEINKEDVRKALEFVGRKENIVWEIVIRGKEMDKGERHEQEEALLIKTGGKSYTDVLKEMNQKIDIGKIGLKVNRLKKTEGGDILVKLKGKGAAEKLKKEMDSKITGMSMAVRKKENYFSITAIDPGFTEEQLISAITTYTGIPEDEIDVKTLRINRHGEQVATIAVRPSKAEELRRYRTIVIGWVICPIMERHTPVRCYKCLHYGHSTYECTGESRVACCYNCFKNGHTAVQCSSTAYCLTCKEEGHRMDRMTCPAYRAWVYGRGGEREPIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1X1</accession>
    <name>A0ABM5L1X1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516437.1">
        <property type="nucleotide sequence ID" value="XM_050660480.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660480.1">
        <property type="protein sequence ID" value="XP_050516437.1"/>
        <property type="gene ID" value="LOC126891298"/>
    </dbReference>
    <dbReference type="GeneID" id="126891298"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="93"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="236" mass="26739" checksum="2FE91D5625E325FB" modified="2025-10-08" version="1">MDSSESEEDLILLVALADEEDQRFLATGESFSTIGYSYHVGFSTVSTIINEVCEAIRKRLQPIYLPEPTTEIWQKSAEDFLNMWQFPNCIASLDGKHVTIKCPGKTGSNHFCYLKKFSIVLMAIVDANYKFIFIDVGGYGKNSDGGIFENSNMGQRFEEGLMNVPEDKNLPGQVEPCPHVLIGDEAFALKSFLMRPFPYKQSRSDRRKENYNTRLCRARRVVENAFGINSKMASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1X2</accession>
    <name>A0ABM5L1X2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516169.1">
        <property type="nucleotide sequence ID" value="XM_050660212.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516439.1">
        <property type="nucleotide sequence ID" value="XM_050660482.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660212.1">
        <property type="protein sequence ID" value="XP_050516169.1"/>
        <property type="gene ID" value="LOC126891033"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660482.1">
        <property type="protein sequence ID" value="XP_050516439.1"/>
        <property type="gene ID" value="LOC126891303"/>
    </dbReference>
    <dbReference type="GeneID" id="126891033"/>
    <dbReference type="GeneID" id="126891303"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="88962" checksum="6AA50933D53C22B5" modified="2025-10-08" version="1">MIIPNWNKRILKFSNFKNKIKVSFVIYADIECLLLKYSDPTIPTANMRKIQHHVPYSVAFLLKCSYDDSLTQFKIYTGEDCISWFVKELGLISKKLDDIYSNVVPMTPLTNLEENQFLNAELCYICTQPFSDDDIKCKDHCHRTGTYRGPSHQCCNLQLRETFMIPIVFHNLGYDSHFLIKHLNTDIEGNFQILPLNKERYISFTKFVQGTKCSLRFIDSYRFMSESIDKLASYLTTSQNKILKSFFPNEIQFNLLTRKGVFPYEYLDSWEKLKDENLPPKNAFYSTLTKTHISDDDYNHACNIWTEFHNNTLKDFSEIYLTTDVLLLGDIVENFRETSLKTYGLDPLHYYTAPGLSFDACLKITGVEIELLDDIDKVMFIERGLRGGISQVSNRYGKANNKYMSKDYNEQDRDSYLIYWDFVNLYGTIMCFSLPYGGFEWIDPNVMPDITTVDKNSDIGYILECDIIYSKELFNIHKDLPLCPEHLIPPKSKSKVTKLLTTLFDKKHYIIHYRALQQAVTLGLKLDKIYRVLKFNQAPWVKKYVDLNTELRKKSKNEFESNNYKMMTNSFFGKTCENVRKYKDCKLLSKWEGRYGVRNYISKPNFHSLSIINENLVVVEMKRTQITFNKPLFIGFSILDLSKVWLYDFHYNYTKNKFGDNAKLLYCDTDSLIYHIFDENVYEHMRADINKFDTSNFSVNNAYNMPLCNKKVLGLMKDENGGRIMTEFVGLRSKMYALKVLNEKEEYSIKKAKGIKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2N9</accession>
    <name>A0ABM5L2N9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050516706.1">
        <property type="nucleotide sequence ID" value="XM_050660749.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660749.1">
        <property type="protein sequence ID" value="XP_050516706.1"/>
        <property type="gene ID" value="LOC126891573"/>
    </dbReference>
    <dbReference type="GeneID" id="126891573"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17628" checksum="6D8F341D7423FF7E" modified="2025-10-08" version="1">MNISPNRPLADENEEIPCVLIGDEAFTLSPYLMRPFPYRQARNDNSKERFNYHLCRAPRVVENTFGILAHKWRLFFRPLEVKVQTATKLVKAACLLHNLLRTRNTDEQFLHLQENSNIPLPVVDNLAVDGRRAVNEAFEIREKFVTYFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4V4</accession>
    <name>A0ABM5L4V4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517465.1">
        <property type="nucleotide sequence ID" value="XM_050661508.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661508.1">
        <property type="protein sequence ID" value="XP_050517465.1"/>
        <property type="gene ID" value="LOC126892079"/>
    </dbReference>
    <dbReference type="GeneID" id="126892079"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="135" mass="15305" checksum="540913A464919507" modified="2025-10-08" version="1">MCNKFPSLDTLFESMCYLLGKRLQEVGLLGAQPSNNFLMKAAYQLCPHHVSHYLGMDIHDTPTVTRNVQIEPGMIITIEPGIYVNENNKLLPKQYRGIGIRIEDDILITENGPVVLSRKCPKHIDEIERIASENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L653</accession>
    <name>A0ABM5L653_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517915.1">
        <property type="nucleotide sequence ID" value="XM_050661958.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661958.1">
        <property type="protein sequence ID" value="XP_050517915.1"/>
        <property type="gene ID" value="LOC126892430"/>
    </dbReference>
    <dbReference type="GeneID" id="126892430"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="378" mass="43695" checksum="1C6C72DD45B93BB2" modified="2025-10-08" version="1">MENFIEEVFFGDDEIIPAVINEVIDLAQPPQNIIPEERQQVTRNEQYYEYTIPRYTNDDFREHFRMSRVTFERLFNCIRAVHHIEDRLVPLEKKLLFTVWVISKPESFLAAGDRFGLAKSSAHKIFYQIVDELGQITNQYIRWPNMQKIQQTANVFELRSRGIPGVVGAIDGCHIPIKQPVRNANDFYNRKGFHSIILQGVCDENGVFIDVNIGRPGRMHDARVFRLSEIYEYLTRENSILPANLHLIADSAYPLLLNLMKPFQDNGHLPEEHVVYNTKLSSIRSTIERAFGLLKCKFRRLKYLDVNNSQIASRIVLAACVLHNFILLQGNAALDEYDIVNAAPNENMIEGVHENDLLVNDASNKRREIVQICNRENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6K4</accession>
    <name>A0ABM5L6K4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050518073.1">
        <property type="nucleotide sequence ID" value="XM_050662116.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662116.1">
        <property type="protein sequence ID" value="XP_050518073.1"/>
        <property type="gene ID" value="LOC126892551"/>
    </dbReference>
    <dbReference type="GeneID" id="126892551"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="693" mass="77022" checksum="559F34A775E89290" modified="2025-10-08" version="1">MDSYPDVQEHESCAKRIKLDLDESNLGELCKGEGFSCFSTSSTGPIDITEGISADCDSGYEASNLESVPTPLHTSPRTDPGDIQETMSSISESFMQTPTHADQQDTSQDSVIEDDDDNASTVSELSGLSDLSGQDWKPMAGSMIWIQQQMQKGVNPREILSELGVDSQIPEYVDDIAIWKLIINMLSEPPRRNKLRHINTLDDVVRLLKGAQNIIVLTGAGVSVSCGIPDFRSRDGIYSRLAIDFPNLPDPQAMFDISYFSQDPRPFFKFARDIYPGKFQPSPCHRFIKLLEKQKKLLRNYTQNIDTLEKEAKIDKVIECHGSFATATCTKCGHKVTAEKIRDHVLAQKIPLCEVCHPGQECSVSTDDVRASQANTNYRELVESGIMKPDIVFFGEGLPDTFHEAMIEDKSECDLLLVIGSSLKVRPVALIPSSLPSQVPQILINREPLPHCHFDVELLGDCDVIINHLCRLLGNHWEEGIYSSQTLQHAETLLPLENPLLPELDKQPIPSIDFSYSHQSVSSHCICKSTNSSSLSADVTTETQCLCFTYKSINDSELESKSGKERHMSIDSAKDSGIGENSNFTDKYESDENGEEKSATSFCLEICNDSSTSSEGFRKSSSDLRGYWQPKVKKSLADRLPENSFHLIPPSRYIFPGAEVFYDPDEKLHYEGDTSNSDDSESESECGSQNCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8X8</accession>
    <name>A0ABM5L8X8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518896.1">
        <property type="nucleotide sequence ID" value="XM_050662939.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662939.1">
        <property type="protein sequence ID" value="XP_050518896.1"/>
        <property type="gene ID" value="LOC126893003"/>
    </dbReference>
    <dbReference type="GeneID" id="126893003"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="416"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="499" mass="56942" checksum="71D8836DDD49C45C" modified="2025-10-08" version="1">MFDETSDLSHKEQITLVVRYLWKDAVREDFITFIDAYNAAADVNGKECKENKLSGKTLGEIVLRNVKELGLDLSYCVGIGTDGASVMTSEESGSVTKIQSEAVSAKRLPCYNHALNNSISKSNKIRSINNAVGIMKEVIHFYNQSAKRNAVLTEHVGRQLVSLCETRWVDRHDAVILFFCALPEIVDSFTEISEWKESESAKKAVLYINSITSTEFIFSCVCLVDILKRTLPLSKLLQKPNLDLNKASNAVTDTLTCLKDRRRNCDDHFTELYLEALTTSEKLGVQLKMPRVVKSQRHRENYEAETVMEYYRMSMYIPLLDNVITDLQTRFSEENLLCFDLNLLMPANMLNTNVSEKCLELNVRLQKVCQNFKTLLPSDSEVVLEGELNIWRAKWSREKEEGMKIPNCAIEVLKCCDGDMFPTVRTLLQILITLPVSVASAERSFSSLKLVKSWLRTRMVEERLNGLCLLYIHRDIEVNVENVIERYAKGGKRRLDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA28</accession>
    <name>A0ABM5LA28_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519290.1">
        <property type="nucleotide sequence ID" value="XM_050663333.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663333.1">
        <property type="protein sequence ID" value="XP_050519290.1"/>
        <property type="gene ID" value="LOC114346485"/>
    </dbReference>
    <dbReference type="GeneID" id="114346485"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06759">
        <property type="entry name" value="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="400" mass="45574" checksum="230AE2E58B587C2E" modified="2025-10-08" version="1">MCSKALFNDFSEIGNFISDLNGSISQKWKRLRKCCASLRGNNVHNSETSKSTLLESTTPNILVSTPHTTSSLRIPNNSKRSSVQDVLRAKLSQIHVGLRKRRALSVQEFFHNPNQEKPNPTFYVPSPCPNPVNAQTRRPRSRQRAVNSLSFTPTQSREYIKCNSGEWHPLPYEPPPDYDLEEKPPNRRWSVVTFSKESHKPKPKIENVNIKIPKTKLNKQYDRARSQSPSWKKEQFKVYNGENRRVANSKSHYELIGARDKPERGRDRGSEHQNSIEELEEIEEEESKFCTLPRGGNTFTIRQVIFQKGSDFKPLGFSIVGGRDSPKGSMGIYVKTIFPNGQAADNGTLKEGDEILAVNSKPLHGCSHKEAINVFKQIRQGSVLLHIGRRITKKHRDKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2I9</accession>
    <name>A0A6P7F2I9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial ribonuclease P catalytic subunit</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial ribonuclease P protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114325279</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028129097.1">
        <property type="nucleotide sequence ID" value="XM_028273296.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502512.1">
        <property type="nucleotide sequence ID" value="XM_050646555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2I9"/>
    <dbReference type="FunCoup" id="A0A6P7F2I9">
        <property type="interactions" value="1339"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646555.1">
        <property type="protein sequence ID" value="XP_050502512.1"/>
        <property type="gene ID" value="LOC114325279"/>
    </dbReference>
    <dbReference type="GeneID" id="114325279"/>
    <dbReference type="KEGG" id="dvv:114325279"/>
    <dbReference type="CTD" id="31568"/>
    <dbReference type="InParanoid" id="A0A6P7F2I9"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030678">
        <property type="term" value="C:mitochondrial ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18718">
        <property type="entry name" value="PIN_PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033495">
        <property type="entry name" value="MRPP3_PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="17">
        <location>
            <begin position="281"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028129097.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="60009" checksum="99894B0AF3865679" modified="2020-12-02" version="1">MLPRYFNKLCIRNYSFKKTILVQQKQKSHNIVADIIEENKITNSQDWKKIRDTLLGIKNNTGHYSKNNIDAVILEYCIKKNKHELGTNYINFLKEENIKPNLGFIGKYFKFLYNINKDICHKEGKKCPKDQEEIVLKMYNDLRIEYPLLDSVSLENIIPALSLTSEWKKCVDLLKEIHFSATPTGEVYSSVAAAAFLNKQENLSWDLLREVIEFQKQIKSVAFLSYLTSLKKLKKRENILIKLKQMFVFLKENEIICDQVVAEEIGTYVKKLGLTGSLTYINQKGFCKNCQQQLQKFELSNEEFEDLKNKILNKVILGKDIFVKTNPLELDKFTAFVSNQDRFDVVLDGLNIAYSVGTKQPPSVFAALLAAVVSHFREQNKKVLVVGRQHMTRWPQQSWNYINENATVFLAQNISQDDPYLLYCAINSGKDTIIVTSDLMRGHRFRLETAKHRLLFNRWLTQRQYQLLKVVGSGKPIFKHPLPYSITTQENGHCWHIPFKKEVIKDNESSVGWLCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2M4</accession>
    <name>A0A6P7F2M4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114324196</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028127765.1">
        <property type="nucleotide sequence ID" value="XM_028271964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2M4"/>
    <dbReference type="FunCoup" id="A0A6P7F2M4">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271964.1">
        <property type="protein sequence ID" value="XP_028127765.1"/>
        <property type="gene ID" value="LOC114324196"/>
    </dbReference>
    <dbReference type="GeneID" id="114324196"/>
    <dbReference type="KEGG" id="dvv:114324196"/>
    <dbReference type="InParanoid" id="A0A6P7F2M4"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028127765.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="33023" checksum="C18A91A3D92C9EA2" modified="2020-12-02" version="1">MAPKIEKLCGNFKLAEAPHWDESSQMLYFVDINGYTINRYDPKTKKHNSAFVGKNVSVIIPVKGKKDQFVISLERELMLVTWDGLSQKPSKMEKILEVDQNTKNVFNDGKCDPSGKLWIGTMGGPPVVIADIPLGMGTLYSIQNKKASPHCSNIGIANGIAFNTDLKKMYYIDSRTGTVDQYDWDMATGKIANGKPIFTAKKNDMDGMVFDGMTIDTDGNLYVAVWGSRIIKIDPRKPETLLETIMMPAKIISSVCFGGANLDELYVTSGQVGITPGPDDGAVFKVTGLTTKGYAEVSMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4K6</accession>
    <name>A0A6P7F4K6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114326251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114326251</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130366.1">
        <property type="nucleotide sequence ID" value="XM_028274565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4K6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274565.2">
        <property type="protein sequence ID" value="XP_028130366.1"/>
        <property type="gene ID" value="LOC114326251"/>
    </dbReference>
    <dbReference type="GeneID" id="114326251"/>
    <dbReference type="KEGG" id="dvv:114326251"/>
    <dbReference type="InParanoid" id="A0A6P7F4K6"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028130366.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="45249" checksum="DF858393A9719F23" modified="2020-12-02" version="1">MVRCLICLFRFSKLKKLYEHYFKSHRKVEIIKKFIEENILLPSVLKKHRKKNVHNIQKKRTKKCCQKFTKLNIEDLPTEPVVLSENIRIFCGDEEIIRIGDNKHSIKLSFEDDGNQNKDICCLTLKEIGSLNEAKLPRALKRKNKKENACKKKIKRKKVSKKKKQNIEINITKVKEPSLPSKPIAAFEANCFDSRQYPKSELRLLTSDTESCSDTSKNSFVPPEDTKLFCLKCGSGYKTQQELSEHMYIHEPFCRLCNTWFPDEFTFKQHMQLHKIRIFACHVCSAEFPFKELLFKHFECHMEDRLYEDVIDMEEDYKTLQYSFVNTNYNTSINSILCYLKDRPDFYYCNYKIMKTICDFCYKEVSVNEYEQHLQIFHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4T9</accession>
    <name>A0A6P7F4T9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114324810 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114324810</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128480.1">
        <property type="nucleotide sequence ID" value="XM_028272679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4T9"/>
    <dbReference type="FunCoup" id="A0A6P7F4T9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272679.2">
        <property type="protein sequence ID" value="XP_028128480.1"/>
        <property type="gene ID" value="LOC114324810"/>
    </dbReference>
    <dbReference type="GeneID" id="114324810"/>
    <dbReference type="KEGG" id="dvv:114324810"/>
    <dbReference type="InParanoid" id="A0A6P7F4T9"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF120">
        <property type="entry name" value="MUCIN-5AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028175057" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="798"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="950"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028128480.1"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121120" checksum="741E30026BE774A3" modified="2020-12-02" version="1">MFGIVNARMKNPKNLSWCLLFLCTLFECSLAQIVGTHTQFAPNADRTSRLSPQQQGQILSDIQQHQHRFDLSQNRQNFQPQHFQSSQNLQAAQRFQGSFVNQQQLVSQSPLSQNTQENFARNEFLNTLPLLKSIPSNVVPTPQQTFQQISPPTAQTASSQVVFPSQQPTDTSKIIQHHTQTNFLPARQVLSFGPQFVQPRPTPDPLEVIDQQIKQLDPEKNKQRIKELKEKQIIIEKHNQFVERQYEKALKKAQEEHQDFIDKQRNQKKQLYQRLYKTSPSEPRSSLTAPRLVYPEEVNLFEQAVKQYYIQYPTTTTTTTTTPKPTTTKKIEKPSLGLSFLPTALPQSKVKTIQSLDDLDQLQKEYKSQRIRKDDLLEQLRLAIGRNSEDENGKVLSSREISLANGKKIQLIAADDQTNVPRGKEEEITLPDGKKVTVIRPDDLVNKSDEEVTLPSGHQVKIIRTTDPNAIPNLSKGFGDISQEITLPDGQKAQLIKARNPSGSPTPIEEIVLPNGQKVELIKTSDPSLVPDGVKVEPGSDLEKLVFSRTTTSTERPPKEILDELTKSVPSSNFELLKTGASGGLESIGKNLPNQKKVTFVLLEEQSDGTLKVQGVKGNDKDKTVDVDAILSKIKRGEIKLPDNLKQPTKTTTKKPEVISTTLKTNYSPTLKPVFATITPNSFATEEPNIFQHTQNYENEEGDVPALQTNIGTKIIASSTPATYFPSGTTSEQKKSTRTPHILNSANDLLNQASTVQSAPNKNLLAPIPTEITFQQSVSPVNLFPIQETFSSPENQKHLLELPEILKKNNLFAMSKFLRQSGLDTILNETGPYTVFVPTDKAFRTLLIQLGGPEKAEEKFKENPRLLSGLLLHHVIPGAFKISSLQDEMTGVSLAGTQLRVNQYSMHDKEWNDIKITTINGAKIQEESQDIDIPQGVAHAIDRVMFPLPVGDIVQTLQSDRERRFTSFLRAIFASGLDEMLQGSKIFTLLAPTEKAFAGLSVEDLSKLVTDKVLARELVLRHLIAGTLYTNGMRYYQIKDSLLQDKQITFSKQSGKVKVNNNLLTTQNIPATNGVIHAIDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F836</accession>
    <name>A0A6P7F836_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macoilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Transmembrane protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114327513</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of neuronal activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Rough endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131954.1">
        <property type="nucleotide sequence ID" value="XM_028276153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F836"/>
    <dbReference type="FunCoup" id="A0A6P7F836">
        <property type="interactions" value="1370"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276153.2">
        <property type="protein sequence ID" value="XP_028131954.1"/>
        <property type="gene ID" value="LOC114327513"/>
    </dbReference>
    <dbReference type="GeneID" id="114327513"/>
    <dbReference type="KEGG" id="dvv:114327513"/>
    <dbReference type="InParanoid" id="A0A6P7F836"/>
    <dbReference type="OrthoDB" id="10071111at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="MACOILIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="68"/>
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            <end position="114"/>
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            <begin position="120"/>
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        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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            <dbReference type="EnsemblMetazoa" id="XP_028131954.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028131954.1"/>
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    </evidence>
    <sequence length="622" mass="71309" checksum="C0D294B4F26175DF" modified="2020-12-02" version="1">MKRRNVEIAKMRRPVKKNKITEGFYGSTLLYLKFVILWALVIMADFILEFRFEFLWPFYLLLRSVYDSFKYQGLAFSIFFVCVALTSDMLCYFFIPVNWLFFLASTYVWVQYVWHTDKGICAPTIVLWVLFVYLEAAVRLRDIKHMPGHLDLCRPFAAHCIGYPVVTLGFAFKSYVGFRMRQRKQQVVAKENQFYMQLMQQALPVETCANAQEQIEPPPNAVVPVQPVLNNNKLQNSTKSHEKNGHIPNGAIANGVHNTHTTKSHHRKSVEKCKDQDQHGNDHTSKHSDRHIDRQKVNHAHSNGSLVNSSIEEASSQESETRPTRRREKREQDKDREATEYLQRLETDVKKLRSDLHTSRASEQELRLQVASLTTSEKVSKGEICSLQRDVEDVQQRLQSALSTKSSDKQTISNLERRLAEERRLRSNLESQLNQERKSRKQEEARAAQVAAQQSSRGECTETCKVRRRELESEISELRASKHWQEDRLQALERENSAFSEQVRDTELLMSALSALQEKNSHLENSLSAENRIKLDLFSALGEAKRQLEIRESANRAQEKEIEELKSKIAQVLAVMPTDSFGSPAPGGNMSRVRLAESPPSNLDPNATAYTPKSSLVASTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCU7</accession>
    <name>A0A6P7FCU7_DIAVI</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="primary">LOC114326940</name>
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        <lineage>
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            <tissue evidence="4">Whole insect</tissue>
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        <scope>IDENTIFICATION</scope>
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            <begin position="23"/>
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    </feature>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131215.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028131215.1"/>
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    </evidence>
    <sequence length="136" mass="15818" checksum="EB93F51B5AFFDE58" modified="2020-12-02" version="1">MNISVGVSVLFLLTLYFKNITSHELEKSKEDESKYSAPVWFGPRVGRKKRGFLDEEYKNIDKQELETLLELIKKNPWTIMLFSNGKGRLLNFNPKESSIEGLNEDEITEIVQRSMFAPRLGRSAFFPRLGRDNEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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        <name evidence="5" type="primary">LOC114327013</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <tissue evidence="5">Whole insect</tissue>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <end position="186"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028131308.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="29232" checksum="C2AF8B56B6E6736D" modified="2020-12-02" version="1">MKVYVLFIICAITLLQFAASDRASDMKARIDQLNRQNQQGSYGNQPTTNKYGQNGSYNNGYNNGQRYPNSNQIGQVNRNASRDLYPNLPQNNNGNPNWANPNYNPNGGSYGNNNNNNNNRYPATGYNNGQSNPNDPYNRNNGYNSNQNQPGSQGYNSGSNGYNSGTKYPYNQGQNGANQGYHNSGSPGYPITGSMGYPNTGSQGYPNTGSQGYQNTGSQGYHNTGSPGYSNTGSQGYPITGSQGYPNTGYNQGNQGYPNSYNSGNQGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIV1</accession>
    <name>A0A6P7FIV1_DIAVI</name>
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        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
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        <name evidence="11" type="primary">LOC114328347</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS9 family.</text>
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        <property type="nucleotide sequence ID" value="XM_028277177.1"/>
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    <dbReference type="FunCoup" id="A0A6P7FIV1">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277177.2">
        <property type="protein sequence ID" value="XP_028132978.1"/>
        <property type="gene ID" value="LOC114328347"/>
    </dbReference>
    <dbReference type="GeneID" id="114328347"/>
    <dbReference type="KEGG" id="dvv:114328347"/>
    <dbReference type="CTD" id="64965"/>
    <dbReference type="InParanoid" id="A0A6P7FIV1"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000035">
        <property type="entry name" value="28S ribosomal protein S9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028132978.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="45108" checksum="5B7078A6187AA670" modified="2020-12-02" version="1">MFLPKINRIIDPFKSLAIQKNIAATVNGAQTMSTTVAPSEQKTEKKPISKAMKAYLERAKEHDEFMKRQKEEFLIGKRHLANMMGEDPETFTQEDVDNAIQYLFPSGLFEPKARPHMKPPEEIFPQRKAAEFDETGRPYHFLFYTGKPSYYQVLHDLTSHINDLIKFEDTMIRKNLQPDPNLTFSMSGFQWLDKQSLETKFVETLKEKDYEYFITSLERLSAMPYSYKVKDFILEYANPLINKVQSQETPKANIDKDGRQFVTIYECMRKRSRGDVTIRLPGTGKISINGEDITYFKEDQPREQLLFPLIFTSMLNKVDVECNVEGSGESAQAGALRWGIATGLRSFVDEEMVEKMRLAGLLTKDFRTRERKKPGQWGARRKFTWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FL70</accession>
    <name>A0A6P7FL70_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Polycomb protein Sfmbt isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114328923</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133713.1">
        <property type="nucleotide sequence ID" value="XM_028277912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FL70"/>
    <dbReference type="FunCoup" id="A0A6P7FL70">
        <property type="interactions" value="1964"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277912.2">
        <property type="protein sequence ID" value="XP_028133713.1"/>
        <property type="gene ID" value="LOC114328923"/>
    </dbReference>
    <dbReference type="GeneID" id="114328923"/>
    <dbReference type="KEGG" id="dvv:114328923"/>
    <dbReference type="CTD" id="34709"/>
    <dbReference type="InParanoid" id="A0A6P7FL70"/>
    <dbReference type="OrthoDB" id="5800688at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20100">
        <property type="entry name" value="MBT_dSfmbt-like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20119">
        <property type="entry name" value="MBT_dSfmbt_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047358">
        <property type="entry name" value="MBT_dSfmbt_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012313">
        <property type="entry name" value="Znf_FCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038603">
        <property type="entry name" value="Znf_FCS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF104">
        <property type="entry name" value="POLYCOMB PROTEIN SFMBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21319">
        <property type="entry name" value="zf-FCS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51024">
        <property type="entry name" value="ZF_FCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FCS-type" evidence="15">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="257"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="373"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="475"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="12">
        <location>
            <begin position="592"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="849"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="701"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="780"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028133713.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="103882" checksum="B9A8A7F8CB702281" modified="2020-12-02" version="1">MNVYSTMPGVAEMGMVWMGSGQTAGDMSMGELMPNDNSDILLDHDNIYYTPSNHSMSNQSMDDIHTGHSSHMDTMENYDMMHYLDIKNESNDSSYMDDDSPNPVYMITTSTQTLPSQKKIKPIKHPGLVLKTPIAYHSNTDPSVIPIQKDGIAVCEKCGAIGVKHAFYTRERRFCSMACARGYSGLIPEPLPQQYPSTPDSKHHFAKYRFSMKLEDDFADSYIDDTIPQLSPLPELPPIDDSLPLIRRKPAELANSFDWDSMFSEPYFVAAPVTCFKHAPMADIWDNIMVGMKVEIENTDCDNVSEAFADSFWVATVVRIVGYKAQLRYEGFGENDSKDFWVSLCSNQVHPVGWCATRGKPLIPPKTIENKYSDWKDFLRKRLTGARTLPSNFSNKASDSLKSRFECGLNLEVVDKDRISQVKLAIVHKIVGKRLNVKYYDMPPEDDGFWCHEDSPLLHPVGWAKKVNHHLVAPINYLERVNDGIFDDDDATEDLFNPYQVGFMENSVSGFCIGMKLEAIDPLNLSSISVATVTDVLNYGYIMIRIDTYDSDVTGADWFCYHVKSPCIFPVGFCEKHNIPLTPPKGYDVLTFNWKSYLLQTGSSPALPSLFKTFIPLHGFQPGMKIEAADLMAPRLLCIATIAKVTGRLLKVHFDGWEDEYDQWLDCESPDIYPVGWCQSVGYKLEGPPAFAKQLLPVVKTQKAKKRGRKKKKDTASKSQQHAATSTNSETSSVFEAPEPLERMEQSETSEVGGIEEPEEMPTETDLATIIPDIESLASTEDINDSHGPEAGQEPAGPDQSLPISSEVVDDSFNPCVNSSTPSSPKVIPRLIDNSGSTSERSELCPKEWSSSDIVQFLRVNDCANYSDAFSKQNIDGKKLLDLSKEDVIDITGGKVGPSLKIYDLVQQLKLKMNLSQVRHSKANIKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVP8</accession>
    <name>A0A6P7FVP8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Nuclear hormone receptor HR96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114333147</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138812.1">
        <property type="nucleotide sequence ID" value="XM_028283011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVP8"/>
    <dbReference type="FunCoup" id="A0A6P7FVP8">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283011.2">
        <property type="protein sequence ID" value="XP_028138812.1"/>
        <property type="gene ID" value="LOC114333147"/>
    </dbReference>
    <dbReference type="GeneID" id="114333147"/>
    <dbReference type="KEGG" id="dvv:114333147"/>
    <dbReference type="CTD" id="42993"/>
    <dbReference type="InParanoid" id="A0A6P7FVP8"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000035">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
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    </dbReference>
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        <property type="entry name" value="zf-C4"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="251"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028138812.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60050" checksum="A6A6ACBAB089DE2A" modified="2020-12-02" version="1">MKGAKVVDLKVCGVCGDKALGYNFNAITCESCKAFFRRNALLQKPLKCPFNNQCDITTLTRRFCQKCRLDKCLSIGMCKDLIMSEQDKVAKRQKIEENRAKRENMGKQKQNFKRVKREYVEPDSQSFENQSNTDSDSNYTSADVTSPAQVTSDYTNLSIDSLEDSESPIDRYNSSDDYTNTNNNTPEPKKEEHVSQSKLADITCSNSNISSSIPRTNFTSDISNHNSPDSCNTSVDISQVIHDVHSVRSEENNPIESVLCEAIKLEFQAFSSIPQSPSNSRELNDAERAKLNELIVANKAFLMPIDEEFENLAGVTKFENSRHKMDTTALLDVINLTTIYVRRLIKMAKKIGAFRNMCQEDQVALLKGGCTEVMMVKSAIYYDTKIQSWEIPHTSEKFMVNSKILKLINKGNVYNEHETFIKTFSPLWKGDENIILILCMILLFSPDRPKVVHQDVIKLEQNAYYYLLRRYLESIYPGCEAKSVFLKLMQKLGDVRRVNEELISVYLNINPTDVEPLLIEIFDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXJ1</accession>
    <name>A0A6P7FXJ1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton-coupled amino acid transporter-like protein pathetic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114333741</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139532.1">
        <property type="nucleotide sequence ID" value="XM_028283731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXJ1"/>
    <dbReference type="FunCoup" id="A0A6P7FXJ1">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283731.2">
        <property type="protein sequence ID" value="XP_028139532.1"/>
        <property type="gene ID" value="LOC114333741"/>
    </dbReference>
    <dbReference type="GeneID" id="114333741"/>
    <dbReference type="KEGG" id="dvv:114333741"/>
    <dbReference type="InParanoid" id="A0A6P7FXJ1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF460">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="82"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028139532.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54008" checksum="BBA3A98243EBF7EB" modified="2020-12-02" version="1">MSKKNGNTSLLQQGAEKPIIAQLDQKKGGVNTVIMTNFKCDQNQVPTQSANGSTVPLVDTRKADPEVGDYDPFQHRANLPHPTSDLDTLIHLLKGCLGSGILAMPLAFHHAGLFFGLICMFIIGIICTYCVHILVKSAHEIYRRQRVSALGFAEVAEAAFLIGPKGFHPWAKFAKAMINFFLVVDLIGCCCVYVLFVAKNLKQVVDGYTEEEYHYDVRIYMAALLPFLICTNLIRNLKYLAPLSMVANVLVAVGLGITFYYIFNGLPPLSSRPHFASVSTLPAFFGTAIFALEGIGVVMPLENNMKTPGHFIGCPGVLNIGMFFVVILYASVGFFGYLRYGDDVKVGSISLNLPDEPLAQSVKVMIAVAIFCTYALQFYVPMEIIWKAVKNNFNRKTLAEYSIRASLVIVTVVMAILIPNLGAFISLVGAVCLSMLGLIFPSIIELVTFYEDPGLGRFNWRLWKNMFLIMFGLLGFVTGTYVSIQEIIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZ76</accession>
    <name>A0A6P7FZ76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114335795</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141884.1">
        <property type="nucleotide sequence ID" value="XM_028286083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZ76"/>
    <dbReference type="FunCoup" id="A0A6P7FZ76">
        <property type="interactions" value="806"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286083.2">
        <property type="protein sequence ID" value="XP_028141884.1"/>
        <property type="gene ID" value="LOC114335795"/>
    </dbReference>
    <dbReference type="GeneID" id="114335795"/>
    <dbReference type="KEGG" id="dvv:114335795"/>
    <dbReference type="CTD" id="65080"/>
    <dbReference type="InParanoid" id="A0A6P7FZ76"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19874">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="225"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028141884.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34665" checksum="D5A1006C2F03143C" modified="2020-12-02" version="1">MSFYKHSSLLKNQCLFLYVNYIRPTGCRNISRWVAPTLRELQRRRDKVGPEPERPRSSYLEWNYNAELFAFGKRLGEELDRSILKRALVQKEYANLAEFKAQNEGVAVEKLEHNDELIQEGEKIINNYLKKELSKTYPDDITKALIVYLTTEEMLSHIGVHIGLKDIILSEEFPVSKNTLSNTFKAVVAALKRSQDVARAENFVKDLVLTQLNGKDVYEIWDPKEPYEYLTKLLKERGITAIEPRLCNESASNTILACFQVGLYSNKKLLGLGWGENIKTAKETAALNAIQRLYSQNNANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZT8</accession>
    <name>A0A6P7FZT8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114332403</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138005.1">
        <property type="nucleotide sequence ID" value="XM_028282204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZT8"/>
    <dbReference type="FunCoup" id="A0A6P7FZT8">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282204.2">
        <property type="protein sequence ID" value="XP_028138005.1"/>
        <property type="gene ID" value="LOC114332403"/>
    </dbReference>
    <dbReference type="GeneID" id="114332403"/>
    <dbReference type="KEGG" id="dvv:114332403"/>
    <dbReference type="InParanoid" id="A0A6P7FZT8"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052637">
        <property type="entry name" value="KLHDC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46461:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028138005.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="44791" checksum="AFB3E1253C079BDC" modified="2020-12-02" version="1">MPWITCLEGGPKRVNHAAVAVGHKIYSFGGYCTGENSREYTSMDVHVLNTTTLRWTQHPVSDLPYFENDDILPYKRYGHTAIVYGEKVYIWGGRNDRASCSTLFCFDTVWHCWTAPKTTGHFPPARDGHTACLWKHYMIIYGGYEEHSDAFARIIYYLDLDTMHWTYVPIGGPEPTPRDFHTTVVINDRMYLFGGRGTLHDHFVGGRQVLYCNELWYLDLNTFTWHHCKVTGTVPVGRRSHSAFVYDEKMYIFGGYNSEKDRHYNNIYEFDPKTNIWKKLSITGKKPCRRRRQACVVVGDRIYMFGGTSPHPSVSSNSNSRNIDDKLRDHSDMHVLDFKPTLKTLCLMAVRNYKIEDSNLPQNLRTDIHNMYTPNKIFLNRPNNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3U8</accession>
    <name>A0A6P7G3U8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC114337394 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114337394</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143611.1">
        <property type="nucleotide sequence ID" value="XM_028287810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3U8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649555.1">
        <property type="protein sequence ID" value="XP_050505512.1"/>
        <property type="gene ID" value="LOC114338869"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G3U8"/>
    <dbReference type="OrthoDB" id="6744641at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027744464" evidence="8">
        <location>
            <begin position="23"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="10">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="190"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="636"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028143611.1"/>
        </source>
    </evidence>
    <sequence length="992" mass="111529" checksum="477E41D68C1B1B6E" modified="2020-12-02" version="1">MEVNGSFSLLCLWFSFIGLVSATLEINSIDTNSIIRKTRQSSLKCTLPPQIENGKWLITEADVQPGDQIEVNTIVRLECNEGYQLYPYNTLMACDSNWDEEDFPVCRKKCPSFYSTATTKLICKDKDENTITCDKATDGTYLTYSCVAFYEVPPGGKNVLYCNDGIWDFPKPLCKPICGKKVTTDTTELTWGGTDVKGYEYPWVIAMFKKLAGKYENVCGGTLVSRRVVVTAAHCVTDNYGNALGRENFQVAAGKLYNAFGDPRDKHAQYRKISQVVVHPGYRGVSQRYVADLALLITQELFKLEPVIMPACFDNVNTIYLKNYQVGEVAGWGLTEEEKPSERLRVIKIPYKEGATCSRELPESWEEQYNFLDKICAGRVDQQIAVCQGDSGSGLVFKNREDSRYYIQGLVSIAPNLYTSKCNYQTNALYTSVAFYYTWINKEMTINYLEDCLLPPHPRNGKWSVGGGEKKPGDIVLSNTILTFSCNRGYILSSISPHYDCANSYNPPTCLILCPKMSLPSGSQIICKNAKNQHIQCEDVADGGSVTFTCPNGFVSDRGTPTSTKYCRNGAFSNTAPSCILKALYKPTPEKHKKPSSSGSTEPYSLIPSKPITRPTKPSVSITVPEQGVEIGTDGLKVICTYASWMAYQEVYPENFESRLCTHLVYQFIGLRENGELRIGDEWLDLYFQEQGLYRMTTDLKQRNKDLKVLLSVGGSGATNETLFRDLSKDDDKIKAFLSSAAKIMETYNFDGLDIFWFSPAKDDKANFIHLLETIKRDFEKNGWILSITVHPVIEQHGYDAKEISRIVDWVTIKTYDFYGSWSLYTGNHNALYPSSKENGWEKQRYNLDAVAKTWLKAGLYKNKLVLGVAFSGVGFSLKDKSETGVHAPINKAPSFGEIRYYTICTKHADFTKVWDNETKTPYSYNDTFWIGFNDPQAVRLKGEYVKNEQLAGLNVFSIDGDDNKGVCGEKYVLLKNLNTGMGHSLTWLKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G437</accession>
    <name>A0A6P7G437_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable myosin light chain kinase DDB_G0279831</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114337502</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143759.1">
        <property type="nucleotide sequence ID" value="XM_028287958.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504338.1">
        <property type="nucleotide sequence ID" value="XM_050648381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G437"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648381.1">
        <property type="protein sequence ID" value="XP_050504338.1"/>
        <property type="gene ID" value="LOC114337502"/>
    </dbReference>
    <dbReference type="GeneID" id="114337502"/>
    <dbReference type="KEGG" id="dvv:114337502"/>
    <dbReference type="InParanoid" id="A0A6P7G437"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="466"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028143759.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="81179" checksum="CA61C9174A6243DB" modified="2020-12-02" version="1">MSWLKYPEKLFEWNEKIQYNTKEGIHLPTDKNSTRKKGNTTDTTNKNKNCSKSIIHGETSKQQSNATGNIQTTKVLANASKSDDKNNTGPHQNTILKKRTSDKTGNEDTNNSGEINSSVLTAKDPTNQLESKENTSSMGKPKNAKKQKKRKNKSKTMSTVVSCVKDPTNPLESRENSSSGGKPKDVNLPTDNSIILEKEQSNIKENAEKNNGETIINGTFGFVKGLTNALESNKNTSSESKCKEVNLCTGKTSKKEKKGKNSSQTMSISDSCLKDSTNPLQSKENISSVSKPEEINLPTENSMVLKEEKTDKINSQTINPLKIPKKPIENLNLSWVNNPKKLLETEEGASCSNITKKSKAKTENTSLPKNTSHNAAKNNLLHLDIVEQVIKNIKSNKEFKSVLEIVSNIMSNKNFGNRKTKCDLFEIFLEHYQYANPNYMKQAKETLTYCESHVPIASYFMDANDFEEEWGADLNYFGGKSKMLKGVISKNNVKREAVILYEEHNNCCMTRSHDKYIENEAAMLCQLKHPNIIELLGYDPKRKIIILEYMNHLDLARGLLNERVDLSIRNVQKILIDLLTGLEYLHSQKILHRDLNLKHFLFNDNNEYKIGALGKAVYVGNSSGVYQSSVPTLTRRLFDAPEWRGTKTYTYTYKTDVWTMGCYFKIILNKRSETFRLCRDEITDRLKLFVTNFMLAANPGSRKDSTELKSFLQNTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G523</accession>
    <name>A0A6P7G523_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114337750</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion outer membrane</location>
            <topology evidence="1 14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028144081.1">
        <property type="nucleotide sequence ID" value="XM_028288280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G523"/>
    <dbReference type="FunCoup" id="A0A6P7G523">
        <property type="interactions" value="1423"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652293.1">
        <property type="protein sequence ID" value="XP_050508250.1"/>
        <property type="gene ID" value="LOC126885642"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G523"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001271">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="429"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028144081.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="76859" checksum="152D2E57E4D3947C" modified="2020-12-02" version="1">MFSRPVPEKMVVKTSQKRTVRILLVGDSGVGKTSLILSLVSEEFPENVPSKAEEITIPADVTPEQVPTNIVDYSSAEQTEDDLDEQIRKASVVCIVYSVDDDDSIERITSYWMPLIRQNHPDGTCPVVLVGNKIDLVEYSTIDGIFEIMEEFSEIETCIECSAKTLKNISEMFYYAQKAVLHPTSPIYSVDKADLSEGCKNALIRIFKICDIDCDGLLNDIELNNFQSRCFNAPLQPQVLDDVKAVLRKNLEDGVCHNCVTLNGFLYLHNLFIQRGRNETTWTVLRKFGYNDNLNMSKEYLYPSLKVPTGSTTELSFKGQQFLTHLFERFDKDRDKALSPSEYEELFSTCPTPAWGPDVSSMVPTNEKGWITYQGYMCQWALMTLVDLPRTFEYLAYLGYNIYENETQVTAVQVTRDKKTDLAKKQSSRNVYQCHVIGPSASGKSTFCRSFIKSILESNPLQPEKTGVPNCTVNVIQVYGQEKIMVLRDINVRNVSDPLLPAEVQCDVACLVYDQNNPKSFEYIARIYIKYFAESKIPVLVVACKDDLEEVRQDYMLQPQSFCQKYKILPPQKFSAKGHNRKDVFIKLATMAAFPRFQAAWILFYKHSPLRRMVHALLVRPQPTEWLDHFCRNFREFGVMAADSTVWWKAGISLAAVTAIGFILAKVMHTADKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GB15</accession>
    <name>A0A6P7GB15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal-dependent decarboxylase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114339871</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146354.1">
        <property type="nucleotide sequence ID" value="XM_028290553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GB15"/>
    <dbReference type="FunCoup" id="A0A6P7GB15">
        <property type="interactions" value="1912"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646786.1">
        <property type="protein sequence ID" value="XP_050502743.1"/>
        <property type="gene ID" value="LOC126882016"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GB15"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055103">
        <property type="entry name" value="PDXDC1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055102">
        <property type="entry name" value="PDXDC1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF1">
        <property type="entry name" value="PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22930">
        <property type="entry name" value="PDXDC1-like_cen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22937">
        <property type="entry name" value="PDXDC1-like_cen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDXDC1/PDXD2 second" evidence="8">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PDXDC1-like third" evidence="9">
        <location>
            <begin position="517"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028146354.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="91370" checksum="4F2C8D93F6821E1C" modified="2020-12-02" version="1">MTTDNKNSLGELAIEASEIVSRLEQAAEGVPIPENVHNHSTVFLGLEKKHTDEIIKTIHGLISTDDEGEPLNFPSLDSVTKLVMVTHSLAVYCGGLERPILQKLSTRFTTDTTRWITQLFGFLDCSAFYHEDHLEGLVRVTRMMLHCKYPRYLEDGALTLNNSLPTVYSSVASPLGTVQHLCRQLGLPLACVRPVPVNTYFGSQYTMDVSALQKMLADDVATGRMPLIVIADAGTPVTGHIDNISRIRELCKVHGTWLHVRGHSVAALALPNYNQRNGTVPPIADSLTLTLGSWLGIPGLPMITLYRLWGTTNPNRNKQVGVSRESTLPVLAGLNTDHQSRRILSLPLWTGLQKLGTEGVHSRIKEDFLASERLWSALDVFRQVRMLSPKPGGESGTYTVAELVSKPSSIPLLMESTACSVVFQFVPETSDNSEYTAKVPPYYDKLNSWLGQILQIDAPQVPIDICELENIGVVLRFCPFENVCGQQPNLEEMQAFIVCLEQQLVILKATVHHRESFVKLVEVSPVLKIVDLPDWAGLGGVRYCPEGWEQILTDQAKEELNHLNMVLVDTLRSTDAAFSLGEGDNGLMCVRFGMLTPESDVEKLLDLVVKVGQSVEENSRVLDSMSEIVKKGIETATLDLQKENEERLWQEGIVRHIPIVGTFVNWWSPKTKDAGGIRGRSLNLTQGVVESTENIYKYHMQMGQGIAPGGITPPTPQIQTPIGGSHSRSSSHASASSQQSAVKLESSVKLDSSVKLDSSVKLDSSVKVDSSVKLDNPVKLDTSVNVKPDIVKSDGVVKLDSDFSKLNLENSLNKVNSQNKEVVEIKENNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GC92</accession>
    <name>A0A6P7GC92_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">D-aspartate oxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114340388</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146929.1">
        <property type="nucleotide sequence ID" value="XM_028291128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GC92"/>
    <dbReference type="FunCoup" id="A0A6P7GC92">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291128.2">
        <property type="protein sequence ID" value="XP_028146929.1"/>
        <property type="gene ID" value="LOC114340388"/>
    </dbReference>
    <dbReference type="GeneID" id="114340388"/>
    <dbReference type="KEGG" id="dvv:114340388"/>
    <dbReference type="CTD" id="36128"/>
    <dbReference type="InParanoid" id="A0A6P7GC92"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF17">
        <property type="entry name" value="RE49860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="311"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028146929.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37569" checksum="0B5AFECDFB41510A" modified="2020-12-02" version="1">MSDLKIAVVGSGIIGLTTGIELLKSVNNAEITIVAEGFNTDTCSWAAAGIFRPGHGFTGPNREITQKWIDDSYYYWKNIRDSVEAAEAGVTEISGYTFSNREKSIVRNAFIEKLVPIYRKATEKELTTLCPDSYKYGSFYKTLVTDSTVHLPWATNKFKSLGGKILKRHVNNLVSLGDQYDIVVNCAGLGAKKLCNDPHLTPIRGQVIKVNAPWVKMFFYAESDTYIIPGFNHVTLGGTRQYDSYNSEVDKYDGMSIRERCERLVPSLKPATEVRQVVGLRPHRTIVRVEKEILLTAGGKKVKVVHNYGHGGYGVTTAPGTSLYACDLVKEIWAGTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSD5</accession>
    <name>A0A6P7GSD5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyadenylate-binding protein</fullName>
            <shortName evidence="7">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114342350</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148982.1">
        <property type="nucleotide sequence ID" value="XM_028293181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSD5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293181.2">
        <property type="protein sequence ID" value="XP_028148982.1"/>
        <property type="gene ID" value="LOC114342350"/>
    </dbReference>
    <dbReference type="GeneID" id="114342350"/>
    <dbReference type="KEGG" id="dvv:114342350"/>
    <dbReference type="InParanoid" id="A0A6P7GSD5"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000091">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000234">
        <property type="entry name" value="Polyadenylate-binding protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="10">
        <location>
            <begin position="503"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028148982.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="66493" checksum="F2AA61D467BF5D59" modified="2020-12-02" version="1">MSAFQGVVYPSGSLYVGDLHPDVTEAVLYEKFNRVGQVLSLRVCRDARTRQSLGYGYVNYNQVMDAERAMDTMNFDLLKGKPIRIMWCHRDPSLRKSGIGNVFIKNLDRSIDNKAMFDTFSAFGNILSCKVAIDDNGHSKGYGFVHFENEQDARKAIEKVNGMLLNGKKVFAGKFIPRVERERELGERAKQFTNIYVKNFGIAMSDERFLKMFNKCGEITSWVVMRHIDGSSKGFGFVAYRDAKSAQAAIEEYNGKEIDGKVLYLARAQKKIERYNELKKRIEKIRLERYELYQGVNLYIKNLDDSFDDERLHKEFAPYGTITSAKVMRENGRSKGFGFVCFTSTEEATKAVAEMNGKMIGNKPLYVGLAQRKEERRAYLNSQHLQRAQALRIQNGLTFPTTTPPFLFPTVAQGPRFFNHINSINHIRPTARWPVSNAIRPNGTYNLALINSPHRVSSRTSVNTRNSINARPITGQQTAPSRPNSKYTNSSNNSARPAPAGVGNGGDIPNNGLPNVQDQKQLIGEQLFTMVHKMCPEISGKITGMLLEIDNSELLHLLENKDSLKARVDEAIAVLQAHNANLKKVIIVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GYZ5</accession>
    <name>A0A6P7GYZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC114344006</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114344006</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028150658.1">
        <property type="nucleotide sequence ID" value="XM_028294857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GYZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653947.1">
        <property type="protein sequence ID" value="XP_050509904.1"/>
        <property type="gene ID" value="LOC126886849"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GYZ5"/>
    <dbReference type="OrthoDB" id="10264920at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF2">
        <property type="entry name" value="ENKURIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="7">
        <location>
            <begin position="174"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028150658.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30554" checksum="8A9DA71A765DCC67" modified="2020-12-02" version="1">MSRFLMKQIVYKTNMPLKTLGGIFDEPKKAPKKNFIRENIKALKHLESIVQEAQKVEQTKSLSRGSSPKRFPRDKTKSLSLGDLRVPKENTIPNNKDQSVNAKSIHKTLSAIDRIKNLSKSKGFKPKKTVSEKKCKPQLSDRSVQTDFDDTFLIEINSPTIIPDVLPNTKEGHSQTITPEVPLIVKGVVTLEPQYPPGHTVLPESERIETLATYKKNYDKLINELNSLPLTCDTLRIRKKRIKIEDELLKIEEAIKMFERPRVFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZG4</accession>
    <name>A0A6P7GZG4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114342556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114342556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149175.1">
        <property type="nucleotide sequence ID" value="XM_028293374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZG4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293374.2">
        <property type="protein sequence ID" value="XP_028149175.1"/>
        <property type="gene ID" value="LOC114342556"/>
    </dbReference>
    <dbReference type="GeneID" id="114342556"/>
    <dbReference type="KEGG" id="dvv:114342556"/>
    <dbReference type="InParanoid" id="A0A6P7GZG4"/>
    <dbReference type="OrthoDB" id="6783553at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028149175.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="26284" checksum="CA9903F2AD0CB7C6" modified="2020-12-02" version="1">MQKVNSFYITKRNIFKIFTMEVVSVDEIKDIISSISNETQKHNINPFTEEALFKFDLYKNINTRTLHSQSTSLEYLKNLNDGITADVDRIKDTSRNNKSYVAKSQTNADDLNNRMNELQMKCTDVKKEINALEHKISHMEAKEKHFQKKRDEILVFKLLTNTHFSYDTKKVRGYVTGKTSDSSKTFDFNPQQMDNKKITDNLYNALKACCNTRSPGGKEDKENEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6Y4</accession>
    <name>A0A6P7H6Y4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sialin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114347815</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028154312.1">
        <property type="nucleotide sequence ID" value="XM_028298511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6Y4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028298511.2">
        <property type="protein sequence ID" value="XP_028154312.1"/>
        <property type="gene ID" value="LOC114347815"/>
    </dbReference>
    <dbReference type="GeneID" id="114347815"/>
    <dbReference type="KEGG" id="dvv:114347815"/>
    <dbReference type="InParanoid" id="A0A6P7H6Y4"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028154312.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53020" checksum="63AB6019C587BC86" modified="2020-12-02" version="1">MVNVQLPLKSKIPIRFWIACMVFLTTFTCYTTRVNLSVSIVSMTKGKTKGIPYCKLKEGTGNGGNESHELPDYGTRYDWNERIQGSLLGAYFYGYILTNLLAGLTAEYFGPLKVILLVHAVAAVMNTVSVFAAGWHWGVLFFCRLVLGMGGALVYPSLQILIAFWAPPQEKGKFVSALMGNVLGTCVTWPVVGLVTTYLGWHWGFYVVSLVNVLFCIVFFLVVTDTPETHRWISPEEVAYIKESQQGTVVKKKVVAPYKDIFKNFPYWMLMICHFGNEWGLYLQLTLIPKFISDVIGFDLSQAGGLSALPPLMRMTFGLVLGYIADELLRREIFSKRVVRKSYTVVSHVIPGILLLIISFIGCSWIPIIILLTLSLGFNGACVQNTLINPQDLAPNFSGTIYAINSFFAGMTGFIVPTLNGEFTKNESGITQWSYTFIIGGAVYCASGVIWIVFGSVEEQAFNRKGQPTATTTTENTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H814</accession>
    <name>A0A6P7H814_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metaxin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114348330</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154717.1">
        <property type="nucleotide sequence ID" value="XM_028298916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H814"/>
    <dbReference type="FunCoup" id="A0A6P7H814">
        <property type="interactions" value="1448"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642286.1">
        <property type="protein sequence ID" value="XP_050498243.1"/>
        <property type="gene ID" value="LOC126879235"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H814"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="10">
        <location>
            <begin position="173"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028154717.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33823" checksum="0D7D0D980E75BF2A" modified="2020-12-02" version="1">MDQKHKFQLIVFDGDFSLPSIDPESIKSILYTAVAGVPVEVRLFNNFKNCTLYTAPTFIHKNLKFKTFSDLVLYLKTLHFNLDENLTPKEASESLALTNLVQSKLRPLLEYYYWADVRNTFELTNIWFMRSLPIPFNYIYTRRFRDRAVDLLESLHPTETNFDLIKEYVQRAATECLSNLSTRLGNENYFYGNSPTTIDVLVYSYIAPLLKVPFPSNEIKNVLSMWPNLANLVKRIDDQYFPNLPKGSKYIKIEEKVKTSDDEVSYMAILILTVSATSLVFGFAYSRGYLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAR9</accession>
    <name>A0ABM5IAR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128750.2">
        <property type="nucleotide sequence ID" value="XM_028272949.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272949.2">
        <property type="protein sequence ID" value="XP_028128750.2"/>
        <property type="gene ID" value="LOC114325025"/>
    </dbReference>
    <dbReference type="GeneID" id="114325025"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128750.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="390" mass="46086" checksum="28480904E6B1E256" modified="2025-10-08" version="1">MIFLKYILCLQITPIYIIFRQFLYRFFYFFLLLNKVFCRKLAKDEKRNIKLEKPIRKRKKKVSKENDADYVIKEEDEDDDEKDIKDIKVKKERKKREKKPKKPSLREIQRLLQKDSNPFIVNLDELPTPLVCPVCKESFQTNREYAYHSSEHNDDGQYVCHFCDYKTDVKKQIKAHMIQHSVFKCMVCEKIFKKRHSAYKHGERHMDNNKVQCEICGKSLQSQSLKTHMKIVHTDEMLDQRHYCPICNKAYRYSSSVRKHISANHRELGIDVSVVCDICGKRISSKSKLTKHLSIHTGDKPHPCAVCHKRFRAIDTLRSHMVVHTGEKPYKCMYCGKAFGQNAPYRYHIKTHTGERNYSCSICGKGFISKANWRLHVKTCDIMATGKMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABM5IIW6_DIAVI</name>
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        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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        <lineage>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028278043.2"/>
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        <property type="gene ID" value="LOC114329034"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046340023" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133844.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="102" mass="11451" checksum="DFDFCBC88FB994BF" modified="2025-10-08" version="1">MNTILVLALLVCVGLTVSAPQNNDFLCDGCVSLSTVLKKYVQEELPLKDLEEELTAFCQALSGQLRDFCEKELIPLVDQIYDELSDTTPREDCEFLGFCEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJJ4</accession>
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        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomelidae</taxon>
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            <taxon>Diabroticina</taxon>
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            <taxon>Diabrotica</taxon>
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    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134276.2">
        <property type="nucleotide sequence ID" value="XM_028278475.2"/>
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        <property type="protein sequence ID" value="XP_028134276.2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="34"/>
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            <begin position="70"/>
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        </location>
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            <end position="191"/>
        </location>
    </feature>
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            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134276.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="35956" checksum="E456E02564F34CC1" modified="2025-10-08" version="1">MRKVLRVISNLFVVFMLCTLSTQIMSMYRVFLYLRHGKSFVKILNSVIKIWKNLQGDNNLFRGIFVNRKIYCIQLLLIFFVVSLLATEDFIRGHQLTDMLSYSLTEILVLISILEKVNVILMFKKVFGVLRQRIKGSKMDSVEDIYDKYYALHKLLEKYSKLNSGFFFYVIVNCFIWSMYNIYKFIILIFFEFTKFPTRNFSMSILLSFTWIFLHFFHLAILIWAYNKVNVEKKNFIYDLSLKFCSLGVETRRRYSDLIVSISTDLLMYTHEKNAVIFDLGPPLMLRIFGSCVTYILVLVSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKB2</accession>
    <name>A0ABM5IKB2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport and Golgi organization protein 6 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134773.2">
        <property type="nucleotide sequence ID" value="XM_028278972.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278972.2">
        <property type="protein sequence ID" value="XP_028134773.2"/>
        <property type="gene ID" value="LOC114329738"/>
    </dbReference>
    <dbReference type="GeneID" id="114329738"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="4">
        <location>
            <begin position="251"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="663"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134773.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="105676" checksum="F00A2285FB2EC078" modified="2025-10-08" version="1">MNKNQLLECVKLLALAEIKDGSYTSFLESSLNEVYNKLGITHEDVLSEIYDIASLNFSNNVDLEWKYICLAFFIIKALGKESEKADDVFLSVQETKDLKGFINDVVIIGIQTKLIPTLPFYMQSRYFVSEDIFWSYNILKCTTFGLTEFMKLPVLRLCILPENLKIILAALYQIAYGPVKKPTYESTAPMTKEIYEKLIQEQKLFLQILNHLGQTVHPSIFIRETMVMFNAKIPSWFKKHLFQNLTSILRSQKGVQTVASALFENCESNTQNWKILDVFSKLILHCMKFPDFKENICKQLVDLLHNQSSEQSIAENIFTHCTKIIYTKDVGLCSDIFVKNIMTHFMCFTQKTQQCCKEDITETIKLTSRLLHAVFVESNAQENVLPSSLLTKIISVIFRFFVITIDSSFKTVNNDLADILLLFFESNQEKSLDVLDQILFNLKSSEILAFRDDVELDVQANRITLRHVQHSVQYSPSENCEALLKLCKRKPKLLVSFFGYLLNCISSESKYFPKNNEGLVRIEEDITTSYIERKIVVYKLVSELADEKDVQKQLNEKPAVIVDYIYNVLNRTLKLSTHTKEDCDSEGFQAVFTILMILENLLETSDRNTHTHYDILINPLKQIKEESGNKETKDIIQNILNILQGHDVSKQKIVEDKDKTELDQILEDVCDPLLPTRGHGLICLSKLIEKKDPDVMERKHYILNILLQNLTNKDSFIYLSSINGLAAMADVFPDTVLKVLCDEYSDSNRKDVEDSSESRMKLGEVLVKVSKMLGEMAPKYKSTLLNTFLMGTRDEDDLIRASSLSNLGEICQVLGYKLGSMFTEVLSCVHAVISTDKSPQARRAAVSVIRQLFIGLDQEIISFFKEDILPVYRTLKQIYSSDKDDVMRLQAQLALEELNESMKNFVFPNAQLHSEKKIVMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IN49</accession>
    <name>A0ABM5IN49_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136967.2">
        <property type="nucleotide sequence ID" value="XM_028281166.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281166.2">
        <property type="protein sequence ID" value="XP_028136967.2"/>
        <property type="gene ID" value="LOC114331560"/>
    </dbReference>
    <dbReference type="GeneID" id="114331560"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF71">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046888517" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136967.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="680" mass="77727" checksum="B60C05E9A55AA747" modified="2025-10-08" version="1">MRILCQIFLILVFWLGLSVPSDISIFPALPVTVTNTSNLLCNKHSREYLENLKNFTLWAYEMRDASAQSISSVLTGSSYSLGNQAECLTAHAPFPTQYCLAIIIGNIPNTTIKRDPLSLEFNSNENVLDKLYPYQDETKFPRNIAKMGWCFPASCSPNDAKESLDNYLQHVDYSLKKDNITFSAQVPSILCQCSDKQLKMDTVDFVFCGLVIVLVILVSSSSYLDNPDEDDSKNKQYKLLQAFSMKRNIKDLSKIEATEKPLRIFYGMKAFSLIMILTGHRSALFTAAPQITLDYVEELYRTLWAAIIFHADLFVDTFFLISGLLVTYGLLNNLNTGKKFNPVFMVVARYLRLTPLYAFCIFYQATLLYHMGNGPLWEPVLGQEREDCRKNWWTGILYVSNLIDSEHMCMVQSWYLACDFHFFLLALVLIYILHKSTRCGILVTILCMLATIYTTFSIIYVYQRPAFLRFLPKFLENPKGSYDYNLSYIKSYTRGLPYFIGIIAGYIYIKYKTKDYEISQGRYYGILVIASSLIAILIFSGKVLYNPYHKYNVLEASIYGSVHRLLWAVGNLAFLYGISFGPEGLLYKFFSWTIFVPLSKLTYGAFLVQISFQIRDIGLSVNPKKFDVFNVLGLIILDAVYSFSLAFVLYLLVEQPFKKIARIILNLDKPKNSEGANKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INY9</accession>
    <name>A0ABM5INY9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137723.2">
        <property type="nucleotide sequence ID" value="XM_028281922.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281922.2">
        <property type="protein sequence ID" value="XP_028137723.2"/>
        <property type="gene ID" value="LOC114332185"/>
    </dbReference>
    <dbReference type="GeneID" id="114332185"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137723.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31519" checksum="4873F85FF13E0CB3" modified="2025-10-08" version="1">MDINTEALVETLKSLKCTYCGNILSIGPIMIHSISQHEYEYQCGRCEDITRKGPPVRALLYESVAKHLWFPCIYPKCNETYPWDFVKIHEKNCPHKTNCCQISQCFEKLDENDIIAHMTEKHPAAICVNNNIIFNFTINEDSSFYAVINSFIFLIYFRNSKIFISLLSNNSNNVFNFTAKLRNIEEKTPYTYVRGRVINKFDENRHCSNCRDHRLSIEKKLGPRRSLRIAKVKEEVVANETVKQVAVAEVKIYHYQFITNHFCRLYPVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IP32</accession>
    <name>A0ABM5IP32_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="30 31">Poly [ADP-ribose] polymerase</fullName>
            <ecNumber evidence="30">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:54424"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:58224"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15089"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142540"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:58225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-histidyl-[protein] + NAD(+) = N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72071"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:18085"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:191398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:72072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-seryl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-seryl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58232"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15091"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142556"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:58233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-tyrosyl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-tyrosyl-[protein] + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:15092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142557"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:58237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26 30">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="30"/>
    <dbReference type="RefSeq" id="XP_028137801.2">
        <property type="nucleotide sequence ID" value="XM_028282000.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282000.2">
        <property type="protein sequence ID" value="XP_028137801.2"/>
        <property type="gene ID" value="LOC114332242"/>
    </dbReference>
    <dbReference type="GeneID" id="114332242"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17747">
        <property type="entry name" value="BRCT_PARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08001">
        <property type="entry name" value="WGR_PARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038650">
        <property type="entry name" value="PADR1_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008288">
        <property type="entry name" value="PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049296">
        <property type="entry name" value="PARP1-like_PADR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012982">
        <property type="entry name" value="PARP1-like_PADR1_Zn_ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF112">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21728">
        <property type="entry name" value="PADR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08063">
        <property type="entry name" value="Zn_ribbon_PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000489">
        <property type="entry name" value="NAD_ADPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01335">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52007">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20 30" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 30 31" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 30" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 30 31" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22 30" id="KW-0539">Nucleus</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="21" id="KW-0804">Transcription</keyword>
    <keyword evidence="18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10 30 31" id="KW-0808">Transferase</keyword>
    <keyword evidence="16 30" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="32">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="32">
        <location>
            <begin position="119"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="33">
        <location>
            <begin position="380"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="36">
        <location>
            <begin position="528"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="35">
        <location>
            <begin position="646"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="34">
        <location>
            <begin position="769"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00024159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRNR" id="PIRNR000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137801.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="991" mass="112411" checksum="F850976F3E87CDE9" modified="2025-10-08" version="1">MSKTDLPYLAEYAKSGRASCKGCRTPIGQGTLRLAVMVQSAHFDGKQPNWYHFECFFKKQRPKTVDDIEHYESLRVEDQDKIKGRVGLSSVTIVPDKKGKKRAGDKIDAKLKKEALKDFRIEYSKSGRAACRGCEQKILKDEVRIAKKDFETEVGRKYGGQDLWHHVTCFAQIRADLGYFESGDKLPGFKGLKKEDQNTVIKAIVPIKQEDIPEVKKAKVEDEVDAPPKEDEEYRKQNKLLFKYRDALSQYEGSEFNKLTTALLEHNGQAHCKGREKTLDHLADIMTFGALVPCDTCKGQFVYSSAGYVCKGDLTDWTKCNKTVMEPKRKPFKIPDDLQHYSFLKSYKYKPRNRIIKVKVPTNGVKKEKEEENAEPRVKRELPPLYEMKFVILGLSGKSKEAIKKEVTALGGKVVTKIDKTVMAVITTKEEVEKLGSRMQEAESEGIHAVPEDFLKEAKGKTGKIPDLIVKKSICSWGTDPTVRLPQPASTSSKSKSQSIYTKSVPKSVKLKLKGGTAVDPDSGLENTTHVYQSGNDKYTAILGLTDIQSGKNSYYKLQLLEADGRNSYWVFRSWGRIGTTIGNTKLQKMDSLIHAKQNFEEVYEEKSGNAWRNRHNFKKVPGRMYPIEMDYGEEEAEKLDIVECDSKLHPGVQDLIKVMFDVNTMQKLMLEFELDTEKMPLGKLSKSQIQKAFGVLSELQTLINEKAERSRFIDASNRFYTFIPHSFGVDDPPILDDPEVIKQKIEMLDSLLELEIAYNLMKTSGSEHTVDSYYKQLNTEIDILEKTSEEFQIIEEYVKNTHAATHNTYELVIDQVYTVKRKGEEKRHKPFRKLPNRKLLWHGSRVTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCCTNVNSPLGLMLLCDVALGNMHERLQADYIEKLPKGTHSCKGVGMTHPDPSVVKKIGDIEVPVGKGVSSNAKSSLLYNEYIVYDVAQVNIKYLLKMHFEYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPP4</accession>
    <name>A0ABM5IPP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138289.2">
        <property type="nucleotide sequence ID" value="XM_028282488.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282488.2">
        <property type="protein sequence ID" value="XP_028138289.2"/>
        <property type="gene ID" value="LOC114332660"/>
    </dbReference>
    <dbReference type="GeneID" id="114332660"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008092">
        <property type="entry name" value="Ribosomal_mS29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01716">
        <property type="entry name" value="DEATHASSOCP3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138289.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="387" mass="44322" checksum="7F084AC6B0AC48BE" modified="2025-10-08" version="1">MLNVLIRVFPKNALPRKVPVCNLSSAPILLNVEKLQRFRTSESDCLKHTSDHLAQFYQISEKEKKQIFLHGGIPKSFNVQTKTFNETCFMIRQPSLDIINCLKSIDHSKPTVRFVLYGKKGSGKTLCLAHVLHYAHKAGYLIVHVPWLGNWMRRCQECSNSETKEGFVDLNIDAAAWLLHFKTQNAHILSSPEAQTTKEYAWSKREITPKDSSLLELIEHGINRVKYASDTVVALCDEIKTLSVRGVLKTFVAVDGFNAFFYPNTRVYTEKKEMVHPQKVTLTEGFMNLTKFDWNNGAVVVTVDEIAIAEKDQISHMPRYLLGKDGFEHLDPFIPVHVADYSKKELTSCMDYYRERKWVKDYPGLDEEVQFVSGSNPYRLMKVCAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPR3</accession>
    <name>A0ABM5IPR3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138319.2">
        <property type="nucleotide sequence ID" value="XM_028282518.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282518.2">
        <property type="protein sequence ID" value="XP_028138319.2"/>
        <property type="gene ID" value="LOC114332688"/>
    </dbReference>
    <dbReference type="GeneID" id="114332688"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045513944" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="43"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138319.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="297" mass="32788" checksum="ED84DBBDE74CFF5D" modified="2025-10-08" version="1">MNAIVIVITLVYIACCQIEVTESFNHTIFAYPENAIKKSTLRIIGGDNVTPNSYPFQAALFIYYKSKTNLCGGSLIDKEWILTAAHCVDNDPVRIVVKLGLHDVYATQESTVQIYEAKSYYKHSKWNEKTLQNDIALIKLPRNATLNNYVNLIKIGDNIDYAGRVATVLGWGSTEDGQISKYLKKVDVDVMTNQACKAVRKEFNEIIVSTHLCTSGQGIRGSCSGDSGGPLIVDGVQIGLVSFGPENCMRGFPSVFTRVPKFASWITSTKRNSGTSLNVNSFVICIVSLMFFINISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQZ7</accession>
    <name>A0ABM5IQZ7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139207.2">
        <property type="nucleotide sequence ID" value="XM_028283406.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283406.2">
        <property type="protein sequence ID" value="XP_028139207.2"/>
        <property type="gene ID" value="LOC114333521"/>
    </dbReference>
    <dbReference type="GeneID" id="114333521"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045828571" evidence="2">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139207.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="263" mass="28329" checksum="523E4F6163AE0585" modified="2025-10-08" version="1">MKLLLLALCTFLVGQAYSKGQAYTVTQIYPTQSLELEFNGSKVCVNTNKGAKNTTDGSNQSGEKPHSGEKPHSGEKPHSGEKPHSGENGAPNSGEENGNRGVSYTLNRTDKDNVKITVISLVSRSDKKTRDLPATNQTLCKIAIPNRKDKIIIVRFGNKISKAEADAGRGDNHSKEDKSNPKVYYRIEAVQQNGGKPLVVVGKGIASISYTKVSLKITYTISVSIQEISVVVAINGSCSSGEKGQETNLHLEEKPTSPCARDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRZ8</accession>
    <name>A0ABM5IRZ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140195.2">
        <property type="nucleotide sequence ID" value="XM_028284394.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284394.2">
        <property type="protein sequence ID" value="XP_028140195.2"/>
        <property type="gene ID" value="LOC114334358"/>
    </dbReference>
    <dbReference type="GeneID" id="114334358"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140195.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="328" mass="36611" checksum="074481268D639A9D" modified="2025-10-08" version="1">MVWTAKYNRHHLQEIYSEFDNEFLLYLANSAFGYYTDQKPEERNTSIIDEAEIGPLLDCSGLMTFTLFTRDSPGGWLVDDPDKLPNYLKKTEIKFVTHGWLSRGTAETCVEIKNAFLEKYDINVFVVDWSSITDNILYSVPAQGAPCIGEEYAKFINDLIEKFNVNPKDIHLIGHSLGAHVSGFAGRKVNKKISRITGLDPAAVGFQIMHINKNDADFVDIIHTAAGLVAVLEPIGHADFYPNGGTIPQPGCGILSVLNSCSHSRSWQLFAFSIKLDQQFIAHKCETLDDAFLSNCKGELFPMGYPTPPTARGIFYVKTSSVEPYIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISA6</accession>
    <name>A0ABM5ISA6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140443.2">
        <property type="nucleotide sequence ID" value="XM_028284642.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284642.2">
        <property type="protein sequence ID" value="XP_028140443.2"/>
        <property type="gene ID" value="LOC114334576"/>
    </dbReference>
    <dbReference type="GeneID" id="114334576"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140443.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1043" mass="118664" checksum="472678469AF99D7C" modified="2025-10-08" version="1">MDTTIRISSKTVKNKSDFLHVTYNTGKSKDAVISLDSSNFGQSGSVTWDKKSSTLSNIEKVTNWMKQSDKECVDMDSLEESSSNDSESKSLILFRCDFNKPTKPPSHFPSLFNRSTSLIDYFKNESATRSKPSKGSTVSSMKDDVALMEKKPVKNFPIDSPDRVSNNILTSDNSYTSENKSEITDEIPLSPESQKKELCHYLQLMNPADKKEIIILQNRRSSRVRNLEEQKQQFQERFKEVNDGDKEKIETVQKSTSPKSVNEVQLNNMSNSKEFSLPFPPKKILTNVIDFDNVMSDLIPKFKKYCESNNLSCMQKLREQTKESNVLKQKKDCNTVISRKTHSKKVVHKKIKKSKIKSLVKTRSRASLKSLRSNGNLKHVPIRNLVEKSQRGSSVKNKRAKSVAASSNRSTLNCTPISIRSSIPQITSPKSIGSHCEIISVDPGLDEDQITIDQILEEIPDFELLSDEYKRCLIESRILNTNILTTNKSHVTESYHFTEAPLYGFTKKDTQEVSNMCEKYKKTVSLTDEVKESVEKPKEIQDVGRKRDKEERQETNNSNNGNTYFIVNIDTSGNTAEISDSSQDSEPSNSSTQKYDYSAAISNKGENSDNEELFKAVPIANVEKGNYLEINTKNITKNHNYEVTPYKKPDCIKSLHKSLQFSSKKKNSLTANSSVCQEWDINNTKQKLKKQSHTISIDSENGSVLKAFYVGYNLILCQEFLVSFWMQTPLGNVLGSQQMWIPRGQTQRISLNNRCLQKDSMEKVICLDTSVVYIELWMKEHKSEVRQGPVADVFITLYYWKQRQNGLDKRVLQLENINGFADDVQYCVMRNFPKIIVSWHSANEDNLNSRKTFVHAYQLASDYQTISNIFDMEPVSHYVSSLHSVEDYDDLIMGCGENKISLWNLQFGNIIATIELNDIKTPLSTLWVKCDRGFLFALQQCVDRELRLVAINGINHSWKKLASYFPPEGFDRLKGVCIDNGLLLSFYDQGILCWNTETGEPVEEINGETDVIPSGAYVILVENTKVVVKHAFTHLMSLSLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IW63</accession>
    <name>A0ABM5IW63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028144850.2">
        <property type="nucleotide sequence ID" value="XM_028289049.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289049.2">
        <property type="protein sequence ID" value="XP_028144850.2"/>
        <property type="gene ID" value="LOC114338446"/>
    </dbReference>
    <dbReference type="GeneID" id="114338446"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144850.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="340" mass="39546" checksum="3A60DEBC0DD17208" modified="2025-10-08" version="1">MNSKIYIGLIVSIIVLILVYLNVEHKVQGWDKNVDRNVSHYLSHISTQIVPTRFCNEPLKTLIIVTSAPSNENERQTIRETWGNTEDIKKYNSTVMFFTGKSSDPEIQKAILTECEKYDDIIQEDFVESYFNLTLKSTLIMRLVSNRCIGRAQYLLKIDDDMFLNVPNLFEMIVEKNKSENLLIGLMECNARPIKDPFSKWYTPNYLFNETVFPNFVAGISYLMSVDTSLKLYKAALTTPLFHLEDVYLTGLCARNAGIHPEHSNQFIRSAPDDEPCQFKNYIAIHDMTPSRMRNTFYSLSDSSLMGECSNYEEMFNVRQWMWNTLFTPYSRSKRKRLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IX22</accession>
    <name>A0ABM5IX22_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146303.2">
        <property type="nucleotide sequence ID" value="XM_028290502.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290502.2">
        <property type="protein sequence ID" value="XP_028146303.2"/>
        <property type="gene ID" value="LOC114339818"/>
    </dbReference>
    <dbReference type="GeneID" id="114339818"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF434">
        <property type="entry name" value="FI01124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146303.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="456" mass="53701" checksum="AEED4BBE793EC02D" modified="2025-10-08" version="1">MSKYQLYSKLKHINKFINNKMDVKQEFSKESCKLDDALDALVDGFKCEVKDEFNRSAYDTYDYLDLKECPIKTEIEQDENKLNAFEENQKTEKGFTQQENKMKIMETFCEHPSDKEHCTSQHAEETTVNKNIKVQARQGCYKCEICFKHFSRAHHLKEHLKMHTDKKPRKCEICSKQFTNLSDLKRHMRVHTGEKPYKCEICFKQFGLASTLKVHLRAHTGEKSYKCEICFKRFSQNGHLKRHLSVHTGEKPHKCKICFKQFIQAFSLKTHLRTHTGEKPHKCEICLKQFNCSSHLKTHLLVHTGEKPYKCEICFKQFSRNEQLKVHLTVHTGKNLYECEICSKPFTKSNDLRKHWRVHTGEKPYKCEICFKKFTEAGSLKIHLRVHTGEKPYKCEICFKQFNRGSILKQHLKVHTGEKPYKCEICFNLFSLASSLKRHLSVHTEKDPTSVKYCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IX97</accession>
    <name>A0ABM5IX97_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146733.2">
        <property type="nucleotide sequence ID" value="XM_028290932.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290932.2">
        <property type="protein sequence ID" value="XP_028146733.2"/>
        <property type="gene ID" value="LOC114340214"/>
    </dbReference>
    <dbReference type="GeneID" id="114340214"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="169"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146733.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="389" mass="45114" checksum="AF4148C623A7B4E5" modified="2025-10-08" version="1">MYTSSGEEEALVMLAMEDDNSRKRRKWVHDINLERLKCGEYHTLMPQLRKDDKRCYIYFRMTIDCFDELLHLVENDIRKSDTNYREAISPEERLAITLRYLATGDTFYTIGHSFRVGFSTVSAIVVEVCEALCRNLQHIYLPEPTTEIWKKSEEGFRNTWRFPNCIGSIDGKHVTIKCPDKTGSNYWCYLNKFSTVLMAIVGPDYRFISVDIGGFGKNSDGGIFEASNMGRRFETNQMGVPEPKNLPGQNELSPHVLIGDEAFALKPYLFRPFPYSQSRTDIFKENYNVRLCKARRVVENAFGILAQKWRIFYRPMETKIDTSILIVKTACILHNFLRTKKCDDRFIELLDPPEPELGAFQNLDNDPRRAARLAFSVREKFATYFNSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0J3</accession>
    <name>A0ABM5J0J3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155656.2">
        <property type="nucleotide sequence ID" value="XM_028299855.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028155657.2">
        <property type="nucleotide sequence ID" value="XM_028299856.2"/>
    </dbReference>
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        <property type="gene ID" value="LOC114349472"/>
    </dbReference>
    <dbReference type="GeneID" id="114349472"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
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    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="match status" value="7"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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            <end position="216"/>
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            <begin position="1532"/>
            <end position="1559"/>
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        <location>
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        <location>
            <begin position="1602"/>
            <end position="1631"/>
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            <begin position="1"/>
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        <location>
            <begin position="244"/>
            <end position="280"/>
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        <location>
            <begin position="819"/>
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            <begin position="22"/>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0P5</accession>
    <name>A0ABM5J0P5_DIAVI</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Cucujiformia</taxon>
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            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </evidence>
    <sequence length="211" mass="24748" checksum="8A3C91B6CD289355" modified="2025-10-08" version="1">MSKILNRYLKSFLNLETKLINMRNVSYIQGQSPEPKVREYFYYIDHQGMLFLDDARMKNFTSCFKEKKFLRFFFNQLRINTTARYQEFPYISLCGKERNFVRCDDYPIVYTHIVHKTDPDEIHLGYNHAGDLLTTKFLPDKVIMLPETGRVYHPCSDKTGGVGLVASKLAIEFSKAFTFENGDLNPPTHFTFENITYELDSSWYQKANKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABM5JJ83_DIAVI</name>
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        <recommendedName>
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        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="LOC126879099"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
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        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="113"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="625" mass="70290" checksum="61941860FD6B60CD" modified="2025-10-08" version="1">MTTKNANSEPAMGPPKKKLKKNGTTDKSKKIKKSVEGSTKHSKTDKPAPKKDFTKPNSKFVSNNNFRDKKTGKFDKDKNKPEIFENWNEFKKKKKELKLKRRQNKDGFDVIVKAKRIGEELRKKSLNGGEQKRIQLINELHSLLKGGGHYPKFVLAHDTARIVQWLLKYASDLVINQISKELIPVSVNMLQSKYGIHCVKRLLKYGKNEIRSQVIDAMVGHAVKLSTRNISAPVVEYAFSTWATPLQKQYLVQEFYGDLYRSTKDNNVKHLRDTYKDNPGLKDANLGATKANLIKILNKSLLDSGLVQTVLYQYLSECSAEDRSEMISQLVPHIVVISNSKDGAKAAMQCIWYGSTKDRKGIMKAVKEHVVELSKHEHGHATIITLIDCIDDTVLLHKIIVSDLLKNAKDLAINEWGMKVLLWLVTPADSTNFHPQFIKEITGGREASTSKKSAEIRRKEILGYSIPTLLELVAKDAEFCLSSPSLAIKMIAIVKAGSGPELEAAYTGLADVIVNPEWKVKENENDILGVENAGIHMALKKLAQQDKVRLENQDITFGSVLIEKLTEDTLTSWLPLNRGCFLLVTVFENGSEETQNKMKEKLQKSLKLLKKQTSPGAKILLKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKG5</accession>
    <name>A0ABM5JKG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PHD finger protein 20-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498430.1">
        <property type="nucleotide sequence ID" value="XM_050642473.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642473.1">
        <property type="protein sequence ID" value="XP_050498430.1"/>
        <property type="gene ID" value="LOC126879459"/>
    </dbReference>
    <dbReference type="GeneID" id="126879459"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20386">
        <property type="entry name" value="Tudor_PHF20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF51">
        <property type="entry name" value="MBD-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="MBD" evidence="14">
        <location>
            <begin position="503"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1222" mass="138713" checksum="543AB5DCEFC59198" modified="2025-10-08" version="1">MGRKCNVKGCPSASNRSKDEGVTFHKIPPHMDVRPKWLSLCRIPEDKKNIKILYVCSRHFLRADFCNFKGKKYMLKHGVLPSVFPWDKSKLEAIKAVVKNEKVVKKDKTEAKEKPSTSIRPEQDILQDNRMEEDNSDINQENDMGEDKMMDESMTGISRPEKQLPSSIPATLNFAINSYVEALDFNNEWCLAKIMETDEEEKEVLIHFIDIPSKHDEWISMNSSRLRPAQNVDLNHSANPVVSLESDIDQTSIVNTIPIEASISTEAESSVLPTSSVISTIENVSILPSAPIASATVSTVSPTVSTVSPTVSTVSPTVTTVSPTVSTVSPTTSTVASETNVKKEVEVETYVVGERCLAAWSDCRKFPATVSKVLENDTYEVIFDDGFPKVLKAHRMAKALGRHLQSSPLFEPIRTTKQDRRTKKRKLNVATLFKKRRRIAKSEDKQKRSSAASLPLSEEAQEVLIDYPMRELTAEEIENWKPSWYKGKPVGIESTLKTQDGLKTSYIVPDPRLPEGWNKHILKKKGFPGKWDTVIVSPEDKKFRSKTEIAKYLEEHPIEGVNQNLFDFSLVLRRKRKDPHLSAPVRVRVKVKPAPKSPEKDPKEPIPVPVLKEPEPEPTEEPVKEESNANCLKILFEDSAYKCPIEGCGKNFRRENLAQMHVKHYHPEYTKFLDSTPNVADLAYARTVGENLDRSPDDFDFKMESHFLRPQKPPLKPAVKIPTPRSSKQLSFGIEEIPEVKPKLSPISKTKDQEIIKLLNTRPHSHSEPDSPLKHGYESPTVPHFEPKLRDLLMKSEPIPNKDEFDFKPLMRSKPGIKTLLPVHRPPPESTFVEQSEENYRPPVKRKSIYPDSLEIVKGIDQTTDLNSFPSTLPITASSPTVSITSPSLSLQPKISSQAVSSPVAPSILTPPIQPPTPSNDIIIEGGEVIKIVRMRQEEIINCTCGLVEEDGLMIQCELCLCWQHAYCNNIERESQVPEKYVCYICQNPLRERLSRKYYHDQDWLTKGVLPVGSYHTKDEEALQRRFEKLKKCHDLSGALLELGQYQNSLKIKMKIAETKNHPKHYLWSKPWPKANLPEKFKSEMLDIKPKIENDDPDFLKSDFDEEKDAQNENSMLMMILKAGKNVMPKIDLNTLMDNTPIIPQPEAVTDPADCRLNLLEHLVHQCSQVEERLDDFEKQIELLEEGMNIEEDPNCPKTRNTMQLLMRDLETLKEFSQSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKI8</accession>
    <name>A0ABM5JKI8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498452.1">
        <property type="nucleotide sequence ID" value="XM_050642495.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642495.1">
        <property type="protein sequence ID" value="XP_050498452.1"/>
        <property type="gene ID" value="LOC126879470"/>
    </dbReference>
    <dbReference type="GeneID" id="126879470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF378">
        <property type="entry name" value="FI03225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="297" mass="33497" checksum="A972A75BE5420AA8" modified="2025-10-08" version="1">MEPSTFCGACDTHVWYENHELKAGEQIKLFGIDGEDTRTLWLDMRNCSGTLDSASFSLLPNIEYLSMTKCNIESCSEAFSALEKLTSLDFNKTSFPLEAETFKDNKGITNLYLNGVENPKSSCFQHLDKLETLTFESSTFDIINSDTFAGLISLKNLTLEHCKIGSIDVDALCNLNCLEGINIRDSEISEVNLDTFAKLENIKFLSLHHNNIQSDVNYNVFEQLKALDTIHFDTSIYNTLNFDNFPSLHNVRIGYKDDGDEPDVEQLIAKLNAKDIKTEYIFCGTVDCDSDDMEQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKU2</accession>
    <name>A0ABM5JKU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498559.1">
        <property type="nucleotide sequence ID" value="XM_050642602.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642602.1">
        <property type="protein sequence ID" value="XP_050498559.1"/>
        <property type="gene ID" value="LOC126879520"/>
    </dbReference>
    <dbReference type="GeneID" id="126879520"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="357" mass="41213" checksum="23721200AC29BCF3" modified="2025-10-08" version="1">MSKRTLRMLTMANENLVINRSDEIGTLLVNSGDIDEWENLNVDNTPIVMVLDEPQPEDNQTFTTLTTLQNSTELEDFNLTDCLSDFNEIDSLADNDICIMPSDSLSNEMHFLNNNSSADNNSVNLALNNSTNKQVLLPIEQNERVVSLVPYECSSDEDETYEATNTSDVQESSHTGINNNIERNLVNTNSDVEVIMKSKRKLGQNKNEWKRYKNKKLRMKGEVYMGFSKKSGKIKQSMPRKAKSLKEACTSKKCRNSKLRYCKEFTEQCRSHIFKKFWGMTWDQRKVFVASHVFKTPTFKSNKENSRRQGTYTYYLHDGNENLQVCRTMFTNTLDIGYKTIHYWVDGSCSIGFLRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKU9</accession>
    <name>A0ABM5JKU9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498567.1">
        <property type="nucleotide sequence ID" value="XM_050642610.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642610.1">
        <property type="protein sequence ID" value="XP_050498567.1"/>
        <property type="gene ID" value="LOC114335772"/>
    </dbReference>
    <dbReference type="GeneID" id="114335772"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF12">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="669" mass="75425" checksum="9691ED27B24F8350" modified="2025-10-08" version="1">MGCCGSKDESRSEGVTERKCTDVFWLILFILFWFLMIIIAAFSFVYGNPLRIINGYDSFGNTCGTSNNKAFGNMPLSGIDTSEKKYLLFFDVRELKQSLKICVRECPKMRLNTLQDLSSHHRVGIDYCRYDFNYNELNNPKANSLSGQFGPCPSLPIYEGVSVLNRCVPKQVTEVGEAIVSNFYGLLNSWNVVEQVLGDLYSTWKEILGLTFLALVLSLLTISILHCLAHLVSYIIMIGFTIASIAGTAFLWYTYVDIKYHLNQTQKYMLLSESVRNETAFLWYSIIATIITVVILLIIVFMRKKVDFLADLFQETSKCVMHLPQLFIQPILTFAVLLLFFMFWLFVVLCLATASFPEKGEMTRNTAAIVNSSRSGSYASKLVYPSQTDQKEMNLETFADKVKISVVDYVDASWVRGMWWVYFIGLIWTSEFIMACQQMVIAGSVAHWFYKHKYKDESHCCYATGKLIKYHLGSVALGSLVITAFKIPRLILMYLHEKWNRGKSKGNECATCGLRCCICCFYCLEKFIRYLNHNAYTVIAIDGSNFCKAAGTAFEVLTANILQVATINSLGDFILFLGKCFVTAVTGCVGLALFRRDAELTFYAAPTLVVCIFAFFVAHCILSLYEMVLDTVYLCMCQSGDAPDGIKMQNLGVTTNGHQNAETGQLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKX4</accession>
    <name>A0ABM5JKX4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498589.1">
        <property type="nucleotide sequence ID" value="XM_050642632.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642632.1">
        <property type="protein sequence ID" value="XP_050498589.1"/>
        <property type="gene ID" value="LOC126879529"/>
    </dbReference>
    <dbReference type="GeneID" id="126879529"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF234">
        <property type="entry name" value="ZINC FINGER PROTEIN 281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="433" mass="50332" checksum="068A466E0EB6C83C" modified="2025-10-08" version="1">MEIKQEASEETCKIRVEDTCVGSSFDVCKIEIIEEPKREPVYDAFDYLDSNEFSIDTKVEQDEYKFSLVEEKQTTNEESCPQEGNKNNIMETSHSSHKGKYNTCQYVEGKILNKSMNVGSENRPYKCEICFKQFTRKGILKTHLRVHTGEKPYKCETCFKQFGEESNLKKHLRVHTGEKPYKCELCFKQFREVSNLKKHLKVHTGEKPHKCEICFKHFGKVDTLKKHLKVHTGEKPYKCGTCFKQFGQAGTLKKHLRVHTGEKPYKCETCFKHFSEASSLKIHLRLHTGEKPYKCEICLKQFNTTSHLKVHLRVHTGEKPYKCEICFNQFGEAGTLKSHLRTHTEEKPYKCAICSKQFTTKCNLTLHLRVHTGEKPLKCGTCFKQFGQAGTLKKHLRVYTGEKPYKCEICFKQFCKTASLKNHLRTYTGEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLV7</accession>
    <name>A0ABM5JLV7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498927.1">
        <property type="nucleotide sequence ID" value="XM_050642970.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642970.1">
        <property type="protein sequence ID" value="XP_050498927.1"/>
        <property type="gene ID" value="LOC114334891"/>
    </dbReference>
    <dbReference type="GeneID" id="114334891"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF48">
        <property type="entry name" value="SORTING NEXIN-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="93"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="926" mass="104892" checksum="A57BAB8FB0A30998" modified="2025-10-08" version="1">MSLIADVLLNWKIFIVGVGLLTSISIINSAFPLLPVSGVTFLSFSVLIWFGSLCITFFYLHKLLQRNEPLEIIKVSKHHKKEPVKVKPDPKKLDGLVGDIDKYFLSIWYVYISSDAEFTKESRVFLEDVIKRLVEVQSCVHNKVLTHSILNIFLRHLKEYRRGLKRKEKYSGNIEELYRYSHIISTNPKVKNYFVQQLTTNVMRHFINSELWNSLPCQVLVSIIARKLILFLVNFISNPEILNYKLLNLLASNFIREKYNLDKYSRICVSQYYTVVDSTRISEDKLPIEQKSSPTVTSNVQLNENVVMVENKSSEQETEVRKRKNGIVTQQKGKKKAEIPKKVDSAEEVKEEHARTEKPPASAPVKIHEPRLTRSTKTYADTRDLAFGISLGQDPLDALPLTMENMKIKMEHVEDSANLLLIEVKQTTQSTMEGLKSSIKPISDATVHTLHNIKDLQESTMNNALHKIGDFQDEAAGVVEGILDFGRAGLRKGLRLTGLHDNIEQAKASLSMSQSSKNLSKKKSSKTVRSESAERSAVEEESVWINPLQMESPNFDGQILLEKSIEPEKEKREMEIPSISMEEPSSGTTSPDPEYEDAADLASSIAKLRSLLQQRSSESSMSTPALSPILVQARYYGLKFWVADRLQFFQSRPPDELMQKPENDSALDPDEVDGMIPSFYKFCAKTATGVLDKTIHSIKTALPSHVPGVEHSDDAWIFLQTDQSEVDVLSRMKKLLSERKEYCTLDTEIDTAYEAIDSLDTFQHSLFSKSMEFEDELDEFEAKLPITKALVDIACELLSDTDSPLIREPVIKALFLTLGHSVEKYVINIMDLSMDYLCTNLMTIPEFTNNNVLYLEMDVFVESIVASFPDSLKLTFGKTALQKAVHLLVSSLQVQKINEDVILQIFELISLKLIEESSRPYPPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMR9</accession>
    <name>A0ABM5JMR9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499236.1">
        <property type="nucleotide sequence ID" value="XM_050643279.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643279.1">
        <property type="protein sequence ID" value="XP_050499236.1"/>
        <property type="gene ID" value="LOC126879929"/>
    </dbReference>
    <dbReference type="GeneID" id="126879929"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="782" mass="90417" checksum="87CAC24A169492CD" modified="2025-10-08" version="1">MNMNKIKHKYKFRSRTVKLVNEALSTECHSKPLDQSRSSNGSEYTPTCFSDDLDDSYEMHSISIETTDDSVANKQQTDCDLMYENDAILDDSTPNPIYQELIASSSLDNIEKSADETTSSLVCLKKRRIRRKHNCIYCDIPVLNFARHLERIHSDELEVQKYLSLDKKDPKRKYFIDKIRKEGDFCIGKSVPVFRRNVLSNSDESSTNSNMLPCIHCKGYYAKKSLRRHIRRCYFNEKKATGKVRHQSEAQNLMATNFGSTDPLRTSGVLNSLAADDISLVAKKDKLICDVGRKYVKSHKDRHLIQVAKRQMRRLARLLIQSRKIENNSNLTLFFLLHPSKFKTIVSATRSIANYNTESKCFQSPSLALQMGTLIKKAISSAYSMEVQRDVDSANIKSLDVMKKLIDDQWALEISTEAGQNIQINRFNKPTLIPMAEDIAKMKTYLDELITSSITHLDENVNNTQAYKCLLEGTYCSLLLFNKRRVGELQRLPLDIYLKHHDSQSSKEFEKVLTETEKILVHSLKRIVIRGKRGRGVPVLFDKLTKSGVDTLIKYRNNFFTSYNEYLFGIPNTINCISGYHVLRKHASKVLNDANKITTLTSTRLRKHLATIIQILKMEKGELEQLAKFMGHTSKTHDEWYRLPSDIYQTAKVSKILLLAQNTNIDQYKNRNLNEIEVDNEILEDAEEADSDEENTNQPILQQNEVNIPSQNRIKEKGKRILVPWTKEEKELTQKFFARHIKKKIPPKKMEVLNLVEKYPNVFKNRKWDTIKVFVQNKYKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS60</accession>
    <name>A0ABM5JS60_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein DAN4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500778.1">
        <property type="nucleotide sequence ID" value="XM_050644821.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644821.1">
        <property type="protein sequence ID" value="XP_050500778.1"/>
        <property type="gene ID" value="LOC126880767"/>
    </dbReference>
    <dbReference type="GeneID" id="126880767"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24673" checksum="8ADAB58F0FE4DB56" modified="2025-10-08" version="1">MSFLRIGTNNPEYKHVLSFRRHIYVSPPTGPIPDTILITHEDTTNRIFLTLDNLCFICKQHGHISSSCSVNVNHSETAVPTATLSNRNEPSTVTSTETTAITPSTTCTSTIISNNSTPLTKILSTTNLTPLDTSTTDNTMPVISKPNISTSSAPSPHIVITNQPSSSSLSNNSCSVNENKENPAPKEFSVSNEENTSKSSSKRTVSEAISPPIETSASDDIRDKNPISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JST8</accession>
    <name>A0ABM5JST8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501006.1">
        <property type="nucleotide sequence ID" value="XM_050645049.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645049.1">
        <property type="protein sequence ID" value="XP_050501006.1"/>
        <property type="gene ID" value="LOC126880967"/>
    </dbReference>
    <dbReference type="GeneID" id="126880967"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71745" checksum="6B7165627CB0732E" modified="2025-10-08" version="1">MDKSRKLKFQRHTALNDIQSIFDLGNRAVSDLSLRSLFKIRVSEIDLIKDEFLKQHTSIINNVLSVPDSDTGDEEKVRELFLDLFYKIKVFDAEFFGSPSESPGPASCASGGAHPSHIRLPRIDLPHFQGNFINFESFIDLYNSIVHNNAALGNVEKLKYLKGCLDGTPLSLIRNLPITNDNYQVAYDLIVKRYTNVRRCATAHWDAIMGVQKISAVNSKNLAKLVDTFLENLAALKTLGLPTEHWDFIMFNLLLSKLDVDSIKLFELENKSNEIPSFKKLVAFIETQYIAYDNLDSSIGEEKKSSRAPNNTEPKANSKHKTGDSRHNRSSSSFVTNSSSVCCALCKQSHYLNQCSLFLKKSPKERYQFCKESSSCFKCLNQANHSVKSCPKSFKCSKCSSHLHNSLLHFERNRSNSQSSSENNSPGTSGIESSPEVSHCAASFVGNKNETKKEILLGTVLVHAIDSKGCKQPLRCLIDSGSMSSFISRKAANRLGWPKTPCSFEVNGLNSMQTKLNQGQISFSIQPRHQESPVFHLEAIITDRVCSDLPSTQIDISAWNYIKNLKLADPKFNCSQSVDLLIGCSIFSKVWLEGKIEGKPGQPDALNTVFGYILLGPTSTFRQLVLLLRHLFVFQMWKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTR1</accession>
    <name>A0ABM5JTR1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myrosinase 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501328.1">
        <property type="nucleotide sequence ID" value="XM_050645371.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645371.1">
        <property type="protein sequence ID" value="XP_050501328.1"/>
        <property type="gene ID" value="LOC126881229"/>
    </dbReference>
    <dbReference type="GeneID" id="126881229"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046607850" description="Myrosinase 1-like" evidence="5">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55838" checksum="D384E8B6B0ACBD9A" modified="2025-10-08" version="1">MLCIKFIAVIFFILNLGFLDALNNKKFPPDFIFGCATAAFQIEGAWNEDGKGPSVWDTTNHKIPSVIEDNSTADVSCDSYHKYKEDVALLKELGATHYRFSISWPRILPNGFNDYINPLGLAYYKNLIAELKANNIEPLVTISHGDLPQVLGDIGGYYNESFPDWIRDFARVAFDEFGDDVKYWFTINEPHEVCIYDGAEKVYDCAANLLRAHAKIWHMYDEEYRSKQHGKVAMVLNLNWYEPETDKTDDIIAAETKMQFSWGLFGHALYHGDWPPIMKSRIGLRSKLEGYPKSRLPEFTKEEIEYIKGTNDFLAVNSYTTSIIRAIDEPEIGDPTLEKDIGVYEYQRDDWDSSGSIWLKVVPWGMRKLLNWFKQEYFNPEILITENGYSDFTGQLNDPNRTHYLTEYLSAIKDAMDYDGVNVIGYNVWSLIDNFEWNAGYTVKFGLVNVDMNDPNRTRTKKDSFYYYQKVCQTHCIVDQCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU47</accession>
    <name>A0ABM5JU47_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein vestigial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501460.1">
        <property type="nucleotide sequence ID" value="XM_050645503.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645503.1">
        <property type="protein sequence ID" value="XP_050501460.1"/>
        <property type="gene ID" value="LOC126881301"/>
    </dbReference>
    <dbReference type="GeneID" id="126881301"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF15">
        <property type="entry name" value="PROTEIN VESTIGIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34911" checksum="BFA1B544B95E7711" modified="2025-10-08" version="1">MYIMSCSEVMYQAYYPYLYQRAGAAPPVSAHPVPRTGPFTSPFGAAHQYDRFNVQRLQDAHSLSQAAAAAASSSNGSATTLGGGLALPGSLDSSAGHAGVSAGGSHPLYLQGSAHSSGGSVSSTGGGSPTSPLRPGKEEDCSLHGRSSTEDPQPGVDDDDSQEAGSSRAQYVSANCVVFTHYQGDAASVVDEHFSRALDKTSTHTKESSPMSARNFPPSFWNSQHYGGASSSSHHATDLYSDHYHPGDAWYQYSQHHRAVHDYHHHNMAAQYGGLLLPGSRLHMGSHAPCKAMDWQHPSIESPYSSYPTMSGLEAQVQDSSKDLYWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU48</accession>
    <name>A0ABM5JU48_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501464.1">
        <property type="nucleotide sequence ID" value="XM_050645507.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501465.1">
        <property type="nucleotide sequence ID" value="XM_050645508.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501466.1">
        <property type="nucleotide sequence ID" value="XM_050645509.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645507.1">
        <property type="protein sequence ID" value="XP_050501464.1"/>
        <property type="gene ID" value="LOC126881305"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645508.1">
        <property type="protein sequence ID" value="XP_050501465.1"/>
        <property type="gene ID" value="LOC126881305"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645509.1">
        <property type="protein sequence ID" value="XP_050501466.1"/>
        <property type="gene ID" value="LOC126881305"/>
    </dbReference>
    <dbReference type="GeneID" id="126881305"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028413" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="719" mass="81775" checksum="631CE8022C238376" modified="2025-10-08" version="1">MKIGSIVIVVCAVLTGSLAVQKHNAVKIVDALVDTDEISPKCLESLKLFAYRLNTIGSEEDLWALKMLDATSKMPVGLLSYNFGEMGNFKQCIETVSQRDHIKGKYCLGNIVINTTAIDYSAITRNYAYIKRLISKISDGVHMVGYPTWALCLPSNCTDEDAKYVMSRSQTLGTGIDSITCQTIEDVNPPLDYAAIIGLSILGILFLVVIMSTIYDLYCQNKYKEYQQSAYTAFSVYTNGKKLFQVSKRVSPLSCLDGIRVISMIWIVMLHTYSVYTTGPVFNSKDVVNLSNSLISMVFLNGSLACDTFLIVAGTLVTYVFFKKEKSSEINVSSVAKHYFHRYMRLTPALAGVVLVSATLLKYMGSGPRWPLFVQFFQGFCTQNWWTSLLYIQNEVNVDQMCVGHTWYLDVDMQLYILSPFIYWMLRQYTKTGLALLIVGTLASISIGFFRAFEDELSGLQTNYYAKTPFNVYLNEYYLKTETRAAPWLIGTILGYMLTRKTFRDSRISKHIVVPMWCLSLTVMLLCVLGGHSTLRGPEYHRLENAFYIALVRPSFALAVGWIIWACATNHGGFINTALSHGVFQFLNKFIYSIYLLHVTCLYMIMFAQKRPLYMTIFNLVYWFWGIFMLMFGLSIIWVLVFESPMIVLEKIIISKLKKLGSKSKLNNQTVCENMKRGLSLYRENCFTEDPRVINIPKICPETKPVTCQEEVRLYEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUF4</accession>
    <name>A0ABM5JUF4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase BRSK2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501570.1">
        <property type="nucleotide sequence ID" value="XM_050645613.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645613.1">
        <property type="protein sequence ID" value="XP_050501570.1"/>
        <property type="gene ID" value="LOC126881375"/>
    </dbReference>
    <dbReference type="GeneID" id="126881375"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39853" checksum="D3C330D7E686D6C0" modified="2025-10-08" version="1">MSSPVSQRPSSHHTHRSSTHVSSNTHVTVTPPPATPTHHRANSSGGAPVSSGMSLTSPESDTTSLVTGPSILTPMTPPGSPHSSTTSHHWRSRLTTIKNSFLGSPRFHRRNKLQASSEEVHLTPESSPELTKKSWFGSLMTTEKDETFTILVKGKPLATVKADLIHAFLSIAELSHSVSSPMSFRVEYKRGTTGPAMFQRHVRFQVDISPIIKQSRDNTKEHLFAITFTLLSGNIRRFRRVCEHIQAQVCTRRPPPSPRAQRKFTTELSESSSCGSDSSELFLNTRQLNVLQLENSDLESECSVFDVRTATREVSRRASTNNNTETCEQNSPGTPKAVRSNSENTETCEKKCITTMSGSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYK9</accession>
    <name>A0ABM5JYK9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503024.1">
        <property type="nucleotide sequence ID" value="XM_050647067.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647067.1">
        <property type="protein sequence ID" value="XP_050503024.1"/>
        <property type="gene ID" value="LOC126882243"/>
    </dbReference>
    <dbReference type="GeneID" id="126882243"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="170" mass="18790" checksum="60E039E5815818FA" modified="2025-10-08" version="1">MLFLGVYYKTESEKKFKSACDQVRKFSKRPPDNDLLELYSLYKQATVGNVNTAKPSGLEDVKKWEAWNAKKGIAISSAKEQYIAKAKVLAAKPSGLEDVKKWEAWNAKKGIAISSAKEQYIAKAKVLAAKPSGLEDVKKWEAWNAKKGIAISSAKEQYIAKAKVLAGTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ36</accession>
    <name>A0ABM5JZ36_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503195.1">
        <property type="nucleotide sequence ID" value="XM_050647238.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647238.1">
        <property type="protein sequence ID" value="XP_050503195.1"/>
        <property type="gene ID" value="LOC126882341"/>
    </dbReference>
    <dbReference type="GeneID" id="126882341"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF234">
        <property type="entry name" value="ZINC FINGER PROTEIN 281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="605" mass="71583" checksum="D3343B1D2D26829E" modified="2025-10-08" version="1">MKRHLRVHTGETPHKYEIYFKQFGQAGSLKRHLRVHTIEKPHKCEICFKQFSREDYLKEHLLRTHTGKKPHKCEICLKQFSETCSLKRHLKVHTGEKAHKCKICFQQFSHASSLKRHLRVHTGEKPHKCEICFKQFSETCSLKRHLKVHTGEKLNKCEICLKQFSAAANLKRHLKVHTREKPHKCEICFKQFSDAGSLKRHLRVHTGEKPHKCEICFKQFSETCSLKRHLKVHTGEKLNKCEICFKQFSLAGNLKRHLKVHTREKPHKCEICFKQFSETCSLKRHLKVHTGEKLNKCEICFKQFSLAGNLKRHLKVHTREKPHKCEICFQQFSHASSLKRHLRVHTGEKPHRCEICFKQFITARDLKLHLRVHTGEKPHKCEICFKEFGQASSLNRHFSVHTGEKLNKCEICFKQFSAAANLKRHLKVHTREKPHKCEICFKQFSDAGSLKRHLRVHTGEKLHKCEICFKQFSDAGSLKRHLRTHTGEKPHKCEICFKQFITAGELKLHLRVHTEEKPHKCTVCLKQFRRIVQLTGHMKVHTAEKPHKCEIFFKTFSHLRFLKDHLRIHAREKLYECEICLEEFSEPRNLKTHLKVHTSEKPYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZN1</accession>
    <name>A0ABM5JZN1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503398.1">
        <property type="nucleotide sequence ID" value="XM_050647441.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647441.1">
        <property type="protein sequence ID" value="XP_050503398.1"/>
        <property type="gene ID" value="LOC126882476"/>
    </dbReference>
    <dbReference type="GeneID" id="126882476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="59206" checksum="AD0E1244C9B2EDE5" modified="2025-10-08" version="1">MSCSLDQLSSYLDDNQKNITRRYFNDDSKFNLVKRKGIFPYEYLDSWEKLQVTCLPSIDDFYSKVNNEGITKEDYQHACNVWTRFQIKNLQEYAELYLKTDVLLLADIFENFRSMCLKTYGLDSLHYYTLPGLAFDAMLKVTNIELELLRESEMVLFFEKAKRGGVSQCSNRYGEANNKYMKDKYNPDKEVSYLIYWDFNNLYGTAMSYALPYAGFEWINLTDIYKENILDCPNDGEYGYILEIDIEYPKELFNLHKDLPLCPEHIIPPSSNSTIPKLLTTLYDKKKYVIHYIYLKQIVSLDQAKLLYTDTDSLIYQFFVDDLYKHIKEDIDKFDTSDYKEDNVYCIPVRNKKVLGLMKDENQGELMTHFIGLRSKMYTMKILNQQAEIKKAKGIKKSALKELSYDDYYASLFNKPLIHRALPASGVGVLKIKEEILSDEDFNYRKNYNAQIPDDHPLHRDDLIWARYIDQVTWSYWMDIKTTLWNDIAVYHYYELNYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1X1</accession>
    <name>A0ABM5K1X1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504186.1">
        <property type="nucleotide sequence ID" value="XM_050648229.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648229.1">
        <property type="protein sequence ID" value="XP_050504186.1"/>
        <property type="gene ID" value="LOC114334390"/>
    </dbReference>
    <dbReference type="GeneID" id="114334390"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21205">
        <property type="entry name" value="CH_LRCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF21">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="565"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="721" mass="80694" checksum="0B07598E14868BAB" modified="2025-10-08" version="1">MAVLVSNISGHIQNQLTRSLERILEEANQSGELKLSNRKLKDFPKSNDKYNLSDTVIADLSKNRFCELPEEVLSFHFLEKLCCYHNAIRFIPDAVSSLQCLNFLDLSRNQLTSLPRELCQLPIEILLISNNSLSSLPDEMCRMSQLTELDASCNQLTHLPPRLGELKSLQSLVLRNNLLLAVPIELTYLKLVRLDLRANRISNLPIELRNISCLIELLVDDNPLTSPPASLCKRGRVHIFKYLELEALKFDRRPDSNGGTLGRRPRRSGAGSSPGPLHLTDRLKHKRHNVDSGYSTSSDCYDKRWSQEITIRTGDQNGTQSTLSTPSTLSPAHESNNDEEVGKVNELDKVDGLKSREYASVRLSPCPDSFSNSNGTDDRKPLHQIQTYREYKEALKQQRAQDVPSIYRTKDDQSYKTEPNTPTHHVAPSQTLATSRSDPTPLNSAFSNPKTIFDDTSPTKKPVQKVQPSRTYSPIHMNGVSDNRNGSPKISNYVKPKSPMKGSSDIMSHDNVPTVKSVITNGKSSPKLGFHSTPRSPKTTKSISWNHDANNDKLSFTMRREIDKAKEETDLINQLRNVIESRLKMALPEDLAPALTDGVVLCHLANYIKPRSVASIHVPSPAVPKLTMARCRRNVDNFIEACRKIGVDEEHLCSSLDVTEALCGRGLPRLVETVEHLCKFDPYLQHRPAKKPSLQDTTVSLLLLAVFFGTVAMLIAFPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1Y5</accession>
    <name>A0ABM5K1Y5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504199.1">
        <property type="nucleotide sequence ID" value="XM_050648242.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648242.1">
        <property type="protein sequence ID" value="XP_050504199.1"/>
        <property type="gene ID" value="LOC126883050"/>
    </dbReference>
    <dbReference type="GeneID" id="126883050"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="65" mass="7403" checksum="8FFFF9AACD71F240" modified="2025-10-08" version="1">MSMPAFCVSSKSHPNSSLSATNNLHHRAIIQHSQTCEDLDKEYDVEQSSKWAMPVICTQKKNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2K8</accession>
    <name>A0ABM5K2K8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rabankyrin-5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504422.1">
        <property type="nucleotide sequence ID" value="XM_050648465.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648465.1">
        <property type="protein sequence ID" value="XP_050504422.1"/>
        <property type="gene ID" value="LOC114332941"/>
    </dbReference>
    <dbReference type="GeneID" id="114332941"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF191">
        <property type="entry name" value="RABANKYRIN-5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="467"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="831"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="870"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1129" mass="125099" checksum="28D9775B730FFAD4" modified="2025-10-08" version="1">MAGSAAEVTKLQQHLLLLKQEFSKLQSKYRDIEIKYNNVVASDTNNTEDTFASRLLKIISNLYNSEAYSDIKIKLKDKEINAHKIVLSARSNVWNENILNHTKELDWSEIDAEVANAIVLWLYTNKLNLLSTTVTLNLIKKAHEFQLHSLVSMCEQFLISAVDIRCCVKFYSVAEEIEAPSLREYCSEFISIHWDDLDSSDFEHMSGPLMYKMLKDKTTLPLHSAVRLQREDVVFLCLVDNSSNIGKVVNSRDVNDELPLELALRSRNESIATTLVQHNADVNILDSNGDTLLHKAIKKEDFFSAQFLLEQNCDATLSTRSGNDSALHLIAGAADIENSVKVAEKLINKSININSQNSHGFTSLHIAIQADNKPIFHLLLQQGKINVNIETNKGHTPLYYALLKYESGDDEDDSYAKELLKHGAETNPIYSSSYTNLLQILILEKAQKAAVFLCEKVSEHINHVNSKGETALHLACSANFDDLVRCLTKLGANPNLLTNEERQSPLHYAVKNNAEKSIFALNDYNNDLEKSKNSPDAQLICNFNQRDIEGETPISLALNEGFSHLIPTLIKGKADINIRNGKDFTLLHQAIIKQNSSMALFLLNHGADINAVTTDYETPLQLAIHCRLGEVVDALCTRGVDMSAPDRLGSCALWTALDSGQEDIASILVKHGADTDCWGDGPEGCRQTLLHRAIDENKESEAIFLIHAGCDLNTPRIPGPNGEGGDEAKDKRSPLHLCCQWGLEPVVRTLVEHRANVNIRDAENKTPLHIAIESQQEEIISLLLSVPEIDLSLRDKAGLSPFATALTFRNNKAAQAILDKFPSAAEQFDSKGQNFLHIALKKGDIESALFLLTVQVDVNSRVQDPMLTPPIHLAARHGNETLVRSLILAGARVDDRDAQRRTALHAAAEAGNHSAVLALIQNNSDCDATDVENDNAFHIAMREGHLNVVKVLLTESYIDVEAVNLKGRNPLHELCKYGKDNAATICGLLLECIPTYPINNPDILGNSPLLLAYINGNGSLCRVLVKANACLSSENSERVTIFNYQVPTKQLLNRLLDTLSEPAPWTNTDSCQECGKRFTLTVRTHHCRHCGRALCSKCSDTEVPIIKFGENKPVRVCKVCFDVLKTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4M3</accession>
    <name>A0ABM5K4M3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">27 kDa hemolymph protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505139.1">
        <property type="nucleotide sequence ID" value="XM_050649182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649182.1">
        <property type="protein sequence ID" value="XP_050505139.1"/>
        <property type="gene ID" value="LOC114332851"/>
    </dbReference>
    <dbReference type="GeneID" id="114332851"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20997:SF2">
        <property type="entry name" value="EG:BACR42I17.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047473046" description="27 kDa hemolymph protein-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41022" checksum="DAD6F30FC36A1750" modified="2025-10-08" version="1">MKILGKILVILFIGYSNTQNNDFNRFDTQGIDFANLDRRINGIEENPPNTQGLNFKPYESFDIKQFDNSVTFDGRRFWEDVPTDPDAYLAYLHRECDKSGHPEILNMDNEVYRQAKVCLGSRADYIKTTVRQFFNESGLSAIRQIDYKEACKVWPEVHNCINPLVSSIKQCLKSDVQKIFDTFLEFIDVSQSFFCDNNADRISSLVSDGSVQCFSLVDKDLKECQTNFKKKLGDSINAINIWGDVDSYKVMTGKNLADETCSTFKSYRNCITSKLAKCKSKYTSKIADDYLALVQDELKFCGSPRWFPSTNAMIFIGLGVVTINCILFLGFRALGARIAKKRQQLCSSRITASGQIPYTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5S2</accession>
    <name>A0ABM5K5S2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505537.1">
        <property type="nucleotide sequence ID" value="XM_050649580.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649580.1">
        <property type="protein sequence ID" value="XP_050505537.1"/>
        <property type="gene ID" value="LOC126883883"/>
    </dbReference>
    <dbReference type="GeneID" id="126883883"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046692127" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="234" mass="26553" checksum="D493FE7DFABE1604" modified="2025-10-08" version="1">MIALKLLAIVAMAFLAEASDLDSGYRIMSCAKRAITNGVPELNIPSHSPVYITRNFSWSGDIGVASASFDFHDFIWDGLPQWNLTATQINKDSDPYAVFDFDLSWKWMNISGLFNVTIRELVLEQHYNGNIQFEWTNSHWKGRINVTKPYFNLTQEVNDAQIKWTVEHLDTTVKGLGIWNGPVEATFGTGIITALNSGLIGNTVGEFIKMRLNTIWWSTGKIWDLVHWCYDSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K688</accession>
    <name>A0ABM5K688_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505708.1">
        <property type="nucleotide sequence ID" value="XM_050649751.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649751.1">
        <property type="protein sequence ID" value="XP_050505708.1"/>
        <property type="gene ID" value="LOC126883981"/>
    </dbReference>
    <dbReference type="GeneID" id="126883981"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26858" checksum="E23DFC80719E9D91" modified="2025-10-08" version="1">MDIEGLGQYLVFNRAIEVQTPQQPLTEGQQQSVNWTTNHSKILLDIYNQYRGKVGTFQIKTFKKLWEIMAQEINAVAGTNFSAGHCENRWRVLERAYKKFIDNKNKTGRGKKYFEYEAEMNEIFKGKMNIKPEVTITTESFQQEPVLTPEAVNEPVASTSNVPSTSEKPKETGRHKKTAVTRIAIMQQMQIDRKAYYDKRIELEQEKIKIQREKLKELKERKCSECLKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6D1</accession>
    <name>A0ABM5K6D1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050505746.1">
        <property type="nucleotide sequence ID" value="XM_050649789.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649789.1">
        <property type="protein sequence ID" value="XP_050505746.1"/>
        <property type="gene ID" value="LOC126884014"/>
    </dbReference>
    <dbReference type="GeneID" id="126884014"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="6">
        <location>
            <begin position="29"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="7">
        <location>
            <begin position="419"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="8">
        <location>
            <begin position="562"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="678" mass="77213" checksum="D839FF6FEAC56AA1" modified="2025-10-08" version="1">MALEALPTLYGYYTDGGITAGLSDKQPYFTLNNKNITIYSGAFYYFRVPRAYWRDRLRKMRAAGLNTVETYVPWNLHEPQSGVYDFGNGGSDFEDFLHVEEFLKFAKEEDLFALVRPGPYICSEWEFGGLPSWILRNTSSVRNSKDQNYLSYIKRYFNILLPLLALLQFQMGGPIIGFQIENEYGNTGNDDVEYLKYIQQIFEDNNLIELYFTSDSPSVNGRGAIPGILQTANFNSNPKWQLDKLNQLQYNKPTMAMEFYTGWFDHWLEDHHTVSSQQFKSLLEEILDYPSSVNQYMFVGSTNFGFTNGANSRKSGMDNTGLQPTTTSYDYDSPITEYGDYTEKYQIVKDAIAARNPVITKLPDQPKVQPLIKYESLQIEGQLTLADIINSEIQSGENVIHHTGDPIPMEQLPINNNSGQSFGYIVYRHTHAAAGAVKLTLTGTVRDTLLVLVNGTLITPVPSKKSDVDGVGFWRLVNTSLDLQTDTNTPETTYVIDVIVENMGRNNYGGLDQFRQFKGLADSFQVNGKNMTTFDIIPLEFKKSWNNALKNWQSLTSTQSTPALYKFKLNINNYPQDTYIDSTQWTKGITIVNGFVIGRHFFVGPQQSLYLPAPFLNKGENTIIVFENYNAPDELTFVDHPIFQSRGNSYNSRAIKKIKTIKIYSCYIWLSLYSLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6J7</accession>
    <name>A0ABM5K6J7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505804.1">
        <property type="nucleotide sequence ID" value="XM_050649847.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649847.1">
        <property type="protein sequence ID" value="XP_050505804.1"/>
        <property type="gene ID" value="LOC126884058"/>
    </dbReference>
    <dbReference type="GeneID" id="126884058"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="370" mass="43980" checksum="E8B03FEB55A0BAD9" modified="2025-10-08" version="1">MEKLKFQFTIQGSADGKTNEICITAIETPDGRVFELPEEFKQVNKHTYLAKSNVFMKVKNSLKKRGQKRNLWVPLDIEMRKIYLDDGENLQFGEQYLDEKTQSVVATYEKEIPSIKNLSRVTESFLIEKFSIKIPNACQWMEDFERECERFEIIDDEQKIESLKYLLEKQCLDWYSSMIIKYTVQSDWKIWKTNFCDAYEKKGWSQIKYAFTFKYQSGSLIEYATKKERLLLEVNKTIDNDTLINLIVLGLPDDIMNKLDKYSLISTTHLFSELNKNEYLVNKQGKRQKVFLDFKEKVEEKQYKTSQRLYKEQKHICSICEKLKKGTRYHLESACWYKAKDNHNDKDSQIQLINNSEIECELQNENQKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K752</accession>
    <name>A0ABM5K752_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506017.1">
        <property type="nucleotide sequence ID" value="XM_050650060.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650060.1">
        <property type="protein sequence ID" value="XP_050506017.1"/>
        <property type="gene ID" value="LOC126884195"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="602" mass="69174" checksum="8C99AB60DB69C58A" modified="2025-10-08" version="1">MPKLRKYDKNKLIEAVKDVQNRTESYRTAEKKYGIPKSTIEFKLKHPEHKDTLGPSPILTCEEENTLVRWIQETASKGFPKKANDLKSSVQKFLTENPRPNNFKDNRPGDGWLKGFLKRHPEVSKRTSEGVTAASACVSERDIKNWFKNIETYVKEKHLEEVLTDPSRIFNGDESGFQICPSTGKVFAMKGSKNVYNVEKSCSKENVTVMFTFSADGKICVPMVIYPYQRIPEKVAKGINPKWGVGRSDNGWMTAETFYQYIANVFYPHLIENNIKLSVILFVDGHKSHLSYQLSLLCNELQIEVIALYPNTTRILQPCDVSIFRPLKEAWRQSVREWEEQHPGGVVNKVVFASILEQATKKSCKTETVVNGFKVCGLFPFKADAIDYTKCLGKEVVRNLIISDHQKKPKMDYNTFVNILGPEKVHSLENLKENPKNNLPSDDNLNLLFKIWNFFEHDPQHSDKQMVLKNRDTNINIIQNIAITSPVKNTEIKTSEQSGIENVNISESSSTNDIHTQQYKTNVYDLPSTSKIIVKHEFLGNFLTSPPVPERKNKRNTERLPFAITSARYQEMLRKKEVKRRAGKTKTRKETEKRRKINQEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K934</accession>
    <name>A0ABM5K934_DIAVI</name>
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        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506696.1">
        <property type="nucleotide sequence ID" value="XM_050650739.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650739.1">
        <property type="protein sequence ID" value="XP_050506696.1"/>
        <property type="gene ID" value="LOC126884668"/>
    </dbReference>
    <dbReference type="GeneID" id="126884668"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
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            <end position="322"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="322" mass="35061" checksum="3DFEA4D51651A0D0" modified="2025-10-08" version="1">MDYDAVANNVIMNQLCKVCGEPAAGFHFGAFTCEGCKSFFGRTYNNISSISECKNNGQCVINKKNRTACKACRLRKCLLVGMSKSGSRYGRRSNWFKIHCLLQEQQQQQQQAGSNMVAAANLLRPHPYLSPLFRNPGITTQHTPRDTSRSSESDSGASSADPEDDLRSNSALSFLKSSASPTSDREFYATKKLPSPSSDSEFFARKKIVSSALNNIPPVSPASLPSVSPSEVVPKWLPPLQGLGDPSAWKDLWRAPPPVAAPAPDQDQPIDLSVKTQSAVGPLSDQSEESDQELNIDVGIDEPLKSMPLDLTLDRQVTDVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAX7</accession>
    <name>A0ABM5KAX7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507349.1">
        <property type="nucleotide sequence ID" value="XM_050651392.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651392.1">
        <property type="protein sequence ID" value="XP_050507349.1"/>
        <property type="gene ID" value="LOC126885003"/>
    </dbReference>
    <dbReference type="GeneID" id="126885003"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046843814" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="124" mass="13728" checksum="34BDBBD120506256" modified="2025-10-08" version="1">MVRAFHILATLLALQLSYGNPQPGYPVDPHFPPEDCEPYPVHCPYPIPEPVCEIPVIPPPHCPNPIPDCDYPYPGYPHGPINPGPLPPHLPLPPHLPIPEPCVGLPGSWPNEWPCYFPCGWPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCJ6</accession>
    <name>A0ABM5KCJ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507900.1">
        <property type="nucleotide sequence ID" value="XM_050651943.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651943.1">
        <property type="protein sequence ID" value="XP_050507900.1"/>
        <property type="gene ID" value="LOC114338582"/>
    </dbReference>
    <dbReference type="GeneID" id="114338582"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="2022"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1280"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1337"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1764"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2271"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1337"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1359"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1374"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1420"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1462"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1764"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2271"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2294"/>
            <end position="2308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2308" mass="254033" checksum="BF3736A1B3119438" modified="2025-10-08" version="1">MTVAYKTIRSSVKTRKRKPSETEAPSTKPRNFIAKEDLENKQTRRRNLTNRSVNKKKVLEEANNAKLREIEIRVETCTTLSLLCRQKLERELAEQQAEEDGNNHPETPQLSPIDKSEPEPPTLPDPSPVDGEVSNGSSNSNSVELVSVSVASDNVQCESMPTEKEVVNGDLNESEEDCVIVAQTRTIITSNKRVEQGDCSIRGDDDVPLVSSSPSPYVVHRMDLGGVVGGVSDASSASSSASQCAGLLLRFPDDRSDSGVSSLRSCISNSGDERSGSRSSALSSTDEPTSSSLSSSSSSSSSSSSSSSGNGGSNINVGVGSNVAVASSVSPQSLLSSVSISSSTAGGLQQQRSHSRSPLYIPASTSSVQQRHHEVRSEPVRVWRDPNLLLEEPHVRHIHSVQHQSLLMSHSNTPASASAGPPPPSSSVASVAAAAAAAAAQHPSASALGAYPVPPPPSLMAPHVPLTSHHPHLAATHALYHHTAPFTEMLWKSSPRTHSAYGVPTHMLAAAQQSSHSAGQVTSPEEMLAERALALQDRERMYRERQNQEMEKQKEKERIERDKQEREKLERERQEREKELEKERQEQALHNHFEKSLRAAQPKREPWNPITGRPTQPRTSSMSEDDRKRVEEMHHREQQQRHMSVRDNRDHRSYYAPIQRTTTSIPPPPPAHRSVSSKSSIEKVPAISVHQTMPKTELNIYGYHPSLHSQNTFFEPKIKSEMHKTQTGGLVVTKTGQLDRDGTAMVSELKNSVIVKHEAKNPHHLETRVSVAHSPSPKLRNEMLGHYQCPTGQKSIYEYRSPNQSPHLSSHTASPHHHVEAQNLGKAASHHRPTSSHVSSPHHQRQSPHQHPHSQPHQNPEMRYRAGSENQAMLYQTSAKASYPFTTAGYTMISSATPTVANSKPKVSSPAPHQIFGKPPIGGSSSMIPVTRPSHENTSPISLTAKPPLSSSISPSPYQQVSQYHPLHNQPPAVMNCPPPPAHSRTPITTSGVVDRFDRSTPGYVPAGLSVKLVGPGTSPPTATSAPLQISRTHPQFQPNMVGISQVQTQPLDLGVSSSKMENYQAVSPKRKSSTPLSIPGDLGNPVCLDVKKRKIELGPSVSPMGTSLSPMGTSASPPTLNIFNNSSIQPQLSRVTEPSPLIASAATTITTVVNTAAYRTPPTTMISQTPTVLPENLPDVSVTAVTIEPPRPISIGDQSPKPPTPTVPVSNSPAPVSTASTPTPPTSVTPGPTDEQPGTPVKVNPSVIDSEKSNSPGPIKSSSSGSYPVRHLKKAWLQRHTGEDAEDTTGVVGSGSCVTLPLNIKTTTPPPAPVRENPVNSIHSIGTMAVNSINKAKHFTNKTANRKVTKETTVNGDTKNDDSSSSDQDRGRKSPPKRKPPKVKRKKGGGSAVKKAVDEKKRKSGPQATPTAPSESGSDSEKESGSDKDSDSGASGSAHAKKSVNLVGKEQRKRGRKPKGSKNDKSEEPRPKKIKEEEIPPQRDPFRKPPVGQLKKTGESFLQDGPCFEVAPKLAKCRECRWTPNQRSKNMANIFCRFYAFRRLRYTKSGQLAIAGFSDPHKDALEEDVRLWLPNADNAPTDLDLETSRFLLKQVGDHFCDLLVQEKEAHSEHLADDKTIAWKRVVQGVREMCDVCETTLFNFHWACGKCGFVVCIDCYKGRKRGTIKLWVEANKDRDEYSWLLCTNRQVHEQEKLMLTQIIAGDSLIKLGKMVHEMRELWDIEQFCECPASKEVKNNNQQVKEVVKALLGYYNVNGVKKKIKDERESGPDHEIKKEVSSSDDEGNFSTLRELLIRPSHKPNGSRAASPIIKNESKKKISPSKASDLVDDAIASVIEDSVAAQNPAESRELKHYIRRYHWQQKGRGQLPIRIMTLTESKLMYPNTPHSWLCDGKLLRLSDPGSLENYKIFQDQWGRGQPIVVSDVTRNFNAELWSPESFARDFGDEKNDLVNCMTGKVLPNQTMRKFWEGFDHFTKRLKDDRGHPLLLKLKDWPPGEDFAEVLPTRFADLMKVLPLPEYTRRTGRINLASRLPDCFVRPDLGPKLYIAYGAPLHPSKGTTNLHLDISDAVNVMMHVGIPKDVDADENIKEAFRAIDEAGCDILTRRRVRDKGGLPGALWHIYNARDADKIRDLLNKVVIEKGGRLEPNNDPIHDQSWYLDGPLRERLYKEYGVEGYAIVQCKGDAVFIPAGAPHQVRNLHNCIKVAQDFVSPENVAHCFHLTQEFRDLTETHSNHEDKLQIKNIIYHAVKDSLSSLSAIINSHINVKGEKDIKAEKDIKTEKDAKSEKDSSSSERSNGSTSNDAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCN2</accession>
    <name>A0ABM5KCN2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507953.1">
        <property type="nucleotide sequence ID" value="XM_050651996.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651996.1">
        <property type="protein sequence ID" value="XP_050507953.1"/>
        <property type="gene ID" value="LOC126885426"/>
    </dbReference>
    <dbReference type="GeneID" id="126885426"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="213" mass="25797" checksum="000601273975C710" modified="2025-10-08" version="1">MSFQKEQIIEIKEYTKELIAANGEEMMKETRDLIREVKEMNQMYKDEIKRLIEENLQMKNEIKKIRAKMNYIEEVENRIETNDRENRKNNIIISGLDIPNINEKEIEDHVKNFVDKELKVAINNAKVRKIKNKTYLVKVDNFSKKLEIMKNKTLLMKGEYKQVYINNDLTLKERAIQNKLKIIAKKKRRKQESKNRISKINNQWREMDMEYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCS9</accession>
    <name>A0ABM5KCS9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serrate RNA effector molecule homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arsenite-resistance protein 2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507996.1">
        <property type="nucleotide sequence ID" value="XM_050652039.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652039.1">
        <property type="protein sequence ID" value="XP_050507996.1"/>
        <property type="gene ID" value="LOC114341913"/>
    </dbReference>
    <dbReference type="GeneID" id="114341913"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="9">
        <location>
            <begin position="118"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="8">
        <location>
            <begin position="255"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="369" mass="43079" checksum="EE97111B9D7928D8" modified="2025-10-08" version="1">MADSDDEYDRKRRDKFRGERAEASYRGAERVARPRDEWAERDSWSRPRPREYRSSVRDRGYSPNMEPAPKRIRHDYYGGGGGDGYYNHYGVNTYHQPAYRESMGAHTEGQQPPMMSFKAFLATQDDNISDSEAIEKYNDYKLEFQRQQLNEFFVAHKDDEWFRLKYHPEESVKRKEEQKAALKRRVDVFIELLNAGKIECVKVDCAETNKLLKLLDTVVIKLEGGTDEDLAALEQEYEGKITLLLMRLNLNLVLGPDFVRKHIFNKHAEKLVEVRKEVEFFNNYLKDPKRPMLAEAPQQKREEPASYPHMFGGGGYGGSGYTRPAPFYNQSFVPRTRGYQPRGRGGPTDFRPVIHYRDLDAPREPEEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCU1</accession>
    <name>A0ABM5KCU1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508007.1">
        <property type="nucleotide sequence ID" value="XM_050652050.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652050.1">
        <property type="protein sequence ID" value="XP_050508007.1"/>
        <property type="gene ID" value="LOC126885476"/>
    </dbReference>
    <dbReference type="GeneID" id="126885476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1100" mass="128420" checksum="D0A2F92F99655AE0" modified="2025-10-08" version="1">MNTCSRCDKSYSRSDNLSRHIKKCKYGNVDSDKNGDYYIPKKRLRPLGVEVIDSTVSKLSHAFKNRIASYRFSGDKKLDYHGFLNDVKPKVLNILSEYLHQHNSIKVNFEIFGIYLKPDTNLSDIKSMNTCNKIITISTELDEVFDDFKEELMTQASEFQEKDSNWVLQEIMFLDVNINKFSSISASTYIRLPIPIVRKHAILNIENKDNKCFAWSIIAAIFPASGNPTKPESYPPYDTLLNFEGIEFPMKLKDIKKFETLNNISVNVYGLESNFVNNKRQYEIVGPLHFTSNRHLTHVNLLLITNDKQSHYCLILDMSRLVKSQKTKNCRKEYLCDGCLQFFDSEEKLHNHQNNDCSHIYTELPTTKHKINKFGEMVPENILKFINIQRMLPVPFVIYADFESLLKPIDHAEPFNGNSYSVKTAEHQAYSFAFYLKCNYDDSLSKLIKYEGQDAPKVFIQKLDDLVHELYNNHLKHIKPMSPLTKEEIEKHETATECYLCGKPFNPFNRKVKDHHHLNSLYLGPSHNSCNLNNKLSNTIPVFFHNMSNYDCHLFIKELSTTGEKVSVIAQTKEKYITISKKILVEKSKNGLDKYITLKFVDSYRFLAKSLDILSTTLNSEQCTEIRKYFPNTKHFELVRHKGVFPYSYMDGFDRLKEKTLPPKENFYNNLTNKHISDEDYARAIDVWNTFDCKSMSDYAMVYLVSDVLLLADVFENFRKICHKEYNLDPCHYITAPALSWDAMLRYTEIELELLTDVDMVHFLKKGVRGGVAQCSKRETVANNQYVPNYDPQQPKSYIMYLDATNLYGAAMCQYLPYGNFKWVTDVENFNCFSVEDDEDKGYVLEVDLEYPAHLHSLHNDLPFCPESMVPPGSKCPKLIPNFNNKTKYIIHYRNLKQCLRYGLVLKRIHRILEFSQSPWLKKYIDLNTSLRNKAKNEFERDLFKLLVNAIFGKTLENVEKRRDIRLCTRWETKTRSLGARVLISKPEFKSCSVFNENLVAIHLGKTKIVYDKPLYVGFTILDLSKTVIYDFYYGYIKKKYGEAANLLYTDTDSLIMEIYTPNFYEDMKRNLEHFDTSNYPTDKYSQDSENTINTRKNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEG8</accession>
    <name>A0ABM5KEG8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508585.1">
        <property type="nucleotide sequence ID" value="XM_050652628.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652628.1">
        <property type="protein sequence ID" value="XP_050508585.1"/>
        <property type="gene ID" value="LOC126885857"/>
    </dbReference>
    <dbReference type="GeneID" id="126885857"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="352" mass="41027" checksum="02C0E49F7C4BC33D" modified="2025-10-08" version="1">MFVIIVRSTLKLVYFLLSRKSCYICSFCICEIKKVELCMHVRLILKKLKLHLWLFWVYAACILLFLLFLLPYLLKSTTELLSGSNLIAHKIIKFYNILISYISFFYGTLETYKEFVEEMPWVVLRFPESETIEAVPAKWYDKANKLCKFPPVDDHTEKELSNFIIEEYDPLEEWPIHEAVLESQTEFVLFNKAHIRASKACNSQNYKSDKETVLPQKRPPKPRKIASSSSEQDSDGSDLVFEHSFPKSKKEQHEKCTPSKSRTHPNIGLENKQEVKTVQETSKPTPTNANAQETAISYLIRIKRTLELQEQKLSEIDRKVDELSTIIRGQQKSTDITDDEVHKKLPLSTFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFW2</accession>
    <name>A0ABM5KFW2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509091.1">
        <property type="nucleotide sequence ID" value="XM_050653134.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653134.1">
        <property type="protein sequence ID" value="XP_050509091.1"/>
        <property type="gene ID" value="LOC126886264"/>
    </dbReference>
    <dbReference type="GeneID" id="126886264"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="477" mass="55978" checksum="B50A6CAB5DC99C09" modified="2025-10-08" version="1">MNKTNSKKPKGKNNDDQRQKDNDDALISKIENREEQSQDGTIDEDELRKFERELLQRHDQQPKLNRSGAIKHSTLVGEEINTREEEEKEEEEKEEEDPSVKILEAKAFTESHDEKTEEERGGTWEDIEESVLTAFLFDEEDRREMQQMKKRKGDSLEINEKFKKEKLEESKKYPEETDREKVQRKMKQILDILNTEGPIEDERIRMKKLIGEINSMQNRKISPNQTTQGEEKNIRCEQCKIKIEQERQRKETEKIIGIVNKGGDIDTFSQIHEKKWEDKVFEKTKWEHGGLQETIEKKECIIITKNEIKDGGVEGVIRTLREEVAEIIEECKVGDIEYIENAKKSSMANQRRQWYTYVTKVGEQGMYEMAVKAINIIKKREKPPETVRVIVNNEINKEDVRKALEFVGRKENIVWEIVIRGKEMDKGERHEQEEALLIKTGGKSYTDVLKEMNQKIDIGKIGLKVNRLKKQKGETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG73</accession>
    <name>A0ABM5KG73_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509192.1">
        <property type="nucleotide sequence ID" value="XM_050653235.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653235.1">
        <property type="protein sequence ID" value="XP_050509192.1"/>
        <property type="gene ID" value="LOC126886348"/>
    </dbReference>
    <dbReference type="GeneID" id="126886348"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="206"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="668" mass="77535" checksum="D53FABC833F420A3" modified="2025-10-08" version="1">MEIKQENCFSFSEIEFKTDVHEDKPDIVNIADFIKNEPVEDLSNEVTEGDDNINIRTNHINTELFIDDVKYELNNDYHLEDTKGVKLEQIEEGSSKDMDYEKETQRLLKLFEEVLTDEETYEDNDDQSEIDHVEERSECSDTEQEFEEDDQTEEDNVSFRREPHFMGKDKLTKWIKHCPPKNVRTRSTNIYERLPAIKQFVKTHSTPIDIWNSMFDEEMLNQVVICTNIKIETVTNDYTRQRDAKPTDIAEIKALIGLLYLAGIRKANHMNLEDLWRTDGTGIETFRLVMSKSRFQFLLQCLRFDNIHTRHERIQADKLAPIRTLLEKFNSNIKKCYSHTGYVTIDEKLEAFRGKCSFRQYIPSKPNKYGIKIFAISDAEEFYTSHLEVYVGKQPNGPFEVSTATQDVVERLCAHIYGSNRNVTVDNWFCSVPLADSLKSKKLTLVGTIRKNKKQLPLEFVQNNGRCIGSSMFGFYDGITLVSHIPKKNRNVLLISTMHYGDDIDPTTNKPEMIITYNETKSGVDVVDKLCAQYNCARSTRRWPRVPFFSVLNVAGINSFVVYTTLNEQSKTPRKEFLLQLSMSLTRDYQRVRAMSNNLPRTIRMRLREICGLPTEQVPVVTPGTSGRCAVCDWKKNRKTKFYCQICSKYLCLEHVTPLCISCFKNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPF8</accession>
    <name>A0ABM5KPF8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4774 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512080.1">
        <property type="nucleotide sequence ID" value="XM_050656123.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656123.1">
        <property type="protein sequence ID" value="XP_050512080.1"/>
        <property type="gene ID" value="LOC114326460"/>
    </dbReference>
    <dbReference type="GeneID" id="114326460"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031942">
        <property type="entry name" value="DUF4774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15999">
        <property type="entry name" value="DUF4774"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047356013" description="DUF4774 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4774" evidence="3">
        <location>
            <begin position="557"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4774" evidence="3">
        <location>
            <begin position="806"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4774" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131634" checksum="A2ABC88F02068894" modified="2025-10-08" version="1">MVFDRKWFIILICLLVEVCSRPQLNDNAAPPSVESKNVNTESKPDQLQKIAEKTTDILEKIAEVNKKHGLDNKTQKSVSPQKPTLGLPRSQNQHNVHFLSSKLEETARSEFRFPTSPFQNPILEFLEQEKVGNQNSNQYPSVYEITNRQSQDLTPAQGFQITSTDHNAQITPEDVIPGQSIKRKIVHQQTVLVPNPNYAMQTPMGYQYPFQYPVAPNPGAYKQNPEGTPVDTKYLNNLEKQTISNIRNIISNSQNQGYPAYYNTFLPIDNNPSQKQLYGYTFPNKPEQEQPSPLGQAPNTDNSYNIYIPYPTVETSRQNWNWPGANYFPVHIKDPFLQMYNAITTMIEYGPNAGSQNPCNKGRNPVTGKIKSDNIIREAKNSDEAKISVQVDGSRSSPQISINGDDRNGTYLDIEDIDIGATGDSSLKFTLNLRKEEREVKDDTDDIGTGRTSWDKIKVTGKSNSLVLNTNSSNARHSSKFPSDFHKDLRPITVVKNGPIRPTQAPIVSPPSRDPTNQTDEFGDESEEEKSEEIISNDNNKKLFSRDNTGSGVFIHRLKVRKGGVAIAGPGGIATAGSGGTAIVGPGGVAYTQPDSLAIAGSGTKVVAVDPTVNLGDLVKENGLPNKTRFDPVFPPSRIGKVVAVGPVIYYNKGKEFSIIPIGLRFPNWLPHPNIHQVGFYPFPPLPLQQQNIYPYAYRLIPDDSKTPKDSVITNKLTKNIKEVVPISDREDKKLANIHEISSKDELEENSLTPESKNSQLNIQKPPSLAPYRFHPLLNYIKNGNTIRPDKILRFRNTDSTNEDVTTLILKPVARSIAGVDGKAMATPVSKAILRKGTSVDILFEPDAIAIAGPGGIAHAESDLEISYEDECFRLSDKITLIPFYGGGKGQSLQIIEKSDGSVHTSIIKTPTKDEEDESTGIDNIIDTSELENPPLPSKFDLEDFGRNIKNIQSYAQKIISLQEILKQKGKLSPAQEAAYKENMDSLSSSALKLAEIQEKSNPIGLENREGISAWLENKKNSNNKNKNKKKEEDRKKDEEKKRKVDEEKRKEEQKRKQEKLEAEKEKEKEGEKEEGNQGEKEEGEKEEEGDGDTIGIGLPTDDASVAEARPVGLAVAGEGGVAASKPIATAVVGPGGLAIARPVGTAIAGVDPAQALIPIHAENYVLGSKPKGGHTETANEYLSKLITKFHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ28</accession>
    <name>A0ABM5KQ28_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512295.1">
        <property type="nucleotide sequence ID" value="XM_050656338.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656338.1">
        <property type="protein sequence ID" value="XP_050512295.1"/>
        <property type="gene ID" value="LOC126888244"/>
    </dbReference>
    <dbReference type="GeneID" id="126888244"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046654755" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="116" mass="12905" checksum="36A0DDBA07D05BD0" modified="2025-10-08" version="1">MSKTIITLIFVCCIVAHVQCKTFIECLDTDNKGVLTFDEQISSSSHGIISEQIPAGMFKSQITCIVIYFDNNITPVLTQGGVGARYVGLRLDFSSVLQSTYRVQIYTSEPEDYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ77</accession>
    <name>A0ABM5KQ77_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cecropin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512345.1">
        <property type="nucleotide sequence ID" value="XM_050656388.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656388.1">
        <property type="protein sequence ID" value="XP_050512345.1"/>
        <property type="gene ID" value="LOC126888277"/>
    </dbReference>
    <dbReference type="GeneID" id="126888277"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000875">
        <property type="entry name" value="CecC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020400">
        <property type="entry name" value="CecC/Srx/CECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38329">
        <property type="entry name" value="CECROPIN-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38329:SF1">
        <property type="entry name" value="CECROPIN-A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00272">
        <property type="entry name" value="Cecropin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4 8" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6 8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045902645" evidence="9">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="63" mass="6928" checksum="DAF2236E20E9F096" modified="2025-10-08" version="1">MKISFILIFAIILILTLTGEIEAKKFWKKVEKVGQNIRKAAKKTLPIIGGYVGIANQIKGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQC3</accession>
    <name>A0ABM5KQC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512393.1">
        <property type="nucleotide sequence ID" value="XM_050656436.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656436.1">
        <property type="protein sequence ID" value="XP_050512393.1"/>
        <property type="gene ID" value="LOC126888307"/>
    </dbReference>
    <dbReference type="GeneID" id="126888307"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="610" mass="71032" checksum="8092C32FEFAD51DE" modified="2025-10-08" version="1">MEFNIEIEEKFIDHDQRYIHPKPSTSTNFVDLKNEPEEDKSAMELQLKIKEEFVEVGHRYIENQLFTSLDHKELKNEQEADSSAMEVKVETKDEFAEDDQRCIETQPTTSLDLKDLNTEKCEDNLNLGFPQENTLEVMNVDSIDKKRSMSRPVEEKILNYEICAKQFAKVHTGEKLHKCKICFKQFSLADNLKKHLRVHTGEKPYKCKICFKNFSQQIHLKVHMRIHSGEKPYKCDICCKQFSQTSPLKTHMRSHTGEKPHKCDICFKQFRTSSNLKQHVNAHTGETPYTCEICLKQFSRNISLKSHLRIHSEKSPYKCEVCFKNFSQQSNLKVHMRVHSGEKPYTCDICFKQFSQTGPLKTHMSSHAGEKPHKCDICCKQFSQTSQLKSHMRSHTGEKPHKCEICLKQFINTSNLKQHLSVHTGETPFTCEICLKQFSHNSSLKTHLRIHTEEKAYECEICFKQFSSSSSLKQHLSVHTGVKRYKCEICFRKFSTAGNLRSHMKVHTREKPHKCEICFEQFIESSNLKTHLELHTEVKSYTCEFCFKQFTRADEWKKHLSMHSRQIPSSAMEFARAYHLKRPLRVYSGKKCSTVDQESPNGGPRSASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSE4</accession>
    <name>A0ABM5KSE4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513117.1">
        <property type="nucleotide sequence ID" value="XM_050657160.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657160.1">
        <property type="protein sequence ID" value="XP_050513117.1"/>
        <property type="gene ID" value="LOC114332392"/>
    </dbReference>
    <dbReference type="GeneID" id="114332392"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="109"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="510" mass="56151" checksum="BE1621B48A6D11A9" modified="2025-10-08" version="1">MAIDYVLVVDEESEYPIELPTEENGNLLLSTVTAQFPGASGLKYKVSVQSRTFRGVRLSDGVLHPPADEGWDNIVFCCVYPKENKRKHDDALEAPASKVKRLESKLNCTDLIVLGLPYKSTEKELKRYFEKYGELLVVQLKTDKEGRSKGYGFIRFAKYECQIKVLSQRHMIEGRWCDVKIPNSKEGSVPLPRRVYVGRLTEDITAEDVRQYFEKFGQVTDVYMPKDFRAFCFVTFLDPEIAQALCGEDHIIKGSSVYVSDAAPKNNSRKPNDTGEDNNNFGPSFKGNNFSNENDRFNGNDRDQNNFNNQGGNRGGPTDIKNFGPLMNPAFFAAALSQAASWGLMRNFAGGSNIASGRSNMMSSGGNMGGGGGNMGGGGRNMDSGGRNMGGGGRNMDNGNQEVKVQTNGINIHYNRPSDFNMMLNQPGRSNMMSSGGNMGGGGRNMDSGGRNMGGGGRNMDNGNQEVKETNGINIQTPNGSGRSMFNNSNDTSWGWQQNRDVIRREVSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT02</accession>
    <name>A0ABM5KT02_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050513318.1">
        <property type="nucleotide sequence ID" value="XM_050657361.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657361.1">
        <property type="protein sequence ID" value="XP_050513318.1"/>
        <property type="gene ID" value="LOC126889257"/>
    </dbReference>
    <dbReference type="GeneID" id="126889257"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="51"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="648" mass="72814" checksum="E52142A1DC728752" modified="2025-10-08" version="1">MSKNITLHLLLKYNKFRLIYSNKHKLLPIFHPTRRKYSQSTEVNFAEIPLDRIRNFSIIAHVDHGKSTLADRLLELTGTIKSGQNQILDKLQVERERGITVKAQTASLLYKYKGEDYLLNLIDTPGHVDFSNEVSRSLSACQGVILLVDANDGVQAQTVANFYLAFMNELVIIPVLNKIDLKNANPERVCQQLHSLFDIDAKDVLKISAKLGLGIDDVLQRIITKVPCPNVNRSSPLRALLFDCAYDRYRGALNLIYLQDGCISLGDSIATFYNKKEYEVKSLSVLRPDEVPVQKLVAGQIGLMGCNMRSTKEAHIGDTIHHSGAEIEPLKGFRPSRPMVFAGIYPMDQSQHINLRSAIDKLTLNDSAVSVELDTSPALGQGWRLGFLGLLHLEVFTQRLTQEYDAEPIITAPSVTYKIKLKPTKQNIKDGSDVIFINNPANFPDHLKIEETFEPMIIGTIITPDKYLGPVISLCMERRGIQRSANNIDNERVILQYELPLCEVVLDFHDTLKTISSGYASFDYEDNGYQSSNLVKLAILLNGTLVDELSNIVHVTKAKTIGRQMVLKLKDIIPRQLIHIAIQASVNGKVMARENIKPYRKDVTAKLYGGDITRRMKLLANQAAGKKKMRMVANISLPRETFIDVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXT0</accession>
    <name>A0ABM5KXT0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Contactin-3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514990.1">
        <property type="nucleotide sequence ID" value="XM_050659033.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659033.1">
        <property type="protein sequence ID" value="XP_050514990.1"/>
        <property type="gene ID" value="LOC114339594"/>
    </dbReference>
    <dbReference type="GeneID" id="114339594"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="90"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32544" checksum="FFA1E5E70C600CA1" modified="2025-10-08" version="1">MNIQGEIVREISVNIGKNITIPCLLHQTRDVMWVREGREDQQHARMSVLENGALFISQVDRNDTGVYACSRENVVNSDVTAKVKLTVRTPPPALANVVVRPSTILALLLWEVDGTGGYPIVNFTAQYRLGFTNNSWIPIPPNGIPQNSRQIDVYNLSPNTTYQFRIWATNQLGKGVITEVYGTTLCVYTEQELARYFLDNADKFDTTVWAIAVGIVMGTLVLLGLGTCFLLYQECKVPGVIEEQEIIELVPNIILNPGFDPNNVSDQLPDENSNSETPLRLNNNTVVQPNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZK9</accession>
    <name>A0ABM5KZK9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cilia- and flagella-associated protein 44</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515624.1">
        <property type="nucleotide sequence ID" value="XM_050659667.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659667.1">
        <property type="protein sequence ID" value="XP_050515624.1"/>
        <property type="gene ID" value="LOC114340030"/>
    </dbReference>
    <dbReference type="GeneID" id="114340030"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1776"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1223"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1839"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="2072"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2389" mass="278450" checksum="D7FB570A362601E5" modified="2025-10-08" version="1">MSESGNEGDISADEQENEMEISIPATQEAVSEKPDDQVELSKDSESPIASKLAEEGNAEGKKVKDVESINKNVEVEPKEAIEKGDTKALEIEHVKKESLKEDEIVEIEPKEAIEEENTKALEIEQVKEVSSKEDEIVDSDREVVLDEEVKDAGDKGQREEIKTEIEEHEKDVSQDQDENDEREMKVETEKEKEEKPEDQDIEPKEDIAETKADEKETMEIEEIPADQDIEHKEDIAETTIDEKEILEKEAKPEDQDIEPKEDIAETETEEKEILEKEEKPEDQDIEPKEDTAETTIDEKEILETEEKPEHQAETHEEAEAKDKQVEDKEEREDKSDMPTDETDVETTEEDDTEYEGVKKEDESEQVLEEVQKKTKYKARKSIKSLSSRRSKVSSTISEEEDEEEEDEFSEEAEEEEIEEEEEPEHYDADRLLSGPTICEGGTLPLDLLEFFHSFGYNCRKKFNLEVLDENTVVFASGNFLHFFNLETKEIWFRRSALGQGIGHIKRNPNKEYPHFAVAECGRRPIIILYNWPEMTILCILRGGAKKLYSNMDYSPDGELLVSQSGEPDYLITVWNWKEHKILLRNKSYVNDVYAVKFSPYIPGEITTCGVGHIKFWKMAHTFTGLKLQGELGRFGKTEYSDILGVLPMPDEKVVSGCDWGNILIWDGGLITLEVLRTLRKNCHEAPIVQIFYEDEELWTVSLDGHVRIWWYEKIDRADPPDDDRVILLDPSYDFYTPGMSLYQVTKRREEGSMFIAQDGNGGIWQIDLNTVTEPEPSMQLYKCHAGKVVDIATYCNGRYLASLGRDGRLYIYNYLTKKLIFGYEFPAKGSRMIWPEAELLPTGDVILAGFCDGQVRVCVVNLRNEENIILTITQVIKPHNKPLTAIQINSRASIVVTGAEDSTIFVFAVNTLQNMEEFLIPIGFIPAPDSVTCLTWHPKIDHTILVGCLHGQMMEVMVPTTPQSYTGVSYLLKVQPKYQNFMSYKSQIRRNIYLKKVAKRKAKKVEVKRQEMERIMKENPALEIDEEVFLADSESEEELEPLHIPEVRNRILWMRYTPDQTIWVSMAGYDAGYIYEYKMDQIDEVPYKFKMVHDADDTEISCYIIDEQQKYLILAMQDGSLRVNRINPKDFRDLKDYWSYSLHDNQYGFVSKLCFSHDHKFLFSCGEDGNVFAMIFHHEVYVPPLVIRPMIRISSVVFVEDVDPYTKLSLEETKIKAEEDRILKAANAHKANVRDILKVLKERYQKLLSRNNKLLPSQIIPRQQLELDDRVLQYINNEFQSKLDLVQRKLAYDLEKSEIQMKKLLKYFTDPCDMHPVQISGINDPSLYLLTVRQRIMSPMFATVLKICEEKIEEEKRKGRPPERVQVQAKIQVPKPSKQMALEYFLLSLTPSQIQNKLGPKLTRLLNKYRSRREKWDRRADEWEEFKARRPDPNKNHPDDEKFLQEAMNNVGYYKLKEADDYKPSPDERETTVKKYKQVLDTRLKQYNLRHSFIKSVYDVRDLKYEAIDKLKEYREYLKELHEELPVNLHQFGPNIPDLDPNEFPEEKLKPHVILEEKDESIESGYILEEYVPEPTIHQRERQLLPQRTTYPKINSDNIFIPTYNSNEIANVLEMDFDNLLTKYSDEVDTPMESELRAKRLTRKLFFQSTTIANMNRTIEEFNQVIEEGKKARLPVHPRGNFVDIYILTLNQELNILKQFEDGEDSLQNKVNKCLHQVHMMEDDIDVEKNKKLDIEHEIESNRLEEAKIQEKFKHVTETNKFYDFLKKVFRKRFRPPKQATDSDSDSESSSSSSEDTEEDDSASIDSRDFGFIKQDLNVCPKGCEQAIFDLTVELRGNRHTIEQNIKELQRVVDTINKNIEMSTRKLRIVETQYQQSINSLEAYQKEKQRLLNQVRCTVILNLDQIHDYNPEMDEISDYLVFSRSTLSSLYKRVGGLEFENLQQKMKYETYLEHITRMKKDLRYMRSRIKGLIQTIQQMMCEKFGKVVDINELELAMIKKTFNKTHINELEEVVLKKLVFDVRLKNTNIKDVYAAQIRKMTRRIQDCQEDLIRTIQGNTNRLELLQIMNREKKDLVKAIASQSKRRDKLESNVKASAQCDKDIKKLESIVEDQNKTIFNLKAEIKMLKTKGMPPKERYVEPKSTEEVELISESMKEWPEIEKYLESTREEPEERTLQEIDMPGFYLTETEDIITSLIHEILGTMKMKSKITLDAELVVTKILTHILNCVTVQQIINEIVSNIPCELTPKQKSLVESSAEKIFTIQKPDMSEESIIQYAKELLEDSVQEILQKKDEPYELVAELLENLVESMPKEFLFHEKSLNSLVDRLGSFISEHKLERDALTSKIERISSENRNEILAILDVILKEVYGTGIDYMYVIKKKSSHREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0K7</accession>
    <name>A0ABM5L0K7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515973.1">
        <property type="nucleotide sequence ID" value="XM_050660016.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660016.1">
        <property type="protein sequence ID" value="XP_050515973.1"/>
        <property type="gene ID" value="LOC126890877"/>
    </dbReference>
    <dbReference type="GeneID" id="126890877"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <begin position="97"/>
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        </location>
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            <begin position="34"/>
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            <begin position="45"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="7">
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            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515973.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="488" mass="57957" checksum="CBD3D24A981BCD1D" modified="2025-10-08" version="1">MEVKVEIKQEFDEYDQKYIDTRLSTSIDMEKYLKNEPGEELLGGEEQKEERDKEENKKPIIKTLTEHSSLEEKRMSQHHEDSPLNKTIKIQTRQELYQCEICSKLFSAEYFLKTHLRSHTGEKPYKCEICFKQFSQAFNLKKHLRVHTGEKPYKCEICFKQFSQAGHLKIHLRGHTGEKPYKCEICFKQFRHKISLDAHTTVHTGEASYKCEICFKQFNQKSYLKIHLRVHTGEKPYKCEICFKQFRDASRLKNHMLVHTEEKPYKCEICFKQVSRADNLKTHLMTHTGVKPHKCEICFKQFRDASKLKKHMQVHTGEKPYKCEICFKQFTHQHTLKIHLRIHTGEKPYKCEMCLKQFSQLTTMKLHLLTHTGGTPNKCEICFKQFTQQNSLKTHLRSHTGEKPYKCDICFKQFSQAFNLKKHLRVHTGEKPYKCEICLKQFSEAGHLKTHLRVHTGEKPYKCEICLKQFSQLTHMKNHMIVHTREKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1L1</accession>
    <name>A0ABM5L1L1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050660366.1"/>
    </dbReference>
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        <property type="gene ID" value="LOC126891183"/>
    </dbReference>
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    </dbReference>
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            <begin position="277"/>
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            <begin position="352"/>
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            <begin position="414"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="53445" checksum="C28A55DAD73F180F" modified="2025-10-08" version="1">MSETDSKLDLSSLVAELNSILEPNSNKDNEMAQTNYQLLKLYLDSIPAYDGYPHTLTIFIENCENLITNFASQTDGTLNTFLLRAILGKLNGRAQMLIGSRTELNTWQLVKDALNLSFGDQRDLDCLIQDLITLRPFKNETPYNFGMRCQETRSLVAQKLNTLNIKAPEKLIRIQSYDDLCLKTYIRGLPLSLQTNIRLRNPDSLEKAMCFVIEEENFLYSLQRGNNLNSQNSFRPSSRHTPMRNNNINQTFIPRNNFQQNRPNMRFPPYQYQNIRPQYQNNNFNPNNTFQPNQNHFRNFSNYNSNFNPRNFDNNNSNFRPRYFHNNNSNYQQRNVNNQPQNQNQYQPEPMDTNSRNTSLRSKPHFTSTQLFNQQINNDKIQFENPFENNNIPTDYEYPTQSSLPYSLPPYENNYETQSSPYQTQDNTNERSYHSPTQNVENVNFCMTQENYNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1S7</accession>
    <name>A0ABM5L1S7_DIAVI</name>
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        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_050660433.1"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="PROTEIN CBG23764"/>
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    </dbReference>
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        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1250" mass="145419" checksum="0743D9E5396CE739" modified="2025-10-08" version="1">MNTCSRCDKSYSRSDNLSRHIKKCKYGNVDSDKNGDYYIPKKRLRPLGVEVIDGTVSKLSHAFKNRIASYRFSSDKKLDYHGFLNDVKPKVLNILSEYLHQHNSIKVNFEIFGIYLKPDTNLSDIKSMNTCNKIITISTELDEVFDDFKEELMTQASEFQEKDSNWVLQEIMFLDVNINKFSSISASTYIRLPIPIVRKHAILNIENKDNKCFAWSIIAAIFPASGNPTKPESYPPYDTLLNFEGIDFPMKLKDIKKFENLNNISVNVYGLESNFVNNKRQYEIFGPLHFTSNRHATHVNLLLITNDKQSHYCLILDMSRLVRSQKTKDRHKVYLCDGCLQFFVCEEKLDNHQNNDCSHIYTELPTTKPKINKFGEMVPENILKFINIQKMLPVPFVIYADFESLLKPIDHVEPFNGNSYSVKTAEHQAYSFAFYLKCNYDDSLYKLIKYEGQDAPKVFIQKLDDLVHELYNNHLKHIKPMSPLTKEEIEKHETATECYLCGKPFNPFNRKVKDHHHLNSLYLGPSHNSCNINNKLSNTIPVFFHNMSNYDCHLFIKELSTTGEKVSVIAQTKEKYITISKRILVEESKNGLDKYITLKFVDSYRFLAKSLDILSTTLNSEQCTEIRKYFPNTKHFELVRHKGVFPYSYMDGFDRLKEKTLPPKENFYNNLTNKHISDEDYARAIDVWNTFDCKSMSDYAMVYLVSDVLLLADVFENFRKICHKEYNLDPCHYITAPALSWDAMLRYTEIELELLTDVDMVHFLKKGVRGGVAQCSKREAVANNQYVPNYDPQQPKSYIMYLDATNLYGAAMCQYLPYGNFKWVTDVENFNCFVVEDDADKGYVLEVDLEYPAHLHYLHNDLPFCPESMVPPGSKCPKLIPNFNNKTKYIIHYRNLKQCLRYGLVLKRIHRILEFLQSPWLKKYIDLNTSLRNKAKNEFERDLFKLLVNAIFGKTLENVEKRRDIRLCTRWETKTNSLEARVLISKPEFKSCSVFNENLAAIHLGKTKIVYDKPLYVGFTILDLSKTVIYDFYYGYIKKKYGEAANLLYTDTDSLIMEIYTPNFYEDMKINLEHFDTSNYPTDNIHRIPKTPSILGKMKDEFASVPIKCFYGTGAKAYCIEANKIIKKAKGISKHVTKTQLQKSDYVLLVKKGGVIFRKMYVFVSNLHTIYTELRNKVALSSKDDKRCVINGDVKTLAWGHFLISPHNGTIDDLIRYGNELLHTPELVDLEKIPLEELFQVDSFQYDSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1V0</accession>
    <name>A0ABM5L1V0_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">Mucin-2-like</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516416.1">
        <property type="nucleotide sequence ID" value="XM_050660459.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050516416.1"/>
        <property type="gene ID" value="LOC126891281"/>
    </dbReference>
    <dbReference type="GeneID" id="126891281"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="1"/>
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            <begin position="10"/>
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        </location>
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        </location>
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            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="319"/>
        </location>
    </feature>
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            <end position="335"/>
        </location>
    </feature>
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            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
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            <begin position="425"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
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        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="145788" checksum="E2D85BFB35278835" modified="2025-10-08" version="1">MQLAPRTKHYASSTTHQAPRSEHQAQSTAHHLQRTKHHAPASSTTYQAPRITHQAPRTKYHATCTTHQAPRTTHHATSITQQASRNKHHAPNTTHHAPRTMHLQPSHTHQAPRPKHHAPSPKHHAPRAKHYAPCTRNHATYSTHQSPRTKHHIQSTRHHEPSTTHQAPRTKNHAPSTTHQALRSKPHAQTPRTKHQHHALNTTHQAPRTTHHEPSTTHQATHTKPHAHAPRTRHHAKSTTHQAPALRTQHRAPRTTPQEPSTAHQAPPTKQHAPSTQQSTTPNAPSTRTTHYTPRTKHYAPSTTNQAPPPSTKQHSQAQRTKHPSHSTTNHAPNTTHHEQTPRTKPQAPPTKQHPPITTHQAPRTTHQATSTTHQAPRTSHHASSTTHKAPSTTHQAPRTTHQATSTTHQAPQTSHHASSTTHKAPSTTHTAPSTTHQVLLPKHHAPNTAHQAPRTTNHAQRTKNLAPRTKHHQPSNTHPAKHYAPHYTPRTKHYAPRTKHHAPRTRHHTLSTTHKKPCLSTTHQVTRTKHHAPTTLTSTTHQAPLTQHHSPRTNTSHQATSTTHHPLSNTHQSPRTTHQETRTTPQHPAPSTTHQAPRTKHHEPRTTHQAPRIRHQAPRTKYYTPSTAHNAKSTKHHAQSTAHHAQRSTHQAPRPKHHASRTKHYAPTTTHQAPRTKHNAPRTKHHTPCTTHKKPLFKHHTPSNTHQAPRPKQHSQAPRTNHPHHAPRTNTSHQATSTTHQALRSKHHAPSISQQAPLTKHHAPSNTHQAPRTKHHGPPTKQHAPAPSTTHQAPRTKLHAPCYTHHAHHTPSNTHHAPSNTPTTQVPSTPHPAPRTTKNAPNTKHHEESTSQQAPPTKQHAPSTTPKHRAPSTAHQAPRTTNYAPSTTHQAPRTKHHALSTKHHVQSTRHHEPSTTHQAPRTKNHALSTTHQATRTTHQATLTSTKHTSPSTTHHEKHTKHQAPRTKHLAPSNKHHAPPTKQHAPSTTHQALLSKHHQPSTTPQATRTNHHAPITTYKAPRTTHQHHALSTRAPGTAHEAQSTTHNELRTKHHEPSTTRNAPRTEHHAPSNKHHAPPTKQHAPRPYHQAQRTKHRTPLTTHQAPRIKHHAQSTGHQEPRTTHQAQRTTYQAPRTKHHAPSTTNKATRTKHHAPSSTPRTPRTKNHATSTTQQAPRTKHHPPSNTHQSPRTTPLAPSTTHQAPRTKHRTPLTTHQTPRTRAPRTTHHAPSTMHIAPRTLHHALAPRISPLAPSTKRHAPRTKQPAARTTHIAPRTSHIASRTSHLAPRTSHLSFSHTLVYVVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2F0</accession>
    <name>A0ABM5L2F0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516613.1">
        <property type="nucleotide sequence ID" value="XM_050660656.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660656.1">
        <property type="protein sequence ID" value="XP_050516613.1"/>
        <property type="gene ID" value="LOC126891478"/>
    </dbReference>
    <dbReference type="GeneID" id="126891478"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="70073" checksum="06E71BB5250ECBCE" modified="2025-10-08" version="1">MKVLLRNFRHLLQITTKEKLLLDAIRRQGNFVSSLSTNNIRPVRRPKEAEDVDTSLFVSCPDCMGFFRRTYLRRHRKQCSARSKCKTVKRENHLSLSQVFTVCSGVHGDFLASLRLKKEVFPIMRSDEISRTAMKDMLICSYAESLLRKHKRAQIRNVISNKMRELGRLLISLRNTTGIQLLFDALKPQFFDNIVGAVKVISGYCEETKTFQASSLALHMGTTLKQVCDIATKNIIQKSPIIICTTAEESLKDIKRLKNLIENHWTSEISSLALKNLKENNYVSPKLLPLTQDVIKFQTFVMNEAHEASDALKKNIHIKLNYRKLIESVLALTLLINRKRIGEIQYLKTETYNSTVSENQQTEFLDCLSKTEQTLCKNYKRVVTGGKGSRPVAILFPPDLQKFIELLLSFRSICVTPTNPYLFGNPNTELWLSGYHIVKKLATKADVSDTTLFTSTRLRKQIATLLQAINIKDDEMEQFATFMGHTKKTHESYYRLPQDLYQTAKVAKLLIAVNSGQVAKYKGKSLDEITLSDNESLLDETEAEKPLFHDQNINENEIEETWEQQFGEHAMKNAVLESIFVIFESNSGNAERIVSATLKSFTLNWPGSSNVTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L336</accession>
    <name>A0ABM5L336_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516840.1">
        <property type="nucleotide sequence ID" value="XM_050660883.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660883.1">
        <property type="protein sequence ID" value="XP_050516840.1"/>
        <property type="gene ID" value="LOC126891657"/>
    </dbReference>
    <dbReference type="GeneID" id="126891657"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1659"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1675"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1836" mass="210963" checksum="3C9CDF4084157E8C" modified="2025-10-08" version="1">MSNISWASNIWKLLRVDINEDKWKRPISSSELNKKNKESITKQLFIVVTRSEETDAEDSIKHKHKHRSRVHKIIRRLERKYPDKPIRGSYVDVSDITLNKNFKFVNNTVILKSQGRQKYICYVCTKRFNNAFDMYKHRDTHDELDDFKIPTKIESPTHKRIKKIFKQFSNQEANIPDGGLGKNNKTQNVTQDGKTKDTRKVESLKIHLKTQEVDKIQTTESIENSKPPNDIDDNKTEDNRKVEALKINLSTREVDKIENIVPAEDNKPPNDTDDNKTEDNRKVKALKISLSTQEVDKIKNLVPVEDKEPPNDTEDSITEDNRKVEALKINLSTQEVDKIKNIVPVEDEKPPNDTEDSKTEDNRKVEALKSNLSTQEVDKIENIVPAEDNKPPNDTDDNKTEDNRKVEALKINLSTQEVDKIKNIVPVQDEKPPNDIDDSKTEDDREVEALKINLSTQEVDKIKNIVPVEDMKPPNDTEDSKTEDNRKVEALEINLSTQEVDKIKNLVPVEDTAPPNDTEDSETEDNRKVEPMKINLRTPEVDKIKNIVSKENSKSPTDTEDSKTEDTRKIEALKINLSTQGVDKIEHIVPVEDKNPPNNIEDSITEDTRKIEALKINLRTPEVDKIKNIVLKENSKSPTDTEDSKTEDTRKIEALKINLSTQGVDKIEHIVPVEDKNPPNNIEDSKTEDTRKIEALKINLRTPEVDKTKNIVSKENSKSPTDTEDNKTEDARKVEALKINLKTPEADKIKNIVSNENRKSPTDTEGSKTEDARKVEALKINLRTSEVDKTINIVPKEKSKSPNYPKDSKTEDIRKGKVVKKIYRKRKRLVVNVIRDKTTEKLLENMESRTDIEDKNEASEVERNLRDIFRELVSEINSGTYNTELETSFVKRVKRMGSDNFCSSSNLDDIGDLKECFFKEQKYKGEVATANKNDSETSQNSIQKMKESQPINVCHTSTLDKSDLKKSSLKRSECKSKGTTAHKTDSGTSKNGIEKRKENQPSNFYHTSTLEESDLKKSSFKRSERKNKGTIAHKTDSGTSKNGIEKSKESQPSNFYHTSILEESDLKKRSLKRSERKNKGTTAHKADSGTQKNGIEKRTESQPKNSYHTSTSEESGLKKSSFKRSRRENNRTTLYKINSQTPKICIEKVKESNSDNFEESSITNVRQKTKKTESIYVNRESNRRYSRYSYDDWLAFESKNMANTESMNVNEDQWLAFESKNMVNTEAVDVTEDQSNNDYSNDNEALTEIVLEKGGIEKPETIEDAVEESNNDCALSSEDCSESAFDNEDIFGNGDILENEDILENLDILENIDMLENGDILEILVPDIGQEEIVQIDNDTEEELETDDKEPEEPGDIRSFNGPIEVVDRNEYLKLNEGDIKSVETVLVLTNNDGQVVDMSYLQPYESEKDNTKDICKKTSSVQRNINNNQEKERKTSSVKKKGRPKEFVSSKHNFKCQSCGIYFENFKNFVYHSFVSRTDCLYYCKRCDREFSNAKDLCRDICRHSYSYNFFSCCFCSPTKSKHFNSFGEIRSHLIKHHKYDKSNMGSVALLKMYYSNRPFKCQIHVCKKCSYIFETLHSLRLHKIDCVKPNSSSKDKKKKEDSRDKATPSSSLGTIGNVDLENSIDLSQNKIVVMLDNVPMIAKLDYRPETLKTADTTTGLIEQNKQKKRDNTCKQNAADTTTGPIERKKHKRRDTNTGTTEPNNRNKHKRKETTTSPLELNKHKRRDTTICTTEPNKHKRRDTIRGTTEPNKHKRRDTTTSTTEENKHKRRDTTTSTSEENKHKRRDSTTGTIEPNKPKRRNTITDILEPNKHKMRDKKFKENVQKHKKVSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L343</accession>
    <name>A0ABM5L343_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516866.1">
        <property type="nucleotide sequence ID" value="XM_050660909.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660909.1">
        <property type="protein sequence ID" value="XP_050516866.1"/>
        <property type="gene ID" value="LOC114325027"/>
    </dbReference>
    <dbReference type="GeneID" id="114325027"/>
    <dbReference type="Proteomes" id="UP001652700">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="282"/>
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        <location>
            <begin position="310"/>
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        <location>
            <begin position="338"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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            <begin position="102"/>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
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            <dbReference type="PROSITE" id="PS50157"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516866.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="432" mass="50026" checksum="FE7B1250C00F97B3" modified="2025-10-08" version="1">MVDSDNDYTSEDSKKRSLEIDADNIFNKSKKLSRTPTKQQKDENKIDQLLKMMQNLTDQTQSLTSEVKGIKEEQREYRNDLRELRKEINEFKQIPWTHILRAKSNSKTSKSRREKPKKPTEVEPNILDEPLSCNNCFKIFFNNVAFALHSIEHSEDLLFSCHLCSVKLKSAYRIEKHVRSHEGSKRYKCEVCGKAFKIGTHALEHVYFHNGEKPFPCDICGKRFMYSRLLSSHRRLSHYTVLTGKPLVKFDCKICGKHYESNQGLQQHLYSKHNDKGIDKSVICEFCGKKIKNKNKLKFHLSIHTGDKPFSCLVCHKKFAKKDFLQAHMPVHTGEKPFSCQQCGKSFAHRAPLWYHRKTHTGEKPNVCKICGKGFISKPAMDILIARKMVGLKKSQFVTQLVMESLGSQYFLLGHVVPPMRDLIMNGRYKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L360</accession>
    <name>A0ABM5L360_DIAVI</name>
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        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516865.1">
        <property type="nucleotide sequence ID" value="XM_050660908.1"/>
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        <property type="gene ID" value="LOC126891671"/>
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    <dbReference type="GeneID" id="126891671"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
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            <begin position="128"/>
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        </location>
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            <end position="302"/>
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            <begin position="31"/>
            <end position="51"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516865.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="337" mass="38802" checksum="8D3F9C2D472D53D5" modified="2025-10-08" version="1">MLKPKKQKRGRPKKVKVVVKPDITALPAKVKKEEDDPDFIDESEIKPPTKKRGRRVDTEIVLEKFINLNEVTKPLICKFCSKAFLTHVEFGIHSREHNSDGTFSCHLCDYKKDNKKSFKIHIKSHDLYKCEKCSKILKSRLCAYKHSRSHIVENTVQCEICGKNLKKQCLSIHKKILHSEDRANLITRCPICDKEYQNPSSLRQHYSAFHKELGIDVSVVCDICGMRLSCKGKLPQHVRTHTGDKPFACHLCPKKFIAKDILAAHMRVHTGEKPYECQFCGKRFAHSAPYRYHVKTHTGEKKHLCPLCNKGFISKANMKIHLKSCNMPYTTIIKSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABM5L4N8_DIAVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517395.1">
        <property type="nucleotide sequence ID" value="XM_050661438.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661438.1">
        <property type="protein sequence ID" value="XP_050517395.1"/>
        <property type="gene ID" value="LOC126892019"/>
    </dbReference>
    <dbReference type="GeneID" id="126892019"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="175" mass="19530" checksum="D53147BCB22686DE" modified="2025-10-08" version="1">MAETTSDLNTDTEAGNKRHRKKKIISSSSESDENDEPTEHASNRKQFKVTKMPTPPIWTNDMAEMVDELTVSNTPSQTGNSSTPCFTPGQVHHDRNMGPGSKSNYTTPKRALKEIHENLNNVVVTSQSTSCCCNPQLLYNIQSLLIEINSKSKIVVSEICKLMKSLQIIYCKNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L630</accession>
    <name>A0ABM5L630_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517894.1">
        <property type="nucleotide sequence ID" value="XM_050661937.1"/>
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        <property type="protein sequence ID" value="XP_050517894.1"/>
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    <dbReference type="GeneID" id="126892409"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045824535" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="122" mass="14548" checksum="81783C0602DC7BD9" modified="2025-10-08" version="1">MCKYFLLIFAVCVVAAAVAKTDEEDKLFDPYRLPKNEKEIQEFLFDHYKEIFTKYDESPEQKLQKIASFRANFNLLLDCHFKYKENVEAKKSCNIKYKLPDSLTEDDALNIFFVKRQNTEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7C4</accession>
    <name>A0ABM5L7C4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518339.1">
        <property type="nucleotide sequence ID" value="XM_050662382.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662382.1">
        <property type="protein sequence ID" value="XP_050518339.1"/>
        <property type="gene ID" value="LOC114327645"/>
    </dbReference>
    <dbReference type="GeneID" id="114327645"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="89" mass="9832" checksum="913338C0AA02D6C5" modified="2025-10-08" version="1">MSLDERFQKAAADIKNLKSKPTDNDLLEIYGLFKQATEGDCTTARPGLLDLKGKAKWDSWNGRKGSSQDKAKEEYIAKVQSLIDSLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7J3</accession>
    <name>A0ABM5L7J3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518405.1">
        <property type="nucleotide sequence ID" value="XM_050662448.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662448.1">
        <property type="protein sequence ID" value="XP_050518405.1"/>
        <property type="gene ID" value="LOC126892763"/>
    </dbReference>
    <dbReference type="GeneID" id="126892763"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="101574" checksum="CD4AD56E3E56DF75" modified="2025-10-08" version="1">MALSTLYDRLETQLRALGTLGVTSDKYVAMLLPLVESALPYELLKIWERNRASNNLKFNNELQGLLEFLKTEVEAEERVKLAQSSFTVPKSIDDKYTVETLHTKSLKTKGKQKFSCIFCESNTHASQDCIKAQKMTLEQKKSIISKKRSCFPCLKQFHNFRTCKSTVKCIKCARKHFTLMCPHLHEKENKNRDLQKSESLENTLTTVASETLLQTINVRVISDNKRSMTVRALLDSGSQRSYITTKCAEDLGLTKIGQENIVQGVFGGLQGAPKIHRLFKAGIENLENSFSIGLSLLEQSKICNYVPKLIDQKVLDLLKDKNIYINDSASKELEVNLLIGADMFGHIITGNLVNINDSLVALETKFGWTVMGTQKSNNKINTFVSTYFTDSLSTLWSLDVLGIKDPAETKCREELDIRTLEKFKESTVVNSENRYEVCLPWAEGYPAITSNFNLAEKRLFSTTKRLVSLNKLTEYDNIFQDWENTGIIEEVEEEPLEKNMHYLAHHAVVKESSLTTKIRPVFDASAKDGNGNSLNDLLEKGPNLIELIIPLILKFRLHKIGVTSDIAKAFLQISISEKDRDFLRFLWWKNYEKREIKIFRHCRVVFGLKPSQFLLAATVNLHLEKEKTYTETANQLLNAFYVDNCVFSVRNETELKKFIDESTEILKNAKFVLRGWTFNENNDTYVSSVNEKLENKVISILGIQWNYQTDTLACDIKNLDSLDEIPRTKRGILSATQRVFDPIGFTAPFTLIPKILLQETWSLKLTWDQKLPDDIKKRFEIWLKSVKCLNFCNVHRYLAYPEEENLIINKTLHVFVDASKYSYAACVFIRLEFQNSISIKLLLAKSRLSPIKTITLPRLELMAAVIGVRLLETVKEVADFAELKTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8N4</accession>
    <name>A0ABM5L8N4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518801.1">
        <property type="nucleotide sequence ID" value="XM_050662844.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662844.1">
        <property type="protein sequence ID" value="XP_050518801.1"/>
        <property type="gene ID" value="LOC126892929"/>
    </dbReference>
    <dbReference type="GeneID" id="126892929"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="164" mass="19119" checksum="D660B9C84569701E" modified="2025-10-08" version="1">MFPSISANIEEMKSVIIEHLTLLEEKIDHYFPSLNTDNYDWIRNLFISINMSKYQLSLQEEEELVGLSTDRNLKLKFSEMSLEEFWISVQAEHPLLSTRAVKVLLQFATSYLCELGFSTFTNIKTKKRERLGNIDEEVRVALSHIRPHIAKICKSHQHQAQVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8R5</accession>
    <name>A0ABM5L8R5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KICSTOR complex protein ITFG2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518832.1">
        <property type="nucleotide sequence ID" value="XM_050662875.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662875.1">
        <property type="protein sequence ID" value="XP_050518832.1"/>
        <property type="gene ID" value="LOC114326984"/>
    </dbReference>
    <dbReference type="GeneID" id="114326984"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031793">
        <property type="entry name" value="KICSTOR_ITFG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317">
        <property type="entry name" value="INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16317:SF1">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN ITFG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15907">
        <property type="entry name" value="Itfg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56113" checksum="6649B9399FCB7E81" modified="2025-10-08" version="1">MRAISLVNRFEFEFPGNVARNAIILGDVDNDGCNELIVGNQNGEVAIFKGRERHQSIPKLNFIGCMAVGDITNQNKNVLIVITADGWCYLYINPVPLVEDSFQKEKDEGVEEVDGQSHSVTGNIEVTPPADVPSTSKVKTEKKEKIQLVCFHVQRIPANTKDIIIGDIDGDGNFEMVLGLTDRVVRSYKWMSNPNRSTLDISDVSNQFEPSDKILGKFVALNKWECANQIGSITLHHSADGKPSILIAQPGGTFMRIKCQSDDLIGEECIESSVHSNSGSSLGENITSSIDYQFLGISRMRNQNISTEILGDLRYSQYDSGVSIDKSSCSSQKEPSSAPTKGKPYALATLDGTIMLVQDEVILWAIAVDHQIFALTKLDVTGTGSDDIVACSWDGETYILDQDKNSVRFHLDEPVQAFQSGYYNIQPDVPDVTCLVYVTFKNSIIVYYDLPLKELICKKFEPDVVKLSELFIGDGREPEEALEYVKNMDRKTRRDLVEYLMYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8U9</accession>
    <name>A0ABM5L8U9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518864.1">
        <property type="nucleotide sequence ID" value="XM_050662907.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662907.1">
        <property type="protein sequence ID" value="XP_050518864.1"/>
        <property type="gene ID" value="LOC126892962"/>
    </dbReference>
    <dbReference type="GeneID" id="126892962"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719:SF1">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046374666" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="134" mass="15571" checksum="1F855B5838027861" modified="2025-10-08" version="1">MSLGCKVIVVAFVVFFFCGGKDFKELNELYLEHRENSSSVPCGEPQQRAVYLEEILNKELWNKYKKWISKMKPLHTILHRCEGSGGCNKHYGYRCKENETDPVNLVYYLGYRDDLVKFTVLNHTSCICGKYNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9V0</accession>
    <name>A0ABM5L9V0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519219.1">
        <property type="nucleotide sequence ID" value="XM_050663262.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663262.1">
        <property type="protein sequence ID" value="XP_050519219.1"/>
        <property type="gene ID" value="LOC114345371"/>
    </dbReference>
    <dbReference type="GeneID" id="114345371"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="78"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="365" mass="42306" checksum="63A4F650EE191032" modified="2025-10-08" version="1">MAHKTEKFSLRPLEESRLYLEDRLSHFKRSDTHAIVPYKKSGRIHLSPPSIPKYVIPTEEIEQVHRALAAYKCKEYIMQHINQFQTIFVQGEPASGKSTQIPQFITEEAALRRIPCKIIVIQPNKIAAQVTAERVAFERNEPVGISIGYHVVLEQLYGIHTNVIYCTPSVFLRKLCGNLNDLKNITHIIMDDIQEYDYFSDFIVIALQKYLRGWNIKLIILSADYNCHRFVKNFERSGVCNLQHIPLPINILYLEDLSPTFNHQPVTDNVDRVNYDLIVSLLEYKEGTILVFLPTCEEIEICKDRIVNSLDPSTYTLFTIHSSMDAKECKEMYKFHNRKIILCAEMNVYNHRVNCVIDTGRDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAG8</accession>
    <name>A0ABM5LAG8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050519435.1">
        <property type="nucleotide sequence ID" value="XM_050663478.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663478.1">
        <property type="protein sequence ID" value="XP_050519435.1"/>
        <property type="gene ID" value="LOC114343473"/>
    </dbReference>
    <dbReference type="GeneID" id="114343473"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06615">
        <property type="entry name" value="PKc_MEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="101"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="404" mass="45064" checksum="6B6740ECC201D6F1" modified="2025-10-08" version="1">MASFKNMKPDGDTISSSDSSDEDLFFDSETLQAESPIFFNSDSGRPDNASNLVRGNSIENLTARIEELDSTLEMDDTQRKRIEVFLCQKEKIGGEFSDDDFEKLGELGSGNGGVVTKVRHKGSGLIMARKLIHLEVKPAIKKQIIRELRVLHKCNFAHIVGFYGAFYSDGEISICMEYMDAGSLDLILKRAGRIPENILGKITFAVLKGLSYLRDKHAIMHRDVKPSNILINSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPDAKTLASIFGPHNDSDSPDHTKGPRPMAIFELLDYIVNEPPPKLPSGIFTDDFKDFVDRCLRKNPDERADLKTLMNHAWIRKTESEDVDIAGWVCKTMEIHPPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-09-16" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0G3BE93</accession>
    <name>A0A0G3BE93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein hunchback</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hb</name>
        <name evidence="19" type="synonym">LOC114324933</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="Insect Biochem. Mol. Biol." volume="63" first="54" last="62">
            <title>Parental RNA interference of genes involved in embryonic development of the western corn rootworm, Diabrotica virgifera virgifera LeConte.</title>
            <authorList>
                <person name="Khajuria C."/>
                <person name="Velez A.M."/>
                <person name="Rangasamy M."/>
                <person name="Wang H."/>
                <person name="Fishilevich E."/>
                <person name="Frey M.L."/>
                <person name="Carneiro N.P."/>
                <person name="Gandra P."/>
                <person name="Narva K.E."/>
                <person name="Siegfried B.D."/>
            </authorList>
            <dbReference type="PubMed" id="26005118"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Gap class segmentation protein that controls development of head structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KR152261">
        <property type="protein sequence ID" value="AKJ26288.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128654.1">
        <property type="nucleotide sequence ID" value="XM_028272853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0G3BE93"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272853.2">
        <property type="protein sequence ID" value="XP_028128654.1"/>
        <property type="gene ID" value="LOC114324933"/>
    </dbReference>
    <dbReference type="KEGG" id="dvv:114324933"/>
    <dbReference type="OrthoDB" id="10015593at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001301">
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="PROTEIN HUNCHBACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
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        <property type="match status" value="6"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0302">Gap protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="188"/>
            <end position="211"/>
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            <begin position="425"/>
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            <begin position="498"/>
            <end position="517"/>
        </location>
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            <begin position="46"/>
            <end position="57"/>
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        <location>
            <begin position="364"/>
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            <end position="469"/>
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        <location>
            <begin position="505"/>
            <end position="514"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00003983"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
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            <dbReference type="ARBA" id="ARBA00013638"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022492"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AKJ26288.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028128654.1"/>
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    <sequence length="573" mass="64055" checksum="CA5DE758D664B0A7" modified="2015-09-16" version="1">MRGGVSDDMTSTCVQGGIRPIGRYQPNMLMEPSSPQSAWQFHPAMPKREPVDHDGRNDSGLASGGEFISSSPGSDNSEHFSASYSSPTSCHTVISTNTYYPTNLRRPSQAQTSIPTHMMYTGDHNPLTPPNSEPMISPKSVLSRNNEGEHQTTLTPCASPEDASVDATDSVNCDGALKKLQATFEKNAFSEGSGDDDTKSDGEAEEYDEQGLRVPKVNSHGKIKTFKCKQCDFVAITKLVFWEHTKLHIKADKLLKCPKCPFVTEYKHHLEYHLRNHYGSKPFKCNQCSYSCVNKSMLNSHLKSHSNIYQYRCSDCSYATKYCHSLKLHLRKYSHKPAMVLNPDGTPNPLPIIDVYGTRRGPKMKSEQKSSEEMSPKPEQVLPFPFNQFLPQMQLPFPGFPLFGGFPGGIPNPLLLQNLEKLARERRESMNSSERFSPAQSEQMDTDAGVLDLSKPDDSSQTNRRKDSAYKLSTGDNSSDEEDDEATTTMFGNVEVVENKELEDTSSGKQTPTSAKKDDYSCQYCQINFGDPVLYTMHMGYHGYKNPFICNMCGEECNDKVSFFLHIARNPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYU8</accession>
    <name>A0A6P7EYU8_DIAVI</name>
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        <submittedName>
            <fullName evidence="5">Proteoglycan 4-like</fullName>
        </submittedName>
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        <name evidence="5" type="primary">LOC114324511</name>
    </gene>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
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            <taxon>Diabroticina</taxon>
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            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="23"/>
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    </feature>
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            <begin position="244"/>
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        <location>
            <begin position="50"/>
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    </feature>
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            <begin position="68"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028128171.1"/>
        </source>
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    <sequence length="368" mass="40409" checksum="27696E239C3DCD75" modified="2020-12-02" version="1">MEHRMLFFWICTIYLIVSPTLADEDANKKVCRIVCKNPGGGTATTKSPLASSTTQNSNSETTTASPGEPTTPQTDNSSPLVETTTPENSSPTVEPTTPENTSAAETTVAETSPVTSAGSSPTTTEETNNESTTQGVENSPTTEEVHESTSTETVTDSTTGAPEGPTTTPEGPKITESNDSPTPGDVTSPTQPDTTEEVTATTEQVTTPGQLSACPCSCIENGKVYTGGPKAASRLHKNKYTAESNRHHGDHHGHYKSLHHASHNHHAEVKHHDSHHLKHAEGKHHERHHHAEGKHHDSHHQKHAEVKHHDSHHKHAEVKHHEGHKIHHQEKAHHQQHAHEKHHEAHGHHQQHYLKEKEHHSHQERLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0C1</accession>
    <name>A0A6P7F0C1_DIAVI</name>
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        <submittedName>
            <fullName evidence="9">Formin-like protein</fullName>
        </submittedName>
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        <name evidence="9" type="primary">LOC114324638</name>
    </gene>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128307.1">
        <property type="nucleotide sequence ID" value="XM_028272506.1"/>
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        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272506.2">
        <property type="protein sequence ID" value="XP_028128307.1"/>
        <property type="gene ID" value="LOC114324638"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell migration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell shape"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="FMNL_animal"/>
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    </dbReference>
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        <property type="entry name" value="GTPase-bd"/>
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    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06371">
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
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    </dbReference>
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        <property type="entry name" value="Drf_GBD"/>
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    </dbReference>
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        <property type="entry name" value="FH2"/>
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    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="41"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="578"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="864"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028128307.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121606" checksum="996BAA369F0AF352" modified="2020-12-02" version="1">MGLTMSKQETSAPEADSVISSKLHGRQASIRQSAIKAKAKQPMPDPAELERRFTKVLASMDLPPDKAKLLKSYDYEKKWDIICDQEMVQAKDPPSYYLNKLRTYLDPKASRSHRKRKMVVDSTSTQVLRDLEISLRTNHIEWVREFLNEENLGLDVLIDYLSFRLGMMRHEQRIAESRTGSEEKLSTGGQNTLNNTQTTLEKNNGYIRAPLDIQESPNVKRRSKHVAKLNMGDSKDDIHVCIMCMRAIMNNKYGFNMVIQHREAINCISLSLIHKSLRTKALVLELLAAICLVKGGHEIILSAFDNFKEVCHERYRFQTLMDYFLNFEAFHIEFMVACMQFVNIIVHSVEDMNFRVHLQYEFTALGLDNYLEKLRFTESEELQVQISAFLDNVFDVAALMEDSETKTAALEKVGELEDEVAQLHERLQDIEHRALENIASLETELIQVRQERDELVEVKKKADEEVSTLRRVVQHHEQESKNRQSMFESKMAELETMGSIPRGTSMPGIADLAKQQSQEPAKVPVPPPCPPPCPPPAAPAAPPPPPCPPPPPLRSGGGPNIPPPPAGFMQAPDGAMTIKRKVQTKYKLPTINWIALKPNQVRGTIFNELDDDKLHACIDFNDFEERFKIGSTNIMSNGINETDGLQTFPSKRGKKPEHITLLEHTRLRNIAISRRKLEMTPDKVINAINMLDLKQLSLENVELLQRMVPTEQETKAYREYQFEKKNVNMLTDEDKFLLQLTKVERISAKLSIMSYIGNFFDNIHLVTPQMHAIISGSNSVKNSKKLRSVLEIILAFGNYLNSSKRGPAYGFKLQSLDTLLDTKSTDKRLCLLHYIVATIRQKFPELLNFDSELHYIEKAAVVSLENINTDVTELEKGMEAVRKEAEIRGRGSHSLVVRDFLANAEDKLRRLKSDAKMAQEAFRECVEYFAESPRTTDANTFFSLLVRFVKAFKTTDQENEQRRRLELAAQNANNKTNEDVQKRNKINQKKQQEAVINELKTKTRMVQEKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSKTLEEMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5K3</accession>
    <name>A0A6P7F5K3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114326558</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130751.1">
        <property type="nucleotide sequence ID" value="XM_028274950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5K3"/>
    <dbReference type="FunCoup" id="A0A6P7F5K3">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274950.2">
        <property type="protein sequence ID" value="XP_028130751.1"/>
        <property type="gene ID" value="LOC114326558"/>
    </dbReference>
    <dbReference type="GeneID" id="114326558"/>
    <dbReference type="KEGG" id="dvv:114326558"/>
    <dbReference type="CTD" id="36641"/>
    <dbReference type="InParanoid" id="A0A6P7F5K3"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028130751.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21220" checksum="B3EB3047FA1C8819" modified="2020-12-02" version="1">MSLTGRNRPSILDKPLSKGKGEVSLSCFALLFSEVVQYCQNKSQTVPELQNRLHELGKKIGVKLIDLYFVRERGGKREIKLLNILLFVKSTLWKALFGKEADKLEHSNDDENTYYLMEKEPLVNRYISVPRDKSSLNCAVMIAGIVEAVLTGTGFPAKVTAHWHKGTTYMVKFDDAVVTRDKNLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5X9</accession>
    <name>A0A6P7F5X9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Venom allergen 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326679</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130891.1">
        <property type="nucleotide sequence ID" value="XM_028275090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5X9"/>
    <dbReference type="FunCoup" id="A0A6P7F5X9">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275090.2">
        <property type="protein sequence ID" value="XP_028130891.1"/>
        <property type="gene ID" value="LOC114326679"/>
    </dbReference>
    <dbReference type="GeneID" id="114326679"/>
    <dbReference type="KEGG" id="dvv:114326679"/>
    <dbReference type="InParanoid" id="A0A6P7F5X9"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034763">
        <property type="entry name" value="P14a_insect"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038921">
        <property type="entry name" value="P14a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027907190" evidence="5">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="61"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130891.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28569" checksum="6B0832DADB901A93" modified="2020-12-02" version="1">MDRRIRLFYLLFVLYTVKAQTDYCQLSCGTTLQTVCERKNVSCGAGPDCIKNFKQMSLTDSDRRLVLDAHNYLRNKVATGQEPIGPQPQASNMKALSYSKELEYIAQCHTNSCKWGHDACRRTPEWGWVGQNLFLRSYKGGSITTRDMLNSSIYSLYDEVRDFNPSWVSSFDTHGKEIGHYTAIVWARTRYVGCAITFFVDDKGWDVYYLACNYGEGGNVNGWSVYEVGTPASKCDGLPKNSKYPGLCGPDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6U9</accession>
    <name>A0A6P7F6U9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional adapter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114327175</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TADA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131509.1">
        <property type="nucleotide sequence ID" value="XM_028275708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6U9"/>
    <dbReference type="FunCoup" id="A0A6P7F6U9">
        <property type="interactions" value="1261"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275708.2">
        <property type="protein sequence ID" value="XP_028131509.1"/>
        <property type="gene ID" value="LOC114327175"/>
    </dbReference>
    <dbReference type="GeneID" id="114327175"/>
    <dbReference type="KEGG" id="dvv:114327175"/>
    <dbReference type="InParanoid" id="A0A6P7F6U9"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22934">
        <property type="entry name" value="HFD_TADA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028131509.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32740" checksum="EB4CA121BA2B3592" modified="2020-12-02" version="1">MALSDLNEARNDLEACLTEDMKKEYFALLRKWFLFSSPITKEHFDSEARKILITTEQIRCHNYFILAILAKCSSNNKPKHTRSSNEKGGFENIKYSDYLQPLSPTNVAPSEFENRSAAAELFLPDSNFVGCKVAIVAWENGMKGASDKVTDLMVHACQVFVKNIITAMISRKKGYKIRDNKLQFGFNFPIPDPFIRNSNNIIDDTLECKVEVVEDEAMFKPKCKLSLESAEQKTAFAYSCAKKPCLDNSLTVKLLYDTIRNNPNILGLHSISSINTFKLSLQTFEESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F846</accession>
    <name>A0A6P7F846_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2 4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325902</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129853.1">
        <property type="nucleotide sequence ID" value="XM_028274052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F846"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274052.2">
        <property type="protein sequence ID" value="XP_028129853.1"/>
        <property type="gene ID" value="LOC114325902"/>
    </dbReference>
    <dbReference type="GeneID" id="114325902"/>
    <dbReference type="KEGG" id="dvv:114325902"/>
    <dbReference type="InParanoid" id="A0A6P7F846"/>
    <dbReference type="OrthoDB" id="6745799at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129853.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="53168" checksum="CD92AE191F1EA6D9" modified="2020-12-02" version="1">MDIEEVQSVSVRKLISAFENQTNSPEATYFRPRTRSLGNILAKNVTVRENQFATLDEISDALEVIQQQLQVYDIYNKERHVAFQEELFNILTSIINIDNDDPIRARNLISTTKHLVSVLNNKLPSNNSVEHRYTKYSEQVNGTHQSNILVKKKETSKTNNNIKRENSVDLNKDIVKSTKETKGIGLTRSVSVKKLKELFQSDIKLSELPTHQNKYESKSEQTVKVSNTLKKSSTTTTVVTVPEAVNRVIKDERVYPYQEYYPVETASKDTDYAISVANLRNVFEVKSKEASTGLPLILKEHKPPITRFNYRSSVSEEPELISYTPNKLASEESSRLLELLKRDAESSNQSFEYSLNVSEQDDAGEVTPVESPNRDENDIMSSLEYIEENDNEYDNDSISGDSLNSAESVKTVESLNSNNNSSLRLNSNYIIDDNEEDDNEDNDYNDHGVKIEEINFDDTEYLPESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8I1</accession>
    <name>A0A6P7F8I1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114325832</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129765.1">
        <property type="nucleotide sequence ID" value="XM_028273964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8I1"/>
    <dbReference type="FunCoup" id="A0A6P7F8I1">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273964.2">
        <property type="protein sequence ID" value="XP_028129765.1"/>
        <property type="gene ID" value="LOC114325832"/>
    </dbReference>
    <dbReference type="GeneID" id="114325832"/>
    <dbReference type="KEGG" id="dvv:114325832"/>
    <dbReference type="CTD" id="93210"/>
    <dbReference type="InParanoid" id="A0A6P7F8I1"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028506765" description="Post-GPI attachment to proteins factor 3" evidence="8">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028129765.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37501" checksum="F00E26FDCD80CB8D" modified="2020-12-02" version="1">MNLIIFIILATVIKCSISSAGDHSPYYQRCVERCEILNCTEDGKDFLEDKQPIILKYTLWDCSQECHHECMWKTVDAFHERDWRTPQFYGKWPFIRVLGMQEPASVIFSLLNGYFHVKMIRKFRREVRGDSPLVWLWHAFFIVSVHAWTWSAVFHYRDFPLTEILDYACAFSMVLMNCYVMAMRLLYGKLPTFGLIGITLVFILFLMSHVAYLSIGRIDYGYNIELNIAVGTFTALCWFVWCFYNRSSHKYVWKCAIYVAISGLVLLLELIDRPPIYFTVDYHALWHLSTAPLIVFVYGFAIDDCKYLRNKKDLAKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB51</accession>
    <name>A0A6P7FB51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Alpha-amylase</fullName>
            <ecNumber evidence="6 15">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114328464</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="6 15"/>
    <dbReference type="RefSeq" id="XP_028133124.1">
        <property type="nucleotide sequence ID" value="XM_028277323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB51"/>
    <dbReference type="FunCoup" id="A0A6P7FB51">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277323.2">
        <property type="protein sequence ID" value="XP_028133124.1"/>
        <property type="gene ID" value="LOC114328464"/>
    </dbReference>
    <dbReference type="GeneID" id="114328464"/>
    <dbReference type="KEGG" id="dvv:114328464"/>
    <dbReference type="InParanoid" id="A0A6P7FB51"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028356669" description="Alpha-amylase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="30"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="17">
        <location>
            <begin position="393"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028133124.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="52456" checksum="DCDB8E0D0CAFED87" modified="2020-12-02" version="1">MKIVILFCALSVTVSSVIGQKDNHFAQGRNTIVHLFEWHWDAIASECENFLGPKGFAGVQVSPPNENSVIGDRPWWERYQPVSYQLTTRSGDESAFANMVQRCNNVGVRIYVDVVFNHMSATSGGGTAGGSCDVGSLSYPSVPFGSNDFHSKCDVNNYQDANNIRNCWLSGLPDLDQSHDYVRQKIVEYLNHLVDLGVAGFRVDAAKHMWPADLEAIYGSVKDLTGSGLSGRPFIYQEVIDLGGEAVKKTEYNSFGTVLEFKYGTELGNAFQGHNALHWLENWGPAWGLLAGTDAVAFIDNHDNQRDGSSAILTYKNPKPYKMAIAFMLAHPYGTTRLMSSYAFDSHDQGPPGQQPGFNADGTCTNGWVCEHRWREIFNMVGFRNAVAGTDVTNWWSDGNQQIAFGRGNKGFIAFTLQGDINQSIQTSLPAGTYCDVISGSLENGSCTGKTVNVDGSGKAAISLSTNEDDGVVAIHVNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDL5</accession>
    <name>A0A6P7FDL5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114328289</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132912.1">
        <property type="nucleotide sequence ID" value="XM_028277111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDL5"/>
    <dbReference type="FunCoup" id="A0A6P7FDL5">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277111.2">
        <property type="protein sequence ID" value="XP_028132912.1"/>
        <property type="gene ID" value="LOC114328289"/>
    </dbReference>
    <dbReference type="GeneID" id="114328289"/>
    <dbReference type="KEGG" id="dvv:114328289"/>
    <dbReference type="InParanoid" id="A0A6P7FDL5"/>
    <dbReference type="OrthoDB" id="10048380at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039714">
        <property type="entry name" value="TMEM134"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13558:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028132912.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19614" checksum="FA69E20E40AB4090" modified="2020-12-02" version="1">MSYQFSLTNGKQKRFSIDDAFEEETDEAIKVYGTAGPRSPISGSRIMVGDGDHVAVNMENGRSYKMANDTSRDSDSLIQDYYDCPNEENFSRSCFKHPKVKENWRMVLAAATLLIIGIGLLATGSVTLAEPNSGLQGLVFLLAGFICFLPGAYHIVYIYLAAKGKRGYHFHNLPLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDW0</accession>
    <name>A0A6P7FDW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC114329331</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21 22">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134188.1">
        <property type="nucleotide sequence ID" value="XM_028278387.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028134189.1">
        <property type="nucleotide sequence ID" value="XM_028278388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDW0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278387.2">
        <property type="protein sequence ID" value="XP_028134188.1"/>
        <property type="gene ID" value="LOC114329331"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278388.2">
        <property type="protein sequence ID" value="XP_028134189.1"/>
        <property type="gene ID" value="LOC114329331"/>
    </dbReference>
    <dbReference type="GeneID" id="114329331"/>
    <dbReference type="KEGG" id="dvv:114329331"/>
    <dbReference type="CTD" id="36849"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
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    <sequence length="608" mass="67803" checksum="240CE6B459B5373B" modified="2020-12-02" version="1">MSCKQTLRNSPRGTPDIPLTTTDGRETWSKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYCIMLVIGGIPLFYMELALGQFNRKGAITCWGRLCPLFKGIGYAVVLIAFYVDFYYNVIIAWALRFFFASFTNLLPWTTCDNPWNTPNCRPFEFPTRNYSDFNRSELAEITGPSDSRFASAASEYFNRAILELHQSEGLHDLGAIKWDIALCLLAVYVICYFSLWKGISTSGKVVWFTALFPYAVLLILLVRGITLPGSAEGIQYYLNPNFSAIGSAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSVINSATSFIAGFVIFSVLGYMAHAAGRPIQEVATEGPGLVFIVYPAAIATMPGSIFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIGRNREIFVACLFTLYFLVGLASCSQGGFYFFLLLDRYAAGYSMLFAVFFEAIAVSWIYGTQRFCDDIQDMIGFSPGYYWRFCWKFAAPVFLLFIIVYGLLGYEPLSYENYVYPGWANILGWVIAGSSVFMIPAIGLYKFIVTPGSCLKRLKTLTTPWRDTQRASQVNGVVQSESQQVRLSTPEVPNQAPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ11</accession>
    <name>A0A6P7FJ11_DIAVI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="gene ID" value="LOC114329908"/>
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    <dbReference type="KEGG" id="dvv:114329908"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22547">
        <property type="entry name" value="SP6-9-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SP1, ISOFORM F"/>
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    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028134982.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="49865" checksum="CDA5B9AFB9D16DD7" modified="2020-12-02" version="1">MLTDMTPTAGQLYGAQIPAMTMNVKTADHPSLRGTPLAMLAAQCNKLSSKSPPPLADAAVGKGFHPWKKSPQGAPSPGSTCVSSSSSLSSQRSSASNPTYSRSVMTSCSSVPTTASYGSDLYFPGATTQPAVADNSHVHHHQSSLLGKVEGAATAHHAALGSVYSRHPYETWPFNTMSSATHHTGIKSDSVASANAWWDVHSTAGSWLDMSGAAGMHAQMAAANYSPDYSSLTHSLAASNHLLSSGQHLLQDTYKSMLPGAQSVGASFGLHAPGSTPSPTGGTGGLPPQVPSPRSQRRYTGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGNGKKGSSDSCSDSEENSQSDLTNNVNSPASMNQTPPPPTNMGLDMVTGLDVKPPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FM68</accession>
    <name>A0A6P7FM68_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose dehydrogenase [FAD, quinone]-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329241</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134088.1">
        <property type="nucleotide sequence ID" value="XM_028278287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FM68"/>
    <dbReference type="FunCoup" id="A0A6P7FM68">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278287.2">
        <property type="protein sequence ID" value="XP_028134088.1"/>
        <property type="gene ID" value="LOC114329241"/>
    </dbReference>
    <dbReference type="GeneID" id="114329241"/>
    <dbReference type="KEGG" id="dvv:114329241"/>
    <dbReference type="InParanoid" id="A0A6P7FM68"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF226">
        <property type="entry name" value="RE28171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134088.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="69683" checksum="AEFFE703E32407CB" modified="2020-12-02" version="1">MSALAAIGQIASLAIGVTTNPLTILGLVPVFAAGLTFMRYLSMDPEVHPRNTVNVRPEYDFIVIGGGSAGAVVASRLSEISNWTVLLIEAGGDENEVSDIPTLSGYMQMSHMDWMYQTSPPGDSPYCLAMLGDRCNWPRGKVLGGSSVLNAMVYVRGNRQDYDYWEAQGNPGWSYDNVLPYFLKSEDNRNPYLSKTPYHQTGGYLTVQESPWRTPLSIAFLQAGRELGYQIRDINGEIQTGFMLTQGTIRRGSRCSTAKAFLRPVRNRPNLHIAMHAQVTKIKINPKTKEAFAVRMIRNNRPQTIRARREIILSAGAIGSPQLLMLSGVGPKEHLESFKIPVLSDLKVGHNLQDHVGLGGFTFTIDDPISFTKKRYQTWQVALEYIMNEKGPMTSIGGVEGLAFVNTKYAPKSGLWPDIQFHFAPSSVNSDPDQVRKITGLRDSVYNTVYKPLRDTDTWTILPLLLRPRSTGWIRLKSIDPMVYPDINPNYFTHKEDIATLTEGIRIALNVSASQAFQRFNSKPHKIPFPGCRQYAFDTDEYWECSIRHFTFTIYHPTSTCKMGPATDADAVVDPRLKVYGIGRLRVVDASIMPTIVSGNTNAPTIMIGEKASDMIKEDWGIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNT8</accession>
    <name>A0A6P7FNT8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 6 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114329704</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028134688.1">
        <property type="nucleotide sequence ID" value="XM_028278887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNT8"/>
    <dbReference type="FunCoup" id="A0A6P7FNT8">
        <property type="interactions" value="1384"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278887.2">
        <property type="protein sequence ID" value="XP_028134688.1"/>
        <property type="gene ID" value="LOC114329704"/>
    </dbReference>
    <dbReference type="GeneID" id="114329704"/>
    <dbReference type="KEGG" id="dvv:114329704"/>
    <dbReference type="InParanoid" id="A0A6P7FNT8"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="6">
        <location>
            <begin position="292"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028134688.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="68651" checksum="51D55657ACEFDC8B" modified="2020-12-02" version="1">MAEIVEGRMESMTEIQEMRRLKLFSIIETKDIIKKRKAFECKLNGVEKNLQHFKDYINYELSLLKDIKLRRKKLKISENKDKIEIRILNNIKSRYEIALQRFTNEMNFHLEYFKFCREYNFHQAACLCVQNMIKAYAHVPDIWLAAAAYYVSRDTKQSLALIHKGIAIHPSSQALQLEAIQLELLQRQENQYPSDTQCDTLDDAYYKKIEQYIDAVEKNIHDHACLISILNILDPHNFTEKIQHRIIELLMSKYSNEPDVWHFLAEREQNGKHYPVPDELRTSTKFKLQRLIDKYELGLRKISIEKKVALWTYYLDFLIELNELKDISNHMIKSTLKEKLQDAKRDSVLNERYYLTWAKLYTEESDILRIIEDGLAALPNSLALWKKKLICMTMRDDVKALNVEFKKGHMALKENSTPLWIILIKYHLLNSPEKVVETIYRDACHQHGSIANEFKGDFVEWAALNKGIEDTRKVYQDLAFRSPFCKDLHIKMAKLEETELIVSAKDMEHPLNLLCKQFGKDDPDCWIALRDCYLNHQTLFENAYPAFNINTKLAQIRTEALKSIGDSGPTKAEFLAKYDTASFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQE5</accession>
    <name>A0A6P7FQE5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myelin expression factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114332872</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138456.1">
        <property type="nucleotide sequence ID" value="XM_028282655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQE5"/>
    <dbReference type="FunCoup" id="A0A6P7FQE5">
        <property type="interactions" value="1941"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644651.1">
        <property type="protein sequence ID" value="XP_050500608.1"/>
        <property type="gene ID" value="LOC126880631"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FQE5"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="462"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028138456.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="58401" checksum="2495E74F1332DDE0" modified="2020-12-02" version="1">MSESPKDRRGRDRDRPRNNRDNRNNKGDNSRERSNDRGPREPRSMRPSQNRVYVSNIPYEYRWQDIKDLFRSKIGDVTFVELFVDDNDKPRGSGIVEFNDSDLVGKCLELMQRYEVKGRKLVVKDDQGITRDKFGAIVSNQGGGKRREYNRFNDNMNSMNIDLGNTLNLGNDKWGNTYGLSPQFLESLKIDPPLNNKVFVANLDYNIDKKKIKDVFKLAGRVINVDMPLDKDGKVRGFAVVEYDHPVEAVQAISMLQGQVLNDRTLAVRMDRVNDNSKLPEGLRSVGMGLGPNGEALKNVAHNLPSLGSGSQGGTTGSGLLGAVPNSSLQLANALSGLGNVGNLAGLNQNFSGLASTLLGNGLGATELSSLVQNPLSAQNSATQQLSGLNNQNSTSGNLGNFNRGSSGDNYGNQNSNNWSSNNNSSNGGGRNFQSGNNNYGGNDRMSFNGTRQDGGGKSFSRKVLISNLPTSASYKLLHEKFTEFGDVHGFEEKMHGSVLVTYGSDWQAERAIKNLDKARIDGRMIDARLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTN7</accession>
    <name>A0A6P7FTN7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid droplet localized protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114333889</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139686.1">
        <property type="nucleotide sequence ID" value="XM_028283885.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497993.1">
        <property type="nucleotide sequence ID" value="XM_050642036.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497994.1">
        <property type="nucleotide sequence ID" value="XM_050642037.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497995.1">
        <property type="nucleotide sequence ID" value="XM_050642038.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497996.1">
        <property type="nucleotide sequence ID" value="XM_050642039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTN7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642036.1">
        <property type="protein sequence ID" value="XP_050497993.1"/>
        <property type="gene ID" value="LOC114333889"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642037.1">
        <property type="protein sequence ID" value="XP_050497994.1"/>
        <property type="gene ID" value="LOC114333889"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642038.1">
        <property type="protein sequence ID" value="XP_050497995.1"/>
        <property type="gene ID" value="LOC114333889"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642039.1">
        <property type="protein sequence ID" value="XP_050497996.1"/>
        <property type="gene ID" value="LOC114333889"/>
    </dbReference>
    <dbReference type="GeneID" id="114333889"/>
    <dbReference type="KEGG" id="dvv:114333889"/>
    <dbReference type="InParanoid" id="A0A6P7FTN7"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028139686.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47418" checksum="5190731FC9F1D4DF" modified="2020-12-02" version="1">MAERLDLLLFGATGVTGLHAIRYLHKFSKEKKLTWGISGRSETKLKAVLKNEGLRMGEDLSKIPIVLADTKDQKSLNEMAKKAKVLLNCCGPYRLLGFPVVEACIKAGTHHLDVSGEPSYIDSLPEKYDAAAKEKGIYIVSACGVDCVPTDLGSAYLQQKFDGVLNSVVAYVELWTEGKSSGSVGGYGTWQSLVYEFQTMGSLSKLKAKLIPPSDSAFKPTLPVKIRPFYSEVTKGWVMPFAGHDRKIMQETQKYFYEKESQRPINGQVLMSVTSIFTLIYINIVLLTLFALAQFSFTRNWLIEYPQIFSFGYVKKEEHPSEEVKAGGRYRLTLYGEGWKEKLANVNDQYAMPPNRSILAQLQFENFYTFTVLGLMCAGIAILNEKDKLPKSGGVYSAGAAFGKTSLMKMLIENGTSFEIKSVKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUG2</accession>
    <name>A0A6P7FUG2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin-associated protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140079.1">
        <property type="nucleotide sequence ID" value="XM_028284278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUG2"/>
    <dbReference type="FunCoup" id="A0A6P7FUG2">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284278.2">
        <property type="protein sequence ID" value="XP_028140079.1"/>
        <property type="gene ID" value="LOC114334241"/>
    </dbReference>
    <dbReference type="GeneID" id="114334241"/>
    <dbReference type="KEGG" id="dvv:114334241"/>
    <dbReference type="CTD" id="32071"/>
    <dbReference type="InParanoid" id="A0A6P7FUG2"/>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140079.1"/>
        </source>
    </evidence>
    <sequence length="843" mass="96515" checksum="08E5298E19D203C6" modified="2020-12-02" version="1">MVIEIICFNIFIVFLLITFKGVYHCIVFICKIIFEMEPEDAKFMRTERKPGSVDVHPNIDAICLNYDLDIQILASKEHVIYGEKKSLKKIIELPMINSRTDCHVLSKEVVNQCELIHHSRLPEVEQIIYYLKKRKLQNGGKGMGPMGDGDKNKFDNYSNGVHEANYNSLSEYIDLLYEGMAEKIRGAQLIQLLARDPENLEALATNETLISALGRVLREDWKRSIALSTHLVFTFFCFSIYSCFHHVILKCKVGSICMDIIDYELRRYDRWKADFEGAEAPSDIPIVRKPCPSSASMSEIPRSRIPEPVRPKSGNFSDSNISQIMEGSIYDDLTTSMEGIDDRKLTGEQKLKRFRTLVKKQEHLLRVAFYLLLNIAEDEVVEEKMSKRNIVGLLAKALERENEDLLILVITFLKKLSIMQCNKEVMVGNMCVIEKLPRMLNSSSADLVHLTLKLLFNLSFDNKARYKMIKAGLLPKVISLLSDDKHQEVVLKILYHLSYEDEIKHHFVDCIGLIIDMLLLSVGNENDKTMVALCVNLSTDQSNAQHIIKKNRLQSLIMRSFTYQDAMLMKMLRNISDNPVCAPAFIEFVGDIAKTVVDSKNEDFSRECVGILSNLYLPDLDWAEIFKHFDMVTWVKNIITGNNRDAELVLHVIVLLGTAATDEGCSNLFCETGMLALLIDLLKTYQEDDEVVLQIVYVFLVALSHSSNIEHIITKTEAPAYLIDLLQDNNKIIGKLCNTCLNIISEHDKTWADRIRIEKFRNHNQQWLAMVDSQQLETEEEEEDELPPYLNTEYLSTAVVPPLTDLQDNAETEIISDKDLDCNYFDEKLTEEEEEMMQEIGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVE0</accession>
    <name>A0A6P7FVE0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Testis-specific serine/threonine-protein kinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114334591</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140464.1">
        <property type="nucleotide sequence ID" value="XM_028284663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654796.1">
        <property type="protein sequence ID" value="XP_050510753.1"/>
        <property type="gene ID" value="LOC126887345"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FVE0"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14080">
        <property type="entry name" value="STKc_TSSK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000943">
        <property type="entry name" value="testis-specific serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028140464.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="39582" checksum="8CBBB60354A55893" modified="2020-12-02" version="1">MATHLSPRNSEVNALEQRGYLIGKKIGQGSYATVHLADYVDNTGPKKMRLACKIFDKEKAPKDFLEKFFPRELEILTKIENQHIIQVHSILQRGPRVFIFMRYADNGDLLDFIKKNGVVPEQQAKIWFRQMASGLHYLHGRNIAHRDLKCENILLSRRFNVKLADFGFARFCVDSDNRRILSQTYCGSAAYAAPEVVNGTPYNPKLSDVWSLGIILFIMLNASMPFDDSNLRKLLKDQMTKNWVFRSRVRDSLSTLAKSLVRHLLEPDLTQRLTLERIMQHEWLRMRRERPSLIGRLVHNPGENHFPHVSCAYDDEKVPGDFQNPDNKKSEMRIAINDNSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXS5</accession>
    <name>A0A6P7FXS5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">LOC114335261</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141271.1">
        <property type="nucleotide sequence ID" value="XM_028285470.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141272.1">
        <property type="nucleotide sequence ID" value="XM_028285471.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141274.1">
        <property type="nucleotide sequence ID" value="XM_028285473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141275.1">
        <property type="nucleotide sequence ID" value="XM_028285474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXS5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646462.1">
        <property type="protein sequence ID" value="XP_050502419.1"/>
        <property type="gene ID" value="LOC126878423"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646468.1">
        <property type="protein sequence ID" value="XP_050502425.1"/>
        <property type="gene ID" value="LOC126878423"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="12">
        <location>
            <begin position="322"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028141271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028141272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028141274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028141275.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="59945" checksum="F09D1FB9714AB715" modified="2020-12-02" version="1">MSTINTNAPSSADACLSIVHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTSGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCQFAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSGTPRLVKDEYTPGAVAGNSMDIDGDIAIKFSQTIQHHPPQQNFTISGLQSPPTSQNPVQQPIPPEPIPQNLTNNSPVSPHIQQNEFTNTNNTTVVASNNNGTVSSTQSTNTIGQNFTGASGTWNGSNTLTYTQSMQPPDNRSHTAYWISSPNQINSEVSIGGLLSTQPAPEYWCSVAYFELDTQVGETFKVPSNCPNVTVDGYVDPSGGNRFCLGALSNVHRTEHSERARLHIGKGVQLDLRGEGDVWLRCLSDHSVFVQSYYLDREAGRQPGDAVHKIYPGAYIKVFDLRQCHHQMTTQAATAQAAAAAQAAAVAGHIPGPHSVGGIAPAISLSAATGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHTMPIDGPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYC7</accession>
    <name>A0A6P7FYC7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase inhibitor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141584.1">
        <property type="nucleotide sequence ID" value="XM_028285783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYC7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645796.1">
        <property type="protein sequence ID" value="XP_050501753.1"/>
        <property type="gene ID" value="LOC126881505"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FYC7"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141584.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19306" checksum="773659E3C02F60A2" modified="2020-12-02" version="1">MAENLKRRPRKGILKNSSSFDKQDPQFNAKKQKETKWDEMNIIATLHPADKDYGHMKIQEPKTPFNYMEQDNIEELDASELAERIRIATEQPPKVMQQDDSDDDSEEELTDDQKKKKKDFELKRKKHYNEFHALQLAKKLMEEEEDDEDEGTHHNSSDNQPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3D3</accession>
    <name>A0A6P7G3D3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114337222</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43457"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028143431.1">
        <property type="nucleotide sequence ID" value="XM_028287630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287630.2">
        <property type="protein sequence ID" value="XP_028143431.1"/>
        <property type="gene ID" value="LOC114337222"/>
    </dbReference>
    <dbReference type="GeneID" id="114337222"/>
    <dbReference type="KEGG" id="dvv:114337222"/>
    <dbReference type="InParanoid" id="A0A6P7G3D3"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016937">
        <property type="term" value="F:short-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF26">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="143"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="250"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028143431.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="43520" checksum="5A273B94CD0011A1" modified="2020-12-02" version="1">MSLSSTSQILCKGTTAIISRCFSLHKLPETHKLLQKTCRDFAEKELKPIAALLDREHKFPEQQINKLGELGILGICVSKEYGGAGYDGLGMAVAVEEISKGCAGTGAIVSIHNCLYASLLDRLGTPHQKEQYLRAFTKGTLGCFALSEPDAGSDVGAMSCTADKDGDHYILNGNKSWVTSGLQGKAAVVFATVDKGLKHKGITAFIVPIPSQGLTLGKKEDKLGIRASSTCNLILEDVKVPKENILGPIGGGFRIAMEQLDRARVGIAAQAVGIGQAALDLAARYSLQRKAFGKTISELDAVKLRLGEMALRLESARLLVWKAAVLCDDPSRTTKETSMAKLAASEAATFITHGAIQVLGGMGYVSDMPAERHYRDARITEIYGGVNDIHRMLVGSSVVKEYEIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G463</accession>
    <name>A0A6P7G463_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114337523 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114337523</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143784.1">
        <property type="nucleotide sequence ID" value="XM_028287983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G463"/>
    <dbReference type="FunCoup" id="A0A6P7G463">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653785.1">
        <property type="protein sequence ID" value="XP_050509742.1"/>
        <property type="gene ID" value="LOC126886760"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G463"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332">
        <property type="entry name" value="PROTEIN CBG11604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38332:SF1">
        <property type="entry name" value="RE49668P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028190336" evidence="3">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028143784.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17975" checksum="152FD83D7ECB1FB6" modified="2020-12-02" version="1">MIKLLLAFHLLHTAFVYSIDCFKCISVNNDFVPCEDPFHHNFTNDIYQSPCMGGKKGRDGLFPATSCIKIAGIFDDTEDAIVVRGCALDSGTLTTDTEIVRMSHCGSFYYENRYVRGCVQSCNDADGCNKGAQEKLNSWTILLSMFLAKVYPLCYKLYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6W2</accession>
    <name>A0A6P7G6W2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114338420</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144821.1">
        <property type="nucleotide sequence ID" value="XM_028289020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6W2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289020.2">
        <property type="protein sequence ID" value="XP_028144821.1"/>
        <property type="gene ID" value="LOC114338420"/>
    </dbReference>
    <dbReference type="GeneID" id="114338420"/>
    <dbReference type="KEGG" id="dvv:114338420"/>
    <dbReference type="InParanoid" id="A0A6P7G6W2"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028144821.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13272" checksum="799B63BCB56E2223" modified="2020-12-02" version="1">MTGHHPQFGNLFHLRNIVFYKMSPYHVRLFPSFRIKNTIRRICYEAPWVVTPLAVACLVYYSMDNLHEKYQRKIPGQFDDEDNTNSQNNNNKNNNNNKNKNNNNNNNNNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8P7</accession>
    <name>A0A6P7G8P7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114339052</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145479.1">
        <property type="nucleotide sequence ID" value="XM_028289678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8P7"/>
    <dbReference type="FunCoup" id="A0A6P7G8P7">
        <property type="interactions" value="1088"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289678.2">
        <property type="protein sequence ID" value="XP_028145479.1"/>
        <property type="gene ID" value="LOC114339052"/>
    </dbReference>
    <dbReference type="GeneID" id="114339052"/>
    <dbReference type="KEGG" id="dvv:114339052"/>
    <dbReference type="CTD" id="10898"/>
    <dbReference type="InParanoid" id="A0A6P7G8P7"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000005">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000019">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028145479.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="32145" checksum="3F5E63846246CE4F" modified="2020-12-02" version="1">MECVIANVDHIKFDIEVALEEQYGALPLPFQGMDKSTAAVCLFFSTINGCKKGPQCPFRHVRGDRTIVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSRFNACHNKECPFLHIDPESKIKDCPWYDRGFCRHGPHCRHRHVRRVLCTNYLAGFCPDGPKCKYMHPRFELPAPPDQQKEQKKTICHFCGEHGHKAIHCNKMVDPTKVLFLQDEKSQENNAEPTSQNLYLQKMLPKRLEDVTCYKCGTKGHYANRCPKGHLAFLSQSKKETENNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAL3</accession>
    <name>A0A6P7GAL3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immediate early response 3-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114335425</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141465.1">
        <property type="nucleotide sequence ID" value="XM_028285664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAL3"/>
    <dbReference type="FunCoup" id="A0A6P7GAL3">
        <property type="interactions" value="1317"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285664.2">
        <property type="protein sequence ID" value="XP_028141465.1"/>
        <property type="gene ID" value="LOC114335425"/>
    </dbReference>
    <dbReference type="GeneID" id="114335425"/>
    <dbReference type="KEGG" id="dvv:114335425"/>
    <dbReference type="InParanoid" id="A0A6P7GAL3"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027907455" description="Immediate early response 3-interacting protein 1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028141465.1"/>
        </source>
    </evidence>
    <sequence length="85" mass="9479" checksum="EE0B3FF8DF40A833" modified="2020-12-02" version="1">MAFSLWNLFEASLLFLNAVCILNEERFLSKIGWSSRTGGANIQGFGENPSTKSQIYTLFHSIRTVARIPLIVINLLVIVLKLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBG5</accession>
    <name>A0A6P7GBG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Spastin</fullName>
            <ecNumber evidence="9">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114336065</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
            <location evidence="9">Microtubule organizing center</location>
            <location evidence="9">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
        </subcellularLocation>
        <text evidence="9">Forms an intramembrane hairpin-like structure in the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the AAA ATPase family. Spastin subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028142183.1">
        <property type="nucleotide sequence ID" value="XM_028286382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBG5"/>
    <dbReference type="FunCoup" id="A0A6P7GBG5">
        <property type="interactions" value="1518"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286382.2">
        <property type="protein sequence ID" value="XP_028142183.1"/>
        <property type="gene ID" value="LOC114336065"/>
    </dbReference>
    <dbReference type="GeneID" id="114336065"/>
    <dbReference type="KEGG" id="dvv:114336065"/>
    <dbReference type="InParanoid" id="A0A6P7GBG5"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031117">
        <property type="term" value="P:positive regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02679">
        <property type="entry name" value="MIT_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19524">
        <property type="entry name" value="RecA-like_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03021">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017179">
        <property type="entry name" value="Spastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="69"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="14">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="405"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028142183.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="71713" checksum="6B3CEB273037B2DC" modified="2020-12-02" version="1">MVRKNQSGKSPKKSRKSDPDASHSNVMFTSYSTTSVHKRNLCIVSFPIIFLFNVLRSLLYQIFVILRFVYCSSSTYFVRHQIADCENGERNNCVVIEEVSEMAQAKSTGPGPGDPLLAKQKHHHRRAFEYISRALKIDEENEGQKELAIDLYRKGITELELGIAVQCWGGRGEVWERAQRLHEKMKTNLAMAKDRLQFLESMDRLHNLEVNQPQDTPKYSYSSNIPAPKTNVSKPGTNPTQFSKLFGSLTALLDNTTSGKKLTVASKRPANSPLSKSLTLPRSMGSRNTPVQPVRPFNKISSTPPAVKKQLSVPGNAGSPARKVNSGNNINAAAGTSKQGQRVRSPSLRGVDPKLAHAILDEIVEGGPAIQWEDIVGQDTAKQALQEMVILPSLRPELFTGLRTPARGLLLFGPPGNGKTLLARAVATECQATFFSISAASLTSKYVGDGEKMVRALFAIARELQPSIIFIDEVDSLLSERSNNEHEASRRLKTEFLVEFDGLPSNPESEKVLVMAATNRPQELDEAALRRFPKRVYVSLPNLETRAKLLKKLLAKQGCTLTQQELKRLATLTEGYSGSDLTALAKDAALGPIRELQPEQVKQLDPNAVRSITINDFLDSLKRIRRSVSPQSLVAYEKWSLQYGDVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBR0</accession>
    <name>A0A6P7GBR0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Junctophilin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114340172</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146694.1">
        <property type="nucleotide sequence ID" value="XM_028290893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659386.1">
        <property type="protein sequence ID" value="XP_050515343.1"/>
        <property type="gene ID" value="LOC126890442"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GBR0"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000012">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF16">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028146694.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8344" checksum="6EAC396FFCE0FC6B" modified="2020-12-02" version="1">MQTQPAENGATSTGATGTATTRSHVNGGRFDFDDGGTYCGGWEEGKAHGHGVCTGPKGQGAYSGSWHYGFEVSGVYTWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBU5</accession>
    <name>A0A6P7GBU5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114340295</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates sugar transport across membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146831.1">
        <property type="nucleotide sequence ID" value="XM_028291030.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498588.1">
        <property type="nucleotide sequence ID" value="XM_050642631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBU5"/>
    <dbReference type="FunCoup" id="A0A6P7GBU5">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642631.1">
        <property type="protein sequence ID" value="XP_050498588.1"/>
        <property type="gene ID" value="LOC114340295"/>
    </dbReference>
    <dbReference type="GeneID" id="114340295"/>
    <dbReference type="KEGG" id="dvv:114340295"/>
    <dbReference type="InParanoid" id="A0A6P7GBU5"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF5">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028146831.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25316" checksum="28BA8F6EFD9FD865" modified="2020-12-02" version="1">MEALSNILQPYKNVVGQTASIVTIAQFFSGAFICKDIYKKKSTAGIQAVPFIGGITIGILMLKLALLMNDAAMLQVNVAAIGLNVLYLAFYYYYSADKYNEVLKPGSVGVAIVAVFIGYSLVEAPELLEYRYSLVVTILMLALIGAPLLDVKAIIDKRDASSIPFPLTFMGTIVTALWLIYGIILQNAFMIVQNVIGFLLCLVQLVLIFKYPGPSGQTKNKAKSKKKSAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCE9</accession>
    <name>A0A6P7GCE9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LOW QUALITY PROTEIN: transmembrane emp24 domain-containing protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114336375</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142533.1">
        <property type="nucleotide sequence ID" value="XM_028286732.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7GCE9">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286732.2">
        <property type="protein sequence ID" value="XP_028142533.1"/>
        <property type="gene ID" value="LOC114336375"/>
    </dbReference>
    <dbReference type="GeneID" id="114336375"/>
    <dbReference type="KEGG" id="dvv:114336375"/>
    <dbReference type="InParanoid" id="A0A6P7GCE9"/>
    <dbReference type="OrthoDB" id="5976732at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028439267" evidence="11">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028142533.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26758" checksum="93635988B107E23C" modified="2020-12-02" version="1">MNYFLLYIFLFILHQVNSLEKEITVYVEAGTESCFYQPIKKGEIVDLDYQVIDGGHGDLDINFNLVHPNDXILLTDFKKSENTHRLDAEVEGDYRFCFDNSFSSYNTKTVFFELIVEGDDNGEWSSENMKFNTEDEDFEAQISDVQKIVSTVRIHLTKIRYLQELIKSSEARDRNIAEENFFKVNSYSMVQLSLMIIVGFIQVVMVRSLFDDHSRVHKIWKNLDKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD02</accession>
    <name>A0A6P7GD02_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein LPCP-23-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114335999</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142100.1">
        <property type="nucleotide sequence ID" value="XM_028286299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GD02"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286298.2">
        <property type="protein sequence ID" value="XP_028142099.2"/>
        <property type="gene ID" value="LOC114335998"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GD02"/>
    <dbReference type="OrthoDB" id="7493332at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028041039" evidence="1">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142099.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028142100.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="20311" checksum="956F4E868DB61B95" modified="2020-12-02" version="1">MAFKVLVFAALVAYVNAGIFGEAPVAAPVVSAYSAAPVVAAAPVVAAPAAVSRSYIQTYSSHSAPLAVAAPVVAKSVAPVVSAYSAPLALPAAAPVISSYSAPVVAKSVGPVAYSAHAPVVSAYSSPLVAQSVSPVAYAAPAPVLSAYSSPVVAKSVAPLSYAAPAPVLSAYSAPVVARSFAPAPLAYAAHGSPLVSAYSSGPLVQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJG1</accession>
    <name>A0A6P7GJG1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114338916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114338916</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145348.1">
        <property type="nucleotide sequence ID" value="XM_028289547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJG1"/>
    <dbReference type="FunCoup" id="A0A6P7GJG1">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657428.1">
        <property type="protein sequence ID" value="XP_050513385.1"/>
        <property type="gene ID" value="LOC126889298"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GJG1"/>
    <dbReference type="OrthoDB" id="47883at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF13">
        <property type="entry name" value="LD14533P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin-like" evidence="2">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028145348.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36792" checksum="FE04A21B10209D05" modified="2020-12-02" version="1">MYTDKICVKETDQLKTSIHNLNKFYIESGCLLKDLEQSFKIAYKSIFLIIFVSATVLSILLNGEYCILALNYIFGVRCLLPNNYFIWEATRPISNCNFCLNVTEPIILPNVSRETFLPYNYGSKPVVIKEAFLHWPAMHVFSLEYFQKLYNNIEGSIRSVNEECQFLHFKSDFISVKDVFLMSEERSRNEPTEKSWYVGWGNCHPTILEEMRKHYPKPHFLPEDSEIPSKEYIFMGYDDGATLHLDFINRLMWQAQLKGTKRWYLHPPPECESMCKPLSFYVEPGDAVLVDTRVWYHGTTIKPGEFSLSVQSEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJV7</accession>
    <name>A0A6P7GJV7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114339763</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146242.1">
        <property type="nucleotide sequence ID" value="XM_028290441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJV7"/>
    <dbReference type="FunCoup" id="A0A6P7GJV7">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290441.2">
        <property type="protein sequence ID" value="XP_028146242.1"/>
        <property type="gene ID" value="LOC114339763"/>
    </dbReference>
    <dbReference type="GeneID" id="114339763"/>
    <dbReference type="KEGG" id="dvv:114339763"/>
    <dbReference type="CTD" id="42340"/>
    <dbReference type="InParanoid" id="A0A6P7GJV7"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF83">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="170"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="413"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028146242.1"/>
        </source>
    </evidence>
    <sequence length="1067" mass="123650" checksum="8D4A53B373D8954D" modified="2020-12-02" version="1">MSSGKKNVSVLLQSPTQSTPLLPESSSSTVYFSNKEKTEETPLFITGENGINGSSKVLDGFSQNSVKSQNSKPFIYETKIYQCDTDSESQSDFDAMSIVSRYNSGENLEDEMNTERDFMEKPATIQDILGETPISNNISQNNQKEKHECPCCKNSSRLCNAVKCATPKIFFDDGVKSVDFVLVWDSSDHHATLEESYDKRQTFERNLRKEGLELEHAHPEQNGLNFIKVHVQKEVLRRYSEILKLRMPMKEVFCKTPEETERVNLFSSIGQKIPALRQISRQTNFLIDGITDQWDKLRTWVFVDENTFPNKAHRFTAIYSRDKEYLFDVNSPYFFTPAIRSRIVQFILDRKRYSDNNNDFDFGLERLLNEKVYSAGYPLHDGDLKHSDSARSLLYIEWAALKRWYRYQPLDYVKEYFGVKIGFYFAWLGFYTHMLIPAAIVGLLCFVYSCATLYNNIPTEDICHEKIKEKMCPQCDVWCDYWNISESCVHSRITYLFDNPTTVFFAVFMSIWATLFLEMWKRYSAEITHRWDVSGFDIQEEHPRPQYLARLAHVKKKEVNVVTNTMEPRVPFWKLRVPMTILSFSVVLLLITLALATVVAVVMYRMSVLVSLKAFNPSSAVVVDNSSAMLFTTCTAACINLVFIFIFNYIYSYIAEYLTEYELLRTQTEFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGYPKEYNTIYGYRQEECGTGGCLTELCIQLAIIMVGKQAMNTILEMLFPLFYKWLNTLKVKTGLTKEQLSCKHCRPQWVKDYKLVTWGPRGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNVLEMRLDAKKLLTFYRRPVSQRVRDIGVWYRILDSIGKLSVITNGFIIAFTSDFIPRLVYLSTHDGLENYLNSTLAYFNTSDFKENSRPKNWESESVCRYLDYREAPGTPNEYNRTTLFYQILAARLFFVLIFENLVVLVLIVVKWLIPDIPADLKDRIRREAYITNEIIIKQETRRAQCGIVCETPTELEKIKNLNEAPSSPEQWDRVLSRSMTATLFDSPTKSSGPSNPSQESQPSPISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GM20</accession>
    <name>A0A6P7GM20_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromobox protein homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114340466</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147012.1">
        <property type="nucleotide sequence ID" value="XM_028291211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GM20"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650613.1">
        <property type="protein sequence ID" value="XP_050506570.1"/>
        <property type="gene ID" value="LOC126884609"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GM20"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028147012.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31818" checksum="89B491387DE16FEC" modified="2020-12-02" version="1">MKRRGVKKAQKAEDDSNGVEDFVEKNGGASDVEDESDEQPKDKKRKSKSNRKSASPSKKTVDESMDEADPLEDVEEVKKPKEKTKKSKAVSEDEDEDGTGDETQYEVEKVLDDKMIAGVRHYLIRWKGYGQGDDTWEPEDTLNCPDAIKAFKDAKKKTKKVKKDAGEEWDENEDFEVSRILEVHHNKNGKREFLVSWKGFSPKDNSWEPEENMDCKDLIEKFMKKVDKAKDVDERELRVNRKHVQRLTYNTPDTSRRLSRRMSGKERVQYHDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTJ4</accession>
    <name>A0A6P7GTJ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114340553</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147150.1">
        <property type="nucleotide sequence ID" value="XM_028291349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTJ4"/>
    <dbReference type="FunCoup" id="A0A6P7GTJ4">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291349.1">
        <property type="protein sequence ID" value="XP_028147150.1"/>
        <property type="gene ID" value="LOC114340553"/>
    </dbReference>
    <dbReference type="GeneID" id="114340553"/>
    <dbReference type="KEGG" id="dvv:114340553"/>
    <dbReference type="CTD" id="6189"/>
    <dbReference type="InParanoid" id="A0A6P7GTJ4"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028147150.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29991" checksum="DA8291549AEC0059" modified="2020-12-02" version="1">MAVGKNKGLSKGGKKGVKKKVVDPFTRKDWYDVKAPSMFATRQVGKTLVNRTQGTKIASEGLKFRVFEVSLADLQNDNDAERSFRKFRLIAEDVQGRNVLTNFHGMDLTTDKLRSMVKKWQTLIEASADVKTSDGYLLRVFCIGFTNKDQLSQRKTCYAQHTQVRAIRKKMVDIITRDIQGSDIKEVVNKLLPDSIAKDIEKACQGIYPLHDVYIRKVKVLKKPRFELSKLLELHGDGGKGGAGDSTGEAGSKVDRPEGYEPPVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTP6</accession>
    <name>A0A6P7GTP6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">26S proteasome regulatory subunit 10B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114346627</name>
        <name evidence="14" type="synonym">LOC114345969</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152572.1">
        <property type="nucleotide sequence ID" value="XM_028296771.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153171.1">
        <property type="nucleotide sequence ID" value="XM_028297370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTP6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050661280.1">
        <property type="protein sequence ID" value="XP_050517237.1"/>
        <property type="gene ID" value="LOC126891933"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14 15" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="169"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028152572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028153171.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="44552" checksum="3B8A3FE3E2E1AF69" modified="2020-12-02" version="1">MTQMDPEREKSLQEYRKKLLEHKEVESRLKEMREQLKDLTKQYDKSENDLKALQSMGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKAKLKAGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGDVTYSAIGGLSEQIRELREVIELPLLNPELFMRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFLKVVSSAIVDKYIGESARLIREMFNYAKDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGQVKMIMATNRPDTLDPALLRPGRLDRKIEIPLPNEQARLEILKIHALPIAKHGEIDYEAIVKLSDTFNGADLRNVCTEAGLFAIRAEREYVIQEDFMKAVRKVADNKKLESKLDYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVS6</accession>
    <name>A0A6P7GVS6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MKI67 FHA domain-interacting nucleolar phosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114347327</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153846.1">
        <property type="nucleotide sequence ID" value="XM_028298045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVS6"/>
    <dbReference type="FunCoup" id="A0A6P7GVS6">
        <property type="interactions" value="1253"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651100.1">
        <property type="protein sequence ID" value="XP_050507057.1"/>
        <property type="gene ID" value="LOC126884833"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GVS6"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="54"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028153846.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40279" checksum="08081A03E668432A" modified="2020-12-02" version="1">MTKTRAAEVLSLEKSKQKEVVKETKQLKKKIKDGTVTVKGTKKALIAAQEQKRGLIFISHLPHGFYEDELKKYFTQFGKVTNVIVCRSGKTGNSKGYGYVEFVNPEVAKIAAETMNNYLMFKKRITANFVAPEKRPKGLFMGKPNTITRYSSKVRRQKQYLVNIKLDPKTQAKRTANRLTKINKKLEWLKNAGVETSFTPSNLEVKQKKSVPRVSNTHKELDFDSDIELKIPVKKAKSAVTSSKNSPKVLSTKASKSNKKLNKSVSSESEKTPSIKKKLNKASKTNIVEDTSPSDKKSLKKKNKSSKGITKKSKKPEPINTQTVKRIARELIKKRGSSLLGVPVEVSNGKTIKKKLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H016</accession>
    <name>A0A6P7H016_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth hormone-regulated TBC protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114342780</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149375.1">
        <property type="nucleotide sequence ID" value="XM_028293574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H016"/>
    <dbReference type="FunCoup" id="A0A6P7H016">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657374.1">
        <property type="protein sequence ID" value="XP_050513331.1"/>
        <property type="gene ID" value="LOC126889261"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H016"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000029">
        <property type="entry name" value="Growth hormone-regulated TBC protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF10">
        <property type="entry name" value="GROWTH HORMONE-REGULATED TBC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="64"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028149375.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37824" checksum="774BAAB926992822" modified="2020-12-02" version="1">MAKSTFSKVDEYGFERPDNFNYEVYDNFMSGYIRVLTRRAQRWSTVKGDVYRKPNVLKRFIRKGVPSNQRTAVWMRVSGAENLRNSTNLSYGALKKNIDNQHIIDTIQIDLPRTFPENIYFSNHEYLPKELFNVLATFAHQNKEVGYCQGLNYIAGLLLLATKDEEASFWLLKALVENILPQYYIVTMTGLLTDLDVLDELVLKYEPLVHRHIRNVGMPWAMGTTKWFICLYSEVLPAETVFRIWDCLFNEGSKILFRVALALIRLHKDQILQTSELGELIGCFRDMRNHETVINCHLFMQEVFRLSGNLSNATISRLRQKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1V1</accession>
    <name>A0A6P7H1V1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114349353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114349353</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155504.1">
        <property type="nucleotide sequence ID" value="XM_028299703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503759.1">
        <property type="nucleotide sequence ID" value="XM_050647802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1V1"/>
    <dbReference type="FunCoup" id="A0A6P7H1V1">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647802.1">
        <property type="protein sequence ID" value="XP_050503759.1"/>
        <property type="gene ID" value="LOC114349353"/>
    </dbReference>
    <dbReference type="GeneID" id="114349353"/>
    <dbReference type="KEGG" id="dvv:114349353"/>
    <dbReference type="InParanoid" id="A0A6P7H1V1"/>
    <dbReference type="OrthoDB" id="5814089at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052296">
        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
        <property type="entry name" value="AGAP007109-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028155504.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38962" checksum="B285616AB6475297" modified="2020-12-02" version="1">MEVSTKLQLKSELHSEEQTQITSKPVKRPFDVAFLMLPDEKLKQKQQLDRSYDNCCSSNEEDEEIDVMETPREYKKMYTQKQQIFDDPNLVKAKHIDDLRAKILPTHSEQKSAFTKVNLGKESRLSPSLSISPDLNYQSSLSPSPPIISKSYQNFPTILSPNQIFKNQQIAYQNQFLQENFSHSSSNNLENNFFKAQPELIQPNFAKIRPIYRPDLAYNYQQFTNPEMLKMAPPDLRNPAAAILTSLLPPSLAALSLPAQNICAKCNISFRMTSDLVYHMRSHHKSEAVESTRKKREDKLKCPVCAESFRERHHLTRHMTAHQDKDEDEKDASSKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H270</accession>
    <name>A0A6P7H270_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neuroguidin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114343533</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150175.1">
        <property type="nucleotide sequence ID" value="XM_028294374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H270"/>
    <dbReference type="FunCoup" id="A0A6P7H270">
        <property type="interactions" value="2330"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641830.1">
        <property type="protein sequence ID" value="XP_050497787.1"/>
        <property type="gene ID" value="LOC126878965"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H270"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028150175.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="33973" checksum="4FE5731D306212C8" modified="2020-12-02" version="1">MVQTSGVNMKYRDLPQVLILLNEMNVSAQHVAALVDSMIQKVRKGELTTDQGLSFLEMKYNMLLTYLINLTYVVLRKCCGEKIEGDPCIDRLIEIRTVLEKIKPIDQRLKYQIDKLVKTATTGKTADDPTHYKANPDNLLGNSDDSESVVSEVEKESRDRKSVYVPPKLTALYYTGDETSQQRAKTLQERSKKNVISSAIMQDLREEYLDTPLEVSQSSRAQQVLSKQQQERQEYEEKYMTRLSVSKSEKHKKHQLTTLGTLGDEITNFGRSQRNKRKKKFSSNKKGNLKKRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IA56</accession>
    <name>A0ABM5IA56_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128377.2">
        <property type="nucleotide sequence ID" value="XM_028272576.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272576.2">
        <property type="protein sequence ID" value="XP_028128377.2"/>
        <property type="gene ID" value="LOC114324745"/>
    </dbReference>
    <dbReference type="GeneID" id="114324745"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF39">
        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128377.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="379" mass="42471" checksum="3C9E34FC77325A80" modified="2025-10-08" version="1">MRISESILPIILSLFIGTLSDRLGRKPFLVIGITGITIHTILNTFVAYYDNLSPWYFIVTSLPGTLVGGFSTTFLIIALYLADTTTPKKRAMRMGFFEVGMASSFIIGSLCSSYLFYATSYVTIYTISTSLMCVSLLYIIFLVPESLKVEKKMPSLRELMSDINIKEILRVPFKKREGNTRYYILTLMGILVVYSFVIGGDVSLRTHFLRQKVHWTLSQITNASVYSRVLLILGTIFGTTILYKKLKMKELQLVILSLVLYIITCILYGLATSDIYIYAAFTCRCFGGLIQSMVRTLISFMVPSHELGKLYATSSAIDSVAQLVSSSVYPQIYNATINTNSGLFYFVNVGIYGILVLVILNLMRFEMPKAIESDSHVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEJ8</accession>
    <name>A0ABM5IEJ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131111.2">
        <property type="nucleotide sequence ID" value="XM_028275310.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507440.1">
        <property type="nucleotide sequence ID" value="XM_050651483.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275310.2">
        <property type="protein sequence ID" value="XP_028131111.2"/>
        <property type="gene ID" value="LOC114326854"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651483.1">
        <property type="protein sequence ID" value="XP_050507440.1"/>
        <property type="gene ID" value="LOC114326854"/>
    </dbReference>
    <dbReference type="GeneID" id="114326854"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22042">
        <property type="entry name" value="HMG-box_EGL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="526"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="526"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131111.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="708" mass="78856" checksum="A259659C8F0D2500" modified="2025-10-08" version="1">MSSKRKSPPTKLHEGTNSTDPTTPGIQHTGSGSEGGGLTDLDETSSNNLSDICEEDNNTMVHNSNAFYKLSEPSSPGSVSPSEGEDLEEDRMPPNKSARMGEPHIFVSSSIQALSLHTDHERRRNSSECSSPSADIKTNSYNNNNNNNSLVNNNSSSHPLKRTMDDVLKRLTSKINHSTIREEKRPTPCSTPNSVNNSDVEPTAAIQQALSGDNIMEKDRKLSELIFQLQMVREQLLQQQPEPNKTPSASQLVNDTHQKQLELQRLQQEQLLQHQQKLQELQGQITAQYAAGPHQAGLMFLPFLEQLRGLQPPAMPPNVAKSPMGNHMLPPHQVPNWISATAHLAQMPNMTGPAPEKRSPPPQTTPSTPPPPPSDPDAPLNLSKPKSSSSGSARSSPQSTPTAPLQDQPVAATAPKLLPPNLMMSRAFLPYAGLPPQFPLDRNMPNKDMTSPDKQPHFPLHMYGLPTPPHMGGPKEDSIKEDRDFLASCHLWGSPDANFKLEADNAEKAKIIRQQAKRDNENKPHIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGARWKAMSNSEKQPYYEEQSRLSKLHMEKHPDYRYRPRPKRTCIVDGKKMRISEYKMLMRQRRQEMRQLWCRDSTDMNNFMPPNPDMSPATSTSGRPSVSPPMGILNGAGPSSDASYYYTQDSTSPEAMNFSQDSSMAYDSSPRHGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJ37</accession>
    <name>A0ABM5IJ37_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ESF1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133942.2">
        <property type="nucleotide sequence ID" value="XM_028278141.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278141.2">
        <property type="protein sequence ID" value="XP_028133942.2"/>
        <property type="gene ID" value="LOC114329121"/>
    </dbReference>
    <dbReference type="GeneID" id="114329121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="172"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133942.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="76290" checksum="D96E2FDA8FC67D85" modified="2025-10-08" version="1">MEDSRFAHIKTDPKFRRIPKKERKVKIDKRFQSMFKDKQFKVKYTIDKRGRPVNHTSNEDLKRYYELSSESESSVSESESDEPAEVGRYVKRPTDEEDTELKVKDKSDKTLTDDVKKKLRNLSVDYARGESNLLSESSSDDEESDEEVSEAEEIDHKWGELDADAESTDEPTTRLAACNMDWDRMRAIDLMVLFNSFLPPGGVIKSVGIYPSEFGKARMKEEEIKGPTELVQAKVDDEVEDDQEEGSSYHMEKLRQYQLNRLKYYYAIISFDNTVSANKIYTECDGMEYESSAIKMDLRFVPENMEFDDEPKEYCDKLPEVNKYQPRFFTTTALQQAKVDLTWDETDPNRIEVTEKLSSGKLDDLSQKDLQNYLASSSGEEDSDVQEKEESEDEEESKENVIDKYKALLLDIENKDTSKNNKDLEMEISWGINLKEKTDKLAKDKSSEDKTPFQQYLDKKKEKRKEKKKKKKEQKQDDEDSDMPSDIDVNDPYFAEEFNNPEFKKPKKQKKKVSNSDDEDDQKQSELELLLMNEDNKNHFSLKKIQESENDTKSKKKRKNKNKDDGKPGEDFEVNVKDERFSALFTSHHYNIDPTDPHFKKTKGMETLVNEKLKRRAEKGQEEVTVKKPKYKNAELSSLVKSVKRKTTEYMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQA3</accession>
    <name>A0ABM5IQA3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138696.2">
        <property type="nucleotide sequence ID" value="XM_028282895.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282895.2">
        <property type="protein sequence ID" value="XP_028138696.2"/>
        <property type="gene ID" value="LOC114333069"/>
    </dbReference>
    <dbReference type="GeneID" id="114333069"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138696.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13912" checksum="40E145768205B7EC" modified="2025-10-08" version="1">MGVVTKAHIHEYNMFKNKDLSDWIALIKVKKLNFKCQRRKNLFIEAVLNKALTSAESELRQKQQERRQRWQNLKSELGLNRNESCDRPWPTQSCDELEKDIDSFLSKLKVVNSHIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IT10</accession>
    <name>A0ABM5IT10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028141026.2">
        <property type="nucleotide sequence ID" value="XM_028285225.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285225.2">
        <property type="protein sequence ID" value="XP_028141026.2"/>
        <property type="gene ID" value="LOC114335068"/>
    </dbReference>
    <dbReference type="GeneID" id="114335068"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="120"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141026.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="674" mass="73605" checksum="12C7FA1DA778F98C" modified="2025-10-08" version="1">MHSNDKDNFTDNPQQQYATRNDEAYDNPSFTHSSADISSIHSQRSTPCLGSAYLGPNYLGSNQFIVLDEDNRNTSVSSVIKNIVPWTKNRIRKGFTKKMLYRKLPILDWLPKYNTSYAAGDFIAGITVGLTLIPQGLAYHSIIGLPPQYGLYSSFIGCFIYIIFGSCKDVPFGPSALNAILAAQAVKGRGPEHAILLSFMAGLIQILMGIFGLGFIINFVSGPVSSGFTSAVALIIITSQVKDILGINPKSGTFVESWYNILQELPNTRLWDTVMGITCIILLLLMKSIGTKKLGSDEQKPAAFQKLFNNITWIIGTGRNAILVIICAFIGYVYCSIGEPPFLVIGEVPQGLPRFQPPSFGYTKEVNGTVVQEYTFMEMLSNLGSGIIIVPLVGLLENIAICKAFANGKPVDATQELIALGFCNIGNSFVQGYPGTGALGRSAVNNASGVRTPLGGLYTGILVIVALLFCTEYFYYIPNAVLGAVIIAATIFMIEVKVVKPMWRSKKSCFIIFIVTFIACLVLHLEIGILVGIGINLLLILYHAARPKIFVEKLSTTGGVEYLLLTPDRCLIFPSADYVRHIVTKYGVRQGIPVVIDCSHIYGADFTAATVIETLTSDFAARDQIIFFFNLKPSVCSVFEGLSPKGFVVFYNGNELDDLLLKYVKGENIKGENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IVL2</accession>
    <name>A0ABM5IVL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cathepsin propeptide inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143889.2">
        <property type="nucleotide sequence ID" value="XM_028288088.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288088.2">
        <property type="protein sequence ID" value="XP_028143889.2"/>
        <property type="gene ID" value="LOC114337599"/>
    </dbReference>
    <dbReference type="GeneID" id="114337599"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
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    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143889.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19683" checksum="57240BD8833145EC" modified="2025-10-08" version="1">MKSVIVLTALYIGVINCYSDYSLWTDFKAKHLKTYCLHEEQTRFSVFQQNLRKIEQHNARYIKGEASYFLTITKFADWTKEEVQKFLRPLPENKLALRSVDQNPVRADYPDSFDCRDHGAVIEIQDQGQCLSGWAFAAAGAVEGRYAALEKKLIALSAEELIDCSTYENTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZ92</accession>
    <name>A0ABM5IZ92_DIAVI</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028151564.2">
        <property type="nucleotide sequence ID" value="XM_028295763.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295763.2">
        <property type="protein sequence ID" value="XP_028151564.2"/>
        <property type="gene ID" value="LOC114344939"/>
    </dbReference>
    <dbReference type="GeneID" id="114344939"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151564.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="507" mass="56441" checksum="4E3A2237C660128E" modified="2025-10-08" version="1">MNIVNKNEGNERKLSKNEGVLEGELLEVMYVGLETEDEHELKPENGSSQTNTLFLYLTVLVIQMPILISGSQIVWNSPSIPKITSNDSQINPLDHPATTIDISMIAGIPGLAGLIGTLALPKFSNILGRKLILQVMVFFTLLGSLLLTFSRSVTVIIVSRCIISIFLQGAVAIVPIYITEICEDHNRAKFGCFLGLFHQIGHFYTFVVGPLFSYKMFNFFISLPAIPFLALFIFFPESPAYLLSKGKRTRCVKALKKLRRNKTDKEIEEDIRKLEETVKSKERTKQNSSILSLFQTKESRTGLMLAMLPLMVNHLSGVAVIMSFLAPFFNSAGTGISGHKVGVMASTAKIVCFGITSSVVERVGRRRMLFLSSLATGVPLFGLGCYFYLKHINSPIIHELQWLPLILVLSDVTFYSLGLGPIPISVMHEMFTAEHRAAAGSFLMSVMVIVMFLLTSSFPIIAATIGTHWAVWLFSFSCFLGSFFIYRYLPETSGKSLLQIQEMLKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0C6</accession>
    <name>A0ABM5J0C6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the unc-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155559.2">
        <property type="nucleotide sequence ID" value="XM_028299758.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299758.2">
        <property type="protein sequence ID" value="XP_028155559.2"/>
        <property type="gene ID" value="LOC114349398"/>
    </dbReference>
    <dbReference type="GeneID" id="114349398"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08781">
        <property type="entry name" value="Death_UNC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="16">
        <location>
            <begin position="578"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="14">
        <location>
            <begin position="951"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155559.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113730" checksum="B21DCE3D59ABDE0C" modified="2025-10-08" version="1">MHPLEPNCQPSGESYPRSSQMVTMQHPLASIVTVTLMFGIFLQLGVKCNQDGALLEEQSTPKPTPEQDESLLLNTDLPIFLAEPQNAFVVKNRPATLQCRAAHALSLYFKCNGAKKVETVENWFVDPQTGVRIFEADANVTRDMVEEFFGKEKFKCECYAWSGRGSIKSQPATVEVAYLKKQFEANPESTYNVEIGHQVDLKCVAPAGMPPPRVYWLRGGQILQSDTDVLVTSEGHLLIGQARPQDTGNYTCVAENIAAKRMAPTSQIVVYVNGGWSPWSSWQDCRCPGATLAAGKMSTRTCTNPAPSNGGKNCQGSAIRRTKDCIPCPQEELVLDNAYDYDTSDNAYVEPARWSSWSEWSDCNEDCTKIRKRQCIPGSEGGRKNCPGKDTQSLKCSTEQCRSVDLTKVRDANMQNTQNDILLYIGLTVAIFLVCLLSFFVIKIYRKKGQHQSLYNMASNDYHPEFFPDPDKKSLTLQPDVTQTVPPCYEYPYTTPATSVTRSVSEHHYDVPHLTSGSDIQMSPATSSTLESSSGKRSQLSGFTNNSDSTYEVATDTVTLPIATLPTAYAVTPTTSGNYTSSTLSSTGGFLNLAESAVSLLIPDGALSRTRKQELFLSILNEDCFRPKLAEGLTQLSPVVSCGPNISLNKAVVLKVPHCAEITRNNWQISILQSDCSDSQWQNAVTLGQETINTTVFCQLDKSAAYLVTESLARYVIVGRSASGAALKRLKLAVFAPKLCFQSSGDYSIRVYVLEDTDSSMETVFGQEKRLGGYLLDEPRSIMFQDGGSNLCLSLDDISDGWRAKPSTNYQEIPFKHLWQANSNSLHCSFTLESFELSRFLNFKLRVNQKGFDYIQVFDINCRDDGAETSTEKTSSGKFNHNEFVPKMCETTKSTESRKGVEYAKSAKRLDTKNMIVTDRGVSTCDDFNFRLTKPLRKQLSQCLDPPIQRGNDWRMLAHALKVDRYINFFAIKPSPTDCILDLWEARNRGNNALTELKQIFNEMERFDAVNILDNSLGPNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHY2</accession>
    <name>A0ABM5JHY2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497547.1">
        <property type="nucleotide sequence ID" value="XM_050641590.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641590.1">
        <property type="protein sequence ID" value="XP_050497547.1"/>
        <property type="gene ID" value="LOC114326365"/>
    </dbReference>
    <dbReference type="GeneID" id="114326365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19601">
        <property type="entry name" value="serpin42Da-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="72"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="448" mass="50291" checksum="CD7F357599CC56D6" modified="2025-10-08" version="1">MGLVKVEDFGSRIDRLSVSARNFIHLVSNSVYGSQLFLVFVTFFLLSTSTFVMAEENKHLTAVLQGNGLFTRNAYQILAQEKGKNIFFSPISIHAILSLASQGSGGKTQKALTSALQVADIATLAEGYKAAMLKLNSVEDVTLLMANKVYVKNEYALKDEFKDKVVNHFFSEVQNVDFSQSAAAAKTINTWVEEKTKDKIKDLIQPDDLNDDTRLVLVNAIYFKGKWAAPFKPEDTKTEKFYLNDNDSIDVQMMHTKKKFFFKNDEALDAKVLELPYTNKDLSMIVILPNKRNGINELELKLANTDLTKITENMFRPDVIVALPKFKIETTINLEEPLTKLGLGVIFSDHADFTGMLKSPEPLKVSKVIHKAFIEVNEEGAEAAAATVMKMKMVKKVRLPPPVQEFIADHPFLVVLILREKDENEDLTINILFKGKLSSPTYNVPNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ94</accession>
    <name>A0ABM5JJ94_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498011.1">
        <property type="nucleotide sequence ID" value="XM_050642054.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642054.1">
        <property type="protein sequence ID" value="XP_050498011.1"/>
        <property type="gene ID" value="LOC126879108"/>
    </dbReference>
    <dbReference type="GeneID" id="126879108"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF263">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1747"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="172"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="289"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="396"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="513"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="624"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="737"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="849"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1186"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1405"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="10">
        <location>
            <begin position="1525"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1888" mass="210684" checksum="F77BA0DFC457C18E" modified="2025-10-08" version="1">MEIHRLVFKNFLRTFTGHFVKIKFKIDNSSSKCSTQCNILVLVLLVISLSVAEGNKPPKFVTDGQTEIILRLKEGSETPVGTLIYQLRGYDEDGDYLKFGVSRFPGSDIIRIDNTSPSEANIYLNKELDRETQDEYSLVLTLTDGHLGYGHYVTQGLLLLVEDVNDNVPVFKSYQPTITVAEDFKPGTITTLEATDADEGAYGQVVYYLQNIDGEKDLFAVNTVGERAVLRLVGSLDYEKQTVHQLKILAVDRAKEGRVNTATAALLIKVEDVEDQPPEFVRITPFTKIEENSPIGTSVLRVVAVDGDRGVNNPIEYSLLSNSLNSVNDVFSVERDTGVVFTTSVIDREALPGGAGTYILQITAKEIGSKVDPTPTATTEVTVMVTDVNDETPTFKSNYYECEIAENAQINTPVTFLGNALPEVYDYDQGINGSFFLYVKGGGDAFDITPSKAVNEASFMIRVKNSTTLDFERMKRINLTLVAKEIVKSKPKFSEASVMVNLLDRNDNFPEFSKSLYEVSVPENCDIGTTVAWVQALDDDSGKFGTRGIRYTNLAGSIDYMLNLHPTSGVITVKIAGGPNWDREQISRHFLTVEARDDLGYGNRNSVQLVINIEDINDNAPMFLQSKYEARLFENKLDFEQPLKVEARDADLNGTKNSEIEYELLGDLAENFTIDSTGLISVKNPIDFESLQNSFSSSVYSVFLTVRARDWGTPSLFSDVPLLIYVEDVNDNTPVFENTFYNKSVAESSPSGTSLLQVKAYDFDGSFPNNQIVYRIQHGAADKFTIETETGIVRVARGASLDPDLTQPRKMVYPLKVLAIDGAPGDAQLQALAEVVINIIDVNNKAPVFDDPGNIAVFENTPVGKIIANLSANDPDSTATLVYKIDDSACQAMNERRVLLKTQEYDCSGAFHLEPRTGVLSIAKTLDREIVEQFQLGLTVEDINSETGPQVAHAKIVIDILDVNDNSPKFRKSLYKFSIAENSKHGTAIGSVTADDIDKNKTITYSLEGPVELTSLVHLNPDDGNIVVANKIDHEIHQWMNLTVKATDSGYPPRSSRVEVFIQILDENDNNPSFLPEPSALIIPEDIHVGTEIARVKAADADSGEYGKITYLLDRLSSQGKFTLDGDTGILKVSDKLDREEKPNFLLIIEGWDNYQYGFNSGESRNAFKHINITIEDVNDNVPVLHVPPYCINITEFHEPGQPVTTIHASDADDPETSNGQVIIDIADGNQHNLFELQPINEWSVDIRTTTSLRGRHGNYTLVMRAQDLGIPSLLVEDTLRICVADYNDHPPIFISPPPNSTLKVPENATVGSALIQILASDEDVGQNGAVRYRLKTDPAGHWKFFELQPISGILELRLPLDRKKQKIYDIRIEAYDLGVPTPLSSELDLTVYVSDMNNYQPQFMVDEYYVNFTENVGPEMEIKKLPDTIDRDEFEYEGPSGPVCYYIIGGNENNLFHVNPIDHTLMITAPLDREYQDVYILLIKATEDCTRTPKNQSFFDSDDDTQLKVIVRVLDVNDNAPKFIHRVFTGGVSTATSFGTKFMYVLAEDLDEGKNALITYYLVGKTQMTLTEGLDNLERPPFLVEKETGAVQLNFDPQRGMKGYFDFMVLANDTGGLIDTARVFIYLLREDQRVRFVLRQHPPELRNRIEMFREMLGNVTGAIVNVDEFRVHANQDGTIDKTRTDLYLHLVDKKDNSILEVDEVLKLVDQNTEKLDHLFKDFNVLDTQPGGTLALKSQLQSAGTTFWLSVSCLFLVLLLMLCLALCINQRQMYHRKLKAATATAYVSADNDIDGRGLGGILSGRVPNTNKHSLEGSNPIWLKAYENEWFKNMDDISQSEHDSLDENVISYEDSLPTTDQTQETQERTQNIYQTLPVPAVRKLETTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJZ1</accession>
    <name>A0ABM5JJZ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498258.1">
        <property type="nucleotide sequence ID" value="XM_050642301.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642301.1">
        <property type="protein sequence ID" value="XP_050498258.1"/>
        <property type="gene ID" value="LOC126879245"/>
    </dbReference>
    <dbReference type="GeneID" id="126879245"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="634" mass="72549" checksum="A443DF211CF91E78" modified="2025-10-08" version="1">MAPKRSEIWFHFEILKDKCNAKCLYCKQILSTKNGSMGNLNRHMKTKHPTISIARKGVTSIVSLEEIQETSDRDFNLPSTSTGADAISGVTSEDENIQHKLKKQKTQSVLTNFTYSKKPLSIARCKEIDLQILRFIVKGYHSFRIVEEVEFKKLFEMLSPNYNVPSRKTLSNNLLEQLHQSNQEKIEIELSQVEYICITTDSWTSINNESFVAITAHYIIEEQSQLKLRSHLLDCFAYEERHTAQNLAKLLADKFKEWKIESKIVCVVTDNAANVLAAVREGGWNSRGCFAHLINLLVRHGLKTIDPTLDKLKSIVAFFKKSSSALTKLTKTQVQMGLPELKIKQDVRTRWNSTLDMVNRACKIKDAIISTLALECPNLNNVTGHEWSVLEQLIEVLHIFKEITDEISAEKNVTSSKILIFVRAIYEHLKSLKNNFNLEEELKQVVADMLNQFFERFGDIENNAILAESTILDPRFKKFGFKEESKYTTAVGNLRRKISAIYNKNKTILQEISEADYNVPSSSAIKKPTLWSHFDQDVGNLLQEKNSTAAAIVELDRYLSEPLISRNEDPLAWWMTRKHVYPTLFNYVKKRLCIQATSVPCERIFSKAGLTLTQKRSALKSSRVSKILFLNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK03</accession>
    <name>A0ABM5JK03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498271.1">
        <property type="nucleotide sequence ID" value="XM_050642314.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642314.1">
        <property type="protein sequence ID" value="XP_050498271.1"/>
        <property type="gene ID" value="LOC126879251"/>
    </dbReference>
    <dbReference type="GeneID" id="126879251"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="465" mass="54365" checksum="1F2B645D9DC97FC7" modified="2025-10-08" version="1">MEINDDDSYKNELSNIKCKIEIKTDDENYEDTPVWIKNEFKQEVLSELDHKVDDSTDKVDNIVDSKIWFDQISTTALVADVKTEEIQEPKVICNELDLNEEHQTSQHGVLQSVVKTKSGKSLATDTRENSYKCETCLKEFSQEGRLKNHLRIHTGEKPFKCDICCKQFSQNGNLKRHMMRHTGEKSYKCEICFKQFCEVSSLKTHLRVHTGEKPYKCEICSKQFSQVGNLKKHMIRHTGENPNKCKICFKQFSEAAKLKRHMIRHNGEKPYKCEICFKQFGAAGNFERHMIIHTGEKPHQCEICFKQFSEAGNLRRHIKRHTGDKAYTCEICLKQFIEASKLKNHLIIHTGESHYKCEICYKTFTQPTSLKIHLRIHTGEKPYKCDICSKQFTATSDLKRHLRVHTGEKPYSCEVCFREFSIARNLKRHLIIHTGEKPYKCDICSKQFSREEHFKIHLRVHIGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKC9</accession>
    <name>A0ABM5JKC9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 53</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498398.1">
        <property type="nucleotide sequence ID" value="XM_050642441.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642441.1">
        <property type="protein sequence ID" value="XP_050498398.1"/>
        <property type="gene ID" value="LOC126879428"/>
    </dbReference>
    <dbReference type="GeneID" id="126879428"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043596">
        <property type="entry name" value="CFAP53/TCHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31183">
        <property type="entry name" value="TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="8">
        <location>
            <begin position="179"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="208"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="517" mass="62819" checksum="BB09606B57647CC5" modified="2025-10-08" version="1">MYKDILYPSATVPGSYQHVGKSPGSNHLFRAFEARRKRDEEEKLREEAGSKLYQKNYMFMMYDTHVEKKRIQRKIQEKVEQKVQAYEESVNKRREKLQKMLCAEERQFYHETVEMAQRGDEMRMENMKRTVEQLRARREEERLKLVKQKRIEQYINRCQELKPTLIKKHLIESKQVQLQQMRENEARREANRELDRMWNELNTKEMLMKKEREERELLAAKARQLNQNDILDKQIRGKQLLKDKEKKVMMEDKIELERVNEEMRLEKIKTLKAKRKDVESLREILLDQIRTNAEIMEKRKRDEDAIDQAYIKLSKLELEREQAEIEESITQARKETAMYKEHLKELEIKMKQEEDELGRLLEEYRQAIQRKQDEAKCKIAEAKKALQCAVLKGRDEQLEHKRKEAENQLKLKQAENEMIRFIFERNACLQAESDRLEREAVKQYRDDLKKQIDYNNMLREKERQELERQLEKGKEEEERYQKLVQELIIKETETPAYKHPFKKVLEQYDCSCNFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLT5</accession>
    <name>A0ABM5JLT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498902.1">
        <property type="nucleotide sequence ID" value="XM_050642945.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642945.1">
        <property type="protein sequence ID" value="XP_050498902.1"/>
        <property type="gene ID" value="LOC126879730"/>
    </dbReference>
    <dbReference type="GeneID" id="126879730"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="137" mass="15365" checksum="38D185FCA82DAA48" modified="2025-10-08" version="1">MVSTFYWFKKPIKVPQAADQGFGPEICTAVFVRPDIDVASTSLTDQNDIKILTVEMNSCTVTSIYKPPNADFAFEEPSNFQSQQIKFVLGDFNCHSVAWGYNETAFNGEELEKWAESMNLKLIHDPKQPASFNSGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMY4</accession>
    <name>A0ABM5JMY4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499301.1">
        <property type="nucleotide sequence ID" value="XM_050643344.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643344.1">
        <property type="protein sequence ID" value="XP_050499301.1"/>
        <property type="gene ID" value="LOC114324645"/>
    </dbReference>
    <dbReference type="GeneID" id="114324645"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="569" mass="63396" checksum="C13F3CB44AC4BC6F" modified="2025-10-08" version="1">MKLSNPLWCLDSDVCIYIIFYDAVPIVIAMGTPGDKAGSIKEVIKTESEEPAPRPPDPQQQLQLFSPPPSSPSSTPASFPLQQTISSPGPGPPSSSDMGVINILPHFRTLASPPQHVGTKPEALIKAELEQSTIERFYGQTKYYPDYQQPSTSYSTTSKSKTFLSSSEQPGPSGLQTPKSKPSASSASPGRLKRLRKTAQEQQGTPQSRKSYQCPYTYCNKIFSSSEKLEKHEQTHTGSSPYKCEHCKKVFSSKFKLVRHALIHSDRKPFSCTVCDRTFHRKDHLKNHIKVHSPQKDIHVCDSCKKQYTSLLSYRKHLALHAAEEGNLTCQICNDTFDSKEKILYHLKIHAGSRTVKNPNDKKFKCDQCDSKFFTRKDVRRHSVVHTGKRDFLCQYCPQRFGRKDHLVRHIKKSHNDKYKAEETITSITIKTEPKEMLLASDVSVKSEYSESSLSNAPETFGTVTVDSSLPLIEGDLTPFLEIETGHLLPVEPELKDFGSAILEDIESTPSTSGILTTENLDASQDVLDEVVLNNPELLLLESDGDTNLPLPGFSQTFQPPPAPGPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPM1</accession>
    <name>A0ABM5JPM1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499887.1">
        <property type="nucleotide sequence ID" value="XM_050643930.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643930.1">
        <property type="protein sequence ID" value="XP_050499887.1"/>
        <property type="gene ID" value="LOC126880171"/>
    </dbReference>
    <dbReference type="GeneID" id="126880171"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="765" mass="88289" checksum="C5B719EA525ABA92" modified="2025-10-08" version="1">MSTLRNNIYLVGVMKNQICGSKLPCKRDVLSVLFYNMRVVNLNLNDSSALVIDEVVVFWKKARIPVQNCSNCILKLKSLYDNVRNLEKSKNRDTERQREKENDFKEALDNLFDIATLNALNEIKIAEDREFLIKQREKGRVGCMLGVDIKLLRKEKRKEERTAAELKRKEDLLENSSCSIGHFEMEDKEHEDSQKKVINQDNSEDDIYFISESQQGPSSNKRGRKTLMTPRLAAALDKCKVSDRDAMHIISAVLEALNIDITEFVLNRSSIKRNREILRKIKYSSIKSVGNDANFIEVHWDSKLLPDITKNEKIDRLPVIAVGLDFEQLLGVPGIASSAGSEVCSAVFHITDEWNLTEKIQAFCFDTTASNTGRIKGAAVLLQQRLGRDILWLPCRHHIFEVVLAGVFTRTKAIVTSGPEIAQFKALKENWKNIDKMKFLDYTSDEAVYNALKDVAPEIIYFVKQKLAEEQPRDDYKEFLQLTLIFLGDKTNVSFRAPGAYHLARWMAKAIYCLKLFLFRDQMKMRKDNSKLNAEICVFVVYCYVEAWFSATNTTGAPLNDIYFLRKLVIFKNINENIATIAITKFLNHLWYLSEECAAMAIFDDRIERVEKIRMAQKIMECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR07</accession>
    <name>A0ABM5JR07_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500373.1">
        <property type="nucleotide sequence ID" value="XM_050644416.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644416.1">
        <property type="protein sequence ID" value="XP_050500373.1"/>
        <property type="gene ID" value="LOC126880518"/>
    </dbReference>
    <dbReference type="GeneID" id="126880518"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045665711" evidence="2">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="192" mass="21718" checksum="EE5266D7E97DDC2E" modified="2025-10-08" version="1">MASQFSIAILTCSLLAIIAEGLELFSKTERSLNLQKLENCRGTHYPMQWNNAKVTFDKASKQKVLSVTLLVKEEISTGFWMTFSFLKCDTSGNPDSCEYMLKDQKIENICKYLGMKDQSWSEFLGCFDKQFVCPMKPDTYKCSNLSVNARSLKRLPIKDAVWKLHIGGHDKGKKISCADVEIKVVTPLGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRG6</accession>
    <name>A0ABM5JRG6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500533.1">
        <property type="nucleotide sequence ID" value="XM_050644576.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644576.1">
        <property type="protein sequence ID" value="XP_050500533.1"/>
        <property type="gene ID" value="LOC126880599"/>
    </dbReference>
    <dbReference type="GeneID" id="126880599"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="385" mass="45666" checksum="856C1AC02A4DF5C7" modified="2025-10-08" version="1">MMLTKFLYAKPVVKGFLEKNKMQIIKTMPEFTRSKERCLSQPTENLLCPTCNKQFSRKDSLKKHLKGHIKPFSCHICFKSFSFNYSLKIHMRVHTGEKPYQCEICFKSFAQHNSINKHRRLHTGEKTHQCEICDKSFSELYSLKDHMRVHTGEKPHQCKMCLKSFSAKYNLKLHSRTHIEEKHNEEKPFKCGICYKSFSRQEYVKKHMRSHTGVRPYQCEICSKSFAQSNCLKKHTRVHTGEKPYHCEICLKRFSLNSTLKLHTRTHSKEAPYQCEICFKSFSQPDSLTEHTRVHTGEKPFHCEICLKKFSLKRTLKSHIRTHTRETPYQCDICFKSFSTLNNLKEHTRVHTGEKPYQCEICLKRFSIKRTLKRHTRTHTTETSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRX3</accession>
    <name>A0ABM5JRX3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500680.1">
        <property type="nucleotide sequence ID" value="XM_050644723.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644723.1">
        <property type="protein sequence ID" value="XP_050500680.1"/>
        <property type="gene ID" value="LOC114335505"/>
    </dbReference>
    <dbReference type="GeneID" id="114335505"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF0">
        <property type="entry name" value="STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="278" mass="30579" checksum="0BFE8B2E5B4324F6" modified="2025-10-08" version="1">MVRGLSLGTGLVIFVSSLSETLLEISQYHKEPPSGPVYGYRYGWCFFTAGVAFIMTNMAAVFSISGYLNRFSTVDEMVRQMVPGAERKLLEHHQMSSDYLQPIMPTSLQYDPYETEGPNYETETGSMMTKTPPDVCSTNKCPDYILEHREQTCIIPNVAEPTLSVAQTLAGQTVPITIKSHNSTAPLSFSNLPMKYGTLHFDHSASNTLHQGFLGVSDLGSSSSTSSSGYCGRSKTLQHAKNRKKCATKIETFHVPETNFSDFGKRTTTDFSFSGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS73</accession>
    <name>A0ABM5JS73_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500792.1">
        <property type="nucleotide sequence ID" value="XM_050644835.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644835.1">
        <property type="protein sequence ID" value="XP_050500792.1"/>
        <property type="gene ID" value="LOC126880780"/>
    </dbReference>
    <dbReference type="GeneID" id="126880780"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="485" mass="58434" checksum="BB93A24BFA2EE6EF" modified="2025-10-08" version="1">MATLGSIRNIDYKITHAKLRVVKILHYICFSTEGEPRKTRKALRAFAGFRLDDTSEQFLSKCNDVSEKFDLPDLIAICQILDLNYKNEKHDVVVRICSFLNTFINEDETEDDEEEDDVSDIGEDDERRKEEKRQLEDEKRRMQEEKRRLEDERRENDERREKEKRRLDEERRKDDERRAKGDERLEEEERRRRERRNDELRRRREGRNYDEERQICDEKRRYERSNDEERRRYEDRRYDEDIHVHEEIGERSYSASNNAEIRFANNGATGTRRQESFGLSFRDVEDSIRSFNGKDEYPIRTWIIEFEEVAEITGWNDLQKLIYAKKCLNGLAKLFVQSEKGIRSWPDLKRCLIEEFGVHVNSAQIHKMLMTRRKKSDETVQEYMIKMREIANRAYLEQEVVIEYIIDGIQDESFNKLVLYGAKDFADFKEKIKLYERIRGKETTGQAQGFRGNKEGSKKNEDIVKNEKREKNDRKRENNITCFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS88</accession>
    <name>A0ABM5JS88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500807.1">
        <property type="nucleotide sequence ID" value="XM_050644850.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644850.1">
        <property type="protein sequence ID" value="XP_050500807.1"/>
        <property type="gene ID" value="LOC126880791"/>
    </dbReference>
    <dbReference type="GeneID" id="126880791"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="414" mass="47790" checksum="AF7FB8F3D35F9CF9" modified="2025-10-08" version="1">MTTVYENQEHSDSVVMPPIFDIYRKPMFDESIRKAEYRTYAPFIKSFNCNDIVEFSINQVDSFFEMSETLLCIKGSLVDKAGSGTITLANNVGAFLFDSCTYSESAREMETVRDPGIVSAVRAMTCYNQEDSKYMVMAGWNYPNNPILNDTSFNIQMPLKHIFNIFNDYPMITCGRQTIRLVRARNDNDCLIITDAATTAKINITNIELRVKHIYPNDEIKLQLMTSIQEDRPIVIPFRKWELHELPTITKGARREVWAVKTSTSVERPRYVIVFFQTGKRNTIKADPTLFDNVSIQSIRLSLNGEYFPNERMQLDFSKTDYNEAYFNYTEFHPSYAHSTQKRPLLDFTAFQHHALFVIDCSKQEESMKASTVDVKLDIEANNGFPDNTKAYCIIIHDCVMEYFPLTEIVKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTG1</accession>
    <name>A0ABM5JTG1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501229.1">
        <property type="nucleotide sequence ID" value="XM_050645272.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645272.1">
        <property type="protein sequence ID" value="XP_050501229.1"/>
        <property type="gene ID" value="LOC126881182"/>
    </dbReference>
    <dbReference type="GeneID" id="126881182"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="2">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51057" checksum="D06ED1B6B4148EA3" modified="2025-10-08" version="1">MAKIDHIRQCFNIDKRKRFQALRRIREVYLHLKTHSRLKMKVCVAARTLSHTVASTLEEMVSNPNNNIPSQAIETAEFVHDVDQLFDSFNGRTTKPECGKPYRRCMSNRSAHAVLWNRLLPKINSWMFIDEKVKKKVMPFKSGWLTTIAATKELWNICKDLGFKFLRTRALNQDPLENSFASIRHLGAENVNPSCYQFISSFKTSVLNNLITPSSNKNCETDDGSILDNLQDFLESSITKNDFIDLDVLDVNEIENLALPLPDTDVTGHEGNTLAYVAGFIIKNLKSIKECEVCAANIISDCLEPHHTFTMFKEYSDNKLSLNYVTKNFLVDLAKMYDIVIAVLVINGHINHLVKKIKILIKKYVTLEWFTCNQHLDYVFNYCLDVSVSLIIKKYYDDVYRSSQDLQKNDLRKKKINTNKKINNPSLRRNLSCRAKSDNNNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU42</accession>
    <name>A0ABM5JU42_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General odorant-binding protein 83a-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501455.1">
        <property type="nucleotide sequence ID" value="XM_050645498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501456.1">
        <property type="nucleotide sequence ID" value="XM_050645499.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645498.1">
        <property type="protein sequence ID" value="XP_050501455.1"/>
        <property type="gene ID" value="LOC126881299"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645499.1">
        <property type="protein sequence ID" value="XP_050501456.1"/>
        <property type="gene ID" value="LOC126881299"/>
    </dbReference>
    <dbReference type="GeneID" id="126881299"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028415" description="General odorant-binding protein 83a-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="17310" checksum="08E103705415BEE2" modified="2025-10-08" version="1">MKFVVSIICLGYFIVMVNCKLDRKDFGPHLHEVIDESHNRCQRMTGASEALIEEMKNGRFPEDMTIKRYTYCLWMIVMGLREDLVLDSRKMYYYIPDMHKEDAVHYMKCNEEARKLPGDDLVEKIWNMQKCVQKTIDEKHYVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUG3</accession>
    <name>A0ABM5JUG3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501578.1">
        <property type="nucleotide sequence ID" value="XM_050645621.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645621.1">
        <property type="protein sequence ID" value="XP_050501578.1"/>
        <property type="gene ID" value="LOC126881381"/>
    </dbReference>
    <dbReference type="GeneID" id="126881381"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046136238" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="81" mass="6260" checksum="06E252E0CE49EF0E" modified="2025-10-08" version="1">MRVASTIATLLCVVLLIIQTISAAPAPVPGGGGGGGGSGGGGGGGGVGGGGGGGGGKGGGGGGGGGGVCGGGGGGGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWP0</accession>
    <name>A0ABM5JWP0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502359.1">
        <property type="nucleotide sequence ID" value="XM_050646402.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646402.1">
        <property type="protein sequence ID" value="XP_050502359.1"/>
        <property type="gene ID" value="LOC126881817"/>
    </dbReference>
    <dbReference type="GeneID" id="126881817"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045667381" evidence="2">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="72" mass="7134" checksum="B9641EDC9A9983D0" modified="2025-10-08" version="1">MKFVFLFQFVLLIAVLLIQGQFTEASRDAGPHGANRGNSGGKSSGGKSSGGSNGNGGHSGGRGNGNGDRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXE9</accession>
    <name>A0ABM5JXE9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502617.1">
        <property type="nucleotide sequence ID" value="XM_050646660.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646660.1">
        <property type="protein sequence ID" value="XP_050502617.1"/>
        <property type="gene ID" value="LOC126881924"/>
    </dbReference>
    <dbReference type="GeneID" id="126881924"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="259"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="721" mass="83532" checksum="9828795BD3872568" modified="2025-10-08" version="1">MELSEHSIKRKQNVLICDKDGDSQEQNVNVQVKSELEECMFEESNDYTQDSLSESYCSDDIKIEIEEHVLQCEISGPFPLISKQEVKIELDEHNLGVNHGCETRYTQELDSKKDVKFQIGASTEIHHDHEDHCRSMKTSKLLSNIGQQKENMDYEKETKRLLKLFEEVLTDEETYEDNDDQSEIDHVEERSECSDTEQEFEDDQTEEDNVSFRREPHFMGKDKLTKWIKHCPPKNVRTRSTNIYERLPAIKQFVKTHSTPIDIWNSMFDEEMLNQVVICTNIKIETVTNDYTRQRDAKPTDIAEIKALIGLLYLAGIRKANHMNLEDLWRTDGTGIETFRLVMSKSRFQFLLQCLRFDNIHTRHERIQADKLAPIRTLLEKFNSNIKKCYSHTGYVTIDEKLEAFRGKCSFRQYIPSKPNKYGIKIFAISDAEEFYTSHLEVYVGKQPNGPFEVSTATQDVVERLCAHIYGSNRNVTVDNWFCSVPLADSLKSKKLTLVGTIRKNKKQLPLEFVQNNGRCIGSSMFCFYDGITLVSHIPKKNRNVLLISTMHYGDDIDPTTNKPEMIITYNETKSGVDVVDKLCAQYNCARSTRRWPMVPFFSVLNVAGINSFVVYTTLNEQSKTPRKEFLLQLSMSLTRDYQRVRAMSNNLPRTIRMRLREICGLPTEQVPVVTPGTSGRCAVCDWKKNRKTKFYCQICSKYLCLEHVTPLCISCFKNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K249</accession>
    <name>A0ABM5K249_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504264.1">
        <property type="nucleotide sequence ID" value="XM_050648307.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648307.1">
        <property type="protein sequence ID" value="XP_050504264.1"/>
        <property type="gene ID" value="LOC126883078"/>
    </dbReference>
    <dbReference type="GeneID" id="126883078"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF284">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="169"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="410" mass="47158" checksum="4B821974382DE751" modified="2025-10-08" version="1">MEEVLLSVLVGCLVVKKRENSRKPRSKWSRKWLLMRREFSHVKLMQELSNEPNDWRNYLKMDEGTYHELLSLVSPFITKHDTLMRKAISPHERLSATLRFLATGRTLKDIEYSTAISKPSLSSIIPETCEAIYKVLQQFIQFPKTADDWLKIASDFEEKWQFPHCLGAVDGKHIRIVPPKDSGSYYFNYKKTHSIVLMAIANAHCEFILCDVGTNGRISDGGVINNTLFYEKLINHQLNIPGPEPVSFDLDLEYVFVGDDAFALRPDLIKPYGRESLNNERRICNYRISRARRVVENSFGILASRFRIFHTAINLNVKTIESLVLACCALHNFLMKKSCNYSSPKSYDREDIIDGTKQLGARPHPDKFHNLDRSSGGQVLQQAKTVREKFCTYFNGEGSVPWQEKFALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K285</accession>
    <name>A0ABM5K285_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504301.1">
        <property type="nucleotide sequence ID" value="XM_050648344.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648344.1">
        <property type="protein sequence ID" value="XP_050504301.1"/>
        <property type="gene ID" value="LOC126883098"/>
    </dbReference>
    <dbReference type="GeneID" id="126883098"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="270"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="327" mass="36080" checksum="316B1BDB1421EA80" modified="2025-10-08" version="1">MAIDWEKIVTELSAVFQDEQETFARVLFYLGEEEKVYKDADKLGPQMKILMSSMKVASLFSQYAKRLAEDTKRADSDEKFKRVMGLIWAQMMDANKQTDDKDKTPDVSIIVKLEHLSLEALPGMVRALSIIPYESQKRFLVMVKDIVPTTVLSNVEYAVETVNKVGGPVVTVALASIQLAYEAIVNIRRWWKGEISGKRCCKNIIDSLATIGGSVGGGFAGVAVGALGGPVGMIIGGIGGGMLGGQLAKGLSQWMTEKIFDVPKSEALENAYNFFNLRNHASNHQINTAYRQKCLEYHPDKGGSEEKFHKVQMEMAVIKAAKGELYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2K1</accession>
    <name>A0ABM5K2K1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050504417.1">
        <property type="nucleotide sequence ID" value="XM_050648460.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648460.1">
        <property type="protein sequence ID" value="XP_050504417.1"/>
        <property type="gene ID" value="LOC126883204"/>
    </dbReference>
    <dbReference type="GeneID" id="126883204"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="467"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1341" mass="155594" checksum="3043510771BA79F8" modified="2025-10-08" version="1">MAVMGINVKLPPDFDLQDQNAASEWKFWKTSFEDYLLATGQDQSADKMKMSILRNIIGAESAKIMSTFEIPEAENNKYDLMISLIDKYVNPRMNESFERYNFIMRVQKEGESFEQFLTSCRHLIRTCNYNEIDPEQTAEDKALRDKILMNIRDPVTREALLRVDKLTLQKAIEFCRTSEQSKNQNLKFHTERKDVDIGEVRKDRYQGHRNYNNSRSKANTNEKFKCKRCQSTHGARECPAYGKKCKKCGLLNHFAKSCRVKNIDVIDEDSSDGSADSFVGNVNKVYQNVSSQNIWDEIIEIENKRIKVKLDTGADVSIIPLKIFKKIDKQFKIRDNHYVLKGFEGTQAKTMGVVNLFCKHKNKYVYEDFTIINGATRVLLSGKLCIDLGLVKRINNIESCGTLELAERDKFINLNPEVFRGHGKFCGKHRITTVDKFEPVSYPPVNVPVAIRDNLKNELDRLTKRGAIVKVNEIDPRASINRIVIVEKQNGKLRLCLDPLDLNKQIVRKPRVVHKLEDVCAQMIGKKIFSVFDLSEGYHHLELDETSSWKCCFATSYGIFRYKVLPYGLSNSQDLFQEVVEDKFKGIENLLICHDDMIVMGTTKEEHDTTVKKVLERAKEVGAKFNGDKFQYCQEEVRFMGQVFSHKGMQIDPDRVESLCKLEKPNSKVELQRILGAFNYVRRYIPNMAEHIQPLCQLLKNNVEWVWLPSHQKCFDNLKNIICKSPALVPYDPNQKIILQCDASKNGLGVCMFQKYDSILKLVACASRNMNDSEINYSQTEKELLAIYYATQKFHNFIYNFDVDVQSDHKPIISIMKKPISKIGSVRLQRLRLKLLKYRLNVYFVPGKDIHFADMLSRSSLNIETHDPEMFEMVHSVSKHLPMSQEKQSELRLATSQDEALAVIFDFYYNGWPKEKNVPQVCKKYYGIRDSLYFEAGIAFIDDKIIIPKKLRLDMIKLLHKGHIGVSKTINKARSIYYWPGLNDDVTNYIKKCRICEKYRPNNFKEPMMPHDIPRLRFNKVGTDILEYGSKAYLVIVDYFSHWLDISILKDKTSSSVINSFQDTFSRFGYPEILIADNLPFTSVKCKNYYREKDITIMTCTPHYHQSNGLAEKAVNISKQILRKSNEENVDFRDLVMEYNNTCIINLDASPAQILQSRILRGQLPTTANKLEPTIQKQVYKNLCKEKEKLQVRYDKTARRKPVEFRKGDRVVIRSSKDNYWRKAIVLEKANEPRSYWVKKEDNNKIIRRNSHQMKHSYTTTLEKELILEPELYPDIQSQSVHKDTTHINVNDSVNKTISCPSPNVKSVPTLSHKVNPNIETSNSYKTRVGRNIKTPYRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K391</accession>
    <name>A0ABM5K391_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504653.1">
        <property type="nucleotide sequence ID" value="XM_050648696.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648696.1">
        <property type="protein sequence ID" value="XP_050504653.1"/>
        <property type="gene ID" value="LOC126883320"/>
    </dbReference>
    <dbReference type="GeneID" id="126883320"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="384" mass="44628" checksum="7A2D311C252312A7" modified="2025-10-08" version="1">MDMKVEVNVKVEKEELDEYDQKYMDNQLSTSTDLPDIKDEPEENKPDMDMKVEDNVKVEKEELDEYDQKYMDNQLSTSTDLPDIKDEPEENKPGCSFQKENLDGYVEKKTLNKNTKVETGKSHLMTHTGKKPYKCKICFKLFTAAYSLKLHLMTHTGVKPYTCEICSKQFTQAGHLKTHLMAHTGVKPYTCEICSKQFSQDGNLKRHFMTHTGKKPYECEICLKRCITESDLTRHLRVHTGEKPHKCEICFRQFSLAYSLKIHLRTHTGENNYKCEFCLKQFSQRCNLKLHLTIHTEEKPHKCEICFKQFSQAGNLKAHLMIHSGVKPYECDICFKQFTQPSSLKTHLMTHTGVKPNKCGICSKQFRQDGNLKRHLMTHTGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9D1</accession>
    <name>A0ABM5K9D1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506798.1">
        <property type="nucleotide sequence ID" value="XM_050650841.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509593.1">
        <property type="nucleotide sequence ID" value="XM_050653636.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650841.1">
        <property type="protein sequence ID" value="XP_050506798.1"/>
        <property type="gene ID" value="LOC126884717"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653636.1">
        <property type="protein sequence ID" value="XP_050509593.1"/>
        <property type="gene ID" value="LOC126886644"/>
    </dbReference>
    <dbReference type="GeneID" id="126884717"/>
    <dbReference type="GeneID" id="126886644"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21481" checksum="B22B1A22A5618BD7" modified="2025-10-08" version="1">MEINERMGRTGSLFNTMKTTFFGKKGIPEKVKTAVVKSVVRPTIMYSSETWTLTGRQKSRVNAMEMRFLRKIANRKRTDKIRNETIRQNLKLEPINEKIVEGQLRWFGHVCRMSNERLTKRVFETRVQGKNKRGRPRVMWVDEIRKEVEKKGLTLESARNLAQDRKAWRLQCQTQLHQPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9D6</accession>
    <name>A0ABM5K9D6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506803.1">
        <property type="nucleotide sequence ID" value="XM_050650846.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650846.1">
        <property type="protein sequence ID" value="XP_050506803.1"/>
        <property type="gene ID" value="LOC126884720"/>
    </dbReference>
    <dbReference type="GeneID" id="126884720"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="331" mass="39078" checksum="9D4767358F659B95" modified="2025-10-08" version="1">MATPLSNLSYDEPIDNIFEDEDEADYQRFYMWMTKAAIFMTITDIIQFFLILGVLGINIYFIVIICRNKNLKTIKANRYLMHCSIFNLFMWITKPLYIIIMEVFRLYRYLGWGVYCVETQFETIGLTGMFLCMFGIGIEWLLAVNKTKMKPFVQKLYDHSIHIIYMLGIMKAIIDSIVCQYSFDIRYNYIEHVLLFALLAFVIYCNIKKNTLKAKNSYLLSVINLFVFSWIPLYCYDILFDVTRYQYTMAFILRVTNFIPNYLAYGSPIVIFIWLGRKNKYFKVAYRKSCSCCTCCRAISDYSGDDETFEDSEEIEDVENVENMSNNATHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9G7</accession>
    <name>A0ABM5K9G7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050506836.1">
        <property type="nucleotide sequence ID" value="XM_050650879.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650879.1">
        <property type="protein sequence ID" value="XP_050506836.1"/>
        <property type="gene ID" value="LOC126884735"/>
    </dbReference>
    <dbReference type="GeneID" id="126884735"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="41"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="250"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="551" mass="62980" checksum="27F3D6F48B7A9BF3" modified="2025-10-08" version="1">MSEDTDVKTVQFHEMELDDRLLKAIAKLGWLQPTVIQEKVIPLLLEGKDVLVRARTGSGKTAAFLLPVIQKLLNIKQTAAQQETKALILAPSRELCHQICGVIKDLTTKCSREVRYIDISLPVDLSIQKPLLVEKPDIVVGTPGRTLQHIKADNLNLKKSLELVVIDEADLVFSFGYEEEMKELITHFPKIYQAILASATLSDDVKSLKNSILHNPVSIKLEEPELAPSSQLTHYHLNAEEMDKATILYTLLKLHLIRGKTIIFVNSVDKCYKIKLFLEQFGIRTCVLNSELPATIRCHSVNQYNQGIYDIIIASDEHALEEPTIVSKKEGEKKTKRRKDKESGVSRGIDFQHVANIINFDFPLDVQAYIHRAGRTARGNNQGSVLSFVSMKESHLRDKVEKKLKQNEDDSSIFKSYQFKLEEVESFRYRAKDAWRAITRIAVREARLKEIKQEIFNCQKLKSYFEDNPTDLQVLRHDKSLHTVKIQPHLFDVPEYIVPPTLKSLANIGRKGKKRDYHKMSESSSAKFQMKKSNPLLSMQFEGFSKKKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9W6</accession>
    <name>A0ABM5K9W6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506981.1">
        <property type="nucleotide sequence ID" value="XM_050651024.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651024.1">
        <property type="protein sequence ID" value="XP_050506981.1"/>
        <property type="gene ID" value="LOC126884790"/>
    </dbReference>
    <dbReference type="GeneID" id="126884790"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="237"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="452" mass="51764" checksum="DE77940DE24C9792" modified="2025-10-08" version="1">MENIATDSGKIVKMEVDYSATCDDKIPECQKLAKSGKLHDALDQLLALEKQTRTGADMISTGRVLVAICQICKDAKNWSALNEHIVLLTKRRSQLKQAVAKMVQECCSYVDETPDKETKVKLIDTLRQVTEGKIYVEVERARLTHKLAKIREDDGDIQQAADIIQELQVETYGSMEKREKVELILEQMRLCVAKQDYIRTQIISKKINTKFFDEDGSSDLKLKYYRLMMEVDEHEGSYLATCKHYRAVLNTPSIMADAEERQAAAQAVVLYIILAQHDNEQVDLTHRVLADKVLEEIPTYKQLLKLFTTPELIKWSGLCELYEKQLKTTPVFSGNDQAQKRWSDLKSRVVEHNIRVMAKYYTRITINRISELLDLSPGETEEFLSQMVVSKTIQAKTDRPAGVVHFQQSKDPSDVLNDWAHDLTQLMQHVNKITHLINKEECVHKHLQSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCG8</accession>
    <name>A0ABM5KCG8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507888.1">
        <property type="nucleotide sequence ID" value="XM_050651931.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651931.1">
        <property type="protein sequence ID" value="XP_050507888.1"/>
        <property type="gene ID" value="LOC126885373"/>
    </dbReference>
    <dbReference type="GeneID" id="126885373"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1307" mass="151331" checksum="348181D15987EB59" modified="2025-10-08" version="1">MQCDSCLKVLSSRSSVTRHKRESCPQRFNNKVKKVKLSGVDTSANINYSATAEATSRPTAEASNTRSVKTRSNIIECQDCYKKICGRGLTGHLRSNSHKSVINYLDSGVEKLSSSFKNRISSYRLTSSKHHTDHLEFFNEIEGNVLSLLHNYLHEFKVIKVNVELYSMYTIPEKDTYDLKSFNTQNQIITISTNLKQAYQDFISEILPKVSEIQEKDSGWSLLQIQSLEVNINKYNPLRSSSYIRLPRQIEVKKAVINIMNKDEACFGWAVNASIFNPTGKSNLTTSYPHYTSLLQFHNIEFPMKLSDIPKFELLNNISINVFGVSECFKNNVTQLEIVGPLYHTKSKKSTHVNLLLIFDDNGNSHYCYIKNLSRLISSQKSHHNGQTFLCNGCLQFFSSLERLHKHEDNDCNFVYTKLPTTDMILNKFGRLQKENILQFSNFHKQMQVPFVIYADFESILQPIQHATPSDNSSFTVKTYQHTPYSFGFYIKCYFDDSLSQLIIYRGDNVAETFIQKLEKEVYTIYHKYLKHIKPMKKLTTAEELQFFESKCCHICDKPFDINEMKVRDHSHLTGLFSGAAHNACNLNYKLPKFIPVFMHNLTNYDAHLFITKLAQNNEKIYVIAQTKEKYISFTKLLLVDRGLEQNTYLKLRFVDSFRFLPHSLDNLSKTLNGDQCLELRKYCRSNEEFGLLRQKGVFPYSYLDNFSKLSEVSLPAQEQFFDVLKGEGISDEKYLRAKQVWEVFDCKNLGEYSDVYLKSDVLLLADVFENFRRNCLFNYKLDPAQYLTAPSLSWDAMLRKTNIQLELLTDIDMLHFFKKGIRGGISQCSTRFATANNQYCENYDCSKPTSYILYLDATNLYGYAMSQYLPHGDFRWLDGVEITNFDCLSIDDESPKGYVLEVDLTYPETLHDHHNDLPFCPENIIPPNGKDPKLVLTLLPKHKYIIHYRNLKQCVEQGLKVAKIYRILEFSQSPWLKPYIELNTNLRNSSDNEFDKSTYKNYTNSIYGKTMENVDKRVDIKLLSHWENLPGSIGAEGFISMPNFHSVSIFSDNLVAIQMNILKIVYDKPVYVGFSILEISKIRMYDFFYNYIKAKYMGDATLLYTDTDSLILHIQTENVYRDIKENLDLFDTSNYPVDNIFNIPKTPSVVGKLKDEFKGQPITNFCGTGAKAYCVTLSNNKHFKKAKGISKNVINKSLTFTDYKQVVDNANAKIYRKMYTFKSHLHEMYTELKNKVALTSHDDKRYVIPGAINTLAWGHYKIDAFIPDQQQNNLDYLIQQAKLLLPEQENNDGREFYVDSFEMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCN7</accession>
    <name>A0ABM5KCN7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507940.1">
        <property type="nucleotide sequence ID" value="XM_050651983.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651983.1">
        <property type="protein sequence ID" value="XP_050507940.1"/>
        <property type="gene ID" value="LOC126885415"/>
    </dbReference>
    <dbReference type="GeneID" id="126885415"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49025" checksum="7F1932A21A79D62F" modified="2025-10-08" version="1">MEEKPTEANSSQNVKGQTSKPPAKSSNRSNSHVQRSYHISNRTCASCDALNHKSYTCTKFPRLSVPERTDLVKKSNLCINCLNRGHQVNNCNFGHCKNCTVKHHSLLHVSEPSTSNTNAQQSLFTFNLSSKQVLLSTVLLEVVDSKGNRHDCRALLDPGSQSNFISSHLCHKLALPRKPTNITISGAFKVESKIEAVCQIQIVSKNTPFTAPLVCLVAPEICDVVPEAPIDPVSLSIPTCHKLADPDFHIPKQIDLLIGAALFWETLCIGQIRLKPSGPFLHKTKFGWIVSGPLSKPLLSDRSSSSPSYSQNLNIQSQLARFWEIEECSDLIQSPEEKSCEDMFTSTHYRDNEGRFVVPIPLKEPISRLGDSRSIALKRFHGLERKLQRNAQLRKLYTSFMRERGFSFAQALDIIYNDELGGDIFVEPPDTNNVDTDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDX4</accession>
    <name>A0ABM5KDX4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508402.1">
        <property type="nucleotide sequence ID" value="XM_050652445.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652445.1">
        <property type="protein sequence ID" value="XP_050508402.1"/>
        <property type="gene ID" value="LOC126885716"/>
    </dbReference>
    <dbReference type="GeneID" id="126885716"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="154"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="308" mass="35156" checksum="0084954927F291D1" modified="2025-10-08" version="1">MHQLKMATEWRKVGKVKKLCIYPFKSGKRIEVKEAECTKQGFREVEKGHRKLLLRDRSFVVYEQNYLEYRSAKHFPKLVLLEVKSHDANSIALNAPGMEPLIIPIPTGKEVHIKQLRETIPLIDCGDKASTWISTYLQGDKPGLRIGYNNGTNKRSAEVHQKQIDYCNRGMTSDSMGLSSNMCAVMLNNAASIRDFQKKSGISEINENNFRPNILVDDDNLEPFLEDQWEYLKIGDVIFKNVLECVRCLLTTVDMDKGVLRSDREPLRTLGTYRVSNGPKKDPLMGIFLEVIKTGKVSLHDDVYVGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFP7</accession>
    <name>A0ABM5KFP7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin interacting protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509019.1">
        <property type="nucleotide sequence ID" value="XM_050653062.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653062.1">
        <property type="protein sequence ID" value="XP_050509019.1"/>
        <property type="gene ID" value="LOC114325310"/>
    </dbReference>
    <dbReference type="GeneID" id="114325310"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="3">
        <location>
            <begin position="176"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="303" mass="34272" checksum="70CE9F595C6419AB" modified="2025-10-08" version="1">MLIRWKNKDKDKDKCEKTSNQKQNSSGTSKKKRKFGRDGEEEWNSDGKSGRVLSGSDGARSDNEGGEVRGRSRNTRRDDPRRHTLGGDQQYLAMSGQGGPLSRTMDLEMSSTRARKGQPRGYPPHTNPMLFDDDPGIMSEVETSSTGFRRGGKQRSSLPVVRTPSKTLERPLGLVFLQYRNETKRALLPNEITSIDTVKALFVRSFPKQLTMEYLDSPNVKIYIHDSSKDMFYELEDLRSHLREIRDRSVLRLFESADVSGGLPMAGIGIAGGVGHFEDPSYFSEPEFDSEYQHQHIHKSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHX9</accession>
    <name>A0ABM5KHX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050509809.1">
        <property type="nucleotide sequence ID" value="XM_050653852.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653852.1">
        <property type="protein sequence ID" value="XP_050509809.1"/>
        <property type="gene ID" value="LOC126886794"/>
    </dbReference>
    <dbReference type="GeneID" id="126886794"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25154" checksum="9B201C3778DDE824" modified="2025-10-08" version="1">MAHTYKVRYFNFTARGEPIRMLLSYGEIPFEDERIAREDWPKIKPTTPLGQLPVLEIDGKQIPHSISICRYLASIVKLDGKDARENLRIDVAVETLLDLQKLAFEYVFETDAAKKDEKNKKVKESVPLFLGKLEEHAKQNGGYTALDRLSWADIIFICIYEGLMNILGKTTFDSYPSLQKIKKNVLDVKSIRNWIKNRPETPSTMGPLKFEYDLKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKH0</accession>
    <name>A0ABM5KKH0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510699.1">
        <property type="nucleotide sequence ID" value="XM_050654742.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654742.1">
        <property type="protein sequence ID" value="XP_050510699.1"/>
        <property type="gene ID" value="LOC126887311"/>
    </dbReference>
    <dbReference type="GeneID" id="126887311"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31582" checksum="2FA236CD14C8163A" modified="2025-10-08" version="1">MQPPTEKPATKKYQTLFNNQPLTCPWNSAQPYPNASSRNHTEPSTSCNNKNKATPTIQQSSTQFFYFLRLMQLFPETHPATIHTVLTLCNNNFFQAVDKLLYAKKCKALYNRNQSSYRRSPYERSQTSAGHVHSGVCRKEEVINLKQGQKFKTTSKVFQEDLKKTEYFSGRTQNSTCVVEAHSDTSKCTCQMNSLQVPQTNTLVTDNLSNQVTAYNDPISINTEFKNSADDTIKVRTPELSSDTPTSDSSPSKDNKWENLSELSPESQTIIKSDIIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL82</accession>
    <name>A0ABM5KL82_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510957.1">
        <property type="nucleotide sequence ID" value="XM_050655000.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655000.1">
        <property type="protein sequence ID" value="XP_050510957.1"/>
        <property type="gene ID" value="LOC126887458"/>
    </dbReference>
    <dbReference type="GeneID" id="126887458"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="659" mass="76649" checksum="3313A56EA09B220B" modified="2025-10-08" version="1">MSYIKNYIVKLFDKPRELVIMPKGDDKTVFSVPPEYLPDQYKPIGNQIVTRFGQEAEGGKIPVNTISIPPLGEILDIKRDENFSLFIPKHRRIAGQLINIYLGMRNVDDLLSVAVYTRDRINPHLFNYALSVAILHRPDTQNVDLPSFIISFPDKFVDGKVFAKAREEATIVPDGSRTPIEIPRDFTASNLEPEHRLAYFREDLGINLHHWHWHLVYPHEAAFQVVNKNRRGELFYYMHQQIVARYNFERLCNGLKRVERFLDWRKDIAEAYFPKLDSLIASRTWPARVSNEKLSDLKREADQIVQDIADLERWRDRIFDAIHNGRVMRRDGSFMNLTENEGIDILGNIVESSILSPHREFYGDLHNMGHVFIAFIHDPDNRHLESHGVMGDTSTAMRDPIFYRWHGFIDNIFQQFKSTLPRYTIDQLNYSGVTIESISIESETEKNIFNTFWQQSDVDLSRGMDFQPRGPVFVRFTHLNHQPFSYRIVVDNNGAVRQGTCRIFMAPKFDESGRPWLFVDQRTMFIELDRFRVDLRQGQNTITRASTESNLTIPFERTFRDLNANRPQGGDDLVQFNFCGCGWPQHMLIPKGDTDDPGFRCELFVMISDYEGDKINQDTSGVCNDADVFCGVKDKLYPDRRSMGYPFDRQPRRGVDTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPE3</accession>
    <name>A0ABM5KPE3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512053.1">
        <property type="nucleotide sequence ID" value="XM_050656096.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656096.1">
        <property type="protein sequence ID" value="XP_050512053.1"/>
        <property type="gene ID" value="LOC126888074"/>
    </dbReference>
    <dbReference type="GeneID" id="126888074"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="455" mass="50574" checksum="2BF835D62181F1A8" modified="2025-10-08" version="1">MSSDVTIQDVPANKSYSTAASQQNFFPGKENAILFSAINNTPLQDYLISLGNLINPKNILFSSRLSNNRICMYLSSKQAVEDFMTNYGSIQVNGETVRARRLITPAERIVLSNVCPSIPHEVIIQELKHLGLNLVSPITFLKISASLPEYSHIKSFRRQVFISPHNTTIPNSILLNYDNTNYRIFISQDSMTCYICKQINHIASNCPSNKNSSSQPSGPLTPPTVQSSDSPTNAGNQVDQTSNNDQNKNTEIFPQVSIPNTSNSTSVEIIQPVSEATQDLKTNENTPLESSATAENIEIISQTSLAITKESPCPSTKRTIEETLSPPVENVVDNQTFLLPAQPHKTKTQKNKKPKRSLPIPESLESYLSKQSTPSILSYDQLMMLIENIQGSQSPIEIVKEFTSDFLGLVNLLTVSYQYIPDRATKYRFTRLKTLLLRFLGEEATTESELSSTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPJ0</accession>
    <name>A0ABM5KPJ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050512107.1">
        <property type="nucleotide sequence ID" value="XM_050656150.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656150.1">
        <property type="protein sequence ID" value="XP_050512107.1"/>
        <property type="gene ID" value="LOC126888148"/>
    </dbReference>
    <dbReference type="GeneID" id="126888148"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="175" mass="20300" checksum="67F29D2E2323508E" modified="2025-10-08" version="1">MVLMAVVNANYEFIIYEFGVNGRICDGGVIEQTIFYNKLKENTLQIPVFDHLSGSDKMLSDVFIGVEAFALAPHFLKPFNQRELTNERKIFNYRLSRTRRVVENAFGILANRFRIFHTTINLNLKTVYIIVMTYCVLHNFLRSKYASTYTPIGSLDDDNRNGLRTEDSNLIDMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV69</accession>
    <name>A0ABM5KV69_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514086.1">
        <property type="nucleotide sequence ID" value="XM_050658129.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658129.1">
        <property type="protein sequence ID" value="XP_050514086.1"/>
        <property type="gene ID" value="LOC126889635"/>
    </dbReference>
    <dbReference type="GeneID" id="126889635"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046843868" evidence="2">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="190" mass="21440" checksum="EF06AC880B0107FB" modified="2025-10-08" version="1">MRTVQLYFILVLCIFTVSTAPVPQDIDEFEEIQAEKEAEIKAETAEKIAAETKKEMKKLEAEVKEDEKEKKKEVESLKKLEEKSEAAEAAAAVKSEKEAKAAKIEAEAVEAEKVAETKVKTVEKSAEAKKAAVAKDVGDLARDLTCLGLSEDHDHDYHELDLCEILEKAQFQPVWQPCENNMYNFFSRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV77</accession>
    <name>A0ABM5KV77_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514097.1">
        <property type="nucleotide sequence ID" value="XM_050658140.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658140.1">
        <property type="protein sequence ID" value="XP_050514097.1"/>
        <property type="gene ID" value="LOC126889637"/>
    </dbReference>
    <dbReference type="GeneID" id="126889637"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="133" mass="15957" checksum="E7A7CA4C30E8C063" modified="2025-10-08" version="1">MKEDEEKRRQEEKVEKEQRREVKEKRRQEVEEMRRQEEEEKEERHRQEEELKEESRRQAKVEVMNITNVESEQTAFSSSIVDPGTIRSSKILNPPTFDGQTAWETYRFQFENGWNENAMAASLVVSLRGTFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWR2</accession>
    <name>A0ABM5KWR2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514625.1">
        <property type="nucleotide sequence ID" value="XM_050658668.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514626.1">
        <property type="nucleotide sequence ID" value="XM_050658669.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514627.1">
        <property type="nucleotide sequence ID" value="XM_050658670.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658668.1">
        <property type="protein sequence ID" value="XP_050514625.1"/>
        <property type="gene ID" value="LOC126889929"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658669.1">
        <property type="protein sequence ID" value="XP_050514626.1"/>
        <property type="gene ID" value="LOC126889929"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658670.1">
        <property type="protein sequence ID" value="XP_050514627.1"/>
        <property type="gene ID" value="LOC126889929"/>
    </dbReference>
    <dbReference type="GeneID" id="126889929"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08031">
        <property type="entry name" value="LARP_4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12430">
        <property type="entry name" value="RRM_LARP4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058699">
        <property type="entry name" value="RRM_LARP4/4B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF131">
        <property type="entry name" value="LA-RELATED PROTEIN LARP4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26088">
        <property type="entry name" value="RRM_LARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="67"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="750"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="833" mass="91076" checksum="9FB2EB98682D39DA" modified="2025-10-08" version="1">MHGYAYMNGDVGKVPSGVVFSTAPESSSAMGTHPDYVAVNGVAEGAEGPSPLTPSAPQENASQSQSAYPLPQLKQMLAQQLEYYFSRENLANDTYLLSQMDNDQYVPIWTVANFNQVKKLTKDIKLITEVLRESPNVQVDEEGLKVRPNHKRCIVILREIPDNTPIEEVKNLFAGENCPRFISCEFAHNTSWYVTFESDEDAQRAYRYLREEVREFQGRPIMARIKAKPMNRLPIPPVTGVKNGFRATPPPTAVYDPAAFPPGQQRFIYTNGTPGQPLPAYNQVVYPPYQPQPFYASVAWPPSGPGLYDISSVFSVNGLAPQNFKHPTTYRTNQNRPRKQSRSAVPSDQSSQGSQGGSSNGQGSSRQATSYQARSHSPLNSSSKGNPSKGPTSEGAIPKNSHIHNVANDNNEAHIANHTTPIGLPVMHADPVDMYKVAKEVIPPRHRRKKRDEDGALNGQSVQTQTREPVNSRGTEFDLIEEAFPPLPGLDMGSQPNYKHQVTNSILEVTLSSQSLIETQPVPQQGHWGENRLADVVKGTAKFKGSSVGGSSKESSSGGGDDSPRAVSPQHFPSCNQTTRQNSVSTSTGPLDCKDVSSESGDIQLSTVTLTPPSSPEKLVPALPIKCTMADKSTKTDDVLLNGDLDVPCPTTTNAATMTTVVPTEAPSRSGVAVTTTNSTKNHIPVHRQDSKSETSRHVSISPPPIIDYSGNPPRKSYAQVAQHHKDAHVQKEQQVKDKQIEASSTSVPSTKTTQSITNYTTSSSNNRGQIERDNKDRDNGPQRIESGGNGNQQRYNGMNRGGARSGHERSQRRRTEMRTSQLRDFVTPRSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXR7</accession>
    <name>A0ABM5KXR7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514988.1">
        <property type="nucleotide sequence ID" value="XM_050659031.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659031.1">
        <property type="protein sequence ID" value="XP_050514988.1"/>
        <property type="gene ID" value="LOC126890177"/>
    </dbReference>
    <dbReference type="GeneID" id="126890177"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="209" mass="25008" checksum="3DCBAC8DDEAB4AF1" modified="2025-10-08" version="1">MMHDLTTETKNLTTEVKEIKNEQRKYWEELNDLKTELEKVKQENQTKHKEKEEMKKELNYMKIRVQRLEKERKVNNVVIQGLPIDTIDRNALKQTVGNFMEKEMNINVQIEEVIKLGEKTCLVKLQNKFEKEKIMQNKAKLKHIKGNKVYINNDITKEELQTQKKIRQVANEEINKGYQKRFYVSDTLPEEMEFTQLENIKAYTKCLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXZ4</accession>
    <name>A0ABM5KXZ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515066.1">
        <property type="nucleotide sequence ID" value="XM_050659109.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659109.1">
        <property type="protein sequence ID" value="XP_050515066.1"/>
        <property type="gene ID" value="LOC114331160"/>
    </dbReference>
    <dbReference type="GeneID" id="114331160"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="207" mass="22662" checksum="2B4C6B4CBC4FF4D4" modified="2025-10-08" version="1">MSSVSVFCCLKGCLDNFTFHPTVPHVPRDNPIQLDTAFMGYEVVVVKGGLRLCGSGAVLGNAPLVQSKSYFEVKVQQNGTWAVGLATRQTDVSLTQGGQDEFSWALGSDHIIRHKKQELHKISFPGSPDEGINQIIEGDIIGVAFDHLQLKFFINGKEVDYAVSNIKGTVYPALYVDDGAILDIILDNFNHPPPSGFEKIMLEQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZB1</accession>
    <name>A0ABM5KZB1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515526.1">
        <property type="nucleotide sequence ID" value="XM_050659569.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659569.1">
        <property type="protein sequence ID" value="XP_050515526.1"/>
        <property type="gene ID" value="LOC114329106"/>
    </dbReference>
    <dbReference type="GeneID" id="114329106"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF11">
        <property type="entry name" value="GH09980P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="973" mass="108907" checksum="E328F816ED48BD99" modified="2025-10-08" version="1">MCFLCHYCKAAFDNGQNLVCGAWTSLRNCRPVRRGLQITQRCVHLAAGNTAKMTNKTLSWLCVCLCIALAAAQSNYADQANNIAYQGEGLPEQGILDGKVTKLDDLSPVIFLNRTKAALNCAAGSMQIELKFNDKFYGIAYAQFDRNSACRVYGKGAFSYKLELPLKGCGTKQGPQRVFTNNIVVRFNPHFEIDGDEVITIVCRYPPPIVPPPAPLPHIVSEAPASPIVAAPLKGFQILLIICGILFLSLLLLGLGCSYYCLRRRPLTVIRQPFSTLGSGSEITKISRSSLGSLPIMEGVKIPRANVLPYTAAASSAGSEGPLMSDNLPSDYPSESHSEIDVDTGSLPVSSAGSYDNQAYIQDNSSVYSEGYGHTVEQHVQNAVATTAMVPRLPLAVKEQPKFDIQVKVKKSPPPPPSISLSDTESTRTDRNLSTILEQQESIRSLDSPLVHERNQFTYVPELHPPPKHIQPAPTYNKILRRQMEMQEERYVAPTPPPPPPIIPKRERLTEDVPDTFEPPIAIVHKPEITSHMVDDVFLKTITEKKTIEDIERHRRLVTEYHTRAKPVDDQKWNVTIRNYPVDMAEPPEWENFSDISSASGLTLTPKPERATMSLPPQNLIVDDKLPLNAPEIVANLGAPSPPRYTTTSEVHTREESYLSMFNIPPENPEVPNWNVLIRVFQPTEQEEGPVIDSAETFNSQLTTADKMKWRQIITTESTLRTLLTECVIREDYERVRSDTRYTNIFEQPKWDVIIRILAPPDRQPKSKKWDNRSRRSSLPTLYEYDSDGESSVRTLTREPLVLPQRSRKNSNSRSSYRSEADLRSMSEMTVDFGRQDNFSETSSYYPDKRYYEDSEHGHPSLARSLSQPSLARSASEFTERWVAPSRYDTASEFTSPEGTPKSQRSSRFQPPRGTGEQRAVWQTSQASTTAGPRGTSQVVTQEFRSQASSSYVGRSQPPKGWFGDNDSEASYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0X9</accession>
    <name>A0ABM5L0X9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain 3 AAA+ lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516094.1">
        <property type="nucleotide sequence ID" value="XM_050660137.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660137.1">
        <property type="protein sequence ID" value="XP_050516094.1"/>
        <property type="gene ID" value="LOC126890959"/>
    </dbReference>
    <dbReference type="GeneID" id="126890959"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain 3 AAA+ lid" evidence="1">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23798" checksum="3444909EF6308A39" modified="2025-10-08" version="1">MPYDIVHVYNIDKRKHKDLIDSKLDRRRRGVFGPPVLKRQVFFIDDFNMPALEVFGAQPPIELIRQWMDFGGWYDRKNIGEFRKIIDINFVAAMGPPGGGRNPVTARLLRHFHYLTFLEMEDDSKLKIFGTILDFWLHRAPEGFEKYFNQMLTSTLTVYTTILHELLPTPAKTHYTFNLRDLSKVFQGILMFDAENLQVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1F9</accession>
    <name>A0ABM5L1F9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ty3 transposon capsid-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516269.1">
        <property type="nucleotide sequence ID" value="XM_050660312.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660312.1">
        <property type="protein sequence ID" value="XP_050516269.1"/>
        <property type="gene ID" value="LOC126891132"/>
    </dbReference>
    <dbReference type="GeneID" id="126891132"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ty3 transposon capsid-like protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="254" mass="28831" checksum="5F7A95ED67E80490" modified="2025-10-08" version="1">MSADQFNELLRTVAASPGTNNSSGSFSKCTARFSGKRCHNTVETFITTVSIYKEIEKISEADALKGLPLLLTDNAAVWEQGVQNEAKTWNDATQLLRTAFSPSKPAHQVYVDIFNNKQQSNETIDEFVTQKRALLAQLPLNRHDEQTQLDLIYRLLSLHIRKKVPRNKITTFSELLDKGRQCEEIRKEAIPDKGIDEKQGTSTKRKPARCGFCHFKGHTTDVCRKRQTKENEKHPDTDKAPDTQNSMKELPQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1I0</accession>
    <name>A0ABM5L1I0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516297.1">
        <property type="nucleotide sequence ID" value="XM_050660340.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660340.1">
        <property type="protein sequence ID" value="XP_050516297.1"/>
        <property type="gene ID" value="LOC126891158"/>
    </dbReference>
    <dbReference type="GeneID" id="126891158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="132062" checksum="7414A1D4742AE65D" modified="2025-10-08" version="1">MINETKYFTTSNSAIYRDTNLDEWFEKKVVEPISRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIELPPQIKRKEACVNVKNDDEACFAWAIVSALYPATKDAQRVSKYPHYSDVLKLKGIQFPMTIKQTPNFEKQNNISINVYTLKKEKKNYTTLPILLTKNRKDKHINLLLIQDNYDEPPTQYHYVWIKNLSRLLSKQLSTEDGTKYFCDACLHYFRSQEQLNAHKTCCKGRSDVICDRCLQPFSSSKQLEAHTTDCVRINETAIKLPDESRKMLRFKNYRNKIKAPFAVYADLESTLKRTGDPKKYQEHIPVAVGYFFKCSYDDTLSFYNSYRGKDCMKWFADELNRLAENVSTVFMCPYDINITSQQERDFHAATHCHICEQRFSPSDKKVRDHDHMIPEHNYRGAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVNDIATHIKGPVDLLPITKEKYISFTKHIDHARIKFRFIDSFRFMASSLDKLSLYLTEYPNLCSQFLSLSEENFNLLTKKGIMPYDYIDSFQKFNETCLPPQEAFYNKLEDKPCPRRHYRRAQDVWSSFSCSTLGDYIDLYMKTDILLLADVFEQFRSSCLKTYNLDPAHYFTLPGFTWDAMLKHTIQELELLTDPDMFLFVERGIRGGLSQVCSKPRVHANNKYMTSYDPSKPDSYLMYFDVNNQYGWAMSQFLPYGGFEWVDVNIDVLSIPDDASEGYFLEVDLEYPQHIHDRHKDLPFCPQSLNPKTMLPPKPPREQTKLMATLHDKERYVIHYRTLKQALAHGLVLKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTMENVRKRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLVAVEMHRAEIWLDKPIYVGMSILDLAKTTIYDFHYGYLDRRFGENFTTCYTDTDSVIVEIREKDPYEAMKTDCHQHFDTSDYPKDNIYSIPQVNKKVLGLMKDENNGCIMTDYIGLRSKLYTTKVAITDNDVMKLRGKLIDQEYEDDEIEILIKNYGVTKKAKGVKMSVVQNKISFHDYVECMETMTTKIAAQNLIRSDKHQVYTITQSKIALSPTDDKRYHLPESYDTLSWGHYLVDNLKMDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2K9</accession>
    <name>A0ABM5L2K9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516679.1">
        <property type="nucleotide sequence ID" value="XM_050660722.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660722.1">
        <property type="protein sequence ID" value="XP_050516679.1"/>
        <property type="gene ID" value="LOC126891546"/>
    </dbReference>
    <dbReference type="GeneID" id="126891546"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="136586" checksum="6534AD87E762E638" modified="2025-10-08" version="1">MQNLKLERETIKGSLKKVFRDIEEVNPSDEKTIQRLLQQVDDKAERIFLLDNSIKDILFAEETRTETISKELNDEENFRDEVGKFRIECEYLIKNLKTLKDQENKGTKNEKPVKNLHLPKLEIKKYDGNVKNWINFWGQFRKIDEDADLPNEDKFQYLIQSTEDGTPARSLVESFPPSAENYKIAIDQLKNRFARDEILIEVYVRELLNLILNQQTSKEDPGMALSTLYDRLETQLRALGTLGVTSDKYAAMLLPLVESALPYELLKIWERNRASNNLKFNNELQGLLEFLKTEVEAEERVKLAQSSFTVPKSIDDKYTVETLHTESLKTKGKQKFSCIFCESNTHASQDCIKAQKMTLEQKKSIISKKRSCFSCLKQFHNFRTCKTTVKCIKCARKHFTLMCPDLHEKENKNRDLQKSESLENTLTTVASETLLQTINVRVISDNKRSMKVRALLDSGSQRSYITTKCAEDLGLTKIGQENIVQGVFGGLQGAPKIHRLFKAGIENLENSFSIGLSLLEQSKICNYVPKLIDQKVLDLLKAKNIYINDSASKELEVNLLIGADMFGHIITGNLVNINDSLVALETKFGWTVMGTQKSNNKINTFVSTYFTDSLSTLWSLDVLGIKDPAETKCREELDIRTLEKFKESTVVNSENRYEICLPWAEGYPAITSNFNLAEKRLFSTTKRLISLNKLTEYDNIFQDWENTGIIEEVEEEPLEKNTHYLAHHAVVKESSLTTKIRPVFDASAKDGNGNSLNDLLEKGPNLIELIIPLILKFRLHKIGVTSDIAKAFLQISISEKDRDFLRFLWWKNYEKREIKIFRHCRVVFGLKPSPFLLAATVNLHLEKEKTYTETANQLLNAFYVDNCVFSVRNETELKKFIDESTEILKNAKFDIRGWTFNENNDTYVSSVNEKLENKVISILGIQWNYQTDTLACDLKSLDSLDEIPRTKRGILSATQRVFDPIGFTAPFTLIPKILLQETCSLKLTWDQKLPDDIKKRFEIWLKSVKCLNFCNIHRYLAYPEEENLIINKTLHVFVDASKYAYAACVFIRLEFQNSISIKLLLAKSRLSPVKTITLPRLELMAAVIGVRLLETVKEVTDFTELKTYYWSDSMVVLTWIKIKGLWNTFVGNRVKEIKKYSAVDQWRHVPGDMNIADVLSQGCSGKQLLEKQWWKGPQWLKEPENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L448</accession>
    <name>A0ABM5L448_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517217.1">
        <property type="nucleotide sequence ID" value="XM_050661260.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661260.1">
        <property type="protein sequence ID" value="XP_050517217.1"/>
        <property type="gene ID" value="LOC126891915"/>
    </dbReference>
    <dbReference type="GeneID" id="126891915"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="473" mass="55640" checksum="5F9814E56720BF11" modified="2025-10-08" version="1">MEVKQESIINFPKEECEIKVENIDVHDVEVSYSVKTEVKDELLESCSPNNDTHSNFDDANSIDSQTKAFYIEDIKLEEEDKPDIIPIENGYLQNENKMEVMETPTSEHSFYERNYVSPQAEEKTLNENVKVAIGQTSYKCEICSKQFTQASSLKTHSRIHTEDKLYKCEICLKQFITAGNLKAHLRVHTGETPYKCEICFKQFITPSKLKAHLRVHTGEKPYKCEICFKHFREAGNLKTHLRVHTGDKPYKCEICLKQFITACNLKTHLRVHSGDKPYKCEICFKQFITAGHLKTHFRVHTGEKPYKCEVCFKQFSATNSLKIHLRVHTGEKPYKCKICFKHFRETTQLKKHLSVHTVVNLHKCEICFKQFITAGHLKTHFRVHTGEKPYKCEVCFKQFSAKNSLKIHLRVHTGEKPYKCKICFKHFRETRQLKKHLRVHTGENHHKCEICFKQFIRIDHLKRHLRFTHWEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4G6</accession>
    <name>A0ABM5L4G6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517325.1">
        <property type="nucleotide sequence ID" value="XM_050661368.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661368.1">
        <property type="protein sequence ID" value="XP_050517325.1"/>
        <property type="gene ID" value="LOC126891989"/>
    </dbReference>
    <dbReference type="GeneID" id="126891989"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="286" mass="33617" checksum="919670E82CEFBEC1" modified="2025-10-08" version="1">MPGTNCSVAVCRNNFYKNKKSADDADQQIAFFTFPKDKKLEKIWIERCCGKDEIKTKTARVCSNHFKKDDFVDDMYARIMGTRPKLKLKNGAIPSENLKYLGDVSKQTTAISDKMIEMKTQKAIVEELLEVYSHERIIDVSDVPSTSNESEEDILKRKYEELLKENKKLKEKLEENEQDLYTTRTRIVELNKRIKEKDIDSEKNILKRLGHMFSKNEIEIILKKKTRACWTTEEISKAFTIRYFSRRCYLYLRNTLKYPLPGISTLQNWAAHINLRSGLLQDVYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5T9</accession>
    <name>A0ABM5L5T9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517805.1">
        <property type="nucleotide sequence ID" value="XM_050661848.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661848.1">
        <property type="protein sequence ID" value="XP_050517805.1"/>
        <property type="gene ID" value="LOC126892336"/>
    </dbReference>
    <dbReference type="GeneID" id="126892336"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="131" mass="14034" checksum="8D77B223766427C4" modified="2025-10-08" version="1">MSGPGKGGKNKAAKYKTRSNRAGLQFPVGRTHRFLRKGNYAERIGSGAPVYVAAVLEYLVAEVLELSGNAAKDNKKSRIIPRHIQLAIRNDEELNRLLSGVTIAQGGVLPNIQAVLLPKKTGTKSAATEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L613</accession>
    <name>A0ABM5L613_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517882.1">
        <property type="nucleotide sequence ID" value="XM_050661925.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661925.1">
        <property type="protein sequence ID" value="XP_050517882.1"/>
        <property type="gene ID" value="LOC126892393"/>
    </dbReference>
    <dbReference type="GeneID" id="126892393"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="644" mass="72683" checksum="4160699786F2567D" modified="2025-10-08" version="1">MKRQLGLDSFFSKKIKAKVDQETVNEGLSNTNGSQTPISSISTASKPSQCGPKSDSSESELQIPPRDFGHLINKNETLIMSNNERYEWLTNPWTPSPEFKFPLNIEGKKNRSFQTSWLKQYPWLVYSKKLDGGLCKVCILFGRGEGGKSDGKLGKLVLEPMKTFKKATETLKIHNGTKYHNENMIASKHFSLVMDGERADIVCSLNSAQKAVEEENKKKLIPIIKTIMFCGMQNIPLRGHRDDGQLLNETDSEPHREGNFRALLRFRIDAGDKQLEEHVKSCGKNASYISKTIQNDLISCCGEVITNQIVSQITYAQFFTIIADETTDMSTKEQLSICLRYLDKLTLEIKEDFIMFIDVVDLTGENIAQKILEALDSLSINIADCRGQAYDGGSNMSGKFQGAQARIRKIQPLAMYSHCASHRLNLVISKACTIPAIRNAVGVVSSVANFFRESAKRLHALDDERNEEIKKGKHAVKKMCETRWLERHDAVLTFLSSLPSLHATLETMVYSDQAAGNNAFSLLHSILSSEFIVSLVVLENVMTLTLPLARKLQAEYMDVLNAMTLIDATLKSMQEQRANNEECFKRLFEKAQNLASKMETELKKPRLVGLQRNRPNVQTDTVEDYFRLSIYLPFLDFLVCEMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6T5</accession>
    <name>A0ABM5L6T5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518155.1">
        <property type="nucleotide sequence ID" value="XM_050662198.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662198.1">
        <property type="protein sequence ID" value="XP_050518155.1"/>
        <property type="gene ID" value="LOC126892617"/>
    </dbReference>
    <dbReference type="GeneID" id="126892617"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="694" mass="80278" checksum="0300A945D9B7DB30" modified="2025-10-08" version="1">MFNQSAVKQEIAETTCKREIDNEVDEVLEDTCKIEVKEEGIRESANDAFDYLDVKKYPIKAEIKQDDGFCCKDMKTVARSLLTNDDLSDSNLIPYITSPTNVTAGGQRFMCIICNKPLSSSSRLALHMRIHTEEKPFACEICTKQFSKKAYLKSHMIVHTGEKLFECEICTKQFSLKGNLTKHMKLHTGEQPVACEICTKQFSRKLYLKTHMSVHTGEKPFECEICTKQFSKKAYLKRHMTVHTGEKPSECEICTKQFSTKSSLKIHMTMHTGDKPFECQVCNKQFSTNSILKTHMKLHTGEKSFECEICNKQFSTKPLLKSHMTVHTVEKPFGCEICTKQFSMKHVLKRHMVVHTGEKPFECEICTKQFSTKPILQSHMTVHTGEKPFTCEICTKQFSRNAHLTIHMRVHTGEKPFECKICNKQFSQSSSLKYHMRMHTGEKPVECEICTKQFSTNGNLLRHMRNHTDENSFECEICTKELSPKSSLTMHMKLHTCEKSFECEICNKQFSTKPLLKSHMTVHTVEKPFGCEICTKHFSRKQVLKLHMTVHAGEKPFNCEICTKQFSMKHVLKRHMVVHTDEKPFECEICTKQFSTNPILQSHMTVHTGEKPFTCEICTKQFSRNAHLTIHMRVHTGEKPFECKICNKQFSQSSSLKYHMRMHTGEKPFECEICNKPFSAKRLLNTHMRVHTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8Y9</accession>
    <name>A0ABM5L8Y9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518905.1">
        <property type="nucleotide sequence ID" value="XM_050662948.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662948.1">
        <property type="protein sequence ID" value="XP_050518905.1"/>
        <property type="gene ID" value="LOC126893011"/>
    </dbReference>
    <dbReference type="GeneID" id="126893011"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="221" mass="25236" checksum="E9C19693755DDCDF" modified="2025-10-08" version="1">MTRVRSRSPPRSKALSPPRYADSKESLLLQHPEESSDDHSSDQEDGKDGFTIQNRRIRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTRANEEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKPEKKNPEKTDKKPPFPSITNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9E9</accession>
    <name>A0ABM5L9E9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519067.1">
        <property type="nucleotide sequence ID" value="XM_050663110.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663110.1">
        <property type="protein sequence ID" value="XP_050519067.1"/>
        <property type="gene ID" value="LOC126893158"/>
    </dbReference>
    <dbReference type="GeneID" id="126893158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="310" mass="35718" checksum="28A142319C751DD6" modified="2025-10-08" version="1">MDRPTQKIPMGDKDDEHRQNIQENEKENDSKPNGGEQSLDDFRKDEEEEMTSFEKELLSTHNERRRMNRSTVQKQSTLVGETIDLEDSENDKEDIGEEKSQADAEEMEEGWRNALQQSVLATILLEEERDGGSINTKKKKGGQHRQRRKETYFTITRLDPGVSEKSLKKSIRSYTGIPEEEVDVRVLRTNKYGEQVATITVRPSKAEELRKYGSIKVGWVICPVMERHNPIRCYKCLKFGHNTYDCKEESRAACCYNCLKNGHTAVNCTNKAFCLVCKEEGHRMDRMACPAYRALVYGRRGEGEPPLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9Z6</accession>
    <name>A0ABM5L9Z6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519266.1">
        <property type="nucleotide sequence ID" value="XM_050663309.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663309.1">
        <property type="protein sequence ID" value="XP_050519266.1"/>
        <property type="gene ID" value="LOC126893291"/>
    </dbReference>
    <dbReference type="GeneID" id="126893291"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="255" mass="30161" checksum="C2B03168F7A10F5D" modified="2025-10-08" version="1">MAEKTIKDKTITSLYAELNKFNQNGEYERSLKTSNKILGVAPHEFLAFQCKMVCLIHLSRFEEAISLMNKNPQFLQEVIFEKAYSYYRVNKPEEALKTIELSENELDFRCKELKAQILYRLEQYDNSVSIYRDIIKNMHDDDYDDERYTNLSAAMVHLKNENAMDTINEFVENTYEQCYNKACLLIEYENYLEAEKKLKQCEKMCREMLEEDETTEEEIDIELALIRFGNTLKIKHLLKPLVQWCSDLHCMGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXT6</accession>
    <name>A0A6P7EXT6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-tocopherol transfer protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114324370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127989.1">
        <property type="nucleotide sequence ID" value="XM_028272188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EXT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272188.2">
        <property type="protein sequence ID" value="XP_028127989.1"/>
        <property type="gene ID" value="LOC114324370"/>
    </dbReference>
    <dbReference type="GeneID" id="114324370"/>
    <dbReference type="KEGG" id="dvv:114324370"/>
    <dbReference type="InParanoid" id="A0A6P7EXT6"/>
    <dbReference type="OrthoDB" id="440711at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF234">
        <property type="entry name" value="SD01558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="134"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028127989.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37059" checksum="96C793F2F86A8D2F" modified="2020-12-02" version="1">MREVELKIQCMSHPSLESPQKKETTFKGTFDLEEPSQELLQWAKENINEDPDTRDLLISELKDMIYERGECTPTRTDDEFLLRFLRARHFILKKAHRLYVNYHNFIQEAPEYFKNVNLQKLTEIKKTKMFNCPLSRDQSGRRMLIYNIGEWVPSDFSPTELIQFVIFLIQISMLEQKTQINGVVALFDLSGLSLEMVWYMSPTLAKHMVNIATTSMPCRLEGVHFLYSSWMFDTAFSMVKGLVSPTVTDRIHFHNDLETLYSHIDPKYLPNSLGGAQEDYSLESWYNDILETHGETVKTELESLGYPVKEFLDSIGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYS3</accession>
    <name>A0A6P7EYS3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114324183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324183</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127742.1">
        <property type="nucleotide sequence ID" value="XM_028271941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYS3"/>
    <dbReference type="FunCoup" id="A0A6P7EYS3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271941.2">
        <property type="protein sequence ID" value="XP_028127742.1"/>
        <property type="gene ID" value="LOC114324183"/>
    </dbReference>
    <dbReference type="GeneID" id="114324183"/>
    <dbReference type="KEGG" id="dvv:114324183"/>
    <dbReference type="InParanoid" id="A0A6P7EYS3"/>
    <dbReference type="OrthoDB" id="8195120at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028127742.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19806" checksum="A5D3CA8FFCB33AC5" modified="2020-12-02" version="1">MENKNFVPDNIPAADLDKSWHIPRPTLARSSKSSQGSTSSNNSTQSVRSGSLLLTAANLAQIHHLQHPPDVENPPPTTEASTRDQNIRYYLQSQSVDGIDHLPPSIDVNKKKEPDTVSVASSTHFTVVNVNTRQKQPQRSFCRKHQLTILVLTMSTIFTIGIMAAILLLELRAQNQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZT1</accession>
    <name>A0A6P7EZT1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein Nkx-2.2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114324841</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128521.1">
        <property type="nucleotide sequence ID" value="XM_028272720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272720.2">
        <property type="protein sequence ID" value="XP_028128521.1"/>
        <property type="gene ID" value="LOC114324841"/>
    </dbReference>
    <dbReference type="GeneID" id="114324841"/>
    <dbReference type="KEGG" id="dvv:114324841"/>
    <dbReference type="InParanoid" id="A0A6P7EZT1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028128521.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35120" checksum="AB7997173152AC1D" modified="2020-12-02" version="1">MAGYDDYTPYENTWHIIPPDYIHLEEEYRYPLLDTMKMTGTTIANQRQPASFAISDILELDRQNSEEIDPITTDMSVYPTHHDLSYSTRHQWLQVPEPGMHHAPPHLTIPPHSSQLSPDSTSPAISERSSVPPDTPLGDSNMTNPLNQAPSSMGTISEGEMEEQDDIKEEEGEQQSNGPKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASIIRLTPTQVKIWFQNHRYKTKRAQHEKGMHDQQNNPMPSPRRVAVPVLVRDGKPCLAGGQKTDNVPLPSSMMMANHAAHPLMYGQPRVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0P9</accession>
    <name>A0A6P7F0P9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325110</name>
        <name evidence="11" type="synonym">LOC114325109</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128850.1">
        <property type="nucleotide sequence ID" value="XM_028273049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128851.1">
        <property type="nucleotide sequence ID" value="XM_028273050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F0P9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273050.2">
        <property type="protein sequence ID" value="XP_028128851.1"/>
        <property type="gene ID" value="LOC114325110"/>
    </dbReference>
    <dbReference type="GeneID" id="114325110"/>
    <dbReference type="KEGG" id="dvv:114325110"/>
    <dbReference type="CTD" id="55831"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028128850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028128851.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27493" checksum="99797095E5B3A21A" modified="2020-12-02" version="1">MGADLIVDPQIRFWVFLPIVVITFLTGILRHYASILLSSQKKIELQQLADSQLLLRARALRENCGYIPKNSFLIRKQAFNKEDGYLMQKRPAVTQNMMTDPTMMTDMLKGNLTNVLPMIVIGGWINWMFSGFITTKVPFPLTLRFKSMLQRGIELSHLDASWVSSASWYFLNVFGLRSIYTLVLGENNAADQSKQMQEQMQMTGAASGMPADPKVPFKAEWEALEITEHQWKLADVEKDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0Y4</accession>
    <name>A0A6P7F0Y4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114325176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114325176</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128966.1">
        <property type="nucleotide sequence ID" value="XM_028273165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F0Y4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273165.2">
        <property type="protein sequence ID" value="XP_028128966.1"/>
        <property type="gene ID" value="LOC114325176"/>
    </dbReference>
    <dbReference type="GeneID" id="114325176"/>
    <dbReference type="KEGG" id="dvv:114325176"/>
    <dbReference type="InParanoid" id="A0A6P7F0Y4"/>
    <dbReference type="OrthoDB" id="6780401at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028128966.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="55642" checksum="8B0643CC1A857DE2" modified="2020-12-02" version="1">MSILIPDNILEILICSFCHKYLSVKPVKVYPNRLIQCGRCVDNQEPAAQKSQGVESLYGLIAEHVLFKCVNKFDGCRALLTYSQVLDHEKECLEKIHKCPICYEEMTSFLMLQHFHFKHKNAVLGYPTFVFNLNDYLDMPSVYIYQEEDNLFFLYTRCSKSENTIALYLVCMASYKLPQNIYHQFTVTSENKEFDIVLDPKPCTDDFFVVDISHMSNFIQIKFKLIDRNLKVLTGPKFSAAVRKPVPKNAPHGHEIGKNRQEFDLKAKCVKCQAYCIFSLSNCPVRYCYLNKHNNYMCYYCYQWFESWETSSQYFEIAIPSEIFGGMKFYKWNCSNCFSDISVSDMQSHEISCKLGRQFRCPMENCCEKGTTNQMIEHLKDHNRLAFSSPFQLTSNNLSCYVFLKEHIVSLLLIRTKNSIFCDVIVVILPQSEFAIKQFEVRTMFFDSNNQILNQYEINDNINPIFVKIIVEESRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4Q5</accession>
    <name>A0A6P7F4Q5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Troponin C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326305</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130421.1">
        <property type="nucleotide sequence ID" value="XM_028274620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4Q5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274620.1">
        <property type="protein sequence ID" value="XP_028130421.1"/>
        <property type="gene ID" value="LOC114326305"/>
    </dbReference>
    <dbReference type="GeneID" id="114326305"/>
    <dbReference type="KEGG" id="dvv:114326305"/>
    <dbReference type="InParanoid" id="A0A6P7F4Q5"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028130421.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19554" checksum="C9A4281AD0892D15" modified="2020-12-02" version="1">MSGTADKPDDELNYEEYKKLDISKEQLKMLKSIFDSFDLEKKKEIPVDMIGQILDMLGHRLTPDELQAIVKEIDEDGNGVMNFDEFAHLSARFLVEEEEDTEAILRELKDAFRLYDKEGLGYISVDLLKDILKELEPNLSPADLNEMIKEIDTDNSGTVDWEEFKAMMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7H3</accession>
    <name>A0A6P7F7H3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myosin-11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114327138</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131451.1">
        <property type="nucleotide sequence ID" value="XM_028275650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7H3"/>
    <dbReference type="FunCoup" id="A0A6P7F7H3">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275650.2">
        <property type="protein sequence ID" value="XP_028131451.1"/>
        <property type="gene ID" value="LOC114327138"/>
    </dbReference>
    <dbReference type="GeneID" id="114327138"/>
    <dbReference type="KEGG" id="dvv:114327138"/>
    <dbReference type="CTD" id="33739"/>
    <dbReference type="InParanoid" id="A0A6P7F7H3"/>
    <dbReference type="OrthoDB" id="5807119at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028131451.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="71497" checksum="6F56B773B942DC55" modified="2020-12-02" version="1">MASLNFVPYNQFYGQRQRYETIMSATMFTKIPETTKTKIPVPASPTPLRRHNSLRLRGEKPFTYPIGKRRDEENNIIIAKESPDQNHTASKDRNHNNNRFPFSDTTHHQSSFNPLLQRGRSFMERSDRGVQHGAKRPENMKIGNRSPVEVLKGGTTPVSPSRVRSLSLSLANVRQGNHSSKSPSIITSSPNRQISADSRNFSTGAIDNWDSESVTSIGSSVASCDHSSVAWNGTTFSGRSMKYVFHCNQHAGAVGDEYLTPTQRAQKQVKKLKYLLQQAQKDLEEKDSDILKLTKEVVELRLYKAALSSPEDKSNSSDAVTVRENNSNETTPEDAVDGLSNHLANDLNTSFADSGHFEDCTSSSVHSKESVLSEDCRTPSKSGRLVRLDKSTSTDQEIEHQKIIEEYERRFQELIKTHEEESIQLKQKHNEKIEELLQRISEINARYWQIVPELEEAKERIKELEHQLEEASKKLDEQNAEAEKTAKSEELLNRSEELVKHHNKIVELAQHPSRVSVPELLNELQVTRNELENIRDVEYATTSNNSQPLLSAKEALSLWVLGARKAMYRQLMEAKNKNKIDPEITLQFLKSAVYYFLTDKENSQGHLKAIQSILGFSSNEISSIERARQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7X2</accession>
    <name>A0A6P7F7X2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114325641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325641</name>
    </gene>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129555.1">
        <property type="nucleotide sequence ID" value="XM_028273754.1"/>
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        <property type="gene ID" value="LOC114325641"/>
    </dbReference>
    <dbReference type="GeneID" id="114325641"/>
    <dbReference type="KEGG" id="dvv:114325641"/>
    <dbReference type="InParanoid" id="A0A6P7F7X2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="209"/>
            <end position="262"/>
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            <begin position="574"/>
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        <location>
            <begin position="519"/>
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            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="256"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129555.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129555.1"/>
        </source>
    </evidence>
    <sequence length="748" mass="84735" checksum="3D06AE72A8B74E46" modified="2020-12-02" version="1">MSSGVVKDQEEGEIVDDDYEEISDNSMSFPLNESGKSQSVICLSSLSEFEEEDHQRRVGKMLKRGRKMKHHGHHRRKKKYFGKLHKSRKWKKLLKHIESSSDDESVDCRLVRKQLKAAIRVESPSVDTKVRTEGNQVNCLKNRLIAMTKLNDDSVIEQQCDIIKSDNENRTDDPIIDSGDTLEQTDIELTQLRLEALRTAVLNKFEDRKKRKHEELQKNQESPNIDNLETNKENSIQENGNIKQPSTDKPNLQPTTPDEEDEDVLRAMLLASMSRKMPKFAESKSLEEPVVEKVKSNQNVVKPFIVQAKKPVPLRQHQIKPIIINIGSDTESEDEKSTTDIINTKTTELPVNGYQVDKEIESTVENFLKEQRAKVDEVQAVTKQVVPPKNPTVEVTTPKSKIQPKRNESAVLEKSSVKLLTKEKQIEYQKLLQRLKMAQKKPKTRRVSVRGTEEGNNSRKNVKTKLINSPKPPIANKSFSVQQDAGNLHLILKQMQKEQNGRLQIEEKYVVLTPIIKKINEATTERRKYDQEVKRLLGALADAKRKLHNSHQTFSMYVKELTKMKEEIDKRPKTPIKRNGIATPPLTSTPNTSQISVAPLDVSKVSVTLNTTCPIPDTTNSTTLIAPTSQPSSPAPSTVLISETMLDRSGSECNMDIEEQHQGEIIVNCVDGKAESADELLSCGDPNDLSFSIVIPETESSSKGIPEYVSPLDHVKRESRIDPFVIICPYDICGKCRDTECTYKHYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F832</accession>
    <name>A0A6P7F832_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Axin-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114327508</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131949.1">
        <property type="nucleotide sequence ID" value="XM_028276148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F832"/>
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        <property type="interactions" value="1128"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276148.2">
        <property type="protein sequence ID" value="XP_028131949.1"/>
        <property type="gene ID" value="LOC114327508"/>
    </dbReference>
    <dbReference type="GeneID" id="114327508"/>
    <dbReference type="KEGG" id="dvv:114327508"/>
    <dbReference type="CTD" id="43565"/>
    <dbReference type="InParanoid" id="A0A6P7F832"/>
    <dbReference type="OrthoDB" id="10007451at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:beta-catenin binding"/>
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    <dbReference type="GO" id="GO:0060090">
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR014936">
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    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
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    <dbReference type="InterPro" id="IPR036305">
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    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46102:SF2">
        <property type="entry name" value="AXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08833">
        <property type="entry name" value="Axin_b-cat_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="113"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="750"/>
            <end position="832"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131949.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8F4</accession>
    <name>A0A6P7F8F4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBP80/20-dependent translation initiation factor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327394</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131801.1">
        <property type="nucleotide sequence ID" value="XM_028276000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8F4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276000.2">
        <property type="protein sequence ID" value="XP_028131801.1"/>
        <property type="gene ID" value="LOC114327394"/>
    </dbReference>
    <dbReference type="GeneID" id="114327394"/>
    <dbReference type="KEGG" id="dvv:114327394"/>
    <dbReference type="InParanoid" id="A0A6P7F8F4"/>
    <dbReference type="OrthoDB" id="6484979at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF18">
        <property type="entry name" value="RE28271P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028131801.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47847" checksum="53308407D0A91D0E" modified="2020-12-02" version="1">MSKGGRGRGWLNINKNQNNPVPPGNIVTVAKPNIPSVADESLFTDASEYKEIINRVKELNISDDGIKFNQKLRYILENWKQDCKSSEEVEKSFDALYQGCLSDDELASKLVIMISSRSFISQEVHDQNFRLLFLRKLQNDFEGGKVLQKTNPIAFRNCVRMLGEFFSKARLVNGDPFTFMLIPLVNCLEMLLDSPQVSDLQQVAFQFYLNGAAIKTECPDKLNELFNKIRTLLTSDKQISKEGKLWLLLSIELGANKFGVLPIDVFKFYQEQIGGNGMSLFQCSQNILSVQTPEDNKTLENYKSSVNVLQLSTKPEPTQPALEPTVPQVTNSVTNFTPEVVNHTPKEPPKTQNSSNNTGKFGRPILGAGARLNKAKFNNDSSNWRDKDNSSTGGWKKTGWGNNDKNSKGKSKGWEHDDRFENNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8I3</accession>
    <name>A0A6P7F8I3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MOB kinase activator-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114327639</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOB1/phocein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132109.1">
        <property type="nucleotide sequence ID" value="XM_028276308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518337.1">
        <property type="nucleotide sequence ID" value="XM_050662380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8I3"/>
    <dbReference type="FunCoup" id="A0A6P7F8I3">
        <property type="interactions" value="952"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662380.1">
        <property type="protein sequence ID" value="XP_050518337.1"/>
        <property type="gene ID" value="LOC114327639"/>
    </dbReference>
    <dbReference type="GeneID" id="114327639"/>
    <dbReference type="KEGG" id="dvv:114327639"/>
    <dbReference type="CTD" id="25843"/>
    <dbReference type="InParanoid" id="A0A6P7F8I3"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000002">
        <property type="entry name" value="MOB-like protein phocein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028132109.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26111" checksum="8430DD1B54B51316" modified="2020-12-02" version="1">MSKMKMADGSTILRRNRPGTKAKDFSHWPDEPFEDMDSTLAVQQYIQQLIRRDPNNIDLILKMPESQDEGVWKYEHLRQFCMELNGLAVRLQGECHPETCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRVYRIFSHAYYHHRSIFDEFETETCLCKRFTQFVTKYNLMSKDNLIVPILEEENTPGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDH4</accession>
    <name>A0A6P7FDH4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fatty acid synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327110</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131415.1">
        <property type="nucleotide sequence ID" value="XM_028275614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDH4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275614.2">
        <property type="protein sequence ID" value="XP_028131415.1"/>
        <property type="gene ID" value="LOC114327110"/>
    </dbReference>
    <dbReference type="GeneID" id="114327110"/>
    <dbReference type="KEGG" id="dvv:114327110"/>
    <dbReference type="InParanoid" id="A0A6P7FDH4"/>
    <dbReference type="OrthoDB" id="6762744at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="10">
        <location>
            <begin position="124"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131415.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="79409" checksum="D8C4ADCC038119B7" modified="2020-12-02" version="1">MSTTILNNAASKLQESDRKSTYKQDNKENSVNAQETNYFHEKSSIIFPKVPRLVAVSGTTKEDVEHLISRIEKNRHDGQFLSSINHTYYDPIKSGHVYRGYVLLCETFHKEIFAAKSLNRPKLVFVYPGLGIELGIAAKSMLKLDIFKDSIMRSANYLEPYGIKLINLIKYGTRDDFGNILNSLVMLVAVQIALTDVLKHIGIEPDIIFGHSLGEVSCGYADGALTAKQAVLTAYGMGRGLLDSNTPLGAMAAVSLPADVIERKCPPNVYPVCFNTTDKTTIAGEPENIEKCVRELQQENIFAKVLPTFGYGFHSKYLDNARPLLVANIQKIIPHPKKRSPKWLSTSILERDWASSLAQTCSAEYYVNAVCREVYFYQIFKKLPDNIVTVEICPTGTLQFIIKSNLGPKVPHISLMKKGSIDSLDNFLCSLGKIHNVGGAPRLENIYTPVHQKTKEAHTCIEILHTINFCQNVQQKDATNDGIMYSAAAYLVLIWKILAELKHDEFEHTDILMENIKFNSAPIARKHLSLLININKETGDLKILKGDLLILTGKVLMMQDSNQNISDKSLDHSRNKEITRLSPSSKFNSHLLNSKYELIDCNNEDVDNLNENRKYTFEWNHNWISFIDSMIRIFTAHKPGNTLFPQKIDKCCFSPQTLLTIVNKSIGNAKIPVNKFGPNIKSPGIEITGIKFGLLKELRTSYKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEI5</accession>
    <name>A0A6P7FEI5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114329502</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028134434.1">
        <property type="nucleotide sequence ID" value="XM_028278633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEI5"/>
    <dbReference type="FunCoup" id="A0A6P7FEI5">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278633.2">
        <property type="protein sequence ID" value="XP_028134434.1"/>
        <property type="gene ID" value="LOC114329502"/>
    </dbReference>
    <dbReference type="GeneID" id="114329502"/>
    <dbReference type="KEGG" id="dvv:114329502"/>
    <dbReference type="InParanoid" id="A0A6P7FEI5"/>
    <dbReference type="OrthoDB" id="7863416at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="110"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028134434.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40393" checksum="6119DCE15FBE53EE" modified="2020-12-02" version="1">MAMSPSHGAATLSKPLSLLLKTLSPAQRCEMIAIIVGGHIQQTASIDKRRNVSSAMGTPTTTTSSIVLLLLLFALPMVLQVLGSMSTLRQECGRSVRRSRQPRAEVLGRIINGKQSIRGAWPWQVSLQLLHPQFGFLGHWCGGVMISSEWLLTAAHCINNDLFNLPLAALWTAVVGEWDREVEEYSEQRIPVEEVILHERFHNFQHDIALMKLSRPVKFTKESRVRAVCLPSTRLLSNQTDLCYATGWGRASEDGMLSIRLLESRVPVHDNAVCRKKYGHAVHIKSGHLCAGHLDGSSGTCVGDSGGPLQCAMQDGRWILAGITSFGSGCAKPGFPDVYTRLSYYLPWIKSKTRSLRRTGRERKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG42</accession>
    <name>A0A6P7FG42_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC114329938</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17 18 19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
            <location evidence="1 12">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135022.1">
        <property type="nucleotide sequence ID" value="XM_028279221.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135023.1">
        <property type="nucleotide sequence ID" value="XM_028279222.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135024.1">
        <property type="nucleotide sequence ID" value="XM_028279223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG42"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279221.2">
        <property type="protein sequence ID" value="XP_028135022.1"/>
        <property type="gene ID" value="LOC114329938"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279222.2">
        <property type="protein sequence ID" value="XP_028135023.1"/>
        <property type="gene ID" value="LOC114329938"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279223.2">
        <property type="protein sequence ID" value="XP_028135024.1"/>
        <property type="gene ID" value="LOC114329938"/>
    </dbReference>
    <dbReference type="GeneID" id="114329938"/>
    <dbReference type="KEGG" id="dvv:114329938"/>
    <dbReference type="CTD" id="39445"/>
    <dbReference type="OrthoDB" id="413723at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000003">
        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028135022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028135023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028135024.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64145" checksum="9D668F8BA33A7FE9" modified="2020-12-02" version="1">MSKTINAYRIKKIENYGKMTQMTQEEIVAAVKTVAQGLEALRSEHTGILHSLHEAPDPVVSERAGLVQQSADMIELGLGEAQVIMALAAHLQLVEAEKQKLRTQVRRLCQENAWLRDELASTQQRLQSSEQMVAQLEEDKRHLEFMSSVSKYDQDVNEDNASEQSKSEKPDPVVDLFPDDDADDRHNMSPTPPNQLQLSQQVNAGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAANLLNDALAIREKTLGENHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALDIREKVLGKEHPDVAKQLNNLALLCQNQGKYEEVEKYYQRALEIYEKRLGADDPNVSKTMNNLASCYLKQGKYKEAEVLYKQILNRAHEREFGTIDGENKPIWQVAEEREENKAKNKENVPYGEYGGWHKAAKVDSPTVTTTLKNLGALYRRQGKYEAAETLEDCALRSRKEALDIVKHSRNLLTDDRRKPGSAKDKNSRRGSRESLDMTYDGDETSTAKTPDTEKSGLKTKLFSALGIHSPVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FM19</accession>
    <name>A0A6P7FM19_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">DNAation factor subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC114331810</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6 7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137278.1">
        <property type="nucleotide sequence ID" value="XM_028281477.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028137279.1">
        <property type="nucleotide sequence ID" value="XM_028281478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FM19"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281477.2">
        <property type="protein sequence ID" value="XP_028137278.1"/>
        <property type="gene ID" value="LOC114331810"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281478.2">
        <property type="protein sequence ID" value="XP_028137279.1"/>
        <property type="gene ID" value="LOC114331810"/>
    </dbReference>
    <dbReference type="GeneID" id="114331810"/>
    <dbReference type="KEGG" id="dvv:114331810"/>
    <dbReference type="CTD" id="34734"/>
    <dbReference type="OrthoDB" id="9943677at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039729">
        <property type="entry name" value="DFF40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015311">
        <property type="entry name" value="DFF40_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13067">
        <property type="entry name" value="CASPASE-ACTIVATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13067:SF2">
        <property type="entry name" value="CASPASE-ACTIVATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09230">
        <property type="entry name" value="DFF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028137278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028137279.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40976" checksum="FD4C4235719576E1" modified="2020-12-02" version="1">MTTTKGFKVTDADRKTRVGIAVKNLEELKKKTIDKFKLKFSPGEIDFQTTDGTIIENEEYFQTLPPQTLLIWVKAGEKAATDAEILYKTIREVNDEYLTAGEKVQEFFTEKMKSKVLKLAEVLKGLDADKAKLSNRSEHPEWFEGLSTTAKTKEDYMFRRAQDRIRSYYYRTKDELGNRKDVPQSAVRDLFLELEARLKLNKYHGYYFNRANSGNNDDMKSICDRQGMFRCQGRWDKEQCLYSPTHSINPYLSRESRIIFQTWNLDHNKERSRSVIPAVCAALRTSHPAAAHAEIRRIHVDLDLTKKGKYRNVCLDIKGIYNDLFTLNNLKFVHIVCHDKGAHVSAKAGPYLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMF0</accession>
    <name>A0A6P7FMF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC114330841</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in muscle cell metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136057.1">
        <property type="nucleotide sequence ID" value="XM_028280256.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136058.1">
        <property type="nucleotide sequence ID" value="XM_028280257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280257.2">
        <property type="protein sequence ID" value="XP_028136058.1"/>
        <property type="gene ID" value="LOC114330841"/>
    </dbReference>
    <dbReference type="GeneID" id="114330841"/>
    <dbReference type="KEGG" id="dvv:114330841"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000020">
        <property type="entry name" value="Cytochrome b5-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053100">
        <property type="entry name" value="Cytochrome_b5-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740:SF1">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028136057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028136058.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="56614" checksum="D4C4199B9DAF7751" modified="2020-12-02" version="1">MQLSPHCTLYILSIILNTILSIIRTWSALTNWQENKRDFPSNSTIRRQKMSPNPDFVPISSLGIKPIPSRGKGRVVTTNMWLKEKQIDDGAEGLWRVHDKIYDLTEFVHKHPGGSDWLTLTKGTDITEAFEVHHLTEFPNEILKKYFVKNATTERNSPYTFEEDGFYRILKKKIQPVLRNCPKESYTKSKLITDSLLVLSFLFSIFAVKFWSFGLGAFGGVFLGMVTIAAHNYLHMKDNFRIYYFQFSFLQVRESRISHALSHHLYTNTITDLEIAMFEPLLNYLPVEKKPMQKVVSVMLVPIICLTFFHKPAIERIINLPTQYKQLRFTDLLGLLLPICMYVFGNDDLLSVFIMWNFVLVCGGTYMSFVGFNAGHHHPDVFHDGDTPRGKKFDWGLGQLEALLERKEITGSHFLVLTSFGDHALHHFFPTLDHGQLQHLYPVFKEVCNQFNVDLRMVSQIETIKGNFQQLVRVEPNPNPTDLLKYSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNQ1</accession>
    <name>A0A6P7FNQ1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ceramide synthase 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114332390</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137979.1">
        <property type="nucleotide sequence ID" value="XM_028282178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNQ1"/>
    <dbReference type="FunCoup" id="A0A6P7FNQ1">
        <property type="interactions" value="2555"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282178.2">
        <property type="protein sequence ID" value="XP_028137979.1"/>
        <property type="gene ID" value="LOC114332390"/>
    </dbReference>
    <dbReference type="GeneID" id="114332390"/>
    <dbReference type="KEGG" id="dvv:114332390"/>
    <dbReference type="InParanoid" id="A0A6P7FNQ1"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="17">
        <location>
            <begin position="135"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028137979.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="42768" checksum="1EA47DBD33A8DC4F" modified="2020-12-02" version="1">MAYYYRTFMETFWCEHVWLPPNTTWKDIAPDADPNVRHADPKHLFYPLPMAFVLLFLRYILEKYWFAPVGVSLGIKNNRPKKTPDNPVLEKAYTQSKKWKHKQVQGLAKQLDISERQVERWLRLRKAQNKPSTLVKFCENSWRCLYYTLSFIYGLTILWDKPWLWNINECWTGFPHQDVTNDIWWYYMISMSFYWSLSVSQFFDVKRKDFWQMFIHHIATIVLMCLSWIVNVFRIGSLVLVVHDCADIFLEAAKMAKYSGYQKICDIIFAVFTVLWIVTRIGIFPFWIIRNTSIDAPKIVPMFPAYYIFNGLLILLLFLHCFWTYLILKIVHNSLNAGQMEGDIRSSSDEYSEDSNKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPW7</accession>
    <name>A0A6P7FPW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC114331431</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028136812.1">
        <property type="nucleotide sequence ID" value="XM_028281011.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136813.1">
        <property type="nucleotide sequence ID" value="XM_028281012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPW7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281011.2">
        <property type="protein sequence ID" value="XP_028136812.1"/>
        <property type="gene ID" value="LOC114331431"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281012.2">
        <property type="protein sequence ID" value="XP_028136813.1"/>
        <property type="gene ID" value="LOC114331431"/>
    </dbReference>
    <dbReference type="GeneID" id="114331431"/>
    <dbReference type="KEGG" id="dvv:114331431"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="11">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="11">
        <location>
            <begin position="326"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028136812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028136813.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="58049" checksum="72D52562404B37C1" modified="2020-12-02" version="1">MTSSLPIPADVLKTLVCIRCRNYLSVFPTYTKNDGTGAVCGRCKIGEDDMFVRDEAYESIAQFFPFACRFAKSGCKDNLVPAILEQHELFCEFRMFDCPSKNYSNCTWTGPRTDIVKHFSTDHSTLLLKEPSFEINFLCSIEECLLLPFGNEVFNVKKEVDARKGVFSCSVEHINVTEKSDTFNYFLRIVSGNKNFFFTCAQKNTSSEQRLNTTHLTIENVKQKLQDPDSVTVTIEIVKAEEPTTKVEEIPIEEKADIKQNPNIIWALLANLECPVCLDYMLPPIYQCANGHSYCEPCKKKVEICGLCKVPVHDTRNFTLEKMTEHLTYPCKYHKAGCTYSCISTEIRDHETCCEFGPFICPLKDTTNCDWQGSHSRVLDHIDNNHNEVVLKSDQVTIPFNKKDTKSCYVIKYDKKIFQFDYKYDEQKLYLSVRIIGRSTDAKEYRFEADVIDLGGLKRKCFNVGLVSAISSADERFKDGKCVKIYLEQIIGFYSDTINLRIRIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSK8</accession>
    <name>A0A6P7FSK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114333654</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028139389.1">
        <property type="nucleotide sequence ID" value="XM_028283588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSK8"/>
    <dbReference type="FunCoup" id="A0A6P7FSK8">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283588.2">
        <property type="protein sequence ID" value="XP_028139389.1"/>
        <property type="gene ID" value="LOC114333654"/>
    </dbReference>
    <dbReference type="GeneID" id="114333654"/>
    <dbReference type="KEGG" id="dvv:114333654"/>
    <dbReference type="InParanoid" id="A0A6P7FSK8"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028139389.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28886" checksum="4D130025C902A6D5" modified="2020-12-02" version="1">MAENSTVRLPQKRFYRQRAHSNPIADHCFDYPHAPELMDWSPFYPEKFVDNENNPQKIEFADIGCGYGGLLITLSPMFPQTLMLGMEIRVKVSDYVMDRITALRSQHPTEYQNVACLRSNAMKYLPNFFKKGQLQKMFFLYPDPHFKKAKHKWRIINQNLLAEYAYVLSEGGIVYTVTDVKDLYEWMCHHFTMHPLFEQILEEDLKGDPIIEKLYSSTEEGQKVTRNNGDKFLAVFRRIQDPLCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSS3</accession>
    <name>A0A6P7FSS3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kazrin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114330643</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135845.1">
        <property type="nucleotide sequence ID" value="XM_028280044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSS3"/>
    <dbReference type="FunCoup" id="A0A6P7FSS3">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280044.2">
        <property type="protein sequence ID" value="XP_028135845.1"/>
        <property type="gene ID" value="LOC114330643"/>
    </dbReference>
    <dbReference type="GeneID" id="114330643"/>
    <dbReference type="KEGG" id="dvv:114330643"/>
    <dbReference type="InParanoid" id="A0A6P7FSS3"/>
    <dbReference type="OrthoDB" id="6430345at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09570">
        <property type="entry name" value="SAM_kazrin_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037614">
        <property type="entry name" value="Kazrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059089">
        <property type="entry name" value="Kazrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037616">
        <property type="entry name" value="Kazrin_SAM_rpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF1">
        <property type="entry name" value="KAZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25986">
        <property type="entry name" value="Kazrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="614"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="704"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028135845.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="102179" checksum="98994AE52A208DB6" modified="2020-12-02" version="1">MALLMRRLFVDAQAKLRRMVEEHSTDLTSRIESDYPNSSPAAIPSPACTAHEAKVVETLPVASISPLDVNFLKPTLGEDKVIDCDVDLKYSNDNKKNNKSNRPNYIETKRSKSLSVEGPEDISKKDIKKTRSNPLKSEDSSADNEKIIDDTKEVEMTVEENIATVLKGSRSSLETRSDSPKPGCSSQPDIADSSSPRSPRSSDGNRDDLSALLPSPSNYPKSSATIRRLRQENERLQAEVTRLKRLVVSGATSALAERKNLSEKADPNSATHALELELELAREALSTLKADKRRLKAEKFDLLNQMKQLYLTLEDKEKELRDFIRSYGQRTRDNETSMQQLSTEREERERERWSLLRHARDEAERSLSLAAQLNAKELQLQQAQEQLQEARRQLASSGCLSDQESLASLPRHNINGGALTPGSGGLLSGHHGLGQLPGDRGSCSADSGVRVSSDRESGATSVAGNLSDSTTDGTPTITLGEGHKDMDSVSLISSVPPPHMYQSSTKDCSPTLSPLNANNFSRSVEQLSSPMEPEPITVGRRNKQSVRPSSGRGGTWGSISRVFARSRHRNKSNSLQETSESYDPYRSWSPLTEEGYAEKLRLLREANSIPMERWRASTVLAWLEIALGMSQYGARCAENIKSGKIGPLHGQVLLELSDLELECGLGITHPMHRKKIRLAIEEHRNPALVRYPCIAQLGHTWVCSEWLPDLGLSQYCENFATNMVDARMLEHLSKKELEKYLGVTRKFHQASIVHGIHLLRIMKYDRQALAVRRHQCETMDADPLVWTNQRFIRWARSIDLAEYADNLKDSGVHGGLVVLEPSFNGDTMATALGIPASKNIIRRHLTAELDALILPARSTLEHYVRVRAKSRVLGGSLGRTFSRSCGGLAGTSTANRDSFGGKEQHKSSSIRIYNGRRPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTF0</accession>
    <name>A0A6P7FTF0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sialin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114330839</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136055.1">
        <property type="nucleotide sequence ID" value="XM_028280254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTF0"/>
    <dbReference type="FunCoup" id="A0A6P7FTF0">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280254.1">
        <property type="protein sequence ID" value="XP_028136055.1"/>
        <property type="gene ID" value="LOC114330839"/>
    </dbReference>
    <dbReference type="GeneID" id="114330839"/>
    <dbReference type="KEGG" id="dvv:114330839"/>
    <dbReference type="CTD" id="32263"/>
    <dbReference type="InParanoid" id="A0A6P7FTF0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000445">
        <property type="entry name" value="putative inorganic phosphate cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028136055.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="56082" checksum="7E0A0B29E41D8F14" modified="2020-12-02" version="1">MYVPKENPESNGEESDTESVYEDEDETTRILPPEVEDTTNCMKARHILGILGFLGFANVYAMRVNLSVAIVAMVNTTQPVFTNNSYDHCPITDNSTNTNGTATPGEFDWDEKTQSIVLGSFFYGYVLTQVPGGRLAEIFGSKRVYGIGVLVTSIFTLLTPIAARMNFTLFIIVRVLEGMGEGVTFPSMHAMLARWIPPLERSKFAAYVYAGTNFGTILSLPISGWLCSLKLDNGWPLSFYIFGVLGIVWYLFWVLLIYDTPMSHPRIDPQEKAFILASIGPQDDRDTSSIPWKHMLRCMPLWAILVTQCGQSWAFYTQLTELPTYMAQILHFDIQSDALLSAVPYFTSWIGGILFSIFADWLLSKGYLSLSTSYKVFNSVASVIPSIGLLGVAYVGCDKVAAQLLLALTATFGGAVYAGNQMNHIALSPQYAGTMYGITNSAANMCGFLAPYVIGLIIQGQETLGQWRMVFYLAAGINIGTNLFYIMFASARERSWSRSRRLSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWN2</accession>
    <name>A0A6P7FWN2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peroxidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114334909</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028140846.1">
        <property type="nucleotide sequence ID" value="XM_028285045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285045.2">
        <property type="protein sequence ID" value="XP_028140846.1"/>
        <property type="gene ID" value="LOC114334909"/>
    </dbReference>
    <dbReference type="GeneID" id="114334909"/>
    <dbReference type="KEGG" id="dvv:114334909"/>
    <dbReference type="InParanoid" id="A0A6P7FWN2"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF86">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027664495" evidence="9">
        <location>
            <begin position="18"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028140846.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="69282" checksum="62574659BDF603F9" modified="2020-12-02" version="1">MYYLHGILLIILNCVQGDRECGLDYVHCECLDFTYRSIDGSCNNLDHPNWGTQYSVYDRLIPARYGNNNSIALCGNGEPLPNARCVSTVIFSDETYPDPELTAYAAQYGQIIAHDMGQNFLIGNGDPLSCCNTWLGHWDEPPDGCISITVPDDDYHYSDLNCTCMSVLRTTTNRQLGCSMYLHDTAQLSAVTAYLDLSLIYGNTEDVCLKLRTLEGGLLKLEMRKQREWFPDSTERDVFCPLLNENEVCYHTGDPRVDQNPPLTITHLLWAREHNRVARALHHLNPHWDDEAIFQAARTIVIAEYQHIAYYELLPYYMGEYNLLERGILYYTDEFVDDYNASVRPHVYNEHSQAAFRHFHSLVPGMLSLVDASGCPYRSIVMRDHINRPGVLEKGDYLDSIIRGMVTQPSLSPDAYCDPEMTNYFFPMYLKPGLDVRAVDIQRSREHGLGSYNDMREYCGLGRIHSLYDLLDFMEIEDAEKLISLYNHPDDIELIVGGSLERRVHGTLAGPTFLCIMFEQFYRTRVADRFFFENHYTGFSRAQLREIRKSSIARLICDNANHIIEIQRHAFEQVSHSNPKVACNKIPGIDLTLWEERYTNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWZ2</accession>
    <name>A0A6P7FWZ2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein NipSnap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114331908</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137398.1">
        <property type="nucleotide sequence ID" value="XM_028281597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWZ2"/>
    <dbReference type="FunCoup" id="A0A6P7FWZ2">
        <property type="interactions" value="1328"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648466.1">
        <property type="protein sequence ID" value="XP_050504423.1"/>
        <property type="gene ID" value="LOC114332940"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FWZ2"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000046">
        <property type="entry name" value="Nipsnap, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000003">
        <property type="entry name" value="Protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028137398.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="31758" checksum="757C03E50A236C48" modified="2020-12-02" version="1">MANLFKFFNKLPPNFRSVSTTTTKNDAWLSKIFVRKIEPTKESHSRMLSDKEIIYSLQTHNYRPDSKVAYLQNVKNKVDYIKAQDSLSKEVELVGSWTVNVGDQDQALHLWKFTGGFDMIDRYNDFTGKNQEFQRLNEEQGKLVRSRHLQYLLAFSYWPQILMRQPKNIYEIRSYALKPGTMIEWGNNWARAINYRQNNDEAFAGFFSQIGRLYNVHHIWCYSSLNGRKETRESAWRSPGWDECVAYTVPLIREMHCRIMVPTEFSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYS6</accession>
    <name>A0A6P7FYS6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114335606 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114335606</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141666.1">
        <property type="nucleotide sequence ID" value="XM_028285865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYS6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285865.2">
        <property type="protein sequence ID" value="XP_028141666.1"/>
        <property type="gene ID" value="LOC114335606"/>
    </dbReference>
    <dbReference type="GeneID" id="114335606"/>
    <dbReference type="KEGG" id="dvv:114335606"/>
    <dbReference type="InParanoid" id="A0A6P7FYS6"/>
    <dbReference type="OrthoDB" id="9425590at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000072">
        <property type="entry name" value="CLIP-domain serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF28">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE 11C ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028025823" evidence="4">
        <location>
            <begin position="21"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="622"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141666.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="96204" checksum="6560BFF583D477F6" modified="2020-12-02" version="1">MNWIHSSLLALVMSIFLIQASDPPYEKPTGGFIKFYPLKTPALIFTPFVTNIKKMEDDTKKISDRQFLSTDLQPPTLDPQELHPPTVDPQSMLPPPVNTFTEISSPPVNTFTETSQSDFLPPVAIYSTLQDFPTTGSQNTNISEATAQNNLDNNLNLPLYPPIHPAPFDNPNEGPPNNYTQEQPYNTNDATQPSFSGHPGTAANANDEGLTRLHNYLRQINNESQSNTNEGFHNKGKSSYEALLEQDFIRPLLKLYEKEIHLDENYAIGNGSRISKEDYLESFKPDKNTEKVVPEDITNNRETAIVQVKEQVQQDLSVQNEVKFEQQEVALPHKEEKMVKMVNDIFTKPIRRDDFNVAENKDKEHIGEILPADFYRKISNNNRIFQNRRLTHIMPFKPNLVTPVERSEILRIPVVFPSGPSSEGIDGIVTDNANRVNEQYYARTPRLSLPLVEHFRVPRRYKGFRDNYSEGQIYFDPSARYQTAWTASSRRPRVIFPTEQVAFRDPVQNQEVEPDWLAGDSNLQDLQEQDIRDRGSEVFCAPGATCEFFLSCWLSGGLLDQPCGGLLKGCCYRGRVAKTGPSGLLAIGTLDAPVETPKVQQFAVVDNDNRCGVSSPQAQRRIVGGEEAGFGTFPWQAYIRIGSSRCGGSLVSRRHVVTAGHCVARATPRQVHVTLGDYVINSAVEPLPAYTFGVSTIQVHPFFKFTPQADRFDVAVLRLDRAAHNLPHITPICLPPRGENFLGEIGVAAGWGALSPGSRLRPQTLQAVQVPVIENKQCERWHRSKGISVTIYEEMMCAGYKNGGRDSCQGDSGGPLMLQRTGRWFLIGIVSAGYSCAQPGQPGIYHRVAHTVDWITRAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G356</accession>
    <name>A0A6P7G356_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dynein light chain Tctex-type-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114333705</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139453.1">
        <property type="nucleotide sequence ID" value="XM_028283652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G356"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644364.1">
        <property type="protein sequence ID" value="XP_050500321.1"/>
        <property type="gene ID" value="LOC126880488"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G356"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028139453.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12136" checksum="1976D706494D0F1C" modified="2020-12-02" version="1">MDDEENQFVAEDVSKLVKDTIENVLSEATYIPEKVNQWSASVSEQCLSALSKTKKMFKYVITCSIMQKTGAGLHTASSCYWDSATDGTCTVRWENNTMYCVVTVFGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7D6</accession>
    <name>A0A6P7G7D6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 4C1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114338629</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145026.1">
        <property type="nucleotide sequence ID" value="XM_028289225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7D6"/>
    <dbReference type="FunCoup" id="A0A6P7G7D6">
        <property type="interactions" value="103"/>
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    <dbReference type="EnsemblMetazoa" id="XM_028289225.2">
        <property type="protein sequence ID" value="XP_028145026.1"/>
        <property type="gene ID" value="LOC114338629"/>
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    <dbReference type="GeneID" id="114338629"/>
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    <dbReference type="InParanoid" id="A0A6P7G7D6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd20628">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028145026.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="57041" checksum="10B3C9006EE94C05" modified="2020-12-02" version="1">MIGFGIIVVLFTAFYFYQQSRRNTKYMRNIPGPKPNIFFGNLLEFAFIPTHKYLDVFLGFIRDYGKLVKVYDGPFSMAMIATDEKFVEHILSSTKYIDKADQYDYMKGWLGEGLLTSTGAKWKKRRRMLTPAFHFSILENFLEVFDTVGDIFIQKLRREVGKKTVEISEPVSLYTLDVICEAAMGIKLNAQTDSTSPYVRSTKSMCYVIVERILSPLDPSLYPLTLNYYREKRALKVLHAYTDSVIDKKISEKKKKTEILVDENTNIGIKKKQAFLDLLLDYSMDGEPLLRTDIREEVDTFMFEGHDTTSSAISFAMFALANHPEVQEKAFMEQKEMFGNFVDAKPTVSQFQDMKYLDLVIKETLRLYPSVPVLGRRLPEDMEYDGNLLPKGMNILLSTFAMHRCEEYFPEPLKFIPERFEDAKLTNPYVYTPFSAGPRNCIGQKFAILEVKSTLSKILRNFELMPATPVHELQLAPETILVSKNGIRISIKERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBH5</accession>
    <name>A0A6P7GBH5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114340055</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340055</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
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            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="XM_028290773.2">
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        <property type="gene ID" value="LOC114340055"/>
    </dbReference>
    <dbReference type="GeneID" id="114340055"/>
    <dbReference type="KEGG" id="dvv:114340055"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHK_kinase-like"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="124"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028146574.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46983" checksum="B16B6EB3B4169AF8" modified="2020-12-02" version="1">MKMSSEDKTKQALHWILESIGTSNLKVNFKTREDNLEGFMADTLLAEVILQNGEVLYLFIKIGRMNLKSKAPIVTDCSKREIYFYRNVVSSYQRFLQEKNLSEKDFLSIPKCYKTFLSDTEEVIVLEDIKPKGYQLFNRHLPMNLSHIKMVLTSLAKLHSISFALKAQKQDEFAKLTENYSSLLGKNMDFYRDSFNNRLDKLIEKLQFYHKNIQADKVKKLKKSDIIDILQRIINDNPQEAIVLHGDSHNNNFLFQYKDSNTEHPSKLIMVDFQLSFLHSPVIDLSYFWHFVASTQEYPHLTELLEFYHKELSTNLNLLGCNSDELFSLDTLWTHWKKYSLYGFIQAVLFTYLLYVDHEDLQKINDGSQGTKVQKLVGVQLKNDEAYVQRISALIDYYKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GC18</accession>
    <name>A0A6P7GC18_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114340300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114340300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146839.1">
        <property type="nucleotide sequence ID" value="XM_028291038.1"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="XM_050650749.1">
        <property type="protein sequence ID" value="XP_050506706.1"/>
        <property type="gene ID" value="LOC126884677"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GC18"/>
    <dbReference type="OrthoDB" id="10367519at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027655597" evidence="2">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028146839.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="16126" checksum="C152A988FAD4E978" modified="2020-12-02" version="1">MNSYGLLCFVLILGVISQESWAETAYSSSGEVLGARRGESRSDEVGLRRLRPIPGLRPIPMIKDTGFSAENNVDEDELKDLLGEYGIEFITDEERQKNFEQLQNDMYGEDLEKDEHMKKEDAYQNGEKDLFVKESQRTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEG3</accession>
    <name>A0A6P7GEG3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114337136</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028143333.1">
        <property type="nucleotide sequence ID" value="XM_028287532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEG3"/>
    <dbReference type="FunCoup" id="A0A6P7GEG3">
        <property type="interactions" value="1467"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643528.1">
        <property type="protein sequence ID" value="XP_050499485.1"/>
        <property type="gene ID" value="LOC126880012"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GEG3"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000471">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="498"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028143333.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="74015" checksum="F2BD287CCA594C0B" modified="2020-12-02" version="1">MSESEGVVKNSSDESDKDSDQDVPEDSHKKHKHLQNKDFEERKGKKRSNKEEDNSDEDVAIGPAIPEAEKPKKRKVLPHEQLYLDSLPSAESYERSYMHRDVITHIVVTCTDFIITASCDGHIKFWKKMENGIEFVKHFRSHLGPIVKIACNCEGTLLCSASVDRSLKIFDVVNFDMINMIRLEFVPGTIEWIHGSGEPIHTLAVADKATARIHIYDGKDGKALTVFEKIHTSPVTLIKYNPKYDVVISADKKGMVEYWHGSKHDYGVPKNIGFDSKLDTDLFEFAKNKTVPTGLAFSNDGKKFATISTDRKIRVFNFLKGKLILVLDESLPRFSDHQHKTQQLPNMEFGRRMAVERDLEKSDSFELANIIFDESGYFIMYATLLGIKLVNIHTNRCVKIIGKNENLRMLNIALYQGSAKKSKAAVTLEIEASNNPTLDAILPDPTLICTAYKKSRFYLFSRREPDDLQSDQDRDVFNEKPSKEDSLAAAENPAVQRLYENAILHTVFGDIHIKLFIKDTPKTVENFCVHSKNGYYNGHIFHRVIKGFMIQTGDPTGNGTGGESIWGGEFEDELRPHLKHDRPYTVSMANAGPNTNGSQFFITLTPTPWLDNKHTVFGRVVKGMEVVQNISNVKTNVKTDKPYDDIRIVSVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHX1</accession>
    <name>A0A6P7GHX1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC114338370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114338370</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144758.1">
        <property type="nucleotide sequence ID" value="XM_028288957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHX1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653096.1">
        <property type="protein sequence ID" value="XP_050509053.1"/>
        <property type="gene ID" value="LOC126886232"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GHX1"/>
    <dbReference type="OrthoDB" id="6770110at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028144758.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="20315" checksum="6F1B139E96F0E584" modified="2020-12-02" version="1">MTLPSRDNAASRLIVKLKNIRKLHYQLCTVGKNINSHFSLQLLLIIGVTFVEFVNHVHKFIGNFTDDIDSSSIFNYNTLLLVMLPLKIWDVIAICVLCSYTKYEVNLTGDILFNIHNKYDLTISKEIQIFSRQILQWKFKFTAFDFIDIDTSLICEIIATAATYLTIIIQFDSKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GRV1</accession>
    <name>A0A6P7GRV1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipid phosphatase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114345661</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152259.1">
        <property type="nucleotide sequence ID" value="XM_028296458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GRV1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028296458.2">
        <property type="protein sequence ID" value="XP_028152259.1"/>
        <property type="gene ID" value="LOC114345661"/>
    </dbReference>
    <dbReference type="GeneID" id="114345661"/>
    <dbReference type="KEGG" id="dvv:114345661"/>
    <dbReference type="InParanoid" id="A0A6P7GRV1"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028152259.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33360" checksum="04E83033072CE0D6" modified="2020-12-02" version="1">MGVILSTLGIQEPKLSLRPQKVVVGTIHGTQITLAYVLNTFVSIFAVLMIVLLEFGTIPAVQQGFYCGDPLISHKYTGDTITPVTLGLTAPLLVIVMVLVTELLAHQSIKQINLHAVAFYVSESSVGATLTLLVTSIGKVLVGEHRPHFLDTCEPDTAKNCSIGTFIETYTCTSTEFEPSFLVDSSLSFPSGHSSIAWFIGIFSAYVVHVRMTTVNSGYIMRPFLISVCLTWSMVCSLSRITDRRHHWWDVLAGSVLGIVFAVYTIKVLHEKIKENNVPICNICLEREVPLNGNGVNTNLSFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSW0</accession>
    <name>A0A6P7GSW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regulator of nonsense transcripts 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Up-frameshift suppressor 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114340362</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146900.1">
        <property type="nucleotide sequence ID" value="XM_028291099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSW0"/>
    <dbReference type="FunCoup" id="A0A6P7GSW0">
        <property type="interactions" value="2407"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659654.1">
        <property type="protein sequence ID" value="XP_050515611.1"/>
        <property type="gene ID" value="LOC126890588"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GSW0"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000014">
        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000015">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000023">
        <property type="entry name" value="regulator of nonsense transcripts 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="70"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="443"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="647"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="904"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1111"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="276"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="924"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028146900.1"/>
        </source>
    </evidence>
    <sequence length="1130" mass="129260" checksum="056FE6E4002E427E" modified="2020-12-02" version="1">MTINENTEDDPEQVMGSNSDLAESERAVLLTFIQEIQEKLAQKKELRAKNTNASSNRPSDSSFSKLDSSLKKNTAFVKKIKNFSSSCVEGYLKDMAGLNLSKYISEIAAAIVDSKLKMSDAPAAVKLCSVLHQTYADFSQHLFENWQKILTIKVGDKIPNPSKLRVDLRFYADLLQAGIFSNKNALSLLGSVLTTLINMDKEEHFNIAIILSFCRHCGDDYAGLVPRKMKEFSTKYNMEIPKSTFLPSEKQQNVRALLKDYYVSLCKHLVKDHIEMQNFERQNMRILQTKGELSQERKEKLEQLQSAYEKLLANTQNYSDILDEDMPTLRTQNLPKGDENMIVTGSGTDLEEGAGNLENIWCDIETQKFYCDLPELTVFLPTAFLNKGQTPPPAETAVTEEVLDSDLPVDELEDDSKAEEPPIAEEEIEDPTSTTASNKIVLEAFLNNLPNCVNREMIDNAAIDFLVTLNNKHNRKKLVRSLFGVNRTRLDLLPFYARFVAILHPAVPEVGSELCQMLRQDFKYHVRKKDQINIESKIKVARFIGELVKFKLYSKIEALYCLKVLLHDFSHHHIEMACNLLEVCGRFLYCSPDSYQRTKVYLEQMMRKKAVMALDSRYVTQIENAYYYVNPPEVVTITKKERPVMHQFIRKLLYQDLQKNNTDKIMRLMRKLDWASPEIAAYAVKCLTGAQNLKYFNIRCLANLLAGLVAYQEEIGTKVVDGVLEDIRLGMEANLPKYNQRRIAQVKYLGELYNYRMVESSDVFKVLYSIISFGVSMDPTEPSPLDPPHNLFRIRLASVLLETCGTYFSSGSSKRKLDYYLAFLQAYYWFKKKMWQEGFPPILEHIFKDTLTTLRPKLKLCQSYDEAIEELNNIKVALGIEKLLEIDHGNVEEDGLDTITETDNEEVAEDETSEGVTGPVTDDTATEDETVDNTQGSDDEGENMTSEAEQDPVSESLAIPKGPKKVDCAEDDEFLNALDKMVSENIQERMKEPVKAGNIDISVPVVLKSNVKRTYEQLQETPDESTQGKIGFVLMVRKGNKQQYKQFEADVDSELAQNLRDQEQAQREEKEKVKRLTLNITERFEEEDYQEMMQQQNKPITQNLNRERKKYQHLKGTPDADLIFGPKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GW83</accession>
    <name>A0A6P7GW83_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Selenide, water dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114347513</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154011.1">
        <property type="nucleotide sequence ID" value="XM_028298210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GW83"/>
    <dbReference type="FunCoup" id="A0A6P7GW83">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298210.2">
        <property type="protein sequence ID" value="XP_028154011.1"/>
        <property type="gene ID" value="LOC114347513"/>
    </dbReference>
    <dbReference type="GeneID" id="114347513"/>
    <dbReference type="KEGG" id="dvv:114347513"/>
    <dbReference type="CTD" id="36587"/>
    <dbReference type="InParanoid" id="A0A6P7GW83"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000006">
        <property type="entry name" value="Selenide water dikinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000010">
        <property type="entry name" value="Selenide, water dikinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256:SF0">
        <property type="entry name" value="INACTIVE SELENIDE, WATER DIKINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="SELENIDE, WATER DIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="6">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="7">
        <location>
            <begin position="223"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028154011.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="44608" checksum="FE836BDBCA48AE6A" modified="2020-12-02" version="1">MGDYQVTQVQQDALGAVQLELGGNPNTLALRRPFDPLAHDLEASFRLTRFADLKGRGCKVPQEVLNKLVEGLQQDYNSAEHEHAHFMHMAIPRIGIGLDCSVTPLRHGGLCLVQTTDFFYPLVDDPYMMGKIACANVLSDLYAMGVTECDNMLMLLGVSTKMTEKERDVVIPLIMRGFKDSALEAGTTVTGGQTVVNPWCTIGGVATTVCQPNEYIVPDNAVVGDVLVLTKPLGTQVAVNAHQWLDQPERWNRIKLVVSEEDVRKAYHRAMDSMARLNRIASRLMHKYNAHGATDITGFGLLGHAQTLASHQKNEVSFVIHNLPVIAKMAAVAKACGNMFQLLQGHSAETSGGLLICLPREQAAAYCKDIEKQEGYQAWIIGIVEKGNRTARIIDKPRVIEVPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H247</accession>
    <name>A0A6P7H247_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114349420</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155594.1">
        <property type="nucleotide sequence ID" value="XM_028299793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H247"/>
    <dbReference type="EnsemblMetazoa" id="XM_028299793.2">
        <property type="protein sequence ID" value="XP_028155594.1"/>
        <property type="gene ID" value="LOC114349420"/>
    </dbReference>
    <dbReference type="GeneID" id="114349420"/>
    <dbReference type="KEGG" id="dvv:114349420"/>
    <dbReference type="InParanoid" id="A0A6P7H247"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007309">
        <property type="term" value="P:oocyte axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052139">
        <property type="entry name" value="Methylosome_Comp_WDR77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853:SF1">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028155594.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37079" checksum="C126B118F5DD1A8E" modified="2020-12-02" version="1">MLDQVQEPNAFIRKRTTLPNAPLEPRNHFSKTPVIYDHLFFVNFNKAGHSILGASAITDSFWEGTLLYFKDEDQLENFDYHGSYVYGTTSDGKFIDDRTIALAEDSGHINILSIDEDATLRTTNYFWLSERVPEIGVWENSGKILGCAGRTVYIYDANSTNGKPIERYDSYHCDTVSSVDTLKDNTNVFLSGGRDRMACIWDMRNSVAASLLYSNEFSAINSVSWNQSDTNYIAVGTQAGDIYLLDKREPKDFVSVISCFSSPVNRLCFNNSNLAVCGDSKDVLVVNTQSNSMNVIYKNEEHKGHVKGLSWNGDVLFSCGFERSLIKHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6P3</accession>
    <name>A0A6P7H6P3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ethylmalonyl-CoA decarboxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114347758</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154227.1">
        <property type="nucleotide sequence ID" value="XM_028298426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6P3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654928.1">
        <property type="protein sequence ID" value="XP_050510885.1"/>
        <property type="gene ID" value="LOC126887417"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H6P3"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028154227.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30772" checksum="69B55A8FF2B3E2AD" modified="2020-12-02" version="1">MATSPELCYMGKFLEKYDGGKIYLKKDYWNEGIALVCIEHLEKRNAISGKMYVDFMKCVQELENWKNGKAFILYGEGTNFCAGGDLDFAKKESNSTAGYYMSYYMHHVLKKIRKLPLISVSLVHGATVGGGAEISTFCDYILVSDNTKLGFVQGRMGITTAWGGGTRLVQIVGQRKALEFLASGKVFNAQECLKLDLAYKIVSAEQRLEQALDFVRGLTAFHSTITQSMKLVTEVASEESLEKSLDFERNEFYTKWGSDINKEAVSKNIKFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HA34</accession>
    <name>A0A6P7HA34_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC114349365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114349365</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155517.1">
        <property type="nucleotide sequence ID" value="XM_028299716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HA34"/>
    <dbReference type="EnsemblMetazoa" id="XM_028299716.2">
        <property type="protein sequence ID" value="XP_028155517.1"/>
        <property type="gene ID" value="LOC114349365"/>
    </dbReference>
    <dbReference type="GeneID" id="114349365"/>
    <dbReference type="KEGG" id="dvv:114349365"/>
    <dbReference type="InParanoid" id="A0A6P7HA34"/>
    <dbReference type="OrthoDB" id="6409105at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF3">
        <property type="entry name" value="NIDOGEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028189706" evidence="6">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028155517.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44110" checksum="523549913D766C06" modified="2020-12-02" version="1">MKILLFMLVFLFCRQECTDTCNDILVTDFSIDDCIHQQTLTSSYFYTVDTKTCLPGCQLYADAGYLRKNCPPDCPPGYMCAKRCSASNAAVKVTCKVDADCKAFPWSRCQNTCVPDLNSCMAYHANTSDFRYNKFTAIKFKPACQVDGYWKAKQCKGGVSGRCMCFDKHGKRLFGEARHSKSADMTCACSRRKAELLESGRDYVALHCNSLGNYEKLQCDSGLCWCAEEKTGDLVSTIVPEKAMNKLPCYEVATTGSQYLRQCDSIADAMAKTTHALKNHGVTYINLGVRVCDGDGAYGVYNVSDGIAYCTWRDGSKISAYQSNSEDDFASLNCRCARDYVLYKHGLRCLGSGNYRSYQSIIQDDTDYYYCVDDDGFQKSDLQDTVPENCTIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IC22</accession>
    <name>A0ABM5IC22_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129542.2">
        <property type="nucleotide sequence ID" value="XM_028273741.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273741.2">
        <property type="protein sequence ID" value="XP_028129542.2"/>
        <property type="gene ID" value="LOC114325631"/>
    </dbReference>
    <dbReference type="GeneID" id="114325631"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF450">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129542.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="338" mass="39674" checksum="3A54CDCDCA1D2AA8" modified="2025-10-08" version="1">MEIKQETTVKTCKIETYNEACDGSLDVFKIIEIKEEPKGECAYYDTFDYGDLKNEFPLKTEVEDEYKLTSFEEKQTKNEESSPQEDNKTEIMETSTAHPSHKGKCNRPYKCETCFKQFTRPRNLKIHLRVHNGEKPHKCEICFKQFSERGTLKRHLRVHTGEKPYKCEVCCKQFSQKANLETHLTVHIGEKHYKCEICLKQFFRGSALKRHMKVHTGEKPYKCEICFNQFSEASTLKGHLIIHTKEKQYKCEICFNTFFKASALKMHVRVHTGEKPYKCEICLKQFSKKSNLESHLTVHTGEKHYKCNICFKQFVKVSAFKKHMRVHTGEQPLGVKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IC77</accession>
    <name>A0ABM5IC77_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endocuticle structural glycoprotein ABD-4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129656.2">
        <property type="nucleotide sequence ID" value="XM_028273855.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273855.2">
        <property type="protein sequence ID" value="XP_028129656.2"/>
        <property type="gene ID" value="LOC114325725"/>
    </dbReference>
    <dbReference type="GeneID" id="114325725"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046765111" description="Endocuticle structural glycoprotein ABD-4-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129656.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="16439" checksum="E7C0C156C48FA5FE" modified="2025-10-08" version="1">MKLFIVCLAILSVCYGRPADAPAASAAPAASGPPANAQPPVALIKYENEGVNADGSYQWSFEAANGIKQEEKGSFKPGASEGESIAEVSGQVEYTADDGTPIHLSYIANENGFQPQGDHLPTPPPIPEAIQKSLDFNAAHPQAEDAGAGAGSPPGAAAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IG18</accession>
    <name>A0ABM5IG18_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131913.2">
        <property type="nucleotide sequence ID" value="XM_028276112.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276112.2">
        <property type="protein sequence ID" value="XP_028131913.2"/>
        <property type="gene ID" value="LOC114327476"/>
    </dbReference>
    <dbReference type="GeneID" id="114327476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="3">
        <location>
            <begin position="431"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131913.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="697" mass="81372" checksum="8E6AC7EF91CD916E" modified="2025-10-08" version="1">MATRDRRVLEEKQLFYKEKNSSSDSDFDSDDSVKDREYSPLTSSSESDESSPKRRSRQYHIATADNNQRQVEGNRGSIILTPEKLSPSRWRKVNIEERKKTKAKKRRNLGHVYISLRGAAKEAKKIGDPCKCKKKCRELLRGTELSIFNGFWDLETYEKQNTYLFSTIKVINKKRSYKQKTKRQESIRKFTNLYFVKVNGVDVQICKQEFLSVHGLQNSTKRIKLISKQISEGRATPKKDQRGKHHNRPNKVLPEMVQSVHDHIRNIPKYVSHYSRIDNPNRVYINHDLSVSSLYKDYYIAWCKERNIIPVKEDRYRRIFNLEYNIGFKMPKTDTCSTCDSLNIIISSNNANESEAEHLQVKLRLHQTRAQAMQQNLKDEIKKNEEIHNTDIISFDLQQTLPTPSLTVGVAFYLRKAWTYNLGIHDCVSGQGHMFMWTESVAKRGSSEIASVLLKYITSKPTRSENLVVFTDNCGGQNKNWLIMALWLQLVREKFYKTIEHRFLVSGHTHLPSDRDFALIEKHKKYVTQVFSPEEWFEIVRKSNRKNPFAVVEMSQDDFYSFDEIVITKKTCTTEKQPLNFTDVRCFRFDSEHPNSIFIKHTLNGAFDEVNVGKRGVKFGDNILTTKNLKKKYGGPIVLNIKKIQDIKKLLQYIPPINQQFYISIIENSTSNIEQDYNVDEAEELDRGDETDFFNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IH91</accession>
    <name>A0ABM5IH91_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132725.2">
        <property type="nucleotide sequence ID" value="XM_028276924.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276924.2">
        <property type="protein sequence ID" value="XP_028132725.2"/>
        <property type="gene ID" value="LOC114328146"/>
    </dbReference>
    <dbReference type="GeneID" id="114328146"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046257935" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132725.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="234" mass="27266" checksum="6A07F261845CFBF1" modified="2025-10-08" version="1">MELLQFFTVVFFVVFVKASDLDDARKILDCAQKALKVGVPDLDLPSYNPLDYDKDIPYFKDLAGELYFLYHNTQVYGIPDWQVKEINQINQDSDAFAVFNFSLTFQQLNASSNFDLNMTDFFFQTEYNGTQTLKLFNNEWTGSINVTKPNQDSVEQINDLQISWRAQRLLPVVHTNPSGYESLFASVYNYTIMTALSKPNTFVGDFLQEKLNTDWWLNGKIWKLVQWCEDNEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHT4</accession>
    <name>A0ABM5IHT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133129.2">
        <property type="nucleotide sequence ID" value="XM_028277328.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277328.2">
        <property type="protein sequence ID" value="XP_028133129.2"/>
        <property type="gene ID" value="LOC114328468"/>
    </dbReference>
    <dbReference type="GeneID" id="114328468"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF39">
        <property type="entry name" value="DUMPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046496410" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133129.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="608" mass="68497" checksum="733A60000DBCBC45" modified="2025-10-08" version="1">MRNIQNFFRVLLVLHCYLVILVEPSYNNELVPEGYQTNYGNPYTDYPYRYATNGNIYTTDVYGLTSVLRSGYARGYSYQTYKANPSAGQSHRSASTNDVYVTDQYGRTTLQSGRSAVQSGDSNRGYRYQSYYTNPSVGQSYRSASNNDVYVTDQYGRTTLSSGRPGYSYQSYYGNRYADHAYRSASNNDVYITDQYGRTTLQSGRTAVQSENSNRGYSEQSYYRNPYADHVYRSASNNGVYVTDQYGRTTLQSERTAVQSADSNRGYSKQSYYRNPYADHLYRSASNNGVYVTDQYGRTTLQPERTAVQSGDSNRVYSYQSDYRNPYADHAYRSASNNGVYVTDQYGRTTLQSGSTSVQSGDSNRVYSHQSDYRNPYADHAYRPASNNGVYVTDQYGRTIQSSGSTSVQTGDSNRGYSYQTYYRNPHADNSYRSASNNGVYVTDQYGRAIQSSGRNSVQSGDSNTGSWYQTDYRNPHAVHSYRSASNNGVYVTDQYGRATESSGRNSLQSADSYRGDWYQTYYGNSYADHPYSSATNAVTTLRSGDSYKGQCEDTQCPDSQACIENKCQNVCPNKCGVNADCYVRGHRPVCTCPTGYHGDPQIHCYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKK1</accession>
    <name>A0ABM5IKK1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pupal cuticle protein 36-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134956.2">
        <property type="nucleotide sequence ID" value="XM_028279155.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279155.2">
        <property type="protein sequence ID" value="XP_028134956.2"/>
        <property type="gene ID" value="LOC114329896"/>
    </dbReference>
    <dbReference type="GeneID" id="114329896"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045395547" description="Pupal cuticle protein 36-like" evidence="4">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134956.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="36630" checksum="973C1E7769E37B4C" modified="2025-10-08" version="1">MYCDMQQVRTAVLVLALIGISACARLDYLPPGRGNAGGGGPGGYPGAVAPGTGGGRGGGYQGGPGGGYQGGSGGGYQGGSGGGYQGGQGGAGGGYQGGSGGGGYQGGSGGGYQGGSGGGYQGGAGGYQGGGGGAGGQGGYQGAGGAYSGAGGAGGRPGAGSEIPIIRYENNNNGDGTYNYLYETGNGINADESGDARGDGTQAQGSFSYTSPDGQQIQVSYTADQNGFQPQGAHLPTPPPIPPEIQRAIDQNLADEARGIVDDGQYKPGADEGQGGYSGGQGGYSGGQGGYSGGQGGYSGGGQGGYSGGQGGQGGYSGGQGGQGGYSGGQGGQGGYSGGGGQGGRGGYSGGAGQGGRGGYSGGASGSKGGAGGAPSGLYGTPGTGSGQRGPDGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILM4</accession>
    <name>A0ABM5ILM4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell surface glycoprotein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135794.2">
        <property type="nucleotide sequence ID" value="XM_028279993.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279993.2">
        <property type="protein sequence ID" value="XP_028135794.2"/>
        <property type="gene ID" value="LOC114330596"/>
    </dbReference>
    <dbReference type="GeneID" id="114330596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047473028" description="Cell surface glycoprotein 1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="6">
        <location>
            <begin position="649"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="6">
        <location>
            <begin position="863"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135794.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1414" mass="158178" checksum="7E210245041E26B2" modified="2025-10-08" version="1">MGSMSRPVGVFCLVQVLCFWTVYVQGHVALTFPPARKYDLDFLDSSRTKPPCGMPKGNIKTSLLEGSKFNVTWHLGYPHRGGFKIQLLDFLERPVLDLTPTIQGSEFVSNDATAQSFHVQLPNQFNCENCTLRLIRQALEWGQSYKFWSCADVDILPRRKFRETCSGHGKNLVGRCKCDRLYYGEICQYRDECVENSDCGEHGKCIDVGGTVFPKQQCYCQLGWYGPGCIKRSAVRTTEIDLELYTEKQLSPTFRLYWRILKEHNELEAVLVVNGTSYAAIGWRPTSLTKSCKNFPIIGPVGTSGSDHSKAEPNPKSEPEPKSEPEPTSVPEPKSEPEPKSNGEPKTKPEPKTVPEPKSEPEPKSEPEPKSEPEPKSEPEPEPTTTQQPSKYRKSLYSRRSASQSPALRRALPVSDVVETSVSFQVSRKQGRRRRDVETVPEPTTEQETTQEATTLPSAEPDLTPVPEPEPKSEPAPSPEPTTGKPKSEPRARLDLKPKLRLQPKALKPIPTSTPEPKSEPEPKSQSEPNSVPEPKSEPEPKSEPEPTSVPEPKSEPEPKSEPEPNSKPEPSSVPEPKSEPEPSSIPEPKSEPEPTSVPEPKSEPEPKSEPEPKSEPEPKSEPEPKSEPEPKSEPEPKSEPEPKSEPEPKSVPEPSSNTEKLSKIQVSTVGSSAGPEKEEHLNPYTPRHDFNPMDCTDIIIGMARGNNSRIADYYTRDRSTPRMDSFWGGKNDLTTAMGFEKDGVTTILFRRKLDSKEPTDHAITNDLMHVIFAQGQEPGKYIHVPKSGVESAEAKIKDFYKPDELKYHGHKEQRGVVSLNFFDEKKMVEPAGVIATSDTAENRDCGGIWKIPRNCNPDNYTCEYSAKWELIPRKETIRFTITTKHIDTWTGIGFSHNEKMSQTDAILGWVDKAGRPFLMDTWINGYSLPLLDSTQNIFNTSGKIVNGVTTLSFARKRISDDSKDLSFADDTCLFMMFPTRGGAFNSVNKKIRKHEVIPTVSTEKICIRSCGNDNSLDEHLTTTEATTTTETSGLDSNTNVKLTEQGENLEIPQQRTSQHEDLSIAIPITKTKDDSFDEYLTTTEAPGLGYIMKVKLIELGENYKIPKPGTIQYEDLSNSIEESFKPVFNRLSGYRRLHIEQINSDQNNLVATINLQLANPSAETGRFLTEDTSEMDEKVHKLLQNSVGSGRVGNFKVDPQYQVFEPQSITTNLITDASSSSANNFFNLTEAKLYIVLGCIAALAIVAIIQASCTIYKARSRSSANHKDHLIPNSAWKDYSSNTNYAFDAFETPSTVTLEEKKHSNGNTNGTSTKPTKSRHIQRPQTRPPSVPPAAPQGDTRSLQRPRMGNYPPTNMDRNTFSLPRTVYDRNHYQDRGRQGPDMQPADFYFMPSQRKYSGEVVRVYVDYNNQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPX1</accession>
    <name>A0ABM5IPX1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138447.2">
        <property type="nucleotide sequence ID" value="XM_028282646.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282646.2">
        <property type="protein sequence ID" value="XP_028138447.2"/>
        <property type="gene ID" value="LOC114332856"/>
    </dbReference>
    <dbReference type="GeneID" id="114332856"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF186">
        <property type="entry name" value="FI22312P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045945242" description="Lipase domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="77"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="7">
        <location>
            <begin position="362"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="715"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="897"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138447.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118156" checksum="89B5FAA587D005D6" modified="2025-10-08" version="1">MVSYANFWVLCLWISALVAVVVTFPRANPALEILDELHDAEIYKAVLSSMNDWKRKQEQKKITNRLKREDIVSACYRDLGCFEASGPFGYLDTVPDKPEDIGTKFLMYPGRRRRKRGSPPAEVPFEKLDDAFEWAKDGFNGSLPTKVLVHGFGSDCNYIWVYEIRSALMAVEEVNIICVDWSNGAALPNYVKASANTRLVGKQLSLLLRGLVEKNGLSLKKTHIIGFSLGAHIAGFAGSDLGNLSRITGLDPAGPLFESQDPRARLDQSDAEFVDVIHSNGENLILGGLGSSQPMGHVDFYPNGGRMQKGCSHLFVGAVSDIIWSIEVPIAELAETIISELTQKPVNRNNFNQASAVEGRSLCNHRRAYHLFIDSVSPRCHFPAFPCESYEDFIDGKCFPCTEERQCGNMGYYADRSKGRGQLYLITREEEPFCAHQYHVKIETSPSPVPIKSYGKIQITLVGESALNETFMMTRKDDEEMRLGESISRMIVPHPILSQPVQIEILYTAYSGWLSSGLTQWRINKVILMDSFGKTSSVCKKSLVLESGKPVLLPLYPGECNIPTTDYEAEDRIHIPDDNTTSTTKMSSFIPTQVVREGIIDNNNKSSEKDGISFKNAMEFFNIPWTNDRENYVLDETESSRAFNTRPVKNGYHDGTTKEIVEPILKPHSSKNARSHDPNKEVEITEPLLGPTTDKNAALKSVSTTAKEHVDIKTTTIQPLEEEDSSIWTPKKPPNTKKEPKKRQDESRILSGFDQPEKPENPIEAIVNTVQFLPQRLARMFEQAEKYAKETILPLVSTYTPRFLSEIITPQESTSQKYVPLRYEEPTTRPIITSRLLSNAERYRNNKKFDPPPSSIQPEFKTTDFTTPVTNIQKIRRKGEAEENRNKDVQELVAAESQHRNAQQSVTHLKTTPMPKEARRAPRDDLNAERSAPKDPLNSLINTVQVIPENIGKMLHHAEQFARNNVLPFVANLTPKFISDIFTQKPNEYPRYIPFASDEAWKEQYYRSRRSRYHGMKYEGYVTEEAPDDSTVYSHIQRIPKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQK2</accession>
    <name>A0ABM5IQK2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferritin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138873.2">
        <property type="nucleotide sequence ID" value="XM_028283072.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513151.1">
        <property type="nucleotide sequence ID" value="XM_050657194.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283072.2">
        <property type="protein sequence ID" value="XP_028138873.2"/>
        <property type="gene ID" value="LOC114333216"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657194.1">
        <property type="protein sequence ID" value="XP_050513151.1"/>
        <property type="gene ID" value="LOC114333216"/>
    </dbReference>
    <dbReference type="GeneID" id="114333216"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF51">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028314" description="Ferritin" evidence="6">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138873.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="25913" checksum="28ECDFD0FAAAB8D7" modified="2025-10-08" version="1">MPGIMKAFIVLSIFCVAALASQDSCYNDAVTACDPAAARSVDKLNNCNAKFGGIDSAQSDLQKFVNHNFIRSFEYLLLATNFDNYQRNRKGFEKLFRGLSDKKWNDGIEFIKYLTARGGEVDFNEISDGVKKEEAQPVSFDLNELTAVSKALDLEKKYVHDAFSIHLGAARSNKQFYDPELTDYLEKEVVHEQREIIRKLAGYSTDLSGLLDGPDSSLALFMFDDYLQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISW7</accession>
    <name>A0ABM5ISW7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140947.2">
        <property type="nucleotide sequence ID" value="XM_028285146.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285146.2">
        <property type="protein sequence ID" value="XP_028140947.2"/>
        <property type="gene ID" value="LOC114335000"/>
    </dbReference>
    <dbReference type="GeneID" id="114335000"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045235431" evidence="1">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140947.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="118" mass="13590" checksum="6E4139FBFEA1E678" modified="2025-10-08" version="1">MNMLYCFFCIMLLPILTIYGDEISECKCKDGFSAVKDEHGNVYCQGVVLKSILPCNIVFKPDCVCSVEATSVVQDSSGTWCGRFIDGKEDRRWECENKAEWETFYQEHPEEKPKQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYM4</accession>
    <name>A0ABM5IYM4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149718.2">
        <property type="nucleotide sequence ID" value="XM_028293917.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293917.2">
        <property type="protein sequence ID" value="XP_028149718.2"/>
        <property type="gene ID" value="LOC114343101"/>
    </dbReference>
    <dbReference type="GeneID" id="114343101"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047001256" description="Peptidase metallopeptidase domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="12">
        <location>
            <begin position="85"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="485"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149718.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="553" mass="63327" checksum="001E728FCBAF4B9C" modified="2025-10-08" version="1">MLNGVDVLVFLLSLTYVLCADFSEKDAIVYLNRYEHNIDNKTDLSTSLITFQERYNLPVDGLLNNETIKFMRRPRCQHSDNDFIARTAWKKHHLQWYFPQRTVDAQKDAEMAFQMWQNVSNLTFTMVTTPGVDPPDITITMVSKTHYFRRNCMGGDECPTKVGGAVLGHSYFPNADGTCIEIHLDIDQSWHFGTDSIPEGRTSFLMVLVHEIGHALGIAHSATPNAIMYSVYADKIRVLHDDDINAVQYLYGAKSKYAPIPKFTNMHIPTNISTTTILPPSSRQSIHPHHTTPHLTSTTTTRPAPPRQSIHPHHTTLHTPSSTTTRPTTRKQLIFKNLCDIIPDFMFLATAPEFSNYRLYIAHNKFIWKLDLNGMIIPSQPELLIDYVPTELRQYTLQHIFQTTSGDLVTIVSPNKYFSASFPSIQYIDNFSINIPNKARINAIFQSNAGRSYTFYNNMSYIEFSNDFMTESGRGKIKDLFPGIPEDISLAFRWTDGHIYFFRQSNYYKFNEFTRKVVAGGQFSWNLFGVPCPNENILYQLKTLLSKLTSIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIS9</accession>
    <name>A0ABM5JIS9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497844.1">
        <property type="nucleotide sequence ID" value="XM_050641887.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641887.1">
        <property type="protein sequence ID" value="XP_050497844.1"/>
        <property type="gene ID" value="LOC126879010"/>
    </dbReference>
    <dbReference type="GeneID" id="126879010"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046371919" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="127" mass="13940" checksum="5B28E222146767D7" modified="2025-10-08" version="1">MKGTIFCVVLIACVLTTAADKYSHLGEAVKECGAEHGGPNEIKGPMDLQKHGATAFCILNKGEIITENGDIIENTVREIYRNIYATETEVDAVIHKCGTKNGKTREEVAFNLFACFEHLPPETKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKM8</accession>
    <name>A0ABM5JKM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Dynein heavy chain 2, axonemal</fullName>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498494.1">
        <property type="nucleotide sequence ID" value="XM_050642537.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642537.1">
        <property type="protein sequence ID" value="XP_050498494.1"/>
        <property type="gene ID" value="LOC114327420"/>
    </dbReference>
    <dbReference type="GeneID" id="114327420"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="222"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal heavy chain 2/5/8 coiled-coil" evidence="26">
        <location>
            <begin position="1092"/>
            <end position="1209"/>
        </location>
    </feature>
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        <location>
            <begin position="1278"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1825"/>
            <end position="2151"/>
        </location>
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        <location>
            <begin position="2317"/>
            <end position="2434"/>
        </location>
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        <location>
            <begin position="2655"/>
            <end position="2740"/>
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        <location>
            <begin position="2795"/>
            <end position="3073"/>
        </location>
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            <end position="3415"/>
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        <location>
            <begin position="3445"/>
            <end position="3666"/>
        </location>
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        <location>
            <begin position="3913"/>
            <end position="4026"/>
        </location>
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        <location>
            <begin position="4058"/>
            <end position="4197"/>
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        <location>
            <begin position="4204"/>
            <end position="4501"/>
        </location>
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        <location>
            <begin position="1208"/>
            <end position="1264"/>
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            <begin position="3614"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF17857"/>
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            <dbReference type="Pfam" id="PF25007"/>
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            <dbReference type="EnsemblMetazoa" id="XP_050498494.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="4505" mass="521240" checksum="F2CA994D38D9D430" modified="2025-10-08" version="1">[encoded data, 4505 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription rescue factor 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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            <taxon>Coleoptera</taxon>
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            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <dbReference type="EnsemblMetazoa" id="XP_050498720.1"/>
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        <source>
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    </evidence>
    <sequence length="197" mass="22403" checksum="D8ABD7A837639042" modified="2025-10-08" version="1">MSCLFNNLFKKAVVHSIVENSLKAYHFQRSVFLVPIAHPKFATNRYKSKSSRSKGKLINKVSESETESETKDDDIFDVNDKSAKTIEVRVSSLRADSILKVGLGISRNKLETIFYEGRIRVNGTKIPKKSVSVRENDELDVIKGKQTNSDFLTISRLLLLGIKAEEDIIKIKLRRHKSLTVENYEGRDAWTQSESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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    <name>A0ABM5JLV6_DIAVI</name>
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        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF47459">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20283" checksum="0D8FF7244AFB3AB9" modified="2025-10-08" version="1">MKTEIRKPPSESRKIRKPIMEKKRRARINDSLETLKQILLQSKTDLQEAKKGQRTAKLEKADILEMTVQYLQQLQEKDKENQSKPVSVKQNFPVSATLMKKVSNQQKPLRICSNSVNKEPVAIRPADSSSEKANFGVRLLPTQLISGQVVYLLPSNLNVNNINSNYADSKDKVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMY1</accession>
    <name>A0ABM5JMY1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499297.1">
        <property type="nucleotide sequence ID" value="XM_050643340.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643340.1">
        <property type="protein sequence ID" value="XP_050499297.1"/>
        <property type="gene ID" value="LOC126879949"/>
    </dbReference>
    <dbReference type="GeneID" id="126879949"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="165" mass="19495" checksum="EFBC7EB947243F1E" modified="2025-10-08" version="1">MPRRKKGGDLASSAAKRRKQKEHRRNETEEEREARLQNQRTRMRTLRSTKNEERKENESIEESRILKDNLTKEAFHYELTKKYYNHKHVVIGKMDNICQFCHAKKFSKETAGLCCMNGKIRLPPLEAPPQEFLHYMTGETQESKHFLQNIRLTSKNPASLTVSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNX6</accession>
    <name>A0ABM5JNX6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499641.1">
        <property type="nucleotide sequence ID" value="XM_050643684.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643684.1">
        <property type="protein sequence ID" value="XP_050499641.1"/>
        <property type="gene ID" value="LOC126880048"/>
    </dbReference>
    <dbReference type="GeneID" id="126880048"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13577" checksum="AE169592F5D9FAC1" modified="2025-10-08" version="1">MSRNRPLTEAELQYIGDHLSDEEYCLSEFDGDEDADDNFPGTSSIFRTPSQSSTTSIDSQPKCSSTSVQHLKRVRQCTLTRNTNNSSGNEDFDDSDQDPDFDPDDGFGFKHNKLVFLINDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPC8</accession>
    <name>A0ABM5JPC8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499786.1">
        <property type="nucleotide sequence ID" value="XM_050643829.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643829.1">
        <property type="protein sequence ID" value="XP_050499786.1"/>
        <property type="gene ID" value="LOC126880124"/>
    </dbReference>
    <dbReference type="GeneID" id="126880124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="130" mass="15434" checksum="5CF904A9DE098E13" modified="2025-10-08" version="1">MILSCVDAERSDDTIFFIWISAVSLFRIVNLLQLSSCHHRYVLQRDAANQSMRSCPHPLFYDLVVRKRGRLLLFGVGNRLGKESFETYSSRQRRFIIRLSEIDQQHHNSPMISRKMLTKLWKLWKLLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ85</accession>
    <name>A0ABM5JQ85_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500102.1">
        <property type="nucleotide sequence ID" value="XM_050644145.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644145.1">
        <property type="protein sequence ID" value="XP_050500102.1"/>
        <property type="gene ID" value="LOC126880342"/>
    </dbReference>
    <dbReference type="GeneID" id="126880342"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="533" mass="64880" checksum="B0E9258A6028D8D6" modified="2025-10-08" version="1">MSVTRSQSKDNKKQKEHSNQENNSDQEDILDKTIMASEQQELSGIDKLLQMMQLQSQRMEQKMDETQQKLDDNQRETKQTMDKNQEETKQAMEKNQEETSKKMDKVDQKMDETQQKMDETQQKMDETQQKMDKTQQKLDQKMDETKRIMQENQKETKQAIEENNKKMEERIEKYEMKIQDKIKELTNGQKKELENLENKLQNAIQADIEEVERKIAEINTQQNVGERREMVIHSTDDVKIRFGGDVRRLHPVPFINSLKKKIQHIGNFETAKETIRNHLKYEASLWFDSKEEEFGNWQQFEQKFLNYLWGKVQQLEINKELQNGKYNDRMGVSERTYALQIYNNAKHLQYNYSSEQLVELIARHFEETLEDHITLQNYKDIDSLCQFLQIRESRLRERKSRRSREDYRPRETQDYRDRNQDRRDYTRRDFNPRRENENRDNGRGNYEQRNRQWYEDRNREYQNRNTTRSNQENRNNGRQNEQGYRENRNRSDRPRENRREVNNTQTHEYDGERHYDENINNDEQPASFHDGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQL1</accession>
    <name>A0ABM5JQL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050500226.1">
        <property type="nucleotide sequence ID" value="XM_050644269.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644269.1">
        <property type="protein sequence ID" value="XP_050500226.1"/>
        <property type="gene ID" value="LOC126880425"/>
    </dbReference>
    <dbReference type="GeneID" id="126880425"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="313" mass="35384" checksum="907F13B30B4581E0" modified="2025-10-08" version="1">MESKKITSLETLKTFISEKDNSQNTVYISDIPDVCKEFPCILGIDEAGRGPVLGPMVYGICFCPINEQMILEKLECADSKALNEEKRDTIFSNICKESKVVGWAVEIISPNSICNSMLSRTKYSLNQVSMDSAVGLVRTAEKAGVKIEHIFVDTVGPPEKYEEYLKNLFPKYKVKVSKKADSLYPIVSAASICAKVTRDHALKVWTFQEGLDLTHEQFGSGYPGDPVTKKFLVDHCDPVFGFPQLVRFSWSTSQNALKETAYHVEWEEVDDTKSPPVNNTSITSFFKMTKEKPTVKTRHEFFTQRCLDRKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR75</accession>
    <name>A0ABM5JR75_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500435.1">
        <property type="nucleotide sequence ID" value="XM_050644478.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644478.1">
        <property type="protein sequence ID" value="XP_050500435.1"/>
        <property type="gene ID" value="LOC126880547"/>
    </dbReference>
    <dbReference type="GeneID" id="126880547"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="190" mass="21841" checksum="747B57BB97F78866" modified="2025-10-08" version="1">MGKQNSKLKPEVLEDLKQNTEFSDAEIQEWYKGFLKDCPSGHLSVDEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTAIYKMVGSVMKMPEDESTPEKRTDKIFRQMDRNKDGKLSLEEFIEGAKSDPSIVRLLQCDPQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUS7</accession>
    <name>A0ABM5JUS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501696.1">
        <property type="nucleotide sequence ID" value="XM_050645739.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645739.1">
        <property type="protein sequence ID" value="XP_050501696.1"/>
        <property type="gene ID" value="LOC114338398"/>
    </dbReference>
    <dbReference type="GeneID" id="114338398"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="8">
        <location>
            <begin position="155"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="402" mass="45423" checksum="6CA76AD87CC4A3ED" modified="2025-10-08" version="1">MLEMDVRNQKLEQQRQLMEQKMKQKRLTSGMIQVSDIRNNSANSRNSVNSNRRDLHGYDGPLQFAMSNDNNPDQVISILPSVDSMDGTLVEDLTNASSDLMDVEDEESSPVASTPNDNGNMPINPIPDKPNFIHHTNGASEVEGDIEGNVEKFILQPAQLKVLYKCRITRDRKGMDRGLYPTYYLHLEKDYGKKVFLLAARKRKKSTTSNYLISTDPTDLSRSADSFVGKLRSNLIGTQFTVYDNGISPRKANLKDGVIPRQELASVIYDTNVLGFKGPRKMTVIIPGMVDEQRVTIYPQDESEGLIESWKAKNMDNITELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQIVHDSDTDYVVMQFGRVAEDVFTMDFRYPLCALQAFAIALSSFDSKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVI9</accession>
    <name>A0ABM5JVI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501955.1">
        <property type="nucleotide sequence ID" value="XM_050645998.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645998.1">
        <property type="protein sequence ID" value="XP_050501955.1"/>
        <property type="gene ID" value="LOC126881625"/>
    </dbReference>
    <dbReference type="GeneID" id="126881625"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="158"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="611" mass="69697" checksum="46EEB22DD1192540" modified="2025-10-08" version="1">MAADSSMYVRGRDGKGLLFHELLEALEEENEMPEYISIFPPEEPPDADTDKDSDFSDEEVAGDTNHLPARILRSQVSVKYSHEIKAADDTNNVSQPSTSRQNNISQPCTSKCPKSAKRPRLNPTTWKSNIFEFSSKVPEPDNEYRPNVEDLLKETVKSPIDAFRCYFTQDIIEHIVRETNSYAGQKLVHNLNATSAEILTFVGVMLLSGYHPLPCRRLYWTVDEDVHTPIVSNAMRRNRFDELMSFIHLADNQCNDGTDRMYKIRPLLDMLNSAFKQITPGPTVSVDESMIPYYGRHGSKQFIRGKPIRFGYKLWVAADPSGYIHHVEPYCGSSTRLPQTGLGQGGDVVIGLIDHMQLKKGHRLYFDNLFTSVALLQELSSREIGGTGTLRENRCNASMKLPEKSVWKKKERGDVATSSSGDLLLVRWNDNNVVTMLTNCDKVYPMKKASRYSRAEKKKITIDIPGPVEQYNSNMGGVDIMDQFVASYRCRIRSKKWWWPFFSWAVDAACVQGWLLYRRLGYDIPLLNFRRQCTVYLLKSFGTLPKIPGVRTSLNFSPVLQELRKDHTDHIIQKGASKYRRCKVCGNRTSYLCIKCDIALHPDNCFKVFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWH2</accession>
    <name>A0ABM5JWH2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502291.1">
        <property type="nucleotide sequence ID" value="XM_050646334.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646334.1">
        <property type="protein sequence ID" value="XP_050502291.1"/>
        <property type="gene ID" value="LOC114327133"/>
    </dbReference>
    <dbReference type="GeneID" id="114327133"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046966094" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="354" mass="39167" checksum="07804B1938F6C4E4" modified="2025-10-08" version="1">MGNLVFIVLCAISVICGFSNSYASEDYKIGSKCYNSGAPGICKSVTDCPQAIGLLRKGHQHNFKRCLFANMIEIVCCPDSIEKGSTEVDQQRKYQQACDKIKAEAGVDIKYITLGEDALDKEFPHMVALGYVDSNLPQGELSWRCGASLISPNFLLTAAHCVFKEKPLRARLGVTRINDTHHQEIDVKRIRIHESYDPLGKHGDLAIIELKRNATFSESVRPACLYWKHDDPLELLVTGWGKTTSVFYEDDRSIILQKARLVPVSVASCNNTYSTRYLGTRTIENTQICAFGNLSDACWGDSGGPLQIREGKGAFSIFSIVGIVSYGAGCGGKIPGVYTRVSQFVDWIENYVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K066</accession>
    <name>A0ABM5K066_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503583.1">
        <property type="nucleotide sequence ID" value="XM_050647626.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647626.1">
        <property type="protein sequence ID" value="XP_050503583.1"/>
        <property type="gene ID" value="LOC126882652"/>
    </dbReference>
    <dbReference type="GeneID" id="126882652"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34232" checksum="5DB9AE10E8923A8F" modified="2025-10-08" version="1">MHLRSLKSLGQPTESWDTLIIYLVFTKLDPVTIREWESKDFMNDTPKLEAFLTFLKQKSKMLKRMEEKPTEANSSQNVKGQTSKPPAESSNRSNSHVQRSYQISNRTCASCDAPNHKIYTCTKFLRLSVPERTDLVKKSNLCINCLNRGHQVNNCNFGHCKNCTVKHHSLLHVSEPSTSNTNTQQSLFTFNLSSKQVLLSTVLLEVVDSKGNRHDCRALLDPGSQSNFISSHLCHKLALPRKPTNITISGAFKVESKIQAVCQIQIVSKNTPFTAPLVCLVAPEICDVVPEAPIVPVSLSIPTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0D6</accession>
    <name>A0ABM5K0D6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503653.1">
        <property type="nucleotide sequence ID" value="XM_050647696.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647696.1">
        <property type="protein sequence ID" value="XP_050503653.1"/>
        <property type="gene ID" value="LOC126882714"/>
    </dbReference>
    <dbReference type="GeneID" id="126882714"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="70151" checksum="287A5B49A632782D" modified="2025-10-08" version="1">MSDQNKTKRMATKGALTRLTTYFRSVENNEVIDLVDFEMRLSKAEELLDVFNEVQLLIETDDPDCEENYDTIHAIERQTFEDRYFKIISDIKKLILSRRPTDTSDSRSVNGSIAAGPTNTSNIKLPPLNLATFDGSFDQFLFFRDSFNSIINDDTSLSNVQKFHYLRLSLRGIAADTIKSLQVCDANYDIAWSLLIERFENKQLLVNNHIKALFNLPLVTKESNEGLRQLLDNTQKHLRALEVLKRPTKHWDDLIIYLLTTKFDNSRRRSWESQNCKDNLPVLDDLLKFLKERCRILESLDNYNDNRQDQNSPRYKGNKSETRAFVSNTENRFKCNFCNKEHKIYYCPDFLKLNPTNRLNNAKRLRLCLNCLGTCHRTKDCRSTGCRKCGKIHHTLLHFENSQSSNSVSTENNSSQSSLPSNVPNTGLQSNESTSTSNFSSTHHISSSVHTAIKPYILLSTAVVNAFDKFGNSHKCRVLLDNGSQSNFISEKFCDILQLSKEKINTSISGINQLTHNINFRTSLTFKSDINNFSKKISCLILLNITSNLPYIQINRSQLNIPTKLLLADQNFEKPGPVDLLIGADTFWDILSVGQIKLGPGLPIIQKTTLDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3X8</accession>
    <name>A0ABM5K3X8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050504892.1">
        <property type="nucleotide sequence ID" value="XM_050648935.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648935.1">
        <property type="protein sequence ID" value="XP_050504892.1"/>
        <property type="gene ID" value="LOC114325331"/>
    </dbReference>
    <dbReference type="GeneID" id="114325331"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17098">
        <property type="entry name" value="FERM_F1_FARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01220">
        <property type="entry name" value="PH1_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13235">
        <property type="entry name" value="PH2_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="54"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="621"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="839"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1119" mass="126691" checksum="B7F9871339D2FEF7" modified="2025-10-08" version="1">METNSSNRGSTGALSSTGGSASVGMHHSLSTPAGVDCGGSRTPPATPKKGGKMLAIRVQMLDDTVTIFQVQAKAVGRVLFEQVCKQLHLLEADYFGLEYSDDHGTKYWLDLQKPISRQLGLSLVDPLLYFCVKFYTPDPAQLEEEYTRYLFCLQVKRDLSQGSMQCNENTAALMASYIVQAECGDYVAEDYPDHTYLSSYKFVPQQDHEMERKIMENHKKHAGQSPAEADLNLLETARRCELYGVKMHPAKDHENVPLNLAVAHMGIIVFQNYTKINTFSWAKIRKISFKRKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCSSVKHVSRHKTRVLSRGSSFRYSGKTQKQIIEFVRDNYVKRQTFQRSQSFRHSSAHSSASNMHSHSTTVGNSISAHPLLPLADTNLSVEVSKLSASLGSMGAHVGPRPGSPTTKSASRHLGTATSWSSVPDTRPSTLPPNQTMSSPEESAIMSPIHTKATITSSPLAVRAAVHRADTDDSKKELLERTKVEDAKIRDNNNFYTSTPLRSANGNVSELSLAASNGNYSTTNTLNSDDSPSKVLAKEQLMNSINANTMVNGNSTNTTTIIAEIEGETKKKSKHVVDKTYYIAKEILMTELTYKKDLDVINVWFRDEVGKEEPEECQILLSLIAPLAQAHGLLVKDLEKRLKSWDIKGGPRAVPMAEKIADVLLAHLPPLLPIYEEYLDGHMLVLERLDAAFKQNNRFEQLYRDFETQKVCYLPLTTFVLKPLHRLLQYQSLLKRLLNYYDENHPDRTDCRTAIDTLKDLMLPVSETLEQSKNLATLCELQRDIVGFDNLVQPGRTFIRHGCLLKHSRKGYQQRMFFLFSDILLYTSRSQATLQFKVHGHMPLRGVLIEEPDGDLMFNGLIIYGGNRALTVAANSLEEKEKWKTDLQRAIQMARDKSDTKITYLSLKSCSSSDEHIDQVGNNDVGTQTKPQAQRSNTTVHVCWHRSTSISMKDELLAVENQLSGYLLRKFKSSNGWQKLWVVFTSFCLFFYKGCIDDFPLASLPLLGYTISPPLREDMISKDYVFKLQYKNHVYFFRAESEYTYNRWMEVIGSATQIRKRKAAVVNENQIETSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K454</accession>
    <name>A0ABM5K454_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC14-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504966.1">
        <property type="nucleotide sequence ID" value="XM_050649009.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649009.1">
        <property type="protein sequence ID" value="XP_050504966.1"/>
        <property type="gene ID" value="LOC114324385"/>
    </dbReference>
    <dbReference type="GeneID" id="114324385"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="2">
        <location>
            <begin position="276"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48718" checksum="5CE59D87070FBE44" modified="2025-10-08" version="1">MPRAKIELDDDKKFALMKFRRSLHDILQPQHDDHYLLRWLRARNWNPAAAEKMFRESVMFKKQWEMDSNLIAWDPPEPIKLFHPSGTCGLDKDGAPVIIVPFKGFDPIGMLSSVSKLELIKNEAKILETNLKMAAETGEHQLVVIFDMEDFDIKQYASRPAAELAISLIQLYEANYPEILKQCYIINAPRVFSVAFNVVKRFMNGYTLSKIKIFKNDPRKWQPVLLEAIDPDNLPAHFGGNLKDPDGNPRYTTVIKQGGKVPQSYYKKNIEVKNYEQEFTKAVIKKGHKCILDFIVVEEGCHLKWDFKTDEHDIKFGITLKDENGVESPVVRHRRVASHQIDESGVIACQAPATYIVTFDNKYSMFRSKTIYYRIYVTPPLEKLNIVPHDNDLNILQLNLDENLESPKKEQLNNNAVVEPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K462</accession>
    <name>A0ABM5K462_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504983.1">
        <property type="nucleotide sequence ID" value="XM_050649026.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649026.1">
        <property type="protein sequence ID" value="XP_050504983.1"/>
        <property type="gene ID" value="LOC114330901"/>
    </dbReference>
    <dbReference type="GeneID" id="114330901"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="14"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="538" mass="60368" checksum="ECD719961C523FF7" modified="2025-10-08" version="1">MKALNDPLRRTMAHVVQLAEGKISGGTRTDLNGDKFHSFLCIPYGKAPVGDLRFKAPLPVDPWEGVKQVITEDKTPFQKNIVLKEYTGEEDCLSLHVFTKKLPHEESKLKPVMVYIHGGGFIMGSHETTMYGPEYLMTEDIVLVSITYRVGLLGFLSIEDESLDVPGNAGLKDQVLALKWVQRNIRNFNGDPNNITIFGESAGGASVEFLLLSPSAKGLFHKAILQSGSTLNPWTLKNSPATEFAEFTKLHNLPDIDILKSLRRMTVRELYDQQNQYIKSKKLFVDFGLITPVIEKPNPTAFLTEKPIDIIQSGKYNNVPVIMGYTDSEGLLLDFLSALGMNGAKEGEDIPIEQILPYETNLTDAQQVKRLVEKLRNFYRPEADPVGRINLSTDALFAAGIITSAKNQAKVSKNPVYFYRFSLDAGLNMLKKMVNDTRPGACHGDELGYLFKNLLTTDIGDEDKTYIHRMVTLWTNFAKYGNPTPPGNNLNIEWKPIQNGQLNFLDIGKQLKMDVNPDADRMKIWNELYQCNPLTAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBZ9</accession>
    <name>A0ABM5KBZ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BLOC-1-related complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507711.1">
        <property type="nucleotide sequence ID" value="XM_050651754.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651754.1">
        <property type="protein sequence ID" value="XP_050507711.1"/>
        <property type="gene ID" value="LOC126885266"/>
    </dbReference>
    <dbReference type="GeneID" id="126885266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36712" checksum="7B6477F25BF62A5E" modified="2025-10-08" version="1">MDLDNILNFETLKCHTQCVSVGKRVLCEESEVPPSKKRRDVFSVDSSFVPPSVSGVRDSRKRAPSEESVIYVGSETLPLNQPRSEMGRLILKIKKNTAVAAQTFKVAAEVHASPSVQTSKHHSTSFEDISDSEDGTSDHPSLQTCNKPSIEGYPSIGDILNISELGSSPEEGLTQTHITQPQAEEEIPMKPMTETQVWEKELISRTEPSLTNVVTRVLQIPNRAEAYHQALCEDFKGGLVSALERHQDRIQERLNENLKESELLKKAIQNIFSYGEKISEAFHEENIRLSQDLINIKASLANAVRSDSRDLFNKNVAGDVLRCGMRDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD98</accession>
    <name>A0ABM5KD98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508171.1">
        <property type="nucleotide sequence ID" value="XM_050652214.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652214.1">
        <property type="protein sequence ID" value="XP_050508171.1"/>
        <property type="gene ID" value="LOC114329769"/>
    </dbReference>
    <dbReference type="GeneID" id="114329769"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="39046" checksum="2F492E596C5B8FDE" modified="2025-10-08" version="1">MQKKRRTKELCKVRSTLRNYLTVHTKLFNIIGLWTNEKLIAGSLIFTVLYSILALSFFIIAPQFCHVIYMYKARNNVMDFADEFYVSMSSLMVIFKDYTMIVYRKKVRQLIDSMDYDIFQPLNSKQQKSSSAVMNMWQKMFWIISVMQISFGLCVLITPALDRLRTGAKYLPLVDCYPFYIYASPVYEMMYIYQSCLLFYLIFHSFLFDTFIAGLLAFCVAECDLLHDNLQNLKQQMTHVEYGKRLIKCIKHHEELRKYSNAKSELLPVAAYDSYRLDALKSTQTNLKLFIGKTQNSLKIRTALFALSMEQYLQLLRNSFSYYAVLTTLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDA3</accession>
    <name>A0ABM5KDA3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050508176.1">
        <property type="nucleotide sequence ID" value="XM_050652219.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652219.1">
        <property type="protein sequence ID" value="XP_050508176.1"/>
        <property type="gene ID" value="LOC114333943"/>
    </dbReference>
    <dbReference type="GeneID" id="114333943"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14402">
        <property type="entry name" value="UBA_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021097">
        <property type="entry name" value="CPH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11515">
        <property type="entry name" value="Cul7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="535"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="587"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
        <location>
            <begin position="641"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="14">
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    <sequence length="4789" mass="530131" checksum="98EA12863203A97F" modified="2025-10-08" version="1">[encoded data, 4789 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF88</accession>
    <name>A0ABM5KF88_DIAVI</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    <sequence length="2220" mass="251637" checksum="4CAD1011A35013F1" modified="2025-10-08" version="1">MDSGKAQNLSDGERYVIALHTLFSLSAIKSYTNWEILNEVKSAGKFDDLVLKSHEKCILLQAKVHSGTTCTKHFTAIKGDFSIAKYFLSYLTAKKYFEITSNSLILCTAAKLNVADIMDEFGPETKNYADENLQKIFGTETKKYKIKNEEKIVDKLLSTIKQFQDSISNKETDKEKKVWKNLDINREDIKSFICFFVVVKENLANIESLITRKLRELNNDLKFKPSDYEYVKYHVEKWSHLPIKKSVPMTKDYLLFIINGENNRLFLHKFVNSKLKFKEENLYEFDSNIICVQPHDNIAMHLLKIFRSIENANGSYLPIEENTLCLMQKIENKFHKMKYTMEYKVICDMIDTFRCDKIKYLVVSFLSLDEDKSLELYEKICTITKEDPTKKVFIIIKEHQLQNSEISVKVINNKIYFNSLENETKEHIFDKEILFQEEIVTLRKLITKKKSVDSEPEFRVQINEIEIDEGLKEIIFSEDNYSIGSNIQAQSKPDEFYITRKLMLNANSENLQKSINNVERTIPILTDSDSESDSDSDSESDFDSDSDSDSYEHIRRDVFREKKFFEKIHKKIVVVIGPPGAGKTTALKQIVSFKKAKDKEDSKLTWVINVDLKKYKQCFQKDSEKTLCNLLYHNENITHYFEEKLMESMDKMLIIDGLDENCPEDIKEIQNILADHNAFQALNISMVIMGAREYDFILKEIRDLHSCEIVRLLPFSRRDGASFLKEYLKPAVNIENDLFKKVKNFAIKFSQSISSTPLSLKMISKIIKNSIRKNDCMESLSKVFNNFSNRYYFYNCYIEAIRDEFAQGDNIYRQAFDRYIDSLRILAANRTFYSRWIVLSFVNVDASLEISKDVLNVGLLKESYGYKMYQFVHKTFEEYFAAEFVWDYLYKNRHSHDLLLEVLDKVFIPAYYKGVLDFFEQILKVNQNEKISEISMEYNLALTKVHWKEDIVRVDNWNYFFIVKLVFDKYTHFYDILKSYDWLVLTKSLYNDRYRQSYAKFFVETGAKVNKVSEIGFIILKMLLLQDRLSVVTYVHRTEWSTFECDNIPEDEYSVDFLKFLTREYNIDLNFCNENGNTIGHYAARYNSLNAIKYLKEQGANLNISNNKKQTLVHVAAQVCAFNVLRYLVEDCKMDVNVSDVDGNLPVHRVVEFGRVDILMYLKEKGANLSISNNKKQTLVHKAAQSGNLEVLQYLVEDCKMDVNVSDDDGNLPAHLAASNNKVWILRYLKSIGSDLNPRNCKGKTSVHFAAAGDAVDVLNFLKDEGNISLNLDLRDKDGDSPSHCAAAKNSLTALKYLKKQGANLSISNKNKYTPVHIAAQYGALDVLRYLVENCKMDINVSTDIGEIPAHLAALSNKVEILRYLKSVGGDLNQCNNQGQTLVHLAAEGDAVNVLNFLKNECNFSLNLDLRDNDGFTPSHCAASNNALKAIRYLKEQGANLSISNKNKRTPVHEAAQRGALEVLQYIVEDCKMDINVSTYLGNLPAHLAALCNKVEILRYLKSVGSDLNQCNNQGRSLVHLAAAGDAVDVLDFLKNECNFSLNLDLRDNDGYSPSHYAAANNSLTALKYLKEQGANLSISNKNKYTPVHIAAQYGALDVLRYLVENCKMDINVSTGNGEIPAHLAALYNKVEILRYLISVGSNLNQCNNKRQTLVHLAAAGDAINVLNFLKNECNFSLNLDLRDNDGFTPSHCAASNNALKAIRFLKEQGANLSISNKNKRTPVHEAAQGGALEVLQYLVEDCKMDINVSTYLGDLPAHLAALCNKVEILRYLKSVGSDLNQCNNQGRSLVHMAAAGDAVDVLDFLKNESNFSLNLDLRDKDGDSPSHCAAAKNSLTALKYLKKQGANLSISNKNKYTPVHIAAQYGALDVLRYLVENCKMDINVSTGNGEIPAHLAALYNKVEILRYLISVGSNLNQCNNKRQTLVHLAAAGDAINVLNFLKNECNFSLNLDLRDNDGFTPSHCAASNNALKAIRFLKEHGANLSISNKNKRTPVHEAAQRGALEVLQYLVEDCKMDINVSTYLGDLPAHLAARCNKVETLRYLKSVGSDLNQCNNQGRSLVHMAAAGDAVDVLDFLKNESNFSLNLDLSDNDGFTPSHMAAANNSLKAIKYLKKQGANLSISNKDKYTLVHAAAEYGALDVLVYLVEECKMDVKVSDNNGNLPAHLAALSNKVEILRYLKSVGSDLNQRNHQGATLVDMAAEAGAVNVLNFLKNECNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFS7</accession>
    <name>A0ABM5KFS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509049.1">
        <property type="nucleotide sequence ID" value="XM_050653092.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653092.1">
        <property type="protein sequence ID" value="XP_050509049.1"/>
        <property type="gene ID" value="LOC126886228"/>
    </dbReference>
    <dbReference type="GeneID" id="126886228"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54139" checksum="3B08BE0ECD941201" modified="2025-10-08" version="1">MSSFISRKAANRLGWPKTPCSFEVNGLNSMQTKLNQGQISFSKQPRHLESPVFHLEAIITDRVCSDLPSTQIDISAWNYIKNLKLADPKFNCSQSVDLLIGCSIFSKVLLEGKIEGKPGQPDALNTVFGYILLGPTSTPNLSSTSLVCLSNVEDSLDSSLRKFWELENISEEPVSEPEDVLCETMYRETHSRDVSGKYVVSLPFRESPPCLKDSYDVALNRFISLERRLFRQPGLQKEYSSHMQEYIDLGHMQLVPEGEKTKGKYYIPHHCVVKSESVSTKIRVVYNASQKSPRLGKSLNDYLLVGPKLQQDIVSLLLNFRLNRFALCADIRQMYRNILVVPEHTDYQRVLWRFSSFEEIQEYRLLTVTFGVVSSPYLALRTLQQLVLDEGSRFPKAASLVCNASYIDDFVFGASTLEEAQSLVEELVALLKLGGFELRKWCSNEPNLLSQFPESHINPHSINLDPESNGPSLKILGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG70</accession>
    <name>A0ABM5KG70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509201.1">
        <property type="nucleotide sequence ID" value="XM_050653244.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653244.1">
        <property type="protein sequence ID" value="XP_050509201.1"/>
        <property type="gene ID" value="LOC114334637"/>
    </dbReference>
    <dbReference type="GeneID" id="114334637"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="114" mass="12415" checksum="D7E0C68C882006DC" modified="2025-10-08" version="1">MELASLQTKEESDAVNTILRNAPLITECWISGSKFDDNKWYWLKGEAMVFTNWKAGEPNNANGNEDCLAISNGGTSTGWDDEVCSVQLYPVCEKVVASQNGGSGCKAEVVNIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KID9</accession>
    <name>A0ABM5KID9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050509965.1">
        <property type="nucleotide sequence ID" value="XM_050654008.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654008.1">
        <property type="protein sequence ID" value="XP_050509965.1"/>
        <property type="gene ID" value="LOC114331660"/>
    </dbReference>
    <dbReference type="GeneID" id="114331660"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24660" checksum="1A249EB568B6BF46" modified="2025-10-08" version="1">MAKCQCKSTVKMEANGCQFQMITKAFVSKPAPYWEGTAAKGDEFVTLKLTDYLGKYLVFFFYPLDFTFVCPTEILAFNSKLEDFRGIDTEIVACSVDSHFSHLAWMNTPRIDGGLGKVNFPLLSDMMHTISKDYGVYLPNVGHALRGLFIIDRKGIIRQITINDLAVGRNIDEVYRLVQAFQYTDDNENVCPANWKPNGKTKKEKKGFFEKIEHGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KK21</accession>
    <name>A0ABM5KK21_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510557.1">
        <property type="nucleotide sequence ID" value="XM_050654600.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654600.1">
        <property type="protein sequence ID" value="XP_050510557.1"/>
        <property type="gene ID" value="LOC126887202"/>
    </dbReference>
    <dbReference type="GeneID" id="126887202"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="126" mass="14139" checksum="A38BF77ED0DFCFD3" modified="2025-10-08" version="1">MPHKKIGIKGLGLNSQAKAIIYNVTTCMEQEAAHFKTTENLLIPLSKLTNRILAATGISKNTLTKIRKDGRDVNKNGATYLSFKSPKRKRCRSKKIELSSGQVKTIKNIIYDFYTIEKRSPTINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKP6</accession>
    <name>A0ABM5KKP6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050510771.1">
        <property type="nucleotide sequence ID" value="XM_050654814.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654814.1">
        <property type="protein sequence ID" value="XP_050510771.1"/>
        <property type="gene ID" value="LOC126887357"/>
    </dbReference>
    <dbReference type="GeneID" id="126887357"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="390"/>
            <end position="417"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="474"/>
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        </location>
    </feature>
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        <location>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="561" mass="66093" checksum="53A67E1ADA609FC1" modified="2025-10-08" version="1">MEVATTKPFNSHKVDLKTCTGDRPYECEICSKQFTNRSYLKYHNLRIHTGEKPYKCEICIKKFTTTQVLTVHMRIHTGEKPYNCEICSKQFTQKSGLRYHMKAHTGERPYECEICTKEFTQLGNLKDHMRIHTGEKPYKCEICSKLFTHISNLNTHKRVHTGEKLYKCEICSKQFTKRSHLKDHMRIHTGEKPYKCEICSKQFTELVNLKRHMKVHTGEKPYKCEICNKKFTTTQYLTVHMRIHTGEKPYKCEICSKLFTALVNLKRHMKVHTGEKPYKCEICNRKFTTTQYLTVHMRIHTGEKPYKCEICSKLFTTKGSLKIHMGIHTGETPYKCEICSKQFTALVNLKRHMKVHTGEKPYKCEICSKRFIKLSNLKLHMRIHTGEKPYKCEICNKKFTTTQDLTVHMRIHTGEKPYKCEICSKLFTTEGNLKVHMRIHTGETPYKCEICSKQFTEVGHLKRHMKVHTGEKLYKCEICSKHFTRKYRLNDHMRVHTGESPNKCEICSQRFTTKPSLNYHMRIIHTGESPYKCEICNKKFTTTQNLTVHMRIHTGEKPCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKQ5</accession>
    <name>A0ABM5KKQ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510781.1">
        <property type="nucleotide sequence ID" value="XM_050654824.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654824.1">
        <property type="protein sequence ID" value="XP_050510781.1"/>
        <property type="gene ID" value="LOC126887365"/>
    </dbReference>
    <dbReference type="GeneID" id="126887365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25901" checksum="92D1E766BF62CE1D" modified="2025-10-08" version="1">MDKKAKRINYTPDEKNLLTQLVHANKDAVENKTTNAVSNTEKDEAWNRIAIQFNEMNHVHRDESSLRKQWSNIKQDLRKKAAESRRQLYKTGGGPPETKFKDEAMILEVVNTKTISGLDNMNDCDALSQPSTNTYEDVADNNAEDRNIQDRLAKRQWAQKRRPVKRNSAVEDAKLEVLQIQAEMLSQEMSNKNKLFQLEYEHKEKMFRLERQLIKKELGLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKQ7</accession>
    <name>A0ABM5KKQ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510728.1">
        <property type="nucleotide sequence ID" value="XM_050654771.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654771.1">
        <property type="protein sequence ID" value="XP_050510728.1"/>
        <property type="gene ID" value="LOC126887324"/>
    </dbReference>
    <dbReference type="GeneID" id="126887324"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="579" mass="67064" checksum="3A4DB223789CDE0A" modified="2025-10-08" version="1">MECNENKDSTNQEILTHIKGEGDSLQKYNSKEVKSEPDNSSYGQESVLDEYCSNSEDVKIENHVLEDVSNEIKVKIKNEPEECSNGGLQDITVKVTKPSSAPKVHLKTGTGETSHKCEIYSKLFTTKGGPRDITVKVTKPSSAAKVHLKTCTVEKPYICEICSKLFTLKGNLNTHKLVHLSEKPYKCEICSKQYTQLSSLKDHMTVHTGERPYKCEICSKLFTLKGNLNTHKLVHLSEKPYKCEICSKQYTQLSSLKDHMTVHTGERPYKCEICSKQFTQITNLNTHVKCHSGKKPYKCEICSKQFTQLSSLKDHMRIHTGEKPYKCEICSKQFSQRSTLIYHMRVHTGEKPYECEICSKQFTAKSSLNDHMRIHSGEKPYKCEICSKQFNLISNLNAHKRLHTSERPYKCEICSKQFKQLNGLNYHMIRHTGEKPYECEICNKRFATKHYLKLHMRLHTSEKPYKCEICDKLFTQLSHLKQHMIVHTGERPYKCEICSKKFSQKGTLKYHMRVHTGEKPYECEICNKLFIQLINLKSHMQVHTGERPYKCEICNNLFTTKGSLNNHIIRIHTREKPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMJ2</accession>
    <name>A0ABM5KMJ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cGMP-dependent protein kinase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511383.1">
        <property type="nucleotide sequence ID" value="XM_050655426.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655426.1">
        <property type="protein sequence ID" value="XP_050511383.1"/>
        <property type="gene ID" value="LOC114327714"/>
    </dbReference>
    <dbReference type="GeneID" id="114327714"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21930">
        <property type="entry name" value="IPD_PPP1R12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017401">
        <property type="entry name" value="MYPT1/MYPT2/Mbs85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038141">
        <property type="entry name" value="PP1_12ABC_vert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="9">
        <location>
            <begin position="789"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="794"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="457"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="888" mass="98708" checksum="9ED9352ED2FBA7DB" modified="2025-10-08" version="1">MSLETRSNSALFKRADQLKRWEESDTNREPVSPKQKTRKIKFSSGCVFLAACAAGDKKEVLELLHKGADINTANVDGLTALHQACIDDNLDMVEFLVENGADVNRGDNEGWTPLHATASCGFLSIAKYLIEKGAHVAAVNNDGQLALDIAESQKMEGLLREEIEDRGIDCEAARNEEELVMLRDAKDWLATKSSLVNVPHPKNGATPLHVACAKGYADVIKILLQCGADIDAQDVDGWTPLHAAAHWGQKETCQILAESLADMEAKNFVGQTAFDLCDTDMLSTLEDLRKKQNKEDVFNRRMAKKRADINDRNLESETPTKVKKVELEGTKVIRNIEMDVSSESESGSETESESSSESESESPDDEKKNNLNANNEITTNTTVPQKIVEDKEDVTLRKKPYTKQNSDLSPTKLNSTNNLTNSTESIKIEPEVTLRKPPIVQNEKPTKKEDNDTPVSTAATTNTTTNISQEKTSPVTSPQPTTNNQQQLRSGLKLQMPPPPTTTVTAPTPVTNSSTPSTPTTPGGTRLQMLKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLEEIKSAEQLVKQKNQPGGGNEEKPGANGDSPNGIVVTATITTGTPTVITTRESEEPPAIHERRPSWRLRVDNGTSKFLLEDASKPSDPPNTPSIIRRTIASIQRPSSAPLETADTTITLPLRKPKSVEEKDQDKENDIRNAQATLATQAAIQRRRRPKRRSTGVVSFDNVDDLEQEKDSSSGKDCDDTTKMNHLESGTDRSSRSRIGSSSDIRNENGELDYKKLYEQQLAENDRLKDKLRKSDEELRETKQTLEKINLVTSKNSLSELEKRERRAMERKLSEMEEELKQLQKLKAENERLKADNRSLTRVINKLTNSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQS1</accession>
    <name>A0ABM5KQS1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512537.1">
        <property type="nucleotide sequence ID" value="XM_050656580.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656580.1">
        <property type="protein sequence ID" value="XP_050512537.1"/>
        <property type="gene ID" value="LOC114332957"/>
    </dbReference>
    <dbReference type="GeneID" id="114332957"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044951281" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="25"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="630" mass="72236" checksum="55814E5CFC4E0C5D" modified="2025-10-08" version="1">MSCLNIQHFVKLLLLLACITLSHQFYVPGMAPTDFKKGDPIEVRAVKMTSIHTQLPYEYYSLPFCLPKGGSENIQYKSENLGEVLRGDRIVNTPYVVKMAEYTPCTLLCNSPGNPINWSVRESQVVVDRIQHEYFVHLLVDNLPAAIDVFNPETNELQVEHGYRLGNTVGDRSFINNHLKLRFLYHNPQPDVYRIVGFQISAKSIHMDELKFNGNTCDLTSKHKSQVVDPVSGTKLYFTYEVEWKESSVSWASRWDTYLAMTDAQIHWFSIINSIVVIFFLSGILTMIMVRTLRRDIAKYNADESYDETIEETGWKLVHGDVFRPPRNSRLFAALVGSGIQIFLMSLITIFFAMLGMLSPASRGALTTAAITFYMIHGAVAGYLSARLYKTMKGREWKRAAFLTAVLYPAIVGGTCFFLNFFIWGKASSGAVPFSAMINLLLMWVFVSLPLVYLGYYFGYRKQPYQHPVRTNQIPRQVPEQHWYMNPILCTLMAGILPFGAVFIELVFIFTAIWKNQFYYLFGFLFLVFVILIISCSQISIVMVYFQLCGEDYHWWWRSFIVSGGSALYILGYSLFYFMTVLEITEFIPTLLYISYTGLMVFTFWLLTGSIGFFAAYAFVRKIYAAVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQV8</accession>
    <name>A0ABM5KQV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512577.1">
        <property type="nucleotide sequence ID" value="XM_050656620.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656620.1">
        <property type="protein sequence ID" value="XP_050512577.1"/>
        <property type="gene ID" value="LOC114325222"/>
    </dbReference>
    <dbReference type="GeneID" id="114325222"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="4"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="542"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="792" mass="90486" checksum="DE129E6B32A0F0AD" modified="2025-10-08" version="1">MAENVKVIVRCRPMNKTETQLNCQCVVKVNNCVVETWDPNDGPAFAKQFTFDSTYGQESTTEAIYNDICYPLVESVLEGYNATIFVYGQTGCGKSFTMEGIKAENSPQKGVISRAFEHIFEAISVTSGVKYLALVSYLEIYNEQIRDLLLPSDKPVGSLSLKETPNEGVTVPGLSLVPVHNAAECENLLNVGSKNRMIGATLMNQNSSRSHSIFSVSVEQISNLNNNENIRKGKLNLVDLAGSERQTKTGATGERLKEATKINLSLSALGNVISALVDGKAKHIPYRDSKLTRLLQDSLGGNTRTLMIACVSPSSRDYIETLSTLRYANRAKNIHNKPKVNEDPKDTILRQYQEEISRLKALLENKPTIINNDIEVEDLTMTPEEEINRNVPSTVANPDLDSKRDKLLEQYQQEMKKLKSLHENEKIEKENIIKQIQKIKEEYDENIKKLNTEISVNKKKEETSEDEILKRMEALKASMIGGEKANDYELSERRKRKKQAAEERANVIAHLLAKIEMNEDRELLHNQYRDISQELHLKTDVLRKYRHKVKIMEKEISDIQSEFESERQDYLETIRKQERNNKLISQISDKLVGTLKKECNYSDLEAIKEQAIWLEDSQKYRLPDLVIPRTRLPPAGRTYDIQTAPGRLESDEDMREEETSVNHSLLKQRMDGIERENIISNYFQPPTKRVNELLRQSAKLDAATVIQTWKGRNGRVTFPEFARRNKSTEDSDRRSSPKKKHIFNGNGYGPNLWLNGHTTHHHDHNIKKPFRLEALPNIVKNHTGRLNTLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRU2</accession>
    <name>A0ABM5KRU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512903.1">
        <property type="nucleotide sequence ID" value="XM_050656946.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656946.1">
        <property type="protein sequence ID" value="XP_050512903.1"/>
        <property type="gene ID" value="LOC114345470"/>
    </dbReference>
    <dbReference type="GeneID" id="114345470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11391">
        <property type="entry name" value="bHLH_PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="358"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="620" mass="70598" checksum="49818DFE3C26C9BC" modified="2025-10-08" version="1">MDIKTAKENCKSAKASMTRIQKWVNSKLNSETNLFIVENKMSLLKDAFDKFSAYQDIIDLATPDTQEPVDRSLQEDLFSELSARLAENMNPQKHRVVIDSTQVLVNNKTRNAEIIISPTLSAFDLPVNDSQCFHFSNSREQRNKAEKQRRDRLNSYIGELASLVPMVARSAKRLDKTSILRLTATHLRIKQLLNNSRIVPNMGFPRHIDQILLEQLIYEQMGGFLLIVLANGKIVFVSSTVENLLGHLQTDLMGQSLFNITSPDDQDRLKIFLQCEGDIEQEWRKCFNIKLKRAGPRSETSVYEQVRMMGMHRQGTPTGIHQNSMLSSSSSSSSSSSSSSSSVNADDILIFFAKICRPEPFIERLIEASKEEYVTRHLIDGRIIDCDQRISIIAGYMTEEVLSHSAFLYMHRDDVRWVMIALRQMYDRGEMRGWSCYRLQSRNGQFIFLRTNGFLEIDDQGIVESFICVNTLVSEMEGMQLIDDMKKRYSALCSLEVSNLTPPPSNDSIDIVEDPAQVEQAVAHLVANLPSPSAEEAHLNIPSPLIHTENQDCTLSTTDCTASMQKYHIKRPKRPPSNDGQREICGYKRHKPYTGVKPEVKKEPETSIYQQDQLLRHNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSG2</accession>
    <name>A0ABM5KSG2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513123.1">
        <property type="nucleotide sequence ID" value="XM_050657166.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657166.1">
        <property type="protein sequence ID" value="XP_050513123.1"/>
        <property type="gene ID" value="LOC126888793"/>
    </dbReference>
    <dbReference type="GeneID" id="126888793"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046733345" evidence="2">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="265" mass="29595" checksum="39957BF8919D1D9F" modified="2025-10-08" version="1">MKFLGVSISFLLLIKYARSGFDEGQPCSDKNTAYLTDELKILPEILIYCVDVTEIKIKVVGNDNQDIAFSNISQTAEIIHSDANGISVYKNTNTNTNTNTNKNTNSNTDTATNANAKTNININDNKNKNLNINKNKNTFTYTNANKKTNTNTNENININENSNENTNTNINTDTDNTITNKNTNINSNTNKNTNINKNIDKHADKNTTTNTNANTNTNKNKNTNINTDIYTKNTNKNENKNENTNENKNENSNENSIGPKIKLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT77</accession>
    <name>A0ABM5KT77_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513398.1">
        <property type="nucleotide sequence ID" value="XM_050657441.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657441.1">
        <property type="protein sequence ID" value="XP_050513398.1"/>
        <property type="gene ID" value="LOC114342003"/>
    </dbReference>
    <dbReference type="GeneID" id="114342003"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="582" mass="67850" checksum="C3E5C95220EBFA63" modified="2025-10-08" version="1">MFPYTHFYNENAFECSDFSSGSDDMVTCDPDPCLKSNHPAHIEESSRYHFKNQSQYVPVTDSEEYRCCDYKKKQLTKGKFGLAYVIETPKKKITTPTGWQVEFEDTPSRIMQHCDKMERWVNCPPLGDYSSRECPDTCAEYIKGSLKQNKHRYGDDNLLQDYSRNNVSNGDQFCTMCDRCREVNTMYDTPKMAYYKKSNKTANKIRKSNGQIPQSCITCQNLPLDRQHQDRRPNFYDDVDPYHVNDSYRENRYYNEAACSKNYCNHYNRRPPTNKVLKNADVDLNCTDHLRRGDDLDYVPKKDKIKHSVTNNQTQCKRSNEEQQCKNVCQGLCQPPINIITICDKRVDKDKDTEIKTVLHSVETNTFVDLRCHGKETREEVKPLYVDKAAQGMSNSNVLYNKEKVVSPPTKKLSTPENVSTGILPELKKKFKEQNERVEKRKDELKPGDITDIIYEKLEQELDSRNQKENTPIKPDDIANLLYEKLEEELDSKNKKEIRQTEIEPPNKDKTDEFKTLNYKKLTKKEIFTDDLTPLQKIKLALKIQKREILESKLAQNMPRAPENAAILAQEEVIKIVEPLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV41</accession>
    <name>A0ABM5KV41_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cathepsin L-like proteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514055.1">
        <property type="nucleotide sequence ID" value="XM_050658098.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658098.1">
        <property type="protein sequence ID" value="XP_050514055.1"/>
        <property type="gene ID" value="LOC114325524"/>
    </dbReference>
    <dbReference type="GeneID" id="114325524"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045198125" description="Cathepsin L-like proteinase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36127" checksum="0401059F6CDC9D97" modified="2025-10-08" version="1">MKFLILVATLAITANALSNHDQWAQFKVKHSKNYNTFREEQIRFQVFSSNLLKIAEHNARYEKGEETYFMAVNRFADLTSEEYEAMLGLQISSMSKPNITSSFVADPEEPAPDSIDWREKGAVTPVRNQHYPHQCGSCWAHSAAAALESHRFINENKLEVLSVQEIMDCSRDYGNAGCNGGWMDSALEYVKDHGICAESSYEYTAQNGDTCKTCEKVIHTFKEVVEVGPSEQLIKEAVGTVGPVTVAVDASKWQLYAGGIFDGNCGYTVNHGVLVVGYGQENNKDFWLIKNSHGAEFGENGYIRLARGKDLCNITFLINYPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWM2</accession>
    <name>A0ABM5KWM2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 12-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514588.1">
        <property type="nucleotide sequence ID" value="XM_050658631.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658631.1">
        <property type="protein sequence ID" value="XP_050514588.1"/>
        <property type="gene ID" value="LOC114342085"/>
    </dbReference>
    <dbReference type="GeneID" id="114342085"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF73">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35294" checksum="9BC80492A99550A0" modified="2025-10-08" version="1">MGMLFSVSCNSNNRLNGKTALITGANSGIGKTTAKDFYIRGARVILACRDIEKAKTTICTIQQQCESKENLGELEAVELDLSSLQSVRECAKAILEKEKQINILINNAGVMMCPFSRTEDGYETQFATNHLGHFLLTLLLLPRIIKSAPARIINVSSSAHSFTPIDFSDINWEKRTYSPMGAYSQSKLSNILFTKELATRLKENNIQGVNIYSLHPGVIRTNLGRHVSKKIYFPGLHWLWRNVAPYIIKNPEQGAQTQIYCAVDEKCANETGLYYSNCKVIEPSADAKNEQFAKQLWEISLNMVGLDENFNPFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX50</accession>
    <name>A0ABM5KX50_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514773.1">
        <property type="nucleotide sequence ID" value="XM_050658816.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658816.1">
        <property type="protein sequence ID" value="XP_050514773.1"/>
        <property type="gene ID" value="LOC126890015"/>
    </dbReference>
    <dbReference type="GeneID" id="126890015"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="556" mass="65966" checksum="1A9D9647B0B7D6AA" modified="2025-10-08" version="1">MYLEGGHILIYSGVPNEKKAAAGVGCVIHKDRIKHIQTWESWTERILTVEMKDEGEENLTIITVYGPDENEKKEIKDKFWEDLNIAVENSKGNIFIIGDFNGRVGTKDMSTSDVIGKYGEEVRNNNGRRLIEFCELNSLIVTNTHYEHKNIHKFTRQGPRETEKSIIDYILIERNNRRALQDIRVRRGPEISSDHYLLEAKIKHRIEPQTRAAENRKKIESETIKNYKLRDKQIAQKYEELTNLKITNLMRPIQVSNLEQKWQLLKGILIETAREACEVYRKNNKTKQTSWWNDEIKNHVKMKKKMWEKYLGNKTEENYDRYKEERKKVRDMIKIEKEKTWIQFGQQMEYNSKENQKVFYRTMKNIRIDKPTRDTRIKNTDGTIIRDDQEIMERWKQHFQELLTSNEVNREENNEENEERTEQEENTDEITNEEIETAIKKLKNGKSPGHDRITPEMLKYMGLEGRKLLREICNEAWKKEEIPSDREMGVILPIHKKGDIKEYNNYRGITLLCTALKVYETVLEQKLKNIIETTLEEAQSGFRKGRGVQDHIQSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX87</accession>
    <name>A0ABM5KX87_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich adhesin for platelets</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514813.1">
        <property type="nucleotide sequence ID" value="XM_050658856.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658856.1">
        <property type="protein sequence ID" value="XP_050514813.1"/>
        <property type="gene ID" value="LOC126890038"/>
    </dbReference>
    <dbReference type="GeneID" id="126890038"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="949"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="910"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117846" checksum="8EBA6DB3885691B4" modified="2025-10-08" version="1">MKRLKNNSSEKNRTSPARPMGQCMSRKAAGAFAASAAVSQNRPTKIQKHQKFQSPDDDNKPRSLLITQDSNKQHQQRFVQTTTNVGTAATTKGVAMSFGFKRRQTAPSIAANATAARRLANNQGSIDGTTTTESIDRNGNDSRDTDALTSNAAPTGRSTPRLLPPKKEANATKVSRFGFRHTQTSRLNKVADVNNAGDITNQNKNNNFVKKPIALARTVVPTDNNNRNRMYRVDPPPPQIGKFTLQSTQLPRPEPIRVIETKSAKTVANNNRRVAGMYQQHPEETSSKDGSLTEDSGVGSHFSSYVGETDVVLRGYDHLDSSPTFGARRRKNSHHKPRNLEVVVTGTNTFDVRDLEDSNDSCDSVSAPPLPQLPSAFHSTPEHKNNSYHPSGLVRDRTVEYQRNLDRNNRLRKISKTSSEGFSDDYGEEEKTYRDLFRSEKTFIRPSGPQPNFFKSRTTQLRDDSSPPSSDEQEWLHGGEAMADDVSFSLSSSDESKDKNHEVAPVQMPISATVINASLHSLMNSSLSKAFATSTKNVMLTIEDPKFAAVASNTGTLLDDETLLSPVDSVMSFSESEELRRKLNRSSSNSKDINEKLTPPSPGTPTNASNSLSISDDNDNLNNSGKDDFLIDDEIADQPALMFEDRTHPLNNDISSETLMDSTPKSRRRIPSGVENSPLSTKNKKFSINRTGSLDTLSPCESIASDDLMMDFGYSQSSGLDDCETHSSGYPSLNETLTPQRQETSDIYKELREWNSENHTPHRGTEKHKKSTTASRTRLLSSRVSTPNSTVDSPKTLGRVSRPSATSSPVRYNRVANLSSACGYDSDDSIRLDRASHTAVKQDIVGIKTMLLKLRRVLNETVEEELLRSETHNPFESQHLTNGIFNSLCPDNDVSDDGSGQNEAKVISELAELRRQVLFLQGQLEDREKTVQNLQEQMVRLAEDNYHANSAPASTTCESSTCNAATQTERMRPISAGPSLLGGSPVDGSAGSLVSVTEFLSPTSPRTARKSRPPSVTPPGTSDSTPSKKIPSRLWRQPGEPPSPQRYAFISSSTSSIPRRAHSRTRTPASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXI0</accession>
    <name>A0ABM5KXI0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514882.1">
        <property type="nucleotide sequence ID" value="XM_050658925.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658925.1">
        <property type="protein sequence ID" value="XP_050514882.1"/>
        <property type="gene ID" value="LOC126890085"/>
    </dbReference>
    <dbReference type="GeneID" id="126890085"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="160"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="363" mass="41950" checksum="8F3B8091B7DD1D10" modified="2025-10-08" version="1">MLPLYQVMFAEIEEQNRRHDILEQNIERRIMREESDPFSFSDNHFISLYRLTKDMAHYLIDQLLPHMNNSLHPNAVDPRTRIFAALFFFANGSYQRVIGHSHAERMGQTTVSKCIKEVSDLIVHNLSNTWIEFPVTAEAKLAIKTGFMETSQFPGVIGAIDCTHVAILAPRIEEHNYINRKGYHSKNIQLICDSKLVILNVNPRYAGASHDAYIWRRSAIRQELHDCYEAGDTNSWLLGDSGYPLEPWLMTPVQNAADGTPERRYNFRHASARNVIERCNGVLKNRFRCLLGERRLRYDPEKVGTIAVACCVLHNICVKGRLDENDLSEDFLDNQVPEEIEIRANEEDSGTRTRQLLIERYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXL1</accession>
    <name>A0ABM5KXL1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514925.1">
        <property type="nucleotide sequence ID" value="XM_050658968.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658968.1">
        <property type="protein sequence ID" value="XP_050514925.1"/>
        <property type="gene ID" value="LOC126890121"/>
    </dbReference>
    <dbReference type="GeneID" id="126890121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045040261" evidence="1">
        <location>
            <begin position="23"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="943" mass="100269" checksum="CF2D4ABFD58D4933" modified="2025-10-08" version="1">MLAGRIVSLFGLLLVTCSFVSPAPTKCKCRKIIVTPSEQSCLLGHLIQILTHLVNNQQHPVCAKDFIRQLEEICEEEKNCHCCCQTRESECETTESDCSTTESECETTECDCCTTESDCCTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTICCSTTTESCDTTTTCCTTTTEHPCDTTTICCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTKPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCTTTTEHPCDTTTICCSTTTESCDTTTTCCTTTTEHPCDTTTICCSTTTEPCDTTTTCCTTTTEHPCDTTTTCCSTTTEPCDTTTTCCPTTTTEHPCDSTTPCCSTTTEPCDKTTTCCPTTTTEHPCDSTTPCCSTTTEPCDKTTTCCTTTTEHPCDTTTRCCSTTTEPCDTTTTCCTTEPPCETTEPPCPETTACCTVPTPHSCGLTLDPCCEHRRSGLYFIPVLKVDGVPAMSHHELKDYILNLFNSLNFGGHHHHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY39</accession>
    <name>A0ABM5KY39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription termination factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515092.1">
        <property type="nucleotide sequence ID" value="XM_050659135.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659135.1">
        <property type="protein sequence ID" value="XP_050515092.1"/>
        <property type="gene ID" value="LOC126890278"/>
    </dbReference>
    <dbReference type="GeneID" id="126890278"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="359"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="769"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="107401" checksum="6F0A63DC70A7403A" modified="2025-10-08" version="1">MTVSDPNSAKNNKEKSFKASKKDNVISSDSEEESFRGTKKNNVIGSSEEETSRQTEKNYVIIPDSEEKISREVEKNNAIISDSEEDTFRETDENMSLDRKESIEPSYRTSKFNDACTSREVTQIILSSSEEETDDVIGVSDDELLSKTKPKVTQIILSSSEEDSDDIIEDSDGESVHKTKMKRPTLLEMFKKEPKIQSKIEPKTEPKIEVLSSEFFEVSPRQYQEQRQMVQRLRQAELLMKALDLELLPDNEEDDTLSKMKIPQEDEKDEVQITHTSVPPKTLSWNDIEKGTGKVRPNTKGKQAMSTYNAQKALTVDRLQQLHGSLKSCPKEDDHADPPRGLTVDLMPHQRRALSWLMWRENQKPSGGILADDMGLGKTLTMISLMLKCNELEKPDFDEENEEEGVQPKKYNGGTLIVCPASLLNQWSRELEIRTTRGLASCEIYHGPRREKEAKRLAKYDMVVTTYSIVNNECENDGAVFKVKWSRIVIDEAHQIRNHKSQTFDACCRLSAKSRWALTGTPVQNKELDMFALLKFLRCTPFDNLPVWKRWIGDKRTGGTERLHTVISSLMXRRTKPELIEKGLLNAMPERTWELISVYLTKSERDVYSKILICSRTLFAQFLHQRAEKNQDARDYQLDTLEGPNGSNKEYFLMREKLLRLNELRDIKQHEILVLLLRLRQICNHPSLITGMLEEGLELAGDEENAHDIERALDLLDQLNKLTINDTEQPGTSEVADDLSEEDTSLKQVVHNVLSPSDPVFSKTWSSSKVEAVIKLLNEKVLTTNDDKAVIVSQWPSFLNLIAYHLEKLNVKYDQLDGSVPVIKRMDMVNKLNNPKDDLRVMLLSLTAGGVGLNLVGANHLILLDLHWNPQLENQAQDRIYRVGQQKPVFVYKFMAEDTVEKKILDLQEKKLGIANALLTGTVQAAKNKLSIDDLKLLFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZI6</accession>
    <name>A0ABM5KZI6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein 8-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515601.1">
        <property type="nucleotide sequence ID" value="XM_050659644.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515602.1">
        <property type="nucleotide sequence ID" value="XM_050659645.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659644.1">
        <property type="protein sequence ID" value="XP_050515601.1"/>
        <property type="gene ID" value="LOC126890581"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659645.1">
        <property type="protein sequence ID" value="XP_050515602.1"/>
        <property type="gene ID" value="LOC126890581"/>
    </dbReference>
    <dbReference type="GeneID" id="126890581"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028547" description="Cuticle protein 8-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19406" checksum="B2634F2E463E8E6B" modified="2025-10-08" version="1">MFSKILSVLALTAVAQAGVLDYSHGHGDATSYSSTNLGVSGHGNGYPAPVLSHAYAAPVLSHAYAAPVAHGYSTPLLAPGHSAHQDEHYNVHPKYEFNYGVQDGHTGDHKTQHEVRDGDVVKGSYTVAEPDGTLRTVHYTADDHNGFNAVVEKSGHPVHQVPAHGHGKVLLAPVAHNAPLYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L052</accession>
    <name>A0ABM5L052_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515819.1">
        <property type="nucleotide sequence ID" value="XM_050659862.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659862.1">
        <property type="protein sequence ID" value="XP_050515819.1"/>
        <property type="gene ID" value="LOC126890701"/>
    </dbReference>
    <dbReference type="GeneID" id="126890701"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="570" mass="65330" checksum="E7CD3591D8BBBB88" modified="2025-10-08" version="1">MEFKIEIKEELVEYDQRHTESPLSTSINLGHLKSEPEVNSALTIKAGVKEEFGDGDPRYIQSQPSSSLDPKGLKNESDEYNLGFLEKKNTSETMKTKLVRSSNKEQHISQPVENKSFKCEICLKQFCQAIRLKNHLRLHSGFLEKKNTSETMKTKLLRSSNKEEHNNISQLVEKKSFKCEICFKLFNTASNLKTHLRVHTGEKPYKCVICCKQFSGAGSLKTHLRVHTGEKPYKCVICCKQFSGAGSLKTHLRVHTGEKPYKCEICFKQFSQNGDLKTHLRVHTGEKPYKCEICFKQFSEACSLKTHLRVHTGEKPYKCEICCKQFREAGSLKTHLRVHTGEKPYKCEICFKSFITTSNLKTHLRSHTGEKPHRCEICLTQFTQKINMERHLKVHTDKITCKCDVCFKEYTGTDSLNSHIKLHTGAVPMCKICSKNFSTASNLKKHLKLHTGEKPFNCDICFKQFTQASNLTAHLKLHTGEKPHKCQICFKQFSQPSHLTVHLRLHTGEKPYKCEICLKQFSVAVHLKIHSRTHTGEKPYKCKICTKQFTVGGSLKIHIMKKHTGEKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L149</accession>
    <name>A0ABM5L149_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516164.1">
        <property type="nucleotide sequence ID" value="XM_050660207.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660207.1">
        <property type="protein sequence ID" value="XP_050516164.1"/>
        <property type="gene ID" value="LOC126891028"/>
    </dbReference>
    <dbReference type="GeneID" id="126891028"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="48256" checksum="C9B68704A0A3D7B1" modified="2025-10-08" version="1">MPKRHYIRRQVHQQEPHIFDLYQKPRFDDTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFAIHDTLLEIKGSIKKAGNGTVSLAPNAGSFLFDTCTYIQSSHDMEIVRDPGVVSTIRSLLCYTPEDSKFLSTAGWNYPNYPHLTGDAFSLLIPIKHIFNIFNDYTKLTYGRQVFRFVRARNDKDCIVVQEPTGSTTVTTVSLTIASMELKVKHVFPNDDVKIELMIPIKNNTPITIPFRKWEPNELPSLTAGSRREIWSVKTTSAVERPRYVIVAFQTSKRDDIHADPTLFDHIRMSSVRVVINGDYWPNERMQLDFTKNDYAIAHYNYTEFFPSYARSLTKHPILDYSAFKRYALFVFDCSKQDDTSFRSGTVDVKLEIEADEGVPAGTRAYCLIVHDSLLEYFPLTEVVKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1E6</accession>
    <name>A0ABM5L1E6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516262.1">
        <property type="nucleotide sequence ID" value="XM_050660305.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660305.1">
        <property type="protein sequence ID" value="XP_050516262.1"/>
        <property type="gene ID" value="LOC126891124"/>
    </dbReference>
    <dbReference type="GeneID" id="126891124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="275" mass="30999" checksum="C2CAE3AC8A671908" modified="2025-10-08" version="1">MERIIELVRKYPILYDLSHEDYKNVRKKDKIWTRIGEEIGENDVDTQESEAFPNIESPENILTDENSAVQKPTCSKNLLTTQTDDSQNKIQPSSSKPTRNEATRVTLSNETPSTGRTNRKRNSEPSTSVKDMISYFESKKRVVHDATDQVFLAHASTVKSFSPRRQIETKMKIAQVIMEQELLQLEESSLNSHQSRAESTDTYQNPSSVGSISVVSLPSPNDTALPKQSNTSGFYEVNCENNYITLHNLAQSCNQAASHNPSVSNYVNSFDPYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1L6</accession>
    <name>A0ABM5L1L6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516328.1">
        <property type="nucleotide sequence ID" value="XM_050660371.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660371.1">
        <property type="protein sequence ID" value="XP_050516328.1"/>
        <property type="gene ID" value="LOC126891188"/>
    </dbReference>
    <dbReference type="GeneID" id="126891188"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="150303" checksum="28871ED25193D385" modified="2025-10-08" version="1">MLAKLIHLIGTILELISDNYNVEKLRKGLVECKKAIKMIHDRMRFAKTIGEKHHLEAQMRQVKTLRNQLKAEQKKGAGLKTLPETAKRRVQWDDSVSTFNSRIQTGVISNLKHKDPGSFLVDCKALFKRRIHNVLKNNAAVKVNIAFGGEFEIAQGEKMINETKYFTTSNSAIYRDTNLDEWFKKKVVEPISRDLEEFQERDSGWALKSVVNLGVNINKFTPQLGSSYIELPPQIKRKQACINVKNDDEACFAWAVISALYPCRSNSDLMSSYPHYSQVLKLKGIQWPMTFKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTKNKKDKHVNMLLIQDNYDDQGPVRYHYVWIKNLSRLLSKQLSKCDGTKYFCDGCLHYFRSQEKMNVHKTCCNGRSDVICDRCLQPFSSYTQLEAHINDCERINETAIKMPEESQKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVGYYFKCSYDNSLSFYKSYRGKDCMKWFADELNQLAEDVYTVFMCPFDINMTFQQESDFQSATHCHICEQRFSPSDKKIRDHNHLIPENNYRFAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVTDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSQYVFLPEEQFNLLTAKGIMPYDYIDSFDRFIETCLPSIESFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLADVFERFRSSCLETYNLDPAHYFTLPGFTWDAMLKYTKEELELLTDPDMHLFVERGIRGGLSQVCSKRRVHANNKYMVSYDPSKTDSYLMYFDVNNQYGWAMSQYLPFGGFEWTDTNIDVLSIPDDSSEGCILEVDLEYPQHLHDRHKDIPFCPQSLNPKTMKPPKRPRELTKLMATLHDKERYVIHYRALKQALAHGLILKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTLECVRRRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLIAVEMHRAEIWLVKPIYVGMSILDLAKTTIYDFQYGYLASRFGENFSTCYTDTDSVIVEIREKDPYEAMIYDCYKYFDTSDYPKDNIYNIPLVNKKVLGIMKDENNGCIMTDYIGLRSKLYTTKAATTDNDIEKLRGKLKEQEYEDDEIDNIIRNYGVTKKAKGVKKSVVNTKITFEDYVECLDTFTTKTATQNLIRSDKHQVYSITQSKIALSSNDDKRQHIQGSYDTLPFGHYLIDTLEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2F5</accession>
    <name>A0ABM5L2F5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516618.1">
        <property type="nucleotide sequence ID" value="XM_050660661.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660661.1">
        <property type="protein sequence ID" value="XP_050516618.1"/>
        <property type="gene ID" value="LOC126891484"/>
    </dbReference>
    <dbReference type="GeneID" id="126891484"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="258" mass="29150" checksum="982A76BC80C941D4" modified="2025-10-08" version="1">MENNLLTELLTVDGDFQNFTRLPFEKFVELHEKIAPLITKQETHMRSSISSKLRLAVTLRYLASGNSYKSLEFLSRISRITIGNFVPEVCHAIVIVLKDKFLKVPSSKEEWQKISSEFKEKWHFPHAIGALDGKHVAIRAPANEGSYYYNYKGFHSLVLLALVDANYKFIYVDCGGNGRISDGGVYRNSSLYAAVNVNNVLQIPPPEPLPGKRNPLPYCIIVYCDRSGMIHNEEKVTVKPRLPNSRCDNSELLCETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L415</accession>
    <name>A0ABM5L415_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517173.1">
        <property type="nucleotide sequence ID" value="XM_050661216.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661216.1">
        <property type="protein sequence ID" value="XP_050517173.1"/>
        <property type="gene ID" value="LOC126891879"/>
    </dbReference>
    <dbReference type="GeneID" id="126891879"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
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            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517173.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="586" mass="68403" checksum="B98B8644B9764A87" modified="2025-10-08" version="1">MDVKQEVTEETGKVKVEIYNEVDDGFLDSCKIEIQEEPKKESIHDTFVYSDSQEFPTKIEVDPDESQLRPAEEIDEKGYLQDEDKMEIGGKLIKDLSYEGNDTSRQTEEKTLNKNMKVVTGRRPNKCEICSKQFSQRHHLKRHLRVHTGEKRYKCDICFKQFSQGSTLKTHLRVHTGEKPYKCEICYKQFTKASNLKEHLRVHTGDKPHKCGICFKRFSRAGNLKAHLEVHTGIKNYKCEICFKQFSQASDLKRHLRVHTGEKPYRCEICFKQFSQARILKKHLRIHTGEKPYQCEICSKQFSEAGSLKKHLRVHTGDKPHKCGICFKRFSRAGNLKAHLEVHTGIKNYKCEICFKQFSQASDLKRHLRVHTGEKPYRCEICFKQFSQARILKKHLRIHTGEKPYQCEICSKQFSEAGSLKKHLRVHTGEKPYKCEICFKQFSKSSSLKAHLRVHTGEKTHKCEIFYKQFNKASNLKAHLRVHTGDKPHKCEICFKQFSQASDLKRHLRVHTGEKPYKCEICSKQFSEAGSLKKHLRVHTGEKPYKCEICFKHFSTNNLKAHLRVHTGEKPYQCEIVLSNSVKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L517</accession>
    <name>A0ABM5L517_DIAVI</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="RefSeq" id="XP_050517534.1">
        <property type="nucleotide sequence ID" value="XM_050661577.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050661577.1">
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        <property type="component" value="Unplaced"/>
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    <dbReference type="InterPro" id="IPR036236">
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    <dbReference type="InterPro" id="IPR013087">
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    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR24379">
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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        <property type="match status" value="10"/>
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    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
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    <dbReference type="SMART" id="SM00355">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6C7</accession>
    <name>A0ABM5L6C7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517990.1">
        <property type="nucleotide sequence ID" value="XM_050662033.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662033.1">
        <property type="protein sequence ID" value="XP_050517990.1"/>
        <property type="gene ID" value="LOC126892489"/>
    </dbReference>
    <dbReference type="GeneID" id="126892489"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
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    </dbReference>
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            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
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            <begin position="152"/>
            <end position="245"/>
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            <begin position="120"/>
            <end position="129"/>
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            <begin position="156"/>
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        </location>
    </feature>
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            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="401" mass="46348" checksum="F29DAAFD24B4ED00" modified="2025-10-08" version="1">MRILENQSNDTAGSPISIATVESPSTLYTNQQYYRDLGELRSLHSPVHQEQQYCQLETPIEQQFSQHYNQYYDLPIPTSVGLLVPEAEQYRQFPNNYLGYCSPLDNVIDLQTSTEQPRFQQRDEAKDSHNPTPSVVNLATPVLQEQVLQHQDDITRPSTSTGKLLPTISQQTDENSDPYATYGSSDVDFNPNDFDSSSSSDEEGDHHSSIVNQQDALVSEEKIPDITKSRKRKRNPDNWRRNRIKKLRNSGKAYVNWKSKQVSERIMKPPCPITCRLKCQTKFQEKHRVQIFQDFWKLGDINYQREFVLRNLTVKPTKHPRKKKDAVELPESDTCESRIKLSYFYTFPQENCPVNRIKVCQTFFLNTLGISHQIVKTVVKKTHHSNSISPEADLRGKVHTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7R0</accession>
    <name>A0ABM5L7R0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="6">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050518478.1">
        <property type="nucleotide sequence ID" value="XM_050662521.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662521.1">
        <property type="protein sequence ID" value="XP_050518478.1"/>
        <property type="gene ID" value="LOC114346921"/>
    </dbReference>
    <dbReference type="GeneID" id="114346921"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046065289" description="Superoxide dismutase [Cu-Zn]" evidence="7">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="252"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="391" mass="41671" checksum="73DEBD7FF18815DC" modified="2025-10-08" version="1">MFKIALCAAILAIAYAEDGIVYLMDPTGKSGVTGTVRFLKLPSGINVIGDIRGLTPGKHGFHIHQEGNIQPSCLAAGGHFNPFNKQHGGPEDSDRHVGDLGNIEADQNGVAVFDFLDTKISFDGMTSILGRSAVVHEKVDDLGKGGHPDSLKTGNAGGRLACGVVGVVTTQVDSFYTVALLSLALDKNWVCCCVSTVFFILSTRVVVSLSNLLVNNCSKMIKNALFAAILAIAYAKQLGIVYLFDPMKKTGVTGDVRFEQKEDGILVAGLIKGLRPYNRHGLHVHQEGNISPSCLSAGGHFNPTNNSHGGPEDEERHTGDFGNIKADVYGFGQVYFIDKRITFQGNTSIIGRSLVVHTSEDNLGHKTHTDSKITGNAGGRLACGVIGIWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L891</accession>
    <name>A0ABM5L891_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050518655.1">
        <property type="nucleotide sequence ID" value="XM_050662698.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662698.1">
        <property type="protein sequence ID" value="XP_050518655.1"/>
        <property type="gene ID" value="LOC114339713"/>
    </dbReference>
    <dbReference type="GeneID" id="114339713"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF2">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046608591" description="alpha-1,2-Mannosidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="648"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="993" mass="112610" checksum="5B24C7160279AED2" modified="2025-10-08" version="1">MFYFENFFVSFLLSVVILTTQTCSSKEQKHMSSKERIQLREEARDMFYHAYNAYMYNAYPADELMPLSCAGRYRGISPNRGDIDDSLGNFSLTLIDTLDTLAIFGDLEEFEHAVKLVIKDVNFDNDVVVSVFETNIRVVGGLLSAHILSEYLQQRDGIMPWYKGELLNMAKDVGYRLLPAFNTTTGIPHSRVNMKYGLKSDRLESARETCTACAGSMILEMAALSRLTGEPIFEMKAQKAMDELWKMRHRSSDLMGTVLNVHSGDWVRRDSGVGAGIDSYYEYCLKAYILLGDNKYLNRFNRHYNAVMKYISQGPMLLDVHMHRPHTNSRNYMDALLAFWPGLQVLKGDIKPAVETHEMLYQVMQRHKFIPEAFTTDFQVHWGNHPLRPEFLESTYFLYIATGDPYYLEVGKNVLKSLQKYARVPCGYAAVNDVRTGKKEDRMDSFVLAETFKYLFLLFANKDDLILNLDEFLFTTEGHLLPLTLSGRTINGSKTVDMDIDGFEFDRTCPNTLRLFPESFRKPLQNMVDGMCPKRSQKRRLTASEFSAANLNHLKIIKDMGINIIALNDGRVQLLHTFSAARSAADAEEGLLFMQEMVELSKLQSQQPEPSAQAISIPVLGSKEDEQLIVLHAGPSQFGKNLKGNQHVTAQVVLVRPSRGCEPPQEPSALKGKIAIVDRGECMFVDKVRAMQKYGAIAAVILDNAPGSSAANSPMFSMSGDGNDDVKIPAVFLFTQEASKLLLAVNKDPQVEITIRELKDSDNFSQNEEESMFQKLKISVQEFLNKHTGIAFTKTVELGGFRANIGNNKVRITYEGDQQDFTPIKETTVNEQWSKIRKGLLKSILTSENKELLVPLNILRIYYQTLSGVSAKDVSKVDIVKQTEWLLEDLSKELKKKDDDLVQLESDPEITIITEMTETDKDALVNENENKRRKEISSFLEEEMNKIDEVFNKLKIKVNDDIIVGDLAKSVNQIKQEKIRNNKVKSKHSIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXY1</accession>
    <name>A0A6P7EXY1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">eIF-4F 25 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114324251</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127846.1">
        <property type="nucleotide sequence ID" value="XM_028272045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EXY1"/>
    <dbReference type="FunCoup" id="A0A6P7EXY1">
        <property type="interactions" value="1751"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272045.2">
        <property type="protein sequence ID" value="XP_028127846.1"/>
        <property type="gene ID" value="LOC114324251"/>
    </dbReference>
    <dbReference type="GeneID" id="114324251"/>
    <dbReference type="KEGG" id="dvv:114324251"/>
    <dbReference type="InParanoid" id="A0A6P7EXY1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028127846.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24572" checksum="0CA753EC6CF741C6" modified="2020-12-02" version="1">MSTNSLENEIDKNEQKNDNDLEIPMDFSIKHPLQNAWTLWYYENDRTQAWEKNQKEIATFQTVEDFWSLYNHIKPSSELRQGTDYSLFKKGIRPMWEDDANKRGGRWLLSLEKKQRNNDLDRYWLDIILCLIGEAFENSEEICGAVVNIRQKGDKIAVWTADAQNSHAVLEIGSKLKERLHIPSRVTLGYQLHKDTIQKTGSVSKYSYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F005</accession>
    <name>A0A6P7F005_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ecdysone-induced protein 74EF isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114324522</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128182.1">
        <property type="nucleotide sequence ID" value="XM_028272381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F005"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272381.2">
        <property type="protein sequence ID" value="XP_028128182.1"/>
        <property type="gene ID" value="LOC114324522"/>
    </dbReference>
    <dbReference type="GeneID" id="114324522"/>
    <dbReference type="KEGG" id="dvv:114324522"/>
    <dbReference type="CTD" id="39962"/>
    <dbReference type="InParanoid" id="A0A6P7F005"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000411">
        <property type="entry name" value="Ecdysone-induced protein 74EF isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="382"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028128182.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53895" checksum="B239FBACD164153B" modified="2020-12-02" version="1">MSLAMPFIDNDLLWSSDHDGKMVDISSCLQDASVAIGQQNAATGANGLGELSQSDLSSLVVPVMHDPNMADEDIFKHLSDTTAIEIESILRDISQTTYIKQEEPNSPHDESDAHSPSDQKSAQVLLEMRKYTIAAANPILAEKLATPTEQSLTQLCTSPSSRSQLAPLTPKLEKVDKEQNNYNQLHQLLSRQRTDLQHPSLCEYGRRKSVYPTTTGSLPPSPADSGVSDVDSSSSGHTSTDELKARLQPSIHSPVGTLFPRHPFSWNNTHHGQRPPNHMSQQFYQPFATNLDPYNSYLLQQHQVQQSHHMHHHTQSPFTTPSPPSPPIRHSIPTSVIQAATSSMYDDPYMLGFSPRKLKKVKKQKLGETGTVKRKSREGSTTYLWEFLLKLLQDREYCPRYIKWTNREKGVFKLVDSKAVSRLWGMHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYQFVEVPKDIVEIDCTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1T6</accession>
    <name>A0A6P7F1T6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114325420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325420</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129291.1">
        <property type="nucleotide sequence ID" value="XM_028273490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F1T6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273490.1">
        <property type="protein sequence ID" value="XP_028129291.1"/>
        <property type="gene ID" value="LOC114325420"/>
    </dbReference>
    <dbReference type="GeneID" id="114325420"/>
    <dbReference type="KEGG" id="dvv:114325420"/>
    <dbReference type="InParanoid" id="A0A6P7F1T6"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028373025" evidence="2">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129291.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="17734" checksum="35E6C6B436A5D43F" modified="2020-12-02" version="1">MKYLYLFFIAYIFAYVSGSQLKNQQHVCNCQKTLETIYADVLQQEKALNQTLIDISVLEIELRQLDDLLEGQEDKLIDISAELAALTVTKNYINRLLADGSQALQCIIDNLKEVCHDLHDDVDNDVDQQQSQIINILSVVMKVEDCKNGNSCPAAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3E8</accession>
    <name>A0A6P7F3E8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Zinc finger protein 131-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC114325508</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129371.1">
        <property type="nucleotide sequence ID" value="XM_028273570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129372.1">
        <property type="nucleotide sequence ID" value="XM_028273571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3E8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273570.2">
        <property type="protein sequence ID" value="XP_028129371.1"/>
        <property type="gene ID" value="LOC114325508"/>
    </dbReference>
    <dbReference type="GeneID" id="114325508"/>
    <dbReference type="KEGG" id="dvv:114325508"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF106">
        <property type="entry name" value="FI01104P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028129371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028129372.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36218" checksum="27762E3273DC93B3" modified="2020-12-02" version="1">MNSMDEAKQFAVTWSNHMNHVKQAFDNLLNNSDLTDVTLYVEGNKIGAHKMLLSACSNYFNNLFKDFPQEHPIIVLKGVRCRVLKDILKFIYSGEVSVDSSHFDNFLQTAEFLEISGLTNRQNVEECENVDTELINGSSSKSKRIRSRKKKIKMEVTEEGEADDGNAEWDDQDLTPVFTENLCDIQITQGSDEIEVNDIVVKNKRKIDEEDQQDLSSDDSVAGPNCTPKVEGHVQISVSSCSSAPTKSSRKSKFDNFFDIANDRQSAMCKLCFSEKKKIMKLSMSHRSTSGLSKHLRRAHRDEFNLLAENMVPDRFPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3V4</accession>
    <name>A0A6P7F3V4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger matrin-type protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114325625</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129532.1">
        <property type="nucleotide sequence ID" value="XM_028273731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3V4"/>
    <dbReference type="FunCoup" id="A0A6P7F3V4">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273731.2">
        <property type="protein sequence ID" value="XP_028129532.1"/>
        <property type="gene ID" value="LOC114325625"/>
    </dbReference>
    <dbReference type="GeneID" id="114325625"/>
    <dbReference type="KEGG" id="dvv:114325625"/>
    <dbReference type="InParanoid" id="A0A6P7F3V4"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028129532.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="20101" checksum="D0A3099AE1B51E98" modified="2020-12-02" version="1">MMGRRYYCDYCEKCFIDDLDARKKHLQSANHIKLRNMHYESCRDPETVLKEELLKIPCRRFSQGSCPFEGVCRFTHYSPEELCELRKQVENIQQMRRKQKEEVPPVPPLEKWIEHYEINNKDASDKVHLFWTYPENLENRNDLPPSLIKFRPEHFYDDNFEEWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6Y9</accession>
    <name>A0A6P7F6Y9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114325342</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114325342</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129200.1">
        <property type="nucleotide sequence ID" value="XM_028273399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6Y9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273399.2">
        <property type="protein sequence ID" value="XP_028129200.1"/>
        <property type="gene ID" value="LOC114325342"/>
    </dbReference>
    <dbReference type="GeneID" id="114325342"/>
    <dbReference type="KEGG" id="dvv:114325342"/>
    <dbReference type="CTD" id="55814"/>
    <dbReference type="InParanoid" id="A0A6P7F6Y9"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="461"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="526"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028129200.1"/>
        </source>
    </evidence>
    <sequence length="1058" mass="119633" checksum="3D14294A011D1A5D" modified="2020-12-02" version="1">MASRRSRIKGIANIPQRRKATNEENKLNLTESEAGENEKPSENKDAPLDNSNTGNSISNDAIEINLPKPEALTQIVKETFNNGVTNIKNEAQQNSKDCDKNLTPATEPPKPATEPPKPATEPPKPTNILKRKFIKAPVSLNAIKNRKKPYQESLEKGVDTQVNETVETNKNKVLGNFEQSSNNDLACTVNKEFIKNEEVSAAHDIQNQLPKEDNIGNLFQKPVPLFSNIQHSDTEYPLPPPSPNKANRSRIKAIPRLAQRKHSFSASESEDESRKINRIRNDSVCSTTSMVAEPITECFSPQRTRDPVFTTQVKKVVARSEQTRKLAEDRIDFYRRFGAKKPERHRLKMADLIFYNPESNPMTNEENIKNNEEPMEEMVDDPNGEAVDDPIKKDITKSDEENEMPVPQIKIGPSGEIILDEQSLVVERKEVQRQREEMEKTKILDADRMKTGYGIYKKHKRTKAWSHEETIMFYTVLNTVGTDFMAVTEFFPNRSRRDVKAKFKKEEKINRHLIDKALGEPYRFDIDDLKHDIDAKIREQEELRRQKAMEAKLKEDRQKELLEIKKREIERRKLMIPKPSNNKNHADDAINVKEEIKPIAKETKEIEKTAIRKKEIPQGTEGPKVTLKKEIHHKPKPKKPRKEKQLSMKMFMSDSDADESDLATQSESDDDVILSHKPTRSGRVPKLTQRYEDEVSLNSLIKEKENSRIPKRAELKNVEPGSVMIITEDGPNGEPIYKIFMVTPEQQATPLNIPSDDVAKVIQLRKGFTAHNIMTISANATTDEEDENSVENNFTIPEDENVTTLKSCDENSVDMVSEQNVTIPADASVTTLRSRVDNDTVENVIPEQNVTIAADASVTTLKSRVDNDTVENVILEQNVTIPEDASVTNLRSRVDSDTVENDLTYDISSPQGPLHDDDLQANVGNGDINAYSENIKIIATEPIILDNPTASTVSDSVCFIGDEKSENLNESNIQISVANTEERTEKFKVLATESSVLDDSGIQENFIVLDTQQSDLPINTEIVFRVNNDGMCSKELNEDDEQPLHQAPLNNVEMSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F913</accession>
    <name>A0A6P7F913_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Golgi reassembly-stacking protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114326962</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GORASP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131252.1">
        <property type="nucleotide sequence ID" value="XM_028275451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F913"/>
    <dbReference type="FunCoup" id="A0A6P7F913">
        <property type="interactions" value="1668"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275451.2">
        <property type="protein sequence ID" value="XP_028131252.1"/>
        <property type="gene ID" value="LOC114326962"/>
    </dbReference>
    <dbReference type="GeneID" id="114326962"/>
    <dbReference type="KEGG" id="dvv:114326962"/>
    <dbReference type="CTD" id="40177"/>
    <dbReference type="InParanoid" id="A0A6P7F913"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000056">
        <property type="entry name" value="Golgi reassembly-stacking protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
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        <property type="entry name" value="GRASP_PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
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        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="10">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131252.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46319" checksum="E063F641D1728C0A" modified="2020-12-02" version="1">MGNSESVDVPGGGTDGYHVLKVQENSPASLAGLQPFFDFIISINGTRLDRENDTLRTILKNGVGKQLPLTIYSYKTQSVRTVTVVPSDTWGGQGYLGVSIKFCSFDVAKEIVWHILEVHPNSPASLANLRPFSDYIIGADSILHESEDLYNLIENHDGVPLKFYVYNSDDDTCRDVTITPNSKWGGDGMLGCGIGYGYLHRIPVRGSAIQPPPTTTIFNQVPTISPSNDQSVSPATTQPITTLIQKTENLNLEPTGQAVQETNVSNVLSTAASTVQQDPSVYTSNVPAPSSIPNFNMNFQNPPATSDIPSFDVNKFSNPQNPVTSEAMVHPQVSLQSPQPIITPTMYNPADYPAFSPSQPPLTQTTVPVYSYPQMQSSGAPTNVLHTTTNSSLPPPPLSGFLNQPIIFDPHIAAQSAQQLLSGTVTTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB52</accession>
    <name>A0A6P7FB52_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114326489</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114326489</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="EnsemblMetazoa" id="XM_028274884.2">
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        <property type="gene ID" value="LOC114326489"/>
    </dbReference>
    <dbReference type="GeneID" id="114326489"/>
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    <dbReference type="OrthoDB" id="6696455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028130685.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15686" checksum="D611B2B92C6A8548" modified="2020-12-02" version="1">MRKFGMINPRHHPGDEEVALSFKRPCVCTTENVDIEKSFVYVEGTKTDNNISANLPELTENVWYEIRPQKLFSKQPIPLVTSRQTYITRVLLDGKLTHLEADEEDVEEEKSTIKNVSINIKKSAARFLGRAGVDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FC51</accession>
    <name>A0A6P7FC51_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">45 kDa calcium-binding protein isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">LOC114327880</name>
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    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF98">
        <property type="entry name" value="45 KDA CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028132397.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41505" checksum="33F4AE7DD18D82AE" modified="2020-12-02" version="1">MNVAQKIKYLECLRWSYTVPILCYLAFFVMIWMLAVPLKHNIKIVKDLKVNVEDSFEIRIKNSNFNTDKRGEEELIDKNEYLVDFNKDGTRTLLEVFEKADKDKNNKLDSRELAMWIRQKIVEHISTAISSNLELFSLIDISPQNGVITWREYHTYFLKKRGFSDKFIGDHDEKRHRGLERSLKGTYLSERIMRDKAAWTEAAKSNPNTLTIDEFLSFTHPESSVTNQLMLVDELFDKFDRDGDELLTEDEFAVLQTEGNGDEPLIVRQDENERREEFRKRIDLNGDGRADRRELLHYVAPQSPRHSEHEAEALLALADNDHDQMLSLDEMLAHPDLFLKSKMVDTARSFHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG25</accession>
    <name>A0A6P7FG25_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SOSS complex subunit B homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329049</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133862.1">
        <property type="nucleotide sequence ID" value="XM_028278061.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P7FG25">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278061.2">
        <property type="protein sequence ID" value="XP_028133862.1"/>
        <property type="gene ID" value="LOC114329049"/>
    </dbReference>
    <dbReference type="GeneID" id="114329049"/>
    <dbReference type="KEGG" id="dvv:114329049"/>
    <dbReference type="InParanoid" id="A0A6P7FG25"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028133862.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23328" checksum="3D384E906B4521B4" modified="2020-12-02" version="1">MDNYIQIKDMRPGLKNVNVVFIVLEVGHPTVTKENREVRTFKVADQSACINASIWDEAGHLLVPGDIVRLTKGYVSVWRNCLTLYTSKGGDLQKIGEFCMVFNEQHNMSEPNQIQPQLPPGPTNSMNSMPMNNGTNNATGRVNVGPPQPPPVTTTGPPIVPPMQHNNVAGPAKPTVNSTSTSRSSGNGPPPADNQKRQRGQRTTQHRTRTNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH52</accession>
    <name>A0A6P7FH52_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Krueppel-like factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114327944</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028132468.1">
        <property type="nucleotide sequence ID" value="XM_028276667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH52"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276667.2">
        <property type="protein sequence ID" value="XP_028132468.1"/>
        <property type="gene ID" value="LOC114327944"/>
    </dbReference>
    <dbReference type="GeneID" id="114327944"/>
    <dbReference type="KEGG" id="dvv:114327944"/>
    <dbReference type="InParanoid" id="A0A6P7FH52"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF166">
        <property type="entry name" value="DENDRITIC ARBOR REDUCTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028132468.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42518" checksum="F440707EB39A2482" modified="2020-12-02" version="1">MTDFYMVLEPSMFLTSDLDTFLCKQDWERPLDEELEKPRRDSVPQIDDFFEASHHNNNNNTPNNNTRHQAMSYVSMRSLPGADDDAFLRPPALWEDIASSIQNIDPENANMLGVSPGHVKLEAVDDLTVSCGATAPSPLLSPLEIKTEKVLQQSCPTLHLLGTPTSPYTQPQPTSPQHHPPHYHPQQAMHHPHNNNNNQYKYNNVAGAQAGPAPGNALYPMPSRLMYVSPLTPPSSEPGSPGGALPRRTPPPPYPAPGCPQQTPAAAVPRISGVKYNRRNNPELEKRRIHHCDFIGCTKVYTKSSHLKAHQRIHTGEKPYQCQWPECEWRFARSDELTRHYRKHTGAKPFKCGVCERSFARSDHLALHMKRHLPKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHB5</accession>
    <name>A0A6P7FHB5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114330335</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028135459.1">
        <property type="nucleotide sequence ID" value="XM_028279658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHB5"/>
    <dbReference type="FunCoup" id="A0A6P7FHB5">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279658.2">
        <property type="protein sequence ID" value="XP_028135459.1"/>
        <property type="gene ID" value="LOC114330337"/>
    </dbReference>
    <dbReference type="KEGG" id="dvv:114330337"/>
    <dbReference type="InParanoid" id="A0A6P7FHB5"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="15"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028135459.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="32951" checksum="4915ECA91CD79ED3" modified="2020-12-02" version="1">MAPVIEKLVEGFKVAEGPHWDNKKQCLYFVDITESTICKYVPSTKKFTKAKIGDYNVSLIIPVKDKNNEFVVTLNNSVAVVEWDGESPNVSSVKNLYEVEAGTNSAINDGKCDKMGRLWAGTIGGSPKTIDEIKPGIGTLYSFSNNTTTPHLTKVGISNGMAFDHKRGKMYYIDSLSFKVDQYDFDIIEGKISNMKTIFTITNQEYLCDGMTLDADGNIWLAVFGSSKVYQIDASKPETVLRVVELPAAQITSVAFGGLNLDELYVTSAHFTDRPTGESPGSVFRVTGLNVKGVPADEADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIJ9</accession>
    <name>A0A6P7FIJ9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase LRSAM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114330708</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135924.1">
        <property type="nucleotide sequence ID" value="XM_028280123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500018.1">
        <property type="nucleotide sequence ID" value="XM_050644061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIJ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644061.1">
        <property type="protein sequence ID" value="XP_050500018.1"/>
        <property type="gene ID" value="LOC114330708"/>
    </dbReference>
    <dbReference type="GeneID" id="114330708"/>
    <dbReference type="KEGG" id="dvv:114330708"/>
    <dbReference type="InParanoid" id="A0A6P7FIJ9"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="639"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028135924.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="78348" checksum="78BBE627795D7E2F" modified="2020-12-02" version="1">MFRRKQPNKAKLEHKLYLARENPEPVFDLSECDIHNVPSGIYSLCRVFLKESLRLENNSLSSLSGGGSLKDLYVLKILNLNNNLFSHLPDDIGLLTNLEELYVSNNHLKKLCGGVCTLKKLRVLDLSNNQLKALPEDLGNLGSLRKFNITSNKLKHLPKSIYKWRKIQTLDIDADEYVYPPSSITTQGLTSIMKFISVDVGVSFSPEEDEVDAEEDKYSPIEDSTDSVQEKIWELANIKQQKMKEFLEIEKLNEVMMRQELEYANTSKLNRDKLLAVLVQQQDIFDHELSKIHQEKEFERFRLIEQLQEVEQNADLAIQEMLLNNEPLSQLLEQEKLEEEKLLSAINRYNETLRKDDILAAMQDILAQETAKFKEFHESRLETSKSILEQETEIDSKLIEVLQNQDDHKVELINKLIIDNDLQKAAVGTLLERGDARSWGLLQQIRLVEAQLAALTRIEIDRKKLEMDEHLNDLCVKRCNLSMLLIDLLEQQKERRAQLISTLQVMEESHSESIEDFWLRQYQRLLDKLPEGLSHAQKNIDPSLAQALLLNGVIHCLPFLAKLTQSQCDTRYITEDDLLTAGVTCGDERRKILDAFEMYERGKKVLGCDDTCASAPPQPVEEASAPIPENIKAISSSECVICLDLECQIIFVPCGHLCCCCDCSVPISDCPLCRVTIDRKITLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIW1</accession>
    <name>A0A6P7FIW1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein caupolican</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114330659</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135866.1">
        <property type="nucleotide sequence ID" value="XM_028280065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIW1"/>
    <dbReference type="FunCoup" id="A0A6P7FIW1">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280065.2">
        <property type="protein sequence ID" value="XP_028135866.1"/>
        <property type="gene ID" value="LOC114330659"/>
    </dbReference>
    <dbReference type="GeneID" id="114330659"/>
    <dbReference type="KEGG" id="dvv:114330659"/>
    <dbReference type="CTD" id="39441"/>
    <dbReference type="InParanoid" id="A0A6P7FIW1"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045317">
        <property type="term" value="P:equator specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007474">
        <property type="term" value="P:imaginal disc-derived wing vein specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042693">
        <property type="term" value="P:muscle cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00548">
        <property type="entry name" value="IRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028135866.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="51716" checksum="D0C95B805AE4BD3B" modified="2020-12-02" version="1">MSQFGFRASPNTQSAVSSGPSQSSSPPTTMAVTSSAPTSGSPPTPSQRCCDTGRPLFTDPITGQSVCSCQYELLGYQRLAGAGVPGLPALSMYSAPYPEGMAAYFPALGADQAPFYTPTAAGLELKENLATGAAGWPYPSVYHPYDTAFAGYPFNGYGMDLNGARRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNRVEDDDNNNDDDDHDHKSTDGKDIIDSKDSGTASSEDGDRPPHSRLAADTASEWSESRPDSGPDSPEIYERPPHPAFLPPRSSGSPPQLSASVSTKPRIWSLADMASKESDGPPHSAASTLYSTASGRLVPPLGTRLPPPGLHTAPYARPHDFYRSLYNPAAAQHLAAASGGSPDATLLETYQRTLGANLLAAQNASASVAQSTPSIFTKASVAAATSSASSLPLGLTTASRMSPSSTSSLSSGSETPIKPVALNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJM1</accession>
    <name>A0A6P7FJM1_DIAVI</name>
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        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Galerucinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135207.1">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="LOC114330090"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBFA_NFYB_domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
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    </dbReference>
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        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
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    </dbReference>
    <dbReference type="Pfam" id="PF00808">
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    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028135207.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13904" checksum="2941E4C313C975C7" modified="2020-12-02" version="1">MDAEDNEPNSKPDELNVEVEEHGTEDENKEDADLKKSGQRNRILRLPLARIKNMMKLDPDCTIISQDSLFLITKATEMFIEFMAEEASKQLSHGKRKTVLKRDVDIVIENNPSLCFLDGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A6P7FJN7_DIAVI</name>
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        </submittedName>
    </protein>
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        <name evidence="8" type="primary">LOC114330936</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
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            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47487">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47487:SF8">
        <property type="entry name" value="OS08G0270900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028370166" evidence="3">
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            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
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            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
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            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="37"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028136186.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19963" checksum="0283C03296B10EDE" modified="2020-12-02" version="1">MAKFLHTLLYIVYSVTVEMSGDIHNRGEIHNRVEDLPKNFSKQKSDSEGENTDKENGVDDLKKQLIQPLSCEICRVKVTSTKIFQRHLDGRKHKLRAERQGKEFKCELCDIIANSEIQLEIHFRSFRHKSKLQRKEHPHFSLLTSYTSKSSFLVFLCFTCIFLNLFLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQN9</accession>
    <name>A0A6P7FQN9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 13B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114333037</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="interactions" value="905"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655825.1">
        <property type="protein sequence ID" value="XP_050511782.1"/>
        <property type="gene ID" value="LOC114333037"/>
    </dbReference>
    <dbReference type="GeneID" id="114333037"/>
    <dbReference type="KEGG" id="dvv:114333037"/>
    <dbReference type="CTD" id="157680"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3144"/>
            <end position="3182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3153"/>
            <end position="3163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12624"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028138659.1"/>
        </source>
    </evidence>
    <sequence length="3840" mass="433259" checksum="1DB939BDC2B01FE2" modified="2020-12-02" version="1">MFKIESYITPILLSYVNRYINNFKLEDSQVSLWGGDVSFNNLELNLQVLEQELQLPFSFVSGSIRELLIHVPWTKLASEPITITINTIECILNLKGKETRGRADPTASGREKKTGHGKEMEAPQGYVQLLINKIVSNIRIYCNNLILKYVEEDIVLSMNVKHLKFESANDKWEPSYIDVSPAEVILRKVITINDLTLCLDKRNASGKIEVYQEPMLYKCSMTMHLLKKYHSATASIASTTRLDIYCNSMEFSMTEQQVPMFMRLLLLLYALQQKQLKPERDSTTDASVSSQDGRDIQDSSLGWTGWAWSYVSSVLPAPWDEDWDEKYLQDHKGHTLHFGIFVDNLSITFKVSETTSERTSYYNHKKLRYTPMLSLQLQGMYCETVIHGLKWFNAMGGVSQAILLPMGPCSCSLIEIPDEASQINYLKIGSETNTHKSDSLFDVEAVENKGKKRQYNTSWDYHMSMYTESVLLERTPAFAFDYLYQMDMPNDTSSEILSEMGSDFEFSNFVENSSMRLCLGPFKLRLCSGFFHRLSSLQVAASYYDYPPYAVPKPDKSFQELQPPSEEDFDALNEFIPSRSMRITFFAPIIELELMDHPYFQPIKGMLYRKRKKGTQSTPSTSKVLPLPKLTIECQFFDISLTYPMYVNRLVHTTCQLPDPPRQFFEACYSRKNIKVVGLCSRLIINPNKHTTILTPSSLSYTTKSINKPQYWTNPDITHSEATFESESITLNGTNAKMMVVTYIVGKMLKMDAEGAIKLMNNSSILIDASKDQGLPFMELCIEAIRFKKVNTNSTVSMDVSLGSIKGFILEPIHKKVDDSSFSNDIQQVLFISGPEPKSTPEGEEVVQKGPSGEPSYAPLFTATIQYPIGPENQQHPPIILFNLQEIRVCIDPLLCKWLLYTPKQFGHTLNMYECGPKTKNVSDVSSSVAETPRKVSSQIESVHSSSDREHLYIPQKVQVTREETVDIQEKIYNFLKKWFDVWKGVFLCGDISQCTIYFPLGSLSAIGSQGIQEAVESAVNKEQPPDILIITLPLANIRSAHRQSIKKYLNTLPVTLPDTIWTSEKSSFPWTMSISDMSCYTIQFGKKLTFLKPVSLNATVGLSTKPNKPEGEVNLDTSKPDIGCIGVCVHIDMTPIVISTSEVQVYLFASILYGLMEVASNLMPETAPNVVPKTPDALPPVLSKSSTMSPTILKENTLDSTSDRTPPIATLSQQETTDETARLTAWVQWTITRFTIELLSSECKDTLSDNLAPPQPRLKLVVDAEDIVSSLDFQSVYLKLKSKIGSVSIQHYKRFTPTSDWQPGPFSGIVMRLREDVAATQRHEDNGFISITITRASCQHTHTLWGAVQKRHHKEPKRGESLNPQLLSQSRYITEIVVNIQPIDFVISPKTLRSFYMVIVPLLEIPAHKETKVSDTSVSLLDINNQNLPLAYLECQDIRIIIPSAELGCKHTLHDVILFQVQKICISPSAVNPICRSPLRPDIYEQAAHARILSIPGSDVEDRQYQLDLIGMSLCTGAWEDIDSVLSPSNFTSTLKGLSENPALEWNNLEQGQSNFPHPSLNLWYLTEKFDISLILAPAMIYKETTLVCGHSIEINFVTDIIINLSLQQIKLISALLHEFEASMEPLIVDKQFVKMKLHLPYTRSYDESLYEEEIESNDVCRDSGIDTLDNKSILSSSRILKTLSESEKYTPPKPSNILNSNQLVPFDILVTAGKISLALYQVILPTTGSLRAKNKRKKSLKIDINASGYEAEEEGKTENENNYNKYTPLAYLCISQPNIFMNKKQLTRGVQITCFDLNLKLSGPEYLPVNHIPTEDDFPVNLLETKCGIPDYNTEIYPAFFTAKFSKGLGKNAALNISIAKPTKILCSTTKWGYLLTVKDQVLDALGNKCEMIPVPRSIEKSSEPTNIIASIPWGINVVNVDFKQLLFSIKSDAGYEIHLGMEKLSTNLTLSTRPDKITVKTNLHCVTISIINGLYKKLLLNPWSTSVDVSMFWESWQSQNSDPQIQVSVESDCIMLDISPEQIRCIEIVAKEVNEFIATLPITESGSAPESVNVENTSGKGFDKDQHYKDDLRAGAFQFVDANSDKTEELPLPYQVMFWNKSISAMAWRYPQPRALTKVRVFPVPYKRTLGSHDDLQVLCHLEYWAECRNAYLPFAQFFLSESEVCHLTLPAGNPQPIVASTWRVVITMVNYNEEQKSSILISPRALAACMRIDSYFNKSLIPSLTAAMYITRIDVSLYNYFDRYNTMKLPTWLNNFSPDYMFPENQRFLTLSWYNMTGYFLNWDRDTMSLELSTAVKCNVLDYNFLTEQPLIEPFTCKMEATVSQDVSLNLISKPIQVKFGPNIAHSLAVAVQVWDQTYTSPDKEKDFIVMTRIIVCNDTISSIRFGQASTDEDILLTSRQFHLYSWRSQKKKQKLRIALEENDWVWSRSFPLIQDGMEVIQFSTERNISIFVSIQSLSATQKKITVFGQLIVSNMLLEHFEMKVVESVKEKRDIEFKNSTTILIPSHNNTPSIFINNKKKYFLRLRFYGLESAWTGDIPLKEHHTGSQPWLVKVPLQERGQFLSIWCRIITQEINNTKRILAVLWPLFTVKSNLPVDSQVHIETPTLNVHIDSTVCGRGQIQQLYCPGTIDHPHQLTFKIDNNEATSNSYIPLNYSNVDQHKFFKRPEREDIEEILTVLSNFNKKSWPYFGDELDEIDWVVDDQPLTHVQVKYQKACPHSCSLLLELLPWCLTVNTLGIPISLMLSGVELCKIPHHGIVAPPKLEENFNLGVYMGNSWYYSEPLQLSKSDWSQAFYMPKITGSIPQNGCIKTSIKCDSHICSISIASSVTNEMRLLKVSSTHVLSNHTATQLQVICLAVPEGENIYDFPDNAEPYSFTLAPYLNKSNSGVSVIKWHTPINISGFSEYALYFSFCLSADVGWSCPIRVDKPFLRKAFCVTSASHPLAFVLTCQEHKGQLFLSLHNDTRPQVLISNRTGTTFYCGQSLKEGEVVDEVQNFRWYCKIGPHQEQYYNMPNISEKFPELPQYQFSEKIALAIEPDINNDFQWSTNFSLTHEYEQYLRIPFYGDIQIIVVNTACTTFLILESASEMEISASDIRVRLSLRESEGVGEKHSETLQLPKLYSREEVPRFISDTAIQSGARRRSSIKTRQNSTCSDNGSSEEYSKSRRRSSGSNLGLLSPKTKSLLVNTLPMKEIWNCMKLNAFIKSFSVIFISDLKIEGTERWEVASLSCDNIVVCATQTEKMKVKFSVSAVQFDNQLYSRESYDFPVLLVGQDVKESNKMPTLNIPIENLLQNSDEEALLVVDLALETWRDKYVMSNTTGVKSLQIVINPISCFVEDGYLTRLMDYFYVFIPTKLIMWPDKKLPLKLNGTSGSVSVPEIVSWQCAILARPLTVRNLNIAPISLLLSIHSSIKMYIALDQSPLQFGKFERKRVFTTPYRLGHAMTMHYLSGAIFGAGWVVSSLELIGSPGGLARAMGTGLRDFVSLPYRGLVVGPMAFLRGITQGSASLMRHITAGTLQSVTKMASSVARNLDRLTLDEEHVRRKEEERRMRPQGLAQGFLQGLTGLGISLLGAIGGVSHHPLQSIMSDGASPRSLVTGVGLGLVGMVTKPLSGAAELVALTGQGLLQGAGWTSLPEPRNSPSIDKINQNANSLLKYSWKNIQALTPSHLLYVTEATSISNTQYEAIALILTLESLIVVNLETDSTQRVINLSDLTVCPSSDPTLLIFKLNPPLKTPTMEEESVEMDPVSRARVAEYVKNTVGVLHLPEASDLPDQLNFDVSPLSSPGPSSEVDVSVESTVLTYYVNLQSRNYFLCLLNLAKQQRQNYNFTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FR29</accession>
    <name>A0A6P7FR29_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trypsin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114331779</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137232.1">
        <property type="nucleotide sequence ID" value="XM_028281431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FR29"/>
    <dbReference type="FunCoup" id="A0A6P7FR29">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281431.2">
        <property type="protein sequence ID" value="XP_028137232.1"/>
        <property type="gene ID" value="LOC114331779"/>
    </dbReference>
    <dbReference type="GeneID" id="114331779"/>
    <dbReference type="KEGG" id="dvv:114331779"/>
    <dbReference type="InParanoid" id="A0A6P7FR29"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027960890" evidence="6">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="163"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028137232.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44688" checksum="7FE3142BCE62AC38" modified="2020-12-02" version="1">MNFYIVALFCGFSWVVCGGSLPREHYPEETLFNQNLYKKFRPVSTTDSSASLTIKKPYKAFNTIEKPFHIYRNTIIRGPPKDVDDAISNLVTENVVESKPLVIRKNASNPQHHFIKQPEKANVVDWFLGLVGIRQPDPNAAPVEPTKICPSCTCGKTFKNVRIVGGIETMVNEYPWMTALLYNNRFYCGASLINNKYCLTAAHCVNGFTKEKITAVFLDHDRSSSFETNTISRKVMNIFRHRGYSTGGTYNNDIALIELDQEVPLTGMLRPVCLPPTGKSFTGLQGIATGWGATKQNGQTSNKLREVKVPIMSNIDCRKTGYGNKITDNMLCAGYQGGLKDSCQGDSGGPLHTKNGSFHQIVGVVSWGEGCAKPNYPGVYTRVNRYISWIKSNTKDACYCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FU30</accession>
    <name>A0A6P7FU30_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">(11Z)-hexadec-11-enoyl-CoA conjugase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114332689</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138317.1">
        <property type="nucleotide sequence ID" value="XM_028282516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FU30"/>
    <dbReference type="FunCoup" id="A0A6P7FU30">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282516.1">
        <property type="protein sequence ID" value="XP_028138317.1"/>
        <property type="gene ID" value="LOC114332689"/>
    </dbReference>
    <dbReference type="GeneID" id="114332689"/>
    <dbReference type="KEGG" id="dvv:114332689"/>
    <dbReference type="InParanoid" id="A0A6P7FU30"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF98">
        <property type="entry name" value="RE43130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="86"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028138317.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="45461" checksum="712F861884E7D840" modified="2020-12-02" version="1">MGNEENMAPHLLSNTNLLLAEVNETQKTHLSSKETYQPTQTTQAKPAKKEKSDGSEIVWLNVMVFILLHSAALYGLWLMLSLQTSWKTFVFSAIYLSFASTGVTGGAHRLWAHRAYKAKLPFRIWLMLGQTAALQNDIYEWVRDHRVHHKFTDTNADPHNSTRGFFFCHVGWLMMKKHEDVKVKGKTIDMSDVAADPVVRWQRKYYIPLVTLLTFLLPTYVPYYFWKEDFMMSFFVCIFRFVLQLNGTWCVNSAAHLWGYKPYDGSINPVENRFVSAIGFGEGWHNYHHTFPWDYKAAELGNYKMNYTTALLDFMAHIGQAYDLKTVSAEMIRKRAHRTGDGTWKDGKIDINAGVEKNLDKNQFYDDCVWGWDDKDMTEDVRKDANIKNKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVL4</accession>
    <name>A0A6P7FVL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114334652</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140544.1">
        <property type="nucleotide sequence ID" value="XM_028284743.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512050.1">
        <property type="nucleotide sequence ID" value="XM_050656093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVL4"/>
    <dbReference type="FunCoup" id="A0A6P7FVL4">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284743.2">
        <property type="protein sequence ID" value="XP_028140544.1"/>
        <property type="gene ID" value="LOC114334652"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656093.1">
        <property type="protein sequence ID" value="XP_050512050.1"/>
        <property type="gene ID" value="LOC114334652"/>
    </dbReference>
    <dbReference type="GeneID" id="114334652"/>
    <dbReference type="KEGG" id="dvv:114334652"/>
    <dbReference type="InParanoid" id="A0A6P7FVL4"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028140544.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="69234" checksum="5515BF11C11B0201" modified="2020-12-02" version="1">MLKMLRSRLYEYPSHQSHLLEGLNSLRTRGELLDVTLVIEGCAFRAHKAVLAACSDYFRAMFTDNMLEATQTEICLNGITAKGFDHILKYAYTTQLALNLANVQDVLEAASHVQMVAVVQACSTYLQNQIDIDNCVDIATIAETYSLSTLSKIVYGYMSEHLLEFSNSSEFYRLTPQQLENLLAFDYPVDCSEADVLRIVLTWFFHVDTNELAIRLTYALRIIRYIHFVEISQRKLESILDKVFEDRKCEWQLYKIIIQEVYRQTTNEESRFISSLLNSRGMEMAVLKIGGFGMSGITNEITYSFASERQWKHLTSIPHVEQCNFGTAVFNNELYIVGGCFNQSLQENIHPFGFKYTPRYNSWSTIAPMKIERCRFSLNFVGEILYAVGGASEADELDVSTCECYNPLLDSWYMIPHLPIYVTQHAGASYENSYDMKLFISGGIDRDNVQSNQMYCYDVNLEKWQMCSPMLKPRADHVMLTVGNYLYVCGGWTEDSETRSRTLVGTIDAYDVERDIWKVITTVPTPRYHAGIVCVEKKIYFVGGFSSDDAFDRDTAAIENYDLDTGQWTVEDKYPQDIWEHTCASLYIPKCREDMEVLAGAEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW13</accession>
    <name>A0A6P7FW13_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114334815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140714.1">
        <property type="nucleotide sequence ID" value="XM_028284913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW13"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284913.2">
        <property type="protein sequence ID" value="XP_028140714.1"/>
        <property type="gene ID" value="LOC114334815"/>
    </dbReference>
    <dbReference type="GeneID" id="114334815"/>
    <dbReference type="KEGG" id="dvv:114334815"/>
    <dbReference type="InParanoid" id="A0A6P7FW13"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027907193" evidence="1">
        <location>
            <begin position="22"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140714.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17325" checksum="214F7248F29977C0" modified="2020-12-02" version="1">MRPVILILAMLSILTISKISAEEDRKRPDWCPEMPSTTREDVDFFVNRTLPFLYTWTGLMDPNECPEDHIGLATAIRLALIKYNEEQYGPPRVVQMRLGSSNTRYSNFYHFLEFLGPIILTQIPNLTIRKCIPHDYPISHQIMHVHPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWA1</accession>
    <name>A0A6P7FWA1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tuberin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114331759</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137198.1">
        <property type="nucleotide sequence ID" value="XM_028281397.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FWA1">
        <property type="interactions" value="1103"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281397.2">
        <property type="protein sequence ID" value="XP_028137198.1"/>
        <property type="gene ID" value="LOC114331759"/>
    </dbReference>
    <dbReference type="GeneID" id="114331759"/>
    <dbReference type="KEGG" id="dvv:114331759"/>
    <dbReference type="CTD" id="109822"/>
    <dbReference type="InParanoid" id="A0A6P7FWA1"/>
    <dbReference type="OrthoDB" id="5797019at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1781"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1790"/>
            <end position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028137198.1"/>
        </source>
    </evidence>
    <sequence length="1813" mass="205426" checksum="F7E9DA361E0B2C65" modified="2020-12-02" version="1">MPQNMGSKDKSIGETLKNIFKRNKGALGSLGSRSEVLVINDELLKDLGKDSPLNTRLRILKEYSTRVAENKLENTAVEKLWKAIEDLFSPEYSTEVRHLAFHFLQCLLRGQLNLNDLNEIMRAIFFHFITQHSHPDDIIQRFDLLNILTQNGITLLHFEEKVGRFLLNWLPDISQAGKIEEYLTMLDNLVRYNAAYLDDEVISGFIQHICVLCCSSSSKTVQSCLQIMSSIVAYSNMPPESLPKFIGALCRTVNVEEYCMLSWTVMKKLLGTHMGHSALYTMCRILQEPALSSDADLLRGAVFYTHMALWSSAPLSNLHCPPSSVLPSFLQAVKCNHAAVAYEVILGLKCLVNKQGPELQDPAWSILLEIISHILCHIDLTSSQSPNRLIVTPLHDTLNFIEHLMKVDSYNGSVKQFYGIIEECSADRPESSILGLIVHHAQSIVPTEHLWLTNLYNLLQKYFKLEIRKNIRLKVLETLSHVIKLNRRQYEDELIDRIVVPHMANINYNTDIVVRSSVANLLIDLCLECESKKCLDLLDILEKMLLRPFDTYLSDNSSHSDAEFADIKCLVEGLIKVFIVKIHKLPSTHAIKIYKMLVKFLELHYNKPRLFENCPIVRKMIFECFLKIRADNLYHIGYQDGKDLKFSSYICVVYKSTDRGNLGSPVPQSPAPIQRLPVTVTPVSLKAAFKIFITCLKTEKDWEVLSLVITEMTKILQNKSLILSKNGNTELDLLVDVLTSMITEKIYNLPESLNVLVSRADFHATVLLAVVNLVSYHSVLDQIHQQKLLRCLIKCSNSIGPRSSKHCIAALTLCCLEMRETMVKCLPEVLLNLSKISATVHIGIPILEFLSTLTQLPLVYTNFVADQYMSVFAICLPYTNPFKYDQYTVALAHHVIAVWFLKCRLSYRKDFVKFIIKGLQTNILHPFEETKSSIFNQNLSELNQDSSDRKRSSSLTEQGSRKRSATVSSVRDKPVVHKGPDKFYFYEELTETCTDLMARYAYSPCSALPQRLPVAEFLMNGGQSMCWLLGNKIITITTSGCSKKILKNGLCDKCWSLCSLQNDSRKTKTGRSGSNEMEDLDWISRQNSNDKSNTNTSVSSPAEDKKNIGDKLEIVSSKLQQIASSYRQEKETCNCWCSGWAEIYIRRPTGDNSWVMRIQNTMSFTNAIYDFPLNEVSTLFRPSLHFEDANPHRRPPLTRQFSEEQKEEEEKNSANSGSNPSLTGSPKHTPSRQNSHDSVDEELDSIYDDGNRSRNPVRRSNSSPEMSASWKNPFLHQKMSSDEDLKNSDDEGGKKNKGYTKDMRVSCEAIPEEIAGSGTTPPSNEPVALPKADQSQTGYTTSLHPSLLSCHSYPGSSPPKENIPPKPYQTVPPTPNVTSFSNQPPEFMKRPTNLPNLGNLVPLSSKPPQSPTQTSPRFGRHAYGIAKDKDGRDLQKSSSASTIEKNTTLNLNWARERARERKNSGSVERLTTLDPNLAQKRDRVFTISTSQPSTRKSRSEMAQAAQQKKKQDDAPKSGINPSFVFLQFWHTAKFGSKSERPVMLKVTEVVNRAFKVLDAIPPYETHKIGVLYVREGQINSEVEIYKNRFGSLRYVQFLQQLGTLVKLSDVDPQTFFLGGLDQHGNDGKFAYIWQDDVTRVMFHVATMMPNKESDPTCNNKKMHIGNNFVTIIYNESGEDVNISTFKGQFTFACIIIQPLDMGINRVTVKVKEELANLIASSEPKLVSDQNVGIFARQIALHTNMASIVTNSLKHPNERSASNWMGRLRQIKKIRNRAIQDQKNNESIYQNEERKEKTNEESKNKYMEDFTHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZT4</accession>
    <name>A0A6P7FZT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114334462</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028140302.1">
        <property type="nucleotide sequence ID" value="XM_028284501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZT4"/>
    <dbReference type="FunCoup" id="A0A6P7FZT4">
        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284501.2">
        <property type="protein sequence ID" value="XP_028140302.1"/>
        <property type="gene ID" value="LOC114334462"/>
    </dbReference>
    <dbReference type="GeneID" id="114334462"/>
    <dbReference type="KEGG" id="dvv:114334462"/>
    <dbReference type="InParanoid" id="A0A6P7FZT4"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="45"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028140302.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37445" checksum="1DE0D03B1E7AA564" modified="2020-12-02" version="1">MSSLMATQAEKVTIEITLDKANGDTKCNGVQSKVSEQNKKHEEYQYLDHIHHIITNGNKRVDRTGVGTYSIFGAQMRYNLRDSFPLLTTKRVFWRGVVEELLWFIKGSTNAFELSDKNVHIWDANSTREFLDSIGLKDREAGDLGPIYGFQWRHFGADYKGMHESYKNQGIDQLAHVINTIKERPNDRRIIMCAWNPIDIPEMALPPCHCLVQFFVANDELSCQLYQRSADMGLGVPFNIASYALLTYMIAHITDLKPGDFVHTLGDSHVYLNHVEVLKEQLKREPRPFPKLTIKRKVENIEDFTADDFEIKGYNPHPKLNMPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G144</accession>
    <name>A0A6P7G144_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein obstructor-E-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114333160</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138793.1">
        <property type="nucleotide sequence ID" value="XM_028282992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G144"/>
    <dbReference type="FunCoup" id="A0A6P7G144">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282992.2">
        <property type="protein sequence ID" value="XP_028138793.1"/>
        <property type="gene ID" value="LOC114333160"/>
    </dbReference>
    <dbReference type="GeneID" id="114333160"/>
    <dbReference type="KEGG" id="dvv:114333160"/>
    <dbReference type="InParanoid" id="A0A6P7G144"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000002">
        <property type="entry name" value="Gasp, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF104">
        <property type="entry name" value="BCDNA.GH02976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027901988" evidence="7">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028138793.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32627" checksum="478F315C928BFFD9" modified="2020-12-02" version="1">MSANSSTWTFVFIAILALGVSGARNRNKRPQQEPVEVDDSAEISDQCPEPDGYFADAEQCDKYYHCSNGRITEKLCPDGQVFNDYSSEYEKCDLPFNIDCSSRPKLQEPQPSEHCPRKHGYFAHDQKNICDKFYFCVDGKFNAITCPNGLVYNVKAGICSWPDEAKRSGCTSEEVFEFQCPKVTEDVAITHPRYPDPEDCQYFYVCINGNSPRRNGCKLGQVFDDVTKRCDWARNVPECADWYQGRLTEQQLKDLENPPTARPKATKGSKRKGQRPRERTVVHDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G207</accession>
    <name>A0A6P7G207_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC114333413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114333413</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139082.1">
        <property type="nucleotide sequence ID" value="XM_028283281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028139083.1">
        <property type="nucleotide sequence ID" value="XM_028283282.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283281.2">
        <property type="protein sequence ID" value="XP_028139082.1"/>
        <property type="gene ID" value="LOC114333413"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283282.2">
        <property type="protein sequence ID" value="XP_028139083.1"/>
        <property type="gene ID" value="LOC114333413"/>
    </dbReference>
    <dbReference type="GeneID" id="114333413"/>
    <dbReference type="KEGG" id="dvv:114333413"/>
    <dbReference type="CTD" id="39583"/>
    <dbReference type="OrthoDB" id="42382at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="57"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028139082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028139083.1"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147972" checksum="42F0968EFCD5B492" modified="2020-12-02" version="1">MSQATVDNFVTVVSVGPRDKPESNENINFDSTGSGYVTVLTIGDDENQKDIKEVTEEVIVYRLPGERLGFGLKFEGGTKATEFVKRLFIQSCAADSPASRVKSSWDKLTEGDEILEIDSVAVNTMTRIDCVRCLKDSNVAIKLLVRHTYGQEIKKQETSPLIISAEEKRVPPPPPPVPPRKISRKLLKNLNNNVPKEQVDSAVGNNVANVRSTETSKQKKLQSPRGSVRSYSSPDVLRRDRRFSDGSLVPPDAEVYVDLFLQESTQSLSESDDTGSTISTVIDRFGSFPATTTSSFSGSLPSTPTSVQRQLDISNINIYEDDDVVHGKSLNKPIPLPREENNNIIMEEVNPLCFQDAPLSYGNESTKVIVPDEIDIIREEPIVLQENRQVSKKPPVPPRSRDTHLSSQKSEKCQENLPRLVDFVPKTANGVKEVENTTEIMKMFLENERYKQDFEFFDKEPDNDKYINGVDLYSSKWSLSSQLATIGEVEEEGSSDCNFNRSSPPKTTPVVIVENTEKRDDTNTPHSPETTKKEIYGTMETLPSDSRQPPDGHEFPEHDESQFKKVSINVNLINDRFLSAGREDSPKPTNRYFIQSTSTTDLRPKMYESTEDLKYSDFLPEPTPLYTRSQSLTDVSSLSKKNTKWNQMYEQRRKGLSKLKGLVIPEAAENDLSPSVNLPEIKSQTPTMYIPVPKLDNFSSSETISTSDADLLRTSIVIPSWSPSTPSNLPKYSPAFKRKSLQVYPTSKSDSDYSNNLDFPMKYCDKVSPKGSKVSDDDLNPPKSLESISSPTRSDCSFDYISSSKKYSKNNGDSFHKQSGRMEDESDNDSAVSSSQSSYNSRYSPPSSPTRSCELNHYSKKLEEDDRSAQNRLLKPSSVEAINRKNILASAKCRSGKDLKIGSPVIRRKQEEAQQESENHLLKSDEQEFALPGPVVLQKPPIPATTVDSIRAPKEISQEFVKTSETSSQKTTNEPVRLQREQLDKRNNGTTTKVASTNIFLALNSSSLNHVQTKLPEETRNGKSKDYLSTNSNSRKPGPINVKALKKNFENMNSSPPVSPQKVPFFKSAESRSNSKVNDIIEGKTTLPIRNGIGKSVEKLDVSLPPKSQEKKSSEVETKTITLKTDPFGTSLGITLAGGVDENKDITVHRIKYSSIAYIDGQLKKGDKILSINGKSTSDLTYLQAVELLKEPVTEFNIVIEEGENLVPSPVSSSSSLLQRRSSSMSSVLSRTKSPSLEVLEEKEANNVISLIKDGAGLGFSIEGGRDSPQGNVPLLVKKIFTGGAAEKAGKLNVGDEIIQINDIKFTLLTRIEAWNIMKKIPDGKVDIHIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2H0</accession>
    <name>A0A6P7G2H0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114333162</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="RefSeq" id="XP_028138795.1">
        <property type="nucleotide sequence ID" value="XM_028282994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2H0"/>
    <dbReference type="FunCoup" id="A0A6P7G2H0">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282994.2">
        <property type="protein sequence ID" value="XP_028138795.1"/>
        <property type="gene ID" value="LOC114333162"/>
    </dbReference>
    <dbReference type="GeneID" id="114333162"/>
    <dbReference type="KEGG" id="dvv:114333162"/>
    <dbReference type="InParanoid" id="A0A6P7G2H0"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="141"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028138795.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="79773" checksum="D8A17A222C17C5B5" modified="2020-12-02" version="1">MESNEDKCKDGTKSGEESSGTKKAKSDKWSNLDNMERCLLYIGGGAGALALTGVAAASAYYLAKGASPTPQRPLFPLEAQCIEEEEGPDLIRVSRFFNQAKEGKFISYVYSDAKTLYESFRRGSKVSNNGPSLGWRESYSKPYQWLSYNEALLRAKNFGSGLVASGLPPGQTTIIGIYSQNCPEWILTEQAVYCYSMVLVPLYDTLGPEACAFIVKQAEITTVVCDDDAKCNLLLERSPRCLKKLIVMRDVRAATRQRAKNRGVDIIKFTDLEELGAKTNHPEVPPKPSDLATICYTSGTTGNPKGVMLTHENIVASMSAVIMQFGDHKLRNNDILISFLPLAHMLERCCENAMYCVGGAVGFYLGDIRRLSDDMKALKPTVTPAVPRLLNRIYDKVQSDISGSCVKKTLFNMALSAKEKELKRGIVRKNSFWDMLVFRKVQEGMGGHLRLMLVGSAPLAENVLTFVRCALGCIVVEGYGQTECTAPISLTIQGDHSPGHVGPPVACCCIKLVDVPEMEYWAKNNQGEVCVKGTNVFQGYYKDPEKTEEVIDEAGWHHTGDIGMWLPNGCLKIIDRRKHIFKLSQGEYIVPEKIENIYIRSQYVSQVFIYGESLKSCIVGIVVPDVDVIKCWAHENGIPGTLSILCNNPEVKQLILDDMITWGKEAGLKSFEQVKDIYLHPDNFSIQNGLLTPTMKSKRPQLKAYFKPQLDDMYSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G388</accession>
    <name>A0A6P7G388_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114337211</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143429.1">
        <property type="nucleotide sequence ID" value="XM_028287628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G388"/>
    <dbReference type="FunCoup" id="A0A6P7G388">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287628.2">
        <property type="protein sequence ID" value="XP_028143429.1"/>
        <property type="gene ID" value="LOC114337211"/>
    </dbReference>
    <dbReference type="GeneID" id="114337211"/>
    <dbReference type="CTD" id="6616"/>
    <dbReference type="InParanoid" id="A0A6P7G388"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15889">
        <property type="entry name" value="SNARE_SNAP25N_23N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028143429.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23401" checksum="588F87D93E73E8B3" modified="2020-12-02" version="1">MPAPAAAENGAPRTELQELQLKAGQVTDESLESTRRMLALCEESTDAGTKTLEMVHHQGEQLDRIEDGMDQINTDMREAEKNLTGMEKCCGLCVLPCQKGSSFKEDEGTWKGNDDGKVVNNQPQRMMDDRNGMGPQGGYIGRITNDAREDEMEENVGQVNTMIGNLRNMAIDMGSELENQNRQIDRINLKGESNETRIAVANQRANKLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3H4</accession>
    <name>A0A6P7G3H4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 595-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114337257</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G755</accession>
    <name>A0A6P7G755_DIAVI</name>
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        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="17" type="primary">LOC114336630</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
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    <proteinExistence type="inferred from homology"/>
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            <end position="108"/>
        </location>
    </feature>
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            <position position="5"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <ligand>
            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028142797.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="13021" checksum="7A138B710F129D44" modified="2020-12-02" version="1">MVEFCPFCHNLLFVEENVQRQLQFTCNICPVFFPLTKFMSVRNFYKLKEIDDVLGGEEAWKNVDSTEETCPKCSHKRAYFMQLQTRSADEPMTTFYRCCNPECNHNWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8M4</accession>
    <name>A0A6P7G8M4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BUD31 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114339019</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145444.1">
        <property type="nucleotide sequence ID" value="XM_028289643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8M4"/>
    <dbReference type="FunCoup" id="A0A6P7G8M4">
        <property type="interactions" value="1972"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655266.1">
        <property type="protein sequence ID" value="XP_050511223.1"/>
        <property type="gene ID" value="LOC126887650"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G8M4"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028145444.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16981" checksum="90C0A9FE5B2BA684" modified="2020-12-02" version="1">MPKVRRSKKPPPEGWELIEPTLDELEQKMREVETQSHEGKRKNESLWPIFKIHHQKSRYIFDLFYRRKAISRELYDYCLGENIADKNLIAKWKKQGYESLCCLRCIQTRDTNFGTNCICRVPKSKLEEGRIVECVHCGCRGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBN9</accession>
    <name>A0A6P7GBN9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0518 protein GK23746</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335680</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141760.1">
        <property type="nucleotide sequence ID" value="XM_028285959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBN9"/>
    <dbReference type="FunCoup" id="A0A6P7GBN9">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285959.2">
        <property type="protein sequence ID" value="XP_028141760.1"/>
        <property type="gene ID" value="LOC114335680"/>
    </dbReference>
    <dbReference type="GeneID" id="114335680"/>
    <dbReference type="KEGG" id="dvv:114335680"/>
    <dbReference type="InParanoid" id="A0A6P7GBN9"/>
    <dbReference type="OrthoDB" id="6287422at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="2">
        <location>
            <begin position="561"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141760.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="88158" checksum="951D83252560D8D0" modified="2020-12-02" version="1">MEWLNSLLSSKNAKSVINSEDECDPQACYDSFKEHWHQVYKIFNRVQQLPTHDDVLGVVNHLEQMATLLLYDMKRNDKVYICQSSSRCLEHLLSENILDKLFEWSTKSGRYINAIRCEQLKLYQMLITQSRHVLLLHESFLHPLIKLLCSCEEEVFSPEVERLLVDLINQLSTLLMQHVEFIDLFFQEVKKVQSFIIFSLLIPFVHRENSTGMKARDALLLCMSLSKKNKKVVTYIAENSNFSLLLASGLSGLYSVLPNILDDILVPDWHRFTPDDVNEIKGLLTFVTSLEFSNAVAQVAHPLLRKQLQEFLYRGFLIPVLGPALLQNNVCEQVAATAYLELILRTITDTGLLHSFLQFLLNVDFDGHKLLDILIQRLKSENSQLCLVSLAMFESMVDLNCEDLMLELVFKHLKPCLHLMLSQRKMLLPLDPYCQSFEKLLTLAPRSCQFVEFSKDVYDNNHWYAVKNKQSLYGKYFPYLCDARNRITHCQMSCIVWNNLYTGEDENYDNSLGSSVDRSLSFISDEYKNEEYWKRPINNNKREITETPTITDIDQSGASAGPFLTILMDKLKNFVSNSFYINLHLTGLISRLAAYPQPLLRAYLLDCSLVLQPNVPSVFEIIGILKQQVDDYLCQQPNCVQLIKFARNVLIDREIMLVNQRKHNIEQQNFQNLEIEPFQRNSPKRRSLGISPISSFFGRRPSQVDGNSQVILTPEEVQFNKVYQKFNKDQHVALCAVLLDEWVKELSALAQEHTVAHFANLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCM8</accession>
    <name>A0A6P7GCM8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 227-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114340558</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147114.1">
        <property type="nucleotide sequence ID" value="XM_028291313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCM8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653506.1">
        <property type="protein sequence ID" value="XP_050509463.1"/>
        <property type="gene ID" value="LOC126886551"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GCM8"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002394">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000186">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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    <feature type="domain" description="C2H2-type" evidence="12">
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        <location>
            <begin position="279"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="307"/>
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        <location>
            <begin position="335"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
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            <begin position="391"/>
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        </location>
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        <location>
            <begin position="419"/>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509463.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028147114.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="58409" checksum="CCCE065EF9B1E08B" modified="2020-12-02" version="1">MEVKREFSGATCKVEIYSNKVDDPILDSFKNEIKEEPNIGSTHDTLDNLDIKEFSLNTELEDDNQLTPFEEIPRNKEGCSEENTLEIIKTIDMHSTNKKQPMKLIAKEKTFKCEICVKQFVRKRYLNQHMKIHAAENPYKCEICFKQFSGQSNLKIHLRLHTGDKPYKCEICFRQFSRADSLKHHIKMHTGERPYMCKICLKQFVHKNSFKNHMTVHSGETPYKCDICSKQFTQANYLTTHLRVHTGETPYKCEICFKQFAQSIALVRHMRLHTGETPYKCEICFKQFTQANNLKTHLRVHTGETPYKCEICLKHFTQTNNLKRHMIVHSGETPYKCEICFKQFTLESNLKNHMRLHTANKPYKCEICFKPFRDGSALKSHSRVHTGEKPYKCEICLKNFTTKSDLKRHMVLHSGETPYKCKICFKQFSQTNNFKRHMRLHTGETPYKCDICYKQFTLSNHLKHHMILHTRDKPQNSECFDVSTLKSDVGVNQSHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCT7</accession>
    <name>A0A6P7GCT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="9">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114335956</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028142055.1">
        <property type="nucleotide sequence ID" value="XM_028286254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCT7"/>
    <dbReference type="FunCoup" id="A0A6P7GCT7">
        <property type="interactions" value="1335"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656566.1">
        <property type="protein sequence ID" value="XP_050512523.1"/>
        <property type="gene ID" value="LOC126888369"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GCT7"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000039">
        <property type="entry name" value="Nucleoside diphosphate kinase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDK-like_dom"/>
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        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028133573" description="Nucleoside diphosphate kinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="11">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028142055.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18951" checksum="D0845652D3F76E48" modified="2020-12-02" version="1">MICTLLAIFYYFFRAMAANQERTFIMIKPDGVQRGLVGKIIKRFEQKGFRLVAMKFMWPSEELLKKHYADLAGKPFFAGLVKYMSSGPVVPMVWEGLGVVKTGRVLLGATNPADSAPGTIRGDLCIQVGRNICHGSDAVESANKEIDLWFTEKELVPWTPAAKTWVYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDC8</accession>
    <name>A0A6P7GDC8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">INO80 complex subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114340880</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147459.1">
        <property type="nucleotide sequence ID" value="XM_028291658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDC8"/>
    <dbReference type="FunCoup" id="A0A6P7GDC8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658701.1">
        <property type="protein sequence ID" value="XP_050514658.1"/>
        <property type="gene ID" value="LOC126889945"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GDC8"/>
    <dbReference type="OrthoDB" id="5977486at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026678">
        <property type="entry name" value="INO80E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056515">
        <property type="entry name" value="INO80E_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21812">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21812:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24237">
        <property type="entry name" value="INO80E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit E N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028147459.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26380" checksum="87464D73BFD2D49F" modified="2020-12-02" version="1">MLEGWYCRSIADEAAAAEEEERILEESKFKKEYKYLKRKFQNLVFENESFQKALRVAQKRLLVVSRDRAFLLDRLLMHEKAENSTSESDDTESSDDGEIAKPEPIKKHRRDISSHSNMHHVNSSGKVMSIAKKKRPPAPRPPKHQIPQTMQLQMPPSSSALSDGHMTPEEVERHLQAQSFMEFLPERAPPTVPTEMFSNEPSLDSESNDIGELETSPSNMGEEISIDMIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFE2</accession>
    <name>A0A6P7GFE2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114333201</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114337475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114337475</name>
        <name evidence="3" type="synonym">LOC114333201</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3 4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138854.1">
        <property type="nucleotide sequence ID" value="XM_028283053.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143718.1">
        <property type="nucleotide sequence ID" value="XM_028287917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050652252.1">
        <property type="protein sequence ID" value="XP_050508209.1"/>
        <property type="gene ID" value="LOC126885622"/>
    </dbReference>
    <dbReference type="KEGG" id="dvv:114333201"/>
    <dbReference type="OrthoDB" id="6672003at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028138854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028143718.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16184" checksum="C9FD23D104B5E90C" modified="2020-12-02" version="1">MLLEPIANTITSVEGDTPTISKCLHLFKKMVNTSLENVTKSPLLSKEEADTRAIFENRKKFAIYSVHFVANLLDPKYRGCELSSDEMTDATEVMYKVAQKMPDVDEAAVLADVVNFIAKEGLFKKAFLWNEDTIAAILASQSILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GH83</accession>
    <name>A0A6P7GH83_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114338116</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028144498.1">
        <property type="nucleotide sequence ID" value="XM_028288697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GH83"/>
    <dbReference type="FunCoup" id="A0A6P7GH83">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288697.2">
        <property type="protein sequence ID" value="XP_028144498.1"/>
        <property type="gene ID" value="LOC114338116"/>
    </dbReference>
    <dbReference type="GeneID" id="114338116"/>
    <dbReference type="KEGG" id="dvv:114338116"/>
    <dbReference type="InParanoid" id="A0A6P7GH83"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028513421" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028144498.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58811" checksum="D165042CAFA30B7F" modified="2020-12-02" version="1">MNLLLRTFVLVQSVFVLTESYKILGVCPMPAHSHFTLEFRLLKALADRGHEVVSINSHPQKEKIKNFRDVSVEEIEKPLREFIAEIFDFPKMPYISQLLRMVDFRRVVTTHTFKNKNVQDLMKSNETFDLVIMSHFVNDAMVIFAHRFKCPLIILAPGPVTPFNNFMFVNPTPSSYVANVLTSYGSDMNFWERLDNTFKNLLAEMVVHYRYLPSQDAILKDAFPDSPPLSSIIYNASLMLIVTNPSLDDPVPLQPNIKAIGGYHVLPPKPLPKDIQEFMDNSTEGVVFFSMGSNIKSSNFTLKARNAVLNAFSKIPQKVLWKYEEDLTEKPANVKIISWLPQSDILAHNNTQVFISHGGLLGTLEAIHYGVPILGVPVFWDQERNINSVVKKGFGLKLMYKDLEEKAFEKSLKEILNNPKYMENANKRSKIFHDQPMKPMDEAIFWCEYVIRHQGAPHLRSEALNLYWYQLYSMDIVAFVLACLFAIYVVLMLFIKLTIKSNRYDDKKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHD2</accession>
    <name>A0A6P7GHD2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-AMP-activated protein kinase subunit beta-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114342623</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149249.1">
        <property type="nucleotide sequence ID" value="XM_028293448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHD2"/>
    <dbReference type="FunCoup" id="A0A6P7GHD2">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293448.2">
        <property type="protein sequence ID" value="XP_028149249.1"/>
        <property type="gene ID" value="LOC114342623"/>
    </dbReference>
    <dbReference type="GeneID" id="114342623"/>
    <dbReference type="KEGG" id="dvv:114342623"/>
    <dbReference type="CTD" id="35931"/>
    <dbReference type="InParanoid" id="A0A6P7GHD2"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000139">
        <property type="entry name" value="Protein kinase AMP-activated non-catalytic subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="9">
        <location>
            <begin position="186"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028149249.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30768" checksum="CEBCB74EDC22657A" modified="2020-12-02" version="1">MLPASCPQGTGSSGPTRERQKSGEVVPASPTKEGQAFTFDKKPENKLQIQSSQDEEEPYFTKPASSYDQPRPRANTVSEGTQPVRNASKTPTVFRWEGGGKDVCICGTFSNWETIPMVKSYGDFVAIVDLPEGEHQYKFYVDGEWKNDPGNKIIEDDSGAKNNLIVVKKSDFEVFQALAKDSENAKDDSQKEFGQDIPPNKPWEKTSGPPILPPHLLQVILNKDTPLSCEPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLL6</accession>
    <name>A0A6P7GLL6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptor 143-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114340296</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146832.1">
        <property type="nucleotide sequence ID" value="XM_028291031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GLL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291031.2">
        <property type="protein sequence ID" value="XP_028146832.1"/>
        <property type="gene ID" value="LOC114340296"/>
    </dbReference>
    <dbReference type="GeneID" id="114340296"/>
    <dbReference type="KEGG" id="dvv:114340296"/>
    <dbReference type="InParanoid" id="A0A6P7GLL6"/>
    <dbReference type="OrthoDB" id="10069455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
        <property type="term" value="F:L-DOPA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035643">
        <property type="term" value="F:L-DOPA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00965">
        <property type="entry name" value="OCULARALBNSM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028146832.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="41283" checksum="84432BEB05DE4A6E" modified="2020-12-02" version="1">MADPTIQTFCCHHGNGTDMAIAIMEEFDTNAYNGVCIMSSTLGILGALYQILPREEFSNNHRWYSFSAKRGRKIIVWLAVADLLASLGVFTRSMIWLNYKNIMPSSHDDSSVVFCAVSSALTQYFYTATWVWTLCYAIDMRLILTQKDSHTKLYHLTAWLIPAFTTIVGLVLLYTPDANCHMPSTMGTTILRILPNYIATYVPILTVMIANPCLYKSSTNDMERIITSSFGQFTAKERDIIRAIKIKFSVINIVFYVCWLPNLVNGILLWALWFHLPIRIVISIWYIMALVNPLQALFNCIVYRRWSSGTERVILPWRQIEEEEEDVKNSSSSKSSEDKEEIYPLLKNTPTNSVNLYKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMM3</accession>
    <name>A0A6P7GMM3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114339950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114339950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146438.1">
        <property type="nucleotide sequence ID" value="XM_028290637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMM3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028290637.2">
        <property type="protein sequence ID" value="XP_028146438.1"/>
        <property type="gene ID" value="LOC114339950"/>
    </dbReference>
    <dbReference type="GeneID" id="114339950"/>
    <dbReference type="KEGG" id="dvv:114339950"/>
    <dbReference type="InParanoid" id="A0A6P7GMM3"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009890">
        <property type="term" value="P:negative regulation of biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1410.10">
        <property type="entry name" value="GTP cyclohydrolase I feedback regulatory protein GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036717">
        <property type="entry name" value="GFRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009112">
        <property type="entry name" value="GTP_CycHdrlase_I_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06399">
        <property type="entry name" value="GFRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028146438.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10649" checksum="085473092EE060BA" modified="2020-12-02" version="1">MDTKKMEIPAGVLMSTGTYAYVAIKGSLYANDSAVFGLNEVETKALVKKFSNSQREVINGILLSASPMQVVNALGQLGYRVVCTTGETEVVWTMQREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMY4</accession>
    <name>A0A6P7GMY4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-binding Rho-activating protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114344638</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151266.1">
        <property type="nucleotide sequence ID" value="XM_028295465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMY4"/>
    <dbReference type="FunCoup" id="A0A6P7GMY4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295465.2">
        <property type="protein sequence ID" value="XP_028151266.1"/>
        <property type="gene ID" value="LOC114344638"/>
    </dbReference>
    <dbReference type="GeneID" id="114344638"/>
    <dbReference type="KEGG" id="dvv:114344638"/>
    <dbReference type="InParanoid" id="A0A6P7GMY4"/>
    <dbReference type="OrthoDB" id="9871914at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1540:FF:000003">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1540">
        <property type="entry name" value="Costar domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026111">
        <property type="entry name" value="Abra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027817">
        <property type="entry name" value="Costars_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038095">
        <property type="entry name" value="Costars_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739:SF7">
        <property type="entry name" value="EG:152A3.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22739">
        <property type="entry name" value="STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14705">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01283">
        <property type="entry name" value="Costars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Costars" evidence="2">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028151266.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20702" checksum="431BCB25D23381F4" modified="2020-12-02" version="1">MSACVNERVFVDSPLKSKVALFNKVADKHIQGQAVNPFSNGQQAGGLHRPTISKEEYGKPPKGSLSEIRAFKATIHVSREMLELCEVISQCGERLFSPEEKPNDPRIVISFGELFAIYTAISDKVVGILLRARKYNLVDFEGECLFQRQDDHVPIILVKPISEIRTFLKERIATATKALKETGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GYW6</accession>
    <name>A0A6P7GYW6_DIAVI</name>
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        <recommendedName>
            <fullName evidence="2">BUD13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114344686</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151312.1">
        <property type="nucleotide sequence ID" value="XM_028295511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GYW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650684.1">
        <property type="protein sequence ID" value="XP_050506641.1"/>
        <property type="gene ID" value="LOC126884624"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GYW6"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028151312.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="73336" checksum="6D7EEB46E7FC906D" modified="2020-12-02" version="1">MSTINQKEYLKKYLKIGAKTGEKKKKKKSEKTAGTRMKIIDDDVDTLLSQEIQDDIDAANEDAPQIVAVIDERPHSLIVDEKTNNTLWKPIGQASNNSEFQNFKIGSIKLNKNRDDSEKHRLLGTKSFSSSKRNDNLPSTSTSNNYNKLKDKHAVSKGNGNFPIKESTYSYNEKNYSPPRRDQDYSPQRKRDIDQSPKRREEDYSPPRKRKQSHSPVRKKDQDSSPRRKVNKDSDYSSPRRDDKDYSPPRKRNKSYSPRRKKDQDCSPQRKDNKDSEKDYSPPRRDNKDYSPPRKTDKDYSPPRKRDQDHSPLRKKDQDYSPQRKRDKDLSPLRKRDQDYSPQRKRDKDLSPLRKKDQDYSPQRKRDKDLSPPGKRDQDSSPQRKRDKDLSPLRGKHSPPKDKSRKKRSRWEKEDSPASKEPNKPETTMSGKKSGLQNAKNLVDEIARLQKEEDEMFQKMSSEMSGFNAAPVVRKRKPEEIVDPEKEAREKELKEKYHVWGKGVKQVEDESQRYAEQQKEMNKPLARYADDEDLERYLKEQEREGDPMLAYIRKKKKKVAVEHGIPEKPMYIGDFMPNRYAIRPGYRWDGVDRSNGYEKKWFETQNAKQAMQEEATKWSQEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9B6</accession>
    <name>A0ABM5I9B6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calponin homology domain-containing protein DDB_G0272472-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127895.2">
        <property type="nucleotide sequence ID" value="XM_028272094.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272094.2">
        <property type="protein sequence ID" value="XP_028127895.2"/>
        <property type="gene ID" value="LOC114324291"/>
    </dbReference>
    <dbReference type="GeneID" id="114324291"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF18">
        <property type="entry name" value="ENSCONSIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="878"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1225"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1259"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="450"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="841"/>
            <end position="874"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="909"/>
            <end position="923"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1232"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1259"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1311"/>
            <end position="1324"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127895.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1324" mass="152813" checksum="F4DEFB64CE56CE15" modified="2025-10-08" version="1">MAENSRKLSKQPKSTVEKELRLRHLKDRQNGEKQRKLQEIKPQAPAVQVFKEQERFRRLDDLKYRDDERRIQVEERKKRIQKAERDRLEFILRRNQEREQRFESRRRNERNNTVFAFGSSTPRMLDPNDVIASYWNTGRSSSIQNIVTSTNPSMLTRRQPERKQDAGTKKHAISATGLARTGETSSLPRSSLNKQSTTSFANSESVRHRLTTAPKNSIPVSGISSDTKGNNKPPLLKTKKLLAKPTTRQKVVLKSKTKTRVESCSNDIAKLNKSEKPQVAIPLPKPETHVLTEPKLVVRDIRDIISIFYLPQTTKSDLESPQVKKFEENSDKTEPILVELEDKKDVGEKDKKDVMEIETVKMSEPETNDTDVTEIQKFEQVQLIIDESYTSSEVEIRSVIEKPEQKHFLQENSVEPKKPESTSEAQIVVDNNTIENIENKMTISMTKVRINTAEEDIAALAERRRLISEEAARQAELEMLRFETEAKAELERQQREEEQIRELIQFHRESEQQRLKEAIKETQRREEEEKLKKEEKLRLKFLKEEVKKKFKEPSSSLTQQSTTSFANSASVRQRLTTAPRKPRPVSIAITGISSGTKGDNKPPLPMTKNILAKPTTSKNVVLKSKTKTPVNSFFNNTTKVSKSEIPQVEIIPPKPDIYVLTEPKLVTKDIESNVYVPQNTKSDLESPQVKKLVEDNDKKEPILVELEDKKGVMKIGTVNMSEPEKSDTNVTEIQESEQVQLSIDESHTSSEVEIRAVIERPEPESLLKEKPVEPKKPESTSEAQIVVDSNTIDNIDNEMTTSMTKVRINTEEEPKAAIAERQKLIRGEVKGQAKLERLRNNSKVKEELERHQREEEQIRELRELQRQTKQERLQGVIKETQRYEEKEKLKKEGELRLTEEAKKKVKEPSLTQESTTRFTNSASVRHRLTKAPRKHRPVSRISSDTKCDNQPPLSKSKKLLSKPTTSKNVLKSKTKTGVDSSSNNTTKVSKFEKQSVAITPPKLETHVLIEPNLVTRDIKSNVHVSQTPKRVLESPQVKKLEEDSEKTEPILVEFDDKKDVEEQDKKDIMKIETVKMSEPETSDIHVTEIQKSEQVQLSIDESYTSSGAEIRSLIEKPEPEPILQKNPIKPKKPESTSEAQIVVDSNTIENIEKKMTTSMKKVRINTEEEAKAALAERRRLIREEAERQVELERLRIEAEAKAELERQQREEEQTRELIELQRQMEQQRLQKAIKENQRRKQEEKLKNEEELRLKLLKEEAKKKAKEDAQRQKAKLRERLKTEEVERQARRKKVEAIMSRTRGKNATPQSVDENKSDNIKSEVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE07</accession>
    <name>A0ABM5IE07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase-like protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130748.2">
        <property type="nucleotide sequence ID" value="XM_028274947.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274947.2">
        <property type="protein sequence ID" value="XP_028130748.2"/>
        <property type="gene ID" value="LOC114326555"/>
    </dbReference>
    <dbReference type="GeneID" id="114326555"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051720">
        <property type="entry name" value="rRNA_MeTrfase/Polyamine_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23290:SF0">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="3">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130748.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="24225" checksum="3B9BBA47FD7DBB6F" modified="2025-10-08" version="1">MFPCLKLKRLEERLQCISEFDKPKILLEQYITPWHLGSHMLYTVQSQYGDIDGKLVADLGSGCGALTIGAAVLNASLVIGFEIDEDAIHICQENIEDHELSNIDIVQCDVLKGVPSRFYKSFDTVLMNPPFGTKHNAGIDMKFLEAAINLSRNTVYSLHKTSTRSFILKHAESLGVKAEVLAELSYDLPSTYKFHKKKSVDIQVDFYRFTVPNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIQ8</accession>
    <name>A0ABM5IIQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">39S ribosomal protein L41, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133750.2">
        <property type="nucleotide sequence ID" value="XM_028277949.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277949.2">
        <property type="protein sequence ID" value="XP_028133750.2"/>
        <property type="gene ID" value="LOC114328954"/>
    </dbReference>
    <dbReference type="GeneID" id="114328954"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133750.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18562" checksum="19F33BF08B5106EC" modified="2025-10-08" version="1">MSSVNFFIKRSLSTTSIRYGKRNFRKFPIYNKRGTRIFKQQQMQNPDPEVPVHKRGVREVGYEERDKFITIPERIPELIVPDLRNCQLKPYVSYRAPEVFQSEFTAEDLFNVVYAPKIVKDFNEGKLADDGQPLEPSREEKITAEEAKNKAKQTGTDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPX0</accession>
    <name>A0ABM5IPX0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138435.2">
        <property type="nucleotide sequence ID" value="XM_028282634.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282634.2">
        <property type="protein sequence ID" value="XP_028138435.2"/>
        <property type="gene ID" value="LOC114332855"/>
    </dbReference>
    <dbReference type="GeneID" id="114332855"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045194416" description="Lipase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138435.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="398" mass="45745" checksum="5FE96743F02FADB7" modified="2025-10-08" version="1">MTFKKNVIVAFCVYLFVFVCESKYSPRYNVMELTNQLGLTAELHNVTTEDGYILKIFRIKAINGKEQENREPVLLQHGLLGSSEQFLHAKNNSLALILFNNGFDVWLGNSRGNFHSRKHVSLDPDRDKEFWFYTLDQMGQYDQPAVIDHILKTTGKQQISYIGHSQGGGSLLAMASGRPEYNQKIKIFVGLAPAAYMKHNRHPLLVISKYFADLLKDLIQFLNVYEMEAVSNSEFFSKIMQGACGEKVNYRINCRPVIDFLSDSLTSLFDYSLAPEIFTTTPAGMSFFQILHYAKMHIHGTFEKYDWGPEMNLQKYNSTVAPKYDWSKITCPTVLIYGLSDALVNHKDIKYIAKKLPNLIELYKVADDRFNHLDFLWSNNITPLLHDKVLTILNNYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRM9</accession>
    <name>A0ABM5IRM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139790.2">
        <property type="nucleotide sequence ID" value="XM_028283989.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283989.2">
        <property type="protein sequence ID" value="XP_028139790.2"/>
        <property type="gene ID" value="LOC114333990"/>
    </dbReference>
    <dbReference type="GeneID" id="114333990"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046845168" description="DUF19 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139790.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24476" checksum="E0C45B0F2259519C" modified="2025-10-08" version="1">MGQGLPFYLFLGLVHHFYLLDDLVHLNRPNCDIKRINEARTNVDICLRPEYNYTQIDFLIHGPKDDPYTFVQQRCSLKPVLDNCLHKTVDYLSVCFNDTMNQGLEVWKNIDDNMVEYLCKNNAEVALELFNKTSSECWATTVTQAIRECTRSLDASVPLYDAQGLSRSCSKSDEMIKCFKSHLERHCSDKVVAIGTTITSFIKNGFCSNQGKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISJ0</accession>
    <name>A0ABM5ISJ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquilin-1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140642.2">
        <property type="nucleotide sequence ID" value="XM_028284841.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284841.2">
        <property type="protein sequence ID" value="XP_028140642.2"/>
        <property type="gene ID" value="LOC114334753"/>
    </dbReference>
    <dbReference type="GeneID" id="114334753"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01808">
        <property type="entry name" value="Ubl_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="544"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140642.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="65313" checksum="7BAED4D94DD525AC" modified="2025-10-08" version="1">MADDMPNNSETIPDVSLNTPQVPPMHMEVEEPSPELPLPPPPTDSEAVIKNLELVPELSSELPVQLPSELPVQLPVQEQSVQPEQPPVEQQIVPEVPISETEQVAVAPEEIVQEKPPEEVVPEKPPAKMISIHIKTPQERETFEVEENAGVKDLKAVIAPKFNAEPDQLCLIFAGKIMQDEDHLLQHNIKDGLTIHLVIRAAPRLSEQANRRPADIGATPFQLGSLGGLAGLNQLGLSSPTFMELQNQMQSELLSNPNMLRNLLDNPMVTQLMSNPEVMRNLLMRNPQMQNLVQRYPEIHQTLNNPELLQQTAELARNPSMLQELMRSHERAMGLDPSSPIPTSNPVPNLFQNLQEPMLSSLAAQYQAGAQTNPGRGVLNPPPLASLLQQMSENPTIIQNMLQAPYTQSVLEALSADPSVANALLAQNPLISDNPTLQEQMRAMMPQLVQQMQNPEIQNLMTNTQALDAIMQIQQGMESLRQAAPTLIHTFPPPAPQPLNTGTPASQTETSTQNPPAGAPRDAFSEFMSRMVGSMAANTNNTLPPEQRYQAQLEQLAAMGFLNREINLQALISCFGDINAAIEKLLSQGQLSSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IV29</accession>
    <name>A0ABM5IV29_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143143.2">
        <property type="nucleotide sequence ID" value="XM_028287342.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287342.2">
        <property type="protein sequence ID" value="XP_028143143.2"/>
        <property type="gene ID" value="LOC114336952"/>
    </dbReference>
    <dbReference type="GeneID" id="114336952"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143143.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="189" mass="20908" checksum="C2AE73A398B93E9C" modified="2025-10-08" version="1">MSLETRAAKSGLAAETQKRVNAKYSEDLAKESLEWIVTITGDELNTAGDMDNFYEVLKDGTVLCKLVNNIQPGIVKKINTSTMAFKCMENINAFLEAAKQLGVPPQETFQTVDLWERQNLNSVVICLQSLGRKADKYGKQSIGPKEAEKNERMFSEEKLRAGQTIIGLQMGSNKGATQSGINFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWG5</accession>
    <name>A0ABM5IWG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145371.2">
        <property type="nucleotide sequence ID" value="XM_028289570.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028145372.2">
        <property type="nucleotide sequence ID" value="XM_028289571.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289570.2">
        <property type="protein sequence ID" value="XP_028145371.2"/>
        <property type="gene ID" value="LOC114338947"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289571.2">
        <property type="protein sequence ID" value="XP_028145372.2"/>
        <property type="gene ID" value="LOC114338947"/>
    </dbReference>
    <dbReference type="GeneID" id="114338947"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39960">
        <property type="entry name" value="LD34147P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39960:SF1">
        <property type="entry name" value="LD34147P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028318" evidence="3">
        <location>
            <begin position="21"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="901"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145371.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="911" mass="102170" checksum="4CE05EC3F17F1D2A" modified="2025-10-08" version="1">MVASVVFFLVILIGITNTEAVVTNEDIRVAILQIVNVVRATGDKLEKHEYRDRVLGEQLKKGLVNIDKRIKMLDPLKGTVGRLDERLAAVETILMQTNEREKMQLQRTYEAVIDIQKNLPVIMEEMKNEIISKISANEPPAQITEPVMSKKDFEKMEKEVMNKIDKVTNTIGKIENEISKIKTDNQQVKDLHNKSSDNLEKLKRHFNDSQQLLNKYDKKLGDYNSKTGNKENDEWKNNVIKALDGQKSSIKDISQDLKNLHGQVKQLPPKDVINKLQNSINNCQDASLKQALHKIEGILNKSHDESTKTLNVLTKFTNTFNKSLDNTNYAINSQKSSAKDILQNIKSIQNQLHKLPQIEELATSQRETNKKLEITMKNIDNVRDVSNMVVGTTNNILDNCSKTNNGLDSQKSLQEILNNVKNLQSQRQNIPQIDQLAAAQRAAVNKLDDAVKNIHGLTEVTATLMKSIANTNSALDVQKSNTQEILNNIKNVQNQLPQINELSAGQSTAINKLEDTLKNINGLTEITGTLMKSFANTNNALDLQKSSMQEVLSNIKNVQNHLPQINELSIGQRNARNTLEDILKNINGLTEITGTLMKSFANTNNALNGQQSDVKEILTDVKNIQNKINQLPQRYDLDLHQNSSLQKLNQLSADVSVCKQQSSNEVRHILESIINNINKTHEDTIEKLNDLSEITAALGQSFVTNYDQIRNEIKGLNRLDQVMINTADGVIDTKRKVEFGVHQILAEISKYSKETTKHVQQAVSNRLDTFETSILDPDTGALANSTSKIEDDIQQVWRQIGIMYQQMSSNSQALKQLQNQTDAYITGSLGTMNNVKGKVGQITGRITEVDENLNYLIGRLSLVTEEFNRIKTGLSSALEKIKESFHAVQEKVDEGPGPHNIDSSEQVPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWH7</accession>
    <name>A0ABM5IWH7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apyrase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145384.2">
        <property type="nucleotide sequence ID" value="XM_028289583.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289583.2">
        <property type="protein sequence ID" value="XP_028145384.2"/>
        <property type="gene ID" value="LOC114338958"/>
    </dbReference>
    <dbReference type="GeneID" id="114338958"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF10">
        <property type="entry name" value="IP19903P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045313040" description="Apyrase-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145384.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21302" checksum="3A4FEA3049F7811C" modified="2025-10-08" version="1">MKTFVLSLSLLALVYGNQEDYLKWVSYNGEIPKDAVPAGMDADNNTVYIGRVHLITNRAEGFVPGNINPGVVSLDTVLFNQVYTATENIEILTAVNNPKLEWILVKEYQFPKLFDHEEFHVARVGWELAKGEFNSTIYLGRTHFNDRTNIGKVFTSANFYAENNELYFAANSKTKTGYVFEALVYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWI7</accession>
    <name>A0ABM5IWI7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145406.2">
        <property type="nucleotide sequence ID" value="XM_028289605.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289605.2">
        <property type="protein sequence ID" value="XP_028145406.2"/>
        <property type="gene ID" value="LOC114338979"/>
    </dbReference>
    <dbReference type="GeneID" id="114338979"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145406.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17717" checksum="AF22FC6D4BFC8C04" modified="2025-10-08" version="1">MLTPGEDVNKNPNGDNVTGIRRRRAGVYKMVDITDGMLFKNNGFLSTLNIGKRYHLHTMPRNYKKIGVTAKFRYNEIYIKNALKAVTRGQMSIRAASTNYGVPYTTLHIKYAAHVKGEEQRIIGGQPVLSEIEEKKIVKIYLRTFWFVQSRMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWZ3</accession>
    <name>A0ABM5IWZ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146156.2">
        <property type="nucleotide sequence ID" value="XM_028290355.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146157.2">
        <property type="nucleotide sequence ID" value="XM_028290356.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146159.2">
        <property type="nucleotide sequence ID" value="XM_028290358.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146160.2">
        <property type="nucleotide sequence ID" value="XM_028290359.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146161.2">
        <property type="nucleotide sequence ID" value="XM_028290360.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146163.2">
        <property type="nucleotide sequence ID" value="XM_028290362.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290355.2">
        <property type="protein sequence ID" value="XP_028146156.2"/>
        <property type="gene ID" value="LOC114339689"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290356.2">
        <property type="protein sequence ID" value="XP_028146157.2"/>
        <property type="gene ID" value="LOC114339689"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290358.2">
        <property type="protein sequence ID" value="XP_028146159.2"/>
        <property type="gene ID" value="LOC114339689"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290359.2">
        <property type="protein sequence ID" value="XP_028146160.2"/>
        <property type="gene ID" value="LOC114339689"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290360.2">
        <property type="protein sequence ID" value="XP_028146161.2"/>
        <property type="gene ID" value="LOC114339689"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290362.2">
        <property type="protein sequence ID" value="XP_028146163.2"/>
        <property type="gene ID" value="LOC114339689"/>
    </dbReference>
    <dbReference type="GeneID" id="114339689"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028319" evidence="3">
        <location>
            <begin position="25"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146163.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="779" mass="90634" checksum="9B5569A49E3758E5" modified="2025-10-08" version="1">MVGKSSIIYLAYIFLTLQSPLVNSRINYKVMVEEDIIRIHSKSCTDETAVLPTMCKKDLTYIGDASCTFKELNGTGRFILKDAVVNLTTKSNFTYFYWYIHKKWHFLKISLFNGSCNVWVIEQQLKTSEAKVCLDKLSQNVLNEQFPQKNISNEKERHRDRYRIMVDNENILTHLISCNDKTTVIPSMCKKDLTYIADHSCPFKELNDISKFTLKDGIVNLRTKSNFTYLYWYMYKKWYFFKTNLFNSSCNVWVIEQQLKSSEVELCLDKLSENQNDEHLPRKNISNKQEIHRDRYKIMVDKENILIHSLSCKHRSTIPSVCQKDLKYVGDASCPFKELNDIQAFTLKDDIVHSTTKLNFTYLYWYINKSWYFLKTSLFNSSCNIWVIEQQLKSSEVELCLDQLSENLRDEQFSQKKISNEKDIHRDQYKIMIDKKNILIHSVSCKDKTAVIPSVCKKDLTYIADASCPFKELNDISKFTLKNGFVNSTTKSNFTYFYWYIYKKWYFLTTSLFNSNCNVWVIEQQLKSSEVELCLDKLSENLEQISRDQQVSPKNISNEEEVHRDDANTQESSVSKLIYTNTTAKKNLVSSTSAPSIKETTDKNWLKGVLILTVVTLLFLVLLLICTSNSCLGYDFWKRIVLICWYGSQNYLRRVYTHLWEQQMCLPKRPYVAKGSFPFKMEEHPLSPSQCVLNRDQGNILLPHSSVSVRNLSNTPLPDSTLKNVRCSPVRDPSNTPLQSDSPIISEKCAQCSSTRCLEHARLLPPKISPRNNHTCSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXX1</accession>
    <name>A0ABM5IXX1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148030.2">
        <property type="nucleotide sequence ID" value="XM_028292229.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292229.2">
        <property type="protein sequence ID" value="XP_028148030.2"/>
        <property type="gene ID" value="LOC114341432"/>
    </dbReference>
    <dbReference type="GeneID" id="114341432"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="83"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="421" mass="48804" checksum="78A3C7DC6F505635" modified="2025-10-08" version="1">MYGKRTRSNNNIIMPPIFDIYRKPIFDESIRKAEYRTYAPFIKSFYCNDIVEFSINQVYSFFAMSETLLCIKGSLEITGNGDVTLANNVGAFLFDSCMYSESAREMETVRDPGIVSAVRAMTCYTQEDSNYMVMAGWNYPKDPILNAADHSFSIQMPLKHVFNIFNDYPLITCGRQTIRLVRARNDNDCVVIKEKQNADKTTTVTTAKINITNIELRVKHIFPNDDIKLELMKSTQQDQPIVIPFRKWELHELPAITRGARREVWAVKTSTSVERPRYVIVFFQTNKRDKTTADPTLFDNVNIQSIRLSLNGEYWPNERMQLDFSKTDYNEAYFNYTEFYPSYIHSQQKRPLLDFSAFKTHALFVIDCSKQEESMKASTVDVKLDIEANNGFPDNTKAYCIIIHDCVMEYFPLTEIVKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0F4</accession>
    <name>A0ABM5J0F4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155595.2">
        <property type="nucleotide sequence ID" value="XM_028299794.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299794.2">
        <property type="protein sequence ID" value="XP_028155595.2"/>
        <property type="gene ID" value="LOC114349421"/>
    </dbReference>
    <dbReference type="GeneID" id="114349421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22133">
        <property type="entry name" value="F-box_FBXW7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="455"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="495"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="535"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="575"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="618"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155595.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="719" mass="79989" checksum="D4E6AA816A4452E5" modified="2025-10-08" version="1">MAECISRNSDLPKQDCTSPSPTETVCLESLCAENHPSTSQSNIEQPLIPQNDNYNIEEVEKLEKSNFLNELGLVQECDDEEDEIDVVLKLEIDVDDNEEDDTNSRDDKWEDCLDEEFPDEVNTENSEEVSSSDEINSFSGSHSNTPRSSQLKRSNSSSVERILRKRKLDINNGLPMLPCKKIPPDSPPLHNNGGCLLSPTSSASQTYSGSNTPSSGRSRAIIPTKENPPPDLSNWLIRFTTWSNAERIMAINELIASCEPTQVRHMMQIIEPQFQRDFISLLPKELALNVLSFLEPKDLVRAAQTCRSWRVLADDNLLWKEKCKQAGIDEIPKKRMSSRSPNSCHMSPWKATYMRQHAIEMNWRSAPIRPPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSATTGKCLRTLVGHTGGVWSSQMSGSTIISGSTDRTLKVWDADTGVCIHTLYGHTSTVRCMHLHGKKVVSGSRDATLRVWDIETGNFLYVLVGHVAAVRCVQYDGRLVVSGAYDFMVKVWNPETQECLHTLEGHTNRVYSLQFDGVHVVSGSLDTSIRVWEVETGACKHILKGHQSLTSGMELRNNILVSGNADSTVKVWDIVTGQCLQTLSGPYKHQSAVTCLQFNKRFVITSSDDGTVKLWDVRTGEFIRNLVALDSGGAGGVVWRIRANDTKLVCAVGSRNGTEETKLLVLNFDIEMLSDGTIMSASNCHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHA8</accession>
    <name>A0ABM5JHA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497323.1">
        <property type="nucleotide sequence ID" value="XM_050641366.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641366.1">
        <property type="protein sequence ID" value="XP_050497323.1"/>
        <property type="gene ID" value="LOC114342587"/>
    </dbReference>
    <dbReference type="GeneID" id="114342587"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08718">
        <property type="entry name" value="RGS_RZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="129"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="272" mass="29976" checksum="AEB6978C75EE959B" modified="2025-10-08" version="1">MSCGLTERRQNNRAAGPQGGGGPGGPAGSACRLRGTGTNNAAATNARGSTPITTAPQNGPQPSAQGPPLRAKPCCLLWCCCCKCPCSNPGGKASEENGPNINSNNSDLMVNCELEPPPTLEEVRNWGRSFDKLMKSAAGRQVFRDFLRVEYSEENILFWLACEELKRETNLEVVEEKARIIYEDFISILSPREVSLDARVREIVNRNMVEPTPQMFEEAQLQIYTLMHRDSYPRFINSPLYRSLSQQQSGSSDPEPDETTAMVNMVSEDQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHL2</accession>
    <name>A0ABM5JHL2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497428.1">
        <property type="nucleotide sequence ID" value="XM_050641471.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641471.1">
        <property type="protein sequence ID" value="XP_050497428.1"/>
        <property type="gene ID" value="LOC126878643"/>
    </dbReference>
    <dbReference type="GeneID" id="126878643"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="516" mass="58935" checksum="601F471973ABEE64" modified="2025-10-08" version="1">MIESKDTKHSYLVHRRIAKEHFADIYPSYHKLREAKLRCYPRKEGQTVSESCAEILLQDLLDHTVKRIVELQKPVLRSLSTELLKNLKLLLKWGCDGSTGHSQYKQLFSDNSFGDGDLFLTSIVPLQLYAEQPGQDKIIVWQNPRPSSTRFCRPIRFQFKKETKELTVQETSYIENQISELQPTIGMLDSEEIAVSHVCVMTMIDGKVCNAITETASSQTCYICKATPKQMNDIEKLLKREVVQENLKFGLSTLHAWIRFFECLLHISYRLEVKVWQIRGSNNRAVFENKKRTIQQIFRDRTGLLVDIPKSGGSGTTNDGNTARRFFADPSLSSEITGIDKDVIMRFGIILRTLSCGYAIDVRAFEEYCLETAKLYVAKYSWYYMPSSVHKILLHGAIVIKEAILPIGQLSEEAQESRNKDLKSFREKHTRKISRISGNQDLLNRLLITSDPVISSLRQYPLRKSLNISSEVVSLLKAPSLESMEADSLRALQLNMESRQVSSSDEEDDSASDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIM9</accession>
    <name>A0ABM5JIM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497794.1">
        <property type="nucleotide sequence ID" value="XM_050641837.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641837.1">
        <property type="protein sequence ID" value="XP_050497794.1"/>
        <property type="gene ID" value="LOC126878967"/>
    </dbReference>
    <dbReference type="GeneID" id="126878967"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="265" mass="31845" checksum="E4807205C0624053" modified="2025-10-08" version="1">MGIPIDDDRLYTIHFADDQAILAEDESDIDYMLRKLKEEYTKWGLTINIQKTEYLVVGETPERLQIEIGTINPTEVFKYLGVQISSKAGSNDEIHSRIGQARSATRQLHGLLWSNKITKENKRRMYKTITESIGLYGAELWEINQRNKSKIKAMEMNYWRRCCRLTRLDRVRNEDIRRQMEIDLDIIDTIEAKRLNWYGHLQRMPENRWPKKIEKWTPPTRRKRGRPRRSWREDVEDAMTARDLKTEDCFDRNRWRLGCEKRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ59</accession>
    <name>A0ABM5JJ59_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497973.1">
        <property type="nucleotide sequence ID" value="XM_050642016.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497974.1">
        <property type="nucleotide sequence ID" value="XM_050642017.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642016.1">
        <property type="protein sequence ID" value="XP_050497973.1"/>
        <property type="gene ID" value="LOC114327987"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642017.1">
        <property type="protein sequence ID" value="XP_050497974.1"/>
        <property type="gene ID" value="LOC114327987"/>
    </dbReference>
    <dbReference type="GeneID" id="114327987"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="2">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="355" mass="40668" checksum="6EE856E6F041178C" modified="2025-10-08" version="1">MARSNRSSAYEEEIEVHPSTELIPDEYEHFGNQPKFLVHTFFKDTEADKDNEKDFLKTLSEIGITCKDEDRHNLDQEKIFEILNRIKENCSDDTTGLIMYFSGMVKQHQGILHTKLPSNDISIQKIWLEFNSFNCFKLKNKPKIFIYDLKVYAPPTQRDARRFSVQSLTISAYDTPSEADILVICNKDTEEDDSQFTLQFCNNIKSDGDKENIITLASCVGSLTSPIIISTLTRHFYFTPSELRGHHLVIHKDQQQLKEHVEDIHNLMKNNKLVEHKKKHGILDSFREVFRKSDANKSTSPSTSATVSDGPPSESNKPPSSQQKRPSGPSSTRSRKMSQSEPEGSRSSTKRPPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLS6</accession>
    <name>A0ABM5JLS6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498892.1">
        <property type="nucleotide sequence ID" value="XM_050642935.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642935.1">
        <property type="protein sequence ID" value="XP_050498892.1"/>
        <property type="gene ID" value="LOC126879723"/>
    </dbReference>
    <dbReference type="GeneID" id="126879723"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="218"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="37184" checksum="0890FA28194252CC" modified="2025-10-08" version="1">MVIKYKKAVSYKIFSMVRSICIRYGVKLIAKMSSMKIVLSEKGKQLIVLNGFKYRFHKSLKNNDKRWMCSAQTREKCKAFLKTQDDNVVTEIRDEHNHSELNEDALNRQMLSNSLKRKAVEDIGERPMKILQKELRNGHISTLTTKDVALVRKNMYNARRSLLPKLPKSMEETHDILKTFPVKTNKNEDFLMVNDIENQIIMFSCSSNLEFLADLDTIYIDGTFEYCPKFFKQMFSIHGLKENHYIPLVFFLLPNKEKHTYTLALALKYLTEQLKKCNKKLALRTVFADFEEAIQQSVTEAWTNVSLKGCRFHLGQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPU6</accession>
    <name>A0ABM5JPU6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499961.1">
        <property type="nucleotide sequence ID" value="XM_050644004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499962.1">
        <property type="nucleotide sequence ID" value="XM_050644005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644004.1">
        <property type="protein sequence ID" value="XP_050499961.1"/>
        <property type="gene ID" value="LOC126880213"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644005.1">
        <property type="protein sequence ID" value="XP_050499962.1"/>
        <property type="gene ID" value="LOC126880213"/>
    </dbReference>
    <dbReference type="GeneID" id="126880213"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="115" mass="13138" checksum="AAB77D76BE80500A" modified="2025-10-08" version="1">MEQHTIICRTCCVGGCTFSTSITFSRDEMDMFLEGLKLIQIFVFVLGILKMILRYMRVRTRGITKGAIPSSFLPPLGICKRPMHELKEMTRDRDLFRQTIYDITSTTTLPPGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ82</accession>
    <name>A0ABM5JQ82_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500096.1">
        <property type="nucleotide sequence ID" value="XM_050644139.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644139.1">
        <property type="protein sequence ID" value="XP_050500096.1"/>
        <property type="gene ID" value="LOC126880337"/>
    </dbReference>
    <dbReference type="GeneID" id="126880337"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="268" mass="31271" checksum="35450BAADFBAE92C" modified="2025-10-08" version="1">MKKINTVFKIIHFVSICFGTASFISLLSNANCYDHLIPLLIKDLFFNYNFVKVAIYGFLIPHTCVFTFATMFIATYFVMHFKFLMQCLNEDVKQFIEEDTENRRSDINDLQYQNYVRQQITHICIKFVRIKGDVDALNLFIKWRCVSFIFTGALACGGEVICVLITNGNQGTYYMGMAFGSILIFFIGSEIGHQLQIESENLLTNILRFKWYQWNKANCEMFIILLLQIQKPVVIKCFAFPYINRELLLSVFRIVHGYIACFQSMKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQX2</accession>
    <name>A0ABM5JQX2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500340.1">
        <property type="nucleotide sequence ID" value="XM_050644383.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644383.1">
        <property type="protein sequence ID" value="XP_050500340.1"/>
        <property type="gene ID" value="LOC114333859"/>
    </dbReference>
    <dbReference type="GeneID" id="114333859"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="745" mass="87489" checksum="2E7C23B35E029220" modified="2025-10-08" version="1">MEVKQEISEETCKTEIDNHLDDALLDDFKCESEIKEESNYWQSTHDTYDSVDLKKCPINTEIEQHGNKLNLFEENQKTEKGHLQDEIKTEIMEKLIEDSSYEGNDMNRHNEGKTLNKNMQVVTEKRPYKCDTCFKQFSNVSHLKKHLRVHTGQKPYQCEICFNRFSDTSSLKRHFRLHTGAKLYKCEICFKQFSDKSSLKTHLRVHTGEKPYKCEICFKRFSVAGSLKSHLGTHTAEKPYKCEICFKRFSDASNLKRHFRLHTGDKDYKCKICFKQFTTTSNLKTHWRVHTGEKPYRCEICFKRFSDASSLQRHFRLHTGAKPYKCEICFKQFSDASTLKKHFSLHTGAKPYKCEICFKRFSQAGHLKCHLRTHTAEKPYKCEICFKQFSQASALKTHLRVHTGEKPYKCEICFKQFSQAGDLKTHLRVHTAEKPYKCEICSKQFRQPVTLKIHLRIHTGEMPYKCEICFKQFREARTFKIHLRLHTGETPYKCEICFKRFSAAGSLKRHLRVHTGEKPYKCEICFRRFSESGSLKSHLGTHTAEKPYTCEICFRHFSDASNLKRHFRLHTADKDYKCKICFKQFSQAGNVKSHLRTHTAEKPYKCEICFKHFSQASALKTHWRVHTGEKPYKCEICFKQFSQAGDLKKHLRVHTAEKPYKCEICFKQFSQAGALKTHLRVHTAGKPYKCEICFKRFGQAGNLKRHSRVHTAEKPYKCEICFQQFSEAGKLKTHLRTHSGEKLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRK4</accession>
    <name>A0ABM5JRK4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="3">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARM1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050500565.1">
        <property type="nucleotide sequence ID" value="XM_050644608.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644608.1">
        <property type="protein sequence ID" value="XP_050500565.1"/>
        <property type="gene ID" value="LOC126880616"/>
    </dbReference>
    <dbReference type="GeneID" id="126880616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09501">
        <property type="entry name" value="SAM_SARM1-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24153">
        <property type="entry name" value="SARM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039184">
        <property type="entry name" value="SARM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998:SF1">
        <property type="entry name" value="NAD(+) HYDROLASE SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22998">
        <property type="entry name" value="SARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="766"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="836"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="915"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1118" mass="124280" checksum="7519329ED504AE66" modified="2025-10-08" version="1">MEDEKVLVPVREKRKHKFLEKLKLQGVAKDNKIVMGISKSDVSSPKSQPFTPESLSPTVSSPKSQCKQLDAESIFQTVSSPKFQLLTPESLSPTMASESPTDNNANGTEPPLQTIVKNPSRTTVTTTSLQTNSQSSTTTTRVSKTSTSASTTSQRRQLTDLKASNMKSDLVDFKNNINDMKSSLPNTLLQIRNSLENLVDAEENDPIVTFPDDTPVPSEIGSPTNAVESLKFEQKTTNNFKKTTVMKDGISAEKESAKMAEMKILQAGDVSYEENNAARATRARVEIDGVSAEKSQVMAKEARSLKAGDLSQQESKNLAQTNMKVTTDKFSSERTAMESQQQRQTVTASGFYNQEKHSSSTSHIYTSSSSKGLSTSAKINATRQFHLLNGTPEEAILNTSLEDLDSLSATSDVHDIERAKHKYSTYLDESIRCLQKLDQNKDAPLVLDKINDVMRKAWAVPTYGHELGYALCNALRNSGGLDLIMQNCTKSDKSLQFASAKLLEQCLTAENRAHVVEHGLDKVVNVACVCTKISNSVDHSRVGTGILEHLFKHSEETCSDVVRLGGLDALLFECRKSDVETLRHCAGALANLSLYGGTENQEAMIKRKVPMWLFPLAFHTDDNIKYYACLAITVLVANPEIEAEVLQSGTLGLVEPFVTTHNPSEFAKSNLAHAHGQSKTWLKNLVPVLSSKREEARNLAAFHFCMEAGIKKQQGNTNMFSEIGAIESLKKVASCPNAVASKYAAQALRLIGEEVPHKLSQQVPLWSVEDVEEWVKQIGFPEVAISFVESRVDGDLLLQLTEENLRDDIGLTNGIKRKRFTRELQQLKKMADYTSRDTSNINNFLQTMGLEFSIYTYSFLNAGLDKKDYLRNISEDQLLTECGISNSIHRLRIMEGIRQLENGLANGMNEDNQDKSLDVFVSYRRSNGSQLASLLKVHLQLRGFSVFIDVERLEAGKFDNNLLQSIQKAKHFLLVLTPNALERCIGDIERKDWVHREICAALSANCNIIPIIDNFIFPELEQLPEDMRQVCHFNAVRWIHDYQDACVDKLERFMRGEANPRGDNYRVTLPKGDITPGTPSNPSLVRQPPNYQRMHSNDSGSGKSSDKDMNGNSGLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSE0</accession>
    <name>A0ABM5JSE0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500862.1">
        <property type="nucleotide sequence ID" value="XM_050644905.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="HATC_C_dom"/>
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        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
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        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
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            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="738" mass="83751" checksum="D04E065A69C3F0DA" modified="2025-10-08" version="1">MDNSKPKQKTLTSFFSASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEGKLGCKVCFEVTTMGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKDIFRSAYYIAKNDRPYNDHFGLLELQKLNGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVSGKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYSKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFLTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVFAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUL2</accession>
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        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_050501627.1">
        <property type="nucleotide sequence ID" value="XM_050645670.1"/>
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        <property type="protein sequence ID" value="XP_050501627.1"/>
        <property type="gene ID" value="LOC126881406"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
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            <begin position="10"/>
            <end position="50"/>
        </location>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501627.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="100" mass="11019" checksum="1945533F0EB4AEBB" modified="2025-10-08" version="1">MPRKRAPWSKEDLRSALQAIADGMSIKGAAKSYNIPRSTLGLHHRTQNPVKKLGRSPVLSAAQENDLVEKIHRLAEKSVLLLIAVLQCVILTWVATIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWC2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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            <taxon>Pterygota</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_050646284.1"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="IGLOO, ISOFORM A"/>
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    </dbReference>
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        <property type="entry name" value="zf-POGZ"/>
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        <property type="entry name" value="DM3"/>
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        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
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            <end position="101"/>
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        <location>
            <begin position="2031"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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            <dbReference type="PROSITE" id="PS50950"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2092" mass="235012" checksum="8699559E97C8147C" modified="2025-10-08" version="1">MKKLSCIVPDCDSVDSQHDGANTKFHQFPKEAEVRKKWLKAIKRTEGEVNKRSKVCSRHFKTDDYAITRLNYGVGGKPTASGSKNTCEFKALKSEAVPNMNLPPKSTFKIKISKKDNSKHIKVEEIKVKEEKIEKPERVKMPKRPAPPDSPPRSRTGSRPSRAASKEALKQMQLLLDDENDAVEIPDDVMPIAPSPPMGPPPKKKHKVSHRKSADATAKPAPTDRDTIVLQTITNRDAENTLELDCWVEQPDQIHKDRRKKYLDEQKELQDKLDALVAENHGKVIFKNETSTIIEVLEQVRSAVEGAEKPPTSVIINNNLGGTQSYNLVMDPTAGLVASAPIQITPPVVTPALVAVTPQKAPQARISVVQDLQQTPPPAPTTPRVATRNRARGSTSKNTPPPPAPVATPPTRSKATPAQSTPPVQAPPTRNQTRAQVQTTPAPKPPPATPQTRGQVQNTPQTRGQNAQTRGQNTPRAAQIPTPTPTQTRAQAAAATPPTPTPTPPQTRGKKQVNTRARGVPGSNTFTTTVRPSETNVEGGLSAGNKNQVVEVDLTSTDDTETSKLPPDSREIAFNKLQGKTYPSLVVVARPHLRAKDLSLDRPKLDAKVKSVLMHAPPKFTEWLIQQGLIRSEQKCTVHTSTQLKLGMYSDVSKFPYSGGYVWISECCPQRFVSVFSGSLFEGSPHPPVVILKLLYHWACQTNIQNVVQWVKVDNLYVKGMFTWLRSICTVGLQSHFRQLGGPGVKVEVGVISLGTSSQDGSTRQVKVEVLGVLEADSKLIRLRAVEPQSDGDRSYKKRFSKILEPLVSWVHPHSMLVADMTVDKQALYNMGFTNVVVSTVVTNNQIMEYLRRIVPRMFQNTLSLLSRQIIQQFLDELVWREWFGTSSLQAFDSVVQHLAEQTRYESGMSLIVRLNKVAQNPFKSWNMGLPNTPKIPVENNAINATNATNNSKKSRNARKPELPKVNQVTPTDVNRPPKSTSPDVPEQMVPLESYYYGTIETYTKTPKITLNMKCPFCKSVFDNNIQLMSHLFKHAHNVSMDAQLCRYCLTSVATANDLLKHIATSHPAETKFDNGFCCLICETPYMNPFILGKHMSKEHSPSELPYQCGTCGYRCSNHKQAIDHFYKAHDNGPTIQCPFCLKSTTVFTSSRNIVQNMNYFIQHLQKHQRKNLARRCGKCNSWFVQKDALNDHQKKMHISQRGKPELVPWTAPRNGIMVPKSKMDKYPVDAEVIDFDALKLDLSKGLMCKECDTPMDTPKHFPSFESCQNPNCQYSTCCTNAMQEHNAKCSKTNNPIAEEKLPFEMFCICGFSNTDGNRMAKHLATCERKSAYPSRADARSATVTHSMLDVLGLVRRAEEIPKPTDTTKSDDSKPKPKTEKRKRAKNEEESTIDGANANKDSVEVLTIDEKEDEVEVNKRKRRRLLIQKKESTGDVITVVDDKDEVNKKDGNDIEKTKTTDKPEIENKDVEQPLAEDKSSDSKSKDETLETEEKLKQDDTPQPMEQNATENVDDTSEPMEQNTTENVDESVTDTPKDGDDVQPSENVEAAASENEQSANLQNHVDDSENTSEEKQEMEEDKENLADSTDDKSQDTEIVDKDTEETNLTKEHELEDKDGTDINKKEEDTSSKSIEQDKGDENDMENQTDDKLHDDERDNEESVDKNVPEDKNGDSLEGESKEEDLLEEERSKEDNVEKSNVENLEEESRENEECQEEDLRENDVSQEEESQDNVQNVDKDDKEEIGDEGESKDNESLDDKDYSEESQEVQNKHEEEAKIDEDELKVQSEKEAETQDEAMEEQEEKQVDDDQELDREDETTEDKVDVAEDDEEEVNEDKEEDVVEEKDAAVAEEKDEAMAEEKDESMAEEKEEDEAEDNKDVNEDIEDVLLEEEDVIDNKEKDTVEDKEEEVAEEHEGVDEDREEINKDEEDDESQEAEDVHKGEDAVTNDEELNEITEKEQDDLESSEKQSEDLNASEKQSEDLDVSEKQSEDMDVSEKQSEDFDVSEKQSEDFDTSEKQSLDFEGPEDPTDLQNHVTNDNTNEAERPTYKQPKFSSDDIHDLLSNVVGETESDSKNPNVDSGGDGSTPMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWK5</accession>
    <name>A0ABM5JWK5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050502312.1">
        <property type="nucleotide sequence ID" value="XM_050646355.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646355.1">
        <property type="protein sequence ID" value="XP_050502312.1"/>
        <property type="gene ID" value="LOC114328627"/>
    </dbReference>
    <dbReference type="GeneID" id="114328627"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="100"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="272" mass="31003" checksum="8975145381312CAC" modified="2025-10-08" version="1">MNKYLPPILSSDPCGIVCILITYIAVFYADYVIIKWVVLQTMLDSLWGTFNVVMFNTIIFFLIISHIKAVVTDPGTVPLPQGRIDFSDMHSDSGCEFVNWTVCARCETYRPPRAHHCRICQRCIRKMDHHCPWINNCVGERNQKFFIQFLIYVGTLSVYAIALVAISWMKECKDCSEDIPLKETRILHSIILLLESALFGLFVAAILIDQLQAILSDETAVEQIQKQGPYRPYKPKMALLGEVCGKEHPLMWLLPCSSVPKKVDVPLIDHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY35</accession>
    <name>A0ABM5JY35_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein OZF-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502845.1">
        <property type="nucleotide sequence ID" value="XM_050646888.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646888.1">
        <property type="protein sequence ID" value="XP_050502845.1"/>
        <property type="gene ID" value="LOC126882063"/>
    </dbReference>
    <dbReference type="GeneID" id="126882063"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047084777" description="Zinc finger protein OZF-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="52374" checksum="6EDA63266D5FC84A" modified="2025-10-08" version="1">MFFWYLKILKTLVVCLNKNALVDIFKTKYQETTFADIFTMVFILEINPTDYLPKKICTVCENLVIEFYKFSEKVKDTQIILRNSLMLIQEQEEQKNENTETLETDKFDYISDDGTNQECSHIVLKTLEKTITCSFCNSQFETYSAYIAHRKMEADSRRKKQHCSVCKKFISTYKLKDHMNSHTKEKPHQCQICGEKFRFLSSLSRHKFRHRDKKPHVCHICGKGFIQAPCLNDHIRTHSGEKSCMCNVCGITFITKHALGNHINMHKVKDSNNSSQLTCQKCNRSFLSKYLLKQHLQTHYEKEFLCSQCGKKFATKALLDSHVKVHSEVKPYICDICEKAFCHKNSLLKHKKSHSGEKPAICIVCGKKFSQKSHLTYHMRKHSGERPYSCNFCEKTFDHSGSLKIHTRIHTGEKPYKCDVCLKSFYDCSSMKKHTKQHSSEYRHFLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYE6</accession>
    <name>A0ABM5JYE6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">NADH dehydrogenase subunit 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion inner membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502955.1">
        <property type="nucleotide sequence ID" value="XM_050646998.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646998.1">
        <property type="protein sequence ID" value="XP_050502955.1"/>
        <property type="gene ID" value="LOC126882178"/>
    </dbReference>
    <dbReference type="GeneID" id="126882178"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30015" checksum="97AEB1DAFD7B6945" modified="2025-10-08" version="1">YLFLNDLILIIISSLILIVCVLVSIAFLTLLERKVLGYIQIRKGPNKVGFLGLIQPFSDAIKLFTKEQIYPFISNFNLYYFSPILNLFLALFLXICMPFISINVTFNLTLLFFLSVSSLRVYTIILAGXSSNSNYALLGRLRSIAQTISYEVRLALILLSFLFLIISLNILDFIKFQEYIXFFYLFFPLCLIXIVSGLAETNRTPFDFAEGESELVSGFNVEYRSGGFAIIFLAEYGNILFIRIICVFLFLGANLIRLIFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ50</accession>
    <name>A0ABM5JZ50_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050503210.1">
        <property type="nucleotide sequence ID" value="XM_050647253.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647253.1">
        <property type="protein sequence ID" value="XP_050503210.1"/>
        <property type="gene ID" value="LOC126882361"/>
    </dbReference>
    <dbReference type="GeneID" id="126882361"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044980275" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="4">
        <location>
            <begin position="56"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="291" mass="33077" checksum="22EE80918F51A6AD" modified="2025-10-08" version="1">MQCLLLFVVILYVTDVNTQLLQLKNFKVGECTYQGERKQSPEPSPCSSSKTTKLRNASPNAALWDDGRVPYILKGSFTDRQKSILEKVMGLYKYYTCIKFVPKTRNDKSYAKIINEVNTCCSEIGKVPGGGFTVVDLGPRCFEEEEAGTVIHELMHLIGFYHEHNRSDRNDYIELTLANVNPNYTSEFDIESGNTFNIPYDYDSTMHYGPFHGARSYSHKIFVPKDKSVSESRLGQICGFSKRDITKINILYNCPQKTAELNLKDDLLYGVDISTAEQVKYEKNVNQCTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K060</accession>
    <name>A0ABM5K060_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503575.1">
        <property type="nucleotide sequence ID" value="XM_050647618.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647618.1">
        <property type="protein sequence ID" value="XP_050503575.1"/>
        <property type="gene ID" value="LOC126882643"/>
    </dbReference>
    <dbReference type="GeneID" id="126882643"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="233" mass="27176" checksum="3F581A136ED112A2" modified="2025-10-08" version="1">MRAHTGEDPFECEICNKLYSTQSNLTMHMKLHSDEKPLECGICAKQFSTKGNLKTHMKLHTDEKPFKCKICNKQFSAKSNLKTHMRVHTGEKRFKCETCNKQFSAKQILTSHMRVHNKDLFKCEICNKGYSTQSNLTMHMKMHTDDKPFKCGICRKQFVTKQILQRHMAVHTGEKPFECGICNKQFITKQVLQRHMAVHTGEKPFRCVICTKNFSTKYVLKSHMRVHTGEKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K173</accession>
    <name>A0ABM5K173_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050503939.1">
        <property type="nucleotide sequence ID" value="XM_050647982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647982.1">
        <property type="protein sequence ID" value="XP_050503939.1"/>
        <property type="gene ID" value="LOC114326737"/>
    </dbReference>
    <dbReference type="GeneID" id="114326737"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="358" mass="40958" checksum="526449E46AA6F196" modified="2025-10-08" version="1">MEPYNIHTFYTFDTEYSADSVEWCPHEPNQNIFVCANYQLVDNPTESTTKKRVGRLLLFSIDSDYGLKLLQTIDTPAILDQKWCHKKLWNCSVLGVTNAERKVDIYKLNNETLQLELVTSCDVDTDVSETLVLSLDWSTAIPDSDKLEISCSDSKGNIHILELVNDTLALKESWHGHDFEAWITGFYYWDTNIIFSGGDDSMFLKYDRRLGSAPVSKNRSHEAGVTSFHSNSSKEYIVVSGSYDEHIRLWDIRRMKSEIESLKMPGTLWRLKWDPFNHDKLLAACMLGGVHIVDTSNSHKMEIIASHYEHKNIAYGADWSYLSKKESARFEGTGEHIIGSCSFYDHLLCISKVNVDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2B8</accession>
    <name>A0ABM5K2B8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504332.1">
        <property type="nucleotide sequence ID" value="XM_050648375.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648375.1">
        <property type="protein sequence ID" value="XP_050504332.1"/>
        <property type="gene ID" value="LOC126883128"/>
    </dbReference>
    <dbReference type="GeneID" id="126883128"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25044" checksum="34EDD2C5AF485F50" modified="2025-10-08" version="1">MHDKNKPRKGVQIGGEYEESESSDDDPQTETQNSVDIHDLEDEPERSKVENSATPLETDKFCMQNASTSNAPENEFTSKNQPKKKTNRNVEKDNESESTQVFNMMKSVYEKKERDEYDVFGEMVANNIRSLKTEYSRITVQQQITNILFDARRSHLPQSSCTPMPSPSTPSWAVISDNSSASAMSGQKVQVITLSETNDFNPIQGETSILKEAFSSLFQDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K310</accession>
    <name>A0ABM5K310_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504567.1">
        <property type="nucleotide sequence ID" value="XM_050648610.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648610.1">
        <property type="protein sequence ID" value="XP_050504567.1"/>
        <property type="gene ID" value="LOC126883278"/>
    </dbReference>
    <dbReference type="GeneID" id="126883278"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="235" mass="26687" checksum="856FA9067FDC1320" modified="2025-10-08" version="1">MSKKILFSHALYQATLAVNASSNTKYIILTDSLSSVQSIQYVYPSNPLVIKIKQEVHTAQLNGKIIIFLWIPSHIGIQGNEEADNAAKEAATSDSAECTITFTSADVKAAVKRKVRYMWEEKWKVSSAKLREIKKSIKPWPTLPTSRRDQVILTRLRLGHTRLTNSHVFSYKQEPRCDNCEEKLTIKHLLENCAALTPKRILYNIPNKLSDILGLQCNMSNLKRFLSAINILYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7I1</accession>
    <name>A0ABM5K7I1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506147.1">
        <property type="nucleotide sequence ID" value="XM_050650190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650190.1">
        <property type="protein sequence ID" value="XP_050506147.1"/>
        <property type="gene ID" value="LOC126884257"/>
    </dbReference>
    <dbReference type="GeneID" id="126884257"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="287" mass="32255" checksum="56371AD1F5030EC2" modified="2025-10-08" version="1">MKAAWALIENDFDNNIFTYGCFAHSLNLIFTDLKNLTSLKSFIAEAVALTKAIRQSHILSAWVKEKQNELKISCSLKLPVPTRWGSLDRVQGYIMLLEPIANTITSVEGDTPTISKCLHLFKKMVNTSLENVTKSPLLSKEEADTRAIFENRKKFAIYSVHFVANLLDPKYRGCELSSDEMTDATEVIYKVAQKMPVVVVNFIAKEGLFKKAFLWNEDTIAAISPIAWWSGLCSNTALSKLAIRFLELPATSAACERSFSSYSGIHTNKRNRLTNTRASKSCMWLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7M6</accession>
    <name>A0ABM5K7M6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506194.1">
        <property type="nucleotide sequence ID" value="XM_050650237.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650237.1">
        <property type="protein sequence ID" value="XP_050506194.1"/>
        <property type="gene ID" value="LOC126884297"/>
    </dbReference>
    <dbReference type="GeneID" id="126884297"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="279" mass="31464" checksum="CCDB5D1B80C08431" modified="2025-10-08" version="1">MPRKRAQWSEEDLRSALQAIADGMSIKGAAKSYNIPRSTLGLHHRTQNPVKKLGRSPVLSAAQENDLVEMIHRLAEVGMPITSKVLMKSVFSFAITNRIPNPFSKESNKAGRKWLKLFLCRHPDVARRKAQQMNMARAQKMNKTIVDDYFHKLRDTIEKLNLFDKPGSIYNIDEIGCRLTIHKQQIVFARKGAKRVHLTAPEHGENVSIVGCGNALGQAIPPFVLFKGQRFKPEWSDHLPPGSKAIVTNKGSMTCEAFISWLDHFSSFKNPGHTLLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K998</accession>
    <name>A0ABM5K998_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506763.1">
        <property type="nucleotide sequence ID" value="XM_050650806.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650806.1">
        <property type="protein sequence ID" value="XP_050506763.1"/>
        <property type="gene ID" value="LOC126884698"/>
    </dbReference>
    <dbReference type="GeneID" id="126884698"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="465" mass="53327" checksum="8F97A15E002F4B61" modified="2025-10-08" version="1">MTSPVALYLCRLCLNKTPTRVNIFGGDFPRMLEILTSIKVDEEDGLPKYSCIKCAKEVQMCLMVKKRIIKAHQFLLEGLKKKKTTFESTVITRIVNKGESSVQNKTKTAKQKVVSKKSNPVITQNKTQCKSKLFDNSNEAATDEDAYDNSNEATTDEDANEGSVKHDVKTEGVETTNQPNAIKEEKESLDQEVHEILDEDQKCIESTGFTCETCNLTFSDKQKFNLHSLKHKKSQCHICSRIVRSGNLKKHIRLHTAGPSVCSTCGVTFKNFESLRGHIFHYHKHTAHQYICEECGKSFRIKYSFLLHKRKAHIGLRNFKCNTCGKAFITNANLLRHVRMTHEKLRPHVCEYCGTGFFCKRVLRAHTRQHTNEKPFVCQHCLEGFRQRVSLRTHLKSKHGIEEAKEFFCKTCEKGFATNFALNIHQRLHEIKKCEICSANFGGDEYLTKHLREVHQVKVEIKQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9Y2</accession>
    <name>A0ABM5K9Y2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">39S ribosomal protein L12, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506993.1">
        <property type="nucleotide sequence ID" value="XM_050651036.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651036.1">
        <property type="protein sequence ID" value="XP_050506993.1"/>
        <property type="gene ID" value="LOC126884797"/>
    </dbReference>
    <dbReference type="GeneID" id="126884797"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19575" checksum="3B671F9ED7256879" modified="2025-10-08" version="1">MQSVRLILRPLQGYRRISNCAALCQSVEAQTNPVEKIQIPPPSNVEQPVSPKIDKLATEISKLNLIEVSELSSVLKKRLNLADAPVFPAGGFAPVAAPAEEEDAAPKKEKSVFTVKLMKFEEKQKVALIKEIKALVEGMNLVQAKKFVEGAPAVVKADVPKDEAEKLKAAIEKVGGVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC53</accession>
    <name>A0ABM5KC53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Histone-lysine N-methyltransferase 2C-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507765.1">
        <property type="nucleotide sequence ID" value="XM_050651808.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651808.1">
        <property type="protein sequence ID" value="XP_050507765.1"/>
        <property type="gene ID" value="LOC126885295"/>
    </dbReference>
    <dbReference type="GeneID" id="126885295"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15665">
        <property type="entry name" value="ePHD1_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15509">
        <property type="entry name" value="PHD1_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15510">
        <property type="entry name" value="PHD2_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15512">
        <property type="entry name" value="PHD4_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15513">
        <property type="entry name" value="PHD5_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15514">
        <property type="entry name" value="PHD6_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19171">
        <property type="entry name" value="SET_KMT2C_2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="257"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
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            <begin position="373"/>
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    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="420"/>
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    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="503"/>
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    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="708"/>
            <end position="761"/>
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    <feature type="domain" description="PHD-type" evidence="16">
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            <begin position="758"/>
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    <feature type="domain" description="PHD-type" evidence="16">
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            <begin position="835"/>
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    <feature type="domain" description="PHD-type" evidence="19">
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            <begin position="4745"/>
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            <begin position="5126"/>
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    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="5266" mass="582966" checksum="4618C8AF227197D4" modified="2025-10-08" version="1">[encoded data, 5266 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFC2</accession>
    <name>A0ABM5KFC2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508868.1">
        <property type="nucleotide sequence ID" value="XM_050652911.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652911.1">
        <property type="protein sequence ID" value="XP_050508868.1"/>
        <property type="gene ID" value="LOC126886069"/>
    </dbReference>
    <dbReference type="GeneID" id="126886069"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="255" mass="28471" checksum="335F841062891E5E" modified="2025-10-08" version="1">MTKGDMDVKQKENIQHLTAGSQSYIQIEIDDNLEPRNANDLSTTNEVAEEEQISQNDATTELIGTNSKTPASNGEHLPVLPQCSWMPDPVQIPSGKSNLTSFPTASPQHVLPIPKVEQNKKRTSRKKGKTAILTLSPYFEELKKAKEETKTKAAKKVERVKRKVSFSKDGSKATKEKVVKKKRVLLNKDLKDKTRNSDSSDTEDDAECLYCQDFYSTSNEGWVACSSCYSWAHNSCADVDSEDDESVFICELCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIE6</accession>
    <name>A0ABM5KIE6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509991.1">
        <property type="nucleotide sequence ID" value="XM_050654034.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654034.1">
        <property type="protein sequence ID" value="XP_050509991.1"/>
        <property type="gene ID" value="LOC126886900"/>
    </dbReference>
    <dbReference type="GeneID" id="126886900"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF272">
        <property type="entry name" value="OVO-LIKE ZINC FINGER 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="46866" checksum="5E026D80FFC79576" modified="2025-10-08" version="1">MLAMEFKVESKEEFLEYNQKDTESQLDTCIDLKNFKNDNDSEMGFKAEIKEECVDSYQGYIGSPLHASLDIKELDNKADENNPGFSQNEMEIMKTELECTKEQQISANIEETTLNNYICKICFKQFNRARYLKLHLRVHTGEKPYKCEICFKQFTQKAHLNGHLRLHIREKLYKCEMCFKQFTQLSNLKKHLRIHTGETLKCEFCFKQFTRESDLKRHLRVHTGEKPYQCEICFKPFTELGNLKKHLRIHTGETPYKCKFCFKQINRESDLKRHLRLHTGERPYKCEICFKQFNTAGELKVHLRAHTGETPYKCEICFKQFSQKGALKRHLMTHTGERPYKCDICFKQFSTAGQLNVHLRVHTGEKPYKCEICFKQFTHKITLDRHTKVHTGENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ16</accession>
    <name>A0ABM5KQ16_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pupal cuticle protein 20-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512284.1">
        <property type="nucleotide sequence ID" value="XM_050656327.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656327.1">
        <property type="protein sequence ID" value="XP_050512284.1"/>
        <property type="gene ID" value="LOC114325722"/>
    </dbReference>
    <dbReference type="GeneID" id="114325722"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046612264" description="Pupal cuticle protein 20-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="20755" checksum="8C5FFCA5D5E5FC01" modified="2025-10-08" version="1">MSNMRLILATLLVGICSAARLDNTYLPPGAKGAGGGPGLTAPFGPGGGGSRPGGGGGGGGGGGGGGGGGGGGGGGGNGNGDVIPIISQENVPNNGDGSYKWSYETGNGIKAQEEGELKPGGEEGIQSAVGSYSYTAPDGTEIKIEYTADENGFVPVGDHLPTPPPIPPEIQKLLDDIAAEGANGGGNGNGNGGGYPGGNGGGNGGGNGGGNGGGNGNGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRY6</accession>
    <name>A0ABM5KRY6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512957.1">
        <property type="nucleotide sequence ID" value="XM_050657000.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657000.1">
        <property type="protein sequence ID" value="XP_050512957.1"/>
        <property type="gene ID" value="LOC126888641"/>
    </dbReference>
    <dbReference type="GeneID" id="126888641"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="227" mass="25002" checksum="3E4AFC7F19538597" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYIVASLDTAYTLEVRDIIVSTPATDRYAKLKSELIKRLSASQQQKIKRLLEHEELVDRRPSQFLRHLQSLAGTTVPDNIVRSLWLGKLPASTTQAILSTQAKASLDAVAELADTISEAIAPRAQISEASNILESTIAKLTAELADMKIQQLDAGSSTNKHMPSQPQQLKTKTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSL1</accession>
    <name>A0ABM5KSL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cathepsin L-like proteinase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513173.1">
        <property type="nucleotide sequence ID" value="XM_050657216.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657216.1">
        <property type="protein sequence ID" value="XP_050513173.1"/>
        <property type="gene ID" value="LOC126888817"/>
    </dbReference>
    <dbReference type="GeneID" id="126888817"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38121" checksum="E3C88791BCA8D4C9" modified="2025-10-08" version="1">MKFTDNFSMKTIIIFATVFLSVYALSDQNVWNSFKVNFSRSYKVKEDKLRFLIFKKNLREIEKHNVKYHRGESSYYLKITEFADWTDEEFNRLIKRNNTSINELLENVERRVNLEVSDDDLPTSIDWRTKNAVTSVKSVFDFDLICCAGYAFSACGSLEGQLAIHSNQLVNLSAQELLDCSSWNQGCESGMATWSFYDVEAQGLCSEEQYPYKGLDADCLKDVITSPTLAKTKEHVELNANETTLYNAVATIGPISSLINGTNLRFFGGGIYDAECEGFPNIDVLVVGYDTSDGVDYWILKNSWGISWGEEGYIRIPRNKNQCGIMYLNSYPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUB4</accession>
    <name>A0ABM5KUB4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513785.1">
        <property type="nucleotide sequence ID" value="XM_050657828.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657828.1">
        <property type="protein sequence ID" value="XP_050513785.1"/>
        <property type="gene ID" value="LOC126889493"/>
    </dbReference>
    <dbReference type="GeneID" id="126889493"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="194" mass="22546" checksum="6057F826BBCC6FAB" modified="2025-10-08" version="1">MQYILTEEVKSWIQQSVGTENCIITIENTTQKLKGYAGEFIFAKVELQSSEGMVTDDKTLFIALKRNNQNPLVQKRISVMHEFCRREVYFYGTVIQAYQKFYKNKILQGDLCIVPKCHEAFLEGENNVVVLENLKRKGYVLHQTEKPLNSNQIKLCLQSYAKLHALGFAMRDQNPEQFKMISEELHPLISQKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV18</accession>
    <name>A0ABM5KV18_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514028.1">
        <property type="nucleotide sequence ID" value="XM_050658071.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658071.1">
        <property type="protein sequence ID" value="XP_050514028.1"/>
        <property type="gene ID" value="LOC126889600"/>
    </dbReference>
    <dbReference type="GeneID" id="126889600"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21911">
        <property type="entry name" value="CC1_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="696" mass="79328" checksum="9063C69CA630ECCF" modified="2025-10-08" version="1">MVVVSGNWVKNVATYSPTNVIDNVVIVESMAAKAILTSRPNSHHFQERTLALDQPVKVGRAVARAKPAANNAIFDCKVLSRHHALLWYENGKFFLQDTKSSNGTFVNNSRLSPDNGHHELSSGDIVQFGVDVIENNRKVTHGCIIATIKLYLPDGKEAKASPISDGGTHGMVPLDDLYRLNQIIQEANQREQCLETKLTALQQVVYDTKKSAEESWQAYVGEERLLSRVSALETQLQRANKNWGEERFREELTRLQEDHEAYQISAKEALDKLHAERLEAIALAEDQERLRISTKQEAFLAIKQFTQAQTELEEVAKRLSEQQLEASEQKIKLEQCIQDLEMKLEAKSANLLTLQIELQNINALNLPGLKNLGSLVSDTQLDLIYKENDMKCKEDILSENEDSESLMNQTNGLGSHISLTVGPVEEKYEWEEHESEPNADEKNSNDLRNEPQEEVKRVTFKIPEEAEMEQEKEDPSDDSEEPIERTDAVDSKTLKYQFHAAQSELKRKIETLETIANAHRSKIEELDKALEDEKTLSNDRLAENDVLKQELVLLRQKWKESANENQQQKDRLSALNLELESALENMRVTALHRENESTTEKSEKTLEQEKVEPIAEPNLQKAVVPVDQLAQVEEELVLIKERYAQVSEEKLSLRHDLATLKGQYDAMCNRFYNQFFWYVAPLVVMVLYLLISAMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXR2</accession>
    <name>A0ABM5KXR2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514983.1">
        <property type="nucleotide sequence ID" value="XM_050659026.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659026.1">
        <property type="protein sequence ID" value="XP_050514983.1"/>
        <property type="gene ID" value="LOC126890173"/>
    </dbReference>
    <dbReference type="GeneID" id="126890173"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="100358" checksum="6C1E958AF3A3BD7E" modified="2025-10-08" version="1">MTVPKYDDVAFRNFTYTQTTPFIIYADFECQLHNFTDSNVKLSKTTKYQKHVPYSAGYYFKCAYDDGLSYFRSYRGENCMEWFAKEMAEISKFVNSKIKSIVPMVKKPSTSTATACHICEKRFLAKDIIVVDHDHFTGEIRGFAHQACNLNFRKVFVVPVAFHNFSGYDSHFMIIDLCKHGHLSLLPINKEKYISFTLHSDENKIRLRFIDTMRFMGASLDELASLLDTSEKKILKQEFYSLDDDAFNLLTCKGVFCYDYVDSLEKLEETSLPTISHFYNKLCDEHISEQKYAHAQKVWSTFECKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYHLDPAWYYTIPGYTWDCMLRYTKCRLELLKDVDMILFIEKGIRGGISVCSNRFSEANNKYMPTYDPTQPSKYIMYLDVNNLYGWAMSEYLPFGGFKWIEDVTKFGVASKSTKLPKGHIDIMSIPNAAKEGYFFQVDLEYPLELHDKHKDFPFAAEHRIPPGSKLPKLLPTLFNKSKYIIHYRNLKQALSNGLILTKIHKVLKFNQSAWLRPYIELNTNLRAASKSSFEKNLYKMMNNAVFGKTMENIRRHRTVKICKNWNGRYGAKNLIASIRFHSRTIFSENLVAIELTKSVVCFNKPLYIGAAILDISKLCMYDFHYSFMLPTMGEENCMLLYMDTDSFIYELQCLDAYKEVLKVHNSKFDTSDYSENNPYMIERLNKKIPGLMKDEANGKIITHFIGLRSKMYTFKLQTTDEEREKERERLKLKLNKEQIDCGIQNLGITKKAKGVKYNVVKNIITFEDFENCLKECKIKSTNQRCIRSYQHSVFSIEQTKTALSPYDDKRYLIPESFKTLPWGHCDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY05</accession>
    <name>A0ABM5KY05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515074.1">
        <property type="nucleotide sequence ID" value="XM_050659117.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659117.1">
        <property type="protein sequence ID" value="XP_050515074.1"/>
        <property type="gene ID" value="LOC126890259"/>
    </dbReference>
    <dbReference type="GeneID" id="126890259"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35333" checksum="754ECD7DDF13D070" modified="2025-10-08" version="1">MDKLLRPDRFDADPNSSRSSQEWTHWKATFENFISSVVGVSEEDKFKLLVNYVSNNIYELISDCTKYSEAKSILEALFVKPKNEIFARHMLMTKRQQTGENIDQYVQHLKVLSKECNFLAVSADQNKEDYIRDSFISGILSNDIRQRLLEKNSITLKDAILKAQSLESASKHSEAYITPVQIINAISSETTEQTNYTSAAVKSWKCYFCGATERHPRILCPARDKICKRCSKVGHFFKSELCNEQFIKDPPSPRSSDTCEENTNISPVNVLEEGGIETDSREENKDIFIRRGTRERNAPAYLQDFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0R8</accession>
    <name>A0ABM5L0R8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516034.1">
        <property type="nucleotide sequence ID" value="XM_050660077.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660077.1">
        <property type="protein sequence ID" value="XP_050516034.1"/>
        <property type="gene ID" value="LOC126890911"/>
    </dbReference>
    <dbReference type="GeneID" id="126890911"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24633" checksum="3636D1F408480319" modified="2025-10-08" version="1">MGSIDDDIILAAASFIILSKKKKRKHKYWVRPSLIGRNTHGGIELINALRKDDLLAGRIEDGQIRNFLRMTDSDFEWLLNLVGPKITKNYTNFRKAITPTERLLITLRFLATGDSYTSLMHLFRISKQAISKIVPEVCIAICEVLGDQIKMPGTAEEWKVVATQFNNLWNFPQCTGVMDGKHIMIQSPEHSGSDYFNYKSFLALCFLLLLMQMCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L270</accession>
    <name>A0ABM5L270_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516541.1">
        <property type="nucleotide sequence ID" value="XM_050660584.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660584.1">
        <property type="protein sequence ID" value="XP_050516541.1"/>
        <property type="gene ID" value="LOC126891412"/>
    </dbReference>
    <dbReference type="GeneID" id="126891412"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="79"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="46846" checksum="6FDE7701969A90B6" modified="2025-10-08" version="1">MNGSILNVNKTVPVDESIINSEYHTHLPYSATSLDNNDEIRIPIQSQNIYTYPSESYIILEGNLISQEKGHYSTKLSFINNGFLHLFEECRYELGGTIIARSRFPGITSTLKGYASFTPNDCIKNANSDWSITEHPKIVEPTTGYFNVCIPLKQILGFGEDFKKIIINLQQELVLVRSHTDFNATITTDGATDTPKVKITKIMWKVPHISVSDEQKLVLLQHLEMQNNLEISFRNWSLQKLQVLPKTKSYDWTIMTVKQSEVPRYMIVGFQTDRENSKTRDNSDFDHCNLTNLKVYLNSEVYPYDNLNIDFKKKHYAIAYEMCARFQESYYFQGKSEPCLSLTNFIQKAPIFIIDCSHQNEAVKGGAIDVRLELESSENFPDNTSVYCLIIHDRTVIYNPLSNLVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2I9</accession>
    <name>A0ABM5L2I9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516659.1">
        <property type="nucleotide sequence ID" value="XM_050660702.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660702.1">
        <property type="protein sequence ID" value="XP_050516659.1"/>
        <property type="gene ID" value="LOC126891525"/>
    </dbReference>
    <dbReference type="GeneID" id="126891525"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="328"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="713"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="96223" checksum="96C2881B6C42EC74" modified="2025-10-08" version="1">MGFYQNIAYRYGDLAVRALKDWSKTKQKLAREYNKRCFLLRCRSSNISPTHIIHSTSSITKLLQRQDIQSNKDALQFTRLENRILNLEISNCIKVINNLESNLSKLKRDIIDFTSEFIFNNFSSKQQVLYNKTFHKTKLVNTNKYNRLFNQELNLKLKTKPGWIKNLSNVTLPDDISRFLSLGPKFSIEPIVGKDIPIRDMLADVETIMHSVTDAQLRDVLVAKSTYIITDYVHKNNSKSSFNFYRAMLHKTRKFLSENTNIIVMPSDKCNVTVVLEKQGYLDLCLELLNSDNIYERLNRDPTNTVQTKCNNLIKELCSSGQIDDDTKKKLTGYKGVIPKFYALPKIHKPQLSVRPIVACIGSPTNLLASFLTEILTNAYVSNEYDVKSSFDVFNSFNNYQLPEGYVIISLDVVSLFTNVHLDAALIAVENNWNFISSHCNISLESFKKLISFLFNNTYFTFNNTVFRQTQGTPMGGTISPILACYVMDHLLDMVIPELSFYIPFVKKYVDDLILAIPSNRSAEILQVFNSYDPLLQFTIEHEDDLCSVPFLDTRFIRTHNNSLRIDWHRKPHSSGRFLNYWSYHRHSIKINLIKQMKARIIAISDPSCHQKNLRILSNLFIDNSYPKHLVTKILFSLTPDIIRHNDELQITVTSGEQNANCLYTSLKYVKGITPRLARLFKDIPNLKIAFKTSLTSRSIFSKVKDKSDIRDCSNVVYQIPCNNCNFLYVGQTARNLGSRLVSHRSDSRLYPERSALAEHVNKEHHKMNYESVRVLASESNYTKRLFLEMAFISQNSHAMNKRSDINQLSSIYSYLLCLDNYPHFNDVLSTDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L373</accession>
    <name>A0ABM5L373_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516901.1">
        <property type="nucleotide sequence ID" value="XM_050660944.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660944.1">
        <property type="protein sequence ID" value="XP_050516901.1"/>
        <property type="gene ID" value="LOC114326941"/>
    </dbReference>
    <dbReference type="GeneID" id="114326941"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="531" mass="61256" checksum="F5A736C7B245137C" modified="2025-10-08" version="1">MKDEETTVNPPSNFQNNLIQQGTVSMFHVNLQCISNKVDMINAFLADKKFYDVICFSEHWQTEENLKLINISGFSLANFFCRVEKKQGGVAIYVKENLMYSSLNLNEYNVEQTSEFCAIYIPSMRTNVLTVYRSGNGDCDLFLVNFENVIAFLLNKADKLIILGDFNINFKIKSESSYDIQNLLMSFGLEITINDYTRITSQSSSCIDNIMTNFSENIYRVGVFEPCFSDHRAQFISIDSDLKVVDTNQSLQRSITSSGLQKLKYALASTKMDFFYDTNNDPDVLMFFLTETYNNLILKFFLLKKVRQTAKITPVQWFNDELRSYRSNLSLIKHIADVTKDPDIFKLYKQQKYEYNRQLQNAKKSAYSGFITNSNNKPRDCWKILNFERGNTRSSSVQPDLSPDEINQFFITIAENIITSLPTINNDILFSYRNYPSPSKSFCFRPVVEDEISQIIKSLNNSNCKDVHEINSKILKETYQIVLTPFTHLINLILSTGVFPEALKYSKVHCPGFRVEIAHKSSYVLVKIDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L552</accession>
    <name>A0ABM5L552_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517568.1">
        <property type="nucleotide sequence ID" value="XM_050661611.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517569.1">
        <property type="nucleotide sequence ID" value="XM_050661612.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661611.1">
        <property type="protein sequence ID" value="XP_050517568.1"/>
        <property type="gene ID" value="LOC126892152"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661612.1">
        <property type="protein sequence ID" value="XP_050517569.1"/>
        <property type="gene ID" value="LOC126892152"/>
    </dbReference>
    <dbReference type="GeneID" id="126892152"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="209" mass="24926" checksum="589F1946CF08254F" modified="2025-10-08" version="1">MNKTNSKKPKGKNNDDQRQKDNDDALMSKIENREEQSQDGTIDEDELRKFERELLQRHDQQPKLNRSGAIKHSTLVGEEINTREEEEKEEEEKEEEDPLVKILEAKAFTESHDEKTEEERGGTWEDIEESVLTAFLFDEEDRREMQQMKKRKGDSLEINEKFKKEKLEESKKYPEETDREKVQRKMKQILDILNTEGPIEDERIRMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7M6</accession>
    <name>A0ABM5L7M6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chaoptin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518441.1">
        <property type="nucleotide sequence ID" value="XM_050662484.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662484.1">
        <property type="protein sequence ID" value="XP_050518441.1"/>
        <property type="gene ID" value="LOC114334051"/>
    </dbReference>
    <dbReference type="GeneID" id="114334051"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047433290" description="Chaoptin-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1250" mass="142617" checksum="178E12C484EA6143" modified="2025-10-08" version="1">MLLVLYTILIFFLRCFDCFSSSDCSFNSMCSCSLDEHDSTAKTIHSVSCLSVPFYKFPNLPEGSISQLEVVGTRTTILESESLAGCQVQALILTNNHLQHISDRAFSSLWKSLTSLDLSYNKLDSIPLAALKEIRNLQWINLHGNQISSINGVWSHMKTSVSTLFLGENDITIIPNETTSHNGIKQTQQSLRQFKSLIWLNLDGNRIFEIHKHSLPICLKTASLSYNLLHVFPIELIATSPYLQWLYLRGNHIKLIPQYTLPTMLYLEKIDLAENFISTLPAYLFNNSINIRDINLAFNDFRMLTDNCFSGLNTGRIILSYNSIEKMDYDAFKGILNSLEYLDLDHNNLQRIPEGIRRLHGLKYLYISSNLLKDIDPTAFDNFAPSLRALSLSGNQLVEIPSTALQNCTKLSHFNIAFNEIVEIEEGTFQNWGSTIKSLVLSNNRLIKLSNNIFDGMEELNELSLSFNPLRFIEKDAFAGLTKLESFELSFGFEENELNYEIFDPMVSLKGLSLDHNNIVSIYPSSFLLPELMYLNLESNKIRAIPKTFLKANVHSKLQDIRFSDNELTVIETGTFRALLNLETVLLSNNKIRNIEKQSFSDLPKLNTVILSHNRLSDISRDAFTNLQAIGKIDFYNNLLSEVSFTFFTNISGVLHLNFSRNQIVSCVSDSRVLNIQVFDLRYNNLDKIPVCIEKTSALRKLYLDFNIVNNLDHSVFMHLTSLEYLGLQQNNIKSVKKKAFFGLQNLQSLDLSKNFINQLHIGQFANMSKLRILNLSGNHLSYLPKEIFKSTHIEMLDLSFNLFSVVPSTSLSDIGISLRHFSMRSNNIEHIDITTFPDIPLLQHLDLGNNKLTILPDNVFTSLGLLQTLDLSFNPLRSNFKELFHYAQGLKFLNLANTGMIVTPHFPLPDLIFLNLSYNSIETINKNSVQQLANLKTLDLSHNNLLQVPSQLWMHLPNLKTLELSYNPIKELLFDNFINLQSLQELNIQHLNSLSRFESEAITQLKILSKLSMQTWPKIENFSERLCQMLSNIDQLRVLRILVIETELTDQLLCITNRKIRLLELTGRNLKIVNKDAFARFTKNPELTIKLHGTQIEELPSGLFSNMFKIAHLTLDLRNNMLTHLHPEIFYGNSSRWKNVGTTLISGGLFLSNNPFRCGCHLSWLSHWLRRWTRESLQSHNSPIEAVIKMNEVIKESTCVDSVTGTRIPIVDLEPEDMSCHASALSNGTYSNNASVIFVILLIIIKFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8X3</accession>
    <name>A0ABM5L8X3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518891.1">
        <property type="nucleotide sequence ID" value="XM_050662934.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662934.1">
        <property type="protein sequence ID" value="XP_050518891.1"/>
        <property type="gene ID" value="LOC126892999"/>
    </dbReference>
    <dbReference type="GeneID" id="126892999"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF119">
        <property type="entry name" value="TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045632879" description="TGF-beta family profile domain-containing protein" evidence="7">
        <location>
            <begin position="33"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="8">
        <location>
            <begin position="213"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="348" mass="39875" checksum="DBFC5CA7EEF197B1" modified="2025-10-08" version="1">MGLGCHISARLAACFWTSFYILTLCLLNFSGADPGLFQDLGLKVLPDISKINISINEYTRMMNTYLQMRENSVDDATPVPKLVTFKLDRKVAWRSKVPSVRLRFPVAPNRDAELQSAQLRILTPPQHNDVSSVTVQVNLLLGSRRKRLIEERTFYLSRNSSKWCEADVSSAMRLWLSGEVNLGIELVCLDRKCNLNPLEAGITTLLHTSESRRVRRSIYHKERRTDCHKSRQKRRCCRQNMKVTFSKLEFPEMNFIVEPKVYEAGYCHGLCPPNFNHATNHSRIQSLMHQMEKRNASIRTSRSRIIPKACCAPSKLGSLEILLVDKDDPSKLMVEKWDNMKVIECACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9D8</accession>
    <name>A0ABM5L9D8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519049.1">
        <property type="nucleotide sequence ID" value="XM_050663092.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663092.1">
        <property type="protein sequence ID" value="XP_050519049.1"/>
        <property type="gene ID" value="LOC126893141"/>
    </dbReference>
    <dbReference type="GeneID" id="126893141"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="423"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="58026" checksum="DFFEDA0F6C23D8DD" modified="2025-10-08" version="1">MGLQIDLKRTKIMASIPNNRALVPNLLDVGECNQDKLPTVQTQAGSAEKKACKQETEAGQSSSDMDIDPEVPKSPSSPVCSTNDNLSSYDIGLFRYDGARAVSGEFHGAQAVVRERYPLALYSHCAAHSFNLAVSSACNITAIRNCLGTLESIHTFFIYPKRQNALQDAINEDETLRESRLKKLKKFCKTRWVEQHESVATYLHLQPAVIRALDVISTTWKDPTTSSGAFQLLSAIKTANFQISMHILSSVHSLTLSLSRVLQSENQDLGEAIELADAAKQVLLERRENAEKDFRGIFKTVSEISAKYDIELRKPRLASKQTQRSNVQTDSVQDYFRITIYIPYIDLFLTHIQDRFLNHRKILSNFACLFPNKMKNFNEESCAQLFEPYSSILRDDSRDIWVDEVKLWRQRIAGKNVKNSLEALDVCNGDAFPNVHQMLRILAVLPVTTATNERSFSTLRRLKTYLRSTMSEDRLNGLASLNIHRDVEVDPQRVWEKFFSTPRRVNLLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA02</accession>
    <name>A0ABM5LA02_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519262.1">
        <property type="nucleotide sequence ID" value="XM_050663305.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663305.1">
        <property type="protein sequence ID" value="XP_050519262.1"/>
        <property type="gene ID" value="LOC126893284"/>
    </dbReference>
    <dbReference type="GeneID" id="126893284"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="376" mass="43277" checksum="925397048DF00A3A" modified="2025-10-08" version="1">MNEQLIELVRSQTILYDTNDPNYLKAKLKDELWNDIGKKLNLKSGNEAKTLWLKLRNCHRDALRRQKKCLKSGAAAVVIKKWKFQKQMNFLIPYMSNRSREGNLQEDSEDEDLQQEDSIVDPDSEIFDEVASDIRHDTEEIESVKNDIVDEPSTSGIVIQKNNEKGNAKRKATADQSITTKPAKNNKPKNDDIQEVIKQSIIQRQKRAEERAVERAVQKPLDDDLYHFYMSMYKITKKMSPKFQHRARNDVFQAISQLEAAYLEMQDPSQENYTHREQRVFTGAYVNTHIQQPSYSSTPLPSPSSSHSSQNTENQHYNNPLAPMTNNSFLCSSAYNSRSTNNNYSSTTLTPRLSTETSPQTANTGNIRNFVENYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAM1</accession>
    <name>A0ABM5LAM1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519484.1">
        <property type="nucleotide sequence ID" value="XM_050663527.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663527.1">
        <property type="protein sequence ID" value="XP_050519484.1"/>
        <property type="gene ID" value="LOC114325146"/>
    </dbReference>
    <dbReference type="GeneID" id="114325146"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11813">
        <property type="entry name" value="SH3_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035833">
        <property type="entry name" value="SGSM3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="164"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="534"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="609"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="802" mass="92330" checksum="7FDE6F145A191282" modified="2025-10-08" version="1">MDLAKSLFETRNHEGYVGKEANTKREFEQVIEPDDVDDSIVEGFSQGLTVSDTILPTPGSPFSALTPSMCPQDILAKQTVPDDPNSQPEYRFDEFGFRVDEEDGPEQNSNKLLGIPFVEDPQHRLQWVAHLEFSHNKEVSSLTWDKVDLRLPRTDKLASMVRSGIPHSLRPQMWMRMSGALEKKQKSELSYKDIVKMSSNDSLMMSKQIEKDLLHIMPTNACYSNINSTGIPRLRRMLRGIAWLYPEIGYCQGMGMIAASLILFMEEESSFWIMVTIVEDLLPASYYNTTLIGIQADQRVLRTLISSYLPDTDEVLKNHDIELSLITLHWFLTLFASVVHMKILLRIWDLFFFEGSIVLFQITLSMLKMKEPYLKELENSAQIFNALSDIPGDIDDVDMLLEVSKELTGSLSEVMLETYRRRHLAYLMADQGTLVGNPEAAPNLPKQHLARRQIKKNKSVIQLLLFNENTEDDIKSKNIKQTEILVDLREAILQVARHFLQLDPKLSSEISLVADYSMDSHGQDHVNYINVSKTRKRRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWIGELNGLRGWFPAKFVEMLDERSKQYSSAGDDSISETVTDLVRGTLCPVLKQVLEHGMKRPHFLGGPCHPWLFIEESAMKEVEKDFKSVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINLSHDNAHAQMDVKLRSLICMGLNEQVLHLWLEVLCSSSEIVRKWYHPWSFVYSPGWVQIKCDLRILSQLPFNLNPDWELPVRKETNNQPLKDGVRDMLVKHHLFSWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAZ5</accession>
    <name>A0ABM5LAZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519613.1">
        <property type="nucleotide sequence ID" value="XM_050663656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519614.1">
        <property type="nucleotide sequence ID" value="XM_050663657.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663656.1">
        <property type="protein sequence ID" value="XP_050519613.1"/>
        <property type="gene ID" value="LOC126893450"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663657.1">
        <property type="protein sequence ID" value="XP_050519614.1"/>
        <property type="gene ID" value="LOC126893450"/>
    </dbReference>
    <dbReference type="GeneID" id="126893450"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042378">
        <property type="entry name" value="IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2/IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2_IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028563" evidence="3">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="357" mass="41210" checksum="0BCB0971F3FEEA28" modified="2025-10-08" version="1">MKIEILWLLNLQIIYIYAMNCKEGPQCLMTRSHKMKTADCYNREFREFPQCLTSDVEVIDLGYNRIRKITRSDLSKFSSLKFLYLGDNLISKLDKDLFEDAYRLTTLDLSLNAIVTIPPSIFHLPYLNSLYLKQNLNIDIVQAVEDASPVTSPLIQIDISKTTDIENPTNFPNFGLMPLLTTLNVTGNFYFNVTPGLFMGLCNLQKLINDNVTVAFNDTCDCWRLNYWLETRGIQFTRFICLIAESRAIEEDCTDFQGQTIEHGVLYVPGPAVCTMCVCYHSEPMWCKAIYCDPPYFCKKFRVGERCCEFECLDPPGDTASKMLQAYREKKQKKNSSVQYLSSNAVLIFIYIFSYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LB00</accession>
    <name>A0ABM5LB00_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519621.1">
        <property type="nucleotide sequence ID" value="XM_050663664.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663664.1">
        <property type="protein sequence ID" value="XP_050519621.1"/>
        <property type="gene ID" value="LOC126893453"/>
    </dbReference>
    <dbReference type="GeneID" id="126893453"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29581" checksum="7A00D25346A53943" modified="2025-10-08" version="1">MLNTLLVTAAKKGTTDNLVLVYKTNSFPTYDITKFHNYLNNVVSDVADLFGTIILLHTMYVIGSIVYNTSILIYYVIVVTFSGGDTVFYLTASVLNITLDLGILSVYFLYLISYFFVQVFISGKYYSKVFYFHYLVNTESISILHLIGYLLITIVYCTSTLPLPLFQITTFSIAAASHYLCKESKNTVQICYDIINNSDLNKIINHNLLDQLTFLVQQVVYSSTSLSAAGFFDVNFSMMGFIVSSITSYIIVALQFLNDNSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5Q6</accession>
    <name>A0A6P7F5Q6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gastrula zinc finger protein xLCGF3.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114325051</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128780.1">
        <property type="nucleotide sequence ID" value="XM_028272979.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518869.1">
        <property type="nucleotide sequence ID" value="XM_050662912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5Q6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050662912.1">
        <property type="protein sequence ID" value="XP_050518869.1"/>
        <property type="gene ID" value="LOC114325051"/>
    </dbReference>
    <dbReference type="GeneID" id="114325051"/>
    <dbReference type="KEGG" id="dvv:114325051"/>
    <dbReference type="InParanoid" id="A0A6P7F5Q6"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028128780.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29407" checksum="E07D055447C59402" modified="2020-12-02" version="1">MTDESVCHQPWFAPGAVHKFIFLITLFFRIKNFKCKICNKGFYHAREALEHENLHTGAKTFSCKLCDRSYSLSKRLKDHIKEKHSQTMTEVKIHNCVICFKVYKNRSGLLGHYSSNHKELGYDYSAACDICKKTFPTKHKLMLHERTHTGVKPYECKICNKSFTQKDSLKAHNVVHTGEKPYVCDYCDKRFAHARSHRYHLQTHTGEMSYFCPNCGRGLKSLRGLTIHIKTCRALTCEDDSVVNVNSEPLELAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5T7</accession>
    <name>A0A6P7F5T7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein OZF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114325075</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128805.1">
        <property type="nucleotide sequence ID" value="XM_028273004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5T7"/>
    <dbReference type="FunCoup" id="A0A6P7F5T7">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273004.2">
        <property type="protein sequence ID" value="XP_028128805.1"/>
        <property type="gene ID" value="LOC114325075"/>
    </dbReference>
    <dbReference type="GeneID" id="114325075"/>
    <dbReference type="KEGG" id="dvv:114325075"/>
    <dbReference type="InParanoid" id="A0A6P7F5T7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028128805.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="52515" checksum="47F70843D9A840C6" modified="2020-12-02" version="1">MVTSKTAPHALKVTPSQNQLLMTKKTSPPVLKVISKVLMASNTVGSGPTPPMKVIPTKNLINHPTTLSNVHPSTQVVIQSERVSPIYINPFDYTPYVKNTLSPICRLKIFDAAKGERNLMQEKVFLFAWTCKICRKEFPEKEHLLEHYEMHKNTTDQLGDIDENNDTYTIGSKEVTLNPICMTTYTNIARYQQHVAQKHKPKDHYCDTCKHTFTDDFYLSIHKSTHNQDPGLYECVICKKFQTKNTKTLYEHISKEHVKEEMYCNECDKTFLSRTWFEDHKIFHEDINKRHTYKCRKCESTFTFTSNYSLMEHMQESHIKYKCNQCDVTFPYKQNLDKHNSHLHLTEGKFICNECGEAFTKLSTLRFHEIIHKAGKHVCSVCGKMFKKKVALNLHMRGHTGEKPYSCNFCDKAFAQRNVYYTHRRIHTGERPFSCSECKNSFTDRSALRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6I8</accession>
    <name>A0A6P7F6I8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325252</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_028129060.1">
        <property type="nucleotide sequence ID" value="XM_028273259.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512583.1">
        <property type="nucleotide sequence ID" value="XM_050656626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6I8"/>
    <dbReference type="FunCoup" id="A0A6P7F6I8">
        <property type="interactions" value="2121"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656626.1">
        <property type="protein sequence ID" value="XP_050512583.1"/>
        <property type="gene ID" value="LOC114325252"/>
    </dbReference>
    <dbReference type="GeneID" id="114325252"/>
    <dbReference type="KEGG" id="dvv:114325252"/>
    <dbReference type="InParanoid" id="A0A6P7F6I8"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="122"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="294"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028129060.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="55653" checksum="E575294558241FBC" modified="2020-12-02" version="1">MSEESEKNSLEKVSEVDGSTDGIILNKSAKKRNKNKKKKNENQEENSDQSNEVVQAENNLLSNLSNPINTISIKELKAAMEVFTLSQKPAKSSEEALKKTFQFWNTQPVPKMDEKITVNEAIEPDKEPADIRQEPYSLPDGFMWDTLNLDEPLVLKELYTLLNENYVEDDDCMFRFDYQPEFLKWALQPPGWKREWHCGVRVVKSGRLVGFISAIPATLNIYKKTQRMVEINFLCVHKKLRSKRVAPVLIREITRRVHLNGLFQAVYTAGIVLPKPVSTCTYWHRSLNPKKLIEVKFSHLSRNMTLQRTLKLYKLPDKPKTPGFRKMTAEDIPQAHKLLVEYLSRFDLAPYFNEEEFTHWFLPRTNIIDSFVVENNGEITDFVSYYTLPSTVMHHPVHKNLKAAYSFYNVSKGTSWVPLMTDALISAKQLSFDVYNALDLMENSEFLLQLKFGLGDGKLQYYLYNWKCPSMMPCNIGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6Y2</accession>
    <name>A0A6P7F6Y2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adult-specific cuticular protein ACP-20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326430</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130602.1">
        <property type="nucleotide sequence ID" value="XM_028274801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6Y2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274801.2">
        <property type="protein sequence ID" value="XP_028130602.1"/>
        <property type="gene ID" value="LOC114326430"/>
    </dbReference>
    <dbReference type="GeneID" id="114326430"/>
    <dbReference type="KEGG" id="dvv:114326430"/>
    <dbReference type="InParanoid" id="A0A6P7F6Y2"/>
    <dbReference type="OrthoDB" id="6382835at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028280950" evidence="3">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028130602.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="15326" checksum="EE9FF4F80E482062" modified="2020-12-02" version="1">MQIFIVYVAAIAAVAYARPGGDYGHLELAGGYEDGGHYGGHEATSYQHGGLIANEIGHGDEGHHEEHVDYHAPAKYHYDYAVHDLHTHDIKSQWETRNGDKVKGEYTVVEPDGSRRIVSYTADKHTGFHAVVKNVHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FA89</accession>
    <name>A0A6P7FA89_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327941</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132466.1">
        <property type="nucleotide sequence ID" value="XM_028276665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FA89"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276665.2">
        <property type="protein sequence ID" value="XP_028132466.1"/>
        <property type="gene ID" value="LOC114327941"/>
    </dbReference>
    <dbReference type="GeneID" id="114327941"/>
    <dbReference type="KEGG" id="dvv:114327941"/>
    <dbReference type="InParanoid" id="A0A6P7FA89"/>
    <dbReference type="OrthoDB" id="6780283at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132466.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53725" checksum="C1BDADC317C42023" modified="2020-12-02" version="1">MVRKRSKVAKRHYYSEEEPETESDFEDDPEYEPAPKKYSLRQRKRQTFNADDWEYEEDVPVETPKVASDDEEFNVTNNNPKSDEAANSEQVSDSTDKPTESPAEETVEKCDELVDFEDMIRADVVVNKNRIDYDNVIQKTEIKVQPLSETEQVIKKSKIQPPKSQPAKSQPAKPGKKRGRKPKRRKSEEEPQYFAPQIQEDENDADYHPYKPRRTRRPKKRPAGEIDSSLLEDFDNDDDLEDTNDRDYNPEDDLDYPGLSNFILNRQITDDFEDTTSNTVVSKEGSLPEAYSSVDTTTADTTDSVANIDLVSGSSDLGNTQSGAASEVIENESQIEKATNTPDSEKDASETVAVSVSAADTTSAVQVPDTTDKEKPFDLIAANNGSCSREESNDAPLQLDEINESDKNNSLQNVSSTSSDSVIKVNENCVSTDLQVNGSVKHVEDLVVEADSVIDDDEDDDDVVFVEQEKKYEIIVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFQ2</accession>
    <name>A0A6P7FFQ2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SET domain-containing protein SmydA-8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114327594</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132063.1">
        <property type="nucleotide sequence ID" value="XM_028276262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFQ2"/>
    <dbReference type="FunCoup" id="A0A6P7FFQ2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276262.1">
        <property type="protein sequence ID" value="XP_028132063.1"/>
        <property type="gene ID" value="LOC114327594"/>
    </dbReference>
    <dbReference type="GeneID" id="114327594"/>
    <dbReference type="KEGG" id="dvv:114327594"/>
    <dbReference type="InParanoid" id="A0A6P7FFQ2"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF4">
        <property type="entry name" value="GH11294P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="44"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028132063.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="60792" checksum="B82BC5434CAE26BD" modified="2020-12-02" version="1">MSEENKCQLCQKPADQRCGGCHSVHYCCKEHQKNDWKQHKKHCKPFKVCTDDVLGRHLKATKDLKPGDVIIQENPLIWGPAISTVPVCLGCGQEVNERNSRPCSKCGWPMCSDLCEKAPAHIPECRYTFLRGDKVSIKNFGITHPNYQCITVLRILYQKQFLPDVWKKIEVLQSHDKERKGTQSYEHERTQIAQFILKFFKLAGTFTEEEIMEVCGIIMVNSHEVPLTEPNHIAIYEQASMLEHSCSANCSKSFSNKGGLVITAGTHIKRGDHLSICYTDPLWGTPNRRHHLYNSKFFWCSCDRCKDPEEFGTYFSALRCQDSNCKGYVIPKTFIDNSTNDKGSDWYCTACPSKLSSYSVQDLLERIGKDLNDMPKQNIKECRSFIETYEELLHPNHFLLTDVKLALLNLIGQTKEDMREISDDELQLKFRLGQSLLNLFKQLVPGEKRVRGVCLFELIAALAEIARRKTDPNIVYASMLECKSLLTQCIELLKHEPDALPEGKMCQQARNNLKELELVLQTLHKTLGDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGM2</accession>
    <name>A0A6P7FGM2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114327824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327824</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132333.1">
        <property type="nucleotide sequence ID" value="XM_028276532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGM2"/>
    <dbReference type="FunCoup" id="A0A6P7FGM2">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276532.2">
        <property type="protein sequence ID" value="XP_028132333.1"/>
        <property type="gene ID" value="LOC114327824"/>
    </dbReference>
    <dbReference type="GeneID" id="114327824"/>
    <dbReference type="KEGG" id="dvv:114327824"/>
    <dbReference type="InParanoid" id="A0A6P7FGM2"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028086182" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132333.1"/>
        </source>
    </evidence>
    <sequence length="91" mass="10100" checksum="C036E723D4575961" modified="2020-12-02" version="1">MKNFVALIILSCLSVIVLSQTTNRLCPDNSTPGCKPCCPDPSCLFRKPICPFEKVCKNLLPNLCLFECRCNPGYLKNIVGHCVLPDKCLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGQ8</accession>
    <name>A0A6P7FGQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327851</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132368.1">
        <property type="nucleotide sequence ID" value="XM_028276567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGQ8"/>
    <dbReference type="FunCoup" id="A0A6P7FGQ8">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276567.2">
        <property type="protein sequence ID" value="XP_028132368.1"/>
        <property type="gene ID" value="LOC114327851"/>
    </dbReference>
    <dbReference type="GeneID" id="114327851"/>
    <dbReference type="KEGG" id="dvv:114327851"/>
    <dbReference type="CTD" id="990"/>
    <dbReference type="InParanoid" id="A0A6P7FGQ8"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000265">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="188"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="10">
        <location>
            <begin position="454"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028132368.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="62004" checksum="4002B83FDDE068A8" modified="2020-12-02" version="1">MNTRSSARLCSKNRGQSFRDLQKFSKYSSDSSSDDDSDLYYESISTPRKTKSKAKYEDSGTPPKQKKIEARTPNNKSTVRSTTNTPSLQRLAITSPKKPKSTRKTLFKENDTTKKTTENKKIERILTNSDSECTSDDEESSTDIPKNRNAYQSARQALHGTAPTEMPGREKELKDLREFIDRHIKDQISGSLYVSGPPGTGKTASLNIILKEKKLMSGVSHVYVNCTAIKSPTAIYSRICKELNIKVDGKSEKEHLLQIVKYLKKKHKTILLVLDEIDQLESKNQSILYTIFEWPSKPNAHILLIGIANALDLTDRILPRLQARCELKPTLMHFAPYTKPQIIEIFTSRLRAANVLDIFSPAAVQMLAGKVAAVSGDIRRALDIGRRVVELAERSKKTGALKSVENLANQLVDEETKTVDLKQVLTVLNSVYGTSQNLDDNTEDSFPLQQKIIICSLLLMLKKNKSKDVTIGKLHEVYCRVCKKRKIGSVDQTELVGLCALIESKGIITVSGKKEPRLNKVSMVWDQDEVTNALKDKQLISDILKDESCLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH56</accession>
    <name>A0A6P7FH56_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114329378</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134257.1">
        <property type="nucleotide sequence ID" value="XM_028278456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH56"/>
    <dbReference type="FunCoup" id="A0A6P7FH56">
        <property type="interactions" value="1286"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278456.2">
        <property type="protein sequence ID" value="XP_028134257.1"/>
        <property type="gene ID" value="LOC114329378"/>
    </dbReference>
    <dbReference type="GeneID" id="114329378"/>
    <dbReference type="KEGG" id="dvv:114329378"/>
    <dbReference type="InParanoid" id="A0A6P7FH56"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="64"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028134257.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25139" checksum="EF1F3BFD6EED87E7" modified="2020-12-02" version="1">MFITRPCSTGIGIPGIGVTLLLAPLLVIVAIVKASAKLEEQFCSSDSLDGCSQSTNTMSSPDNYKNANSIYEFTANDIKGEPVSLEKYRGHVCIIVNVASQCGYTKNNYAELVELYDEYAESKGLRILAFPCNQFAGQEPGSNAEICQFMQNKNVKFDMFEKVNVNGNDAHPLWSYLKHKQGGVLGDFIKWNFTKFIIDKNGQPVERHGPNTNPKDMVKYLEKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHH2</accession>
    <name>A0A6P7FHH2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114330201</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135326.1">
        <property type="nucleotide sequence ID" value="XM_028279525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHH2"/>
    <dbReference type="FunCoup" id="A0A6P7FHH2">
        <property type="interactions" value="2089"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279525.2">
        <property type="protein sequence ID" value="XP_028135326.1"/>
        <property type="gene ID" value="LOC114330201"/>
    </dbReference>
    <dbReference type="GeneID" id="114330201"/>
    <dbReference type="KEGG" id="dvv:114330201"/>
    <dbReference type="CTD" id="40781"/>
    <dbReference type="InParanoid" id="A0A6P7FHH2"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028135326.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13411" checksum="3F8366EEE8795AC3" modified="2020-12-02" version="1">MALTKPKSEMSSEELQAREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTELPRAGKGRKKAKPVNKDRFISKMFLRGDAVILIVRNPLATVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI79</accession>
    <name>A0A6P7FI79_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain family 10 member A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114330474</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135621.1">
        <property type="nucleotide sequence ID" value="XM_028279820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI79"/>
    <dbReference type="FunCoup" id="A0A6P7FI79">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279820.2">
        <property type="protein sequence ID" value="XP_028135621.1"/>
        <property type="gene ID" value="LOC114330474"/>
    </dbReference>
    <dbReference type="GeneID" id="114330474"/>
    <dbReference type="KEGG" id="dvv:114330474"/>
    <dbReference type="InParanoid" id="A0A6P7FI79"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF465">
        <property type="entry name" value="AT17652P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028459685" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="44"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028135621.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21289" checksum="A345294B009F136C" modified="2020-12-02" version="1">MRKQLLGVLLTILFSVEINAQSYVITNDTGIAQSIAPSIPVERNGNTLYYFGYTYTGSWLGAMEHCKSLNMDLASIESQEENDFLYNRMKPFLGGGVEYWFWTSGTTLSSGRWIWMRTGRPIGWANWGEGYVGLGRCLEVRYNYASGLKWHDTLQNEGRHALCEAKITRTVADLIPKFCNRWDYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJH7</accession>
    <name>A0A6P7FJH7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114328500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114328500</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133168.1">
        <property type="nucleotide sequence ID" value="XM_028277367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277367.2">
        <property type="protein sequence ID" value="XP_028133168.1"/>
        <property type="gene ID" value="LOC114328500"/>
    </dbReference>
    <dbReference type="GeneID" id="114328500"/>
    <dbReference type="KEGG" id="dvv:114328500"/>
    <dbReference type="InParanoid" id="A0A6P7FJH7"/>
    <dbReference type="OrthoDB" id="6783999at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028325424" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133168.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15890" checksum="E4F9B2A194CDF93D" modified="2020-12-02" version="1">MKVALLLLVFICFVNRIYSRPNIFKFKDAKRIHAVCQANSETHVNEYLERLQEFGKIEVPNMAKHTLCMNINAGLQYENGDIAVERLRSDLEEVSNNENKIKEIVDTCGVRAPGSPEDAAMAFGKCLCSQWPQHAVCVCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FS78</accession>
    <name>A0A6P7FS78_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC114333470 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114333470</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139156.1">
        <property type="nucleotide sequence ID" value="XM_028283355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FS78"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283355.2">
        <property type="protein sequence ID" value="XP_028139156.1"/>
        <property type="gene ID" value="LOC114333470"/>
    </dbReference>
    <dbReference type="GeneID" id="114333470"/>
    <dbReference type="KEGG" id="dvv:114333470"/>
    <dbReference type="InParanoid" id="A0A6P7FS78"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028139156.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42577" checksum="0CE97E9E58B07C69" modified="2020-12-02" version="1">MTSTQPSTSHSYCSVPQCSTYYNSKIPISFHRFPLDENMRKVWQGVLQIGKPISNYMTVCSLHFTEKDYFPITPETKLKRLKKNAVPSAKLPQRSHEVISRKHKAPTERIDTELNNPLIETSCSVPGCNNKSTGSECTEFFPLPENETTRQAWLKLCWLTAENLDRSKVAICSNHFDDNAYLTEINDVGALIYIVKILDPDALPTLNLPTAAILQLPPIIEIISIEYSKPQQEKEKNETIKNLQLWQESNDAIQKKIDLVEADIQQKKKQLKEHDNTLVKLRSQDSEGLSDKTLSNVFSKAQLKLLFGNTRAVWSDNDFAVGYSIMQLSNARFYKYLTKVLNYPFPGRSTIQSFVKTKNRMLKRQIVVKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSH7</accession>
    <name>A0A6P7FSH7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114330563 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114330563</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135745.1">
        <property type="nucleotide sequence ID" value="XM_028279944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279944.2">
        <property type="protein sequence ID" value="XP_028135745.1"/>
        <property type="gene ID" value="LOC114330563"/>
    </dbReference>
    <dbReference type="GeneID" id="114330563"/>
    <dbReference type="KEGG" id="dvv:114330563"/>
    <dbReference type="InParanoid" id="A0A6P7FSH7"/>
    <dbReference type="OrthoDB" id="6713042at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028135745.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="14166" checksum="52EAC12C2CF32846" modified="2020-12-02" version="1">MTKVYHQIISIKLRRMSSLWTTNCLVFVICMFVISKSLSQDDSQAERKDPEYCNDLCSSVEVLCEPTNCTNKQVEGYKPELCRCCTECYTRLDEGDKCGDNDEAICDQGLTCRNNVCRKEAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWH7</accession>
    <name>A0A6P7FWH7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Leucine-rich repeat-containing protein 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114331569</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136975.1">
        <property type="nucleotide sequence ID" value="XM_028281174.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136976.1">
        <property type="nucleotide sequence ID" value="XM_028281175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWH7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281174.2">
        <property type="protein sequence ID" value="XP_028136975.1"/>
        <property type="gene ID" value="LOC114331569"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281175.2">
        <property type="protein sequence ID" value="XP_028136976.1"/>
        <property type="gene ID" value="LOC114331569"/>
    </dbReference>
    <dbReference type="GeneID" id="114331569"/>
    <dbReference type="KEGG" id="dvv:114331569"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028136975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028136976.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40674" checksum="B3336E3B27FBB8D4" modified="2020-12-02" version="1">MENYTSDSSDSENSVKVIDYAYLLLNPDETEDKLEKYFDEKKSFELVEKLILHHNQLITLPDSVYQFSNTRVLDISNNGITTLPDVFKYLPLTSFTAKNNLLTCSSIPKSFEKCLSLIELNLSGNKLCHFPEQILDFVGLKFLYLGGNGMVEISKNIWKLQNLQMVSFGGNKLTEVPAAIGLLQHLQALVLCDNHIECLPANIANLHKLKTLLLHKNKLRTLPPEIVALKNLSELSLRDNPLIIRFVSEMSHSPSSLLELSARTIKLYNIGYGPGDIPATLFSYINSGHHCVNPHCKGVYFDNRVEHIKFVDFCGKYRIPLLQYLCSSKCANTASVREWKDESIDRPSRSYMMKKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXH6</accession>
    <name>A0A6P7FXH6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114333730</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139517.1">
        <property type="nucleotide sequence ID" value="XM_028283716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXH6"/>
    <dbReference type="FunCoup" id="A0A6P7FXH6">
        <property type="interactions" value="2485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283716.2">
        <property type="protein sequence ID" value="XP_028139517.1"/>
        <property type="gene ID" value="LOC114333730"/>
    </dbReference>
    <dbReference type="GeneID" id="114333730"/>
    <dbReference type="KEGG" id="dvv:114333730"/>
    <dbReference type="InParanoid" id="A0A6P7FXH6"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000010">
        <property type="entry name" value="Mitochondrial-processing peptidase alpha subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000014">
        <property type="entry name" value="Mitochondrial-processing peptidase alpha subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="91"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="246"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028139517.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60374" checksum="47927DD090EB3D30" modified="2020-12-02" version="1">MALQTGYKLTRALLPKNQHQLWNASKTVEYCLAKQYTSTDRTDLTGGAKSKVTDMPPMSEAVKGLPQAVYANFKEEDQKTKVTILSNGLTVASENRFGAFCTVGVVIDSGSRYEVAYPSGISHFLEKLAFNSTKFYPDKDEMINKLEKHGGICDSQASRDTFIYAASAYTSGLNDVIQLLAEATLRPNITSEELLNAKQAINFELETLNMRPEQETILMDMIHAAAYNDNTLGLPKLCPYENVNTINRNVILTYLKNHYTPKRIVVAGVGVEHSKLVDAVQKFFVDIKPIWTESNSEVIKDVSVDLSVSQYTGGIVHEECEIPQFASAGLPVLSHVVVGLESCSHQDKDFIATCVLNIMMGGGGSFSAGGPGKGMYTRLYTNVLNRYHWMYSATACNHAYSDSGLFCIHASAPPTHVRDMVEVIVKELVNMPKNITDEELRRAKTQLQSMLLMNLESRPVMFEDIGRQVLASGQRRRPKYFINEIEKISKDDIVRVAKRLLSSQPAVAARGDLRKMPSLEYIQAGLIDSEGRMPNGRKLSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYE8</accession>
    <name>A0A6P7FYE8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Crustapain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335563</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141609.1">
        <property type="nucleotide sequence ID" value="XM_028285808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYE8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285808.1">
        <property type="protein sequence ID" value="XP_028141609.1"/>
        <property type="gene ID" value="LOC114335563"/>
    </dbReference>
    <dbReference type="GeneID" id="114335563"/>
    <dbReference type="InParanoid" id="A0A6P7FYE8"/>
    <dbReference type="OrthoDB" id="10328791at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028170547" evidence="2">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028141609.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38751" checksum="05C4F2F90BA52452" modified="2020-12-02" version="1">MKIILVVLLIVVATTASTDEEKWTKFKITHNRVYKNIEEHDHRFEIFKKNLIRIKEQKEKYEKGESTFNFGITQFADLTEEEFLGRFKSSGSSKLSEIVSNVSSSKSRSKISSASDDLPDQYDWVQSGAVTPVRYYGDCGACTAASVVAAVEGAEFIKTGNLIQRSTRQLRDCIPFDPHECWICYEKVLNYTRDFGIMTEKDYPWKYEFEDCQTDNITATDPLIQIIDWIYVAEGEEEELQRTVYLEGPVAVSLDATNYFQLYTDGVLDDPSCGNTMDDLDTTLLLVGYGESERLGQYWILKYYFGPYWGKDGYLWLRRNKNNQCGVATSAVIPVLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYI7</accession>
    <name>A0A6P7FYI7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epoxide hydrolase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114335597</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141649.1">
        <property type="nucleotide sequence ID" value="XM_028285848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYI7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285848.2">
        <property type="protein sequence ID" value="XP_028141649.1"/>
        <property type="gene ID" value="LOC114335597"/>
    </dbReference>
    <dbReference type="GeneID" id="114335597"/>
    <dbReference type="KEGG" id="dvv:114335597"/>
    <dbReference type="InParanoid" id="A0A6P7FYI7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="85"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028141649.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46011" checksum="68C1FBDAD606A961" modified="2020-12-02" version="1">MATMCIQSISVVDSIRIHVLSIIFGVWVICKRLLKWIWDPKRLNSHQLRDSPPSCLLDSSLGQHKYVKLKGIKLHYVEAGQRDQPLILLLHGFPDCWLSWRYQLPALSQHFRVVALDLKGFGDSDKPAWRSSYRIQIILEEIKDFIHALGVSECDLIGHDLGGLIGWYLVHQHPGLVKKFIAVSCPHPNVYWKNLISASKVAYQWLNFVQIPYLPEIDALKEDVKIINQYHKHLPQNDIYLEAYKYVFSRQEDWTGPINYYRNLPFLKVQENGAEITNTVVLITGAKDHLVKLEGIVDSTEYCEKFFMKIIQNAGHFPHQENPSSFNRTILKYLVDKSELKIDKDLEGSRKNLMKGILGAVTNTVKYGNSVFDSVHKRTTNVVSSIPTMGLSLNYMHSNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZB9</accession>
    <name>A0A6P7FZB9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC114335797</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028141886.1">
        <property type="nucleotide sequence ID" value="XM_028286085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141887.1">
        <property type="nucleotide sequence ID" value="XM_028286086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141888.1">
        <property type="nucleotide sequence ID" value="XM_028286087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286085.2">
        <property type="protein sequence ID" value="XP_028141886.1"/>
        <property type="gene ID" value="LOC114335797"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286086.2">
        <property type="protein sequence ID" value="XP_028141887.1"/>
        <property type="gene ID" value="LOC114335797"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286087.2">
        <property type="protein sequence ID" value="XP_028141888.1"/>
        <property type="gene ID" value="LOC114335797"/>
    </dbReference>
    <dbReference type="GeneID" id="114335797"/>
    <dbReference type="KEGG" id="dvv:114335797"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF61">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028141886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028141887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028141888.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56640" checksum="05127D5981FB2743" modified="2020-12-02" version="1">MVVTEIPDRIADTFHGRTIFITGVTGFIGKALLEKLLRNTNVKKIYVLIRTKKGKTPQERLEDIFKNILYSKLLSQNPDAPKKCIAISGDVSEVDLGISGSDRQLIVKEADFIFHSAATTRFDDTIKYAVTVNTRGTKYMLDLAEQCTKLKLFIHVSSSYAFPNNKVTMEKEYKTKASPHEVLSSLNWMDEDGINDKKILGDIPNSYTFSKALAENLVYEKVGKIPLIICRPAVVIPSFQDPIPGWANNLQGPMGLFVGAGKGVIRCMYMDSKSYANLIPVDAAVAGILVFSWYYLNVKGAPYIFNICVPETEFKENWETILKSAQEVIETDVPFNGILWYPGGTMTKSKTYAKINFFLFQLIPAIFIDLILFCLGYKPILYNIQMRINKGTEMFEFYTTRAWDFETKTIFAIREALNERELKTYFVKADNINLKKYFIEALLATRRNILKETDDMIPAAKRNMKIMFVLDRFVKIAFFVILGYFLYKWSFSLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZV0</accession>
    <name>A0A6P7FZV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114332711</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028138338.1">
        <property type="nucleotide sequence ID" value="XM_028282537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZV0"/>
    <dbReference type="FunCoup" id="A0A6P7FZV0">
        <property type="interactions" value="1064"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282537.2">
        <property type="protein sequence ID" value="XP_028138338.1"/>
        <property type="gene ID" value="LOC114332711"/>
    </dbReference>
    <dbReference type="GeneID" id="114332711"/>
    <dbReference type="KEGG" id="dvv:114332711"/>
    <dbReference type="CTD" id="32195"/>
    <dbReference type="InParanoid" id="A0A6P7FZV0"/>
    <dbReference type="OrthoDB" id="6339763at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03742">
        <property type="entry name" value="SOCS_Rab40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000371">
        <property type="entry name" value="RAB40C, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="18">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028138338.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="32023" checksum="450A916C6F2B683E" modified="2020-12-02" version="1">MTEDISKPPKQYDYLLKFLLVGDSDVGKQEILSDLDDGSSESPFCGYSGKSYKTTTILLDGKRVKLQLWDTSGQGRFCTIIRSYSRGAQGVLLVYDITNRWSFDGLDRWLKEVDEHAPGVPKVLVGNRLHLAFNRKVGQRDAQIYANKHSMAFFEVSPLCNFNIHESFCELSRMALHRNGMERLWRSNKVLSLQELCCRAIVARTTVYSIEQLPLPTSVKSHLKSYALTSSSTQWRYVISQKKNSRGSRSRKKRFTSTPTTPGSVTDKDSITSCVPRNSCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0B5</accession>
    <name>A0A6P7G0B5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ras-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114332514</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138120.1">
        <property type="nucleotide sequence ID" value="XM_028282319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0B5"/>
    <dbReference type="FunCoup" id="A0A6P7G0B5">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643676.1">
        <property type="protein sequence ID" value="XP_050499633.1"/>
        <property type="gene ID" value="LOC126880045"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G0B5"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04145">
        <property type="entry name" value="M_R_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028138120.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23609" checksum="59011A794FE60A35" modified="2020-12-02" version="1">MSKINDRDRVPNYQTYKLVIVGGGGVGKSAITLQFIQSYFAADYDPTIEDSYTKQCVIDDIPAKLDILDTAGQEEFSAMREQYMRSGEGFLLVFSVTERSSFDEIYKFHRQILRVKDRDEFPMLMVGNKVDLEHQRVVWQEEAQQLARQLKIPYIECSAKMRMNVDNAFYELVRVVRKFQLSERPPLKPNYIKRNKKNCCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G598</accession>
    <name>A0A6P7G598_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337875</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144229.1">
        <property type="nucleotide sequence ID" value="XM_028288428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G598"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654487.1">
        <property type="protein sequence ID" value="XP_050510444.1"/>
        <property type="gene ID" value="LOC126887131"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G598"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028144229.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58054" checksum="88EB56B39E555D9B" modified="2020-12-02" version="1">METEEKQNEASGLLQTVQNGKEKETATPTEVEAEQEDIIQKCIGVLGRWHIWLCFIIFLVKFGVSWHQLSIVFLAPPIKYYCINNATETCLSNCTHYLYDTSIFTNTISMEWDLVCSKSYLVSLTQTLTMLGILVGNMLFGYLSDKFGRKLPLVLAVALQGLSGLGAAFSPWFTLFIILKFLSAVATGGTMITSFVLIMEIIGTEWRTVLGILYQIPFNLGHLLMPLFSYYLRNWRHFQIMISVPSLFLISYYWILPESPRWQLAVGKEKQAIETLKKAARRNKLPTEKIEHDVNLYLEHKHLNQKEVHQGNILDLVRTPIMRVYTIAVGFNWFVCGLCFFGVSQFIGQLGGNIFVNVAISAVIQVPSTIFACYATKAWGRKKSLLIANIVSGLSIFIMGFVPSNLPWLRTLLSSIGMFGLALSFPTVYIYSGELFPTVVRNIGVGTSSMCARIGSMIAPFVATLGNVEPWIPPVIFGIVPLIGAILCLKLPETLDCKLPDTIEEAEALNSSKPKPSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6S5</accession>
    <name>A0A6P7G6S5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-binding protein Staufen homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114334387</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140225.1">
        <property type="nucleotide sequence ID" value="XM_028284424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6S5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284424.2">
        <property type="protein sequence ID" value="XP_028140225.1"/>
        <property type="gene ID" value="LOC114334387"/>
    </dbReference>
    <dbReference type="GeneID" id="114334387"/>
    <dbReference type="KEGG" id="dvv:114334387"/>
    <dbReference type="InParanoid" id="A0A6P7G6S5"/>
    <dbReference type="OrthoDB" id="5961559at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028140225.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39238" checksum="76AA8758391D3DD4" modified="2020-12-02" version="1">MLYNLCIISYPPSSPSFIHTHHFILSVRLTKGKVNNKMGKMANNRKTPVMALQELAVKKGFPVPQYEIVDSILGTHNDRFDCRVKACGMEAEGTGTSKQISKHEAAYKLLKLLEEGGIYDPKELPVQEFQVEVAGLENGSSVEAPVNWIGPLIEMCAKTKIEDPMFKEISAVGLSHSREFTYECRIGSLKTLAVGRTIKMAKHLAAKEMLEKLKDNDILSILILENPKKDHQQRYNKLMTSVVRNKMAKLKDFITVFHDLMEKYEKNSDVFINDLRERTEESLVRILKQLKLKHDILVVKDESPVIIVLHVNCNVPYAVMGMGATVEQAKEEALDETFLLLDGLIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G829</accession>
    <name>A0A6P7G829_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114338798</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145214.1">
        <property type="nucleotide sequence ID" value="XM_028289413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G829"/>
    <dbReference type="FunCoup" id="A0A6P7G829">
        <property type="interactions" value="2706"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289413.1">
        <property type="protein sequence ID" value="XP_028145214.1"/>
        <property type="gene ID" value="LOC114338798"/>
    </dbReference>
    <dbReference type="GeneID" id="114338798"/>
    <dbReference type="KEGG" id="dvv:114338798"/>
    <dbReference type="InParanoid" id="A0A6P7G829"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000375">
        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000229">
        <property type="entry name" value="Small nuclear ribonucleoprotein U5 subunit 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028145214.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39144" checksum="D7E5ADB8DB5537CA" modified="2020-12-02" version="1">MVIENKRRADDAALVPVSKKQRNEIVQRNKNTSVLQATAPRTSNLFAPIMQLEGHEGEIFSVDFHPEGQYLASTGFDRKIFLWAVYGECENISVMTGHTGAVTEMHFNTDGSQIFTSSTDHTLGLWDVATSQRIKKYKGHTTFVNCVQGARRGPQLMCSGGDDNTVKLWDTRKKQNVGSINTPYQNTAVSFSDTTEEIFSGGIDNEIRVWDMRTYELLYCLRGHTDTITGLSLSADGSYLLSNSMDNSLRIWDVRPYAPVERCLKIFNGHQHNFEKNLLRCAWSPDGSKITCGSADRFVYIWDTTSRRIIYKLPGHNGSVNDVKFHPNEPIILSGSSDKQLYLGEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD46</accession>
    <name>A0A6P7GD46_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114340782</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147354.1">
        <property type="nucleotide sequence ID" value="XM_028291553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GD46"/>
    <dbReference type="FunCoup" id="A0A6P7GD46">
        <property type="interactions" value="1485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651087.1">
        <property type="protein sequence ID" value="XP_050507044.1"/>
        <property type="gene ID" value="LOC126884828"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GD46"/>
    <dbReference type="OrthoDB" id="10062454at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="70"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028147354.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="69297" checksum="240E5BAEEB7C8979" modified="2020-12-02" version="1">MTILENNVIPMHNKLSLTKTKYKTGDQLKRKYLFEEDSIPNKKPALNDMLNGYRGDQRSNGDAVQESPVATLSNMGNTCFLNSVLYTLRFAPTFLHNLHHLIGDLSLVSSKLNQNKAKTSSLGRNIGSITGPSSRSTSSKDLLSLGSSNDIIPKSKVQVVTEKLHELFLTMHNLEIKDLVDPYQPVALLQAVREANSIFEGNNQQDAHELLVYLLDNIRETCDVLTQQVQQNPELLNETESLPTVNSSKLWNVRNSWKKSLKKKDKSTKEAISEEQVNGAHTTDAEDSTSIDSNNGSTKKKLGYNFVAEDFEGITLRRTKCLECESVTERKEPFYDIPVPISLKDDDLADMNVNDIFRRACVTTEKLCDSNKYLCEKCERYNEASREVLFEKLPNIMVLQLKRFTTSTSGVQKVITYLPTPLALECFCESCCKVEDNQSRIHRYKLCCVIMHLGGTMASGHYIAYVKASDHLEDYTDCTRDLPKGSLSASSSEKSLNIIKFLKPRTLGSSLIEGKNGLSSRSVNAMRTCKSMDCCGVKVNKNVVENVINSSSRKIGQDYKWHHSNSSSDDMWLECDDENVRAISSQEFVEELAYKPNSTSTPYLLFYAKITDQHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GE03</accession>
    <name>A0A6P7GE03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341144</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028147726.1">
        <property type="nucleotide sequence ID" value="XM_028291925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GE03"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291925.2">
        <property type="protein sequence ID" value="XP_028147726.1"/>
        <property type="gene ID" value="LOC114341144"/>
    </dbReference>
    <dbReference type="GeneID" id="114341144"/>
    <dbReference type="KEGG" id="dvv:114341144"/>
    <dbReference type="InParanoid" id="A0A6P7GE03"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028147726.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="23319" checksum="B46DCD749960B19F" modified="2020-12-02" version="1">MKNKEYQEIAKLFKDKNKKLFQIHKIEKIHNPYLLGQYAIKKKHLEKLSKKNKRKIPKDIRLFHGTGKDEMESICKTNFDWRRAGINSGHKFGQGVSFSATANYATNYTDDKDELKVIIVAKALIGNTCIGYDKMIIPEENCDTSSDKNENVFVKYDDGTFYPEYRIYYMGNNPDKLNYYQQRKKSITLRDFILDKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEJ6</accession>
    <name>A0A6P7GEJ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase II-associated protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337173</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143373.1">
        <property type="nucleotide sequence ID" value="XM_028287572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEJ6"/>
    <dbReference type="FunCoup" id="A0A6P7GEJ6">
        <property type="interactions" value="1442"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287572.2">
        <property type="protein sequence ID" value="XP_028143373.1"/>
        <property type="gene ID" value="LOC114337173"/>
    </dbReference>
    <dbReference type="GeneID" id="114337173"/>
    <dbReference type="KEGG" id="dvv:114337173"/>
    <dbReference type="InParanoid" id="A0A6P7GEJ6"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="6">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="5">
        <location>
            <begin position="292"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="7">
        <location>
            <begin position="934"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028143373.1"/>
        </source>
    </evidence>
    <sequence length="1148" mass="132391" checksum="A8A326F4FFE531B7" modified="2020-12-02" version="1">MYARPKPGETEEDLLKLQEEFERNKAENKIQLAATVVSNKKSEDKSLVESSKAEVSEIDIKEQLANTFEAIPNDTQLKNVVEHKNQPSPSIFKFNRDRGFPQAKRREETAVAGRGSIFKQQMKKQKKEETAMEVDNTPITVSNLVIKERNEISARSSCNENRHKPENLPTQSYLLTGKDSGQIHEENLNLLKNMSEEEIVEEREKLLSMMDPAIVQYLKSRRKQVPVETRNLPISEQNKAADDFNFEEIETTSEILNQPAAEKWLNFDIIETNKLAWMKNIDIPKLKAEKFEARFDSGGWILPYSQSEITEKDRILYHHGEEPGRPGYTLQELIQLSRSSVIQQQIFALNTIANIMSLYSTGVYDEIIDLPLEQIFFSTRYSMDENTVPVLNASIKVMRNLIYSHVDETCLDSLLGFGLGFIQPILAIDSDMEDDTTVNDQQLVEKDIILCLVRTNILIRIRYIINTVRPSLETITYCLEILIRLARGSDFIVNRIIDCDNLIESIVTHCLPLVMITNTPTSGNGFPLFQAVKLIRIISSRSKTLALEMINKHKVLDSILMYLSNDLFSSDITGIRLQTECIHFWSVLVHYGLAMDYFRPLQPVLLSLLDYHFKNSNLEMKTTYIRLGHISAVLILLTNIIKQNFPLILPFMPIINRCVPKWTTQLCNLTEYTCGKLQLIASLICCMTALRQYQQIDEFDNRILQILNSQGFRMVTDKIQSGSMLLNNYDTHKPSNNLRTLEVASWHTMDHVVPLIQSNSCIPFLHAVSMYVNCTDNQKVKISFLTHPNIQKYLVSLSKLDKYYLTNHWFARPESIFLMNILKSAVAIKDDIDTSIFYKVAVKCLCVFNSEQKPEIRFILANIIFCSKFYPSEVLMENLDISQRSLSLEVSLKNLNEILKVYTQILGLQNNVPDFSTSCSLDINIGNVIPIDWIYTPILVLYTNQQQNNNKTDENEQVFIIRNCLRWILIYETYFPFLASRINPTDKFCRLACVFLGSDSLFLIKEIHDLLELCFKNVMKREKDFIFNKKIQGLSNFQDFYAQLLEQYQGVSYGDILFGNIIIVPLAQKHSIEYRKTLWSEYMGVVQVCNVTPDQYIGDIQLFLDPPEIQESLLKCYRRAIIGKMARPHSILYKIANHHVETFIKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF71</accession>
    <name>A0A6P7GF71_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114338508</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028144907.1">
        <property type="nucleotide sequence ID" value="XM_028289106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF71"/>
    <dbReference type="EnsemblMetazoa" id="XM_050643537.1">
        <property type="protein sequence ID" value="XP_050499494.1"/>
        <property type="gene ID" value="LOC126880017"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643538.1">
        <property type="protein sequence ID" value="XP_050499495.1"/>
        <property type="gene ID" value="LOC126880017"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643539.1">
        <property type="protein sequence ID" value="XP_050499496.1"/>
        <property type="gene ID" value="LOC126880017"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GF71"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="38"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="396"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028144907.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="61055" checksum="196956FF86D3EBAA" modified="2020-12-02" version="1">MATTNEQRLSHPPGGDITIEEEKESEICKFYKDKTVLITGATGYLGKLVMEKLLRSCDVKKIFIIIREKKGKDPQKRFDEIFDEPCFEPIKRKNPTFKQKIQVLIGDAQFPNFGLSDEDIETLKAECQVVFHYAATVRFDEKIRTATYINIRAVRDLINITKEMKHLKAFLHCSTAYSNCIHPVIEEKFYDPPIDPETLINLVDTLDENTLQAITPGLLGKYPNTYTFTKCIAEAIVRKEANNIPAALFRPSIVIATAKEPVGGWINNVYGATGVLLGAALGVLRVMQLKKTNNADLVPADFVVNSSIAAAWDVACDNCRNLDQKKQVREEESKQEKDKTHVYNYVSTPEKPISWREFENLGEKYGKQVPSEKCIWYYFFFTVESYWVYALTKFLLHTVPANVIDFLARCIGKEPMMVKGYQKINKFAEILAFFGLNSFKFSNQNVQSMWKKLNEKDKELFEFSMANLDWSIYFRTYVRGSRLYLLQDTLDTVPKGKVKYYKLMFAHYALLTIFLAVFIKIIMIIFNFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIR2</accession>
    <name>A0A6P7GIR2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ejaculatory bulb-specific protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114337434</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143655.1">
        <property type="nucleotide sequence ID" value="XM_028287854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655158.1">
        <property type="protein sequence ID" value="XP_050511115.1"/>
        <property type="gene ID" value="LOC126887526"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIR2"/>
    <dbReference type="OrthoDB" id="6732024at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028334651" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028143655.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15745" checksum="606F21954E465EB0" modified="2020-12-02" version="1">MSWYLSTYLIVTLVVVVFGAPKTFEENVKALRKINLNDVLKNDRIVRSYIDCVKGTKPCTPEGLAMKESWKEGLDKTCDKCEEEDKIKVKKVVKYIYLNRRDWYDELASTFDKDKKYQTKYQEYIDQLLADPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR64</accession>
    <name>A0A6P7GR64_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114341935 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114341935</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148547.1">
        <property type="nucleotide sequence ID" value="XM_028292746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR64"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292746.2">
        <property type="protein sequence ID" value="XP_028148547.1"/>
        <property type="gene ID" value="LOC114341935"/>
    </dbReference>
    <dbReference type="GeneID" id="114341935"/>
    <dbReference type="KEGG" id="dvv:114341935"/>
    <dbReference type="InParanoid" id="A0A6P7GR64"/>
    <dbReference type="OrthoDB" id="6784484at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028148547.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19473" checksum="6DC151DE844A0B94" modified="2020-12-02" version="1">MVVTIVWMHNWISLILAVVSLFIVILFLFFCTCLEKKKEPTHFYIIDEKGIRRDNVKNELVGASPCNLNLFRRFSLTSEPEHIFTSKNLPFYSINNETGHSSKDLVDSMETTKSFDNLVLQFDGSDLPLTYRDELRSCVSVESLNSFYSAHPSTITRGTSRESFCSLISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTT4</accession>
    <name>A0A6P7GTT4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aldose reductase-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114342828</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149442.1">
        <property type="nucleotide sequence ID" value="XM_028293641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293641.2">
        <property type="protein sequence ID" value="XP_028149442.1"/>
        <property type="gene ID" value="LOC114342828"/>
    </dbReference>
    <dbReference type="GeneID" id="114342828"/>
    <dbReference type="KEGG" id="dvv:114342828"/>
    <dbReference type="InParanoid" id="A0A6P7GTT4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028149442.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35960" checksum="1C26D0C94EE515EE" modified="2020-12-02" version="1">MASKVPSVKLNNGREIPAFGLGTWKSKPGEVTQAVKDAIDAGYRHIDCAYFYENEAEVGAALKDKIDSGAVKREDLFITSKLWVTFMKPELVEPTFQKTLQNLGLDYLDLYLVHWPAALKEGGALLPKRPDHETLGIFSDVDYLDTWKEVEKLAKKGLAKSIGVSNFNKRQLERILENATIKPVNNQIECHPYLNQKKLIAFCKSKGISVTAYSPLGSPDRPWAKPGDPILTEDPKIKKIAEKYKKSSAQVILRYLLQSGVIPIPKSVNKNRLRENINIFDFELSADDVAVMDTFDCNGRVCWYVEAIGHPHYPFNDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GU64</accession>
    <name>A0A6P7GU64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC114342941</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149546.1">
        <property type="nucleotide sequence ID" value="XM_028293745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028149547.1">
        <property type="nucleotide sequence ID" value="XM_028293746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GU64"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659510.1">
        <property type="protein sequence ID" value="XP_050515467.1"/>
        <property type="gene ID" value="LOC126890514"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659511.1">
        <property type="protein sequence ID" value="XP_050515468.1"/>
        <property type="gene ID" value="LOC126890514"/>
    </dbReference>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028149546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028149547.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44257" checksum="3B69BAFFD7594DB9" modified="2020-12-02" version="1">MTTMTEAVYESSAVPYASTFQYAEYNFKNTALELARAQWPNYDDQHYLRSCKWSPDGTCLLTIVRGAGMHVMELPNDLYTGESVGSCRPIVPLIPAVSVPEAGLIYDYCWYPGMNSSNPATCCWLSSGHSGPIHLWDAFSGELRCTYRGYNNQDEVEPAISVTFSADGQNIFCGYKKNVKIFDTGRPGRDFVEYPVSHQASCLVASPAQPGVVAIGTWKNTIDLVSQSDGTFRHLCKLNGHKGGITTMAFSLDGFRLYSGARKDKEIICWDLRVPGRPMFCLTREVNTNQKINIDLSVDGKWLVSGGTDGKVQVWNVSEETYPTVHMQMGLHNDCCNGVSLHPYRPILATASGQHHSQDPLHHSRSTSQYENALCMWWIGTQQDDADLITAIIKAATHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GYG3</accession>
    <name>A0A6P7GYG3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase assembly factor 6 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114343828</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028150473.1">
        <property type="nucleotide sequence ID" value="XM_028294672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GYG3"/>
    <dbReference type="FunCoup" id="A0A6P7GYG3">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657401.1">
        <property type="protein sequence ID" value="XP_050513358.1"/>
        <property type="gene ID" value="LOC126889282"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GYG3"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028150473.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="11903" checksum="71CA9D85A8E1BB52" modified="2020-12-02" version="1">MSFPTREERAKCWDARDQYWDCLDKNSGAAKDQKDKNNVCAGFRKVYEESCSAQWVKHFDRKRNYLIFKEKIEKEGIPNKKENDSSISLPRRVYHQIVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GYY3</accession>
    <name>A0A6P7GYY3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114344709</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151332.1">
        <property type="nucleotide sequence ID" value="XM_028295531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GYY3"/>
    <dbReference type="FunCoup" id="A0A6P7GYY3">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657634.1">
        <property type="protein sequence ID" value="XP_050513591.1"/>
        <property type="gene ID" value="LOC126889379"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GYY3"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049407">
        <property type="entry name" value="Usp38-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF908">
        <property type="entry name" value="DEUBIQUITINATING APOPTOTIC INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21246">
        <property type="entry name" value="Usp38-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="317"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028151332.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="77887" checksum="C84E17652B598841" modified="2020-12-02" version="1">MVFGPIKFGHKMAVKQKVVECATPTKEARLQIILRALQGLSANDGLQDKFCAQVVRSLGTVPIPSDPGSYMKFVEDIKKVQNILSKECSEHVFIALKALLDEISNPDPQKQLSPAMSIVLQLIDEATIPNAVKYILNCGYPEQHLEKAFFTLSIWLTQCFWVENLGPLVLAFMKGLEAEHHYEILIEVTLVTIEPLFKLVMFPKIRKSVGPVVLYMLSRNQHNNPQIFHKTIPLAKTVCDKLDKERSDSSLRFLQEIVQLFIALMEAFPGYPELYQPLNEVIQPFCISTDYKPPLHYKSWTAGIVSPTVDKFVVEKVGLNNLGNTCYMNSVLQALFITKTFRNEVLLNNKAISQLFSKLQTLFVLLQFSKRNSLSPNDILHLSRPPGFLLGHQHDSSEFLGYLLDTLHEQEKNFTNSLENNSADEGATAVLPTVVQQSFGGRTMTVSRCGECTTTSERVDDFRELQLSFPNHSDNQSVQTLLDYYLQPEILSGDNQYHCDICSRLTDGEKITRIVEAPPRLIFTLKHFRYDPTSHQRTKLLQTVVLDDYLTIDTYRYELYAAVVHCGSSVDSGHYYTLAKDKAQWYKFNDSFVSRATTDDLKRLKPPETAYILFYSREDIKEPENLPPTILPTSLQIVLTKDQSEFEAEKNQQTGKSFNFRHNRNDEPPPPNCGGGGFSTSGNMLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZ14</accession>
    <name>A0A6P7GZ14_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger RNA-binding protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114344740</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151367.1">
        <property type="nucleotide sequence ID" value="XM_028295566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZ14"/>
    <dbReference type="FunCoup" id="A0A6P7GZ14">
        <property type="interactions" value="1635"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295566.2">
        <property type="protein sequence ID" value="XP_028151367.1"/>
        <property type="gene ID" value="LOC114344740"/>
    </dbReference>
    <dbReference type="GeneID" id="114344740"/>
    <dbReference type="KEGG" id="dvv:114344740"/>
    <dbReference type="InParanoid" id="A0A6P7GZ14"/>
    <dbReference type="OrthoDB" id="8898434at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000001">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002080">
        <property type="entry name" value="Zinc finger RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000210">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZF" evidence="5">
        <location>
            <begin position="448"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="813"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028151367.1"/>
        </source>
    </evidence>
    <sequence length="845" mass="91843" checksum="D94C6AC94D8B12FD" modified="2020-12-02" version="1">MATNNYFGFTHGGTQYTAAATGAAYQAGQAGYAVATPASAAATYGTRATGYETTYQAQPTAYATVGTPGATSYDYGYGQTAAAGYTTGYDQSAAVAAAAAAKPATYATTYSTQRTTQPQTVQVSATSYVQPVTQTTVVAAPQVTTQPKILYSPATMYVPQHATPKPAGGWQNFRKAGVGVKGVSRTKAPPKPQQLHYCEVCKISCAGPQTYQEHLEGQKHKKREAASKMAAAVTVTSQNRSGNSLRCQLCDVTCTGNDAYAAHIRGAKHQKVLLLHTKLGKPIPPQEPEVLGGSKKSISGDSKINFVAGGGLGSTPQGNGDASKDDDDDTPEADVQPVGQDYIEEIKSDDGKVISFNCKLCECRFSDPNAKEMHMKGRRHRLQYKKKVDPNLVVDVKPSLRQRKIQEEKMRRAAMREEFWARRNEEGYWDNRRYDDEYMGIGPFHRGRPYQSGPFFVGMPRRTESSDDKHVMARHAEIYPKEDEIQSIESIVSNTERALKIVSDQIADAKNPVKKLDPAAAAAAAAAAKAEAEAKQSDTPQKEDGRDNQLFTFQQGDNTRILKGVMRVGHLSKGLILRGEINVQLVVLCADKPTLTLLKKVVELLPPALKQIAPEEAYRVAINAPEAGLNVTGKDGNVLVQFTSPVIREQQEAASGGFDRDVLSRGKCLQALAALRHTKWFQARALGLHSCVIIIRILRDLCERVPTWAPLTSWAMELLTEKVISSVPGMSHLSPGDALRRVMEAVASGILLPGGVGLADPCEKDSPDACITLTAQQREDLTCSAQHALRLIAFRQIHKVLGVEPIPPPKNIYNKERFGRKRRAEEQEGDGGKQFKTEADMNSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H3I8</accession>
    <name>A0A6P7H3I8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114343937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114343937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150580.1">
        <property type="nucleotide sequence ID" value="XM_028294779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H3I8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294779.2">
        <property type="protein sequence ID" value="XP_028150580.1"/>
        <property type="gene ID" value="LOC114343937"/>
    </dbReference>
    <dbReference type="GeneID" id="114343937"/>
    <dbReference type="KEGG" id="dvv:114343937"/>
    <dbReference type="InParanoid" id="A0A6P7H3I8"/>
    <dbReference type="OrthoDB" id="6757181at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028402366" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028150580.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15155" checksum="73D2A15C0D1EED3E" modified="2020-12-02" version="1">MKSFIVLSCVLVAAMASHLPNLPESDRIKLAKVHADCQADPKTYVDEDKLRNLQNNINDHQVGVHMFCMGVKAGLLKRNGDLDIPAITSKVSLVVKDQSKVDGLVQKCAKKSDNSGKTANLLFVCFVQNDIQYYHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6G6</accession>
    <name>A0A6P7H6G6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114347688</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154157.1">
        <property type="nucleotide sequence ID" value="XM_028298356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6G6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659976.1">
        <property type="protein sequence ID" value="XP_050515933.1"/>
        <property type="gene ID" value="LOC126890786"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H6G6"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028154157.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9458" checksum="8798547CD6452CCC" modified="2020-12-02" version="1">MVDDKVEMNNDSESYSSLNTNDPKNVQELTQYVQSLLQTIQDKFQNMSDQILTRIDEMGNRIDDLEKNIGDLMTQAGVEGTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6H9</accession>
    <name>A0A6P7H6H9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC114346770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114346770</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028153323.1">
        <property type="nucleotide sequence ID" value="XM_028297522.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153324.1">
        <property type="nucleotide sequence ID" value="XM_028297523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6H9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028297522.2">
        <property type="protein sequence ID" value="XP_028153323.1"/>
        <property type="gene ID" value="LOC114346770"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297523.2">
        <property type="protein sequence ID" value="XP_028153324.1"/>
        <property type="gene ID" value="LOC114346770"/>
    </dbReference>
    <dbReference type="GeneID" id="114346770"/>
    <dbReference type="KEGG" id="dvv:114346770"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028153323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028153324.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="49028" checksum="490411C6657FC561" modified="2020-12-02" version="1">MEMDIKMERILGFYKSQKYLDCHFKLDGQQIGAHKLILAGSSPSFESLLLGDMGKNVIELFDEHVKFAEFKQVLDYLYTSNINIYSVINAWNLYYIANIYLLDGLGLICLGYIKKHLTINNVVMSYEYADLYNRADLKKICLDDMINYVNSILNCYYHMKPSTIHQILKGLKVHDINLLVNVIKWGIIECEIKNVSILPSNIIERLREENLISYFQINCLDFTKCAEIKDNVILDTLTTLIDIFEWTPDSFDRTMLCHTTVTPNFCHLRTGFKIASRLGLLQHEEFISEFRVSTNMIIFGLSIGTPISPYLNYSLPHFDGDIRVRICYSDRERDVIEPVKYIGQIPYGETDFYINLNNSYVLEPECSYNFRISFRNPNDKEQLPLHCYYMSEILHNRSKDVAIKFYEMNGSIIRGVSFYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IBT8</accession>
    <name>A0ABM5IBT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polycystin-2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129407.2">
        <property type="nucleotide sequence ID" value="XM_028273606.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273606.2">
        <property type="protein sequence ID" value="XP_028129407.2"/>
        <property type="gene ID" value="LOC114325536"/>
    </dbReference>
    <dbReference type="GeneID" id="114325536"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="9">
        <location>
            <begin position="109"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="8">
        <location>
            <begin position="305"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129407.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="79376" checksum="105111887F3157D0" modified="2025-10-08" version="1">MNNTNGLKNEKNGSIHETAFTDDIKKEKKPTTKNKKPTWITRSMAEEIGREEVLKRTLFELLIYVIFTIFATIYIIGFNSTAMYYMNKGLREQFLEHDFTTKNDESITFEKIRTAVDFWSYVEGHMINSFFWESTYGNGEAKDSDGMNILYENKVLGVPRIRMVKVRNDSCIVHEYFLRMFLDCYDEYSEEAEDKEKFGIGTATGWTYYDETVTKSLKYRGKIATYGGGGFYNDFSDTKVETQEIIKNLKDNMWITRGTRAVFVDFTVYNANLNIFGVAKLVFEFPSTGGVIPSDDIRTVNLIQFKTTWGIVVLICKVFSYIFILFYLLEEIREIMYFRGYYFLKFWNYVDLAIILLMLTGLIYSILNMVKVPSAVDTIKKNLKAYGNLEYVNYLEYNRVNILAIALCLIYLKAFKFLNFNRTMGQLNNTLNRCAWDILGFSIMFFIIFFAYAELGYLVFGHQVENFSTFSISMFTLLRTILGDFNYPEIEEANSVLAPIYFITYIFLVFFVLLNMFLAIINDTYSDVKTEIALAPDELQMTEYIGEKLAKLFRKWGSFRRFFPQKLKKEIKTTLREIRDVLKKCGFTDMEIEMFFARYNIDPLTHIKIKDSEQFLQELKTILSSERNDGVHLEDFISQQEKLQQVENAIGRLVDQVRTLLYRLEMMENVIKERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICN9</accession>
    <name>A0ABM5ICN9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129940.2">
        <property type="nucleotide sequence ID" value="XM_028274139.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274139.2">
        <property type="protein sequence ID" value="XP_028129940.2"/>
        <property type="gene ID" value="LOC114325982"/>
    </dbReference>
    <dbReference type="GeneID" id="114325982"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046060921" description="UNC93-like protein MFSD11" evidence="10">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129940.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="444" mass="48692" checksum="67EB0ED64674E941" modified="2025-10-08" version="1">MDRSLRNVMLLGLAFMLVFTAFQTMSNIQQTITDSIVKDDPTYDGDAYYSQAIIYGFFSLFNWSAPSVVSIIGPKFSMFLGGTVYVAFILQFLAPKAWGMYLCSALLGIGAAMIWTGQGNYLTLNSTKKYITRNSGIFWALLQLSMFVGNTFVFFAFKGKTEVDKSTRTFVIITLAAIGAVGLIVLFVLPKAFKEEEDEEEEVEEAKPQGPVEAFLGSVRLFFTMRMFLLNFAFLYTGLELGFFSAIYSSCLGFTKNFENRKELVGISGIFMGLGEVLGGGIFGIFGHKTVKWGRDPVVSTGFLLHILAFVLIFLNLPNNSPFADTDDNAIITSNAILAIFCSFLLGLGDSIYNTQIFSLLGTVYADNSAPAFAIFKFSQSLGAVITFVSAKSLGLHYQLAILLVMSVVGTLCFIKVEWYAKKKAALLSAEKSGKSEEALTGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDF1</accession>
    <name>A0ABM5IDF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130385.2">
        <property type="nucleotide sequence ID" value="XM_028274584.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274584.2">
        <property type="protein sequence ID" value="XP_028130385.2"/>
        <property type="gene ID" value="LOC114326276"/>
    </dbReference>
    <dbReference type="GeneID" id="114326276"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026094">
        <property type="entry name" value="GPS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22654">
        <property type="entry name" value="G PROTEIN PATHWAY SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22654:SF2">
        <property type="entry name" value="G PROTEIN PATHWAY SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15991">
        <property type="entry name" value="G_path_suppress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130385.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43402" checksum="B76C9ABA1A3381D0" modified="2025-10-08" version="1">MPTILPENIATTSKEADHSEQMWKVLKNHILRERARKKQEREQEVEEERLRKEREAREQQDVMTLGETREQILQLEQKLTHLKEEKHQLFLQLKKVLNEDDNRRRQKENTENLISLQQIPGNMVHPQLYIQQQPQFQPPPQQQQQQQQQQQQPPQPPRLVPMPQQQPQPPPQTVFKQSKRPRSPSPPPQVPVTMYHNYGYKTPTVGTSSYQGSPQKDDNRRNELVRAVLWNKDDNRRNELVRAVLWNKTPQYGNQPSAFYPVAPQELPIYYPTNREPARTVYEPQRIQTYHLEPKLSDHYMLRAQPSSHGHVIHPGPMPINQQAPPKLGGSITAGYPVRSQPQYQQAPQASLYTGPARTLYQSPVTYQARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFC9</accession>
    <name>A0ABM5IFC9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131548.2">
        <property type="nucleotide sequence ID" value="XM_028275747.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275747.2">
        <property type="protein sequence ID" value="XP_028131548.2"/>
        <property type="gene ID" value="LOC114327213"/>
    </dbReference>
    <dbReference type="GeneID" id="114327213"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="233" mass="26619" checksum="B91613287C9470F0" modified="2025-10-08" version="1">MPKLRKYDKNKLIEAVKDVQNGTESYRTAEKKYGIPKSTIEFKLKHPEHKDTLGPSPILTCEEENTLVRWIQETASKGFPKKANDLKSSVQKFLTENPRPNNFKDNRPGDGWLKGFLKRHPEVSKRTSEGVTAASAYVSERDIKNWFKNIETYVKEKHLEEVLTDPSRIFNGDESGFQICPSTGKVFAMKGSKNVYNVEKSCSKENVTVMFTFSADGKICVPMVIYPYHRKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIV0</accession>
    <name>A0ABM5IIV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133821.2">
        <property type="nucleotide sequence ID" value="XM_028278020.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278020.2">
        <property type="protein sequence ID" value="XP_028133821.2"/>
        <property type="gene ID" value="LOC114329009"/>
    </dbReference>
    <dbReference type="GeneID" id="114329009"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="242"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133821.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="668" mass="73886" checksum="A6D9C925CAF85E1E" modified="2025-10-08" version="1">MARHRDIRNMDYSDDYDGYDDVYGHSVDDDFFESPSNKQFIYNRDMSQRSSEGDIKEEDEQEAELSDSDRAKLTSCIAQINTTLESVNISRNDLVNIIIKSKFDVERSINTILEDSQYRTATIEKVVTQPEIVQTPQIEQTKVISSTPKTVTNITKGFDLPQKGSFTPRSQSPASGKAFTPRSQSPASGKIFTPRSQSPASGKVTPVNNHTLDFAEEVKQAKGRDSKFDPQQLYQKERGDEKEHLYMVVIGHVDAGKSTLMGRLLCELGQVNQKVLHKYEQESRKLGKQSFMYAWVLDETGEERNRGITMDVGRFQFETKTKAVTLLDAPGHKDFIPNMISGAGQADVALLVVDATRGEFESGFDHGGQTREHALLVRSLGVSQLAVAINKLDTVSWSPERFNEILKKLKAFLKQAGFKESDVTFVPCSGLTGQNLVKKPTESELLQWYDGPCLLDVIDKFRSPDRPISKPFRLSINDVFKGTGTSFCVSGRVETGTLSVGDKVLVCPNREAAVVKSLAIEEASKTVVFAGDQVTVALSGVEMQNVFIGNILCDPQSPVQVASKFLARIVVFNVTVPITKGFSVVLHHQSLVEPVIVSKLITQLNKSTGELVKKHPRFLGNNTSAIVEIQVSRPIALELYSECKELGRVMLRVGGVTIAAGLITQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IL56</accession>
    <name>A0ABM5IL56_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135393.2">
        <property type="nucleotide sequence ID" value="XM_028279592.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279592.2">
        <property type="protein sequence ID" value="XP_028135393.2"/>
        <property type="gene ID" value="LOC114330256"/>
    </dbReference>
    <dbReference type="GeneID" id="114330256"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135393.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="469" mass="52157" checksum="F8E8020B72BC4455" modified="2025-10-08" version="1">MSYEKCALLEKPDCSDFPQKVAIFIGCIPSFITGLIIAWPSPSIPKIVNDKVNYDISEDEASYFSFLNATGPVLLSVFISKLCDTLGRKRTLMLSAIPHAITWIMKAFCTNINALYVARALGSLGDTFMYNSLPMYIGEVCTPRVRGVWGNGLICALYLGLFTINTIGAYCSVKLTALICLVFPIVFFILFCFMPESPYYYTIKGNDEAAKQSLKWLRSSDNVEEEFIKLKDNVNKQMSEPSSWKDVLTVESNRKACLAGVFLRVSQNFCGLLAFSVYAQYIFENAGDIIDPKVSSILYTGLSFLCYIIASNFSDKLGRRLSYIISISLTTVPLFVIAIYFVIKEYAPQLHITNYDFLPLVCMIVYIILASFGTGLVPTLMLGELFAANVKVKSLSIVTTFFSLSFCAANNLFYYVSKYCGIFGPFFIFGGCNIVSAIAASVIIPETRGKTLEEIQHQLKKKAQNSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INV2</accession>
    <name>A0ABM5INV2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028137634.2">
        <property type="nucleotide sequence ID" value="XM_028281833.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281833.2">
        <property type="protein sequence ID" value="XP_028137634.2"/>
        <property type="gene ID" value="LOC114332108"/>
    </dbReference>
    <dbReference type="GeneID" id="114332108"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1459"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1336"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137634.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1772" mass="202896" checksum="D687510C304D8A9D" modified="2025-10-08" version="1">MAPTKKVRTYVNSNTSLVNNSIDAFNILFAKNMTKRLLGRKKQKIKIQELPTRRNCESLLNDDSLQISTEDTFDKLLKTKKTPPKLTILESSNSNSVNESKVFLSSPKTRRQKANFSLTNDSNSQQSQLSRLCQPSTETNDSNSQQSQLSHLCQPSTETNDSNSQQSQLSRLYQPSTERIEESLEIEIVKKKQPKTSLSYITIPKNKSLMENSSNFAANMQKKLIHCSTPIAASKAQIQNYTISPINVNSLLKKSFEQIDSWNNEFPAPTSTNTPLRRLVIDKNHSKYVKSSKVLKEYSPTVNHSKDFNSPGTRTSFITLRHRKVIKSYRKRHKNISRKNKVISFESSRQSIVNFVTKRKNTNEKHSSHASFKESDNINEEKNKELCIQMRNLSVSDVRNSVTNFEKFYSRNLSSQLMDNTEDLSDVQGTSKVRSLFVSLSRKSLDCEDFEEFFVSNINHQINSKSRSKENLRHLDISKNKVEYVSDDNNVITNHVEMQNAGCDQDESETKNDVEQKCLRATTVKLQKRKSQEDTFDDFLRKNMKVIENNECSSNYSEDGSSEISSKFTYNKSDISYKRSYYLRSNSEVQQCEIQNCSEEYFFKTLNLTNNKIGYKKKKCKDLRINLTNLPLLQSKEDEFESFFVQNLGRTGKDEYVHKEDQKDLSQTPNRLKVVLNNNFGHDYLENKGLEHNRIVDLRINLRNSPLVQSKEEEFETFFASNLSRDNQDHYVSEENQQQELPVIQKELRVVLKNIFGQNYLKDVVLDHNQTKDLRILTNSPLMESKEEDFESFYASNLDLSNEEQVPKEDQDTLPLKQKQLKIILTNVNNAIINKYTDDNRISSPNGDTSSDEECQQISPKHVFSNKQLVVKLIENDYSHLMPISNVSLVRDKQNLDIVETNLTTEVYSELQVDKIFMNVSNKEHFETFYTKNYGDKTDLLSNSSYDSDIIESSIIDTFAIDTKRTKNRFTREISSRTRSSKCSITDNIKSKRSSKKSVFVHVTAEDELISDDEDARCETIGQADNTLQPNSIQKSRANNSSQNNRIFSVHITAEESFTSPTDNGEEEIILNNESRNLRSYKKSTNNILDSSEHEINISDSSTTEKSLYKNSRSKRNTLKSKENISLNISEDSTAKEGSPNVKKKSSKSRTQRINEDEEKSSSLSVQVSYALKDCAESSNILVDNRISDVRIKETDAIRSNETLSEVEGSTNLDGDYVLSAKNRSSKHRKLRSKRKNEEEIEHVKVHTSRSKNNTLVSESPSKINEANTNSASNVSQEKNQRLSVISDHVDSSYVDPNHFKVPKSFKSPKAVILKAGKSWRRSLSLYKRSTLFSKPAKDDPSSPFTTKAVTPVKSPRSNPSRLSVRFVAVKPLPVLQVENNTVLEDYAINASYVPDQIFEASLEDSFGCLSLTQNQQRNNSISKNQQLGVPVTAREIVLRKCGQTEPIQFSQCFTDSILQNCQKIGEGVYGEVFLLRNPDGGTSVLKIIPVEGDQIVNGERQKKFEEVLSEIIITIELSNLRHNKRNGISSFTEVQKIQCVQGTYPEKLIDLWDLFDETRGSENDCPDMFKEDQLYIVFQMAYGGKDLESFVFNNAMQAYSMFQQVALGLAIAEEELQFEHRDLHWGNVLISTVETNKIASFTLENKTYDIPTIGVEVAIIDYTLSRIEHDGVVIFNDLGLDPDLFTAEGDYQFDIYRLMQEKNRNNWKDFEPFSNLLWLHYILDKAILGLRYKAPKSKLHKAYLRKLKNVKDDILSYHNVKDFIVANLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR34</accession>
    <name>A0ABM5IR34_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139267.2">
        <property type="nucleotide sequence ID" value="XM_028283466.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283466.2">
        <property type="protein sequence ID" value="XP_028139267.2"/>
        <property type="gene ID" value="LOC114333570"/>
    </dbReference>
    <dbReference type="GeneID" id="114333570"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043536">
        <property type="entry name" value="HCF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059124">
        <property type="entry name" value="Kelch_HCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003:SF1">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13854">
        <property type="entry name" value="Kelch_HCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1135"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="940"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139267.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1351" mass="145295" checksum="BA619C8CC72536C3" modified="2025-10-08" version="1">MAGKALKWKIVADTTGPHPRPRHGHRAIIIKDLMVVFGGGNEGIVDELHVFNTATNQWFIPITKGDVPPGCAAFGFVVDGTKLLVFGGMVEYGKYSNELYELQAAKWEWKKLKPKEPKFGNLPCPRLGHSFTVVNSKVYLFGGLANDSTDPKNNIPRYLNDLFTLDIKSNPMQWNLPQTNGPAPTPRESHSSVAYVDKNKNSFLIIYGGMSGCRLGDLWFLETETMTWVQPQVSGISPLPRSLHTSTLIGHKMFVFGGWVPSNLSKDVNAIETAWKCTNTLACLNLETMSWDEINIQQQADLPCARAGHCAVGISTRLYVWSGRDGYRKAWKNQVCCKDLWYLDVDKPPAPSRVSLVKAGTHTLEVNWTGALSVQTYILQIQKYDLPPPAASKTPATAAPVIPSLVTVPKVIAPVLASSLQTQPTTSTPTIKAISSTNQVQSPKIISPVATRVPQMKIQGTTGTIIRDGSPQVAGKQLIMKQGGNIIQKAGAPQQVITFVKTSAGMTLATIPKGSNVVQAKPNVLPQSPKNTIVKIIPTTAANKVQTSIKTIPYHLDKATGKLVPLKTMGQIPTIGNQQVLVMNSNAGLKNIQTLSNAQSLNLSPVKTTSINTQPIVTAANLTNLTNLQGVKIAGKPITISMPMQVVGSPKTVTLSKNTKQVMIGGKPVTVQMATGTNKTLTLVQPNQSAAVGKIVRLPIGSTINHSGNSGEQPKLMVISRPKQPNANIASTSFDSPATTDAALAAIAAEAGLIDPAPEGGVGKLDGSEGNATQTVVLSQGSSTSNVAAPVQVLGSGSIMQQLGLKGGARFQRPPKSFRYRLGLYGGGGVDDVDEEMKPSTTTAEADSTQATVNEIAPSSSNAEIIKMDWESDSTPKQSEESLSVEAKSDSETKSEAEAKPEETTQIEAESEADIGTDVDMRLETEEQSGSKDNLEPETSKNTLEPETSKNTLEPETSKNTLEPETSKNALEPETSKNALEPETSKNTLEPETSKNTLELEEKSESENNLEADKKPETDDKSEAEEKSEQSSQIESDITKSPEENQAKSESGPEETKSEMETDIKKPVLGDLSSSDSVKMEVDIKKEEPSIDPNCHTYSQNITTLKTDEMVPEVKKGILALDDDPLAALATAALAENNSHDPEVPLKDTWYTVGFIRGNSCDVKSYFLLNEDTENLTLDTLPSTVNYPAGFNLEPGTAYKFRVAAINSLGRSDWSEVSAFKTCLPGFPGAPSAIKITKSVEGANLSWEPPSANQGEILEYSVYLAVKAKDKVNTNAGQLAFVRVYCGPNNKCVVSNNSLSAAHLDTTTKAAIIFRIAAKNEKGYGPATQVRWLQDASSKTKRLADSSPKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWU7</accession>
    <name>A0ABM5IWU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mesoderm induction early response protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145944.2">
        <property type="nucleotide sequence ID" value="XM_028290143.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290143.2">
        <property type="protein sequence ID" value="XP_028145944.2"/>
        <property type="gene ID" value="LOC114339478"/>
    </dbReference>
    <dbReference type="GeneID" id="114339478"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045787">
        <property type="entry name" value="MIER1/3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19426">
        <property type="entry name" value="MIER1_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145944.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39053" checksum="8D0419E15B7DD3E1" modified="2025-10-08" version="1">MERSKRFADKMSTDEEENASVSSVETLANDFVEDIRLERDDSSSSGENYVLSRMKKKVLYLSENQENESPRRSIHKAPRHATLRPFYDNSHDKYPDASRLLRSKVNEDDDSHYSYNPDDIESHPIMKTIMVGSDYQAQVPEGLCNYGDALPYENDDKLIWDPYNIASNEVEDYLRKAASIQNPSLPNGSHLRDNEQYLFLLQQCGHNVEEALRRLGMNTAIYNDKMSPWSEEECRNFEAGVRAFGKNFYLTQQNKVRTRSVGELVQFYYLWKKSERHDIFANKVRLEKKKYALHPGVTDFMDRFLDDQDTRDSSSPPTAQVVEDKRNQDNQNISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXM8</accession>
    <name>A0ABM5IXM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cuticle protein 16.5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147369.2">
        <property type="nucleotide sequence ID" value="XM_028291568.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291568.2">
        <property type="protein sequence ID" value="XP_028147369.2"/>
        <property type="gene ID" value="LOC114340794"/>
    </dbReference>
    <dbReference type="GeneID" id="114340794"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007614">
        <property type="entry name" value="Retinin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34931:SF3">
        <property type="entry name" value="FI02976P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045786483" description="Cuticle protein 16.5-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147369.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="26858" checksum="592D3FBF0A40BFD5" modified="2025-10-08" version="1">MFKLVVLFALVALTVAKPSGVYLESPLVETYSLPVVSSGVSHTYRKDVISEPAVVAYSAPAVVSAPVVQEVVAPVVTKVASPVLAVPSAVSHTYRKDVISEPVVAVHSAPTVVASPVVEQVVAKVAVPSAVSHTYRKDVISEPVVAVHSAPAVVASPVVEQVVAKVAVPSAVSHSYRKDVISEPVVAVHSAPVVAEVASPVVAAHYSAPVALSSAVSHSYRSDLHQPIVASYSLPAVEYSHVGHVAPVAYSAHVPAVHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXZ9</accession>
    <name>A0ABM5IXZ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148323.2">
        <property type="nucleotide sequence ID" value="XM_028292522.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292522.2">
        <property type="protein sequence ID" value="XP_028148323.2"/>
        <property type="gene ID" value="LOC114341711"/>
    </dbReference>
    <dbReference type="GeneID" id="114341711"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.290">
        <property type="entry name" value="Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023222">
        <property type="entry name" value="PsbQ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF333">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0793">Thylakoid</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="206"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="796"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148323.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="930" mass="105623" checksum="E9B04EC393501C09" modified="2025-10-08" version="1">MSGVFGYSREAVRVKVKKCERNQPPEMRKFSVDPQITSFEVLQSILAKAFDLKGDFTVCFRIYDVNGYETYMPILSDWDLDAAFLKAHNASVASNSEPCLSLRVDLKPFEESSDDWEIKQNVPIITQIRTVTSQEAKPAPRLHGIFNQVGKTLNLVQRAFNFGEDGNTTLQPPRPPLSDAEFRRFLDPVGQIMYAKELRSVIYFGGIEPSLRKVVWKHLLNVYPSGMTGKERMDYIKKKASEYVNLKETWKTAIAQGQVAGELAYTTGMVRKDVLRTDRHHPFYAGSDDNQNIASLFNILTTYALNHPKVSYCQGMSDLASPLLVTMNDEAHAYICFCALMQRLCTNFMIDGIAMTQKFTHLAEGILYYDPEFYNYLKIHQADDLLFCYRWLLLEMKREFAFEDSLRMLEVLWSSLPADPPDKELKLFDTMFQPTISTPPISPLVKTPRENAYTKIIALRRQSSSMSLSSYNSKKTQQVKRQNHSLDESVSKTKAISVVKTKYQSLDDAVLQKPGEISPKSPKNCDFSPKNLDFSPKNSDSSPKTSEISNCSLRSELRPRSISPLEQKSDSVVLNNRINAHQMLSRKSTSLSSSMTNLIKNSKRTGHFKDLKEKLFSSLDRLDATHSIKEEEESRPYQGRLVKNLNEFLNLSTVSKLETSEKPKIMLTKSSLDDSESSSISRHYSSTSNSGDDTSPDDSQEYFPLTTSVTRELRLELENLDRKVFGDKFVDRLSESPASENDSTVTKEVELKDKRKSDDVFLWENPLHQKTPSVSKLNTHTPDEQADIDFDAPEAVTTPEAQPDPEDATDEVDSKPLTTELPTSNGTVPAMTNSCEEVTESVKTSSLLPSPNEFGGGNPFLMFLCITLLMQHRDHIMGKAMDYNEMAMHFDKMVRKHNVTRVLNQARQMYARYMKQHSIAQQRVEKNEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZB5</accession>
    <name>A0ABM5IZB5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151803.2">
        <property type="nucleotide sequence ID" value="XM_028296002.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296002.2">
        <property type="protein sequence ID" value="XP_028151803.2"/>
        <property type="gene ID" value="LOC114345178"/>
    </dbReference>
    <dbReference type="GeneID" id="114345178"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10974">
        <property type="entry name" value="CE4_CDA_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF5">
        <property type="entry name" value="CHITIN AND LDLR BINDING DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045081171" description="Chitin-binding type-2 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151803.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="519" mass="60496" checksum="41CD600FB5448352" modified="2025-10-08" version="1">MGVSIFLVFKCLISIMAVEGITISDNKKARCVENGHFYRDPDRSAHTMWTQEECSKYFLCLDGEVFDFKCSTGLLFDVNRQICDFKLNVDNCDLTTEAVIPKPLLKTANCKERNYLGCADSTCLPQEYFCDGSVDCPDGSDEGHCDIHNDPNAASPCNPKKCSLPDCFCSENGTKIPGNLQPSVIPQMIMLTFDDAVNDDNWDLYSRVLFSKFYQNPNKCPIKATFFISHQYNNYQYTQKLWNEGHEIAIHSITHRGPEDWWTYNATIEDWFDEMVGQANILNRFSKVRMEDIKGMRVPFLRIGWNRQFLMMKEFGFVYDSSMVVPFSNPPLWPYTMDYKMPHRCVGSKQLCPSRSYHNIWELPMNQLEAGEFTCAMVDSCPSTMTGNEVYELLMHNFRRHYLSNRAPFGLYFHSAWFKNSSYLSAFQKFLSDVLKQTDVWFVTNWQAIEWMKRPRTLDKIHTFEPWSCKKRFEKSEIACSVPNVCKLHSRVFQQDRHLQTCSECPQKYPWIRNEFGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J085</accession>
    <name>A0ABM5J085_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155490.2">
        <property type="nucleotide sequence ID" value="XM_028299689.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299689.2">
        <property type="protein sequence ID" value="XP_028155490.2"/>
        <property type="gene ID" value="LOC114349347"/>
    </dbReference>
    <dbReference type="GeneID" id="114349347"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="124"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155490.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="47734" checksum="E9EAA75F18C3138D" modified="2025-10-08" version="1">MENNKIVSYIRKALRADCYEDFSIELQGRKTNKTEGYASDMVFAKIKLADFDKKLQEHHLAIKFSKASMRKFEVFRNMYKNELLFYKDIMKVFTDHQNKQNVSEPFKAVPKCHGIFSDENVDIIALDNLYQQGYVLHDRHITMNMNHLKLLMKTYAKLHALSLSLREQQNGSFLKILENDLIIKKNADFGTSDFFNACVVKVSKDLREAKRLGLSRKFDELMEKGINEIIHDIIVTENPELSVMVHCDCHNNNFMFKYQDNNKENPHDMAIVDWQLVRYHSPVIDLSFILYSVASKPEINESTALLKYYHEELTRFFTELGNDANSIFPYSLLMDHWKKYAIYGFAYACCYMDFNFVKPDDAPSLDNLDDMSSVSENLSVINLGHNEKTMYTERLITIVEHYFNNINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0E8</accession>
    <name>A0ABM5J0E8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155589.2">
        <property type="nucleotide sequence ID" value="XM_028299788.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299788.2">
        <property type="protein sequence ID" value="XP_028155589.2"/>
        <property type="gene ID" value="LOC114349414"/>
    </dbReference>
    <dbReference type="GeneID" id="114349414"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155589.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="193" mass="22109" checksum="AA8B8F2FA013EAD9" modified="2025-10-08" version="1">MLFLKDNMTQRNSTGNIPPLNNQENSYDENTTPDTISEPDYGRNHNSEFNSDSELNTDTMPTTPKAAKIAQANKETGTKSKKAKSSVYEKMIAIEEEKLKAYREKCKERTKEEDSHFHFLMSLMPYMKKIPEDQKLSVRIKIQQFLLDAQPRAQSVRTRTTAVDQETDQSRYQVVLSSASSENELGCSDVRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJV2</accession>
    <name>A0ABM5JJV2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498217.1">
        <property type="nucleotide sequence ID" value="XM_050642260.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642260.1">
        <property type="protein sequence ID" value="XP_050498217.1"/>
        <property type="gene ID" value="LOC126879208"/>
    </dbReference>
    <dbReference type="GeneID" id="126879208"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="464" mass="52162" checksum="D4D9FB778658BAB6" modified="2025-10-08" version="1">MGVILHFNHKEYEKNWPQILAIVIGGLAGLSNGLLFSWASPFLIKITQDKVNYDITEEEGSYFNTIQPVSLMIACPIFSKLSDVIGRKRTLLLIVVPQIGSWLCAALGRSVYMFYLSRIFSGIADGCLFATLPTYIGEVANPTVRGIWGNAVAMSLYLGEFLINVLGSYLGVTTTSWVCLPISVLFFVLFWFMPESPYYYIMKGQEQEAKNSLKFLKRMKDIDEIYENCKYAVERQLSESGTWSDLFKIESNRKALFAGVFLRLSQQMAGISVFLTFTQFIFQKSGNNMSHEEASIVFMGLAVILNLFAVIFVVKRFGRIFCYTTSMVTTSGVLYAMSTYFYLDGNTNIDLSFVKWIPLACMMSYLLFASIGISVIPTLMLGELYSASVKSKAMTILMIVYGMGNFLTTTIFYQLNTLLGFYAPFLLFAVSNTICAVLSRYVIPETKGKTLEEIQQILKGSMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMA9</accession>
    <name>A0ABM5JMA9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499078.1">
        <property type="nucleotide sequence ID" value="XM_050643121.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643121.1">
        <property type="protein sequence ID" value="XP_050499078.1"/>
        <property type="gene ID" value="LOC126879828"/>
    </dbReference>
    <dbReference type="GeneID" id="126879828"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045553494" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="137" mass="14996" checksum="F857A6F46A023A95" modified="2025-10-08" version="1">MKSIVVVLLSLISLALVACDDSVSTSTDTPVISTEVPAPISTSLREDRVYVDTSNVPDPVYQIDAVEAFKEAKALHPVDGIALLKTFSELFNAKHKVSGGWKVAEKYDYFYNPNINYVYVALGVIDANGDRLVLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNN4</accession>
    <name>A0ABM5JNN4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499548.1">
        <property type="nucleotide sequence ID" value="XM_050643591.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643591.1">
        <property type="protein sequence ID" value="XP_050499548.1"/>
        <property type="gene ID" value="LOC114329633"/>
    </dbReference>
    <dbReference type="GeneID" id="114329633"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="545" mass="61656" checksum="C55B7903E1156889" modified="2025-10-08" version="1">MGTHKVELYIYDLSQGMAAIISPTIIGKKIDGIWHTSIVIYNREYFFGSRGVESCNPGTTALGRPLRVEVLGETQVPYTVFIDYLKGLSESSFAGNTYSLLHHNCNNFSHDIAQFLCGASIPKYILDLPNEVLNTSLGPSFLALVSRLENSARPIREEQTSSIKEPSPDFDQLNSQIEEARYNSFLLEQRRKSIKDKIAKKEKKREKKRKKILESGGVLPPELTDNVTMADTEAVNGQTQLPSDQALAMEEEERREEEAKKKARDPPIVYKDIIDVKAEFDALVALIDGKLTPEEQRATEELQQYMIGDEGSWALSDGFLDFVGRLLNDPQLSVDVRVKTVNVLAMAALKDDVILVLHQDRKDHVLMNYAFEIDRLSMPEQEAIAVFMANMFENLSSSEWLLYISEWSYNNQQTSNIRVTTKVAVHSLLSDSPVLQDRGSAIIHNLACKEKFRNFRIRQRFPKGSLSKVFDDVAVELTMALLQYFNSKPPEEQLFRCLKALAKFVQVSTQEVPQLIQMIGPDPRSFKGTSERIDILVDQIAAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPC3</accession>
    <name>A0ABM5JPC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050499790.1">
        <property type="nucleotide sequence ID" value="XM_050643833.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643833.1">
        <property type="protein sequence ID" value="XP_050499790.1"/>
        <property type="gene ID" value="LOC114341629"/>
    </dbReference>
    <dbReference type="GeneID" id="114341629"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF69">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="177"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="281" mass="30578" checksum="D9BD92691B71B4BC" modified="2025-10-08" version="1">MSLTTNVPELTEKIGFIGGGKMAKAICEGIVNKGLVSYQQVYVSSTVLENLSWWKEKGCYVFQEIRFVTPNVDVIFICVKPEFEFVLNQIYNIPACRELFAPKLYLSFMAGISLNWLDNKLNTSKRERIVRIMTNTPMTVGEGCSLFSGKGATKDDMKLVNKLLSATGTCKQVPEYILNAAEALIASGPAFIYMAIEALADGAVKMGVPMDLATELAAQMTLGAAKIARDSGKHTGQLKGEVCFPGGTTIQGVHALERGGMRAAFIDAVECASKRADQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ47</accession>
    <name>A0ABM5JQ47_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500059.1">
        <property type="nucleotide sequence ID" value="XM_050644102.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644102.1">
        <property type="protein sequence ID" value="XP_050500059.1"/>
        <property type="gene ID" value="LOC126880304"/>
    </dbReference>
    <dbReference type="GeneID" id="126880304"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="397" mass="46634" checksum="BB360D62E2681001" modified="2025-10-08" version="1">MELCSEQKVILEKVAKENGFKNYTIKSERASNTGDNFVGVLNRISIEENARKIAVIIKSTKSGVEKEIQNPRIPFLREIYVYDQIFPTYAKFAKEFNIKDVFKAHCKCFGTCDEENKEYLVLEDMREHGFKMCSKYETMNSFHVEAVIREYAKFHSLALAMNTKRPEQFIKLTKGIFKDVPQQHRADVQKIQMLNLYNAVKGDQLATDVVKKFENQLNEAIATDTNDYVVIIHGDTWCNNMLFKYEDINNQEKPAEVCIIDWQISQLGSPANDLVNFLFYNGSEKILDDYEKYLKIYYETLRNNLKEFSCDAEEILPFERLRKMFKNYCGCSLWNCVLIMRLQMCEHEVPDIKNIKSLMENGATMEDLVNFKIRRIDEYYRRLGVIIKFMIKNSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS98</accession>
    <name>A0ABM5JS98_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500817.1">
        <property type="nucleotide sequence ID" value="XM_050644860.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644860.1">
        <property type="protein sequence ID" value="XP_050500817.1"/>
        <property type="gene ID" value="LOC126880798"/>
    </dbReference>
    <dbReference type="GeneID" id="126880798"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="207" mass="24564" checksum="FB9C7604562D6CD9" modified="2025-10-08" version="1">MDEVKEMCADIMKMVKELLQENKENREKIKNIKEENQQLRRDLEKLKGRLEEMENKLESKDKETTKNNIVIRGIKIGQPDANKQIEQLIKEKLKLDIKITNVQNISLRENKQLTIATVANLTDKKAILREKRQLKGTHIFIDEDLSKNERKIQKIIRDRANMERKQGNRIKMGYKKLWINGALWRWRNEGEKLERNEHTSASPNPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT42</accession>
    <name>A0ABM5JT42_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501103.1">
        <property type="nucleotide sequence ID" value="XM_050645146.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645146.1">
        <property type="protein sequence ID" value="XP_050501103.1"/>
        <property type="gene ID" value="LOC126881103"/>
    </dbReference>
    <dbReference type="GeneID" id="126881103"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="572" mass="67374" checksum="2B0E1D3BEF381D4D" modified="2025-10-08" version="1">MEVKKEISGETCKIEIEYNDLDDALLDDFKCEIQDEPNRESIPGTYYDSLDLKKSPINTEHGNKLNSFEEIQETEKDYLQDENKIEVMEKLIQDSSYRGNDMSRHTEEKTLNKAVNDVTGKRPHKCEICFKQFTHKCFLKMHVRVHTGEKPHKCEICFKQFSETSHLKRHLRVHTGEKPYKCEICFKQFSEASHLKTHLRVHTGEKPHKCEICFKQFRDAGTLKRHLRVHTGEKPHKCEICFQQFREASHLKDHLRVHTGEKPQKCEICFKQFSKAGTLKIHLRVHTGEKPYKCEICFQQFREASHLKDHLRVHTGEKPQKCEICFKQFSKAGTLKIHLRVHTGEKSYKCEICFKQFRDAGSLKRHLRLHTGEKPYKCEMCSEKFTHHGSLKQHLRVHTGEKSYKCDICFKQCRDAGDLKRHLRMHTGENPYKCDICFKQCRDAGDLKRHLRMHTREKPYKCETCFKQFSSTGSLTVHLRVHTGETLYKCEICLKQFNTTSSLKKHLRVHTGEKPYKCEICFKQFSEAGNLKRHLIVHTGEKPYKCEICFKQFSQTGFLKTHLKVHTKERSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVG2</accession>
    <name>A0ABM5JVG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Farnesyl pyrophosphate synthase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501927.1">
        <property type="nucleotide sequence ID" value="XM_050645970.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645970.1">
        <property type="protein sequence ID" value="XP_050501927.1"/>
        <property type="gene ID" value="LOC126881608"/>
    </dbReference>
    <dbReference type="GeneID" id="126881608"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="44833" checksum="B96A7458BFF7E754" modified="2025-10-08" version="1">MLKTILKNMCSKSTQLVWFSSQNVNKNINENSAFKTECKPVDLSFETNKMFAALPSICEEIVDEQLIYHQAYPEIRERYSNLLQYTVNIDQPRYSGKGIFFLHAYRMLEKPSILTDDNLKKACVLGWCQRMMDVSIIINDDILDVSDWRYNKPAWHSLENIGRNKAILDATFVESSVWYLLINHLKSHKFFADILKQVLMSYTITNLTQCLELTKYDVKELEKYAYSARGYGFTSPILRTALYLANIDDKDAHDFSQKISNELSYFMRCEDDFNGVFNPMSDIQKSCTDISEGKISWLAIQAYQRSSPAQKTILEQHYGKANKESVSNCYELFQELKLNEVFTKYREDFYNHIYLSVQKSMPKKLPKELYLNFLNFCMTGALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXM9</accession>
    <name>A0ABM5JXM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502694.1">
        <property type="nucleotide sequence ID" value="XM_050646737.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646737.1">
        <property type="protein sequence ID" value="XP_050502694.1"/>
        <property type="gene ID" value="LOC126881985"/>
    </dbReference>
    <dbReference type="GeneID" id="126881985"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="76244" checksum="BA1D9A9B7976DC79" modified="2025-10-08" version="1">MAFIIPDNILETLTCTFCHKYLSVKPIIVYPNRDVGCGRCAKIKKQKNGGAGVESLYGKIADKWLFKCINRFDGCRELLTCSQVPDHEQVCSEKIHMCPICYEEMTGFQMLQHFHSNHKDAILDCPAFVFNLYDHSEMPSTYIYQEGDNLFFLYISYSKSENTIKLELVYMGSNKVASNIYHQFTVTSENKEFFINFSSKPSCANEFSLGDTSNMSGLIYIKFKIIYQNLKFCTITENENSSSSSINNSLKKLKVNKEETNQIIEFSPECNPQCFICKEICIFSFYDTRTIDYYYSPIYHDFICFYCFQWLTCKDKIKEFHFYVKHSIPSTFRSRFCKWDCGKDFKFSEIVPHEIFCEKRTQYYDCPVQNCQFQSFASPLSNHLKTDHDYKVYASFFQITKLPIKCFLFVEDQIIHFQLTAQNEYNMECNIVSNDHKIKSEWKPHVLFFNGQKLTPLVNLPNTSSTNLSFSATPLVNHPNTSTTKQSLSATPIANHPNTSSAKLSSLVTATVNFPKSSNNNPTFALSNSSSTILSSNAPPLGNLPETSNPNAVFGLPNTSSTNLFFSATPIVNLPKTSNPNPAFALPNSSSTNLSSSNTPAVNLPKTSNPKPAFALPNTSSTNLSSSTTPVVNLSNTSSTNFSFDGTPLYDKIVFENIYSNLSWTAKIVLVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZR8</accession>
    <name>A0ABM5JZR8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503432.1">
        <property type="nucleotide sequence ID" value="XM_050647475.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647475.1">
        <property type="protein sequence ID" value="XP_050503432.1"/>
        <property type="gene ID" value="LOC126882508"/>
    </dbReference>
    <dbReference type="GeneID" id="126882508"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23611" checksum="C1152C446A4F9992" modified="2025-10-08" version="1">MLNLSLQGRNQTVSDLIGMINGFRNKLNVFKRALEKNNLTHFPSCLQIAEEFNGEENIEFSSCISQNEQVIDEFNTRFEEIESLKSSVLLYNNPLGATIDDQPPNLQLELCDLQADMFLITRQEKGPELFKLLSKEKFPNLRDFGLKIMSMFGSTYTCESAFSSMKNKNRSNLTDSSLRHLMRLSTTELEVDISSLVDEADRPQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0C9</accession>
    <name>A0ABM5K0C9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503646.1">
        <property type="nucleotide sequence ID" value="XM_050647689.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647689.1">
        <property type="protein sequence ID" value="XP_050503646.1"/>
        <property type="gene ID" value="LOC126882708"/>
    </dbReference>
    <dbReference type="GeneID" id="126882708"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35887" checksum="D991183E3897686B" modified="2025-10-08" version="1">MASVTHKCVYAGCFERNDGTNNNISFFKFPLKDVERTKIWQKNCGNIDILLMDITDLIQRVICQHHFAVEHIYQSGQRKLLRKNAVPLKFTQLTTDLGDIPPVCSTYVYCGTKRKRSTSDDCMVRSTPSPKRSSSSLSDISSFEINLPTKLETELTEKVKKLKYQVNALKKKCHNRNCEIAQTDNLDLTHEVTSVEISDESIETQTVHVEQSLDMQKENNDNQILSTAHSSKCSITNLETCAVTYVAGYIYYKIIKNLNCGNVAIIRRIKRLLMETFKEINPEALKRGLKISETKTKYMTLIRTSDNENNAAVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2Y9</accession>
    <name>A0ABM5K2Y9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504554.1">
        <property type="nucleotide sequence ID" value="XM_050648597.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648597.1">
        <property type="protein sequence ID" value="XP_050504554.1"/>
        <property type="gene ID" value="LOC126883270"/>
    </dbReference>
    <dbReference type="GeneID" id="126883270"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF111">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="514" mass="56480" checksum="310D72D0EB9313B1" modified="2025-10-08" version="1">MITIIHEDEVCDTSRLVWMSLPVKMTEHRREPILNEKVTLAKWLKHNSLLFLTLIGVILGAIIGSILRQVDVSETTVLLISYPGEIYMRLLKLLILPLILSSLITGSSSVNAKLNGKIAIRTFLIFFISSALNALLGTVLAIIIHPGDPGLNISLENAIEDKKGSSVLDSLLDLGRNIISDNIFQATFQQAHTDYINSTIKMLKNNQTVEISKVERFLGTRPGTNNIGIVFFCIIFGSILGTIEEKGNVVKEFFSTIFVVIMKMVKGVVWITPLGICSIIAAKIVSVTDIVLVISQLGWFIATILIGVFLSQLIILQPVYYFFVRKNPFKYYLAFTQGTVTAFATASAAAALPVNFNVLDNDLKIHSSITRFVMPIGTNINMDGTALFLASSTVFLAQMTGFNLGTGTILTIWVTSTIMSFSSASVPSAALVLVLMIVTSMGIPTKDLPLLFAIDWLVDRIRTTSNMLGDCYTVAIVEKLSKKELLECTLTNDESSSERLLNKNNEILNDMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3J5</accession>
    <name>A0ABM5K3J5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504769.1">
        <property type="nucleotide sequence ID" value="XM_050648812.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648812.1">
        <property type="protein sequence ID" value="XP_050504769.1"/>
        <property type="gene ID" value="LOC126883354"/>
    </dbReference>
    <dbReference type="GeneID" id="126883354"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF17">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="405" mass="46960" checksum="74B81959016D246E" modified="2025-10-08" version="1">MAGEITGVHKRITEKYPKALYFHCASHRLNLVVNDLNDIPQIRNTTGTVKEVITFFRQNGQRRTIVGTLQKLCETRWTEKYKAIRKFSEQFVSIAEALQTLSTEGNRDTRQKAFQLHCAVTNTAFVICLHVIAKYSAKLEIVTQMLQGVSVDILKISKHIQKVTELFSSDRQNGEKEFDNIMANVETTANKLGIELTCPRVAARQVHRPNHSTQTINEYYRKSIFLPYLDSLVQSLKDRFSDRNKPSFEIFNLHPKIMKDLSKEDFEKSINNINSTYCELLDNFKEQSILWFDLWKNTEIDAKALEKLNLIEVLEHEHACFLPSVAKAIQIALCLPPTTCTIERSFSTLKRVKTWIRNTMSNNRLSGLCLLSVHRRKIKENKENFMQKVIDLFAMDTRRIQLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4W6</accession>
    <name>A0ABM5K4W6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor II-I repeat domain-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505230.1">
        <property type="nucleotide sequence ID" value="XM_050649273.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649273.1">
        <property type="protein sequence ID" value="XP_050505230.1"/>
        <property type="gene ID" value="LOC126883621"/>
    </dbReference>
    <dbReference type="GeneID" id="126883621"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="503"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68817" checksum="7E653DE42F8BD1C0" modified="2025-10-08" version="1">MEKKRKIDSECRKFKDQWNIQYFVIESSNKALCLICNESIAVLKEYNMKRHYETKHSQNYSKYTGIVRTEKFEALKCGLKSQQSLFTKVKTEQEAATRASFRVALEIAKRGKPFTDGEMIKECIIAVVEEMCPEKVNLLKTVSMSANTVARRVQNIAENISSQLFDKNGHVEWFSLALDESTDVSDTAQVLIYIRGVYKSYEVHEELLDMYSIHGTTTGIDIFKGVEMAINKKNLRWKNLKCITTDGGKNMSGKDKGVVALVSKAVENDGGSKPLVLHCIIHQQSLCGKCLDMSDVLKPVISTVNFIRSFGLNHRQFRQFIAEIGETDLPYHTAVRWLSCGKVLQRFFELRAVIEIFLNEKHRPLTELQNNAWLWKLAFYVDLTKHVNELNLRLQGENQHLPDLYTNIKSFRMKLILFQSQLRSKCFSHFKTCEIFSHTTETEFPIDFAIETLSALKINFDTRFSDFDAIANQIKIFQNPFDADIETLAPELQMEMIDLQCSDIIKNKYENSSLLEFYKSLPLTQFDNLHKFARGLFSVFGTTYLCEKTFSKMKYTKNVYRSKLTDEHLKSLLIIGTSKISPQLQTIVGGKSQLHTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K594</accession>
    <name>A0ABM5K594_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505354.1">
        <property type="nucleotide sequence ID" value="XM_050649397.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649397.1">
        <property type="protein sequence ID" value="XP_050505354.1"/>
        <property type="gene ID" value="LOC126883734"/>
    </dbReference>
    <dbReference type="GeneID" id="126883734"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="651"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="738" mass="83761" checksum="B59C846105F2D16F" modified="2025-10-08" version="1">MDNSKPKQKTLTSFFSASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEGKLGCKVCFEVTTMGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQTIVESSHKNPITQLVDSANTAHMESTKAIFRSAYYIAKNDRPYNDHFGLLELQKLNGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVCGKISIIIDESNSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQVLANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRKTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVIDNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7S8</accession>
    <name>A0ABM5K7S8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KANSL3 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506246.1">
        <property type="nucleotide sequence ID" value="XM_050650289.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650289.1">
        <property type="protein sequence ID" value="XP_050506246.1"/>
        <property type="gene ID" value="LOC126884361"/>
    </dbReference>
    <dbReference type="GeneID" id="126884361"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056519">
        <property type="entry name" value="KANSL3_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136:SF16">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="TESTIS DEVELOPMENT PROTEIN PRTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23154">
        <property type="entry name" value="KANSL3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANSL3 helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="988" mass="108812" checksum="628F988B4C411223" modified="2025-10-08" version="1">MVIEEARYTYPTQLTNSFDRENWTISTEHCYARPWDWRPEASFLRPTKTLFMPKLIPTKPAIPETEELIDVEAEVEVPVPNYDVAKAKTLMNECENQAIAARTDIEVDWEELVSKSNWTSNQNKVFNGMVNILNYFNLSKLAYSGSQNEPLLRRTVIDKGVQRVRRLLASVSWELKLIQWLHQTMIENLPAPYLGSYLDILQTLKSKLPNFVDKMMHVSSANRTNTLSNANLAPLLEKPWDPVSTSLMLYKPKKLPGTPIILIVPSGTAVSKMVQKWTKLLTNLATVITIQTSFGSTGHRMTIPSILDQLFAITRGKIQDIREEYPGKHIILVGFNSGAALAMQVAQVEPVLCVVSIGFSLLTVQGFRGEPDDAILELQCPVLFVIGQLSNTSNQEDLENLREHMRVETGLLVVGCADDYLRITKKKKRQEGITQSIVNRCVVDEIGEFVSGLILSPYPPQVRPPSVHIPSEIPVKKGNAERKRFNSNTSSLDSEPSSPTPIRITRPVGRPPGSKTKNKLETKWAQMCAQGNASANPTSSSPTSPLLYPTTPDTSSNDSCHTDKPSQHFSPSKQPDQSNTPLKKIKTLKPIANTERIVSPVKNQSQPARSQGFSTGRNVVQGNSSVTNLLQGGIKTICPSPTPSNLGIKVLENVTLNCTGGKLYPNRTIDLSKLTLLNSTKSANTSVSNVLLLPDGKIKTIGNTIKGTGGTPILVTSTKSVSRQTTNPGQKYITSKKQLIAQKPPTPIKKSAYKYASNTEPSIPTSNLTTQDIMDLPIIFADDNQIINSNSSTTPHISANTLNSVSSAAATSVSSVPLVSQVTKSGAPMTKYMLLNKNTLGQSNFILTPNVKKTVPITHFNKPVPKYTRILLSSKKTSLNEEKTAPKVQTKPPEITFKNVTPGPLEKQPTISRMDVDDIENLIAASTLHKPMSAIADAKNIKIISKISKDKEGVSHIKAEDIKKRSFSPMKIDKNDPDYVPIKHFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAE9</accession>
    <name>A0ABM5KAE9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507165.1">
        <property type="nucleotide sequence ID" value="XM_050651208.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651208.1">
        <property type="protein sequence ID" value="XP_050507165.1"/>
        <property type="gene ID" value="LOC114332705"/>
    </dbReference>
    <dbReference type="GeneID" id="114332705"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="323"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="833" mass="94633" checksum="8F750BCEABD8AEB8" modified="2025-10-08" version="1">MEQGQINKLTRSKTASKLDLTRLCSSVETDLASLTKYMIKEILCQLRDAFRTYNDATNLLAAELATTEDVDPIVKKYYKCISLLEEKLESLLTPPTSSTTSEISSVPNPNVPSPSSQITQNATTKQRTVKLPELRINNFSGKLKSPESQTADENLSQIVQKFWESEEVNPPISESVENHPSELLFLNTVKILPSGRYQVNLNLKHSVDDLHMGNSFITAKKRFFHLEKKLHSDPVLLQSYSKIIQDYHSQGLVSDVPLQVRNFDGKFNYFLPHFPIIKTSSTTPVRIVFDPNNKSTSGICLNQVLDKGFTVQPELFDILITFRHYTYILAADIKHMFLQISINEQETFLLNFLWRDKQDDKLQCFRFNRLPFGLSSSPFLATRVLKHIADTHAISHPSAAKTLLNSTYMDDVLSGGNNLEEIETLHFQLSSLLSKHGFQLHKLSSNHPEFLKKHKLIPTPEIKLSLAGSSDKILGIIWSPDQDTFSFKPPVCEVTSPITKRKILSYVSRLFDPLGLLSPTLVYSKLLLQRIWSLSLDWDTPITNDKILSDWQSLLTKFQSINLTKFPRCLVLDKKVILTQLITFCDASQDIYAACVYLRVTYDDSTVSVRLVTSKTKIAPLKNKLTIPRLELSAILLGIQLTHRSQGILQKDLKISETHLFSDSTIALTWVTTSKFLYNQFVQSRVIKIRSLSESYQFHHVESKQNPADLPSRAKSICSNAELTDLWLHGPKFLIKPEIDYSLFQIKKWNGELPELRKNQVSLNVTVTAQSNDTLDDLFNRCSSFTKIQRSLAYVLRFVSNLKAKSNHTAIDTDVLSVEEIEFSTCLVLKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBE2</accession>
    <name>A0ABM5KBE2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507506.1">
        <property type="nucleotide sequence ID" value="XM_050651549.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651549.1">
        <property type="protein sequence ID" value="XP_050507506.1"/>
        <property type="gene ID" value="LOC126885118"/>
    </dbReference>
    <dbReference type="GeneID" id="126885118"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="302" mass="33069" checksum="110BFA2AEBDDD2C5" modified="2025-10-08" version="1">MGSFVDPETGSRSCSNKLIFILAPILFKLAASKEPNKVIHRHSFRERVPLPATNVNIEPIAIQNYGDVYTQEYSTDNLKNFDGFYQIISNSLEKPVQESQEYIPSQQSLGPAVIPQYPPLATPVNAAASNVPSNENAVFLGSGSIGVVNLGGGAYVLGSGSLGYSEIRRNPRTSLLMPTLPPIQAHPSLLPAAVNSPEITQPKPIFSYSYPQGQSFPNDPNEYEFLTPDQVGFGDPLPPRRLKITNAYAVPTSLQIQPQVPPPPSPTLPPLFTFAQITTLPPIRSTYNKRNPSFYRSVQHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCI0</accession>
    <name>A0ABM5KCI0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507899.1">
        <property type="nucleotide sequence ID" value="XM_050651942.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651942.1">
        <property type="protein sequence ID" value="XP_050507899.1"/>
        <property type="gene ID" value="LOC126885381"/>
    </dbReference>
    <dbReference type="GeneID" id="126885381"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="310" mass="36639" checksum="A28B3F9CCF0CF347" modified="2025-10-08" version="1">MVDVQCLDHQVSEGKKPVEINEFAKNIIRRKIHGFFFKKEIPNLNKILQEVKDDPDLPNIGRTKLWEVLKELNFRWEKSDRKSVLIDREEIICWRRHYLRSIRKFRAEGRPIYYQDETWVNAGHTLTKIWSDKNILSSRQAFIEGWSTSISPPSGKDSRLIISHLGSEKGFLRDGSLEFQSKSTKDYHEEMTADVFEEYFEQMIEHIPPNSIIVLDNAPYHSRLVERLPTTAWKKQDVLDCLRNKSLTYEDGMVKAELLKIARQHKSKYKKYVVDKMAERRNITVLRLPPYHCEINPIKLIWAQNERLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCL2</accession>
    <name>A0ABM5KCL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507915.1">
        <property type="nucleotide sequence ID" value="XM_050651958.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651958.1">
        <property type="protein sequence ID" value="XP_050507915.1"/>
        <property type="gene ID" value="LOC126885394"/>
    </dbReference>
    <dbReference type="GeneID" id="126885394"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="538" mass="61475" checksum="3710CA283C393CF0" modified="2025-10-08" version="1">MNGVDIGVGLHSRFSATEIIDHISHEMKKRITQQVKSISGKISILIDESTSLSDKSTLIVYLKCETSKDLPPNVLFLDLIELPNQTADSIFEALLGCLKKYGFDFEYLKENLVAFACDGASVMLGKKSGVVEKLLQQFPNIVPWHCMNHRIELAVSDSINDVGAINHFQMFMDKLYTLYSKSPKNQRELAECASELDLQLQKVGRILGTRWVSSSFKTVMAVWYGYQALYSHFKKAQEDKNRTTTERAMYGGLIRRLTSTQFLSDLAIMYDILAELTMVSECLQNREATVVYADKLIRRLIAFFECLKEKPGTKTLEAKRAAITGNFWHVPLTSSNKITAINDQQLLSSVINNLKRRLFTTRSSNEPSNKATGNNYDYEKEYEYLLSELKVLESNNWPPEKYVGHGEQEIEHLCARFRLNANKIKNSFRDYLENSTTIPKDLNPLINCTKLIPCSSAECERGFSHMNIIISPTRSKLTIEHVSALMFIKLNGPSIQTWKPENYVKAWLRRHRTADDTRTRRANLQPDKEEEDAFAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFF5</accession>
    <name>A0ABM5KFF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500811.1">
        <property type="nucleotide sequence ID" value="XM_050644854.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508932.1">
        <property type="nucleotide sequence ID" value="XM_050652975.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516975.1">
        <property type="nucleotide sequence ID" value="XM_050661018.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644854.1">
        <property type="protein sequence ID" value="XP_050500811.1"/>
        <property type="gene ID" value="LOC126880792"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652975.1">
        <property type="protein sequence ID" value="XP_050508932.1"/>
        <property type="gene ID" value="LOC126886130"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661018.1">
        <property type="protein sequence ID" value="XP_050516975.1"/>
        <property type="gene ID" value="LOC126891741"/>
    </dbReference>
    <dbReference type="GeneID" id="126880792"/>
    <dbReference type="GeneID" id="126886130"/>
    <dbReference type="GeneID" id="126891741"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="43204" checksum="65FA856FB59FC71C" modified="2025-10-08" version="1">MERNIEIQKYNLEAKIYEERRKTEEKFDDMLQNIQTNNHHIRNVEQRIEDISQIRDIGRPYLNLTNETGIKFSGNIKNLHPRVYINSLKHKLRSVNNINDIKDYIRMTLSDNAATWFASIENDLDNLQTFENKFLNYYWGELEQARFREVLYFGKYNRNLSLNMVDYALKLITVAKYLEPPLREDETVLNVSRHFDADVVQTVTVQNIQTVDSFINFIQRVQRGYITSNNSKNRQSYNNNRYGSNSQNFNNNNNTSYERQGNRENFNNNTNDNRQERQGNRENFNNNNNYNRQDFNTRRNAQRYNYNRQVNYVRGQSCEDSQRNSTWQENMNSRSESSERHRGLDPNDQTQSDNPNNPNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHZ2</accession>
    <name>A0ABM5KHZ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050509831.1">
        <property type="nucleotide sequence ID" value="XM_050653874.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653874.1">
        <property type="protein sequence ID" value="XP_050509831.1"/>
        <property type="gene ID" value="LOC126886809"/>
    </dbReference>
    <dbReference type="GeneID" id="126886809"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="81"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="212" mass="24091" checksum="A197FCD7DF84F211" modified="2025-10-08" version="1">MPSYKLTYFNFTGRAEPVRVLLRYGGIPFEDVRVEHADWPSVKPTTPYGQVPVLEVDGKKFTQGIPLARYVANIVGLVGKSNEENLEIEIAVNILSEILKTAYESHFDPDEEQKKKHLKTLHELLAKYLPVLDEAAKKNGGHIGANKLNWGDVYFVTAYEDIRNILGNKDIVENYSGLQNVKKNVLSDKNIKEYIQSRPKIPIFVYDLRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI68</accession>
    <name>A0ABM5KI68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509907.1">
        <property type="nucleotide sequence ID" value="XM_050653950.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653950.1">
        <property type="protein sequence ID" value="XP_050509907.1"/>
        <property type="gene ID" value="LOC126886851"/>
    </dbReference>
    <dbReference type="GeneID" id="126886851"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="46360" checksum="3B621A8ADAF939B0" modified="2025-10-08" version="1">MTSAERGSTVTMIGAINAGGGFIPPLLIFPRVNYKDFMITNAPPGTIGGANPSGRSNENLFFQFMEHFIKHVRPSTNAPCIVLFDNHESHMSVPVIDLAKRNGITLVTFHPHTSHKLQPIDKGVFGPFKKYYSTATNEMMLTPGYVGKPITIYNVASLVGKAFPLAFTPNNIMQGFKATGIYPFNENIFDDSDYLSAQVTDRPYDVTSDKTEDTNTAANSDILPQLATEAEISSQSVAEADISSQSVPEADTPSTSAVKNIITPSMIRPHPKAAPRKNNGRGRQKGKSRILTDTPEKIRIEMLKMASLIKQKKRKTNVKVSQQNSTKCKNKKKSVKRKIVSDSESSISDDNFSLQESDMSEMSFEIYDNEIENTNSNSEILKFQLGDFVIFVYGNNYFPGKIVDIKEQEFVIASMENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIS0</accession>
    <name>A0ABM5KIS0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510099.1">
        <property type="nucleotide sequence ID" value="XM_050654142.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654142.1">
        <property type="protein sequence ID" value="XP_050510099.1"/>
        <property type="gene ID" value="LOC126886954"/>
    </dbReference>
    <dbReference type="GeneID" id="126886954"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17057">
        <property type="entry name" value="Ubl_TMUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040352">
        <property type="entry name" value="TMUB1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557">
        <property type="entry name" value="PROTEIN C7ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14557:SF5">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="208"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="392" mass="44279" checksum="3D660254B1E7FFE4" modified="2025-10-08" version="1">MTIIEGIGDEVTHFFIALFVIVIGTVAWWTTNISEQRYIRTVVLLERRRHRAHRRLTNHTESVTITEGSSSTSQTEESTPDLSAETDAALERARAPNGNKPPEPRSEEDLIAPDIPSTILEDSRGEEEESIIETMDADANIVRQRRLAFYTGFSNENQEPTSSHTESFRQNTSSPQDSSTSSEDVEPSAPPTEESVPPKNEDTTSNRITVKLKYINDDLKLVEGNLNESLGEFKKRNFVPELSSNKLIRLIFNGQVLQPDTQTLKNCGLFDNCVVHCLIHQKRSQPNRSSGTESRREGYSFPNTNGSANNNNNQNRDWDLGNFLFGFISIILLAAWYFRYVYAHLYTVTATVGLILITGIFTIVLVGMYFPDTEQFPNPAFHIRERTTPQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ82</accession>
    <name>A0ABM5KJ82_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 15-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510264.1">
        <property type="nucleotide sequence ID" value="XM_050654307.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654307.1">
        <property type="protein sequence ID" value="XP_050510264.1"/>
        <property type="gene ID" value="LOC126887011"/>
    </dbReference>
    <dbReference type="GeneID" id="126887011"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046258906" description="Leucine-rich repeat-containing protein 15-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45609" checksum="673818A6E5B0B952" modified="2025-10-08" version="1">MRFKNGIIIFFVIAIVDEVLSENPNSPCKENWDGGIKCSDCATLRAGQTYFPFFESRPLRYFIAYFECRDNFSRIDIGHDLIDKLQKIEVIKITKTDARRLVAGTFGSTNITNTLRQLYLPNNNISIIDASAFGRMKVLTHLFLNNNKLKSFSSHIITEGVNIKYLNLGNNLFEDMMDTQLYNLTSLTYLNLDGNKFKTISMSKVISNLKPVRVVWMSNNLLTYIGLESFDPVFDIEVLNLSFNKIDNIFGALSFMEKLKTLILSYNNIAELEELDFPLKNLTSLQYLAIDHNQIMFMDPNLLDVLPFLKKITIMGNPWYCNCLRDYRQGLEVRHIQEKCGSDYVDTKRPVCLVDLTTNNTCTHVYSTAAAKFVNDDRRLHLDTDITFCLLNEFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJC3</accession>
    <name>A0ABM5KJC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050510311.1">
        <property type="nucleotide sequence ID" value="XM_050654354.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654354.1">
        <property type="protein sequence ID" value="XP_050510311.1"/>
        <property type="gene ID" value="LOC114325529"/>
    </dbReference>
    <dbReference type="GeneID" id="114325529"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057033">
        <property type="entry name" value="Ubiquitin_IARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23567">
        <property type="entry name" value="Ubiquitin_IARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="25"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="699"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1208" mass="139242" checksum="838754E42716E4C5" modified="2025-10-08" version="1">MTEKKLQQIPRVPESVNFPDEEVKILAYWKQIDAFKSCLKQSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDVVTRYAHQQGFHVERRFGWDTHGLPVEYEIDKKLGIKGPDDVMKMGIAKYNEECRKIVMRYSGDWEKIVSRIGRWIDFKNDYKTLYPWFMETVWWVFKQLYVKGLVYKGNKVMPYSTTCNTPLSNFETGQNYKDVVDPAVTVSLPILDDKEGAALLVWTTTPWTLPSNMAACVHPDLIYARFQQVSTQKIYVMMECRIESIFAADDVKVIKTFPGKELEGLRYEPIFNYFTHLKDKAFRVFVDDYVTSESGTGIVHQAPYFGEDDNRVCLANGAITRDQEPICPIDANGCFVEPVKEFLGQYVKDADKNIIAKLKETGRLIHQSQIKHSYPFCWRSDTPLIYRAIPSWFIRVEHMRDQLQEVISDTYWVPEFVRDKRFANWLKEARDWAVSRNRYWGTPIPIWMSADGSEVVCIGSIAELEELSGKKVADLHRETVDTIEIPSRIPGNPPLKRISEVFDCWFESGSMPYAQVHYPFENVKEFEDNFPANFIAEGIDQTRGWFYTLTVISTALFGKAPFKNLVCNGLVLAADGFKMSKSKKNYPDPMDIVNKFGADALRLYLINSPVVRAENLRFKEEGVRDVIKDVFLPWYNAFRFLLQNIEIYVQNYNKDFVYDENNVKSDNIMDKWVLSFTQSLLLYIRKEMELYHLYNVIPRLTKFFDYLTNWYVRMNRKRLKGENGEEDCYAALTTLFNILLNIIKMMAPFSPFLTETMYQYLKQLLDTKADSIHYLMLPQPNQTLIHVDIERAVARMQSVIELGRVIRDRKTIPIKYPLPEIIVVHRDQQYLDDIIQLQGYILSELNVRKISTTTDKSKFGITLRAEPDHKVLGARLKQEFKAVTQGLKSLTDAEINEMVEKGHRDIAGQRIDISEVRLIFKSESLNSDQYEVNSDNDVLVLMDVTPDSSMQDEGIAREIINRVQKLRKKAHLVPTDEIAVFYKTSGDLSRVATEYTEFIENTLKTPFKCLQSKKASDETIIEEKQKLKDFDIQILLTKNSNIQLPVVKWVNLQLVGLKSKYCKDATKGLVLLEAGSKSLSSENLKEEASRLFNVDKFSLVLKDGSPVNGQNIDKLSSQVVFVVPVDQKPELPSGSSAPFCKFLNFEEKGVKGTIILENPVGNPTKYVYQDVLKLWTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KM56</accession>
    <name>A0ABM5KM56_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511280.1">
        <property type="nucleotide sequence ID" value="XM_050655323.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511281.1">
        <property type="nucleotide sequence ID" value="XM_050655324.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655323.1">
        <property type="protein sequence ID" value="XP_050511280.1"/>
        <property type="gene ID" value="LOC126887679"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655324.1">
        <property type="protein sequence ID" value="XP_050511281.1"/>
        <property type="gene ID" value="LOC126887679"/>
    </dbReference>
    <dbReference type="GeneID" id="126887679"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="256"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="366" mass="42143" checksum="551B9E4C78373395" modified="2025-10-08" version="1">MLVQAIYNFFSVSTHRWELLSRAIKDSAESGQTLLPKRVNTTRWSSRFDAVKALKSNYGLIKTCLIGISTDINEKNIVRVEAASLSEKLDLLENGIILSFWLDVLQRVNEVNKSVQKENMDLSTTAHLLSSLADYFDFLRDRFDHYEALGMLLTGNENYAEKRIIKKKLQLGEMNSEVSLSQTEKIRTQCYVCIIDNLKSEIIRRSDSYKSCSRAFEFLFKLKATEDEDIFRSATELQQNYKEDLDEYFPQECVHLNHLLTSLPQLKIDTPLELVQALYKNKLISSFPNVNICLRIFFSIMVANASGERSLSTLKRVETYLRNAIFQENLKSLAVLSINEDLLNELNITDIIENFASIKSRKQAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNT4</accession>
    <name>A0ABM5KNT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated protein 4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511833.1">
        <property type="nucleotide sequence ID" value="XM_050655876.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655876.1">
        <property type="protein sequence ID" value="XP_050511833.1"/>
        <property type="gene ID" value="LOC114329887"/>
    </dbReference>
    <dbReference type="GeneID" id="114329887"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="787"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="959"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="416"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="731"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1065"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1323" mass="148618" checksum="A655DF9BD2764388" modified="2025-10-08" version="1">MEMTKEKYNPHPREKANILSVLFFGYTYDLFKKGFSKTLEVEDLYNPLKIDRSKVLGDKLQRNWDRQLEKAKRTNSEPSLIKALIQTFWVDYLILAVYGLTTDVVLRFVQPLMLGNLLDHFKPESEVTKNEALIYAGLIVGINVLNFLVLNQYNLGSYHGGMRMRAACCAVIYRKALKLSKTSLGETASGKLVNLLSNDVSRFDLVSLLIHQLWLGPLLSIIVMGLLYQKTGYAGLVGIFSMFVIVPIQTYTGKLSAKYRKQTASKTDERVRLMDEIISGIQVIKMYAWEIPFRKIIRIARRNEIKIITKSAYVRAAFMALNLFTTRLAMFCTLLTVVLMKGPITTSTVFVVMSYFNVLSIAMLLMFTRGVSEIAEGLVAIRRIKSFLLSEEYDPYKTNLRMNGNVKSVDDFSDIVSLKNLTVKWNASFSDNALENINLNISTGQLVGIIGPVGSGKSSLLQTLLGELDITQGEMRVQGQISYASQEPWVFAATVRQNILFGQEYDKERYNEVIKACSLETDFEQFPNGDLTLVGDRGSSLSGGQKARINLARAVYREADVYLLDDPLSAVDIHVSKHLYEKCINGYLASRTRVLVTHQVHYLKDADNIIILNNGRIEHEGTFNVLANSDNVYAKLLTAESENEDKKQDRSKYPRQLSQRSRQSSVSSGISEMSIADTHISINENDFEAEAAEKELEFQVKDLQEQSSKGKVGGSLLLKYILAGSNVLAVLILVILFLGTQLAASGVDYWVSYWVNVEEFRNSTESSNSTTPTFIIPSIELTTNNCLYIYAVLLGSLFVLAMSRSFFFYKLAMLSSQKLHSTFFNNIIGATMRFFDTNPGGRIINRFSKDIGAVDELLPKAILDSSQVLLSMAGSLVLIVIVNPLFLILIGALSLVFGLIRHIYLKSSKNIKRLEGIMRSPVFTHLRATIDGLTTVRAFGAQSILMDEFNHHQDYHSGAWYMFIVSSAAFGFYLDFFCTVFLAVLTFSLLLFGETFNLQGGEVGLAITQATSLAIYLQWGMRQSAEVINQLTSVERVLQYESLEQEPQPVVPQKPAKEWPQKGEITFKDTCLRYFEGGPLVLKHLNLSIQPKEKVGVVGRTGAGKSSLIQALFRLAPIEGTIKIDNIDTKDIRLNDLRLKISIIPQDPVLFSGTLRYNLDPFEEYSDEVLYKAIEDVELRDPANVINRLENRVMDRGSNYSVGQRQLICLARAILKNNKVLMLDEATANVDPQTDALIQKTIRKKFSDCTVITVAHRLNTIMDSDKVLVMDAGQISEFDHPHLLLQKKNGVFYNMVAETGRTTAEQLRKIASDSYQKLNALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRV1</accession>
    <name>A0ABM5KRV1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512917.1">
        <property type="nucleotide sequence ID" value="XM_050656960.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656960.1">
        <property type="protein sequence ID" value="XP_050512917.1"/>
        <property type="gene ID" value="LOC126888604"/>
    </dbReference>
    <dbReference type="GeneID" id="126888604"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="420" mass="48562" checksum="1B5A6680423FE5B0" modified="2025-10-08" version="1">MYGKRARSNNITMPPIFDIYRKPIFDESIRKAEYRTYAPFIKSFNCNDIVEFSINQVDSFFAMSETLLCIKGSLEITGNGGVKLANNVGAFLFDSCMYSESAREMETVRDPGIVSAVRAMTCYTQEDSNYMVMAGWNYPKDPILNAADHSFSIQMPLKHVFNIFNDYPLITCGRQTIRLVRARNDNDCIVITEKQNADKTTTVTTAKINITNIELRVKHIFPNDDIKLELMKSIQQDQPIVIPFRKWELHELPAITRGARREVWAVKTSTSVERPRYVIVFFQTNKRDKITADPTLFDNVNIQSIRLSLNGEYWPNERMQLDFSKTDYNEAYFNYTEFYPSYIHSQQKRPLLDFSAFKNRALFVIDCSKQEESMKASTVDVKLDIEANNGFPDNTKAYCIIIHDCVMEYFPLTEIVKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV07</accession>
    <name>A0ABM5KV07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pericentrin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514020.1">
        <property type="nucleotide sequence ID" value="XM_050658063.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658063.1">
        <property type="protein sequence ID" value="XP_050514020.1"/>
        <property type="gene ID" value="LOC114336636"/>
    </dbReference>
    <dbReference type="GeneID" id="114336636"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028745">
        <property type="entry name" value="AKAP9/Pericentrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44981:SF2">
        <property type="entry name" value="PERICENTRIN-LIKE PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2123"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2487"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="591"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="910"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1336"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1421"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1606"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1797"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1968"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2301"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2123"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2487"/>
            <end position="2508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2572" mass="296752" checksum="489DF16214CB3ABD" modified="2025-10-08" version="1">MEGTSDKNPHEESPSHDDKSETDSVSLTVSLPLGEVKEEENSEDISEHISSNSGSIENDRSFQEIEVYNYQGTYLNEDLRDEVDLSEKQPDILNESLESESSIISLLYLERIEENNVSNLLEDSFQGDASKSDKDLSTVSKEESFNMFQNLDLDDKSLSNIRHSTQPSIEEKNLNASQVQNLDLDDKSLSNIRHITQLSIDEKNLNASHFGLEPVCNEEELSRKLKDYEELVNIQNNTITALTSELDSFREMSNPNTVSTLSTTEYKQLQEEWNGKILEYNGVILIKNDLIQKLTESLEQSSKEKEELMSKIGDFENEISELRETIKIAQMKNQTSDSVQEELNSSIHDQKSLVSEDVSNNLEVEYMTLKENLDMHQHGLLKQLNLKFNEVLEEKISEIKSVHDQEIKTLKESVSLEKDEYESEISRLRALLAEFQAGSTQFMALKDELDLKHSREMEELRTYFEKKCADVEKNYSEEIYSQHSRKMSSSSCSEAELNSDLPFPHVPGPEGDVQTNLNKKDLINLQNELNSIFNKITKCDLDAMTDDDFSNLKREINRSHLSNLLKHSISTGTIKPQIEEHVNAGEKAPKMEDIEARYEEKFNQMKEKYEEELKNLRNLLELAEKQHLSISSTVQEVGSSEEFEINEVIQSYERRLQEQVILAKNDIVAGLEAQIQRLAASEPDSDEWPSELLRIRDRFTEKHEADKMVLNEEHRLELEKLKEEHRKILDEVSQRVLDGAKRRKLRDDESLNKDEMEILKERDILKQRVASMHNLFGELLKYFTQCEDELNNTLVEELLKQGFDKNMSQIDDELNLTRSSPSTSSKTSDSTLNITRVHLTPNFTDLINIIESSSPEEADSKDVSIDVKNELSVCLEKLKQEANAILCLTTKQPVGAILDSKNNNNLEGQITSLTRKLIDETQLKEDLKSELEENQKYIETLEKERERLETELENVIAKENILEEDLTAAKNKIGQLLESGRKEIVSEGYGEAGVHSQSLGDTMNALVDLQEKARNVLSQSRTSADPTLLHLIEELCRVGERIKEESYRERYDLQQQIEAADKKYRTTNKFLEEQAMEREQERDEAQKKIDALLIQLKERDKNKVHSEIVASEVVAFLLGSNNGIFPMMQQIEQLELQLQEKTTAFEASCHKLKDLEDELTEAVEKIKELREIIRNLEIQSETKSVKIQEYLDTINKLQNIIANEHGVGDGKDCDASKDVSDIGELYRHIEHLETELHKLRLNSELAGNEGATKQISTQLYEIEAQVDRKTKELEILHSTASTNCSSPSEDVSARDVVLPKSPKKMEDCEVPLQQLARLREKLIRHSRAEDAAMKRIRDLEMEVFGLKHELEETNGEREFMKKNIQEQLVLISDFQIRLDEQRIRADNIEKQTNTSLELKIYSLQKEVDSLGEKIQQKDRHINNQSNLLAETQQRVRNLENELSSAKEDDLVVDMQKEIDKLVSENAQMKKKIKNEAQMVPNLVGNIISDKNHDMERLRLKLEDTEKLLEGYTSLNIDKKDLQTLSNLKSNGTSLEELFSILDLSQPDLLRRMESRNLSESQSPLLFKREKSDDTLMEPELSSIMGPTSANSVVQMRNSTEISHKKVHFEDIDMECLKKELAELKNQLDAKDKIIKECNERLQELDNLQIKTENQQKSVEDTNNALTAISKSFEEAQMDWQNRERDLGIEIAEKKLKLEDIEKELDLLQQDSKRKDEMCVRLTKEIKDLEKEITKLKNENYLTVENVIKMKNEEMDNLEKELNEKFNVEIEKCKKTISSCCDERGSLLKEMELISTQLADSRSKNSQMEQTLKEHSHEIKKYRKEFENKLLVIESLTREMKEMKEKRAKNRRFTRELEQKLEDQKSSMESLEEEKAAQKCWLLEKETLIKNLQEEADRYKQEIGENMEKLEKEVKENESKIDELTKEKNHLTELLGEREKIIKQMVEDHQQVHLNLVSIKSKIQEPGHIIDLGNKLREEQKKRAELVQEIHNLKVQLMQCKSNEMTTSVDEIADQLKRELDNSIKIDSNIMSAVSDQSLSSISEVQDVEAYKKSLAKEKACKKQLLELVNTLQDRITTLQNDLEKERATLVCNSTEDAQCIEQLRIQLDAALDANEALKRAISERESENEQLEKDLESLKRKNISSASRSESTKYKELPSKESIALNKLQKDHDVLLGEQSKLIGELAGLRQTHLDMTTDYKCTKDLLALEMQRKKNLEGKVYSLQMRERELTENLTQITLEKERVVDEISQEKADLIKQKLELLQRLKSQHSFESSVTVTNDIPDELIKKISELNSAFIENKKLVDMITRISNEKAQVENELEIVRGAVKNSSVQLPSNDLAARADYLFAKTLKLESTKKALVFQKRYLMKYLLTQGVVDVLPDPVTQRAMFRRDFSPKHRFRAAVFVIISISRIKFLVKRWHSGVRIAERINSRHYKQTRRKNDATVVSAHFQVGQPVSNQFFLNAPPAGPTLRNPNQFVQFKEDARETRERLEADRESARSEEFYPERSAPWSGTTPPSKERRSRITIGNAVLNKEDMNPLKAPQLLAQFVERFDQIQEKLGVVLESDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVI7</accession>
    <name>A0ABM5KVI7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM107B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514199.1">
        <property type="nucleotide sequence ID" value="XM_050658242.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514200.1">
        <property type="nucleotide sequence ID" value="XM_050658243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514201.1">
        <property type="nucleotide sequence ID" value="XM_050658244.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658242.1">
        <property type="protein sequence ID" value="XP_050514199.1"/>
        <property type="gene ID" value="LOC126889709"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658243.1">
        <property type="protein sequence ID" value="XP_050514200.1"/>
        <property type="gene ID" value="LOC126889709"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658244.1">
        <property type="protein sequence ID" value="XP_050514201.1"/>
        <property type="gene ID" value="LOC126889709"/>
    </dbReference>
    <dbReference type="GeneID" id="126889709"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF5">
        <property type="entry name" value="FI14214P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20815" checksum="94F374FC2C73CBF4" modified="2025-10-08" version="1">MDVRTFREVGLHDLTKDELDITADSIDHLRTKLESHDIVKLRKFEKLSTMIPDSDRTSEPILNEGGLIIPKKLPNPVKENIERQNLHRELLFNQKIGKNVLNQKSELQRALEKQKDNLARKKLDEHIAEQTPELEKVIADRVKRLQSSHEDKNEDDKVINKELLQMRMNLKTRTDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWR8</accession>
    <name>A0ABM5KWR8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514634.1">
        <property type="nucleotide sequence ID" value="XM_050658677.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658677.1">
        <property type="protein sequence ID" value="XP_050514634.1"/>
        <property type="gene ID" value="LOC126889933"/>
    </dbReference>
    <dbReference type="GeneID" id="126889933"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="168" mass="19402" checksum="CC82BCDDB81F9116" modified="2025-10-08" version="1">MAPTSGARAELRAVLSENSSLNVNFIDDRDDSVADKDYKPSGDDFPSQSSEDELQEPIPRLFKDKEVNSEKKKPTRWRQRNEEHYDRNERKRSRNSGQQYTSKKTKTIISSREIGEENSVLRKGRPAIIELSNIPKKYNEPLKIAKNKLDKIKSLFISRQCTTLFIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXJ5</accession>
    <name>A0ABM5KXJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514916.1">
        <property type="nucleotide sequence ID" value="XM_050658959.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658959.1">
        <property type="protein sequence ID" value="XP_050514916.1"/>
        <property type="gene ID" value="LOC126890112"/>
    </dbReference>
    <dbReference type="GeneID" id="126890112"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="300"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="452" mass="52529" checksum="2FDCD82662C53A81" modified="2025-10-08" version="1">MASKPTCSTSVNKQNKKRWLSVREKQMIKSVYEGLRRRYQDMLKEDVAALCGDLTKVSARTVFRIIKGNKPIQKPIHKGRAKIVLDDSTKSIIRRKVHGFYLRNELPTLKDIQREVNADADDTLNKISMRVLRRTLHEMDFRYVKRSRKSLLIERHELVIWRRKYLQKIRDFRRLNKKIYYTDETWLNEGHTKSKVWQDLNIKSARQAFIEGLSTGLKAPSGKGRRLIITHIGSDSGFLQGGLNVFTSIKTSDYHEDMNSDVFEKWFSSILTLVDPGSVIVMDNAPYHSRRVEKIPTSASRKADIIDWLRSKNIDFDESMLKVQLLDIVREHKSSYIRFAVDEMAREHDITVLRTPPYHCELNPIELIWAKIKKEVAQKNTTYKLKDVKLLLDQAIQNITASNWQSCITHTQKEEDKMWDVDTRVDVLIEPIIITPGEDSSDSELTIGSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXM9</accession>
    <name>A0ABM5KXM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514932.1">
        <property type="nucleotide sequence ID" value="XM_050658975.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658975.1">
        <property type="protein sequence ID" value="XP_050514932.1"/>
        <property type="gene ID" value="LOC126890127"/>
    </dbReference>
    <dbReference type="GeneID" id="126890127"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="123329" checksum="9E26231A35B81D20" modified="2025-10-08" version="1">MDIVKQCKNLLLFIKRIRKIVFDKFTAKDKEIWVKRLTKQIKTCNKERDSGFALNRIVSLEVNINRYEIGNGSSYIKLPESIQKKRACINVKNSDQACFYWAIVSALYPAKAHKELPSSYPWYSTVLKTEDLEAPMPLHQISKFEKLNNISVNVLALELIENNEKSFFTVYPARLTKTVVAKHVNLLLIQNHYFPKLNDYEAPPVDNDNSEIKYHYCHITDMSKLVAGQLNKRKAKLFLCNRCLNYFSTEGKLSEHEKMCADMNNCKMSFPKYDAVSFKNYTYKQTTPFVIYADFECMLEKVTDLQTSCCTKKYQKHIPYSAGYYVKCSYDEKLSFFKSYRGIDCMEWFANELPNLAQSIHSKIKKIIPMQENPSTSKTTRCHICEKCFSPTDIIVKDHDHFTGEFRNFAHQACNLNFKKLFVVPVIFHNMSGYDSHFIISELSKKGDISLLPVNKEKYISFTLNDAVTNIKFRFIDSLRFLGASLDELVSTLNKNDFKICKREFSRLSDDEFKLITKKGVFCYDFIDSWEKLNITDLPPIEAFYNKLNDTNLTDEKYAHAKIVWDTFNIENLGQYSDLYLKTDIVLLADVFETFRKKCFITYGLDPAWYYTMPGYSWDCMLKYVGCNLELLRDVDMILFMEKAIRGGISVCSGRMSEANNKYMPNYDPAQPSKYLMYFDVNNLYGWAMGEPLPYGGFEWMDAKDIDVMSVPDDSPVGYMLQVDLDYPRKLHDLHSDFPFAAEHRKALGSNHTKLMTTLYNKKEYIQSAWLRPYIELNTRLRAAATNDFGRNLYKLANNSVFGKTMENIRKHRIVKLVRSWNGRYGAKNLISSARFHSRKIFNENLVAIELIKSDLVFNKPLYIGMTVLDISKLCMYQFHYDYMLPKLGADKCNLMYMDTDSFIYELYCHDAYEEVIKQDLSKFDTSDYAVDNIYNIPRVNKKVLGVMKDENKGEIMTKFVGLRSKMYTFKVQSGRITKKAKGTKYNIVKNVIKFDDYVNCLNDFKEQTATQHSIRSYSHNVYSIEQTKIALSPYDDKRYLIPNSFRTLPLGHYSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXS4</accession>
    <name>A0ABM5KXS4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505205.1">
        <property type="nucleotide sequence ID" value="XM_050649248.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514993.1">
        <property type="nucleotide sequence ID" value="XM_050659036.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649248.1">
        <property type="protein sequence ID" value="XP_050505205.1"/>
        <property type="gene ID" value="LOC126883596"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659036.1">
        <property type="protein sequence ID" value="XP_050514993.1"/>
        <property type="gene ID" value="LOC126890181"/>
    </dbReference>
    <dbReference type="GeneID" id="126883596"/>
    <dbReference type="GeneID" id="126890181"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="52"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="287" mass="33657" checksum="B5128D84022D599D" modified="2025-10-08" version="1">MESSRLIKWRNEYIEKILQYRSECREIYYLDETWFDSHETIDKAWTNGLSKCQIDVPHSKGKRICILHCGGQHGWVNDALLLSSKSIKDSSLDYHQDIEGTLFESWFENTLLPNLKANSVIVMDNASYHSRCIKKIPTKQSRKDEIQEFLIAEDLYFEDHYTKDQLIQVLHTKVVTKEHIVDKLATNNGHTVLRLPPYYCVLNPIELLWAQLKNHIRRNNTSPKDAQSVVELIKTEFKNISAQNWQNAIEHVKKIEKDYMKNVPALKKIIINLDESDEENDNDDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYA8</accession>
    <name>A0ABM5KYA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515178.1">
        <property type="nucleotide sequence ID" value="XM_050659221.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659221.1">
        <property type="protein sequence ID" value="XP_050515178.1"/>
        <property type="gene ID" value="LOC126890351"/>
    </dbReference>
    <dbReference type="GeneID" id="126890351"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF17">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="452" mass="51451" checksum="C3CD3724DAEBB48A" modified="2025-10-08" version="1">MKNEKKNVECLANYGLAKQIESNRAKLKSIVSSILFSALHDLPLRGHTNEDAVFNNLLHFRKEAGDSVLEDHLKNAPKNAMYISHRTQNEIIDLCATVLRDELVTKINDNEIFSILADETMDITGTEQLSLGVRYFDKSENCIREDFLDFTPLKSLDAEHIANAITLTLTNWGLNLENAVGQGYDGGSTMAGEITGVHKRITEKYPKALYFHCASHRLNLIVNNLNDIPQIRNTTGTVKEVITFFRQNGQRRAIVGTLQKLCETRWTEKYKAIRKFSEQFVSIAEALQTLSTEGNRDTRQKAFQLHCAVTNTAFVICLHVIAKYSAKLEIVTQMLQGVSVDILKISKHIQNVTELFSSDRQNGEKEFDNIMANVEKTANKLGIELTCPRVAARQVHRRNHSTQTINEYYRKSIFLPYLDSLVQSLKDRFSDRNKPSFEIFNLHPKIMKDLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYL5</accession>
    <name>A0ABM5KYL5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515272.1">
        <property type="nucleotide sequence ID" value="XM_050659315.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515273.1">
        <property type="nucleotide sequence ID" value="XM_050659316.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659315.1">
        <property type="protein sequence ID" value="XP_050515272.1"/>
        <property type="gene ID" value="LOC126890411"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659316.1">
        <property type="protein sequence ID" value="XP_050515273.1"/>
        <property type="gene ID" value="LOC126890411"/>
    </dbReference>
    <dbReference type="GeneID" id="126890411"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="613" mass="68045" checksum="B07B3C31ABEE7CEF" modified="2025-10-08" version="1">MAECGCTDPGYYGPYLGNNCGAGSFIVFMSLVDAIIRNTCDISDVCGRVQPIEEPDFSYDFIVIGGGSGGSAVTGRLLEHKKSRVLLIEAGVDEPETYQVPGLILKYYNNPIVDWSYRTSDEPVACRATNGSCNCLRAKMLGGCSSINGMMFTRGTPPDFDKRWSGEGIKGWTWNDVLPFFRKFEHNLQPSEYDSHYHGYSGPVAVSDQYYVHDLSKSILKGAAEAGFPISKDINGKDYTGFANSQSYIKDGVRVSMAKAYLRPQRNNPHLHVMLNSTVTRILFDGHKKAYAVEFLYNNQTFTVKAKKEIILAAGTINSPKLLLQSGVGPKDALDAVGIKQIHNLPGVGQNLTNHVSFKVNYWINSTVDTRIITWKSLEDYLNDRTGPLSTIGITVTCRLPSKYTTADDPDIQMFFSLSQNTCSPDGAVDEPVDPTNPQKPQHVAISVVNLHTKSRGRITLKSKDPLAPPHLVGNYLTVKEDEDRIIDGIRLAQRLVNSTTLKDTVQFVFDNVTQGTCADQYTWDSDDYWRCAIRYNTFAENHQSSTLRMGSTDDEWSVVDEELRVIGLHNLRVADASAMPVVTSSNTNAPIVMLAERCADFIHHRWGHYGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ59</accession>
    <name>A0ABM5KZ59_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Endoplasmic reticulum membrane</location>
            <topology evidence="2 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515472.1">
        <property type="nucleotide sequence ID" value="XM_050659515.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659515.1">
        <property type="protein sequence ID" value="XP_050515472.1"/>
        <property type="gene ID" value="LOC126890518"/>
    </dbReference>
    <dbReference type="GeneID" id="126890518"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044986382" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="460" mass="52805" checksum="CEF8BA51CF7BCB91" modified="2025-10-08" version="1">MLKLITFIFIIVTVNAAERINNNLIYKNVDRTIDLTSQLVKITSTITLENAGADPIKNFLLAEQPNLVGQIAFKGAKDSAKQDLNVLTAQVENQSDKRFHKVILRQNLEPGRTATVVVEEILIKSLIPYPNSISQKEKQLVRYFGNHYIYTPYTVVKQKTDVTLSSRSIENYSKLKPVTQTDSTIHYGPYGEIAPFAVDELIVHYENNAPFLTVVHLDRTIEISHWGNIAVEEQIEIKHTGATLKGPFSRYDYQRDTSSTHHSIKSYTTVLPATAHSIYYRDSNGNISTSAVKHRKDWIELELRPRFPLFGGWQSSYTLGYSVPSYQYLFKAENGDNVLAMRLIDHVFDDMYVEEVVTNVVLPVGVTDIKIRPPYDVERLSDDVTYKYLDNLGRKVIRLKKRDLIEQHIQDLEITYKWQPRLLLHEPLLLSLALFILFVAVIIWVRLDFSLAVPEHSKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L056</accession>
    <name>A0ABM5L056_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 11-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515821.1">
        <property type="nucleotide sequence ID" value="XM_050659864.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659864.1">
        <property type="protein sequence ID" value="XP_050515821.1"/>
        <property type="gene ID" value="LOC126890687"/>
    </dbReference>
    <dbReference type="GeneID" id="126890687"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38725" checksum="8FDF1294A61DA947" modified="2025-10-08" version="1">MYDRFYFLVRKMSIFVIILLSLAICLIIFLLVVFKFGYVKCESNVCLIGKVALVTGGSSGIGYQIALQLASRACKVIIADRVINDDIKQSIIKETHNPNIILEYADFTSFKSVRDLVEKIKSSEEKLDILFNNVGIGKAPEHPSEDGVNMTMQVNHYSPFLLTHLLVGLLRKSSDGRIVFTSSVASFFHTTTIDSVTENEIKLSKYRMNDYTCGKLCTVVASDIFAEKLKKYNITCNTYHPGVARSTFFKNCYENLDHFSFTDWWAYGLIVFLRIFVGVSPRQASQPAIMLAVSKEFKNVTGTFYGKYFPDLKPLGAHNKVFCKKIWDVSEKIVKLSPEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1Q5</accession>
    <name>A0ABM5L1Q5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050516372.1">
        <property type="nucleotide sequence ID" value="XM_050660415.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660415.1">
        <property type="protein sequence ID" value="XP_050516372.1"/>
        <property type="gene ID" value="LOC126891233"/>
    </dbReference>
    <dbReference type="GeneID" id="126891233"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="96"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="225" mass="25139" checksum="28ADF110A7844FB4" modified="2025-10-08" version="1">MVRNDLAGDSRGGHVPPHIKVLCAIRTWARREIQDDAADIIGISQPTVSLVCKQVALALVVHRAQWIKMPQNDLEQNRVIAGFYGICGFRQVVGAIDCTHIRIPKVGGNIGQYYINRKGYSSINVQVVANANLEIMDIVAHWRGSTHDSRIFNECRLKRRFEQSEFKGRLLGDSALAILNNIAIHHRDMIENIDQPGNEDILVIPAINNNIRGNAARAAFINDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1T2</accession>
    <name>A0ABM5L1T2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516395.1">
        <property type="nucleotide sequence ID" value="XM_050660438.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660438.1">
        <property type="protein sequence ID" value="XP_050516395.1"/>
        <property type="gene ID" value="LOC126891257"/>
    </dbReference>
    <dbReference type="GeneID" id="126891257"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="190" mass="22720" checksum="BEE8D2D287EB1F6B" modified="2025-10-08" version="1">MADGRRSVSKTTQEGEEQKQEKSELEKFMELILTKMEENNKKMRKKLDENSQKVEQKLEENNQSLEQRLGEKLEITLEKMEDKLEENSQKTEENNQSLEQRLGEKLEITLEKMEEKLEENSQKVEQKLEENNRKAEENSQRLQKKLEQTSKRLEDQIEQRINKSIGEVKMLYEEMMNKHETLETKLTSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2I0</accession>
    <name>A0ABM5L2I0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516651.1">
        <property type="nucleotide sequence ID" value="XM_050660694.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660694.1">
        <property type="protein sequence ID" value="XP_050516651.1"/>
        <property type="gene ID" value="LOC126891517"/>
    </dbReference>
    <dbReference type="GeneID" id="126891517"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17627" checksum="C89BF7EEAA3CB278" modified="2025-10-08" version="1">MRCAVGCCNSDNKDKTLRFHTFPKDSVARKLWIIACCRQDNLNCNTARICSKHFKTEDFQRNLQHELLNYESKKGPKLKPEAVPTLYLPKTKSATLSAIQKKRVQRAEHRESKNIVEQLLTTSESTTQLQVRVQEEQCSQADIKDYYLHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2Q0</accession>
    <name>A0ABM5L2Q0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516717.1">
        <property type="nucleotide sequence ID" value="XM_050660760.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660760.1">
        <property type="protein sequence ID" value="XP_050516717.1"/>
        <property type="gene ID" value="LOC126891584"/>
    </dbReference>
    <dbReference type="GeneID" id="126891584"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="427" mass="48835" checksum="0B9D21969A9D57AC" modified="2025-10-08" version="1">MLFEKQLLKRKKEVFELRQVASSIINVLKLIGKQGLAIRGQVESAYSFDDPSVNHGNFLEIIFLLCNYDKNLEAHINKAMEISKTALEAHKASSEKQRYRGRGSQLALLSKTTINKFINIIKELIQKDIVEEIKQAIYYSVQMDSTTDVSGFDQCIITLRYVNRTEVKERIISLKRVHSATGENLFKTILETFLFVNLDVKNCIADSFDGAANMSGEYNGVSSKFKQLQPNHIHTWCEAHTLNLVLSDTAECVTTSISFFSLLQQTHVFIKDSHKRLEIYLKQNPNFRLTAIGATRWRSKSDSTCKIFGHFDKWSKWVKDDISSCKCVYLELIISLSMIANSPDFNSKVRNEANSLLQKFTSFEIILTAMMFLLIFKTTTPLSNYLQTKNLDYVQAWHMVASAQTKLEDIRNNFPTVLDAAQNFAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L418</accession>
    <name>A0ABM5L418_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517191.1">
        <property type="nucleotide sequence ID" value="XM_050661234.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661234.1">
        <property type="protein sequence ID" value="XP_050517191.1"/>
        <property type="gene ID" value="LOC126891893"/>
    </dbReference>
    <dbReference type="GeneID" id="126891893"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="439" mass="48680" checksum="D8D02A27D694A6E8" modified="2025-10-08" version="1">MAASRRKQDEKNLKTLRELGVLLANKYCFDCNQRGPTYVNVTIGSFVCTKCSGMLRGITPPHRVKSISMATFTNEEIDLLKNRGNDYCRQVWLGLYEGTPIVSPGDETSIKEFMVEKYERRRYYLDPVNVTVNNIKPAEETKTPKVNGIQIQPKQRQRSEISRNNSVENNNLINNINNNNSSNMNGFVADFDKADIFMGASTTTLNGSSTSLNGPAARLQPPQNSFANFDNNPVFNNVNVLQNSSTDLQNPSPFNYINNSWDQLTPVAPLNNPLNSTMSVRPTEDRYAALKDLDNEFKSQKNGSLDWSNSSTGSSIPTGSVNSSPSPQPSVFGSHNPGQFMGTFPLNQDNTSNLVSNPFNNNDLTSDINWPNLNPPLQQKLVNPFRDIMKTNGYMQDFHPVGAFPPQAVPFAVNGTNGWTQNPFKVGGTNGMNSNNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA39</accession>
    <name>A0ABM5LA39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">COUP transcription factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519303.1">
        <property type="nucleotide sequence ID" value="XM_050663346.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663346.1">
        <property type="protein sequence ID" value="XP_050519303.1"/>
        <property type="gene ID" value="LOC114333023"/>
    </dbReference>
    <dbReference type="GeneID" id="114333023"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06958">
        <property type="entry name" value="NR_DBD_COUP_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06948">
        <property type="entry name" value="NR_LBD_COUP-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="192"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47473" checksum="225C17BFD494FA10" modified="2025-10-08" version="1">MALVASSWRETSLGNPVSLNSLPNGLNPLPQTSTLTPLPTNINPINLETSDPSLINRQTPSQNSQNSNNSVDKNQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCMKMGMRREVSGSAQKSAVQRGRVPPSQPSLPGLPNQFLNSTDSMNTSLSNHTYLSSYISLLLRAEPYPTSRYGQCLQSNNIMGIDNICELAARLLFSAVEWARNIPFFPDLQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLIAAAGLHASPMCADRVVQFMDHIRIFQEQVEKLKVLHVDSAEYSCLKAIVLFTTDACGLSDIAHIESIQEKSQCALEEYCRSQYPNQPTRFGKLLLRLPSLRTVSSAVIEQLFFVRLVGKTPIETLIRDMLLSGSSFSWPYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA40</accession>
    <name>A0ABM5LA40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519309.1">
        <property type="nucleotide sequence ID" value="XM_050663352.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663352.1">
        <property type="protein sequence ID" value="XP_050519309.1"/>
        <property type="gene ID" value="LOC126893313"/>
    </dbReference>
    <dbReference type="GeneID" id="126893313"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="57340" checksum="CE6EBFC430EE8412" modified="2025-10-08" version="1">MKDFIANNCRLCKKVFCCKTCRENHEIEVHKVFPHCDICIFGQTRISSMSQVVLEHIKAAHWPLNCLVCKILFESINDLFQHTRCPLVNNSQKSPYTPHNSGISEKACTPYIPGKLDYGNKVNILTNLATSTPMQRDQANIALGRIQEVIITPVDCSVEKNGDTVEHNSLSLKRKVTFSDTPITESLSKKLKNSSAFEGRVICTQFFTAVGLSGGSAYFSATENQSGIMEESTKDEKSALVLHEQKEKEEKEKPSVKQANIIIHKEEKVVWISTTEVCSSFEEESSLDFHISNNQFFTPMVPKKKINIVAPSSMVKNKEMNVRLEGPVQISSTPNNSIIPIKSAPTMRDIFHNRPSTSKGGSENWNSADVHSNDKFGFTESKEDDISLDNSMPARLWSSVTNLVKNVLHGLSTTLADSTSSTPGSLKRFISDQDLDQMPNAKRYKVTDVRCRNTIRDMTPINKYMQSYRLQRSRELKIKIANSMTIKTFADKATQTDESIFTDGQTSVEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAC5</accession>
    <name>A0ABM5LAC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519387.1">
        <property type="nucleotide sequence ID" value="XM_050663430.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663430.1">
        <property type="protein sequence ID" value="XP_050519387.1"/>
        <property type="gene ID" value="LOC126893346"/>
    </dbReference>
    <dbReference type="GeneID" id="126893346"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="183"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="430" mass="49397" checksum="E76B4C38B4F508AF" modified="2025-10-08" version="1">MFFSQEDFFILSCGWLILKSLEKKRRRKRKHRYWVRSLLSRRVNDGAAQLMNDIQNDDFGLHGELRSSFHNFVRMSSSDFEELITLIGGKIAKLNTNFRDSISIKDRLAVTLRFLASGDSYQSLMYLCKISVPSISRIIPEVCDALNEVLNDYIKVPTNSAQWQKLANDYNTSWNFPMCVGSMDGKHVVMQSPKYSGSEFFNYKGTFSIVLFAVVDANYNFTYVYIGCQGRISDGGVFKNTGFAKSLSKEMLNLPENASLPEREKRVPYVFVADDAFPLSPNILKPFSGHQDRGSMQRIFNYRLSRARRVVENVFGILASVFRIFRKPILLEPPKVEKIVQTCVLLHNYLRRNTESKNTYTPPGSFDVEDIDSGTIRNGSWRNESQPTASMLPLKPVARKSLQEAQNIRNEYCEYFISDQGQVPWQLKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAG9</accession>
    <name>A0ABM5LAG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaoptin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519432.1">
        <property type="nucleotide sequence ID" value="XM_050663475.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663475.1">
        <property type="protein sequence ID" value="XP_050519432.1"/>
        <property type="gene ID" value="LOC114327989"/>
    </dbReference>
    <dbReference type="GeneID" id="114327989"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF211">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1136" mass="130951" checksum="5A103492F93AA9E3" modified="2025-10-08" version="1">MDTSKHIYNKTGLNLVEDDLRVRNLKTKAKDKKNNQISSLDGEWSHMKNTVATLFLGENDVTEIPTDSLDHTSENLHGLRQFKSLIWLNLDGNRILKIHTHSLPPALQTFSVSHNLIESFPIDLVGTLPQLQWLYLRGNHIKILPEHTFFRRLWMEKIDLGENFLKSLPKTPFNNTICIRDLNLASNDFRTLTAESFSGLETRRIILSYNLLENLDLRAFSGLEDTLEYLDFDHNNLQQIPKAVSELRTLKYLYLSSNLLIDIPENAFENFCPTLKALSLSGNRLTKVPWKSLQNCSKISHFNVAFNEIDDISENDFSWGTSIKSLNMGNNHLTGLHGNIFKYLENLKELSLSFNPLRYIDREAFSNLKQLESLELSFSLNPDIDIEGIFVPLERLHWLSIDNNNLHTVPENLLTSLRQLKYINLESNKLHFIPKGFFKNNVELQDIRLSNNELRTIETETFYHLSNLQSISLASNKIKHIQRESFAHLPNLSKIILSDNYLIHVSHDSFSNLPAISKIDLQNNFLKEISFKFITNITYPISVNLTKNRITFCTSDSRILNIETLDMSFNNLENIPKCLEHTASLKKLILQSNVINSLDHNAFMHLTSLEQLHLKSNNILLVSKKAFFGLQNLQILDLSKNFISQLHTNQFVNMPKLRILNLRENRLSYLPRDIFSNTLLEMLDLGLNSFTVVPTTSISDVGMTLRHLSMRSNNIEHIDITTFPDIPSLQYLDLSNNKLTILPDNVFTSLGLLQYLDLSFNPLRSNFKELFHYAQNLKRLDLSNTWIMHTPYFPLPNLVYLNLSHNLIEIINKNSVQQLLKLKSLDISFNNLEEVPSHLWSYLPNLKILNLSNNPIKELVVDSFVGLQNLQELTLLNLKHIKKFEGHSISQLRVLNKLTIESWPRLDHFADQFCTLLSNFDQLRILKIYFYENKLDDQLLCITNRKIRELDISGKNLKFVDKDAFARFVRNPDLLLKIHNTLIEDLPSGLFANMYKISYLKIDLRYNMLSHLSPDIFYGNVSGWRTVGTTVVAGGLVLSNNPFRCGCHLAWLGHWFRRWIRESVQAHDVPPETAIKMHQLVKEATCIDSTSGKVVPIVHLPPEDMSCHASALSKATKINKTSFVLVLFVVQFEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYW7</accession>
    <name>A0A6P7EYW7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U7 snRNA-associated Sm-like protein LSm11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324525</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128186.1">
        <property type="nucleotide sequence ID" value="XM_028272385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYW7"/>
    <dbReference type="FunCoup" id="A0A6P7EYW7">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272385.2">
        <property type="protein sequence ID" value="XP_028128186.1"/>
        <property type="gene ID" value="LOC114324525"/>
    </dbReference>
    <dbReference type="GeneID" id="114324525"/>
    <dbReference type="KEGG" id="dvv:114324525"/>
    <dbReference type="CTD" id="134353"/>
    <dbReference type="InParanoid" id="A0A6P7EYW7"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005683">
        <property type="term" value="C:U7 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071209">
        <property type="term" value="F:U7 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039267">
        <property type="entry name" value="Lsm11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415:SF1">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="116"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028128186.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28749" checksum="B5D73B0C7A9BE6B4" modified="2020-12-02" version="1">MSETSTDEENSKKEPYNPQLDFSSDQFNPLLALNTPNLSIPCTSAKRYDNLSAYESAINKANNPEQYAKKSEKIKQDTETIVRRWKEHQLPVPTTKSIRYSRNILSKMEKTEGPLKLLKKCVDEKLQIKVYTRNDREVRGYCLAHIVAFDKHFNMALEGVTEVWTRRKKQKKPAFASIEPVRKSKFQRTFKFPKIGVFPDENNKKLVTCVRHVDQLVMRGEHVVLVSVVNEENTDKTEAATKSKDVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F058</accession>
    <name>A0A6P7F058_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAX3- and PAX7-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114324934</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128656.1">
        <property type="nucleotide sequence ID" value="XM_028272855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F058"/>
    <dbReference type="FunCoup" id="A0A6P7F058">
        <property type="interactions" value="2062"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272855.2">
        <property type="protein sequence ID" value="XP_028128656.1"/>
        <property type="gene ID" value="LOC114324934"/>
    </dbReference>
    <dbReference type="GeneID" id="114324934"/>
    <dbReference type="KEGG" id="dvv:114324934"/>
    <dbReference type="InParanoid" id="A0A6P7F058"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="6">
        <location>
            <begin position="495"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028128656.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="90214" checksum="3CC4008F65541368" modified="2020-12-02" version="1">MSLFRKPKKTIQRRVFTENDDEDDDATQPMEVCQSIPVEKKSKKKDKSSKTPKTLLSFDEEEEGEVFQVKKSSHSKKVLRMFEKEKKKKESKQEKEEIKSKEKTEIVTDDFVLVVNASHKKPPTPPLILSGRDALCAGKDDLSSEEDEPQNHKFNKPDNFKRILESGAIPDAAMIHAARKRRQRARELGDFIPTEEEEPEDKGRLLREDEHEGSDEERIDMEINLNLRDQERRREQFLAAQESDHEVLEWEDQQIRKGVTGAAMEAAREMFYPVEPPSPPRISAQVPFIEPGIPRTPQMIAEKLREQYEKVNQSRANHEAQLEKTRNDIQEAMNELDELKIKAPDAAERFRFYQELRGYITDLVECLDEKVGVISSLEQRALDLMARKSEWLIERRRQDVRDQTEEATNKGMIIKKGLEDEEKQRRAAEREGRRTRRRRTRESAGVPKHVEGMSSDDEISQQDNLVFDKEREQIQSEIQEVFEDVVEEYSSAASILIRFEQWRTSDISAYNEAYATICLPKVVSPLVRLNLVFWDPLNETSELEKLEWYRTLALYGLHDDETEESLSKDPDISLLPTVIEKLIIPKLTQLVDRCWDPLSSSQTLRLVGIISRYIRRFPSLGPSSKSLNNLFNAILHKMKRSLEHDVFIPITPKLVDNKSQFFQRQFASGLKLLKNITSWQGILNDNLLKELALRSLLDRYLLTGLKFCSLIDAVQKVKLISLILPRIWLQSSTPEFKNFSNAIVNLHQQLDKNNPLHLEPIETITNIMKTLRSFMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F1Z4</accession>
    <name>A0A6P7F1Z4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Low-density lipoprotein receptor-related protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114325502</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129361.1">
        <property type="nucleotide sequence ID" value="XM_028273560.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F1Z4">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273560.2">
        <property type="protein sequence ID" value="XP_028129361.1"/>
        <property type="gene ID" value="LOC114325502"/>
    </dbReference>
    <dbReference type="GeneID" id="114325502"/>
    <dbReference type="KEGG" id="dvv:114325502"/>
    <dbReference type="CTD" id="44279"/>
    <dbReference type="InParanoid" id="A0A6P7F1Z4"/>
    <dbReference type="OrthoDB" id="72419at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDLR_class-A_CS"/>
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    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF41">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="20"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0675">Receptor</keyword>
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    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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            <begin position="24"/>
            <end position="1589"/>
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        <location>
            <begin position="1382"/>
            <end position="1401"/>
        </location>
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            <begin position="118"/>
            <end position="160"/>
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            <end position="206"/>
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            <begin position="604"/>
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            <begin position="1453"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3C8</accession>
    <name>A0A6P7F3C8_DIAVI</name>
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        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114325925 isoform X2</fullName>
        </submittedName>
    </protein>
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        <name evidence="4 5" type="primary">LOC114325925</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028129877.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14013" checksum="7C0D6B7CC1A42976" modified="2020-12-02" version="1">MKFYLSLATIAMLAASVKCTQLLGNYNLVSPPFVPQVYNNHAGSPGIVSALSQRQDLAHPAVVQNSIAESQLPPELLNPFYKNPVIASALARESWFTNKEFPIRNREAEKISREEIYKIISRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F750</accession>
    <name>A0A6P7F750_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114326478</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC114326478</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028274871.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050647376.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050503333.1"/>
        <property type="gene ID" value="LOC114326478"/>
    </dbReference>
    <dbReference type="GeneID" id="114326478"/>
    <dbReference type="KEGG" id="dvv:114326478"/>
    <dbReference type="InParanoid" id="A0A6P7F750"/>
    <dbReference type="OrthoDB" id="6791283at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028130672.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29886" checksum="A9B2BD8297B31DE3" modified="2020-12-02" version="1">MSDSEPEEVNRYKKFKHCSAISEDERKLLLQCVSKFQLHKYYEYTPAIKAEINEKWIQFSEILKDKGYDRATEKLGNQYLSLKKQAIRSISIFYGHRRGEKPTKIDYLFAYLFPKYFEKVGLDMNELMADAKVNAKEILESLASTEDQECATILEDTASLEYSNKLKPQMNLKRSHSNKAEGPANKMTKVHEDEATLEPLINNNNSLKDYINALKAKLLDIENKIKEKDHQLELKNLEISRLNDLHAKNLEEMKFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F778</accession>
    <name>A0A6P7F778_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114327049</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131346.1">
        <property type="nucleotide sequence ID" value="XM_028275545.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500077.1">
        <property type="nucleotide sequence ID" value="XM_050644120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F778"/>
    <dbReference type="FunCoup" id="A0A6P7F778">
        <property type="interactions" value="1175"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644120.1">
        <property type="protein sequence ID" value="XP_050500077.1"/>
        <property type="gene ID" value="LOC114327049"/>
    </dbReference>
    <dbReference type="GeneID" id="114327049"/>
    <dbReference type="KEGG" id="dvv:114327049"/>
    <dbReference type="CTD" id="6124"/>
    <dbReference type="InParanoid" id="A0A6P7F778"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="278"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028131346.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46024" checksum="F70AC6D1F322B346" modified="2020-12-02" version="1">MSLSTARPLVSVYNEKSEEVKGSNISLPAVFKAPIRPDVVNFVHQQVSMNHRQPYSVSDKAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKPWRRWHRRVNINQRRYALASAVAASGVPALVMSKGHVIDQIPELPLVVSDKVQEMSKTKQAVQFLRRIKAWADIQKVYKSQRFRAGKGKMRNRRRIQRKGPLVVYYKDQGLRRAFRNIPGIDLISVQKLNLLKLAPGGHVGRFVIWTESAFQRLDKLFGTWKTASLEKKGYNLPQPKMANTDLSRLLKADEIKAVLRAPQKKVVRRVRRLNPLTNAKAMLKLNPYAAVLKREAILKNQKRQLNREELLAKKRGITVSADNVVIRSRKLQERRRAQILKDKKSKPKKAKKAPAKAAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7B8</accession>
    <name>A0A6P7F7B8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shootin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325447</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129325.1">
        <property type="nucleotide sequence ID" value="XM_028273524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7B8"/>
    <dbReference type="FunCoup" id="A0A6P7F7B8">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273524.2">
        <property type="protein sequence ID" value="XP_028129325.1"/>
        <property type="gene ID" value="LOC114325447"/>
    </dbReference>
    <dbReference type="GeneID" id="114325447"/>
    <dbReference type="KEGG" id="dvv:114325447"/>
    <dbReference type="InParanoid" id="A0A6P7F7B8"/>
    <dbReference type="OrthoDB" id="6429491at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044295">
        <property type="term" value="C:axonal growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001224">
        <property type="term" value="P:positive regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024849">
        <property type="entry name" value="Shootin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46606:SF5">
        <property type="entry name" value="SHOOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129325.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57927" checksum="279F1DD294105CCF" modified="2020-12-02" version="1">MSVINKHPVPSKLSTNGTSNIPLRRTMQRQISSPISSKIPVTEGQAVRWKQKFEEAEEKRKALLTEKEKALRNLTDIEKKYLNLQIKHDHLETELFEKNEEFTKLSTASKNLYKEYETLKNQYETETRAMTGALKDASQWYRENKELKRKTLLLMDKDTVDEGVDAGEGESNSETDIENLNKTIKQLSTEIAELQTEVDGLKQTEFQTSEDNIRLTEDLESERQKNIKLELELFELKKEHEQTLRVMEMMKKEMKELQMLEEEHRTNLTNLKKESDAHKREKNVLKHQSTLILQGLNESEGSDNYLLLLQEIEDLKRTLEDERNKHDEEVTILQERLEDQDNNAQIEVLEERLKLVESELQTATERAERAEEKLKAPPAPPPPPPPPLPPMLPPLSLPASDPPAVPLRRRRSKVALSDLAESIGVQENTQSDKKPAAAPGVNEDIINAIKAGQFTLRKAKKEKEKQEQKEQPKAVSELLNILGSLRRAPKKRQSQFYGDLTVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8C2</accession>
    <name>A0A6P7F8C2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Krueppel-like factor luna isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325983</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129942.2">
        <property type="nucleotide sequence ID" value="XM_028274141.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129943.1">
        <property type="nucleotide sequence ID" value="XM_028274142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8C2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274141.2">
        <property type="protein sequence ID" value="XP_028129942.2"/>
        <property type="gene ID" value="LOC114325983"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274142.2">
        <property type="protein sequence ID" value="XP_028129943.1"/>
        <property type="gene ID" value="LOC114325983"/>
    </dbReference>
    <dbReference type="GeneID" id="114325983"/>
    <dbReference type="KEGG" id="dvv:114325983"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF150">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR LUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="215"/>
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            <taxon>Diabroticites</taxon>
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        <source>
            <dbReference type="RefSeq" id="XP_028131127.1"/>
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</entry>
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    <accession>A0A6P7FA38</accession>
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        <submittedName>
            <fullName evidence="9 10">Serine/arginine repetitive matrix protein 2-like isoform X1</fullName>
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        <name evidence="9 10" type="primary">LOC114326239</name>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Diabroticina</taxon>
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        <scope>IDENTIFICATION</scope>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="956"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028130340.1"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119240" checksum="4CA8B4A9ABBE786B" modified="2020-12-02" version="1">MDSEDSREASSGSGSEDDQGRISRASKKSAGRDSYKSRSSSRSSSAGSRAHSASSQSSAGSRSRPPSPEADRLQSRSNKSRSPDSRSSRSRSPNEVSAAPRSQSPNPRSPKVRSKEKQGPRSPSSSSSSSSEDEEPKSPEPERPVSGGPRSPPSSPPNDYPKSPSPAPDMLSHPRSPSPNQVRSPLPNHPLSSPPNHPKSPPMNHPQSPSPNHPRSPSPNHHRSPSPNHPRSPSPNHPRFPSPNHPRSPSPNHPRSPSPNHPRSPSPNHPRSPSPQSSSRSSSQESHGHKSDHCVNGEVKVRSPRSSGSPRQRRSPSPQSSVRSSSPDSPERASNKLQDRNIPPKDDGPLRQLSKRSRSSSASSSSQESPDRYVRKKHPNNDNASVKSDSSSKSSRQSRKSASSRGSRRNRTRRKRASSDSSDSSIDSSSRKNKHISKTDTQAEEISDGDIESENEKGRSKQNAPKQEINISHDDLSDVSDLEDSIGGPSENDDAKSTKSEKKVNSTEYIEEQPLPASPEPKKVSEKQTRPEEGEEQLDFEAEDGECEVEIIKDKDETEERSKNDETEKTDEKEKEKKEEKQREELEEGEVTDEDDVRPEETEPRPVCRFFSRGQCTWGASCRFLHPGVTDKGNYTMFEMIRPVVPGEFRDERAYGKVEPPVVESAWERGLRTAKEMLRKSVKRKEQDIDFEEKKMNLSLAQEEFDKENGYYGRASPEPRYVRHVEYPARPPPEEYYGRRQVVYEQQDYMPPPRERARPYRELPPHRMPDYYSNKYNEEEAPPHSSGSTGKRSNKPKREVIVQRVESERPSSGRGDEWQDPWMRSKDQGRRKEAPGRKRSYSTGSSYSSSSSSSSSDSSRSSYASRRRARGRRSRSRKGRPVSPSVIVSERKAANERAALMNPPAPKRRAASPGMMRLSAAANPPAPLRDEQFSRSRSKLAVAAALARVRGRRASRSSSGSSSGSSSDSDSSDSSSSSSRDNSPPSRGPVDLVKAMDALKGSALEKKQIKLNLKNPVGPKKPENPRSAESSQAKKRPANSPPPGDPKSKKATSRREELLKQLKAVEDAIAKKRSKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB05</accession>
    <name>A0A6P7FB05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Importin-11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ran-binding protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114328419</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with UBE2E3 and RPL12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133069.1">
        <property type="nucleotide sequence ID" value="XM_028277268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB05"/>
    <dbReference type="FunCoup" id="A0A6P7FB05">
        <property type="interactions" value="1698"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656691.1">
        <property type="protein sequence ID" value="XP_050512648.1"/>
        <property type="gene ID" value="LOC126888436"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FB05"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000116">
        <property type="entry name" value="importin-11 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="14">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028133069.1"/>
        </source>
    </evidence>
    <sequence length="977" mass="112412" checksum="B03A28F243BEA327" modified="2020-12-02" version="1">MNIDSTNMMVLEVLQGAASQNPEVLKPAEAKLKEWETQPGFYTTLFNVISTHSIDVNVRWIAVLYMKNGLDKYWRKNAPNAIAVEEKNTIKQGLISDFVEPIYQIAIQRAVLVAKIARMDCPKEWPELFPTLLTAVESSDSLVQHRSLLTLHHVVKAISSKRLAGDRRIFYEFTLNIYNFILNLWNNYTEAFVRDISENASAESITVNLEKALLTLRILRKLSVFGFYKPHESESCMSFLKILFEKAKVVLQCRKQLKGKGIYVLELCEKFIIHLTKVLLSILDTHPFSFIDFIQLSLEFTFYYLFTDEGINFVFERFVIQCFNLIKNILLCVEYKSVKSDLNKYPDTVKATKIKQEFFQPDRVADMCRKLIGHYFILTQDELDTWDSDPEDFSNDESGDSWKYSLRPSTDTVFVTIFHEYRDTLTPVVLELVAETNVLVSPNDMQAILKKDAVYNAVGLCAFDLYDAIDFDAWFTNTLYQELKVKDNNYRVIRRRVTALIGRWTGIKLSSELRPVLYECINNLLDPKEDMAVRLTAASTLRYAIDDFEFNCDQFKDYMFTSFNLLFTLLKEARECETKMQVLNVMTLLLEIMGGVLQLELDSLVQYLPYLWQESEEHNMLRCAIVATLVQLVKALKGVKPELNPFLLPIIQLGTDVSQSAIVYLLEDCLNLWMTVLEYSTSMSEPLLQLFNCMGSLLEYSTENLRHCLLISLVHLLLAPELVMRTQGVQLMQVCDGLMGDLKNEGIVMLMRLVETFLRASPTLGAETTLPILPRIFEKIYGGESYPMLLSMYLCVMSRVLLSSHEVFTRVLSKLAQSSTETEQVIMSKLLDMWLDKMRHVSQPDHRKLLGLALTNLLTTQSTPVFERFGLVMLNILEALNDITRTEDNGAIVDSLVLTEGQSPSDFEDEECYYETDHNQRRKQLILSDPVHTIVLKDYLQSQLVQLKTQVGEQQYGFLLQTVDQDTLSQLKDYIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDW8</accession>
    <name>A0A6P7FDW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114329076</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028133891.1">
        <property type="nucleotide sequence ID" value="XM_028278090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDW8"/>
    <dbReference type="FunCoup" id="A0A6P7FDW8">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278090.2">
        <property type="protein sequence ID" value="XP_028133891.1"/>
        <property type="gene ID" value="LOC114329076"/>
    </dbReference>
    <dbReference type="GeneID" id="114329076"/>
    <dbReference type="KEGG" id="dvv:114329076"/>
    <dbReference type="CTD" id="38864"/>
    <dbReference type="InParanoid" id="A0A6P7FDW8"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="39"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="263"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028133891.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="45717" checksum="277FAD18D0D66A46" modified="2020-12-02" version="1">MACLQKVSKEFLKKGVRLSPSLAKYSSSAPGGYNFTLNDTQREFQELARKFTREEIIPVAAEHDRTGKYPLDILKKAWALGLTNNHIPEKYGGMEMGVFDGCVIAEEIAYGCTGIKTALEGSGLGQTPVLLTGNDEQKKKYLGRLIEEPLVAAYAVTEPSAGSDVNGIKTRAEKKGDEWILNGQKMWITNGGVANWYFVLARTNPDPKAPASKAFTGFIVEREWAGVTPGRKEINMGQRASDTRGITFEDVRIPKENVLIGEGAGFKIAMGTFDMTRPPVAAGAVGLAQRALDEATKYAMERKAFGVPIAHHQGVAFMLADMAIGVETARLAWMKSAWEVDQGVRNTLAASVAKCYAADIANKCATDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTAQIQRLIISRAIFENAKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFF6</accession>
    <name>A0A6P7FFF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114329755</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028134764.1">
        <property type="nucleotide sequence ID" value="XM_028278963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFF6"/>
    <dbReference type="FunCoup" id="A0A6P7FFF6">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278963.2">
        <property type="protein sequence ID" value="XP_028134764.1"/>
        <property type="gene ID" value="LOC114329755"/>
    </dbReference>
    <dbReference type="GeneID" id="114329755"/>
    <dbReference type="KEGG" id="dvv:114329755"/>
    <dbReference type="InParanoid" id="A0A6P7FFF6"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="89"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028134764.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48369" checksum="1E11485005D3AD9D" modified="2020-12-02" version="1">MVVNRSFLLFGKTVVRRFQHKVDVIGRQYSTEGPLFPGAKTTWTENLEFTGSHSYKPIPVYRVLDRQGNVINPENDPKLPDNILVKMYKDMTLLGALDKVLYEAQRQGRISFYLTNYGEEATQVGSAAALDTSDVVYGQYREVGVLMWRGYSLQQFVDQCYGNIDDPGQGKQMPVHYGSKELNFVTISSPLSTQIPQAAGSAYALRGKNRVVACYFGDGGASEGDAHAAFNFAATLNCPVIFICRNNGYAISTPVEEQYQGDGIAARGPGYGINTLRVDGNDVLAMYNVTKMAKEYALKESKPVLVEAMTYRVGHHTTSDDSTKYRDPKEVELWAKNDYPTDKLKYYLNKKGLWDDKQDKEWLEAARKSVMEAFKVGEQKMKPKWDVMFTEVYKYIPDHLKKQKTEMEQHLSIYKQHYPLDKFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGZ5</accession>
    <name>A0A6P7FGZ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114329330</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134187.1">
        <property type="nucleotide sequence ID" value="XM_028278386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGZ5"/>
    <dbReference type="FunCoup" id="A0A6P7FGZ5">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278386.2">
        <property type="protein sequence ID" value="XP_028134187.1"/>
        <property type="gene ID" value="LOC114329330"/>
    </dbReference>
    <dbReference type="GeneID" id="114329330"/>
    <dbReference type="KEGG" id="dvv:114329330"/>
    <dbReference type="InParanoid" id="A0A6P7FGZ5"/>
    <dbReference type="OrthoDB" id="10054061at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028134187.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11315" checksum="342FB531B547D6AA" modified="2020-12-02" version="1">MSNEGFDPCQIVRGLWEHEMSMRRLLDVLRNSQSYCTDNECLDVGTSSSTANPDYMLLVVLAMFTAVFLYYFRPGSQTVHGDSKPRNNGNNSDGAPPSSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK33</accession>
    <name>A0A6P7FK33_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114330257</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028135382.1">
        <property type="nucleotide sequence ID" value="XM_028279581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK33"/>
    <dbReference type="FunCoup" id="A0A6P7FK33">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279581.2">
        <property type="protein sequence ID" value="XP_028135382.1"/>
        <property type="gene ID" value="LOC114330257"/>
    </dbReference>
    <dbReference type="GeneID" id="114330257"/>
    <dbReference type="KEGG" id="dvv:114330257"/>
    <dbReference type="InParanoid" id="A0A6P7FK33"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028135382.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="59738" checksum="3199D4D138BA6223" modified="2020-12-02" version="1">MIKKLLYICLLSYYGLFTITNGARILGVFVMSTNSHYVLSNTLMRGLAEAGHDVTMVSPYYDKKPVQNGTYRNIVLTGFVEEYTVFSKKRNHYEADFINKVTYLLGLHNAVFPIIEKTLQHDNFQNLIKSGTEQFDVVVVEQFHSDAFKALAWYYNAHLVVLSPGASSCGTNSLVGSPTELAYNPMPYTNFPTDMNFFQRVHNTIIYSFEYLANQLYFLPQHNQLIQQHFPGCPDIFELLTNVSLVLTNSHESFTPSKPLVPNLINVGGLHIQPAGILPENLQRYLDESTDGVIYFSMGSHLKSSGMSFDKMQYFIQAFKRLKQNVLWKWEAEVLPGKPANVRIEKWVPQMEVLAHPNVKVFITHGGLLSFYESIYCGVPVLAIPVFYDQASNAINGVQEGYALSLPYHDPKFSEEAIYSYLQQLLTNSSFAENAKTRSNIFHDRVMSPIQTATHWIDYIIRHKGAQHLRSRRLQLPWYKYFLVDVVLFLLLFVLAIVILVSLFCFLLYRLLRKQNKIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FV44</accession>
    <name>A0A6P7FV44_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114334494</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140339.1">
        <property type="nucleotide sequence ID" value="XM_028284538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505988.1">
        <property type="nucleotide sequence ID" value="XM_050650031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FV44"/>
    <dbReference type="FunCoup" id="A0A6P7FV44">
        <property type="interactions" value="1488"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284538.2">
        <property type="protein sequence ID" value="XP_028140339.1"/>
        <property type="gene ID" value="LOC114334494"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650031.1">
        <property type="protein sequence ID" value="XP_050505988.1"/>
        <property type="gene ID" value="LOC114334494"/>
    </dbReference>
    <dbReference type="GeneID" id="114334494"/>
    <dbReference type="KEGG" id="dvv:114334494"/>
    <dbReference type="CTD" id="32665"/>
    <dbReference type="InParanoid" id="A0A6P7FV44"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028140339.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47689" checksum="03FD79AA6FC476D7" modified="2020-12-02" version="1">MSELRKSITTVCEKKFLLKNLAEYTRLDGRAFDEFRNVSIDFGKDWGCCHVSLGKTRAIAQVSSEITQPRSSRPSEGILNLNIELNPLAAAHFEAGRPSDLGVQLNRLLEKCLKDSKAVDLESLCIKMNEKVWSIRVDINLLNYEGNILDCASIAALAALAHFRRPDVTCDGEEFVIHTVKERDPIPMVIHHYPVCVTYSIFDGGKYILADPNLLEEGVSDAFMSIGINSYKELCGLHLGGKADLAPDVILATASKAGKRAGLIVQQIKQTVEKDSVERLEKHKQGYGFGLQSLNIDYDVPEDINKYIDKWESKMKKTKKKGKEKKEKKSDQSMDTTMEEIDTVVAEIEKCGEGTAALVPIDHKDKNPWHDSDSDNQYGDNEVIFIEQPKPVVDLRDIETDSEEEAVVILNANQKTHKKKQKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYK7</accession>
    <name>A0A6P7FYK7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 664-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114334089</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139907.1">
        <property type="nucleotide sequence ID" value="XM_028284106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517474.1">
        <property type="nucleotide sequence ID" value="XM_050661517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050661517.1">
        <property type="protein sequence ID" value="XP_050517474.1"/>
        <property type="gene ID" value="LOC114334089"/>
    </dbReference>
    <dbReference type="GeneID" id="114334089"/>
    <dbReference type="KEGG" id="dvv:114334089"/>
    <dbReference type="InParanoid" id="A0A6P7FYK7"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000086">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028139907.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="53040" checksum="B209D6398575A470" modified="2020-12-02" version="1">MDETLVKQEIFEDICTQQSIQNEQDDFLPVEIKIQPQCDLNYLYQTNNEIDIKNIKIEENKDEYDEDKKVVENMQIKKELEECNEGHQENPQSTSVDLDVLKLETEQKDNSGFHADKNGIKHKKLHTVEKPYKCEICFKQFTLKGNLNMHMKLHTDDKAHKCETCLKQFSQKAHLKDHMKMHIGEKPYKCNICSKQFTQKSGLKVHMKVHTEEKADQCEFCLKWFSRREQLKNHLRTHTGEPYKCDICLKEFHKRNNLSIHMKIHAEDKPYKCEVCLKGFSHISNMIKHKKVHTGEKPYQCEICSRHFSESGTLRVHLRMHSGEKPYQCDICLKRFSEGATLRIHSRIHTGEKPYQCEICFKRFIQNCKLNRHMDVHVKDKDTSYQIDTQSGKKMHTCEVCLRQFSKKSNLNVHTRVHTGEKPHQCDICLKQFGHSGHLNRHLKVHTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZQ2</accession>
    <name>A0A6P7FZQ2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase family AAA domain-containing protein 1-B-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">ATPase family AAA domain-containing protein 1-B-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC114335935</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142026.1">
        <property type="nucleotide sequence ID" value="XM_028286225.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028142027.1">
        <property type="nucleotide sequence ID" value="XM_028286226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZQ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657197.1">
        <property type="protein sequence ID" value="XP_050513154.1"/>
        <property type="gene ID" value="LOC126888811"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028142027.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42136" checksum="DDBD4BB94B30BBFC" modified="2020-12-02" version="1">MADTAFTKNEVIGLVVRLTLVSAVTFLSIKWIMNQVDPTNKSKKKARRQAEEQLKRLSATGHAPVLIEKLNDYEMMIAAHLVHPQDIKVTWSSIAGLEGLIQELRETVILPIQRKELFADSQLTTAPKGVLLHGPPGCGKTLIAKATAREAGTRFINLDLSILTDKWYGESQKLAAAVFTLAVKIQPCIIFIDEIDSFLRSRTSSDHEATAMMKAQFMSLWDGLITDLNCTVIVMGATNRPQDLDKAILRRMPATFHVPMPNAAQRRQIMRLILENEPVSDDVDMEALASSTDGFSGSDLREMCRNASVYRVRDYLRNHIDTPIPASSQKDDEEEEVFHDTLRPISMEDLKLSFNKMRGSKLQCGSLQIQTRIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G084</accession>
    <name>A0A6P7G084_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC114332901</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114332901</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138487.1">
        <property type="nucleotide sequence ID" value="XM_028282686.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138488.1">
        <property type="nucleotide sequence ID" value="XM_028282687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G084"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282686.2">
        <property type="protein sequence ID" value="XP_028138487.1"/>
        <property type="gene ID" value="LOC114332901"/>
    </dbReference>
    <dbReference type="GeneID" id="114332901"/>
    <dbReference type="KEGG" id="dvv:114332901"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045182">
        <property type="entry name" value="JINGUBANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844">
        <property type="entry name" value="F-BOX AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF387">
        <property type="entry name" value="F3I6.5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028138488.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32162" checksum="7CC16AE3EF0EC210" modified="2020-12-02" version="1">MPLRIDSRADDVDKHEHDINCLLFNEGKLYSGADDGTIKCWLPDLTKKSEIKANSCSVYSLAGDNNCIYSCSNEGSVDSYALDTLEKKSVLLHNSEVEYWRVRSVNGVLYSGDNEGFVKVWKNGTLYGSINICEPVKDMVIFKNLLITANMGIVVTDLKLEGEHIQFGVKDSLGGTFPLTLIGGKYVAHVTKEATDIVVNEVSDSGHIKQIAKTEGAHTKIINSLAGARWNNKNIIFSGGWDKNIKKWIIENNSITLEATIDAGIIVNAIEVGRDGEIYAGGEDGHIVRIQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3H6</accession>
    <name>A0A6P7G3H6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335521 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335521</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141577.1">
        <property type="nucleotide sequence ID" value="XM_028285776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3H6"/>
    <dbReference type="FunCoup" id="A0A6P7G3H6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285776.2">
        <property type="protein sequence ID" value="XP_028141577.1"/>
        <property type="gene ID" value="LOC114335521"/>
    </dbReference>
    <dbReference type="GeneID" id="114335521"/>
    <dbReference type="KEGG" id="dvv:114335521"/>
    <dbReference type="InParanoid" id="A0A6P7G3H6"/>
    <dbReference type="OrthoDB" id="6328618at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031993">
        <property type="entry name" value="DUF4789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177:SF7">
        <property type="entry name" value="GH11627P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21177">
        <property type="entry name" value="IP06524P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16033">
        <property type="entry name" value="DUF4789"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028175496" evidence="1">
        <location>
            <begin position="27"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4789" evidence="2">
        <location>
            <begin position="261"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141577.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="51916" checksum="00FFFB23B8D1A602" modified="2020-12-02" version="1">MRKIFGIQIWFFLLNLLLHLFQYAKGAVMPPPWANPKLNPCASHPLGWQLLFWPPDGKCYKIFQVGHPCPSGMELTPSLSKSGKNLSAECKCVPQTAQSATNGVCYPLFSAGPCNEGFYFGPDTKYKSENSKRQWGTCKQIKSCSKENEIYWPKDGKCYKKFSRGPCAKGQLIIEDSKSKIPICSCDDTQLHEYRHYDNRCYQHYTKGPCQEKGHLFLPGKTCNCFNNLANYHQESQQCFELGTAGPCSSGQKYDLQLPTDSHASCHCKPKYIPYQNSTSCYRLYTKGPCAKGQILLDSNTCIRQPCERGSLYFPDENKCYRIGIRGPCPTNRVVAFDFDTRPSIDGISYNGVCVCAKKDCEPMLELCDRSKGLIRYKGQCHKMYTQGPCSRGSWLVPKRNGRDEVLGEGSKERLGVCECIPGYARKVRTIGNETVSVCMSPTVVLAEYLNGNRTEITVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6T0</accession>
    <name>A0A6P7G6T0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114334392 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114334392 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114334392</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140229.1">
        <property type="nucleotide sequence ID" value="XM_028284428.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140230.1">
        <property type="nucleotide sequence ID" value="XM_028284429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6T0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650728.1">
        <property type="protein sequence ID" value="XP_050506685.1"/>
        <property type="gene ID" value="LOC126884660"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5970161at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044651000" evidence="1">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140230.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53212" checksum="6D9628F3C719C978" modified="2020-12-02" version="1">MLSKNDVLFVLFATFFGASNASVRINFGRCGAGGFTCSTYPKTNTLAVYYNCVGDDVSLYINQFSSPSNIETLLIQNCVNLTISFRCTGENKNILGLVVRNVKRLKIEPQQYTSHVPTSVAFENIAFIEEIPKDTFAQIQKTTHSYGCIIPKKDFYALSFKNVTIDTVGSRAFQMPENFGNFTFTDVKINRVQTSALLAKLEKLAQFIIEDSKIEVMEHLAFQVTSKNVEIKNNKFVDIASSAFNGTAEKFTFYNNYVNTFHPYAISILVTNVYIWKNTFEYLKSGALQKISPGLLEDSGRNFGSLRFIYQFKNNTIHSMDAGSLNPDVEAYKNVATKMMLEGNLIKCECINIGWIFSGSGHGSNTPMLENFYLTLLDPNSNNKCSASCNLPLSVSSEMIRNGQCSEDITVSLLCGSKDKLQVTNNPTTTTSVQSGTSPSKQTLRRPVVVFLNSKSTMFTKNLDLLFFVCFIYYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6Y6</accession>
    <name>A0A6P7G6Y6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Paramyosin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334745</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140633.1">
        <property type="nucleotide sequence ID" value="XM_028284832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6Y6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284832.2">
        <property type="protein sequence ID" value="XP_028140633.1"/>
        <property type="gene ID" value="LOC114334745"/>
    </dbReference>
    <dbReference type="GeneID" id="114334745"/>
    <dbReference type="KEGG" id="dvv:114334745"/>
    <dbReference type="InParanoid" id="A0A6P7G6Y6"/>
    <dbReference type="OrthoDB" id="6708928at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140633.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="86660" checksum="B6208B804C277231" modified="2020-12-02" version="1">MQNQNQFLESMLVRLLDEAKKLSNDKDPPVSPEEERSNKTLKKEIEKLIIENKKIQKLRSKHVRIKEDRTQKKAKCLSILENNVSEIEDLSKQVESLSLKKQKYREEIAKLRNTLTKKDEIIKNLKATKHTSDINSGTRDCPHDNIDLRDQLDRCKKQYCKKEKSYIKQIEDYKQESQKFKQLYENLKSEKGLDQLDQKCFHRSDEPAELHKLTQKLKSLEKELEASTLELAEYEEENKCYCQKIETLLKTIKCLQEAKLRSEQDSAEYCERVSRLRTEFQKICEEKNKDIQELNKKLQVMKNHEKEIIDLMAHKDDEIKLLKERIVQLDSDNKKYLVMESKYKECQKEYETFINHLNASQKLLTETYSKLDSCDKIINDLKSRNSALEEKISELQFSLDEKVNGIATWEIKINELQCANLKLNKELKTKESAIRSLESCLQRSNRILENCEKEMNMVEERNQIFTNEMCELKSRLEADLLQNQYSPVQCKDIDRDNDKNYSDDNSDTEITNLKNKYDDLLTTAAARENDIEYIKSQIVKCFGKEVCQYTPSSGNEQSEIGNMHFNRTGQLGKSLSHGNENQFLKRPESRWGSRMEYQKCKPRSRSPKMTLYFVRAQSCPGKKVTHILRVRSFSAPSFCRNWDASTVTEAAMDILNPFSISGGKSADEYSEAGSLSKHVRGLTHKRQQNDIRSVKSDSSLEDNLIKPCEAASSSTSTRSPCTCMSVISRRYSQDRPSRKHCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G983</accession>
    <name>A0A6P7G983_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-dependent DNA/RNA helicase DHX36-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114337220</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DExH box helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143427.1">
        <property type="nucleotide sequence ID" value="XM_028287626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G983"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287626.2">
        <property type="protein sequence ID" value="XP_028143427.1"/>
        <property type="gene ID" value="LOC114337220"/>
    </dbReference>
    <dbReference type="GeneID" id="114337220"/>
    <dbReference type="KEGG" id="dvv:114337220"/>
    <dbReference type="InParanoid" id="A0A6P7G983"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="8">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="187"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="548"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028143427.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133422" checksum="EC5572B775C51AE5" modified="2020-12-02" version="1">MGKSKGVYDPAKIQRPLSKKAQRNQNLDTNCLENTPIIMRMEIDRIFKTFVDDPESSEYIFPSDLNNFQRKYIHFKAAQMNFISRSYGREPNRNLHIRKKAFKQKDTKNFNISICPNSTRCLDNFAIMANENINDVVLQKPKFRGQKRMIGKLSSSKPGVPPEAKYNPELKRFRNSLPVYEHRNEIVETIKANKFVILSSETGSGKTTQVPQYILEDAFAKRTPCKIICTQPRRISTVAVAERVAVERRESVGDTIGYHIKLEQKYGAHSNLIYCTTGVFLRNLMGSSDALQNITHIIIDEIHERDKLSDFILICLKQHVHNFPNLRVVLMSATINCQKFVDYFTDVKVLSIPGRVFPIETHFLEEILASTNYMSPKMLEADCNGKSKKKKPVNTAYEKVEKVDEDVDEMNECMDEELDSYLTFSDNYDYTVDHEEATAQIFMYFISEGVSVNYQHSQTGRTALMLAAHLGDKTFISRLCNMGADLNLRCKLGQTAFDYACNEEIIMLLKYVQDEREGEPVADPQTEGLRLLDLYDITTPEDVIDFNLIVTVISSIHNSGIPGSILVFLPGYDDIMMCSDSIERSDALRDNNYKIFYLHGSMNIKEQNDVFKEIGRRKIILSTNIAETSITIVDVVYVIDVGKAKEKAFDAYNKVSSLHTKWISQACANQRKGRAGRTKPGRCFRLYSKQRYENMDVERVPEILRISLEEICLHAKVRAPDDMDIDGFLSLALDAPAANSIRVAVEHLQFLGALDKDEDLTVLGSYLAQLTLEPHLGKILIGGVITKCLDPILTLVATLSHKDPFQLPPQANLKTMAAGKRKELINGVLSDHLLYLELFRKFEEATASGNASRFCQEYFLSQNAMSSIIKTKSQLMAQLKMLNFVTSSSAGSYRNTHSDCWPLVKGLICTGLYPNVAYPHGNKLQTRRATCPSISNFSACSHQEIRAWLVYDEMLKQKGGFSLRGVTAVTPLTVGLFCGMDTIIESPTELEIDDWLNFSFPNANVINLRKALDNIYQKVITEPSYRYSKFDDLTLNTLETVLNEEEKTAELRIPRYFDPLQTLSTYVPPHLRRHAPSNHHRHEQNSRGGAVPRGGLYRNDFRPGGSHSRGHHQQSYSRQNHYRGTNSYRRVKTGNSSRSIEAATEDNNICGSMETLNLVPQSPADFLLSAITKNRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GB52</accession>
    <name>A0A6P7GB52_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC114340034 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114340034</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146546.1">
        <property type="nucleotide sequence ID" value="XM_028290745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515208.1">
        <property type="nucleotide sequence ID" value="XM_050659251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GB52"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659251.1">
        <property type="protein sequence ID" value="XP_050515208.1"/>
        <property type="gene ID" value="LOC114340034"/>
    </dbReference>
    <dbReference type="GeneID" id="114340034"/>
    <dbReference type="InParanoid" id="A0A6P7GB52"/>
    <dbReference type="OrthoDB" id="6624782at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14813">
        <property type="entry name" value="bZIP_BmCbz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="437"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028146546.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="56916" checksum="B33E9BB8CD8C8A82" modified="2020-12-02" version="1">MSYYFAMSLSTWSLPAKFTTFVDPIEKYLSHTRHEVGVSLREQIEEDLMTATEKRHSFESSAIDPVSFMYVDPYDVNPLSRSSDLPPATILADIPLKVESSVSQQSQFATGGGVFYVPPRRIKLEMEEFGDLSSFVSPQRIISNAVDELNTPVFDKDAFDFDISSYQTNVQAHLMLKCDAAFFRENSSLNPLNNQEDVFINPENMHRNAVAFNNQQLYTDADIYSPTASENGTYIVKQSPDNSSMFDMDINSSVSVRSSSSRHSSYPSSPVGSVVRPAATETPDDSEMSFQSSSSSKPRLSLDLGLVHQTNFLDVNTPSIIAEVVSLESTGFNILDLVKEDDIQFVNDVFPDASTSTPPSNVSQKVAVKQPRRRHRMADDDDDEDYVPPSMKTSRYPVAHDYSSDSEDEKPLKKKARGRPPKRTQSISSDCSKDSDVSKYRELRDKNNEASRKSRMKRKVKELEMDKEADELHNKNIKLKAQVEELEKMVNNFRDNLFKIMINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCR7</accession>
    <name>A0A6P7GCR7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114336493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114336493</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142668.1">
        <property type="nucleotide sequence ID" value="XM_028286867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCR7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286867.1">
        <property type="protein sequence ID" value="XP_028142668.1"/>
        <property type="gene ID" value="LOC114336493"/>
    </dbReference>
    <dbReference type="GeneID" id="114336493"/>
    <dbReference type="KEGG" id="dvv:114336493"/>
    <dbReference type="InParanoid" id="A0A6P7GCR7"/>
    <dbReference type="OrthoDB" id="8018451at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028142668.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16270" checksum="3296CFBB4E656ABF" modified="2020-12-02" version="1">MTDGASSSVLQDISASGVDRISVKIPPFWPNDPEIWFLQVESQFTLANITSNSTKFNYIVANLETAYISEVRDIIVSPPATEKYVKLKAELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPDNIVVILAGFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFD7</accession>
    <name>A0A6P7GFD7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337471</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028143713.1">
        <property type="nucleotide sequence ID" value="XM_028287912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFD7"/>
    <dbReference type="FunCoup" id="A0A6P7GFD7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287912.2">
        <property type="protein sequence ID" value="XP_028143713.1"/>
        <property type="gene ID" value="LOC114337471"/>
    </dbReference>
    <dbReference type="GeneID" id="114337471"/>
    <dbReference type="KEGG" id="dvv:114337471"/>
    <dbReference type="InParanoid" id="A0A6P7GFD7"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027872787" description="carbonic anhydrase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028143713.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35598" checksum="D4B53C6EF9365ABD" modified="2020-12-02" version="1">MVVKFGCLKIKIFVVAVLLKLSYGQDFGYEGSIGPAFWGLTYKGCNGGKLQSPIDIEINNVVKINFPPLSFENFDKPLETVRLENNGHTVQLSIRQGDIPKIRGGPLNGTYRFQQLHFHWGKDDHEGSENLINNRSYPLETHLVFYKEDYGNFSNALADDDGLTVLSFLYHITILENKKYEKFEQELPQVENMNSSVEIVNFDSLNDFTTTDRDTYFTYKGSLTTPPCSEVVTWIEFAQTIPLSHEQLQVFRLITGNAGKIDHNFRPVQAVNDRVIYASVPTTDSASSKIEHTTWLLVVSLFKTYLLFSFVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFP7</accession>
    <name>A0A6P7GFP7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tudor domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114341890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148499.1">
        <property type="nucleotide sequence ID" value="XM_028292698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFP7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292698.2">
        <property type="protein sequence ID" value="XP_028148499.1"/>
        <property type="gene ID" value="LOC114341890"/>
    </dbReference>
    <dbReference type="GeneID" id="114341890"/>
    <dbReference type="KEGG" id="dvv:114341890"/>
    <dbReference type="InParanoid" id="A0A6P7GFP7"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028148499.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18942" checksum="B85F8335C38D25E6" modified="2020-12-02" version="1">MMEQLQKKYKDVTYSPLTLDQIEPGNIYASRFDDGNWYRTTVIKVIHDGSISVFYCDFGYYSNLTLQQLFPLDVKFLTLPYQALKAKMSGIRPKDTNWTVKHCDKFKEMVERKNLYSLILNIEQDQLYDSDLVLELMLIERSSEDDVNIDEYLISKGIAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GG31</accession>
    <name>A0A6P7GG31_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tipE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114342060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148659.1">
        <property type="nucleotide sequence ID" value="XM_028292858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GG31"/>
    <dbReference type="FunCoup" id="A0A6P7GG31">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641458.1">
        <property type="protein sequence ID" value="XP_050497415.1"/>
        <property type="gene ID" value="LOC126878632"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GG31"/>
    <dbReference type="OrthoDB" id="8190202at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031578">
        <property type="entry name" value="TipE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335:SF6">
        <property type="entry name" value="PROTEIN TIPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335">
        <property type="entry name" value="TIPE PROTEIN TEMPERATURE-INDUCED PARALYTIC E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16972">
        <property type="entry name" value="TipE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028148659.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36418" checksum="296AB51E72F658D4" modified="2020-12-02" version="1">MDQEEIPQTWQQKLLFYTTAFFVLLGIFSLFSFLFLVPFVIDPAFTTIFMEFDEEPAYCVTVRTDRRLGASNCSWTSCREGCTKDIYTCTQIFVNYKATIRSNISVSSTVQPMSQRETRAIVEEYNYDDESTGTEDDLGWSFQEARLFPNVKGCGYPPMLNCSIFLKAYQEIGSNFSCYYSRVDPNLVISHLDMWQVYMNLVYAMAIPIPSFIISVVYLAIAYFKIYNEDEEEVPLKKNAEDIDMEGESGPDGTLIPSASGGLTPASEAFREDLASFGHHLKVAMVDDISRENLADGVINSVSVGGNIGKTMTTSISTTGGPVADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GI83</accession>
    <name>A0A6P7GI83_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114337283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114337283</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028143495.1">
        <property type="nucleotide sequence ID" value="XM_028287694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GI83"/>
    <dbReference type="FunCoup" id="A0A6P7GI83">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287694.2">
        <property type="protein sequence ID" value="XP_028143495.1"/>
        <property type="gene ID" value="LOC114337283"/>
    </dbReference>
    <dbReference type="GeneID" id="114337283"/>
    <dbReference type="KEGG" id="dvv:114337283"/>
    <dbReference type="CTD" id="34646"/>
    <dbReference type="InParanoid" id="A0A6P7GI83"/>
    <dbReference type="OrthoDB" id="6110560at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23592">
        <property type="entry name" value="TFP_LU_ECD_Crok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028143495.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17413" checksum="2C6C61E59D174171" modified="2020-12-02" version="1">MELNLKFIFITTVVIALVLIKSGFSIKCWDCRSDADPKCSDPFDNTTFAITDCATLKELHYLKGVRPTMCRKIRQKVNGVWKYIRSCAYLGEPGIGGDERYCLLRTGTYNIFMEYCTCNTKDGCNTSSHLKFSPLLFLCTMSISTFAWLKLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJK1</accession>
    <name>A0A6P7GJK1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 345-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337645</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143955.1">
        <property type="nucleotide sequence ID" value="XM_028288154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJK1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653461.1">
        <property type="protein sequence ID" value="XP_050509418.1"/>
        <property type="gene ID" value="LOC126886503"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GJK1"/>
    <dbReference type="OrthoDB" id="8300205at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000742">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028143955.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="61340" checksum="6136A87E3F9E32E1" modified="2020-12-02" version="1">MEFNSEIKEKYDQRCIHSQLSTSTDFVDLKNEPQDNSAMEVKVEMKEECAENDQGYVESLLITPQELRDLKNEPEEDRSAMEVKVEIKDEFAEDNQEFIQSQPITPIDVRDLKDEQYKDNLGFPDQKNTVEILKMSPEHSYRKQQISLDTEELTLKQSICSKNFNYKNNSKKHKKVGTRKGIFKCEICVKQFTRSDSLKIHLRVHTGEKPYKCEICFKQFSQGGGFKQHMTLHTGEKPHKCEVCFKKFTKAGHLKRHCMIHTGEKPYKCEICFKQFSQAGALKQHMTLHTGEKPYKCKICCKMFSKAHNLKRHLRTHTGEKPYQCEFCLQQFNEAGNLKRHLIVHTGEYPYKCEICLKQWAQSSDLKNHLRIHTGEKPYKCEICLKQFSQASILKKHLSMHTGEKPHTCEICLRPFSTTHHLKEHMRTHSGEKPYKCETCLKQFSEAGTLKKHVRIHTGEKPYQCEVCSKQFSLAFSLKQHVRIHTGEKPFECQVCLHQFSQRGALKRHMKLHTREKPDCDIYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKH6</accession>
    <name>A0A6P7GKH6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114343506</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150144.1">
        <property type="nucleotide sequence ID" value="XM_028294343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKH6"/>
    <dbReference type="FunCoup" id="A0A6P7GKH6">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656535.1">
        <property type="protein sequence ID" value="XP_050512492.1"/>
        <property type="gene ID" value="LOC126888358"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GKH6"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028150144.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37211" checksum="1CD0457EC4DFE6F4" modified="2020-12-02" version="1">MNELDSLRQEAETLKNAIRDARKAACDTSLVQATSSLEPIGRVQMRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIVTSSGDMSCALWDIETGQQVASFLGHTGDVMSLSLSPDMRTFVSGACDASAKLWDIREGLCKQTFPGHESDINAVTFFPNGFAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDSMKTERAGILAGHDNRVSCLGVTDNGMAVGTGSWDSFLRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GV95</accession>
    <name>A0A6P7GV95_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114341194</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147785.1">
        <property type="nucleotide sequence ID" value="XM_028291984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GV95"/>
    <dbReference type="FunCoup" id="A0A6P7GV95">
        <property type="interactions" value="1219"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650499.1">
        <property type="protein sequence ID" value="XP_050506456.1"/>
        <property type="gene ID" value="LOC126884543"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GV95"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="259"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028147785.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46066" checksum="7E8D1EF00075FFA7" modified="2020-12-02" version="1">MTNNLVKPVSYLVVDTTAFIQNAPLQDVGEKMITCPEVVDEIKNKRQLRRLVVLPYDLIVQDVFPENISIITEFSKKTGDYPSLSATDIKVMALTYQLHKEKSGTEGLRMEPVMQKAEVTTENKALEMNPDVTGFYLPGKTQTSEDNVAGDDQEEYTEEIDQNIEGLDKLDTNDVDNILTPVKDVEESDSEDSNSIEDESDDDSGWITPSNVKTAKQQLNSEIMEENHVEVSCMTTDFAMQNVLRQMNLNVSALDGRLIKQLRTYILRCYACFKTTSVMTHKFCPKCGNNTLKKVAVSLDAQGKMQIHINSKRPLTGRGKKYSLPRIKGGKHPNNPILVADQPMPDNRPTRLARTKTNPLDDDYTAGFSPFVMRDVNSKSAQLCIRPGQEFKYWMKKNPNETRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVB0</accession>
    <name>A0A6P7GVB0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable Golgi SNAP receptor complex member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114343339</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 10">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the GOSR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149957.1">
        <property type="nucleotide sequence ID" value="XM_028294156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVB0"/>
    <dbReference type="FunCoup" id="A0A6P7GVB0">
        <property type="interactions" value="2250"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659672.1">
        <property type="protein sequence ID" value="XP_050515629.1"/>
        <property type="gene ID" value="LOC126890600"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GVB0"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028149957.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24031" checksum="C700C3443B18D754" modified="2020-12-02" version="1">MDTLYNQTNKLIQQTQANFQLLEGSGKNALDIEGDIQQKLDVINSNCNKLDLYTLKVPLDQRQNAKMRCDQLKYDSRHLQAALAAAQQKRLRREAAANEREQLLNRRFTANPDMTSINIDYAVQHQGSLQNAHRGVDEMLVTGNNTLDSLRSQRATLKGAHKRIMDMANTLGLSNHTMKLIEKRVHEDKFIFLLGVFITVIVIILVVIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVI6</accession>
    <name>A0A6P7GVI6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114341275</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028147880.1">
        <property type="nucleotide sequence ID" value="XM_028292079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVI6"/>
    <dbReference type="FunCoup" id="A0A6P7GVI6">
        <property type="interactions" value="1724"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644154.1">
        <property type="protein sequence ID" value="XP_050500111.1"/>
        <property type="gene ID" value="LOC126880349"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GVI6"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028147880.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20344" checksum="12E57A270DF04715" modified="2020-12-02" version="1">MSSAGSSGSGRGRGGQAAVGEQKESKESKPNPKMSKALGTSAKRIQKELAEITLDPPPNCSAGPKGENFYEWVSTILGPPGSVYEGGVFFLDIHFSPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRIARLWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GW09</accession>
    <name>A0A6P7GW09_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase-like protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114342972</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. METTL23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149578.1">
        <property type="nucleotide sequence ID" value="XM_028293777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GW09"/>
    <dbReference type="FunCoup" id="A0A6P7GW09">
        <property type="interactions" value="1718"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293777.2">
        <property type="protein sequence ID" value="XP_028149578.1"/>
        <property type="gene ID" value="LOC114342972"/>
    </dbReference>
    <dbReference type="GeneID" id="114342972"/>
    <dbReference type="KEGG" id="dvv:114342972"/>
    <dbReference type="InParanoid" id="A0A6P7GW09"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF164">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE METTL23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028149578.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26772" checksum="2EFDD1D26A83E051" modified="2020-12-02" version="1">MLFPNIQMTNVQTEQLKKFVFSSKYTVNGEPLEDKLEIIIPELLQASYSFYTWPSAPVLAWFIWENREEFCGKKVVELGAGTALPGIVAAKCGADVILTESATLPKSLSHTRRSCQVNNLVVNQHIKVIGLTWGLFLGNLDLLGPLDYIIGSDCFFEPATFEDILVTVAYLLDININAKFFCTYQERSSDWSIEHLLSKWDLECIVHNINNLGNSIGLNIHDLIGDHSIHLLEISRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1Z8</accession>
    <name>A0A6P7H1Z8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC114349392</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114349392</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155549.1">
        <property type="nucleotide sequence ID" value="XM_028299748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1Z8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028299748.2">
        <property type="protein sequence ID" value="XP_028155549.1"/>
        <property type="gene ID" value="LOC114349392"/>
    </dbReference>
    <dbReference type="GeneID" id="114349392"/>
    <dbReference type="KEGG" id="dvv:114349392"/>
    <dbReference type="InParanoid" id="A0A6P7H1Z8"/>
    <dbReference type="OrthoDB" id="6761115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027888155" evidence="9">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028155549.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15055" checksum="4B53705BB0CCF584" modified="2020-12-02" version="1">MSIMKSTSFCVFLSIFVLFVVAQNLPVGYALECYQCEANAGIGCEKNFTSVLHENCTTGFSCGKTVWKVNDVTRYERRCAASTYCEDQKAIATRENRTLVSCSLCNATLCNSGNHVNIPIVTLVISILVSLKVVCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H3X3</accession>
    <name>A0A6P7H3X3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114344057</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150710.1">
        <property type="nucleotide sequence ID" value="XM_028294909.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7H3X3">
        <property type="interactions" value="872"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646992.1">
        <property type="protein sequence ID" value="XP_050502949.1"/>
        <property type="gene ID" value="LOC126882177"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H3X3"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5 8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="11">
        <location>
            <begin position="105"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="917"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1288"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028150710.1"/>
        </source>
    </evidence>
    <sequence length="1319" mass="152069" checksum="9A337886953C4E4E" modified="2020-12-02" version="1">MSHFTFVIPGNKEDLLRSCINDEYTVRNVSIQKDIPGELKVCRQLLRDEGAEFILSSFDSYYSLLHHGDAVSMDLIFKSYEDLHKGTVELNKALGFLLEDKESLNDEIKIKYTNLLKMLIYLYTQTINLLERRNVAKKQQQQLSMPKGKKKSVKESEEEFEVDKKSVLLVLNNLIQREIYLFWENQVVEESFVNLISGIAYEFLQHPSIKKQTEEFNEIFNVLGYLMKTYNHGTTFVIRVTQLVKLNEHLVQCIPKGIQHLVQNFNYKSLLHELIEELTEWQTDEKNQDNQGARNCATVLSTLAALMPDLMMPEVVSLNNYLYHEPASLRISVIMVIVEVILSNLTSNELSDEQKEFRDELLEMILEHTEDNSVLVRSRVFQQWARMQREMAIPLKYQLKVLEKAVEHLCDKGSMARKFAINCVSTFLSCNAFSANLSLSSMKEELNKHKNLLKEGKEKFNDPKMERLMELQSQWNGIMDQLKKEVEAEVDKGKENDDENEEQDKISLDKVEEVIRLYLYDSKFKEAIQILKWALKDHKFLEKFKKRNAIGDVEFYMVAFYTIFFDVSKVVNQLENREFVNITADDYKQIEILSSKVDFLHQCVEFLQAIDVAIDVCIELLETTSVSDMHEAIEFFVAAYQFNIDRASDGVLAMLRIMQRTEQERKDAIIAAFKTVYLVSDSKTLTEHCTIVVQRLMRLIKTLPATNLPDLQDIISDWVTKGTLDNSVIETLWQIVTQRVNTTVEDEVAAVVLLKMAAIGRKTVISKNINLMTGIAFGERGKSNLQFLAACCKFLAVAYEGVDMNSANFAFKIKPDEQCFLDLVTILGELFFKAVEFYHEALYAGLDFVYKLSSKPETFAEQLLNAVAPKLNKKLSDNPEFEVPQYALIRLCQMCGYIALKQLEYMDDTVYKELKRRQNVRDERKKTSNTGKTSKRKKDKNRSLTATTAAEASHTMNDETVLEGAQAEDTDADFILKILEKDIVIGSGFLSQMALNILQVCERPDIYRSEELQFAGVVALSRYMLVSSEFCRKHIRLIFTIFEKTEYPSIKGTILVHLSDLLTRFPNIVEPWTDRLFHSLNDPLAEVRRSSFFILSKLILSDMIRAHSHIPKMAACLANQDEDLRAMCKTFFLKLSHKENNLYNALPDIFSHFVELNIDEDEMKSTLKVLFDMLENPKHMENIVARFCTKFQCTEDNHEHINISYCLTLIKYNDKALRRLIEEFPCYKHLVHDEEIYGNFRTIIQNCSKQQVGKVDLKGMATELETAIKSVFELQEDGAMPPPPVPKSTKKRPLQGSAKKTRGRKKRKPVSSDSSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H5N9</accession>
    <name>A0A6P7H5N9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Charged multivesicular body protein 1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114346158</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028153038.1">
        <property type="nucleotide sequence ID" value="XM_028297237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H5N9"/>
    <dbReference type="FunCoup" id="A0A6P7H5N9">
        <property type="interactions" value="1011"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297237.2">
        <property type="protein sequence ID" value="XP_028153038.1"/>
        <property type="gene ID" value="LOC114346158"/>
    </dbReference>
    <dbReference type="GeneID" id="114346158"/>
    <dbReference type="KEGG" id="dvv:114346158"/>
    <dbReference type="CTD" id="40036"/>
    <dbReference type="InParanoid" id="A0A6P7H5N9"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028153038.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23077" checksum="FD199780FD70DA61" modified="2020-12-02" version="1">MGNEMSSTAMEKHLFNLKFAVKELERNSKRCEKEEKQEKAKTKQAIQKGNMEVARIHAENAIRQKNQSVNYLRMSARVDAVASKIQSAVTTRKVTNSMAGVVKAMDVAMKSMNLEKISQVMDKFEQQFEDLGVQTDVLENTMGQTTTTLIPQNDVDSLMQQVADEAGLELNMELPEGPQSSAVSTSTVVHEQDELTQRLARLRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H7M5</accession>
    <name>A0A6P7H7M5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114348149</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114348149</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154577.1">
        <property type="nucleotide sequence ID" value="XM_028298776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H7M5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028298776.1">
        <property type="protein sequence ID" value="XP_028154577.1"/>
        <property type="gene ID" value="LOC114348149"/>
    </dbReference>
    <dbReference type="GeneID" id="114348149"/>
    <dbReference type="KEGG" id="dvv:114348149"/>
    <dbReference type="InParanoid" id="A0A6P7H7M5"/>
    <dbReference type="OrthoDB" id="6689110at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027774716" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028154577.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14806" checksum="71889B28F71F15D1" modified="2020-12-02" version="1">MWNINIRILFLFVGFVTIALASRQDILNSIRKHIHECQKEINVSDDFVAEIGSKTESDPKKAGEFAWCVNIKTGIQTLTGEFADDKIKETFKNLEIDESTVKIILSKCKLKTSSGGGEAALFYFQCLNDVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H913</accession>
    <name>A0A6P7H913_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114345809</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152405.1">
        <property type="nucleotide sequence ID" value="XM_028296604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H913"/>
    <dbReference type="EnsemblMetazoa" id="XM_050662896.1">
        <property type="protein sequence ID" value="XP_050518853.1"/>
        <property type="gene ID" value="LOC126892953"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H913"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028152405.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16937" checksum="CA928479CCABE8CD" modified="2020-12-02" version="1">MHNLQHKSTPCNIRLPMQKQVQQQQQNQQYAYQRPQQHIRTYQQKTNSQLHPIYPANFPSTISYPHQQPKFQQQHQQPLINPYYTSSQYPYYPNQTSACKYEYFTEQNYPKSIGTMSGSTIVAPQPQQPPPQQQHQPMTHHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ID07</accession>
    <name>A0ABM5ID07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 60</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130151.2">
        <property type="nucleotide sequence ID" value="XM_028274350.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274350.2">
        <property type="protein sequence ID" value="XP_028130151.2"/>
        <property type="gene ID" value="LOC114326116"/>
    </dbReference>
    <dbReference type="GeneID" id="114326116"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042505">
        <property type="entry name" value="DYNC2I1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022:SF0">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16022">
        <property type="entry name" value="WD REPEAT DOMAIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130151.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="930" mass="105301" checksum="567052CAEB511186" modified="2025-10-08" version="1">MSTRKNVAKPSTTTKKMPSTTSTTPSKVRESSKDRKKKMELQSSEKSKLKTSVRPKISEKAVKPSESKSKPDAKSTMPKKRKPEVPETPSSSRVSTSQFFPSKNMYSNALKSKESAKKVTEPIVKKVTEPTVKKVSKTVESSKSSKTIEKSSKDKPSGRLVKPTHSNIVKSRVSDNKSSEYPSLEENKSIYTSPDSSTMSERPKTATLRKGSIVNTNIVGPDVPRVQIDAVKEKMRKIKSPSPKSETSEEDKYEDDFESYESDFEAYSSSSSTNLDNISVEDTSSSSSTTSLEEFKTRKTGSGQKRAQSTSSDEERKHDSGHFEMNDFKHRQILDNIKESIEKENTNLVLANNPASLSDEGFEEQKSLQFINFLHAKKKYERRKSVETRRKRGKEILSMIRLDSCNFTLFELAPVPYETFIKNYGRGNTIQVSCQTGDDDVDEEVQTEDIGYWTKWTQEPSAFTNFNQSIPNFWETYKSEFLGVGSDDMVSHKTDKTIINENSLNKFILSAGELMLRIQEESVTNVNSSLQKDKNSSPFSDGYYKFNTSEDIFVGSEVSFVYFSCDISNRLVTVHTKKRTSMVAIRNVFNCNEAEVILKPYGIVSCCFFGVRHSELVFMGIEDGTISVWDVRRRIFNKSSVEITVPLFCTDINSGHLTKIVALHHLDVSSEENTYKNQANELCSLDEDGEIILWTVIKKQLEENKAENNLEVVLVKNTNISLKILHPDLPDLQCTDFITSHQNTNYLFISTNYGFIIHHLVKGGRSSVRKFLPGSKSVAKCLGSCPFSSEYFLAGYENGNVNIYSRSSEKPLMTLSDKDNSIQYCPIDLIQWSKNKPVVFYTKDAKNRINIWDLNESDMFPIFSIPFEEEISCMKLSHVCEDVENGKSYLAIGTKAGSLYFHQLNEEHGQQNSQVYEKSVKTFLNYVNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDX5</accession>
    <name>A0ABM5IDX5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130691.2">
        <property type="nucleotide sequence ID" value="XM_028274890.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274890.2">
        <property type="protein sequence ID" value="XP_028130691.2"/>
        <property type="gene ID" value="LOC114326496"/>
    </dbReference>
    <dbReference type="GeneID" id="114326496"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="94"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130691.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="311" mass="36292" checksum="5C617821F038C491" modified="2025-10-08" version="1">MIRRQARLRREYLYRKTIEDRQKSIQDKKDRIQKSLDQHTTIHGDLQKKALHYAKKIEWEDSGPQAAALLGGESGGAVANSQDDEYRYAGVEDPKIVITTSRDPSSRLKMFAKELRLIFPNAQRMNRGNYEMKQLIQACRANDVTDFIVVHEHRGVPDSLVICHLPYGPTAYFNMSDVVMRHDIPDLGTVSEQYPHLIFHNFKTKLAERTGNVLKYLFPVPKEDSKRVITFANHDDYISFRHHTYKTVDRQLELSEIGPRFQLRLYEIKLGTLDTIDSADTEWALRPYMNTTVKRRFFSDEDGWKQDDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IG88</accession>
    <name>A0ABM5IG88_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132072.2">
        <property type="nucleotide sequence ID" value="XM_028276271.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497982.1">
        <property type="nucleotide sequence ID" value="XM_050642025.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276271.2">
        <property type="protein sequence ID" value="XP_028132072.2"/>
        <property type="gene ID" value="LOC114327602"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642025.1">
        <property type="protein sequence ID" value="XP_050497982.1"/>
        <property type="gene ID" value="LOC114327602"/>
    </dbReference>
    <dbReference type="GeneID" id="114327602"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="402" mass="45206" checksum="A8ABB881E7F9CF97" modified="2025-10-08" version="1">MIRSNVCPRMTSTNEHLLPPPPPPKPRTSPMEFRNPDLVSRLLAATPPYLSNMELLPNTFFFSELLKSIVQAKIQRTATFQPPVRRPRKRSWATSRSECLGKAPIESKSEDILLPPPLPPPPPPQASAPPTQEALVDWMLKGNKKQEDNPLELTINKNENPNIFPNHTKVEQSIPQMFPNIHHNIPQDNNSQNLVLPPPPPIWYPPLYPTSPFAIDPLHFFIDLRVSGHIYDKKNQKDNSEASSSSASSSPREKPHTEVSTPKVEPEISNNAFKQSRNCSAFSVPIPSSSRSNYSDKETKPTKFDVKSMGFDKSSNKTSINYVMSNISNIYKNIQQSQDVAIDFIDEGDEEKRVRDLRAALGLDLVVDYMKHKNPRSSNDESSISTDYESVGSPHLDVVDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPW9</accession>
    <name>A0ABM5IPW9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138429.2">
        <property type="nucleotide sequence ID" value="XM_028282628.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282628.2">
        <property type="protein sequence ID" value="XP_028138429.2"/>
        <property type="gene ID" value="LOC114332846"/>
    </dbReference>
    <dbReference type="GeneID" id="114332846"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138429.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="197" mass="23330" checksum="F3056658E33627C6" modified="2025-10-08" version="1">MSVRPDDHRRKWDKDEYEKLAEERIKEEKYQKEEAENKKKGIPVKRELLKIRDYKVDLDSKLGKSIVINKNTPTSQSGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMKVERSSLDSVRKRFEANKKKMEEKKKEYDMASRLQELAEEEEKLKEYRKEKRREKRKIEEDAEEEPQSELASIMGFSGFGSSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR31</accession>
    <name>A0ABM5IR31_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139269.2">
        <property type="nucleotide sequence ID" value="XM_028283468.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283468.2">
        <property type="protein sequence ID" value="XP_028139269.2"/>
        <property type="gene ID" value="LOC114333573"/>
    </dbReference>
    <dbReference type="GeneID" id="114333573"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047477230" description="Superoxide dismutase copper/zinc binding domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="2">
        <location>
            <begin position="680"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139269.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1134" mass="128980" checksum="77D36DF2402B7321" modified="2025-10-08" version="1">MIKWLSSLLLLIVLETSNSLELRSYISSQGLHGTISFTKLKDELVIRTDLKTTLEYPTQIWSWYLTEFPVDYSQLEDRCQNLGKKILPLQDSFGYLILPDNQTAEYVTKELKISGPLGLYGKSLLFRNEDTNQIICASITMVDKTKEKTAVARFNSPIAGNVYFRWFSTSDNQTDMLVTTDLYHVRNKENFSRTLQNTEHSWKIYVTDILESDENRHVDNCNILQLVFDPNDKGRGKAIGDVDQRLGKVKVSTDYNKYKFKTLYRDEELILLPGDLNGPQRRLYLVLFETKHEDAFLGCAKIQYDSAVNTRVIIQSGGIKGDIRMTQHTKFEPTFLTFNLSTARGDVETRLVYSSTVVAYKIHELPMKPSRSVGQNENTCFTTNFVYNPMKINLNNVPPNGFGTQDQYAVGDLSGKLLGRNNETMLVPGTQELSGKYWDTYLPLQGRYSSVHRSLVIYKNTQYPSSELIAEPWICGGITLYEPNFQYEKQIFTAQVLFRYPTVGRMLMRQVKDEPWADTTILIEYLVHADGAALNNSAEHRWAIHELPPGKDFYNWTARCLSSGAVYNPYKVDFDNRTSPDRCNMNAIGICRLGDLSTRQGTIDISGKIADSDKISRKLWTDPMIPLTGFHSVLGKSLVLYDDHGPKARGERLACSRIGGVYRRKAVARDWFPNGYDLTVKGKIEFVQQTEYDITDVDVDLEGLTSVKDYHIHMTPVEENLEFPCEKTSLYSTWNPLNVDAASSPRAYHGTPDQYEAGDLSGKFGSPINHTMYKTYYNDTLLSLFGPRSILGRSIVLFKRNSRRWACSTIERGYSPSEARELRAIASFHNPNGHAFGYMKMRQLIHKDGSPSDTTIEVKLRHPGKNDRNVTREHNWAIYVNPVGVDATVKTLATRCVAGGYVWNPYFTQLADPLNTDLYQQECGPENPLRCHVGDLSARLGTIDIGLERKVFTDSNFPLEGDVTAIGRSIVILAPDRRGERYACANIEPDYDIIKYANIEKPPRFVVAQFIEDIREVMGIPEWFLTVDSRKTRSLHNDGCVQLLLHFKGPIAERLEQDFNKLLLHGRLDAPSLYIPGYINEKRKVKIAYKLCGTKDPNEKSRRKNSFFSRSKASVASLTELTIVVCLILTYMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISY7</accession>
    <name>A0ABM5ISY7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoprotein 3-alpha-L-fucosyltransferase A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140982.2">
        <property type="nucleotide sequence ID" value="XM_028285181.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285181.2">
        <property type="protein sequence ID" value="XP_028140982.2"/>
        <property type="gene ID" value="LOC114335027"/>
    </dbReference>
    <dbReference type="GeneID" id="114335027"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140982.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="22027" checksum="C03AF2EC2C5C308F" modified="2025-10-08" version="1">MARIQWKKYRSLTVAVSLVVLYFIVKTQTYEHTAFVFLPKVHPNKPWEFVADFSNMKYLNPTIIDFNILEESGNYDHWKYTTEYMENLSHWPYLPNKAVAHFNIKASPKKDLYYINSLHSTCLFQGLYCLNAESEFKFSHNNRTKGTTCEETVKYECPRILSFFCRREVIYQRNAIMSNLLKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUB8</accession>
    <name>A0ABM5IUB8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142253.2">
        <property type="nucleotide sequence ID" value="XM_028286452.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286452.2">
        <property type="protein sequence ID" value="XP_028142253.2"/>
        <property type="gene ID" value="LOC114336127"/>
    </dbReference>
    <dbReference type="GeneID" id="114336127"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047124010" description="EB domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142253.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16140" checksum="27B298011D5B2272" modified="2025-10-08" version="1">MKISKAVPFFVFLFTTAVYGEQKCNYSDLTEDDGCGPNEWCVKTNKCECIPQYKRKDNTCILETSDDPKSSNYSNLVDNQGSGAIVAGILIPLFLIVFVMCGVYLTRKYHLVSWLRSRLHRRNETYDEFMIGQDDDDEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYS2</accession>
    <name>A0ABM5IYS2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150079.2">
        <property type="nucleotide sequence ID" value="XM_028294278.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294278.2">
        <property type="protein sequence ID" value="XP_028150079.2"/>
        <property type="gene ID" value="LOC114343448"/>
    </dbReference>
    <dbReference type="GeneID" id="114343448"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047319810" evidence="2">
        <location>
            <begin position="19"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150079.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="907" mass="103018" checksum="B822E725A372CC03" modified="2025-10-08" version="1">MHPHCMLLVLTITALGLAIEQRKPKLVRNTDTNHLRIADPDPNDSEYMKFEATGSNKNNKKVTNKTGDEDKPKTLSQQIADGKYALIQKEIFSKPPKRPGILSYDHNPEVPNDNINNLGGLDKDEIWLAENHLLVLRGGNFPPYDEKRDHPESPWAPLDNYKAPLHQVKIPKNPKIPPPFPVQLTENGPLQILGTNSSRTFNGTYEEALNSISPPEGYPPPAPFFQPYNPDSANFTPWSAPMPIPGNAPPGELPGGLPLPPVNLNGTLPPSLSYLPPGAVILPPPGNQTDYIDYDDPSIYYPPPYSFYYPKDNSSAVPAGPLVPGIILPPPPNFFAQLEDTTGVSPTRKPQRYRKPTTTQVTITITKSTTLTPTTTKKTNVPPKTVKIYPVKNQQYIKEIRTSTTPRPTIKSVTIVPEVFTVPQRPKYQPTQRRKPGVTILRPIKPAETPPKVYSYENEISNQPLIKEYGPPARVTTTAVPLKYQSTSNNIDTNSVTEETGKRNNFRKGKAPKTTLRPAQYYFYEEQEREPEVPVKTNTYVENNEPYYVRPRPIAPQRQRKPQYVYVTAKPYNTQKPRFRFIQQPVSQDTFNIHINKLKDQIQQYYTTPRTTFRNAPKPVYQFSFQAANYPSQQTNFKPSPQVDEQDQFQPIPPKYTVEIQQAIQIIPSEAPKYQENQRPVFYQQTTERPYYTTAAPPEYPQEVVTPRPNYVQNVATPRPISEYSFEATPNPVYQGYYTKPDENYFDDRTKTYFTVFGRKLPAATTPIPQIEPSPLQQGNYQQGSYQQRPISLEGDTLVNYVHPRPNINPDAEIIPVNNPPNYPNVVRYSPRPIPKQNSEIIKAIPYEVPSSESQDGSFISYQLPGDDGAHFYFLTPQLAQRKDQGSGFYYSKARRRRNEKTADVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIS3</accession>
    <name>A0ABM5JIS3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497839.1">
        <property type="nucleotide sequence ID" value="XM_050641882.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641882.1">
        <property type="protein sequence ID" value="XP_050497839.1"/>
        <property type="gene ID" value="LOC126879006"/>
    </dbReference>
    <dbReference type="GeneID" id="126879006"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="128" mass="13939" checksum="9CEED36784E5BE7D" modified="2025-10-08" version="1">MMNVALVCLTAIMGNPERHRVQELVKECQKESGSTVNEIENIRKGVITTETGKQALCVNIKVGALDQNGDVVPDGFKKHVEALTDSIDGRKEFQDKCGKTEGKSSEDKAINFVKCMQSVLAKVSSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMH1</accession>
    <name>A0ABM5JMH1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein takeout-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499139.1">
        <property type="nucleotide sequence ID" value="XM_050643182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643182.1">
        <property type="protein sequence ID" value="XP_050499139.1"/>
        <property type="gene ID" value="LOC126879866"/>
    </dbReference>
    <dbReference type="GeneID" id="126879866"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF14">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046253994" description="Protein takeout-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27922" checksum="8D715EE693B8D93C" modified="2025-10-08" version="1">MRRCIILLFVALFVECKKQLPPFVEPCNRNDPKMDECLARNIKNLQPRLAKGVPELYIPQFAPLIIEKAELEPNKHIKISMRNINLYHIENFTLIDIKYDAKKMHLDLSLEWDLIGVEADATMKGILLNLNLDASGHAEGNLTNIKASGSLDLDRVYRKGVEYLTIKKTDLKIIIGKYVAVLDGLFGGDNELSQKTNQILNEHYKLIIEEFTPVIEQIVKAVVYERHENLFKRIPLDVLFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRH1</accession>
    <name>A0ABM5JRH1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein NST1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500535.1">
        <property type="nucleotide sequence ID" value="XM_050644578.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644578.1">
        <property type="protein sequence ID" value="XP_050500535.1"/>
        <property type="gene ID" value="LOC126880601"/>
    </dbReference>
    <dbReference type="GeneID" id="126880601"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="36396" checksum="0B2808B7D1B37C88" modified="2025-10-08" version="1">MRKFNPMEVKQEPSDFSEEYMIQQESIEFSHIEFPDTVKHEISEDLLNADLANTDTNNYFADSNTLEKVRTDVGVDDIKLEEEEDKAEKVTVQNGIVQKDEIQEEFNKYEQIHIENQLFLEDFSKEPRGAYYSDNLKKRKGPPKKYENEEERKAARLLAAKEGARRRRANQSDEDRAKMAAYKRERRAIIKQNEAQDQAMRQRELEYRRKQRAQATTEQILARRIRDAEARRLRRANETEEQAEARRARESEARRIRRANESEEKKEARRRRDNDARRLSRKLITNSEARPFVSILKTLLVYKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSJ6</accession>
    <name>A0ABM5JSJ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500911.1">
        <property type="nucleotide sequence ID" value="XM_050644954.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644954.1">
        <property type="protein sequence ID" value="XP_050500911.1"/>
        <property type="gene ID" value="LOC126880883"/>
    </dbReference>
    <dbReference type="GeneID" id="126880883"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="88615" checksum="A09A16B432A74586" modified="2025-10-08" version="1">MAEIEAKKKHRKVLRTSFTKAGNRLYSLFKRSEPDFDAIETDWTCFELKYTELQVADNEIYSEMLVEATEENLLAEMEDCDGYKMRFTELHMLFKRLVNARNEVKVVDDSGNSVSSEEELKGKRRFKLPSIQFKRYDGNIKGWLPFWSQFKKIHDDSFIDKCDKIEYLIQATVEGSRARQLVTSFPMVADNYQNIIECMQARFGREDLQIEIYVRELLKLVLENSMATQKLELSLLYDSIETQLRALDTLGITSDKYAAILYPLIESCLPQDILRIWQRSSFCNTASSADRNLGSNLSLNSNMNKDTTLELKLVNLMSFLRSEVENEQKISLASDGFGLAQNFSNLNLKSDSEHVRKRNVKREPLFYTAAGLLNSTDVVKCLFCDRAHESTSCFKAQKMNLEEKKNCLSKHKACFFCLKGGHQARKCRTRLRCILCSKSHVPLMCPNLSTRKFPDLTDKQNVDNTPKDQTLSNFTHTHVFMQTVRVNLKGPNGTCVVRALIDSGSQRSYLLKSVASALGLEAKRRKKIVHCLFGGTESNSTHFCYDVLASHGDYTYNMEVLDQSYICNEIPSAIYGPWTQELKSLNIELSDTEGSGPIELLLGLNVADIFYTGRRHILPSGLVAVETYFGWTIMGKSANTSPVSQANMTCLSLFVNPSITELWELDVLGIQEPSEKKSKEQLALAAKELFLQTVIINQEGRYEVGLPWLERHPSLPANFNVAKRRLHSVVSKLKRDNLFSRYNEVFQEWENLKIIEKTNSDSTTGHFLPHRPVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT73</accession>
    <name>A0ABM5JT73_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501137.1">
        <property type="nucleotide sequence ID" value="XM_050645180.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645180.1">
        <property type="protein sequence ID" value="XP_050501137.1"/>
        <property type="gene ID" value="LOC126881121"/>
    </dbReference>
    <dbReference type="GeneID" id="126881121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="18"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="460" mass="51055" checksum="3672961B08AC54DF" modified="2025-10-08" version="1">MNVLGKRWFLYFCGFSVNVVMVCLGSMMVWTSPVILKLQSNKTLVNPIGRPITVWEFSLFIATYPLGLVIGSVLIAKVPDIIGRKRTLICIASGTLISFIGLFLARNIYAFFIFKFTVSLSLGGGPILIPMYTAEIAEDYNRGRLGFFISVAMTVGQLYGTVIGAFTSVNVFSLLCGLPALLCLICCTWLPESPEYLLTKGRKKEAVIALSRLGKTKKKLDIENELVETQNMLQTNTLTKNNFLKRLRADNAVKRGFYLAVSIMIFQDSIGISIVLGLLGPLLSESSVGLSGDILAIILIIIKFVAVIVATSIVERVGRRILILVALFIAGLSMLFLGLYFYFQQNSYYIPDVFKNLPLFCITCFLVVFAFGLSSVPYILVAELLPSELRSVGSSICQFLGEICMISTSFLYPIAAKYFGVHYCMFFFSFVGFSGFTHLYFLLPETKGKSFLEIRKILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTE5</accession>
    <name>A0ABM5JTE5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501206.1">
        <property type="nucleotide sequence ID" value="XM_050645249.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645249.1">
        <property type="protein sequence ID" value="XP_050501206.1"/>
        <property type="gene ID" value="LOC126881168"/>
    </dbReference>
    <dbReference type="GeneID" id="126881168"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="455" mass="50594" checksum="5992B053E7A2F8B0" modified="2025-10-08" version="1">MSSDVTIQDVPANKSYSTAASQQNFFPGKENAILFSAINNTPLQDYLISLGNLINPKNILFSSRLSNNRICMYLSCMQAVEDFMTNYGSIQVNGETVRARRLITPAERIVLSNVCPSIPHEVIIQELKHLGLNLVSPITFLKISASLPEYSHIKSFRRQVFISPHNTTIPDSILLNYDNTNYRIFISQDSMTCYICKQINHIASNCPSNKNSSSQPSGPLTPPTVQSSDSPTNAGNQVDQTSNNDQNKNTEIFPQVSIPNTSNSTSVEIIQPVSEATQDLKTNENTPLESSATAENIEIISQTSLAITKESPCPSTKRTIEETLSPPVENVVDNQTFLLPAQPHKTKTQKNKKPKRSLPIPESLESYLSKQSTPSILSYDQLMMLIENIQGSQSPIEIVKEFTSDFLGLVNLLTVSYQYIPDRATKYRFTRLKTLLLRFLGEEATTESELSSTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUY2</accession>
    <name>A0ABM5JUY2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501748.1">
        <property type="nucleotide sequence ID" value="XM_050645791.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645791.1">
        <property type="protein sequence ID" value="XP_050501748.1"/>
        <property type="gene ID" value="LOC126881499"/>
    </dbReference>
    <dbReference type="GeneID" id="126881499"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="626" mass="69731" checksum="46F0A0B8616F1DAE" modified="2025-10-08" version="1">MLQIVRKMNPNTICAVNTCPGNLKNSSAALFFALINTITAAKCSFASPSDYPEDYGPFLKDEDEFDFIIVGSGSGGSIVANQLSQNQNWRVLVLEAGGIPSANSDIPGLLFSLQRSEEDWRYKTQQTQGPKGSCLGGNDKQCNWPRGKTLGGSSSINAMIYIKANKKDYDEWADMGNPGWDWENVKGYFTQLENVQPPDDKITHLGTKGLLPITKTRHNSPLRKSMNKGFLELGVPILSEQNPENPIGTVDAPICVHNGIRSNTGREILGAVKNRKNLFTSLHSMVHKLIIDPKTKMTKGVEVKVGNTTLRLRAKKEVILSAGTVGSAQLLMLSGVGPKQHLTDLGIETIKDLPVGKNLQDHLMFVAYELKLDLNAIVPFDPIDAIYEYFKHKTGPLSNIGLTNYLSFVNIRNDSIWPSISYHNLILNPNDESFFYMLFRAHNIPDEVIKEKIKICKDRPCLAHMPVLLSPRSRGEIILNSTSVYDHPLINTGYLTDEDDEDLQVFLEAIRFSDELFFKTKALKVHNPELIRPIAPACDAYKYQSDDYWKCVLRHYAITIYHPSSTCTMGPDENTAVVDSRLRVHGITNLRVVDASIMPRLVSGNTHAPTMMIGLKGADIIKEDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVF8</accession>
    <name>A0ABM5JVF8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein cortex-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501922.1">
        <property type="nucleotide sequence ID" value="XM_050645965.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645965.1">
        <property type="protein sequence ID" value="XP_050501922.1"/>
        <property type="gene ID" value="LOC126881604"/>
    </dbReference>
    <dbReference type="GeneID" id="126881604"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF52">
        <property type="entry name" value="PROTEIN CORTEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51910" checksum="A078527376C10922" modified="2025-10-08" version="1">MKKRQTGRPIALDRFIRKRSISDFETHESTIDDDPFDNAESHDESFHYVNIARERFFHNNYRSMLKNIMLSNKSIIGDNFGNNNVQLKLHEIIEHWPVEARKKPLLLNSPEVFLDLPDLNAHYLNNIVDWGNTGYIATIFDSKVHLWHPNKKDSLEVTTELTVARCIRWNRDGSLFAVAVNNNQVEVFDILGNKFTSNIGSCVCSVQHKDRCRSQCNIISAEWTKSNILLTGCSYGTLTMFSANLKWLNFRFIPNSAAIVKLALSCHENYLASVGIDHTVFIMNYHNFDGIQTFPLPTPKAIAWHPWKDSLLVLGQMDYLFLWNVQSQNISCSMPFPNTYIDSLIFNPMSAELLVSQHCYDEDGNEGVSYLRVMKNLNCIVDEVRCNKCKIPYLMWDPTGTKLGAATTEENFCIWDFFGRGTKQEKKYKGIMQNVDAKDIFKTTNFRGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWT9</accession>
    <name>A0ABM5JWT9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502403.1">
        <property type="nucleotide sequence ID" value="XM_050646446.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646446.1">
        <property type="protein sequence ID" value="XP_050502403.1"/>
        <property type="gene ID" value="LOC114335260"/>
    </dbReference>
    <dbReference type="GeneID" id="114335260"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="295" mass="34662" checksum="C8A2E20CA7B71D2A" modified="2025-10-08" version="1">MSDPDRCQRPSYRRSYKNSTPRHTRYDWREVSYISSGPIHHKLTIDWEKELPQETSKAPKYVVTFDVSGLDHLVEKPLEEYITGSSYIGTHNQMNFSGIGTYYYPHGVIYKGTFKDGQFHGNGTLIYPNGQRVEGVWRNGKLKDSTYIYHDGLQYEKDWNYLRMPDRAYMEEINCGFRPPGTELVSNKKIVTKIPPDTFETGDEGYYDDKKKIIYSKDHKMRRIVDAHEMELIRNNYRQEADKPVKYYPQVYEYWSTGRQRDVKKIQKRYSVGIQSRNSSVDTEATTTEYSIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYN7</accession>
    <name>A0ABM5JYN7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503045.1">
        <property type="nucleotide sequence ID" value="XM_050647088.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647088.1">
        <property type="protein sequence ID" value="XP_050503045.1"/>
        <property type="gene ID" value="LOC126882259"/>
    </dbReference>
    <dbReference type="GeneID" id="126882259"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="566" mass="66124" checksum="312FC9055376ECEC" modified="2025-10-08" version="1">MFKQTEIKQEVSEIIICKREIGNEVDDVLQDNFKTEIKEEPIHDSTNDTCDYLDVKKYPIKAEIEQDDGFSCMDTDARSLLTNHDRSDSNLNQYITSATNVKTGGQRFICIICKKALSNKYCLDIHMRIHTREKNFACEICTKPFSTKAILKQHMRVHTGERPFECEICTRKFTTKQHLQLHLRVHTGEKPFECEICTKQFSAKHSLQSHMTVHTSEKPFECEICTKQFSTNGILKSHIRVHTGEKQFECEICTKQFRTKQHLQSHMTVHTGEKPFECEICTKQFSTKYHLQSHMTVHTSEKPFECEICTKQFSTNILLKSHMRVHTGKTQFECEICNKQFTTKQHLQSHMTVHTGEKPFECEICTKQFSTKHNLQSHMTVHSSEKPFKCEICTKQFAANRLLKSHMREYTGEKPFECEICTKQFLTKYNLQSHMTVHTGEKPFECEICTRQFSTKHNLQSHMTVHTSEKPFECEICTKQFSTKPLLKSHMRVHTGEKQFECEICNKQVTTKQHLQSHMTVHAGEKPFECEICTKQFSTNRLLKSHMRVHTGENHLDVKFAPNNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0R5</accession>
    <name>A0ABM5K0R5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503780.1">
        <property type="nucleotide sequence ID" value="XM_050647823.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647823.1">
        <property type="protein sequence ID" value="XP_050503780.1"/>
        <property type="gene ID" value="LOC126882787"/>
    </dbReference>
    <dbReference type="GeneID" id="126882787"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="381" mass="44077" checksum="C25D513FB3D05E46" modified="2025-10-08" version="1">MYSVIEFKQEEDGGGLSIVNSTWLTPRKTEVCWPPIKDNVQFKKVLRKLEPEIDETWKIYGVQKIFYSTDDFEKATNKLKRAEITSDLQTDLEDDNTRPRRKILKRKFSLDEDSNDQVSLFKPGKKSKQILPWPPPVGINKLYTNPRGSSQELESGTDESDPGIPSGSQFMKSISTPRDKLSFQISTPKSSSSFGRQEATEIQTPTLNESLNFDNSLQDTNGLKVLLKHILTIKEQNRKILNILEKSKPFENSDLPDDFKIKLPIESLQDLEELEIYLTEEENFNTFKSYCASISNLKDVTQKNNRILRSLLTDNIAKHFNYFGNNRRQDRVSNKRPFNQLRLNKVVLDAVKQGTDFTTHEVENAIKRWLKHAPNRNKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4V9</accession>
    <name>A0ABM5K4V9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRANC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505222.1">
        <property type="nucleotide sequence ID" value="XM_050649265.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649265.1">
        <property type="protein sequence ID" value="XP_050505222.1"/>
        <property type="gene ID" value="LOC126883609"/>
    </dbReference>
    <dbReference type="GeneID" id="126883609"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018272">
        <property type="entry name" value="PRANC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09372">
        <property type="entry name" value="PRANC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PRANC" evidence="4">
        <location>
            <begin position="421"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="525" mass="60064" checksum="807F8F17088E883C" modified="2025-10-08" version="1">MEHSMFRRTLPSTFRIWPLHRATKCRSLCDVQQLVEGGALINEMDYDGCTALHIAVHSKLTDIVKYLVEKGADVNAIEVTRGRSPLHYATFNNDLELVRLLTESGANVQYSSTDVDIDMPILFAVEVGNREIVKYYLENGIDVDVKLGKNEMTPLHIAASRGYIKLVDYLLLNNANVHLKDLQNRSSIHHAVISGKVKIVHDIIEKGVNINDGDIFKWTPLYIACRVNYFEIVKLLFKNGAMSNLEERSRNRCPVNLATKMGRLEIVKYFIIGGVDVNGTTEQCTLLHVASRFKQFEIVKYLLENGADVNKKVQGVTPLYVAVDNLCPNVTELLILNGADLKLAEYEGESILWLALEAVRAYEPRNHTVVVKVIIKYTFLIYNFIGDFIPNSWPFFEELTQYCKDCRNEITRMNNVIIKNSTISLYQIICDTNKHNAFIKYLCNDNIKNGIQNIEDCLKDFSIYSNINPLIQLNIKKGIQRMELFKDADLAMKKFVPKLPLEIRWKILDYLDLTEIKNVIQSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K567</accession>
    <name>A0ABM5K567_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505333.1">
        <property type="nucleotide sequence ID" value="XM_050649376.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649376.1">
        <property type="protein sequence ID" value="XP_050505333.1"/>
        <property type="gene ID" value="LOC126883714"/>
    </dbReference>
    <dbReference type="GeneID" id="126883714"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="280" mass="32377" checksum="4627815922D187B6" modified="2025-10-08" version="1">MYGKRAHSDSVVMPPIFDIYRKPIFDESIRKAEYRTYVPFIKSFNCNDIVEFSINQVDSFFAMSETLLCIKRSLEITGNGDVKLANNVGAFLFDSCTYSESAREMETVRDPGIVNAVRAMTCYTQEDSNYMVMAGWNYPKDPILNDTSFNIQMPLKHIFNIFNDYPMITCGRQTIRLVRARNDNDCIVIKEKQNAEKTPTVTTAKINITNIELRVKHIFPNDEIKLELMKSIQQDQPIVIPFRKWELHELPAITKGARREVWAVKTSTSVERPRRAQFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5D1</accession>
    <name>A0ABM5K5D1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505389.1">
        <property type="nucleotide sequence ID" value="XM_050649432.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649432.1">
        <property type="protein sequence ID" value="XP_050505389.1"/>
        <property type="gene ID" value="LOC126883767"/>
    </dbReference>
    <dbReference type="GeneID" id="126883767"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="807"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="944" mass="107205" checksum="7C2E7C5023DCA0C2" modified="2025-10-08" version="1">MALELETKRRTVLRTAFTTAANVLDNLLSETVDTRPWQQISVQWELLQVKYNELCVVESAVFEAMVEKASEAELISEMEAKDRYSTRYYELKYKCEDRPSLVSSESSIKGKRSFKLPPIEFKKYSGDLIDWLPFWSQFKVVHDDPSIDLNDKIAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEEYAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKCKSNNLVEKKNIKLPKQGTDQPSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKNCRARLNCILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLWELDIIGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGFPADPEKCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6U7</accession>
    <name>A0ABM5K6U7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505910.1">
        <property type="nucleotide sequence ID" value="XM_050649953.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649953.1">
        <property type="protein sequence ID" value="XP_050505910.1"/>
        <property type="gene ID" value="LOC114334157"/>
    </dbReference>
    <dbReference type="GeneID" id="114334157"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="912"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1371" mass="155067" checksum="11B8EB1F4E8E1A20" modified="2025-10-08" version="1">MPRTSQKTSHGSSKSLLQHLIHKNGSKTPEKEKALSSSSSSEDISSPYKNSLTKIKTENKDDTDDFKTPIKMFTKMFKQAPSKKGKSNAKRSSKIKNPMIKRTKDNFKNLDVDAEQLQMAIALSKSTFAQEYPEQALENTEPDLPTFLSPNNIPKCTTFLEKYGFKTKRSTLQADVNGEVIRFQETKRPKKSKYRFVTPVLFLRSDKERQDLIDNKVSRLLSEQKENTFKNTNIYSVELNSTFLGDYAEEKKCWQMNCFNDFDAYICPSLELSPTKAAAGYLLKDWENIPGRARSPIPDRVSKEISDDTMECQHSSMKSNEMFITQECSSINQEGSTRSPIPDTGSKEICDDDTTELQHLSMKSNETLIITQKCSSISQEGRTGSLIPDTASKEISDDDTTEFQHSCIKSNETLINQECSLINQEDKMCLDAQSNKESENEYAIDVIVDAEVAMSFKVCNIEQAVQKETHGCDKLDISVNKVDKCISPDLFDSDNDNEDYKSPSKSFSKDKNVTKENLLDSPTDLKDMARDKRSHIGVEESPIKSRYFETSPDNLKMSSLSKDMVQKIRCNLYNKGISCDPPKYSLDVKPLDLTVDTVVLENRSRLNSSERVNDRTQESQDKVYKNDICEEKHFNSCDNSSDKEITMYDIPDGTILENKENPIRDISKASNDSVSESSKQSQRKNLYKNKPYNGEPTKSSIQNISSTKEVFQKEVFDFEVKNSAKNDENVHALSCTESETESTKLSEQLPVYSNNSSLPYSSKDTCKSTTVVLSTNQSPKRSYQKVSCVDLSDDDLTQNVAISSKNNSKSDSFVTKRKKQFAKFYSSEMLDMDLSDSEIPNSVNLSAKSKSVSDDMLGISLHEKKNSSGLRKDAIIDLSQTDSNDSESGPLDAHKGNLSFYEIDLAKTTKEAIGDQDQDTANSGDEFGKPVEGNEEFVDLTQSSDDNTKDSGDVNDKVITEPNPQCRNKKKLEDSSRQSFGTKTYSRDSGNISCEFSSTKSLNVTDYVLGILNLEDDAATENNVKHSEDLPDAEYFSQSHSTCSQGSIEVLDDEELNYSMKFSAQNHKNFYNLTNFDDMCVGHGNEPKDIEAVHLELKNKYCQQNNIDDDHDDNGKEISEEPVSTNRYLEPMETTDLDEPSPTSSKTHVVNDINTETPDKNSKLNYKSTTNTNTTPNGNVIIKTNNITPMANYDAMNSPQIRVELDKFGIKPLKRRRGIQLLKYIYDTTHPFVQDENVEEVSEEEQTREAKRRKLSDKFEKTESINIVGSSLIESEQESDLLFERKFRKTIMSCRVPLQLAWYNFLCCNPSLSQSIVLYEPIQLEVIHSMLKEQSGCNFHVEDLITFLDKKCITFRTNQWQASRKKAKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAB2</accession>
    <name>A0ABM5KAB2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507131.1">
        <property type="nucleotide sequence ID" value="XM_050651174.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651174.1">
        <property type="protein sequence ID" value="XP_050507131.1"/>
        <property type="gene ID" value="LOC126884860"/>
    </dbReference>
    <dbReference type="GeneID" id="126884860"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="68" mass="7918" checksum="1F4298ACEDB60090" modified="2025-10-08" version="1">MTDDEIDQRMETREQRPARILRQSKVNILENVLMKSGKGTEQPQKKTEVEKDTSDAENKVVRSVYIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KB05</accession>
    <name>A0ABM5KB05_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507370.1">
        <property type="nucleotide sequence ID" value="XM_050651413.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651413.1">
        <property type="protein sequence ID" value="XP_050507370.1"/>
        <property type="gene ID" value="LOC114326147"/>
    </dbReference>
    <dbReference type="GeneID" id="114326147"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047394830" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="889"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1397" mass="141538" checksum="90AE6563CF74D930" modified="2025-10-08" version="1">MRSVTVLFAIICAISLATVIAQNADPAVDVADPASSLALASEPCVNDDDVYPPDEPFPDIPANGTTRNGTEVVNQNTTVPQNSEPEGSGNGEQEINGNADNQTDAPQPNDDNTTAENSTDGQTDAPQGNENGAAAENNAQSDAQTDAAQGNGNEAAADNNGSADAAQGNDNRAAAENNANADAQTDAAQGSANEANAENNANADAQNDAAQANDNGAAAENNGNADAAQGTDNEAAAENSGNENGTGAENNANADAQTDAAQGSTNEANAENNANADVQNDAAQANENGAAAENSGNADAAQGTDNGAAAENTGNADPAQGNDNGAAAENSGNENGTAAENNANADVQNDAAQVNDNGAAAENNGNADAAQSNDNGAAAENNTNADAQNGAAQSTANEANAENNANADAQNDAAQANENGAVAKNNGNADAAQGTDNEAAAENSGNENGTGAENNANADVQTDAAQGSTNEANAENNANADVQNDAAQANENGAAAENSGNADAAQGTDNGAAAENTGNADPAQGNDNGAAAENSGNENGTAAENNANADVQNDAAQVNDNGAAAENNGNADAAQSNDNGAAAENNTNADAQNDAAQGTANEANAENNANADAQNDAAQANENGAAAENNGNADAAQGTDNEAAAENSGNENGTGAENNANADAQTDAAQGSTNEANAENNANADVQNDAAQANENGAAAENSGNADAAQGTANEANAENNANADAQNDAAQANENGAAAENSGNADAAQGTDNEATAENSGNADPAQGNDNGAAAENNGNANAAQSNDSEAAAENNGNADAQNDAAQGTANEANAENNANENAQNDAAQANDNEAAAENNGNADAAQSTDNEAAAEISGNADTQNDAAQGNENGAAAENTVDADPAQGNDNGAAAENSGNAEAAQGSDNGAAAENNGNADPAEGNENGSAAENSGNADAAQGNDNGAAAENNTNADTQNDAAQSSANDANAESNADAQNGAAQGNDNGAAAENTENADSQNDAAQNTGNEANAENNANVDVQNDAAQGNESQAAAENNSNADGAQNNNNGPAEENNSNADTQNDAAQGNENGSAAENTGNADSQNDAGQGSANAANADNNANTDAQNGADQGNENGSAAEINGGADGQNENGAAAASSGNADNQNNNNSNNDSGNNQNNGSNSVEENSKEDSGNESQENKDNNDTSEDNSEELDSSEREEEERRKEEEKKQKEEENNNNSVEENSNEDSNNESQEEKDSNDTSEDDSDELDSREQKKKKEEEKKQQKEEEKRRKQEEKRQKQEEKRQKEKEKRKQKEEEKRIKEQQKREEERQRREEERLRREEERKQREEERRRNEDQWIDALKKTIERKLAYLDYIKNQYGINVQCDSEICRCRCLLNNNHSGYCSRTKECVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCG3</accession>
    <name>A0ABM5KCG3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507883.1">
        <property type="nucleotide sequence ID" value="XM_050651926.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651926.1">
        <property type="protein sequence ID" value="XP_050507883.1"/>
        <property type="gene ID" value="LOC114330792"/>
    </dbReference>
    <dbReference type="GeneID" id="114330792"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23550" checksum="18D8E570F38AFD5D" modified="2025-10-08" version="1">MPKRKRIFLSMKNKHEINKRLEGGEPAANLSNEYKVGRLVWFQNRRAKFRKQERLAQQKSSSINSDSPNPTTNIKAENNNSTKNSVSSNKDNVKPGSPHSSISTTPNSNTSSISSLHSNNSDIKPVNGISGKQSEDLISNNNKWSSMSPQSCNTALLVQQANKVLSQPSHLQSHHGSHAAAAAAAALSSPFTSLLGATGGAASYLLGDHLKPATANHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCH3</accession>
    <name>A0ABM5KCH3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507893.1">
        <property type="nucleotide sequence ID" value="XM_050651936.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651936.1">
        <property type="protein sequence ID" value="XP_050507893.1"/>
        <property type="gene ID" value="LOC126885376"/>
    </dbReference>
    <dbReference type="GeneID" id="126885376"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="624" mass="71971" checksum="FF7D1F0A142C0A0F" modified="2025-10-08" version="1">MENENRKKQSPDDLKWEEGMNSFERELINSHKKKQKMNRSTAPKQSTLVGDEMLESSENDDDEIGEERSQEEVEKIEKGWQNIQERVLASFLLDDETMNKKKRKGDSLERINDLKRERLEESIKFPNETKQQKINRKLEELNIKLIEIFTNLSEKKGEKVEMDTELKKLLGVIKSTNNKKEDDSIAEKTQQEVKCDHCKLKVEQERQREEQEKIKRALNMGGGKKTFMSICNSKWEEKAYIKTNWEQGGLQETVEKKTCLIVTKKDAKDKGVENIIKDVGEDLAETLEEVNEGEIKFFENFRRKENKITIWYTFVAGIEKESGGDIYDLAEKAITKIKKEMDETPKVVRVVAGNDLNKEIIRKALEYVGRRESISWEMIVRGKELEVEKKSEQEEALLIKMGGKKYKEVLSEMREKIDIGKIGLQVEKLKRTNGGDLLVKLKGRGAAEKLRAELDSKMNGMDTAIRRKETFFTITRLDPGVGEETLKKMIKSYTGVPEREIEVKVLRTNRYGEQVATIAVRPSIAEELRRYGSIKIGWVVCPIMERHNPVRCFKCLKFGHNTYDCKEESRAACCYNCLQTGHTVASCGNKPYCSVCKEEGHRMDRMACPSYRALVYGRGGEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD10</accession>
    <name>A0ABM5KD10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508074.1">
        <property type="nucleotide sequence ID" value="XM_050652117.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652117.1">
        <property type="protein sequence ID" value="XP_050508074.1"/>
        <property type="gene ID" value="LOC126885535"/>
    </dbReference>
    <dbReference type="GeneID" id="126885535"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="83211" checksum="5562AEB1BF1BA59D" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQSTVATAKVRLPEITMQTFCGSFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFATHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQTPQNSQGASRVVAPISTQHSFNNRSQNEASTSSSRPPLDMQNSPDSQAATSLSALSVKTDVLQLQISTISENTSLSNEMLNLEFFPYNVKDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKIDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFVQSEPEENQLDKLLQQFFEIEEVPLVSKLTPDEELAEQIFSKTTLVLPSGRFQVNLPFVSENANKMLAMVQRSFRLSGMTDAEIWEMLDDIPAAEAEATDVESDYDSDRLMLACNHLHPKMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG66</accession>
    <name>A0ABM5KG66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509189.1">
        <property type="nucleotide sequence ID" value="XM_050653232.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653232.1">
        <property type="protein sequence ID" value="XP_050509189.1"/>
        <property type="gene ID" value="LOC126886346"/>
    </dbReference>
    <dbReference type="GeneID" id="126886346"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="239"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="545" mass="62443" checksum="9DD982B021F35402" modified="2025-10-08" version="1">MFPSQILNSETWWHGPSWIILDSQFWPNEQFKVDHLPELKTQTLLAQNAPDILSFPFDRFSNFSKMCRVTSYIFRFVNNCANRNNRKTGVLTLSELKYSLNALIKVSQNQSFCNEIKDLSNNKYLASKNRLCGLTPFLDRQNILRVGGRLKYSDYNFNKKHPILINGNHHFTKLLFQEQHLILLHGGAQLLLNTIRDIYWPTSGRNLARATVRKCVRCFRFNAKTIQPIMGNLPSARVMPSSPFTITGVDYAGPFLIKDKKGRGCKTTKCYIGLFICFSTKAVHLELISSLSSEAFLQALRRFVSRRGKPEKIFSDNGSNFIGAQRELASLLNAHELRDKLWSLTNSLEIEWQFIPPYSPHFGGLWEAGVKSSKLHLKRVLSKTALIYEEFQTLIIQIEAILNSRPLSPISPDPNDISPLTPAHFLIGKPIIAVPDQDLTDIKVTRLNRYQLLQQMCQSFWARWKTEYISQLQVKGRWKKNQESLTDGALVLIKDDNINPTHWQLGRIFSVHPGRDNINRVATIKTSTGIIKRGFNKICPLPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHF6</accession>
    <name>A0ABM5KHF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hemicentin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509642.1">
        <property type="nucleotide sequence ID" value="XM_050653685.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653685.1">
        <property type="protein sequence ID" value="XP_050509642.1"/>
        <property type="gene ID" value="LOC126886691"/>
    </dbReference>
    <dbReference type="GeneID" id="126886691"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF134">
        <property type="entry name" value="ECHINOID, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411665" description="Hemicentin-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="132"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="232"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="316"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="413"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="504"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="617"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="717"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138059" checksum="637AE4E336669956" modified="2025-10-08" version="1">MDAKGYLTVVFLLVSFVTWAVSEDSSRDTREGEDVTLECRFPPQPSRDTLTYYWAKNNKQTHDNVAIGHVPLDANYKINYRVDKGIYDLSISNASYDRDNGKFECKVKAGGSGTNLHVQKYTLTVLTLPQQPVITPSSYVTVTEGKKQELTCSSIGGSPDPEVKWYRQGSQYPLETALRNGGSRDQPTTATLVINPTKEDDEAVFRCEVWNRALLDDKKLISTMTLSVNYFPRVEIGPENPLRVERDSQATLRCSVDAKPKVTTIRWTRNNRFISSSYNHTIHRVSVQDAGKYTCMADNGLGKVGEQEITLDVLYPPIVTLEAKTKEAEEGESVFIKCNISANPDPITVEWVKDGKPDFRFAGDTLTLSHVTAEHSGTYICRAVNIISPSAPPLRMNEKVGNASIALLVRHHPGRARIMPDKPVATEGSPVTLTCTATPPGWPAPQYRWFRIDPSGQTTILATGTKYTIPSASLVTEGIYHCQATNELGPGELASVSLEVHVPPSFKSKLKPLEIKRVGDSGFVVACSARGKPRPMVKWLKDEEELTPDANMFEVKTDYVETSNGAVSVQSILKFSGKARPNGNELLPSDRGVYSCMFENEVKRTESTMHLKIEHEPIVLHHFNKVAYDLSEHAEVVCKVQAFPKPEFKWFYGANINPLHSSSEGHYVVHSSSDEDIYTSVLKINKIERSDYGEYTCQVINNLGAIDTKIKLQPKGAPEKPSKLASLYDGFNFVTLGWEPGFNGGISNTKYVVYYRKIASDNDIVIEGCNNIPRSVEWNEVDCFQSVPCNVSHLEQYQTYLFKVKAINTKGSSENSQEIRERTRVNKIPQPQSVEFDKNSNTLGINVPATCLPLVAVVETVSNENHPITAWQVIDTMELQVSGLAHTFKEKSLDQMGSKFYNGRALIDEPIGVNDDYVPRIRVKLCLQTHPEHCGEFVDAEFGTGSIREASAMTTPTVIAIVVACIVLILFAGLLLVFCRCRKTESSKKAQSKDYEMDSVQPTIVPQQNQAPPPYYPSSGMDNKALEHSLDLALALEDQKSVYATQNGYGYHVANADIQARQNINNTDWANMGYIENSYSNSNNGGSVNSQDSLWQMKMAAASSNSNNQLQQHHMNVDRQNYGYDPITHGGYGAVDDYAPYPHITTQSNHGDEYIRNSNNPSRQDYCSDPYASVHKPKKRVEIESPYHDVSGLPDPYLEQMEDEKPPQHMSLSYEESLESGYSTPNSRTRRVIREIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHI4</accession>
    <name>A0ABM5KHI4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dual-specificity kinase</fullName>
            <ecNumber evidence="4">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050509650.1">
        <property type="nucleotide sequence ID" value="XM_050653693.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653693.1">
        <property type="protein sequence ID" value="XP_050509650.1"/>
        <property type="gene ID" value="LOC126886698"/>
    </dbReference>
    <dbReference type="GeneID" id="126886698"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="652" mass="72564" checksum="B0A391770D1205B4" modified="2025-10-08" version="1">MYPSTVNKNETVNKSKSCIYDSPCDPKDSDYEKLFCPNNELSEPPKTRCDRLKTGSSCQALKHAVAALHPLDDFHKEKIGEGFFSEVFKVTHQQTGQVMVLKMNTRHSNRRNMLKEIQLMNRLSHPNILRLMGVCVLKAQLHALTEYIDGGSLHQHIHNRSVEIEQETRIEIAKDIACGMEYLHLKGVMHRDLTSKNVLIRRLDTGKLQGIVSDFGLSTDIPDPKEKTKLPIVGSPYWISPEGLNGKYYDESSDVFSYGIVLCELIARVEADPDYLPRTHNFGVDYLAFSDLCGPNVVPELLTLAFRCCSVEPKSRPTFTENVQALADILKDMKLAKEKQQRMANCAAKSEEQLPVLAVQASAPQHRKIVHRRSLSEDTSVWSLSMFATPSDKARRHALLMCRQDPHYKPSTTNPFAGLAQFQGVKKLLGNFSSCCEMPCPFVESKDSPKSLPGSPTASRKAHTIRSPLFVHPLYKGGSSSNLSEFTAESVTGFLRRRGSCESGFYSSVGECLSPNSMWGDSGTAVSSLRSLDELEHAELQALCKRASSIYTDSSEDISSLTSSDWPNDLKPNIQSIVEYFERKGATLRHPGGVRGGLQLSSRIANLRRSLEKHNMGSTSSGAHVTLQRPKCSRLVICEGAVRSKLPLFDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHK3</accession>
    <name>A0ABM5KHK3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509691.1">
        <property type="nucleotide sequence ID" value="XM_050653734.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653734.1">
        <property type="protein sequence ID" value="XP_050509691.1"/>
        <property type="gene ID" value="LOC126886724"/>
    </dbReference>
    <dbReference type="GeneID" id="126886724"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17390">
        <property type="entry name" value="MFS_MFSD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="6"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="407" mass="44853" checksum="0C133E5D48AAC7F5" modified="2025-10-08" version="1">MGTTKTINLIYMISFLDLFAVGLTFPLFGNYLRDLGASHTTVGLISSAYSAIQVLSGPLIGSWSDIRDRRTVLKWTLLMCAACYGLLGTTNSIVFILLLRFVLGVVKHTQSICKAVITDLVSPEEQNDIFGKSASVASLGFIVGPFVGGNLSELNHGFTYVCMLTGLLFIINYVCACYLPENTKGSTPPNSTNNPIGWQTVTSEFKKSVNEIVSIDWKVHWDTFLLKFLLGLTITVYFSNQAIYLRETFQMSQKHVGYMISLFSTIGMISGLCLKKVDSFLKNVDVYTKMGVWFGVLALCFIAMYLSPNFIVFMFFLAPLSLAATAMRVASMELMFKKTEALHRGSLSGASNSVMSVARFMTPLFTGISSDIFSEKSVMLIAVVPASIGVFVSLYTKRKYDSTVKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJA0</accession>
    <name>A0ABM5KJA0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510284.1">
        <property type="nucleotide sequence ID" value="XM_050654327.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654327.1">
        <property type="protein sequence ID" value="XP_050510284.1"/>
        <property type="gene ID" value="LOC126887021"/>
    </dbReference>
    <dbReference type="GeneID" id="126887021"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="276" mass="31947" checksum="AD4F7028A90A9AED" modified="2025-10-08" version="1">MELESSNAINFLDLSITRLNNQFNFGIYRKPTQTDHVIHASSNHPLSHKYSAFRSFIHRLYTIPLSTHEFNKELNIIKQIVVNNDYSPDIIDKLIRKRESNLLRQSAYNSNPTIPPLYRSLPFHNSSISEKIKHILNSSDNINISFKVHNTLGKILSNTKDSIHYMNRSGVYKLSCSDCDATYVGRTFRSLTVRTSEHSKLDNTSAFSHHLKVNKHHLKVPEGVSLIHNIQDKNTLRLDLYEDLEIIKDIRTSPNCVNRQTSLNRDFTPIHRQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLH0</accession>
    <name>A0ABM5KLH0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 62-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511047.1">
        <property type="nucleotide sequence ID" value="XM_050655090.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655090.1">
        <property type="protein sequence ID" value="XP_050511047.1"/>
        <property type="gene ID" value="LOC126887492"/>
    </dbReference>
    <dbReference type="GeneID" id="126887492"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07401">
        <property type="entry name" value="MPP_TMEM62_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041871">
        <property type="entry name" value="MPP_TMEM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="2">
        <location>
            <begin position="314"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="3">
        <location>
            <begin position="441"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="76915" checksum="A5D49BF761C4F683" modified="2025-10-08" version="1">MRITTLTLGVFMSMVLLAIFFAHVVNLLSTAAAPQESNKSTFINVTDSPDHILWFLQVTDIHISIFKDHNRITEFREFCDLTVGAIQPSVVLASGDLTDAKTKDAIGSQQHESEWKYYRDILKETRMRDRTLWLDIRGNHDNFNVAELSSKHNYFTNYSMQGKVHPRSYMYQVKKANAVYTFMGIDACLEPGPKRPFNFIGLLDDIEINEINALIDKTEAGPNNYTIYFGHFPTSCIVTTSDDNVRDILGRHKQGLVYVCGHLHKLGGLIPQMYTLQKAGFLELELGDWMDNRVYRLLAVDHGLLSFKDVYHRSWPIFLITNPKHALFVNPNRENMEVMKNSTHIRILAFSISTIDVVKIKINKEDWMHCKRVKGPLFVAPWNPQKYLHGLHYIEVYVKDSEGRVNSESQPFALDGADLSFGILPKLALMTNASLVFKLFFFVILFLTTLPLFVIRYIHFLVSEGRLVKPKLRKSCWYNCFKKIWILTTVDRIFWPIVVYPIYLAVGPWTVGYLVEDHIGAIFAWGIIVHNSFLPGAFTYAYGFLQLLLFHLPLIFILANAVFIRFREVTLKVGNKQSIRSRVCRHLPFTVIFVIQVITAYLFWLAYGTLAFLLGPLRTWSLILAGVLYYHAMRLPEKCTRKAAEIWYVPSSASLNETNEELSPIQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KM01</accession>
    <name>A0ABM5KM01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cartilage oligomeric matrix protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thrombospondin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511224.1">
        <property type="nucleotide sequence ID" value="XM_050655267.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655267.1">
        <property type="protein sequence ID" value="XP_050511224.1"/>
        <property type="gene ID" value="LOC114330165"/>
    </dbReference>
    <dbReference type="GeneID" id="114330165"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017897">
        <property type="entry name" value="Thrombospondin_3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008859">
        <property type="entry name" value="Thrombospondin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199">
        <property type="entry name" value="THROMBOSPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10199:SF100">
        <property type="entry name" value="THROMBOSPONDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05735">
        <property type="entry name" value="TSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51234">
        <property type="entry name" value="TSP3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51236">
        <property type="entry name" value="TSP_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175551" description="Cartilage oligomeric matrix protein" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="522"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="TSP type-3" evidence="10">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="TSP C-terminal" evidence="14">
        <location>
            <begin position="829"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119954" checksum="F25385E3FF84F079" modified="2025-10-08" version="1">MGCGVGTAIFVFASVILLAESTLFDLGKTKELEGVINDDKFIVSLRHIKPRKRSRGMIETLFAVDFPESNDKFALLLDRKVKKVTVETVENGKKRSQHFKVDSLDEDNSIKSLILEVNQNEPGAHATLYLDCTSYGMVALPKTLREMHKTPDRKLEVHHERKYTIEIDGHHRDLRMVLNRNDCPLSLYTNQSKSYDNYLNDDLNNNLNDDPNIQAQQPDYDQYRRGGEDPYRRTSPGGVPYRGDIPLVSKLEDSGILQALNLLIERVNFEVKRCEASAAAIDNLRRLIEQCELCKAQPIRRPTCATHPPRCFPGVQCYDTEQGPRCGQCPRGYIGDGYSCNPGRKCEDNPCFSGVECRDTAQGAVCGRCPPGYEGDGFSCTRVNPCQYNPCAPGVRCIPQEESPYYRCHGCPAGFTGNGTTCLDIDECDLVQPCDPRVSCHNLRPGYRCDPCPPGFRAEEESQGIGIEEAAQRTQRCIDIDECQTGRACVPHSECINTEGSYHCGACEYGFVGNQSIGCHEGRGYCPSGHRCDDNAECLNLGWGQFGCRCNRGFAGNGVYCARDTDLDRWPDIDLPCDEKYCRKDNCIITPNSGQEDTDGDGIGDACDNDPDNDGITNGDNCPLIANPDQADSDYDGGDKVGDLCDNCPYVKNPDQSDVDGDGKGDACDEDIDNDTILNERDNCKTIPNTDQADRDGDGIGDVCDNCPSAYNPGQEDKDENNVGDVCDSPIDTDKDGVPDNHDNCRLIPNPNQLDTDRDGKGDACDTDIDDDGIPNNRDNCVFVYNPDQLDSNRNGYGDKCDNDTDDDHVTNDKDVCPTNSLIYQTDFSKYQTIVLDPYGETQIDPIWEIYNHGAEIVQTVNSDPGLAVGHDKFTGVDFEGTFFVDSDEDDDYVGFIFSYQSNRKFYAVMWKKHAQVYWEAEPFRAFAEPGIQIKVIDSETGPGEVLRNSLWHTGDTPNQVRLLWKDPKNVGWKEKTSYRWFLIHRPAIGLIRLKIFDGESMVADSGNLFDTTHKGGRLGVLCFSQQMIIWSDLAYRCNENLREEIWRDLSPRYQKKVKIDNIGSYNVKSPDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMA5</accession>
    <name>A0ABM5KMA5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511327.1">
        <property type="nucleotide sequence ID" value="XM_050655370.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655370.1">
        <property type="protein sequence ID" value="XP_050511327.1"/>
        <property type="gene ID" value="LOC126887702"/>
    </dbReference>
    <dbReference type="GeneID" id="126887702"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17718">
        <property type="entry name" value="BRCT_TopBP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17728">
        <property type="entry name" value="BRCT_TopBP1_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049542">
        <property type="entry name" value="TopBP1-like_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049936">
        <property type="entry name" value="TopBP1_BRCT_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21298">
        <property type="entry name" value="TopBP1_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="111"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="200"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="362"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="559"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="651"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1240" mass="139339" checksum="615617E03B947735" modified="2025-10-08" version="1">MDKLRILFVCPQNYADESESSEVMLQAFEVCKQNVNTNVSWIKESKFKSLTLNKTDFVVFEKFEGPLFEELQNTKSTRIVGPWAVSICLTEGKAIPNYEWPMYNVAMYNCIVTCSHLTKNHKMEVRNKVELMGGCYVDNLVEKNTHLVTGSAKSEKYLIAAEAGLKLMRPTWIDDVWTASQTANVHADDEDFQKHKCLTFHNLTISSTGITNLAEKLKIEKLVTENGGNFSGKLTLATTDVLVCSGDVVKSEKYKAARQCEHIKCVNVNWVTDSVAKGYALSHDLYKVQKITSTPTKRDKYVNPEFSVLSAIGGFNTSSRTHIEETLSMTSSDGERVSNNKRKAKDNLDELIESLDIKKAKKSGEYLDGCSVYLTGFGSEHIDKLNKIINLSGATRYDTFSDRVTHVIVGDSSSHEVAIIKNKNSSAVLVSLQWLIDSMEQKQPVVEDKYLVVTVDVDVNLGSPLSKKGLSLLRSNRTVTEKEIELNNMNEEEMDNDFTPQSMAPPNESDTLGMLLNGIDGTKLIKEIQEPPKCTPQFQPTEASTQQSSMSVTQDAETEVSRIFEHSKFLIVGFDDEEFAELKKSITDLGGDVVSKSYKGIPDYAVVPMFNKNELHHTASEIVNELFIRECIKQEELLLSIDYYHRPVDIPDTKPVEDCVITISSYSGTERNFLRHLIEALGGLAQEQFARVRSENKGLFASTHLVSFEASGKKYEAALKWGLPVISKDWLLECAKTGKKVYEGDFLLGESTAPDRREEYVENTPQKCKVPNDTAKVYVTPSDLAGSSKSSKVLTPVNNVTPYHKRFLNSAEKFSQVTPVNKIMKQFRESNLNFSQSNKETKEYSIPQPWAFVKTPETPLGAFLKPDPSPNLKKQFEYWLGQFPDKPSPKSNKSTPLSEIKRQLAEKVAKIGAYKLNFDETGEDLPEQRLQQQQLDTTDTNSEVTPNEADITPENQQIASRIKQIEDLLSASGSAKRQSTNFQALIPGPAGTSEYKDSQPCTVGWDFRSQEHQQAKSQLKIFSLSGIADDTERAKMVTDLEQLGATVSNLANYDPSCTHLLCPKPARNEKSLSCMASGKWILHTSYLEKSIEAGHFLNEEEFEFGNPKSVGKFTISHDRDTETRTQQMHWWRKEVGRRGYGAFNDMRAIVVANKREPIIRVIEAGGGVVINLKPPFEDTVHATHCLLEQKSVDKFTDYIPLAKQGIYLVNTVYISDHLHNPNKDIRDCILPYFSKYYGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMI9</accession>
    <name>A0ABM5KMI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050511404.1">
        <property type="nucleotide sequence ID" value="XM_050655447.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655447.1">
        <property type="protein sequence ID" value="XP_050511404.1"/>
        <property type="gene ID" value="LOC126887730"/>
    </dbReference>
    <dbReference type="GeneID" id="126887730"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20897" checksum="F7C3C2B8AE4C86D1" modified="2025-10-08" version="1">MRVHTEEKPHKCEICLKQFATANQLKVHLRVHTGEKPYKCEICFKVFSRIDVLKTHLRMHTGDKPHKCEMCFKQFSEAGHLKTHLRVHTGEKSHKCEICFKQFTIASNLKTHLRVHTGEKPHKCDICFKQFTTVNQLKLHLRVHTGEKPYKCENCFKEFSRNDILKTHLKTHTRKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KN16</accession>
    <name>A0ABM5KN16_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511563.1">
        <property type="nucleotide sequence ID" value="XM_050655606.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655606.1">
        <property type="protein sequence ID" value="XP_050511563.1"/>
        <property type="gene ID" value="LOC126887789"/>
    </dbReference>
    <dbReference type="GeneID" id="126887789"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="24286" checksum="340B5800CF25A506" modified="2025-10-08" version="1">MFSLLFITMTELNELGRLITELLSEDEELEDSGDSYSPSSESLSDENEEITDRRPRNKAKKRVPADISTTATKSKPALMPIDLPSTSTAGAHQTTSNDEVHLPINPVGEEVIIDQVTNTKPPPVKRRKRDVSSWKSQKRYISHQKGESYVSRRGIVEPAKEVKSLKDCLNDCKFKCGVSISENERQALFKAFYGMNQNGKHQYLGYNHRISVRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPH4</accession>
    <name>A0ABM5KPH4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="9">4.1.2.63</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-hydroxyoctadecanoyl-CoA = heptadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55196"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
            <dbReference type="ChEBI" id="CHEBI:138631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="9"/>
    <dbReference type="RefSeq" id="XP_050512095.1">
        <property type="nucleotide sequence ID" value="XM_050656138.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656138.1">
        <property type="protein sequence ID" value="XP_050512095.1"/>
        <property type="gene ID" value="LOC126888127"/>
    </dbReference>
    <dbReference type="GeneID" id="126888127"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="193"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="390"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="571" mass="62372" checksum="A32D557F507FF493" modified="2025-10-08" version="1">MGDLDGNTVLAQALKKQGIEYVFGIIGYPVIELSMALQMADIHYIGMRNEQAACYAAQAIGYLTGNPGAVLVVSGPGLLHTFGGLANAQINCWPVLVLGGSAPQDHEGIGGFQECNQVELARPYCKYSARPPSIPLIPLHVEKAVRLAKTGRPGAAYLDFPANILSGRVSQEKIPDQYGPVPIPQVFPDPRQIEKVITVLSQAQNPLIIVGKGAAYSRAEKEVRDLIEFANLPFLATPMGKGVVPDTSTKFVGSARSTALQQADVILLLGARLNWILHFGRPPRFSPNVKVIQIDITAEELHNSVKSEVAIQSDIKSALELINAGLKKRNFKYNDNSEWWSLLRKKCRDNQRTVKAMCADISVPLNYYAVFQNLFDHLPEDCIIVSEGANTMDIGRTLLLNNQPRHRLDAGTFGTMGVGPGFAIAAAFYCRHNQPNKRVICVEGDSAFGFSGMEIETMVRYKLPVIIVIVNNSGIYSGMEATVLNEIRDSVGVEEIAKVSPPGCLTSVTRYDNMMSLFGRTGFFVNTIPELHAAVKEALNVIDGPTIINVIIDTTADRKPQSFHWLTESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRQ8</accession>
    <name>A0ABM5KRQ8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512873.1">
        <property type="nucleotide sequence ID" value="XM_050656916.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656916.1">
        <property type="protein sequence ID" value="XP_050512873.1"/>
        <property type="gene ID" value="LOC114328338"/>
    </dbReference>
    <dbReference type="GeneID" id="114328338"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF7">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="250" mass="27625" checksum="CD4864423D950C30" modified="2025-10-08" version="1">MYENRSRFKSYINKLAVTKAEGDEKVILLNLKYSSYDTLPSPASHNSVFYSPQHDPRNSVGLPLSPAGLGVVDSSVSSPSTPSRQPPPYRAPPPPPSSASMNSLDTMSLGSTTSLNDLQKTPQPPPREKRKDSENRNFQEDGTPQKTDVDDPNVEDKTISVKERTQKFNRLASVDDELSPRPPKSAEKKSRGADEDDGVSLTPIDPKKCVEWYVTASRGDYQELLKLANTEPRLVNKKVTLTLEMVLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUF1</accession>
    <name>A0ABM5KUF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513820.1">
        <property type="nucleotide sequence ID" value="XM_050657863.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657863.1">
        <property type="protein sequence ID" value="XP_050513820.1"/>
        <property type="gene ID" value="LOC126889522"/>
    </dbReference>
    <dbReference type="GeneID" id="126889522"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="234"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="300" mass="34162" checksum="A989CF6CC1405FEF" modified="2025-10-08" version="1">MSFVITTKEMEYQLPAPPISTTTPAPLGHQVPVGVMQGTLTHVQTTQQDESHRWTQYQQLWRQHVYMNGNSKPPHPHSHGHTTIKDLTGNILGDDKTKDDGELWNTVEAQTAFLGPNLWDKTYETDLKYVDLDEFLSENGVSMDGLGSHGSLGPLNSSQPLPKRERSPSPSDCMSPDTMNPPSPADSNFSEALSMASSCRDFDPRKKVFSDEDLKPQPLIKKSRKQFVPDDLKDDKYWARRRKNNLAAKRSRDARRMKENQIALRAGYLEKENVGLRQELERMKKENLILKNKLSKYEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW80</accession>
    <name>A0ABM5KW80_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514446.1">
        <property type="nucleotide sequence ID" value="XM_050658489.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514447.1">
        <property type="nucleotide sequence ID" value="XM_050658490.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658489.1">
        <property type="protein sequence ID" value="XP_050514446.1"/>
        <property type="gene ID" value="LOC126889818"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658490.1">
        <property type="protein sequence ID" value="XP_050514447.1"/>
        <property type="gene ID" value="LOC126889818"/>
    </dbReference>
    <dbReference type="GeneID" id="126889818"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028536" description="Spondin-1" evidence="13">
        <location>
            <begin position="20"/>
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</entry>
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        </source>
    </evidence>
    <sequence length="1115" mass="130351" checksum="C2AC504D51B1030B" modified="2025-10-08" version="1">MAQAQLELEMVHEFVPRGLCTGYSQEENKMKIMETLHSRHKGKSTGRLVEGKILNKNLKVATKYKPYKCEICFKPVITTSDLKRHLIVHTGEKLYKCEICFKWFGEAGDLKKHLTTHTTEKPYKCDICFKKFSLKGMLTGHMKVHSGENPHKCEICLKLCSTTSDLKSHLRIHTGEKPYKCEICFKAFARGSELKIHLRVHTGEKPYKCEICLKWFSETGSLKKHLTTHTKEKPYKCDICLKAFARTTLLKEHLLTHTTEKPYKCDICFKKFSRKGLLTGHMKVHSEENPHRCEICLQQCSNASNLKTHLRIHTGEKPYKCEICFKAFARECNLKIHLRVHTGEKPYKCEICSKWFSETSSLKKHLTTHTKEKPYKCDICFKAYTRGSDLKIHLRVHTGEKPYKCEICLKWFSEIGSLKKHLTTHTKEKPYKCDICLKGFARTTHLKEHLLTHTTEKPYKCDICFKKFSRKRLLTGHMKVHSEENPHRCEICLQQCSYASNLKTHLRIHTGEKPYKCEICFKAFARECNLKIHLRVHTGEKPYKCEICLKWFSETSSLKKHLTTHTKEKPYKCDICFKAFARGSDLKIHLRVHTVEKPYKCEICLKWFSEIGSLKKHLTTHTKEKPYKCDICLKAFARTTNLKQHLRTHTRQKSCYSQEENKMKIMETLHSRHKGKSTGRYVEGKILNKNMKVATKYKPYKCEICFRPFITSDLKKHLRVHTGEKLYKCEICFKQFGEAGDLKKHLTTHTTEKPYKCDICFKKFSRKGLLTGHMKVHSVENPHKCEICLQQCSNARNLRIHTGEKPYKCEICFKAFATQSYLQIHLRVHTGEKPYKCEICFKQFNQATNLKTHLRIHTGEKPYKCEICFKAFARGCDLKMHLRVHTGEKPYKCEICLKWFSETGSLKKHLTTHTSEKPYKCDICLKAFASTTHLKRHLLTHTTEKPYKCDICCKIFSRKGLLTGHMKVHSGENPHKCEICLQQCSNASNLKTHLRVHTGEKPYKCEICFKQFNQATNLKTHLRIHTGEKPYKCEICFKAFARESDLKVHLRVHTGEKPYKCEVCLKWFRVTGSLKKHLTTHTKEKPYKCDICLKAFARTTNLKQHLRTHTREKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXP1</accession>
    <name>A0ABM5KXP1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514959.1">
        <property type="nucleotide sequence ID" value="XM_050659002.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659002.1">
        <property type="protein sequence ID" value="XP_050514959.1"/>
        <property type="gene ID" value="LOC126890152"/>
    </dbReference>
    <dbReference type="GeneID" id="126890152"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31782" checksum="77D0B23A7D702047" modified="2025-10-08" version="1">MIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEESAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKYKSNNLVEKKNIKLPKQGTDQPSATAAGLINYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVLHSSKKCRARLNCILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRSEDQTLANLNITQVFLQTLRVNIRSAHGTKQVRALVDTGSQRTYILQRTAQEMGFSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY12</accession>
    <name>A0ABM5KY12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515083.1">
        <property type="nucleotide sequence ID" value="XM_050659126.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659126.1">
        <property type="protein sequence ID" value="XP_050515083.1"/>
        <property type="gene ID" value="LOC126890268"/>
    </dbReference>
    <dbReference type="GeneID" id="126890268"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="1">
        <location>
            <begin position="72"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="290" mass="34433" checksum="6F5937157D291B9B" modified="2025-10-08" version="1">MSARARALSITCFKNPKQDLLNFKDPALWQDSHNYAEMILEKWVEQNLTDMDFSMSKRNFGEQHRYAGKQIFYKRLVNGEVVRRDWAIYSESTGNIFCLYCVLFGNKKNQFKTGFSLWNKSKERLDEHERSNDHIDNLKMYMTRLLKQGRVDVELEKEISTAKEYWVKVLEIIISVIKFLATRELAFRGTHERIGEKRNGNYLGLLELLQSKLEIIRRSDSYKSYSRAFEFLFKLKATEDEDIFRLATELQQNYKEDLDEYFPQECVHLNHLLTSLPQLKIDTALELMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY35</accession>
    <name>A0ABM5KY35_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515106.1">
        <property type="nucleotide sequence ID" value="XM_050659149.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659149.1">
        <property type="protein sequence ID" value="XP_050515106.1"/>
        <property type="gene ID" value="LOC126890291"/>
    </dbReference>
    <dbReference type="GeneID" id="126890291"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="205"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="413" mass="47705" checksum="BDADC867F8FBE09F" modified="2025-10-08" version="1">MWCPWENSALEIVENNEVEIVEENEEILPPNNPENAAGPSRGSIKKPERKHLSKDAKEIVLNVFNGLCEELERHESVLKTAALTKVSCATVYRIIKEGITNRQKRSDFGLHRSIEQHILGPISETIYNMFAGNIIPTLNQILAELKSKNIINCCKSTLRKFLLSNGFKYKTINKRHTITESARLIKWRNEYLEKITEYRNSGRKIYYLDETWFNTNETIGKGWSNDNVKCKVNVPPSRGKRICILHCGGKDGWVTDSLLLSAKDIKDSCLDYHQDITGELFESWFKNNLLPNLADNSVIVLDNASYHSRQLKKIPNKYSRKDELQDFLLSQDLYFEDWYTKDQLVEVLNTKLFVKEYIIDNAASKNGHTTLRLPPYYCVLNPIELLWSQLKYNVRQKNVCSGMYRKEGQCEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L142</accession>
    <name>A0ABM5L142_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516151.1">
        <property type="nucleotide sequence ID" value="XM_050660194.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660194.1">
        <property type="protein sequence ID" value="XP_050516151.1"/>
        <property type="gene ID" value="LOC126891015"/>
    </dbReference>
    <dbReference type="GeneID" id="126891015"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="268" mass="31164" checksum="2D6ADC9D3419800C" modified="2025-10-08" version="1">MNTEPELNDLVLKHMMHGPCGIGDPTCSCMRNDDNTCSKKYPKEFRETTIPNIGRYAQYRRRNNGRSGKVKRGQRIYEDMTNQDVVPYNPWLLKKYNCHLNVELVNTTSACKYIFKYISKGSDTAVMNVVQSTRNTTETTNTTDADDTNKKYDEITEHIESKYLSSCEAAWRIFELPLIDKTQKIEKLPIHLEGERSVVFREGDEQAAIENAEGKFSKLEAYFILNREDEQANNIKYRNIPMYYWWNASAHKWVRRVYDKGSAKSPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1N4</accession>
    <name>A0ABM5L1N4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516348.1">
        <property type="nucleotide sequence ID" value="XM_050660391.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660391.1">
        <property type="protein sequence ID" value="XP_050516348.1"/>
        <property type="gene ID" value="LOC126891209"/>
    </dbReference>
    <dbReference type="GeneID" id="126891209"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="458" mass="52283" checksum="740E0C0A8700E36D" modified="2025-10-08" version="1">MALVEFQERYNLPVTGTLNTDTMNMMNKPRCSVGDNNYAIHSKWNKTTLSWYFPQAVSNPVYIHLAEDAFVRWEKISNLKFKRVIIPSSKPDITITVVSNNHNFRASCQGTSKCPLNFDGPGKVLAHAYYPGVNDCIEIHLDANERWYAGNGAAPDGEANFLAVLLHEIGHTLGLEHSNSDSSIMYPWYQHDVTSFGDDDKKAISMLYGQTEAPTSMSTAPVTQTTLSKNRIYLPTTPAIKNICLLQYPDFMFLATSPQFPNYRMYVGSDKYLWKFDLNEMRLSQHPELITDYLPKELRFTQVSHVFQNSEGHLITVSNNRYYDASFPNLQLQKSFMFPSIPTRTKINALFQTNSGQTYLLYNDNSYIEFNEAGDVLNRGPINDLFPGIPNKITSAFRYTDGFIYFFQNNTYYKYSEYTRKVVAAGTFSWGLFGIPCPEDGLLKQLKTLLNKIVTIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3L8</accession>
    <name>A0ABM5L3L8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517037.1">
        <property type="nucleotide sequence ID" value="XM_050661080.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661080.1">
        <property type="protein sequence ID" value="XP_050517037.1"/>
        <property type="gene ID" value="LOC126891801"/>
    </dbReference>
    <dbReference type="GeneID" id="126891801"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="266" mass="30355" checksum="A8FD93E141EE1A62" modified="2025-10-08" version="1">MEWSEENIIKLINSYRGKCLLWDPKHKDHFKKPLKADAWREIEREIRIPADQCKKKVICLLSSYRREKSKIKTSKGTGTGTDEVYVSRWFAYEALKFLDDRDVPRKRLTTETEHIMENVDEIEAEVSLSAQSQETSAPSSIDIPPKRSKRADEPSSSMMSNAFNILQNAADKLDTLKEKPNEINTFFTYAATKVINYSKETQTAVQQAVFEILMKADRGVYDSASSHHQHSWQNPPVNMTPSLPSPSSQSSYTSMANISNPPESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3V4</accession>
    <name>A0ABM5L3V4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517131.1">
        <property type="nucleotide sequence ID" value="XM_050661174.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661174.1">
        <property type="protein sequence ID" value="XP_050517131.1"/>
        <property type="gene ID" value="LOC126891843"/>
    </dbReference>
    <dbReference type="GeneID" id="126891843"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF79">
        <property type="entry name" value="NA[+]-DEPENDENT INORGANIC PHOSPHATE COTRANSPORTER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="525" mass="58728" checksum="D7D4296E22459A81" modified="2025-10-08" version="1">MSNEEASEIENKDPGQCCSCRDILWYVVFAGFAVNYMVRMNLNIVIVSMVAPKPKDNISITSECIAQDPLKRNLGTPLLLNQTNSTSEKMPNSTLTKPNLEEQYFDWNEYDISLILGSFFWFHWTTQIPGGVLATKFGTKRVFGFSNFIGVALNFVIPWLAHRGAIPLIILRSLQGLCLGVSWPSMHNLVSKWIPPNSRSNFISAYMGSSVGIAITYPLCGLIIERWGWEAAFYSCGVIGTVWFLVWWYLVYDSPSEHPRITPEEKKYIITSIGKNLSDKKLSIPWKAIFTDRTVWASFIVYLGTGWSLYTLMVNMPTYFKFIHGWDIRSTGFISGMPHLCRLLFAYTFSMFGDFLLRKEKISRTNLRKLATVCSNGLEGVCMIALAYVGCHKIAAVVISAVAVIFHGAITTGVLAGQVDRCPNYSAIFLGITNAGATLIGFFSTMVVGLFTFQNQSTAQWQKVFWLCAVILFSSCLFYVLFASAEVAAWNNPSESLPEAKKLVSNSKTGNNKDRKGNNESENTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L579</accession>
    <name>A0ABM5L579_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517596.1">
        <property type="nucleotide sequence ID" value="XM_050661639.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661639.1">
        <property type="protein sequence ID" value="XP_050517596.1"/>
        <property type="gene ID" value="LOC126892170"/>
    </dbReference>
    <dbReference type="GeneID" id="126892170"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16647" checksum="A630B9A11D9EC495" modified="2025-10-08" version="1">MENVDEIEAEVSLSAQSQETSAPSSIDIPPKRSKRADEPSSSMMSNAFNILQNAADKLDTLKEKPNEINTFFTYAATKVINYSKETQTAVQQAVFEILMKADRGVYDSASSHHQHSWQNPPVNMTPSLPSPSSQSSYTSMSNISNPPESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5A4</accession>
    <name>A0ABM5L5A4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517622.1">
        <property type="nucleotide sequence ID" value="XM_050661665.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661665.1">
        <property type="protein sequence ID" value="XP_050517622.1"/>
        <property type="gene ID" value="LOC126892184"/>
    </dbReference>
    <dbReference type="GeneID" id="126892184"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46775" checksum="5A0E3EF4B1200BA3" modified="2025-10-08" version="1">MTSAAFKGLTLSRGLEICRAAEVAARQLSVISGANSSQSLEVLEIQKQKKHQSNRNQQPKSAPQYTADPGQSYRNHPQTSGNQKISNNFIKNCYKCGSNHSLNKCPAYGLRCKICNKFNHFAKVCNANSYRNRVHNVNVHQSDTDSDSDFSPDQFFLNNINEKSSEKWYEDCFINNKIIVSFRLDSGADCCVLPYTYFKKLNIQTSELTSSTNKITDYNGKIINTVGSVYLKVRQCKNKENIAKLKFYIVKTHNDAILGLDACIMLNLIQKNNINVINDNLHNDIESISQIIHEYDDAFRGVGCLKGKHTIKIDEKVAPRVHPPRKVPFAMHDKLMEKLKELERLEIIRKVTEPTDWRMLNYYLRKGDVMMTSFRWLAFARNCLFNKVKKREEEGAPLSDVNLNHVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5M1</accession>
    <name>A0ABM5L5M1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 70 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517734.1">
        <property type="nucleotide sequence ID" value="XM_050661777.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661777.1">
        <property type="protein sequence ID" value="XP_050517734.1"/>
        <property type="gene ID" value="LOC126892264"/>
    </dbReference>
    <dbReference type="GeneID" id="126892264"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25410" checksum="563C0D48C70A0D68" modified="2025-10-08" version="1">MSIKSCIRVIPLLRNAINSHNSCLSRTINFTKSNIHRSTFSLYNKLDIRLYSTENKSESKEIYYGSLTPQIKAVKIFSLSSSVVGIIAQPFLYNEIASTGNVPVIVAAYTAIGFFTVVTPILLHLITKKYVTHLYYKPSTNSYIANNVNFFCLTKETEFTPEDVVVSEVPGMFTTFEAKGKALFVDPRLFEDPEHYAKIMGFDKPLDFKLYQTTDNIPSSSNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5Q5</accession>
    <name>A0ABM5L5Q5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517769.1">
        <property type="nucleotide sequence ID" value="XM_050661812.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661812.1">
        <property type="protein sequence ID" value="XP_050517769.1"/>
        <property type="gene ID" value="LOC126892312"/>
    </dbReference>
    <dbReference type="GeneID" id="126892312"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="208" mass="22803" checksum="9FA90E284737DFC6" modified="2025-10-08" version="1">MMDSTSANNSASVLQDNSASVDRISVKIPPFCPNDPEIRFLQVENQFTLANITSDATKFNYIVANLETVYISKVRDIIVSPPATERYVKLKSELIKRLSASQKQKIKRLLEHEELGDRRPSQFLRHLQSLAGTKVPDNIVKSLWLGRLSSSTQAILATQAKASLDAVAELADTISEAIAPSVHISEASNARESTIDKLTAELAGIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5W2</accession>
    <name>A0ABM5L5W2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517826.1">
        <property type="nucleotide sequence ID" value="XM_050661869.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661869.1">
        <property type="protein sequence ID" value="XP_050517826.1"/>
        <property type="gene ID" value="LOC126892346"/>
    </dbReference>
    <dbReference type="GeneID" id="126892346"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="206" mass="24258" checksum="65A41FF2C0E3CBA4" modified="2025-10-08" version="1">MRIHTGERPYKCEICSKLFTENSSLKVHMRIHTGERHYKCEICSKLFTKNSSLKVHIMRIHTGERPYKCEICRKQFTIKRNLSEHMRVHTGEKAYKCDICSKHFNQRSHLNAHMKIHTGEKPYTCEICSKLFTENSSLKLHMRIHTGERPYKCEICSEQFSRLSILKQHMSVDTGKLYKCANCSKQFSRKSGLNRHVKVHSGEKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L635</accession>
    <name>A0ABM5L635_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517899.1">
        <property type="nucleotide sequence ID" value="XM_050661942.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661942.1">
        <property type="protein sequence ID" value="XP_050517899.1"/>
        <property type="gene ID" value="LOC126892413"/>
    </dbReference>
    <dbReference type="GeneID" id="126892413"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="117"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41704" checksum="9247FA8797464444" modified="2025-10-08" version="1">MVVSKFFYECPAPILNGYYVKLPPKYRKKIQIIDKPFHQWNDYCSHCDSSTGDSYHSLMYLFKISVSSISRIIPEVCKVIAEVLKDKLKMPQSREEWLITGHQFANLWNFPKCAGVMDGKHIMIQAPKRSGSEFYNYKSFFSVVLFIVANANYEVMYLNVGSQGRISDGGVFDSTHFKKMLYQNTLNLPELEPLPGRTKAVPFVFLGDDAFPLSPNLLKPYPGTQEKGSSKRIFNYRLSRARRISENVFGIMSARFRVLRKPMLLEPDRVELVVAACVYLHNFLRSSLHSRKSYSPPGTFDSEDKDTGERIPGSWRNEINNNMFASLQKQARNSTLEAKQVRDEFAQYFMSPEGMVPWQNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L668</accession>
    <name>A0ABM5L668_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517937.1">
        <property type="nucleotide sequence ID" value="XM_050661980.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661980.1">
        <property type="protein sequence ID" value="XP_050517937.1"/>
        <property type="gene ID" value="LOC126892446"/>
    </dbReference>
    <dbReference type="GeneID" id="126892446"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="544"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="657" mass="76712" checksum="1007392BB4822D80" modified="2025-10-08" version="1">MPKPQYRQHFRDSWLQDPHLKDWLQVIESTTGQEAKCKFCGTTLRSHYGDLKSHGMSKKHQQNKKVITTQPKIPFKPEPIGSKKKQEARLALFTAMHTSIRVVDHLGEVYNNNHEKDIEKVQLHRTKCTSIIKNVLALHFTEVLKKDFKDQPFSLIIDESTDITVHKYLGLIIIYYSKLHQKIVSTFLDLVNIHECNAEGIVSTIKKTIKRFDLRLENLMGIGTDNASVMVGVNNGVYAKLKEEVPHLILVRCLCHSLQLAVSAAAKEFLPRNLEFLIRETYDWFSRSSSRQSLYKKLYETINDGQKPLKIVQACQTRWLSIESAVSRIYTQWLELKTHFSIAKVHERCHTAELLHSMYANEMNYAYISFLYPILIEINRVNKMFESTDTDHTKLCEELINLINMLVNKVTLPTNKFNIFTQNIRDFLDKKCYLGFRFHNQILEMREKGLPREDEEMMRHRCMTFIVNLIEEIKNRLPENLTLMKKISRISVEQALNHNKEPLTDIMAQFNKSAEHIARVDDQWHQIHLLKWNETKNTKKFWNEVLHFKDAQGESRFEELATFAFTLLILPHSNADVERLFSSMNVIKNKQRNRIKLNLLTAILRVRCGLRLEGKCCNDYEIPVSVIKQIGTKESYQSETEDDGADINDSSEEEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8C2</accession>
    <name>A0ABM5L8C2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518685.1">
        <property type="nucleotide sequence ID" value="XM_050662728.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662728.1">
        <property type="protein sequence ID" value="XP_050518685.1"/>
        <property type="gene ID" value="LOC126892896"/>
    </dbReference>
    <dbReference type="GeneID" id="126892896"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="160" mass="17508" checksum="75D997207CB5EAA1" modified="2025-10-08" version="1">MVTAFQKGLNTTGPNIKGLAKKVTFSKKIQPIQLPEQDYEVPAGTKVTTAGWGKTEHRVNYTPFLLEISTKIIDSQTCEKLFSSTKGVKVTERNICAENFKEKKVACGGDSGGPLELNGTLIGVVSWGDCNSPAEVVEKYTTVFSDVRDFIPWIKKHAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9Z2</accession>
    <name>A0ABM5L9Z2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519261.1">
        <property type="nucleotide sequence ID" value="XM_050663304.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663304.1">
        <property type="protein sequence ID" value="XP_050519261.1"/>
        <property type="gene ID" value="LOC126893282"/>
    </dbReference>
    <dbReference type="GeneID" id="126893282"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="54890" checksum="77B94A9DB02237B4" modified="2025-10-08" version="1">MATYISTKRGQKKLIFQEYFYHRVRSTPNGRTYWTCGESCGGSAITIGDGNDGENVIIRRVHNHGPSHKIGPMTVQHKIREAASSSHYTPRDVVNTALEGISDDTKVHLPQLTSMQKMVRKVRRRNQVIPRVPHSFRELIIPNELRRTKTSIPQDFILSDTGIDDQNRIIIFGCTLDLTRLIQCDTWVVDGTFKSAPNLWYQLWIIHGVFHNKTLPFIYAFLPNKNERSYERSLIKIFEKIDIIRPGARPNTIVIDFEMAVVNTFRRLVPNIRVHGCFFHFCQAIWRKVQQLGLAQLYRDEQFFKTLIKSFCALSFVPPAEVSQVFELLETELIDSFGEDERCHSFIDYFITTWVGRTLPPRNPYYAIGMWNCNNITLEGLPRTTNSAESFHHAFNSMFSCRHPNPYILIEKLIKEQLRQDLISSRLEAGLEEVQDNRYQRANGRLANLLRNYNNMNVGQFLEECGQHITYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZA5</accession>
    <name>A0A6P7EZA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rab5 GDP/GTP exchange factor isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114324317</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127922.1">
        <property type="nucleotide sequence ID" value="XM_028272121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZA5"/>
    <dbReference type="FunCoup" id="A0A6P7EZA5">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272121.2">
        <property type="protein sequence ID" value="XP_028127922.1"/>
        <property type="gene ID" value="LOC114324317"/>
    </dbReference>
    <dbReference type="GeneID" id="114324317"/>
    <dbReference type="KEGG" id="dvv:114324317"/>
    <dbReference type="CTD" id="38144"/>
    <dbReference type="InParanoid" id="A0A6P7EZA5"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="226"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028127922.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="80412" checksum="AE3F369D0EC9E8D6" modified="2020-12-02" version="1">MPVLTLQRSYKYIMYATKQPSLRIKQADLKCKSGCGFYGNADWNGYCSACYRNHMDIERQKKTTDQSRSQVPGFSKFEEKKRQQTDKKNKYLKSLPVFRKSSNVKDAGRPEKYIDIMRQTNPDANKLMVEFISMYSQWGELVRKDFFKFSQVFSNKIVNELDVKPIEELAEIAQNHYNLYHNRVNSNVIYQDVPSEVREKLVEFFEKYSMISLYSFLFCPPTTNDEEKDLIIQDRIRKLSWVNAHHLDCCISETSIEVRDLVYTAINDLLGMDSMKAPQEKLACVVKCCRSVVEVLQHCQGGPVSADEFLPALIFVVLKANPARLKSNILYVTRFCKDSRLMQGEAGYYFTNLCCAVSFIENLTAESLNMPQQEFEAYMSGELTGVSAWESALVACEGMHQLCEHLSLLKGLSERTTTVQNTTQKLREDMQRLKEEICENVVAVLARTPMIIKPRKTPLTLTTLTREKLKPTSSSAITSSISQKETQPEEDLNLQKNYYLQNLSLSQINALDSTRNKLQLDITPCITLPSSTNLTKKTYSNELLLQSPAQDKSFESITPDDNSYLGLSKVNYDIDFSDLSTENSMAEDLTPDKRKSPTPGYVSSDPFSPVGLSCPITQSPLIPSNVSFSQIEPKIMKTDSFVLPFLEEAKSEESLLDKLEETSSVNLPPPIKPTTSEYSGFSKQGSKIPSIPCNTGDFSSLNISGGPSKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6R7</accession>
    <name>A0A6P7F6R7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partner of Y14 and mago</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114327141</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131459.1">
        <property type="nucleotide sequence ID" value="XM_028275658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6R7"/>
    <dbReference type="FunCoup" id="A0A6P7F6R7">
        <property type="interactions" value="1298"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275658.2">
        <property type="protein sequence ID" value="XP_028131459.1"/>
        <property type="gene ID" value="LOC114327141"/>
    </dbReference>
    <dbReference type="GeneID" id="114327141"/>
    <dbReference type="KEGG" id="dvv:114327141"/>
    <dbReference type="CTD" id="37780"/>
    <dbReference type="InParanoid" id="A0A6P7F6R7"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028131459.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21846" checksum="5F8DE13E9B2167AD" modified="2020-12-02" version="1">MSLANNNVVAENGEQYIPATQRPDGTWRKARRVKEGYVPQEEVPLYESKGKQILNRKNEPVVLASGQVAKKATIPGLYIVEDEVEKKKKPKKKMEEVEKLISNIKISEPPKQKSAKPAKKDPKPAQDTNAQEATTDPQKKLKNLKKRLREVESLEEKIKNGTLAKPEPEQLVKVKRKNDLIVLIHELEKMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8Z6</accession>
    <name>A0A6P7F8Z6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114327770</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132279.1">
        <property type="nucleotide sequence ID" value="XM_028276478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8Z6"/>
    <dbReference type="FunCoup" id="A0A6P7F8Z6">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276478.2">
        <property type="protein sequence ID" value="XP_028132279.1"/>
        <property type="gene ID" value="LOC114327770"/>
    </dbReference>
    <dbReference type="GeneID" id="114327770"/>
    <dbReference type="KEGG" id="dvv:114327770"/>
    <dbReference type="InParanoid" id="A0A6P7F8Z6"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028132279.1"/>
        </source>
    </evidence>
    <sequence length="99" mass="11571" checksum="6CE068B7070A9744" modified="2020-12-02" version="1">MSLVYNISRFFKKKSVKYGLPFFVLMVGGSFGLREFTNLRYQFAKVSSVKPEDFEKLGVEMKKPGEVTLESEYEKIKKLNIDNWEQVRGPRPWEENAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FC71</accession>
    <name>A0A6P7FC71_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein lethal(2)essential for life-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114327901</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132417.1">
        <property type="nucleotide sequence ID" value="XM_028276616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FC71"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276616.2">
        <property type="protein sequence ID" value="XP_028132417.1"/>
        <property type="gene ID" value="LOC114327901"/>
    </dbReference>
    <dbReference type="GeneID" id="114327901"/>
    <dbReference type="KEGG" id="dvv:114327901"/>
    <dbReference type="InParanoid" id="A0A6P7FC71"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="7">
        <location>
            <begin position="54"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028132417.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20477" checksum="4DC6D8B18536673E" modified="2020-12-02" version="1">MSLLPYLFGDGPYNRPSRLFDQHFGMVLEPEDLFEPVSRNFLRCPAGYMRNWRSVASRNDDGSTVNFGKDQFSANLDVQQFKPEEITVKVTGDREVTIEGKHEEKEDEHGSVYRHFVRRYVLPKNYDMGKIESKLSSDGVLSIMAPKVEDESKEHKSIPVEQTGKPVKAVEGEKGAVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FD10</accession>
    <name>A0A6P7FD10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras suppressor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114329091</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133904.1">
        <property type="nucleotide sequence ID" value="XM_028278103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FD10"/>
    <dbReference type="FunCoup" id="A0A6P7FD10">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278103.2">
        <property type="protein sequence ID" value="XP_028133904.1"/>
        <property type="gene ID" value="LOC114329091"/>
    </dbReference>
    <dbReference type="GeneID" id="114329091"/>
    <dbReference type="KEGG" id="dvv:114329091"/>
    <dbReference type="CTD" id="34774"/>
    <dbReference type="InParanoid" id="A0A6P7FD10"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000159">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="6">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133904.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30908" checksum="430CA4E05B78ED5F" modified="2020-12-02" version="1">MAKPKKVLEEAREFQNPELDLFDRGISSFEELPGLLNMTNITRLTLSHNKIKSVPPGLANLTNLEILNLSNNHIEELPLSLSSMPKLRILNISINRLYTLPRGFGAFPVLEVLDLTYNNLKEDALPGNFFMMETLRALYLGDNDFEYIPSDIKNLKNLQILVLRENDIIELPKEIGELIRLRELHLQGNRLTILPPEIGNLDMSSNKSAFRFEGNEWVPPIAEQLQLGISHLQDYLRSETYRVLYSRMVTNKPPPPPPCVDKAKKISRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FE02</accession>
    <name>A0A6P7FE02_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114329117</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133936.1">
        <property type="nucleotide sequence ID" value="XM_028278135.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515525.1">
        <property type="nucleotide sequence ID" value="XM_050659568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FE02"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278135.2">
        <property type="protein sequence ID" value="XP_028133936.1"/>
        <property type="gene ID" value="LOC114329117"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659568.1">
        <property type="protein sequence ID" value="XP_050515525.1"/>
        <property type="gene ID" value="LOC114329117"/>
    </dbReference>
    <dbReference type="GeneID" id="114329117"/>
    <dbReference type="KEGG" id="dvv:114329117"/>
    <dbReference type="InParanoid" id="A0A6P7FE02"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027598740" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="21"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="79"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="309"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="645"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028133936.1"/>
        </source>
    </evidence>
    <sequence length="874" mass="98905" checksum="AA93BFBBBF34EDDF" modified="2020-12-02" version="1">MAEMIRYAILLVVLATTAAAIDKTVFKSCSERPFCNRLRNYVVDDKSKYSADVYSASIKDNILTVPLKNENGNSLNLLVSMFEGNKIRVKVEDPDSKRFELGDIVIIEELKELPLVSDTLDGTDGSLLVTPKDESLPYKVVIDAGPPLNITFYYGGLKQVVLDGERLVYESTDESKAFTFKADFPEANRLYGLLDHAWSLALGDTNNGTAESGDPLRLRNSDSWGYEANSPMALYGARPVVYGHSANKTSGIFLHNAAEQWIDASSGSEGKDPSVYFIVERAAFDLFILLGPTPKEIVRQFTGLTGKAHLPQIWALGYHQCRFSYKSQDDVKDVVARLDENDFPWDAIWLDGDHTDDYKWFHWNHTTYTDPVELQQNISATGRVCVSISDPHIKVDDDYDVYAGAKGKYFTKWANGSEYVADCWPGASSWIDYLNPEAADYYSTWFSFEKFNGSTPTLAGIWNDMNEPAVFDDSTEKTMPWEVQHYGGVEHGDIHNIYGLLHVKSTHKGLMARDQNAKRPFVLTRSNFAGSQRYAAMWTGDNSATWEHFANSISECMNANMLGMVFCGADIGGFIGDPSDELLQRWYQGAVWTPFFRGHSSRESKRREPYLFSKDVQDVIRNALRLRYQHIPAIYTLFYEHTVTGDPIISPLYYQYPRVNDRDTQTMIGADIMSVAVTKPGVKSVEVYFPGGYSDTDPFDKQTDFWYRADQKQFSQYRAGLVEQIEVDITSSPVFYRAGSIVFVLETPRKSAVEAKDDFYSIYVNVDRRNSAKGRLYKDDLYSFNYQKDNYFYSEAKWIPGSEKMYMTTISGTPDQSIRVFYVKVVVHELLESETGELQIKKSMFTKTSGGIPLHKIDIAKALREGNGTLELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH03</accession>
    <name>A0A6P7FH03_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 182-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327972</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028132500.1">
        <property type="nucleotide sequence ID" value="XM_028276699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH03"/>
    <dbReference type="FunCoup" id="A0A6P7FH03">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276699.2">
        <property type="protein sequence ID" value="XP_028132500.1"/>
        <property type="gene ID" value="LOC114327972"/>
    </dbReference>
    <dbReference type="GeneID" id="114327972"/>
    <dbReference type="KEGG" id="dvv:114327972"/>
    <dbReference type="InParanoid" id="A0A6P7FH03"/>
    <dbReference type="OrthoDB" id="6733873at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028132500.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="41431" checksum="F7ADB5E393970ADD" modified="2020-12-02" version="1">MAVEIQVNNHPILAIHRSICRICLNTTEPLNLWQDYENLKQLFEKITGIKIEGVKGVDRYICTKCVGQLQNIYQFIDKATYNDSLIKDTLHFCDITPFGNTQIEIHHDDRDRNDLHQSSQNNNLNGTESHIDLTEDSLEEIIQIKCENDDDINEVRSSEADDCFIEENFAINDTDSKLESADVKPYMYQFSKKTTDTNTDHTMTLRRKRTKSNKLRVPDYLRPFECPICSRRFTQKGNMHTHMRLHTGEMPFQCTFCSDRFRQLSNLNQHILTHTSNNKVCSICLRKFETDEELIQHRSTHALENKQYVCYVCSKRFSYQWSLSSHLQIHKKGTKNESNLEDTAGEDKEVVVLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHT4</accession>
    <name>A0A6P7FHT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC114330333</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19 20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028135456.1">
        <property type="nucleotide sequence ID" value="XM_028279655.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135457.1">
        <property type="nucleotide sequence ID" value="XM_028279656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501742.1">
        <property type="nucleotide sequence ID" value="XM_050645785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHT4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279655.2">
        <property type="protein sequence ID" value="XP_028135456.1"/>
        <property type="gene ID" value="LOC114330333"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279656.2">
        <property type="protein sequence ID" value="XP_028135457.1"/>
        <property type="gene ID" value="LOC114330333"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645785.1">
        <property type="protein sequence ID" value="XP_050501742.1"/>
        <property type="gene ID" value="LOC114330333"/>
    </dbReference>
    <dbReference type="GeneID" id="114330333"/>
    <dbReference type="KEGG" id="dvv:114330333"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028135456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028135457.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33747" checksum="297FC74D027CB20C" modified="2020-12-02" version="1">MAPIIEKVLDGFKLAEGPHWDTKKQCLYFVDIVEGTIFKYVPSTKKLTKAKIGNHNVSIIIPLKYRNNEFIVTLNNSIALIEWDGESTNINSVKQIYEVDAGTSNVFNDGKCDKTGRIWAGTMGASPTSIGELVKGKGTLYNFFNNKATPHRDGIGISNGIAFDYKRGKMYYTDSFSFRVDQYDIDFSQGKISNMKTIFSIKNQSELAEETFCDGMTLDSDGNIWLALFNSSKVYQIDPSKPETVLRFVELPAAQITSVAFGGPNLDELYVTSGNLSDRPGGQSPGSIFRVTGLNVKGLPADEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI74</accession>
    <name>A0A6P7FI74_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Fukutin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC114328192</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6 7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132776.1">
        <property type="nucleotide sequence ID" value="XM_028276975.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028132777.1">
        <property type="nucleotide sequence ID" value="XM_028276976.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028132778.1">
        <property type="nucleotide sequence ID" value="XM_028276977.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028132779.1">
        <property type="nucleotide sequence ID" value="XM_028276978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI74"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276975.2">
        <property type="protein sequence ID" value="XP_028132776.1"/>
        <property type="gene ID" value="LOC114328192"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276977.2">
        <property type="protein sequence ID" value="XP_028132778.1"/>
        <property type="gene ID" value="LOC114328192"/>
    </dbReference>
    <dbReference type="GeneID" id="114328192"/>
    <dbReference type="KEGG" id="dvv:114328192"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055105">
        <property type="entry name" value="FKRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052613">
        <property type="entry name" value="LicD_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627">
        <property type="entry name" value="FUKUTIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13627:SF31">
        <property type="entry name" value="RIBITOL 5-PHOSPHATE TRANSFERASE FKRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22921">
        <property type="entry name" value="FKRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FKRP stem" evidence="2">
        <location>
            <begin position="52"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="1">
        <location>
            <begin position="349"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028132776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028132777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028132778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028132779.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="58951" checksum="D0E82F692A4FCFE8" modified="2020-12-02" version="1">MRLRSFKTLPFLFVLLLIKILTFYYASRLFSGIIQSNIEDKIITPPIPKPPKKRLNELVTVILRDFESHENDVTLTLLSFTNAFVRMQIFVMYEELPYPPLDIVLTNNTLPYIKFIKLSPDLRSSFVDNYPISEIKSKYVLFVPDSTRVSSRQSLQLMINALSRNPGSIIAAVVKNHRQTLSCLNVNLNLREWNLQFDFIKSMTCDAVIGKHVFLLETKTLMMLSNAFLLPFPHSLYLQSSALNLKVHILKDVSFHEGKPLFRSHHAQWQQKQLEATRLKKLYNIFKIKKVIRETGITEWYGCTKETERCFGTVIDAMPSYLYERRWTPPCCLANLRKTAKHTFILLDETGIRYWLEAGSLLGAMRNGDILPWDHNVDVGFIREDLDRCSWLKMAKSKPVLDPQGFLWEKATEGNFYRVHYSKTNRIHVNLFPFYSKNGTMTKDSWYTNHKNMEFPEIFLHPMSSIEFLGRSVPSPNNIRDFLELKFGRGAIETPEYPDPSKLRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ27</accession>
    <name>A0A6P7FJ27_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General odorant-binding protein lush isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114330732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135946.1">
        <property type="nucleotide sequence ID" value="XM_028280145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJ27"/>
    <dbReference type="FunCoup" id="A0A6P7FJ27">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280145.2">
        <property type="protein sequence ID" value="XP_028135946.1"/>
        <property type="gene ID" value="LOC114330732"/>
    </dbReference>
    <dbReference type="GeneID" id="114330732"/>
    <dbReference type="KEGG" id="dvv:114330732"/>
    <dbReference type="InParanoid" id="A0A6P7FJ27"/>
    <dbReference type="OrthoDB" id="6610259at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF2">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028135946.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18583" checksum="11372C868BFD4E1C" modified="2020-12-02" version="1">MVKETSIEDIHSFVTRSLIKMCKMKCVWVILACSIIMTTGLNEKQMEAAKKVVTNVCTQKTKATLEEIDKMHHGDWEIDHSAMCYMWCAFNMYKLMHKNNTLNYASATTQLNQLPESFYESAKMSIEKCKDEAKTLNDKCVAAYEIAKCMYFANPDKYFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNN1</accession>
    <name>A0A6P7FNN1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114332367</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114332367</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137954.1">
        <property type="nucleotide sequence ID" value="XM_028282153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282153.1">
        <property type="protein sequence ID" value="XP_028137954.1"/>
        <property type="gene ID" value="LOC114332367"/>
    </dbReference>
    <dbReference type="GeneID" id="114332367"/>
    <dbReference type="KEGG" id="dvv:114332367"/>
    <dbReference type="InParanoid" id="A0A6P7FNN1"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027688204" evidence="2">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028137954.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="12798" checksum="23D10A778C920A9A" modified="2020-12-02" version="1">MGKLIFATFFILATLAIAEVEPRHVKTIDLHNNTTPTPEGVGIINTRPNDRNNKNKRDTHARPTPSEPSTSTQTHSTPLTPTEPSAPQLPWKGPESSKPRLESTNVTATPPFFGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FR37</accession>
    <name>A0A6P7FR37_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114330318</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135443.1">
        <property type="nucleotide sequence ID" value="XM_028279642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FR37"/>
    <dbReference type="FunCoup" id="A0A6P7FR37">
        <property type="interactions" value="1475"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279642.2">
        <property type="protein sequence ID" value="XP_028135443.1"/>
        <property type="gene ID" value="LOC114330318"/>
    </dbReference>
    <dbReference type="GeneID" id="114330318"/>
    <dbReference type="KEGG" id="dvv:114330318"/>
    <dbReference type="CTD" id="136035610"/>
    <dbReference type="InParanoid" id="A0A6P7FR37"/>
    <dbReference type="OrthoDB" id="10249565at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000073">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028135443.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17330" checksum="47D54048A76E5DD7" modified="2020-12-02" version="1">MAGVLFEDIFNVKDIDPEGKKFDRVSRLHCESESFKMDLILDINSWLYPMELGDKFRLVLATTLREDGYADAGDWNPQGLENEGSRADSFEYVMAGKVYRIEGDEAANEPSSRLAAYVSFGGLLMRLQGDANNLHSFEVDQHMYLLMKKIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRG1</accession>
    <name>A0A6P7FRG1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome subunit beta type-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114333282</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138944.1">
        <property type="nucleotide sequence ID" value="XM_028283143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRG1"/>
    <dbReference type="FunCoup" id="A0A6P7FRG1">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283143.2">
        <property type="protein sequence ID" value="XP_028138944.1"/>
        <property type="gene ID" value="LOC114333282"/>
    </dbReference>
    <dbReference type="GeneID" id="114333282"/>
    <dbReference type="KEGG" id="dvv:114333282"/>
    <dbReference type="CTD" id="39855"/>
    <dbReference type="InParanoid" id="A0A6P7FRG1"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000033">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028138944.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25837" checksum="3010DEED7D6FBD83" modified="2020-12-02" version="1">MMQTANNAYYPDYSTAPMQRQINPYADNGGSVVAIAGEDFVIIGADTRLSTGFSIYTREQNKLFPLSGTTVLGCAGCWCDTLTLTRILKSRMQMYQQEHNKTMSTTACAQMLSTMLYYKRFFPYYISNILVGLDNEGKGCVYSYDPIGHCEKATYRAGGSAGALLQPLLDNQIGQKNMLKTSGEPLSQEKALSTLKDVFISAAERDIYTGDSVLINIITKDGVKEESFQLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSL8</accession>
    <name>A0A6P7FSL8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114330593</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114347466</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330593</name>
        <name evidence="5" type="synonym">LOC114347466</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135790.1">
        <property type="nucleotide sequence ID" value="XM_028279989.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153968.1">
        <property type="nucleotide sequence ID" value="XM_028298167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654210.1">
        <property type="protein sequence ID" value="XP_050510167.1"/>
        <property type="gene ID" value="LOC126886977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028153968.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22297" checksum="2C49689DF21ED366" modified="2020-12-02" version="1">MRSTTSPINTIKNLLYGNFFGNKATRYGNENESKALLEFEKKFNLKVNESGFHIDQQYPFLGASPDGLIGDQALIEIKCPLSIKEHTPTDGIISKKISFAELINGELHLKRNHNYYFQIQGQLAITDRQFGYFLIWSPHGILVEKITRDDLFWKETMLPKLKIFYNNCLLPELLDPLHPKGIPIRDKVVTPSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW07</accession>
    <name>A0A6P7FW07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114331663</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028137088.1">
        <property type="nucleotide sequence ID" value="XM_028281287.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510382.1">
        <property type="nucleotide sequence ID" value="XM_050654425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW07"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281287.2">
        <property type="protein sequence ID" value="XP_028137088.1"/>
        <property type="gene ID" value="LOC114331663"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654425.1">
        <property type="protein sequence ID" value="XP_050510382.1"/>
        <property type="gene ID" value="LOC114331663"/>
    </dbReference>
    <dbReference type="GeneID" id="114331663"/>
    <dbReference type="KEGG" id="dvv:114331663"/>
    <dbReference type="InParanoid" id="A0A6P7FW07"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028518392" description="CLIP domain-containing serine protease" evidence="9">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="11">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="132"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028137088.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42555" checksum="D087E86F47F850AD" modified="2020-12-02" version="1">MVPTCLKSFCVFLVVVSLSNGQYGGDPCTTPAGIQGNCLPVRSCPSMMTALLTVQRPLSDTAREQLEAYYCSTDFKVCCPRVPIVIKELANRTDPDTSDPGQISSDVDMTKHRNYGLLPSDCGYLDVAVTKIINGQDAGRDYPWMTLLSFRGPDNRGAFDCAGSIINNRYILTAAHCLVDRSRLLGVRVGEYNITNKGVDCFGKGDEMDCNYPTQDLAIEDIISHPNYEQKQQINDIALLRVTPITFNDKNIKPVCLPRVKKSEFNPVSVEVSGWGLTKSFGRKSNILQMAFLKVVTPSKCQPFYQNLTVIDDSRICAGGLVTKNDSNACSGDSGGPLQVQERLPGVGLKYVQHGIVSFGVKQCNYPAVFTKVDFYIKWILDNMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FX51</accession>
    <name>A0A6P7FX51_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114335074</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114335074</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141031.1">
        <property type="nucleotide sequence ID" value="XM_028285230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FX51"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285230.2">
        <property type="protein sequence ID" value="XP_028141031.1"/>
        <property type="gene ID" value="LOC114335074"/>
    </dbReference>
    <dbReference type="GeneID" id="114335074"/>
    <dbReference type="KEGG" id="dvv:114335074"/>
    <dbReference type="InParanoid" id="A0A6P7FX51"/>
    <dbReference type="OrthoDB" id="6818455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028141031.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21547" checksum="2E64533EF357839D" modified="2020-12-02" version="1">MKIFDVTKPFASFKKSRHDAKMRLLSIVVVFFCVFVAFCSAIENKTDVTTPEDARAFVGRMLEQGRTLVHNNIKRFMILLPVIFFKLGIAFTMLVLVTMVSVNNGFIGFLLLVVGLSSVLARLQEARKPPVVPYVNPLPLYHAKYIQDWDRKDRGIGEKETTQVYGHTYGQQYIYPQVSGYYRQNGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXA6</accession>
    <name>A0A6P7FXA6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114333692 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114333692</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139437.1">
        <property type="nucleotide sequence ID" value="XM_028283636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXA6"/>
    <dbReference type="FunCoup" id="A0A6P7FXA6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656252.1">
        <property type="protein sequence ID" value="XP_050512209.1"/>
        <property type="gene ID" value="LOC126888199"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FXA6"/>
    <dbReference type="OrthoDB" id="6724830at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028139437.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="51272" checksum="CA14245E064386E1" modified="2020-12-02" version="1">MGERRGSGRLGYWIWDHFNNTLMFISFDQTQRLKSKSVATESTTGVNVVVDTTFKDTFGTASQTRFRKIYERRVRINDVNVVILQDCKDVALFSCDPKLLSLEFISFFHTKAVDRFLRSAIIYFQYYLQVWHRMQFRRVEASRKLRQPVVTELENVIRDDLADLRSMLARDYAVILTGVGDSKKFHHMYNKNNVSLSDKDRKRFEMFVKMAVRVIWIALKKKNLTIIEKELNRLLRTTIFSPTEHDQYKMYQFLPTSEEARILKGKACRSEKKLLHRSPLIQEIVFDQHDYRMLCIGVTDVEDHNERLDYLRMAYTAPEELLEDLEVGVGILGVQKKFLDPVLNEELITTRKRSSVMKPIPDFFMPPEKPYDYSKLSETLPKIKCKYRESPVATKARKTQCKLWRRYVKDKPGEMEQVPSSMLPYITSSRIYETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXX3</accession>
    <name>A0A6P7FXX3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114331927</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137420.1">
        <property type="nucleotide sequence ID" value="XM_028281619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXX3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281619.2">
        <property type="protein sequence ID" value="XP_028137420.1"/>
        <property type="gene ID" value="LOC114331927"/>
    </dbReference>
    <dbReference type="GeneID" id="114331927"/>
    <dbReference type="KEGG" id="dvv:114331927"/>
    <dbReference type="InParanoid" id="A0A6P7FXX3"/>
    <dbReference type="OrthoDB" id="6683749at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF27">
        <property type="entry name" value="ELASTASE 2 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028160476" evidence="2">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028137420.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28958" checksum="D16B8C0581CF22CF" modified="2020-12-02" version="1">MYRKAFCFCLALFGVVSGIYDNGIIASQGQYPFIVSIQTKALGEELHVCTGAIINERWVVTSAQCLYNYPETIVAGLIYIDDETDSNKQIVNIEKTIKYPKFDSDGNGHNDIALIKVTEAFQFNDVVQPVKLPETGAQGSGNADIVGYSYNLFHNYHHLVYRPALPIIGIDRCNELIKIFEDSMYHQLYADKDSNICVLDYAYGNNCNGDLGEPLYQNGTLLGLASFWVMPCFEHGAPDVFTNVAYFVEWINQVSDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2W4</accession>
    <name>A0A6P7G2W4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114333290</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138950.1">
        <property type="nucleotide sequence ID" value="XM_028283149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2W4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283149.2">
        <property type="protein sequence ID" value="XP_028138950.1"/>
        <property type="gene ID" value="LOC114333290"/>
    </dbReference>
    <dbReference type="GeneID" id="114333290"/>
    <dbReference type="KEGG" id="dvv:114333290"/>
    <dbReference type="CTD" id="36670"/>
    <dbReference type="InParanoid" id="A0A6P7G2W4"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028138950.1"/>
        </source>
    </evidence>
    <sequence length="718" mass="80640" checksum="E1A7A513097FBDD1" modified="2020-12-02" version="1">MGWMTCCQCKSNEAKVIELDFSRCGISEIPNEVYANSPTLEVLHLEGNKLKDLSPQLFQCIDLRYLNVSDNEIRAIPPLISKLTNLQVLIFSKNVLDGVHPNLDKLSKLTMLDLSMNDLGKVPEAVMSLINLQQLCLNDTGIDFVPANIGRLSNLRVLELRDNNISELPKSIRRLTNLQRLDVSDNNLSNLTELCESHGNLTELWINGNNISELSVAITHLKKINDFDASYNNLESIPKEIGHWTKITNLILSFNNLISLPKAVGNLRNLQVLKLESNLLEELPSTVCKLVNLEELNLQNNSLISIPSGIGHLRKLATLILSDNKLQQLPAEIGSCCELSILNVHNNQLERLPDEVGHLQNLTTLGLIGNKLSYLPITISKLRNLKALWLTPNQTQPLIHLQNEQLSDGQVVLTSIVFPQTPLREPHPVQMSVGNQNCHITFSTERNDSDVTEAHLSLSRTPTPHHKELKRLREILRTSHIPGKKPLNISEIKEAKVTNISGELAVSQNSLNDHDVTDIPENVSDIIREISKTPPKQPPPYHIAAVYSKNAHLFSQNQNMSPPSPLDQPKQFSQQQPSNIHMPTPKLPNHRNHIPVLQIADTSNDLKDVNMMCEEDLNQSKQMVKWPFGKHKVCQVLEVEMPESFLPKDIRIVGQSNGLFIDHVNPQSQVFQKICVGDKILAIDEIDYTIIEPVIAYQDACQRLNNLKIITVSRNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3K5</accession>
    <name>A0A6P7G3K5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger CCHC domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114333800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139603.1">
        <property type="nucleotide sequence ID" value="XM_028283802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283802.2">
        <property type="protein sequence ID" value="XP_028139603.1"/>
        <property type="gene ID" value="LOC114333800"/>
    </dbReference>
    <dbReference type="GeneID" id="114333800"/>
    <dbReference type="KEGG" id="dvv:114333800"/>
    <dbReference type="InParanoid" id="A0A6P7G3K5"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028139603.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14040" checksum="197FDCD071512123" modified="2020-12-02" version="1">MTLGNHSKAYFGQKKTPTYPPQGVRCQKCLEYGHWSYECKGKRKYVHRSSRTQVLKKKLKTKEETTVNSNEANTNREQSSKENKSSRNNSSSEDSSSDSESSDSSSSDSNSSSSSSSGSSSGSESDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9H5</accession>
    <name>A0A6P7G9H5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable RNA-binding protein EIF1AD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 1A domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337302</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143512.1">
        <property type="nucleotide sequence ID" value="XM_028287711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9H5"/>
    <dbReference type="FunCoup" id="A0A6P7G9H5">
        <property type="interactions" value="1885"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287711.2">
        <property type="protein sequence ID" value="XP_028143512.1"/>
        <property type="gene ID" value="LOC114337302"/>
    </dbReference>
    <dbReference type="GeneID" id="114337302"/>
    <dbReference type="KEGG" id="dvv:114337302"/>
    <dbReference type="InParanoid" id="A0A6P7G9H5"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05792">
        <property type="entry name" value="S1_eIF1AD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028143512.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17617" checksum="214FCF35B8596C25" modified="2020-12-02" version="1">MSRATKRKHVLLEVLQDDYSPPTENQQIVRVLNSRGNNLHEVEAPDKSVFLVSMPTKFRKNVWVKRGDYVLTEPIEEGDKVKAEMVRILTPEHIKYFKKDNVWPKEFDDKKEDNDDEDDLFVNRNRPVFDEDESSSGSDSDEESSESENND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9J3</accession>
    <name>A0A6P7G9J3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335176</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141160.1">
        <property type="nucleotide sequence ID" value="XM_028285359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9J3"/>
    <dbReference type="FunCoup" id="A0A6P7G9J3">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285359.2">
        <property type="protein sequence ID" value="XP_028141160.1"/>
        <property type="gene ID" value="LOC114335176"/>
    </dbReference>
    <dbReference type="GeneID" id="114335176"/>
    <dbReference type="KEGG" id="dvv:114335176"/>
    <dbReference type="InParanoid" id="A0A6P7G9J3"/>
    <dbReference type="OrthoDB" id="7408914at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141160.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34127" checksum="71BE59BE66914DF1" modified="2020-12-02" version="1">MEWTREKCLDLIELYERYPVLWNPKHEQHYNKIKKNDAWILIAEKVGCTSEEARKKMDILLASFRREKIKLIKSRGTAKGTDEIYVSKWFGFSRMVFLLDRDEPKTARDSVEEVYIESVNENNEEVKETLTNFTINEAELQIPSPETSKSKRKATVAVTSATPMRKRKRQSISEDTDRRSSDDAKVDEALGILKIVAYNVTSDACGVYGQHVAFKLRSYTRTTRNIVEHHINNILFKADMGHYSYTVTPPVHHQSIPQSPSAYSSQATSNQTPLPTPSPQHQTASAHSVKFEDFDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9M9</accession>
    <name>A0A6P7G9M9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114335197</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141195.1">
        <property type="nucleotide sequence ID" value="XM_028285394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9M9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285394.2">
        <property type="protein sequence ID" value="XP_028141195.1"/>
        <property type="gene ID" value="LOC114335197"/>
    </dbReference>
    <dbReference type="GeneID" id="114335197"/>
    <dbReference type="KEGG" id="dvv:114335197"/>
    <dbReference type="InParanoid" id="A0A6P7G9M9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028141195.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22227" checksum="48CE3BA194587071" modified="2020-12-02" version="1">MEEVEDEETKSLLTDEQINEFQDAFDLFDRDDDATITVKEFCTIMRVFGQTQYEIELEEMFRAADVGEKGTINFGEFLGIMKQHYVEDKTSEGINEAFRAFDPLRKGIIPADDLREYMMAYGDHLTEEEASAFIKAADSNKDGQIMYEYFVSKMASKLEKPDKYQPKFAKSKSKTNNNINKKNNSSKNIQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCD6</accession>
    <name>A0A6P7GCD6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sperm flagellar protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114336363</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142518.1">
        <property type="nucleotide sequence ID" value="XM_028286717.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286717.2">
        <property type="protein sequence ID" value="XP_028142518.1"/>
        <property type="gene ID" value="LOC114336363"/>
    </dbReference>
    <dbReference type="GeneID" id="114336363"/>
    <dbReference type="KEGG" id="dvv:114336363"/>
    <dbReference type="InParanoid" id="A0A6P7GCD6"/>
    <dbReference type="OrthoDB" id="62528at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056199">
        <property type="entry name" value="SPEF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054517">
        <property type="entry name" value="SPEF2_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052634">
        <property type="entry name" value="Sperm_flagellar-bone_growth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919">
        <property type="entry name" value="KPL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14919:SF0">
        <property type="entry name" value="SPERM FLAGELLAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24082">
        <property type="entry name" value="SPEF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22946">
        <property type="entry name" value="SPEF2_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPC1/SPEF2" evidence="2">
        <location>
            <begin position="304"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="SPEF2 C-terminal" evidence="3">
        <location>
            <begin position="1349"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1642"/>
            <end position="1662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028142518.1"/>
        </source>
    </evidence>
    <sequence length="1829" mass="213176" checksum="84AAD44332E990FA" modified="2020-12-02" version="1">MAEVVSQWIQEKLGVLVSLNPEVFCDVTRDGYLLSKILRSYEIINEDQLSLIQRAEIKDICLSNFQNYLVHWLKPINIHLEDEDIANITEGKKLASLSIFYRAFLELHEKDCLTFIAKSKLNGELRNSVSKFTVSKVKENPFSKLENVENRYNVQLENSYDVVHWLQDRFEMVINKCKTAREEYLATIRNSERRVSSSFAIPGIAVHHQAPVFDFYVDNASPKSVDLTYDELVEETRKIRTSAFIPDIKQAKEITQKIKDKFKDKADADIFRKDMEEYIRKVFWNRLLNEENQDFETHLSSKMLKQSLYETQMLKKMEEIAKQEEHMLRSKQIIVDEIMKEQEALFVEKLLEKDDSIDKKKFEYYLEKERLNQLHKVLYGEVRRLREEKKQKICRDTVKALCDMTIKYSEFQSYFEEPPQRRVLDQWNKLIVSGLSLEDPAVSAVALIDEKSIAPEQIKLKELERQSKADEKEFESYVNFEWPWLLSQINVEEETLYKLNCGMNVLGQKVHLLLDEKYPLPALPTPPDLPRAHIRVCVNGLSDITCLPLLSKLLQHKNIVVVELQDAVTYCMSAYKHEIAVTKEEETKDDALEEKVTKVKKEKVVKGKKGKAAKRPKKEGLQTSVDHQDKLVQTPRIFPSEEIVLTPFAELGRIAEEELSKGNVLTDYLLVSMFIEYLRSKPDIEGWVLINYPTNIEQAILLEETLSGLKVPGVPESSRICKSLIDIVYICDPEDDVEEDERRFSKLVRDPTQPLEPPAYDTVLTGFINICPDIDQETTAEWTESSKEQMSSFLNEPEEDLNLKQFYADMGCYYSLYYKSFEYSPVKQLAKLIIGDYTIPPKSSIELFGDVIRYIESDKVAYNRPFKSVKSGEKVERERIEKVFKKTEVSLASSEIVTLEKPKKGKKEKKAKKQKGGTIIVREEKYTQIPSVTIVEIEEDDPTAYQIEPKPGEPGYKYLTVPIHDKIGSVITNFWEHMEEVFVNDMTQVLFLKKTHLNMLMPYICYVKTLINKHIIKPDERQMYLMQFQERFNQFDSDFRRDNEFKAELHCLVNELKNRLLDMCDNKMIAAEQERRAIIHKNWSPIQLAEIINNYINGFQLELDRHIDTLMFINDYFTGLISQVITEDEITKEILHKFELENKTFEKLVNDYLLDKEEHEHNENPLKGRLEAIYHTALVAAEVREVTAFDHFMKVKLLCHPDEGKGKGKAKKKKEPKTLLTAFEQSKSVKNNQDRIFDEWLCALHGEIARVEVRFLLLKHDMFENVIWFIKALRKTFNEMHSNIKTRYIKEVECVKKACHFLSTAIENEVPIQEELLFVDDDFLINADSLMFESPVQQDVEELSDDLLFSVSKLQKITDILSDLAPDGFLQCAKFIFILQDFIASEKPYLVPKEWRKLEGYRVKYLSQRLFESQSYITWKDFIIYNLTIPIPTDKELVSLKNQCLLIDTLRSEVISKEEFLRLHFWFDKDDENKDKSNGDSVKKLLFEMYRYDKESCNYTAMLLDFCKGASTQEGVAKALAVVIGKPVCWSEDIGRSFVEEVFRKREIHEEEVRQREIELQEYREFIGSIINSIIDKTVHSCDSVVITEILPRDDEETREVGFDIDNQGEYIPHERRETASRHSRHKNDVKGFRNSAKKMSRASESHEYRQRSKSRNSESHEHRPRSKSGTSESHESRQRSKSGTSESHENRHRIRSVPETETTGKSYIKGESVTTTSSHPHKQKSSSPPTSSNTIGFENQTSPSLCYFLRYDDIAKVLAATLSNILGSKDNKFFDVLCNIYQICKNSAFNNEVLCHEFLNCKDFLQLMEGKTKFVIKYPGRIVKEMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEP7</accession>
    <name>A0A6P7GEP7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sperm-associated antigen 7 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114336401</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142560.1">
        <property type="nucleotide sequence ID" value="XM_028286759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEP7"/>
    <dbReference type="FunCoup" id="A0A6P7GEP7">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286759.2">
        <property type="protein sequence ID" value="XP_028142560.1"/>
        <property type="gene ID" value="LOC114336401"/>
    </dbReference>
    <dbReference type="GeneID" id="114336401"/>
    <dbReference type="KEGG" id="dvv:114336401"/>
    <dbReference type="InParanoid" id="A0A6P7GEP7"/>
    <dbReference type="OrthoDB" id="5979509at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017330">
        <property type="entry name" value="SPAG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498">
        <property type="entry name" value="SPERM ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13498:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037943">
        <property type="entry name" value="Sperm-assoc_antigen_PAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028142560.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27123" checksum="1152A4DF054D0658" modified="2020-12-02" version="1">MDLLGSIMNSMDKPPSLTEKEKQLKKKRKEEIERRQNEEKDKLKRFKDRVEAKLLSHFKDTSNLTLKFEPMDQICRSIVHELAEACGLLSFAFGIDGVDRYIRVYKKEYPPCEDELAARRRGEPWNEEVKRRLIEKRRLDNLDDQEQECSSKKSKKFIPNSNYKDKYVHLIGEDAALKAAMKTQTNKSYGYVPSENKKDVRSIEQTMADIMAKKKQKLHTDPSESSSSALSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEQ3</accession>
    <name>A0A6P7GEQ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endocuticle structural glycoprotein SgAbd-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114336407</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142565.1">
        <property type="nucleotide sequence ID" value="XM_028286764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEQ3"/>
    <dbReference type="FunCoup" id="A0A6P7GEQ3">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286764.1">
        <property type="protein sequence ID" value="XP_028142565.1"/>
        <property type="gene ID" value="LOC114336407"/>
    </dbReference>
    <dbReference type="GeneID" id="114336407"/>
    <dbReference type="KEGG" id="dvv:114336407"/>
    <dbReference type="InParanoid" id="A0A6P7GEQ3"/>
    <dbReference type="OrthoDB" id="7781803at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF109">
        <property type="entry name" value="CUTICULAR PROTEIN 49AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027960898" evidence="4">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028142565.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24649" checksum="471D117DA2A12FFD" modified="2020-12-02" version="1">MKFLIVAALVFGACSAEPQRRPHSYYDNQAEQDTNVPQNYQDNSDQYQQNSVQQNPPQHQEKSQYEPRVKETIKFIPIIRFDKEQGEAGNYKAAYETGNNIIAEEEGYLKELGPDPDQQGQVIKSQVQQGHFTYTSPEGVVIETKYTADENGFHVEGDHLPTPPPVSAEVQKGLDLIFAGIRAQQEALEQRLKDHPEERDRPENYDDGQYRPAQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF12</accession>
    <name>A0A6P7GF12_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114337369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114337369</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143583.1">
        <property type="nucleotide sequence ID" value="XM_028287782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF12"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287782.2">
        <property type="protein sequence ID" value="XP_028143583.1"/>
        <property type="gene ID" value="LOC114337369"/>
    </dbReference>
    <dbReference type="GeneID" id="114337369"/>
    <dbReference type="KEGG" id="dvv:114337369"/>
    <dbReference type="InParanoid" id="A0A6P7GF12"/>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056587">
        <property type="entry name" value="EF_EFCAB10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24548">
        <property type="entry name" value="EF_EFCAB10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028143583.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49742" checksum="13B81EEA58ED5F92" modified="2020-12-02" version="1">MSFSSVSKSSSGGSEHSKKSKQSKSSKNGITAKPSQTLLPAFSTSSARLRHEQTLRNKSELESDIPPDKEDKEELIESIILEPKEEKLSTFGELYAHLPKLGLADYQKRNMGKEDLFPKVLTLDSANELVEVKKEAPSILVTGFGMRNLQSLQNALDEESKRLLEIYRRQQKHKAEITCTRTPDVSLASASSSTSTSTTKSTSTSETVTEAETIGERLKLEYLMGLHQDEEEEYLEMEPEPKEDKELSFIYSSSIAMKKAQHYLRVHRIFDFIRFIIAHLLGSAPENPVSFILELLNKCLLYRSGAGQPPLLYEMKHISQMFLLMDRMNSGFIEMNQYVQGMTTFGLCDYNKKPSMTVEGISKKTFVEEVYEAEINFFNDIIRRKYVKGKGHKDTERAINYDNIPSRESRTAYFIPSDLFKSIKREKLSQIKEDTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIJ3</accession>
    <name>A0A6P7GIJ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein lin-54 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114338617</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145018.1">
        <property type="nucleotide sequence ID" value="XM_028289217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIJ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289217.2">
        <property type="protein sequence ID" value="XP_028145018.1"/>
        <property type="gene ID" value="LOC114338617"/>
    </dbReference>
    <dbReference type="GeneID" id="114338617"/>
    <dbReference type="KEGG" id="dvv:114338617"/>
    <dbReference type="InParanoid" id="A0A6P7GIJ3"/>
    <dbReference type="OrthoDB" id="6283463at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005172">
        <property type="entry name" value="CRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028307">
        <property type="entry name" value="Lin-54_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446:SF34">
        <property type="entry name" value="PROTEIN LIN-54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12446">
        <property type="entry name" value="TESMIN/TSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03638">
        <property type="entry name" value="TCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51634">
        <property type="entry name" value="CRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRC" evidence="5">
        <location>
            <begin position="518"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028145018.1"/>
        </source>
    </evidence>
    <sequence length="738" mass="80534" checksum="6D5F3273B6D6D816" modified="2020-12-02" version="1">MSFSEKGNGEDSESMEAMNIENSQLENSLSSLSSNDMHHLNEFSQELILNPDMETEEMVVENQEEIEHEEEVETEEVATEDLEVIIDQSNKVDEHFSDLKISKLNMAVPPLRPLTIAPKPTKVPLTTVKAVGGQLGGQPLLFLQGVQGAGSGQTIKLVASQGQEIFTNIISRPLTIKPSFKTISTQGSNISLVQQKPVLMKKVVAANSKTVTKTVNSISKPTQHFMVVQKSDQQQLKLIQAQGNVLGVPAPTKTITLQQAQEMGLITSTKIAQPGHSTGKQSVLLAKNPQKSIKLIPQSNAPQILTTTELQNIPTKTVTLNQVKAPTKILPAVSNSINKGTQRLIFKTAAGSPTILPQGQILQVSAAQAMNSGQVHQINIPGKGMQYIKFVTSTADANTTTAGNVVKSSPIMTPTNIVLSEVKPISTLNRIVPKIHPKDKVPISPNSKTLTSTPLMVMPVQIPTTQSIQFQSKFTKVSIAPPASPQQKPAGSTKSSTGSNENTSPQSKEELDANGMRPRKPCNCNKSQCLKLYCDCFANGEFCYMCNCMNCFNNLENEDHRNRAIKACLERNPNAFRPKIGKAKDVVGDTAIRKHTKGCNCKRSGCLKNYCECYEAKIACSNNCKCFGCRNIEETIDKKSVRHLSEKATNTPACPAPLDSNGKNLGPFRQRRSSSSRKQTINFITDDVIEATCQCLLTISDNADESIQDEEVTKRLIIEEFGRCLTEIIDCSSNRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GK12</accession>
    <name>A0A6P7GK12_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fanconi anemia group D2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114343617</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150256.1">
        <property type="nucleotide sequence ID" value="XM_028294455.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7GK12">
        <property type="interactions" value="1685"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654269.1">
        <property type="protein sequence ID" value="XP_050510226.1"/>
        <property type="gene ID" value="LOC126886997"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GK12"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1327"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1341"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028150256.1"/>
        </source>
    </evidence>
    <sequence length="1370" mass="155387" checksum="EB6F89A116C0079C" modified="2020-12-02" version="1">MYFKSESLLISLKMSLTQSSQFLTSQNSIQKSQDIKTRIRMFKTTLEEIGIQLSFGDEPHVLTQEQSLVVRDLEKYLEQSKDVFESFMTGLKILCKKEKYFKKALALTYLRKRNNETIGASAGQRKKDEQESLFRIFLKVGCLQTEVTEVLLEEITSISCEATEDTSWLHSLLSSFRYLPYMKDPENITTKLIDILEVATYPAQLEILDTIPEIIPDSQFSETTKQLCKLLDEKDELTGAIIDCLNALDLDADMRTEVQDRVLERMSGGTSLKDFPILLSFLMSDCKSQNSVPVLLKIRNALDSIMLTPEKSKDKESSKILIFNKLQSFTISSKAASEAWLNMISSIKSSSDHKPIDYLIMFMLYNVAPFKKRIIEAIFRKRVHSGLFKINNLEKMFDKYLPQQLLKDYLTSIVEIGSHLARSSGDQIIKEFCLTLYKLLFNHEYTESIYRREILNNLIVLIGASDKKTVNTVLSIISTLADNKEKLQQHIMILMRLLEKLDSLDPTDVKVMFEILCGLTCGPDVDSSMSGAQNEIHIIIRKQLCGTKKSIKYRGIIAAVVMARSIARISSEDTRELPKTSMKSLSSLPRGPAREAGSLLELANTCSSGYPDLIGLYYDQLASMLISKYQLDKFFLAWLYETVTEEFRKIYISESLPQPINDLEMTFQYTLNRSTEVDSPMGINIGELTLKKNPAILVLAPRFRLLRLLHYRQQDGNLSTIDALLGSAVILPRFDDVDYFDSDQIKQVADCLFHSANWFRELISGFVTQKDKKLRMRVIQRLGNLLEVESNLSKCLAQSPNHKFPASYFDLHQEANKNVIVKSDTRAKNPKKKVKTSATVEADDTVNSTIATQSNKRKASTSNVSSSVEHKIHFRDLDTDAVLLLKYPLSLSDESSPTPSQAATLQLEELKFLLKDLVLKLTITTQSKNAGLSHLNEVIPLHIITDVGYVLPNLDLHLRVIVDKLNKLLEETDGRTDLAEMFSPTAINYKTCFGLILESLLLIFSWTGFQHYSNLEVLKNMLKSMRSTEQSQSLHSAHRLIIELINRLSGYHEQCLELSHAVYLLKTMEALYAITTPSPDIQKKISAVAEKLLSRRWYNSKGIPESGRNCYLNIDVLVKTYLSSADVETLTGLIGTLQEQIESLVSKEDYLQMLNSIDKPNFHVLYNGLCSALVNRTKTEIEHLSNNQHIILWTNVTLALLGLKNIAQKQETRTNLGCYLKKSIAVLKIFLSHGIPMMELMLKSKPDEVVTIFKTMQSSTRFLHHLCCYSKFTKDASLMAYVPQFRLTLESLVYRVKAALAANNCSSAFWMGHLKNKDLHGEEILSQSTVMTDDNDKGSDEELLPSDESDTEILNVNNEDDRSVSSEVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GM51</accession>
    <name>A0A6P7GM51_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114344073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114344073</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150729.1">
        <property type="nucleotide sequence ID" value="XM_028294928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GM51"/>
    <dbReference type="EnsemblMetazoa" id="XM_050659474.1">
        <property type="protein sequence ID" value="XP_050515431.1"/>
        <property type="gene ID" value="LOC126890491"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GM51"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027639870" evidence="1">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028150729.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22613" checksum="FD2F3C4E731F868A" modified="2020-12-02" version="1">MCSSVFILGSLFVFGSLINGSKGNVEWKNYSKIEVYGNAIQIDVLPLNESIYVGQVHVSDNISDAHLPANIIIGENYTRVTLNKKLLFVFEDIKILVSNNKDKFGWKFTNKDNLYKNFDQKEYVPLQVGWEYNSVEKFNASIYLGKALIPALGGHFIGKVYKGHPDENRNGGLWIDFPDEEYPYWLNKGNFELAVLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSA7</accession>
    <name>A0A6P7GSA7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 134-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114342345</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148947.1">
        <property type="nucleotide sequence ID" value="XM_028293146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSA7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655916.1">
        <property type="protein sequence ID" value="XP_050511873.1"/>
        <property type="gene ID" value="LOC126887960"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GSA7"/>
    <dbReference type="OrthoDB" id="5854099at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026321">
        <property type="entry name" value="CC134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15002">
        <property type="entry name" value="ERK-JNK_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027873707" evidence="2">
        <location>
            <begin position="28"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148947.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="26228" checksum="3FA25182DF46C3F2" modified="2020-12-02" version="1">MLFEVMWNSRTFFFLHIILIFLPLIYPETQNQESEAAEELYKKLFKQQRVEQLNAIKSFEKTSNYEKQYAMITLMAEKIFDTIAESRVFVESSFVPGISEFPLDSERKAAISSILENTVLFSEIALRFPEISTSLLKRNKNWDLVLQWGIAFTYHMRHLLDDNTIQLLRLVSQELNHVERHPDYVNPYRKSPEVQKDIVQPKPKKKKKIIKKGPKLSSRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTX5</accession>
    <name>A0A6P7GTX5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger CCCH domain-containing protein 13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114342228</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148818.1">
        <property type="nucleotide sequence ID" value="XM_028293017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTX5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293017.2">
        <property type="protein sequence ID" value="XP_028148818.1"/>
        <property type="gene ID" value="LOC114342228"/>
    </dbReference>
    <dbReference type="GeneID" id="114342228"/>
    <dbReference type="KEGG" id="dvv:114342228"/>
    <dbReference type="InParanoid" id="A0A6P7GTX5"/>
    <dbReference type="OrthoDB" id="6022762at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040427">
        <property type="entry name" value="Flacc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38563">
        <property type="entry name" value="FL(2)D-ASSOCIATED COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38563:SF1">
        <property type="entry name" value="FL(2)D-ASSOCIATED COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="67"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="95"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
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            <begin position="171"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
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        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148818.1"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028148818.1"/>
        </source>
    </evidence>
    <sequence length="1129" mass="131107" checksum="8EF64134BD7E1E8B" modified="2020-12-02" version="1">MSKIKRKITVNLSTKGKSGVLKTRPSVFERLGTKATNTGKEYCHPWAQSGSCPYGKGCKYSSTHTLISPSKQRAAKTQRRHVKDGHKRSQHEEWDQWDPDELEDADPDDLERKRQELQRELELQMKMESKAKKKEKKKESSPSTDTSSTTTDSSTSSDDSSSTSSSSAEARRRKLKKIKTKRSSSTSSEERGRSKHKSKIKRTSKSTIRDKSKKGSKMIKTKSVSPTRQRKKSETPPIKSKAISSFKKLSSEKSPRPLSRTSIKEKHRTPSPKPSKDKEREKEREREREREKEKDKEREREREKEKEREREREKERERAKERAKEREREKEKEHKKKEIARSPKRDNRSIKDIRKRDTPDSAHPKDRKLSPGRSKGGGRRDHKSPMKDERRTDRRDDRGRGKDIRSTDRGPARKETTKRDSRDRERERERDRERRLAREREEAREKEREEALARCQERQRERERLKKEEEQRRRERTRRDDRGLDKPSGDRVERLLPPIEERVPPSRKGHSTERDRDRGRDVRGRDRSTDRPRKSPDRRGDMDKDRSYDRGYDNRSRPDPERDYIPGHRDKDYDSPYERGRPLDDRRYLDVDEHYGEGVRDDRMYGAPVDDRRSRRDMWDERGVDDRENIDHRSRYAPRDDHNLKNNRGGDWGDLQHGEYSNHDWDRNRRPVNSEWDARENWDIDQHKQTGAGQGEDDWRHYNRPVDSWTNDDRRRWPQEWRDRSRPRSATSHQVEPVNVPPSEDSNLESNRKKEIPPLLQPAPAAEEPGVKPESSEEETMKQSSPPPVKRAADEAVDSPGSAKKICVKQETVQPPLEDDLSEISDDADDILNMVEDVPDSPIKEESTEAPEIQEAAATTSVAALEVNTSATSQKSQSPPPEQQTAPKSPAGVAAPNNKGGSIDEDNMELDFEEISEDELEEESKMRGLVDALGVDWSSLVAESKPRTKPFSCAKIRWEAHNVLVNLGVSVQLAGETLVKDILKQHAAAKLEHQKEEVVVKTEISSIVIKKEPQELIMNGVEVKIKSEPTEETQMEQICEIKMEPMDTEEIQVPHPIAVIQVADREKLAIRKSLFTSVGSHRRALAARRDLTIRRHLCNLPITDKHVEAPKRHNPELFQLATQLFERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GU43</accession>
    <name>A0A6P7GU43_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rab11 family-interacting protein 2-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Rab11 family-interacting protein 2-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114346738</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153290.1">
        <property type="nucleotide sequence ID" value="XM_028297489.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153291.1">
        <property type="nucleotide sequence ID" value="XM_028297490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GU43"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663188.1">
        <property type="protein sequence ID" value="XP_050519145.1"/>
        <property type="gene ID" value="LOC126893219"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8956628at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000151">
        <property type="entry name" value="Rab11 family-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF23">
        <property type="entry name" value="RAB11 INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="9">
        <location>
            <begin position="412"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
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            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028153290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028153291.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54682" checksum="D889E2432017CBE7" modified="2020-12-02" version="1">MWVPTHVQVTVLRAEKLLVKGKNNTNDCFVTIALGKTKFQTSIKEKSGQLVEWHEECELPIPDQGNTAEIVLTVLHHNYLGIDEFLGRVNIPLNTLDVYERPKNKWFTLQSKPGKPAKSKERGNLEVKIRFSVKSGSLTNLSKKEKHKSSVSNVAHSLGGSLMSLGSAEKRKGIKKFAKSIGSKINLRGKKKDHDDDGSSIGSIGSLNIRSAQENFKSKQSIEDADPGVVSDDDDFTLDDLSHKSSASSLNHPVVNRTASPILKNPSVENIVHVEKKSTVAPVKPPRIDQKEPQDEWESKLVGNKPRGVLRPGSSESLNRRSWDSSKLASQIEEEPAELLDVPKKNFETISLRSTKSPETPRKEAKEGMFSKFKNFRKDKNDFLNDNDKPTGNSSQRIIIGGETEVKVTSQNNRISNELQQKFEGKSREDLILSLVETQNALEKQKKKLKDLEDYLDDLLLRVMETSPRILQNPYVTCKMAEYSKMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GUN0</accession>
    <name>A0A6P7GUN0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine hydrolase-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114342495</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149108.1">
        <property type="nucleotide sequence ID" value="XM_028293307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GUN0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646444.1">
        <property type="protein sequence ID" value="XP_050502401.1"/>
        <property type="gene ID" value="LOC126878432"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GUN0"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028149108.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36370" checksum="B48B007E3550E2BD" modified="2020-12-02" version="1">MDLLPLNDMVENNEESRNINELTIPVAWGHIAVKAWGEPHHKHVLMFHGIGDNAGSFDNLLALLPKNFYYICTDFPSHGKSSHLPLTIPINANGYILIVKMIMDYFNKDKYIFIGHSLGGLCGFWICKIYPERFEKFIAIDGSHFFTVEAKDCIKYLKLMLSKQEKMRQYLLQGKGLEYTYDEIAEIVSTRRYGDEVLTRKATEPLLKRCLEPTGNGRYYFTTDLRVFFMIGPLQDISYARDLLRMTSFSCPVLMVLAKQNQRLLRDFKPTVKEVMKTENITTVFVDGKHDVHNNRPELVARHIIHFLQNKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GY17</accession>
    <name>A0A6P7GY17_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114344361</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151002.1">
        <property type="nucleotide sequence ID" value="XM_028295201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GY17"/>
    <dbReference type="FunCoup" id="A0A6P7GY17">
        <property type="interactions" value="1507"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295201.2">
        <property type="protein sequence ID" value="XP_028151002.1"/>
        <property type="gene ID" value="LOC114344361"/>
    </dbReference>
    <dbReference type="GeneID" id="114344361"/>
    <dbReference type="KEGG" id="dvv:114344361"/>
    <dbReference type="InParanoid" id="A0A6P7GY17"/>
    <dbReference type="OrthoDB" id="1910009at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051084">
        <property type="term" value="P:'de novo' post-translational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.50:FF:000001">
        <property type="entry name" value="15 kDa selenoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF6">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028304622" description="Selenoprotein F" evidence="7">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="8">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028151002.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18509" checksum="286DA0D6EC68A50B" modified="2020-12-02" version="1">MRLVAIGLFVVLPSLVLSEFSTEDCWALGFHKANLLCSSCDQLVKFQLDELVNHCKECCHPDEVNSSEKVYYKAVLEVCTCKFGAYPQIQAFIKSDRPDKFPNLQIKYLRGLDPIIKLYDKDGHLQETVAIEKWNTDSVEEFLSTHLIKLDDDDYLRTNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZU8</accession>
    <name>A0A6P7GZU8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114348530</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028154884.1">
        <property type="nucleotide sequence ID" value="XM_028299083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZU8"/>
    <dbReference type="FunCoup" id="A0A6P7GZU8">
        <property type="interactions" value="787"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663643.1">
        <property type="protein sequence ID" value="XP_050519600.1"/>
        <property type="gene ID" value="LOC126893443"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GZU8"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028154884.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35826" checksum="E5AF935584C0936C" modified="2020-12-02" version="1">MVKDEAPSNTRLTSFKLPRDLTLGPKKAKKVFVPNLNAVRKKETPKEFNKRDDRNKNGGRERRQKPRDNTPKFVQSSGIFSEGVGADVVRVRSSEGRSDKENDVAPLLTMPTIKKNSFQVDQKNEDTVFKRITDCDEESDDEKLPFRPISWENKFQNPLYGKKETNGIKSDSLEPSLKKLKLESSEYVNGVCVDSHEFLIEDKYNYDMPSMSLWALPDSFAGKGLSDDPNCKKLFDFGLKDMQEGQIGKIVIRKSGKMEIQIGSTQYELIQGDCDYKEEAIAVDLISSKTKAKSAVLGNIEHRYFLAPDWDRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9N3</accession>
    <name>A0ABM5I9N3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128082.2">
        <property type="nucleotide sequence ID" value="XM_028272281.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272281.2">
        <property type="protein sequence ID" value="XP_028128082.2"/>
        <property type="gene ID" value="LOC114324431"/>
    </dbReference>
    <dbReference type="GeneID" id="114324431"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF167">
        <property type="entry name" value="LYSOSOMAL ALPHA-GLUCOSIDASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="837"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="850"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128082.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122062" checksum="BC75002C3F96C8B3" modified="2025-10-08" version="1">MTTFIQQQNELREDEDETATASVKWTVWTILCKTTIVGWFFTFAFALIVPVLTYYLVVNLGTYKEVDTFTCFVNSTFRVPCGKVNISEHECVKLACCYDKPTDSCYHYLPSRYSYDLAGSSYKASRSSSPFNTTAIEEMQISVNEISINKVSIILHKPSTSIVENTVNVREYVVRKAAEKLMVEIFRPNGDRIFSTAKGPLIASENYWEWTVHLTDHSLFGLDKTLLQRHKNSTISKVFYKNKNDHSNFPVIWAYHRGQFHGLTVKHDGPLEVSILTSNLIILKGLLGETIELVLYTGPTPADLHQQHLEDSEQLDVPEWLLKTHMCRKNEKFLNVSTLVSNFVLDSEADSFCIDENLLMGILAERANDTSYQDAVQALITPLREKGKKFLLSVPPQVLTNSDFYNNASSLDLLYTYLNKTIYQGKYLDQDVSYIDYSHENIQKYMEVFGTFLEDFFNHTIDGLVLTDNWPANEEFKMDNDSFPYFTKALQDAMSYTIQWNTTANDILHIQKHNSYGGYQYKSLKDYFKSKEIFILSATKSISQVEPMIIENVETSWTNLRKYLDSVLFDSIIGNHLVSIPVCGDTNVFDTSIQMKLCLRWYLIAATMPMFRISAPKPWRNPDDLSAKYDQQTAQSALDTRNMLLAYYNGLISSNEPVIRPMFYDFYENTTTFSLYEQYMVGKNMLVVHPLTADRTKMNVYLPPAIDVWYEFWGGDIYKPTKTNPWVSISVTEADFVAFIPKGSVIPLIDGNTVNLIVALNFTSSKRTRSFIESSGSATGFMKTDGISITFTANIKSVDISSSSDKKWSLHLGYVKVYQYLNSNKPAYYDVNRSIDQDTQNMPYEPPPTTTTESTTSSTTTSTTTASTVTESTTEDTGTTISSTPTMESTTGSTGETDSTSSISGSTTEDTGTTSISTPTRESTTEDTGTTSTSTPTMESTTGSTGNTGSSSLISEITTADTGTTSSSTPTRESTTEETGTTSTSTPTMESTTGSTGNTGSSSLISEITTAHTGTTSSSTPTRESTTEETGPTSGSTATSESTTEDPGNTSSPTPTEASTPEITITSGSIPTAKSTTTITNTETTIITSTDALITATSNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IA78</accession>
    <name>A0ABM5IA78_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128414.2">
        <property type="nucleotide sequence ID" value="XM_028272613.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272613.2">
        <property type="protein sequence ID" value="XP_028128414.2"/>
        <property type="gene ID" value="LOC114324771"/>
    </dbReference>
    <dbReference type="GeneID" id="114324771"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33173">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33173:SF2">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128414.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1212" mass="138925" checksum="16B20E865D03FF73" modified="2025-10-08" version="1">MGVDCECASVVLGGVYIPLNSSEDIYLGHCSAVETIRNNRPDVPVYLFGDYNLPLASWAHSNEEGLLVDCQENYPAKLICECFSYLNLRQSNIIPNQCGVFLDLIFHRIEDYQKLLLTMEYINGLLKSFEAEVPAYLKSLLIYNGFDNLYSLSQFNIDEDIERMECYARDVLSKVLKGEEKKAMFGIVSEECSLFKIPEGHKKLLRFVKEESEKKIKLLKRPLLCERSEGCPAEKTFPKKRRTVTNKSTSRSESGNEGDGFCTPNDGCVSQDEEQVNYAMQHVLNISRSYIDKFSRNEFDKGKISEERLQDVLNNSKNLKVKMDGEFTAKISCPLCTFISSAYSVKNSKTGRKWVISNFLRHYKIHFKDDGTNLTKKLPIKPQKPEIQTTILNFIKKDANKKCDLNQDFEDPRGNLFDLTDPNTDLNYGASTSSGLHLELTTELSQNDSFIDQNYEIHDEAQQNNPNGVFLHYNTDLDTDSPTDNQSSSQLRTIVVNDFSTEEHQGASQVVNDIPVSELEYNPDNSSPLEDFFFLDNVAEINQSNNGSEKVKSPKAKSLFDDSNSRRERSLRILNELPYHQTQITTFLNTINHAIDTNPEVTNTSSILTENQGINKFNYGTKGLLKYLLDSAIRNSKNKSGHTNKFDDGMKRFWLYIFISAGRMSYEILHSNLKNILPSVTTIHRQLEEMNNILEGEVRIEDLKLYLQKRNYPPIIFISEDQTALIKKVQYDSASNQMVGFVAPLQEQTRFPRINKFPVDSVSDIENAFKNKTLAINAYIFMAQPLVDGSPAFCISIFGSDNRFTSEDVYKRWQYLIKEAGKHGITILGFSSDGDTRCLKSMKIISKLSFTSLNPYSPYFQANYNLENPAVFQDTIHISTKLKTRLLNENISMNMGGKRVSIDNIRYIIENYPRDKHLLCKSFLESSDKMNFNAIDKLSSEHVTNMLKEVPNAEATRQYLILTRNILDAFLLKEISVERRVYLIWYSTFFMRIWKAWLKKNGENIQKNFITTNAYTCIEINAHGIILVIEKLRQNGISEAFLPWLYSSQPCEKVFRETRSMSSTFSTMINYTLLDVLRRLKRIQAMHEISTDLGPNFRFPRQENKRLGNNSSVFKVTEFPSTDEMINIIKKAQEDALSDAKKIGMEMNRDCCIEINLPTCDNPEEQEEVQGSIIITDTISKEHEPDLEPTFLMKTGSFLNIPLHLIIMTLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAZ9</accession>
    <name>A0ABM5IAZ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-nitrophenylphosphatase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128906.2">
        <property type="nucleotide sequence ID" value="XM_028273105.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273105.2">
        <property type="protein sequence ID" value="XP_028128906.2"/>
        <property type="gene ID" value="LOC114325150"/>
    </dbReference>
    <dbReference type="GeneID" id="114325150"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF4">
        <property type="entry name" value="RE04130P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128906.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35275" checksum="9117E890CA07C2E2" modified="2025-10-08" version="1">MTTKSLKNLAEVPKEEQLNFIDSFDYVLTDLDGVLWILWKPFPDAVECMDNLRTIGKKIGFVTNYTGAPISVLFERLKNNKLSQNIEELVNPYMAVVAHLKKINFQKKLYVVASKQYKENLKKDGFNVADDPPQEIEESVKGIFENIQDDEEIGAVLYDFDANLTYIKLQKVLTYLKRKDCLFFIAAADKALPVGPIGPLIGNKFFYTCLSEISGRQPVQLAKPSHLYNQYVAEKLNVTDPKRTLFIGDVINEDMGFGTVGGYQKLLVLSGTTKMDDIKDWKHPEEYKPTYYIQNLSELNKIIKTVHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDE5</accession>
    <name>A0ABM5IDE5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130369.2">
        <property type="nucleotide sequence ID" value="XM_028274568.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274568.2">
        <property type="protein sequence ID" value="XP_028130369.2"/>
        <property type="gene ID" value="LOC114326257"/>
    </dbReference>
    <dbReference type="GeneID" id="114326257"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130369.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="270" mass="31515" checksum="BEF18818EDF5684F" modified="2025-10-08" version="1">MIPDLWVKGNAITQILTKQKLEKYGHLLKWKKNEAILEFGAADGNTSANSVLPALPKDYKEYVLTDISPNMVEHMKKNLSIPRSKIIQHDIGTIRLQDELKNKFDHIFGIFVMHMVPNPRQSFTNIKEMLKPGGQAFVSFLEHSPTDNAHHRLLKHPKWSRYGHMLSAYYYSDNIEESYKKDIDVAGFESYSFHVEKDYPIWFENDEAIKSAFTAVNNVLSRIPEELREEYLRDYHKEAVRDFKILEKDGKQVLNLNNMKLFVAIMNKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKE7</accession>
    <name>A0ABM5IKE7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine 5'-monophosphoramidase HINT3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134848.2">
        <property type="nucleotide sequence ID" value="XM_028279047.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279047.2">
        <property type="protein sequence ID" value="XP_028134848.2"/>
        <property type="gene ID" value="LOC114329811"/>
    </dbReference>
    <dbReference type="GeneID" id="114329811"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="7">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134848.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="140" mass="16178" checksum="91C1EB95AD7054E4" modified="2025-10-08" version="1">MTTDPNCIFCKIIAGDAPADILFQNEELVVFRDIKPESKHHFLVVPKKHILNVNSLQTNEDRLLVERMLEIGKKILAEHNGDLDDVRIGFHCPPFNSINHLHLHVISPASEMGFIKRQVFRPNTWWFQSVDDTLLRLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IM97</accession>
    <name>A0ABM5IM97_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136321.2">
        <property type="nucleotide sequence ID" value="XM_028280520.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280520.2">
        <property type="protein sequence ID" value="XP_028136321.2"/>
        <property type="gene ID" value="LOC114331045"/>
    </dbReference>
    <dbReference type="GeneID" id="114331045"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136321.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="22528" checksum="68DA1D7F2AFBF991" modified="2025-10-08" version="1">MRNASDIFCLNEDLTDGRQIFSINGYSPMKLKRRPRSSQSNGFVYGSSKPINNFEVGDKVMEKQDLEKLNGSDEGTEQDVDVVDNFNELNLKEDIDEMDELSARHEMGDETIVQSSRSVPITPIDTREFNIISGRSTASTVRKSINSGKKQSSRGKPSTSSEGVLCSTSSMLRNPITGVGMETTKYRKAKKGMGSKNQKWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IN11</accession>
    <name>A0ABM5IN11_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136862.2">
        <property type="nucleotide sequence ID" value="XM_028281061.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281061.2">
        <property type="protein sequence ID" value="XP_028136862.2"/>
        <property type="gene ID" value="LOC114331472"/>
    </dbReference>
    <dbReference type="GeneID" id="114331472"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136862.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="758" mass="85976" checksum="5A4F09164133CF73" modified="2025-10-08" version="1">MEPSKKNQKTLFSFFSKQPNEDKGEEVNDFGVSLSGKNSTSLRVSSDEKSDLQAGTESNSSVSSSSNMHEHDEQNKSEWPSIWTIDMWERKTEAFPWLGCKNGSLGCTLCSTVSHLGAFKKERTSISKEWCTFAITFNGSSKSAQLTSLRKKIFLHKQSSAHLTAESITAKANEETIENVCDKMNVSNLESTIKVFRSAYYLAKNDRPFSDYSKLLQLQKMNGVDIGVGLHSRFSATEIIDHISHEMKKRITQQVKSISGKISILIDESTSLSDTSTLIVYLKCETSKDLPPNVLFLDLIELPNQTADSIFEALLGCLKKYGFDFEYLKENLVAFACDGASVMLGKKSGVVEKLLQQFPNIVPWHCMNHRIELAVSDSINDVGAINHFQMFMDKLYTLYSKSPKNQRELAECASELDLQLQKVGRILGTRWVSSSFKTVMAVWYGYQALYSHFKKAQEDKNRTTTERAMYGGLIRRLTSTQFLSDLAIMYDILAELTMVSECLQNREATVVYADKLIRRSIAFFECLKEKPGTKTLEAKRAAITGNFCHVPLTSSNKITAINDQQLLSSVINNLKRRLFTTRSSNEPSNKATGNNYDYEKEYESLLSELKVLESNNWPPEKYVGYGEQEIEHLCARFRLNANKIKNSFRDYLENSTTIPKDLNPLINCTKLIPCSSAECERGFSHMNIIISPTRSKLTIEHVSALMFIKLNGPSIQTWKPENYVKAWLRRHRTADDTRTRRANLQPDKEEEDAFAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IN13</accession>
    <name>A0ABM5IN13_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Roundabout homolog 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136865.2">
        <property type="nucleotide sequence ID" value="XM_028281064.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281064.2">
        <property type="protein sequence ID" value="XP_028136865.2"/>
        <property type="gene ID" value="LOC114331478"/>
    </dbReference>
    <dbReference type="GeneID" id="114331478"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF52">
        <property type="entry name" value="PROTEIN SAX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="130"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="219"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="318"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="430"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="542"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="641"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136865.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="110603" checksum="A0C098186F061300" modified="2025-10-08" version="1">MNSKKEQDAGVYWCVAKNVAGTATSRNATLQVAVLRDEFKVMPADTHVAAGETALLQCGAPRGHPEPNLVWKKDGKDMDVDGRRIRVVDGGNLMISDVRQHDEGRYQCVAHNLVGSRETPPATLKVHVKPLFNKEPQDIVALTGQKVVFECSVEGDPTPNVLWRREDGKMPIGRARIMDDKSLLIDNVQTTDEGLYICDAENLVGTISARASLVVNSPPTFIERPKDQKVSLNGVVEFHCSATGNPPPSVFWSKEGSQILMFSDNSNGHMHVNAHGTLRIQGVQREDAGFLVCNALSVAGSNSVRAFLQVTSVADLPPPIIQIGPANQTLPLHSMVTLHCRASSPEGEAPKIRWLKDGKALFGSNLPSRYTLSSTGTLDVDDLRLDDSGQYTCSATSESGESSWSASLNVVEGTSIPLHRSPDPSTFPKAPSIPRILNSTESSISLSWDSEDDENTLVGYTVEYWSPDLQTGWVIAAHRIQNPYMVVHELKPDSSYVFIVRAENAHGLSPASPVSKISRTLANSRSLPSSELDTARATLSTKLIELKEAKPQSSSSVKLIWNFSDNDYVEGHYIRFRELSGGSHNYNILTVLDVEAKSYVVANLKKFTKYEFFISPFYKSVEGQPSNSRIAQTLEDVPSAPPDSITAGVFNDTAGWVRWSPPPPQHCNGIVTGYKIQIKGNIVRSMTMNASTTSILISNLTAGGSYTAKVAALTIAGQGPYSNPVPLLTAPRAQSPRTLGPFVPLVRQTWFVALLAVLVLLLLLGIGVLLYLKRRQSLSKQLGHLNVPVVNASQLNAKESLWIDRGWKATDCDKDSSIPLAQPADYAEVDTKNLSTFYNCKKNLESPTPYATTMILPPPNWSEIIPPPPDHPPPDCPRENPPVPPPRGGGSTCGSAGGYGCYSVHVPNQCGKIQHARARSCNNCDAHCSLASGSSGHRSNSRGYCNNIPHSCDTKIWFNQHNWDNEDADCEDRHSCTSSHDTTCSCSESSCLYAEAGPSNNPRPLAHNPQVNKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPL2</accession>
    <name>A0ABM5IPL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_028138214.2">
        <property type="nucleotide sequence ID" value="XM_028282413.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282413.2">
        <property type="protein sequence ID" value="XP_028138214.2"/>
        <property type="gene ID" value="LOC114332584"/>
    </dbReference>
    <dbReference type="GeneID" id="114332584"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="1734"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="2444"/>
            <end position="2757"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="2771"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2727"/>
            <end position="2751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2733"/>
            <end position="2743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138214.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2803" mass="323389" checksum="D2063244AB785E06" modified="2025-10-08" version="1">MSTGELTDCCIYLESDKVSERKKYCTKLNSILEIQESTNILNRGKPVSWKRLIKSLQKCIKKDAEKTFEDSKKKSGSSNVPANYLSIELFVQVVTKAIKEDGEININELVRYILGCMDDIQMKKCYEKQLLDILQKCILSNSKCRGALEEEDWEEIYCKLKRLLEEYNDNLVVSHCFMILIKYGPTHGLPPRLLRKEFDFMTKICQKVTLRSPKSIQEDIIETALDFCKHTAKDNRVSCCKFGEEIFTSLSGLYEMNGKPEKTKELLVQFFLFQMIIHHPNGVPEGHSAAYANSWDNWKKIVKTIYSIISKEISLYFKCYQKNRSFFKQENGGTSLCSVFSRLHAETVKQLFMCPDLDVSMSIDCSYNPSQKRQKVNLSMRGLIDQIQDSKNWLWIHLVRCLIQIHPSVIEIDDYVALLEILSSIQIEKNEHDIVENVYYCLSTMLHMENSLEVGFHQEKLTKLWKIIGENTTRAFGLNQHKDATEALLEELIGRGIVDFDDILPTYQSDVINLSLQSIRTYNAGLHHMILNNDLQKKECIIRSVLKPQTHTGCHYLRSKDTAAFLVRLILKQWQSKDQQPKSEAVDEYDRLKEIYFKSLLDEETLTLTSSIQTTDVKASPDIQRECVTLLATMASNFVTDNDSVEVLLSKIALLVNIASCVTEYQIMSEEDSKSCWFEMIKGLFEADTLTEFNLTEYKSEREIKRLIDCVNILNDLFSLDVAKWTMDNLKELFPFQLLKKLFDVLNRLQIDQNRSSTLLPKLKICILQALSSFGCLCGNVLSTNQKNVLEVLAVPNYSNNNDDDYKLCMSFLKTVTLSQPGVLTDNILENVLQCIQELCMERYQDKAEDILHMLHGMFPHIAKCRNMEFKNLSVMLLKPFYDNIKRYGPSVKLALLNCLQKLCELDPCSTFTKWEGTEIIRFVPDFLISDYQEVRLKSIDVLVTYYNKNSDTSNIEDIHRQEEIFVKVYEMSVSVFNIDEITTNERRVDEVISRTASVLLTFGEIATNCDNWIEESIYSLMKIAYTKNIDSLDKIIKIINKRKFQDLESNILETYISYLIQKWCADGYSFENFQYTLFNCSTKYEFFKKYFSKCAPILMTTDAADDIMKVAKELLATDTKLVEKTAAKIFTRIICSDLDNMTANILVKNKSLLQYSKVMEHTSLKDALQNNLDQIVVGILEFLTDENGIKSHFGETVIFFVKNLSSVDVGKCFKFLETFLCNNEPLANFLTSSNLSKFENVLLELKCNIYKSQVFMDKLKCLYAYRFFVNMITSVLTPDSSWRYFFIRDVINTLFNIIDNNQDCTRIETATFRFLNNFLRQIFKFLATKDFFHDTVSSLKKFYVTKSSINKECKELLVFLVVDNARYFEEQIKTLDSFPDHEDFYAIRKLQKKIKYGDQEPGVEEEIEQFLNHKDILTKGDSLHHLREILCDQKDKLTGLYDKLQNIRGFSEDCEQSLVHRLVCTLSQLSYSADQNVSFEAARCLGEIGPINLHTLVLQAEKNLVHVRQSPFEVICGTSIFLLTKYLIDCDEDVIRKSSKMLYVALETKEGKKLVGEGADLGYGPINKNYVIPYYPTSSSRPQKVNVDLNGFIEKIDSDELWCPRQNVTHNSWINLLISSMLETFVSNDFLNGLKEICKSKVEFSEHLLPLVVNLLVSVGHRSVITTLSKNIEYFFSEHWRLTVRENTKEELIAVNKKSVKCMLNVVNYVRLMKNCNPYKSRPLDELTVNSLKVAKAAAFCANHFCALYYSELWCQQIVENLQSENPVYCEQRSTMIDFIYEHEEPEVGETLHNILRNAYKSIGDFDALPGCGISFLLQPKYRVEHYKEQGKFDQVIQFYANATTSLGSSSKELMDSFKSNSLYQIPVICSKLDEPEYECLWRLGHWSFEEKKRNVNKTTIVHEDFEKYRFYSLKALHDNNQCAFEESFNCQLLNVVNDIKNISLESSHNLYPALTQLQSLVEIEDFYCFVKNGNRAPLTSKWKLQDKFIRKNDFQYVEPIFTQRLVMLRDYLQKEANDDVMRQYVIDLSLDFANRAKDEGHFKESSTILENLKGISGLNSETLSKIDLVDVQLSWSVNNTLVARQILNRLCKSDQISPRLKATALKLTGQYLSETNAENSSTIISDYFLASIQQMGTVRSDVEDRKNVMDTYDKLALFADREYVQIMTYMKSDLFQKKIATMEQSKKAASSIQNQRDRTYEEAKAAAVHTRNSSIDEQEIESTKMECNQFLKLALKYYLLCLVHSDDKDIRIFRIMSLFLENRKNLEISDTIKAHLPSLPSYKYIVMLPQLIPHLSTDNEIDIFNKYVSVIIEKCAMEHPHHTLPLLLSLANAHKDREFDKVPTKTSSNDARIATAKELIRKLRNKGLSQSIDRLNQVSTALINLAYFEHPKGNNDTKKEYDIPRNQIITKIENYVDVLVPTYQLPVSVKKDYSNIVGIVSFKSKYKIAGGVNVPKRILCRGTDGKYHSQLVKGKDDLRQDAVMQQVFNIMNNLLSYNKTTKHLRIRTYKIVPLSMRSGILKWADDSMPIGEYLTGNGKDNLGAHQKYRPTDKSPNTCKSVFLNCARKSPEVKLEIYKRLCKDLKPVFHHFFEEFFSQPAIWYERRRAFIHSVATTSMCGYILGIGDRHTSNILIDKTTAEVIHIDFGIAFEQGRVLPTPETVPFRLTRDMVDAMGVSGVEGIFRKSCERTMEVLRQNAQTINTILEVLLYDPLYAWTVTSAEANKRQTEGDEEVEPESTESPEVPHNVSAERALLRLREKLQGTELGHPRSIEHQVGALIQQAVDPSNLSRLYHGWQPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZ50</accession>
    <name>A0ABM5IZ50_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151140.2">
        <property type="nucleotide sequence ID" value="XM_028295339.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295339.2">
        <property type="protein sequence ID" value="XP_028151140.2"/>
        <property type="gene ID" value="LOC114344505"/>
    </dbReference>
    <dbReference type="GeneID" id="114344505"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151140.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12779" checksum="9ADC96BAB51BB242" modified="2025-10-08" version="1">MKHQTIVSDFLESCKEINQPQTRVVEGKPATLLEKVMGTGYWICPSKEDRKSVYTYIVKARICPEHKIRDQPYLKLDTRGNIILEVSCISCVASSGVRKQSCHCILNLTPPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZG4</accession>
    <name>A0ABM5IZG4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152304.2">
        <property type="nucleotide sequence ID" value="XM_028296503.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296503.2">
        <property type="protein sequence ID" value="XP_028152304.2"/>
        <property type="gene ID" value="LOC114345708"/>
    </dbReference>
    <dbReference type="GeneID" id="114345708"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="892"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="911"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152304.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129621" checksum="D97037DE37516C15" modified="2025-10-08" version="1">MANCFTFAKRKSIVVEDSTWTNQVVTQSPLSFSNTEDSLNESYATAADENETQYLSVLESTTGDHTLEDIHDITLGSQKLLIQDTIGLNVETISQDNFNVAESEEQQVVIFNVEGSNELYGIQVAQDNDGNVHRYQFQLRKTGDGQLEPMPETVQLLANEEDQQVTEEQQDASELNADQINEEEFEEPVYLQAKLEQTDGSTQSHLFISKQTKKTNVKKEVTNLYREDLEENYEEADINLKSEINLATLKEEFIQQQNEECQDTEEALSVNFDEDFTSEATSYDAAEINHSDQEAVIDFDNQIIEEQYEDGAKPQNNRLHFEQLFIHDQPDEIRQYHEEFQPENEESSNILIIEKDAENNESEHEDYEFVSQLPVSAEDINEEESVDEEAGVWYSEPEIPVESVKLTENSLLKTTNILKQPTNTVKRVDPKKKAILYYMVPKTDQKENVNSIPYTNTNSNPRSLLKNSLDLTKINEDNIKKLQREKLMERRYARSKEAMQAKMFNNFINKTTIPHAPVRQGRLPRKQQIKPVDTRRNEEIIVQEVMVSSKGFVESVSDRLKNLEVTSIVELSDSDDDKDLTNGTKKKKKHKKTNSSSTAITSDSEGSVIEIIHTDDETDDTSFIVNTVKKGPGRPKKNTEDISKRSHELETNKENGSGSSTESTPSKKSRTDDSSEVESDTNKQDTPEISCPLCSKSFPNQNSLSTHLQHHNLENTLRSNTKRNLEYRHNCDKCQQSFKNSILLKKHVCNISKELKNTHKCGVCSKTFKDITLFNIHKKSHIKENLIKTTTSVTISPKKFTSRPSTALKAPVSFNCKVCSKVCSSQIILTIHEKSHKKFVCANCNTSFTSKILLDSHVRVKCVKNSSPKDRRLSFKIRKSFISSPRLSSIRGKSLNTFKPPGATSTKNINIPASSARKSIIPSSSATRSVNPSNVVRKSTIPSSSARKSIVPISSARKSIVPSSSARKSMFPSSSARKSVIPTDSARKSFAPRSTSASSSVGIPGHTSIRTKQILNPLFKDSGNTTKNANSDLNTSNFVKNLEVEIQCDTCTMKFTNWTSLFKHKVKNHGLYTPDQKVLKPKRKTIYKPLTLHGGIPANEKLNKAFQAFRRNLAMINTTEELKLGDKSEQKEDNVLPQIVVSEPSHTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH10</accession>
    <name>A0ABM5JH10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497226.1">
        <property type="nucleotide sequence ID" value="XM_050641269.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641269.1">
        <property type="protein sequence ID" value="XP_050497226.1"/>
        <property type="gene ID" value="LOC126878514"/>
    </dbReference>
    <dbReference type="GeneID" id="126878514"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31809" checksum="0FC6D2417B895E38" modified="2025-10-08" version="1">MDFCITQKQVPTVKRIYRTFAEEYNYSGSIESLRTVIRKMGFRWRKTRNNRKLLMEKPNIQHLRLNFLRSMKRYRNANHPIIYMDETYVHSSHTYQKSWSDSSNKGIQKPVSKGQMLVIVHAGGESGFVKNAYLRYKPTIKTGDYHDAMNYDNYKKWLQDKLIPNLPPNSVLVINNAPYHNVQTEKCPTMSSRKAEMQQWLTTQNISFTDDMLKLELYDIIKLHKPLFKTYEIDKILEDKGHSVLRLPKILCGFESYRVSMGFYEAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHG1</accession>
    <name>A0ABM5JHG1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497375.1">
        <property type="nucleotide sequence ID" value="XM_050641418.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641418.1">
        <property type="protein sequence ID" value="XP_050497375.1"/>
        <property type="gene ID" value="LOC126878607"/>
    </dbReference>
    <dbReference type="GeneID" id="126878607"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="84374" checksum="E39F37BFB0AFEDCA" modified="2025-10-08" version="1">MPLTREQQLEIRSAADVSIKQLCQDQTFIKSIVDSVSAGIVQILNSKLDVYEKKIDDLKTEITKIKTDHEVEIQTIKASLIDLNKKGDSFDMIKITTELNQIKRKESNILIFGVPETEIHLQAYIENMFTAISMNRNPQLNGLHVSRLGLQPSANSNKCRPIKVKFPNSNQVTNFLKLNPKLKSLDCYKNIYMRSDQTVMQREYTSKIKKELSDRLAAESWLRDGVRSSELFPEDTYSVYRKDRSFGKFGGGVIFAVNNNVCHSEQHSVVFPIEKIDVLCVKVFKTNIKPIFFITVYIPPNVTFSEYSDFFDYIETFHETHEVVLIGDFNLTDLAAYYVNNSQITPLINRFVQLLNYTDSVQCNKIKNIHGKILDLIVTPSVFSCEVTPEVNALVPIDYHHPALTCYFPYEVKEDEYFVPNQKRLNFRKYNVNKFNKLLTEMDWSHLKHFSDVDSAVDSFSLSLQEIIDKCVPLSSTRSQKYPAWFTSEIIAKVKRKHHYLRMYRRSKYCFYLQRAKDLRRTIKLEIQLEYKKFIERSQNSFKSDARQFWNFVNAKNNKSRIPGLMKYGSDKFTTSQDIVNAFANFFKSVYISDSNSSPSVTSYFNYNPSSYFNIGKITSNDIIEGAKKLKNKFSCGPDNFPVSILKCHVESFIEPLVRRRTVRTEDVVAAVERSIEEDPLQYTYTPSCTAVEYVSIHFMEDFVKRSWFTCLQISTRAGIEATRSPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJJ3</accession>
    <name>A0ABM5JJJ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498108.1">
        <property type="nucleotide sequence ID" value="XM_050642151.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642151.1">
        <property type="protein sequence ID" value="XP_050498108.1"/>
        <property type="gene ID" value="LOC126879156"/>
    </dbReference>
    <dbReference type="GeneID" id="126879156"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="152"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="887" mass="101339" checksum="82FAC6F31FD5FF72" modified="2025-10-08" version="1">MDNSGIVFYPIINSIQRMALYETKAKFYLVGSNNTQTRFRVLKIDRTEAKDLEIYDDKVEYTAEEIRNLICMIESGNRRAGGGFSKVISAFGIVGFIKFLEGYYIILITKRRRVALIGHYTIYKIEDTTMVYIPHESVRVVHSDESRYVKMFQNIDLASNFYYSYSYDLTHTLQHNLTNPKRFVATSESEEKEFNLSEKSTDNLSSSIISNSSSSDNGETQNYGVRTQPHNKFVWNMHLLSDAVKAELHPDWVLYIIHGFIDQSNINVFGRSIYVTLIARRSCRYAGTRFLKRGANFQGDVANEVETEQMVHDCSISYFNKSHFTSFVQMRGSIPGHWKQEMGKMVAKPAITIDFYDPFAETAGAHFNELLKRYGAPIIILNLVKQHERKKQERLLSDELSSAIKYLNQFLPVEHQIIYQHFDMARKTKANGNVMGHLAEIAKNAVMKVGIFHNKPKFYNQKGNTVVGQYKNDFGSLQTGIIRTNCVDCLDRTNTAQFAIGKCVLGYQLCALGILDTPNLEFDTDCVRMLESLYEDHGDTLALQYGGSQLVHRIKTYRKTAPWTSQGNDIMQTLSRYYSNTFSDAEKQNAINLFLGLFQPEEGKPQIWDFTSDYYFHHKPILFSLKPLTMWWDGGVLKSLPYAYNDLTKACSELIQVHSQDAEMIDSFVEYYRPYELTMLSDVFALKVPNSIRDFMPNFTTNYSPFTVRVRPVRRREEGNSKTAPMKNPSLTGQSSTCSSTASSTSSSSDEETVDEEESSNTNDSLAASSKESSPEPITFKSLFPSMKEVYGTELKRPNPEDIHMYKKYVLIGKKANGTAKNVFQSITVNQKMLHELSTDSVFQVTPPKVSEASIDIYKKYIEVGKHGGFQPTRSDLLIYERYANYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR00</accession>
    <name>A0ABM5JR00_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500363.1">
        <property type="nucleotide sequence ID" value="XM_050644406.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644406.1">
        <property type="protein sequence ID" value="XP_050500363.1"/>
        <property type="gene ID" value="LOC126880510"/>
    </dbReference>
    <dbReference type="GeneID" id="126880510"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30288" checksum="E4FF714962AF1652" modified="2025-10-08" version="1">MLLEPIANTITSVEGDTPTISKCLHLFKKMVNTSLENVTKSPLLSKEEADTRAIFENRKKFAIYSVHFVANLLDPKYRGCELSSDEMTDATEVIYKVAQKMPDVDEAAVLADVVNFIAKEGLFKKAFLWNEDTIAAISPIAWWSGLCSNTALSKLAIRFLELPATSAACERSFSSYSGIHTNKRNGLTNTRASKIGYVAHNLKLMAELQPSESSSSESIAGPSFTVNPALESEPEPMIISNSDQSESVFESDEEEASESEENADSDGTDQCSFKGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT99</accession>
    <name>A0ABM5JT99_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related protein Rab6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501161.1">
        <property type="nucleotide sequence ID" value="XM_050645204.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501162.1">
        <property type="nucleotide sequence ID" value="XM_050645205.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645204.1">
        <property type="protein sequence ID" value="XP_050501161.1"/>
        <property type="gene ID" value="LOC126881139"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645205.1">
        <property type="protein sequence ID" value="XP_050501162.1"/>
        <property type="gene ID" value="LOC126881139"/>
    </dbReference>
    <dbReference type="GeneID" id="126881139"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23574" checksum="D8CC3B0E1D31D8E8" modified="2025-10-08" version="1">MSTSGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNANSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVSTEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMDSTENKPPEDMQEVVLKDTPNELKDPDGGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVC0</accession>
    <name>A0ABM5JVC0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501888.1">
        <property type="nucleotide sequence ID" value="XM_050645931.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645931.1">
        <property type="protein sequence ID" value="XP_050501888.1"/>
        <property type="gene ID" value="LOC126881582"/>
    </dbReference>
    <dbReference type="GeneID" id="126881582"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="245" mass="26472" checksum="785613BCCAAD102B" modified="2025-10-08" version="1">MRQESVVLEEWDGVSVAAGSGSSTRPRWRRSAGQQRSKLEAVSGTANGPRWRRSAGQRRSKLDGNQRESNGARWGRSAEQQRSKVEAISGTATVQGGGDQRDSNGPKVEAASGTATVQGGGDQRDSNGPRWRRSAGQRRSKVEAISGTATVQGGNGQRDSNGPRWSRSAGQQRSKVEAVSGTATVQGGGGQRDSNGPSRGNTITGTADNDSIQFQHREPCFWVCRRFFESSHQGYQIMCRTLHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVG5</accession>
    <name>A0ABM5JVG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501930.1">
        <property type="nucleotide sequence ID" value="XM_050645973.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645973.1">
        <property type="protein sequence ID" value="XP_050501930.1"/>
        <property type="gene ID" value="LOC126881609"/>
    </dbReference>
    <dbReference type="GeneID" id="126881609"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046413935" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18230" checksum="1B05853359FDA07F" modified="2025-10-08" version="1">MTSKVVLVLVLALLAFTAAEKQETRSKEIGNALDGIFRSFIPAEISSRNAEEHLRRRSVDSQIGIDINNTVEKLVEAVSELIHINVEVINNPQNRDLPLKAARDVVFEITSNLNEFVKFILNYFLNSLTQMIGQLILSPVRSLLDYLLDFMLPCGVTCTVLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVY3</accession>
    <name>A0ABM5JVY3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Acetylcholine receptor subunit alpha-like 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502097.1">
        <property type="nucleotide sequence ID" value="XM_050646140.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646140.1">
        <property type="protein sequence ID" value="XP_050502097.1"/>
        <property type="gene ID" value="LOC114324774"/>
    </dbReference>
    <dbReference type="GeneID" id="114324774"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044984454" description="Acetylcholine receptor subunit alpha-like 2" evidence="17">
        <location>
            <begin position="22"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="247"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="62390" checksum="2E5783936DC9FAEB" modified="2025-10-08" version="1">MKLEWMIFVLYLFCVLDFCLCNPDAKRLYDDLLSNYNRLIRPVSNNTDTVLVKLGLRLSQLIELNLKDQILTTNVWLEHEWQDHKFMWDPQEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTKAVLRHTGKVLWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGNQIDLKHINQKLGEDKVEVGIDLREYYPSVEWDILGVPAERHERYYPCCAEPYPDIFFNITLRRKTLFYTVNLIVPCVGISYLSVLVFYLPADSGEKIALCINILLSQTMFFLLISEIIPSTSLALPLLGKYILFTMVMVGFSVVITIIILNVHYRKPSTHRMAPWVRSFFIKSVPKLLLMRVPKDLLTELAANKIPLNRMSLKKRELDIMPSSRSSSSSTSSSSMNRVSGCNGLHSSTTTARLRGFAGTLSERLGYNGLPSVFSGLDESDSGTRKKYPFELEKAIHNVMFIQHHIQRQDQFNAEDQDWGFVAMVLDRLFLWIFIIASIAGTISILCEAPALYDDTKPIDMELSSVAQQQFLPDFENMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY18</accession>
    <name>A0ABM5JY18_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502828.1">
        <property type="nucleotide sequence ID" value="XM_050646871.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646871.1">
        <property type="protein sequence ID" value="XP_050502828.1"/>
        <property type="gene ID" value="LOC126882056"/>
    </dbReference>
    <dbReference type="GeneID" id="126882056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="212" mass="24548" checksum="0EEF4808B03AC6E9" modified="2025-10-08" version="1">MQLQIELDKLGIPSVGTVRPNRLKGCNFSTDKDMKKKGRGSFEELVYKKEGITLRAVKWYDNKPVHLLSSFVGTYPTSQVQRWDKAKKETILVECPNIVTFYNKCMGGVDLMDSLMALYRTKIRSKKWYLRIVFHIFFLAVVNAWLLYRRDTQLLGVRKDDELSLLDFKASIAACLCQEGKERLEKRGRPSLSIIEQEIEQKRKRGLIATLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZT5</accession>
    <name>A0ABM5JZT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503451.1">
        <property type="nucleotide sequence ID" value="XM_050647494.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647494.1">
        <property type="protein sequence ID" value="XP_050503451.1"/>
        <property type="gene ID" value="LOC126882527"/>
    </dbReference>
    <dbReference type="GeneID" id="126882527"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="485" mass="56971" checksum="A68FD9F043664F0D" modified="2025-10-08" version="1">MYMCGFHCTTCDKTYKLKKSLGDHKRKYCQKDPQFACPCCPYKAKLKGTLKRHILRRHERTKILKNGPIYVPSELATIAKSAKKKGEPYEVTEMPTEEFFDWKKIAKDMGANFNVNEKGQKVLINDIKWIKVKKGEPGKIVYKTSFKQEEFDVINITKKLRSQREKPTLILAYEQAPPIPIKKKNDLMRFHCDTCDKIYKLKSSLREHKRKECQKEPQFACSYCSYKAKLKGNLKRHILLKHQERTKILKNGPIYVPSELATIAKSAKKKGEPYEVTEMPTEEFFDWKKIAKDMGANFNVNEKGQKVLINDIKWIKVKKGEPGKIVYKTSFKQEEFDVINITKKLRSQREKPTLILAYEQAPPIPIKKKNDLMRGFPCNICNKLYKLKGSLTRHQKLECQKEPNIVNCNFSKLQLFLYFIYFLGPFVCLKCNITYSQAYNLRRHIQFECGVERKFTCEFCNSKFKRKDHLLSHKRSLACKRMQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K042</accession>
    <name>A0ABM5K042_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503556.1">
        <property type="nucleotide sequence ID" value="XM_050647599.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647599.1">
        <property type="protein sequence ID" value="XP_050503556.1"/>
        <property type="gene ID" value="LOC126882625"/>
    </dbReference>
    <dbReference type="GeneID" id="126882625"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="486" mass="56931" checksum="3091D8BC9A544C05" modified="2025-10-08" version="1">MPMKASDFRQLYRKRDIIEQRLNNFIKFIESMTNIAINDLSEDHFSQIEWNIERTESLVTEFDEIQMSIELNCQDQDIQQEYANRQRLDTIFSKTLSKARTILKRKCSDSSSSESKRLDINHEYSGLEGVKLPPIQLPVFHGDYLTWIEFKDTFEGLIHHNKVLADIQKYHYLRASLKGDALKIIQSLDFSAQNYNSAWQTLCNRFDNSRMLVNNHLKALFEIENLNKESALGFRSMIDSVKKHLFALKSLQLPTEHWDAIMVYLVSGKLDKFSSREWEKRKIDNYLPSLNEFLEFLKNRADFLETIELSNVTKPDYKSNYQDKRSRSLLTSKSRSCNFCKQNHLIYLCEEFLKLSVTQRWDKIKQLNLCRNCLCTGHSYKQCKSFGCKICKAKHSSLLHENKPSDIHVKDNSSNNFNPNNDSENEPNKVKLSTNTSENNVNRNEIVLKNNCSNNDYVLLSTAKVRVYDRYGNTHIARELIIPFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K078</accession>
    <name>A0ABM5K078_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503592.1">
        <property type="nucleotide sequence ID" value="XM_050647635.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647635.1">
        <property type="protein sequence ID" value="XP_050503592.1"/>
        <property type="gene ID" value="LOC126882662"/>
    </dbReference>
    <dbReference type="GeneID" id="126882662"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="283" mass="32846" checksum="54DAE25E6FC8B825" modified="2025-10-08" version="1">MSSDNPMSTEHPAHDFIELFPETESVSDMGTTPVPPPSPPQSLTDDIVMEEIKGVFSHDEEIKDSEGPQPDESSIKNCNNNPGSLQENQVVMIQQIVTIPPQGTTNSLEFTNDPQLEADYDSQRFEGKKPTKRPCNSPDTERNQSDLANTIQQLMKQLEQRDKENKRVQQEFKEILEERDRENKREQQEFKDLIAELRSIIRTKDDEARRMMDQIMKLTKTVQEMTNKRTVTITKIDESPMTWEQTENEKHEESETETTVYKNKSYQKSILSKRKKREIVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2T9</accession>
    <name>A0ABM5K2T9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050504506.1">
        <property type="nucleotide sequence ID" value="XM_050648549.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648549.1">
        <property type="protein sequence ID" value="XP_050504506.1"/>
        <property type="gene ID" value="LOC126883253"/>
    </dbReference>
    <dbReference type="GeneID" id="126883253"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00914">
        <property type="entry name" value="PCD_DCoH_subfamily_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002020">
        <property type="entry name" value="PRK00823.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17559" checksum="6CBC3673B2301406" modified="2025-10-08" version="1">MTSLFMMINKIGSKNQVRLGALESPFHLFTFIRNLTLTTVDLTQKSGKSKLKMQAKLNEVERNTSLAPLFSQGWKLVENRDAINKEFLFKDFNQAFGFMSRTALLAEKMDHHPEWFNVYNKVQVTLSSHDVNGLSGRDVKLANFMEDVAKGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3C5</accession>
    <name>A0ABM5K3C5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transient receptor potential channel pyrexia-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504688.1">
        <property type="nucleotide sequence ID" value="XM_050648731.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648731.1">
        <property type="protein sequence ID" value="XP_050504688.1"/>
        <property type="gene ID" value="LOC126883332"/>
    </dbReference>
    <dbReference type="GeneID" id="126883332"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="905"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="949" mass="107610" checksum="BF19918B8805B7BD" modified="2025-10-08" version="1">MASKLWSVRTALQFLHRTSRSKENQEQQQDEDNLAAKLFYLPKLNEVQDPSDEFIDCGPSPPTENLPLIWDTYEVPENGNEVKICYHTIEQNILEHMSNAYGRISLLDEISSKRVDSKNIVGVFFGASHIELNIAFLWAAFVKRYDILENLLYLGAEINYFEPAQGLSALHLAAFSNCISGMQFLISKGCDINALYKFYTPLHCAAFGDSIEATLFLIRHGVKIDQFTNTIYEENESALHCAVRANSINCVKILICHGASVDCSEFSPIHLAADLGNYECIRYLLDGKGANVNSKTKEQEQTALHLAAIRGNPECIEVLLSKGANADCRDYMGQTPLHLAARAKDLTSVELLVMTGRANPNIEDYDQRTPVHAAIGKSAWSSRIIQTLVENGAYPNVEDQYGYTPLHIAALRGLADCVETLINYGADVTLKTKCGHTPLSIIKKKVPIAFSVFTKKLDDAVTLYNTDSLSNEPELRLDFRVILQPNHAGEMNFLYTLVEEGYKTVLLHPICAALLYVKWQKIRKYYLARILFYAIFMLALSLYVLTALSHYCYNYGNNFTDMKPEDVIELCEKNSILGRVLRDSPFVMEMQWFFLVGLTSLEIIRKLYGIYGYTSVRQYLSYPENVLEWWVISSVFVISCVYTKRTYLWQNHIGAFAILLGWTNIMLMIGQLPVFGIYIAMYTRVQSEFGRLLFAYSGLLIGFTLSFCVIFPDSNFFANPFISLVTIIVMLSGELNLDILVDNNPDNPHYLLEFSAQVTYVIFVITVTIILMNLLAGIAVDDIKGLQKTATLSKLVRQTKLISHMEKGLFNGSLPRYILEHLHVSALVSPKPSRVVLNIKPLNPKETRLPKDIIRAAFKVAKRQTDYFSGTPDTPVDDYYWFNNDITKDHCCLDNKPLIGLQEIMKRKTVEIEHLKATIQEMKQALEANQETMQQCMRTFINNRRGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3Q1</accession>
    <name>A0ABM5K3Q1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504818.1">
        <property type="nucleotide sequence ID" value="XM_050648861.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648861.1">
        <property type="protein sequence ID" value="XP_050504818.1"/>
        <property type="gene ID" value="LOC126883374"/>
    </dbReference>
    <dbReference type="GeneID" id="126883374"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="216" mass="25494" checksum="2C9E4D6421B26320" modified="2025-10-08" version="1">MYLYQRHDQFLQAAVSSLKLDSNVYSVAPSVVFLSSMFALMYIYFSRYSYSEWQVGIYHNLVFHWAYFYIARIWLVIVKLARFLIEYMDKYIEANCRKDEIIQNQILTHTCIFFVMLILSMFPLALLIPQLFHNQRMPNFFTWIVNDNIRHNTEIGTSIPYLERPPNILEQPHKRSAASYRSKISSSFINPVARGVKVSAMRISRSMMTVQRGTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3U2</accession>
    <name>A0ABM5K3U2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504864.1">
        <property type="nucleotide sequence ID" value="XM_050648907.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648907.1">
        <property type="protein sequence ID" value="XP_050504864.1"/>
        <property type="gene ID" value="LOC126883382"/>
    </dbReference>
    <dbReference type="GeneID" id="126883382"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="162" mass="18361" checksum="07FBF0F8BAFBF37E" modified="2025-10-08" version="1">MNSSKLRTTKRLQPYFRWLHSTTTKSQKVPRHGTSCEIDCCGNPLPKEKDVVVEKNLDPCIFDTWRPKIPVLKADPKPCICPPVTCKTRFCYAGMKPKPGPGELKEKGMKCLGKVSPKGIPVSHPPAMSIQKCLVCPEVRRRPSQPKLPFPDWDHDCNTFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7S4</accession>
    <name>A0ABM5K7S4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506239.1">
        <property type="nucleotide sequence ID" value="XM_050650282.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506240.1">
        <property type="nucleotide sequence ID" value="XM_050650283.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506241.1">
        <property type="nucleotide sequence ID" value="XM_050650284.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650282.1">
        <property type="protein sequence ID" value="XP_050506239.1"/>
        <property type="gene ID" value="LOC126884352"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650283.1">
        <property type="protein sequence ID" value="XP_050506240.1"/>
        <property type="gene ID" value="LOC126884352"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650284.1">
        <property type="protein sequence ID" value="XP_050506241.1"/>
        <property type="gene ID" value="LOC126884352"/>
    </dbReference>
    <dbReference type="GeneID" id="126884352"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250:SF2">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="409" mass="47597" checksum="8AD5529F28A3F78D" modified="2025-10-08" version="1">MNIGTWNLQSISGKMEEITEEIKKLDMDIVVLTETKKKGIGIEKVNNYVHIFSGVSKHERAKRGVSVLIHKKHKHKITDFEAIDENIIRVNITIKETPITILGIYAISDDEPYTNKDEFFAKVNDEITKIGNRRELIVMGDLNSRVGRKVDNKVVGPYGEINQNDNGERLIEICENHQLKITNGFFKHRDVHKYTWTQTTRNLKSIIDYIITKQNTNMQVQDTRAYRGITCGSDHYVVKSKVTCPFRYKITHNQTNCQPQPEETLEKRSYNLDSLTQESTRILYQQRLDGKLMNITETSTVEEVYGNVVVSVKKAAEEALGFNTQRKSEKLWWNKEIEALVEEKKQAYIRWLSSKQQKDRDEYLELKRITRRTTVKAKREMWDKKCQEINTYLGGRKCTETVAVTLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K842</accession>
    <name>A0ABM5K842_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506359.1">
        <property type="nucleotide sequence ID" value="XM_050650402.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650402.1">
        <property type="protein sequence ID" value="XP_050506359.1"/>
        <property type="gene ID" value="LOC114331798"/>
    </dbReference>
    <dbReference type="GeneID" id="114331798"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="54"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="848" mass="97098" checksum="0EDCD248D9B09EE1" modified="2025-10-08" version="1">MELELVKSYLQARDPSIMAYNRTDMKEVKLNLGELMESNDTEVEEQTESEEDKCINVYLRIRGDVNEYALYEIDGNSLICNVPEGSFTFRNVKSGDSMKRNYSFTKIFGPEYDQQTIFNYIIKPKVLSFINGRSSTIFTYGASGSGKTFTIVGTPEEPGLIPRALEYMFRSIPKVSQMPDVQLLPNGSTQYFSKSVMDMHEQYKNSIIDTTIVDDIRTYKRMQERLSSEPVAKVEDDPNVSVSVWVSFAEIYNEIIYDLLSLPAARNQPRQRLVLGKSQGNTFIKKLTYLNVRNGLEAYQILQYGLHNLNYAATAINSHSSRSHCIFTVSLLQTSKCSNDVYVSNFNFCDLAGSERLKKTNNFGDRLKESNNINTSLLVLGRCMENIRKCQQIKDSRLIPFRESKLTQIFQNALLGHENVEMIVNINPSRNMFDETVHVLNFSAIAKTVIVKEELPKPIKKETRFSLLMKAENSPRLKEIVSNKLEVEKLKKKYNRAKEEIRRLQTVVNRLNEELRDGLTSDEKSEEIKHLHRAIDKIIDERDSVIQIYEKKLVENTDHLSAVYEESIARYIEMHKKDKEEAIQRIRKEYEERIAEMQVITISSSDEEDDSPKKSNSKSQKELKDRILHYQNLVGEMSDELREKREALKDMENLLEEAKEHSACLELDIESYREKYNKEKSDTVMLREQIELLTLELQKRSAGVASEESSDIDDNEFENHEQETNSFVIAPKIEPKYSHPTEFLTLEIQKRSIGVASEASSDIDDNDIENHEQESNGKCELINTTHCVNVTSGEHKNSSGEFNVINTAHSLNITSGGHKNNNGVNEDSNTTYCANATSGKHQNGNGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K885</accession>
    <name>A0ABM5K885_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506400.1">
        <property type="nucleotide sequence ID" value="XM_050650443.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650443.1">
        <property type="protein sequence ID" value="XP_050506400.1"/>
        <property type="gene ID" value="LOC126884503"/>
    </dbReference>
    <dbReference type="GeneID" id="126884503"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="179"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="45261" checksum="7363F342BDB02052" modified="2025-10-08" version="1">MDQDDEIAAAAAAYIVLSAKKKKRKHKCWVKPSLCDRSEYGGMHLLNVLKKDDVYIGNNKNNGSVKNFLRMSSTDFEWLLCQIAPKIQKEDTNYRQAISPMERLLLTLRFLATGDSYHSLMYLFKISVSSISRIIPEVCKVIAEVLKDKLKMPQSREEWLITGHQFANLWNFPKCAGVMDGKHIMIQAPKHSGSEFYNYKSFFSVVLFIVANANYEVKYLNVGSQGRISDGGVFDSTHFKKMLYQNTLNLPELEPLPGRTKAVPFVFLGDDAFPLSPNLLKPYPGTQEKGSSKRIFNYRLSRARRISENVFGIMSARFRVLRKPMLLEPDRVELVVAACVYLHNFLRSSLHSRKSYSPPGTFDSEDKDTGERIPDPRFLEKRNKQQYVCITAKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAZ7</accession>
    <name>A0ABM5KAZ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UBR4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507364.1">
        <property type="nucleotide sequence ID" value="XM_050651407.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651407.1">
        <property type="protein sequence ID" value="XP_050507364.1"/>
        <property type="gene ID" value="LOC114328390"/>
    </dbReference>
    <dbReference type="GeneID" id="114328390"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19680">
        <property type="entry name" value="UBR-box_UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025704">
        <property type="entry name" value="E3_Ub_ligase_UBR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045841">
        <property type="entry name" value="E3_UBR4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056530">
        <property type="entry name" value="UBR4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047509">
        <property type="entry name" value="UBR4-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13764">
        <property type="entry name" value="E3_UbLigase_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19423">
        <property type="entry name" value="E3_UBR4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24079">
        <property type="entry name" value="UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52043">
        <property type="entry name" value="UBR4_E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="9">
        <location>
            <begin position="1680"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="6">
        <location>
            <begin position="1680"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1756"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2448"/>
            <end position="2483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2749"/>
            <end position="2780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2875"/>
            <end position="2943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3352"/>
            <end position="3376"/>
        </location>
    </feature>
    <feature type="region of interest" description="UBR4 E3 catalytic module" evidence="7">
        <location>
            <begin position="4714"/>
            <end position="5181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1758"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2465"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2875"/>
            <end position="2894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2903"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3355"/>
            <end position="3373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="5182" mass="577920" checksum="F12652631C1C6AE3" modified="2025-10-08" version="1">[encoded data, 5182 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD58</accession>
    <name>A0ABM5KD58_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane and TPR repeat-containing protein CG4341-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508110.1">
        <property type="nucleotide sequence ID" value="XM_050652153.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652153.1">
        <property type="protein sequence ID" value="XP_050508110.1"/>
        <property type="gene ID" value="LOC114326216"/>
    </dbReference>
    <dbReference type="GeneID" id="114326216"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052384">
        <property type="entry name" value="TMTC_O-mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44216:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33598" checksum="AABEA9932C591702" modified="2025-10-08" version="1">MKMGILLQGKNKLDEAILSYQRAIHFRPSLALAYVNLGAALIASGRCQEATAVLRQGSKLDGTGLKDRKEHESAKVSALLQLGALYSDQGRLQRALATYREAAHSLPDHYPPQSVFNVLGETLARLEQDEEAERWYIAALHAQPDHVPAHITYGKLLAKNISRVAEAEQWFKKAQRIAPEDPSVFHHYGEFLASRRRYKEAANMYEKAAELRPEDYELAVAAATAMRQAVRYQDAERWYRKAVSIKPTDARSHTNLGAILHLNGKYREAADSYRESLRLQPNDVTTLTNLHKLHTVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEH0</accession>
    <name>A0ABM5KEH0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508597.1">
        <property type="nucleotide sequence ID" value="XM_050652640.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652640.1">
        <property type="protein sequence ID" value="XP_050508597.1"/>
        <property type="gene ID" value="LOC126885868"/>
    </dbReference>
    <dbReference type="GeneID" id="126885868"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057946">
        <property type="entry name" value="TPR_ZFYVE26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028730">
        <property type="entry name" value="ZFYVE26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25569">
        <property type="entry name" value="TPR_ZFYVE26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2037" mass="235577" checksum="AB46AC6C965E7D37" modified="2025-10-08" version="1">MEEISKLIEKITRQDSTNQNKHINLLYKKISEFKPQDKHDTGCLFEYILPKIYDLFQRDIVKRDVLYLSLIGAHNVDVLQIFLKYHEATLNASLENATRLYDYCVCKKKHWFNEILTTDNLFITNQKILNKILTLQLIGITNSSKFDTQHVKRLLENIDQGDIQPFWKKYFVVTEYFLNIMDYVKSNISSLNAHDVFCHINENAALETFSNYLPLKSSSLEQALQLVVQEENIFEIKNHHSTQFEAFIILRNLFNCITRIPNINITDEVSDIKERLLKIPDLSLQLELLENIFVTIFLERSHLSNKVNESKMVCEEKEVRLLLFLVKEVLDEVKLNNTPAKESVEYAKLSQLNKVVADTIWRMELIGDIKGSSKCEKNLLKYMLSSPESLIQMCLARSDFERAFQVIKIFSLEEPYLTSEIKFSENLISLRDTLKKTIKIKAIQKVNPKISITTLNVCVDKTIEIFFKKNSIVTNPKIDTTIDKLSQKYKFFNHFHSKNEMFMNILDLAITVSQDNENSEIILQLACENNSLDANICSNYSKFCKRLVDLYKEIGKEKNLSLGEVIVLPEYHLDLNVYTKEEEFFATFAQAFNDAMSDLTLSEPGYLNMRHLSHRTVLKLNSLCVDNSYSRVMENKYILKLFNYLKAFSRVLYIEQNTSDIVSRGKNSSYFDLLVFNRSELMGKLLFERNLDPSEFEKYFEKLKLDYLYHVVGNCFPTINLHIEENVAKDELYPENNLYVPNKSIITYIQKRNWLLAYILNKMYMVEGVSIDISEIRVRVFMNYLGLRKVQVLQRVYNENTIITALQNEISIQKVSDYINDRILLHERSSNLHLSHNSSDSLEAAEELGEDTLGYINWKSVYDLVACIPEDQCRKNRVCLSMTDMVLVSLIQDGVEPDYYRYVLLIGNRDMRISMILDHIKEWPGDFCLDCIKSEITRFDGMQDGRIVELKIWLLHITLCETLKYKLDVTSWYAAYKMCENNKENVIAKLLEFADINLLLDFIDLHTPNEGLLELVNEHYLAKIFEQSTPFDRVKVLLDLLPFKHSVRMCYNAIKMLRDLKYLNFIVEYLLNNVSDESLRNVQISLKMLSIFSPFEQDQLLCLLYEPLSIIEILIMNTKLDKLASVLNIVKLEISQSEFDTAVISIKEIDELLRTYGEKTLDFRIITQPNPRLLRTPEFKLMQSLDSLNLGPYNKNFVMPDEVPIKDDWIPNNEVLECMCCQKIVFSMFNRRHHCRRCGRVICYNCSLHRMLVPTYDDILVRVCLDCYRQTVGESETSELNDSLSLKSAVYDFWILTDDDAHNTIVREEFSYEHAPNVSLCLSLMKYHSKTTEYPKFLLDQCSIMLKLLQPSQEPIQEIDYLLVIKMIKSLAMAAKMSSIECTLHYGTSLADRILSQADLLSLLAERGCLSLLPISNTYSQGPYIDASILRRLIDRLLQREQWNLALEVSTKAGIDNTGVFAVWGKSCLKAGSLQLAREKFQRYFDKTGHYSTDNLSEYSFSMQSESISESFSRSRNVSRASNLSPLPESKPIKNPSLLNEIIHILEANTISIDPEIGSKNGSLSGSMSSLNQSFILIQSESAICVLNKLKNLKNIASKHYYQPVQAELKSHSTKPPIHNIFYDECVYYLRRYGSHLGLLDFYIKHGDIQVALDYIIDNNLGTEVFIEIYMKCLKDGIVATLQEKISLIDSTLDLWKGYLRHICRHLEKHNMLHSLYQLQQFMGDSIRAAMTCIRFYQENALNFTDLVKNVSFLHKAEEHLKHGVEQEQWVEVATVPNHNSSSRTGFEEKGIINPSIVMKISTKEINKHIKTIERQSEIAEFLGKCEELGRKPLQIFVEMEKPMEDNSSTTTDEKPKIPTLFGSTQDKIYLAVLAIVIGKEVQDGFNIALRIIQDFSLKHVKIFCEAGKQMAKDERYSGIAELVNCIKQSCTNDEAVTDMCDEMLTLAVATFTKANVSGTKVEDLIKLIDNKTTKISAYIEVKQLKTAYFLAVKYKRMSDIRRILRQAELLNQPSIKALCQKVLQSHPHTPIHFTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEV2</accession>
    <name>A0ABM5KEV2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neuropeptide-like 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508727.1">
        <property type="nucleotide sequence ID" value="XM_050652770.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652770.1">
        <property type="protein sequence ID" value="XP_050508727.1"/>
        <property type="gene ID" value="LOC126885947"/>
    </dbReference>
    <dbReference type="GeneID" id="126885947"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045942319" description="Neuropeptide-like 3" evidence="2">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9575" checksum="AB306854D33A302E" modified="2025-10-08" version="1">MFKLVFIATLLALSVAGPAPEPKPAPVPEPKPAPKADPKAQFLAAPVVAAPAVAYSSAYVDAPLAYSSYVAAPVYSSAYSVYSPYAASYVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG36</accession>
    <name>A0ABM5KG36_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509166.1">
        <property type="nucleotide sequence ID" value="XM_050653209.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653209.1">
        <property type="protein sequence ID" value="XP_050509166.1"/>
        <property type="gene ID" value="LOC126886336"/>
    </dbReference>
    <dbReference type="GeneID" id="126886336"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF15">
        <property type="entry name" value="RE18252P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="383" mass="43292" checksum="F029F9AF07A916B8" modified="2025-10-08" version="1">MPFMWTHELVLELIENYKLCECLWNTKHAQYKCRNAKHDAWTTLAEKTGSNIEEVKRKMKNVIAQFYRERKKYRTLKKSGTGAVFISKWFAYEVLLFLAGRNKVRKCTEKGITTSEGEDDGSDSSATDSGEVESQDSNIADEADAVTDSSFIVGEANNDVDTLNKTVAAITETPTKPNENRTRSPTPSTSSTTKSKQGPRLFKSPKTMKKRQADVTTDERQEEAYVLLKQLQNKKPRNRFQIFGELVACKIENLQNENAKNTVEHLISNILYDASMGKYDRPFPCYQSWHTPSANNNTARYYSDNQNYYSSSTNDSVTSPASTTHTPMPSPNSSCYETNYLPQTETNNSTLSKEKQPCRNLQESSISDAIRLAMSDAGLDVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHU7</accession>
    <name>A0ABM5KHU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509698.1">
        <property type="nucleotide sequence ID" value="XM_050653741.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653741.1">
        <property type="protein sequence ID" value="XP_050509698.1"/>
        <property type="gene ID" value="LOC126886728"/>
    </dbReference>
    <dbReference type="GeneID" id="126886728"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13668" checksum="D00F5EC7E1E6FBFE" modified="2025-10-08" version="1">MIIIAGVTKFERFRNEDIWRELEQEPTMRKIETKQLNWFGHIERMEKRTLTKKVHGAKMGKKSRKERPRKTWMDQIHDIGEKRDMTKRDIKNLATNRSAWKKWIRGGTLHPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHX7</accession>
    <name>A0ABM5KHX7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050509817.1">
        <property type="nucleotide sequence ID" value="XM_050653860.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653860.1">
        <property type="protein sequence ID" value="XP_050509817.1"/>
        <property type="gene ID" value="LOC126886796"/>
    </dbReference>
    <dbReference type="GeneID" id="126886796"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="211" mass="23866" checksum="F38621014BF5DC59" modified="2025-10-08" version="1">MAHTYKLIYFDVPGKGEAIRMILSYGEIPFEDKRIQMGDWPKLKPTTPLGQLPLLEVDGKAIPQSTAICRYLASIVKLDGKDAKENLALDVALETLFDLQKMNGEIKYEQDAAKKKEKLEKLLQQGLPLYFGKLDEYAKKHNGYIAFERLSWADILFVCVYEALVNLAGKEAVASYPSLQQVKKNVLATKGINKWIKNRPAVEGYDLKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIT9</accession>
    <name>A0ABM5KIT9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510131.1">
        <property type="nucleotide sequence ID" value="XM_050654174.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654174.1">
        <property type="protein sequence ID" value="XP_050510131.1"/>
        <property type="gene ID" value="LOC126886968"/>
    </dbReference>
    <dbReference type="GeneID" id="126886968"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17515" checksum="A842EFE686B0A08E" modified="2025-10-08" version="1">MYADDVVLVGNSERDLEQKLEQWRQALEEKGLKLSRTKTEYLECSFKDGATTNKMVSLDGEMIVKSNSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVAEMRMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMG0</accession>
    <name>A0ABM5KMG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">B-box type zinc finger protein ncl-1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511374.1">
        <property type="nucleotide sequence ID" value="XM_050655417.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511375.1">
        <property type="nucleotide sequence ID" value="XM_050655418.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655417.1">
        <property type="protein sequence ID" value="XP_050511374.1"/>
        <property type="gene ID" value="LOC114327693"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655418.1">
        <property type="protein sequence ID" value="XP_050511375.1"/>
        <property type="gene ID" value="LOC114327693"/>
    </dbReference>
    <dbReference type="GeneID" id="114327693"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="96615" checksum="BEF73A4FCF0F959C" modified="2025-10-08" version="1">MGTNTKDDFSESKEYGVKSEEFEDFSETMLDGSDKKSLEDGSLSDPDNCGMCGGPLVIPRMLHCLHTFCEECLGKKLVGEAGDAGSTDTSIQCPICNYSTLVGTKKLAALPLDVSKTNVTDVSNSPDLHCTSCTAKEMAKSKCNTCQHLLCNNCDKAHHFMRCFESHKVVALEDMVKSGIKITVHKPLVCDFHPGENLIFYCLVCSVTACTECIKVDHKGHQFEGILDSEPRVRQEMEGLVKKGKEKIENLTKASATLNNNMEELSHQRSTARDLINESYQSYKAVLEKCKDDILEELTGLYHERELVLMQESNELGNTIVNLEDACKCTSSLLEGGTAQEMMYLRTALATRLMTLNHKSPKLEKSFSIEFKSDLDKFEYAIRSNFGKFATEEDVIVKTSQSSPVLPELAPLNINGINGINNSPPAIVTNGCSAPSVTTTSPISLPTSMQSSFDGELGNNLQMLMAQSPPLPHVNSNQGFSQGFSSIAEYNIAQLATLAENTNSAATSPTTAPFNIADILNNDTAFKNIATLVKLAENVPNGNNMLARSTSAASLNLSNNLINGFGGVSTSTSPLLSTPDDIIPDPLTNIIPNTGTNTTPSIPRSNKVSPMQIRCKFGQLGPGKGQFNSPHGFCLGLEEDIIVADTNNHRIQIFEKTGTFKFQFGIPGKDEGQLWYPRKVAVMRNTGKYVVCDRGNERSRMQIFTKNGHFLKKIAIRYIDIVAGLAVTVNGEIVAVDSVSPTVFIIGESGDLLRWFDCSDYMREPSDIAIHGKEFYVCDFKGHNVVVFNDDGQFLRRIGCENLTNFPNGIDISDAGDVLIGDSHGNRFHVAVFSRDGGLISEFECPYVKVSRCCGLKITSEGYVVTLAKNNHHVLVLNTLYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRH6</accession>
    <name>A0ABM5KRH6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512788.1">
        <property type="nucleotide sequence ID" value="XM_050656831.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656831.1">
        <property type="protein sequence ID" value="XP_050512788.1"/>
        <property type="gene ID" value="LOC126888494"/>
    </dbReference>
    <dbReference type="GeneID" id="126888494"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21623" checksum="DD823D875B0E24AE" modified="2025-10-08" version="1">MDETYVHSSHTYQKSWSDSSNKGIQKPVSKGQMLVIVHAGGENGFVKNTYLRYKPTIKTGDYHDAMNYDNYKKWLQDKLIPNLPPNSVLVIVNAPYHNVQIEKCPTMSSRKVEMQQWLTTRNIPFTDDKLKFELYDIIKLHKPLFKTYGIDKILEDKGHSVLRLPKILSGFESYRVSMGFYEAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRL7</accession>
    <name>A0ABM5KRL7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512835.1">
        <property type="nucleotide sequence ID" value="XM_050656878.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656878.1">
        <property type="protein sequence ID" value="XP_050512835.1"/>
        <property type="gene ID" value="LOC126888533"/>
    </dbReference>
    <dbReference type="GeneID" id="126888533"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="256" mass="30116" checksum="FCF2A62238F0D22F" modified="2025-10-08" version="1">METKQLLQVDRELIRKKWGKTEGDVMKDILIIREWLKTQKHLPEVPSNNMIEFFLTNCKFSIEKTKKNLDMYYTIQTLLPELYQNCNPCAPEMDRVHDIVSFLCIPTLTPTLHRLTVIQYHDVDANDNDMKGILSLFLRVFHEIRMHEDLAMGEIYILDLERIKFSVISRLTPLLFKKVGFVFEKIHSSRMHALYFYKAPTLFHNALILFKSLLSKKLSDRVHSYQSMDEITKHIPIELLPCDYGGQQKSIKELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRS7</accession>
    <name>A0ABM5KRS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512891.1">
        <property type="nucleotide sequence ID" value="XM_050656934.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656934.1">
        <property type="protein sequence ID" value="XP_050512891.1"/>
        <property type="gene ID" value="LOC126888584"/>
    </dbReference>
    <dbReference type="GeneID" id="126888584"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="186"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="603" mass="69008" checksum="7AD31ED27707CEC3" modified="2025-10-08" version="1">MFRKGLSEDELRRLAEESDFSDSSMSESTFYDSDADPVYNENVTDGSSDSYSSEYESRRKKAKICKQTQNCKEFTAGSSSNQKEADTRRIEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVVSRNKITWSDVPNPDDLNKFELSFTSGINQEELAKLTDHKPIDFYLLFIDRQVQDLLVTETNKYAEQTIIAGIVNESITKHSLMSNWRPIDRKELLRFLALIIWMGLDRKPKLRNYWSNNLLYKNEVSKMCEISRSRFEILLHFFHISDNESCPPGNRLYKISPLVQILNEKFQKMCTPRESLCIDETMVPFRGRLSFLQYIPGKRHKYGVKLFKLCVADGYTYAVKVYGGKEMQPSEKSLASRVVMELMQPLLDTGRSLYTDNFYTSVDLAHDLNNRKTHLVGTLRSNRKHNPKAVVNAKLKRGDMKYLQSNTKVVIGKWKDKRDVLFLTTNDIPLMIDVQTKRGPVPKPSTIVDYNSAKSFIDVSDQKAAYNSPVRRSMKWYRKLAVELLTNTALVNSLVLYKSVTGKHLSITEFREQIVQSLLMPQTTSENSLTTSENSLTTLHTLDEKEKRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRU6</accession>
    <name>A0ABM5KRU6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Envelope fusion protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512912.1">
        <property type="nucleotide sequence ID" value="XM_050656955.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656955.1">
        <property type="protein sequence ID" value="XP_050512912.1"/>
        <property type="gene ID" value="LOC126888600"/>
    </dbReference>
    <dbReference type="GeneID" id="126888600"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022048">
        <property type="entry name" value="Envelope_fusion-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12259">
        <property type="entry name" value="Baculo_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41992" checksum="FEA30C818231DD7B" modified="2025-10-08" version="1">MEALKEISQSLQNNVLPLPTYMSNIAQYIDIIKLQAYQLDSKIVFVLEIPLVDPEIFTLYQLYSIPILDNQTGFHHILSTVHKYIARDDDSISYVLPMDTEKCNQISQNQRMCTDILPYPIDTDAICEAQLLKPLSNLPKSCQMSMLLAQGYNVQEIDRNLWLLTISDPLPVTIKCARKDVTTRIIKTNSILRLIPECIAFIGSTRIHAKDQIEKYTNITYRSHPVNVPYRCCDHFETKSHLSKLKPLKLSKINVDDLNIAQHKLDQYSEEVDHIMSQSFIEEHLPLFTISTLSLIINLVILYLCCKYRTKIFPKIAISLSQDQPPTSAARRNSIRQKLQSLTSFRRRPNVQQESEEEAETPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT15</accession>
    <name>A0ABM5KT15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction. Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WRNexo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513332.1">
        <property type="nucleotide sequence ID" value="XM_050657375.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657375.1">
        <property type="protein sequence ID" value="XP_050513332.1"/>
        <property type="gene ID" value="LOC126889262"/>
    </dbReference>
    <dbReference type="GeneID" id="126889262"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="73"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="252" mass="29325" checksum="88224F14B987051D" modified="2025-10-08" version="1">MNLRRSRRRSPEAEEKVEAKIMKLEMTLRPRPSPEEKAEAKRIAEYRANNPFIEFKGKITYHTELIDIALVSDNLLERAKVVSDLLIIGFDMEWPFNFQTGPGKTATIQISYDEEHCYIFHVSKIRNLPSSLSQLLIHPNVRLTGNCIKRDVRKLARDFAGFDGDKMVDNCVDLGLFANRVLSIRDRWSLERLVEHFLDLQISKDKKVRHSRWHIIPLSKEQQLYAATDSYASLLLYNVLKSRENDLKALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT64</accession>
    <name>A0ABM5KT64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sarcospan</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513383.1">
        <property type="nucleotide sequence ID" value="XM_050657426.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657426.1">
        <property type="protein sequence ID" value="XP_050513383.1"/>
        <property type="gene ID" value="LOC126889295"/>
    </dbReference>
    <dbReference type="GeneID" id="126889295"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030429">
        <property type="entry name" value="Sarcospan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15260">
        <property type="entry name" value="SARCOSPAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15260:SF1">
        <property type="entry name" value="SARCOSPAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34409" checksum="EC6168E7ECF0A4DD" modified="2025-10-08" version="1">MDNSSSNYQSPYIEIEMKDVQTRPVSFYENTKPDQLSSSNNNVSQGECPNRSQINFLNTTVPVNILAQDIAGKHTPSRNSLRHSRMIVLHKSGEAPPVIPSALQYYKIVRLLLIAILIVGLAMCILSLWLLLWTPNLRSRDNPGWSGIPVLVSSFAGILFISTIPNPKGYSGRKFRYWRKGLKWTSVTISAVAACTSFLTFVFSVLHLIVLSSMICAPPDKLVSTCLCNVNTTKLSILTDSYHYVDLSCFEVETALKILIIFSAIASCSVFLFELVYLYLHWVNRNIHEYSRVPINALQIHREHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXK6</accession>
    <name>A0ABM5KXK6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514928.1">
        <property type="nucleotide sequence ID" value="XM_050658971.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658971.1">
        <property type="protein sequence ID" value="XP_050514928.1"/>
        <property type="gene ID" value="LOC126890124"/>
    </dbReference>
    <dbReference type="GeneID" id="126890124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="249" mass="28810" checksum="0F094B0AE55F468E" modified="2025-10-08" version="1">MEGLSRRRGSQKAKVTIFSKYISPLHDRIKKGESISELEVLQTVEMLSGIENLVEFNEIQDQIETLVKADQLATEVLEGEEFYNKHSSVVAIARKIIRDYGGDKASEHSKNSYAGHCIKLKPIELGHFNGNMENWLDYANIFESLVNKNEYLDNIRRFYYLRSSLQGSAAQIIRTLEFTAENYEIAWKLVRERYDNNRLLISNHVNALFNIEPINKESSGRLRQLVDIFSKHLYALKQLGLPTEYWAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY60</accession>
    <name>A0ABM5KY60_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515129.1">
        <property type="nucleotide sequence ID" value="XM_050659172.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659172.1">
        <property type="protein sequence ID" value="XP_050515129.1"/>
        <property type="gene ID" value="LOC126890312"/>
    </dbReference>
    <dbReference type="GeneID" id="126890312"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052818">
        <property type="entry name" value="NEDD1_Spindle_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414:SF1">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="424" mass="47046" checksum="C36127CEA5D073FE" modified="2025-10-08" version="1">MKFHPNLPNILGLAFGNGIVTLKDIQTGENMISLEKHSAPITGINFTANQKTVITTGLDKKICIYDFVSGECVFCMNIHQSVTSSDISLDDICIAAGLDDRCISLYDISSGGSSILKKLGELDSPIRTVDFNSVDEQLAISPDKSLNLFTDRDSENNFVKTANYSEKCSYMKFHPNLPNILGLAFGNGIVTLKDIQTGENMISLEKHSAPITGINFTANQKTVITTGLDKKICIYDFVSGECVFCMNIHQSVTSSDISLDDICIAAGLDDGCISLYDIRDPLKPFMYTNAHNCPVNKVSFEKSPVFIEHLRDRNSETTLMDSDFGDQSYAVQDLYEAENDPEEKFKQDIMKMIKTNMDNLQAQLNEHCTKFQNFMISEFDSIQNAMNRWDVFNMGDNTEIVQALNSVGSKSVKIAYSKKSNGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ24</accession>
    <name>A0ABM5KZ24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050515440.1">
        <property type="nucleotide sequence ID" value="XM_050659483.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659483.1">
        <property type="protein sequence ID" value="XP_050515440.1"/>
        <property type="gene ID" value="LOC126890500"/>
    </dbReference>
    <dbReference type="GeneID" id="126890500"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045002669" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="25"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="542" mass="60281" checksum="77932C8A2358C51D" modified="2025-10-08" version="1">MFVKHILFVVNFLALMFLEVSSDNVQVTTNEGTILGKTSLSEKNHKMYMFHGIPYAEPPKRFELSVAKSNWTGVLDCTRERAQCVQGRGIIVQGSEDCLFLNVASPNLNGTAPVMVFIHGGTFKNGTGSLITNSPELFLEEGLVVVGIEYRVGVFGFLSTGDLTCPGNWGLKDQTLALQWVQRNIANFGGDPKRVTIWGQSAGAVSVSLHLTSKRSKGLFRGAIMNSGVSLCLWGLSRTGNELAHNIGTKLGVGSANSSQLIENLKKVDYVSIQSVSDLLSVEAFNNYPLTGIALGPVLEVPHPTAFLTVKSDNSILSGQFTRVPVLVGYNTNEVGIMAPLAFSGSVPTLQSEPKKFVPVDIISDKNLTEAGLKIRKEFFGNAPYITMDSNLINFINIDVFVKPIHRFVFDVKKYVPDTYLYQFSYKGDLIRTLTFLFNIKGTVHGEDMYYLFKSNFPFSQKDLKIRSKMVKMWSNFCKYSKPIPQPTSDLDNVDWLPATQCPILFNIGEKNENIVNPHLRQLQFFDNEIYNKYGQGVYDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZY0</accession>
    <name>A0ABM5KZY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515744.1">
        <property type="nucleotide sequence ID" value="XM_050659787.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659787.1">
        <property type="protein sequence ID" value="XP_050515744.1"/>
        <property type="gene ID" value="LOC126890666"/>
    </dbReference>
    <dbReference type="GeneID" id="126890666"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF87">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="223"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="348" mass="39586" checksum="548103514E6F0A81" modified="2025-10-08" version="1">MEEYYQGSSRSRGSSSVSDNDPRAKIKDCCRKVIAFMCTQVGLGALVFGYTLVGAVSFMTLEQKGVNIEPVQINEKREEYLVKLYKVALKHNIFDVDSFFSDSDAVLKSYQEKVVEIFKYGYSERSVNDMWTFSAALMYSLSVITMIGYGNLVPRTSYGKIATVVYALFGIPLYVLFFLNVGDALAGSFRWIYRKMYKCSTQPEETEEIPKRIIVPSSACIWVMIIYVIAGAAIFSAWEGWGFLDSVYFCVTSLCKIGMGDFVPGMDDFVPGTSTVDNEAEGHSKLVLSYIYIFFGLGLVAMCYNLMREEIREKVKNIREDFTQCVEDTRLRILECCKKMRGEQEEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L057</accession>
    <name>A0ABM5L057_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515824.1">
        <property type="nucleotide sequence ID" value="XM_050659867.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659867.1">
        <property type="protein sequence ID" value="XP_050515824.1"/>
        <property type="gene ID" value="LOC126890705"/>
    </dbReference>
    <dbReference type="GeneID" id="126890705"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="474"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="729" mass="85810" checksum="575F192A9A07D1D1" modified="2025-10-08" version="1">MGYCFTDEQENVRIYCSDKETVLENCNKRCTNADNYLEGIIPMQKTFPSEQHARDESEMSYASSVAASLPDEIQDLLDFSSDDSIADPNFVPAQDEKYDSFAADSDIVERKKRRANSEEDINNTAVDKYNLDGQVHEKVKKRTNKETRKMRQERREKRNFGKAYVTRTGKEIKEKTMQELKLCRNKCKEKIKDEVRLQLFKEFWEMGSYNRRLEYIAALMDVKEKSSMRIRCSDPSKQRYRQHTIIYHFPLHGVRSVACKDCFMKTYNISKKFIEVIVAKKCSQISGVMTLDQRGYHENRKKVSDDEKIRARDHILSIPLYESHYTRRQSSRKYLPSNYTLTAIYEAYKKIYPDNFINRKMYENIFHSLNITIKKPKKDTCGKCDKLKMKITMCKNEDEIKLLKEELNEHHLQADQGYKNKEDDKFLTKDNAKMKTITFDLQQCLPIPDLHSSESFYKRQLWTFNLTVHDCDNSQAHCYLWHESLAKRGGNEISSCLYQYLTKDLDPKVEHVIMYSDCCPGQNKNRFITAACLTALQCSANLKIIEHKFLIPGHTHMECDTDHSLIEKKKKKFSSQIEHPHDWAQLIRQVGSKRQFLVTEMQRSAFLNFGGLFNSVLVNRKTDTQNNKINWRQYRWLRYEKSNQFQYKLSFDKEEPFKTVDLEKRGKAAINLLPKEAYNKPVPITIEKKKHLMDLLPYISESLWDFYKNLPTDKDLADVLPDSSTSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0A2</accession>
    <name>A0ABM5L0A2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515867.1">
        <property type="nucleotide sequence ID" value="XM_050659910.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659910.1">
        <property type="protein sequence ID" value="XP_050515867.1"/>
        <property type="gene ID" value="LOC126890739"/>
    </dbReference>
    <dbReference type="GeneID" id="126890739"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="528" mass="59454" checksum="D1CD6B41E90A7B8A" modified="2025-10-08" version="1">MDLDDILPSVGEFGKYQKLVIWFILLPAVFPCGFHAYNQLFMATVPRHWCNISYLLNNTKSLGLGNISQYSDNLENCYIKNHTQSIPCEDGWKYKDEIKNSVVSEWNLICEKDFLVTLALVLFGTSGLIGNYIFGYVQDGFGRKPAYYIYLLIGCIFGVATAFAHNYVMWVIFRIGVGFTVPAILGTPYVLAIELVGPSDRTLVTILINIAYSVSLISLAIIVWAVRQWRVMALATTLPFLALFFSWPLLPESPRWLLAQGNYEKAETILQNMARVNKKQVPKDLIANFRTQRTHQKINFKSKIRYGIKDLFRSKNLRWKTIIITFLWFTNTSVYVGLSYYAPTLGGDEYLNFFLAGAVELPTYLFLWPAMERLGRRWTLCISMIIGGTSCLATFLVQNDYVTTLALYCVGKMGISSSFVVLPLMASELYPTVVRGLGMSLSSVIGMLGPIFIPLVNYLGSDILILPLIIMGTMLIMGGTSSLLLPETLNQHLPQTLQDAEITPLDCFAFCNVPQKSEKHVSVFESKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1V5</accession>
    <name>A0ABM5L1V5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516418.1">
        <property type="nucleotide sequence ID" value="XM_050660461.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660461.1">
        <property type="protein sequence ID" value="XP_050516418.1"/>
        <property type="gene ID" value="LOC126891282"/>
    </dbReference>
    <dbReference type="GeneID" id="126891282"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="275" mass="30700" checksum="97E38B2604711AA9" modified="2025-10-08" version="1">MSADQFNELLRTVAASPGTNNSSGSFSKCTARFSGKRCHNTVETFITTVSIYKEIEKISEADALKGLPLLLTDNAAVWWQGVQNEAKTWNDATQLLRTAFSPSKPAHQKRALLAQLPLNRQDEQTQLDLIYGLLSLHIRKEVPRDKITTFSELLDKGRQCEEIRKEAIPDKGIDEKQGTSTKRKPARCGFCHFKGHTTDVCRKRQTKENEKHPGTDKAPDTQNSLKELPQTNNGIICYGCGKAGYYRSNCPVCTASRPNVNTQAVNFTPSIHYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2B1</accession>
    <name>A0ABM5L2B1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516581.1">
        <property type="nucleotide sequence ID" value="XM_050660624.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660624.1">
        <property type="protein sequence ID" value="XP_050516581.1"/>
        <property type="gene ID" value="LOC126891448"/>
    </dbReference>
    <dbReference type="GeneID" id="126891448"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="572" mass="66124" checksum="9AA36A7FC34A8AFA" modified="2025-10-08" version="1">MLPCIHCKGYYAKKSLRRHIRRCYFNEKKATGKVRHQSEAQNLMATNFGSTDPLRTSGVLNSLAADDISLVAKKDKLICDVGRKYVKSHKDRHLIQVAKRQMRRLARLLIQSRKIENNSNLTLFFLLHPSKFKTIVSATRSIANYNNESKCFQSPSLALQMGTLIKKAISSAYSVEVQRDVDSANIKSLDVMKKLIDDQWALEISTEAGQNIQINRFNKPTLIPMAEDIAKMKTYLDELITSSITHLDENVNNTQAYKCLLEGTYCSLLLFNKRRVGELQRLPLDIYLKHHDSQSSKEFEKVLTETEKILVHSLKRIVIRGKRGRGVPVLFDKLTKSGVDTLIKYRNNFFTSYNEYLFGIPNTINCISGYHVLRKHASKVLNDANKITTLTSTPLRKHLATIIQILKMEKGELEQLAKFMGHTSKTHDEWYRLPSDIYQTAKVSKILLLAQNTNIDQYKNRNLNEIEVDNEILEDAEEADSDEENTNQPILQQNEVNIPSQNRIKEKGKRILVPWTKEEKELTQKFFARHIKKKIPPKKMEVLNLVEKYPNVFKNRKWDTIKVFVQNKYKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2J8</accession>
    <name>A0ABM5L2J8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050516666.1">
        <property type="nucleotide sequence ID" value="XM_050660709.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660709.1">
        <property type="protein sequence ID" value="XP_050516666.1"/>
        <property type="gene ID" value="LOC126891533"/>
    </dbReference>
    <dbReference type="GeneID" id="126891533"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="189" mass="21371" checksum="48DF940BCF68A352" modified="2025-10-08" version="1">MTVCFADFQNVRLILDCTEIYVQTPKCLCCRIRFYSQYKSHLTIKFMTGVSPGGLITYVSKAYGGRASDKVIFEESNVIALLDSSRDAVMVDKGFLIDDSCRLYNIQLIRPPFLRKKSQLTTEEAILNAKIASARVHIERINQRLKIFKILSGKLSWAYVPLVDDIFTIICAITNISSPILSDGKFLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L368</accession>
    <name>A0ABM5L368_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140094.2">
        <property type="nucleotide sequence ID" value="XM_028284293.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516896.1">
        <property type="nucleotide sequence ID" value="XM_050660939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516897.1">
        <property type="nucleotide sequence ID" value="XM_050660940.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284293.2">
        <property type="protein sequence ID" value="XP_028140094.2"/>
        <property type="gene ID" value="LOC114334257"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660939.1">
        <property type="protein sequence ID" value="XP_050516896.1"/>
        <property type="gene ID" value="LOC114334257"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660940.1">
        <property type="protein sequence ID" value="XP_050516897.1"/>
        <property type="gene ID" value="LOC114334257"/>
    </dbReference>
    <dbReference type="GeneID" id="114334257"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="154" mass="15722" checksum="F5D5358F0F1FA1A4" modified="2025-10-08" version="1">MEGFIIFLIVATVIGVSALFIKTCIKCFSVKKPRQSQNNNFVSDNYDYEDGVIFTSELYGTDYNVDSVNEVTHIHHFETSDNIDTTPGDTDNTGSGVASGLAGGFAETFTSSFADPGGSSTYDSGGGGFDSGGGGDTGGGGDTGGGGDTGGSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3D1</accession>
    <name>A0ABM5L3D1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516951.1">
        <property type="nucleotide sequence ID" value="XM_050660994.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516952.1">
        <property type="nucleotide sequence ID" value="XM_050660995.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516954.1">
        <property type="nucleotide sequence ID" value="XM_050660997.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516956.1">
        <property type="nucleotide sequence ID" value="XM_050660999.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660994.1">
        <property type="protein sequence ID" value="XP_050516951.1"/>
        <property type="gene ID" value="LOC126891728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660995.1">
        <property type="protein sequence ID" value="XP_050516952.1"/>
        <property type="gene ID" value="LOC126891728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660997.1">
        <property type="protein sequence ID" value="XP_050516954.1"/>
        <property type="gene ID" value="LOC126891728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660999.1">
        <property type="protein sequence ID" value="XP_050516956.1"/>
        <property type="gene ID" value="LOC126891728"/>
    </dbReference>
    <dbReference type="GeneID" id="126891728"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028550" evidence="3">
        <location>
            <begin position="25"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="189"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="636"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="993" mass="112677" checksum="E5EE56097B1781FB" modified="2025-10-08" version="1">MVVKGVVLCLWFVFLGITTATLESFPNTTRSTIRKRRQSSLECTLPPQLENGRWLVTEADVKPGDKVDFNSIIRLECHEGYQLYPDIRLQICDSYWNENNLPTCKKRCPPFYSTATTTLTCKDINNEAVPCDKAVNGTYLTYNCNDYHEIPPGGSNILYCDDGVWDFQKPICQPICGKKVKVGEATALLWGGRQANDYEFPWVIAVFKISGTGFENICGGTLISRKVVITAAHCVTDTYGNALDQNKFQVAAGKVYNAFGDKRDVHAQYRKISKVIVNDGYRGETQKYIADVALLITQELFKLDPIVQPICMDNMNSVHLTNYQIGEVAGWGLTEEEEPSEILKAIRIPYKDSATCAKELPPSWEEVYNIFDKICAGRQNENIAVCKGDSGSGLVFKNREDNRYYLQGIVSIAPTLQNSQCNYQTNALYTSVQFYYSFITREMSKYFIEDCILPPYPKNGKWFLEGGVEKKPGDIVLSSTILRFSCNTRYILSTISAYNDCQSYYSHPTCLRICPKPLLPSGTQMLCKNSKNQYIDCTDIADGSSITFTCPNGFVSDRGTSTSTRFCRNGVYGNSAPSCIDIKQKPVHVSNTSDKSKKTTKHTTATTATTTSMITTPNPSITLEKSVTSQIINDGKKVICYYSGWTAYNGSYPEEVEPRLCTHIVYEYIGIHQNGELDLEGKGPDLHKLTMDLKNKNKDLKVMISVGGSRISYTLLRTLFTDSERKESFLYSTVEMIQAYSFDGLDVSWMFPKPSDKDRYISLLDQIKRIFKHYGWLLSVTVYPKLEDTGYDPLKMDSIVDWVTIKTLDVYNTLFFKVKDIQLYTGYDWKKEDLNLNRETVIRNWLDAGLSKNKLIMGIELYPIKFTYMNANNTKEKPKVVIHGYDEKRCPDYRLLQINWAIKRDNNTENDYVYGHHLNVWVGWNDADYIFSKGRYAKDKRLGGLAVFNIEQDDYKGVCGAKLVLLKGLLNGFGFSDSSFIRKKTYLNKFIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L489</accession>
    <name>A0ABM5L489_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517254.1">
        <property type="nucleotide sequence ID" value="XM_050661297.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661297.1">
        <property type="protein sequence ID" value="XP_050517254.1"/>
        <property type="gene ID" value="LOC126891950"/>
    </dbReference>
    <dbReference type="GeneID" id="126891950"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="585" mass="69211" checksum="120B015B4A0369F2" modified="2025-10-08" version="1">MELSEDSIKIKQDVLICDTDGDSLEQHVNVQTKSELEEYMLESNYTENSLSDSYCSEDIKIEEHTLQYDISNPFPVITKQEVMTEIKKELDEHNLEVNHECDKNTNRKKLEAERDVKLEIGASNEIDHDSHCGSMETEKLLSNIDKKNLCPKSERSLVTHTRENSYKCETCLEEFALLQNLKSHLRLHVGEKPYKCKTCLKEFSQNEHLKKHLRLHTGEKHYKCETCLKEFSRDENLKRHLRVHTGEKPYQCQICFKQFGQDEHLKKHLRVHTGEKPYKCETCFKQFGQDEHLKKHLRVHSGEKPYKCESCFKQFSQAGSLKRHLRIHSGEKPYKCETCLKEFALLQNLKSHLRLHVGEKPYKCKTCLKEFSQNEHLKKHLRLHTGEKPYKCETCLKEFSLDENLKRHLRVHTGEKPYKCEICFQQFGQDEHLKKHLRVHTGEKPYKCETCFKQFGQDEHLKKHLRVHSGEKPYKCETCFKQFSRAETLSNHLKIHSGEKPYKCETCFKQFSRDEHLKKHLMVHTGEKPYKCEICFKQFSQDGHFKIHLRVHTGEKPYKCEICFKQFSHAGSLKRHLRVHTGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4F2</accession>
    <name>A0ABM5L4F2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517310.1">
        <property type="nucleotide sequence ID" value="XM_050661353.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661353.1">
        <property type="protein sequence ID" value="XP_050517310.1"/>
        <property type="gene ID" value="LOC126891979"/>
    </dbReference>
    <dbReference type="GeneID" id="126891979"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26523" checksum="00E90F593A940A37" modified="2025-10-08" version="1">MGEHHINVARIVGMVVDLAEPLLDLADLFPAERRDITRNENYYEETIPNYTNTQFQEHFRMSRETFEVLLQQVQQFVEVEGTRIPLRKKLLFALWTISKQDSFLAAGDRFGLAKSSGHGIFIEMVRVIGRMCQTYINWPNLEAQMRIANVFEHRSRGIPGIIGAIDGCHIQIKQPEGNAIDYYNRKGTHSVILQGEIEDQQENNVVENNEPILQGAEMKRRELVNLCNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4N2</accession>
    <name>A0ABM5L4N2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Farnesyl pyrophosphate synthase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517399.1">
        <property type="nucleotide sequence ID" value="XM_050661442.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661442.1">
        <property type="protein sequence ID" value="XP_050517399.1"/>
        <property type="gene ID" value="LOC126892028"/>
    </dbReference>
    <dbReference type="GeneID" id="126892028"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="45202" checksum="6A4322E33A26AEDB" modified="2025-10-08" version="1">MLKKIIEKSGFLKPLTVQSLVLRLQSESSQELAPERLPYSNRRRELDYSFEETALQAVVPQIKEEILDDQLEDHINVPHLRQRYSKLLDKTTFDLTNPYLSCGLASVHSYLQLEKFGNVTPGQLKLSCILGWCYRLQISSMIVYDDILDDQKVRYNAEPWHKQVGTKEAILDTLFLKSSASSLFRRYFESHPQFLNMLKMFNKCYGTCTIGQLLEIQTYDLEDFKTYDALVKCFPVTLYPVRTAMYLANIVDPKLHFAVEQFCRDLARFIKVEDDMWGAYEPITKTEKDCPDISAGRVTWLGQQVAKYGKPSQKRIFSENYGKNETTALRKIQNIYEDMQIYESYKKYEEKFYNEMCESIEKLPKELPRQLFVDLLDFALVKKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5M3</accession>
    <name>A0ABM5L5M3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517737.1">
        <property type="nucleotide sequence ID" value="XM_050661780.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661780.1">
        <property type="protein sequence ID" value="XP_050517737.1"/>
        <property type="gene ID" value="LOC126892266"/>
    </dbReference>
    <dbReference type="GeneID" id="126892266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19584" checksum="7D2F8F348D254431" modified="2025-10-08" version="1">MDDNIRAREIRKAEQAKEKEPQTGKNTQMDEDADEEKEGFTEVNRKKGNKRKNKEKTEKENPDKQVKSNSENQTKTNKDQNNEKTPDKGKAATASTSKTVETTQNKNNRKPPPIILKTIESGQDILNTSAKQGIITENKFAKSGRSIKIQSRNREDYHGMLKILENKGNQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L692</accession>
    <name>A0ABM5L692_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517955.1">
        <property type="nucleotide sequence ID" value="XM_050661998.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661998.1">
        <property type="protein sequence ID" value="XP_050517955.1"/>
        <property type="gene ID" value="LOC126892466"/>
    </dbReference>
    <dbReference type="GeneID" id="126892466"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="190" mass="22016" checksum="8F9307F3E9A8D1D2" modified="2025-10-08" version="1">MSGVPCTILVSIEDRLNFPTKMALVVIRQLFRYGLRSISLRNDRILIDLVYTPKSTTLSRKFGNLPVKYIRMQINDSNEIGLFEKAMKRYYFDLEEETEALPPPPPPTTTPSIKSIQKEPLKKKLKRRVTQHVESIDLDQNSQVWSFDEHIIDDDDDDKEDHTRRATISETRNDYGDDDDCTTTLIPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6E4</accession>
    <name>A0ABM5L6E4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518002.1">
        <property type="nucleotide sequence ID" value="XM_050662045.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518272.1">
        <property type="nucleotide sequence ID" value="XM_050662315.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518273.1">
        <property type="nucleotide sequence ID" value="XM_050662316.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662045.1">
        <property type="protein sequence ID" value="XP_050518002.1"/>
        <property type="gene ID" value="LOC126892501"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662315.1">
        <property type="protein sequence ID" value="XP_050518272.1"/>
        <property type="gene ID" value="LOC126892676"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662316.1">
        <property type="protein sequence ID" value="XP_050518273.1"/>
        <property type="gene ID" value="LOC126892676"/>
    </dbReference>
    <dbReference type="GeneID" id="126892501"/>
    <dbReference type="GeneID" id="126892676"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="190" mass="22052" checksum="98C2C2CBA73D492C" modified="2025-10-08" version="1">MSGVPCTILVSIEDRLNFPTKMALVVIRQLFRYGLRSISLRNDRILIDLVYTPKSTTLSRKFGNLPVKYIRMQINDSNEIGLFEKAMKRYYFDLEEETEALPPPPTTTPSIKSIQKEPLKKKLKRRVTQHVESIDLDQNSQVWSFDEHIIDDDDDDKEDHTRRATISETRNDYGDDDDDDCTTTLIPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L858</accession>
    <name>A0ABM5L858_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <end position="639"/>
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            <begin position="16"/>
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            <begin position="132"/>
            <end position="201"/>
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            <begin position="24"/>
            <end position="38"/>
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            <dbReference type="Proteomes" id="UP001652700"/>
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</entry>
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            <begin position="249"/>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31452" checksum="CB72E36D4A31C4A6" modified="2025-10-08" version="1">MARKGGMAYLSSLIIFATTCTIVSALTLNQGTTKPRHTKFSGSTTEGVGPLVTPVSSSASKDDSGVAYYRLFNSKTGATCILLKTDAVVEVQFKLHDLDEKADSFIPEKALIEGDCKDEDAAFMRISWTGYSLVINFAKTPGGERWYISSLGLNISPDLPQFHGIPIQRKSSIKLYHRKMLIPTPVGKSYSCSEVEVSLETDEEDNPPPGIHGILFLRLLQVQPFMYKSEDFETAFECKPQRSFRDETAPIAVGSTLAIAVLVTISGYGAYRYFKVKNVQYNTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0S7</accession>
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        </submittedName>
    </protein>
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    </gene>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="14">Whole insect</tissue>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the NXF family.</text>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="NTF2" evidence="10">
        <location>
            <begin position="372"/>
            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="568"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028128497.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="70732" checksum="FBE32FF700D9FDEA" modified="2020-12-02" version="1">MPKHFNRNRPLAWSNNNVFIEQRSNSDRDRDRRVTFKNNRDRPDRRDKDWSNAIRAHLEDEDIDMGIGPGSSKNVRFNKNKNRGGGGGRGRQGSPAPIQKRKLLEGPSSWYKVTLPHGDKYDKTFILKTLLDKLAPTPFWPISWQVYGTQVNFYVDDFKAAQKLNNLDRQIQLPNGFKLLIRVFAGTPNVEMTDSLKEKIKLTMAKRYNAPTKALDLTKFHADPDLQNYFCALFKPIVFLAVIEIIAENIPDLEALNLYDNKIQLLNFLKKLDKKIPNLKILHIGNNKIRDITELDAFQGLPVVDLLLDGNPVCDKFKDKPTYISEVRKRFPKCMKLDGVDLPPPISFDIAEEQPLPPCQQTFLCNGDGGSIVRQFLELYFVIYDSDNRQSLLQAYHEKATFSMTMAYPYGYSKDSKGVSWLNWYATDNRNLLRVQDPDRRNKLLRQGQVAVVSFLQDMPHTKHDIHSFTVDLTVFTPQMLCLTVAGMFKELKSGHKVPPLRYFFRTLVIVPAGSGFCIANEELHISNATPDQAKDAFKTTVNVAPAPAPVITSPGPSIPQPAVPDDATKQEMVKQMSAVSGMNLEWSLQCLEETQWDYQKAIMVFQNLNAQGVVPQAAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2M9</accession>
    <name>A0A6P7F2M9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Fatty acid-binding protein homolog 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC114325948</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129904.1">
        <property type="nucleotide sequence ID" value="XM_028274103.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129905.1">
        <property type="nucleotide sequence ID" value="XM_028274104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2M9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274103.2">
        <property type="protein sequence ID" value="XP_028129904.1"/>
        <property type="gene ID" value="LOC114325948"/>
    </dbReference>
    <dbReference type="GeneID" id="114325948"/>
    <dbReference type="KEGG" id="dvv:114325948"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028129905.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15243" checksum="1ADDFD699BE837C8" modified="2020-12-02" version="1">MVQIEGIYINDRSENLDDYFLEVGVPFIPRKLLCSSKPTLEIKRENDEWTITVSTLLRTNITTFKLGAEYEEHMPGGVLRNITTLENGKLITLSLGPGDVKSKREYEFTDEGCVITYSSEKTSKVAKRYFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F393</accession>
    <name>A0A6P7F393_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial intermembrane space import and assembly protein 40-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114324668</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128333.1">
        <property type="nucleotide sequence ID" value="XM_028272532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498352.1">
        <property type="nucleotide sequence ID" value="XM_050642395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F393"/>
    <dbReference type="FunCoup" id="A0A6P7F393">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642395.1">
        <property type="protein sequence ID" value="XP_050498352.1"/>
        <property type="gene ID" value="LOC114324668"/>
    </dbReference>
    <dbReference type="GeneID" id="114324668"/>
    <dbReference type="KEGG" id="dvv:114324668"/>
    <dbReference type="InParanoid" id="A0A6P7F393"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028128333.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="15888" checksum="CD58EB065A0EB52E" modified="2020-12-02" version="1">MSHCRRLGPNNKDIVIFATKEDHKIPSKVKLPEAQPPPGLILDNGDINWNCPCLGGMATGPCGVEFRNAFSCFHYSEAEPKGSDCYDLFKTMQGCMQKFPTLYNKDMGDDDNDSASAMASASADSNAIQSSDAKQLKSGSSVDSKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3R7</accession>
    <name>A0A6P7F3R7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jumonji domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114324474</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57156"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15084"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JMJD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128145.1">
        <property type="nucleotide sequence ID" value="XM_028272344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3R7"/>
    <dbReference type="FunCoup" id="A0A6P7F3R7">
        <property type="interactions" value="2256"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272344.2">
        <property type="protein sequence ID" value="XP_028128145.1"/>
        <property type="gene ID" value="LOC114324474"/>
    </dbReference>
    <dbReference type="GeneID" id="114324474"/>
    <dbReference type="KEGG" id="dvv:114324474"/>
    <dbReference type="CTD" id="65094"/>
    <dbReference type="InParanoid" id="A0A6P7F3R7"/>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="123"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028128145.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="52607" checksum="0BCC8E8F35D23A18" modified="2020-12-02" version="1">MFEVDDTVFTKNIAYDYTSIESIPAIEASDLSYSSFFNDFMLLNLPCIIKGITKNWQCLKCWITENNGLNFEYLEEHYGMDMVQVYNCKERFYNTQKSYSCCFSDYINNIKDKPNVLINTSYEYVKNWHLQLNHPEERFYEVPIYFASDWLNEYYVNCMDDDYRFVYMGSNGTWTPFHADVFSSYSWSANVFGKKRWLIFPPGNEEILRNSLGDLPYDVEGKESISIARDCMSIRTESISIAKESISTAKESISSRKESMLIRSGHSSDTDKQCIEVVQNPGEAIFIPSGWYHQVQNISYAISVNHNWVNGCNINMMYESLLRALNDVKEEIKDYSEMDDFEQHCQLMLNAHFGMNFEQFYKFLLYIASKRMEMLQELCPKTLFHGQEIGTNHILFDLQSLKTVLEKFITLDEIKVLDFFSTVSPRPHDLFDEVSLILEIHSIFTNLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6I6</accession>
    <name>A0A6P7F6I6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trypsin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114326839</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131101.1">
        <property type="nucleotide sequence ID" value="XM_028275300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275300.2">
        <property type="protein sequence ID" value="XP_028131101.1"/>
        <property type="gene ID" value="LOC114326839"/>
    </dbReference>
    <dbReference type="GeneID" id="114326839"/>
    <dbReference type="KEGG" id="dvv:114326839"/>
    <dbReference type="InParanoid" id="A0A6P7F6I6"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027634437" evidence="7">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028131101.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26801" checksum="D252EFCEEF7DCB3A" modified="2020-12-02" version="1">MFVLVFLIFLNIFDDCLAHGRIVGGRSAKIEEYPYQLSLRFRNRHICGATLIANNVAITAAHCIPMSGSYTVKGGSTKLSEGGIIIPVKTAILHPQHRSENEDYDVAILRLDTPFNLSSSIQPAKLPKGNEQLVVGWVGNVTGWGAISNNFPDMSDTLRMIGLPVLPIEWCKSRYISVSLTPRQFCAGFKEGGRDSCQGDSGGPFVINGTLYGIISWGFNCASPGYPGIYVNVAVLRDYIQQNSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7D9</accession>
    <name>A0A6P7F7D9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114327317</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131704.1">
        <property type="nucleotide sequence ID" value="XM_028275903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131705.1">
        <property type="nucleotide sequence ID" value="XM_028275904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7D9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275903.2">
        <property type="protein sequence ID" value="XP_028131704.1"/>
        <property type="gene ID" value="LOC114327317"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275904.2">
        <property type="protein sequence ID" value="XP_028131705.1"/>
        <property type="gene ID" value="LOC114327317"/>
    </dbReference>
    <dbReference type="GeneID" id="114327317"/>
    <dbReference type="KEGG" id="dvv:114327317"/>
    <dbReference type="CTD" id="34419"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028131704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131705.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29891" checksum="3FCB533B5B4A8D81" modified="2020-12-02" version="1">MPQNEYIERHRKLYGRRLDYEERKRKKEAREPHKRAQVARSLRGIKAKIFNKERRNEKIQMKKKIKAHEEKKIKKTTEKVSEGALPVYLLDRDVQSRAKVLSNMIKQKRKEKAGKWDVPIPKVRAQADAEVLKVVKSGKTKRKAWKRMVTKVTFVGEGFTRKPPKFERFIRPMALRFKKAHVTHPELKATFCLPIIDVKKNPSSPMFTSLGVITKGTVIEVNISELGLVTQAGKVVWGKYAQVTNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F881</accession>
    <name>A0A6P7F881_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC114327533</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028132003.1">
        <property type="nucleotide sequence ID" value="XM_028276202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028132004.1">
        <property type="nucleotide sequence ID" value="XM_028276203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F881"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276202.2">
        <property type="protein sequence ID" value="XP_028132003.1"/>
        <property type="gene ID" value="LOC114327533"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276203.2">
        <property type="protein sequence ID" value="XP_028132004.1"/>
        <property type="gene ID" value="LOC114327533"/>
    </dbReference>
    <dbReference type="GeneID" id="114327533"/>
    <dbReference type="KEGG" id="dvv:114327533"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028132003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028132004.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46757" checksum="BCDD14328821C484" modified="2020-12-02" version="1">MSGDITNNIEALKVNATEQDDDVVDPWTVTSTKDTGVDYDKLIKRFGCSKIDQELLDRFERITGKKMHHLLRRGIFFSHRDMHLILTNYEAGKPFYLYTGRGPSSSSMHVGHLIPFQICKWLQEVFNVPLVVQLTDDEKSLWKNLTIDEANRLAYENAKDIIAIGFDPEKTFIFSDFDYIGQRPQFYRNLVDIQKHVTFNQVKGIFGFDDSTIIGKIAFPAVQATPCLSSTFPDIFGNKKIQCFIPCAIDQDPYFRMMRDVAPKLGYPKPALILSKFFPALQGAQTKMSASDANSTIYCSDTPKQVKNKINKYAFSGGQATIEEHRKLGGNCDVDISYQYLRFFIEDDERLEQIRKDYSSGAMLTGELKKILIDTLTPLVQEHQKRRAEVTDEILKQFITPRKLNFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FA53</accession>
    <name>A0A6P7FA53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Enoyl-[acyl-carrier-protein] reductase, mitochondrial</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">2-enoyl thioester reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114326242</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028130355.1">
        <property type="nucleotide sequence ID" value="XM_028274554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FA53"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274554.2">
        <property type="protein sequence ID" value="XP_028130355.1"/>
        <property type="gene ID" value="LOC114326242"/>
    </dbReference>
    <dbReference type="GeneID" id="114326242"/>
    <dbReference type="KEGG" id="dvv:114326242"/>
    <dbReference type="InParanoid" id="A0A6P7FA53"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="15">
        <location>
            <begin position="12"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028130355.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37289" checksum="FBFF46359A559B84" modified="2020-12-02" version="1">MPTKIRYANTGEPLDVLYLENYDMPEPEKDEALVQMIAAAVNPVDINIVQGKYPLKVDSPGYEGMGKVIKVGSEVKNLKVGDHVIPIVYAGTWRTHITLPEESLFRIPKSIDVPEGATLQVNPVTMYTMLKEFVNLGPEDTVIQNGANSACGVIAIQMCKAWGIKTVNVVRDRPLIDDLKTFLKSLGATYVFTEEEIKKTDIFKTGELNNPVLGLNCIGGSSATSIMRHLSEEGVLVTYGGMSLEPVTASTTALVFKNIRLEGFNMSRWNNKEENFAKLPKILNEIVDMVLEEKLKAPPHALVDFLNYKEALRNTLSPGGMIGKKFILDFRNLSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FD15</accession>
    <name>A0A6P7FD15_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sesquipedalian-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114329095</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133909.1">
        <property type="nucleotide sequence ID" value="XM_028278108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FD15"/>
    <dbReference type="FunCoup" id="A0A6P7FD15">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278108.2">
        <property type="protein sequence ID" value="XP_028133909.1"/>
        <property type="gene ID" value="LOC114329095"/>
    </dbReference>
    <dbReference type="GeneID" id="114329095"/>
    <dbReference type="KEGG" id="dvv:114329095"/>
    <dbReference type="InParanoid" id="A0A6P7FD15"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13288">
        <property type="entry name" value="PH_Ses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000378">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF53">
        <property type="entry name" value="INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028133909.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="27154" checksum="3291D883CB45500D" modified="2020-12-02" version="1">MKINEKNLCAFAVSATPIDKEGYLNKRGEVNKNFQRRYFVLKGNLLFYFDKKGDKEPVGVIILEGCSIELAEDDAQFSFKIDFHGTNNRSYILGAESQESMEQWMKALACAGYDYMKLMVAELQRQLDDVEETPMPISSPQPVGSPVPPPRTRHNPFNRPENNPHQRSHSLRSTGSAASRLGENRISDNNVASSSSSKITITFRELHNSYGRPILKDYNYWKYEQKEKSDTTENLISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDA8</accession>
    <name>A0A6P7FDA8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Steroid hormone receptor ERR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114329180</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the nuclear hormone receptor family. NR3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134004.1">
        <property type="nucleotide sequence ID" value="XM_028278203.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510078.1">
        <property type="nucleotide sequence ID" value="XM_050654121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510079.1">
        <property type="nucleotide sequence ID" value="XM_050654122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510080.1">
        <property type="nucleotide sequence ID" value="XM_050654123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDA8"/>
    <dbReference type="FunCoup" id="A0A6P7FDA8">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654121.1">
        <property type="protein sequence ID" value="XP_050510078.1"/>
        <property type="gene ID" value="LOC114329180"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654122.1">
        <property type="protein sequence ID" value="XP_050510079.1"/>
        <property type="gene ID" value="LOC114329180"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654123.1">
        <property type="protein sequence ID" value="XP_050510080.1"/>
        <property type="gene ID" value="LOC114329180"/>
    </dbReference>
    <dbReference type="GeneID" id="114329180"/>
    <dbReference type="KEGG" id="dvv:114329180"/>
    <dbReference type="CTD" id="38912"/>
    <dbReference type="InParanoid" id="A0A6P7FDA8"/>
    <dbReference type="OrthoDB" id="5799427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07170">
        <property type="entry name" value="NR_DBD_ERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000139">
        <property type="entry name" value="Estrogen receptor beta a variant b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024178">
        <property type="entry name" value="Est_rcpt/est-rel_rcp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002527">
        <property type="entry name" value="ER-like_NR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="235"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028134004.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="52586" checksum="D5782BB0BACDBA02" modified="2020-12-02" version="1">MFLSAIQKKIQQIFLRLQQVSMMTDTLDGDVSTGCVTHIKKELDGFHECSPSNSDMYSPTTTTTTVLNDNCIKSSNSEVDFHEKSYDRNIRSPTSPERQYCSSTTQPHTDSGIGHMEGEIKEEDSPRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPASGECEINKRRRKACQACRFRKCLRSGMLKEGVRLDRVRGGRQKYRRNPDSPYQVQVVTAQRPMLILEDIKMLEALAGCEPDCFEINKALNNSKHRTLSILSDLYDRELVGIIGWAKQIPGFTDLSLNDQMRLLQSTWAEILTLTLAFRSLSLIGMGRLQFAIDFTLDEKTSRDCGSLELFQTCWNVVERLDRLSILKEEYYLLKALVLTNSDVKLDEYQSLKKFRDSILTALSDTVGILRPTAVLNQVQQLLLCLPVLRQANFVIRRFWSDVHQRDLVPMNKLFLEMLEAYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFI0</accession>
    <name>A0A6P7FFI0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of chromosome condensation isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329778</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134789.1">
        <property type="nucleotide sequence ID" value="XM_028278988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFI0"/>
    <dbReference type="FunCoup" id="A0A6P7FFI0">
        <property type="interactions" value="2167"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278988.2">
        <property type="protein sequence ID" value="XP_028134789.1"/>
        <property type="gene ID" value="LOC114329778"/>
    </dbReference>
    <dbReference type="GeneID" id="114329778"/>
    <dbReference type="KEGG" id="dvv:114329778"/>
    <dbReference type="CTD" id="1104"/>
    <dbReference type="InParanoid" id="A0A6P7FFI0"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="41"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="371"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134789.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="46865" checksum="647236A4A47BB3EB" modified="2020-12-02" version="1">MANKRRRQPSGDKSDHHSKSKRAKFTLESVHLPELDVEGIVLVTGAGDVGQLGLGPDILEKSRPAAVPLDHKVVDICAGGMHTVCLTKEGKVFTFGCNDEGALGRVTEGKEDAEFEAGEVELPGKVIQISAGDSHTAALLEDGRVFAWGTFRDSHGNMGMTLNGNKKSPYEIIKDVFIKKIASGADHIVFLTNHGDVYTCGCAEQGQLGRTTERGSSRNARSGIGKGQIEKLLKPQPISLKASLRLHFDNIWASNYGTFCKVANSEDMYVFGLNNYNQIGLKELNPYFMPTLSKDFSKYNWDTISSGQHHTIALDVDGKVHAIGRKDYGRLGLGKDCEDAVELKPVDTLEGKKVVNVACGSATSFAVTEEGDLYGWGMGTNGQLGTGEEDDCEIPTLIKSKQLQDKKVFRVSSGGQHTVILAIQRDINGHGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG62</accession>
    <name>A0A6P7FG62_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329089</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329089</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133902.1">
        <property type="nucleotide sequence ID" value="XM_028278101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG62"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278101.2">
        <property type="protein sequence ID" value="XP_028133902.1"/>
        <property type="gene ID" value="LOC114329089"/>
    </dbReference>
    <dbReference type="GeneID" id="114329089"/>
    <dbReference type="KEGG" id="dvv:114329089"/>
    <dbReference type="InParanoid" id="A0A6P7FG62"/>
    <dbReference type="OrthoDB" id="424490at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133902.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="37263" checksum="A98FA93A8CE81FE6" modified="2020-12-02" version="1">MATFIVDSKLSCDQMREEFWNMQMLAVPFKNVYDGLVWCASRNLINNSVLCDMCNRAKTFIRRTGVVDQYCWKCKECSATTSVRDGSFFARSSLSIYQIIILMYGFANDFPQKLIRREVSLGNCTKTATRWCLNCRQVCTRYFEQHPVELGGFDEQGEPLVVELDESSFLPRKNLRGADKKEEWVFGGLERKTGKLFLTPVQERKEETLLPLISGTILPGTVIVTNGLEAYRNIGRFGGGVYEHQIILKQNNFRNSDDNTVHTKNMEKLWLRAKKRLSTQWLNSTDLFPSYLQEFMWREQVKHKDPFVEFLICVSEQYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH25</accession>
    <name>A0A6P7FH25_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor Sox-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114330108</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135226.1">
        <property type="nucleotide sequence ID" value="XM_028279425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH25"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279425.2">
        <property type="protein sequence ID" value="XP_028135226.1"/>
        <property type="gene ID" value="LOC114330108"/>
    </dbReference>
    <dbReference type="GeneID" id="114330108"/>
    <dbReference type="KEGG" id="dvv:114330108"/>
    <dbReference type="CTD" id="44275"/>
    <dbReference type="InParanoid" id="A0A6P7FH25"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028135226.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="40049" checksum="EFD0E84D419FA853" modified="2020-12-02" version="1">MLTMETDLKGGNLHGNIPPHHSLQNYGSLSALSQAPMHGLTQHPHQIHHQPQGPQIHHQHQHQSQNHHQQPSHQPQQQNNNNNNSSKAQNMERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLLKKDKYPLGGSTLLPSSDPTRSAPPSVQQVAAAREMYQMPNGYMPNGYMMHDPSAYQQQYGTANYPRYDMGQMQHNYMNGGYGSYTTTVPNSAGSPYGMHQAGSSHSPSGSSIKSEPVSPSSGLHTPTPGGIKREYVGQPQQGDLRQMISMYLPTDGGVQHMQHQYSSSPDPMAQGPLAPLTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIK2</accession>
    <name>A0A6P7FIK2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC114328380 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114328380</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AEBP2/jing C2H2-type zinc-finger family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133050.1">
        <property type="nucleotide sequence ID" value="XM_028277249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIK2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277249.2">
        <property type="protein sequence ID" value="XP_028133050.1"/>
        <property type="gene ID" value="LOC114328380"/>
    </dbReference>
    <dbReference type="GeneID" id="114328380"/>
    <dbReference type="KEGG" id="dvv:114328380"/>
    <dbReference type="CTD" id="35555"/>
    <dbReference type="InParanoid" id="A0A6P7FIK2"/>
    <dbReference type="OrthoDB" id="9984614at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059034">
        <property type="entry name" value="SH3_AEBP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26014">
        <property type="entry name" value="SH3_AEBP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="813"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028133050.1"/>
        </source>
    </evidence>
    <sequence length="848" mass="93560" checksum="866E9AC73153E240" modified="2020-12-02" version="1">MADGLCTDDPIGDVIEKTASNASDNAVLCETTDSITDSGGDKVKDFLIKSESGEIFDDLCAGAGDGAKHEGILEEDCRKKRCVDRYDSSESSDSGVAVLSCTDCSGSSTASSDITDPGSPFSTTSSHSEDSGSGSQPAKMPPTQTAHHPPWPWTADEGPPCKRSLLDKTLTTAAFPKTLKSATAEEQPKKKPTGSATPFITKPNFVKIVPSIPSPNDKLVKKGDSPRMQQGKITEYFKSQVKSNGIKKEILNNMVKKNVTQVTKTLVDQQTQFNSLKTPNRKEIKKPIKKPVQLKVKKVAPVTVPRKILPAPSNMTDKLTISDQLNSLAKFTPTVTLTALSFPPNYTYLHTKGPKPPEAPIFVPQYATIANDKLPLPIINRTPCLNVIQPVQKLTTINNFNCVKLNATVVPIVKVNPMPSRLNTSVSPPVNPVSPVPSLNTSPNIANVMPSSNVPNLSVETGIPTVLSAKPKIADNAVSPIVPLVPQQHNELNVTNTPLENVRVNNSRTEEPHRTEKCTREEIFRDDSKETSPTPTTDSDSGISISTKECLEVFISETVVVEEQKSPILSKPKTIRFPCKQIEKEEGKSHQHSTDGQCRWAECSSCFDTSGALLEHLQVKHVISQATQEHYVCLWLGCKVHGRTSCSRSWLERHVLAHAGTKPFRCIVDGCGQRFNSQLTLERHVNSHFNSDGSPNNNLKKSPENTCKLFKRNGKRIRFRRQPWSARMFDFIDSGIMEGLQFKLLHLTQKRTLGKINEPGNSVHLQSEILARRVETDGCVKFLLRWHPTDIIEDEWVSEKEYKPTRVVSIPHLQPSSKTALSPSLFSPSNEEVQPRQKRSRKQIPKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK51</accession>
    <name>A0A6P7FK51_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sodium channel and clathrin linker 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114331217</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136514.1">
        <property type="nucleotide sequence ID" value="XM_028280713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK51"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280713.2">
        <property type="protein sequence ID" value="XP_028136514.1"/>
        <property type="gene ID" value="LOC114331217"/>
    </dbReference>
    <dbReference type="GeneID" id="114331217"/>
    <dbReference type="KEGG" id="dvv:114331217"/>
    <dbReference type="InParanoid" id="A0A6P7FK51"/>
    <dbReference type="OrthoDB" id="551053at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045162">
        <property type="term" value="P:clustering of voltage-gated sodium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038911">
        <property type="entry name" value="SCLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35970">
        <property type="entry name" value="SODIUM CHANNEL AND CLATHRIN LINKER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35970:SF1">
        <property type="entry name" value="SODIUM CHANNEL AND CLATHRIN LINKER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028136514.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="63880" checksum="050E87A4C45ADF6A" modified="2020-12-02" version="1">MDVAQFETVIADYEAIVKDLTHELRIIQSEHRQLKEKIPLLVGENQRILEELKHYSSAKQLRESVAEEELIQNLKLQIGLVLKEKDQVTQLWRKANRSVEILESELNIYKSDTTEFFPKNEYFRIKEKYEENIRVLDVQLKAVQKRLESKNLEVKTLLQNATDVSESLKASDSKITDLNKKISDLEDACEHCNRKSKEKDKLVQKIMEQNSEYKEKIIEAIEVVQAALNEKDASLLREATIRSEMKKMNDDLDRIIGAIEEKCNKDIVVVKQDAEKRYTDLLDNHRKLQDELNKKILDIEKMQAKNIILQNEIDRFSLGATGTDDSRTSKLLILEKNLESTFQKLLVSEKHNIQVNAELDTVKNDMEQMAAHYERVLKAKDVERLSLQNSINQLESFINEKDISIKSLSNELERQKDKVSNVTKDFETYVENQNKVMAEVENRKYESTALFKEHIKELEAEIDMKEKINKKILEETKDVITKFENGIRKLKHETKTTKKENIVLKTELDNNQKKMSYYKDVLQKIAADTNHITSSHTNLQHVQPNVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK84</accession>
    <name>A0A6P7FK84_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger FYVE domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Zinc finger FYVE domain-containing protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC114328824</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133572.1">
        <property type="nucleotide sequence ID" value="XM_028277771.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133580.1">
        <property type="nucleotide sequence ID" value="XM_028277779.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503769.1">
        <property type="nucleotide sequence ID" value="XM_050647812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK84"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647812.1">
        <property type="protein sequence ID" value="XP_050503769.1"/>
        <property type="gene ID" value="LOC114328824"/>
    </dbReference>
    <dbReference type="GeneID" id="114328824"/>
    <dbReference type="KEGG" id="dvv:114328824"/>
    <dbReference type="OrthoDB" id="68108at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15734">
        <property type="entry name" value="FYVE_ZFYV1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042427">
        <property type="entry name" value="ZFYV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624">
        <property type="entry name" value="AGAP002036-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46624:SF4">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="527"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="638"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028133572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133580.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="78378" checksum="36FDE348BFA5A9CA" modified="2020-12-02" version="1">MLNSVRLKVFEFTKMEKTSLLGNMKTKQPPVGSPIMKSIDPNINNKPEYNNACGDKLPEGLMSLDVTADIDDEYKSTLLLDDNENLRIHSEEEFLKALNIPPNEKVKVVSIFGNTGDGKSYTLNKVFFDGEEVFKTSSSQDSCTLGVWAMYNAKMKVIFVDTEGFLGISKREHQRTRLLLKVLAISDIIIYRTRAERIQRDMYTFLGGASKAYKDHFSSALRKALNKADAQQFAGALGPGVIIFHETRHTDTLHVKSNVTQSTEDILRADFAALGLSYDAFSFIKYIGVQTEGPETNFKDLKVAVLDKLDSTEIRTMRDAKYIYLTLKSLNDKFQTDIQDSTAPLYLPAFFTCTEKCQSCKTNCSLSMGHKEEGEPHQSTQDCTFQHQYQNYVYLCKACYKNGHRSVVKPSYQTMTDNSWSSYLNYVWAGYVIECPKCGEIFRSRQHWYGNKNPEDAAVRAEVVHMWPGNKPFFQERSLFGSLNSAQKVLDGVSMFTDVISHVGSQPKKLLSDWAADKIAPSYWRPNHEIKVCFLCKIPFLPHAKKHHCRSCGEGFCDGCSSKRQPVPAKGWLEDVRVCDSCYSDQPPTLSNMGDPSENRARQIGETVISTISAVTSVLDIPKEYIKESARPTYWTPDNECIECWVCKKQFGPLRPLHHCRECGRGVCNDCSGSRKAVPSKGWDSPVRVCSKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLA9</accession>
    <name>A0A6P7FLA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PHD finger and CXXC domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114328962</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133758.1">
        <property type="nucleotide sequence ID" value="XM_028277957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLA9"/>
    <dbReference type="FunCoup" id="A0A6P7FLA9">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277957.2">
        <property type="protein sequence ID" value="XP_028133758.1"/>
        <property type="gene ID" value="LOC114328962"/>
    </dbReference>
    <dbReference type="GeneID" id="114328962"/>
    <dbReference type="KEGG" id="dvv:114328962"/>
    <dbReference type="InParanoid" id="A0A6P7FLA9"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000138">
        <property type="entry name" value="CXXC-type zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="16">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028133758.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="57975" checksum="7F02451ADCBE7180" modified="2020-12-02" version="1">MSRKRDISREEIAKQFLLPERQSKIDTLLKQDGQAYCICRSSDSSRFMIACDACEEWYHGDCVKISEKEAKLIKQYICVRCKEEDPSLTTRWKTKKEHDETFSLSLGQEERKSRKRKERGENKNDKKIKKCGECMGCYRTEDCGRCDVCTRKNRHSSSKNRERCKQRICVNALGGARRKRRDSSSDREQSHNDHLKTDYPRHCYGPKCTNSARYGSKYCSDQCGMNLARTRILQILPQRLHEWSLTPPAAEESNKKALDQIRKQQVEVQQILQELDKRHRELDVVIERAKNATIDPRLEHNEDEDTETSMYCVTCGLEIHSKTATKHMEKCFNKYESQSSFGSVVKTKIEGSSIFCDFYNAEHRTYCKRLKVLCPEHCKDPKIGDHEVCGCPLVKDVFSSTGEFCRAPKKSCSKHQFWEKIRRAEIDLEKVRQWLKLDELLEKERQIRTSMANRAGVLALMLHSTYNHELMERISAAQDQQNKLNQRDEHVSSRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLZ8</accession>
    <name>A0A6P7FLZ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114331651</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028137081.1">
        <property type="nucleotide sequence ID" value="XM_028281280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281280.2">
        <property type="protein sequence ID" value="XP_028137081.1"/>
        <property type="gene ID" value="LOC114331651"/>
    </dbReference>
    <dbReference type="GeneID" id="114331651"/>
    <dbReference type="KEGG" id="dvv:114331651"/>
    <dbReference type="InParanoid" id="A0A6P7FLZ8"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000054">
        <property type="entry name" value="Complement C1r subcomponent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="14">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="159"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028137081.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="46655" checksum="ED1EF6C812808F4B" modified="2020-12-02" version="1">MYIQWYLQRCEIIFQNFNQTFVYREYNNMVLTHFIFLFVFFLIHSHSNGQDVCTTPGGTEGSCIPALSCEPLRTAFKNVKRPLSDTARKQFEAYICKETHKVCCPKEPIIITELSVRTSDNDESPTETITDITKHKNYGLLPTDCGFVKDSSYVFDIRVVNGEDAGLYEYPWMSLLSFRVPGNIRKFRCGGSIINNRYILTAAHCLEDKSNLLGVRVGEYNLSNNGADKDCDIVECNDPVQDLVIEEIISHPNYESKGKKNDIGLLRVQQITFNNKNIRPVCLPRTSNAKFNQPSAEVSGWGITKFGGRISKVLQKAYLKVVNPVECQNFYQGNLSTAIDDTRLCAGGIFQSSKSNACTGDSGGPLLVQEVSPDREKKYVQHGIVSAGVTRCDLPSLFTKVDYHLEWILDNMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWJ3</accession>
    <name>A0A6P7FWJ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Density-regulated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114333487</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139177.1">
        <property type="nucleotide sequence ID" value="XM_028283376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWJ3"/>
    <dbReference type="FunCoup" id="A0A6P7FWJ3">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283376.1">
        <property type="protein sequence ID" value="XP_028139177.1"/>
        <property type="gene ID" value="LOC114333487"/>
    </dbReference>
    <dbReference type="GeneID" id="114333487"/>
    <dbReference type="KEGG" id="dvv:114333487"/>
    <dbReference type="InParanoid" id="A0A6P7FWJ3"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000004">
        <property type="entry name" value="density-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028139177.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19944" checksum="FEB81E9112BF949B" modified="2020-12-02" version="1">MSVEEKLKQGPREGITYPLQVVYCGNCSMPIEYCEYYPEYEKCKHWLEVNLPSEFEKVKIGDDNPVEEEKKRQKRGGKGMIKTKKKEDGPKQVCVSRAPRGKKKSVTVVTGLSSFDIDLKVAAKFFGTKFACGSSVTGDDEIVIQGDVKDDLFDVIPEKWPEIDEDLIEDLGDQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZ39</accession>
    <name>A0A6P7FZ39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114334243</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140082.1">
        <property type="nucleotide sequence ID" value="XM_028284281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZ39"/>
    <dbReference type="FunCoup" id="A0A6P7FZ39">
        <property type="interactions" value="1968"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284281.2">
        <property type="protein sequence ID" value="XP_028140082.1"/>
        <property type="gene ID" value="LOC114334243"/>
    </dbReference>
    <dbReference type="GeneID" id="114334243"/>
    <dbReference type="KEGG" id="dvv:114334243"/>
    <dbReference type="CTD" id="40388"/>
    <dbReference type="InParanoid" id="A0A6P7FZ39"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22297">
        <property type="entry name" value="PSMD4_RAZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049590">
        <property type="entry name" value="PSMD4_RAZUL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028140082.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="41676" checksum="1B19D5BAD91D9FC7" modified="2020-12-02" version="1">MVLESTMICVDNSDYMRNGDFLPSRLQAQQDAVNLVCHSKTRSNPENNVGLLTLAKVEVLATLTSDVGRILSKLHQVQPNGEINLHTGIRIAHLALKHRQGKNHKMRIVAFVGSPVASEEKELVKLAKKLKKEKVNVDLVSFGEDSINSEVLTTFVNTLNGKDGTSSHLVTVPPGPHLSDALISSPIIQGEDGTGATGLGGSGFEFGVDPNEDPELALALRVSMEEQRQRQEDEARRAKDVSSTETGPKTEGNTVLKEEPSEEALLERALAMSMEQGDEQNVTVARAPVDFANMTEEEQIAFAMQMSMQDAQESSAGASASKLEPMEVEGDEDYSEVMNDPAFLQSVLENLPGVDPQSEAIRQAVGSLKDKKKDEKSEDKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3F5</accession>
    <name>A0A6P7G3F5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bromodomain-containing protein DDB_G0280777-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335504</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141552.1">
        <property type="nucleotide sequence ID" value="XM_028285751.1"/>
    </dbReference>
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        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285751.2">
        <property type="protein sequence ID" value="XP_028141552.1"/>
        <property type="gene ID" value="LOC114335504"/>
    </dbReference>
    <dbReference type="GeneID" id="114335504"/>
    <dbReference type="KEGG" id="dvv:114335504"/>
    <dbReference type="InParanoid" id="A0A6P7G3F5"/>
    <dbReference type="OrthoDB" id="8194276at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF18">
        <property type="entry name" value="CUTICULAR PROTEIN 66D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139281" evidence="4">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028141552.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34995" checksum="2184B7420AD975E4" modified="2020-12-02" version="1">MKNSFKYFLFIWVPSVFCLPEPVSQPAYQTNQYLSAQVLPQVQYKQPEAPGYVQVQPQYVRQQITRPVHEPKREGLQNYATQDQSTQVIFGTSVDRQVQSPDQLQYDFQPLLASQARQAFQVAQQKKYVSEPQQYQTEQYQTQPQQYVVEKPQVRYITKQVPAKQRPQQIKQREEEDYDPNPSYQFGFDVKDELNTNYQNRKEQREGNKITGSYSVVDSDGFIRTVSYTADPKEGFKAEVHRQPTDIVVKIPKPLPQFQAVPKQRVQYVEEQQQPHPQQRRPVEERRQPANVVYQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5F2</accession>
    <name>A0A6P7G5F2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-iminobutanoate/2-iminopropanoate deaminase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114336113</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142242.1">
        <property type="nucleotide sequence ID" value="XM_028286441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5F2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050661952.1">
        <property type="protein sequence ID" value="XP_050517909.1"/>
        <property type="gene ID" value="LOC126892423"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G5F2"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028142242.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15341" checksum="ACA466DC5548D17F" modified="2020-12-02" version="1">MTTKKVICTPFAPGPVNNAPYSQAILIDSKTLYVSGTLGLSVKTGKLVDGGFDNEMQQAMKNLEAILRAGNSSFDKLIKVNIFLEDMNNFFQMNEIYRTYVKKNFPARCVVQAARLPINAKVEIEAIAISGDLAPSECTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDR5</accession>
    <name>A0A6P7GDR5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized MFS-type transporter C09D4.1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114341044</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147634.1">
        <property type="nucleotide sequence ID" value="XM_028291833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDR5"/>
    <dbReference type="FunCoup" id="A0A6P7GDR5">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656634.1">
        <property type="protein sequence ID" value="XP_050512591.1"/>
        <property type="gene ID" value="LOC126888399"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GDR5"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="251"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028147634.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="51905" checksum="7D89E7281E56D4E8" modified="2020-12-02" version="1">MEKELVKHNEVKLLKNSAETKPKIKAYTRRWLIMLLFIYYACVNAIQWIEYSSITHIVVKYYNVSTLAVDWTSTIYMALYPVLVIPASYIIDKKGLRTAGIIGCVGTLIGTSIKVFSIRNDLFSVVLLGQSIVSASQLVIVCLPPKLAAIWFKASEVSTACSLGVFGTQVGCAIGYILPPLIVQDGDVEQIGSQLKILCWLLAGSMVPVTIVVLVYFPKEPPLPPSNAQALLRLNKQEFDTSVFFKSIRDLFLNRGFVIHMVAYSINIAVFSAVGTLLNQFILQFFEGDYENAGWMGFVMVISGTIGSILFGILLDKTHKYKEITLLIYFCSALSIGFLMFTLKYRQKLMTYFSCALVGFFINAYMPVGFELAMELTFPSEESTTSGILFAFTQISGAIMAVALGHFNLWLGAFWSLCSQAVMLFIGAIVTIFVPNCLLRQAAFKENKDLFRKEQYHGSHLVFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GE59</accession>
    <name>A0A6P7GE59_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Jerky protein homolog-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341225</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147821.1">
        <property type="nucleotide sequence ID" value="XM_028292020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GE59"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292020.1">
        <property type="protein sequence ID" value="XP_028147821.1"/>
        <property type="gene ID" value="LOC114341225"/>
    </dbReference>
    <dbReference type="GeneID" id="114341225"/>
    <dbReference type="KEGG" id="dvv:114341225"/>
    <dbReference type="InParanoid" id="A0A6P7GE59"/>
    <dbReference type="OrthoDB" id="6753532at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028147821.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24466" checksum="F6CE600FEA3F882A" modified="2020-12-02" version="1">MDQGVIEKMKRSYRKQLLRRLLLAEKDEESVIEFVKKVNLKDCIYMLADAWESLTETNLQRAWRKLWPYEEEKDDLEEGDIDGAVNEISEICSTLPGFEECNKDDAMECLAVDSNDSGFQILTDQEIADMLNEDETETMESDSDDNSDKTEETGPTHSEAFVAAEALMSWLEKQNESSPTQLILLKRIKDLAAKKRTTTAVQKAITDFFKSSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJV8</accession>
    <name>A0A6P7GJV8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GDP-fucose transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114337741</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144065.1">
        <property type="nucleotide sequence ID" value="XM_028288264.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499128.1">
        <property type="nucleotide sequence ID" value="XM_050643171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJV8"/>
    <dbReference type="FunCoup" id="A0A6P7GJV8">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643171.1">
        <property type="protein sequence ID" value="XP_050499128.1"/>
        <property type="gene ID" value="LOC114337741"/>
    </dbReference>
    <dbReference type="GeneID" id="114337741"/>
    <dbReference type="KEGG" id="dvv:114337741"/>
    <dbReference type="CTD" id="40981"/>
    <dbReference type="InParanoid" id="A0A6P7GJV8"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028144065.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37330" checksum="03C17EDBD7BA48DB" modified="2020-12-02" version="1">MVMENSLLSKYVTIFLVVSGYWIVSITTVFVNKTLLSNINLDAPMFINFTQTLITAVICYFKKSLSDVYPNKFKFPDVDVWDKHTVKTVMPLSLLFTTMICTNNLCLKYASVAYYYIGRSLTTIFNVMFTFLILGETTSKSCIACCAVIISGFWLGVDQENLAGSLSIPGFVFGILGSLSLSLFSIFTKKVLPKLNGEVWALSYVNNVYASILLLPVMILNNEIKELYNYTNFGSPYFWSIVVAGGLCGFTIGFFTTMQIKYTSALTHNISGTAKACAQTVLATYWYQETKSFLWWSSNIIVLFGSACYTWIKQRDMEKRHRENIAYQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNU1</accession>
    <name>A0A6P7GNU1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cathepsin D</fullName>
            <ecNumber evidence="3">3.4.23.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114341097</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acid protease active in intracellular protein breakdown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028147682.1">
        <property type="nucleotide sequence ID" value="XM_028291881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNU1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642818.1">
        <property type="protein sequence ID" value="XP_050498775.1"/>
        <property type="gene ID" value="LOC126879633"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNU1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000066">
        <property type="entry name" value="Napsin A aspartic peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027595091" description="Cathepsin D" evidence="16">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="67"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028147682.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="42086" checksum="E180D2EE6E5F1112" modified="2020-12-02" version="1">MLSKLLIFVFAAVFVSAEINRIPLKKFEKPRDALNRNGLKEGLLAKYNRNVNDDSAVVLTNYLDAQYYGEIGIGTPAQTFNVIFDTGSSNLWIPSSKCGFLEVACLLHNKYDADKSSTYVKNDTRFAIAYGSGEVAGLISQDVVDFGGLQAKDQLFAEATQEPGLAFLVGKFDGILGMGYPEISVNGITPVFNSLVEQGAVQEPVFSFYLNRDPDGEVGGELLLGGSDPNYYKGDFTYVDVSAKGYWQVVMDSLNVGSSLKLCSNGCQIIVDTGTSLIAGPSAEVEKLHKEIGAFSFLNGEYIIDCSKIDQLPEISFVFGGKEFTLSGNDYVLKQSNGGIDICISGFMGLDLNTRTHVEWILGDVFIGKFYTEFDFGNNRVGLAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GS01</accession>
    <name>A0A6P7GS01_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 239-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114342244</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148832.1">
        <property type="nucleotide sequence ID" value="XM_028293031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GS01"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642326.1">
        <property type="protein sequence ID" value="XP_050498283.1"/>
        <property type="gene ID" value="LOC126879256"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GS01"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028148832.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43564" checksum="2020970DD2EE55E3" modified="2020-12-02" version="1">METKEDVKYIKVEVKEEYEDDLESKISTYTPISSEIKIEDVEGFAKDEPGIFLPEIKMENMKTETKDFSNKIHDSLDDTEKEKFSECEICHKKFKERKHLNQHMRRLHKERKSLECEICSKSFSAGFSLRNHMRIHTGEMPFQCKICSRKFTRKDFMKKHLITHSEEKSYTCEVCLRPFSLLSNLQRHIRIHTGEKPYQCDICLKQFSDNNHLKRHTRSHTGEKPFKCNFCPKAFSQQCNLTSHITIHTGEKPYNCEICSQQFSRPSNLRSHMVVHSGEKPYKCDICSKQFSRSFHLKDHIRGHSGEKPFKCEFCSKEFSQRCNLRSHVRLHTNDKPYKCDICYKELSRGCHLKRHMLLHVNETPVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9Y0</accession>
    <name>A0ABM5I9Y0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 19</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128248.2">
        <property type="nucleotide sequence ID" value="XM_028272447.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272447.2">
        <property type="protein sequence ID" value="XP_028128248.2"/>
        <property type="gene ID" value="LOC114324582"/>
    </dbReference>
    <dbReference type="GeneID" id="114324582"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF6">
        <property type="entry name" value="OSIRIS 19, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045550975" description="Osiris 19" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128248.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23560" checksum="67B0B99E8E0A3E0E" modified="2025-10-08" version="1">MGRIFLVFVLVGAAFGNPAPNLGQENEWEQLLKVGSNVDIKSNAIETGRSAAGSIEDHIERYIKSHEATFDLPFIGSKVTLDGKNLDDEEMSIKLNFGTDVQARKKKSKLKKLVVPILVFLVIKAMILIPLALGILGIKAWNATQLSFVSFISALGMAIWKLCTKVSHEPPQIIHQTYDPHSHHFHHDHHDYHDRSDAPQQMAYAGYVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAF7</accession>
    <name>A0ABM5IAF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128524.2">
        <property type="nucleotide sequence ID" value="XM_028272723.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272723.2">
        <property type="protein sequence ID" value="XP_028128524.2"/>
        <property type="gene ID" value="LOC114324844"/>
    </dbReference>
    <dbReference type="GeneID" id="114324844"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128524.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="243" mass="26895" checksum="0D54B516B042429C" modified="2025-10-08" version="1">MNSTLFDVFRTAALLVLTPKCFDNYFLEFNYLDGPCFFATLSKGLGFGIILGSLTVKVPQILKILNNKSGEGINILSVTLDLSAITIYMAYSFVKGFPFSAWGDASFLAIQTVLIGYLVLYYQGAITKAITYLLVYVTVCYVMMFGMTPLEFLWSLQTFNIFLVVVGKLMQAYTNLQNGHTGQLSAATLIMLLAGSLARIFTSMQETGDSVVILTYIASSLSNAVLVVQLLYYWNVDPKKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IH18</accession>
    <name>A0ABM5IH18_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132593.2">
        <property type="nucleotide sequence ID" value="XM_028276792.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276792.2">
        <property type="protein sequence ID" value="XP_028132593.2"/>
        <property type="gene ID" value="LOC114328049"/>
    </dbReference>
    <dbReference type="GeneID" id="114328049"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF10">
        <property type="entry name" value="LP14110P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046018324" description="Osiris 2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132593.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38653" checksum="0ADBC28F2C0C76E3" modified="2025-10-08" version="1">MFGVSKWVFLLSYMSLVALQSIGQDGNFRSQEVIDNNGPQGRNLLDWIGFGTGPETDPYLARTNGACLNGDLAECFKSRALASFEDFFTKPEYYLSENARIRRMPETQLRQLSQEPYEYSESPRADEPEWDQLLKFGKRKLEKFLKSTVFELDFDEEVTERGRYSPRFIDEIAGEIDIIEDKKDTLFKRKQLKKLFIPLLLVLKLFKLKLLLFLPLILGLASFKKLLGFLALIIPGAIAFFNFCKPILKQNGGSFFGPVGPQYSPAGVAYQQHYSPNYHHQQYSDYPHHGYGSGVHFRNDEDSAQHLAYNGWREYRSKDKGIEAEVTPTKKSILPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHC3</accession>
    <name>A0ABM5IHC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132782.2">
        <property type="nucleotide sequence ID" value="XM_028276981.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276981.2">
        <property type="protein sequence ID" value="XP_028132782.2"/>
        <property type="gene ID" value="LOC114328196"/>
    </dbReference>
    <dbReference type="GeneID" id="114328196"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF12">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047478023" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="2">
        <location>
            <begin position="244"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132782.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="388" mass="44056" checksum="F23091E6E6E267AC" modified="2025-10-08" version="1">MLLIFCVVALLRVSNGEIFDFADEDPLNSVWPQGERIKLKTTECQVQTQNGVKWGQCVPYASCLLSQGTPNGFCGILQTCCVYESTCGKTSNAKVSYFETTELGNGQTNCEYIVNLRNKNICQIRLDFIKFNLAPATLTTPQYASYKSYRCVDDIFRVTPNHFNIPDLCGNNDKQHVYIHVNQTDGVTKGVQLQMTLANRNYNPLLFSPTWRIKITQLECPGHRSGINFGENKDIIEDFPLLAPLGAIQYFSESTGYIKSFGFDGSVSNQQSYTYGQQYAIAFKREIGVCGIRFVPDYMYLPYDNSLGLHGDNDCMHYLYVPELYFDDLMSPSNSLISKVCLNQPEDFRSYAPGPFYVHFNSQKTNFTTDEEKKQGFNIKYQLLSRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IL20</accession>
    <name>A0ABM5IL20_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135319.2">
        <property type="nucleotide sequence ID" value="XM_028279518.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279518.2">
        <property type="protein sequence ID" value="XP_028135319.2"/>
        <property type="gene ID" value="LOC114330190"/>
    </dbReference>
    <dbReference type="GeneID" id="114330190"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135319.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="125" mass="14234" checksum="22E8B9B07AD45516" modified="2025-10-08" version="1">MKSELSPEAPIYIPPPLRNATPKSSPSSTKSSPGSNSKEPQCSRYSRKNIRSMIENENSPRPILGNYVSTPRPILGRGENNIRKVKDDADKYIGREFRRSFKKVFKEEKSLSVVEDENMEEDECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IN25</accession>
    <name>A0ABM5IN25_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein 21-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136912.2">
        <property type="nucleotide sequence ID" value="XM_028281111.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281111.2">
        <property type="protein sequence ID" value="XP_028136912.2"/>
        <property type="gene ID" value="LOC114331515"/>
    </dbReference>
    <dbReference type="GeneID" id="114331515"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045549639" description="Cuticle protein 21-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136912.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24077" checksum="682235B3C5F67C22" modified="2025-10-08" version="1">MVFKFVTFCALVAVAKAGIYGETYSAPLSYAAPVAKVAYSEAPAVSYSSVSAPVAYAAPAIAKVAAPISYSAPAFSYAAPALKVAAPVAYAAPAYKVAAPVAYAAPIAKAVYAEPSAPAHYDFGYAVSDPHTGDSKSQQESRHGDVVQGSYSLIEADGSKRTVEYTADPHNGFNAVVHKEPAAVAVKAVAPVVAKIAAPYYAQPALKVAAPIAYAQPALKVAAPLSYASPLAHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INT1</accession>
    <name>A0ABM5INT1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137608.2">
        <property type="nucleotide sequence ID" value="XM_028281807.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281807.2">
        <property type="protein sequence ID" value="XP_028137608.2"/>
        <property type="gene ID" value="LOC114332095"/>
    </dbReference>
    <dbReference type="GeneID" id="114332095"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046529899" description="Carboxylesterase type B domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137608.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="163" mass="18852" checksum="665F5B2059FF2617" modified="2025-10-08" version="1">MRNTIRQFLFFSFLFLLFTYPSKSDMILDSKPQLTSRTVRTKYGDVSGVIFSLDSKYLEPVEVFRGIPYASPPLGSLRFMPPVTGALWQGVKLADRFSPVCPQRLPDISNETAALRRMPKGRLEYLKRLLPYLKEQSEDCLYLNIYAPAQGRINFLELIKKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQI9</accession>
    <name>A0ABM5IQI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transferase CAF17 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138853.2">
        <property type="nucleotide sequence ID" value="XM_028283052.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283052.2">
        <property type="protein sequence ID" value="XP_028138853.2"/>
        <property type="gene ID" value="LOC114333200"/>
    </dbReference>
    <dbReference type="GeneID" id="114333200"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="262"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138853.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39436" checksum="6AF4E6A557A74D6A" modified="2025-10-08" version="1">MLKLSKIFNITNIRFCSNAATRTILEPLKNRSLIHVSGNDSTEFLQGLVTNDINHLSQNFHSMYAMFLNTKGRVLYDSIIYKFETDNSYFIECDLEIEKQLEKHLKMYRVRKKVDVTNACDKYQIYVLFKNNCLKTEDVQLEKNIVDSTAAQESAPLQTTKKMFIFKDPRVADLGYRIIAKNDVDIEKEISSSVITESPTPEENYKYLRYSLGIGEGVNDLPVGNCFPLESNCDYLHGVSFHKGCYIGQELTARTHHTGVVRKRLMPLLFIEPPNSLPSDNVLKSDQVNLGKLRGTEQNLGLALVRIESALNLGQFKVGNGLAKVWKPHWWPVELPKEKQKIQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ITF8</accession>
    <name>A0ABM5ITF8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141381.2">
        <property type="nucleotide sequence ID" value="XM_028285580.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285580.2">
        <property type="protein sequence ID" value="XP_028141381.2"/>
        <property type="gene ID" value="LOC114335353"/>
    </dbReference>
    <dbReference type="GeneID" id="114335353"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF22">
        <property type="entry name" value="MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="266"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141381.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="428" mass="48864" checksum="E6ADAE524FB357C8" modified="2025-10-08" version="1">MDVMESPKKSFGNNVQNNTSKTTHFQVPSSVLIDEINDVGSDCVDKNVTLKNATNFHPLMSPISQDFPDLIPKQAKVNIYEEHFHPEAHSSVNELYEPGERQNEDLSTDLPEFPSSPSLLRKSILGDVSVEMTPNDVISDTEYENDKSVYEAHLSSNLQNVSLKLNEKEGNLNFLAHNKRSNKLRKIKVVQTQLSDDSDVSSADTNTDSLKSEDVFNGEVEEFARKLDDENTTPEPIEPLSAADERCHARYWQRMVLPGGEQRTIDMRVIEPYKRVLSHGGYLRAGGNTAIVVFSACYLPDKSRIDYVYVMDNLFLYVLWTLERLVTEDYVLIYLHGAANKLPSFGWLKRCYQMVGRKLRKNLSHLYMVHPTLWIKTMLFMAKPFISSKFYRKISFISTLRELMVRVPLEAAAIPDKVKLFDSLHFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXC1</accession>
    <name>A0ABM5IXC1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G2/mitotic-specific cyclin-A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146849.2">
        <property type="nucleotide sequence ID" value="XM_028291048.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291048.2">
        <property type="protein sequence ID" value="XP_028146849.2"/>
        <property type="gene ID" value="LOC114340306"/>
    </dbReference>
    <dbReference type="GeneID" id="114340306"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20504">
        <property type="entry name" value="CYCLIN_CCNA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="234"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="327"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="331"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146849.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="52353" checksum="BB02012225254D7F" modified="2025-10-08" version="1">METIQNENKENFVHEMQKQSAMAVPQKRPLGQRNTNVDPQPVQLKEKQPLTVPSSFNAFKEQFERNKYKGTKNINKENYCQKGNKNIVNPVIPCNQFKDFKVFEDEQYPEEKLKNLAAKNPPKVQVHEDTKEETKDEVKAPEKIVEKENIKQDSESLSLKTSDAHLFMTIDDNYKKDHEIPSTKRMKDIFFEMEEYRSDIYHYLREHELRNRPKPGYMKKQPDVSSNMRTILVDWLVEVAEEYKLHTETLYLAVNYIDRFLSYMSVVRAKLQLVGTAAMFIASKYEEIYPPEISEFVYITDDTYTKKQVLRMEQLILKVLSFDLSIPTPLTFITAMCVSNNLSDKTMYLAMYLSELALLNGDIYLEFLPSVIAAAAIALARHTLCEEAWPKELVQSTGYEGLQIRSGISFLYQMFVSAMTLPQHAIQDKYKTRKCMHVSTLKPRDVALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZ03</accession>
    <name>A0ABM5IZ03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150846.2">
        <property type="nucleotide sequence ID" value="XM_028295045.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295045.2">
        <property type="protein sequence ID" value="XP_028150846.2"/>
        <property type="gene ID" value="LOC114344195"/>
    </dbReference>
    <dbReference type="GeneID" id="114344195"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150846.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="512" mass="60496" checksum="3505BD21FA36729A" modified="2025-10-08" version="1">MSAMDFKVEIKDEPVEYIQKDTESQLSTSIDLENFKNEKEDKSEMGLNAEIKEEFSDSCQVYTKDQLFTSPDLKDLVNEADEDNSGFSQNGMEFMKTELECSTEQQINVNTEETSNNSIYKCKICFEQFCQAGSLKRHIKTHTAEKSYKCEICLKHFTRAHDLKRHLKLHNGETPYKCEICLKHFTRPQDLECHLRVHTGETYKCEICLKKFTWAQDLKRHLKAHTGETPYKCDICLKQFVQMHDLKIHFRVHTGEKPYKCEICFKQFTQTSHLNRHIKVHTGEKPYKCEICFKQVTTKDQLECHLRVHTEEKPHKCEICFKQFSHAHSLKSHLRVHTGEKPYKCEICLKQFTQKHHLNDHLRLHTGETPYKCEICLKEFSQKIHLKNHLRLHTGEEPYKCEICLKQFTYKKSLDAHMKLHNGEKAFKCEICLKQFTRADELKRHLRVHTGEKPYKCGICFKQFSQAHRLKSHLRVHTGEKPYKCEVCLKQFSQKHHLNDHLKLHIGETPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH03</accession>
    <name>A0ABM5JH03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497213.1">
        <property type="nucleotide sequence ID" value="XM_050641256.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641256.1">
        <property type="protein sequence ID" value="XP_050497213.1"/>
        <property type="gene ID" value="LOC126878506"/>
    </dbReference>
    <dbReference type="GeneID" id="126878506"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23530" checksum="C3C43022B4C9C764" modified="2025-10-08" version="1">MVSLDGEMIVKSNSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVAEMRMLRWMSGVTKKDKIRNEYIRGSLGVAPIDAKMREHRLRWFGHVQRRDLNHPIQRIAEVQIPGRSRRGRPKKTWGETIRQDMLVKGINIDMTQDRIVWRNAIREADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI56</accession>
    <name>A0ABM5JI56_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497620.1">
        <property type="nucleotide sequence ID" value="XM_050641663.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641663.1">
        <property type="protein sequence ID" value="XP_050497620.1"/>
        <property type="gene ID" value="LOC126878768"/>
    </dbReference>
    <dbReference type="GeneID" id="126878768"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="191" mass="22015" checksum="89F2AE83BD0A3A23" modified="2025-10-08" version="1">MDISDLKQRVICQHHYAVEHIYQSDQTKLLRKNAVPLKFAQLATDLGDTPPVLCSTYVYCGTKRKKSTSGDCMVRSTPSPKRSSSSLSDISSFDINLPTKLETELTEKVKKLEYQVNALKKKCRQKNSQRCRRTTKNRKSATKFMIEVLLENKSIYVHTFVNMQFSHKTRSQWSHNEKDLALAIYYKSPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIC3</accession>
    <name>A0ABM5JIC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497689.1">
        <property type="nucleotide sequence ID" value="XM_050641732.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641732.1">
        <property type="protein sequence ID" value="XP_050497689.1"/>
        <property type="gene ID" value="LOC126878818"/>
    </dbReference>
    <dbReference type="GeneID" id="126878818"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="315"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="815" mass="94436" checksum="04850C63DB373928" modified="2025-10-08" version="1">MVVDFSKYLRLSKKRELLNIDIWFIHKCIKFKVTPTFAKCKVPSTATLNFKSQIERKFLQKELCKHHAHLDKINVQLKILYDNIVREVPFDNFRDSIANHLDNLEYIKQSKFNRVNNKLHNLIKKKNNLNSNSQNTNRLMGSFKFRFHKRTVNLSTCSFTNKELDFLSNGLKFSTLVPFNNKMVEEFSVDIDTVIESLPLDNISKTNLKSNCFLSLQKDLIKFNNNVNNIKTKCFKQLHLIRQLSFKLKSNNLIITKADKGNCLIIMHHSDYVQKTEEFLRNNNFDILDRNPLNKLITNLKNTLSKHKDFLQLHKTKEKTFILSNPQIPRLYGLPKIHKPNVPMRPVVSFYNTPVVTLSKFINSILQSTITLQPSYSVKNSTDLVNKLSVLNLPRDFFLVSFDVSNLFTNVPRDETIPLVEDLLIKSNINRVSIPHLLDLLKFCLSQDFFTFNDIIYRQAQGLAMGNPLSPLLADLFLNNLEVNIFDNNSSNQNSFQKILYWFRYVDDVLAIIDGNSTDAENILYLLNNLHPAINFTLETESNKSINFLDLTLTRMDSKLIFSVFRKPTQTDHTIPRSSNHPFQQKMASFYCYIHRLLSLPLSDTNFNSELDIIKQLAYSNGYSPTLVDNILNKLRSKRNRSLAYNPVLNNSTTAVMYRSISYIGYPSDNIAKILNNIPNLKLSFKCKESIKSIFSHTKDKIGKTSKSGIYKLSCGDCPVTYVGRTMRPLETRIKEHLSKIDKSSFGNHLHASKHNFSPQRDSRILHSIPINNYTKMNLLEDLEISRELKRNPQNCVNTQVQLNCKFDPIFKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJB1</accession>
    <name>A0ABM5JJB1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050498023.1">
        <property type="nucleotide sequence ID" value="XM_050642066.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642066.1">
        <property type="protein sequence ID" value="XP_050498023.1"/>
        <property type="gene ID" value="LOC126879117"/>
    </dbReference>
    <dbReference type="GeneID" id="126879117"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045589119" description="Alpha-1,3-glucosyltransferase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="516" mass="59370" checksum="AFD2876D1092C1A3" modified="2025-10-08" version="1">MIFTTTFLTSCLKLLLIPAYRSTDFEVHRNWLSITHSLPVKKWYFEDTSQWTLDYPPLFAWFEYILSFPAYLFDSKMLNVNHLNYSSEKAVLFQRLSVIITDLVYSLGVYMCCCSVKKSWGKEVVLPILLITNCGLLMVDHIHFQYNGIMYGILLISIAYMIQEKYLQSAFWFTILLNMKHIYIYLAPAYFIFLLRHYCLKGPLVIRNIFSRKNLKNVGMLGCTVLGIFVVTFLPFYDQIPQVLSRLFPFKRGLCHAYWAPNLWALYNTVDKVGFVLASKLNKNLVKNDTASMTGGLVQEFSHSFLPNVTPVATIILTAVFMVPAMIKLFRAEKQPFQFVRCMVLCALTSFLFGWHVHEKAILMAIIPLSILSIINQRDAKVFLILSTVGHYSLFPLLFPSSLLLIKVLLLVLYALYSFHSLSKLYPSLTPCICSFSLPLLSIYESVYLLGLGAIFFYENAVHVALGLNSKLPFLPLMITSVYCAIGVIYCWLYYYYYFLRSRDEVSAVSNVKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKK7</accession>
    <name>A0ABM5JKK7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050498470.1">
        <property type="nucleotide sequence ID" value="XM_050642513.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498471.1">
        <property type="nucleotide sequence ID" value="XM_050642514.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498472.1">
        <property type="nucleotide sequence ID" value="XM_050642515.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642513.1">
        <property type="protein sequence ID" value="XP_050498470.1"/>
        <property type="gene ID" value="LOC126879480"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642514.1">
        <property type="protein sequence ID" value="XP_050498471.1"/>
        <property type="gene ID" value="LOC126879480"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642515.1">
        <property type="protein sequence ID" value="XP_050498472.1"/>
        <property type="gene ID" value="LOC126879480"/>
    </dbReference>
    <dbReference type="GeneID" id="126879480"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF118">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="361"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="503" mass="57240" checksum="2F81F2A9DA2DBF74" modified="2025-10-08" version="1">METSEISKWYRNQHVFITGATGFMGKILIEKLLRSCPDVAAIYVIIRSKKGKNATQRLEELLNSVVFDNIRQLPDAKSIFEKVKCITGDVTEENCGISPKDQELLEKSVTSVFHMAANVKFDLTVKTAVLLNTGGTFNVLEWACKLQNLKIFVHVSTSYCHCDVTELEEKLYDAPQDPRKMLDMVKWMSDDLLETLTPKLLSKYPNSYAYTKGLTEQLVSEYSTKLPIVITRPSIVFAAYKEPIPGWIDNLNGPTGILVGAGKGVIRTMHCNAELNTDFVPVDMTINSLLTVAWKVGTGPKKSEAEVYNITANRDDSVNWGTALEICKKHVFNYPYSVMLWYPGGGPKSNYIVHCIAAFFFHLVPAYFVDMLLTLTGNKPFLINIQKKISHGLKILQYYTIRPWYFHNDKFAKLYDSLNTTDKEIFYGNREKLNHDEYLENYVLAVRKYCVKEDPSTIASARKTLNRLYFLDLLKDILLYGLLLWLFYGFVTRLLVAVGNPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKU1</accession>
    <name>A0ABM5JKU1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498556.1">
        <property type="nucleotide sequence ID" value="XM_050642599.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642599.1">
        <property type="protein sequence ID" value="XP_050498556.1"/>
        <property type="gene ID" value="LOC126879517"/>
    </dbReference>
    <dbReference type="GeneID" id="126879517"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35070" checksum="08063E6457994C35" modified="2025-10-08" version="1">MSDGRKRLSGAQYKTLAEEKRRKLHAVLDKTKKLNNYFLIKPTTTTSKAQTHDSDSESETVTAVSAVPIPPDNAEAMDTEPSERSESKIEASACASASVNPQCLQAVISNDPAEWKANDATIDYLLSLPSEICQNTDEDFSLTKTVIGNKTRYLTKNVFRRKLANEEEQPRRYLIYSPSKKSLFCIPCRLFGGTSKMATDGVNDWSNVNKILNLHENPHEHAKSQVTLLRRQQKQNQIDSLLCQQIRLEEDYWRKVLKRVVAVTKKLASRGLPFRGTVEKFGNPNNGNFMMCLELISWSSHLQYVKNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSF0</accession>
    <name>A0ABM5JSF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500872.1">
        <property type="nucleotide sequence ID" value="XM_050644915.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644915.1">
        <property type="protein sequence ID" value="XP_050500872.1"/>
        <property type="gene ID" value="LOC126880846"/>
    </dbReference>
    <dbReference type="GeneID" id="126880846"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="648"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="735" mass="83342" checksum="D16848476B5CDF12" modified="2025-10-08" version="1">MDNSKPKQKTLTSFFSASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEGKLGCKVCFEVTTMGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKAIFRSAYYIAKNDRPYNDHFGLLEFDGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVSGKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHLGVAKRFSTLYPDIIVWHCLNHRSELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVMSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSG5</accession>
    <name>A0ABM5JSG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500882.1">
        <property type="nucleotide sequence ID" value="XM_050644925.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644925.1">
        <property type="protein sequence ID" value="XP_050500882.1"/>
        <property type="gene ID" value="LOC126880856"/>
    </dbReference>
    <dbReference type="GeneID" id="126880856"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30249" checksum="E4CD472D172CF9EC" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANITSDPTKFNYIVANLDTAYILEVRDIIVSPPATERYEKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSHFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAPRAQISEAPNALESTIEKLTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRGRPYPRDRSYSRERNSDICWYHYRFGDQAQKCSPPCKHQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JST0</accession>
    <name>A0ABM5JST0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apoptosis-antagonizing transcription factor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500985.1">
        <property type="nucleotide sequence ID" value="XM_050645028.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645028.1">
        <property type="protein sequence ID" value="XP_050500985.1"/>
        <property type="gene ID" value="LOC114330891"/>
    </dbReference>
    <dbReference type="GeneID" id="114330891"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="208" mass="24497" checksum="32BB22D9C2C5699E" modified="2025-10-08" version="1">MNDDPDNEEVPSDTEDEVDADLSEDENEESPKKRLKITDFGNDLQQKHNLYKDHRNSVIKKWHEKTRMPVLKNMTNNHSIIQHIEHSLGDKDKLIKRTRLKRSDYKIIGEDSASDNEEESTQEKPSEEYNSEIFDDDDFYHQLLRELIEFKSSSLTDPVQLGRQWVQLQNLRSKMKRKIDTKATKGRKIRYAAHTKLVNFMAPIDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTI8</accession>
    <name>A0ABM5JTI8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Venom acid phosphatase Acph-1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501247.1">
        <property type="nucleotide sequence ID" value="XM_050645290.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645290.1">
        <property type="protein sequence ID" value="XP_050501247.1"/>
        <property type="gene ID" value="LOC126881189"/>
    </dbReference>
    <dbReference type="GeneID" id="126881189"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF19">
        <property type="entry name" value="GH19849P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046458202" description="Venom acid phosphatase Acph-1-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="42057" checksum="A640EAFC3329C823" modified="2025-10-08" version="1">MEWCKHYLKCIFYYILLHQVTGESMIQQLHVIFRHGERAPTDTFPSDPYINYSWPGGWGQLTNNGKLQMYDLGKLIRTEYKNFIPDLFWHKDVNITSSYSERCRMSGQLFMSGLYPPVSSQIWNQEFLWQPVAVRYLPRSEDTNIVMKVACAKYDAMFKELRQSPAILALESKHEELKKYLTKHTGSNVTNMENVESIYNTLEIERLHNFTRPSWVNDTMLATMGELAARNLAFYSEVPYMKKVKGGMFLNNMIKTMENSLNKTDVTKLYLYAAHDLTIVHILRSLNLIETLKPGFGATLIFELYANSGIKITYRNFWKDTPKEYHISQCELSCPLQKFKSLLSDMLPTDYTKECVLEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUB6</accession>
    <name>A0ABM5JUB6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501531.1">
        <property type="nucleotide sequence ID" value="XM_050645574.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645574.1">
        <property type="protein sequence ID" value="XP_050501531.1"/>
        <property type="gene ID" value="LOC114338438"/>
    </dbReference>
    <dbReference type="GeneID" id="114338438"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1602"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1751"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1803"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1848"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1891"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1981"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2179"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1809"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1853"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1891"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1919"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1946"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2002"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2192"/>
            <end position="2205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2317" mass="259042" checksum="1B33E609472EB959" modified="2025-10-08" version="1">MISVLRNVCKLKIPTRCVRTPHSLRPLRRMEKPAPGFPKYSVNSRSFRSLTTTSPQKNSFNLPTGTVNSNFRRHFPQKIKFGHPRSAASAENNKRDDISYEQYLHLQKEKQEKMHNSKLNKFCSSSQYKNKYLERTSSKQKRRHFTSEVKRVPYPKFLMPFQPKLQLYMTKRNYSTNRSLKGVAGDDDCFQYFQDRPIKKPSLQVPREQFATPVTPDFRNHRTGLPTNAQYGYNMPQKDNITADHKESQGITENESNIPQVADTSGTNTQHISKSQLPSVEVWTTQRPDSIFEGKTTRNTSGIINNLEVEINKKMEILSLKKSDKENQLSTALRQKKGPIIIQVVKKQTALKQTPNEKSGYTLNMVSSYQNTPNSKSLKGQRKSKKSKKRPSQNKKSTSVIQEKTNNNSNNNPKTITRTSVLENCRGIFNTLYRKIKGPQKRNAGSFHLEPPNMIFKDTVYPKTPLSQRNPKSKVSILLKDKYPWNSAQLDETFLLPKDHRETAKRMFSAKTKKNPYYPKDFSYSTNSSSKDKSTSNKVKYPWNLATDQIESHKSSRIVYCNPNNISATEPDLPKMDYIEQKSPLVVCRALENASYRKDNNYHKNTSNKKPEIPSLPFSACTNNVIIDKDIPNPPASTCKSNFTKNLCVQLPTSQCCVKNTIKQQNLENGETAKIKIPDPPLSTCTKNVTQTNQSVHENNIMNLLDDCKNLCKSTCTKNAFVQIQQDSDKKDIQNVLNTCKSIPKTTGMKEPTIKIEIPDPPSSTCTKSVVSQIKQESDKKDMLSILDACKTVTKSTGIKEPTIKLEIPDPPSSTCTKTVVSQINDTCKSIPKTSGIEELAIKIEIPDPPSSICTKSVVGQKEPTAKLEIPDPPSSTCTKNVVSQINETCKSITKTSPIEELASKIEIPDPPSSTCTKNVVGQKEPTVKLEIPDPPSSTCTKSVVSQINDTCNKSIPKTSGIEELASKIEIPDPPSSTCTKSVVGQKESTAKLEIPDPPSSTCTKNVVSQINDTCKSITKTSAIEELASKIEIPDPPSSTCTKNIVGQKEPTAKLEIPDLPSSTCTKNAVNQINDTCKSIPKTSGIEELASKIEIPDPPSSTCTKNVVGPKEPNIKLEIPDPPSSTCAKSAVSQINDSCKSIPKTSGIEELTSTCTKNDVAQKEPTAKIEIPDPPSSTCSKSVVGQVKQNLNKTDVLDVLDTCKTATESTVRKETSIKIEIPDPPSSTCTKSVVDQVKQYSDKKDIVNKIDKCKTVPSNNVTKEASDKIEIPDPPSSTCNKSASNRPKITCTNQSDIGIENANGPYRSKQQLCNEPRTDEYSSGPYRSIQQVCKRTRSSSKEPTLAGSSNSNSSKNCDKAKVKQKTSKEPTCNNKVTKKEQNQNKSTGTKKEEVKKSSSCNELKKPPNSSTSKTKVSNYVKPKDVYCNPRPTIQTKEFKETKKSSCREKCIEEIKKKKQEISKESKCKNQKEEKKQEVAKNSNKSNKCEDKNKKVDIQKVKVQDTCGMVLKNSSNEKIDKCNKKNATKSDTKKKLNPNEKAENLTTNATNAYCSENQQCFPQTRVLKENLCDLCAFKKAHVLPGTEDFDPNKKATNLLLKSTSTPSDCDKRYHESKFDTKRTDSNAKKPSPKYRSCVNIKANRNENTSSKRQENTCTESKKNNAEAKRSESENSIKTCTNKDISKEDIRKRGICSDIKRPEMGRPVKLVMKENIGADCSSKKKKMESKKECPKPKQLEKCDQLVKEFLNKSKGEGDKKVNIKKDCSEPKKESTKPKESKKGNCDQLIKDALCKSKVEKKAQKIIRSTKSKRDCSQPKTEDPKLKKTANCDELVKQFLLKSKSDYLTKPKKADKKMDSKKDCSKSITKCATPKQSEKCDQLVKEFLLKSKGEKKTEAKVDPKKDCSRPKTESSKTNQPKNCDDLVKEFLRKSKDLGDFSSKRKTNQKKNDSKKDCSKSKQKCATPKQSEKCDQLVKEFLLKSRGGSKSGKHSGAPATPACSGKSNNSPPSSSVKPSPVKAASSPSVNLNRYHLPKSPNADSTKLTKQKDENSSIDLSNPSTILDLTNAVNKAREMLPLQKISEPKKSNARPSIAYHAKNTPKTTDKHTTSASELTKRTDEEDHLYNKYQKLTLDIFHPFTIEDQTKDTKIGKTKSTVPYTSKFDTLNKETLKNQIDNTTNKIKTPLPLKSQRSKSTPSLTISASSHPQHKQQINDHPIFESERCKENETSCLPIFKEIENIKEKTPKRFSISTLKPRVFDLIDDKDMFVCKIQKLSEPSGKVLRTLQCKLIKDEYGRDVFVCNDVTDVSDENGNVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUR6</accession>
    <name>A0ABM5JUR6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501686.1">
        <property type="nucleotide sequence ID" value="XM_050645729.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645729.1">
        <property type="protein sequence ID" value="XP_050501686.1"/>
        <property type="gene ID" value="LOC126881441"/>
    </dbReference>
    <dbReference type="GeneID" id="126881441"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="431" mass="50197" checksum="68085D382ECA05B4" modified="2025-10-08" version="1">MELREDYIKTNQNVLILSIKSELEECMFESNYTKDSLSDSYCPDDIKIEEHVLQCEIGSPFPVIKQEVKTEIKELDEQNLQVNHGSETRFKNTKELDSEKAVKLHIGASTEIDHEKHGRSMKTSKSLSNIGKKSLRQNEVKTKSEKALVTHNGEKRYKCEICSKPFPSPSHLKKHLRIHTGEKPYKCEICFKRFTQAGTLKKHLKVHTGEKPYKCEICSKQFTHDGDLKRHLRIHTGEKPYNCEICSKTFPSPSHLKKHLRIHTGEKPYKCEICSKQFSQKASLKQHYNKHTGEKPYKCEICFKQFSQEGSLKKHLRVHTEENPYKCETCSKDFTQVGDLKRHLRIHTGEKPYKCEICFKQFTSTSHVKEHLRVHTGEKPYKCEICFKQFSEAGTLKKHLRVHTGEKPHMCKICFKQFSQAGNLKRHLTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JV70</accession>
    <name>A0ABM5JV70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501836.1">
        <property type="nucleotide sequence ID" value="XM_050645879.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645879.1">
        <property type="protein sequence ID" value="XP_050501836.1"/>
        <property type="gene ID" value="LOC126881550"/>
    </dbReference>
    <dbReference type="GeneID" id="126881550"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="433" mass="51260" checksum="AFD943D26DD39E78" modified="2025-10-08" version="1">MAAKIEIKKESEEYDQNDTELSTSADLEDVKNEPGDDYPDYLQEEDIMEIMKTTTDEVLSPEDEYSSRDTDETALNISMKPKTAQESYICQICFKQYTRSTNLKRHLKSHGKNPLKCELCFKRFSRLEDVKQHMSLHTGEKPHKCEICFRHFSRLDYLKLHMKVHSGEKPYECQICFKRFLREEYMKQHIRSHTGEKPYKCEICLKGFSQQGHMKQHMKSHTGEKPHKCEICLKQFAEARNLRTHLRLHTGEKPYKCEICFQQFTQLANLNQHMISSHTGEKLRKCEICSKRFRQAADLETHFRVHTEEKPHKCEICFKQFSLASNLKTHLKVHTGEKPYQCEICFKQFPHRWYLKTHLRVHTGEKPHKCEICLKQFSELGTLKKHLRLHTGEKPHTGEKPHKCKICFKQFAHARSLRRHLTIHTVTNDTETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWZ2</accession>
    <name>A0ABM5JWZ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050502457.1">
        <property type="nucleotide sequence ID" value="XM_050646500.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646500.1">
        <property type="protein sequence ID" value="XP_050502457.1"/>
        <property type="gene ID" value="LOC114339301"/>
    </dbReference>
    <dbReference type="GeneID" id="114339301"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="485" mass="55138" checksum="9DE430582407F2BC" modified="2025-10-08" version="1">MTSTSKSYCSVPQCSSYWNPQISLHRFPLDENMRKLWQSVLRIGKPITKGMTVCSLHFTENDYFPITPQTKLKRLKKNAVPSAKLPQRSHEVICRKRKAPRERIDTESNSPIILNQDPVPAKISAASHYDPEPGCSTSHYDPEPGCSTSHYDPEPGCSTSQYDPESGCSLTTPQNIFKSYDKSTQTASCKEKSKYNLLPFINTDKKMVAFTGVNIDTFELICMCVLNTVSDNGIVVKNLQVEVLLVLMKLKLNLSFICISTLLDIQLNNCRKIFYRMAQVLSSALECAIYWATKEEIVENLPICFNKFKNTRVILDCTEIPVQKSKSLQYRIKTYSHYKKTHTIKTLIGITPSGLISYLSPCYGGRASDKRIFLNEKVLLKLDPNDAVMADKGFLIEKECQEHLVKLIRPPFLKKKQQLSKQESVQTAEIARARVHVERAIQRIKVFKIMKEQIGTYLLPYCDDILKIICAIINISSPILSKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYR9</accession>
    <name>A0ABM5JYR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503073.1">
        <property type="nucleotide sequence ID" value="XM_050647116.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503074.1">
        <property type="nucleotide sequence ID" value="XM_050647117.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503075.1">
        <property type="nucleotide sequence ID" value="XM_050647118.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647116.1">
        <property type="protein sequence ID" value="XP_050503073.1"/>
        <property type="gene ID" value="LOC126882276"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647117.1">
        <property type="protein sequence ID" value="XP_050503074.1"/>
        <property type="gene ID" value="LOC126882276"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647118.1">
        <property type="protein sequence ID" value="XP_050503075.1"/>
        <property type="gene ID" value="LOC126882276"/>
    </dbReference>
    <dbReference type="GeneID" id="126882276"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="529" mass="60367" checksum="87C8EF529D89F981" modified="2025-10-08" version="1">MDSDYHWLITIGLVTSSVIAVTANFFLLFIFCRRRGLRTVPNRFIINLLVTNLLSSILLIPLLLVDQETYSSIQPQNVNKTYREFDKVIITEEFKSDPTSDTIELVSATDIVSEKVLPMDNSGTNALCYFAQSTTSFICTASIFSILLIGINQYFGVIHSLRYHFYINRCRSSIFIGISWFVALFCAILSSLTYSDSSVWHFCKNRPQPSDSVRILNTFYAFTYFFLVILAPFVAICIIYVCIYTAAHQNSERMRRSASAPLNPQIDCTIPVQVKESSQDRLKELLPKVHSAPNFSTLDNEKGFIVEEVKDKKVSRTPSDRSSSSFISNLKHKISNASVFRYREETRAAKISIIVIFLVLVCYVPYGITLVLCSKCIEVNTNQIFNYLSLILLVFSNIISPFLFGYRNKRVKREICKMFNLSKQNQNLDIVDRPRRQSTVKNYSFEYIPETLENDKNDNISSENNRVIPEVVVTCKPENERKSILKRVCNTSNWPSYKKCNFITVPDSCISGEARGSFSSASTQMSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ47</accession>
    <name>A0ABM5JZ47_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503216.1">
        <property type="nucleotide sequence ID" value="XM_050647259.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647259.1">
        <property type="protein sequence ID" value="XP_050503216.1"/>
        <property type="gene ID" value="LOC114338158"/>
    </dbReference>
    <dbReference type="GeneID" id="114338158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045468459" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12897" checksum="582EC20754864AF3" modified="2025-10-08" version="1">MMTFRISKMCNIRTTLLLLTTIIYSIKSTESGAVQLTAQNINNTLEAAKVVMGKVDCEKERSLFSKYKIKKYPTLIAISNGPPEKREKYTGERTVEALTTFIKKQMMEVKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K007</accession>
    <name>A0ABM5K007_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="4 14">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 14">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 14">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12922"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="4 14"/>
    <dbReference type="RefSeq" id="XP_050503524.1">
        <property type="nucleotide sequence ID" value="XM_050647567.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647567.1">
        <property type="protein sequence ID" value="XP_050503524.1"/>
        <property type="gene ID" value="LOC126882591"/>
    </dbReference>
    <dbReference type="GeneID" id="126882591"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 14" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="93"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="459" mass="50949" checksum="B09D289DD6996A6E" modified="2025-10-08" version="1">MPCPFLSKLNTAYVQTYAVLLLQLYSKHCPVISRILSTAAKNDDDFFDYDHFFNQQIIKKKKEHSYRVFKTINRLAGPGEFPTAIEYSYKHAEIIVWCSNDYLGMSSHPEVKAAAREALELYGTGAGGTRNISGNSLLHEQLEHRLAQLHNKDSALLFTSCFVANDSTLCTIAQALPKCQIFSDSGNHSSMIRGIINSRVPKHIFRHNDPVHLKHLLESVDRSIPKIVVFETVHSMSGDVVPLEEFCDISHKYGALTFVDEVHAVGLYGEHGAGIGERYGVMHKMDIISGTLGKAFGTMGGYIASTTALVDMVRSYAPGFIFTTALPPAVVVGALKSIDILSSQEGANLRQQHQSNVKYLRNLLIDKGFPVEPTSSHMIPIKIKNPIKCSAICDILLKEKGHYIQAINYPTVAKGEEQLRLAPTPHHSKELMERLVEDLNNVWLFLGLSLVDQSNNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0D3</accession>
    <name>A0ABM5K0D3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503644.1">
        <property type="nucleotide sequence ID" value="XM_050647687.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647687.1">
        <property type="protein sequence ID" value="XP_050503644.1"/>
        <property type="gene ID" value="LOC126882706"/>
    </dbReference>
    <dbReference type="GeneID" id="126882706"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="45795" checksum="49E9787FA666B6D8" modified="2025-10-08" version="1">MDTEDHIHMKFIKPFLAIAGIWPLDIKGFKLLMYNFYFYATFTYYVLNVSTIYVTAKQVASHGTPTEITNYISNAVFSTLLIYKALTYRSSGIKDLLNLIKRVEADIVNEEDEEIKTIYMKNVKASEYFGKVYVYQAIVSTFCAQLFPLISTLMSKPNEEGYKEKYYIVANWEPFDKYEYYGVAYLVQLAFTIYAEMYIIFCGTFLLFIMDNIVGRIFVLQYKFSKCFDNAQVLCETHGMSFKDACNILVTGCIREHQQIIWFMNNMDNTFKRYIFVEYICTSFGLSVVVLQFLLEESIQMKIAAAGFFIVFASQSLIIYYHADIVAFEGSHGLVKAIFSSNWHILDVSAQKLLKFVILRAQKPLTLSIGPFRKVGVESMIALFKATYSYLSVMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0S6</accession>
    <name>A0ABM5K0S6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503789.1">
        <property type="nucleotide sequence ID" value="XM_050647832.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647832.1">
        <property type="protein sequence ID" value="XP_050503789.1"/>
        <property type="gene ID" value="LOC114340365"/>
    </dbReference>
    <dbReference type="GeneID" id="114340365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046334479" evidence="2">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="349" mass="38383" checksum="5446FC6E5752D78F" modified="2025-10-08" version="1">MLKLRGILIISSLCFLLANGITRSDTYIQNSGIEDLETSASGYSYQARSGTPFNYKSFSSESDGIPYEFDQPSDSIGRYSNQPIPLNLLPLSPNFVPNYDSKSVDSYGEMLAPYAKGYEHFVDENFAKPNHHERQSTNFIKGGGSNYEDGVSASSGEKGTKGYSNRDEFAKGLKGRHQNDQRKGFYDVLGGDKRGHQEQEGHYSTKHHSAKGNKGGSFSEESSHDKGSKTTGYHKVYHKDEYKKDKSFYDKQDKKGHFNRYGNFNAKAGSDAGIVINGKSVDAGFRQGEFGAKGLSEKGRFLDEASGYRGANGDASHYRNDAAYANKAGKSRGSEGGYSETKGDYAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K144</accession>
    <name>A0ABM5K144_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503909.1">
        <property type="nucleotide sequence ID" value="XM_050647952.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647952.1">
        <property type="protein sequence ID" value="XP_050503909.1"/>
        <property type="gene ID" value="LOC126882887"/>
    </dbReference>
    <dbReference type="GeneID" id="126882887"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="264" mass="30540" checksum="996766431E320C1B" modified="2025-10-08" version="1">MEWNEENTQNLLEMYHERPVLWNSRLADYKDRNKRRDALLEISVSFGVEKEEIEKKIRYLLSHFAREVKKEKDSEKSGNGTVETYKSKWFAYKLMEFLKDKNKPIVTQDSEGKRKRKEEDSQEVETDDGEESLQVLEQSIDGSENEVGTTAQSQSKSNSINIVKSRGRKSMATNLPIVNEAVNLMRSITAKRAEKDEFSLFGEQVAMKLRKIVSPFARFSVQNIINTVLFEAEMGKYDNPHFINHSHPSTPQAYPLQSFNVAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K242</accession>
    <name>A0ABM5K242_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504258.1">
        <property type="nucleotide sequence ID" value="XM_050648301.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648301.1">
        <property type="protein sequence ID" value="XP_050504258.1"/>
        <property type="gene ID" value="LOC126883076"/>
    </dbReference>
    <dbReference type="GeneID" id="126883076"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19489">
        <property type="entry name" value="Rad51D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047323">
        <property type="entry name" value="Rad51D_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="77"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="309" mass="35329" checksum="3655626A8FD69F71" modified="2025-10-08" version="1">MEYLSSSLHDNLSCNILKLLNEAEISTVIQFLNSESKKIEKVTGLTLREVLDIRKKLLKLYSKPISAYDCYQNIISNFALIPTGIERLDILLEGGLFTGNIYEICGLPASGKTLFCLTVLKNIATKANSDIVYLDTKYDFLGTKLKQMLTNLNREEIISSMNRIQVLRVTTKSEFLKYLLFIKHSVDNGKPIKLVIIDSLPPLCFISSDQTENNAFLCYTANILHYLAKEHNMVIIVTNLITLWNEGDFKNIDVMKERISCGTYWFEMPNVRICLKKDKYNCRMTLTKAIKVIPEVNFCDVKFTDEGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3V2</accession>
    <name>A0ABM5K3V2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050504867.1">
        <property type="nucleotide sequence ID" value="XM_050648910.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648910.1">
        <property type="protein sequence ID" value="XP_050504867.1"/>
        <property type="gene ID" value="LOC126883385"/>
    </dbReference>
    <dbReference type="GeneID" id="126883385"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044978072" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="467" mass="53293" checksum="6D0C8C38AD62972F" modified="2025-10-08" version="1">MMFRAVAATFLLLCYIQDAEVAFSSFYPKLKPKNIKRDVIVTEDPLILTPYIENNQIEKAQSLAKVPSDVFKNVKSYSGFFTVDKAFDSNMFFWFFPAETNYKEAPVLLWLQGGPGASSLYAIFQENGPFNYNNSPDLELNPYSWNKEHSVLYIDNPVQTGYSFTNNGFAQNETKVGEDLYEAIRQFFLLFPDLQKNDFFITGESYAGKYIPAAAYAIYTKNKEAELKINLKGMAIGNGLCDPVHQLVYSDYLYQIGLADSNEKEEIHHLEKEIIQYIHKEDFQKAFELFDDLLNGDLNGGNTLFKNITGFTSYYNYLQDHGSGESNLTDFLESEQVRKAIHVGNLKYNDGDDVEKKLVLDLMQSVAPWISELLSNIRVLFYNGQLDIIVAYPTTENFLKHLHFSAANEYKTARRQKWYVGDYLAGYVKQAGNLTEVLVRNAGHLVPGDQPKAALDLITRFTQNQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4S3</accession>
    <name>A0ABM5K4S3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505187.1">
        <property type="nucleotide sequence ID" value="XM_050649230.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649230.1">
        <property type="protein sequence ID" value="XP_050505187.1"/>
        <property type="gene ID" value="LOC114334389"/>
    </dbReference>
    <dbReference type="GeneID" id="114334389"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="439"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="519" mass="59837" checksum="5A108EFBAF1A6354" modified="2025-10-08" version="1">MKNINTTALELAQQLHTANALSANTERLFSSTYEYPANSSIRKEKVKQLKNQLVRQQSVLLQVSDKTKATTLASYKVSQVIAKKKKPFEDGEYIKECFVEAANCLSEGFKNKYEIMSAINSLQLSARTVTRRVENMSEDVSQMKTDLQRFIFFSLQFDESIDISDTSQLAIFVRMIFDDFTAKEELVKIIPLKGRTRGEDIFSSVQDYFISENIALQKLVGITTGGAPAFTGVHNGFIALCRKDDTFPNFLTSCISKHFVRRQFRTLIAEMNLEYGELLLHTEIRWLSKGKILRRFYELLPALIAFLKERKEDYSTLEEPAWLRDFGFLTDVTGKLNELNLQLQEVIEKEVVNVQPYTGEGHIEMLTRPRHEFDTRFSDFNKIEAIAQFVSYPYMPLDAESLSQTIEQHFSEIRPETELEIVTLQNDLCLKSVAGKENFWCLVSKQKYPILVNVALKINALFCSTYLCESTFSNMKFIKNKYRSRLTDEHLDSCIRLRITNHQPNVKKLTDMMDCQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K512</accession>
    <name>A0ABM5K512_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505272.1">
        <property type="nucleotide sequence ID" value="XM_050649315.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649315.1">
        <property type="protein sequence ID" value="XP_050505272.1"/>
        <property type="gene ID" value="LOC126883659"/>
    </dbReference>
    <dbReference type="GeneID" id="126883659"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35646" checksum="B24D72934AB90971" modified="2025-10-08" version="1">MAENEAGSHVLANMATVSAPSEFNFSLPGSWNQWKKRLERYMSVSGFINKPEAEKIDMLVYLMGAEAEEIMTQFNLTPAQQVYSIIIEKFDAHFIPQKNVIFERFKFNTRSQQPGESVDAYITALHSLAEHCSYGALKDELIRDRIVVGVLDVKVSERLQLQKNLTLGEAVLTVRQAELQNSQNRILRQERVQEVATVNAHRGNYWSQSQAEPNKYGQQNTWGKSNKNYKCTYCSVPSCNSRERCPAKDSRCRLCGKKGHWQARCRSGRNVRVVEGQNCAESEVGIENEMENLQVNNFDFHLGHIYTNDKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6H2</accession>
    <name>A0ABM5K6H2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505785.1">
        <property type="nucleotide sequence ID" value="XM_050649828.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649828.1">
        <property type="protein sequence ID" value="XP_050505785.1"/>
        <property type="gene ID" value="LOC126884040"/>
    </dbReference>
    <dbReference type="GeneID" id="126884040"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1498" mass="172790" checksum="263F52F7F46AF8EE" modified="2025-10-08" version="1">MQCFLCKHLSAQTKDFKGIQDKVKEFSNKTWLSCTTSLKARQQHQHQWNDVELPENWDNNEIGYHSQCYKKFIVKKQFLLPESETPSTSVGATISSVDEADNLKTNSSNLSTSWLVCEAAVSYLSTEDYSTNSSFSSAAINLEPVNVSVKCTRQQLSRDADDIENADEMEVDNDIVDDSIVENEQKCQEKCFFCGNISIKWKGRKLYCSQTKHKIRFFDRIRSYATEMNDVEMLMSIHEEVNNENIMLFYHQRCSLKYFSNFKAYTNKPPTTIWTDTRGYNEIARKQLIQYIEKEVVSESKIFSVTYLQDIYILFLQEVYESEGKDFPENLITTNTLRQYMEIHLKKKIKFEYFSKKWFVMSVNTDLENINDDEILDIIFEQECREFAIKYRKKILQIKKKPLPDFLDAEALNKGECDIPNWLNVFWKTALSGTKVETERIERLTACLASDSIYSITKGNIKPRKQIIFGMSMKSLTGNVKVMEILNRCGYSISYSGLAELESSAAYSCIANGQTCPSGIIPTSSLACGVAWDNYDRFVETQSGKNTLHDTVGIAYQDIPAANHLIAQESHNSSNVQEQNLALNLRNKSNRRKRSFESFETENLPPTKQKRPEFISNNKESASTNPTTTVSLESTNTDPPTSNEELFINEDNTQGVETSSTSDNEKCVLLFKQINFCWIFSHKLHLQNVPMWVGYNAKISNDNSTIQKIDYLTQINDSPTDPRVIKETMRLSLKIASECGKKYFNVTYDLAIAKIALKIQSAEEEFKNLFIHLGSFHIMLSFFKAVGKFINGCGLTNMLVDAEVLANGSINTFLTGKHFNRCCKIHPIISLALQLLHVEFFLENKQYDLETIKTYLKHYSENENENPVINNELCHKIFEDYAQFKKDTLQGNHGKTPQIFMMYIQLIDYYLMLEFSIRTANFDIYKYVLEKMTNIFFAFNHQNYARYLTIYLNKLEKIEETHPGLIQEYGDCFFGIRRTTKPFSRNPIDITLEQTINAHAASRSSGIINMTNSVGARQKWAITHSLRTNMISKLMDFCNLYSKDDITKDLRKSSICHSNKNVENLLTIIQQCTNPFSSNLSQENLYNISSGQSVSEDIYTFLSNIETTGELQRIKFITESQIDPERFDKAILKNTVVNFASKCVKKVKINGKVKEVTIQRDIFGRLLYASLQSHIDLKEALKYPLTPIPFSLCHSDGSICKTQKSVIFEELKSYQEENGNPPKADIHIYDGFYLLHTLKNVPNTYGKISMYIFKLLVSDKKEVHIIFDKFNDPSIKDYEHRQRGEDDTVHSVHKNNKRPSDFGKLLRSKNFKESFVEFLIDDWTDDCFVILCQDKIVKLSYGTSCYSYQVHENHIKKTTDYNLCCFHEEADTKIMYHICQLPNNYNVEVHCTDSDIPVIILANMKYLKADIQITVNMCSNKKREYLNMNKIYQGLGDKLARALTVCHIFTGNDFNPAFYRKGKKRPFAILKKKTIVSRCFYAATRNGAEIFGYRTRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K791</accession>
    <name>A0ABM5K791_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506059.1">
        <property type="nucleotide sequence ID" value="XM_050650102.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650102.1">
        <property type="protein sequence ID" value="XP_050506059.1"/>
        <property type="gene ID" value="LOC126884213"/>
    </dbReference>
    <dbReference type="GeneID" id="126884213"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="542" mass="63669" checksum="471650C9C6EC128C" modified="2025-10-08" version="1">MSTMEFKEEIKEEFIEGDPSYIENQLSTSIDLEHFKNESENNSEMGLKARIKEDFAKGSLGYIESQPSPFADLEEVINKPNEDNSGFSQNGMDIMKTEVACPTEQKISADAEETILKKSVCECKICFKQFNHACSLRRHIKIHSGEKPFKCEICLKQFSRAHHLKTHLKVHTREASYKCEICFKQFSLKRNLKTHLKIHTEEKSYKCEFCFREFIRATSLKYHLKVHTGEKPYDCEICSKQFIQASDLKTHLRVHTGEKPYKCEICFKQFSQTSNLKTHLRVHTGEKPYKCEICFKEFNQTSSFKTHLRTHTGQKTCECEICFKQFIKASELKSHLRVHTGEKPYKCEICFKQFSQTSNLKTHLKMHTGEKPYKCEICFKQFIQAIGLKTHLRVHTGEKPYKCKICFKQFIRARELKVHFRVHPGEAPYKCEICFKEFSQTSNLKTHLKVHTGEKPYKCEICFKKFSQAISLKTHLQVHTGEKPYKCEICLKRCHTTNDLKRHLRVHTREKPYKCEICFKQFRHTNILKTHLQVHTGEKPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA78</accession>
    <name>A0ABM5KA78_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fanconi anemia group I protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507093.1">
        <property type="nucleotide sequence ID" value="XM_050651136.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651136.1">
        <property type="protein sequence ID" value="XP_050507093.1"/>
        <property type="gene ID" value="LOC114328229"/>
    </dbReference>
    <dbReference type="GeneID" id="114328229"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029310">
        <property type="entry name" value="FANCI_HD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029313">
        <property type="entry name" value="FANCI_S3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029314">
        <property type="entry name" value="FANCI_S4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14679">
        <property type="entry name" value="FANCI_HD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF14677">
        <property type="entry name" value="FANCI_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14678">
        <property type="entry name" value="FANCI_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="373"/>
        </location>
    </feature>
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            <begin position="382"/>
            <end position="530"/>
        </location>
    </feature>
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            <begin position="553"/>
            <end position="778"/>
        </location>
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            <begin position="824"/>
            <end position="1032"/>
        </location>
    </feature>
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        <location>
            <begin position="1055"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="808"/>
        </location>
    </feature>
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        <location>
            <begin position="1311"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF14678"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF14679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1360" mass="154361" checksum="C1135BB01454C9B3" modified="2025-10-08" version="1">MSSLIEKIYELGEKCDKDGLEKLISDLDDDELVGIVKQNLCSSNFTECWSYILKAFKDKSDDHDKRIYLACKLLNELETRDLPQTRIDTIMNRLNLELPKFKSKDLAKLCSLCLEQVQSKKTIKFAWKDFLPEVLNVLIERETFTYEELDYTGAEYKSDFVNTICMSSWSPSIVTTLTTVFVEMPLTKEEHLKIVNKLGTYIGKLIPQEIPAFVYQLLRLCKNQNGKSIFLKLQSYFGLRIYNNANAQAESSPDSMSLDIIESSDNNDATEAESTVLYHIHTAASIGYECIKEYLNFLKNMVRAPEFVLHPFQLMVLFTISTISLYEETVFEIVRPAIVKSLNEQQRKIRSAWFRDIISVASKPEDVLLQVVQFSLQDRDLVLSGLVNFAFVLLEVGSALGRDVIAEKQWSLGNTILLKIIKRKRLIALTILQKLGDHIVTRQSVTQYIECLYILSRSMPLLMIENQSCIIELIECLVQVSPHVADQLLDALIPLMKVSPTIRDHMIVYLRKALYSRSVETRQMAVNGFLKLIKNLKISNMAVLSQSQNSMGSFSSGHSVFTQISLNKTTQGVTPGSFSNEALCFEILSILRRCFMQQADVRVKLYEGFFDAVCVNPELGIPVLDVIWFHLIKYYIMDESQALPLDFSKIVVVKEAQVVLDEPLGKLIHTIGLIVTKVSEMEEEKENNTLLKYTNVLDSLATRLSTCELVHFELDDGTNLLDIVPESQRKLFTLREAMSTYEALLGYKIYSWNKSSEKQGNIVNGLYQGYSRLYHFAKSLSNPKKADGKRKKVDTDKTTQSSQAAALKKESQKLNKNLKIPDTIWNFPVVKKALSLLHEPKLTWTTVTEANTVKTKKELHQHVMQATLYLVQQVKRRKDLETLTKKTYFDHVTYVASIIFKRIIKRLEEFVDFDSLTAALALECFGIILNLVNAQYKSNLKSFLSKVVSEEDSNTEDMITSLNSIVEIYQKIFERGEEELADDLEQRKLSLIAITTLNSLISHVPETSSILSVQMLEWLKNYAYNNTLSSKNSSCFINLFFETNIKYTVLQSLTLLENMSVSIGDTFGVITEEEHTIEKIKIVNEGTVNNILLSLCGCIKTILDDVDSVIARLKSEYIILSYPGEDDTTNRREKLKTKEQGVCTQLCFVVTILTNVTNLLLPPGNLAEAVFKSIVQLFGTLSSLTKYFNSRSSKINLAFQGARFERLVKLAGKQLAPTIYKFLLHLDDAQKEATQATQSTKKKSTDSSVLKSRVLRETRLIPKVVYEMEQFSKCIIQLSNKTKVDLSKYVGQGTARDFRILTDALNKDMENVDESTAEHDETATSHDDSRTSQDGSKNDETVESDSSSDSEVPPSKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAE1</accession>
    <name>A0ABM5KAE1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450 4C1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507152.1">
        <property type="nucleotide sequence ID" value="XM_050651195.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651195.1">
        <property type="protein sequence ID" value="XP_050507152.1"/>
        <property type="gene ID" value="LOC114332503"/>
    </dbReference>
    <dbReference type="GeneID" id="114332503"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64456" checksum="85B156E235A1698C" modified="2025-10-08" version="1">MNSGDRTSEISPDLVLMNTLQIKASSSGAVSVFRHVYKQGRTQDRFSGGAMTSFGEGYRGVWRFLALLVVFITSLVAKFYWSRRHLYAAAAKIQGPKGLPIVGNALSFFCDSEDILEKIKIIFEPVKHEPFRFWLGPYLLIALKNPVHLEKIMSSQKFAYKHDLYEFLEKIGGDGLITASGLKPKYKIHRRLLQPMFDLNFVRSTLPIMNERFKLCMEELEKFTNGKTFDIVHVMEPCSMGVIAEIVMGQKLNSQSIYNIQLSQVMSKLLYCGFTRMLKLWLHSDFVYNFHPLKKEQDDALSTLHHFINEAITDSCTRRKFNKTNTFIPVLDKLTEIVERNSEILSREDLVDHLTNILSASQDPFSIISCFSIICFGMYPEYQAKAVEEIKNVIGEKQREITLEDIYKLKYLDMCVKDVLRLFPIAPIILRRSIEDYHLDKWTIPKSAAIAIPIYFLHRDPEYWIHPDHFYPDHFLPEFVQKRHPYTYMPFSAGPRGCIGKTLANIEIKLFMAMFLQTYKVEADGNVPLLKLCADISTRAKFGYNCRIKKRNGDIKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBL3</accession>
    <name>A0ABM5KBL3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507580.1">
        <property type="nucleotide sequence ID" value="XM_050651623.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651623.1">
        <property type="protein sequence ID" value="XP_050507580.1"/>
        <property type="gene ID" value="LOC114336641"/>
    </dbReference>
    <dbReference type="GeneID" id="114336641"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057847">
        <property type="entry name" value="ZMIZ1/ZMIZ2_GBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25527">
        <property type="entry name" value="GBD-like_ZMIZ1_ZMIZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="631"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="836"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="980" mass="104839" checksum="F7EAD9D890F81602" modified="2025-10-08" version="1">MLGYTSYRDWTGPGAGAQQQLSVVTTVWGVSTTTQSGPHGGAYTGGPTPTANPNYIGAQGTAGKVQQGGYQGGYRQSVPPGVSGYGAGNVMNGSDQGYGSGNALSTAAMVAAATATATATASVVALQDNSQFNNQQYQQGYQQRMMGMNGMNGMSPMGMNMGGMHNNMMSSMGPKMGMQGPGPGPNSSSMYPRRMTPYPSPAMHMNQKRGTQQSYPNTCPTMNPSMNPSMSPMNPSMTPSMSPSMNPSMNPSMNPSMNPSMNPSMNPSMNPSMNPSMNPSMNPSMNPSMNPNMNPNMNPSMNPSMAASMNPNFNPSGQYPYNSTRQPNFNQYPSQQTLGPTGNFGPGPGTMMSMGNPRQMRQATPPYTNQGQYFNGGSISQFPSNNSGQYMSSNANSSSQYGSTSSAQFQQDVAMRNNMNYQHSPIPGNPTPPLTPASSMPPYISPNPDVKPNFNDLKPPLPMQNDELRLTFPVRDGIILPPFRLEHNLAVSNHVFQLKPTVHQTLMWRQDLELQLKCFHHEDRQMNTNWPASVQVSVNATPLIIDRGENKTSHKPLYLKDVCQPGRNTIQITVSACCCSHLFVLQLVHRPSVRSVLQGLLRKRLLTADHCIAKIKRNFSNTGSSATGNGDRDAVEQTALKVSVKCPITFKRITLPARGHECKHIQCFDLESYLQLNCERGAWRCPVCNKPAQLEGLEVDQYMWGILNTLSTQEVEEVTIDSSANWKAAKGNMPGIKMEDEGNDSCSGGKRNKAMSPGSMTLPTMNNWDMQAMSPYLPPDMNSIASGSMMNGGPPSYNNTYSSTNEYLSGNGPLSHLSESVNSLDPLNAMEKSLNEQMPHTPHTPHTPHTPHTPGGGTPGSAHTPGGGTTGPPSVPPPSTDTHNTSSGSNNGGPGSVSGSGTNADTSVPEIPSDLNFDPAAVIDGEGTGQEALNLLPDSVDPMELLSYLDPPDLNTPPSSGSSSGQANTSTNDDILALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCG7</accession>
    <name>A0ABM5KCG7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507884.1">
        <property type="nucleotide sequence ID" value="XM_050651927.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651927.1">
        <property type="protein sequence ID" value="XP_050507884.1"/>
        <property type="gene ID" value="LOC126885368"/>
    </dbReference>
    <dbReference type="GeneID" id="126885368"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046569226" evidence="9">
        <location>
            <begin position="18"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="598" mass="69845" checksum="7EA20424E41B7AF3" modified="2025-10-08" version="1">MFVLIAPLFLILSSAEAILNIDPLTDLSTEQSLSSCAAELCRFYFRDQFNESVIVIFENSTNFSPLRSFLVNELANKNKPCYIIFLNKSILRSKSTRVFKHLLIEISSVDKFKETIEMIKVLPSWNPKANFLIISFTAFEDSKVTSNIIFTILWKEAIVPMAVILIDQKNLTNFNIFTRSSMYDLNIDISELNICRRFRGENITYDKIVTKKMDTFKKVRVKFFPWPPFSMYDGQPGIEIRLIETLAKTCKLTVEYYEIDPRYPSGEVFANGTLTKEFKELSDNKFDIIFGGYKLTYGRILYLSPSISYYYDELLWCVPSKKYYQVNIYIQKMVILLSLLILLVLIVLIWYTNRSEEPKLRFDASIDGIVVKAFAICLHIAITRLPRTGRLRYFVGLLVIFAFFCNIMFTTKITSFFIKREPCQMYDSMSKIYQHNLKTYFVTNSLRYFSNDFIEGISRDEIVKKKIDCHDSLECLKFIQEGLSAFLTTKSNTEYFLNTKQVDKESIYCFHYSYGSSISLIMRKGFLYINEFNTIIHQLLSAGVVQKWKQEIFSVNNKDQKELEVEKLKLQDIVVIFYILIFGCICSCLVFLCEIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KED2</accession>
    <name>A0ABM5KED2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508518.1">
        <property type="nucleotide sequence ID" value="XM_050652561.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652561.1">
        <property type="protein sequence ID" value="XP_050508518.1"/>
        <property type="gene ID" value="LOC126885821"/>
    </dbReference>
    <dbReference type="GeneID" id="126885821"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="131" mass="15307" checksum="42B4A2F0CD6191BC" modified="2025-10-08" version="1">MLQSFPVDKIAIQKLLDLHCMDGTGREREYKNMKHLIMNVYVCDPQKIIRKRALKSQGSCKMFIWCTSRIIVSKNIETDCCAVTYFKTHYGHDDDIEHLHKYQNQINISSKFILRLSSKIKLQTVQDSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEH9</accession>
    <name>A0ABM5KEH9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508568.1">
        <property type="nucleotide sequence ID" value="XM_050652611.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652611.1">
        <property type="protein sequence ID" value="XP_050508568.1"/>
        <property type="gene ID" value="LOC114328666"/>
    </dbReference>
    <dbReference type="GeneID" id="114328666"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="504" mass="59014" checksum="C2675265CAEED241" modified="2025-10-08" version="1">MEAAEDIKDFKVEIKEEQEEYDLESSKSISQLSTEIEIEDVKNETKDESGFSQNGMEIMKTKLACPTEQQNATTEETTVKNSTCKCKICFKQFHYKSSLNRHIKTHSSEKPYKCDICLKQFTAKSDLKIHLRVHTGEKPYRCEICFKQFSRAGHLKVHLRVHTGERPHKCEICFKQFSEAGDLKRHLRVHTGEKPYKCEICFNQFRRTGHLKVHLRVHTGEKPHECEICFKQFTRASHLKVHLRLHTGEKPYQCEVCFKQFTHKISLDEHTKGHTGEKPHKGSPPSRSSFSLGFSQNGMEIMKTELACPTLQQNATTEETTVKNATCKCKICFKQFNYIGSLKRHIKTHTKERLYKCDICLKRFSQKHNLKTHSRVHNGEKPYGCEICFKQFTQAHDLKRHLRVHTGESPYKCDICLKQFTRASHLKVHLRVHTGEKPYKCKFCFKQFVQKSQVERHLRVHTGERPYKCEICFRLFIQAYDLKLHLKVHTGELPYKCEICFKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEN1</accession>
    <name>A0ABM5KEN1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508649.1">
        <property type="nucleotide sequence ID" value="XM_050652692.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652692.1">
        <property type="protein sequence ID" value="XP_050508649.1"/>
        <property type="gene ID" value="LOC126885900"/>
    </dbReference>
    <dbReference type="GeneID" id="126885900"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="176" mass="20063" checksum="1ABFAC8179640140" modified="2025-10-08" version="1">MIDMCLYFIVFWKETTFLPPGVSTTLKSPAIQQRGPCHQGCNHITKTATTNIRRPGGIQHLQPQSPLQNQQQYHTTSRRYLQLPKAISIIQNFFWKETTFLPPGVSTTLKSPAIQQRGPCHQGCNHITKTATTNIRRPGGIQHLQPQSPLQNQQQYHTTSRRYHQLPKAISIIQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFV4</accession>
    <name>A0ABM5KFV4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCAN domain-containing protein 3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509070.1">
        <property type="nucleotide sequence ID" value="XM_050653113.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653113.1">
        <property type="protein sequence ID" value="XP_050509070.1"/>
        <property type="gene ID" value="LOC126886248"/>
    </dbReference>
    <dbReference type="GeneID" id="126886248"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF22">
        <property type="entry name" value="SCAN BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13627" checksum="786915ABC2A8D857" modified="2025-10-08" version="1">MAAFVKDANPEMSLLYCDIHRKHLVAKNISHVLNGVLHSVIKCVNAIKANAKCEPVFNLFCEEYNEDHNMRILLNTDVRWLSNGNCLKTFMELFDILSDFLSDKPETNMYQQSIIKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIU7</accession>
    <name>A0ABM5KIU7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510135.1">
        <property type="nucleotide sequence ID" value="XM_050654178.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654178.1">
        <property type="protein sequence ID" value="XP_050510135.1"/>
        <property type="gene ID" value="LOC126886973"/>
    </dbReference>
    <dbReference type="GeneID" id="126886973"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053084">
        <property type="entry name" value="AKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025663">
        <property type="entry name" value="AKAP_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14469">
        <property type="entry name" value="AKAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="359" mass="40819" checksum="A5B8A36DB49E53ED" modified="2025-10-08" version="1">MEIPSLRSSVSSDQHELKRKSLLGSGSNKRVSIDEKSTIVHLVYDKSLQDVVDPRALCTADLTVEADSKDDIHSQFTLNNTNDYKTVYVKSLPEIQSIETDSKLESLIETETESLRSDQIEVHIVLKEILQGILSTVSGRMVETPKPPPRSKSILMPCFEFTCEFKRKERQAICSPYKDLEILTEEFVDCIISEATAEVEKHLTAYTSQKVKKHMRLEIDDEIHPSIMKPVFSWPTIKQFNIALGLQKITEFIMACDAKERWLFGVYYLRTTREAISAFYEYEVICGLPSSIYPIAQATASIYFVIEVSNVIPSTCSVTVFFQFEANKSVYNAETTGLNETALIHILKSKIKIYSSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKC1</accession>
    <name>A0ABM5KKC1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510651.1">
        <property type="nucleotide sequence ID" value="XM_050654694.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050510651.1"/>
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            <taxon>Insecta</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Cucujiformia</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
    <sequence length="3479" mass="390934" checksum="1B0784B4E1E92FEA" modified="2025-10-08" version="1">MVESERKCSAEIHLADNALPIPIQIFLWKQVGPFVRPKLGKLHEASCMFCQHASTGHHELKEACKSFEKVLVQNIKSGLKPDLTDAIKSIPRWRLIQASLPHVMHAVASILYNRMKDGNIQNLGAVETKLLYTLHWIILDAMEECADEDFEQGIFHLSPFYYLFSIPTITLFVYIFAPICHNLKESDFQNFRLENGLKIWQAMWEFRHPDAPCFVSHCKPKPKFLNGKNLKYKQQFGDVFVGRKQSQDEPLTRDSPTSQGISASSSDQQHFPLPGPVTCGAPVTITATITTKVDDEGSWVSSPKDTVFPETIPEESSSTEEEHVVIFRLPSLNESDGFIRDPSIYTAETSIIQLAMRRNGSGRTVNNVKPEHISPGDPKAGTKPPMQKVGSSTDKDSLDSSKLPSTEAPAKEDMTKMAMHVYDSSAATFLDVAVLRCLFITLWQEEGIYWALHYMYNRLRDINDESVGQQQPRKRSNSLPIPKIEVSLYQSNDSRKGENGNKDFIEVPEPRDVSLLTDAFPESPFYNQSKSEESLHKRSSSEKIGKKRKKISDLKTFVETKLLSKSDKALEKIGQEEQRPLGKSSVGSRRMLNVLQEYHRSLDTGDEHLSRTQTSMSRMFEPPTNLVKGKSMPSLSCILDELNQPGGYVDELTWEVKRVGKFAQSQPMANPIITVTEHTPTPSPDYLRRQGSMDSQLDAASLSGSKLGNWQERKSSLTRSQTDSNITYAGEDVPEAPGATCYITKDGDIDLQVVLQAVHRTSVRESSSCTLRVLEVILNIIELIMDMGVLKQCLKEEAMGSTTNQQDASTPDKKTGKMQQSSTHGSLGITDPDKNKPISSHRLVMNSIIRVLKHLGCPQGCADGQRGPAAEFLRTQSQNILVKLNRASPKQFKSFLKDYVKYEPLTDVMDFFHAYVGFCIDPSSLLSPLNQKRGSSKSQDTVSQSGYGTNFGAGLGGGGIRGIEGTIMSHVFKPLVTRFVDSSKEIKTPESLTLYCEIRQLMTYVKEGHGSIFRRVALSALIDSADKPSKKEVNMQTTRVIRHMHHSEVEEQQDVPTDTQSYTEDRGTRKSLFKKRSTSSTCPSLLETEAEELPKTSQSPIGNIRKKHYILTPRQSERALGIALEPQLSIKAKKSKLGGLVNWFKKGESSSQDELDNVDNGDSFTDTSSFIRQSSKYYQSKESGRSNVSQSIQKAKRRMEDKFKFVLKKGKKKDGSQEESAGGCRRTNFKKSTNIKNIYFVDYSRKNSMEFGDNSRESEFVVLKERKLVSTSTVYQGVCRLSFLLETCPPGSVPDAHLLASVLDLPHATVIARATLLLECAYFVHCCNKNQWPSWMKYNLPVYRPSGPLPARGNSTTGLRRSHIMQRAAGKMFYQWAEVIGQRLEEFMNEDKALHPQVSAMVADEQKQKELLIQDEEEDFLDEASINSYGSSCPMALRLIACVLLQEITAFLRETYQTLPKSSRVMEKGKPAPWEKLYSKEANRRWSMALSSMGHSQTSAQSLQSIAGDRDSGQAGERKISFVLHEPDNESEGSSQTTVTMQQLLQGDDAKRQQQARPSYILRRGTAAPTGGSFKRRSLKLRRGTKEGMDVEWKIPDSVKRTDSIQSKRKVSSISDRSDTSEPGAPGEVSGEESPGVLSDEQPPESPSDSNDTDDTSKHMPWLKTMIQVSNSFYYYCPHQQFCHPFCYRRVMRACSRLIKASRKVYGEEFGILDDKLCMDFGGKKKTKKEKGQNRKVSDQTSSTVSPIRRKDSVGKKEKIDKNVDTSQMGKLFSKDSSRDIADSDTGAESKISSDKKPEEPPPILKYLKTQVKDAFHSPLAVLLKGAVIMTEENFLDIIPVAWELLLEPNQEVTACAASIFILGAVKSPQTVSDIMQHGLSHPDCAIRINAILRFQVLWKMRYQPWPRMEENAQVLFKVPPPGIEFTLPSPKIGIESLDVVDSPWELLVKTKVEEVTINQERHRSLVTATKTRKKQQTELIKMALQAQDDKKREERENFLITTIPITIQAAHEPSLYHTGEEHEEVDDEQVDGQPRNTGHHLHSAHSLFPSCLCSAVVQIINLLDDAAVSADGNAVYEVAYQVIWTCLVEDSALFLRYILERLTREKQELMFKILRHLIRFIPKLPQQAAFALYNYIIGYVMFYVRSPHEDGQKLIGAALSLLWMVVHSVHGIMFKDLKQILRKEQCDASILLTANVPSAKKIIVHGPQDPDAGGIPSQFPVQEDTQFCQILREALDFFGIEESKHKEFFLVDYKTHQIRNPSSYVRDYYFFKRSQYPQLELVHMKPDVAFNALQKQELLHKFVEIGKVLLTWAILKNVDMVVQRVVFLHEELMKLPSFPRKALESDLDLYKSGPLGKELLGLDVLHKFMWVRLIARMFEAMAGNFAYSGDIHLFVNVLNGALVLHSEDACILRYVTATYINAAFHFKNIFSTNGYLLIMPTLLKIYSNHQTNQLVTTTIEYAVKQFYLMNRKPFILQMFGSVSAMLDTDEDGTYGDAHKIQSSCLFNLLLSLETPSPDPLNIAELVKEDKPLKAIDFCYHDENEMVTILDCISMCVMVVSYSSESVRGYQMLIILEAILPCYVRQIQYPTYNKEGKKEKDIINQLAVAIKTLVNNCESLTKSYNGPHRSSPEHKGSSQRNYSRGPYSPGFDFEDDSHSKFMSEHSRAKSMYEHDVEDSEVLRAEYRRPRDVLLSLVGEFVCKASIRLQELNKKSNNDGKVVELLDIRSHVRLADIAHTLLKVSPYDPESMGCRGLQHYMTYILPSTDWSNDAMRPALVTILRRLDKVFQKISKKTSIRRNTDWDAAAGLLKGIYDTMVKYPYIIHWSQIKALISTCQSLVVSGDNCQSEGMTSATAALLRQAPPPHFCSMVVRLIALQIQNMQDTSTLEQVCGGSSLFPSQEKTESMIINLIMPLCLRVGSGRKDVGQMKQADISFALTLVLHAMSPPNTKSLNPSGPNVKPTAENRTGSLTFTGTRDVKLSAKIKTSLYQVAFLALKIMAICFEGELMNEWSKIGRTMRELGKRNEAATFVWDFLDFVVTHRTVLYILMQPFIFQKLAQPPISDFERNMHSKIRNKMHSIGLPLPKGRGALLMELAHEMKLLKEEIENSRENLFDTKKDSAPTCQMTTEVHSTRTQRPSLIGLLTGEGHHGKSAGTHDIMHSHLKESSSTSHTSTPVQSSHINEGQEPNANGHSTPGAQPDRSSQRSSVSDDHGVPMPKSESLMFHKAHKLRFVSSVEFRHSSGETSTTPLSPGSPAEDSSGEIYPNKPRLQRIKPQSRKTFRIRKSKKTRQAEVAQAKHESESILGPQHQDSLSPPPTPPVITQSLQESQQSQSQTTPPKADLSQSQKFEPISDSHRLRIATRNKMAEGSWDEDSAISQTSSTSGYRESYPVMHLKETLESSPKAFPPLASPDIHSLPSTSSATTTNNFLLMDNSSPDCSLNENGEKTALLGPSEKSSSHQSLLMVFDAQDENTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLL0</accession>
    <name>A0ABM5KLL0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511038.1">
        <property type="nucleotide sequence ID" value="XM_050655081.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655081.1">
        <property type="protein sequence ID" value="XP_050511038.1"/>
        <property type="gene ID" value="LOC126887491"/>
    </dbReference>
    <dbReference type="GeneID" id="126887491"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="798" mass="94907" checksum="DC63B405A016AE5A" modified="2025-10-08" version="1">MEVKVEVKEELEEYDERYVTSQLSTEVRLPDVKDEPNKYTPESGNKDHSKEENRTKIMKIHLPHKEEEYISGHSEEKTLNKNTETHLKIHAKERTYKCEICDKQFTKKRYLNAHVRLHSGKRPYKCENCDKRFARKNNLNLHMRVHTGERPYECETCLKRFRQRSTLNNHMTVHTEEKRYKCLICPKQFAIKRSLNLHTRVHTGERPYECDTCFKRFSQCSNLNNHMIVHTGEGRYKCDICLKQFTKNRDLNEHIRIHTGEKPYKCDICLKQFRAERYLNSHMRSHTDDRPYKCETCLKRFTCPSALSQHVLVHTGEKPYTCEVCLKQYSQKGALNKHMKVHTGERPYECEICFKRFSERKSLNIHMAVHTGEKPYKCDICLKQFITKSCLNRHMRSHTGERPYMCEICLKRFRLHNTLSRHVLIHTGERPYKCDICLKRFIQIANLNDHMKVHTGERRYECEICFKRFIYHSNLNVHIKVHTGERPYKCELCSKQFRQQSGLNCHMTTHSGEKQYNRSYKCELCSKEFSTKSYLKKHNMSVHVGERPYECEICDKDFTLLSYLKQHMAVHTGDRPYKCEICSKQFTKKSYLNTHMKVHTGERPYKCDICLKQFITKNCLNKHMRSHTGEKPYMCEICLKRFSLHSTLGRHVVIHTGERPYKCKICSNQFTTKSSLNTHMKVHAGERHKCEICLKQFTQQSTLRRHTKAHTEIKPYKCEICLKQFSLQSNLNEHVLVHTVETPYKCEICSKQFTTNGNLNVHMNVHTGKRTYKCEICLKQFPYKSSLNRHVKKIHTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMV7</accession>
    <name>A0ABM5KMV7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511536.1">
        <property type="nucleotide sequence ID" value="XM_050655579.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655579.1">
        <property type="protein sequence ID" value="XP_050511536.1"/>
        <property type="gene ID" value="LOC126887773"/>
    </dbReference>
    <dbReference type="GeneID" id="126887773"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56919" checksum="58B0EAE99B6F11AD" modified="2025-10-08" version="1">MEASTAADAEDDEIIKEIPIIHSKRLEDNLYLFQYPLNHSITTNQHKIKSCFFKPKNQEVKLELGIDTRSPNFDTGRAEIIAHEVDKESDKTKKNPKFFENEVVDKVFLQSSKTVQDANRYAVAVYNGKEVHLTSLSGVFQFRPVFPYMEKGLKRKKETDGNESDEEQPGPSSAQQVTVKFKSSDERWKKLDETSYHALQSKKAEEPWTECEWHEADSTFSCVERLKLMSDNTEDISQATTLGDSDYIRLLIPEDQEQTPLEPVLPSHLLSLNALRALPIQERCRVLLKDAQIIRFQQLLMLLTGGEKTATDSLLKVLPVVAVLVRGNWVVKSDVLYPANTFSATSGVPAELMCRARDYILYQFTKSQYVERKKVSSILKIPSEEIKEIFTGISKLRRHNKEWELHLPTDQDFINKHGDIVQKQNLMWEHRFHQLSQFLKDNMSQRRKSRSESKSVSEDGKVRNSLSFSSDNESDKGKGVGKKNKGGKSGSNQATTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP41</accession>
    <name>A0ABM5KP41_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511956.1">
        <property type="nucleotide sequence ID" value="XM_050655999.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655999.1">
        <property type="protein sequence ID" value="XP_050511956.1"/>
        <property type="gene ID" value="LOC126888007"/>
    </dbReference>
    <dbReference type="GeneID" id="126888007"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="114"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="270" mass="31415" checksum="17DEDBC84E968D85" modified="2025-10-08" version="1">MDENEESFNYTPPEIVKLATATASTLIPETSKSIYNKTYATFNEWRVRNNAKSFSENVLLAYFAELSAKYKPSSLWSFYSMIKSMLRINHDVDLEKYGKLRAFLKRKSEGFQAKKSSTLTPEQIRKFIDKAPDEIYLLHKVILIIGIMGACRSNELYQMNIEDVKDLQTDLLITIPKSKTKIVRKFTINSTFYNIVKKYIDLRPSHVKINSFFLNYQKSKYTIQRIGKNKFADIGRQIAKYLNLPNPQSYTGHCYRRSSATLYILMEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ10</accession>
    <name>A0ABM5KQ10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512272.1">
        <property type="nucleotide sequence ID" value="XM_050656315.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656315.1">
        <property type="protein sequence ID" value="XP_050512272.1"/>
        <property type="gene ID" value="LOC114328060"/>
    </dbReference>
    <dbReference type="GeneID" id="114328060"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF71">
        <property type="entry name" value="DYNEIN, AXONEMAL, HEAVY CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1399"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2029"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2870"/>
            <end position="2918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3228"/>
            <end position="3255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="4081" mass="469421" checksum="61E997D593A3BC02" modified="2025-10-08" version="1">MESKHQKYGPRLIPTDPWLPDAKLEGETEPNYILERVKKQNEYPPIFAKKSWTKAVLEKDIQMYFKPTETIGATFTPGAQELRIQDLPKRKKKVNPSPLGEDGKLRYPPKKSRKQIEQEELLLEQHAKKVDTSAFVDIIDLLSGDYHRRKESEKIAKQKELKMKRKTEALKMEGYSYEKERGQLKLLQAILPKDPDDQKRFLYKECHIEMNKMIKERDIERMIYYLTEGIGTEYISPYDDKLLLRVRAKIPEKYKLLKDFRVMVTTDEKIVKKLYCIYMRKHLLQYVLKDPAEWIRLRFQTFPSEYPIMLVRAPVPWHTNYCLSTQLMEKHYYNGNIIVRKIRDLWWEKYDNMLIVPQDDLLNKDLTSLTPAGLEERVVAICKNARNIIVNQWLPSCADIFLEFRNYWRQYIPKIPSDTTMLVERFFDCVNVLLSMQLRWLVEKSLIHFKDLFIQFKEGNEYGEKYEDLKLINIPILTLTVKPHVGTDQLIFSPTFDEIQALLKRCFAKILEVNRKIYRIEIIMFPEFATKERFLHHVHRKEMPVLALQQEIIDSFIPNAIGPQKYLSVYDKYLYILDGTAEKELTDFFEIPPFPFLKDFARKIKHYDELKVEFINLRKLIPMNLFNLDCAELNETLYNIIETLRMKIVNYFIAECRSLNRLICDTFDEMSQKASGNPDTVAEIVELQAYVIECRDVTMYNLREKIRKTAEYVLFLMDYAHLSNDDIQLNTRVFLWPKDMELVIEIAIQRLNMKRDQAETTLKNRRTAFDARLRRHEKMLIAFKKKDPPILTMEEMEESVGAVEIIVQRLAEDKAEAEQINEEEQLLDMDPSPFMNLYKMLQVVDPYDKLWHTVYDFHKNYDLWYYGPFQGLDADEITDYTEDCWRTLYKLSKTFSDNPGAKRIAEMVRAKVEKFKQFLPVLQTICNKGLQKRHWDKISEIVGVPLAITEDSTLSDMIDAGLPKFTTQLEEINAGATKEHALQVNLAKMKEEWVEIRFELTPYRETGVNILTAVDDIQVMMDDHILKAQTMRGSPYVKAFEDEMAAWEEKLLSMQDILEQWLICQATWMYLEPIFGSEDIMRQMPTEARNFKLVDRVWRAIQNNTMKDTRVLIATDYKNMLTLLRENNKMLDEIQKGLNDYLEKKRLFFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIHQLEFTRDEEVIGMISVEREKVPLSEKIVPADAKGMVEKWLVQVERVMIQSIKDVMRDSIHNYPVVDRPTWILNWPGQIVQCVDCIMWTTEVTDAIFGGALEQQEHLCTHQIEQSVKMVQGKLRANTQVTVEALIVIDVHGRDIVKMLKELKVTSVADFNWIAQLRYYWRDLMVSVCMITTEVMYGFEYLGNTGRLVATPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETCKDLAKAVAKKCVVFNCSDGLDYKALGKFFKGLAQAGAWACFDEFNRIELEVLSVVAQQILSIQMAVAAKLTKFVFEGTEITLDPTCTVFITMNPGYAGRQELPDNLKVLFRTVAMMVPDYAMIGAISLYSYGFVQANSLSEKIVHTYKLCSEQLSSQNHYDYGMRAVKSVLLAAGALKRMYPDVSEPQIVLRAIIDVNLPKFLAQDVPLFEGIYSDLFPGVEIPKFERAELIECLESEIYKRNLQPTPWFVDKCMQIYEMILVRHGLMIVGRPMGGKTSAYQSLAAGLGTLANRQNASLKEYDVIYKIINPKALTMGQLYGQFDPASHEWSDGVLATTFREYANSTTRDRKWILFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQMNLIFEPADLEHASPATVSRCGMIYMEPALLGWKPFMDSYMNKLAKFLLVEQQELLVECMEWLVPAVFKQVHKSKRFVETSDIHLYFSFTRLFTCLIRDENQVSTVWLQCTLIFCLLWGFGSTLTLEGRQTFDTFYRKLLYGENRKYPKPKSFKLTKSQIFPDRANVFEWVYDKKNNGTWISWTDTVEKIDKIPPTAKANELIIQTNESCCQRFFLKMCLDNKIPILFIGPTGTGKSAVVMDYMLNLPKEKFLPNIVNFSARTSSTLTQEMVMSKLDKRRRGVFGPSMGKQCILFVDDVGMPQKETWGAQPAVELLRQYIDHGHWYEKDTSMLYLVDILFVGAMGVPGGGRNEVTDRFLRHMQIITIDSFDDNTLSKIYTTILDWHFAKGYVEPVARLSKFCCAATSEVYKEAIQQFLPTPAKSHYTFSLRDFSRVILGLLLTPPQRMDDPDKFIRLWIHETYRVYHDRLIDDDDRKKLFNIVKEACYQGFRQKFDKVCAVFVPEDEIIAPRHLRNLFYGNYINPDADPKIYDEILDMEDLIAKMEYYLEEHNTMSKTPMNLVMFQFAIEHVSRVSRVITQPNGNALLVGVGGSGRHSSAKLAAFMAECAIFEIEITRTYSTSEWREDLKKLLTKAGTEGKPILFLFADTQIADEGFIEDINTILNTGDVPNLYAPDEKAEILEKMQAVLKESAKKMEATPLALYNFFIERVRRNLHIALCLSPIGDSFRIRCRMFPSLINCCTIDWFQKWPDDALERVAHMFLSQTDIGAEMIDVCVSICKHFHVTVQDYSDIFYTEQRRKTYITATAYLELIQTFISLYALKVGQITLQQRRYETGLEKLDFAAGQVGLMQDELTALQPKLIIASEKTEKLMVKIEQDTVVVEKQKEIVAADEAVANEAAAAAQAIKDDCESDLSEAIPALEAAIEALDTLKPADITVVKSMKSPPSGVKLVMEAICVMKQIKPERKPDVATGKMIEDYWGPSVKLLGDMKFLENLKSYDKDNIPPAVMKRIRDRYMPDREFNPERIRHISTACEGLCKWVRAMEVYDRVIKIVAPKKARLAVAEAELAAQMDTLNAKRAQLKEVADKLQALNDEFAAETKKKKDLEDDIYICAQKLDRAEKLIGGLGGEKARWSATAKECEALLGNVIGDVILSSGAIAYLGPFTVNYRQSLLKEWNEYALKSGIPCSSNFSLVVTMGEPVVIRAWNIAGLPVDNYSIENGIISTTARRWPLMIDPQGQSNKWIKNMEKTNRLQVIKLTDANYVRVVENSVTFGTPVLLENISQEIDAILDPVLVKTIFKSQGVWYLKLGDNVLEYSFDFRLYITTRLRNPHYLPEIAVKVTLVNFMITPQGLQDQLLGIVVAKEKPELEEKKNMMIVESANNKKMLKEIEDKILEVLSTSEGNILEDETAIKILSSSKILSEEIQEKQKQAAITEKEIDTARNGYLPVSKHSSVLFFCISDLANIDPMYQYSLVWFINLYIHAIDVSPKSFILDERLAALNDYFTNSIYRNVCRSLFEKDKLVFSMVLSVGILRSHGDINEDIWNFFLTGGVALDNPHANPSPDWLSDKSWSEIVRASNLKGLNNFMASVKKDNTAWKKFYDSSNPNELPCPAPFNHVKGLLRLVLIRCVRPDKVVPAVQNYVVEEMGPSYLEPPQFNLEESYHDSNPCSPLIFILSPGADPMAGLVRFAADRGISKTSLMTVSLGQGQGPIASNMISTGLETGQWVVLQNCHLAESWMRELDRICDEVIIPEVTHQNFRLWLTSYPSKAFPVSILQNGVKMTNEAPKGLRQNLLRSYYSDPISNPEFFGACTNQKAFRPLLFALCFFHGIVQERRKFGPLGWNIPYEFNESDLRISVIQLQMFLIDYTDVPYDALTYLTGECNYGGRVTDDKDRRLLNSLLSIFYIPETVKHPGYAFSPSGMYYVPTNNTWEGCLEYIRSLPINALPEVFGLHENADITKDNQETQALLHGILLTQTMITAGGAAEDTQAQVIDLANDILDRIPSIFDIEYADEKYPVMYTNSMNTVLKQELIRFNRLIVVVKKSLRDMIKAVQGLVVMSPELEQTCEALVVGKVPEVWASKSYPSLKPLGSYVNDLIARLKFLQNWIDNGEPNVYWISGFYFTQSFLTGVLQNVARKKKLPIDWIHFEYYVTEYEPDNTDVTCPFGVYCKGLFLEGARWDRKLRRLNESFPKILFDLIPIMWMKPAEISKFSPPQCYYCPVYKTSARRGILSTTGHSTNFVMYITLNSNVPEKHWINRGVASLCQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQB1</accession>
    <name>A0ABM5KQB1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine-protein phosphatase non-receptor type 13-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512374.1">
        <property type="nucleotide sequence ID" value="XM_050656417.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512378.1">
        <property type="nucleotide sequence ID" value="XM_050656421.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656417.1">
        <property type="protein sequence ID" value="XP_050512374.1"/>
        <property type="gene ID" value="LOC114328744"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656421.1">
        <property type="protein sequence ID" value="XP_050512378.1"/>
        <property type="gene ID" value="LOC114328744"/>
    </dbReference>
    <dbReference type="GeneID" id="114328744"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF12">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="3">
        <location>
            <begin position="390"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="922"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1184" mass="134243" checksum="1D6E096183CCC3EC" modified="2025-10-08" version="1">MSRLRNNSNSSHGPYGGPSLGDFLTSRPSGLQESESWAILCQAVQALQDLFLSDGAFGSSCIPVVTPQSLLFSSRGRVKLCPSTLLCDGKLSTHLMGYLAPEYIPRKRFTDTELEKMWIYALGETLKRATLTSHVAASRLSAELCQTFTDMTHPQASSRASLMHLLDVISSYCKTKQQHRPFSHIVMDLHQETMSALEVAMDAAWGPPAMPELQPRTINWTDTNSENFGTIPRRWMGLSRNHDSCLPKITKEASTSMEDLSFTRQLFHVPGTVVRPKSMYVADSDRPNSEINVISDNIFFNKHLSEQKFESETVSKGLASGTTNNKGINTRRLKVRRNPVQRAASRLYRVNSKKHIGDTPRECVGPEFVVRASLLSKQLTMPDVKTSSGRTLTIIMLNGQKLDVLCHPSSTTAGQLFELIIQKEHIEENFMFGLSALISGDFVFLPSDTRISKIFQEELQQGTPITLFMRVRFFLPTLRGFRGNESRHLLYLQLRRSIIEHQLPCSFKQIVELNGLALQAEFGNYNTREHGQRDYFLLEHYIPESMSSAIENTEKLRQELIQAHVLKHGMDGDKAEESFISLAQSLPHYGGHFYTATWIMKDGNHKDIWLYISAQGMNMYERGKNTSHYGPHLYEKFEWRNIQTLCYSKQYLCILPHSNYESVSKLKKYKLKMDQKKSYFTFRLASLHHQFFLRFRTDYISPHTLSQQFGVPLKDMKNEANSMYKLDSIMNSNLNQNKNGTVNADTEFKIEFIQSSPRLRRYVPDENRLKKAKSIGDFNETINENDQNKENENNGFGLVLESKHLSGLTVSSTDKRRGVKMGTRAFVNNSKSGLSRSMEAVNAISNEYLEEMSLQSVSLHCSSTSASRPTTGKCTPNEIFVLDSTLKQTSQLFLPNFQETISESLQEKLNNFSFVEERMLFNVSLQRENGSFGLQITEGSDGNVYIQSVIEGGPAHLKANVQRGDQIIAVNKKSLLGLKYNEALDILKSAGQEIQFVLARNSQNLTKTKSVSSILSKNELQLGHSYLCDSPVEKHVTESCRDISNVSKYGRLSSQTEVPYHKHIRYKIEPETDSFMSNKDFPTRPSLSRSLSKSCTNLYSSDNDKAIVVEMIPKEHIDLSNINSLDRKTLREDMTKVPIAMPRSLGVSRRWRGPVKYPVTPIKKLSQLNDSTYLSTSDEEQVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQD6</accession>
    <name>A0ABM5KQD6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512399.1">
        <property type="nucleotide sequence ID" value="XM_050656442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512400.1">
        <property type="nucleotide sequence ID" value="XM_050656443.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656442.1">
        <property type="protein sequence ID" value="XP_050512399.1"/>
        <property type="gene ID" value="LOC114330100"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656443.1">
        <property type="protein sequence ID" value="XP_050512400.1"/>
        <property type="gene ID" value="LOC114330100"/>
    </dbReference>
    <dbReference type="GeneID" id="114330100"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028512" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17348" checksum="552367BF491E013A" modified="2025-10-08" version="1">MNIKILLSLFFSPFCVVSPGINADQVDPRWLKNEDFHKFHEQCNREYGVEGKDPQSIPKDVADGIKLCYSKKVGLVTKDNYINRDVIQEMKDVEKDNLELAENIDKCVTDEKLTNETITQKIKCLAEAYLTHGLAYKVTQILAIRLLPSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRS1</accession>
    <name>A0ABM5KRS1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512884.1">
        <property type="nucleotide sequence ID" value="XM_050656927.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656927.1">
        <property type="protein sequence ID" value="XP_050512884.1"/>
        <property type="gene ID" value="LOC126888578"/>
    </dbReference>
    <dbReference type="GeneID" id="126888578"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="323"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="859" mass="97297" checksum="065FA8BFBE8C5624" modified="2025-10-08" version="1">MEQGQINKLTRSKTASKLDLTRLCSSVETDLASLTKYMIKEILCQLRDAFRTYNDATNLLAAELATTEDVDPIVKKYYKCISLLEEKLESLLTPPTSSTTSEISSVPNPNVPSPSSQITQNATTKQRTVKLPELRINNFSGKLKSPESQTADENLSQIVQKFWESEEVNPPISESVENHPSELLFLNTVKILPSGRYQVNLNLKHSVDDLHMGNSFITAKKRFFHLEKKLHSDPVLLQSYSKIIQDYHSQGLVSDVPLQVRNFDGKFNYFLPHFPIIKTSSTTPVRIVFDPNNKSTSGICLNQVLDKGFTVQPELFDILITFRHYTYILAADIKHMFLQISINEQETFLLNFLWRDKQDDKLQCFRFNRLPFGLSSSPFLATRVLKHIADTHAISHPSAAKTLLNSTYMDDVLSGGNNLEEIETLHFQLSSLLSKHGFQLHKLSSNHPEFLKKHKLIPTPEIKLSLAGSSDKILGIIWSPDQDTFSFKPPVCEVTSPITKRKILSYVSRLFDPLGLLSPTLVYSKLLLQRIWSLSLDWDTPITNDKILSDWQSLLTKFQSINLTKFPRCLVLDKKVILTQLITFCDASQDIYAACVYLRVTYDDSTVSVRLVTSKTKIAPLKNKLTIPRLELSAILLGIQLTHRSQGILQKDLKISETHLFSDSTIALTWVTTSKFLYNQFVQSRVIKIRSLSESYQFHHVESKQNPADLPSRAKSICSNAELTDLWLHGPKFLIKPEIDYSLFQIKKWNGELPELRKNQVSLNVTVTAQSNDTLDDLFNRCSSFTKIQRSLAYVLRFVSNLKAKSNHTAIDTDTILSYIASNGSIDLLEQILHLPGLDPNKPDNEGNTPLHFAAQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS30</accession>
    <name>A0ABM5KS30_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512995.1">
        <property type="nucleotide sequence ID" value="XM_050657038.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657038.1">
        <property type="protein sequence ID" value="XP_050512995.1"/>
        <property type="gene ID" value="LOC114335135"/>
    </dbReference>
    <dbReference type="GeneID" id="114335135"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13680" checksum="038BAC41CF540806" modified="2025-10-08" version="1">MYWNEGASTLRSKCNKYYLSVQVVLVWECEMKESDAFDRNELLIELTDTDKNISYAQYSTFSIGCEKDGYPLKELTGYSGNAGDSLTSHINAKFTTLDVDQDKDPGNCAQKYGKCIFVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KTL5</accession>
    <name>A0ABM5KTL5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513535.1">
        <property type="nucleotide sequence ID" value="XM_050657578.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657578.1">
        <property type="protein sequence ID" value="XP_050513535.1"/>
        <property type="gene ID" value="LOC126889343"/>
    </dbReference>
    <dbReference type="GeneID" id="126889343"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="155" mass="17487" checksum="CCE7AE728999D1EB" modified="2025-10-08" version="1">MSTQIAKAVQFFNVDQFGRATYRMVGNVGKFVPCYYYTFNYQGTLAGVTMRCSPGAQHGEDLSYLFITSERVPTVYDYFIVRRITTLWCNFITTGRPTPGPISDLLPVEWSPVSIINPPVMQIDLNMGFISPPYSNFYSFYGAEIFSLGPSSTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUC3</accession>
    <name>A0ABM5KUC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513786.1">
        <property type="nucleotide sequence ID" value="XM_050657829.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657829.1">
        <property type="protein sequence ID" value="XP_050513786.1"/>
        <property type="gene ID" value="LOC126889494"/>
    </dbReference>
    <dbReference type="GeneID" id="126889494"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39978" checksum="E7129421AFFFE1EB" modified="2025-10-08" version="1">MGPKTILSEGEEKLLANWILSMGRKGFPVNASNLLSTVHKIMKETGRTNFDNKDDWKGDLQFKKLYEVWAEFKNEALLVTNKHKHVTGEDDSNLMEGNEEMSISFSVPTASTSTQNGKQREESVILPNEEQSQNGNSTILQDKSTISLNVSESFLSPDKLENVALYKDKEDQGYVVSTPFKKCLIFPKTPEKEPPKRKRKIFPAVVSTTLYRAHYDNITSKSGPSKQSQIKIKKLAVKRKVISESETSADDVPYCDEDLDASDVENYTIKNIHDGDFVIIKYNGNLYPGKVIKANQEGAEVSSMEKAGYDWKWPEKEDVLFYFYEDIKKIIREPLVKGKRGYYSVPELSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUI3</accession>
    <name>A0ABM5KUI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513850.1">
        <property type="nucleotide sequence ID" value="XM_050657893.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657893.1">
        <property type="protein sequence ID" value="XP_050513850.1"/>
        <property type="gene ID" value="LOC126889539"/>
    </dbReference>
    <dbReference type="GeneID" id="126889539"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046412395" description="Partial AB-hydrolase lipase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="442" mass="49438" checksum="EDBF86269DA92187" modified="2025-10-08" version="1">MFLTKQLFLIFALLYTAKAGIALDEVATNLVDGLKTDASAIQILLNSAVALGIETRGDIFKTLLDLKLENFGTQKRVSATELIQNEGYPVESYYLTTSDGYILNIFRIPYGKSGKKLNKVVYIQHGFLASSDDWVLMGSKRGLAYILADEGYDVWLGNCRGNFYSRNHTQWNPDKDPQFWQFSWHQIGTTDIPAMIDFIIEITGVTKLYHVGHSQGTTSFYVMASMRPEYNAKIAHHISLAPIAYMNHLFSPLVRALALNYLLGSFTLESLSKNEFLPSSGFLNMLTDSVCSEGVGQVLCKNALFALTGFSPNQMNVSDIPLIMANYPAGAATKQLAHYLQLTNSGRFCQYDFAILKNKEHYGQIIPPDYDLSKIAAPLTLIYSSNDWLAAVVDVERLAKQLPNLKESYRVPLVTWNHIDFLFGKDAPTLVYDKVVSILTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUQ1</accession>
    <name>A0ABM5KUQ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 6k1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513917.1">
        <property type="nucleotide sequence ID" value="XM_050657960.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657960.1">
        <property type="protein sequence ID" value="XP_050513917.1"/>
        <property type="gene ID" value="LOC126889575"/>
    </dbReference>
    <dbReference type="GeneID" id="126889575"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="58646" checksum="438B83272B72B2E4" modified="2025-10-08" version="1">MELYRSVQMLLTSSPFLDGLIYLSILCIAAYCYATRDFNYWKRRNVQFLKPVPFFGNLYDVMMFKTTTQECIKKIWDGINAPYFGMFIFDEPVLVLKSPKLIKDVLIKDASTFCNRRVATPSHPNMAHGMFFLKYNEWRKVRKMLSPVFTSGMLRYLQPHTIEINQTMLDFVHKNCGIFDVTNIGEDFAIEFLVRCFYEANPRCFNEKPSVFKKCIHTMFAFNFRNGVVQNLFFLKPALADALKLNFVAKNCMKFFEDVFKRIMTARESYDGKPRSMVDVANKAIREKKRGEKDALGFETIMSNVLLFLIAGRDSTTTIISFTLYEIAKNQEIQDKLRKEVKLNVEKHGSICFEGVQENKYLEMCINETLRKYPTLPFLDRTPIDDYQFKDTDLKVEKNTSILIPLFALNRDEHIYPNATLYNPDRFLSDQINSDGLNFIPFGEGPRICIGKRIGLLAVSMALSTLVLNFSFQTCKDTPKEIEFETKSFALTSKHGLFLDISPIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX33</accession>
    <name>A0ABM5KX33_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514753.1">
        <property type="nucleotide sequence ID" value="XM_050658796.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658796.1">
        <property type="protein sequence ID" value="XP_050514753.1"/>
        <property type="gene ID" value="LOC126889995"/>
    </dbReference>
    <dbReference type="GeneID" id="126889995"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="144"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="453" mass="52288" checksum="0EFBF8FBB27DD84A" modified="2025-10-08" version="1">MEIADHAIIRYIQSIYFKKEILELKNAKLVTNKAIRKLNPFLQHNDGLIRVGGRLRHAPISYNQKHPILLPSKCRVVELILTQAHHKLLHSGAQTVLSYVKMKYWPIDGLRQIKRLIRKCVNCFRFMTPNSVQQMADMHPDRVLPTRPFQVVSVDYGGFFLIKSSHLRKAPLYKAYVAYFICMSTKCVHIELVTGLSAEAYILTLKRFIARRSTPSIIWSDNATNFHGAKNEMREFYDFFLNQNNSEQIKEFCTQNSITFKMGVPRNPHQFGLHEVGIKSVKYHLYRIIGNSHFTFEAFNTVLCQIEAILNSRPITRMSSDANDFAFLSPAHFLVQRSLTAPPEPSVSEIPENRLNLFQRISKIQQQFWKLWKKDYLCLLQQRNKWTDPTDPVKIGDLVLLKEDGTPPLLWPTARVIDVLPGKDGLVRTVKIHTTHGDFLRGITKIAVIPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXI4</accession>
    <name>A0ABM5KXI4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514895.1">
        <property type="nucleotide sequence ID" value="XM_050658938.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658938.1">
        <property type="protein sequence ID" value="XP_050514895.1"/>
        <property type="gene ID" value="LOC126890090"/>
    </dbReference>
    <dbReference type="GeneID" id="126890090"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="228" mass="25885" checksum="5DB09BC872F12478" modified="2025-10-08" version="1">MTRVRSRSPPRSKALSPPRYADSKESLLLQHPEESSDDHSSDQEDGKDGFTIQNRRIRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTRANEEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKPEKKNPEKTDKKPPVEKVSLEKLAVAMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXW2</accession>
    <name>A0ABM5KXW2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515029.1">
        <property type="nucleotide sequence ID" value="XM_050659072.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659072.1">
        <property type="protein sequence ID" value="XP_050515029.1"/>
        <property type="gene ID" value="LOC126890218"/>
    </dbReference>
    <dbReference type="GeneID" id="126890218"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="23664" checksum="AB897861C15383BA" modified="2025-10-08" version="1">MPHVQVSDSEKLRLYKFIENGSNLELAYRSWEYHEIPLLPQTMKFNWNVKTTSLLERPRFVLFALQTAKKNAIKEDASHFDHCNITNLKLFLNSEMYPYDNLNLNFDKKQYAIAYEMYAQFQPSYYYKVGDPCLSLEQFGSFAPIFVIDCSRQNESVKSGSVDMRIEIETNKNIPVNTAAYCIIIHDRIVNYNPLTNVVQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZB5</accession>
    <name>A0ABM5KZB5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease-reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515530.1">
        <property type="nucleotide sequence ID" value="XM_050659573.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515536.1">
        <property type="nucleotide sequence ID" value="XM_050659579.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659573.1">
        <property type="protein sequence ID" value="XP_050515530.1"/>
        <property type="gene ID" value="LOC126890551"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659579.1">
        <property type="protein sequence ID" value="XP_050515536.1"/>
        <property type="gene ID" value="LOC126890551"/>
    </dbReference>
    <dbReference type="GeneID" id="126890551"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF29">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="27568" checksum="B9FD206BD026439C" modified="2025-10-08" version="1">MIMGEIQKEKENNIIVQIDGEKTYSFKRAKEIIYLGAKIDENGHEEGEIKARIAKGNKKYGALRTLLKSKYVSRKTKIRIYKTVIRPTVTYASETWVLKKSETDLLERWERKMQRAIYGGVKIEGQWRRRTNKELEELYQEPTITTTIKAQRIRYLGHIERMGSKRMPKMVLSRRPIQKRRKGRPRKRWKDSVYEDLKKSNIERWKELALDRRRWREVVKECIKRLKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1A6</accession>
    <name>A0ABM5L1A6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516221.1">
        <property type="nucleotide sequence ID" value="XM_050660264.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660264.1">
        <property type="protein sequence ID" value="XP_050516221.1"/>
        <property type="gene ID" value="LOC126891087"/>
    </dbReference>
    <dbReference type="GeneID" id="126891087"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="186"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="619" mass="71039" checksum="161A1A1BE7228287" modified="2025-10-08" version="1">MFRKGLSEDELRRLAEESDFSDSSMSESTFYDSDADPVYNENVTDGSSDSYSSEYESRRKKAKICKQTQNCKEFTAGSSSNQKEADTRRIEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVVSRNKITWSDVPNPDDLNKFELSFTSGINQEELAKLTDHKPIDFYLLFIDRQVQDLLVTETNKYAEQTIIAGIVNESITKHSLMSNWRPIDRKELLRFLALIIWMGLDRKPKLRNYWSNNLLYKNEVSKMCEISRSRFEILLHFFHISDNESCPPGNRLYKISPLVQILNEKFQKMCTPRESLCIDETMVPFRGRLSFLQYIPGKRHKYGVKLFKLCVADGYTYAVKVYGGKEMQPSEKSLASRVVMELMQPLLDTGRSLYTDNFYTSVDLAHDLNNRKTHLVGTLRSNRKHNPKAVVNAKLKRGDMKYLQSNTKVVIGKWKDKRDVLFLTTKDIPLMIDVQTKRGPVPKPSTIVDYNSAKSFIDVSDQKAAYNSPVRRSMKWYRKLAVELLTNTALVNSLVLYKSVTGKHLSITEFREQIVQSLLMPQTTSENSLTTSENSLTTLHTWTRKRKGEGVQHVTRTFRTVKEEHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1H6</accession>
    <name>A0ABM5L1H6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516291.1">
        <property type="nucleotide sequence ID" value="XM_050660334.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660334.1">
        <property type="protein sequence ID" value="XP_050516291.1"/>
        <property type="gene ID" value="LOC126891152"/>
    </dbReference>
    <dbReference type="GeneID" id="126891152"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55737" checksum="BB2F4BF2F2D1690F" modified="2025-10-08" version="1">MRELARILIELKKINPEIKSLFDALQPKYFDNIVQATQIASGYKSSNDSFDAPSYAMNIVNSFKQCCDIAINFVIKKKANYESITAAEAEAQLRTMLHLFTTNWRYEISSQAANNLNLKRWNKITIVPLANDLKIMKDFLIDLSKKAAAELQVNTNKVSAYNTLLETSYCQVLLLNRRRPGELQRMKLDTYLSCTNDKSTYEEFSLITSPSEQILLKTFKRVVIRGKRHRGVPVLFSKDVQSNINLLIRARPNIVPEENIFLFGKPNSRNEISGYKILRKYARLSGAKNPDAISSTRLRKHLATISQLFNMTEADIEQLALFMGHTVGVHRGSYRLPDDVYQTAKLAKLLLVMETGSGESFKGKSLDDIQLNMDENIMTETNEPEDKEYENFQEDVVVVESEKSKPQNVKNAIVTSTTKKRTLVPWTEDQKVFAKRFFAKNIKKRKAPNRRECEDLIEKYPDTFRNKSWLKIKVFIQNQYSRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2A1</accession>
    <name>A0ABM5L2A1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline-rich protein 4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516571.1">
        <property type="nucleotide sequence ID" value="XM_050660614.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660614.1">
        <property type="protein sequence ID" value="XP_050516571.1"/>
        <property type="gene ID" value="LOC114325341"/>
    </dbReference>
    <dbReference type="GeneID" id="114325341"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045351137" description="Proline-rich protein 4-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41154" checksum="4D90AD73EF1C9EDE" modified="2025-10-08" version="1">MPRVLLLLPIFILGECSVDEKKPSTSSVNKRSIPNLLSGEYQTLATGLSAEEWISDGNTNLDESGPWSSNTDWTAPSQEWQPILPPIQEDKYITIYKEQRVPVLVEKNVPVPVIKNVPVPVPVKVLEPYPVEKIIPYPVKVQHKVPIIIHKPVKVERIVKVPVEVKVDAPYPVEVKEPVPVPVYKTVGVPTPVQVPQPYPVIKNVPVPVKVHVQVPKPYPVHKIIPVPVKVAVDRPVAVPVIKPYPVVVEEKEVSVPVPVEKPYPVKVFVDRPVPVRIEKEVQVPVHVADPQPYPVEKIIEVPVEKEVPYPVEVKIERPVPYEVIKQVPYIVFKKVPVPEENILAVPVQSNEKWDTDQTYRSIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3K5</accession>
    <name>A0ABM5L3K5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
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            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518144.1">
        <property type="nucleotide sequence ID" value="XM_050662187.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662187.1">
        <property type="protein sequence ID" value="XP_050518144.1"/>
        <property type="gene ID" value="LOC126892609"/>
    </dbReference>
    <dbReference type="GeneID" id="126892609"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="765" mass="88341" checksum="72C3A18B258F1082" modified="2025-10-08" version="1">MSTLRNNIYLVGVMKNQICGSKLPCKRDVLSVLFYNMRVVNLNLNDSSALVIDEVVVFWKKARIPVQNRSNCILKLKSLYDNVRNLEKSKNRDTERQREKENDFKEALDNLFDIATLNALNEIKIAEDREFLIKQREKGRVGCMLGVDIKLLRKEKRKEERTAAELKRKEDLLENSSCSIGHFEMEDKEHEDSQKKVINQDNSEDDIYFISESQQGPSSNKRGRKTLMTPRLAAALDKCKVSDRDAMHIISAVLEALNIDITEFVLNRSSIKRNREILRKIKYSSIKSVGNDANFIEVHWDSKLLPDITKNEKIDRLPVIAVGLDFEQLLGVPGIASSAGSEVCSAVFHITDEWNLTEKIQAFCFDTTASNTGRIKGAAVLLQQRLGRDILWLPCRHHIFEVVLAGVFTRTKAIVTSGPEIAQFKALKENWKNIDKMKFLDYTSDEAVYNALKDVAPEIIYFVKQKLAEEQPRDDYKEFLQLTLIFLGDKTNVSFRAPGAYHLARWMAKAIYCLKLFLFRDQMKMRKDNSKLNAEICVFVVYCYVEAWFSATNTTGAPLNDIYFLRKLVIFKNINENIATIAITKFLNHLWYLSKECAAMAIFDDRIERVEKIRMAQKIMECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L935</accession>
    <name>A0ABM5L935_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518952.1">
        <property type="nucleotide sequence ID" value="XM_050662995.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662995.1">
        <property type="protein sequence ID" value="XP_050518952.1"/>
        <property type="gene ID" value="LOC126893055"/>
    </dbReference>
    <dbReference type="GeneID" id="126893055"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="449" mass="50992" checksum="322FE49112FED185" modified="2025-10-08" version="1">MEFKAAINSMQMSGNLYENWRFFIQRFKNYLQATELTKKPEITQCAQLLQLIGDEGFKIYNTFKFSTEEKDKLELLIKKFEAHFKPKSNVSNARYCLFTRKQEEGESVDKFITDIINKAKNCELENLEDSLIKPCITCGVADKTMRQRLLEEDEMSLEKAINLCKSIESSKIQSEKMKSEEVHYIKKRNFNKKYENREQWEDRRVNPTHSKSQDGQFNGKSGSSSGCSRCGMEHRGQPCKAYKAKCLVNTKNSSFDDDFMINFEVNKSKLSCRLDTGAMANCGRKHEKGDCPASRWKCYGCSKVGHVKRLCPNKKNSSTIGVVEESESDSVFQCNELNEDLWKLNMLKDEASAAPHKLKLLLNGELYIDFEVDTGACNDMVPIAKTPNSDEQDKGNLIQVKSPSIQTEAHPSSSLSQAVSGDCAVNSPGTETSLRRSSRIGKKRVRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9G8</accession>
    <name>A0ABM5L9G8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519079.1">
        <property type="nucleotide sequence ID" value="XM_050663122.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663122.1">
        <property type="protein sequence ID" value="XP_050519079.1"/>
        <property type="gene ID" value="LOC126893171"/>
    </dbReference>
    <dbReference type="GeneID" id="126893171"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="43"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="579" mass="65993" checksum="62A8A17E40D6F66B" modified="2025-10-08" version="1">MNKNVKCQKWKCFYNFSTMTDGDNKLYENGIGDAWDSFHNWLYCICVVTFDLELGQALENVFPRHVNLTKQEISNVCYLAFPDSNSGCMGDTNFIIRLQNNQGTKNLRNEHHNYNAKCPTALQVDGSYYWGYVYFRQVKDVSLPRGYFQKSVVILSFLPFNNLFSKLCGFIAPEYFDNGDVTLEAVCYNIERWPPPRPGSTLNLPLLGSVFQTYIPLSTSANSTLALLSEPGDNQIQTNVEDINLFEILQPVLSYIHLLWELVIVSEPIVVMASSPTHCSSMVLALTRLICPLQYCGDYRPYFTIHDSEFKQFTSKSQGPPPVILGVTNPFFGKTLHHWPHTIHLSDDIGQAQKYKLKKTAPTKMIDNSPGVFTAYKPFLQKDKNIIKKLLSGVTSKRPFEVQSAILRRHLLELTQSFMIPLERYIASLMPLQKSIHPFKAPPSPLPFNPDSFFATLEAAGPQLTLNNTGIRGDWVGLYKKFFRSPNFTAWFNTRYTELTMKLQALQTEALSNADLKLWAQERPEVEIVDMVLRIQNKIQKCDQRDIPVDSAIKEKLSLRLNEITSGLPDDLKNILHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYW0</accession>
    <name>A0A6P7EYW0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Piezo-type mechanosensitive ion channel component isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114324805</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128454.1">
        <property type="nucleotide sequence ID" value="XM_028272653.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7EYW0">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272653.2">
        <property type="protein sequence ID" value="XP_028128454.1"/>
        <property type="gene ID" value="LOC114324805"/>
    </dbReference>
    <dbReference type="GeneID" id="114324805"/>
    <dbReference type="KEGG" id="dvv:114324805"/>
    <dbReference type="InParanoid" id="A0A6P7EYW0"/>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="671"/>
            <end position="688"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="1190"/>
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            <begin position="1871"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
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            <dbReference type="Pfam" id="PF15917"/>
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            <dbReference type="Pfam" id="PF23188"/>
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    <evidence type="ECO:0000259" key="16">
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            <dbReference type="Pfam" id="PF24871"/>
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            <dbReference type="Pfam" id="PF24874"/>
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    <evidence type="ECO:0000313" key="18">
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            <dbReference type="EnsemblMetazoa" id="XP_028128454.1"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028128454.1"/>
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    </evidence>
    <sequence length="2538" mass="294989" checksum="E7C778F5216FCF92" modified="2020-12-02" version="1">MVRYVLNVFLFRLLLPVIITLCILFRPCLFSFIYLLYMFLIPFLPVPSSTTLTGSTGIFLKVTLGITGLLTLVQTAFQIALVVAKPYAQFLDDSPTTEDILFYIGLVKLNNLSVAYILVWIGPEFLMMITLLAVFFALRKINPVEEVVVQSETGTVDITLKPQQKTDYTQYFVAVGRYVTLIMLCLAGILRPSVEGGVYYLLFLAMATWWACYKQLKRGFAIVLRCLIPFVLLHLCALYIINFKYIQTYLPEDGPYARYFDLAPFVTTTLTSGTLPSNVTDTLNVNITMPIISHNNSTSTIHKSTNLTMDSDDRSLLYFFHREVTFYVYPVILYLLFFLLVLESNELLKPEPIRKSGVPFPSADSRLSRKVSSRLSKQKLLTPTAAQKWQKASRKVRMALKKELAEATESTPLLRGPTRRSKRSPGRVFQDSTGSVTVTGENEDIPMDVFGTVSFSEEEEEEYDYTLFHNIIFALDAIMQYVVRSSYIATNIIMMAWSITYLSWITFVLLLWANLIWLIPNQRKRMLMSSPFLVLYALFLLLSTYIYSLRLTDDELPSSVDLDEIGFKKPEGPAFIPLLVKSLYTVMFWITLRQYMHEKMEQKQTSALADMVAPLQVTVGTATGVKKEQETGGSKFMTKLGQFINHFLIKFWIWVVAITLFAVAITGSRMTVFRILYMTLFLFFILSFQFSFRAWRKVMFGFWLTVIIYSMIILILIYTYQFKRFPSYWASYLHIQEEQQHDIGLEQYKTKQLFVRLVTPTFFVIVTVIQLHYFHNDFMKLTDPKRTPPPKSPKTDPDKPESDVVRNESLEESSMQGGAYMDRSRESTSKYYSEQDLTIVPSVIMAKWYEKLLKAFLYTKHVFFLFLEIHMLKIVLFFAMLMCIYDKAALYFIIVLLTTFSFTFGRSVQMFTTYFTSVFVSALILGRMIYQISYINEKSWDVNCTFHNTKDINETTVNNGPWLGFGKLSEIDQNLPGIVRWNIIFIVIMTLWKVVEVRQFNYRLSRDRSTERRFFMFPRITRDDADKDLRHFAKYMANYGFYKFGVEISFILMVVLIGVRMDLYSLLHSMWLLILFAMPRRILSQVWLIYLVFIAISIPFQYFHAVGLPPSLCIEYPWSVRDLILRRLQEWAFLLDNFEPPPVRKLVFDVMLLMAVARQWVVFRIERRYAGKDYAGGSNESIIHHAEEKDFVNPVPDYITFVRSYLDICKKAILQSFLWITLAVVFWAGTSRTNIFSLGYLLCAFIFLWHGSDFYLRPIPKILRYWQALLGFNVAVIFFKCAFQILGCIYPTYIPNNLCWLIQIFGITCVRNYSTVVPPKSIIEILDDKTDCTIPSEGITWDVICFIMLILQKRLFNSYNFFHIVDDTKATAILASRGAELMEEMRQKTMKEQEEIEKRVLEKIREKMERIKANQQKIQGDSLVSDNHFIDSISTGRHTQYKIKPPVTYKQAIRSGDYYMFDEIEDDDIDLLPEEQKSLDEFDVGLTPYLGELFNTIVREDINKALLHRTHTMRESRHSIMLHRQTSMPVDRRSDRPHLASTFSAPPTIAEHEPKSVRIQDEPQPSTSQERDEDFSSLTEPKATIGQKIFEILYLVWAFIDGILISLTRFLNKYSRNYRVILKVLAKEKKILKEQTNYNIGVRMGTDQIWQPAGSYNSLLRNSRKSDQAAQLSPYIDPGDEMSSVDQPTIFRFLLACWYLIMSRSEIVCYFVIFFNQLRNSNLISLPLPLMVFFWGSLTIPRPSKTFWVTIIAYTEVVVLLKLVFQFDIMPGNRMREHTEFLTSVSESNPFYPPVLIGLHKTKDMQAVWDLLLLLVVFFHRVLLKSMGIWSSTAPVTAALIPDGDYKVDDEQLIPLDDNMEEDDEIKSDESQPSTSTPKSKSVTRRSAEQEDVVVIKSERLRKIHNAVMAIRMGLGKYAEELKLFIQQLLDPTSRVTADVYSFMFLCDFINFFVILFGFNAFGTQQDGSVSDYLKDNKVPPLFLFMLIFQFMLIIIDRGIYLRKNILGKIIFQFLQIIILHVWLFILFPIITKSACNTLLPPQIYYIAKCSYLLLSAYQIRCGYPTRILGNFLCKGYGYINMFLFKGFMLVPFLFELRTCMDWMWTETSMAIFDWIKLEDIFQHIFLLKCSRNVEDEFPQPRAQEKSRTVKYFMGGALLAVIIGIIWFPLVFFSLGDAVGDPNIPSDVALEVRIGPYEPIYKMTVQANSIFQFNENQLVELKKIYNAYQVSENFIFKYEAVDIAAIKLNTDSANIWSISPPDRQRMLAEINSTKPLKVRLEYKITHKTSKAEDSGIITNAREIQLEASTPTKINEDRENLLRMLRNETAEPVLFPYLLPKFIKVTDRGTADPISVLMLDKPDHRAMEFRNLSIRLLRDNEGNLEQAWWKVNEMCGDPNYENFLDKIPLNDCKQSVILYTFNDKVFPPTLNILTQGGILAMYAAYVYLFYTLLHGAFIWINNIWLDDMPNVDRLYNLCLEIYLVRDMKCYDMEEYLYAKLIFIMRSRELCIKVTRMEGDRYNPIFVMPGSSSRRMIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F115</accession>
    <name>A0A6P7F115_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114325205</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129006.1">
        <property type="nucleotide sequence ID" value="XM_028273205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F115"/>
    <dbReference type="FunCoup" id="A0A6P7F115">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273205.1">
        <property type="protein sequence ID" value="XP_028129006.1"/>
        <property type="gene ID" value="LOC114325205"/>
    </dbReference>
    <dbReference type="GeneID" id="114325205"/>
    <dbReference type="KEGG" id="dvv:114325205"/>
    <dbReference type="InParanoid" id="A0A6P7F115"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF22">
        <property type="entry name" value="GH21596P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028129006.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19006" checksum="627B8A8B27A04D32" modified="2020-12-02" version="1">MAKRNKDVEAEVLNWIFGCLGEPVPKGEFEDILKDGVVLCNLMNKLTPGCIKKIQSKGTNFQLMENIQRFQAAAKKYGLPEEEIFQTADLFERRNIAQVAISLFSLGRITQKHPEWNGPTLGPKMAEENKRTFTEEQLRAHEGQLNLQMGFNKGASQSGHGGFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F327</accession>
    <name>A0A6P7F327_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC114325820</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028129751.1">
        <property type="nucleotide sequence ID" value="XM_028273950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F327"/>
    <dbReference type="FunCoup" id="A0A6P7F327">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273950.2">
        <property type="protein sequence ID" value="XP_028129751.1"/>
        <property type="gene ID" value="LOC114325820"/>
    </dbReference>
    <dbReference type="GeneID" id="114325820"/>
    <dbReference type="KEGG" id="dvv:114325820"/>
    <dbReference type="CTD" id="38070"/>
    <dbReference type="InParanoid" id="A0A6P7F327"/>
    <dbReference type="OrthoDB" id="10030361at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14211">
        <property type="entry name" value="STKc_HIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000022">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="22" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="202"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="778"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="960"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1062"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="990"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_028129751.1"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141779" checksum="BBCF1BAF9BF6000D" modified="2020-12-02" version="1">MHDMFIQSHQLVTNSNSNSSISNNGAVQPKKRKAEHYSNGTGIVSGNTGSEFSFVDQVFSVNGGTQNFGSSSNTTNLSSLTGNNVNNQNTNHNHNGSPSRVNQQPFVRASTIKLLDTYQRCGQKRKTWSPEGNGNSCGEAVIPNTECPISTTTTAHSKVTAAPGGTNPQPQGKQKRSAATSGADGDYQLVQHEVLYSMTNQYEVLEFLGRGTFGQVVKCWKKGTNEIVAIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEYDQIRYISQTQGLPTEHMLNNASKTTKFFYRDMDSTYPFWRLKTPEEHEAETGIKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKVDRKEFIDLLKRMLTMDQERRTTPGEALNHAFVRLAHLVDYAHCNNVKASVQMMEVCRRNDFNNTTSASHHQPTQQAPSLVANFVPSSNGNVTFTINNQLTNQVQRLVRDRSGYDNLYQIYNGRTVGRQYATSSRADPFQHQLVSSILCPAGYQGMGGSPAKHVTVVQQQQLQIPPPILSQPGQQQYVPVSVVEPSGRQMLLTNAVQTSWPTNRQQMAIVPSWQQIPPQHAAIQQPLLSEAEWGRPLLVDSSAILQEQRPVFPVDVAAEVYNPTIVDHTGASWGSSKRSSKNHHGQQSGSHHSHHHLMVPSHHRSQHDKKEQTQLSPVKKRVKEGTPPTEQISYASSSNRRNHSPSNQWHHSSSHQLVSSHDHHTQTVHHHHHHHHHNSSSSNTIAAAPPKQHTITINDTPSPAVSVITISDSEDEVAPGKKTIHTTTQTQPLAPPPPVTAAQRKNVISCVSVQDSDNEERHSVKASTQTHNYNPVIKNEPCQSQHSSQSSQNSSSSSSINYASQKKRILAKAQSECMLNVPTKQEPTDYNYLQHCGSACKEPTQTYQYVSTSQHDQPTYSTSDKRVSWAPPVAHNTSSHSRRHSAVPVVNLQEYAVTAQPHNEYIQPPAAHSTRDSLTVAREQHLLAPGKSWGPPQAIHPSYRHSQAHLSPQPLAAAPRLSPQHPLAAAAGQPLYHQTELYRRPVYVTTTQPAYLPATHQVAPAGRALPPPPAHHASARPVLASHASHPLPAHLQFPSHAQVTAASYGFAPLSPAKSHQYQPASLWFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4K5</accession>
    <name>A0A6P7F4K5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-like protein 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326449</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130624.1">
        <property type="nucleotide sequence ID" value="XM_028274823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4K5"/>
    <dbReference type="FunCoup" id="A0A6P7F4K5">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274823.2">
        <property type="protein sequence ID" value="XP_028130624.1"/>
        <property type="gene ID" value="LOC114326449"/>
    </dbReference>
    <dbReference type="GeneID" id="114326449"/>
    <dbReference type="KEGG" id="dvv:114326449"/>
    <dbReference type="InParanoid" id="A0A6P7F4K5"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028130624.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14963" checksum="9B118AAD8442DD2F" modified="2020-12-02" version="1">MKITIKCLNGGSTLVDVSETSTVAELKKTVEKDLKIPVFQQTIILHGKCLQDDKCLSEYPKIKEGTKLYVAIKKPESFSTTLHTFLKKYYSDEQCKVIVDEFMRNFHSKVESLSLDDLERIAKSELDNLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6H0</accession>
    <name>A0A6P7F6H0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pro-resilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325239</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129040.1">
        <property type="nucleotide sequence ID" value="XM_028273239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6H0"/>
    <dbReference type="FunCoup" id="A0A6P7F6H0">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273239.2">
        <property type="protein sequence ID" value="XP_028129040.1"/>
        <property type="gene ID" value="LOC114325239"/>
    </dbReference>
    <dbReference type="GeneID" id="114325239"/>
    <dbReference type="KEGG" id="dvv:114325239"/>
    <dbReference type="InParanoid" id="A0A6P7F6H0"/>
    <dbReference type="OrthoDB" id="6627027at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129040.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="18478" checksum="9498C7EFDFA0C395" modified="2020-12-02" version="1">MRRSVQSPLDPVNISIMNSYSVVFAFALAAVVVAEPPSGYNYNRPSGGGGISFGGSSLSLGGGLSGGGGYTAVSSGGQTSEGASVDPQLLEQVRQILLKEEQSSSSGGGHGGGGGYPGPSSQYGAPSPQYGVPSYQYRVVGIDLEGIKQAIQVAQYNQISQGPSFGGYPSGPSSIPSGSYGAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8P0</accession>
    <name>A0A6P7F8P0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325884</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129820.1">
        <property type="nucleotide sequence ID" value="XM_028274019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8P0"/>
    <dbReference type="FunCoup" id="A0A6P7F8P0">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274019.2">
        <property type="protein sequence ID" value="XP_028129820.1"/>
        <property type="gene ID" value="LOC114325884"/>
    </dbReference>
    <dbReference type="GeneID" id="114325884"/>
    <dbReference type="KEGG" id="dvv:114325884"/>
    <dbReference type="CTD" id="38515"/>
    <dbReference type="InParanoid" id="A0A6P7F8P0"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF600">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="32"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="535"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028129820.1"/>
        </source>
    </evidence>
    <sequence length="788" mass="89557" checksum="AC97F3E3B388BCE2" modified="2020-12-02" version="1">MFSATKYTPTPRKLRREKTTVSTSSSDSEKDPVHVYCRLRPLRDSDTNTCMNLLSPQEICVSSESKGVRRDISYKFRHIFTAYSSQKEVFDHVAYPLLDDLLKGKNGILFTYGVTGSGKTYTLTGDHNNPGIMPRCINTIFNSVGEFQTPKFIIKSDRMNGFEIQTEEDATQDRLSENRFNSKTPKSARKVNGDKVFTNDGNRIPVLNEMNAYAVFISYVEIYNNNVCDLLDDSTSGKTLQNKILREDQNRNMYVNGVVEVEVKTAQEAFDLFAIGQKRKKMAYTNLNSESSRSHSVFNIRVAQLEKITTNGEGKVVIPERNFLTVSQLSLVDLAGSERSNRTQNTGARLKEASCINNSLMNLRTCLEILRENQRHKGNKVVPYRDSRLTYLFKNYFEGDGSVQMIVCVNPSLSDMEENVHVMKFAEMTQDVKILKSEPRATPISTKKVISKRVATPARIKKVGLFSVVPEIPIFKFDFNEVEECGSIIDNIVTVLKHSKSKHKDLDIEIKKTDKELRKRLVDFDAKKMGNKVEIKNLTHLLQRQQNRNNNLEGKVSRLETEVCTLVTRNKELQDIVKSLHNKINEKDLKLNQNILERERTKQKIALASEQMSQELDAKLKKQREHLNAAMIAKEIQLKKVREALETEIVIDTNDVAIENIPPSSVLTPKTNSEYTHRSMTPYTPKSRRRSKSAGEELWLEHNSIQPVPLGTVLQPSMKKRKSVSKLTKASDILNPKQSKYCLLAQEQDTDGEVETKLYKADILPTTGGGAQVIFNDVERLRQQSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9T8</accession>
    <name>A0A6P7F9T8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327800</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132311.1">
        <property type="nucleotide sequence ID" value="XM_028276510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9T8"/>
    <dbReference type="FunCoup" id="A0A6P7F9T8">
        <property type="interactions" value="1828"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276510.2">
        <property type="protein sequence ID" value="XP_028132311.1"/>
        <property type="gene ID" value="LOC114327800"/>
    </dbReference>
    <dbReference type="GeneID" id="114327800"/>
    <dbReference type="KEGG" id="dvv:114327800"/>
    <dbReference type="CTD" id="36508"/>
    <dbReference type="InParanoid" id="A0A6P7F9T8"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028132311.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24374" checksum="25544B35AB6368C4" modified="2020-12-02" version="1">MALISIRNFLKCGQTISDSIVFNSRNVTLSSHRKSTTSEAKNEAQTSSETETKSPGSADIENLNKQLTELTSQKDELLDKYKRALAEGENLRTRLTKQIADAKIYGIQSFCKDLLDVADVLNKATETVPKEEVTSNNPHLKSLYEGLKMTEAQLMSVFKRHGLEKVNPIDEKFNPNFHEALFQQEVPGKDPNTVVIVSKIGYKLHDRVLRPALVGVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBR2</accession>
    <name>A0A6P7FBR2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">T-box transcription factor TBX10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114327750</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132257.1">
        <property type="nucleotide sequence ID" value="XM_028276456.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503844.1">
        <property type="nucleotide sequence ID" value="XM_050647887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647887.1">
        <property type="protein sequence ID" value="XP_050503844.1"/>
        <property type="gene ID" value="LOC114327750"/>
    </dbReference>
    <dbReference type="GeneID" id="114327750"/>
    <dbReference type="KEGG" id="dvv:114327750"/>
    <dbReference type="InParanoid" id="A0A6P7FBR2"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20187">
        <property type="entry name" value="T-box_TBX1_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000006">
        <property type="entry name" value="T-box transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF195">
        <property type="entry name" value="OPTOMOTOR-BLIND-RELATED-GENE-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="8">
        <location>
            <begin position="96"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028132257.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="49218" checksum="FD3A70EE291700C4" modified="2020-12-02" version="1">MDSSTVPYQSHFGYSSSDMSWSYASNITPMKQIEACLQSAGKDRKAYSPLDQADALSLDENDTNRTENNNRTTAHNKNHSNSNTTSPALANAGAILEMKHLWDEFHSLGTEMIVTKAGRRMFPTFQVKLCGLDLHSEYMLMMDFVPVDDKRYRYAFHSSSWVIAGKADPVSPPRIHVHPDSPATGAQWMKQTVSFDKLKLTNNQLDDNGHIILNSMHRYQPRFHIVYLPPKNLSSADENSNENFKTFVFSETSFTAVTAYQNHRITQLKIASNPFAKGFRDCDPDDSSEVVSQPAPSPRNRPTSRSTPNNLNKDDDTQDQNLHSTENTRQTHPSMIFQNRYQNTTQSTAPPLLQSNILSAGLSTIGQPYSADICNYGPMYHSHNLLHNYNPVYSNEKAMRAPNFGRTVYGNYSGFYGNNGNFRSAGLHQNGYDFSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCS2</accession>
    <name>A0A6P7FCS2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 161B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114328985</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM161 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133789.1">
        <property type="nucleotide sequence ID" value="XM_028277988.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515731.1">
        <property type="nucleotide sequence ID" value="XM_050659774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCS2"/>
    <dbReference type="FunCoup" id="A0A6P7FCS2">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659774.1">
        <property type="protein sequence ID" value="XP_050515731.1"/>
        <property type="gene ID" value="LOC114328985"/>
    </dbReference>
    <dbReference type="GeneID" id="114328985"/>
    <dbReference type="KEGG" id="dvv:114328985"/>
    <dbReference type="CTD" id="39250"/>
    <dbReference type="InParanoid" id="A0A6P7FCS2"/>
    <dbReference type="OrthoDB" id="784140at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019395">
        <property type="entry name" value="Transmembrane_161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624:SF6">
        <property type="entry name" value="EMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624">
        <property type="entry name" value="RE42071P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10268">
        <property type="entry name" value="Tmemb_161AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028294503" evidence="8">
        <location>
            <begin position="21"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028133789.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57089" checksum="6213D0FD8716147F" modified="2020-12-02" version="1">MALLGAQLVITLVMISVIQKLGPHYSLARWLLCSTGLVRYLYPTDSELRELANIPKEKSKNRKNSKAQTNGKTTVDTFHIPRSLDIKLDSIKITRQDVIHIRYYTEYQWLVDFSVYAAVIYGATELYQVWFPLKNEINLSMVWCFLVILFAIKLLLGLTVQYFKGEESIGERSTCIVMGFIYLLISMMILIVDEKTLEIGLEDAYDSFNKSASVFLEKQGLSSTGPASKIVLKFFMAVWCGVLGALFTFPGIRLAKMHWVLLKYFQDNKLKQLLLNFTFALPFILIIFWIKPVSRDYLTVRIFNGRTEPLMTEDAFDSLRLLAIVATMCLKLVLMPWYLQAYLDMAFHRLENQKKEAGRITNTELQKQIAAVFYYLCVVTLQYVAPIVLCSFFTLMYKTLGEYQWTGELLKYQPSDNDTMTATEKSLPSMEIFGSSEDSKSISDTAAEFHLTLESLKSVFPKTVFRGLFGFATWWCCFLYFATTSFGLIYQSYFSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FE48</accession>
    <name>A0A6P7FE48_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidoglycan-recognition protein LB-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Peptidoglycan-recognition protein LB-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC114327272</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the prophenoloxidase (proPO) cascade immune response. Binds to 1,3-beta-D-glucan and PGN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131627.1">
        <property type="nucleotide sequence ID" value="XM_028275826.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131635.1">
        <property type="nucleotide sequence ID" value="XM_028275834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FE48"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275826.2">
        <property type="protein sequence ID" value="XP_028131627.1"/>
        <property type="gene ID" value="LOC114327272"/>
    </dbReference>
    <dbReference type="GeneID" id="114327272"/>
    <dbReference type="KEGG" id="dvv:114327272"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF77">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650924" evidence="6">
        <location>
            <begin position="28"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="8">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028131627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028131635.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27444" checksum="000CFFA8434B18F8" modified="2020-12-02" version="1">MSRLNIFSFLKMLQALCCVLGVTSASSDPVIVSREEWGARAPKNIENMANPVPYVVIHHSYLPPACYNLTDCFKAMRWMQDLHQDTNGWADIGYNFGVGGDGRAYEGRGWSRVGAHAPYYNSKSIGICIIGDWTVELPPENQLATVHELIQKGVREGYIQKDYKLVGHRQVRQGTECPGDRLFKEIHKWQNFCEQPDEIAVRTNNTWFLKKTVHDNSRDKEDKDEDNNDNGINRLEKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFZ0</accession>
    <name>A0A6P7FFZ0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phenoloxidase-activating factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114327663</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132138.1">
        <property type="nucleotide sequence ID" value="XM_028276337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFZ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276337.2">
        <property type="protein sequence ID" value="XP_028132138.1"/>
        <property type="gene ID" value="LOC114327663"/>
    </dbReference>
    <dbReference type="GeneID" id="114327663"/>
    <dbReference type="KEGG" id="dvv:114327663"/>
    <dbReference type="InParanoid" id="A0A6P7FFZ0"/>
    <dbReference type="OrthoDB" id="9028152at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028310553" evidence="5">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="45"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028132138.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32396" checksum="F0E60883BE563498" modified="2020-12-02" version="1">MKRRHTLRCCFLLILFYHCTSVVIAESNLIISDTQCGFSRVDERPSGGRITLDGEFPWTARLHYNRSKTSCEGTLISKRIVLTAGLCLTRKTQKRLGRLMTVNLGDHNCRPHKQCKDEHINIPVEKLFIHRELKTEGPMPQNNIGIVKLAQDVEFNEHIKPICLPKFDDEVVADNWVTETGWDVHKNKKLKVDLPVISYKECSKLYFNSRIPIYNNQLCAGGETDDSCVALSGGSLMSKRKDAPNQWYLEGIVSAGPRQCAVGGLPNVYTKVQPYLNWIQEYMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH81</accession>
    <name>A0A6P7FH81_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114328028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114328028</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132570.1">
        <property type="nucleotide sequence ID" value="XM_028276769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH81"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657845.1">
        <property type="protein sequence ID" value="XP_050513802.1"/>
        <property type="gene ID" value="LOC126889504"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FH81"/>
    <dbReference type="OrthoDB" id="6159213at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="32"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132570.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28765" checksum="64FC1FBBE283DC9B" modified="2020-12-02" version="1">MDNLEEMEEIQENMEELYEVENVEQECTVEELLIACVMDRPPLWDSRLPIKVRSKTTRDKMWQEIYTVFGENPQYSIEFLSKKWRNLRDTYVRIRNDYTPSGSGAVKKKKWEYFDSLHFLKDTVNYKNTVSNVKPSCGGSSSLLNTKPSCSGSGSSSPKVNIIGSDSATSPHVPLLGGEESEPLVATPKRDKVEGAILDTIKRINEEPPPQPVTVNPICQRISELLQHMPQGPRTLLEIKLLEVAYDGAKSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI30</accession>
    <name>A0A6P7FI30_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Translocating chain-associated membrane protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114328160</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132743.1">
        <property type="nucleotide sequence ID" value="XM_028276942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI30"/>
    <dbReference type="FunCoup" id="A0A6P7FI30">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276942.2">
        <property type="protein sequence ID" value="XP_028132743.1"/>
        <property type="gene ID" value="LOC114328160"/>
    </dbReference>
    <dbReference type="GeneID" id="114328160"/>
    <dbReference type="KEGG" id="dvv:114328160"/>
    <dbReference type="CTD" id="31042"/>
    <dbReference type="InParanoid" id="A0A6P7FI30"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016447">
        <property type="entry name" value="Translocation_assoc_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371:SF11">
        <property type="entry name" value="TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12371">
        <property type="entry name" value="TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="10">
        <location>
            <begin position="112"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028132743.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41704" checksum="A3D25DE9FD6EF162" modified="2020-12-02" version="1">MVKPVRKSANKNPPILSHEFVIQNHADIVSCIAMVFVVGLMVQATSPIASIFITLQHNVTEAGEVPLYSPGVKDWACIFFYTLICVVIHAIIQEYILDKVSKKLHLSKSKLAVFTTSGQLTIFYLISTLWGLDIIIKENFVFDIARLWVDYPAPMTFLMKLYIIVQLAYNVHELPELYFQRAKKEEYIGKATQSLAAVSLIFIPYFLNFNRLLVSLLVLHHISELVYHFFQLIQTVDKDEKFSKVTTLVSNSFKLVARLGSIILSILTLWYGLALGEQRELDLTTGYYNTPVVRIAVLAGILGLQMYLTFNVISQEIARSRESKGASVAPKAKPQKKEKSKKTKKSEESDLPEVDQNTNKTLKKQKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJI5</accession>
    <name>A0A6P7FJI5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Growth arrest-specific protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114328641</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133355.1">
        <property type="nucleotide sequence ID" value="XM_028277554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJI5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277554.2">
        <property type="protein sequence ID" value="XP_028133355.1"/>
        <property type="gene ID" value="LOC114328641"/>
    </dbReference>
    <dbReference type="GeneID" id="114328641"/>
    <dbReference type="KEGG" id="dvv:114328641"/>
    <dbReference type="OrthoDB" id="5950623at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039596">
        <property type="entry name" value="GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16840">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16840:SF3">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027894977" evidence="6">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="7">
        <location>
            <begin position="116"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028133355.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28549" checksum="1AC54B1BCE3683F4" modified="2020-12-02" version="1">MKSGMWLIMVSVAWLAGVTSGIPCEEARLKCAYRVGCGMALQHYLVGCSAVLQGDTFPEYCPEVCQYTLTALTSTEEGMALMNCECSDDYCRDQKVRTDICKPKVMHSMSSDVVPCRVAQWICMADALCAKALEYYNEFCKAMFHGKKCTLRCNNSINILRRQEKATKLKTCKCDGYEDYDCHGIQRNMDKLCFHKHSRHHNRTHTEWPHNTTHREFKEDEEIPTVILASSSLKLTISWAVMFSIVLALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FN23</accession>
    <name>A0A6P7FN23_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 235-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114329494</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134424.2">
        <property type="nucleotide sequence ID" value="XM_028278623.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028134425.1">
        <property type="nucleotide sequence ID" value="XM_028278624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FN23"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278623.2">
        <property type="protein sequence ID" value="XP_028134424.2"/>
        <property type="gene ID" value="LOC114329494"/>
    </dbReference>
    <dbReference type="GeneID" id="114329494"/>
    <dbReference type="KEGG" id="dvv:114329494"/>
    <dbReference type="OrthoDB" id="8300205at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002394">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134424.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028134425.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="60492" checksum="FAA611270A70B899" modified="2020-12-02" version="1">MFTMEFKVEVKEEFIEYNKQSIDTPVPTLIGMEHLKNEPEDNSGMEVKPEIKKEFAENNQGYIQNQLYTSIELGELKNEIDEDNSGFSQNIMEIMKTKLASTTEQQISANTEETTSNSSYCKCNICFRQFNEAGSLEQHLKTHTEEKPYKCEICFMQFSRKGNLKRHLIVHTGEKPHKCEICFKLFSQAGSLNKHLRVHTGEKSYKCEICSKQHSRMDNLKSHLRTHSGEKSYKCEICFKLFTHKHSLDKHKRLHTGEKPYGCEICFQQFSQKSNLNTHLILHTGEKQYKCEICFKQFSRSDHLKNHLRTHTGEKSYKCEICFKLFTTKQSLDEHKRLHTGEKPYKCEICFQRFSHAVSLKTHLILHTGENPYKCEICFKQFGLADDLKKHLRVHTGEKPYKCEICFRQFSQKSNLNTHLILHTGEKQYKCEICFKQFSLKCNLKGHLRVHTGEKPYKCEICFKQFSEAGSLKKHLTVHTGETPYKCESCSEQFFQKVHLKKHLKVHTEEKLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQE3</accession>
    <name>A0A6P7FQE3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114330104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135223.1">
        <property type="nucleotide sequence ID" value="XM_028279422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQE3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279422.2">
        <property type="protein sequence ID" value="XP_028135223.1"/>
        <property type="gene ID" value="LOC114330104"/>
    </dbReference>
    <dbReference type="GeneID" id="114330104"/>
    <dbReference type="KEGG" id="dvv:114330104"/>
    <dbReference type="InParanoid" id="A0A6P7FQE3"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028139628" evidence="1">
        <location>
            <begin position="18"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135223.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="14128" checksum="2D64674C2FAD08C3" modified="2020-12-02" version="1">MKVLTLTFVLFVPYVISQNIAQFTPLIAAHQACASRTGIQPDLVSGMLQGRFPNNPALADHLFCIHKRLGIQDSDGSINTNRIGQLAGIIAPNASPERIQEVINVCAVQKGSPGATALDMDRCLYNQAGGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSZ5</accession>
    <name>A0A6P7FSZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114330852 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136078.1">
        <property type="nucleotide sequence ID" value="XM_028280277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280277.2">
        <property type="protein sequence ID" value="XP_028136078.1"/>
        <property type="gene ID" value="LOC114330852"/>
    </dbReference>
    <dbReference type="GeneID" id="114330852"/>
    <dbReference type="KEGG" id="dvv:114330852"/>
    <dbReference type="InParanoid" id="A0A6P7FSZ5"/>
    <dbReference type="OrthoDB" id="7971361at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028042923" evidence="1">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028136078.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14195" checksum="C866C4B2E62C9A42" modified="2020-12-02" version="1">MYTKIVVLFALVAVFALTDGRVTHCERHNGDREFRCAKDDYRADTIAVHNRAGNRISFKVGKWLSRCGRPGQNYSDQEYHLGSGENINIDFSEVGSGSCNELFIYQCRIDNRDANCLDTVTATPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FV96</accession>
    <name>A0A6P7FV96_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114334537</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140399.1">
        <property type="nucleotide sequence ID" value="XM_028284598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FV96"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284598.2">
        <property type="protein sequence ID" value="XP_028140399.1"/>
        <property type="gene ID" value="LOC114334537"/>
    </dbReference>
    <dbReference type="GeneID" id="114334537"/>
    <dbReference type="KEGG" id="dvv:114334537"/>
    <dbReference type="InParanoid" id="A0A6P7FV96"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028401273" evidence="3">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028140399.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="43676" checksum="6F401093E43D9C8B" modified="2020-12-02" version="1">MCFNKFVIAVLFMFINKSFSDCVKNRNKLVCEDIRQISQRFFNETTNTLQGITSIEIRNDNQVLGVGVDSFSDGKNLEVLMLFKSNIHKLYSETFKDLPELRRLYLYYNQITDLYPKTFSNLPKLSNLLLNNNNLKFIRPGVFKNLPALNSLDLDNNLLSNIEDGVLANFPNLSRLKLNGNNIETIFVHKIISFPEKLEILWLHNNSLTVVSNFMLQNLVSLKVLNLGFNKISTIEAGSFSQTPNLITLVLTNNNLKELDGSAFPIRGLDLLDNLYIDHNYLMFLRSSFFIRLSGLKKITLMGNPWFCNCLYDIYRVISENNIEEKCQGDYVNAKRPICVSDGVDVKVCQYRYNVTMRDKYLEVDRSIAFDMNPLNCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXP3</accession>
    <name>A0A6P7FXP3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114335235</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141236.1">
        <property type="nucleotide sequence ID" value="XM_028285435.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511264.1">
        <property type="nucleotide sequence ID" value="XM_050655307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXP3"/>
    <dbReference type="FunCoup" id="A0A6P7FXP3">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655307.1">
        <property type="protein sequence ID" value="XP_050511264.1"/>
        <property type="gene ID" value="LOC114335235"/>
    </dbReference>
    <dbReference type="GeneID" id="114335235"/>
    <dbReference type="KEGG" id="dvv:114335235"/>
    <dbReference type="CTD" id="35287"/>
    <dbReference type="InParanoid" id="A0A6P7FXP3"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028141236.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="76735" checksum="61ED4484BACFCC3F" modified="2020-12-02" version="1">MAEASTSSLVTSTPMVSDPRRRSILVNTNAPSPLRRSLNTSSLNSSFVEVPNDDDQRAARRSIAKIQRRLTNVSPVKSVNLSESFIKDQYVVYTHLFAENKITSKNAWKLQIIDMLKPLCQKSGKDVLQVATTSIDISAKVYGIRVDDVHSEGLKLANNMARVANTDEPDNDEGEQSGGEQDNAAAASKKKKRKRPNQTGVKSTINKNPKGNLGKLPKLEPTDFTTRVKPDAGTIDNLFTNMLKETSNCFIVLDKNKKYFEESDSIVKKEEKISMKNIKIPKTVGSINPSFNDFIVDVWDPDQEEKRLNENSMLSQIQPVVFDDRGFPIPELDGSIHDIFETNDMDVDVDDDDVIEVRQAESLLPQIRDSVHVVDYRPMEMSIQTSEYSFNPVVRTSNGKYIDQIWAGPSHWKLKFIRRSTPRFSGRANTTEKQPTKRGRKKPIVEKINYEAEPPEINFNNELVIKKKPPAVDMHKITLPLMDQSCARIMETMKELMLKPGVCPVEKSAVKKDENRDEIEVSPYKYENPNDSLYCSQNQDDNDNDADMDNDNIAGDDEHLVQFGGNLTDNLVENPEMVPSTYIQYAKQAKQINMKKLKSAIWYKLTNVTIETQDTNVKIIPQTYSELYKALPDIMPSKEKEKLSCPLAFFALLHLTNEKNLSLSRMPGKNDCYIEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZE6</accession>
    <name>A0A6P7FZE6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114334307</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140147.1">
        <property type="nucleotide sequence ID" value="XM_028284346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZE6"/>
    <dbReference type="FunCoup" id="A0A6P7FZE6">
        <property type="interactions" value="1194"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284346.2">
        <property type="protein sequence ID" value="XP_028140147.1"/>
        <property type="gene ID" value="LOC114334307"/>
    </dbReference>
    <dbReference type="GeneID" id="114334307"/>
    <dbReference type="KEGG" id="dvv:114334307"/>
    <dbReference type="InParanoid" id="A0A6P7FZE6"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028140147.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29985" checksum="9612FDEF124C3650" modified="2020-12-02" version="1">MYLRPLLSQLARNKPLQTSLVQHASRTLSTEVDSKTETRPTVRKPNLVARSSLTDFGKYVAECLPKYVERVQITAGDELEVLIVPEGILPVLQFLKDHHNSQFSNLADIAGMDVPSRPYRFEIIYNILSLRFNSRIRVKTYTDELTPVESCNDIYKAANWYEREIWDMYGVFFSNHPDLRRILTDYGFEGHPFRKDFPLSGYVEVRYDDEKKRVVVEPLELAQEFRKFELSAPWEQFPNFRNANPASEEVDISKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5L4</accession>
    <name>A0A6P7G5L4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Serine/arginine repetitive matrix protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8 9 10" type="primary">LOC114337958</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144335.1">
        <property type="nucleotide sequence ID" value="XM_028288534.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144336.1">
        <property type="nucleotide sequence ID" value="XM_028288535.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144337.1">
        <property type="nucleotide sequence ID" value="XM_028288536.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144338.1">
        <property type="nucleotide sequence ID" value="XM_028288537.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144339.1">
        <property type="nucleotide sequence ID" value="XM_028288538.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144340.1">
        <property type="nucleotide sequence ID" value="XM_028288539.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144341.1">
        <property type="nucleotide sequence ID" value="XM_028288540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5L4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655360.1">
        <property type="protein sequence ID" value="XP_050511317.1"/>
        <property type="gene ID" value="LOC126887699"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655361.1">
        <property type="protein sequence ID" value="XP_050511318.1"/>
        <property type="gene ID" value="LOC126887699"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655362.1">
        <property type="protein sequence ID" value="XP_050511319.1"/>
        <property type="gene ID" value="LOC126887699"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655363.1">
        <property type="protein sequence ID" value="XP_050511320.1"/>
        <property type="gene ID" value="LOC126887699"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655364.1">
        <property type="protein sequence ID" value="XP_050511321.1"/>
        <property type="gene ID" value="LOC126887699"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655365.1">
        <property type="protein sequence ID" value="XP_050511322.1"/>
        <property type="gene ID" value="LOC126887699"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8197488at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043407">
        <property type="entry name" value="Nkap_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940:SF1">
        <property type="entry name" value="NKAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940">
        <property type="entry name" value="NKAP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15692">
        <property type="entry name" value="NKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028144335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028144336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028144337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028144339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028144340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028144341.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="58596" checksum="85B1A3AB9D26CD5E" modified="2020-12-02" version="1">MSSRRRSRSRDRKNVPAKLRMDTKPQAIRITDPSLPAGRRREIDNVMKKARAQKSPNSGVFWDKKLLEVEAKDPNRWRHSGYQSLYIDGSSSPSSNGRRSRSRSFGHGSSPATGRRTSPTSMRRTSPAMYGGRSARSPRSPRSPPPRSTRSRSRSSSPHARRRSPPPSYRRHVPGGGRPRSPPSPRDPPSSRHLKRRSVSNSSISSCSDDSCSVCSPKAHRNARTRSRSFSPRPRKQPPKVVSPPPKSRVRQRPPSPSPVPKRVPRPTTPPPVQRKIPKPSTSDRPTDPRRQPPPPRPRGSTGEIINVRGVKPPAKPGTFKKIGEKPMVKPMVLKRIKKERTGNRPGSPGGESSGSADSAPSVLPSPIVATTNLTLSERFGKIAQWSADRERREMENMRITKTGGSMKVLVEEDFLYGSPPRRYSISPVPTGHFPDKLMSSGQSRLAAWDDVRVRYQYYKDLGYLRDLTLDDYVKWEEWWYKYQDWLANERHYEHWLATQGGSGRRRGKKRLPATQRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9I3</accession>
    <name>A0A6P7G9I3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">acylphosphatase</fullName>
            <ecNumber evidence="2 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114335170</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_028141150.1">
        <property type="nucleotide sequence ID" value="XM_028285349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9I3"/>
    <dbReference type="FunCoup" id="A0A6P7G9I3">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285349.2">
        <property type="protein sequence ID" value="XP_028141150.1"/>
        <property type="gene ID" value="LOC114335170"/>
    </dbReference>
    <dbReference type="GeneID" id="114335170"/>
    <dbReference type="KEGG" id="dvv:114335170"/>
    <dbReference type="InParanoid" id="A0A6P7G9I3"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028141150.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14972" checksum="DE34B0050FB27E82" modified="2020-12-02" version="1">MIKLFPFNAKLLICAIIIIFTSCTRYTYTANMSSETLLSVDFEVFGRVQGVFFRKYTEKEAKRLNLKGWCMNTKQDTVKGIIEGPTKNVEEMKLWLQETGSPSSRIDKAVFSNQKTINQYTYDSFKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GB54</accession>
    <name>A0A6P7GB54_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Inhibitor of apoptosis isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114335598</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141650.1">
        <property type="nucleotide sequence ID" value="XM_028285849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GB54"/>
    <dbReference type="FunCoup" id="A0A6P7GB54">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285849.2">
        <property type="protein sequence ID" value="XP_028141650.1"/>
        <property type="gene ID" value="LOC114335598"/>
    </dbReference>
    <dbReference type="GeneID" id="114335598"/>
    <dbReference type="KEGG" id="dvv:114335598"/>
    <dbReference type="CTD" id="39753"/>
    <dbReference type="InParanoid" id="A0A6P7GB54"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase XIAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF174">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01282">
        <property type="entry name" value="BIR_REPEAT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028141650.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40899" checksum="7C0AA6BE59CA9FEA" modified="2020-12-02" version="1">MTHIVKWLWTKLFHGTKMAVVQSNYIQNIPSFGCVDQPDNGSKTTRESLVEVSSSRPRQEDYSVYENRLASFTNWPNTQVSRESLARAGFIYTGQDDIVICPICKIEGYRWVSGDNPMDDHRVWNPNCPFLNRRDNIEHDHSVGSRDTCGLFGIELLPNSVPEDNTSNLQKLGIQPGTGPQNQDKITLESRLATFQGWPKSIKQRPSELAEAGFYYTGAGDQTVCFYCGGGLKDWDEGDDPWEQHALWFSKCVFLNLKKGKEFIDQVKRKADPQFSIPGPSGTQAKEEPTATESSSDKQSETVKTKSDRESFATDTTLCKICFKNELGVVFLPCGHIVACVDCAAALKTCAVCRKPLEATVRAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBJ5</accession>
    <name>A0A6P7GBJ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Uncharacterized protein LOC114340192 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC114340192</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11 12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146713.1">
        <property type="nucleotide sequence ID" value="XM_028290912.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146720.1">
        <property type="nucleotide sequence ID" value="XM_028290919.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146726.1">
        <property type="nucleotide sequence ID" value="XM_028290925.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503797.1">
        <property type="nucleotide sequence ID" value="XM_050647840.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503798.1">
        <property type="nucleotide sequence ID" value="XM_050647841.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503799.1">
        <property type="nucleotide sequence ID" value="XM_050647842.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503800.1">
        <property type="nucleotide sequence ID" value="XM_050647843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBJ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647840.1">
        <property type="protein sequence ID" value="XP_050503797.1"/>
        <property type="gene ID" value="LOC114340192"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647841.1">
        <property type="protein sequence ID" value="XP_050503798.1"/>
        <property type="gene ID" value="LOC114340192"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647842.1">
        <property type="protein sequence ID" value="XP_050503799.1"/>
        <property type="gene ID" value="LOC114340192"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647843.1">
        <property type="protein sequence ID" value="XP_050503800.1"/>
        <property type="gene ID" value="LOC114340192"/>
    </dbReference>
    <dbReference type="GeneID" id="114340192"/>
    <dbReference type="KEGG" id="dvv:114340192"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028146713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028146720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028146726.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40115" checksum="021AD29361865E84" modified="2020-12-02" version="1">MAPPGIGNSVEIRPEATASSAERSSSNGVATFQKDIVVLDGGFATQLGCHVQQPIDGDVLWSSRFLATNPEAVIDTHLDFLRAGADVIITNTYQADVNLFAKHLNMTKEEGYNLIKDSVKMAKTAVERYLKEYPEARKPLIAGSVGPYGASLHDGSEYTGAYAKTTSAETMREWHGPRIKALVEGGVDLLAIETIPNAVEAEMLVQLIKEEYPNVKAWLAFSVAQDGKSIAYGEDFKTIARKCYDSNPEQLVAIGINCTAPRLIEPLLTGINDDRKDNPRPLIVYPNSGESYNVELGEWSQSSLTDGPRDDSRWHNRENCEPVDTNIHKWLDLGVTWVGGCCRTYAVDVTRIRDQVQLWKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GC09</accession>
    <name>A0A6P7GC09_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endoplasmic reticulum transmembrane helix translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endoplasmic reticulum P5A-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC114336256</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142388.1">
        <property type="nucleotide sequence ID" value="XM_028286587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GC09"/>
    <dbReference type="FunCoup" id="A0A6P7GC09">
        <property type="interactions" value="2304"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660004.1">
        <property type="protein sequence ID" value="XP_050515961.1"/>
        <property type="gene ID" value="LOC126890813"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GC09"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000014">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="964"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1001"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1130"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="23">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="22">
        <location>
            <begin position="256"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="841"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_028142388.1"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131077" checksum="476CE417A8250640" modified="2020-12-02" version="1">MSVTPKLDDLVQYVSLYTRLPTLLHLYLLPFILIYSAWLYLWLGIYGFYEHYEGGFVGLAVIGCLQVLSCLACYWSVHVNCFFSCRKVKDPHKATLAKVIPTPNNGSSELVWLRHNRLETGPSIWFMFQKTKYIWNSDKKTFRGLEFPIHKSFSEYMGSKGLQEDADLLEAEQLYGKNFLDMGVPEFKTLFTERATAPFFVFQVFCVGLWCLDDFWYYSLFTLVMLVLFECTLVQQQLRNMDEIRKMGNKPYNILAYRSRKWRMLTTTELIPGDIISITRSQKDNLIPCDVLLLRGTCIVDESMLTGESVPQMKEAIENFDQKTVLDPEGEGKLHVLFGGTKVVQHTPPTKATTGLRPQDGGCVAYVLRTGFNTSQGKLLRTILFGVKRVTANNMETFGFIVFLLVFAIAAAWYVWTKGIEDPKRNRYQLFLECTLILTSVIPPELPIELSLAVNTSLLALSKLAVFCTEPFRIPFAGKVDICCFDKTGTLTSDNLVVEGVALAEKDSTPTAVADLPAQTLQVLATCHSLVQLDDGLVGDPLEKATLTAIDWNVTKADAVVPKKGKLPGLKIFHRYHFSSALKRMSVIAGYNAVGSTDTIYIATVKGAPETLKSMFSETPKLYDDVYLELSRRGARVLALGFKEMGRLSSQEIRDLSREDVEKDLKFAGFAIISCPLKTDSKSVIKELQYASHKAVMITGDNPLTACHVAKELKFTTKTTVILTQADDIYIWRSIDESKELPLEYDYKKLIKEYDLCITGDGLNHLRDRYNAFLRLIMPYITVYARFAPKQKEFVVTQLKHLGYVTLMCGDGTNDVGALKHADVGVAILANAPEKLPDPKVQKEKLEKEREKKQKELKEAMSAQRPNHVRNMINQRDKLQSKVDKMMKEIEEDQTPIVKLGDASIASPFTSKLSSIMCICHIIKQGRCTLVTTLQMFKILALNALILAYTQSVLYLDGIKLRDAQATLQGLLVAACFLFISRSKPLKVLSKQRPLPNIFNLYTILTVITQFAVHFCCLIYLVQEAKLRSLPEDDPLKIEALDISDEEKEKLFKPNIVNSTVYIISMALQIATFAINYRGRPYMENLIENKPLLYSVLGTGSVVLLLTLGLVPELSASFEIIDFPPDFRIILLQILFADFFFSFLLDRLCLWLCGEGSMRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD63</accession>
    <name>A0A6P7GD63_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114340799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147374.1">
        <property type="nucleotide sequence ID" value="XM_028291573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GD63"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291573.2">
        <property type="protein sequence ID" value="XP_028147374.1"/>
        <property type="gene ID" value="LOC114340799"/>
    </dbReference>
    <dbReference type="GeneID" id="114340799"/>
    <dbReference type="KEGG" id="dvv:114340799"/>
    <dbReference type="InParanoid" id="A0A6P7GD63"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027670589" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147374.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12336" checksum="30EDAA9F92C1903D" modified="2020-12-02" version="1">MFKLVVLFGLAAVVAARPSGWETPVVSYSLPAVAVPAAVSSTYRRDVINKPVIAYSAHPVVAAPVVHNVVSSPVLPLSAAATHSFRSDLVSSPWVVAHEAPALLAEPVWPAAASIHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDS7</accession>
    <name>A0A6P7GDS7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114341036</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114341036</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028147626.1">
        <property type="nucleotide sequence ID" value="XM_028291825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDS7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291825.1">
        <property type="protein sequence ID" value="XP_028147626.1"/>
        <property type="gene ID" value="LOC114341036"/>
    </dbReference>
    <dbReference type="GeneID" id="114341036"/>
    <dbReference type="KEGG" id="dvv:114341036"/>
    <dbReference type="InParanoid" id="A0A6P7GDS7"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028147626.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25638" checksum="9360A0D7EC11B0BE" modified="2020-12-02" version="1">MPYHASCYVVQCQNTWRNSDVKYFYFPRSQSKVDQRIKWINAIRRINSDKSQWTPKSTDMVCSAHFIGNVKSSDPLNPNYVPTIFPEVYKRKKNFSAQNRYKRLMNRRTRNISNLLDRENVNENDDSNSSDRENDVVEVDEEINVALDIQPVRQTVDVGCQVFMEDSSKHKTSSKIYGGRKSDSQISVESGILVLLEDRDVILADKGFPEVKASIDERGKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHI7</accession>
    <name>A0A6P7GHI7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114342687</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028149291.1">
        <property type="nucleotide sequence ID" value="XM_028293490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHI7"/>
    <dbReference type="FunCoup" id="A0A6P7GHI7">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293490.2">
        <property type="protein sequence ID" value="XP_028149291.1"/>
        <property type="gene ID" value="LOC114342687"/>
    </dbReference>
    <dbReference type="GeneID" id="114342687"/>
    <dbReference type="KEGG" id="dvv:114342687"/>
    <dbReference type="CTD" id="37850"/>
    <dbReference type="InParanoid" id="A0A6P7GHI7"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04176">
        <property type="entry name" value="Rap2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000189">
        <property type="entry name" value="Member of ras oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041840">
        <property type="entry name" value="Rap2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028149291.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20634" checksum="2244E3E2D49AFD75" modified="2020-12-02" version="1">MREFKVVVLGSGGVGKSALTVQFVSGCFMEKYDPTIEDFYRKEIEVDNSPCVLEILDTAGTEQFASMRDLYIKNGQGFVVVYSLTNHQTFQDIRPMKELITRVKGTERVPILLVANKVDLDHQREVDYAEGNVLSQQWGCPFIEASAKNRTNVNEVFAEIVREMNFSPEKEKPSYCWCTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIE3</accession>
    <name>A0A6P7GIE3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Syntaxin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114337347</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143555.1">
        <property type="nucleotide sequence ID" value="XM_028287754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIE3"/>
    <dbReference type="FunCoup" id="A0A6P7GIE3">
        <property type="interactions" value="2173"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287754.2">
        <property type="protein sequence ID" value="XP_028143555.1"/>
        <property type="gene ID" value="LOC114337347"/>
    </dbReference>
    <dbReference type="GeneID" id="114337347"/>
    <dbReference type="KEGG" id="dvv:114337347"/>
    <dbReference type="InParanoid" id="A0A6P7GIE3"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000022">
        <property type="entry name" value="Syntaxin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="277"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028143555.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42003" checksum="1DA4E90455FD83E9" modified="2020-12-02" version="1">MLPRRRRAGSETEPQVIVGNDNYWTNPQPKTNQSHTVYPNNVTSDYYLEEDYIEDYTEPELVMTARDRTSEFVNTIQTLQGRNIARAVAARDPKKSRVIQSHSEFMLIAKNVGRHIASTYAKLEKLTLLAKRKSLFDDKTSEIQELTYIIKGDLSNLNQQIAQLQDVSRKQKQGSSGKHLQSHTSSIVLALQSKLASMSTDFKQVLEVRTENLRHQKNRRDQFSQGGLPPPTVASSSAQGSLLFQEQDQVSINMESAALIPKGQTQIQASLMYDQTDNYLQSRAETMQNIESTIVELGGIFQQLAHMVKEQEEMVERIDSNVEHAELNIEAAHAQIVKYFKNISSNRWLMIKIFGVLIVFFIFFTVFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIS7</accession>
    <name>A0A6P7GIS7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aldose reductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114343211</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149821.1">
        <property type="nucleotide sequence ID" value="XM_028294020.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514137.1">
        <property type="nucleotide sequence ID" value="XM_050658180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIS7"/>
    <dbReference type="FunCoup" id="A0A6P7GIS7">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658180.1">
        <property type="protein sequence ID" value="XP_050514137.1"/>
        <property type="gene ID" value="LOC114343211"/>
    </dbReference>
    <dbReference type="GeneID" id="114343211"/>
    <dbReference type="KEGG" id="dvv:114343211"/>
    <dbReference type="InParanoid" id="A0A6P7GIS7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028149821.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35915" checksum="9B7768E22C9F1728" modified="2020-12-02" version="1">MVQVPTVKFNNGNEIPIFGLGTWKSKPGEVAQAVKDAIDIGYRHIDCAFVYGNEKEVGEALAAKFADGTVKREDIFITSKLWNTYHRPDLVEKCLQQTLSNLGIQYLDLYLIHWPMAYKEDLDIFPRREDGSIIFSDVDYVDTWKEMEKVQQKGLVKSIGVSNFNEKQIERVLKIAKIKPVNNQVECHPYLNQKKLIDFCRSKDITVTAYSPLGSPDRPFAKPGDVELLHDPKLKDLAAKHNKSPAQILLRFQVERGVIVIPKSVNKGRLEQNIDIFDFSLSKEDLATLESFDCDGRLIRLDAALGHPHHPFLPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GK26</accession>
    <name>A0A6P7GK26_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114339131</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in an early step of the mitochondrial complex IV assembly process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145563.1">
        <property type="nucleotide sequence ID" value="XM_028289762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GK26"/>
    <dbReference type="FunCoup" id="A0A6P7GK26">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289762.2">
        <property type="protein sequence ID" value="XP_028145563.1"/>
        <property type="gene ID" value="LOC114339131"/>
    </dbReference>
    <dbReference type="GeneID" id="114339131"/>
    <dbReference type="KEGG" id="dvv:114339131"/>
    <dbReference type="InParanoid" id="A0A6P7GK26"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028145563.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9638" checksum="478272D83F1E47A9" modified="2020-12-02" version="1">MMRYEEENEKLADTSPCAGVRADLKMCLLESDCCKIQKRTPRECLKANDGSVPTQCQVLRNTFFECKRSLLDARQRFRGRKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL54</accession>
    <name>A0A6P7GL54_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="5 13">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114343753</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_028150394.1">
        <property type="nucleotide sequence ID" value="XM_028294593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL54"/>
    <dbReference type="FunCoup" id="A0A6P7GL54">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641524.1">
        <property type="protein sequence ID" value="XP_050497481.1"/>
        <property type="gene ID" value="LOC126878674"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GL54"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000013">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="225"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028150394.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="60970" checksum="3C48B13BC8ABF8D8" modified="2020-12-02" version="1">MFRRQPMSEFEESKSAELCLSLYRDSLKSKDMDHDGTHFDGQYPHVFVILGASGDLAKKKIYPTLWWLYRDNVLPVNTIFYGYARSKITLSEVRQKCSPWMDVKPEEKEKYEEFWKLNHYMSGQYTSRTDFELLNKEVEKFEKGPVANRLFYLALPPSVYEDVTVHIKNNCMGQKGWTRIIIEKPFGRDLETSNKLSSHLSQLFTEQQLYRIDHYLGKEMVQNLMTLRFGNRIFNPTWNSDHIASIQINCKEPFGTEGRGGYFDEFGIIRDVMQNHILQILALVAMEKPASVQPDDIRNEKVKVLKSIAPIKLKDVVLGQYVGNPDGQGNAKLGYLDDPSVPKDSVTPTYALAVVHINNERWDGVPFILKCGKALNERKAEVRIQFKNVPGDIFDGKPKRNELVIRVQPGEALYVKLMVKTPGMAFDMEETELDLTYSNRYANVKLPEAYERLILDVFCGSQMHFVRADELTEAWRIFTPLLHYIEKERVKPVPYVYGSRGPKEADELLYNNNFKYTGSYKWKPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLN5</accession>
    <name>A0A6P7GLN5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114340311</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028146852.1">
        <property type="nucleotide sequence ID" value="XM_028291051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GLN5"/>
    <dbReference type="FunCoup" id="A0A6P7GLN5">
        <property type="interactions" value="2047"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291051.2">
        <property type="protein sequence ID" value="XP_028146852.1"/>
        <property type="gene ID" value="LOC114340311"/>
    </dbReference>
    <dbReference type="GeneID" id="114340311"/>
    <dbReference type="KEGG" id="dvv:114340311"/>
    <dbReference type="CTD" id="7317"/>
    <dbReference type="InParanoid" id="A0A6P7GLN5"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="908"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028146852.1"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115480" checksum="71D627EE33B3503A" modified="2020-12-02" version="1">MSSGSLADNSIDPPAKKRKLESKIATLEMANNEASGSSTSDIDEGLYSRQLYVLGHEAMRRMANSDVLISGLGGLGVEVAKNVILGGVKSVTLHDEALCTIKDLSSQFYLTEGDIGKNRAEACCKQLSELNTYVPTKSYTGPLDEAFILKFSAVVLTTSNREEQLRISEITHENNIALIIADTKGLFAQVFCDFGKSFTVVDVNGEPLVSAMIADISNDVESVVTCIDDTRHGMEDGDYVTFSEVQGMTELNNCEPIKIKVLGPYTFSIGDTTKFSKYTRGGIVSQVKMPKHLEFKSFKDSLENPEIPITDYSKMDFPTQLHLAFTTLHKFVEKSARLPKPWNNEDATEFVNLAKSLAAKGDSEEVNVDLLDTFAKVSAGDLNPINATIGGIVAQEVMKACSGKFHPIFQWFYYDAIECLPQDKSEITEELAAPTGSRYDGQVAVFGKEFQKKLASLKYFIVGAGAIGCELLKNFAMMGVGTQGEVTVTDMDLIEKSNLNRQFLFRPHNVQQPKSATAAKVIKKMNPDINVVAHENRVGPETESVYNDDFFEKLDGVANALDNVDARIYMDRRCVYYRKPLLESGTLGTKGNTQVVAPFLSESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDMFEGLFKQNAENASLYITDPDFLDRTVKLPGVQPLEVLESVKAALIDERPKDLNDCIAWARNHWQEQYSNQIRQLLFNFPPDQLTSTGQLFWSGPKRCPEALTFDVNDPLHLDYVIAAANLKAEVYGIPTSRNREQIAEVVMQVNVPEFIPKSGVKIAVTDSQMAMNGNNVDLDRVSQIKEELPSVAELGGLRLTPLEFEKDDDTNFHMDFIVAASNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVVAGMVCLELYKLTRSYTSLTPFKNNFINLALPFFSCSEPIAAQQMEYCGNKWTLWDRFDVQGEMTLSEFLEYFKEKHGLEITMLSQGVCMLYSFFMAKAKAQERFGLSMSEVVRRVSKKKIEPHVKALVFELCCNDSTGEDVEVPYVKYNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GN04</accession>
    <name>A0A6P7GN04_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rhomboid-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114344395</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151024.1">
        <property type="nucleotide sequence ID" value="XM_028295223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GN04"/>
    <dbReference type="FunCoup" id="A0A6P7GN04">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645761.1">
        <property type="protein sequence ID" value="XP_050501718.1"/>
        <property type="gene ID" value="LOC126881476"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GN04"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000024">
        <property type="entry name" value="Blast:Protein rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017213">
        <property type="entry name" value="Peptidase_S54_rhomboid_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF8">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037470">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037470-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028151024.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="41331" checksum="A407E277A2327153" modified="2020-12-02" version="1">MGDNVQIPLKSKEFYKAIFNKYDRNRDGFISIRELTDIIESREYEEDIPQHCIKKILGMHDRNLDKKLDFEEFYEMINNPDLNHVFGHYITRYINWVVPRRQLPRIPTTVTDGLYEEEYSCYPPAVGMIIISLIEIIFFCVDEATEYESTKYASGPCATLFIYEPSRRREVWRYMTYMFVHVGVFHLLVNLLVQVLLGIPLEMVHQWWRVLIVYLSGVLAGSLGTSIMDPTVKLAGASGGVYSLVTAHIASIVMNWKEMSFPIAQLLVFLVIAGTDIGTSIYNRYVLDINEHIGYAAHFAGGLAGLLVGINVLRNLSVTRTERIIWWISMITFGLLMGICIIWNLAWSSYFPDERYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR28</accession>
    <name>A0A6P7GR28_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114341884</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148497.1">
        <property type="nucleotide sequence ID" value="XM_028292696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR28"/>
    <dbReference type="FunCoup" id="A0A6P7GR28">
        <property type="interactions" value="1346"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292696.2">
        <property type="protein sequence ID" value="XP_028148497.1"/>
        <property type="gene ID" value="LOC114341884"/>
    </dbReference>
    <dbReference type="GeneID" id="114341884"/>
    <dbReference type="KEGG" id="dvv:114341884"/>
    <dbReference type="InParanoid" id="A0A6P7GR28"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602:SF4">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028148497.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37925" checksum="DBB4B43501FE2442" modified="2020-12-02" version="1">MDELLANSALEAEKFKPTVVNKLIDLNYDLGSLLAQDTNEFDTNLLRRQKEDYLLNLARDNTQLLLNQIWDLTTERLEEAIVVKLPLQITLLPRMKPLPKPKPLTKWEQFAKTKGIQKKKKSKLSWDQQLKKWVPLYGFKRTQAEKEKDWVLEVPANADPMEDQFQKKAQAKGERVAKNELQRLRNIAKTRKIKVPRVGVTNPEVSTAKDLQAAVTIAKASTASLGKFQRELPKEKEARGISAITPGVSRKRKLAPVSGDTERKETLAIVDSILNKRPKLDIEKAVSRHVNNEVGGSSNQGRSESRKKSNSSAKNKKPKGKGGQRKGGKSGGGRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSD9</accession>
    <name>A0A6P7GSD9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114342386</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148987.1">
        <property type="nucleotide sequence ID" value="XM_028293186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSD9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293186.2">
        <property type="protein sequence ID" value="XP_028148987.1"/>
        <property type="gene ID" value="LOC114342386"/>
    </dbReference>
    <dbReference type="GeneID" id="114342386"/>
    <dbReference type="KEGG" id="dvv:114342386"/>
    <dbReference type="InParanoid" id="A0A6P7GSD9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002104">
        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002110">
        <property type="entry name" value="Zinc finger protein 1053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000204">
        <property type="entry name" value="Zinc finger protein 331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001177">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000161">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001573">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028148987.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="81312" checksum="264ADF7ADC6C2C99" modified="2020-12-02" version="1">MEVKQEVSEHRYKIEIDNNGVNDALLDTVKTEIKEEPQTEVTHDSFDYLNLEEFPLKTELKYDEDKLCPLEVKESVIYEDTATDECNELKDHVISKQLTQCTTTVKKENAVEKPFECEICTKQFSYRSHLKIHMITHTGEKPFSCGVCTKQFTQSSALKQHMKIHTTGKSKFECDICTKQFSNKSYLKLHMKLHTGENPFVCEVCTKQFTQSSSLKVHMAMHTGESQFECEVCAKQFSHSSHLKLHMIKHSTEKQFECEICTKQFSHYSSLNMHKKIHTGDNLFGCEICTKQFARSQDLTRHLRIHNGEKLFVCNICSKQFSQSAHLKSHMLTHTGEKPFECEVCSKQFTQSSSLKQHMIRHTGEGQFKCEICTKQFSRSANLKIHMITHTGEKPFTCEVCAKQFTQNSSLKTHMKMHCEESKFECEICTKQFSQSAHLKAHMITHTDEKPFECEVCTKQFTQSSSLKKHMERHTGEGQFECEICSKRFSRNHDLTRHLRIHNTEKLFVCNLCTKQFSQSDYLKTHMKTHTDEKPFECEICSKQFKQNCSLKLHKKVHTGDNLFGCEICTKQFARSKDLTRHLRIHSGEKLFSCKICNKQFSQSAHLKGHMLTHTGEKPFKCEVCIKAFTQSSALKQHIKRHTGELKVKCEICTKQFSQSAHLKVHMITHTGEKPFTCEVCAKQFTQNSSLKQHMKRHAGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1C9</accession>
    <name>A0A6P7H1C9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type lectin 37Db-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114344899</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151523.1">
        <property type="nucleotide sequence ID" value="XM_028295722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1C9"/>
    <dbReference type="FunCoup" id="A0A6P7H1C9">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659779.1">
        <property type="protein sequence ID" value="XP_050515736.1"/>
        <property type="gene ID" value="LOC126890661"/>
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    <dbReference type="InParanoid" id="A0A6P7H1C9"/>
    <dbReference type="OrthoDB" id="6746664at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF465">
        <property type="entry name" value="AT17652P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
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    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027789434" evidence="2">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028151523.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20709" checksum="85B0785428C1CA0B" modified="2020-12-02" version="1">MYFKLILVLLVCNVVKLSVQGGREFVSPVLQSPSRGRDSNWLSYGGKIYYKQIVFKANYFKATQFCRQQGMQLLSISNHIENERLGKFILDTGTLTGLYWTSGTKLVGDDQWVWLSTGQRISYTNWGAGEPSGKTPDQKSEENCLVFDYFKGNNAWNDMNCHWDQYFICESVSECDKTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H4S5</accession>
    <name>A0A6P7H4S5_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114346087</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114346087</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152678.1">
        <property type="nucleotide sequence ID" value="XM_028296877.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A6P7H4S5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050660672.1">
        <property type="protein sequence ID" value="XP_050516629.1"/>
        <property type="gene ID" value="LOC126891495"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
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    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028152678.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="18090" checksum="6E6180809FB1AB7A" modified="2020-12-02" version="1">MEEIIIYHENDVQEASAIVKTVDYVVWTTNQTKVLIYLYRKYKPKVGTLQIRNLKKLWELIANEINKNLLLNVSPSHSENKWRVLERGYKKFIDNQNKTGRGRKFFEFKDEIDSIFKKRGNVHPEILASTSKVIKRRLELKKWRILRVQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAR3</accession>
    <name>A0ABM5IAR3_DIAVI</name>
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        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128742.2">
        <property type="nucleotide sequence ID" value="XM_028272941.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272941.2">
        <property type="protein sequence ID" value="XP_028128742.2"/>
        <property type="gene ID" value="LOC114325016"/>
    </dbReference>
    <dbReference type="GeneID" id="114325016"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128742.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25239" checksum="0088A90892BD8392" modified="2025-10-08" version="1">MCPKVFSYPKGALEHENVHTGAKPFSCEHCGCSYPLSRTLTDHIHRKHSKTIPEEKMHNCIVCSKEYKSESGLNRHYASNHQELGYDYRIGCDICEETFCSIKQLIRHKLTHPGFKPYECDTCNKGFSSKGQLKTHQRVHTGEKPYVCNYCDKRFAQHAPYLYHLKTHTGEKAYFCVNCKRGFIAPANLRNHMNKCHVKYETTNEIYIKSEPFQLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEY5</accession>
    <name>A0ABM5IEY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131320.2">
        <property type="nucleotide sequence ID" value="XM_028275519.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275519.2">
        <property type="protein sequence ID" value="XP_028131320.2"/>
        <property type="gene ID" value="LOC114327024"/>
    </dbReference>
    <dbReference type="GeneID" id="114327024"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131320.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="649" mass="77650" checksum="3B54E232007EFDA4" modified="2025-10-08" version="1">MAQSGPKDDRNLLSNTVKTESLNDDVSTPDNNFSGKAIDFQFSIQPKVEQCEIKDEVEELEFVGEVIEFSENELSDLEESQEPESKESYLCEQCNVESCYKKHDLHADFIRITTKPLNQSNPYECAICSIKILNPTIALFHLSLHDKDSFRCYKCDCILLEFSDFLEHIEKLHSKDKDYYRCVECNFVTFWHVQYITHKNKFHKPKVFHKCKLCDELWPTRNHNLHEKMLHIRSKYGRNPYVCKTCEIELVDPDEIYDHLKIHGDIGIFCSFCAFTSENLKDLDSHKKDKHAEEIEKQRILRESCKEYMGNDNDVICELCNRYWPDKYHKNHERMILIEKQVTEDKPYKCKTCNEKTCDLREVYKHVNRYCMYTIKCPFCSKKFRVRTVLDNHIIREHPDKEHVMGNRLLKCKLCEYTTAGNTNFKNHLNTHKSMEDRQQYNCNECDFTTTLSTYLKRHRLSKHPVESDKRYTCDKCSYSSHLISRIKRHFKIHVTNEALKCDICNALYTRENSLQRHKAKHFQEEPKKKEYVCEICAKVYRFKVSLVSHLYHVHQQGEMKVYMCYSCKYKSYNKCKFILHTRIHMKQQEFFYCANWEYKTIRKMNLKQHMVKHADSSKMQLYKCKMCSFKTKRPHTLRNHVKYTHGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INJ8</accession>
    <name>A0ABM5INJ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137380.2">
        <property type="nucleotide sequence ID" value="XM_028281579.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281579.2">
        <property type="protein sequence ID" value="XP_028137380.2"/>
        <property type="gene ID" value="LOC114331892"/>
    </dbReference>
    <dbReference type="GeneID" id="114331892"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="11"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137380.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="460" mass="50888" checksum="BA11BF751E4C399E" modified="2025-10-08" version="1">MDVSRQNWFLYFCAFGVNVVLVCFGSMLVWTSPVIPKLQSNDTLVNPIGRPLTVWELSILTATYPLGLVTGTIVIGKVPDLIGRKWTLIWISIGALFSCIGLYLATNIYTFFIFKYTVSVSLGGGPILVPMYTSEIAEDHNRGRLGFFMTFGIIFGELYGNVVGAVTSVSTFSLLCGIPAVLSLVCCMYLPESPEYLLMKGRKNEAILALKKLRKHKPITEIENECLDTQNMVKSNCSTKSSFLERLQEDKGIRKGFYLAASVLIIQNSAGPIIVAAFLNPILSEAAPELNGDILSVIVVSLKFSAAFVGTYIVDRVGRRVLILIALFVCGTSMFGLGLYFYFQHNHYEIPFAVKMVPVLCLICFVIVFSIGLSCIPYTLVAELLPSDLRSLGSSICQFLGDIFSISTAFAYPLAANYFGEHYCMFYFCIVNLSGCIFLYFFLPETKGKSFLEITNILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPG4</accession>
    <name>A0ABM5IPG4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138076.2">
        <property type="nucleotide sequence ID" value="XM_028282275.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282275.2">
        <property type="protein sequence ID" value="XP_028138076.2"/>
        <property type="gene ID" value="LOC114332479"/>
    </dbReference>
    <dbReference type="GeneID" id="114332479"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138076.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="128" mass="15342" checksum="E57A981BA15C847E" modified="2025-10-08" version="1">MSEKWISKILGDPYRPLFTHPTKNNPRSLKFYGRNYSVIPIVMLAIADMCWLTFCSVQGFIRTNVVLTRWDRTQRDMIDLLIKPRNRKFLTFNQTFPVQQDLYDTYKKMEEAEQEECEEDSIPPRQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWF5</accession>
    <name>A0ABM5IWF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145335.2">
        <property type="nucleotide sequence ID" value="XM_028289534.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289534.2">
        <property type="protein sequence ID" value="XP_028145335.2"/>
        <property type="gene ID" value="LOC114338902"/>
    </dbReference>
    <dbReference type="GeneID" id="114338902"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF27">
        <property type="entry name" value="ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="534"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="536"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="638"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145335.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="100346" checksum="98F03E3F3682CC2D" modified="2025-10-08" version="1">MVARSESMFGCYDSYSYRLWSLANVWNTCQPSPLTNGTIKEEDLTPTTPEYFIKCPQCQKGCQTFQALKEHMECAHMDLSIVSEASGMTVPNAVSPTPSMAGAGGPFGCSQCTTTFSSKDQLEKHELLHSPNAQVSCKVCNKTFANVYRLQRHMISHDESAVLRKFKCTECDKAFKFKHHLKEHIRIHSGEKPFECANCGKRFSHSGSYSSHMTSKKCLVINVKLGRTRAPPNSSLLDKNTQNLRGPKRPNISPINNNITTSPNHNSYLPILPKYPEAAAAFLQSSLAGNPSIPPFYLAPPSLLNTHPISHYSMPSLSHLLEQLQQQHQQQQQSQSPMRPSYIENCDSPRQTETNPNFENSSNHSENNDHRPPSNASESGDLVMDEDAEIDNETKTQNENQTNTGDLEAVKRILETVNATVTKELLQANMQKITSDSSSECHSLASVHSPKPTPKCSTCKKLFDTQQQLEQHECEDIKSEGLAAKLEGAFTTKSEDAQNGSISGEDQEYERNYNTNDELDSESFATTDHVSEDGRKVRVRSLISDEQLKVLKDNYKMNPRPKREDLEKIASSIGFPVRVVQVWFQNTRARDRREGKLIQVPYSPLQSSPCFSLPPKPPVSVSPNQYTCEQPLDLSIKRDVTSPESSPSCSPCRPSSDTNYEVVNLSRKTSRSPTPYLPFQNHYHNSNSSDPRQSPSPLELNSSRLAQILAQPSHKLSLPGMGLVPMDQLMQFGGTDLPSLSQLISSRLSNMSPSEKRAWVEGRDLANDMTEDELSHATKRSKISQFVFKSLGSPVLGNQEVEAEGQFTCDQCDKAFSKQSSLARHKYEHSGQRPHKCDECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IY10</accession>
    <name>A0ABM5IY10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148391.2">
        <property type="nucleotide sequence ID" value="XM_028292590.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292590.2">
        <property type="protein sequence ID" value="XP_028148391.2"/>
        <property type="gene ID" value="LOC114341780"/>
    </dbReference>
    <dbReference type="GeneID" id="114341780"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148391.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23059" checksum="211E634EDF76D95F" modified="2025-10-08" version="1">MEGRKQPGSFWRKRKQEKQERQNKILKGIPKMTAFFTPDGNQEDNTTNISQPGSSSSATSDKYIHIQPHELILETSELVPEPEHLVSPVSKVLEYEEATTSNSDPKQDLLNFKDPALWQDSHNYAEMILEKWVEQNLTDMDFSMSKRNFGEQHRYAGKQIFYKRLVNGEVVRRDWAIYSESTGNILCLYCVLFGNKKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZX4</accession>
    <name>A0ABM5IZX4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vang-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Vang family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154412.2">
        <property type="nucleotide sequence ID" value="XM_028298611.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298611.2">
        <property type="protein sequence ID" value="XP_028154412.2"/>
        <property type="gene ID" value="LOC114347963"/>
    </dbReference>
    <dbReference type="GeneID" id="114347963"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009539">
        <property type="entry name" value="VANGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20886">
        <property type="entry name" value="VANG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06638">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007991">
        <property type="entry name" value="Strabismus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154412.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="557" mass="63145" checksum="36E8F3434C7EA209" modified="2025-10-08" version="1">MGNETARDMETESVKSENSSKSRRSRSHRDRTSNYRHHSHRSTRSSKSRRNDDMAPFQTAVTMTPDNRDGQEVIEVQILPQDDNWGENTTAITGNTSEQSGSAEDICNWPGEPDTGLGFVCQRYMGTSITYILSLAAFSSPIAMVLLPKMGFFPDLSARIGLADSTKLLACGAECKGQLVSLAFKMVILAIGAWAVFLRKPQATLPRFFLFRAGILALLLVCTFAYWLFYIVQVTETARAATTPEETVDYKALVAYASSLTDTLLFIHYLAVVLVEIRHLQPMYYIKIVRSPDGASCAYGIGQLSIQRAAVWVLEKYYTEFPIYNPYLERIPVSKSRKTSSSFKFYEVDGINSSQIQQSQSRAMLAAHARRRDSSHNERFYEEHEYDRRVKKRRARLITAAEEAFTHIKRLHNDQVSSIPMDSHEAAQAIFPSMARALQKYLRVTRQQPRHSVDSILNHLANCLSNDLTPKAFLEPYLVSEPVLQNDKEKKDVQTWALICEEILTRPIGDGIFFQLRQNDVSLLCNIKKIPHFNVTEEVVDPKSNKFVLRLNSETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J045</accession>
    <name>A0ABM5J045_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155241.2">
        <property type="nucleotide sequence ID" value="XM_028299440.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299440.2">
        <property type="protein sequence ID" value="XP_028155241.2"/>
        <property type="gene ID" value="LOC114348999"/>
    </dbReference>
    <dbReference type="GeneID" id="114348999"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045278522" evidence="1">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155241.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="355" mass="40042" checksum="E44A56751B8DCB5B" modified="2025-10-08" version="1">MELSVLMTILILGMHQITAKTSPVIVSHDGKTRHSQKQNAVSTTAKPETRYQIVQKYVQRAQPEKTPSHYTQSVAAVPQQLQQVTVQPFQLHQQVVPIQTQLHPQSQQQLLQLIQRVLYSTQQNNQPTAMIIIAQPTYIPANVVYGNAAQQLLNYPQARFQYSPVTSHTQTLQHYVPQTQAVQVTQPIQSYPILPAPAQYQTKMVQLPTSQTTHMSPVQTAEAYSQQVPLQLSQIAQMTQLSAQQYYPQSQYVQAQVQGQMQTQAQAQLQVEPKENQVEYPSSIPPIITGFENFTPEQQEKIKAQLSAHFGAPLKPLNIGRKDNKYQLNTDEFIPSPQVKTERSSNVMSISKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHA0</accession>
    <name>A0ABM5JHA0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase from transposon X-element</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497314.1">
        <property type="nucleotide sequence ID" value="XM_050641357.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641357.1">
        <property type="protein sequence ID" value="XP_050497314.1"/>
        <property type="gene ID" value="LOC126878567"/>
    </dbReference>
    <dbReference type="GeneID" id="126878567"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="26576" checksum="2D79A25E116AC5E3" modified="2025-10-08" version="1">MQKMRNQALNRYRRSRNPEHWNYYKQIRNLITSTIRREKKIYLNNKLQNCNIKEKWNELRKINVLNRKQNHIPDNLKDVNKLNQHFTAACSINQQPSNELLSFYRNHSMPVQEPFRFNTVSMEDVADIILSVKSKAFGQDDLNITLIQLCCPFIVPFITHIVNSCIIEFYFPASWKRAKIIPLPKIKNPTEFNHLRCISILPTFSKIIEKIIEKQMSNFLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHA1</accession>
    <name>A0ABM5JHA1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497316.1">
        <property type="nucleotide sequence ID" value="XM_050641359.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641359.1">
        <property type="protein sequence ID" value="XP_050497316.1"/>
        <property type="gene ID" value="LOC126878442"/>
    </dbReference>
    <dbReference type="GeneID" id="126878442"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="4">
        <location>
            <begin position="219"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57785" checksum="71E79B87BFE7EC7C" modified="2025-10-08" version="1">MSYEGSTHNVELSPAFIEHLQVDFKSLSSESKKKYPQVKEACEEAILKLKGAQSSPQTSIYYVVNQIIYPLSQGCETKDVKIIRLCLQIMQKLITHQLVDQKGALYITDTLWSLMESGIEEVKILQTVTLLLTTNTVVHGETLARTLVLCFRLHFAKNSTTINTAGATVRQLVYLVFERVVSEDEQLSKSENIPQRTTANFEDLKVPSGNPPKGLPPCAGDAFLLFQDLVQLVNADQPFWLIGMTEMTRTFGLELLESVLTQFSSVFFKNTEFSFLLKERVCALVIKLFSPNIKYRSNVPSSLQQATPFEKPYFPISMRLLRVVSILIQKYHSLLVTECEIFLSLIVKFLDPDKPTWQRSLALEVLHKMTIQPELLNSFCQCYDLNRHTTSIFQDIVNSLGAYVQSLFVSPQLQMGAGMQVGQGQAPMYLGVSAGPGVSPQPGFLLRGVWLPIVTTFPTGQTKSTYLEMLDKIEPPIVPDGYGISVAYACLMEIIRSLQITINPQQQPDEPVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHN1</accession>
    <name>A0ABM5JHN1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497447.1">
        <property type="nucleotide sequence ID" value="XM_050641490.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641490.1">
        <property type="protein sequence ID" value="XP_050497447.1"/>
        <property type="gene ID" value="LOC114331646"/>
    </dbReference>
    <dbReference type="GeneID" id="114331646"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="346" mass="38735" checksum="D9E77B215B0D26A1" modified="2025-10-08" version="1">MDSLVTIYGCLFFVGVIGNGTLAVNLYWGRGSKSPLLLGLIIADFFVCCLSGPITAATYSMPPDSPVLIVAAQYLQSFPVTASTLSMMVISVDRYFTVKNYRPIGQVATRRQVLSFTVAATWLSAAFLASFQIISRYKHPWRKGLTISRIALVHIIPAFTVMMSHLGVHAKLTALSLTARAKHGELPLPIPLMRRPTHVIIVAGMPKGRKQMSISSAQDEIEETPPPTSSLRSRRRLANCLLCLSLFFILCWFPYVVCQFCEEFMTGVTPEYVQQLTLFLGHMHSAIGPILYWSMNHKWPKGPCSRIRRLTIYRSASSTNEAALGPFNPRLVRPPPYRRRSSQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK62</accession>
    <name>A0ABM5JK62_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498326.1">
        <property type="nucleotide sequence ID" value="XM_050642369.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642369.1">
        <property type="protein sequence ID" value="XP_050498326.1"/>
        <property type="gene ID" value="LOC114333104"/>
    </dbReference>
    <dbReference type="GeneID" id="114333104"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF93">
        <property type="entry name" value="MITOCHONDRIAL DISAGGREGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="286"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="610" mass="69711" checksum="A6B7B95668714AEE" modified="2025-10-08" version="1">MIKTNLCKLYKTLTILRLRKLHRYPLQITASKQFPIVPISTKYEKNDDFNFPFKVPWGIFSLVASLVFCEAGRLDRDEQRLFKACLFGLTHELERLAKQGVDLNRRHHLGWTPLLVATVNGRYEIVEYLLKNQADPNLSDNYANPNRTANEKGMHPIEVLMARDEEFSSSLNNKATFLGFTPLHYAVLTDNLDITKLLIKYGANPILQNDMGHTPLTYAKDPEIKQYLEKEMSAFEEKQKEKELEERRRYPLEERLKKHIVGQEGAIAIVSATVRRKENGWADDDHPLVFLFLGSSGIGKTELAKQLANYMHKGQSQAFIRLDMSEYQEKHEVAKLIGAPPGYIGHDEGGQLTKKLKKCPNAVVLFDEVDKAHPDVLTVLLQLFDEGRLTDGQGKTIECKDAIFIMTSNLASDEIANHGLRLRQEVEKLKTDRLAIPDSAEAEQKISDTITVSRKFKDEVVKPILKRHFKRDEFLGRINEIVYFLPFSRNELIQLVTREMQLWAQKAKEKHKIEISWDRSVESALADGYDVSYGARSIKYEVERRVVNQLAAAHEQGFIGKGCAVQVCASWPENSDCAEIKLKVKRSGLKDFVDLDHSRLSLKNLSSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKF6</accession>
    <name>A0ABM5JKF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498423.1">
        <property type="nucleotide sequence ID" value="XM_050642466.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642466.1">
        <property type="protein sequence ID" value="XP_050498423.1"/>
        <property type="gene ID" value="LOC126879447"/>
    </dbReference>
    <dbReference type="GeneID" id="126879447"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF72">
        <property type="entry name" value="FI21449P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="231"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="644" mass="74840" checksum="0FFA9B27F4CE3FBC" modified="2025-10-08" version="1">MVIFKNRGIIMNTKLYYILACLANYFLLCSTAVSDEEYGLMPDIFQVDDFDSCMMLKDRALYCEITYEFTPINPNNPPDIWKTIKEVSSSELHYRHDLLRLFVCVPKSCPMTKISNSTNEKLRKDLNDCIDERHRSLGFKGIVKINACKRVNPIYEVDTGDWLFAIAFFSYMGFVLLCTMLEYKNKEDEGFYKNTSTTGKIILSFSIMSNWNKLKTVPTGPKFERLRPVQGLRVYLSILVILVHTGLSQVAIPVTNTKFLENINDSPDFLNEIPKRGIFLLSFFFLMSAWMVIMPLLAKRDQNEDLSVKFVIHSIIKRYIRLLPTVAVIVGFYATWFRHIPFGPFFRGLCEESERCRQNWWPIFLFIQNHYDRYFMCHIVSWYLAVEMQYYIITLFLFTFILKRNISIPLTVGVLLTLNVIWDFLDHWRHGYPSILSGRPEEIYSIVFNQKPQWHDHFANYHGNASGYILGLGFGYVFYKYSNKPIFDTQWKKIVWAILSFGPVFLTTNLPLYYDVDATPAHSAVWVALTKPLFSLGMGFMVLGLAEGLGGPLRSILNWSPLYVLGKLSFCLYIGHTVYQNIRIGLMRTPEYPSYFNLVKYLSSDVLIGFLGALWLSLFFEMPFNELVNRLSKGSKRPVEKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JN87</accession>
    <name>A0ABM5JN87_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499401.1">
        <property type="nucleotide sequence ID" value="XM_050643444.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643444.1">
        <property type="protein sequence ID" value="XP_050499401.1"/>
        <property type="gene ID" value="LOC114330552"/>
    </dbReference>
    <dbReference type="GeneID" id="114330552"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36914:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36914">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047434051" evidence="1">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="472" mass="48173" checksum="DBE1199CC4B33F63" modified="2025-10-08" version="1">MKFLVLFALVLYCCSEVLCNNDKPQCEGIQCDMPNCPFGDILKYPGEEDTACCPYCEHNPNCEVCGDLPRCAPGSSLRLKQNSCCPSCEPFGGPCDGVQCSPPNCGLGARPVVKPGDCCATCQGFGNPKCEGIQCDVPLCPPGSILKLKDNACCPSCEPSGGSCDGVQCSPPNCGLGALPVVKPGDCCSTCQGFGNPKCEGIQCDVPLCRPGSILKLKEGACCPSCEPFGGPCDGVQCNPPNCGLGALPVVKPGDCCATCQGFGNPKCKGIQCDVPLCRPGSILKLKEGACCPSCEPFGGPCDGVQCSPPNCGLGALPVVKPGDCCATCQGFGNPKCEGIQCDVPLCLPGSILKLKEGACCPSCEPFGGPCDGVQCNPPNCGLGALPVVKPGDCCATCQGFGNPKCKGIQCDVPLCRPGSILKLKEGACCPSCEPFGNPRCAGIQCGVPLCPAGTVLRLVSGDCCPSCQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRB3</accession>
    <name>A0ABM5JRB3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500474.1">
        <property type="nucleotide sequence ID" value="XM_050644517.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500475.1">
        <property type="nucleotide sequence ID" value="XM_050644518.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500476.1">
        <property type="nucleotide sequence ID" value="XM_050644519.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500477.1">
        <property type="nucleotide sequence ID" value="XM_050644520.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644517.1">
        <property type="protein sequence ID" value="XP_050500474.1"/>
        <property type="gene ID" value="LOC126880568"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644518.1">
        <property type="protein sequence ID" value="XP_050500475.1"/>
        <property type="gene ID" value="LOC126880568"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644519.1">
        <property type="protein sequence ID" value="XP_050500476.1"/>
        <property type="gene ID" value="LOC126880568"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644520.1">
        <property type="protein sequence ID" value="XP_050500477.1"/>
        <property type="gene ID" value="LOC126880568"/>
    </dbReference>
    <dbReference type="GeneID" id="126880568"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028408" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="56"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="310" mass="34196" checksum="35D42B8E0974D8EA" modified="2025-10-08" version="1">MKSINLLICVLFVYLNIAEGISEDSSSAAVANEICKSYTEDAKKNHICPVPQETRLIGGILAEKGEFPHMVQLAYSKRNTTEYLCSGFIISKNYVLTAAHCVNGGGGTNKPHYLRAGVTDVNDVSNEQVRSIDSIIIHPEFKRPPIYHDIALIKVTEDFNFNKFVSPICLYTNNENPDGEGVHPGWGPTGDDFALEKQPHMIRLSLNFDSNESCNSTFFRIAKSVLPEGIAKNKIVCAGGKTGGCQIDSGSPLQIYRKDGKEKPCMYDAVGISSFGVKVCGKEVFPTAFTRISHYIKWIQVNVWPQLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRV7</accession>
    <name>A0ABM5JRV7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500672.1">
        <property type="nucleotide sequence ID" value="XM_050644715.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644715.1">
        <property type="protein sequence ID" value="XP_050500672.1"/>
        <property type="gene ID" value="LOC126880662"/>
    </dbReference>
    <dbReference type="GeneID" id="126880662"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="145949" checksum="A64B035FB463FFAC" modified="2025-10-08" version="1">MIHDRMRFAKTIGEKHHLEAQMRQVKTLRNQLKAEQKKGAGLKTLPETAKRRVQWDDSVSTFNSRIQTGVISNLKHKDPGSFLVDCKALFKRRIHNVLKNNAAVKVNIAFGGEFEIAQGEKMINETKYFTTSNSAIYRDTNLDEWFKKKVVEPISRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIELPPQIKRKQACINVKNDDEACFAWAVISALYPCRSNSDLMSSYPHYSQVLKLKGIQWSMTFKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTKNKKDKHVNMLLIQDNYDDQGPVRYHYVWIKNLSRLLSKQLSKCDGTKYFCDGCLHYFRSQEKMNVHKTCCNGRSDVICDRCLQPFSSYTQLEAHINDCERINETAIKMPEESQKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVGYYFKCSYDNSLSFYKSYRGKDCMKWFADELNQLAEDVSTVFMCPFDINMTFQQESDFQSATHCHICEQRFSPSDKKIRDHNHLIPENNCRFAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVTDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSQYVFLPEEQFNLLTAKGIMPYDYIDSFDRFIETCLPSIESFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLADVFERFRSSCLETYNLDPAHYFTLPGFTWDAMLKYTKQELELLTDPDMHLFVERGIRGGLSQVCSKRRVHANNKYMVSYDPSKTDSYLMYFDVNNQYGWAMSQYLPFGGFEWTDTNIDVLSIPDDSSEGCILEVDLEYPQHLHDRHKDIPFCPQSLNPKTMKPPKRPRELTKLMATLHDKERYVIHYRALKQALAHGLILKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTLECVRRRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLIAVEMHRAEIWLVKPIYVGMSILDLAKTTIYDFQYGYLASRFGENFSTCYTDTDSVIVEIREKDPYEAMIYDCYKYFDTSDYPKDNIYNIPLVNKKVLGIMKDENNGCIMTDYIGLRSKLYTTKAATTDNDIEKLRGKLKEQEYEDDEIDNIIRNYGVTKKAKGVKKSVVNTKITFEDYVECLDTFTTKTATQNLIRSDKHQVYSITQSKIALSSNDDKRQHIQGSYDTLPFGHYLIDTLEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS01</accession>
    <name>A0ABM5JS01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeotic protein ultrabithorax-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500716.1">
        <property type="nucleotide sequence ID" value="XM_050644759.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644759.1">
        <property type="protein sequence ID" value="XP_050500716.1"/>
        <property type="gene ID" value="LOC114327657"/>
    </dbReference>
    <dbReference type="GeneID" id="114327657"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="23883" checksum="A79F489972DE042A" modified="2025-10-08" version="1">MNSYFEQSGFYGGHHHQGSGSVTGAHHHDHQSAAAAAAYRSFPLSLGMSPYASSQHHHAHSLHQARPPQDSPYDASVAAACKLYSSSSDGQQNSVNYSSSTTKSDCSKGNADQNGYASVVAAAAVKDVWQSATSGAGANLSNSLTGPVRPAACTPDSRVGYGSSVGLVGGDPSSSPGAATGGRTSNSLSSWNNPCSLNSSSSQPVGTQIHQQTNHTFYPWMAIADEFSNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT39</accession>
    <name>A0ABM5JT39_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501107.1">
        <property type="nucleotide sequence ID" value="XM_050645150.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645150.1">
        <property type="protein sequence ID" value="XP_050501107.1"/>
        <property type="gene ID" value="LOC126881106"/>
    </dbReference>
    <dbReference type="GeneID" id="126881106"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047394826" evidence="1">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="125" mass="13879" checksum="AAA4D6AA689FC239" modified="2025-10-08" version="1">MSKIFTFIVIAVAICIQSSRADDKPEGMDECLKKSGATVEDILARPNKNTNEIRCFRKCMLEKQGMIDGSGSIHKDLFDKAYPKAAAHFDDATIATLKACIGSIEKIFNCDDMVKVRECFKKAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTI0</accession>
    <name>A0ABM5JTI0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501249.1">
        <property type="nucleotide sequence ID" value="XM_050645292.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645292.1">
        <property type="protein sequence ID" value="XP_050501249.1"/>
        <property type="gene ID" value="LOC126881191"/>
    </dbReference>
    <dbReference type="GeneID" id="126881191"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="285"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="481" mass="55853" checksum="6720A4889AFCAFCD" modified="2025-10-08" version="1">MDSMPSTSGNCPSPPKKRGVNLGRHLSSNEKQFIINMYKQIKIDDPGMKITAMVAKIKQATGKFFRIPIVKIKDLLSNVLILGVANSTIYRTIKEYKQTGTVRCPKNIGGRPAVLSRYYDEKVKTSVRQIVHSFFFKNEMPTLNKILSEVNNRPDLPNMCRSTLYKFLKQINFKYLKRSRRSHLIERDDIIRWRRRYLTSIKEYRSQGKPIYYLDETWVNEGHTKENVWVDTDIKNRRQAFIEGLSTGLKNPSGKGKRLIVLHIGSELGFVNEGLLLFEGRKTEDYHEEMNASVFENWFSNILQKLPKNAVIVMDNAAYHSRKLEKIPTTSSKKKDMQEWLKIKNIPFNLEMVRSELLHLIRLNKNEYNMYVTDEMAKENGQIVLRLPPYHCELNPIEKIWAQVKNEVALRNTTYKLKEVKNLLLQALDNVTPTHWQNCVKHILKVEEKMCKLDGIMDSVIEPLIISIGNDDSDTSSSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUG9</accession>
    <name>A0ABM5JUG9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501585.1">
        <property type="nucleotide sequence ID" value="XM_050645628.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645628.1">
        <property type="protein sequence ID" value="XP_050501585.1"/>
        <property type="gene ID" value="LOC126881384"/>
    </dbReference>
    <dbReference type="GeneID" id="126881384"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045240000" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="62" mass="5139" checksum="860095135E172A5E" modified="2025-10-08" version="1">MRVVSAIVVFLCVVLLIIQTISAAPAPIPGGGGGGGCGGGGGGGSGGGGGGGGCGGGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVC5</accession>
    <name>A0ABM5JVC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501887.1">
        <property type="nucleotide sequence ID" value="XM_050645930.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645930.1">
        <property type="protein sequence ID" value="XP_050501887.1"/>
        <property type="gene ID" value="LOC126881584"/>
    </dbReference>
    <dbReference type="GeneID" id="126881584"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="398"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="465" mass="53496" checksum="6D35E6D8B79B0167" modified="2025-10-08" version="1">MTCARCGYGVLKAEDQIVMTKVWHKCCFRCCNCGNILSTSSARFFQGDLFCERCHGLVLNDLENFTSNPECRPHKAVSLPSCTCTDDEKQIKIKTVPSVNSHKPNDIEISAEAKQGVLEKTKSCSCPPDISEDRHNCCEFPLPREVANYLNRNGMKKKAIHEYHKTSNLAETPCSILRMGGRCPRITVRTLSPPRRGCCFMTQNSPPRLFVQCDRCTDSTPGPVGYCHSRRHSPHRRRKHSPSKRDPPCNCHLEPRYHRQIFRRSLPEQELYSNTDEASHDNCELCPGCKICCNYHKCPKCREYHRNNNDCPVFTKHSDYTEENHEEECPIFRNFPGHAEEKNDNEYPSGVQCLCCPIHNRKPYNNFENIDRNGNFCFCGNVMPCRCKISQVRDECTSNCVRCKRKVYAAEKIYISSGPFHTSCFSCYCCNKLLDVRHVYEHKGEIYCKNCYNSFTGNQYYGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYA9</accession>
    <name>A0ABM5JYA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050502926.1">
        <property type="nucleotide sequence ID" value="XM_050646969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646969.1">
        <property type="protein sequence ID" value="XP_050502926.1"/>
        <property type="gene ID" value="LOC126882124"/>
    </dbReference>
    <dbReference type="GeneID" id="126882124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="612"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="951" mass="108318" checksum="BAF73E9DA27F96B5" modified="2025-10-08" version="1">MDGQIGHINERDDLIESIKNKYKLLFDGNMCSPIKHFEVKFNIKDNVIPIFKKAYSMPYAIKPLVERKLDQMVQVGILKPVKHSEWASPIVVVAKKNTEDIRICTDFQVTVNKVLSVEQYPLPLPEDIFASLAGGKIFCCIDLSGAYQQLKVNEAFQKYLTINTHIGLFRFTRLTYGIASAPAIFQSIMDQILAGIPNVHCYLDDILISGTSIEHVSRLLEIVFNRLSSYNIKVNAQKCSFFKDQVEYLGHRIDKDGIHPTSDKLRAIKEAPEPKDITQLRSYLGLINYYSKFIPMLSGRLKPLYKLLEKNVKFNFNAECKAAFCLSKELIEANQVLAHYDPNKQIVVACDASSYGVGGVLSHRYSDGREKPIHFVSGTLSKAEQNYSQIEREALAIIFCIKKFHKYLYGRQFILVSDHKPLKVIFNPDRNISVMSASRIIRWNVILSAYDYKVEYRKGSQMYEADMLSRLPLSDPTEVDGYINSFNLTEELPLTFEDVAKVTKTDTVLVKVLDFVKTGWPSKITDPVMKPYFLKRHEMSVEENCLLVGSKVIVPTVLRNKILELIHENHTGMVRSKMLARSIVWWPGLQHDIEQMISSCEICQLSQNNSEKSLMPWPRTANVFERVHIDFFFFNNVSYLLLVDSKSKWIDVHVMVRGTNVTNTIEKLKLTFSIMGLPDIIVSDNGPPFNSNCFLKFCEINGIKVVKSPPYHPQSNGTAERHVQTVKVAFKKFLLEKSTLTVEQRLVNFLFTYRNTPCANTGVSPNEYIFKVKPKAVIDLIKPKKGNYCSYNKALDFKQIECFLVGEKVLVGRLGPYITDKWQEGSIIKRVSPVTYLVQVNDRVLYKHVNSIRKFSATTNIEQPSTSLTTNHGLRPAVVQENCNSEIVDPLSHQMTSVKIKETSPDSEGGLQFGSPVKTTDHSIPLETINPTGIELRRSNRVRHQPQRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZW1</accession>
    <name>A0ABM5JZW1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503478.1">
        <property type="nucleotide sequence ID" value="XM_050647521.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647521.1">
        <property type="protein sequence ID" value="XP_050503478.1"/>
        <property type="gene ID" value="LOC126882553"/>
    </dbReference>
    <dbReference type="GeneID" id="126882553"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047120788" evidence="2">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="474" mass="54586" checksum="B53CBBE36AFD7786" modified="2025-10-08" version="1">MIFIVIKLFFVFNIFQLIVATNSESGLLKYKTSIDKIGTDVENFIYDIAKEVAKKADSFINNEYDELTEENPTVENNIIKEEATTSATVNVIEDYTEEERIKRSIDDIQSEGSIIAAGEKPEVHQESNVVDHSVDGLKQELKKLTDLTVMLKEQQNILALLGEKGKFLNDNLQSNPQDMIHLLEQLEDQRRILKPTKENSKELKHLKVDIQEAIEALNKTSKGKDNEKDKELKLELEIKQQKEEIEMLKDLVEQILEKQDSFEEDKSSEEKRESEDDILGVSLFLQPLGNKTPTRERESNMKENVENKDREQFFNQKNPPGENKDQEKTRTQTTNVDNKATNEKSNVKSIPYGDSKLSLTKSNEKSTHYEEPTLPSGKSEARARSFESDVSQFLDEIDGNKKPDLEEQLKELEEKFIKQSREEKIKRELARLRKLLGKGNEDENTGSKPLAQNEDQIEFLTRLEKLMKSRATDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0C5</accession>
    <name>A0ABM5K0C5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503640.1">
        <property type="nucleotide sequence ID" value="XM_050647683.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647683.1">
        <property type="protein sequence ID" value="XP_050503640.1"/>
        <property type="gene ID" value="LOC126882702"/>
    </dbReference>
    <dbReference type="GeneID" id="126882702"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="560" mass="64778" checksum="8CCA3B4C08EED0FF" modified="2025-10-08" version="1">MKDEETTVNPPSNFQNNLIQQGTVSMFHVNLQCISNKVDMINAFLADKKFYDVICFSEHWQTEENLKLINISGFSLANFFCRVEKKQGGVAIYVKENLMYSSLNLNEYNVEQTSEFCAIYIPSMRTNVLTVYRSGNGDCDLFLVNFENVIAFLLNKADKLIILGDFNINFKIKSDSSYDIQNLLMSFGLEITINDYTRITSQSSSCIDNIMTNFSENIYRMGVFEPCFSDHRAQFISIDSDLKVVDTNQSLQRSITSSGLQKLKYALASTKMDFFYDTNNDPDVLMFFLTETYNNLILKFFPLKKVRQTAKITPVQWFNDELRSYRSNLSLIKHIADVTKDPDIFKLYKQQKYEYNRQLQNAKKSAYSGFITNSNNKPRDCWKILNFERGNTSSSSVQPDLSPEEINQFFITIAENIITSLPTINNDILFSYRNYPSPSKSFCFRPVVEDEISQIIKSLNNSNCKDVHEINSKILKETYQIVLTPFTHLINLILSTGVFPEALNIMNTVHNILNTNFSNLPLEDKLKIKELGRPLPNLKLTQSRKQKFHPPFFKRHLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K306</accession>
    <name>A0ABM5K306_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504576.1">
        <property type="nucleotide sequence ID" value="XM_050648619.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648619.1">
        <property type="protein sequence ID" value="XP_050504576.1"/>
        <property type="gene ID" value="LOC126883280"/>
    </dbReference>
    <dbReference type="GeneID" id="126883280"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="456" mass="53622" checksum="90D0F55BBDBAD79A" modified="2025-10-08" version="1">MYHRGKEKETGNKETDVPNQKPKQNVNHKPKLPEKIFEVRKSILTELYEDNIHTRAIINFIIGFSVFNMVTLILKDYVYYGRLSSAFILIFNQFAKLPVTFLIWILLNLLIFACYYVYLLWGKLRRKVPNTWFWDRIWLVVFIGYIIIMFYATTILVIHLELQFATRLLILSESTRLLMKLYSFVRSNVPRVTNTRSSNDYVHIPTFGKYLYFLYAPTLIYRDEYPRTGHIRWSFVFYRLLEVFGIIVALAFLAENIANMIFMDTCKQPITVPQFLVLILQGSLISTVMSLLLWWLVLHSVQNAVGEMLTFGDRLFHSDWWNCIEMPEYYRKWNIVVGDWLYTYVHKDIIEYFNPRMKLIPKVATIMLSALMHEYIITGSTGFFCPIVTAMMLVSICVSNIKVTNKGFNRLLIIILYPLGPGTIGTFGFVEYYSRQNIPDTDTLSVFWSNNCVTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3P7</accession>
    <name>A0ABM5K3P7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504805.1">
        <property type="nucleotide sequence ID" value="XM_050648848.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648848.1">
        <property type="protein sequence ID" value="XP_050504805.1"/>
        <property type="gene ID" value="LOC114326863"/>
    </dbReference>
    <dbReference type="GeneID" id="114326863"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="322" mass="36650" checksum="EA4E136AD5C48F51" modified="2025-10-08" version="1">MAEQNANDNNWFGSWINAAKNKGSEVLEFVKKDLEEFGSAVKNEATNVVSSTGAVLEKTLSLDSPSSTASNMKRSFSSFLGQMNNVLNPSPDDSDAEMLIVENSETVTLNKFQKALYELQKDPVTYLEDPDESLRKQYNCWLEIIDDQLNDDRIAKHVNSSEILKQHYAKLVPDIVEHQVFWKRYLFKKALLEDDLARQEALEKREQKEKQATEENLKWDQEDFAADIELTEEQQIELLEQYENEKKVSQKSSQQPIGETVVFKQESPKRKGKGSKRKPTTEAQNTEAATPKENDLSASITSTPSSNSSLDLDWEKISDTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4Y6</accession>
    <name>A0ABM5K4Y6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505253.1">
        <property type="nucleotide sequence ID" value="XM_050649296.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649296.1">
        <property type="protein sequence ID" value="XP_050505253.1"/>
        <property type="gene ID" value="LOC126883640"/>
    </dbReference>
    <dbReference type="GeneID" id="126883640"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="92" mass="10219" checksum="47E71F0F33D8F5B0" modified="2025-10-08" version="1">VGVLTRFVFVLFSGRHTRVCYCYFVIVIGVNETAEWHGDQKIFCVTAISAKSEEKGSTAEITEGGVDHSFVTIKMESGRGHGLEYNILIYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K591</accession>
    <name>A0ABM5K591_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503484.1">
        <property type="nucleotide sequence ID" value="XM_050647527.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505328.1">
        <property type="nucleotide sequence ID" value="XM_050649371.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505330.1">
        <property type="nucleotide sequence ID" value="XM_050649373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505357.1">
        <property type="nucleotide sequence ID" value="XM_050649400.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647527.1">
        <property type="protein sequence ID" value="XP_050503484.1"/>
        <property type="gene ID" value="LOC126882558"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649371.1">
        <property type="protein sequence ID" value="XP_050505328.1"/>
        <property type="gene ID" value="LOC126883710"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649373.1">
        <property type="protein sequence ID" value="XP_050505330.1"/>
        <property type="gene ID" value="LOC126883712"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649400.1">
        <property type="protein sequence ID" value="XP_050505357.1"/>
        <property type="gene ID" value="LOC126883737"/>
    </dbReference>
    <dbReference type="GeneID" id="126882558"/>
    <dbReference type="GeneID" id="126883710"/>
    <dbReference type="GeneID" id="126883712"/>
    <dbReference type="GeneID" id="126883737"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="666" mass="77489" checksum="F20CBF78DC33B5E7" modified="2025-10-08" version="1">MNKTNSKKPKGKNNDDQRQKDNDDALISKIENREEQSQDGTIDEDELRKFERELLQRHDQQPKLNRSGAIKHSTLVGEEINTREEEEKEEEEKEEEDPSVKILEAKAFTESHDEKTEEERGGTWEDIEESVLTAFLFDEEDRREMQQMKKRKGDSLEINEKFKKEKLEESKKYPEETDREKVQRKMKQILDILNTEGPIEDERIRMKKLIGEINSMQNRKISPNQTTQGEEKNIRCEQCKIKIEQERQRKETEKIIGIVNKGGDIDTFSQIHEKKWEDKVFEKTKWEHGGLQETIEKKECIIITKNEIKDGGVEGVIRTLREEVAEIIEECKVGDIEYIENVKKSSMANQRRQWYTYVTKVGEQGMYEMAVKAINIIKKREKPPETVRVIVNNEINKEDVRKALEFVGRKENIVWEIVIRGKEMDKGERHEQEEALLIKTGGKSYTDVLKEMNQKIDIGKIGLKVNRLKKTEGGDILVKLKGKGAAEKLKKEMDSKITGMSMAVRKKENYFSITAIDPGFTEEQLISAITTYTGIPEDEIDVKTLRINRHGEQVATIAVRPSKAEELRRYRTIVIGWVICPIMERHTPVRCYKCLHYGHSTYECTGESRVACCYNCFKNGHTAVQCSSTAYCLTCKEEGHRMDRMTCPAYRAWVYGRGGEREHIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5F0</accession>
    <name>A0ABM5K5F0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505413.1">
        <property type="nucleotide sequence ID" value="XM_050649456.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649456.1">
        <property type="protein sequence ID" value="XP_050505413.1"/>
        <property type="gene ID" value="LOC126883787"/>
    </dbReference>
    <dbReference type="GeneID" id="126883787"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF13">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="103"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="242" mass="28414" checksum="674FE93956D88C57" modified="2025-10-08" version="1">MNGKESDPDPFEDSDSDWEKDNLGTESYGSDSSRSHGDKYIHPASLRRNIRQDIAEILNITKGDDANMTQKKMRTICFYCPGTYFLLYDFIDFFEKDGPSFLQREKYHEIIDRIFKNMSRLERDAIIFQYTNWEQVHDGYLNQKMIGDVVGDYFFVCPTNDFAELAAERGMKVYYYYFTHRTSTSLWGEWMGVMHGDEIEYVFGHPLNLSLQFNSRERELSLKIMQVFTRFAGTGAICQQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K841</accession>
    <name>A0ABM5K841_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506361.1">
        <property type="nucleotide sequence ID" value="XM_050650404.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650404.1">
        <property type="protein sequence ID" value="XP_050506361.1"/>
        <property type="gene ID" value="LOC114343615"/>
    </dbReference>
    <dbReference type="GeneID" id="114343615"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00122">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052283">
        <property type="entry name" value="GenomicStab_NeuMorph_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15739:SF5">
        <property type="entry name" value="LD23158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15739">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBD" evidence="2">
        <location>
            <begin position="337"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146875" checksum="67AD2F10155D9668" modified="2025-10-08" version="1">MEPNKKLSEKSKTTNSEAEPETPVSKEKTAPNLNGDDTEIDKETTIDEPVKGEKEATSVEEETVVPEKQGEEKEGHKEADQEPKNAEQEPKNAEQEPKNTEREPEESEKEILENESEHEEETKENTVKEKVSQKPESMDTEEKENVAEPVNKVADDKTITSTENNKNITEDAKETANNAKEGVKNAKNVPERIENPKEKVPKGRKRKISEIVNTENENRTETTKVLPTQKESKSDPLSHLDPLVVVKEEPVDVDLYPTSVTETLGKGKRARIPNKRYSDILMSPTSIKKSVSNTTENGSLESGNDTDTSIKEEPWQSPSYSGNSSPVVKRIKSSHTDLSDPKYLKPFKYGWKRELVWRGTYDQSKGRQADIYYYTPLGKKVRSTREVAELLNNKELTIENFSFFKEPIGLSDTSKEIIRDAKVKQAEPLSKLVFNKSIKSTPIQGTKSPKLLTKFSSLPTKKLTSPKIASPKITSPKLATQKVATPKLVSPKNTSPKMTSPKITSPKLQRTKVVSPKLGSPRIALSRMKSATSPKLVANAVTENASNKTSKIMVKKEMKKNLEKPAKRKEIEEPSPIGTPGKRSRRESAEGDGNQSEESSGVGLDKPCQPCSIRCKPGTIPTLQCRVCLCLYHHECVGIAPHFSLAYVCKNCHQDQTSDQSAILMSGTISSPTILSPLPPLTPINTLKSSGGQPITLPPPKLQRIPKPTDSENSSHLPSPPRLKTEQKSLVGSMTTWLPHNAKLIENIRQVNETPSGQGIHRPQYVEILGGRKFLVIPKHNFMSVSPTVATSAVTSRPNVDPINIDSASLGSDPVSEIKTEPESPSKPENSQTPEAMEVEDIFEENISADSATGDGETGVQPDIKPELATPKAPTPPPAIVKTKKRSIKLSSITSSEEKEEKKFMENYLQNISYGYNTLLYIFQYLKVQDLLRAGCVCTMWRDIASHPMLWRTVRMKNSQVHSFEGLAHSLKKHGTRHLDLRKMLLPTGGDEIWPAFSEAIEKVETLRRIELCRCPASVVEKLATSNPQLEIINAVTIKCETMNLEPLKALTEIKELRLKATGGLTLTSNIDSLKDMTQLRHLSLTSIRHLNEMNLNVVADLVNLESLDLGECTNFPENFGKDILIKLTKLEKLRLEKGQKDCHTFEILEAVRRMEHLDQLELVNFDIKAGFDKALGVCQNIKKLLIIPTYISQSATTNHMVLGGVLRLQNTLSHFVWGVTLELLRVTELFVDQCEDPKEKKEKKQVGNGDCIPVLKPVPLLLDKDSEIAPALEPPQVEILALPSLQKLLMQNLPTTRVKILKIPFHATWRQSITDSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDD0</accession>
    <name>A0ABM5KDD0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508197.1">
        <property type="nucleotide sequence ID" value="XM_050652240.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652240.1">
        <property type="protein sequence ID" value="XP_050508197.1"/>
        <property type="gene ID" value="LOC114343029"/>
    </dbReference>
    <dbReference type="GeneID" id="114343029"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="227" mass="25989" checksum="F09A908B4F0E7B4E" modified="2025-10-08" version="1">MSSKLEQVLEINPPNELVFKGRYDEPVTSTLTLTNPSDKRVMYKIKTTAPKMYCVRPPSGMINAKDTRHITISFQPSEDAIETTTHKFMVQSAYAPPGDVNMEQIWKNIIPAHLMDTKLKCVFNLKEEKNEERQDFTPKLVSTPISASSEINDVAQELLQDIKKEQESFLKLENQTLRDQIRQLQMEMRASNSTTDYNHNNYSYKVVYFVVSLVVAITGAVFGKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEZ5</accession>
    <name>A0ABM5KEZ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508771.1">
        <property type="nucleotide sequence ID" value="XM_050652814.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652814.1">
        <property type="protein sequence ID" value="XP_050508771.1"/>
        <property type="gene ID" value="LOC126885976"/>
    </dbReference>
    <dbReference type="GeneID" id="126885976"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="73"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="375" mass="43002" checksum="B1D1D01F851EE6B4" modified="2025-10-08" version="1">MPSSPEETTFPQRLQSSNNLGEQNSKDQIKKNGYFEQDLVWRNVIIYIVLHYLLIFAIWRLLTGQMKLGTFIFHCIYATASVLGITAGNHRLWAHRTYKAKLPLRIFLMLMQTTTIQNNIYVWARDHRLHHKYTDTAADPHNSNRGFFFSHVGWLLMKKNPEVKNKGKNIDMSDVAADPVVQFQIKYYGRLALLMAYILPAICTMYLFGETFANSLLVSNIRHLLGLNFTWSVNSAAHLWGWRPYDSSINPVENPSVALITLGEGWHNYHHTFPWDYKAAELGNYALNGTTAFLDLMAYLGQAYDLKTVSPEMVRKRVARTGDGSYKHGKVPLQNGNAKDHQDTTTKDEGFVWGWDDKDMKVEDIKDATITFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF38</accession>
    <name>A0ABM5KF38_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar pre-ribosomal-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508817.1">
        <property type="nucleotide sequence ID" value="XM_050652860.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652860.1">
        <property type="protein sequence ID" value="XP_050508817.1"/>
        <property type="gene ID" value="LOC126886020"/>
    </dbReference>
    <dbReference type="GeneID" id="126886020"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1798" mass="206649" checksum="EDCEE433A0CEA709" modified="2025-10-08" version="1">MGKKKNQNPTEESDKPAKKTRVFSAKEFRKELNTNTLASLQQFSKAIKESEEYDYIFEYLECGGNCLELLHSLEVDSAIAPLHVFDLITNILLRINTLYPQYHSSAYESCRYILNNYVTVLNKMINFSSTTPERKSCLKLLTAMVAFSPVLAKDILIHINFHSSNVELLTKHTGEKDSTRDNFIKFLTAYLVDGHYPALSVLLEKKGFFTSIVSGLKFDSADTLCLVVTAMKTFILENPSVSKTAKMKTFNTVVVRDIVNLYNWKGPGGFRAEKKKNSAITVNEVEKSKVNESVHEFLLILCTNHKYGIIFKDPLVGLGKKNQNALMYTVLESLDRPWEHSYASELVTKICGACPDLAKTLWTNLKSYLEPRLSQKWVNAMKFAVNLVKELQPNCLEYCIKDLSDIQLFQVVQCLVLPLPILKTLLPENNTFESAAVKQYVLSLLLEMLRALQEYSTASKRYLTLEKHNNFQLFLNKHLAKNFPNAVTVLKDWEILNDDSPFSTIQLLEIIFDIFSHYKSLSSELLESLGSSDTELSDLLAKSDQLSEAEESLEKLQVKIISVFVDLNQSTFTVSSKMFRCTVPLLLRIYYNSSDAATQSVLFKLLRNTSIFEGCFDEINIWINGVLNLKHFDKSVAENVVDILEITNENLNKFVEELSKMQSENSREKHYEDIFQNLMLKEEVSSDIHTNSIKHRYLSPTVLGLLTFLDKNEPSKAFKTYVAFVMTNLLHQQTQIGPIVSFINKCDALSSSFKEYATNWLDCKEITCLNKAKGRIEVIKEFSEQFLTGDIETFIQHIDSNMYSDLKLNVLDAGIFYTSNLLNNEILTLEFAERFEKFCKSIIKQNLSDPQVLKRILSHPTLANSVNFLNMEGEQSGSYITKVLVNIITYLIDEKCEVEEYLKFYREQLSNSILKVLKKPGKYENMSLELKNLLPRFGLGCNDCFVILRTISKGFATYTQHSLVVGILCYTLNRFAELCTLESIGETTEIILNLTVYFTNLANSQQNVAPLSSVFLEVFKKFHHLLNNVDNGLFKALLQLEDVHKDNTKLLSFLLEKQSSNIEHVKEQLQSVCDKKALLLPLLAVLSKQAANKKFFKKVYDLILPSLNKTLQKPQKVGQHFHEHYQGLVALIKVAMPVENCQQLWEKVQKFDSTEIFHVHLLDAIVTKVLEDSVADKLVNNIIVTFVHLQIYLFKKNVKSEVEIDKAVEVTKVFVQVLKKVKEKCTDVDFKSTANNETVKLYFKFCLKYGVSKQPVFLQALQLLIQLLSKHLEVEDGRLILDMLTSHSEFLETVLGEYCDTKTEILSLYLELCRKWPEFMERHYVPLLLASYRGLVNKCDRIVLLLLKMYASKPDQTHFYDFKPFLWDKAAATHYSVRQQIENALWRQPKTSDVLDILQEHLVHSTITNYPLKCPLRSEDSGMLDVDDTKSYDLTFLLPLFSQLLAPEQHIQTYKFTRSGALSLTIIGLSSADTEIRKAACHVLARLHYHVDARQSGKDNLLWLRYIEAVCKGVALLPDLKLNNFAAIYLARMALILTQPNHVMYLPLSQHLTAKSSLDFSTIPELYTFLHSSDVNYKEHRSFTLELIRDGLRTEKDFADFMRSMAFKLISELYSSVVADYDTRVLILDAIKSICGISLGVKVVCENYSFLTQFSNDLNKILTSTKEKINNLLFRKNLDIVLRILRVAKDRHAHFMIYNALENFFSSTNNAVYWIEGSEEVFFEIVDILFSKYPSMFTKRFYNALEKVVDDPVCNYVRIYNCDFFDIEELNVEDKHYFIRKFFVSFRKSKEVYENIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF48</accession>
    <name>A0ABM5KF48_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508827.1">
        <property type="nucleotide sequence ID" value="XM_050652870.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652870.1">
        <property type="protein sequence ID" value="XP_050508827.1"/>
        <property type="gene ID" value="LOC126886033"/>
    </dbReference>
    <dbReference type="GeneID" id="126886033"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="148" mass="17335" checksum="66D820FD3F0DD604" modified="2025-10-08" version="1">MKDLSKEDFEKSINNINSTYCELLDNFKEQSILWFDLWKNTEIDAKALEKLNLIEVLEHEHACFLPSVAKAIQIALCLPPTTCTIERSFSTLKRVKTWIRNTMSNNRLSGLCLLSVHRRKIKGNKENFMQKVIDLFAMDTRRIQLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFC5</accession>
    <name>A0ABM5KFC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508889.1">
        <property type="nucleotide sequence ID" value="XM_050652932.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652932.1">
        <property type="protein sequence ID" value="XP_050508889.1"/>
        <property type="gene ID" value="LOC126886089"/>
    </dbReference>
    <dbReference type="GeneID" id="126886089"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37641" checksum="877A8ACF3083800A" modified="2025-10-08" version="1">MTSLRARRRSSNPVLTREYRRLRGVWDEEYRNLAINEWRNCLFTDESRFHINNSDYLFFVYFCVGTVIYGAVPILELKACNERRISEEYRRHDPCGIPLRTWSPLDATDPIEFFVLMAIHTPSWLMIVAVIMAITLTLVVLGFLIHINAQLQYLQSNILHMFDEAKDHLKIRESRVRMCTEYHIAIIRYTKEVFGHFDLLLIVHVSLTSLIMGVLCFQMVFEENASDKLRYFLHLAGWVAVLFLTCYYGQLILTQSGLIGNAVYNSKWYNCPPALQKSVLLMILRSQRPLQLTAASISTLSLQTFLSIIKAAYSFFTLLLTMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFZ5</accession>
    <name>A0ABM5KFZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509119.1">
        <property type="nucleotide sequence ID" value="XM_050653162.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653162.1">
        <property type="protein sequence ID" value="XP_050509119.1"/>
        <property type="gene ID" value="LOC114325298"/>
    </dbReference>
    <dbReference type="GeneID" id="114325298"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="217" mass="24803" checksum="815830F4F39F6EA9" modified="2025-10-08" version="1">MTRVRSRSPPRSKALSPPRYADSKESLLLQHPEESSDDHSSDQEDGKDGFTIQNRRIRKKKKKSKGKDSTQNVETTENVTEATQEVEDSQNIEATQEVEDMDEDVPGAEGGGTTKRQRVEEDAASEDELTRANEEINRLRTLMKEFAANVDANNKKYEEVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKPEKKNPEKTDKKPPVYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIC5</accession>
    <name>A0ABM5KIC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509858.1">
        <property type="nucleotide sequence ID" value="XM_050653901.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653901.1">
        <property type="protein sequence ID" value="XP_050509858.1"/>
        <property type="gene ID" value="LOC126886829"/>
    </dbReference>
    <dbReference type="GeneID" id="126886829"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="575" mass="66049" checksum="0590127B6C12FADE" modified="2025-10-08" version="1">MPRISSEGKITRKEKLYNMYLNREMVDTEIILKDGQISAHSLVLAAASPMLYGMLEPQIADLKTVALRQYSKLIMRYILEYLYKGDFLCPKDEETEFKAAAEFLQLEGLHSNRQKQTVKQEPSTSQKVETVTLQEPIVIADDSDSSNIEPNQKDTHPRKKIKLNSTASRCSARPRRRFVISDSSSSDEELEDSLDFLIREAKQRSATRDKNERDNSFKEQSKKLMNIIRSQKNKMNTIPESTADSSLVLLESPPSIIEIYEESVPVQQEDLGSSETLMIHTDATQNSPNVEPSQRPCRNEQPLQQEDLGSNETHMIQTDATENSPNVEPPQRPCRNEEPVQQEDLGSSETLMIHTDATQNSPNVEPSQRPCRNEEPVQQEDLGSSETLMIHTDATQNSPNVEPSQRPCRNEQPLQQEDLGSNETHMIQTDATENSPNVEPPQRPCRNEEPVQQEDLGSSETLMIHTDATQNSPNVEPSQRPCRNEQPEAETIPPNIEEETRPPKRGFWRTRHNSKKFGRNFCAICYKSRRGIKRHIKLNHRHLTRKPYFRCSRCLRNFYYESVYEYHKENGCNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJQ3</accession>
    <name>A0ABM5KJQ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050510436.1">
        <property type="nucleotide sequence ID" value="XM_050654479.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654479.1">
        <property type="protein sequence ID" value="XP_050510436.1"/>
        <property type="gene ID" value="LOC126887121"/>
    </dbReference>
    <dbReference type="GeneID" id="126887121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045469994" evidence="6">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="8">
        <location>
            <begin position="251"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="440" mass="50154" checksum="9727BB49A6B24196" modified="2025-10-08" version="1">MLIFIFLYSVVYFLGCVHSKFTTTKIGPQPIWNATFTDKLRQDLLLNYDKFSRPAQHYNVTTVKFGMGIRHLEFNELKSSLTVYAWLRMTWNDEKLKWDPEAYGNLSVLHLAEHELWQPDIYLYNSATSTAVNQFGNTHFLAYSDGKVLWVPPAQLVVLCGLNLKYWPFDTQECSLKFGSWTYSGDQIDLLHYNDNAEVGLEFIISNSEWELTNAVQTRHVKYYSCCAEAYPDITVNLTLNRISTSYKAIIVTPAFVVIMLTMLSFTLPPQAGEKIIINACTAIVVSLFTLYFTQKLPIMGTETPLIVMFYTSCLYIVGFSTIGSVVVISLSRTKHSTSIPWIIKQPLIGRIGKILGLDNYIQQATTSSHRVTAEEMRDHPVSEFDESTNSEDNHIIRSHISSAKPSIQKDWILLAAAIDRISFIFYFLLFVILSIVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KND1</accession>
    <name>A0ABM5KND1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511702.1">
        <property type="nucleotide sequence ID" value="XM_050655745.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655745.1">
        <property type="protein sequence ID" value="XP_050511702.1"/>
        <property type="gene ID" value="LOC126887850"/>
    </dbReference>
    <dbReference type="GeneID" id="126887850"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045811">
        <property type="entry name" value="MTP_lip-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039988">
        <property type="entry name" value="MTTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024:SF0">
        <property type="entry name" value="MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024">
        <property type="entry name" value="MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19444">
        <property type="entry name" value="MTP_lip_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vitellogenin" evidence="6">
        <location>
            <begin position="41"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="897" mass="100623" checksum="BE82BCB2C2FABC6A" modified="2025-10-08" version="1">MFGFTNSYSILYLLFTISLGLCYGFVLLSSAAGDFNEINVFAKGVSFKYKLQSTVLLNEKGLRGKSVGFFINGELTVDSVWENGDQKLLRMELISPKLHIRSRKAPAPDGFIPHSSKLDTIENKPFLVDWNKGKISKIFLSNSEPVSIKNVKKGIASLFQFQLLDGDLTEIDSSGTCTTSYSSSSPNKFAKIKTNCKSDDLPYTHNKHNMLGVEVESSRMTEYELGSNAFEIKSITSKDSHIAYLAAREEMGNHIESEQTITLTDTSTSKSLEGINIEEVVEKIGKTSGISFHQETLLTEKEPASEEILSFSKTIENLRNQLKNENIGTLKQAKAHIEAVNAGRLAKKEDILKALSSKKNKNILSQLYDILGYVQTQDSHEAVMKNLHFDNENQIDFSERYLWALSFSSQPNPDIIKDILKKYTKTVNIPEKVKETMILTIASMTHKFTKASTNDNRFSLVRDVEETILNELDYAKDEDKFKYFRALKNLKSQTTIPTLLKYIKSGTQKEGVLAWNAIKSFDSSFWNKEVLKSADKSFFQLDRKYDSSSRTIAGDILLESQPSDEVLKDLLNFLTTNDTAYEVKQYMYQRIRMISESDKSFKSRVEQIIKSNKYLNNYSGLSPRGLSTALSRKFLTHPSVNGSLVTLQEMKSGIAKRGTIDIVLQKGDISDELFSLGIFSGGLSSFISSDSEGEETEEESATAGIELTVLDTQIRPFVFFSGQGELMGHVWSGTASDKTPAFQVQALLHDHLEYIRLGSGYIAAINFKGSTSFDLSGKIEISLWNRNAESLVQKSAGVIILGTSTIDTVFVKSKAEFTASIEYRLDLQTDIDFSSGAQLCMRLTQPDTLFRHNIHKVERIPGSKHKMRISRYQKYIIPGTTYALNKKNTEMCNAIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP33</accession>
    <name>A0ABM5KP33_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511957.1">
        <property type="nucleotide sequence ID" value="XM_050656000.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656000.1">
        <property type="protein sequence ID" value="XP_050511957.1"/>
        <property type="gene ID" value="LOC126888008"/>
    </dbReference>
    <dbReference type="GeneID" id="126888008"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="206" mass="23696" checksum="97407AB6E0BB9528" modified="2025-10-08" version="1">MEQQIPLNIQEIIQATVDRAIATLLESGLLKEKKGRKHHSRSRSPHKGKKDKKKHKKRSSSSSSCSSASGEDEGKKKKEKKEKRCAERQSSRSHSRGRHSRSRSRSKHHHKMHHHSKSPATHHHFHYSPCWLAENSSEGPCHKSHDGKRKKHSRRLRCMKFYYKQGPATSDENDEQEKDCELTKNFENLEVGDNNPSAPLVTISTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPL5</accession>
    <name>A0ABM5KPL5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512128.1">
        <property type="nucleotide sequence ID" value="XM_050656171.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656171.1">
        <property type="protein sequence ID" value="XP_050512128.1"/>
        <property type="gene ID" value="LOC126888179"/>
    </dbReference>
    <dbReference type="GeneID" id="126888179"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039147">
        <property type="entry name" value="ASB17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20966:SF2">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SOCS box" evidence="3">
        <location>
            <begin position="294"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="338" mass="39663" checksum="25CB2554D50B9FBA" modified="2025-10-08" version="1">MESFLRCYLDCFNELPRNSLHDRRKRQHVVDYISTLIEGCSRVEKNSDESAIEAVKTILKYHQENKDDNGKVCMMGRYHNILYVAVKLCFDWQIKDAATVTMLLDEIYKCEKTFERILIGAIFGNKAPHYIAGWKSDFDSEEENIRAVVYFLDKANRAQLNISLDFSSKDESFRFIDLPIESCGKASPLKICLQLGLPDKLLIFLRFGAKVYTQNEDVTLFEHILNRLLEFNHVYPYNLVACLQLLLRTVTRIKIDIPVEMSQESYQLLLEKMYERYFDLIQDGLIPPERCGISPPQLKHICRCVIRDRLWENYQLPDGIRSLPVPEKLWRYLDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRS4</accession>
    <name>A0ABM5KRS4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512888.1">
        <property type="nucleotide sequence ID" value="XM_050656931.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656931.1">
        <property type="protein sequence ID" value="XP_050512888.1"/>
        <property type="gene ID" value="LOC114334013"/>
    </dbReference>
    <dbReference type="GeneID" id="114334013"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="324" mass="36170" checksum="862979D6E0AC948C" modified="2025-10-08" version="1">MTISTKILGLVAKNSSLDNNSINEKPVNNTCETTEEEKLLNKLEETEPELATCQEEECVICINAKATMQTAPCGHLVVCRKCFVKTIQIAVSQRLLPLRCVICRAKILRLKTGPILPTSASGYSITSRGSSVPQSDSLYSVSSGESSISFASSSSNNSNKESAPCCSGRCLGAYPRQPHTGAIKRSQEHAMKIKIQDYCRPEKNHVNRLPPIKEMPGQSPLHTAPPASTRIRCAQKIVTQLELPLMRRGHKYERIPQEDDAEVPVSVKPVEKTKRWWSDRTKSEEKIDNKKNELVEKHMELKERLMKAEQLTEATSTNIKDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRX3</accession>
    <name>A0ABM5KRX3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512934.1">
        <property type="nucleotide sequence ID" value="XM_050656977.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656977.1">
        <property type="protein sequence ID" value="XP_050512934.1"/>
        <property type="gene ID" value="LOC126888621"/>
    </dbReference>
    <dbReference type="GeneID" id="126888621"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="209" mass="24878" checksum="35158C7BEA14F9FB" modified="2025-10-08" version="1">MEKTMDTEKETTNNLLKQVLNEIRQTREENKVFRDEILKLKKENNKVKTELEETKKKLNILEIRVERCEKEMKQNNLVITGLKIDANDEAELKEKMTNFIKQHLEENTKIEKAVKLGDRTCLLKMESIEEKNKVMKKKSKLRHIKGEKIFKSQDMTVLERNIQKEIGAKCKELRDMGRNVKRDYNGLTVDGNEKWRWRKDGKVETFPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSN8</accession>
    <name>A0ABM5KSN8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513204.1">
        <property type="nucleotide sequence ID" value="XM_050657247.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657247.1">
        <property type="protein sequence ID" value="XP_050513204.1"/>
        <property type="gene ID" value="LOC126888830"/>
    </dbReference>
    <dbReference type="GeneID" id="126888830"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="668" mass="77973" checksum="00D60FAA28E7D929" modified="2025-10-08" version="1">MELSEDSIKRKQNVLISDQDGVSLEKHDNVQIKSELEECMFESNYTEDSLPDSYCSDDIKIEEHELQCEISSSFSIIIKQEVKTEIKKELDDDNLGVNHGCESRFKITNTKELDSDKDIKLQIGASTEIYHDHGEHCRNTKRSKLLSNIDKQKINSTNVNSNAQSWFAANKLRLNDTKTQNLFISSNPFDAHVEKNTVKLLGMTIDNTLTWYNHIDHLKGLRQKEVKTKSERTLVTHTGGRRYKCEICSKQFNRGGLLKSHLRTHTEEERYKCEICSKQFSKACNLKRHLRLHTEEKPYTCEICYKQFSQNRYLKNHLRIHIGEKRYKCQICSKQFNEANYLKKHLRIHTGEKPYKCEICSKQLTAASSLKKHLRIHTGEKPYKCDFCSKQFTEAGYFKKHLRIHTGEKPYKCEICLMQFSQAGSLIKHLRVHTGVKAYKCEICFKQFSDKSNLKAHLRIHTGQKPYTCEFCSKQFREAGQLKRHLIRHTGEKRYTGEKLYMCEICSKQFSKAGQLKTHLRVHTGEKPYKCEMCSKQFRQNGQLKKHLRMHTGTKPYKCEICLAQYTSASGLKQHLKVHTGVKPYKCEICCKQFTEASGLKKHLRVHTGEKHYKCEICAKQFSEAGHLNRHLRIHTGEKPYKCEICSKQFSRKDYLKRHLGIHVGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUP2</accession>
    <name>A0ABM5KUP2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513908.1">
        <property type="nucleotide sequence ID" value="XM_050657951.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657951.1">
        <property type="protein sequence ID" value="XP_050513908.1"/>
        <property type="gene ID" value="LOC114336397"/>
    </dbReference>
    <dbReference type="GeneID" id="114336397"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01226">
        <property type="entry name" value="PH_RalBD_exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="700" mass="80393" checksum="B3B0E857F7BA5D85" modified="2025-10-08" version="1">MEFSKEPNFQLLSARDFTPEKYVKNLSQSYVGGSELQTLRRKLQSLSEETSNNLKKNVYENYVQFIETAKEISHLESEMYQLSHLLSEQKSLLSALSTTSILEDTQHLNIERENKSNDKDIEEENKQKLAAILEKVEGCKELLEVPGRKFLYEGDLLEIDPTENTSLKTVHVYLFTDGFMITNRNSNSRGLMKYIYEIMYDLSSLAVVNVRDLGNVKHAFKLLIFPDTTVFQCSSNSNKKEWLDKFDQAKKTRLAQEQHKRESISEKSPSRSASIESPSYNPFDEVEDDVGTVQPEWFLDIPEELDVCVAQRHFEEALSLLQKAKEYISQMTAGNEKHDHVFLDIQRKVEQRQNSLTEVLMKELEVNPDKSLQGGLRAARRAVRLLNQLGRENQSCNLFLKLCSSMLRTQCKRVKREGSTTTYIRNLASVVFTNMCHMSDEFLRAFPDSPTCASAYVVWASNELLLFTGHFIKQVFMPQTSLSTVTECIVLVRTQCERLYSYGLDLCYQLDGALRSSLVKALKDARDKLIDSIKLRALEDKWIPINLHSKSALGRFLHEHSQMGLNLESYVSGDTWIQLTASTLSFTKMFFQLLNDCMKLKTTELVYTIDETLYNVFDAQLKHNENALRNELNQDQRSFLTKNAEFLLVNVVEVSQKIYSQNVGYECATLKKLQGEYVALKKGVSPTTRSTKTKYSSEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUR1</accession>
    <name>A0ABM5KUR1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 6k1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513927.1">
        <property type="nucleotide sequence ID" value="XM_050657970.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657970.1">
        <property type="protein sequence ID" value="XP_050513927.1"/>
        <property type="gene ID" value="LOC126889577"/>
    </dbReference>
    <dbReference type="GeneID" id="126889577"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF93">
        <property type="entry name" value="CYTOCHROME P450 310A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11965" checksum="5B2C03C215E8581F" modified="2025-10-08" version="1">MFVVLSSCGLSSLSTETMRKYPALPLMDRTPIDDYTFEGTDLTIPRNMSVLIPLFALHRDERLYSKAETYDPERFLDKNINSDGLSFIPFGDGPKNCIAKRLAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWF4</accession>
    <name>A0ABM5KWF4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prominin-1-A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514515.1">
        <property type="nucleotide sequence ID" value="XM_050658558.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658558.1">
        <property type="protein sequence ID" value="XP_050514515.1"/>
        <property type="gene ID" value="LOC114337883"/>
    </dbReference>
    <dbReference type="GeneID" id="114337883"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="893"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113356" checksum="876684F21B17D35B" modified="2025-10-08" version="1">MTKFYSHILIISLYILVTIGSINGNNVMLNDESGLTSNIFIGNTNCNESSHCTPSNFSSFNSQQERNLSISTPLKLAESTVTKIKNPQEADDGKIKHKNITTSSTRNSGMPFLEIPKGDDMRIQELKLDEEYLIFGAFSTLMGFLQPTGFPSDLLRQILNNRMPPYLVALQILKMDIIVVVWIIIWAVLSLCLPIAVAAQLCCANGSQRLDEDYSIGPFASAEKCTKRFLEYSLHILLFLLILAIAVILAANEQISRSTSKSPLSTNIVYEDINTFFRNTHMQISFVVTSSTDIAIEDIREDMEAVVDLLGQPYQQELALEVGIDLALIELEELKLSSYKVTSLVSALLEDCAAAKIAGVILQEKLNEISLQLTIARQQCDLKDRTLCYTLQHSGFEVSFSMDNLTSDPKIRHLDTLAREDNFNGSIEAARKSFASVPDQVALETTSYITEARAILNRKRTEVYKSTHALDVLMRSLSETLRLSQESVLTVVHKIVDFDFWRWIIVLGISSSMFVVWGLLLCGAPCGCGITSRTVPFLFAGIGISCFVVIFIWALGSFSVFIGGHSQSFVCNTMYDAPDYNVLGELFDSDGVIFKEGLFSEFSSKENDTLHVADAIKQCQRDYPVYQTFHLNNTINIDNIVNYKQWEDLTVLFSNLSHGECSLEILSPSLQLNLQGLSSASSLNLTYYRLQSSGPVTKRDLNSFADQLNTVARQLSDAGSARKFDNLAFSVRKTFQSEVKRLIEIRNTIMYKITTLEVLLPPLNQKINDSLENLKNIQFFLDTKGSEVANKVRTQFISRLISYLEDLYSYAKRKISKEIGKCRPLWEIFHSSRVYACKLIVDPLNAIAFSSFLVIIIFLTMAPIVLNLVQHYRQFDGDLSSFSPSNGLLDEESAWASPASGTPPEIQLVETSPPAFRERPTISTWTSPSPPRQSHSRARIPSPPRLPTISSQVQSPRKLSALTSRISKASRQITQMAITGSRSPRRGRRNHESLKLVEPICWKVGSTTPKSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY38</accession>
    <name>A0ABM5KY38_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515100.1">
        <property type="nucleotide sequence ID" value="XM_050659143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659143.1">
        <property type="protein sequence ID" value="XP_050515100.1"/>
        <property type="gene ID" value="LOC126890285"/>
    </dbReference>
    <dbReference type="GeneID" id="126890285"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="212" mass="25255" checksum="8A7F6A0A4759F926" modified="2025-10-08" version="1">MEEIKEYLTEIMAGFKENIEEMRELFSEYREMIGILKEENKTMKKEIQELNKRVMSLEKANETMEQLEKNSKRNNIVISGLKMEENKEKQKEVIKTFIKDTLKIESNITKVTKINESMCIAEIANYEKKTEIMRNKYKLKEISGSPVYIKHDLTKQERKVQKLLTEKANEERRLNKNVKIGYEKITINGKTFKWNNETNDIVEMKKKVFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY75</accession>
    <name>A0ABM5KY75_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050515146.1">
        <property type="nucleotide sequence ID" value="XM_050659189.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659189.1">
        <property type="protein sequence ID" value="XP_050515146.1"/>
        <property type="gene ID" value="LOC126890324"/>
    </dbReference>
    <dbReference type="GeneID" id="126890324"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF144">
        <property type="entry name" value="SPINDLE AND KINETOCHORE ASSOCIATED COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="4">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="298"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43075" checksum="C8B64703E07C391E" modified="2025-10-08" version="1">MGGPKIIKSGVVPHIFDCQPDRKRAFSQPVREAALKKVKRQLPEDAASTSKSVLENNDYKKQCDPSFTDLVQSGPELNQSALPQKLNNASTQTHIKIRSKVIQCKFQRSVTVGLSPLKIHNKDTGTSPIREMQIFEDTKSESASSVFEEYSEYSGSDDCWYNESDSLSCDEDTKEEEAKQFKSLSLKCTVMRLQYRPGLYMGLPEYAFYTFQLMEKYCKTQTMHLFLTLKKIRTGQTFMSLGDDFGISESNASRIFAKSVPLLSKYLRSYIFNPQVSSVKLNLPLTFRARYSKVFCIIDCLEIEIEKPSDSVKQSLTWSEYKKCNTLKYLIAGIPDEFSNFISYAFGGRTSDAVILEHSGFLNVLPPKVAVMADRGFKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZK8</accession>
    <name>A0ABM5KZK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515621.1">
        <property type="nucleotide sequence ID" value="XM_050659664.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519611.1">
        <property type="nucleotide sequence ID" value="XM_050663654.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659664.1">
        <property type="protein sequence ID" value="XP_050515621.1"/>
        <property type="gene ID" value="LOC126890593"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663654.1">
        <property type="protein sequence ID" value="XP_050519611.1"/>
        <property type="gene ID" value="LOC126893449"/>
    </dbReference>
    <dbReference type="GeneID" id="126890593"/>
    <dbReference type="GeneID" id="126893449"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="591" mass="67183" checksum="0488586443890EE6" modified="2025-10-08" version="1">MPRNYKRVTEKASWREEELQGALRAIQNGMSLRKAAIKFSIPKSTLHERLKNGTAPSGPSLGRKPVFSVEAENALAVQIKKLAKVFYGITPQEVRRCAFGFAQSNNIRVPFNQERKMAGKDWERAFISRHNITLRKPEATSINRITAFSRNEVTIFFNNLSRLMEKYAFSPNKIYNCDETGVTTVQRPPKIYAEKCQKRVGFVTSWERGKTTTAMCAVNATGTYIPPMFIFARQRMASHLQRNGPPGALYTCSKNGWITEDIFLTWLQHFQAFVKASKEDPVLLIMDNHSTHCTLQAYNFCRDNGIALLTIPPHSSHRLQPLDVSFYFPLKTAFNSECSKYLTSHPGEKITPSEIAELFNLAFSRVATPEKAIKGFKETGIFPYNPDVFTDEDFAPAETFQSTVSDALQEPTQAEKLLKTNETTPEKNSSVNETELKNVSFAEIIPLPSCSHENVVKRQNKANKQHSIVFTSTPLKEELEKKEEKKNKKTTIKSDKAKRNVFMTQEGSTLRQKSKRTKIALNYKICEEGESEIEDDDDVRVKNITEDICILCGEFGKNSELWLRCVYCGHWAHKACSNSPKDKKFICDFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L029</accession>
    <name>A0ABM5L029_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515794.1">
        <property type="nucleotide sequence ID" value="XM_050659837.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659837.1">
        <property type="protein sequence ID" value="XP_050515794.1"/>
        <property type="gene ID" value="LOC126890690"/>
    </dbReference>
    <dbReference type="GeneID" id="126890690"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF16">
        <property type="entry name" value="LP07342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047120318" description="DUF243 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="2">
        <location>
            <begin position="397"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="545" mass="59371" checksum="4470CC083AF81977" modified="2025-10-08" version="1">MRLLLLLGFILTVRAASRPLQTYFRSLPNHWFRGFGSTTAAPPTPFVEINGQPSSTPAPYLADNFQSINNRLSSDIRSDFGSTTSSPPTSFIELNQESVSTPSPLENEGLQASSTPFNLNSGLVYGQNLQNYGQNLQSYGQNLQSYGQNLLSYGQNLHGNLFNGFGSTTSAPPTSLVELNSESVSTPAPLESGGLQSGNIPFNLNNGLLSGQNINGNLLFNGFQSTTSAPPTSFVELNGQSVSTPAPFQNEAIQSSSIPFNVNNGLLSGFGSDVSNNLQSYGQNVNSNLLFDGFGSSTTSAPPANNEILSRFGSDISNIQQAGDNNAFYSTEGPVSSTSAPFDMRRLFLQDSSLFQSSPRLVPEISPIKIQGKTTGGSIYDTFGSNDEVIESQSEKPLITKNVYFFTAPEDEAVVKPRIYFEPTRKHVNVVYIKAPAAPSLGPIEITPPKQESPEKTVVYVLVKKPEEQKIIVKPGPTAKPANPDVFFINYKNEEEAQNALEELQSKEEVQQENQADELLNAHFDINPFKRKVSDKKVRKTRNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0E6</accession>
    <name>A0ABM5L0E6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515909.1">
        <property type="nucleotide sequence ID" value="XM_050659952.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659952.1">
        <property type="protein sequence ID" value="XP_050515909.1"/>
        <property type="gene ID" value="LOC126890768"/>
    </dbReference>
    <dbReference type="GeneID" id="126890768"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="359" mass="41514" checksum="4127C640955497EA" modified="2025-10-08" version="1">MVEISDRKLSYNIIGKENRKLVILVRLKRFIIIIATIFLVLLFIHSIIIPLIYKYSFKVQSAALFLNFVNVPSQADLANPQKYLPMSRNMYLETDDNVTLGVWQILKIEENQNCEKQTDDSIFEHAFLDSTDTMIYFHGNTGSRLLDHRIELYKILRKQFHVITFDYRGFADSTNETPSETKLVKDCEFIYKWVANKTKGSIFVWGHSLGTSLVTHTIFNLHSKIKEPAGVFLEAPITNMADEIVENPIAKIFSFLPWFDYVAIQPMKRNGLTLESDRYICEIDAPIIILHAQDDNVIPIKLGKKLYAAGKKCRRGTAGRIIFHEFQSTCGYKHKYIYRAPEISFIINDFVSLAKKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0S8</accession>
    <name>A0ABM5L0S8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516044.1">
        <property type="nucleotide sequence ID" value="XM_050660087.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660087.1">
        <property type="protein sequence ID" value="XP_050516044.1"/>
        <property type="gene ID" value="LOC126890920"/>
    </dbReference>
    <dbReference type="GeneID" id="126890920"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="474"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="565" mass="66695" checksum="87BCBD90DA969E21" modified="2025-10-08" version="1">MVNTRSTEFKKEMDKSGPPEWFLQMKADEEKRRQEENIEEEKRRQEEKEDKEKRRQEEKEDKEKRRETKEKLRQEEEERRRKAEVEMINSLTQIHENFQLEVSQLNNRIDTLDEKQNFLDNKIQQQQNSLVNLEQQQNDLKSNLERQIVELQTKINTQASLSHISVTNIDSEQTAPSSSIVYPGTVRTSKILKPPTFDGQTAWETYRFQFEAAARANGWNENEIAASLVVSLRGQAATVLQFLPQDAPNYTSLVQALETRYGQQHLKQVFQSQLKVRYQKYNESLQEFEADIKRLLHLAYPQAPRDFLEQIGIQAFIDGLHDIEMQQALRLQYHKTLDKALISAQEYEAAKNISRSLPQLKEIRFTENKQVTTTDNEQLVLSQILRLLQNIQQKPRNENRRCFNCGRMGHLKSNCRSRSQARKEEYKNEIRRSPSSTSRSLSQSLTRNDGRWSLRNRFPTTDHRKEENTLEFEVSHLKEQLAISKNKIERLREQVTILQEECKVIQNNAKTTQSNLENECQKLMKEKNVFNKQFQEYQNALNELQVQSQRQLAQKENVTEEFSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L255</accession>
    <name>A0ABM5L255_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516524.1">
        <property type="nucleotide sequence ID" value="XM_050660567.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660567.1">
        <property type="protein sequence ID" value="XP_050516524.1"/>
        <property type="gene ID" value="LOC126891392"/>
    </dbReference>
    <dbReference type="GeneID" id="126891392"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="299" mass="34292" checksum="60216FE72132E6F4" modified="2025-10-08" version="1">MEWNEENTQNLLEMYHERPVLWNSRLADYKDRKRRDALLEISVSFGVEKEEIEKKIRYLLSHFAREVKKEKDSEKSGNGTVETYKSKWFAYKLMEFLKDKNKPIVTQDSEGKRKRKEEDSQEVETDDGEESLQVLEQSIDGSENEVGTTAQSQSKSNSINIVKSRGRKSMATNLPIVNEAVNLMRSITTKRAEKDEFSLFGEQVAMKLRKIVSPFARFSVQNIINTVLFEAEMGKYDNPHFINHSHPSTPQAYPLQSFNVAHNSIPSPGHYPNTLSGRSSTSTSTINQDEDIHTLLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2B8</accession>
    <name>A0ABM5L2B8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516575.1">
        <property type="nucleotide sequence ID" value="XM_050660618.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660618.1">
        <property type="protein sequence ID" value="XP_050516575.1"/>
        <property type="gene ID" value="LOC126891441"/>
    </dbReference>
    <dbReference type="GeneID" id="126891441"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29834" checksum="B3C72E226ECBBE4E" modified="2025-10-08" version="1">MNIKLNINKNENSKPTVSSTDKQVTKRKHPTLSPIISTNNIESFEDFCSDDSVKDPDYEYSNGDANNRRSSSSSSGSNSCSCSSSSSSSSDSEADQACSKAVAPSKIENILRCFSSSSTNEDETPRDCVAEPVAGRFTNNNFSNPSDPVASRSTISADIASPCIEGNENVNSRKERKRKATPNNWLRAKAKILRNSGKSYLSNSKKEMTIVPAKSLKAPCSEKCKQNCVQKITETQRQQIFDNYWTMGDLQRQREFILRHLSVVEPRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2P3</accession>
    <name>A0ABM5L2P3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516714.1">
        <property type="nucleotide sequence ID" value="XM_050660757.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660757.1">
        <property type="protein sequence ID" value="XP_050516714.1"/>
        <property type="gene ID" value="LOC126891580"/>
    </dbReference>
    <dbReference type="GeneID" id="126891580"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43326" checksum="0240C4473EFCDF9C" modified="2025-10-08" version="1">MNISLSDVGHIAPIEILFGADVVGKLYTGRKYQLQCGLAAVETLLGWTPMGKVPTVASNFSTSMMSIALFVDSSSVAKLWELDISGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFKSYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFHASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKTFLKISVHSKDRDFLRFLWVNNEGKKFVFRHKRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGWESSGSIKTVVPVLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3E8</accession>
    <name>A0ABM5L3E8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516967.1">
        <property type="nucleotide sequence ID" value="XM_050661010.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661010.1">
        <property type="protein sequence ID" value="XP_050516967.1"/>
        <property type="gene ID" value="LOC126891731"/>
    </dbReference>
    <dbReference type="GeneID" id="126891731"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="349"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="430" mass="49324" checksum="49DAF6EBACAC6462" modified="2025-10-08" version="1">MSGFSSRWEKIKAALKKSEEKELNVANTSDPCGMVISKENDDGDVYMRLETNSSFTGMLLNESVEYTLDSYETPFVPELGYNDPCCSNNAEQNFVSEYLQSAQDEPIIIQELTSSSTVLQPTSWLSEYVESAEDEPKTIQELTSPSMSFQPEQHKNSNSTDGILFSEDQNSNLLVKPTNEDGSDDELIEDPHYIPESNTVLMTNENTTRKRRLERKRSRQQLEKLPDTRKARELRKKNRNSGKSYVTKKGKIIPERPFQTLPLCRAKCKTKITESQLKEIFSEYWSLGSYDKRAAYIASLFTIHDKKSHRPRTDDPDKEKYRLKTNKYFLRINGSHISVCQLPPEVTHVVLYSDTCGGQNKNSHISSMIMSILQRSDVNVQVVDHKFMVPGHTHMEVDVAHSMIEKKKKRSNIAIFLPHDWYQLVRSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5J5</accession>
    <name>A0ABM5L5J5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517712.1">
        <property type="nucleotide sequence ID" value="XM_050661755.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661755.1">
        <property type="protein sequence ID" value="XP_050517712.1"/>
        <property type="gene ID" value="LOC126892255"/>
    </dbReference>
    <dbReference type="GeneID" id="126892255"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="615" mass="71548" checksum="6E632275DF26BF7F" modified="2025-10-08" version="1">MERKEKIEDTVTNIKDENTIFVKPEFIKVEPAPGYLDPYIEDQWQGDSDISLNQIKTELLMEDMTFEQHQGDLAQFQYCNSDVDNIKLEHTAKGSQSSEYDSSTNEIKEDFNRESICDAFDDSGLNEYSLKIEIEDEKKLMPYGEKQTHKEGYLQDGNKVPVMEKLIEDSSYKGNDMSGQTESKTLRKNIKATTEKRPYKCEICFKKCTTASNLKVHLRVHTGEKPYRCETCFKQFFTTSDMKRHLRVHAGEKPYKCEICLKQFIQADKLKRHLRVHTGEKPYKCEICLKQFSQASHFKTHLRVHTGEKPYKCEICFKRFSVEGSLNIHFRTHTGEKPHQCEICLKLFSDASSLKKHLKVHTGEKSYMCEICLKQFIRISDLKKHLRSHTGEKPYKCEICFKQFSESGSLKTHLRVHTGEKPYKCEICLKQFSQASHFKTHLRVHTGEKPYKCEICFKRFSVKGNLNLHLRTHTGEKPHQCEICFKLFSDASGLKTHLKVHTGEKSYMCEICFKLFSDASGLKTHLKVHTGEKSYMCEICLKQFSHASPFKTHLRVHTGEKPYKCEICFTQFSVEGSLKRHLRTHTGEKPYKCEICLKQFSQAGTLKTHLRVHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5N8</accession>
    <name>A0ABM5L5N8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517755.1">
        <property type="nucleotide sequence ID" value="XM_050661798.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661798.1">
        <property type="protein sequence ID" value="XP_050517755.1"/>
        <property type="gene ID" value="LOC126892295"/>
    </dbReference>
    <dbReference type="GeneID" id="126892295"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="547" mass="64689" checksum="8D91EFC293BA8F7F" modified="2025-10-08" version="1">METKQEASEKTCKIETNNETHHDGPLDAFKIEITEEPKREHAYNAFDSTLDSTNVLSVKTEVEHKFTPFELKQTTNEESYYQEEKKLEIMETLPEHSSYEGNYLSRHDEGRALTQNNTVATRQRPDKCEVCFKKFSRNEHLKNHLRIHTGEKAYKCDICFKQCSYASNLKKHLRVHTGEKPYKCEICLKQFIQGGDLKTHLRVHTGEKLYKCEICLKQFSQVSNLKTHLRLHAGEKLYKCEVCFKKFSRKVDLKRHLRVHTGEKPYKCDICFIQFSESDNLKTHLRVHTGEKPHKCEICFKQFIQANNLKTHLRVHTGEKLYKCEICFKQFSHASSFNAHLRVHTGEKLYKCEICFKQFSQASNLKTHLRVHTGEKLYKCEVCFKKFSRNDHLKIHLRIHTREKPYKCDICFIQFSEEGHLKKHLRMHTEKKTYKCEICFRQFIQASNLKTHLRVHTGEKPHKCEICLKQFIQASNLKQHMSVHSGKRPYKCEMCLKQFSRTSHLKTHLRVHTGEKPYKCEICFKQFGQAGGLKRHLKVHTRKDLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6H1</accession>
    <name>A0ABM5L6H1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518032.1">
        <property type="nucleotide sequence ID" value="XM_050662075.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662075.1">
        <property type="protein sequence ID" value="XP_050518032.1"/>
        <property type="gene ID" value="LOC126892517"/>
    </dbReference>
    <dbReference type="GeneID" id="126892517"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="133" mass="15146" checksum="74D9EF2E6B15F052" modified="2025-10-08" version="1">MEVVDIEGKRGRRVPVIITPELKSAIDLLIKTRSTVNISKNNPYIFAPAESEIGHLRGHDCLKSMCNEVNLQHPEYITGTKLRKYIATVSQIFNLGKNEADWLARHLGHDIRVHRDFYRLHENAVEATKISAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L888</accession>
    <name>A0ABM5L888_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">chymotrypsin</fullName>
            <ecNumber evidence="8">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050518653.1">
        <property type="nucleotide sequence ID" value="XM_050662696.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662696.1">
        <property type="protein sequence ID" value="XP_050518653.1"/>
        <property type="gene ID" value="LOC126892879"/>
    </dbReference>
    <dbReference type="GeneID" id="126892879"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF65">
        <property type="entry name" value="CHYMOTRYPSINOGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045310378" description="chymotrypsin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="283" mass="32019" checksum="11A9087B2149472E" modified="2025-10-08" version="1">MKPIILCLMIIAASKAIPTNRLTNDDANLGDFPWIVALNIYVRMPWYEITYHECGGVLVSKSWVLTSASCVKSNAVWNTVTEIYAGFVRQNDPSRQSFTISRIERHPGFNMNESRNPSFDDIALVKLDRDVELNENVKIVKLPEADADITKNFTSAGWPYAAITRENQDILQLRSVPFLDYKTCYDQVAAYVALGRTEPLDEAWDNIYLNETQNICTGPKDAETAVFTKGYHGGPLVQDGVVYGVLSYTLNVYIYHKDFYEPSGVFINVFNYISWIKGIVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9S5</accession>
    <name>A0ABM5L9S5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519185.1">
        <property type="nucleotide sequence ID" value="XM_050663228.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663228.1">
        <property type="protein sequence ID" value="XP_050519185.1"/>
        <property type="gene ID" value="LOC126893238"/>
    </dbReference>
    <dbReference type="GeneID" id="126893238"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23923" checksum="F16A1D7B2511C5D3" modified="2025-10-08" version="1">MLNLSLQGRNQTVSDLIGMINGFRNKLNVFKRALEKNNLTHFPSCLQIAEEFNGEENIEFSSCISQIEQVIDEFNTRFEEIESLKSSVLLYNNPLGATIDDQPPNLQLELSDLQADMFLITRQEKGPEFFKLLSKEKFPNLRDFGLKMTSMFGSTNTCESSFSSTKYIKNKNKSNLTDSSLRHLIRLSTIELEVDISSLVDEADRPQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXD4</accession>
    <name>A0A6P7EXD4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114324230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114324230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127819.1">
        <property type="nucleotide sequence ID" value="XM_028272018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EXD4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272018.2">
        <property type="protein sequence ID" value="XP_028127819.1"/>
        <property type="gene ID" value="LOC114324230"/>
    </dbReference>
    <dbReference type="GeneID" id="114324230"/>
    <dbReference type="KEGG" id="dvv:114324230"/>
    <dbReference type="InParanoid" id="A0A6P7EXD4"/>
    <dbReference type="OrthoDB" id="6661750at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028127819.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="18545" checksum="1FE7A6BF657EBAB3" modified="2020-12-02" version="1">MGYCKDPQYKDVKQVLRNFTFRPINRTTKIMEWDLVMDRDVDNTTEARIEMERWSGGRWIKMTFLPFIRDPCVMLQQYFSEPWVTLMKKIQVEDPYSCPWKAGNYSLRNLVYSDAYCAESLIPMVGKYRFHVIYRDIKTKTIYCCLEGITSQEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZM0</accession>
    <name>A0A6P7EZM0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114324413</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128052.1">
        <property type="nucleotide sequence ID" value="XM_028272251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZM0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272251.2">
        <property type="protein sequence ID" value="XP_028128052.1"/>
        <property type="gene ID" value="LOC114324413"/>
    </dbReference>
    <dbReference type="GeneID" id="114324413"/>
    <dbReference type="KEGG" id="dvv:114324413"/>
    <dbReference type="InParanoid" id="A0A6P7EZM0"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028128052.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50123" checksum="4B705384F2852D93" modified="2020-12-02" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCMQGFQLTHSLGGGTGSGLGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSSTMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELVLQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTCIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEEEGDEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0H4</accession>
    <name>A0A6P7F0H4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PP2C-like domain-containing protein CG9801 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325261</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129069.1">
        <property type="nucleotide sequence ID" value="XM_028273268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F0H4"/>
    <dbReference type="FunCoup" id="A0A6P7F0H4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273268.2">
        <property type="protein sequence ID" value="XP_028129069.1"/>
        <property type="gene ID" value="LOC114325261"/>
    </dbReference>
    <dbReference type="GeneID" id="114325261"/>
    <dbReference type="KEGG" id="dvv:114325261"/>
    <dbReference type="InParanoid" id="A0A6P7F0H4"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="314"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129069.1"/>
        </source>
    </evidence>
    <sequence length="924" mass="102671" checksum="BE6AD73550B7C031" modified="2020-12-02" version="1">MPSLRKRVSSYFRQLSFHNEPRKRHNINENTFITKYLQGLIGIKEGPPIIYGKNPTDLPNYELGIYSNGPNTVIGCYSGPNGGLTTVKRIEKHLSVLADEIDYIDTPEEETDIQPILKKSPNKVCPGQPIDNTTMIIKVAGNEYCVTNRPKRHSKSHSLGSIKDFNIEIEKTKIDKSFYSNNNSESVECKNNTVCNDNQKNGDDTSKDNPKNLDDNTVRRERSSQKKSARTSVSSRREPRQNEKSNENYSLSKSKSEGNPFHHKKRGKIIQIERPITRGDDVTSTPDNFPLQNDDSALPQEWCRKSECVYGLSDSLYDRNQVTKNKNGDPIADCFGIIARSDSAILAVADGVNWGEKASIAAKSAVHGSLHYLNKTIFNDTKPFESLTIKTDESSTSSTILDEKVNLVGSTREVFVCLLRAFNCAHDLILENKGMLTTLTVAVVLPLRQKLEKRVRLPNGQERLETEAQYVCCVCNVGDTLAYIYSRKYGVRELTKGSHDINSNRDMRDALGALGPVDGINPELSNLTLSITTLQKGDIVMVASDGLTDNFDPNVCKFTVNTKNDQPPARKASTRQRPVQPQMPVEIKAPVVKPVRNLESSGQKPPVKPPRKSKTRDVNSAEKSSINSNTVSDKSSSPSVENISIQSKNNTVVEHSSVSSSNVPEAEAANKEYNRELTSNVVESSKSNSLSRNPDYENPLIAAFMSQNSIDGSPKIEKTVKPQPHAPAVAENKASSLRRQASSHSRTETLDSHRKPVTPKTPSHASKTLKTVEEKSSTVGRMEAGYKFLRSKTTIDMRSSNSKPIIRNEDGVPYITPLQRYDLQLLLMEDILKNGISGKDAPCTSARKLCENLISYTMSITSAKRHTLEDPDLYFDNKGGVLVEVNNQEKKIRRKKGLERVQNLPGKLDHVTVVAYNVGNNFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F256</accession>
    <name>A0A6P7F256_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein tramtrack, alpha isoform-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114325549</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129431.1">
        <property type="nucleotide sequence ID" value="XM_028273630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F256"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273630.2">
        <property type="protein sequence ID" value="XP_028129431.1"/>
        <property type="gene ID" value="LOC114325549"/>
    </dbReference>
    <dbReference type="GeneID" id="114325549"/>
    <dbReference type="KEGG" id="dvv:114325549"/>
    <dbReference type="OrthoDB" id="6365358at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028129431.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="54558" checksum="0DEC230BE609FFAE" modified="2020-12-02" version="1">MLPQQYCLRWRYHHSNLQTMFSQLLEREAFCDVTLACEGRTIKAHKIVLSACSTYFETILSQYEEKDPILIMKDVKYIDIKCLVEFMYKGEINVEHCHLATLLKTAEELKIKGLAEVSWRDEEQPNNNETNSNGVQTAIPQVQTVMPNSPTPSTKRKRGRPPIDDYDQTFTTPKIATVSGGINQEDAYSNDAMSSSEHDLNIWDEDQSANEGADNTEIDDPPVKVKKESHDYDDIGVDEQSNASVNESKEKLNISLQLKTSNTNSNVTTSGNASFLTPALEKEWPDVIKMNDYLNTGRRQQFWEEPFTKRVMDAIKTKNLEMKVAAELLGVSYGTLYGRYRDSYGCLKHPYRVRDFWTEQGFTDIILKLKRKEVTLFRAAEQLNVTPQTLSNYLISMSQMDTADANSSRQSNAGESYEDSDDDADSILPDGPSNNSHLFKNLVSGSATGANCPDITIVKKERNDDSKINNNSDHSDSSSDQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3X3</accession>
    <name>A0A6P7F3X3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114325637</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028129552.1">
        <property type="nucleotide sequence ID" value="XM_028273751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3X3"/>
    <dbReference type="FunCoup" id="A0A6P7F3X3">
        <property type="interactions" value="2034"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273751.2">
        <property type="protein sequence ID" value="XP_028129552.1"/>
        <property type="gene ID" value="LOC114325637"/>
    </dbReference>
    <dbReference type="GeneID" id="114325637"/>
    <dbReference type="KEGG" id="dvv:114325637"/>
    <dbReference type="InParanoid" id="A0A6P7F3X3"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF472">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028129552.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37479" checksum="29C9EE88613C6D53" modified="2020-12-02" version="1">MAEPELNVDSLIQRLLEVRGMRPGKSVQMTESEVRGLCLKSREIFLQQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPISAIIDEKIFCCHGGLSPDLQGMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYQGMNSGRPSTPQRNPPNKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4L3</accession>
    <name>A0A6P7F4L3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein bicaudal C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114326454</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130634.1">
        <property type="nucleotide sequence ID" value="XM_028274833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4L3"/>
    <dbReference type="FunCoup" id="A0A6P7F4L3">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274833.2">
        <property type="protein sequence ID" value="XP_028130634.1"/>
        <property type="gene ID" value="LOC114326454"/>
    </dbReference>
    <dbReference type="GeneID" id="114326454"/>
    <dbReference type="KEGG" id="dvv:114326454"/>
    <dbReference type="CTD" id="34946"/>
    <dbReference type="InParanoid" id="A0A6P7F4L3"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22420">
        <property type="entry name" value="KH-I_BICC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22421">
        <property type="entry name" value="KH-I_BICC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054727">
        <property type="entry name" value="BICC1_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047549">
        <property type="entry name" value="BICC1_KH-I_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047554">
        <property type="entry name" value="BICC1_KH-I_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22985">
        <property type="entry name" value="KH_BICC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24234">
        <property type="entry name" value="KH_BICC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="708"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028130634.1"/>
        </source>
    </evidence>
    <sequence length="802" mass="90092" checksum="A48E00F1307C28C7" modified="2020-12-02" version="1">MACNFLPTRVLDINKNSDTLSEASECGTTTSEWTSNWDSKEELRDLLSKLGLKEVSDLHQERFRVDRKKLEQMLTGDNEALIPADVFFAKIMEDTDTYITWPNKLKIGAKSKKDPHVRIAGRPEDVKAAKERIVILLDTKCNRITMKMDVSYTDHSHIIGKGGLSIKRVMEETQCHVHFPDSNRSNPTEKSNQVSISGDINGVEGARSRVRELIPLIFGFELPIMTQNIDATSLYIVKIQEQYNVQVMFKTRPKLHATLVLVKGVEWEVDSVKHATTLLMEYMCENLANQIPVQMSMEISPHHHQVVLGKNHSNLKTIMQYTNCQIMFPDAQDPNIPNLKKSNVNISGNINDVYKARQLLMGSLPLIIIFDLPEESTILRTRQDQIADIQTNYDVTITIRQKAKQNTRACVIKGVEKNAGNIYKARSYILGFDEPCTTADIPPSYHLPQSLATPPIAQSANPSLSLPPQNTSNMHPISPVVSPLLSPSWPHPATPTGQNGPPFVGLMKQPQFVYNMSHQSMGSSGYHSINQTQFTASSLVLEQSGEVSNYSPISSNNSSFSSNSPRNSGSPYHRQYMEPQNQRNDLSSVLSEMNFSPGYHGTSVDRRQDKNNLVPIDLENKRMAGYRAMQNKAVTGSYRQPTNSWSGYYISHTSPTPLVDTLRQKKEEEVWNTPPKRTNSYSNISAALNTSNILEHTPSHVLNNLISSDWPDLPTMLTSLGLERYINLFTTHEIDLMIFSTLTDKDLIEIGINTFGVRRKILLAISELNRRSSSFSAAPGAERKNSPSKMTNTYQPANETKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F617</accession>
    <name>A0A6P7F617_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC114326919</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:78543"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78544"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-disulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:78651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:19120"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:229465"/>
            <dbReference type="ChEBI" id="CHEBI:229521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:78627"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
            <dbReference type="ChEBI" id="CHEBI:229465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78628"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-sulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:78647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:19119"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58591"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:229520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78648"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:17775"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028131184.1">
        <property type="nucleotide sequence ID" value="XM_028275383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F617"/>
    <dbReference type="FunCoup" id="A0A6P7F617">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275383.2">
        <property type="protein sequence ID" value="XP_028131184.1"/>
        <property type="gene ID" value="LOC114326919"/>
    </dbReference>
    <dbReference type="GeneID" id="114326919"/>
    <dbReference type="KEGG" id="dvv:114326919"/>
    <dbReference type="CTD" id="36563"/>
    <dbReference type="InParanoid" id="A0A6P7F617"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF27">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 22" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="19">
        <location>
            <begin position="51"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043868"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045476"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047548"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048609"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_028131184.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="58823" checksum="7AA046B1C4A5DAF7" modified="2020-12-02" version="1">MYMRIFKNLEYKLFHQKIIRKYSWIAPKGFDTEIKVYNCVSRQKEPLILKRKNVVTWYTCGPTVYDSSHIGHASCFIKLDIIQKILSNYFKYNVITCMNITDVDDKIIKRAFELGVKCDDLTKKYEKELWSELKSLKVEKPTIVLRVTEQIPYIISFIEKLIDNGQAYKASDHSVYFDVNTVNKYGKLQNIGSQEENKPSGVKKHVMDFALWKSRKDEDLFWKSPWGEGRPGWHIECSALASKIFGSNIDIHAGGIDLRFPHHENEEAQSCAYHDTPQWVNYWIHTGHLQLSNSEKMSKSLGNTLLIQEMLKTVSPEVFRMACTMSRYEYNMEYSEKLIATARSNYNNFKNCIQSCNEFKNGFLKASVNSELLNEHIHKCSNNIHSALCDDFDTPSVIKHLNQLVSTTNSMLHSKSFSDDQQGLVSILEVQHLISSILESFGFDMNGSEAVSKDFNDIVDVLNVFRQDVRNLAIVDKNKELLELCDKVRDNAKKCGITFKDRGKVSSWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8T3</accession>
    <name>A0A6P7F8T3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho GTPase-activating protein 21-B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114326081</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130093.1">
        <property type="nucleotide sequence ID" value="XM_028274292.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F8T3">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274292.2">
        <property type="protein sequence ID" value="XP_028130093.1"/>
        <property type="gene ID" value="LOC114326081"/>
    </dbReference>
    <dbReference type="GeneID" id="114326081"/>
    <dbReference type="KEGG" id="dvv:114326081"/>
    <dbReference type="CTD" id="33048"/>
    <dbReference type="InParanoid" id="A0A6P7F8T3"/>
    <dbReference type="OrthoDB" id="6281275at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="74"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="899"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1567"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1600"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1664"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="448"/>
            <end position="458"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="597"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="607"/>
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            <begin position="619"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <end position="825"/>
        </location>
    </feature>
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        <location>
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            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1600"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1618"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1676"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1711"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1761"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1781"/>
            <end position="1838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028130093.1"/>
        </source>
    </evidence>
    <sequence length="1934" mass="217880" checksum="7E1B9FC7E27B5549" modified="2020-12-02" version="1">MDEYGGPPNVPNAFKSQETFQRVQEAQAEHRFPNQPGIVPVPRGSRGPRSLYLRRYGDSFGFTLRHFIVYPPDSVAEQYASRHAAVGALLTPMDTIFVKNVKERSPARQAGLQRGDRLIAVNGVAVKDRSYSEVVQLIVKSPEYLHLLVVPKEEDVLQRFFAETAYNPASNQQVYPEAPPFDKHTAQQIISKRLANVPTERFQVDAISWKSLQQQPYALAADPIQRVGYERPQHSAENLYYNVPRRRVQQEIYAEIHPHDTERIARSRAAPQVPLYKKMGRRASEGNILSDSEHYNQEYSSLQPVSQDNYNNMKTVYKSSNYMPEANDMSKNPSCRHSIEVERRRESTSSLSSSITDGSKDSVTSYGSNLTLTGHETDDSAIMDRFRKSVQQKEEFLRTPVNVVDQSDVRKEFYSRPKKMEKQVWPPNERDKPSERNSKPSHQNFMRVKNDIDNERDLSGGTNQNGYPVQGGAVSNMPQQRGVTSPKERENVGLQRIYEAAMAPTGFDNMESFNGSAVDDAYYDDRKVYSPPLQIVSRRAKDFESGRPLPDDDPVQANRTNFSRSELARLSNKKLVPNVTEMAQDYEIKASEPRKDPSLTSTNSSSSILKRIQRDSRSLDSSGSNASSASVNEILFGSGSGKGLSGNVTISSGSKYLHCPPPSETQSGKPLSELVELTTRVRSNSVESWIGSLADRQRKAKDDPNKMKDSAATPELPRSPSNPPFADLPPLIPEPVEQIPVTPSLSVTPAPAHKAIRPTQLNLDGPWHLKPPNTQDSRRNLLLHLEDKPVVVKRRNKSTNLDDERATRRESYLKATEGGRMHIDSDLSDSGELSPQTLRSAHRRWRPPLFPGDIQQLRKMFEDSTYPLRGSVSSSNASLDRDKVSGGSSPLIESKELPVDVRDGILHCKILEIDGKRAADRSWKQVFVILKGPKLFLYRDRHHQSPVGTSDSLDQSLSSGVDMRTSVVRVAEDYTKRKNVLRVSSVKPCRSEFLLQADSSEDFADWVKKLQEQVAASTEAELDPQNSKQKAVPQSVPASTTIQVQGSHLSPQLNKQKPTASRNRSPTGQSPVSKSRKPSQVPEPTSTSPKSKTWRGRMVKQLRKFNQGVNNPNSPTAPEGSTFGIPIEDCIPSATNMYLPKFVEVCTDIIDERGLQTVGIYRVPGNNASITALSEEINKNYEDVPLEDPRWNDLHLVSSILKSYFRKMPNSLITIQLYPSFIKADKIENPKERMEQLRRLVKSLPRHNYHTLKHIVMHLRRVGNNSNVNKMDFKNLAIVFGPTIVRPEEENMESMVNHMNNQYKIVETLLTHADWFFPENESEDNLPVPDSLNDGLEEFDNNNQSLLLNNIGKYGALTHPKEKNGALFSTIISAAQRKVKRKPNKALSSTQESKEEIVSPTNLKVFPTQSFLPTDLKECSLPDEKTQDIPTTVMDIEKKNTSSAEKVPWFKYSDADEFHRRIENFKQETQAMLQLPRKTEICISNIDPRTMGQYSSTSAGNVNRSNRLSTAKEPEGHHLMKTHSATNVFSRTGNSAELNRNSLATMDNYSVQYNKNGNDYQYVKQSGASNKVTNNTRSDVTDGNSDRTVGAYRSTIRRGGSVENVSSSSVDISNGKKVKYESESDSHRTTGSLESLNKLSNDDESLLSTMTKLIDEKLKEDTSILSGDGIPFVDESPEKHPKNSYPDKENIPQASDLYRNPSLHKNQLKMSKKEDKEYKNDKEKEVDTMAMEKVPDNDRNIAKTLVFSNNNKLNQSGTKLRRSESLNKPERTVSPLSNKLKRSESLNKAGDRLKRSDSLSKSEKTESNINRKREINLSNRRVKDSVKNKRKNGMPDRSIKRRHTVGGTKDPDKITWVMDNKNQQADSNQETKKEKNLRTSSPDLSSMRRDRFFFEINLIGPENMVVALRQHLVGARPQSFPESSVFKVPLESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCF9</accession>
    <name>A0A6P7FCF9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114326873</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028131128.1">
        <property type="nucleotide sequence ID" value="XM_028275327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCF9"/>
    <dbReference type="FunCoup" id="A0A6P7FCF9">
        <property type="interactions" value="1569"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275327.2">
        <property type="protein sequence ID" value="XP_028131128.1"/>
        <property type="gene ID" value="LOC114326873"/>
    </dbReference>
    <dbReference type="GeneID" id="114326873"/>
    <dbReference type="KEGG" id="dvv:114326873"/>
    <dbReference type="CTD" id="417"/>
    <dbReference type="InParanoid" id="A0A6P7FCF9"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="179"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131128.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41354" checksum="B0DEBF94DBCAC724" modified="2020-12-02" version="1">METMEVAPTAVLNNHVTKGEKMEDIPAEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHLFAGKVVMDIGCGTGILSMFAAKAGAKKVLAVECSNIVDYAKQIIETNKLDHIITIVKGKVEEITLPDGIEKVDIIISEWMGYCLFYESMLDTVLFARDKWLQPDGLLFPDRCSLFVTAIEDRQYKDEKINWWDDVYGFDMSSIRKVAISEPLVDVVDPKQVVTGPALIKEVDLYTVKKEDLDFTSPFMLTVRRNDYVQALVTYFTVEFSKCHKRIGFTTAPDAPYTHWKQTVFYFENYMTVKKNEEIHGMFTMKPNPRNNRDLDFVIELHFKGELGEVHEVNRYRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDB9</accession>
    <name>A0A6P7FDB9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RUN and FYVE domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114328896</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133676.1">
        <property type="nucleotide sequence ID" value="XM_028277875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDB9"/>
    <dbReference type="FunCoup" id="A0A6P7FDB9">
        <property type="interactions" value="1631"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277875.2">
        <property type="protein sequence ID" value="XP_028133676.1"/>
        <property type="gene ID" value="LOC114328896"/>
    </dbReference>
    <dbReference type="GeneID" id="114328896"/>
    <dbReference type="KEGG" id="dvv:114328896"/>
    <dbReference type="InParanoid" id="A0A6P7FDB9"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="8">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="604"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="288"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="372"/>
            <end position="427"/>
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    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="456"/>
            <end position="507"/>
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    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="536"/>
            <end position="591"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50826"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028133676.1"/>
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    </evidence>
    <sequence length="670" mass="76818" checksum="41AD3914DD5C6B6C" modified="2020-12-02" version="1">MKVQELPAEAGPNGMEQEMAGAQDTIYLCNFRVSVDGEWLCLKELQDVEFNMQESITKALSTPSPEIPVQPFGRDPVVIERSNLVNISKLVVKELIEQSLRYGRMLDSDHMPLQHFFIVLEHVLRHGLRPKKGLLGPKKELWDILQMVEKYTPEAQDITASVRDLPTVRTHMGRARAWLRLALMQKKLADYLKVLIDHKDEALVEYFEPDALMLSDEAIIIIGLLVGLNVIDCNLCVKEEDLDCPQGVIDFSLYLRSSSHVSTDSSNEEQGDAMITVLDQKNYIEELNRHLNATVANLQTKVESLTTTNALMKEDLAIAKNNLLALYDENRQLRLELGKESDGYALGISGVQITKVEEKETKEISKLVGSEVEELKHRLEEERKLRQEADNELEIQMCMKAEMEVAMKLLEKDIHEKQDTIISLRRQLDDIKLINLEMYKKLQESEASLRHKTEFITKLEAKAQSMTDTIQSLENKYRESESNRVTAEQLKREVDMQAAQVEEQATNIEGDLKVEREWRISLQATMQQDRERISKLQIENGQLKMIAQKYAQLQEEYYTLKDQCLEQEHTLEELGGHLRESKLQISDLREEITKSRPEGSWAKDHTAAKCKACTKEFNLTRRRHHCRNCGEIFCNACSDNTMPLPSSAKPVRVCDDCHLILLGRTNSVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FED6</accession>
    <name>A0A6P7FED6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein kinase C</fullName>
            <ecNumber evidence="5">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC114327327</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="29">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028131720.1">
        <property type="nucleotide sequence ID" value="XM_028275919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FED6"/>
    <dbReference type="FunCoup" id="A0A6P7FED6">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275919.2">
        <property type="protein sequence ID" value="XP_028131720.1"/>
        <property type="gene ID" value="LOC114327327"/>
    </dbReference>
    <dbReference type="GeneID" id="114327327"/>
    <dbReference type="KEGG" id="dvv:114327327"/>
    <dbReference type="CTD" id="42203"/>
    <dbReference type="InParanoid" id="A0A6P7FED6"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20795">
        <property type="entry name" value="C1_PKD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20796">
        <property type="entry name" value="C1_PKD_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01239">
        <property type="entry name" value="PH_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14082">
        <property type="entry name" value="STKc_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000151">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000137">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000021">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015727">
        <property type="entry name" value="Protein_Kinase_C_mu-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057764">
        <property type="entry name" value="Ubiquitin_PRKD1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25525">
        <property type="entry name" value="Ubiquitin_PRKD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000552">
        <property type="entry name" value="PKC_mu_nu_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 29" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 21 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="26">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="24">
        <location>
            <begin position="379"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="523"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="529"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 22">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000552-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000552-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_028131720.1"/>
        </source>
    </evidence>
    <sequence length="816" mass="92563" checksum="CE9D6C51C3A77AF8" modified="2020-12-02" version="1">MDNQKLEVTFLFQFGLIRDTITVPQASLNLKTVKNLAVSFLNSKIPDHGVNRIEDRILLFRHAYSSNNILQLINSALEISDETLIEIVLTAKEISGPHVPEITIVRPHALSVHSYKAPTFCDFCGEMLFGLVRQGLKCDGCGQNYHKRCVIKVPNNCSYNLLDENEKQRRRSTSANLQVPRSPSGGSNTSLASASSTQTEDSGLFQSNNRSPSLGGRPVWVEKEMSSRVKIPHTFVLHTYTRPTVCQYCKKLLKGLFKQGLQCKDCNYNAHKKCLQKVPKDCTGELPRDASGNFEHSSSCASIDSHFNSALDEDSETTKESSVSLNNDNDSNKYIEVIPVHDDDDNDLTPSSSSSSPSANIPLQRIVQSVKHTKRRGSKVIKEGWLVHFTNKDKTVRRHFWRLDTKSIVLFQSEQSSKYYKEIPLSEILTIDTARIKQGEYMHCFEIRTANIDYFVGQDPLFNLQDGNLVNLPPPDSGVGAYLAKSWESSIRQAIVPVQANQKHEETSASEEQITDMSQLYQIYPDEVLGSGQFGIVYGGAHRRTTRAVAIKVIDKLRFPTKQEAQLKNEVAILQNLSHPGVVNLERMFETPERIFVVMEKLKGDMLEMILSHDKGRLTERVTKFIITQILIALKHLHSKNIVHCDLKPENVLLSSDAEFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINEQIQNAAFMYPPNPWKEISSDAINLINNLLQVKQRKRYTVDKSLSHIWLQDYQTWCDLRTLENQVGVRYLTHESDDQRWEQYRAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEP7</accession>
    <name>A0A6P7FEP7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Target of rapamycin complex subunit lst8</fullName>
            <shortName evidence="7">TORC subunit lst8</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114327416</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of TORC1 complex. Part of the TORC2 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131830.1">
        <property type="nucleotide sequence ID" value="XM_028276029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEP7"/>
    <dbReference type="FunCoup" id="A0A6P7FEP7">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276029.2">
        <property type="protein sequence ID" value="XP_028131830.1"/>
        <property type="gene ID" value="LOC114327416"/>
    </dbReference>
    <dbReference type="GeneID" id="114327416"/>
    <dbReference type="KEGG" id="dvv:114327416"/>
    <dbReference type="CTD" id="31903"/>
    <dbReference type="InParanoid" id="A0A6P7FEP7"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032535">
        <property type="term" value="P:regulation of cellular component size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000505">
        <property type="entry name" value="Blast:Protein LST8 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131830.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35813" checksum="8E4591671127D752" modified="2020-12-02" version="1">MTIETLENDNIILATGGYDHTIKLWQTHTGICTRTLQHAESQVNALEITPDRQHLATASYQHIYMYDLTSNNPNAIVNYEGTSKNVTCVGFQEDGKWMYSGGEDSRARIWDLRSRNNQCPKIFEVQSAINCVALHPNQVELFVGDQNGIIYKWDLRTDHNEQLIPENDAMILDVEVSPDSQLMASVNNKGRCYIWSLISGMIDTPTKMIPKQKFEAHTRHTLKCKFSPDSNMLVTTSADTTARIWNCADFSLLQELKQPESQRWVWDADFSADGQYIFTASSDGCARLWNVKTGAMERDYTGHQKAVTALAFRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEX6</accession>
    <name>A0A6P7FEX6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein DDB_G0280579-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329410</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134301.1">
        <property type="nucleotide sequence ID" value="XM_028278500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEX6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278500.1">
        <property type="protein sequence ID" value="XP_028134301.1"/>
        <property type="gene ID" value="LOC114329410"/>
    </dbReference>
    <dbReference type="GeneID" id="114329410"/>
    <dbReference type="KEGG" id="dvv:114329410"/>
    <dbReference type="InParanoid" id="A0A6P7FEX6"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028134301.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25053" checksum="F8F94EC1AF412502" modified="2020-12-02" version="1">MKRTELILHLATHNLQEENSTPEKPSVLEDNNISETLNDAVILAELKPVNLNPNSSSLDPNLMILHKPCELGPDNLRISNNLQKENSTPDEPSVLEDNNISETLNNDAVILSELQPVNLNPNSSSQYSNNNLRISNNYETQPSSSYSVETHSSTKITLRKMSRTVYDGQHASDDENSLFGEDSDNYVPSENIISSESETNLTPTIKEKKRPRGLFSEYENGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ34</accession>
    <name>A0A6P7FJ34_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S-phase kinase-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114328538</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133215.1">
        <property type="nucleotide sequence ID" value="XM_028277414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJ34"/>
    <dbReference type="FunCoup" id="A0A6P7FJ34">
        <property type="interactions" value="1877"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277414.2">
        <property type="protein sequence ID" value="XP_028133215.1"/>
        <property type="gene ID" value="LOC114328538"/>
    </dbReference>
    <dbReference type="GeneID" id="114328538"/>
    <dbReference type="KEGG" id="dvv:114328538"/>
    <dbReference type="InParanoid" id="A0A6P7FJ34"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000018">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133215.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18523" checksum="02B685F34A48124C" modified="2020-12-02" version="1">MPNIKLQSSDGETFEIDVEIAKCSVTIKTMLEDLGMDEEEEEVVPLPNVNSAILRKVIQWATYHKDDPPPPEDDDNKEKRTDDISSWDADFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKAPEEIRKTFNIKNDFTASEEEQVRKENEWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK28</accession>
    <name>A0A6P7FK28_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC114331193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114331193</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136488.1">
        <property type="nucleotide sequence ID" value="XM_028280687.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136489.1">
        <property type="nucleotide sequence ID" value="XM_028280688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK28"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280687.2">
        <property type="protein sequence ID" value="XP_028136488.1"/>
        <property type="gene ID" value="LOC114331193"/>
    </dbReference>
    <dbReference type="GeneID" id="114331193"/>
    <dbReference type="KEGG" id="dvv:114331193"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650942" evidence="1">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028136488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028136489.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18185" checksum="5EFDCB3877DA4A9F" modified="2020-12-02" version="1">MKLNLVIFIGICIICGIRYSEAGCCPKPKPVEITDANIAAVGDCLKGLVNTYRNQDRIKKIIIERVTTIKEKFIVTVQTRGLFSGFQNIIRNFYNGAASIIHLLLPRNKDLFDVTANTMKRILKYCIRNNPSLLDVAQKIVLAGTSIARIACDTFIKQLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMU4</accession>
    <name>A0A6P7FMU4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L53, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114331954</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137446.1">
        <property type="nucleotide sequence ID" value="XM_028281645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMU4"/>
    <dbReference type="FunCoup" id="A0A6P7FMU4">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281645.2">
        <property type="protein sequence ID" value="XP_028137446.1"/>
        <property type="gene ID" value="LOC114331954"/>
    </dbReference>
    <dbReference type="GeneID" id="114331954"/>
    <dbReference type="KEGG" id="dvv:114331954"/>
    <dbReference type="CTD" id="116540"/>
    <dbReference type="InParanoid" id="A0A6P7FMU4"/>
    <dbReference type="OrthoDB" id="6618793at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052473">
        <property type="entry name" value="mtLSU_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33618:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028137446.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15158" checksum="4EC838EF71D1B2CD" modified="2020-12-02" version="1">MSIYFSGGFTRSAGIISAINKQLKLVNLKPVKKIQVQFDPFHANAVTARDFLFHISTPKVIETNLSCVIKPNVVCDRSEPEIKIDLGDAGTVKFLANNLTVLEILQQFNKHISSKVPVEPVASPITTKLEAKRKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNL1</accession>
    <name>A0A6P7FNL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-ureidopropionase</fullName>
            <ecNumber evidence="6">3.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-carbamoyl-beta-alanine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114329621</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:37339"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57731"/>
            <dbReference type="ChEBI" id="CHEBI:74414"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-(carbamoylamino)propanoate + H2O + 2 H(+) = beta-alanine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:11184"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="3.5.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbon-nitrogen hydrolase superfamily. BUP family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.6" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028134593.1">
        <property type="nucleotide sequence ID" value="XM_028278792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNL1"/>
    <dbReference type="FunCoup" id="A0A6P7FNL1">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278792.1">
        <property type="protein sequence ID" value="XP_028134593.1"/>
        <property type="gene ID" value="LOC114329621"/>
    </dbReference>
    <dbReference type="GeneID" id="114329621"/>
    <dbReference type="KEGG" id="dvv:114329621"/>
    <dbReference type="InParanoid" id="A0A6P7FNL1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000008">
        <property type="entry name" value="Beta-alanine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028134593.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43507" checksum="0F70B26371771EE2" modified="2020-12-02" version="1">MSAIELDSIESVLKTLSIEDYEKVCGLLYGKGVSKITLKEEVLHLAEKYDIEVAIEKFISQEEQLRSPRNTRVGLFQHKTPLPTWSRIKEMRDAMFKLASEALEIAYKGGVNVFCFQEAWNMPFAFCTREKSPWCEYAEEAEHGPTTEFLKGLAKRYNMVILSSILERDSVHGDTIWNTCVVIDNHGEYLGKHRKNHIPRVGDFNESTYYFEGNTGHPVFKTEFGKIAINICYGRHHPLNWLGFALNGAEIVFNPSATIGGLSEPLWGVEARNAAIANSYYTCAINRVGTEVFQNEFTSGNGQPAHKDFGHFYGSSYVTAPNGSRTHGLSRTRNGLLIAELDLNLCRQVRDVWGFQMTQRLDMYADLLKEAIKPDFKPQLIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUW8</accession>
    <name>A0A6P7FUW8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114332968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114332968</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138577.1">
        <property type="nucleotide sequence ID" value="XM_028282776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282776.1">
        <property type="protein sequence ID" value="XP_028138577.1"/>
        <property type="gene ID" value="LOC114332968"/>
    </dbReference>
    <dbReference type="GeneID" id="114332968"/>
    <dbReference type="KEGG" id="dvv:114332968"/>
    <dbReference type="InParanoid" id="A0A6P7FUW8"/>
    <dbReference type="OrthoDB" id="6672161at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.10">
        <property type="entry name" value="Pesticidal crystal protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56849">
        <property type="entry name" value="delta-Endotoxin (insectocide), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028138577.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58450" checksum="A4481475909AF50B" modified="2020-12-02" version="1">MSRPNTNCFQVLPNNSRWLSTQDSGIFPKRHTDYYVFNMGRQEVLVEGWWGTKLGWTGVLDGVNLAPGNGYRIVVSDKPYFVTAVKITNKTTVRALMHCSEINGYPLRSQGTDSIRPDISSIAKYFIPFGVGKISEINMGFKSLENFFWPKGGESVWDKIAKQIVFLLNEATQKRIKQILREDILLVQENLSLLQSQINSFQPSVVKAEFFIKMAEQLVFLEKKFSDCGDSDIDLNFHLLPLYSATVNFKVLLYTIACERHREVGLNDEQIGRIIQFSEKLINDPYLGSVAHITKTFEDKFHLEYRTCDQELIYNILATIRTWCGINGEEYVPFWRSLLDKKKIFYNGVITYSAYFGTPSPQLYYQLVTDDVSPPLQPRIINEKRNVMNGIYVYIWRTTTNEGAAKIGGLKIMYQNGDSVETGKATGESNYVNLKKTFLKKVIVWGGEGINCIEFYLSNGNVECFGTKEGSPNSAKFKLLGHKIVGLCMKTDIPGSNGQAVNISVAYQVLEKHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYZ1</accession>
    <name>A0A6P7FYZ1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine-rich glycoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335702</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141784.1">
        <property type="nucleotide sequence ID" value="XM_028285983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYZ1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657397.1">
        <property type="protein sequence ID" value="XP_050513354.1"/>
        <property type="gene ID" value="LOC126889278"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FYZ1"/>
    <dbReference type="OrthoDB" id="10638449at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027670311" evidence="2">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141784.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18902" checksum="ABF437D66B1343EA" modified="2020-12-02" version="1">MAKLMISILLLAVTLSIQAAPQPGHEYKDHGYGPPDHGHGKIEHGYGHDHKDYGHDHKEHHYEPQKHEYGHQKHEEHGYGHDHKDYGHGYKEHHYEPQKHEYGHQKHEEHGYGHDHKDFGHGYDHDHQKHDFGHPPHDYKPPHGQDYHKKPHDYPHPHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0H2</accession>
    <name>A0A6P7G0H2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114334659</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140557.1">
        <property type="nucleotide sequence ID" value="XM_028284756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0H2"/>
    <dbReference type="FunCoup" id="A0A6P7G0H2">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284756.2">
        <property type="protein sequence ID" value="XP_028140557.1"/>
        <property type="gene ID" value="LOC114334659"/>
    </dbReference>
    <dbReference type="GeneID" id="114334659"/>
    <dbReference type="KEGG" id="dvv:114334659"/>
    <dbReference type="InParanoid" id="A0A6P7G0H2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028140557.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20402" checksum="D0CAF651AAAA6000" modified="2020-12-02" version="1">MGLTISAVFNRLFSKKPMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQTRIRKLWRHYFANTDGLIFVVDSNDRDRIAEAEEELHNMLGEDDLRDCILLIFANKQDLPNSMSTAELTDKLKLHTLKNRRWYIQATCATQGNGLYEGLDWLSNELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0H5</accession>
    <name>A0A6P7G0H5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Glutamate receptor ionotropic, kainate 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC114336185</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142316.1">
        <property type="nucleotide sequence ID" value="XM_028286515.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502838.1">
        <property type="nucleotide sequence ID" value="XM_050646881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0H5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646881.1">
        <property type="protein sequence ID" value="XP_050502838.1"/>
        <property type="gene ID" value="LOC114336185"/>
    </dbReference>
    <dbReference type="GeneID" id="114336185"/>
    <dbReference type="KEGG" id="dvv:114336185"/>
    <dbReference type="InParanoid" id="A0A6P7G0H5"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000178">
        <property type="entry name" value="Glutamate receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000061">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027709262" evidence="19">
        <location>
            <begin position="21"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="416"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="426"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="681"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="739"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028142316.1"/>
        </source>
    </evidence>
    <sequence length="916" mass="104271" checksum="7DE9365AEF1360F5" modified="2020-12-02" version="1">MVTKFYYLFLLLISVKVGLCSERETYTIGIIFNEMPNDAEYPLNDTIIRTNIIEKHSPIYLAANIQTTSKTDIFDTSKVVCNLVDDGIVAVFGPPTSVTSPVIESTCKSLNIPYIVTSWRKTNLDESDVFLNFYPDADKLAKGISEVVKSLEWIGFIILYEDEEGLVKLQEVLKLQNVEKMDNQDYIRVEQLTNGPDYRHIFKKFKNSTENNVILDCKTENILPILAQAKSLDMVDIRYNYFLTSLDAHTIDFSSLNVTANITTIRIFDSDNENFLSAIQKWNIAAVEFNRKTMTIDPDTLKTETLLFHDALVYLSTTLKDMPYISNAKVNCFGMDIYLDGPDIIRSTKEKNDLATITGPIKFDDSGNREYFNLYVYTQLDDQLIATYIAENETLKLMRTSEETNLAAISSLKKVNVIVSTRVGEPYLMLAESPDGKVLEGNDRYEGYTKDLMNEIAAILEFKYEIMITENNVYGKYLADEKRWNGLIGDLLEGNAHLALCDLTINQQRRSIVDFSMPFMTLGISILHKSPQKSDSKPFAFLDPFDTSVWIYSATTYLVVSIILFFIARMTPGDWENPHPCDQEPTMAENIWSLRNCHWATLGTIMNQGCDILPKGISTRLALAMWWFFALIITNSYIANLTAFLTKANLDSPIKSVDDLGKQSKIKYGFLEGGATEQFFRESNNSLYQRMYLNMKSARPSVLETDNLDGVQRVQNTKNELYAFLMESTTIEYHTATKCNLKQVGDWLDSKSYGIAMPMNANYRSAIDKAILQLQETGALNALKQKWWKEKRTDTLCEVLRNLDKDDNEGDLDLAKTSGIFLVLVVGVSIALAMGWIEFLWNVRNISVEEHMTYWEALKMELKFAFNIWITRKKIKPDVSESSASSESKSEKIDNRSMIQNFLHNAGSFMNVNQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2J8</accession>
    <name>A0A6P7G2J8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Active regulator of SIRT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S19-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114335232</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AROS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141232.1">
        <property type="nucleotide sequence ID" value="XM_028285431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2J8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285431.2">
        <property type="protein sequence ID" value="XP_028141232.1"/>
        <property type="gene ID" value="LOC114335232"/>
    </dbReference>
    <dbReference type="GeneID" id="114335232"/>
    <dbReference type="KEGG" id="dvv:114335232"/>
    <dbReference type="InParanoid" id="A0A6P7G2J8"/>
    <dbReference type="OrthoDB" id="6493910at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023262">
        <property type="entry name" value="AROS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31454">
        <property type="entry name" value="ACTIVE REGULATOR OF SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31454:SF2">
        <property type="entry name" value="ACTIVE REGULATOR OF SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15684">
        <property type="entry name" value="AROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02029">
        <property type="entry name" value="ACTREGSIRT1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141232.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16650" checksum="90E7FE64985C4805" modified="2020-12-02" version="1">MMSAALVRKSLQIVDPQYASKIGKRKSKSDVFALAHQSQKLIGKAQRKGKTEKVNLLSTEKKLTVTEARKYNKSKEQILKDNLKKLELIKRASKVELDEKLVKQIINRAVSRRPIKKIKPKQQKKTAFTEEDFKKFEEEYFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G460</accession>
    <name>A0A6P7G460_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC114335721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114335721</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141807.1">
        <property type="nucleotide sequence ID" value="XM_028286006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G460"/>
    <dbReference type="FunCoup" id="A0A6P7G460">
        <property type="interactions" value="982"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653529.1">
        <property type="protein sequence ID" value="XP_050509486.1"/>
        <property type="gene ID" value="LOC126886575"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G460"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028141807.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15543" checksum="6345CF37EB1B7399" modified="2020-12-02" version="1">MNSVHFPRIIKSCNFIARRFIGVTQSRLKSFKVQDDQDFLEKVEKSKDPIIVDFFANWCGPCKALEPRLQNVIAQRKGQISLAKVDIDDLGELAAKYEVSTIPALVVFQDGKVKERLVGLQDEDKLNTWIDHVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G610</accession>
    <name>A0A6P7G610_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114338085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114338085</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144471.1">
        <property type="nucleotide sequence ID" value="XM_028288670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G610"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648364.1">
        <property type="protein sequence ID" value="XP_050504321.1"/>
        <property type="gene ID" value="LOC126883120"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G610"/>
    <dbReference type="OrthoDB" id="7021379at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027640954" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028144471.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13304" checksum="D6A67F07A7F86327" modified="2020-12-02" version="1">MKQILILSIVCVLAVHFVSSVSLQKGTLDIIEGNCTSPNPKQAVLKDYVHKTSIPFVKRDETVEWHGDQKIYCVTAISLKSAEKGSTAWISDGGVNHTYIAIELESGRGHGLEYNVTIYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6N4</accession>
    <name>A0A6P7G6N4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Facilitated trehalose transporter Tret1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114338331</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144719.1">
        <property type="nucleotide sequence ID" value="XM_028288918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6N4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644598.1">
        <property type="protein sequence ID" value="XP_050500555.1"/>
        <property type="gene ID" value="LOC126880611"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G6N4"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028144719.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52904" checksum="3FFFEE1F18EEE24C" modified="2020-12-02" version="1">MVNVVNAEKNQGWKNEQEKTWPQIYAVLISTMAGIANGQFYAWASPFMVQIINDKVNYNITEEQASYFNTINPIFTVLMSPLCSTLTDNLGRKKTILLIAVPQISSWVCAALATDVYLFYVSRAFAGIADAMFFAALPPYVGEITTPAVRGKWGNLLAGSYYIGEFSINVIGSYFGVVTSSYICLPLPIIFFILFSMIPESPYYYLIKGNEEEAKKSLIYFRGDKNIDQYLNQLKNDVERQMSESGTWGDLFKIKSNRKALFAAVFLRFTQHACGLGILITFTQFIFQKSGGNLSHELSSIIYTGVQMILNFIVLTFIMQRFGRRGCYMTSTGVNGIVLFFMATYFYLNDYTNIDVSSFNWFPVASTVVYQIFASFGLNVIPTLMMSELFSVSIKTKAIVLAVLMFGAAGALINYLFYLINTSVGFFAPFYLFAFCNIVTAIITYFILPETRDKTLEDIQQALKNKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAV3</accession>
    <name>A0A6P7GAV3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-binding protein Ewg-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114339958</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146446.1">
        <property type="nucleotide sequence ID" value="XM_028290645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAV3"/>
    <dbReference type="FunCoup" id="A0A6P7GAV3">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290645.2">
        <property type="protein sequence ID" value="XP_028146446.1"/>
        <property type="gene ID" value="LOC114339958"/>
    </dbReference>
    <dbReference type="GeneID" id="114339958"/>
    <dbReference type="KEGG" id="dvv:114339958"/>
    <dbReference type="CTD" id="30975"/>
    <dbReference type="InParanoid" id="A0A6P7GAV3"/>
    <dbReference type="OrthoDB" id="10031051at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="8">
        <location>
            <begin position="68"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028146446.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="59236" checksum="7E78B7AD229D5E5B" modified="2020-12-02" version="1">MVLIMNNSNGNQNTEQIAMVVGSPGGMSVASDDDDNCPSSPGSAYDEGSDLMAAAMGDEVTAQLAAAGPVGVAAAAAIVSSKKRKRPHSFETNPSIRKRQQNRLLRKLRQTIDEFATRVGQQAIVLVATPGKPNTSYKVFGAKPLEDVIKNLRGMIMDELDTALATQAPPPIQEDPTLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDEKQKISWTHALRQIVINCYKFHGREDLLPAFTEEDEKANQAATANANVSTSVGVLKMHSSGMVPTHKIQIQANGSPQIIAASPDGLSGSSTQVCLDPSGYSSDVDITTQYTPAVLHTITNPDGTVSIVQVDPNNPIITLPDGTTAHVQGMATLQSAQGDGNQVHAIQTITEGGAAGEVVDLNSVTEATLNSEGQIILTAEDGHVSGVITVPVTAYHSMVANIQALHASSDGTVCVAPVVQVPKVEPNSSDNMDTLTVTPNGITTHSMMIQGSAGEAPQVLQVLSLKDATVLTKAMQGLADVKTEETIITDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBR2</accession>
    <name>A0A6P7GBR2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of rudimentary homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114340143</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May have a role in the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the E(R) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146699.1">
        <property type="nucleotide sequence ID" value="XM_028290898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBR2"/>
    <dbReference type="FunCoup" id="A0A6P7GBR2">
        <property type="interactions" value="2310"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290898.2">
        <property type="protein sequence ID" value="XP_028146699.1"/>
        <property type="gene ID" value="LOC114340143"/>
    </dbReference>
    <dbReference type="GeneID" id="114340143"/>
    <dbReference type="KEGG" id="dvv:114340143"/>
    <dbReference type="CTD" id="43951"/>
    <dbReference type="InParanoid" id="A0A6P7GBR2"/>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2260.10:FF:000001">
        <property type="entry name" value="Enhancer of rudimentary homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY ERH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373:SF0">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016393">
        <property type="entry name" value="Enh_rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01290">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028146699.1"/>
        </source>
    </evidence>
    <sequence length="103" mass="12039" checksum="38AE8022C549F327" modified="2020-12-02" version="1">MAHTILLVQPGMNPETRTYSDYESVNECMEGVCRIYEEHLKKRNPNTPTITYDISQLFDFVDQLSDLSCLVYQKSTNTYAPYNKDWIKEKIYILLRQAAGHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GET5</accession>
    <name>A0A6P7GET5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114336425</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028142590.1">
        <property type="nucleotide sequence ID" value="XM_028286789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GET5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286789.2">
        <property type="protein sequence ID" value="XP_028142590.1"/>
        <property type="gene ID" value="LOC114336425"/>
    </dbReference>
    <dbReference type="GeneID" id="114336425"/>
    <dbReference type="KEGG" id="dvv:114336425"/>
    <dbReference type="InParanoid" id="A0A6P7GET5"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF183">
        <property type="entry name" value="MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="60"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028142590.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="31087" checksum="8E3942D67ED7668D" modified="2020-12-02" version="1">MAESLENVPKIEHPLCDDIAHLGVAPEQEGKAKAAFVDVPVTLDPHYDRALEEPYLLQIFSSLEILGEGYFGTVYKARHKFDNKTYAVKKLKSEKISDAEKLKEIRNFEKVGCHPHIVNYIMGWEEGAEIYLMMQVSQTSLANYIKITNDVPEFVFWDCIHDVCLASMYMAEKRLVHYDVKDDNILIHRKHFKLADFGTVVEIKEDMLDEKCLVGDRWISRTHEVTIHKTQQRSKSTSNLNDNDGLWQVSCDSLNAVELGRILFCGSSDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNL0</accession>
    <name>A0A6P7GNL0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114338956</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028145380.1">
        <property type="nucleotide sequence ID" value="XM_028289579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNL0"/>
    <dbReference type="FunCoup" id="A0A6P7GNL0">
        <property type="interactions" value="942"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289579.2">
        <property type="protein sequence ID" value="XP_028145380.1"/>
        <property type="gene ID" value="LOC114338956"/>
    </dbReference>
    <dbReference type="GeneID" id="114338956"/>
    <dbReference type="KEGG" id="dvv:114338956"/>
    <dbReference type="CTD" id="31589"/>
    <dbReference type="InParanoid" id="A0A6P7GNL0"/>
    <dbReference type="OrthoDB" id="2449614at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.130:FF:000001">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="14">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="14">
        <location>
            <begin position="75"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028145380.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="60852" checksum="F1C9C20426572623" modified="2020-12-02" version="1">MTGHAVVVWEYEIRSGYWKPYSPAVSQHLERAKGKQLTRVILSDADPTLQNYYINLRTLTQELEDTDDVVPVRRKCYSPSSPAGKGARWECSGTEHSQEWHPFDMDIQCLIEEAWATGDEMLDMSKTHLGFPYLINFSNLTQRWLNNGYLRNVRRIKQAPYPLVKVKLEELAPVTGRRSSNIRNSSRTPNSSQQGNGTKVIGSSAILNQTDGNKKSSNKKKSGKTKTGNETTPANLARQILNNLNIFSHKSNATPLFQSTENKTLLDADSSSTKSGRRPSLDTVSTYLSQESRESQATASTADLINCSGSDDGIADDLPAIVGLDPASATISQFVRISKSSEWAPRQPCPVCRQPLKPSIVVIALPCNHVLHLDCLNYALTEQQELGTHLHIQCAVCGCIYGEKHGNQPPGTMEWRRVDRSLPGHQNCRTIQIIYNIQSGIQGPDHPNPGREYYAVGFPRVAYLPDNPKGKKVLRLLYTAWQRKLIFTVSRSHTTGCEDVVSWNIPHKTEMGPSTNSHSYPDPNYLNNVIRELEALGIVEEESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR06</accession>
    <name>A0A6P7GR06_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339743</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114339743</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146215.1">
        <property type="nucleotide sequence ID" value="XM_028290414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR06"/>
    <dbReference type="EnsemblMetazoa" id="XM_050652334.1">
        <property type="protein sequence ID" value="XP_050508291.1"/>
        <property type="gene ID" value="LOC126885657"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GR06"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028146215.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49948" checksum="1C267A563CD1B24D" modified="2020-12-02" version="1">MDSIYPSTATNPIQSTLRSSEVLPGACLVCSKIFKNVQLRNRHIKRIHKLDVSIKKMNHIVCPLCEQETNLKSHENLRKHLEENHQMSIELITLEFSSEQEYETWKYMQKIETSYAKHRIVNREEHKMLYYECNRSDAYGYKPNYKVRTEKSGGSIRIKGVCPSRLVCKLRNQGQVSVSYWKTHVGHNEELRTMHLSKAEEKMIVEKVTSGVPHSRILEDSRKMETPKLGRLPLLTSIDLRNLSRKYNIHKKPDQNDMVATDLKVKEWNDNKNYVLLLKMEDDAASCLGETSIIKLGHEEEINDFVRGKLEQRNVIQEETKEEEEILRLQKEELKNFIDELDNDSFTKFMRNIQGTMCKMKEELQEKARNITKKRKMEKQYFVRIKKFKNCSLVFYLVCNSYFKGRNVLESCGRDSGTLEILIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GRT8</accession>
    <name>A0A6P7GRT8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein lifeguard 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114340017</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146530.1">
        <property type="nucleotide sequence ID" value="XM_028290729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GRT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050660047.1">
        <property type="protein sequence ID" value="XP_050516004.1"/>
        <property type="gene ID" value="LOC126890890"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GRT8"/>
    <dbReference type="OrthoDB" id="6624577at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028146530.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44018" checksum="BABA9BAAD7B29A72" modified="2020-12-02" version="1">MIPSDIAIDIDDDDFEENGQSSLERRESIKTDTEECKISIVIPVTTEDESKPSTSSAEPHSSQNPLEIAIKLTRDSRLTSLEDLDQQLTQEQIMLFQEFVRIQSRTKVTTTEIAVGSNVLDVHTEIPDVSLYPPPPYASHENSRQIYMQHSTTYSGPAPSYSEMYVTFTSERLRNQFVRKVYSILSIQLMITFGFVLLTVLYEPVKTFVSKTPVLPYLSMATLVGLLILLSCSVPMRRHYPLNAILLLIFTLAFTYTMAYVACQYSDKAVLYATGGTAIVCSSIMILAWLNFFDITTWKFFLMAAFLIVILVGVVMTVIFSFVGGSQVFSIIFGLVMTVFFSIYLLYDTQKLLGGGRIALSEEEYILGAISLYVDIMLIFNYIMLLCLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTH8</accession>
    <name>A0A6P7GTH8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114340570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340570</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147135.1">
        <property type="nucleotide sequence ID" value="XM_028291334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTH8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645370.1">
        <property type="protein sequence ID" value="XP_050501327.1"/>
        <property type="gene ID" value="LOC126881223"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GTH8"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028294518" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147135.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="22443" checksum="4F0CD70094603710" modified="2020-12-02" version="1">MKWFTCILLVGVCASQVLLAPTEEKKDLATVLLERAAARAEAIAKRIEQSGVIDKAIAGAEAIGKKIEETGVIDKALAEADALAKRVEQTGVIDKAKQTAGQLYKQVENSGIIEKAQAEAGRLYKSIDDTGVLNKAKEQANAVINSPIAESVRQKTHQVLENVGESKLGQAIAAKAEPYVQAAAKSGCALVKSANADGLRIPTDLHCQEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GXJ5</accession>
    <name>A0A6P7GXJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="15">PPIase</shortName>
            <ecNumber evidence="15">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114344134</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="RefSeq" id="XP_028150787.1">
        <property type="nucleotide sequence ID" value="XM_028294986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GXJ5"/>
    <dbReference type="FunCoup" id="A0A6P7GXJ5">
        <property type="interactions" value="2511"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644407.1">
        <property type="protein sequence ID" value="XP_050500364.1"/>
        <property type="gene ID" value="LOC126880511"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GXJ5"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000017">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028150787.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20244" checksum="E72B4A08AFFCDB20" modified="2020-12-02" version="1">MPNWNQIQAQLRHPANPVVFFDVSVGTTEIGRMIFELFADVVPKTSENFRQFCTGEFRKDAVPLGYKGASFHRVIKDFMIQGGDFVNGDGTGVMSIYGGSTFADENFSLKHDTPGLLSMANSGKDTNGCQFFITCAKCNFLDGKHVVFGRVIDGLLVMRKIENVPTGPNNKPKIPVTIVQCGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1I0</accession>
    <name>A0A6P7H1I0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-J isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114345731</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152322.1">
        <property type="nucleotide sequence ID" value="XM_028296521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1I0"/>
    <dbReference type="FunCoup" id="A0A6P7H1I0">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296521.2">
        <property type="protein sequence ID" value="XP_028152322.1"/>
        <property type="gene ID" value="LOC114345731"/>
    </dbReference>
    <dbReference type="GeneID" id="114345731"/>
    <dbReference type="KEGG" id="dvv:114345731"/>
    <dbReference type="InParanoid" id="A0A6P7H1I0"/>
    <dbReference type="OrthoDB" id="285802at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20528">
        <property type="entry name" value="CYCLIN_CCNJ-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20529">
        <property type="entry name" value="CYCLIN_CCNJ-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028152322.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="31847" checksum="7767D4F93C534207" modified="2020-12-02" version="1">MTTRNVMTKNSVFYLQKDAWTDIEEYKDDYKKVIAEREMYRLPFLHQSPQFSYRNHLVEYLKKVCIEKKLSHCCLHLAVYLLDVFMDSHSIIPERMLLVTNVCLLLAAKTEENNLTIPKISELNNVINNRYQLNDYKTLEVVILIFFHWNVMYPTAPHYVYYYIQSAIDEEDLKDKCIGMRSLFYDLHACVTEYLDKIIQSCHYMQCYKPSKLAAGIIAVSRLDIGLSCWTEQLENITDYKREDIETQISILKAKYPFVSCQKCTGVHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ID13</accession>
    <name>A0ABM5ID13_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130160.2">
        <property type="nucleotide sequence ID" value="XM_028274359.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274359.2">
        <property type="protein sequence ID" value="XP_028130160.2"/>
        <property type="gene ID" value="LOC114326122"/>
    </dbReference>
    <dbReference type="GeneID" id="114326122"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130160.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1488" mass="166212" checksum="96D3CB10FC8DB924" modified="2025-10-08" version="1">MNLGLFNRMNLKESSESKGMYSEWTSLSLTTQREGERNQSVLEKFGLPISKEITLGLVHQLASNLGITQPAEPSPLTSDKDVQWCMEVICFGLSLPLTEHEAIKDCVNVYCEWLTALLPNPKICVPQPILDDPNIYCRKIIGHLHYLFIPRKGEDWPFLYQDLGFDTIHRQAVFCHRVLRTLQQIAHESRILERETWEALLLFLLGINDTLLSPPTVKDDVADQLCERVLSVLFEIWLIACSQCFPSPPLWKTLKESCMNWRHRVALIEQWNRVNLALTSKVLLFMYGPTFPELKIGEDDLIPSGISNDCIAQSWYRFLNTIGNPVSLTKPKVISQTEKFLQFAISTDGVADPCQHPCLQSLPLIFLKAIKGIAGQVDAFLGVAQHIWWDIVVTGAGTDKIKEAPPPITHSPTPPTQRRLAKSFSVTPSSVNKGIPKTSLIGLTTSRSSAVPPLVNSGPSSTSSISSLTSFSNEPKTPLAPGRAKCNTILHLFGEWLFEAAFIGCEMPQKNIGEPKRPNSFIMDGKSSMNFSQPGSMTDSSELPTGLTIDKYESGRAEALGTLCRIMCAKKTGEEILPVYLARFYLAVLHGLKVPSNRECGECMAAILINSANLFHLDLDGVRILMPAFISALEVVLPEKDLRLSNNINKIELRKSSIQLLLSMLVLPLHFQNVIIKELINTGSNEKPVTFLQLKPKLMNLLMNALQIESDPQNTHMLLGGLFLCVQDSAIFEKVEQVTLTSTEGSNLLSSASDTASMASMASSDRSTTPDQFGSNDYDPLLLPLDSAHALFVRATYLVCHRLISSWKTDLNVSLAALELLSGLARIHIKGSDAMECKRAVKWLCDYIISQCSRPPPAHSKDLHSTIVAAFQCCSVWLLEHPYLLRDKDCLTTVLEVAELGISGTKSIGKPGEPIKMKEEKDLKPASMRVRDAAESLLTCVLEQVFYFPSECGPESISSLLDELALLKHCNSWPNSCNDQSAAVEKFRYFVTEGSVMLALLEEPLGNDKDPQPTVTLLIRGPFGRHAWTMQLRHLPRHKSGTKYHAHNACRPVVMQETPVRPVVKQKYFPDSVERVMQCKVDLSIPSLESVLSEDENIKKEIDVIQQLVNRQASVENNIHQSQVHDNLSDYAPPPVCHEFQTARLFLSHFGLLSLDEAENGQEENGHLAVIDSSANDFCNDLSLLDNMSPRTCDTVHVFYVKSQQNHAQDIVSNVLNEHELSPYFSEFIHTLGWPVEVSSHPGWTGHVSTSWKIAPVTEHECTKKQKLYDGSSHVLYWADACSEIAFVIPSQCKPIEVTSEQSSFNSTNLSSWSDKPWTDKRALSLDLDKQPVPPKRMSHKSILHPHTNTKIMVVWLESFEDHLTLPISDLLNSMNTGLEKGTNQKTSDVLVIFLHILSTGLLRVHLQGPTGRVGLASPLVDGMVVSRRALGPLVRHTAMNMARRRRLDSDSYQPPHLRRRLKIQEIVQKYKREMSKPELLTYLFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDX8</accession>
    <name>A0ABM5IDX8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130686.2">
        <property type="nucleotide sequence ID" value="XM_028274885.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274885.2">
        <property type="protein sequence ID" value="XP_028130686.2"/>
        <property type="gene ID" value="LOC114326491"/>
    </dbReference>
    <dbReference type="GeneID" id="114326491"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130686.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="207" mass="23378" checksum="B11476E881C58BB7" modified="2025-10-08" version="1">MACGDCGSCGQCCGSPCSPAMYPHAVCCMSCPPPIILPTKPEPVEPLQMPCALIKEECIPEEVALQKRYHNFYNAYNEDWHCITPSNRGPKQEPDRGRKPRSNCEDYRRRRKSPTRGCPTGFQPCYMKLSPPCNNHPCGIWVAEIQKCLPKPKKSNEYNPGPCCRPCCLHKRPSDQCCCYDFPCKAHCYDHPVGIMPKHPLNAYCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEM3</accession>
    <name>A0ABM5IEM3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MICOS complex subunit MIC13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MICOS complex subunit Mic13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131162.2">
        <property type="nucleotide sequence ID" value="XM_028275361.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275361.2">
        <property type="protein sequence ID" value="XP_028131162.2"/>
        <property type="gene ID" value="LOC114326903"/>
    </dbReference>
    <dbReference type="GeneID" id="114326903"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026769">
        <property type="entry name" value="Mic13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31816">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31816:SF3">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15884">
        <property type="entry name" value="QIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131162.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14836" checksum="8B95B850630BA190" modified="2025-10-08" version="1">MLNRFNFVKPFPQSITRFAIKAGLAATAVYYIKEQGVWKQSDESIKAYEKIKEAACPYVKEITSQIPYEIPKLPESDVASSIVKESWNKGVLVTFKFLSDLPDTTRELTAKGIDAIKQNEEVKKLLNSTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHQ5</accession>
    <name>A0ABM5IHQ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133036.2">
        <property type="nucleotide sequence ID" value="XM_028277235.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277235.2">
        <property type="protein sequence ID" value="XP_028133036.2"/>
        <property type="gene ID" value="LOC114328396"/>
    </dbReference>
    <dbReference type="GeneID" id="114328396"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22119">
        <property type="entry name" value="F-box_FBXL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047922">
        <property type="entry name" value="FBXL6_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133036.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="681" mass="76516" checksum="2D337CC43954551D" modified="2025-10-08" version="1">MSNINLLHEQLSTESCSTLIPSDDLKTNGDMCNFLPNNNICEDIVSSNSARFDTDIDTECDTPQTTTESSEKSPGMEGAKDDTEEDSLDGKLDQEADSQDDSEDPYNINNDKSFDDDDVSYEPTEYRNGVIKKSNKKKKLSSGPGRGRPRKALVTMYQSQISGDKNAIKIRIKKSNFCTQMPPSKKKSGRRKKHKVNSDTDVSDYEKRPKRSKPWSTENDVSSTQEHEPIEQSVWGDPEKLPTAVLERIFDHVVNQEGCLPSLVKFSKVCKLWRDVSVESKLWHKADLNFVKERFRTDLRLHWLILNRLMDCQDLNMGEWKIRDIQAFLEALCEHCSKLKGLNLSGWKGISPDHLKYISTECKSLERLDLSSINFTSPINAQPLVNLSQSMAGRLTHLVLAHNKIANFTQIMAAIATNCPNLHLLDISNIRTFAHNMSLLHIEKLQIGCPNLRVLRITNSQIWLAAASLTEQVASPGFPRLEELSLAGLEEDQTTTSRSVDDDCIERLLKNSTKLRLLDVRGCSKLTDSGLVRVPAWDLEHLFLSACYITRLQNSGLELIVQKWSHSLVEVDLAWSTATNPLDAAVLALAEKGSESKIRFLNLCGSSVSLEPVKAVLEKCPRLYSINLQSCRALPRGIKRLYTGSQVDELRKSLQDKPKTEAIESETDQSPAQTTVSPRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJ51</accession>
    <name>A0ABM5IJ51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133985.2">
        <property type="nucleotide sequence ID" value="XM_028278184.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278184.2">
        <property type="protein sequence ID" value="XP_028133985.2"/>
        <property type="gene ID" value="LOC114329165"/>
    </dbReference>
    <dbReference type="GeneID" id="114329165"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133985.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="444" mass="49838" checksum="A2862107FCBE2553" modified="2025-10-08" version="1">MGNSELFAGVATGCLLMVYAGMTEVSYQFQVYRFLNIKEISISLITKFIMSSKLGGLIGSLFFGALAEVIGRQRTITAIYLPLLISSIMFQATSDYVVGCGASFIAGLSIGGTYTVVPMFIGEISTKDMRGRLIGLMYPSQQLGVFIIIIGRIILSVFVETDMMPFKNYSSIILAMFGILLTGTAVRETPYYYLNKGKEGLAKESLTYIRSFAVNTELEYDEIQSGIKYIKSIETGAGIIFWSIKRSWIKPLLLMISVYIFTYAVYVFPYYAVRSISDSSWNPWVGRLVISIVPFMASFLILFVVDTVGRKWTLMLSFGGMILVLIVFLLFTIWKTYSANASFVLYILFLISSNVGAGPIRFVLLGEIFPLDKKGIYAGISTALLFILQLFVLEINQIKVLASETYYIDIYISLVILVIALIIVKFYYVETRKRTLNEIQIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKE4</accession>
    <name>A0ABM5IKE4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UHRF1-binding protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134845.2">
        <property type="nucleotide sequence ID" value="XM_028279044.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279044.2">
        <property type="protein sequence ID" value="XP_028134845.2"/>
        <property type="gene ID" value="LOC114329808"/>
    </dbReference>
    <dbReference type="GeneID" id="114329808"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134845.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1293" mass="146395" checksum="283D79A1D06EB2D3" modified="2025-10-08" version="1">MVSIIKNQLLKHLSRFTKNLSADKINLSTFKGEGELSNLELNEVVLMDLLELPSWLCLKQAWCNKVTFRIPWTKLKSVPICLNLEEVEIVVETCADLRIPSMQQGNSNAGVPGKYSFIHKVIDGITVHVNTVNILFTSPAFSASVQISRIVVDSKNHKFQPSDLRMTRLKNQAKGQVLIFKELKWDTVRIEAKSTKDKNLTPLRLIINEARCRIVIKKRLSDSFILGSRLAIILNDLMWFFTDSQLKAALYFIDSLTDLIQKSTQITRRTKAARKLEELPEYQAQLSQEESEVVDKYKLFSAHDVIETSYHLISHQIMLHLSDDEGAGRSSHPNLKNGDALHISLKKFHVDYYPYHLAKGNRKHWLKYNTSFVPHSLWQEQALNSFKTKLLNLIDQHKPLHTPLNRPMKNPGSTPQSPEQKSLPNSDPRNKKKIEAKIAKLMTSCIVLRIEDFTIYKVSSSQKKGLKEFIFGDRTQLSLPVDSNMVHAEFTYYYYPSDVPFPLPPPKFYVQLNPISVMFDVDTCLWINSFGLNLFQSLTSAKSEVPVSTYTYMDIKIEAILPRINFESPLEHPNQKDRPKCLSFQVTRATITNIRSLEQSSRADLAKCVDSFHMGSLFFGSEFPSQQNDFYVVTQKFIDHISTVDNIRNVPSQIDSSISDDWMANFSREMLWTDAKDVWCISLDPVWADFNGARAIGIAKSVPFLDALPVTIWLHTHMDPNSTVKPPGDCQENSQTDADIHALVYITNLVSVQINHYQYLFLLRLAEDAALLATYLAIDSERILKVESNSTIAMGVLIPQLEVTFVMPSNSPGKESSGGDIESVVPDTSSLADDIFIGSNPSVWHNSSLSITQIGISKKPIANGSSNQLDLPTSNSSDYLQTSPNRISSHEEHSFLLQQKGNLNLQTNINMGFTSLKKGFTSLKSSIDSALKASPDDLSDTMSIRSDASSDSEKFVHINCDLDIAGAEIIFIVVEFSERVEEASEVLEEDNTVTSTSEHSVTSTSRRKDLVSVSTFKLNKIEFVYQSLGFQSSLKIQLTNLMCDDCSCISWDELQSKFGTRSRVWTCNPPSDFTSPKVKLRLDHNLMVSKDSLSETDLTNRDSFAKLFSDLITIQVKDLMLNLNMSTVTGLADLVEDEVMPIPFPIKMTVDNVKVHLNEDRPPVNITSPGPIPIDLNVTHMYITRTEDGVFNLFPCSKSKTNSTNGQSSKKELAKVDSVSLNNEDLRRLMTFERISEENRLLRKTKEESDKEKDVLREYLKKSQDEVTRLLNEKQNLLDEIRRLQHHWNSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IP98</accession>
    <name>A0ABM5IP98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137934.2">
        <property type="nucleotide sequence ID" value="XM_028282133.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282133.2">
        <property type="protein sequence ID" value="XP_028137934.2"/>
        <property type="gene ID" value="LOC114332348"/>
    </dbReference>
    <dbReference type="GeneID" id="114332348"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="6">
        <location>
            <begin position="309"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137934.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="52622" checksum="CB553988A46F0C69" modified="2025-10-08" version="1">MISIRKGAAKRCRYGKCKNDTRYKSDNDDTYYFISFPKPCLEYRKKRIKISAEEHIKRCSKCTKCNLWVKNCGRKGFRSIDNVTKDTYICSLHFYGESGPTDMNPDPLIHQEVQEIDKSNGKVMKKYCGESGPTKMNPDRLSYQNVPEIIYIKVEMEEQNEPQKTDTNNIATIQQVSTAHKGVDIFDKKPSFIQEKMLPYQSSEMNTVSGDTNNEGINKSTRTIEIQTDSTRMCNKLLQVTTEKLQKNSALENFLISVRNDKKKCVFYTGFSFEQIQDLHRFLSPACENLNYVRIRKVNNGSPRNDKYKLTSMQQLLLVLLRLRMGYLIEDLAYQFDISVGLVSQICTIWINFLYFEFSTRLDPLILPSINIPETLPNDKTLPNMFQSVKNIKVTVTKFRLLQTILPVKKQNKLAITQQIVFVCSCLVNFQAPIVNTVNSHLSVGLSGNVVMDNENCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRF4</accession>
    <name>A0ABM5IRF4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like protein D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139619.2">
        <property type="nucleotide sequence ID" value="XM_028283818.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283818.2">
        <property type="protein sequence ID" value="XP_028139619.2"/>
        <property type="gene ID" value="LOC114333831"/>
    </dbReference>
    <dbReference type="GeneID" id="114333831"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139619.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="98953" checksum="63EBBFCF77626036" modified="2025-10-08" version="1">MKHEHFLRSKSNAKKHRPRECVSESSFLSDNFCSIILGKPGNNLMKKKILAVGEGDFHKILNNKNSSLHQQQVLLCDVEPVTNSKSFEINDKISPTKNDLRAVMDKNKIIKSNIDSNDVNKSTNYNQKILNRSSKIKKERKPRDLVEDSAKFQIGNKNENDTYKTDNNNNNKYSENARQKSVRDEVSYKSLISDLHPELLKTISETQNGDKGPDLSVRNAQTSQMIRLHSSKAEVFLPDQIIHSKQQFGNNKILSDADLNQYSGQDKSKKDSYESNSEEKTDIGKDRTEVTSTRLFRTQSPINDSLINTYESIAYDMSPKNNNLVDVVSEKEYQGQQIKTDSAYKQGLNLTADSRPCYCETHSQTSRPSILKPSQQRSLNSKVDQYPVKEASSMRSKIFVNKPSQTSNSHVTEDNHLTGNNVGTHKMPLVDTSVNTLEIESVGVQAPEQDITEISSTNSTESLTSEDIICYRPIHNFCGCHNREQIRKAEQRLDHEHILSAEYALPEKNKNVQIHNVAKLNNLRNYPINTVCNKIYHSNNNADRKRYILSSQEDYVTKEMPFSRNQPISKGIFKETPENVIYCENPIQNNGTRNNRSNSLEHRNFYNKNSSLSQNNRTRNTRKKYRYHNPVTSNAENARNDYCAGTCRCCARRGDIPVVPIPPPLEYDVSCSEDDLELIIEDQSDQFFDSDDSNSLPSRYNDLPYQNSDQYINLVQELEEKLQSRNKSRVQRTLQEFERRSRLNKPLEKPVINYEETSESEEPLIRAISELARKRNEDHKNFPCKGKACCTCILPAEKHEIEVKSNYSNNKPRIKTKSHWKQDGTNGTWYRTSKNLPEHVNVTANSVNKFSHNCGCSCTCGKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISX2</accession>
    <name>A0ABM5ISX2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140957.2">
        <property type="nucleotide sequence ID" value="XM_028285156.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285156.2">
        <property type="protein sequence ID" value="XP_028140957.2"/>
        <property type="gene ID" value="LOC114335006"/>
    </dbReference>
    <dbReference type="GeneID" id="114335006"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="157"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140957.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="304" mass="35710" checksum="0B2B86422EF6C6CC" modified="2025-10-08" version="1">MSLNDLLITDRRKIRKVWGKTESDVYKDIEILRKWLQTQKHLPEIPTDNMIEFFLVNCKFSIEKTKKTLDMYYTVPSLVPDVYKNAHPCTSDVESAYATVNIFCIPELTPTLHRLTIFQHKDVDFETADIRRSFAHCLKNFYEIRIHEDLSMGEIYLIDCERIKVGVLAKVTPMLLKQAAFILERVHSLRTHSVHVINAPSYYNQIVTLFKSLAKKKLADRVHVHKSLDELLKHLPLDILPSDFGGKQKSCDELAELWKKKMFEYKDRFDKLEKMQVNEVLRPEKLENDEILGYYGNFKKIDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IT44</accession>
    <name>A0ABM5IT44_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141128.2">
        <property type="nucleotide sequence ID" value="XM_028285327.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285327.2">
        <property type="protein sequence ID" value="XP_028141128.2"/>
        <property type="gene ID" value="LOC114335153"/>
    </dbReference>
    <dbReference type="GeneID" id="114335153"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141128.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="724" mass="85047" checksum="03D8187C79CBB4CA" modified="2025-10-08" version="1">MDVKVKIEHEEVDLPDLIDPQSLSEEHSVPKHEIHTHTCSECLEDFNCEFLLKVHQMIHDKTQYCFICKHKIHNKFKEHVMDRHFNQCDVCFKTFNYKKNLVQHMEHHTGNLNYIKCEKCDKRFRQRGSLISHMRSYHEGVKPYACKECDGTFTTSSSLDRHVKNVHNPNNPKHSKNVLTNVYDCDVCSTQFTNKTELQLHEKEHFESNKCKLCGKQYGGLNYLKLHTFLQHFKTERCTHCGKLFHKKTIEKHLRSHDKKKVITYCELCDQPFASNSILTRHLATHVTAQCKLCGMYNIKSMKNHLEAHRRGKVQKCSICAKFVSDIDVHNTNIHKNTEFLFCTVCPEKFTTIVERTAHNEEAHFEIIKCPKCKKQMGNSKLVDHVRKYHPELVYECDYCDQVLYGIATYNAHLESHKKVFKPYTCNKCLKSYENEANLKKHTCTALYYCHLCNKYYTSRHSYNSHMIQQHKPNIITATSTENLNALEIGGKKIYQCKKCFLTMFKLNRPHHCHHLSAILVRRIHHKCNLCGFLGATMGGMRRHCFKYHENETDWVTIKAAKGSNKKPQMRRNFIYKCHCGNAFQYESSLIKHRSKCLLVKPLKCSICDCGCSTKRNLLRHKQRNHVPRVVEEPSEEKNLSNAKSHQLKRRAVPSATVVTYRQRKKALKCKLCDYACFSSKFMGHHRRTYHDSDNLYLEDLNYKPEVENYLYEDHTQDITLDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZ67</accession>
    <name>A0ABM5IZ67_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151293.2">
        <property type="nucleotide sequence ID" value="XM_028295492.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295492.2">
        <property type="protein sequence ID" value="XP_028151293.2"/>
        <property type="gene ID" value="LOC114344662"/>
    </dbReference>
    <dbReference type="GeneID" id="114344662"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151293.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="643" mass="72592" checksum="1190D314F8C2B5C7" modified="2025-10-08" version="1">MKRSQQVTVTETTPGYSVEKMYYKEYKYETVFSTSQLSKLENFVLPPRTTILALSQNGGDKEEDKKYVVKNHGKADLFVEVIHLNNQDDAPQWFVVQPDQTTEIDIEDNLEQSVLKVSNNSYEQEVSFSAKGGHVIDDLENNMEELLDSNETETEMVVLENFSLSPRTAVTVLSQNVEGSNEHPGKYTVTNLGKAAFDIELKRTSPVQTLELHRKTVQPNTSESFELTAQFQSTVLEVINTSQTEDAVFRAEGGDVIEDIEDLIRNIDEKEETGVTNILTNLESLHLNSRSSVPALMYDPKDDTISEHHNFTVTNHGKSDIEVEVTYTDSDDRANDQYKVVKPNETVKLEHKKDAGVALLNILNRHYTDAAIITAKGGRVVRDIERKIKQLVSDEKSIMMVNDFHLAPASSVVVMHQVGRYNRRPVYPAGHRKLQHVVVRRLKHHPGLTSGRFARKPAVSRPRKQSGSPAGLGRRPFRRPSCRPMIRPAHLSGQGGQHPAQQEHHQAQQQHHQAQQQHQQGPQARQCRPARRPRIVMRPAAQRKPVAHDRYTVANHGTHAFTAQIVHVKGGKQEIVRSQVVQPNETEELLLKDVNGSSLKIVNENETDYAIFSAEGGEVVDGLRYMVRPLRRCPGARKMFYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLC3</accession>
    <name>A0ABM5JLC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498741.1">
        <property type="nucleotide sequence ID" value="XM_050642784.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642784.1">
        <property type="protein sequence ID" value="XP_050498741.1"/>
        <property type="gene ID" value="LOC126879614"/>
    </dbReference>
    <dbReference type="GeneID" id="126879614"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="352" mass="39969" checksum="2ABB9F5773381736" modified="2025-10-08" version="1">MKPETDYAEKINEISKQFLCVYPLNNFNWQNIFNIFLLEDVQELLLNKTVNSELVLKYPIQIKYQKLFLKYILDKLESLQAASEIDLEESTIHDDLYSAYGRLVAAGDSVEKNYKHYSLGKEYKVITLKESNSLISDGTTGLRTWQASLALSEWIIQNSNSFKQQTVLELGSGVGLTGLVLNNVCQTKTIYLTDCHEAVLKTLCENVKLNVNGSHLDTTDDIESHNDCSGLKNCCVYSNTDTSTISILNLPWENVTPSICKDLGVIEKVIAADIIYDNDLFQSLINAMKCLKEYCGVEEFIFACTERNSETLEEFLMLTKTVCPRIVELPVPLQSKFLWPTDTPVKIFQFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPA2</accession>
    <name>A0ABM5JPA2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">uS12 prolyl 3-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499772.1">
        <property type="nucleotide sequence ID" value="XM_050643815.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643815.1">
        <property type="protein sequence ID" value="XP_050499772.1"/>
        <property type="gene ID" value="LOC114331051"/>
    </dbReference>
    <dbReference type="GeneID" id="114331051"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="539" mass="62740" checksum="096F7B0ED3536667" modified="2025-10-08" version="1">MTSKENHKYDEDSDNDYTSEESSPDDANYFEESSGTEPETECELWDHDCKVIPNTPSSLIGYHLMPTCSRDPDTIPQKKLKISAEIHKNLVRADFFNDLKDHWSKDEKLSSPDVEIITEPFKVCVINKFINNEDVLDNVRQEFNELDWNMRNMDLYEFFQSKDLKYLSSDYINAIFNFLKGEAMEWVANLTGYSLTHISATCSLYSNTDYLLVHDDQREDRMVAFVLYLTGKNGWNESKGGALQLFNKSETDQPQVCVRNIFPANNQLVLFPVTSDSYHQVAEVTTIDDCRLSINGWFHVKIPPVFKAPIYHPLNDGLYSKNSIKAKEVDIDLVSWLSEDYLNSKSIKIIKKHIQENSEISLRKFFRSECFNEISRTLDSSDTQWISFGPPNRYCYEKIDMNNLPHVLERFLDLFQSSAMFSLLEQYTDLELSRPNASMKFELQRWTCGNYTLLSDFDWDETIELDLIVYFGCEKSSDVIGARTQYVTIEDEIQNALITLEPEENNLNVVYRDTARFTKYFSKQSKCKKFYTLVCSYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPD5</accession>
    <name>A0ABM5JPD5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_050499794.1">
        <property type="nucleotide sequence ID" value="XM_050643837.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643837.1">
        <property type="protein sequence ID" value="XP_050499794.1"/>
        <property type="gene ID" value="LOC114331815"/>
    </dbReference>
    <dbReference type="GeneID" id="114331815"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="75"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="334" mass="38938" checksum="FA1C5C481CBA430F" modified="2025-10-08" version="1">MTILVQHIFCKTFISLTGIIVCTIIIFNVITNITPTATEQSYTERFISNETQVQPDIQPKSIEENEVSFCKDVASSQFVGRVLVLRSPSTIKEMEHQFDWLQAGGHWHPPNCRAKQKLAVIVPFRNREIHLSVFLRHMHPFLRQQQLDYTIFVIEQQGDKPFNRGMLMNIGFEQAMSMDQFDCFIFHDVDLLPENNRNLYMCGSVPRHMSVAVDVLRYRLPYKNIFGGVTALTTQHFSLVNGFSNSFWGWGGEDDDIFNRLQAHKLDVTRYSSVIARYKMLRHQKAKPNPQRYNLLKEGKKKYTIDGLNSLHYKVLQKQKKMLYTWILVDINTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPZ9</accession>
    <name>A0ABM5JPZ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Targeting protein for Xklp2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPX2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500014.1">
        <property type="nucleotide sequence ID" value="XM_050644057.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644057.1">
        <property type="protein sequence ID" value="XP_050500014.1"/>
        <property type="gene ID" value="LOC114330701"/>
    </dbReference>
    <dbReference type="GeneID" id="114330701"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF44">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 central" evidence="10">
        <location>
            <begin position="185"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="TPX2 C-terminal" evidence="9">
        <location>
            <begin position="445"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="463"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62969" checksum="571872BB0064EF7B" modified="2025-10-08" version="1">MAESFDFINAPQFIDFNKDMDYSRGTFDAYFDQYQDPLNNSDILSEVTLIADDLESLTTSKSKFRKSMSVGDLQKLCDNIHKLRSGKIYINEESNQESTEETFAEVKYVSSNSLCDDTSCSTTSSSNRRTTKEFINRLAQPKRQFKSDQNLNKDEYVPMAEALKKFQNATPKRFRTRVNSSHEPLKCTIPQSPKLQTTVRSRPVHVLSYEEQQRMAAEEAKKTQFKAHPVNKKALQPPTPPVSKGKRSTIPEPFKLTSVAPKKIGESPKKTQPAFHAKPVPRSLYENNVPKINHSLMRTQVTKPCTPSFMKKYNANPIKAIPNMNESILQQPNAKLRATKPLPFSFELRDQHTKSRRDELMRKCIEAEQKAREFHAKPVPKSVLVQSKKFNTSGSSRCSLLMTTKTNSQDNLKTTQFKAKPPTVLYKKPFEPKRSDKPMIEMAEFNLHTDVRAKEREHFEHYIKDKENKLVEIKQREEMMRKQEEEEEIMRARKEAEFKAQEIRRYKELNIIPVKEVTEPVSPKFLTNKLKNNSANKENTMSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQQ5</accession>
    <name>A0ABM5JQQ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="3">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050500270.1">
        <property type="nucleotide sequence ID" value="XM_050644313.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644313.1">
        <property type="protein sequence ID" value="XP_050500270.1"/>
        <property type="gene ID" value="LOC126880450"/>
    </dbReference>
    <dbReference type="GeneID" id="126880450"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047318342" description="GDP-fucose protein O-fucosyltransferase 2" evidence="13">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="429" mass="50255" checksum="F1B9E5CDF245C6DE" modified="2025-10-08" version="1">MNTLSGHKLHWDCVTIVLIISCIVSIHSTNSEDFCFKNEENCSLSSKRYLLYDVNRPEGFNLRRDVYMRLAVLAHKMRQSSNSELNSFSLVLPPWSHLIHWTYTEYPEQIPWGLYFDLESLKKFAPVIEMYEFFDIYPNKYSKVVIDEVYNLQHFEDMFETGNFEERMKIEKCQRTYDNTYLFYKNITAKDVKCLSYHGPATKLTELFVNTSAEIILLNHAEVTLHDFFGSKLYWQARRSMRFSKELKLIANEFRKTVLNSTDASDNTPLPEFWTDEKPKRNAIGGPYVSIHLRRRDFVRNRPNEAPSLQTAADQIKQVLKNLDLKTVFVATDGTQEEFNNLSSFLQEYNVVKYRAPSQIEKKYKDGGLAIIDQIICSYARYFIGTHESTFSFRIQEEREILGFPVDTTYNVFCTSSGCQKPSVWEIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS51</accession>
    <name>A0ABM5JS51_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500767.1">
        <property type="nucleotide sequence ID" value="XM_050644810.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644810.1">
        <property type="protein sequence ID" value="XP_050500767.1"/>
        <property type="gene ID" value="LOC126880759"/>
    </dbReference>
    <dbReference type="GeneID" id="126880759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="678" mass="77394" checksum="B9E801F233E4CE3E" modified="2025-10-08" version="1">MAPQKNGRVYDSEVKCCKKCYKVAQSGLLCANCGTLSHSGCLKQLKSIKYIDDETVICCEESVRLSDPPNKTLDSEADDEDPRQTEISDGPKTMARRLLCKQVFYEASNTYSNKMKDEETTVNPPSNFQNNLIQQGTVSMFHVNLQCISNKVDMINAFLADKKFYDVICFSEHWQTEENLKLINISGFSLANFFCRVEKKQGGVAIYVKENLMYSSLNLNEYNVEQTSEFCAIYIPSMRTNVLTVYRSGNGDCDLFLVNFENVIAFLLNKADKLIILGDFNINFKIKSDSSYDIQNLLMSFGLEITINDYTRITSQSSSCIDNIMTNFSENIYRVGVFEPCFSDHRAQFISIDSDLKVVDTNQSLQRSITSSGLQKLKYALASTKMDFFYDTNNDPDVLMFFLTETYNNLILKFFPLKKVRQTAKITPVQWFNDELRSYRSNLSLIKHIADVTKDPDIFKLYKQQKYEYNRQLQNAKKSAYSGFITNSNNKPRDCWKILNFERGNTRSSSVQPDLSPDEINQFFITIAENIITSLPTINNDILFSYRNYPSPSKSFCFRPVVEDEISQIIKSLNNSNCKDVHEINSKILKETYQIVLTPFTHLINLILSTGVFPEALKYSKMENFSESLFGGKYAVPRIMVSLPLIMATNSCSISSEDGKCLLFNCLDTAIRTPPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT07</accession>
    <name>A0ABM5JT07_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501065.1">
        <property type="nucleotide sequence ID" value="XM_050645108.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645108.1">
        <property type="protein sequence ID" value="XP_050501065.1"/>
        <property type="gene ID" value="LOC126881074"/>
    </dbReference>
    <dbReference type="GeneID" id="126881074"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046725335" evidence="1">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="173" mass="16384" checksum="EC17CBBC03E64171" modified="2025-10-08" version="1">MLFPRYAFLAFLGALVFAVLAAYSQAGVYGGGYGGGYGYGGGGYGGGYPGGYGGGYPGGYGGGYGGYGGYGGGIGGGIGGGVGIVKIISAGPPPLPLPPPPPPPPPPVKIIKIVNGGGYGGGYGVGGGYGYGGGYGGGIGYGGGVGYVAPPPPAFKVVRVVTTSGGGWNPGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT70</accession>
    <name>A0ABM5JT70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050501136.1">
        <property type="nucleotide sequence ID" value="XM_050645179.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645179.1">
        <property type="protein sequence ID" value="XP_050501136.1"/>
        <property type="gene ID" value="LOC126881123"/>
    </dbReference>
    <dbReference type="GeneID" id="126881123"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="199"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="692" mass="80023" checksum="27BF7C21DEDA4986" modified="2025-10-08" version="1">MGGKYTKLDPMEVEVPEIDALLNRDGYLRPYEREIRRRYACFKDIEENIEQNGGGLDKFTQGYKYYGINVQQDNTIICREWAPGAQQLFLTGDFNGWNRDSHPYKKLEYGKWELILPPNQDGSPAIPHLSELKVVVQTWEGHKVDRLSPYATYAVEPPKHEGTIYKQKFWNPPQTQRYIFRHKKVPRPKSLRIYECHVGIATQEPKVGTYDNFTDNVLPRIVKQGYNCIQLMAVMEHAYYASFGYQVTSFYAASSRYGTPEELKRLVDRAHELGLMVLLDLVHSHASKNVMDGLNQFDGTDSCFFHSGPRGEHSLWDSRLFNYSEFEVLRFLLSNIRWWMEEYRFDGFRFDGVTSMLYHSRGIGQGFGGHYDDYFSMGVDTEGLVYLMMANHMIHKLHSDAVTIAEDVSGMPGTCRPVTEGCMGFDYRLAMAIPDKWIKLLKHKSDDEWDMGNLIHTLTNRRWMEGNVAYAESHDQALVGDKTIAFWLMDKEMYTHMSTLSDQSLIIDRGIALHKLIRYVTHGLGGEAYLNFIGNEFGHPEWLDFPRAGNNSSYHYARRQWNLVDDDILKYKFLNNWDAAMNHTEQKYGWLAAHPAYVSTKHQDDKVIVFERAGLVFVFNFHPTKSFADYRVGVEVEGNYRIVLSSDDKAFGGFDRIDKSVTFATTPEGFAGRRNYMQVYIPSRTCITLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTT3</accession>
    <name>A0ABM5JTT3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501350.1">
        <property type="nucleotide sequence ID" value="XM_050645393.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645393.1">
        <property type="protein sequence ID" value="XP_050501350.1"/>
        <property type="gene ID" value="LOC126881241"/>
    </dbReference>
    <dbReference type="GeneID" id="126881241"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="182" mass="21065" checksum="51FBFB70E6EBF0F2" modified="2025-10-08" version="1">MQKHNCQNIQQTFFTLPKEPKRRLKWLKACRRDKKDISQKSIGLYVCEDHFDLEQDMDNYIKFKIMGGPKIIKSGVVPHIFDCQPDRKRAFSQPVREAALKRVKRQLLEDAASTSKSVLEDNDDKRQCDPSFTNLVQSGPELNQSALPQKLNHVSTQTHIKIRSKGIQCKFQRSRVVAIENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTW7</accession>
    <name>A0ABM5JTW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050501380.1">
        <property type="nucleotide sequence ID" value="XM_050645423.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645423.1">
        <property type="protein sequence ID" value="XP_050501380.1"/>
        <property type="gene ID" value="LOC126881258"/>
    </dbReference>
    <dbReference type="GeneID" id="126881258"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="325"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="553" mass="64230" checksum="ECC23A0B32FC8908" modified="2025-10-08" version="1">MNVDIDKSSVVQWFDGQEKHRCGYCKHSDTSITHGMWAESLTVDDYQNLIDRGWRRSGKYCYKSIMDQTCCPLYTIRCDVVNFNISKSQKKNIKKINKYLKDGIINKETTEAVDSIESESHLHIPKDHPAFDLTNINTNNVDNVLSGYSNDNQKPSTSKKEVHKKDKCERLERPIDQSCDTENTSSQKLITKTLCKEGLGADPNKPPCKKAKLLRIERKKAKGASVQKNSTPVQRKTLEEFLEEISVDNKNKLRMCLIPTSVPNASWTEVEDIEFELYKKYQMSIHNDPPSKLSLHGFKRFLVKSPLKITVERMSTTNDTFNFSANLYRKYQIKIHQDTPEECDEEQFFHFLVESPLQPKSFPNNEEGPGYGSFHQQYWLNEKLIAVGVIDILPKGVSSVYFFYDPDYACLTLGTYGSLREVELTRKIQKSLPEFSYYYMGFYIHSCPKMRYKGKLTPSYLGCPETYTWIPIEKCLNLLEANKYSRLNEDIDALDTNIPSEEDILHIKIIYKRTLLYFSDFKNFVEDPERFRKIGDLIGKKCCNTLIFYENSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU74</accession>
    <name>A0ABM5JU74_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501492.1">
        <property type="nucleotide sequence ID" value="XM_050645535.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645535.1">
        <property type="protein sequence ID" value="XP_050501492.1"/>
        <property type="gene ID" value="LOC114331017"/>
    </dbReference>
    <dbReference type="GeneID" id="114331017"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="360" mass="41253" checksum="CAF27EDE9F3DD30A" modified="2025-10-08" version="1">MFPETEGFILAIQDQIIPTRNYLKYIVKDPQSKRTNADMDVKTKNPSNILPGAARRLSELSIKNAMTQEFQSSRGFGLDRKNVAGIGGIKPKTLEERKIYTIKEHIKDKVKELEDNKAEFASTLAARESQIQEVSTTLTNKAQEIENLKKEIGALVEKYELSNKEVVASHTQEITARHEKIRHLESEILQKDQNIKFHVDASNEHQENLNRKDLDLIKIRSELEESQKTSSVMIASLKNQIEGLQNDNKQQQSRNNELQTELQNREQLNVTINTEIGKAAENLAVLVEQVKQKDDLIESLRSDVTSREIELENVLATNLKALSEKNEAERRIRAEKERLCMTIGLKNEELEELQKRLTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUS3</accession>
    <name>A0ABM5JUS3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501679.1">
        <property type="nucleotide sequence ID" value="XM_050645722.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645722.1">
        <property type="protein sequence ID" value="XP_050501679.1"/>
        <property type="gene ID" value="LOC126881438"/>
    </dbReference>
    <dbReference type="GeneID" id="126881438"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="658" mass="77215" checksum="C879BEA301CFCE7B" modified="2025-10-08" version="1">MELTQEVSVKTYKIEIDNNQVCDDPLSTFKIEIKEEPKREHTYDAFDYSEFNQLAENTELEQDEYKFNLFEENQTKNDEGCPKEENKMETLPAHSSREENYRGQHVKEKILNKNVEVVTGQRAHKCEICLKQFTKSDSLKQHLRVHTGEKPHKCEICVKQFSQAGDLKRHLRAHTGEKPHKCEICLKQFSQKGILKNHLRTHTGEKPHQCEICCKQFSQKSILKIHLRAHTGEKPHQCEICFKQFSQIGILKNHLRTHTGEKPHQCGICVKQFSQESDLKRHLRTHTGEKPHKCEICSKQCTQAAGLKKHLRTHTGEKPHECKTCFKQFSEASNLKRHLRVHTGEQPYKCETCLKRFTTASELKRHLRVHTGEKPYKCEICFKQFGVANTLKTHLRVHTGETPYKCEICFKQFSQKVQLKIHLRVHTGEMPYKCEICFKQFRRTGNLKAHLSLHTGEKPCKCDICFKQFSNLTNLKTHLRVHTGEKPHKCEICSKQCSQANDLKKHFLRMHIREKLHKCEICFKQFITKSELKSHLRTHTGEKPHECEACFKQFSNASNFKIHLRVHTGEQPYKCETCLKRFTTTSDLKKHLRVHTGEKPHKCEICLKQCSQAGDLKKHFFRMHIREKLHKCEICFKQLITKSDLKSHLRTHTREKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVJ5</accession>
    <name>A0ABM5JVJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELYS beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501961.1">
        <property type="nucleotide sequence ID" value="XM_050646004.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646004.1">
        <property type="protein sequence ID" value="XP_050501961.1"/>
        <property type="gene ID" value="LOC126881629"/>
    </dbReference>
    <dbReference type="GeneID" id="126881629"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="1">
        <location>
            <begin position="43"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS beta-propeller" evidence="1">
        <location>
            <begin position="249"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="45837" checksum="2C3CA5D195583F5D" modified="2025-10-08" version="1">MSLDVKQILNFPQGCIEYIPQFENETMSSNDLDILGGILHDTRHVWHAKGPTLEVRNTKTGSKVGAWVFGGILKDSNTTITCVEEIPRPNGRISLLAVGIDCTISGGIICIFDIFSSKVLRAIQVKDKISYLHVIDPGIKDLNLSGPLRNFDGILAVGLDGGDVIIVDVCRQICEEPLHSISKRDELNPSQLFILTLRHIPKVEQYKEGCVRDGNHLAIHLNAVFNSTTEHFVLKGPKGDDRIHVNRAEVVTSALHYCSQLTSLLVGYNFGAFQLWDLTTLKLVYTSPICEEHIPITRFALQEPTDDPRAFCYVWVAFGNSELYQTGLPYAVMYSLCYETKEYQEGYGYVYQDFHYCTIRFQIQLGQLEENRWGICKQTSEVNISNSADLLGPPITSNLSKQFRKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWJ4</accession>
    <name>A0ABM5JWJ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-N-methyl-L-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050502309.1">
        <property type="nucleotide sequence ID" value="XM_050646352.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646352.1">
        <property type="protein sequence ID" value="XP_050502309.1"/>
        <property type="gene ID" value="LOC114328757"/>
    </dbReference>
    <dbReference type="GeneID" id="114328757"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19186">
        <property type="entry name" value="SET_Suv4-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044426">
        <property type="entry name" value="Suv4-20_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="117"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="760" mass="87115" checksum="8975FD837C0BAA0F" modified="2025-10-08" version="1">MVVDVSVRPLKMQPTGMNPKELSDNDDTATSLVLDPHLGFTTHKMNVRFRAPRANNTELKNIVEEFIKNQNYEKAFAKISRGDWWPRIKSKMQQKKLEDHIYRYLRVFDKDSGFVIEPCYRYSLEGQKGAKISATRKWYKNEKIERLVGCIAELTEEEEKQLLHPGKNDFSVMYSCRKNCAQLWLGPAAYINHDCRANCKFVATGRDTACVKVLRDIEAGEEITCFYGEDFFGDKNCYCECETCERRNTGAFAKETDQQEENGYKLRETDNRINRTKVKVQGSKIVNCHEQFSPDNGKIISPLSMKELRQKGLTKYDAELLIAQGCKFSDIAEFNRKRDVHTNTNKQIKKCSTNSSKNKKSVIQDTINATNTRESRMQRRQARQANLELMQSAPRTISRSNLLDDLQSNASSCPSTFSDTEPACDAGSQQDKFNDSHESGNGINPIDMDEKGAVMEGITLRNHKRLSDPVPDIIPCTPSEDLHPIIHPQTQVDCNQNGMPNVNHITHDTKLLTDVELETNVELETEIKVMSEIKDDKVISKDTSEYQESSSDNFNITIKRRNSNRPSTPIEEAKCDEKSDIYEFNDDEDITDEAVLLRKSKIVQDSSENHTHMREKSEQMHTAVETSNWINREIRESPPKCVQVPVEQKTPEKCGGRLKLTLRMKRSPVLDEVIESGNSLSEDYFEPEYEVLRVEGVDNIACTPFSHRKKRHKAKERRREKRHRLAEAALPQLPMKRLKLKFGNESHTIDIPSTSTNCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWZ6</accession>
    <name>A0ABM5JWZ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502461.1">
        <property type="nucleotide sequence ID" value="XM_050646504.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646504.1">
        <property type="protein sequence ID" value="XP_050502461.1"/>
        <property type="gene ID" value="LOC126881864"/>
    </dbReference>
    <dbReference type="GeneID" id="126881864"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="87"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="432" mass="47798" checksum="ED4A7D58DBEB9261" modified="2025-10-08" version="1">MTWGFVTCGPNEALVISGCCYSKPLLVPGGRAFVWPSIQKIQRISLNTMTLIVDSPTVYTSQGVPISVTGIAQVKIQGQNEEMLLAACEQFLGKKQDEIQLIALHTLEGHQRAIMGSMTVEEIYKDRKKFSKQVFEVASSDLVNMGITVVSYTLKDIRDEEDPVDGRGYLKSLGMARTAEVKRDARIGEAEARAEATIKEAIAEEQRMASVFLNDTEIAKAKRDFELKKAAYDVEVQTKNAEAEMAYELQAAKTKQRIKEEQMQIQVVERTQQIAVQEQEIARRERELESTIRRPAEAEKFRLEKIAEANHKRVLLEAEAEAESTRLRGEAEAFAIQAKAAAEAEQMAKKAEAWKEYKEAAMIDMYLDVLPKVAAEVAAPLSQAKKITMVSTGTGEVGAAKLTGEILDIVNKVPMLVKSMTGVDISKSVHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXD9</accession>
    <name>A0ABM5JXD9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502607.1">
        <property type="nucleotide sequence ID" value="XM_050646650.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646650.1">
        <property type="protein sequence ID" value="XP_050502607.1"/>
        <property type="gene ID" value="LOC126881916"/>
    </dbReference>
    <dbReference type="GeneID" id="126881916"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="318" mass="36354" checksum="50DA9B19DD3140A9" modified="2025-10-08" version="1">MWTIPPLELNHFRTNFDNKDDWKGDLQFKKLYEVWAEFKNEALLVTNKHKHVTGEDDSNLMEGNEEMSISFSVPTASTSTPNGKHREESVILPNEEQSQNGNSTILQDKSTTSLNVSESFLSPDKLENVALYKDKEDQGYVVSTPFKKCLIFPKTHEKEPPKRKRKIFPAGVSTTLYRAHYDNITSKSGPSKQSQIKIKKPAVKRKVISESESSADDVPYCDEDLDASDVENYTIKNIHDGDFVIIKYNGNLYPGKVIKANQEGAEVSSMEKAGYDWKWPEKEDVLFYFYEDIKKIIKEPLVKGKRGYYSVPELSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY90</accession>
    <name>A0ABM5JY90_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502907.1">
        <property type="nucleotide sequence ID" value="XM_050646950.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646950.1">
        <property type="protein sequence ID" value="XP_050502907.1"/>
        <property type="gene ID" value="LOC126882102"/>
    </dbReference>
    <dbReference type="GeneID" id="126882102"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04010">
        <property type="entry name" value="C2B_RasA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01244">
        <property type="entry name" value="PH_GAP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05128">
        <property type="entry name" value="RasGAP_GAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF148">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="124"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="9">
        <location>
            <begin position="336"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="585"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="96620" checksum="3683BB1EB9AC60AD" modified="2025-10-08" version="1">MADEFKVRLEERLKIKIGEAKNLPARLHGSATQRDVYCTLSLDQEEIFRTGTVTQSLSPFFGEEFQFEVPRNFRFISIYVLDRDRHLKQDKMLGKVAIRREQLSSYNNKDHWFPIKAVDADSEVQGKVNIEIKFDTEANVYKRRLLVQVVRCLELTLKNGSCDPYALVCVSYTNGKSISKRTKVRKKTTSPQFDEVFPFSNFDGGKDSMCEGDAEICELHVSMWHDTPGIGDDVFLGEVKVQLRGMQQQNSAHRNAWYYLQPRSTKNRPFLTNSTPPGTRLSSDNSLGSLRLQIQYTEDRVFPASVYEDLKNLLLESTNIQPITATPVYVLGEIINKMDIAQPLVRIFLHYDKIVPMIKALANVEISNVTDPTTIFRGNTLVSKMMDEAMRLIGLQYLHKTLRPTLELIFNERKPCEIDQTRVRDATTVATNLANLKCYIQKIFEAITQSAVHCPALMCQIFYNLKECAMKHFPENKGVRYSVISGFIFLRFFAPAILGPKLFDLTTQTVDCQTNRTLTLISKTIQSLGNLVSCRSTQQVCKEEYMEGLYKEFYTETHMTAVRQFLEIISANTSSQQVIENDMPVMLKEGLMIKRAQGRKRFGRKNFKQRYFKLTTHDLSYSKSRGKDALCRIPLTNILAVERLAETSFKMKNMFQIVQPERALYVQAANCVEEKEWVDLLTKICQTNANRLKKYHPSAFINSQWLCCKSPNELAPGCSEVSRTDSNYRMNLDPERDLQRVHSLVINHLDTLETLCIDLCSSKVHGEGVTAEAAILCDILNRLREVAYQIEQKHRIYKRTMDRNTKYGSLAAPIGDDNYLLASRLNVDASILRRCVSSEPTSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ88</accession>
    <name>A0ABM5JZ88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B3/B4 tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503250.1">
        <property type="nucleotide sequence ID" value="XM_050647293.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647293.1">
        <property type="protein sequence ID" value="XP_050503250.1"/>
        <property type="gene ID" value="LOC114328687"/>
    </dbReference>
    <dbReference type="GeneID" id="114328687"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="4">
        <location>
            <begin position="295"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="512" mass="57830" checksum="6127B02DBF8F9368" modified="2025-10-08" version="1">MWPEIEQAKIENRHELVLSGKEIASKIAKNGLDLSVFTLEGLNFLNISGTELSAIPDDIGKLANLQTLVLHSNKLEHANENIAKLTKLKMLDLSRNLITSIPDGFADLPLTTLNLNVNRLESFPEFTKNSKLAVLDLSNNKLKLFPRVCSEELVNLSELKLHGNEIEEIPNNIHVLPLLKLLDISENKIKTLPGELAECHKLKDLNLKSNPVSDRRLLKLIDQCRTKQVLDYVKQNCPKTTNGDVANKGKSKKKNKSKNDDEEDDNSVADYKYSINVKSHNNNFKVIIKNGVKTVREHFAACVVNNVSFTEESFKKFIQLQNKLHDSVCEKRNVATIATHDFNKLPPGDLIYSTSQPSELMIKPLNRATVMSGAELFTKLQTEANNLRKEKKRSTYSGIHKFLYLIEGKPQYPCVINANKEVISFPPITNSDISKIEVTTTRMFIEVTSSLSPHSCKNVLNTLLKDMVLLFEKDLEVEQVKTVDEQEQLKVVYPSKTDLVFEKSVSIKTNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ92</accession>
    <name>A0ABM5JZ92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503255.1">
        <property type="nucleotide sequence ID" value="XM_050647298.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647298.1">
        <property type="protein sequence ID" value="XP_050503255.1"/>
        <property type="gene ID" value="LOC126882387"/>
    </dbReference>
    <dbReference type="GeneID" id="126882387"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978819" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="141" mass="16200" checksum="F1AFAA152CF5D9D0" modified="2025-10-08" version="1">MFRLLPMIAASCFQLTALPVEMWSNILRLLDPLSLLATARSDPRFKSICFGDSVLRNNLREALEIERRQAEEIIRNPAKSITISREDAKRVFSANVSKKITKKSVNLRHCLEVLKKKPMKAENKKKNQCLSTVKKVFNCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZU6</accession>
    <name>A0ABM5JZU6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 13B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503461.1">
        <property type="nucleotide sequence ID" value="XM_050647504.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647504.1">
        <property type="protein sequence ID" value="XP_050503461.1"/>
        <property type="gene ID" value="LOC114328156"/>
    </dbReference>
    <dbReference type="GeneID" id="114328156"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051995">
        <property type="entry name" value="Ciliary_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47325" checksum="6470920413D6F5E6" modified="2025-10-08" version="1">MTKRALGREHWSRYNTRKLTLLLVGLDNAGKTKAANGLVGDRLNSPVPTVGFSVVNLKYSDYSVKIFDLGGGPNIRGIWHQYFVDAHGLIFVIDSSDVSRFGEVKMVLEDILYSDKIAGKPLLILANKQDSVNAVDEIEIIEFLDLEFLVNNRKCPTLVQSCAASESNANKLDIGVQKGYNWLMNYIDKHYDSLNQRVEQDVEEQEIKDKQELLEKIKRIRNLHALEQSKQNEDTIETYSDYVKKINGEIKSIQDDIAPSTSVITLEDTNTGPDSDESSISFPPIYINAETERNERPKSAVELVKHQLQLKDSFKKPNVRPRSNKTAPIHLYGTRTPHSARERRRETLFDRRNLKSADNVLSTISGMFSSDVNVVNSRGDHNSIGLNHFGPKVHSLDNSGVPFVHRPNREGDGLSIVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1B1</accession>
    <name>A0ABM5K1B1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503978.1">
        <property type="nucleotide sequence ID" value="XM_050648021.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648021.1">
        <property type="protein sequence ID" value="XP_050503978.1"/>
        <property type="gene ID" value="LOC126882944"/>
    </dbReference>
    <dbReference type="GeneID" id="126882944"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF10">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58532" checksum="246EE5059AE64C03" modified="2025-10-08" version="1">MAKNTSNYKLSAAIANLKYNDLIPYPNANDKVTHEFLQKIVDVLLDYVKQQNDRKEKILDFHHPEEMIKLLDLKIPEEGVSLGQLVNDCATTLKYQVKTGHPHFFNQLSTGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVMTHMREVIGKSWRKGDSILAPGGSISNLYAFLAARHKMFPNYKEKGIATIQGQLVMFTSDQSHYSVKSCASVCGLGTDNCVMVPSDEHGRMIPQELERLVVERKNKGHIPFFVACTAGTTVLGAFDPINELADICNKYGMWLHVDAAWGGGLLLSRKYRHPRLSGIERADSVTWNPHKLMGALLQCSTIHFKEDGLLMSCNQMAADYLFMQDKLYDIRYDTGDKVIQCGRHNDIFKLWLQWRAKGDEGFEKLIDRLMELTEYMVKRIREQPDKFYLIMEPELVNVCFWYIPKRLRNEPHGPAREKKLGEMCPKLKAKMMEEGTLMTGYQPDDRRPNFYRNIISSAAVTESDIDFLLAEMDRLGQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1L8</accession>
    <name>A0ABM5K1L8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504085.1">
        <property type="nucleotide sequence ID" value="XM_050648128.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648128.1">
        <property type="protein sequence ID" value="XP_050504085.1"/>
        <property type="gene ID" value="LOC114333529"/>
    </dbReference>
    <dbReference type="GeneID" id="114333529"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="189" mass="21108" checksum="96A596C6848E9653" modified="2025-10-08" version="1">MNKIACVTFGDESVGLRSLLITYTTNAFPAEYVPTVWDNGEYETTLDGKDVSLSLISMAGQQEYSRLRPLAYEMADIFLLGFSIGSPSSLTSLQIVWVPEIRKLCPNTPIVIVGLKKDLRDNPDTVKLLKQKNLKPIPFSYGVKMAQQLGAAKYIECSALKQEGVKEVFEEVIRAFRAHQSRKNKCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6P5</accession>
    <name>A0ABM5K6P5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505860.1">
        <property type="nucleotide sequence ID" value="XM_050649903.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649903.1">
        <property type="protein sequence ID" value="XP_050505860.1"/>
        <property type="gene ID" value="LOC126884105"/>
    </dbReference>
    <dbReference type="GeneID" id="126884105"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30682" checksum="F5D094D40E65917C" modified="2025-10-08" version="1">MDDKIEMLIGLIRGYPHLYDKSNRNFKDQHMKENSWKKIAEGVEMTVKDCQRLWLNLRNKYGREKKALPSGSGAPATPQWEYFDSMSFINKYVKPRHTHTRTAEIARTVNECTQPLKSPVFESSCSSNAWANSTIIESNADFQTQGDDMSESDQANETQDEEMYEENIVIQMEEAEDTEEVRHPVHAETAKVADKGKKKKTINGPDTAEVIDAAKAISQHLKNLVGQAKQPKTPSDILGEYIASVLKEMPPEKQKRKRNRLLEVLLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6W3</accession>
    <name>A0ABM5K6W3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505926.1">
        <property type="nucleotide sequence ID" value="XM_050649969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649969.1">
        <property type="protein sequence ID" value="XP_050505926.1"/>
        <property type="gene ID" value="LOC126884124"/>
    </dbReference>
    <dbReference type="GeneID" id="126884124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="107" mass="12871" checksum="CDD6B26C75913F4F" modified="2025-10-08" version="1">MVNLALQYLRLATRRNNLKLDIWFIQQCLKFKVFPTFSIVRTSKNVPPNIRTSLQIKLMKKEICSHYSKLNYINCKLKYSQDIKKCTTQHQDFTTDKTYEKRDMFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7W5</accession>
    <name>A0ABM5K7W5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506282.1">
        <property type="nucleotide sequence ID" value="XM_050650325.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650325.1">
        <property type="protein sequence ID" value="XP_050506282.1"/>
        <property type="gene ID" value="LOC126884421"/>
    </dbReference>
    <dbReference type="GeneID" id="126884421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="470" mass="52906" checksum="1EA4317E9F153D28" modified="2025-10-08" version="1">MCAFKVEHLLVDELDYELNIRDVVPEESATVDRKRNLLRGALKQEAGNRSFLQISAAHIPFEEQQKRISETLDSLSKKIEKFRGTVNDAEYARLTSRLAHISGRVHLLHCATEEQEPFKKSVSLRILTLEGELDSRVNPVATSTPNAPVNVSSFTYPKPVQVHKWGISFSGEKQHTDVMSFLERVECLRVSRGVSEEDLFAASAELFTGPAFTWFMNNRGSFSCWLDLIKRLKSDFLPYSFQDDLLDQIKNHKQKPGESVTMFINTILGMCSRLDTPLSDLSKIKIILKCLLPFYHQQLALMDIQNIDDLTVKCKRLEETLSWSSQPPSTSRSSSNSSSQPTSFRQRSWQNKGHEHNVSVVSSVVCWNCGQVGHPFYNCRIPQTRIFCHGCGLENTLKRNCSKCSGNEMSEFRPLSVSPSTSQSGNQTPSGNETVGPSTPSNSNPSSSRKGKRVPFKKQAHTTNQNQSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAC5</accession>
    <name>A0ABM5KAC5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050651183.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050651189.1"/>
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        <property type="protein sequence ID" value="XP_050507146.1"/>
        <property type="gene ID" value="LOC126884875"/>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
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        <property type="entry name" value="RT_dom"/>
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        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="332"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <sequence length="805" mass="92243" checksum="080AC1462CF58491" modified="2025-10-08" version="1">MVNLALQYLRLATQRSNIKLDIWFISRCLHNKVFPTFCRVRTSNNVHPNIRNAMQTKLMKKEICKHYSKLNYIDCKLKVTYDSLLETLHYINLNTFLSDVQDKVDRSHSVKFNRVNNKLQHLVNNKIRLDQQKASHNKSFSNFRFHPRIKNLSNVQFSDDELKLLNLGLKHSIPTNLSIRDLESLSIETDTVIQNLSISLTQKTSIRNSCIQTINKFKTKLLSNNNSSISNINSSSTSTSSSSFPNFSFNKSKSLLSTLKSIKNKIKNQHLIFSKADKGNCLVILDQQLYIDKVTSFLNNNNFNLLPVDPSKSFVSKMKNNLKQFTDFFSEYEAPYTKIPSNPLTPRLYGLPKIHKVDIPIRPVVSFINTPVSILSKFILNIIKNFINFTPQFTVLNSRQLVEKLQLVNLNPNIVMLSFDVSNLFTSVPKNESISLVNSLLLNNSVTSTTTSSIINILKICLSQDYFVFNNNFYQQPDGLAMGSCLSPFLADVFMDHLESNHITKNPEILHWFRYVDDILVLISGNSDSAHNLLHKINLIHPKITFTMELESSNSINFLDISITRLDDHFNFGIYRKPTQTDHVIHSTSNHPLSHKLSAFRSFIHRLNSIPLSTPEFNKELNIIKQIAVNNGYDPDIIHKLQQKRELKLLQQSAFSSSSTTTPIYASLPFNNSKLSERVKQIISNSCDNIKISFKVNNTLNKSLTNTKDPIHYMSRSGVYRLSCSDCDATYIGRTYRSLSTRSAEHSKRDTTSAFSHHLKVNKHELKIPDGVQLIHNIQQKKYTPFRLIRGFGNCQRPKEKSQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAQ0</accession>
    <name>A0ABM5KAQ0_DIAVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050651305.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050507262.1"/>
        <property type="gene ID" value="LOC114326001"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="422"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EnsemblMetazoa" id="XP_050507262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1016" mass="117556" checksum="80513D0B061BA76D" modified="2025-10-08" version="1">MFLILTIRQEILSKEGKIADEKRDPKHGKSIDRDYYVVRPIPPPFLISNYRKPSRLPVLFTLRSKRPPPITSKPYTVELPLISLAALQQHAIHQMIPFANYKHSPNSHQNPYIKNIPFHLAPISPPTQVHEPQPIRNVEYERDEKRTQKYVPIILPTERPENEAVRHNNGPPHYRVPTRINVENTEEVNVYLKAKIQASLAIEAPFKDFRLMQELFNYPNRRIATVTSQKLQKHLWYLSEHLIPMSLFGSRILPESKRLMVAAMQKEAPEHPPKHATDTKSSAFLESRDITNHQYQPNVEIIKAVGFYVPTEVPHDNLENIKDHFIDLAATEGVRHIPEGEQDQVTNERIPPAYTEDSNVGLDTEEELNDMETVYINHQNQYGQFDRKSAMLEDSKVSSPKNIYDIMDSPKYNDTFEKRTRKETVLSKPNKTKDLYTEEESEEEIESKLDCNEDSCNSEDADNTSSTEDNKYTSEESYEKEVNKEEPSEEDTASNLECEDGNCDSEDEITVYSNEKYETLITTEVDKIKRKKNEGNKGEIITEIECKGSDCALLEEEVKMSDDEENLKVISLNDRIDSNTKLVLVLPPENVVVSKKTHKKRSTDDSFNVNIGAGYGVGVDQNLNLPNSTTTINSANYITGLLKNEAVIVGRPLQPLPQPEGEMLESRSIPVKTEVKQEEPKKGVMNFKEIQQIIHNVDDNSEYSKIVQVVKVPAVYEIHLEKVAPAKKAVSDNNKKYIHPINNLLNNPKKILSKTKIKPNRSNNYVKIDDWQVERDREQRRWHPNPIRNINPHTNFQGVEYNNFNKPIIRENNGHEIVRQKKTTQLGQNHFPFYQPTIYTNNLYRPQPITFETPRYNLQPTSPKKAVYSTLSHIVPYNLRRRFQDPVQRSEVRDNNFVYGSHKEKVLNPDEINITMQPGTTVVTLPKLESEHERNFVVTDPPVKPCQQGYRQSETKELMEAVESKVDNVYFTTNRPFSKDHKDRSSRVFNKMSTRRHDLVPVKYILYIDRIYHDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBN0</accession>
    <name>A0ABM5KBN0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507595.1">
        <property type="nucleotide sequence ID" value="XM_050651638.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651638.1">
        <property type="protein sequence ID" value="XP_050507595.1"/>
        <property type="gene ID" value="LOC114328936"/>
    </dbReference>
    <dbReference type="GeneID" id="114328936"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="51"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="47"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="48"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1808"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1907"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1959"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1987"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="2015"/>
            <end position="2042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2068" mass="242316" checksum="ED84673F4B9D7772" modified="2025-10-08" version="1">MADLFKNEPENVSFEFTELEDQIKPYYIDKGVRPKEIKIEQCNNDLKFEVNENALKYQIVHTEEMELEPNVMDDNSKDAEINEKGVHSLVVKDSVVGNMLEDEGEKQFQCTICFKQLASKNNLNRHLLTLHKGIKAFYCKICGKRFTAKTSLINHVRSHYGERPFKCKDCPRRFNNRSALNTHTRLHTGQNLLKCEYCSKQFTGNTQLQIHLRVHAEEKPFKCTICSRQVTTQNSLNRHLRNHKGIKLFQCRICGKRLTTKPSLDYHVLAHYGERPFQCNVCLRQFRNNSLLNKHTRLHTGENLLRCEYCSKEFTVNSQLQIHLRVHAEEKPFKCTICSAQFTTNPSLNRHLFNHTGIKPFECGMCSKRYTSKTSLIHHMRSHSGETSSIQCDICSQQFKDQSLLTVHMKLHTDEKLLKCEYCSKQFTGNYKFQIHLLTHKGDKTFKCDICDKKFSNNDECILHRSTHTTNSPEQEQGDKLFELETIGDKEDKPFECDICYKKFWDNDQFLTHKRTHTIENSFKCQICFEDFTESTTTLATHMRLHTEEKLFKCDKCPKEFRKKYLLQRHLRRHLKKHVGNKPFECDLCDKKFSYNNECILHRSTHTTDSVENQLDKLKCGICSQVFTENDQLAQHKFVHIEEPQQCVVESLKFKQIDSSIENLQCNIKETSFKSNICSEEFSESDQLTQHMVLHTEETVLQQIACDNSFRMSPKTGQTTDERQHRDLFKNKSEKVSFKSTEGKDQIKPKYHSNEIQTEKCNNDLKFEVNENDLKYQIVHTEGMEFEPNVIDDNLKDAERNEKGVHSTVVVNDSVVGDMLEDRGEKLFQCKICLKQFNQKQNLHRHFSTSHQGIKAFCCKICGKRFTAKTTLIHHTRTHSGETPFKCTICPKQFRDKSSLNIHMRLHTGEKLLKCEYCSKQFTGNYKFQIHLRVHAEEKPFKCTICPTQFTTKASLNRHLFNHTGIKPFECGMCSKRYTTKASLNYHFQSHSGQASSIQCDICSQQFKDQSLLTVHMKLHTDEKLLKCEYCSKQFTGNYKFQIHLLTHKGDKTFKCDICDKKFSNNDECILHRSTHTTNSPEQEQGDKLFELETIGDKEYKPFECDICYKKFWDNDQFLTHKRTHTIENSFKCQICFEDFTESTTLATHMRLHTEEKIFKCDKCPEEFRKKYLLQRHLRRHLKKHVGNKPFECDLCDKKFSNNNECILHRSTHTTDSVEQVFMDPQKLNLQMKVHLDKLKCYICSQVFTEDNQLAQHKCCILHRSVVHSLGSLEQVFKDPQKLNLQMKVHLDRLKCYICSQVFTEDDQLAQHKCIHIEEPQQCIVDSQKIKQIDSSIQHLRCHIKETIFKCNICSEEFTDSDQLIQHMVLHTEETVLQQIAGDTSSRMSPETGQTTDEKQHRDLFKDKLENVSFQSTEGEDQIKPNYHSNEIHTAQCNNDLKFEVNESDLKYQILHTEGMEFEPNVINDNSEDAERNETGVHSTIVVNDSVVGDMLEDRGEKLFQCKICLKQFNQKQNLHRHFSTLHQGIKAFYCKICGKRFTSKASLIYHVRAHSGETPFKCKVCPRQFRDNRLLNKHTRLHTGENLLKCEYCSKEFTGNYKFQIHLLVHAEEKPFKCTICSAQFTTNASLNRHLFNHKGIKPFECGVCLKRFTTKTSLIYHIRSHSGETPFKCKICPKQFRNKSRLNRHLRLHSSENLLKCEYCFKQFTENCEFQRHLSTHKPFELKTIGDQPFECDICYKKFWDNDQCLTHKGTHTIENSFKCQICFEDFTESTTLATHMRLHTEEKSGMLRTYPQKPVEDKPFECDKKFSNNNECIRHRSTHTTDSPGQVFIDPQTLNLQIKVHLDEFNYDICSQVFTENDQLTHHKFVHNEEPQQRIVDSLKFKQIDRSIENLQCHIKETIFKCNICSEEFSDGDQLTQHMVLHTEETVLQQIACDTSSGMSPEVDQTIGEKPHKCEICLKGFKTKTFLKKHIKFHTGKKILRCKYCFKEFTQLSTLKNHMRSHTGGKPFRCKFCSMRFNWNNNLSRHLQNHVGEERLQEISCENSSINMATENNSNHPMLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCI3</accession>
    <name>A0ABM5KCI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507903.1">
        <property type="nucleotide sequence ID" value="XM_050651946.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651946.1">
        <property type="protein sequence ID" value="XP_050507903.1"/>
        <property type="gene ID" value="LOC126885384"/>
    </dbReference>
    <dbReference type="GeneID" id="126885384"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="276" mass="30470" checksum="21D20C84A0470D85" modified="2025-10-08" version="1">MTDSTSANNSASVLQDNSASVDRISVKIPPFWPNDLEIWFLQVENQFALVNITSDAAKFNYIVANLETVYISELRDTIVSPPATERLLKHEELGDRRPSQFLRHLQSLAGTTVPDNIVRSLWLGRLPSSTQAILAAQAKASLDAVAELADTISEAIAPGVHISGASNARESTIDKLTAELAEMKIQLANLSQAQAQPNTYRRNRSNSRGRPYPRDRSYSRELHDKTFTSVSSRSGGWIAMLTSNIGPNKDWTRITSEKSTKTPQTTKLRGNRHGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCU8</accession>
    <name>A0ABM5KCU8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508017.1">
        <property type="nucleotide sequence ID" value="XM_050652060.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652060.1">
        <property type="protein sequence ID" value="XP_050508017.1"/>
        <property type="gene ID" value="LOC126885485"/>
    </dbReference>
    <dbReference type="GeneID" id="126885485"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60999" checksum="F5A218ADE0D8DEAE" modified="2025-10-08" version="1">MPMKASDFRQLYRKRDIIEQRLNNFIKFIESMTNIAINDLSEDHFSQIEWNTERTESLVTEFDEIQMSIELNCQDQDIQQEYAKRQRLDTIFSKTLSKARTILKRKCSDSSSSESKRLDINHEYSGLEGVKLPPIQLPVFHGDYLTWIEFKDTFEGLIHNNKVLADIQKYHYLRASLKSDALKIIQSLDFSAQNYNSAWQTLCNRFDNSRMLVNNHLKALFEIENLNKESALGLRSMIDSVKKHLFALKSLQLPTEHWDAIMVYLVSGKLDKFSSREWEKRKIDNSLPSLNEFLEFLKNRADFLETIELSNVTKPDYKSNYQDKRSRSLLTSKSRSCNFCKQNHLIYLCEEFLKLSVTQRWDKIKQLNLCRNCLCTGHSYKQCKSFGCKICKAKHSSLLHENKPSDIHVKENSSINFNPNNDSENEPNKVKLSTNTSENNVNRNEIVLKNNCSNNDYVLLSTAKVRVYDRYGNTHIARVILDSGSQSCFITEDFLMFLINLGDLCLNGLGAVQGGEYGRKVLFIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDE4</accession>
    <name>A0ABM5KDE4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein turtle</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508214.1">
        <property type="nucleotide sequence ID" value="XM_050652257.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652257.1">
        <property type="protein sequence ID" value="XP_050508214.1"/>
        <property type="gene ID" value="LOC126885627"/>
    </dbReference>
    <dbReference type="GeneID" id="126885627"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF92">
        <property type="entry name" value="PROTEIN TURTLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="59"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="169"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="260"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="356"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="452"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="545"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="667"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1251" mass="138681" checksum="5B956842FB972268" modified="2025-10-08" version="1">MGMCTNPKGKSRPLTTATVPVQAQRSFTLYTVLTALFTFVLLQTVHCMQDAVHITAILGESVVFNCHVEFPEGHPVPYVLQWEKKVGETGQDIPIYIWYESYPTHSGEGYEGRVSRVSPDSPYGAASLNLTNIRESDQGWYECKVVFLNRPPNQPKNGTWFHLDVHAPPRFVVTPEDIIYVNLGDAIILNCQAEGTPTPEILWYKDANPVDPSSTIGIFNDGTELRISNIRHEDIGDYTCIARNGEGQISHTARVIIAGGAVIMVPPTNQTKLEGEKVQFNCEAKAQPGNVTVKWFREGAPVKELASLETRVTIKRDGSLVINPVSSDDSGQYLCEVSNGIGEPQSASAYLNVEYPAKVTFTPTIQYLPFRLAGVVQCYIKANPPLQYVTWTKDKRLLEPYQTKDIVIMNNGSLLFTRVNENHQGRYTCTPYNAQGTQGSSGQMEVLVRKPPTFTIEPETMYQRKVGESVDMPCDAVEAEGTQKPGIQWQRRDGTPLPKNRVKLVGGNLTIESIRRLDFGFYQCVATNEVATILTGTQLVVEGTQPHAPYNLTGSSTEFSVTLSWLPGYSGGPDYKQEYTMWYREAGTSDWSTIPVTPPGSTIVTISRLAPGTMYEFQVIGKNALGDGMMSKIISVRTVEVGQQKPIKITPTPFMTPNDDAGPKPGVPRNLTVNEISNGFLITWMPPIERAELIEQYVIKYKTDGPWKTLNKAQIRPEDTHYLVKNLVGGRTYYFRILAYSGKSYETSEQVKFSVPARVKHKALTAGVVGGILFFIVAITLSVCAVKICNKRKRRKQEKAYNMVACRITDSRNGGNATESQVPLKKLRKGRIPGLRVLAFIANWIWPKDRCRSGSLSSLTWHPDYLHPGSPSKSLARISRAADGRFVLVDSVLSLRAESSSNISSSDDGGFLPKRGAKNRASWRRPLVGYPSELSLRSDASGQSASGFPSFFMGTRYQQPALKPIQTIYSPQTPQFMSSSPATSSGLLLSPWTPMYFSDLSSVRYTSSGERSYPTPPGFMQLKSVHERYSQELPPLKAIHEEHQGFIPVHPIRDSPRAIPQHRLIRGSRFLPPRHARIARSAPELDHLDRSPESRSSSSGFGSKNTSQQNQSSHSGSTFMSWGLPPYRPPPPVPSMLPPPPPSLVGHWLDIASSSPSASDHIHKAVDVGSVDGHYEFDPSTPTPTPSTPTGSRDIDLDTSGPGPPMRKSYGIIRSRYDNIDARVQAMKEEFNEFRKRQANRKRSQELESVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEH7</accession>
    <name>A0ABM5KEH7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508595.1">
        <property type="nucleotide sequence ID" value="XM_050652638.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652638.1">
        <property type="protein sequence ID" value="XP_050508595.1"/>
        <property type="gene ID" value="LOC126885867"/>
    </dbReference>
    <dbReference type="GeneID" id="126885867"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF169">
        <property type="entry name" value="ZINC FINGER PROTEIN 723-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="575" mass="67365" checksum="CD32C409BC670B04" modified="2025-10-08" version="1">MEVKQEHNEEACKIEIEYNDLDGFKCEIQEESNSKSTHDTTYDYLDLKEHLVVNPKIEQHDNKLNPFEENQQNENGYLQEENKMEITETPIGHSSTEGSYMRTHAEGTTLNENVKVTTVQGPYKCEICFKQFNEAGNLKTHLRVHIEEKPHKCEICFKQFSQADGLKRHLRVHTGEKPHKCEICFKQFSIKSNLKTHLRVHTGEKPYRCGICFKQFSEAGNLKTHLRVHTGESPYKCDICFKQFTRIYYLKIHMRLHTGEKPYRCEICFKQFSEARTLKTHLSVHTGEKPHKCEICLKQFNNERNLKKHLRVHTGDKPHKCEICFKQFSQAGGLKRHLRVHTGEKPHKCEICFKQFSIKSNLKTHLRVHTGEKPYKCEICFKQFSLAGDLKNHLRVHTGEKPYKCEICFKQFSEARTLKTHLRVHTGEKPHKCEICFKQFSQAGDWKRHLRVHTGVKPHKCEICFKQFSQAGHLKVHLKVHTGEKPYKCDICFKQFSEAGTLKKHLRVHTGEKPHKCEICFKQFSEAGTLKKHLRVHTGEKPHKCEICFKQFSEVGTLKKHLRVHTGEKPYKCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF68</accession>
    <name>A0ABM5KF68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 271-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508847.1">
        <property type="nucleotide sequence ID" value="XM_050652890.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652890.1">
        <property type="protein sequence ID" value="XP_050508847.1"/>
        <property type="gene ID" value="LOC126886050"/>
    </dbReference>
    <dbReference type="GeneID" id="126886050"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="864"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="948"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="976"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="127022" checksum="E1FAED178343D6F8" modified="2025-10-08" version="1">MRPGQILDRLCEESPSKKFQDMLEIALNKEAALREQSRNNAEVNKLQVVKQKSSSTSTSSSNISRNGEKRVERHGDREEDPEDLRCNFCNKTKHNFSKCKYRTFICKKCGRKGHIMAACKLDRNHLVEEEEQENILSLYNLTNVQQVNFIRPLCIPVVIDNKVSTQMELDTGAGISCMPYKFYLDHLSYIPLNKTGIKLKTYSGEIVNPEGKISRHLNQIRRNQSDIVEDQVEKVDREGPENKCLSGEQGPSAIHFPKLDLNVQPKLLLNESVNEPYAQTNESQGQEEIKIDEDLADQPYPQAASEVTAKKGQVNISERPKRYLQEENKMEITETPIGHSSNEGGYMSPHAEGTTLNENTGEKPYKCEICFKQFSQACTLKTHLRVHTGEKPYKCDICFKQFTRIYYLKRHMRLHTGEKPYKCEICFKQFSEARTLKTHLRVHTREKPYKCEICFKQFSEAGTLKKHLSVHTGEKPYKCEICFKQFSEARTLKTHLRVHTGEKPYKCEICFKQLSEAGTLKTHLRVHTGEKPHKCEICLKQFNNERNLKIHLRVHTGEKPYKCEICFKQFSEAGTLKTHLRVHRVYEICFKQFSEAGTLKKHLRVHTGEKPYKCEICFKQFSEADTLKKHLRVHTGQKPYKCEICFKQFSEAGTLKKHLSVHTGEKPYKCEICFKQFSEAGTLKKHLSVHTGEKPYKCEICFKQFSEAGTLKTHLRVHTGEKPYKCEICFKEFSVASTLQRHLCVHTGEKPHKCEICFQQFSQAVHLKRHLRVHTGEKPYKCEICFKQFSEARTLKTHLRVHTGEKPYKCEICFKQLSEAGTLKTHLRVHTREKPYKCEICFKQFSEAGTLKKHLSVHTGEKPYKCEICFKQFSEARTLKTHLRVHTREKPYKCEICFKQFSEAGTLKKHLSVHTGEKPYKCEICFKQFSEARTLKTHLRVHTGEKPYKCEICFKQLSEAGTLKTHLRVHTGEKPHKCEICLKQFNNERNLKIHLRVHTGEKPYKCEICFKQFSEAGTLKTHLRVHKPLWGEGQDVKIGVEVRLMIWIVALKYNCNKVLNKDCLNNSTWWQRTCKYSEEYLASRTFFEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFY4</accession>
    <name>A0ABM5KFY4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509111.1">
        <property type="nucleotide sequence ID" value="XM_050653154.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653154.1">
        <property type="protein sequence ID" value="XP_050509111.1"/>
        <property type="gene ID" value="LOC126886283"/>
    </dbReference>
    <dbReference type="GeneID" id="126886283"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008737">
        <property type="entry name" value="DUF1758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05585">
        <property type="entry name" value="DUF1758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="4">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="690" mass="77682" checksum="0838A345106486B2" modified="2025-10-08" version="1">MANNNNNTVMLKSQRSTCKAQLTRIEKFIKGDSDNLHLIRVKFDNLAENYNKYKQIQSDIEMLKEPDSVASDSEENEVVADRFEIALAQLQELIEKLSKPNKVIDSVSNVKLPDIQIKPFSGKPEEFLPFFDLFSSLVLNNPKLKSQSEKFYYLKSLLKGQPLSLIESLPVTNQNLEVAISTLRNNYEDKNKLLNSLYQTLLDQKPINKCNASEIRSFYVTSKKTLDLVKNLKLSDHDTLDTLLVFLLEKKLDFQSRRAFESERDLTTLPSVDLFFEFLRKRYTILENLNMFDGNSKHDNNFTKNSDKSSPKINLHANVSDPNTRNISSTGKYCNYCNERSHSTYVCTKFLKLSPQERHRFVKSKSLCFNCLSSMHILSSCKSLSRCHHCGRDHHSLIHLETNSQRVGDQQRGQNVAQNNQHSRHIGNRNNVFNRDFNPSLTQNSTFLTQNSPANLSVSDANNASSQACSSTSTTNLSALSKNNCQILLPTAQAKVYSRTGKPFSVKLLLDSGSQQSFVSKDLANRLQYPTRVQKLSISGLGNNGLVQSNEILDIVLHSKLNPYQQFDVSCSVIDRITERLPQIALNPHGLKIPDHIIHELADPRFWEPSNIDILIGADLYFSLLKGDLISLGHNQPTLLETAFGYVVAGPVPNLSHKKISSIAPNTHSFLSVQDANNLAPMAGGPSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG15</accession>
    <name>A0ABM5KG15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509139.1">
        <property type="nucleotide sequence ID" value="XM_050653182.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653182.1">
        <property type="protein sequence ID" value="XP_050509139.1"/>
        <property type="gene ID" value="LOC126886308"/>
    </dbReference>
    <dbReference type="GeneID" id="126886308"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF20">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="210" mass="23991" checksum="5CD124B33E68D6D0" modified="2025-10-08" version="1">MLNLSLQGRNQTVSDLIGMINGFRNKLNVFKRDLEKNNLTHVPSCLQIAEEFSGEENIEFSSCISQIEQVIDEFNTRFEEIDSLKSSVLLYNNPLGATIDDQPPNLQLELCDLQADMFLITRQEKGPEFFKLLSKEKFPNLRDFGLKMTSMFGSTYTCESAFSSMKYIKNKNRSNLTDSSLRHLMRLSTTELEVDISSLVDEADRPQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIZ2</accession>
    <name>A0ABM5KIZ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rho GTPase-activating protein 26</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510169.1">
        <property type="nucleotide sequence ID" value="XM_050654212.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654212.1">
        <property type="protein sequence ID" value="XP_050510169.1"/>
        <property type="gene ID" value="LOC114326341"/>
    </dbReference>
    <dbReference type="GeneID" id="114326341"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01249">
        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07602">
        <property type="entry name" value="BAR_RhoGAP_OPHN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11882">
        <property type="entry name" value="SH3_GRAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="265"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="378"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="784"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="97182" checksum="209C8C4C532ECC2B" modified="2025-10-08" version="1">MGVVLPPLEFTECLSDSPHFRENLHKHERELEKTNQHIKRIIKEVKDLLTAAKQLGRAQRSFAECLKSFTFECVGGTQTDDEQVICASLSNFADLINQIEDERDRMLENANCSVVKPLEDFRKKYIGGAKNEKKKFEKQTAKFCQNQERYLNLTTKKTNSLQEADASVDMAERHFYAASMDYVYLIQEVHERKKFEFVETLLTFIYSWFTFYHQGYELKKDCDPYWKDLQAKIQKTRNNFDGFSQQLKKRMSEVQKQDEPIRNAKGCREGYLFLLEKKAFGTTWTKHYCSYDKETKVFSMLPYNQLTTKTLSPPDKMVISSCVRRMSDSIEKRFCFDLVSDEKPGVTFTFQALSDQDRKAWMDIMDGKEPTYTIPNNVSKNNVEERILDDNGIQFVKKCIDMLESRGLEEQGLYRVVGVSSKVTKLLNMGLDRRKNDKLLLDDPVEWETKTITSSLKMYLRNLPEPLMTFRYHNGFIAAVKNESKQNRIRDVHTLLYRLPKINFEVLKMLMKHLTNVVAKCDKNLMNVSNLGVCFGPTLLRPEEETVASILDLKFYNIVVEILIENYQRLFFNEPGSVPPHVQPVSSNNSQSIYGPPNNHLPTYMSTEEGLNSRTYMEPSKVLASYRERDFPQQYTCTVSTHVEPRISSSMYSVNESTNGSFDLSRSEHISPRAALNHQHKFKQMIPSIVSQSETNLPVLHNYSPPNFRPYSNRLETNSTSSSNESLSSTSRDGNNLIGMLPKKSKRSYYMGYPKNYKSPGYVKLHSPTLVTNTSSRRGSPTPNRVRRVRTLYACLGEQDGELSFEPNQIITNVKSSQEPGWLEGTLNGKTGLIPENYVEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ99</accession>
    <name>A0ABM5KJ99_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 CYP12A2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510173.1">
        <property type="nucleotide sequence ID" value="XM_050654216.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654216.1">
        <property type="protein sequence ID" value="XP_050510173.1"/>
        <property type="gene ID" value="LOC114326342"/>
    </dbReference>
    <dbReference type="GeneID" id="114326342"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="62086" checksum="99043D24409AB004" modified="2025-10-08" version="1">MSLAAMLSRRALRLKCSTLLKTATYSTAPASTATNRDNFYQNIAGAQNDDTNPEGWENAKPFDSIPGPKPLPVLGNMWRFFPGAEFHNINTDKLFLLFQQRYGDVVRLGGIWGRRDKIFLYDTGDMEDMLRNTGPFPSRFIMDAIFYYRRKLRKDIYKGNLGLALLQGEEWYKLRKIVNPILMQPKTIQQYTTRMDGVAKNLMKLISHRMTSSGTNTTPDDFEKDLYKWALDSVAIIALNRQLGALNAHADAETTKFVLSVLRLFDQSFYLEQMPPYWKYLPSKRLKDYCDNLDFITDVLTRMIDKSLAEFKNEDGVPDEELGVLQRLVKLDKQTAVIMTMDMITAGVDTTGKTLGAVLYFLARNPDKQSILREEILKYLPEKDTVLTADNLNEMQYLKAAVKESSRIAPIAITSLRTASKNMIVRGYQVPKGTDILPMHHYASTLTDKNFKEPSKYIPERWLRSVSNEYSAKNAHPFAYMPFGHGARSCIGRRFATLEVEVAVANMIRNFELSWDQPDLRFEARLLYGFIDPLKLTLKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KK24</accession>
    <name>A0ABM5KK24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050510468.1">
        <property type="nucleotide sequence ID" value="XM_050654511.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654511.1">
        <property type="protein sequence ID" value="XP_050510468.1"/>
        <property type="gene ID" value="LOC126887149"/>
    </dbReference>
    <dbReference type="GeneID" id="126887149"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047517195" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="45469" checksum="EB03C6D300B4B2EF" modified="2025-10-08" version="1">MFEFQNNYLKLFIFLALCTLLETTEFDPLGYILYCPCMGRFGNQADHFLGALSFAHGLNRTLVLPPWVEYRYGESKSIQVPFDTYFKVDPLQKFHKVLTMENFMKNVAPYEWPETGRISFCYMARGGSGDSCNAKDGNPFGPFWDTYNVEFVTSEFYGPLHYDVHHHDMIKQWREKYPPKKWPVLAFTGAPASFPVQQENLPLQKYLEWSDNIEKKADNFIKKVLPKGAFIGIHLRNGIDWVRACQHIPESPGLFAAPQCLGYRNEKGPATSDMCLPSQEMIIRQVKRVIKNINNSVNNNNDRTIKSLFVAADSNHMIDELKSGLHRMKVKVFKYPESDPHVDLAILGKSNHFIGNCISSFSAFVKRERDVKGFTSSFWAFPTQKNSKTSATHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQZ3</accession>
    <name>A0ABM5KQZ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512604.1">
        <property type="nucleotide sequence ID" value="XM_050656647.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656647.1">
        <property type="protein sequence ID" value="XP_050512604.1"/>
        <property type="gene ID" value="LOC126888404"/>
    </dbReference>
    <dbReference type="GeneID" id="126888404"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20923" checksum="51E243F8E5FF8412" modified="2025-10-08" version="1">MRYRRDRSRLRAVSNCRIFKKVFLACPILHLTSCCWSKVSCIQYPGYLNVFTCSTRLLLTRMFITGKKILEMKKVPDGLEVISIKSLSTVKYDYLKTTICDNMVYTLYREQMMNGYRYSFEKCNLDTHEMDIIFDGLKTLQVEENIFNLDLPDHSLNIFSVSHHKLFDENELVNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS63</accession>
    <name>A0ABM5KS63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050513024.1">
        <property type="nucleotide sequence ID" value="XM_050657067.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657067.1">
        <property type="protein sequence ID" value="XP_050513024.1"/>
        <property type="gene ID" value="LOC114335227"/>
    </dbReference>
    <dbReference type="GeneID" id="114335227"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="502" mass="55705" checksum="4F8CEFF77E8F5BD0" modified="2025-10-08" version="1">MLPFGGNTVDPTKHELKPHTGSRKKSKSMQALDKGTASVHAYLIPHCPRELPIRETSFNVPQYYNDVRDYYHPYDYHGSIESCSCSSGSDTSRTTFRGPWCVCIVICVIVATLTAGLGLPLALGPHLPPQTTEERLNLVKKLLKEQPLIDGHNDLPWNLRKFVHNKLFKLNLSAISEEEPWSTSKWSHTDIPRLRAGLLGAQFWSAYVPCKAQHIDAVQVTLEQIDVIKRLVDFNSNHFSLVRSTQEIRSVHKEGKIASLIGVEGGHALGNSLAVLRTFYNLGARYLTITHSCDTPWATGTNTKTQDGLSEFGKSVIKEMNRLGMIVDLSHTSMNTAKAALNVSRAPVIFSHSSAFSLCNSSRNVPDDVLKLIAHNGGVIMVNFYNYHVTCNETATIQDVINHINHIRSVAGIDHVGIGAGYDGINMTPSGLEDVSKYPYLFAELLADPSWTEKDVISLAGLNLLRVFEQVEEIRDKSKKQEILPLEDNIPPMHNPCSSLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUT1</accession>
    <name>A0ABM5KUT1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2HC/C3H-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513944.1">
        <property type="nucleotide sequence ID" value="XM_050657987.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657987.1">
        <property type="protein sequence ID" value="XP_050513944.1"/>
        <property type="gene ID" value="LOC114337269"/>
    </dbReference>
    <dbReference type="GeneID" id="114337269"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF68">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="627" mass="70275" checksum="4CBB26A264B63049" modified="2025-10-08" version="1">MPHKPKSRPFLVLPLLESDLLERASPNLLDMPTKNPGLHLFTKTFPSHKKRKDSDENKRPLTATLEKPTILDIRLIGKIDMSKIRKEFLNISNLCRLPILLKKSKNSKPHRPLSLPPPAIEKKKKAKDADDLSILSMGEEEESTQSVRVTGRHASKLKSINGKRTVKTCDDNNNNSSRTIRIPRRSPAALPSDNKPIGSAASDTKSTKLPQPCNSCGRSDQPERLHSHPVTPIAANSPKLLVKATVQKPVPLKYKSSKSKKEKSKKTPSPTRKPSLPSQNIVHSNPSSANMLAAKRLEIMKKMQEGNDSRASSSGKRTLTCYICGREYGTSSLKLHEPKCLEKWERENSSLPQHLRRKLPVRPSGAVSSEEWNELAWEASQANLVPCPNCGRTFYPDRLVVHQRSCKQLPQSEFRNSNQSLTNVVLPPNTVIPSNRPSSGQGPPTAECSICGKKFGIHSLKVHEKKCYKQWTEANNSSEKSPPPSKIKTSPPEKRIENTSNSTIPSTALVSPVSSRTSPLFPCYICNELFDVNSIYKHEPQCLKKWKAENDKLPKHKRKQQPLKPDIKFTPSGGVDYVGTFNRIWENHLAELVECPKCGRRFFPDRIEVHIKSCAGLKLQFKDTKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY50</accession>
    <name>A0ABM5KY50_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505380.1">
        <property type="nucleotide sequence ID" value="XM_050649423.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515110.1">
        <property type="nucleotide sequence ID" value="XM_050659153.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649423.1">
        <property type="protein sequence ID" value="XP_050505380.1"/>
        <property type="gene ID" value="LOC126883759"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659153.1">
        <property type="protein sequence ID" value="XP_050515110.1"/>
        <property type="gene ID" value="LOC126890295"/>
    </dbReference>
    <dbReference type="GeneID" id="126883759"/>
    <dbReference type="GeneID" id="126890295"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="419" mass="48384" checksum="64D8A034A4DBC486" modified="2025-10-08" version="1">MSKRQYIRRGVQQQEPQPHIFDLYQKPLFDNTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFGIHETLLEIKGSIEKVGDGVVSLAPNAGAFLFDTCTYIQSSHDMEIVRDPGVVSTIRSLLCYTPEDSKFLSTAGWNYPNNPHISGDNFSLLIPIKHIFNIFNDYNKLTYGRQVFRFVRARNDRDCILVKEPNATTTITVSLTVSSMELKVKHVFPNDDMKIELMTPIKNNVPITIPFRKWELNELPSLTSGSRREIWSVKTTSSVERPRYVIVAFQTSKRDDIHADPTLFDHIRMSSVRLVINGEYWPNERMQLDFAKNDYAIAHYNYTEFFPSYTLSSTKHPILDYAAFKKYALFVFDCSKQDDTSFRSGTVDVKLEIEADEGFPAGTRAYCLIVHDSLLEYFPLTEVIKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY94</accession>
    <name>A0ABM5KY94_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515155.1">
        <property type="nucleotide sequence ID" value="XM_050659198.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659198.1">
        <property type="protein sequence ID" value="XP_050515155.1"/>
        <property type="gene ID" value="LOC114327815"/>
    </dbReference>
    <dbReference type="GeneID" id="114327815"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF67">
        <property type="entry name" value="GNOT1 HOMEODOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28608" checksum="0C8396FF0E2B8643" modified="2025-10-08" version="1">MLHHYNYSTSLSHFLSYHQLEDRSNDNDHQTQNLCDDLSQDEDARCRSNSSASNKSFTIAAILGLKNDNKHLGNPVSSATDLSVVNLSTGGDRSSGLISSCTRLQLPVHVTGVPGSAPPGGHFAPTNPSAVGQGCPPVRHNVRNPLKHMSQGVMGSKKSCKSKRVRTIFTPEQLERLEAEFERQQYMVGPERLYLAHTLQLTEAQVKVWFQNRRIKWRKHHLELTHQRLAVLKQQQLLLDDPQPDVQDTNSSGTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYI5</accession>
    <name>A0ABM5KYI5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515242.1">
        <property type="nucleotide sequence ID" value="XM_050659285.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659285.1">
        <property type="protein sequence ID" value="XP_050515242.1"/>
        <property type="gene ID" value="LOC126890390"/>
    </dbReference>
    <dbReference type="GeneID" id="126890390"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="183" mass="21028" checksum="7EA29CE8F5C8D98C" modified="2025-10-08" version="1">MLSECKLNLPNNEKLPGRAMAVPYVFLGDDAFPLSPNLMKPYPGTQEKGSQGRIFNYRLSRARRVSENVFGILSARFRVFRKIMLLEPTKAETIVTACICLHNYLRKKKSRTTYTPPGTFDSEDKDSGNIISGAWRNEMQNNMPFHSFDKRARKSSSAAKDVRQEFAEFFMTEQGNIPWQNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYW5</accession>
    <name>A0ABM5KYW5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515386.1">
        <property type="nucleotide sequence ID" value="XM_050659429.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659429.1">
        <property type="protein sequence ID" value="XP_050515386.1"/>
        <property type="gene ID" value="LOC126890465"/>
    </dbReference>
    <dbReference type="GeneID" id="126890465"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046457392" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="122" mass="12965" checksum="F8BED6A18184FD9C" modified="2025-10-08" version="1">MIAKVLVMMTVLVALTHGGLIGEIGLGSGLGLNGGISSIGIQGIALAGKQTVVDLIAPPKYEYKYAVEDPHTGDLKEQQESRIDDLTKSEYAVAEKDRKIQVSRIIGKSIPLVSKSISLGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZQ5</accession>
    <name>A0ABM5KZQ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515673.1">
        <property type="nucleotide sequence ID" value="XM_050659716.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659716.1">
        <property type="protein sequence ID" value="XP_050515673.1"/>
        <property type="gene ID" value="LOC114334749"/>
    </dbReference>
    <dbReference type="GeneID" id="114334749"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF6">
        <property type="entry name" value="BEATEN PATH IIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046215976" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="274" mass="31058" checksum="E280026B09BF53B8" modified="2025-10-08" version="1">MKGMYAEFVLSFLFIVLKKEIFCLKEIVLDIEPNVVEHGGTTKLSCSYNLQGEPLYTVKYYRGTHEFYRYTPKEHPSIKKFPFNGANIDLQHSNEHQVVLRDVGFNLSGKFSCEVTTDAPNFSTVTVSKDMLVVVLPTNSPSLSTDKSFYDIGDVLRASCTSPSSRPASKLTFILNNIEVCQTCFRNKTTVGELFESRMFMTLPLFESHFNNSRLTLKCVAKIGDFYHQETEIIFDNAKDPVPEKVTAQNEGVTKIYQKIVFLIPTIICISLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L107</accession>
    <name>A0ABM5L107_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516116.1">
        <property type="nucleotide sequence ID" value="XM_050660159.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660159.1">
        <property type="protein sequence ID" value="XP_050516116.1"/>
        <property type="gene ID" value="LOC126890979"/>
    </dbReference>
    <dbReference type="GeneID" id="126890979"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF33">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39084" checksum="45F2FAFB23F8FA7C" modified="2025-10-08" version="1">MSSYKHKSGALKRKLQKEKLEQSAKGRQDIKKFFKSNEKEELQEFQPDFNPEPTSASQTQPSSASIQNASTSTVCEGSNDECASADPNLSKDTVDDNKTFNFDDPNTWPAVMSDKIRQEIVLCYGGFQAFQARSKSFPADPSGKHFHETLLYMKTDNRTCKAIPREWLMWSETKNSIHCLPCSIFHSNQNKSKLAKEGFFPEKQQYKRLYRLFSMHERSSEHRKHYLEWKSLQISLKGHGVDSNLQQIINCEATRWKAILQRILDTTIFLSSRGLAFQGENTQIGDVHNGNFLGVLELIGKYDEVTREHLAKVKENQLNKKRTDDVYNSKRFGYPNFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L242</accession>
    <name>A0ABM5L242_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516511.1">
        <property type="nucleotide sequence ID" value="XM_050660554.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660554.1">
        <property type="protein sequence ID" value="XP_050516511.1"/>
        <property type="gene ID" value="LOC126891377"/>
    </dbReference>
    <dbReference type="GeneID" id="126891377"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35695" checksum="60A64EABF1590B91" modified="2025-10-08" version="1">MDKVVQTVNFIRARGLNHRQFQAFLSDVGSDHEDIVYFSSVRWLSRASTLKRFYSLLDEVKIFLENKGQEIDFLTDEQWLADLAFLVDITKYLSDLNLKLQGKDQLCTQLYEHIQAFTKKLILLEKQLEQKQLVHWETLSARNQEMLDLAKYVSLLQRLRNEFEERFVDFKLQIPNMKVFQNPFEIEIDGAVLNLQMELIELQSDSLLKTAYQSCLPNGLIEFYKKYINRNQYPNLTKLPLQQISLFGSTYICEQLFSRMKYNKSKTRSSLSDNHLTGILRIATSKIPVDIDTLCKQKKCQTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5Q4</accession>
    <name>A0ABM5L5Q4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517767.1">
        <property type="nucleotide sequence ID" value="XM_050661810.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661810.1">
        <property type="protein sequence ID" value="XP_050517767.1"/>
        <property type="gene ID" value="LOC126892301"/>
    </dbReference>
    <dbReference type="GeneID" id="126892301"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="33679" checksum="5BBED90276C33CBD" modified="2025-10-08" version="1">MLLLNTRRLSTNGSRWMVMLADDLKFWRVIDSLKDQALLQDDLDRLHNWCNQNKLHLNIKKCCFISFSRKVNRIETSYTINNMPLNYVSSIRDLGVIFDEKLTFCDHINTISIKASKLLGFVTRNCKYLSINSTRLVYCCLVRSILEYCLVVWSPYFQNSIDTLERVQHRFLRYCAYHVHTAIRNHDYSYIEQQLSLPPLKNRRDISGAIFIIHGFIDCPNLLNHIKFNVPKQALRYHQVFNIPFHRTTYGIHNPLDRYMGLLNEFDYDIFNLTLSRFKRSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L696</accession>
    <name>A0ABM5L696_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517961.1">
        <property type="nucleotide sequence ID" value="XM_050662004.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662004.1">
        <property type="protein sequence ID" value="XP_050517961.1"/>
        <property type="gene ID" value="LOC126892474"/>
    </dbReference>
    <dbReference type="GeneID" id="126892474"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4806" evidence="4">
        <location>
            <begin position="306"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="377" mass="43779" checksum="A3CA7098D4B58C95" modified="2025-10-08" version="1">MHVRLILKKLKLHLWLFWVYAACILLFLLFLLPYLLKSTTELLSGSNLIAHKIIKFYNILISYISFFYGTLETYKEFVEEMPWVVLRFPESETIEAVPAKWYDKANKLCKFPPVDDHTEKELSNFIIEEYDPLEEWPIHEAVLESQTEFVLFNKAHIRASKACNSQNYKSDKETVLPQKRPPKPRKIASSSSEQDSDGSDLVFEHSFPKSKKEQHEKCTPSKSRTHPNIGLENKQEVKTVQETSKPTPTNANAQETAISYLIRIKRTLELQEQKLSEIDRKVDELSTIIRGQQKSTDITDDEVHKKLPLSTLEELGDVEKLLENATNLDNFVIYMRQVGGFDYKESVRRCLKKIFNDQLAVIYSFQGHKGKIPLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7Q1</accession>
    <name>A0ABM5L7Q1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518465.1">
        <property type="nucleotide sequence ID" value="XM_050662508.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662508.1">
        <property type="protein sequence ID" value="XP_050518465.1"/>
        <property type="gene ID" value="LOC126892787"/>
    </dbReference>
    <dbReference type="GeneID" id="126892787"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="34188" checksum="BC54778F2581BC05" modified="2025-10-08" version="1">MLKNKKQGYEEFEEAKDMIRNHFKDGAALWFESKQNELQDWEEFERKFLKYYWGKEKQMVVNSELQNGKYDEKLGKSEEKYALQVYASGQYLNYNYSEEQLVELIARHFDNTMEDYVTLQGYRDMDSLCQFLVVREARRKERRTRRQTENNGNNQTNRIHNYRPSHNENTYRYNGYRDNEGQRYTNNFHQNRYEQNRNGYQQNRSQNNGKNYNSQPYQPNTGRENFNRGNQYNNHNGQGRERNREINNLSLIREGEGEQGHQEIDNVEVESNRAGPSFRESTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8G3</accession>
    <name>A0ABM5L8G3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518723.1">
        <property type="nucleotide sequence ID" value="XM_050662766.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518724.1">
        <property type="nucleotide sequence ID" value="XM_050662767.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662766.1">
        <property type="protein sequence ID" value="XP_050518723.1"/>
        <property type="gene ID" value="LOC126892910"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662767.1">
        <property type="protein sequence ID" value="XP_050518724.1"/>
        <property type="gene ID" value="LOC126892910"/>
    </dbReference>
    <dbReference type="GeneID" id="126892910"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="7">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="183" mass="20948" checksum="092313ED6E4EB300" modified="2025-10-08" version="1">MAKSTKTSWQQGLVKRMNDPDAVVTSDDLVTVINDLFPKAEVHWLVLPKENISSLTGLKKDHIDLLRHMKRAAQTAIKEEGHTDKKFKMGFHAEPSMSRLHMHVISDDFNSMCLKHKKHWNSFTTDFFLKPEDVIESLETHGKVCILTPAQCKTLIAAPLKCHKCDYKPKNMPDLKKHILSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L920</accession>
    <name>A0ABM5L920_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="14">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Mitochondrion inner membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="14"/>
    <dbReference type="RefSeq" id="XP_050518937.1">
        <property type="nucleotide sequence ID" value="XM_050662980.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662980.1">
        <property type="protein sequence ID" value="XP_050518937.1"/>
        <property type="gene ID" value="LOC126893040"/>
    </dbReference>
    <dbReference type="GeneID" id="126893040"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="11 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="16">
        <location>
            <begin position="166"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="529" mass="58667" checksum="ADE2108A273F8CB9" modified="2025-10-08" version="1">MPDIQPMIVGIFHGNNKPLDIKEFLEPFVEDVKRLQSNGLCVNGHMIHIKIRCFICDSPARAFIKGVVNFNGINGCLKCTTEGEYSYLSRIFRIPDIKCPLRTDAKFRSKHYGKHHKGQESPILKISEVDMVQDFIVADELHLLELGVMKRCLTGWKDGSMGFSIIGAPDIAFPRINNIRFXLLPPSLLLLLLRRMVERVVGTGXTVYPPPLSSNIAHGGSSVDLAIFRLHLAGISSILGAINFITTVINIRPIGITFYRIPLFVXAVVITAILLLLSLPVLAGAITILLTDRNLNTSFFDPAGGGDPILYQHLFXFFGHPEVYILILSGCGLISHIVRQERRKKEAFGTLGIIYDIIAIGLLGFIVXAHHIFTVGIDVDTRAYFTSATIIIAVPTGIKVFRXLATYHGTTITYRPVTLXALGFIFLFTVGGLTGVVLANSSIDIVLHDTYYVVAHFHYVLSIGAVFAIIAGFIQXFPLFTGLTLNNFYLKIQFFIIFIGVNLTFSPQHFLGLIGIPRRYSDYPDVFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA76</accession>
    <name>A0ABM5LA76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519338.1">
        <property type="nucleotide sequence ID" value="XM_050663381.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663381.1">
        <property type="protein sequence ID" value="XP_050519338.1"/>
        <property type="gene ID" value="LOC114339289"/>
    </dbReference>
    <dbReference type="GeneID" id="114339289"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14083">
        <property type="entry name" value="STKc_CaMKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="40425" checksum="6C9B60EBBBFEB643" modified="2025-10-08" version="1">MPLFGGKEKKQKKDGRDSDKQPSLEDKYYLKELLGTGAFSVVRLAESKDNPGIMHAVKIIDKKALKGKEDSLENEIKVLRRLKHPNIVQLLETFEDKSKVYLIMELVTGGELFDRIVEKGSYTEKDAADLIRQVLEAVDYMHEQGVVHRDLKPENLLYYSPDEDSKIMISDFGLSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGEFEFDSPYWDEISDSAKDFIRNLMCVNVEKRYTCRQALGHPWISGNAASNKNIHGTVSEQLKKNFAKSRWKQAYHATTVIRQMQKMALSSGSGGKSPTPQRSMSSQSGGTPCGSLNGAQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAN3</accession>
    <name>A0ABM5LAN3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519490.1">
        <property type="nucleotide sequence ID" value="XM_050663533.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519491.1">
        <property type="nucleotide sequence ID" value="XM_050663534.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519492.1">
        <property type="nucleotide sequence ID" value="XM_050663535.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519493.1">
        <property type="nucleotide sequence ID" value="XM_050663536.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519494.1">
        <property type="nucleotide sequence ID" value="XM_050663537.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663533.1">
        <property type="protein sequence ID" value="XP_050519490.1"/>
        <property type="gene ID" value="LOC126893396"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663534.1">
        <property type="protein sequence ID" value="XP_050519491.1"/>
        <property type="gene ID" value="LOC126893396"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663535.1">
        <property type="protein sequence ID" value="XP_050519492.1"/>
        <property type="gene ID" value="LOC126893396"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663536.1">
        <property type="protein sequence ID" value="XP_050519493.1"/>
        <property type="gene ID" value="LOC126893396"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663537.1">
        <property type="protein sequence ID" value="XP_050519494.1"/>
        <property type="gene ID" value="LOC126893396"/>
    </dbReference>
    <dbReference type="GeneID" id="126893396"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35799" checksum="55604AF05389E68D" modified="2025-10-08" version="1">MEKETPTNFCLLNKIALVCAFIVGIQVTRMVFKFLYDNFLSTFLQINAVNLSETGKWAVITGATDGIGKAFAEVLAKKGLNIVLISRTQSKLEDVAKELGQKYKVEFMILVADFTDTDQIYSDIEKKLTGLDIGVLINNVGMSYNHPEYFLDVKEKDKFFVNLINCNIFSVTNMCKIVMPGMVERRRGVVVNISSTAAQIPNPLLTVYAASKAYVVKFSEDLASEYAKFGITVQCLLPGYVATNMSKIRSSTWMAPSPIGYVTEAVKTIGVKEKTTGYFPHTLLVSFLNTLDCISPKLSRWVIFRTMTNIRKRALRRAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0A7</accession>
    <name>A0A6P7F0A7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PITH domain-containing protein GA19395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324622</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128292.1">
        <property type="nucleotide sequence ID" value="XM_028272491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F0A7"/>
    <dbReference type="FunCoup" id="A0A6P7F0A7">
        <property type="interactions" value="2087"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272491.2">
        <property type="protein sequence ID" value="XP_028128292.1"/>
        <property type="gene ID" value="LOC114324622"/>
    </dbReference>
    <dbReference type="GeneID" id="114324622"/>
    <dbReference type="KEGG" id="dvv:114324622"/>
    <dbReference type="InParanoid" id="A0A6P7F0A7"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000002">
        <property type="entry name" value="PITH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028128292.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23300" checksum="DD0C773D5002EFF2" modified="2020-12-02" version="1">MAPHGKCGDSSHSQESDEIGIHYSLYAKIDKENLECLNEATEGSGKTVFKPWEERLNFEAFVESDADEELLFNVPFVGNIKLKAIKIIGEDSETHPSRMRLFKNRPKMTFDDTSATPDQEFELVRDTTGAAEYVTKIVTFNNVNHLTLHFPSNFGGESTKIYYIGLKGEFFEAHHHGVTICTYEARPMAQDHKNPLNEINQSQLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2U0</accession>
    <name>A0A6P7F2U0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIRP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114324241</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127830.1">
        <property type="nucleotide sequence ID" value="XM_028272029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2U0"/>
    <dbReference type="FunCoup" id="A0A6P7F2U0">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272029.1">
        <property type="protein sequence ID" value="XP_028127830.1"/>
        <property type="gene ID" value="LOC114324241"/>
    </dbReference>
    <dbReference type="GeneID" id="114324241"/>
    <dbReference type="KEGG" id="dvv:114324241"/>
    <dbReference type="InParanoid" id="A0A6P7F2U0"/>
    <dbReference type="OrthoDB" id="6330326at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647:SF4">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="8">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028127830.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14916" checksum="EFD8CAF1989D594C" modified="2020-12-02" version="1">MHLQYTLIFIFINLYCFTCSPYYANNLSKRGEKYCGSRLTSMLNLVCRGRYYGPRNTRSTHNDVMNMDSDFVNSIDSDYSNNDVLYPYVSKDSVLSLLPNKIRKSHGIVNECCYNPCTVDTMKEYCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8E0</accession>
    <name>A0A6P7F8E0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114325995</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129958.1">
        <property type="nucleotide sequence ID" value="XM_028274157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8E0"/>
    <dbReference type="FunCoup" id="A0A6P7F8E0">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274157.2">
        <property type="protein sequence ID" value="XP_028129958.1"/>
        <property type="gene ID" value="LOC114325995"/>
    </dbReference>
    <dbReference type="GeneID" id="114325995"/>
    <dbReference type="KEGG" id="dvv:114325995"/>
    <dbReference type="InParanoid" id="A0A6P7F8E0"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000142">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="402"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028129958.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="89542" checksum="8EFBA9B6C918CE65" modified="2020-12-02" version="1">MLKVKGQLKFEDKWPQMGPIVLKLLKQEPVSPSEWQELFYDVHLVCLWDEKGPAKLRDHLHEDIVQFIKQAQSRVLAHRQEEALLKAYIAEWRKFFTQCNYLPTPFRQLETSLQGKPTSANPSVQNNSGKKATGEESIVRKLMLDSWNESIFSDIKYKLQDSAMKLVHAERNGEAFDSQLVIGVRESYVNLCSNTEDRLHIYRENFEAAYIQSTDLFYRLKAPEQLATNGVQAYMRYADAKLREEEARAQRYLEAGSYAVIQCCVKVLVGNALPVLLAECAPLIKAGETERLHLMFRLLERVPEGVQPMLQELENHITQAGLADMVAAADIITQDSEKYVERLLELFRKFSKLVHDAFSDDPRFLTARDKAFKTVVNDTTVFRLELSTGRNIGTKVVTPESKCPELLANYCDMLLRRTPLSKRLTSEEIESRLRDVLLVLKYVSNKDVFMRYHKAHLTRRLILDASADSEKEEDMVEWLREVGMPADYVNKLARMFQDIKVSEDLNGQFRTSNARHDAINIKILNAGAWARGSERVTVSLPVELEDYIPEVEEFYKKKHSGRKLQWYHHMSNGTITFATVGGKFDLDVTTFQMAVLFAWNQRPHDKISYENLRLATELPDAELRRTLWSLVAFPKLKRQLLYYSPSVTAPKDFTEHTVFWVNQDFALIKNGKSQKRGKVNLIGRLQLSTERSQLEDNQSIVQLRILRTQEAIIKILKMRKKISNAALQAELVDILKNMFFPSKKMIKEQLEWLIEHKYMRRDDDDINTFIYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDW6</accession>
    <name>A0A6P7FDW6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-like protein 1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114329337</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Lipid-anchor</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028134194.1">
        <property type="nucleotide sequence ID" value="XM_028278393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDW6"/>
    <dbReference type="FunCoup" id="A0A6P7FDW6">
        <property type="interactions" value="1063"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278393.2">
        <property type="protein sequence ID" value="XP_028134194.1"/>
        <property type="gene ID" value="LOC114329337"/>
    </dbReference>
    <dbReference type="GeneID" id="114329337"/>
    <dbReference type="KEGG" id="dvv:114329337"/>
    <dbReference type="CTD" id="41140"/>
    <dbReference type="InParanoid" id="A0A6P7FDW6"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028134194.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21507" checksum="CEDBAA48F4784255" modified="2020-12-02" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGDTCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDIGTYREQIKRVKDAEEVPMVLVGNKCDLSAWAVDMSQAREVAKQYGIPFVETSAKTRMGVDDAFYTLVREIRKDKSNRKKWSHGHGHGRGPFKLRCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHU2</accession>
    <name>A0A6P7FHU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynein intermediate chain 2, ciliary</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114328191</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132775.1">
        <property type="nucleotide sequence ID" value="XM_028276974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHU2"/>
    <dbReference type="FunCoup" id="A0A6P7FHU2">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276974.2">
        <property type="protein sequence ID" value="XP_028132775.1"/>
        <property type="gene ID" value="LOC114328191"/>
    </dbReference>
    <dbReference type="GeneID" id="114328191"/>
    <dbReference type="KEGG" id="dvv:114328191"/>
    <dbReference type="InParanoid" id="A0A6P7FHU2"/>
    <dbReference type="OrthoDB" id="10261376at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028132775.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="83963" checksum="581DAF8403A8814D" modified="2020-12-02" version="1">MKNPPANLKKTPSTVGNAGSQKAKRNLKKEETSDDLEEWKKAKQLLKPKDQLELTDAELKEIIPKQLTSTNPQIPEGLIEWSYLQAAFVQLPSPGNMVTVFSQEGTLLHKESEEARQQMVEMGIDPSEFFSSEVTLIPEATPEPSIHEQEPEPEATEEEAAKEEDAESRVTVMEEEEEKGPEPEKQEEPEEADEDEGEIAIEKKAPPKTGGKPRKLTNQFNFCERAALTYNNPTRSQETQTTPPPMASFSANVLQWVIYDAYQADYAVQEQERERERREKMGLPPKIHVKKTPQQLTDEMQGRLFEATKVLERMINQNTYNEMAKDYKYWEDPSDEYREEEGTLLPLWKFTYNKTVKHTVTDLEWNPYYYDLFAVCFGYLDYTKPIADGCLCLFTIKNPSFPDYICMTESAVMCVDIHAKYPYMVVIGLYDGSVQVFNVQATCKEPAYKSNSVTNKHRGIVWEVKWAPDLPDGELNFFSVAGDGKINNWVLMQNDLSVTTITTLYLDQAPVPGPDGTMLKVKACASCVKIHPNKPQIYLVGTEEGLIFKCSVAYSSMYLLTYKAHQLPVYRIDFNRYNTDIFISCSSDWRVKVWEDNRLEPLFVFDVGDRVGDVKWAPYSSTVFACVTSEGKVCVYDLNVNKYKPICVQAIVSKKKNKITRLSFNYKSPIIVIGDDKGCVTTVKLSPNLRIPCKAPKKQQHLDQWTLQCMKLDRLLSLVREPVTLTIPPDTAGSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLY0</accession>
    <name>A0A6P7FLY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114331776</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137229.1">
        <property type="nucleotide sequence ID" value="XM_028281428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLY0"/>
    <dbReference type="FunCoup" id="A0A6P7FLY0">
        <property type="interactions" value="1887"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281428.2">
        <property type="protein sequence ID" value="XP_028137229.1"/>
        <property type="gene ID" value="LOC114331776"/>
    </dbReference>
    <dbReference type="GeneID" id="114331776"/>
    <dbReference type="KEGG" id="dvv:114331776"/>
    <dbReference type="CTD" id="26610"/>
    <dbReference type="InParanoid" id="A0A6P7FLY0"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003211">
        <property type="entry name" value="Elongator complex protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028137229.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40533" checksum="38DBEA1E8919F6B5" modified="2020-12-02" version="1">MEKKTLRSIPGTAYSAQNGHLLVSSGIPSLDTLLGGGIPVGTVVLIEEDFHGSYSKIVLKYFLAEGIVSNHSTLVASQDVNPSNIIKELPAVIDSDLEPERVLQSPGISDKMKIAFRYQNLPTRDSARHHVKHIGHIYDLSKNMSFSDIENSDICYWTGQRIENGSRTYSNPAYNALLKSISKKIKDGKFFLKDSPEKRTVLRIGVHSLGSPMWLPHRKSLHSIDSTRDLDKFIFCLRALVRSAYAVAVVTIPTHLYHEISLDRCIHSSDIAMRLQAFSGTELENNQSLAEYHGFFYLTKLAAINSLASRHPGSMEYGFKLRRKKFSIDVLHLPPDIQDNDSKRHNIPQLGCATGGGMKNLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMA4</accession>
    <name>A0A6P7FMA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114331887</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114331887</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137379.1">
        <property type="nucleotide sequence ID" value="XM_028281578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281578.2">
        <property type="protein sequence ID" value="XP_028137379.1"/>
        <property type="gene ID" value="LOC114331887"/>
    </dbReference>
    <dbReference type="GeneID" id="114331887"/>
    <dbReference type="KEGG" id="dvv:114331887"/>
    <dbReference type="InParanoid" id="A0A6P7FMA4"/>
    <dbReference type="OrthoDB" id="6628717at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028137379.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="32977" checksum="7E2E01835615B22A" modified="2020-12-02" version="1">MQKQRRELGLKRFWSAVKSSNSSSGSQCEPCPEDSPNEETKPPHCSLPLLQVWPSSDSPRGEADGQSFVFPVCAEDATSQNSTCMDNILHNDSGIDSDQVSPLPSTAGTSTTPLQSPTPSLRRPSSSLLHPDHARLLRLYPIISPPHSSTEDLSEINTNGGNPVVSPSSSTTSSLTSIAAAVAANNISRASDSSDSRRRSSTMTARYSIFDALDLEYALLRAAARGSVGPYSLSESLHKLTFTQSLAFPALARGLAGKRRRSQQNHARRPLNPNESGLNTCAKLVTALVLVLVSVLVFAVVYKFVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTL6</accession>
    <name>A0A6P7FTL6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PSME3-interacting protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114330884</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136105.1">
        <property type="nucleotide sequence ID" value="XM_028280304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTL6"/>
    <dbReference type="FunCoup" id="A0A6P7FTL6">
        <property type="interactions" value="1878"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280304.2">
        <property type="protein sequence ID" value="XP_028136105.1"/>
        <property type="gene ID" value="LOC114330884"/>
    </dbReference>
    <dbReference type="GeneID" id="114330884"/>
    <dbReference type="KEGG" id="dvv:114330884"/>
    <dbReference type="InParanoid" id="A0A6P7FTL6"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028136105.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34530" checksum="4304394061685B47" modified="2020-12-02" version="1">MSSGFITESEVIEIRKRRQEEWEKVRKADDPKERPEEPYDNRSLYEKLQEQKQKKDLEYEEAHKLKNMIKGLDDDEIEFLDLVDRTKTEADRKKEQEEEQELRDYRNRVSILQEKSIDERLQAEIVVNKTKREKQPNSQQKLLKGVVIKKPENQKRKIDEVDNSEETNVKKQKNPENQKKKIDEVDNSDETNVKKQKKPENQKRKIDEIDNSEETNVKEQAIIDVDDKSTKNTQTPVAEEASNTGLKCVAILPGIGCYQDSSSDNDDSSDSDDEPSPCRQIDLLGRKIVIKQAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYJ2</accession>
    <name>A0A6P7FYJ2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fork head domain-containing protein FD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114334076</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139892.1">
        <property type="nucleotide sequence ID" value="XM_028284091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYJ2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284091.2">
        <property type="protein sequence ID" value="XP_028139892.1"/>
        <property type="gene ID" value="LOC114334076"/>
    </dbReference>
    <dbReference type="GeneID" id="114334076"/>
    <dbReference type="KEGG" id="dvv:114334076"/>
    <dbReference type="CTD" id="43843"/>
    <dbReference type="InParanoid" id="A0A6P7FYJ2"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20035">
        <property type="entry name" value="FH_FOXQ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000352">
        <property type="entry name" value="Forkhead box Q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047519">
        <property type="entry name" value="FH_FOXQ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028139892.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33064" checksum="B59077D14867D596" modified="2020-12-02" version="1">MCNNENSTNYPSQSKLPIRFTFDANFPRALFPIDHYKLQLYQYAVAERLRYPLLNPFPSALTCYPLLPRSLQPEEPKPQHSYIGLIAMAILSSPDSKLVLSDIYQHILDNYPYFRTRGPGWRNSIRHNLSLNDCFIKAGRSANGKGHYWAIHPANVEDFRKGDFRRRKAQRKVRKHMGLAVDEDGADSPSPPPLLESPSVVPGPSTSVYPIVSTRNSTRKRQFDVESLLAPDSGEETNEEDIDVVTSDNQEKSEEKQQWPMFPIVDYYQALLNTTSIRPVLPESNVNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYW7</accession>
    <name>A0A6P7FYW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FMC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334169</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140007.1">
        <property type="nucleotide sequence ID" value="XM_028284206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYW7"/>
    <dbReference type="FunCoup" id="A0A6P7FYW7">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651245.1">
        <property type="protein sequence ID" value="XP_050507202.1"/>
        <property type="gene ID" value="LOC126884911"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651246.1">
        <property type="protein sequence ID" value="XP_050507203.1"/>
        <property type="gene ID" value="LOC126884911"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FYW7"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20271">
        <property type="entry name" value="Complex1_LYR_FMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037667">
        <property type="entry name" value="FMC1_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716:SF1">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140007.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11964" checksum="739CE6653FC0D258" modified="2020-12-02" version="1">MVSKICTIRQIISELRYALPEGNLKNNLMLQYVISQFRKYKTTDEQLCKARQEMDFMAKTYLCYLKSTRLSDEIHQEYHGKGERTVADTANMVGFKLPHDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G340</accession>
    <name>A0A6P7G340_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase PP2A regulatory subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC114337178</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143378.1">
        <property type="nucleotide sequence ID" value="XM_028287577.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143379.1">
        <property type="nucleotide sequence ID" value="XM_028287578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G340"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287577.2">
        <property type="protein sequence ID" value="XP_028143378.1"/>
        <property type="gene ID" value="LOC114337178"/>
    </dbReference>
    <dbReference type="GeneID" id="114337178"/>
    <dbReference type="KEGG" id="dvv:114337178"/>
    <dbReference type="CTD" id="2768940"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="235"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028143378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028143379.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="67005" checksum="71F15C54F33468AF" modified="2020-12-02" version="1">MAASDSAGDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGVERTRTELIPFLTETIYDEDEVLLALAEQLGTFINLVGGSEYAYCLLPPLESLATVEETVVRDKAVESLRAVAQQHSPADLETHFVPLVQRLAAGDWFTTRTSACGLFSVCYPRVSALVKGELRAHFRALCQDDTPMVRRAAATKLGELAQVVELEYLKSDLIPMFVNLAQDEQDSVRLLAVEACVSIATLLQQEDVEQLVMPTLRQCTGDTSWRVRYMVAERFTELQKAVGPEITRTDLVNAFQSLLKDTEAEVRAAAANKVKDFCQNLDKAHQENIIMTNILPCVKELVADPNQHVKSALASVIMGLSPILGRHNTIEHLLPLFLTQLKDECPEVRLNIISNLDCVNEVIGIQQLSQSLLPAIVELAEDSKWRVRSAIIEYMPLLAGQLGREFFDEKLNALCMTWLMDHVFAIREAATLNLRKLVDQFGAEWAESTIIPKVLAMSRDPNYLYRMTCLFCINVLAEACGSDITTKVLLPTVLSMANDKVANVRFNVAKTLQRIAPQLDQSVIQPQVKPVLDKLNVDTDVDVKYSASEAIMGIAVQTRLHKSRIQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3T3</accession>
    <name>A0A6P7G3T3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114335618</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114335618</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141682.1">
        <property type="nucleotide sequence ID" value="XM_028285881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3T3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285881.2">
        <property type="protein sequence ID" value="XP_028141682.1"/>
        <property type="gene ID" value="LOC114335618"/>
    </dbReference>
    <dbReference type="GeneID" id="114335618"/>
    <dbReference type="KEGG" id="dvv:114335618"/>
    <dbReference type="InParanoid" id="A0A6P7G3T3"/>
    <dbReference type="OrthoDB" id="6612236at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028035671" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028141682.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="13758" checksum="81A8FD2801A3DFEE" modified="2020-12-02" version="1">MSITNYIVILASILIASTAAQRGFYAGSSPKGIPGVAARFRPGGSLYNPPQDVGTSSRFGDSRFGAGLNRGNQGPVSFTGNQGVASSFGAGNSISGPVVTGRFFNIIIHNQWRTYVYDPFADAWYPKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3V0</accession>
    <name>A0A6P7G3V0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114333556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114333556</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139245.1">
        <property type="nucleotide sequence ID" value="XM_028283444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3V0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283444.2">
        <property type="protein sequence ID" value="XP_028139245.1"/>
        <property type="gene ID" value="LOC114333556"/>
    </dbReference>
    <dbReference type="GeneID" id="114333556"/>
    <dbReference type="KEGG" id="dvv:114333556"/>
    <dbReference type="InParanoid" id="A0A6P7G3V0"/>
    <dbReference type="OrthoDB" id="6419576at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028320545" evidence="1">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028139245.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29951" checksum="671E6DBCFAD08E14" modified="2020-12-02" version="1">MKSFVIFLFFVAISAAQVQKETKNTEIYERFVKIAVEKLIKSLEAQSSDPGIIAQLNEYAQKLLSSLAKYAVNHDLEPIAIADVAEDFLLANFKLTKGELRGISTIERYDDVYVAYKHTTKTLSLVIPIEFLDLTFMYNYEIHVLGMGPKGEMTADIKKFKFYLSFDFDIPNLKASINTLKVEDCGQISVTVDGNPGDFIFNLISQFVTTILHPLIQGIIEGIIKSVASQVVDDINEMLYNMTHPTNSTVNQISSQFSQYVLDYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6A6</accession>
    <name>A0A6P7G6A6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein N-terminal asparagine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114334214</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140050.1">
        <property type="nucleotide sequence ID" value="XM_028284249.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508661.1">
        <property type="nucleotide sequence ID" value="XM_050652704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6A6"/>
    <dbReference type="FunCoup" id="A0A6P7G6A6">
        <property type="interactions" value="1490"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284249.2">
        <property type="protein sequence ID" value="XP_028140050.1"/>
        <property type="gene ID" value="LOC114334214"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652704.1">
        <property type="protein sequence ID" value="XP_050508661.1"/>
        <property type="gene ID" value="LOC114334214"/>
    </dbReference>
    <dbReference type="GeneID" id="114334214"/>
    <dbReference type="KEGG" id="dvv:114334214"/>
    <dbReference type="CTD" id="123803"/>
    <dbReference type="InParanoid" id="A0A6P7G6A6"/>
    <dbReference type="OrthoDB" id="539995at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028140050.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34603" checksum="7A4FC61B74F5DF15" modified="2020-12-02" version="1">MVLVLNGVLQEDCPPDSRSLYHTHPIYGETAAQLLGVPNKIIGSVGLLYVQQRELAATVPHDKNVNILGADDVTTCLIVVVRHSGSGAVAMAHLDGSGTDEAVCTMVQRVQELALGYPEGRIELQLIGGFNDPRHYSDEIFYNVLNSFHKHPIEIDLTLACTGELNTTIRGGIHWPIIYGVGVNTKTGEIFPATFPDKGPDHSLRSARYLTGVPQVLDIYDCALGLLRIGPFNYEPLRGVDLWLEQSDDFILQHLSTSPEVQPPHFVMQVRATLKYIQENQFPAVTVFRDNRPHYFRRDEHSGIWIPLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7N5</accession>
    <name>A0A6P7G7N5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein YJR142W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334650</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140540.1">
        <property type="nucleotide sequence ID" value="XM_028284739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7N5"/>
    <dbReference type="FunCoup" id="A0A6P7G7N5">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284739.2">
        <property type="protein sequence ID" value="XP_028140540.1"/>
        <property type="gene ID" value="LOC114334650"/>
    </dbReference>
    <dbReference type="GeneID" id="114334650"/>
    <dbReference type="KEGG" id="dvv:114334650"/>
    <dbReference type="InParanoid" id="A0A6P7G7N5"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028140540.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37086" checksum="F24DB82F896D0E00" modified="2020-12-02" version="1">MSLGEKTEMSRLYKLAQKFNCFYLTGLKSTECKPFFVEGYQVGLVRPDVMKQLIRYPEVFLVSSGCVELNPAFRDYEERSGHVERVLKELRAENVFIALKGWRDECYEVKTDFTSKSLLKMDRAATCLFGIRNYGVDINGYVRHPVLGLCLWFQKRSSTKQTWPGKWDNMVGGGLSVGHGILETAHKEAMEEASVPVELLKNLISAGCVSFFFESDRGLFPNTEFIFDLELPVDFVPVNADGEVETFELLTANQCLEKILTADFKTTSAPVALDFLIRHGIVTPENDNDYLKVVELLHVPLQSIYSTYLRSMHIKENGTSVHHSNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9R7</accession>
    <name>A0A6P7G9R7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114335230</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028141230.1">
        <property type="nucleotide sequence ID" value="XM_028285429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9R7"/>
    <dbReference type="FunCoup" id="A0A6P7G9R7">
        <property type="interactions" value="1173"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285429.2">
        <property type="protein sequence ID" value="XP_028141230.1"/>
        <property type="gene ID" value="LOC114335230"/>
    </dbReference>
    <dbReference type="GeneID" id="114335230"/>
    <dbReference type="KEGG" id="dvv:114335230"/>
    <dbReference type="CTD" id="4351"/>
    <dbReference type="InParanoid" id="A0A6P7G9R7"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000030">
        <property type="entry name" value="Mannose-6-phosphate isomerase ManA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028141230.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45203" checksum="0B0DA41B37CB217B" modified="2020-12-02" version="1">MELVCEVQKYDWGKRGQESKVAQLIRSANEHFQIEESSPYAELWMGTHVNGPSLVKETGQLLSKYISEHPSVLGEKVAAKFNKQLPFLFKVLSINNALSIQAHPTKEFAEALHRKYPDIYKDPNHKPEMAIALTPFEALCGFRPPQEVRHFIEQLPELENITKSKNEMDDKKFLEKSFRSILTCDKQLISSTIKSLQTKFKELSSCDQTKYHVSLFDRLNCQFPNDNGVLMVYFLNYIKLKPSEAIFLAANEPHAYIYGDCIEVMASSDNVVRAGLTPKFVDVETLLSMLEYKGDIAEEKLFKPVNEDEYTRLFRPPVPDFAVVEIRIPNSVKLYRTIKRDSASIIIIMEGTGKSKNREIKPGLVLFLAADETFEISEISSYTEYLLMYQAFANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9S3</accession>
    <name>A0A6P7G9S3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-binding cassette sub-family F member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114339529</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145986.1">
        <property type="nucleotide sequence ID" value="XM_028290185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510424.1">
        <property type="nucleotide sequence ID" value="XM_050654467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9S3"/>
    <dbReference type="FunCoup" id="A0A6P7G9S3">
        <property type="interactions" value="1646"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654467.1">
        <property type="protein sequence ID" value="XP_050510424.1"/>
        <property type="gene ID" value="LOC114339529"/>
    </dbReference>
    <dbReference type="GeneID" id="114339529"/>
    <dbReference type="KEGG" id="dvv:114339529"/>
    <dbReference type="InParanoid" id="A0A6P7G9S3"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000467">
        <property type="entry name" value="ATP-binding cassette sub-family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="90"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="402"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028145986.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="70773" checksum="79EABBAF4212473E" modified="2020-12-02" version="1">MPSDAKKREQQRKKDAAKARQAGKKNEKQKGEEQNDTLKTNGLSNGATNGSSELSAEEALCAKLEADARLNAEARACTGSLAVHPKSRDVKIDTFSITFHGCEMLQDALLELNCGRRYGLLGLNGSGKSTILAVLGNREVPIPDHIDIFHLTREMPASDKTALECVMEVDEERVRLEKLAEELVACEDDESQEQLMDIYERLDDMAADTAEARAANILHGLGFTREMQNKKTKDFSGGWRMRIALARALYVKPHLLLLDEPTNHLDLDACVWLEEELRNYKRILVLISHSQDFLNGVCTNIIHINKKRLKYYTGNYDAFVKTRMELLENQMKQYNWEQDQINHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVTSDKIVTFYFPSCGTIPPPVIMVQNVSFRYNDSTPLIYKNLEFGIDLDTRLALVGPNGAGKSTLLKLLYGDLTPTEGMIRKNSHLRIARYHQHLHELLDLDLSPLEYMMKEFPDIKEKEEMRKIIGRYGLTGRQQVCPIRQLSDGQRCRVVFAWLAWQVPHMLLLDEPTNHLDMETIDALADAINEFEGGMVLVSHDFRLISQVAEEIWVCEKGTVTKWQGDILSYKDHLKTKILKDAAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GA82</accession>
    <name>A0A6P7GA82_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CCR4-NOT transcription complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CCR4-associated factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC114335665</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2. Interacts with EBF1. Interacts in an RNA-independent manner with BICC1 (via KH domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141738.1">
        <property type="nucleotide sequence ID" value="XM_028285937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GA82"/>
    <dbReference type="FunCoup" id="A0A6P7GA82">
        <property type="interactions" value="1398"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285937.2">
        <property type="protein sequence ID" value="XP_028141738.1"/>
        <property type="gene ID" value="LOC114335665"/>
    </dbReference>
    <dbReference type="GeneID" id="114335665"/>
    <dbReference type="KEGG" id="dvv:114335665"/>
    <dbReference type="CTD" id="35501"/>
    <dbReference type="InParanoid" id="A0A6P7GA82"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="19">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="20">
        <location>
            <begin position="615"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="132"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_028141738.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="82682" checksum="C85D9D1872F0F256" modified="2020-12-02" version="1">MAATRKLQGEIDRCLKKVTEGVDTFEDIWQKVHNATNSNQKEKYEADLKKEIKKLQRLRDQIKSWIASAEIKDKSILMDNRKLIETQMERFKVVERETKTKAYSKEGLGAAQKLDPAQKERDDIQYWLTSSIAKLNIGSDSLESEIEQLLSNKKKKLDKDKQDRIEDLKSRLDKHKFHIRKLETLLRMLDNMSVEVQQIKNIRDNVEYYIDFNTEPDFEDNEFIYDDIIGMDEVELSGVALPSSATTDSNETGGTPTSIISGSSPPPSSSPPLQPPTSSVPLTMTSLATAAAAAAANSVLHNYNNHSGENSNDDSKKVVGKEQKVCYTSFLQPIKPMPVRAVTNSQSTTNTPLNSLLNYSSVGSIGAVTSSLPPPSAINPIGVTLAPSVGKTTVSLANSVVGGIVTPVGNAVGNKIQPGREASPVSLVQSLTTSSMGGNFAAVAAASAAKTTTASGESNPASVITIVSQVQTQNTSNAINTTVHTNPIASLGLQNSTNPPPKLYNEQHVQNNCISPEPNNGSEMSTSDVDVSQQVPNGTTTEKISEGMTSLKSMAQQVIDQAGLQNNQVILEPSKLQNQGKSDAHIPPLLGVAPLGAIPLQKEHQTQFQLMEAAYYHMPHPSDSERIRTYLPRSPCTTPSYYIQTPLAHSESLDFFQRLATETLFFVFYYMEGTKAQYLAAKALKKQSWRFHTKYMMWFQRHEEPKIINEEYEQGTYIYFDYEKWGQRKKEGFTFEYKYLEDRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF43</accession>
    <name>A0A6P7GF43_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450 9e2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114341623</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148234.1">
        <property type="nucleotide sequence ID" value="XM_028292433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF43"/>
    <dbReference type="FunCoup" id="A0A6P7GF43">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641988.1">
        <property type="protein sequence ID" value="XP_050497945.1"/>
        <property type="gene ID" value="LOC126879075"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641989.1">
        <property type="protein sequence ID" value="XP_050497946.1"/>
        <property type="gene ID" value="LOC126879075"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641990.1">
        <property type="protein sequence ID" value="XP_050497947.1"/>
        <property type="gene ID" value="LOC126879075"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GF43"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028148234.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="59853" checksum="C54CC080CBF53106" modified="2020-12-02" version="1">MLIPVLLIICISLLYYYVTWLQNYWTRRKVPQGDTVWLFGDLFWFILRRESTAAWVKRVYDIFPNTRYSGSYQFTTPTLIIKDVDLIKKIAIKDFDTFPDHRTYVPETSDPLWAKNLFAVKVPKWRQMRPVLSPAFTSSKMKLMFNLMIDCVDHFVGHFKNGNNEVVEVECTDVFSRFATDVIGSCAFGFEVNSVKEANNEFYQKGLELTDFTNFWKNFALFGYMIIPGLYKLLNLKIVSDEESKYYHSIIEKTIKLRKEKGIIRHDMIHLLMEARDEANKLQTNGDHNDWNISDEDIIAQAIVFYFAGFDTITLLLTYLFYELALNPDIQNKLRNEVEQTLKECDGKVTYEALFKMKYMDMAVSETLRKYPINVIVDRVCTKPYIIEPTAAHESPISLEVGTVVWIPIYPIHHDPKYYPEPEKFDPERFNEDNKSTIVPGSYIPFGIGPRNCIGSRFALMETKILCFYILHHFEIVPTKKTMIPVSLSPKTFNMKPDKSIWLGLKRRNESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGY0</accession>
    <name>A0A6P7GGY0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Epidermal growth factor receptor kinase substrate 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114337973</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144358.1">
        <property type="nucleotide sequence ID" value="XM_028288557.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497212.1">
        <property type="nucleotide sequence ID" value="XM_050641255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGY0"/>
    <dbReference type="FunCoup" id="A0A6P7GGY0">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288557.2">
        <property type="protein sequence ID" value="XP_028144358.1"/>
        <property type="gene ID" value="LOC114337973"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641255.1">
        <property type="protein sequence ID" value="XP_050497212.1"/>
        <property type="gene ID" value="LOC114337973"/>
    </dbReference>
    <dbReference type="GeneID" id="114337973"/>
    <dbReference type="KEGG" id="dvv:114337973"/>
    <dbReference type="InParanoid" id="A0A6P7GGY0"/>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000289">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000183">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="469"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028144358.1"/>
        </source>
    </evidence>
    <sequence length="738" mass="84795" checksum="31CBD50366591E9B" modified="2020-12-02" version="1">MAYRNGYSGDDRELDREDRMTEGVGKPVHVIEHLATFTVNKETGIIYPADGMRRLLQLEKSNGIWSQKMQLCLDNNWVLIMDYETGSVMERFPASSIQEPSAFMSQDPMDMYNNILVFIVTNSNQSHPTEMHIFQCQSISAQDLVEDLKELRMGKAPTRSRKSSIPPPSHKPPQNVISPSRDVTRDYYGSDSELTANNDDSSSTTSEKYERDVTILNHCFDDIEKFIARLQHAAAAARELERRRKTRKTKKRDMGDGMLTMRTKPPPEKEFVDIFQKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEAAHDQYFDQHIPHNVISPLLTREAVNLLMNCVTSKETELWHSLGSAWLIPRDQYKGNVMTYHPVFMDGWSPEYPVIDETEPKSYQHDQYGGDYTDYPSSSQDVYDRNNHHQPDKDIAALGESTRSDISIDSIERNGGEERGFGRNQESFLEDLQNRGATIVQVTYPRTANNEKELTVVRGEYLEILDDSRKWWKARNSRGQIAHVPHTIVTPYIFNNPLHATQNYRRNDSPVERFNRDHSNQDHSPQSKSTTDWIRNERTEVQNTPPPPPPPPPAPEPPSQPVTPQPLKRTQSRQSLMSTKSNGDLQEELISVLTLVREKNKQRHLEIKQTPETFIDQRSNPIEVQEWLEAKGFSENIRNKFQGVSGHQIFDFNKSELERVCGKDEGKRLTSQLNIQKATSGYQTVRSTELRKILAKVRQKMGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHB9</accession>
    <name>A0A6P7GHB9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114338154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114338154</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144538.1">
        <property type="nucleotide sequence ID" value="XM_028288737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHB9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288737.2">
        <property type="protein sequence ID" value="XP_028144538.1"/>
        <property type="gene ID" value="LOC114338154"/>
    </dbReference>
    <dbReference type="GeneID" id="114338154"/>
    <dbReference type="KEGG" id="dvv:114338154"/>
    <dbReference type="InParanoid" id="A0A6P7GHB9"/>
    <dbReference type="OrthoDB" id="7659889at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028144538.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19806" checksum="ED1442D93BDB312D" modified="2020-12-02" version="1">MEFKKRTVHLKIKYFDSSEETPEIVKKTIEILPHTDGTILKSELYKICNVNKEKVMKIRNGEGALVPISFLADPNVPDRYFQIDITNISYVDRPTANLLQDAYVDAVQQKIRTLESRIAQSELLLPQLEWRRQAYMEDTVNGLMYKVGFLNRRFDELLPQFTAKHPETMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIN1</accession>
    <name>A0A6P7GIN1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-related protein Rab-8A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114343165</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149776.1">
        <property type="nucleotide sequence ID" value="XM_028293975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIN1"/>
    <dbReference type="FunCoup" id="A0A6P7GIN1">
        <property type="interactions" value="1911"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648546.1">
        <property type="protein sequence ID" value="XP_050504503.1"/>
        <property type="gene ID" value="LOC126883250"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIN1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028149776.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23681" checksum="4119DF94979028A4" modified="2020-12-02" version="1">MAKSYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNTTFISTIGIDFKIRTIDLDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFENIKNWIRNIEENASADVEKMLLGNKCELKDKRQVSKEKGEQLAVEYGIKFIETSAKASIRVEEAFFTLARDIKTKMEKKLEASNPPRGHQLKATEPPKKPTSWLSRCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJ54</accession>
    <name>A0A6P7GJ54_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Facilitated trehalose transporter Tret1-2 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114337531</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143795.1">
        <property type="nucleotide sequence ID" value="XM_028287994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJ54"/>
    <dbReference type="FunCoup" id="A0A6P7GJ54">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287994.2">
        <property type="protein sequence ID" value="XP_028143795.1"/>
        <property type="gene ID" value="LOC114337531"/>
    </dbReference>
    <dbReference type="GeneID" id="114337531"/>
    <dbReference type="KEGG" id="dvv:114337531"/>
    <dbReference type="InParanoid" id="A0A6P7GJ54"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="77"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028143795.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="59212" checksum="7BE588A03B6180EF" modified="2020-12-02" version="1">MRNNKKVQKSFCSVKALSNNKHHSLGHSSFYRAVKNEPTYFLIESVELKSLFRSVGDLQDYLQKNKMADSGQAKTFPQYIAALSVCLGAVAAGAVLGWTSNISKDLQKGGLNDLVISDDQLGWIGSFVTLGALLMCFPIGYICDLIGRKWGCLLTLIPFTVGWLLVIFSSSVSVIYVGRFLTGLAGGSFCVAAPIYTAEIAQASIRGALGSYFQLLLTVGILIVYVGGAWMHPKDLAILSAVIPIVFAVVFFFQPETPIYLMKKNRPEEAKKALQRLRGNAYDCDAELKEIQLSFEQGSSEKSFMTVLKTKAAIKACLITFSLMFFQQMSGINAVIFYTGKIFEASGSSLDPAVGTIIVGILQTSATFGSSLIVDKFGRKILLLISIAFMGLSEFVLGLFFTFKERSVLDDDQLKAIGFLPIICLGIYIVMFSVGFGPIPWMISAELMPEEVKSTMVSAAATFNWFLAFIVTKFYVNLKTSIGGDVTFYIFSGICIGGAAFVLFCVPETKGKSVAEVQALLSGDKTAPVSNEKEGIDNPTFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLK6</accession>
    <name>A0A6P7GLK6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transforming growth factor beta regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114343911</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028150554.1">
        <property type="nucleotide sequence ID" value="XM_028294753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GLK6"/>
    <dbReference type="FunCoup" id="A0A6P7GLK6">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294753.1">
        <property type="protein sequence ID" value="XP_028150554.1"/>
        <property type="gene ID" value="LOC114343911"/>
    </dbReference>
    <dbReference type="GeneID" id="114343911"/>
    <dbReference type="KEGG" id="dvv:114343911"/>
    <dbReference type="InParanoid" id="A0A6P7GLK6"/>
    <dbReference type="OrthoDB" id="285793at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028150554.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="40199" checksum="9B61EBA037AFB615" modified="2020-12-02" version="1">MEYDYSNSNFNNSNFMQRNNFQRPTGKYKQKLMVLKRNIREFVHENAALVDELEEIQMNIIIKKEERKFLLKKLCEYEPQVALEVQNAAKDGPVSRPSVTHVSSNTNNSVSEKKSKKKVHMSSSDRRSSSSLKSRKSSSKGRKKIIQPVPVDHNGKPIFPIELGRLTVHSLGEVVHTRSEFHTENAIYPVGYVSTRVYGSLKDPTQKCVYTCKISDANDIPRFEIASDDHRPPITGDTPDVCHSLLLQSINDSLSLNVVSTRPRGHDFFGLSHPTVLHLIQSYPGVRRCANYKWIKFEVSKNCDMYTDDNDAGLSYEYLQRSINFCKYKMAPDVLQRPDDFLDSKDNLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNK3</accession>
    <name>A0A6P7GNK3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein enhancer of sevenless 2B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114340999</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147582.1">
        <property type="nucleotide sequence ID" value="XM_028291781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNK3"/>
    <dbReference type="FunCoup" id="A0A6P7GNK3">
        <property type="interactions" value="1729"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653920.1">
        <property type="protein sequence ID" value="XP_050509877.1"/>
        <property type="gene ID" value="LOC126886838"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNK3"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09941">
        <property type="entry name" value="SH2_Grb2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11804">
        <property type="entry name" value="SH3_GRB2_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000022">
        <property type="entry name" value="Growth factor receptor-bound protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028147582.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="25620" checksum="29C32396F9374D50" modified="2020-12-02" version="1">MEAIAKHEFNATADDELSFRKAQVLKILNMEDDMNWYRAELDGREGLIPSNYIEMKPHEWYYGRITRADAEKLLLNKHEGAFLIRISESSPGDFSLSVKCSDGVQHFKVLRDATGKFFLWVVKFNSLNELVEYHRTSSVSRSQDVKLRDMVAEEVSFMMSGGEEYLVQALYDFTPQEVGELEFRRGDVITVTDRSDQHWWHGEIGHRKGLFPATYVTPYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPM4</accession>
    <name>A0A6P7GPM4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114344925</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028151548.1">
        <property type="nucleotide sequence ID" value="XM_028295747.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028151549.1">
        <property type="nucleotide sequence ID" value="XM_028295748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050658550.1">
        <property type="protein sequence ID" value="XP_050514507.1"/>
        <property type="gene ID" value="LOC126889865"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028151548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028151549.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38264" checksum="2FAC4B7382AC8460" modified="2020-12-02" version="1">MVLNPRESAKLIASKALMVKINEYGIEKLGDILVEEIESGKLSPSNFSQTDVHPKSTDKNAIDWIFVVDTLNFCFWHYKWEEGWVVNGLTGYFALCGAINRAVKQGIDILNPKFYSTITKEKLAEILKSDNKVEIPLFDERLKCLHEVGNVLLEKFDGSFENVVKKANHSAKTLLNLVVENFQCFKDEADYNGQRVSLYKRAQILVGDIWACFENKDLGYFEDIEEITAFADYRVPQTLLWYGALEYQEDLQAYLDDNVIFKNGDDEEIEIRGCTIHAVELLKEYVAKKLSTNKTINSILIDHFLWDFRRKHAKEIEEKGLPFHKTFSIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GST2</accession>
    <name>A0A6P7GST2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114340325</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146870.1">
        <property type="nucleotide sequence ID" value="XM_028291069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GST2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291069.2">
        <property type="protein sequence ID" value="XP_028146870.1"/>
        <property type="gene ID" value="LOC114340325"/>
    </dbReference>
    <dbReference type="GeneID" id="114340325"/>
    <dbReference type="KEGG" id="dvv:114340325"/>
    <dbReference type="InParanoid" id="A0A6P7GST2"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028146870.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="30581" checksum="3181C2E653F3C085" modified="2020-12-02" version="1">MAQQYKSLHPVKYYRDYLAHEIRPDGREFNKFRPILLNVGTIDTADGSAIAKVGNTTVVCGIKAELCKPKADAPDKGFLVPNLELTPLCSSKFRPGPPSDQAQVLTQLIAEIIDNSKCINLKDLCICNDKLAWCLYVDFVCLDFDGSVVDTCLVSFLGAIKSITLPFIDYDPALDNIQVNLEERKHIEIYNTPVSTTFAVFDDKVILKDPTLEEESLCSGILTIVFKDEELCCVHKPGGSALTQEELQQCITESKERTPLIKSLIETAVKDYVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVL8</accession>
    <name>A0A6P7GVL8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Drosomycin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114347258</name>
        <name evidence="8" type="synonym">LOC114347236</name>
        <name evidence="9" type="synonym">LOC114347247</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153766.1">
        <property type="nucleotide sequence ID" value="XM_028297965.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153775.1">
        <property type="nucleotide sequence ID" value="XM_028297974.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028153786.1">
        <property type="nucleotide sequence ID" value="XM_028297985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVL8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028297965.2">
        <property type="protein sequence ID" value="XP_028153766.1"/>
        <property type="gene ID" value="LOC114347236"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297974.2">
        <property type="protein sequence ID" value="XP_028153775.1"/>
        <property type="gene ID" value="LOC114347247"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297985.2">
        <property type="protein sequence ID" value="XP_028153786.1"/>
        <property type="gene ID" value="LOC114347258"/>
    </dbReference>
    <dbReference type="GeneID" id="114347258"/>
    <dbReference type="KEGG" id="dvv:114347236"/>
    <dbReference type="KEGG" id="dvv:114347247"/>
    <dbReference type="KEGG" id="dvv:114347258"/>
    <dbReference type="OrthoDB" id="7800919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.10:FF:000001">
        <property type="entry name" value="Drosomycin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00304">
        <property type="entry name" value="Gamma-thionin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00505">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044651046" evidence="4">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028153766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028153775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028153786.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7284" checksum="FE719DB667D861AE" modified="2020-12-02" version="1">MKIFYIFAIVFFVALSTKTALGDCLSGRFGGPCAVWDNETCRRVCKEEGRPSGHCSPSLKCWCEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GX67</accession>
    <name>A0A6P7GX67_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114343395</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150013.1">
        <property type="nucleotide sequence ID" value="XM_028294212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GX67"/>
    <dbReference type="FunCoup" id="A0A6P7GX67">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647156.1">
        <property type="protein sequence ID" value="XP_050503113.1"/>
        <property type="gene ID" value="LOC126882293"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GX67"/>
    <dbReference type="OrthoDB" id="7677057at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF40">
        <property type="entry name" value="ODORANT RECEPTOR 56A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028150013.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="48463" checksum="E072DF55AC2F8CFE" modified="2020-12-02" version="1">MARKSIFPKCEHMKLSMYANAVFGIWPFIFEDYPTLKKIYDVYCKITLTYYFLFIVSGWIKFFQLFQEVPIPATEIMGNISITFIYSVTIWRARAIRGPRMMNIIKNVIDWEKKIMESEDQPLIDIFNNYAWQNRIISQVFIITVIIVTNLFFVHPLGLDPRPRYDPVTNETVYIKPLPLSSWFPFDDQKHYLRAYMFHILDAYVGASFVNNTDLFSFGIITFPLGQTVILNYILSHFEDYVVKIQEQLGVERDEASFITLRECILKHKDIISYIKAFNKEMNIVILLDFLQSSLQLAAIALQLIFFEVNLFNFVFSIMFVICMLTRLLGYYWYANEIIIETSNIPLAIWSSKWYEEPKKTQDMMMIMMLKCSRPLTLNIGPFNTMSINTLIGIIKATYSYMMVVYKGQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H421</accession>
    <name>A0A6P7H421_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114344097</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114344097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150755.1">
        <property type="nucleotide sequence ID" value="XM_028294954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H421"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294954.2">
        <property type="protein sequence ID" value="XP_028150755.1"/>
        <property type="gene ID" value="LOC114344097"/>
    </dbReference>
    <dbReference type="GeneID" id="114344097"/>
    <dbReference type="KEGG" id="dvv:114344097"/>
    <dbReference type="InParanoid" id="A0A6P7H421"/>
    <dbReference type="OrthoDB" id="7696867at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028150755.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34651" checksum="6D8A0D6DFA899733" modified="2020-12-02" version="1">MSNVINFNSNNTFNTVSTNAQEQEVNDRMEFLKLEQSKYLQQKILYDLLEDVVYDDHTDAKLKSKVKDIILSENLKQTLSIDNKSLEENESNVLGVAQDITVLTYSESSLLRNLIKLKSTKKVEDLAAQHNEWTELLESIRELGSIQLSQEDKILLEYKNKVIVEQEKYINNLLNLHKLLEEITHTRTVDLPKTMEQKIAECQVEEKINYLKCIIVQEKCRAEIFTETKCSLRAYRELIKDIQLQQRDCRKDIEDLSELKQKYKAIAGKQYDDILKSYILYKGALEKKKMLCSSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H4W2</accession>
    <name>A0A6P7H4W2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp90 co-chaperone Cdc37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114346125</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152713.1">
        <property type="nucleotide sequence ID" value="XM_028296912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H4W2"/>
    <dbReference type="FunCoup" id="A0A6P7H4W2">
        <property type="interactions" value="1990"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657895.1">
        <property type="protein sequence ID" value="XP_050513852.1"/>
        <property type="gene ID" value="LOC126889543"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H4W2"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="10">
        <location>
            <begin position="118"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="9">
        <location>
            <begin position="286"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028152713.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43543" checksum="AEF673D5EA892C53" modified="2020-12-02" version="1">MVDYSKWKNIEISDDEDETHPNIDTPSLFRWRHQARVERMEERKHEFENLDKRKTEHSKKANELKEKLKEAEKTNAANLAELKKSFQELEIQGESLKKEEEEMRKKDKLTPWNVDTISKPGFAKTVINTKPARAKEENLTEAEKEARLNKFIKEHEKDLKHYGMLRKYDDSRAYLKSHNELVCEDTANYLVVWCINLEMDKKHDLMNHVAHQIICMQYILELAKQLDCDPRACVDAFFAKIQVAEVEYKQSFDDELRQFKERIRKRAAEKLEEAIKEVEEEERQKRLGPGGLDPLEVFETLPDELKACFESQDIQLLQDTIAKMDEDQAKYHMKRCVDSGLWVPDAGKKSAEEKGAEEGDAAQEKEVDEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9B3</accession>
    <name>A0ABM5I9B3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127896.2">
        <property type="nucleotide sequence ID" value="XM_028272095.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050651403.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272095.2">
        <property type="protein sequence ID" value="XP_028127896.2"/>
        <property type="gene ID" value="LOC114324292"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651403.1">
        <property type="protein sequence ID" value="XP_050507360.1"/>
        <property type="gene ID" value="LOC114324292"/>
    </dbReference>
    <dbReference type="GeneID" id="114324292"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF2">
        <property type="entry name" value="AGAP003037-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028297" evidence="3">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127896.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="530" mass="60296" checksum="4A8F8BD12E3012BE" modified="2025-10-08" version="1">MRIFIALISLLICGDIFISQTEARRVRIQQPDEEEEQETVSYYAAEPQEERGQVVLVSSADRYNGLYGQQAASSRSIDNNYIPRGSARANEGRTKARDEVKAPPVQTIRNYNKVNDDGSFTFGYEAADGSFKEETRGTDCVVRGKYGYVDPDGNKREFTYVSGNPCDPNAPKEEEEAENEADNENIPANYPSRPIQPQYRRPPVTAAPKPAVTLFQTNYAQEEEEPEPEQLLRVTPQPQPVRRPTYISRPQYVPQTTPTVEERPNYRQQVLSSTTPSSVIYRTSAHPISITPRPVTTTTKRPQLPATTYRPQLLQVSVTPRPNSLLYSKQLQSTLQPTAFPEKNDFESEFHRFQQENNIVSPTPTPFTVKPTTPKPKPAGNPGQVYSTALVYDPSTGQYNNQIYQALPQSDGDFLLKQRIQPYVQRPRPQVLNIQQLQQQSPLYSQNLRPQPIPQAAYQAQQSELQFQNSAQLYAQQQHAREQQREQQRHQQQVRPQQQQVYYLQPSVDQQGGLAASQIDAFLRGHNIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IC16</accession>
    <name>A0ABM5IC16_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="RefSeq" id="XP_028129522.2">
        <property type="nucleotide sequence ID" value="XM_028273721.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273721.2">
        <property type="protein sequence ID" value="XP_028129522.2"/>
        <property type="gene ID" value="LOC114325618"/>
    </dbReference>
    <dbReference type="GeneID" id="114325618"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046768680" description="tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]" evidence="15">
        <location>
            <begin position="17"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="16">
        <location>
            <begin position="52"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="387"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129522.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="502" mass="57104" checksum="8390B6CD58DDF373" modified="2025-10-08" version="1">MCPRTLPAVLLDGLSSLTILFLVPAPDKEGVSLQQENMDLWKDILGSPVKIVAPMVDASELAWRLLSRRYGAELCYTPMLHSAIFTRDPKYRKEALASCEEDKPLIVQFCGNDPDIMLEAALLAQDYCSAIDINLGCPQAIAKRGHYGAFLQDEWPLLENIVSTLSKNLKVPVTCKIRRFETKEKTVQYAKMLESAGCKMLTVHGRTREQKGPLTGIADWSFVKAVREAVSIPVISNGNIQCIQDVEKCLEETGAVGVMTAEGNLYNPALFMGQNPPAWVPAEEYLDLAEKYPCPLSYIRGHLFKLFQHILSLPSNNNLRIRLGSANTMKQFKEIVNEIKGMYEPYHNGLKVWEETTERDTQNILLPPWLCQSYVREDPENHIKKVEEKKMEEKPENKRQYEDSEGRTISRKKMKRLRRISRRPEKPENLADRPSEKCSVCVNPLGSKCSYRLCKKCCRDKCYVEDLDCKGHRILVKTRRELAKMYASQEKKDIQPTSVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IF05</accession>
    <name>A0ABM5IF05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131356.2">
        <property type="nucleotide sequence ID" value="XM_028275555.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275555.2">
        <property type="protein sequence ID" value="XP_028131356.2"/>
        <property type="gene ID" value="LOC114327056"/>
    </dbReference>
    <dbReference type="GeneID" id="114327056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF6">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="3">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131356.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="645" mass="74811" checksum="0130228764C78071" modified="2025-10-08" version="1">MFRTPILRCIRQLQLLENTIKTTVVHTTSFQLQTTSLYKHPEKSELTKNKPSSSDHNFLVKLKSDPDTFGTQQEEDPLVEDDVKEDKYFTEKPLRSQKLSTKQYADIIKDLIRKRKIKEAIDVVEVRMLKEDRVKPESYIYNLLLGACGRVGYTKKAFMLYNDMKKRGLKITPGSYTALFNACANSPWPLTDGLKRATHLREIMIEKGYQPNDTNYNVMIKAFGRCGDLPMAFSLVDEMRSKKIRIRDETINFLLQSCISDKEAGFRHALLVWRKLVDKHIKPSIYTFNLLLRCVRDCNMGDVETTKDVIDTICKDRKMIEVPNIKQLEEGNSRIPPPPYEIQTTESTNSNENHQTLQVQNHLVDIVDSRPNLLAKIPHMGNIISLTEVKEPEHRLLLLGGCRGFLEEIKIRGCSPDIKTFTQLLDCIPDTVAAEQELLSSMKKFYVKPDLDFFNMLIKKRNMRSDSNAAKDVLKLIKKNGYRPDLITYGVLALGCTTEEDCVQLITEMKEGCYTLNTEILGAMLSQACYHMNIKYVMYLMDLCLTENVQPNKKFIEKLSEFKANLYNPNIEKTSSFIKNKALFKIQYKKWLNEVRVDDSENVHPWQQFRETNDNEHKYKPKDTARFKPRRLSLFKVKTSTKVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHD5</accession>
    <name>A0ABM5IHD5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132796.2">
        <property type="nucleotide sequence ID" value="XM_028276995.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276995.2">
        <property type="protein sequence ID" value="XP_028132796.2"/>
        <property type="gene ID" value="LOC114328209"/>
    </dbReference>
    <dbReference type="GeneID" id="114328209"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="217"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132796.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="341" mass="39037" checksum="05D07C4DBB913BA0" modified="2025-10-08" version="1">MVEDKETKYFTLEEIAKHNGKQGSSVWIIIKDNVYDVTDFMEEHPGGAELIMEWAGKNATKDFDNFGHSLDAKRDLKKLKIGEVDVEERKKKINKEPKVKSTKITSTNDTKLYNVSEVAKHDGIQDTRTWIIIKNCVYDVTEYMEEHPGSADVIREWAGKDATKAFDNIGHSTDAKRILKKLKIGEIPKEDKKKNSDKITPIHQENKENINNKEANTKFYSYDEISRHNGKDNPRVWIVIRDAVYDVTDYLEEHPGGAEVIKDWAGKDATKEFDSLGHSSDAKNKLKKLKIGEVVNEERNKKLKKVELNRQISIQKIKILDSSQFVNRKSCISILTCGILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IK60</accession>
    <name>A0ABM5IK60_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134678.2">
        <property type="nucleotide sequence ID" value="XM_028278877.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278877.2">
        <property type="protein sequence ID" value="XP_028134678.2"/>
        <property type="gene ID" value="LOC114329690"/>
    </dbReference>
    <dbReference type="GeneID" id="114329690"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045469825" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134678.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="107" mass="11911" checksum="65FE42E9D790D183" modified="2025-10-08" version="1">MLKPFLCIVLCVVFVKCHPTMYRMNENNVLEADLVPISSTVIPLPVYQVGYGIDVLSSHKDRNAAKPEGPIYLETVYTKKKPIPAVKSKPSSDVSTVKQVSKAEYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKZ3</accession>
    <name>A0ABM5IKZ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proton-coupled folate transporter-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135238.2">
        <property type="nucleotide sequence ID" value="XM_028279437.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279437.2">
        <property type="protein sequence ID" value="XP_028135238.2"/>
        <property type="gene ID" value="LOC114330122"/>
    </dbReference>
    <dbReference type="GeneID" id="114330122"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF39">
        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135238.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52254" checksum="387CD17B5301AE5C" modified="2025-10-08" version="1">MAPKIFSNFKPTIEIPLLLVYFAFMTYAGIVTNLISFKTCYTLENYPKENCSRLGRYTDNATLDLEKTVQSKSTYVLTITEMIPSSVPILISLGVGAWSDKHGRRPALIYTLCCLSVGFASYVIVLLFDDLNPYYMMVGAIPALLCGGPLTFFSIAISVMNDVSTDENRGLTMAVFEVIMVFCTCFGTLASTPLLYATSYAAVGGFCAVLIILATIYTYFLVPESLKVGEDNKATVSNVFTCKNLTELFVVAGRKRSNNKRFILLTWLSILFILNIINSGEGNVKTMYLRNVFEWTMTDKNEFTAWGSVVGMVATIGLMFILYKKLKMKEASLVILGFISAIGSSLVYALAKENWHIYITVFIGIFVGMINPMIRTSIAKILPRDDMGKIFSLITVVNSLLQMVSGLIYSLIYTETKSGLYNYVSIGFDVIALILVLSIILVSRQSNETESVSTKEDVHESGDEKTNQELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IM66</accession>
    <name>A0ABM5IM66_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136252.2">
        <property type="nucleotide sequence ID" value="XM_028280451.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280451.2">
        <property type="protein sequence ID" value="XP_028136252.2"/>
        <property type="gene ID" value="LOC114330999"/>
    </dbReference>
    <dbReference type="GeneID" id="114330999"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136252.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="392" mass="44172" checksum="6AA8B28920A63234" modified="2025-10-08" version="1">MLNQRLGIPVQMPDINRLHLHFVPSTYTPQRNESPRYISQPNIYEEADSIRISPIDPRNSAGFQSSTPSGKTELRAASNLENKLLSPKKSTMSNEELYAVIHKSKKKMNIEAEDSPRSSPLTVQETSKKQTKSPETGYIGDKSRSRLSWSPSKGEYIDFNEDIDKLSPPNDSRTRQSWACSDRKPKPKQTSTLDFKRLLLQKSSSNSPKKLSAVEQLKMSKQQIKPSPQKLQPEMNILDLSASPRSLVNRKFMHNPPGSPNREQKPLTKVLSPRSQWRFASPRSDVLSSPILEDCREDESPNSSGERKKSPKNRSSNSNTESSPKNRSSNSNTETSPKGMPRQTHSTPYTSATQRLYAQRAQFFSPVTPKSSQVKSQEKDKKTSPPTLETAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMA3</accession>
    <name>A0ABM5IMA3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028136331.2">
        <property type="nucleotide sequence ID" value="XM_028280530.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280530.2">
        <property type="protein sequence ID" value="XP_028136331.2"/>
        <property type="gene ID" value="LOC114331055"/>
    </dbReference>
    <dbReference type="GeneID" id="114331055"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136331.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="257" mass="29917" checksum="A92A1398239DDA8A" modified="2025-10-08" version="1">MKKLLIINKKYSTLCLNNFRSFCTKFNTFQDDFEKNHIETNFMQRTLLSVGSAAVSLLNPHRGDMIACLGETTGEGAAKYVLSKMQEDKEGCKILQDQPRINTRTVDLKYLERLPDGTLGKTYSNFLIKNQVTPDSRSPVQFVDDIELAYVLQRYREVHDLIHTVLQMRTNMLGEVTVKWVEAIQTKFPMCIGGAIFGPVRLLPKHRQRYLKYYLPWAIQTGTNANFLLNIYFEKRWEQPLTEFHKEMNIEPLKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMT5</accession>
    <name>A0ABM5IMT5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan anchor biosynthesis class U protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136701.2">
        <property type="nucleotide sequence ID" value="XM_028280900.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280900.2">
        <property type="protein sequence ID" value="XP_028136701.2"/>
        <property type="gene ID" value="LOC114331352"/>
    </dbReference>
    <dbReference type="GeneID" id="114331352"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136701.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50739" checksum="F1600A4314F3923B" modified="2025-10-08" version="1">MSLKNFTTTPNDPVSTVRIISTCVSAIILRYYLMLSKYQSVIANHVEVSTPLNSWKRVSEGLYLLSLNINPYNGDVLHETPLSLYWYKTSLQLFQGKVHLIFITLEIATSIVLYYTIKRFAAVIYEEEERDRKTFSKDAEDSLLKPEKIFRTPYYVLLAYLFNPYTLLNSVGFSTTVFYNFYLSVVLFSMVYGLPLLCGVFLAMSASVSFYPVVLLLPASFYYQQIFKSSLKTVTCVVSFIVTSLLIVSVCSDSFNNFSYIRNVYGCILNVPDLQPNIGLFWYFFTEMFEHFRELFIYAFQINTTILYLVPVSLKFRKQPFLLAIAINFIITIFKSYPSVGDVGFVLSIMPAFPHLFQFSQQGFLVGTMLIISSCLGPIVYYLWIYCNSANANFYFGVTLAFAVAQIFLLTDILFAQVQRQYMLKFGKERKVDGEEGTLCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYG5</accession>
    <name>A0ABM5IYG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028149430.2">
        <property type="nucleotide sequence ID" value="XM_028293629.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293629.2">
        <property type="protein sequence ID" value="XP_028149430.2"/>
        <property type="gene ID" value="LOC114342821"/>
    </dbReference>
    <dbReference type="GeneID" id="114342821"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045670581" description="beta-glucosidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149430.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="498" mass="57227" checksum="740A98EC9914791D" modified="2025-10-08" version="1">MKLFILICLIALCFSANAKDPINNRRFPKTFKVGVANAAPQIEGAWNTDGKGETIWDHFAHTQPEKFIDRSTPDVACNSYYQYKEDIAMVKEMGLDHYRLSIAWSRILPTGYLDSLNQLGVQYYKNVFKELKKNNIEPLVTLYHWDLPQPLQDQMNGWINETIIDIFADYCKLCFELFGDDVKWWITINEPKQVCQAGYGSGAFAPGIVSNGIMDYVCTKNVLLAHAKAWHIYDEQFREKNKGQVAMVIDATWYEPGSDNQEDKDAAERAQQFDIGIYGNPLFNGDWPEIVKERVAYRSKLEGFTESRLPAFTEDEIKYIKGTSDYLGLNHYSTLLTNHTADAPIGSPSFDNDKSVLLWHRDDWTQGSADWFFDVPWGLRKFLNWLKNTYGNPEIVITENGFADTNGTLEDDNRITYLEGHVSACLDAIYEDNVNLTAYTVWSIMDDWEWTGGYTSFLGMYKVDFNDPNRARIKRKSADYFTNVVKNRCLVEESQCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHY1</accession>
    <name>A0ABM5JHY1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050497544.1">
        <property type="nucleotide sequence ID" value="XM_050641587.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641587.1">
        <property type="protein sequence ID" value="XP_050497544.1"/>
        <property type="gene ID" value="LOC114336421"/>
    </dbReference>
    <dbReference type="GeneID" id="114336421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="207"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="287"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="600" mass="68818" checksum="7618A9F35BC355F9" modified="2025-10-08" version="1">MLKNTVFSMKNSPITRSRKIASKRMENTDNVLLKASEFIKGRLYFVSVNCTVDLTSTKTVHYFTINKDIKYDSFHRDFGPFNLAMIYHYCMKLKRKLSNPSLQDKKIVHYVKDCTELDGQKRVNSAFLVGAYSIIYLGYSPERAYEILTEKSTKEYLKFRDASIGEPYTLSLFDCLKGIKKALDHGFFNLSDFDYMKYEHYEKVENGDLNWIVPDKFIAFCGPQGITYSLGDHKPETYFPYFRNHNVSTVVRLNKKAYDSNAFIEAGFDHKDLYFVDGGTPSERILQQFITVSENAKGVIAVHCKAGLGRTGSLIGCYIMKHYKFTAEEAIAWIRICRPGSIIGHQQSWLQEKQKQMWETGDTHRKKHGITAPIKHKTGIYSLSVENKDENSNPDTVRKIAEEVDHMDLRDSDEECDEESQGNQLNRIKLQRGKIANINSCNHKQSERIRKVSVNMTSNIIRTPGKVTTTTKTFGCTESSRVVTKRIDGQSLRRATKKKITSSMVTVTTAKTPVVEKRQVMKKKDLFQNVVNKAVKKEEINNGEVASNQNKAKKRVLAREREMARRAKMLRRTHPIALTYNKIDKTETVQTSTVKVNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKE2</accession>
    <name>A0ABM5JKE2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498405.1">
        <property type="nucleotide sequence ID" value="XM_050642448.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642448.1">
        <property type="protein sequence ID" value="XP_050498405.1"/>
        <property type="gene ID" value="LOC126879436"/>
    </dbReference>
    <dbReference type="GeneID" id="126879436"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="137" mass="15796" checksum="04BAC28271423290" modified="2025-10-08" version="1">MLEDGNYKLYWDRSVLTDQTVAHNRPDLVLVNKLTRQTTLIDVAIPNNNNLRSKFTEKIAKYRDLEIQIRRQWRMQSTQTIPIVISTTGVVPKTLLESIKKLGLNEHLYKTMQKAVLLATARSVRKFLGDTPAFQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKF7</accession>
    <name>A0ABM5JKF7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498420.1">
        <property type="nucleotide sequence ID" value="XM_050642463.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642463.1">
        <property type="protein sequence ID" value="XP_050498420.1"/>
        <property type="gene ID" value="LOC126879448"/>
    </dbReference>
    <dbReference type="GeneID" id="126879448"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="185" mass="20837" checksum="7B1D3C3818F3CAC5" modified="2025-10-08" version="1">MTEDGEQTPPTPGSSTSGNDVDVEKAENIKSLQAGEDNEPLEKAKEKPPPGINASLVMLYAVFFAMFITGWVNLNSCPLNRLIPIYLIVAGFVGALAKFLSKTDNKHVFNIAMVLVIFDIFWHGLGTYVVYTEYQPNYDINSKNYCNRTAYLLCFWILTFQYTLLGIFIMLSACYLLMRGDFKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JL31</accession>
    <name>A0ABM5JL31_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050498646.1">
        <property type="nucleotide sequence ID" value="XM_050642689.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642689.1">
        <property type="protein sequence ID" value="XP_050498646.1"/>
        <property type="gene ID" value="LOC126879535"/>
    </dbReference>
    <dbReference type="GeneID" id="126879535"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045000580" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="31"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="552" mass="61775" checksum="3A8999A6F3CB80E6" modified="2025-10-08" version="1">MIMNAIKLLQLFLLVATIEKSATRSFKDDGTIVHLDEGKIRGHILKSENGNDYYAFQEIPYAEPPVGENRFQLPKLPKPWTGVLDATRNTKICFQDIPLYKNLEISEDCLYINVYTPEQPGSNKRLPVLLWIHGGAFALGGGTFEYVGPKYVMDAGIVVVSFNYRLGPFGFVGTNDGVIPLNLGLKDQKLAMEWVNKNIHLFGGNPDHVTIAGQSAGSISVGYHLTGPWENDKQLFHAAIMQSGSPVSGWLTQEDETSSALALGRAVDSHFATKDTKELLKVLQKAKARDILYARPTSGVSTEAEGPFSYGGFEAFLSGNYKKVPVLIGFNSEETAPQAILNGVAAILLGSVDRNPGQLVDRRINMSPEDRATAGSLLKQLYTRNTSFREDFGGYIRHSSDQLFANGICKQVELASPNMPNYLYQFAYKGEIGQETWFLPFLPPDVEKVAHVEDTHYLWDDGSTTDLSKFPKSDQLVLHKYVKLWTNFVKFYNPTPKSDAFLDNVIWEPSEPNSLRYLNINETLSMQENPRQYKEVNEIMEKYMQPPFVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM67</accession>
    <name>A0ABM5JM67_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499032.1">
        <property type="nucleotide sequence ID" value="XM_050643075.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643075.1">
        <property type="protein sequence ID" value="XP_050499032.1"/>
        <property type="gene ID" value="LOC126879809"/>
    </dbReference>
    <dbReference type="GeneID" id="126879809"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="216" mass="25311" checksum="C101AA684AB74DDC" modified="2025-10-08" version="1">MEVKQETSESEETSCKIELDNEEFDHGTDGTLDDFKIEIEKEPKREPAYNAFDYLYIPEKAKVEQDEYKFNICEETQTTNEEKMEPDVCASSLYIHLDNEAILNESKSIVMNLSQGTKKEEIMKEKEKIIEEFLNATEKIYTKEQLDILRKTVAPLAPNLKALDNTVQAKITLLKKKNKMPHNKKIQTQRRLYSTKKKTRKIQERMLSKDLLQMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMN3</accession>
    <name>A0ABM5JMN3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499199.1">
        <property type="nucleotide sequence ID" value="XM_050643242.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643242.1">
        <property type="protein sequence ID" value="XP_050499199.1"/>
        <property type="gene ID" value="LOC126879898"/>
    </dbReference>
    <dbReference type="GeneID" id="126879898"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="121"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="47876" checksum="D0638448C051C25A" modified="2025-10-08" version="1">MDIAKEHRALVDSIARENGFTDYEVITSSGSSKGDNFLGVLTAITIKDKEKSLDLILKSSHTNKGFREATPIKEIFSREIYIYEQVFKEFKKFQEEHSIEDPFESVPKFYSSFAEDELEGLVMENLKTQQYELWDKKVPMNPGHIKAVLIEYAKFHAVSFAMKQKNPALFKKLSEKNGTNPFEKKNASEKDNEERYKKFFSDTLSNGYKVLKDDPELTEKLKKYEQIVDTEFMSKLKEPEYKLVITHGDCWCNNFLFKYQDPNDKTKPEDLRIVDWQISSFGSPCADLAYFLLVNSSEEVFNDIQTYLKIYHDKLSSQLRNFNLDPDELFPFSRLSDHLNQFLLQSFFFVFLLLKIMVSDKEDIPDHVEEVDKSGDSMTMLSYETKNVEEYTRRVKIIMQFLIKNKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT35</accession>
    <name>A0ABM5JT35_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501098.1">
        <property type="nucleotide sequence ID" value="XM_050645141.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645141.1">
        <property type="protein sequence ID" value="XP_050501098.1"/>
        <property type="gene ID" value="LOC126881097"/>
    </dbReference>
    <dbReference type="GeneID" id="126881097"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF434">
        <property type="entry name" value="FI01124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="594" mass="69878" checksum="6CFC199977F5F0AC" modified="2025-10-08" version="1">MESNEDTKSKQNVLMYEKDGDSLTLEQHVNVNVQIKSELEECTFESNDTQDSLLDSYGSDDIKIEEHKLECSPLSPFPLITQQRVKTEIKKEPNEHNLVVNHGWETRFKTCNIEELDSDKDVNLQIAASTEIHHEKPYRSMKKSKLLSNIGKESLHQTDIKTKSERSEITHNEEKPYKCEICSKEFTYWCRLKSHLRIHTGEKPYRCEICFKQFSEDGNLKRHLRVHTVEEPYKCKICFNQFTEKGALKNHLRVHTGEKPYKCEICSRKFTHDGNLKQHLRLHTGEKPYKCQICSKEFSKDGNLKQHLRIHTGEKPYKCEICSKKFSKDGHLKQHLRIHTGEKPYKCEICSKEFNQGGALKNHLRIHTGEKPYKCQICFKQFSRGGALKNHLRIHTGEKPYRCEICFKQFSEDRNLKKHLRVHTVEKPYKCEICFKQFTEKGALKNHLRVHTGEKPYKCEICSKEFSKDEHLKQHLRIHTGEKPYKCKICFKQFNQGGVLKNHLRIHTGEKPYKCKICFKQFNQGGALKNHLRIHTGEKPYRCQICFKTFNEAGTLKRHLRVHTGEKPYKCEICSKKFTRYGHLKIHLRIHSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JV84</accession>
    <name>A0ABM5JV84_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501851.1">
        <property type="nucleotide sequence ID" value="XM_050645894.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645894.1">
        <property type="protein sequence ID" value="XP_050501851.1"/>
        <property type="gene ID" value="LOC126881571"/>
    </dbReference>
    <dbReference type="GeneID" id="126881571"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045744183" evidence="1">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="120" mass="13986" checksum="CCF26C157397F1E9" modified="2025-10-08" version="1">MRTAWLLLLVVCLVVFVEDISCGTTIINQPRKTELSEVKHPSHLIQERSAWDQMYALARLPGEIMRYDFISFAMDVIILSRFLPLNWFIAKTLEFVYIALKYFQPIYWKAFPSTAPANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWS3</accession>
    <name>A0ABM5JWS3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil-helix-coiled-coil-helix domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502388.1">
        <property type="nucleotide sequence ID" value="XM_050646431.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646431.1">
        <property type="protein sequence ID" value="XP_050502388.1"/>
        <property type="gene ID" value="LOC114345243"/>
    </dbReference>
    <dbReference type="GeneID" id="114345243"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15478" checksum="3E9C567A0D5EF65B" modified="2025-10-08" version="1">MPRNKSKAPQKKAKSNQRKREYYTVPAKAHTSNKVSKVAPVDKDEKRPGVFGQMAATAGGVAVGTTIGHFVGNILTNIIGLASKKTTDSNNDVQRYEEPRRSCSKEIQQFINCAATEKDITLCQGFNEAIRECKQKHNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWV7</accession>
    <name>A0ABM5JWV7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502417.1">
        <property type="nucleotide sequence ID" value="XM_050646460.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646460.1">
        <property type="protein sequence ID" value="XP_050502417.1"/>
        <property type="gene ID" value="LOC114349007"/>
    </dbReference>
    <dbReference type="GeneID" id="114349007"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="364" mass="41269" checksum="FD3448C63D873B16" modified="2025-10-08" version="1">MLNGHFGIVGAGLCISQNCIISLPLVMKTILLFVSLLLVVSAARKEKKTTLEDVERGYITTKARLSPPPPPTSTKVRSKSPTQFGYIPVKTPANYVQKEPKITYAPPQYISLNQGKIKYQTEPQYSTIQYASGSQYTTGPVYTGPVYTGAGQGTPQRGVQKAPVDQTQEYYVPQQEQSQYLNYDNVQYVADNNIDQGAGQQHYNPQQYYYLQQQYQAPTTSIQAVVDPKGGLQYIMYIPTYVSNQGSQQQSTDQTQNYENVVYSDNDQTYQQPQSSPQYTTYTEKQPTLETGKSAYNVKATDFTFKREPKSLLDSYVPSVLQLQYYKQAQLNSIRDSEKYESYINPTGAESSYRYNYRPTPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXF3</accession>
    <name>A0ABM5JXF3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 5 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502618.1">
        <property type="nucleotide sequence ID" value="XM_050646661.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646661.1">
        <property type="protein sequence ID" value="XP_050502618.1"/>
        <property type="gene ID" value="LOC126881925"/>
    </dbReference>
    <dbReference type="GeneID" id="126881925"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="78477" checksum="BF134FFAF899B4D0" modified="2025-10-08" version="1">MVKETTTSIKKKRKVSNPEHEGDNDIYKKVANFEEKESLNSQASLEANVYFELCEDIRNLLAKAMSLRQKDKKSNEIKDIHAEIVVKMCMVKKLNRTDKIRHVHGKETLTTEKQKCDSIKLTYQNLVYERHHLVTETNKCLAFRSKDEDIELVPFEEFMREAPESLSSKFSSYDPDDREQQHSLRLARLEWELTQRKNLAQLCKAFLEQKKKLSEDLLLRKDKLTALTPLLVNVINATKPLQDHLEMSPSGLRVEHKLAYLLPDPLYIFYVNVVSYKVVYDINLDVEIIGDEEEANRWKDLKIGMGFANDDESDTPETEQDAAEIEEVVEIKKRRHRRSVQQIDPMEEKRKKLLESHPLQVQIVAKLKDGPLLTIKFSYLIKLKIITVMSSTNCSACKITGNSAREVLTGENLLSELVEDDNGLESPNPITKFQIKKIGLTSFQSLVPQIGYAYHWAQRVCGRDFLNKKMDSDELGRTNVEIIMKIIFKRLESRYQLATQLQQLEQNTIPTMPKPADCPVSFTCSISKWIAISYQKYCQLEFTKTFLEEELVAPSDLFYSLQISRGSASLEAFIVIKSNYPSTLPIISVCVNYNGVHHSENDDEIRDMERLLNVSVREALSPSVLSLQIVRLCSYFDVYLETTNPKEFPQTVTFVKSVSARNRRRPFIYRKVGNGIFTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXS2</accession>
    <name>A0ABM5JXS2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502741.1">
        <property type="nucleotide sequence ID" value="XM_050646784.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646784.1">
        <property type="protein sequence ID" value="XP_050502741.1"/>
        <property type="gene ID" value="LOC126882012"/>
    </dbReference>
    <dbReference type="GeneID" id="126882012"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12223" checksum="2B80E439D12618F2" modified="2025-10-08" version="1">MVRTYVRKSNQQSWSEESMKNAIDAVREGTLKYKAADTQFNVPPATLFRRLKLDRTSDLAAKKRLGRFRTVFTPEQENELNEHVLDMERHNLFGLTIQNFRHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXW3</accession>
    <name>A0ABM5JXW3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502780.1">
        <property type="nucleotide sequence ID" value="XM_050646823.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646823.1">
        <property type="protein sequence ID" value="XP_050502780.1"/>
        <property type="gene ID" value="LOC114332614"/>
    </dbReference>
    <dbReference type="GeneID" id="114332614"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="934"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="960"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118180" checksum="1750CCBC761933F7" modified="2025-10-08" version="1">MNSDNQNVLPTVHSAPNTEALSHRSPATTSVPTDLRVNTTALNAVALSNVAKYWVLTNLLPGPIPQVSVYGLPGATRESQGKISQDAVLSQHSFLQADPLLIQQHTQIPVSIATSQHQGNLGLSASAVHLENAHNVSSHHTSENLSSQTANQLSRDIRISHSQHQSQQSQQQHHQQQQQQQQQQQQQQQQQHQQNAQNLVQVQVQDNLVSVIEDTKDQKDILSAQLQAAQLQLSENHLGQQPLTVQQLQHLQVQQVLENAVRLENSVDNNQNQSNNDHQDSLTETIQIVKDEKAFPNCKLVSSSQFGLQELKSNLMDVRTADGSIVKIQTNMQEQELVKTLGLDIVNNMYKVNVDDLNQLLAYHEIFGKLQGTQGTDLSNNTQNLTQNSNHLNISNSNIIIAAKDEQEPSTSNITNENLSTVVANHSCDLCGKMFQFRYQLIVHRRYHTERKPFTCQVCGKAFTNAQELTRHGKCHLGGSMFTCAVCFHVFANDASLERHMKRHSTDKPYACGICSKTFARKEHLDNHTRCHTGETPYRCQYCTKTFTRKEHMVNHVRKHTGETPHRCELCKKSFTRKEHFMNHVMWHTGETPHHCTVCGKKYTRKEHLANHMRSHTNDTPFRCEICGKSFTRKEHFTNHIMWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCGFCAKSFTRKEHLINHVRQHTGETPFRCNFCPKAFTRKDHLVNHVRQHTGESPHKCTYCTKSFTRKEHLNNHVRQHTGESPHRCHFCSKSFTRKEHLTNHVRIHTGESPHRCQFCQKTFTRKAHLTNHLHQHTGESPHRCEFCQKTFTRKEHLTNHLRQHTGETPHCCNVCSKPFTRKEHLVNHMRSHTGERPFACNECGKSFPLKGNLLFHQRSHNKGADAERPFRCDLCEKDFMCKGHLVSHRRSHMSDRPHVCPDCGKAFVEKGNLIRHLKKHAADNAQTQPNSQIQPQGTAPPQNAQPTSNAPNIQIPQVHVSQPPQLQQTSSGNIVQTSHLQMHPSNAHSVVPTANTNVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0F3</accession>
    <name>A0ABM5K0F3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-soluble NSF attachment protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503671.1">
        <property type="nucleotide sequence ID" value="XM_050647714.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647714.1">
        <property type="protein sequence ID" value="XP_050503671.1"/>
        <property type="gene ID" value="LOC114329658"/>
    </dbReference>
    <dbReference type="GeneID" id="114329658"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33576" checksum="905709A6D1D6AEB5" modified="2025-10-08" version="1">MSHIEFKALQLQEEAQRRVKSAGFLQSLFLRSTSKSEESIEYYKRAGNLFKMVKKWKQAGSAFMDAANLCYKAKNFTEAALEYIEAANCFKNCDTEMAIKAYKEAVKLYRNNGKYSAVAKNYEAMSELLQEDYNNQGAEKYLEQAAYFYQLDKRYWASNKCLEQIAEAAALSSDYVKAIKIFEGIACFELTSSTRKHIANEYFFRCAICVLCAGASVTKRLLTYIYIFPPFKTSREYELVVCLAECINDNDLEGFEYAVRIFDSQTELSQWHVTLLLRARNQITENEHLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0Y0</accession>
    <name>A0ABM5K0Y0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503852.1">
        <property type="nucleotide sequence ID" value="XM_050647895.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647895.1">
        <property type="protein sequence ID" value="XP_050503852.1"/>
        <property type="gene ID" value="LOC126882811"/>
    </dbReference>
    <dbReference type="GeneID" id="126882811"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="497" mass="54700" checksum="9BE6F16F84428094" modified="2025-10-08" version="1">MENSQSNSKAERKYGLQEVKYIPVELEQGVPLQPENGVKRSDTFFLQFTVMTALLIFMVGGTIIVWTSPAIVKMKSNDTSINPLGRPIETYEISKFMGTVGILAMGGALFLPKLADVIGRKKSLWVMAFFMFIGIVGLGFSRSVNVMIMCSTLTSIFFCGAMGILPMYLTEICEDHNRTKYGCLMSAFIPLGQLYTYLIGPVFSYTVFTILTAVPMIPFLVLFLFAPESPVYSLKNGRREECLRALKKLRSNKTDRELDNDLHNISKALATTNKTEGNSVGKLFGTKEGRVGMLLSLLPLFAQYFSGVPILMMLMAPIFNESGSFISGSTIGVCVGAVKIFLFTTTSLIVERFGRRPLLLMSASGAAIPISLLGVFFYLKHINSPLVPLYPWVPLACVLTYISFYAMGLGPIPITVMGEMFSSDTRSTGCAIVTTVSSLALTVYVSAYPILAEAIGTHWCMWIFGSCCFGGALLIYFLLPETKGKNVVEIQEILKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1P2</accession>
    <name>A0ABM5K1P2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504108.1">
        <property type="nucleotide sequence ID" value="XM_050648151.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648151.1">
        <property type="protein sequence ID" value="XP_050504108.1"/>
        <property type="gene ID" value="LOC126883003"/>
    </dbReference>
    <dbReference type="GeneID" id="126883003"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="220"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="684" mass="78445" checksum="301452599A7D891D" modified="2025-10-08" version="1">MCCVTMSKRSRKIVELALRDAEMSGDESDPFSSLDSDLDPMFLPTSDEEILSSSDFSDIEASSDMFSQKITLSKPKSNIKRKLQSSKITSKKLCTRNVLEQPSCSTSLLPDDASEEEEEVADATATIPFTATDDNMLSKNLEREQNNISSEQLEEFFDVETLAQTQLADTDDIQENEVGANQNVLEHTWTQPIGNHHEFEYSAEDGLCGNYAAILINDLSPYKCFRTFVDDEIIDEIVNQTNLYATQILCDSNDITNDSRLQRWVPTDKKEMIRFLGIVAYMGLVKMPSLEKYWSNDDLYKNVIIPKTMSRNRFQLLLRMWHFSDNERCPEGDRLFKVQPLLEKLIKNFQKVYTPGRTFCVDESIVPFQGRLIFKQYIPQKTHKYGVKLFKLCGGNGYTWNLRIYAGKETREGNASVPTNIVINLSKDLLNSGRTIIADNYYTSLELTNILLENKTHYIGTLRANRRGNPKDVILKKLKRGEVFGQENEKGVCVLKWKDKRDVLLLTTKHTTETVAIQRRSGVVQPKAIIEYNKGKSSIDQSDQMTSYNSSLRKSLKWYRKLAIEFILGTAVVNSHIIYNQLANKKVKITEFREELVRSLLTYDEINDDESETTQSTSTKSAQIHKLLKKEGPFNKARRYCRGCYAKKLRGEISKNRVKKVVTYCDICEDKPHFCLDCYNIHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2L2</accession>
    <name>A0ABM5K2L2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504426.1">
        <property type="nucleotide sequence ID" value="XM_050648469.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648469.1">
        <property type="protein sequence ID" value="XP_050504426.1"/>
        <property type="gene ID" value="LOC114336768"/>
    </dbReference>
    <dbReference type="GeneID" id="114336768"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2149"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2427"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2780"/>
            <end position="2960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="84"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="908"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3414"/>
            <end position="3455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3627"/>
            <end position="3703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="4838" mass="558464" checksum="A0C68281DEA13EC5" modified="2025-10-08" version="1">[encoded data, 4838 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K585</accession>
    <name>A0ABM5K585_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505351.1">
        <property type="nucleotide sequence ID" value="XM_050649394.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649394.1">
        <property type="protein sequence ID" value="XP_050505351.1"/>
        <property type="gene ID" value="LOC126883731"/>
    </dbReference>
    <dbReference type="GeneID" id="126883731"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="651"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="738" mass="83708" checksum="9288070FD35B80BD" modified="2025-10-08" version="1">MDNSKPKQKTLTSFFSASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEGKLGCKVCFEVTTMGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKPIFRSAYYIAKNDRPYNDYFGLLELQKLNGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVSGKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELASGDAVSEVAGVNHFQIFMDKLYSLYSASPKHKRELKDCAQELDIQMNKIGRVLSTRWVASSFRTVSAVWFGFQALANHFSKAINDPDRTSTEKSKYSGLLNRLTSQSFLLNLAFMFDILAELALLSESLENRNTSIVYADKLINRSVRYLEHLKEKPGTKVLEAQIAIKEGNFASVVLKTNPKIVSFNGQQLISSVINNLKQRMFVTTFDGEAQYEDLINSFKVLEPEYWPTCIPPSFGQTQVEQLCKRFKLNVNKAVSAYRDYLDNSRQVPDGLQELLNCTKIIPCSSADCERGFSCMNNMVTPSRNALTVAHVSSLMFIKIQGPPLQEWQPETYVTKWLRSHRSADDSRTRVAENPKKNAKKDAFWHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6Y9</accession>
    <name>A0ABM5K6Y9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transcription factor Y subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CAAT box DNA-binding protein subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nuclear transcription factor Y subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505958.1">
        <property type="nucleotide sequence ID" value="XM_050650001.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650001.1">
        <property type="protein sequence ID" value="XP_050505958.1"/>
        <property type="gene ID" value="LOC126884140"/>
    </dbReference>
    <dbReference type="GeneID" id="126884140"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="203" mass="22864" checksum="990136B49EB2CB88" modified="2025-10-08" version="1">MEKVEDMTHSYALAPLSDQYMVQVEDMEDEHDQLTAENTDDSNHDGDKCGVPLREQDRFLPIANVAKIMKKAIPDAGRITNKIAKDARECVQECVSEFISFITSEASDRCHMEKRKTINGEDILVAMSTLGFDNYVEPLKIYLQKYREAAKSDKNLSVDVMYEDVQEEAFSSAGNNILSAENGGTETVLYTYQDNGIQQFQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAC6</accession>
    <name>A0ABM5KAC6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507138.1">
        <property type="nucleotide sequence ID" value="XM_050651181.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651181.1">
        <property type="protein sequence ID" value="XP_050507138.1"/>
        <property type="gene ID" value="LOC126884872"/>
    </dbReference>
    <dbReference type="GeneID" id="126884872"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="127" mass="14609" checksum="843BDC0B0FC7A433" modified="2025-10-08" version="1">MEQEAAHFKTTENLLIPLSKLTDRILAATGISKNTLTKIRKEGRYVNKNEATSLSFKSPKRKRCRSKKIELSTGQVKTIKNIIYDFYTIEKRSPTINGIYQKLKNKQMEFPGSKETLRKTIIGLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAD0</accession>
    <name>A0ABM5KAD0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507142.1">
        <property type="nucleotide sequence ID" value="XM_050651185.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651185.1">
        <property type="protein sequence ID" value="XP_050507142.1"/>
        <property type="gene ID" value="LOC126884879"/>
    </dbReference>
    <dbReference type="GeneID" id="126884879"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25012" checksum="5B6F9C9BEABE2722" modified="2025-10-08" version="1">MPRSKTGKKRETINPESLMGALESIFHEDPTKRISCRQASKVFKISRATLAREARKFQEPERGEYHYSQFREYGTLQKHSRVHTGEKPHKCEFCFKQFGEAGSLKAHLRIHTGETPYQCEVCSKQFAKKVHLTAHMTVHTGEVLNKCEICSKQFITAHNLKVHLLLHTGEKPYQCDICSKRFARKGQLAGHITVHTGEKPYKCEICSKQSRTAVDRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAF2</accession>
    <name>A0ABM5KAF2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507169.1">
        <property type="nucleotide sequence ID" value="XM_050651212.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507170.1">
        <property type="nucleotide sequence ID" value="XM_050651213.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651212.1">
        <property type="protein sequence ID" value="XP_050507169.1"/>
        <property type="gene ID" value="LOC114333597"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651213.1">
        <property type="protein sequence ID" value="XP_050507170.1"/>
        <property type="gene ID" value="LOC114333597"/>
    </dbReference>
    <dbReference type="GeneID" id="114333597"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21212">
        <property type="entry name" value="CH_NAV2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1729"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1738"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1748"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1759" mass="191273" checksum="4374593B2F5EEF06" modified="2025-10-08" version="1">MFPGCIKTPRSAQGSTDDITKQTKSIVQIYTDWANHYLEKGKSKKRVSALATDCSDGVLLAEVIESVTCQKIPDVQRKPKTPNQMLENINACLSFLRSQHVAGIENVSAQELRDGKLKAILALFFALSRHKQAAKSCSRHGGVAQQPQQDMTPNRSSGIVHKGGSSIPLPGSSLPARRCPPDKVRPVASSSRSTSPALSMIPRAPPSQIASPYQSNNQSQKNSMLDKLKLFKNNEKPVPVSNGKRTSSSSGVSSARSERSDSSISLEPNVDLKPIRNTSRLKQTRPGKPAQVKNSPNSTKKEVATNKSNKTATDVEKHAYKIANLPGTKLAEPKIRVTASKEPPPKANHVPIHNGTAQAVPGTGIPKPTAAVKGTTKISRDTSVTSFKIPNSTSISRESSQVSLKQQKAAVALISPIKNEKDTTQLSESSHSASTGHHSNSSESSVIYKPSSESGSECHNIIPNRKEPVNYITAVTDQSPPPPAPQTPKEPPCDENKDQHSDKEINNISYNNLVNREKLDISKETEKDILNHIKDVYLEEKDENLSIEPMRPLLRGYCSTLTLPPRQRQYQRVQPDGGSDYCEISLANGYLSDGEVLRNTVVMDIGDGYLSEGGSILYTRRLQTMPAHLPNGTPRLTPGLTVLTEQSSRRGGSSESPPPPPAPRVTSKSSRNGIPLQDSKHAYQEGKHGHLESKHDSKHSHHQQWKRYTDSPGVGSPPPPAPAPGSPTQGRRERRASPHGSSSGKDKSGKGARGVPQSFGYFKRNGSGMNGQVNGNSNGQTVQVIQNQSTGKTAAVSAVPRTKVKVSGGTQTCSSDLQQSHKASPPQFKSYSLTGNTANQLSQSVRERLMMGSQSLPKGAVTHQEYGLVMRARPKVSDGSLSDTQAIENTSPYAPWLRHSNTYSVAPRLSETDSMESLTSLPGHRSSLTHARLLRDSPSRLSRSNSISYLRERTFPRSTKSEKLYPSMLHRNTEPETEPYYCLPIGSLSHWSQPTSPAPGSARTFPLSPTHSSTPRHSMPKNDDVHGSSISLVSTASSLYSSAEEKQAHEIRKLRRELTEAQEKVHTLTSQLSTNAHVVSAFEQSLTSMTQRLQHLTATSEKKESELQELRQAMEALRAQSIQAGIGSTLARQPSSDSVSSLSSACSLDKHDKKKKKGWLRSSFTKAFSRNAKVTKVQCQNDATEERSHSPPPPPPTDPGLEVVELQKQLREKDLVLTDIRLEALSSAHQLESLKDTVMKMRSEMLSLKQNNERLQRMVTGTTNMPTDLTDTRSSSSIDALSDLIPTEEPTQEVETDGKRITISVYLGQPQSFEKYYTDHYGYDGLSDNANIEISIAHTNIGASTSWAQLDNAVRRAFKQYVARLDPGGGLGLGSDAIASYKLGEAERKPDSGPPDLLPVGYAIGRVATLHVVLQPVAALAFEALIPKGVAQRLVSLLAEHRRLVLCGAPGTGKTHLATRLAEFHAQSLGRDPAEAVATFNVDNKSGKELRQYLTHLSEQAAAGDNSVLPCVVVLDNLHKAGTLADALGSLPRNLPCLLGTMAQSACSATSLQLQHGFRWVLVAPHMEPARGLLGRVLRRRLATLELEQGPQPELAAILGWLPRIWQHLNAFLETHSSGDVAIGPRLFLSCPLELDAARAWFADVWNYSLAPYLREAAREGLQLYGRRAPWTDPTQFVLETYPWPGSPPQGLTTISAKDVGLEVGPSAQSENEGDPLLNMLMRLQEAANYSSPHSNDSDCNSLDSNLTHGSNLGTESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAV7</accession>
    <name>A0ABM5KAV7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Radial spoke head 10 homolog B-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507317.1">
        <property type="nucleotide sequence ID" value="XM_050651360.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651360.1">
        <property type="protein sequence ID" value="XP_050507317.1"/>
        <property type="gene ID" value="LOC114335842"/>
    </dbReference>
    <dbReference type="GeneID" id="114335842"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="106709" checksum="751C3E7E53F3D599" modified="2025-10-08" version="1">MSKNERPSRNPSVGRGLTTSNFLPRKPKRGRRTNPESIRLHKSQLYYVPEEPSTRRGIIEKFLDFLLDIQGVKRETLLRKLHDEKSVNIVTTTHTEKDFKDIEDKDLKQATVITANGSKIVLDKTVSLEPHDPLSKSELFKTTNFVPSIKRQPSGIPSANRLPKLNESFGRRTFTSLEVIKGISEAHVALEDPVFIRIEKIYFPNGNIYEGPTNEYLIHGNGKFIWADNTSYKGDFKDGYITGKGETVLSDMTKYEGEFCNGFFHGNGFLNILNSPRCYYGEWKNGKKDGYGWMMYEPGNWYEGEWSNDLRHSKGLRKYKNGSKYSGEWVGNKKQGKGKILFCNDDYYFGEWYDNKPHGYGEYIWDLVFNETFCFPLYNWYKGSWKTGERDGIGIMNFGTDCGATYAGTWRKNFKHGPGLMVCGNGLVLESNPLFEFNKGVHKKHQISLSELCEKNVDTDYGQFIENKCSYQGILQLVNSEIAHSDFDDHLLANITHNSKNIPEHMFVNSIDNATGWCPLYIPTHCITEDVNLEYFVDIIFTYHVDNLRSDDYVKFMSNIVKNPSRTCQNIDIEDCDINNTSLEEKLKLAKNRELKKIRNTIILYLPKLKIIYERYSTCYEYLSEEPDVKLKFKPVLVRIFLWQFFRDIQIPENGIQLVDIDELLWKNPESCLSTAHYPFEPIYFYQFLMYLMGCTWLTFLTKYSGKFKVLTDSEYSYPSKIFRDFLDKKLESIVMMKDTAMLDHLHTAPLQSMYQTYTSIGEPMTIKAFLNATCTKDGEDPPCYYAINALTKTPTTPSIGFNAVPIAHQIMYLHDSEPIFGKKIEETEYREDKFYNTLYTFRVLGEKVILETISIICPTLGHIESSAMKYKITFLEFYEIVILLAYIKAENEMKKSQTATVKGSVAEVNYRQKIKRKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBP5</accession>
    <name>A0ABM5KBP5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="RefSeq" id="XP_050507610.1">
        <property type="nucleotide sequence ID" value="XM_050651653.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651653.1">
        <property type="protein sequence ID" value="XP_050507610.1"/>
        <property type="gene ID" value="LOC126885205"/>
    </dbReference>
    <dbReference type="GeneID" id="126885205"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="292"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="660"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="817" mass="92282" checksum="CE1B23020FCA35EC" modified="2025-10-08" version="1">METQDMDQHIRDIQREYLDFLDDEADQGKYSQLVKDMIDDKSYRLLVNINDLRRKNALRAAALLNNAFQEQMAFQKALKEYVLSVNPDYAKDHVDFFIAFEGSFGNKHVTPRTLVSRYLGNLICVEGIVTKCSLIYPKVVRSVHFCPDTKKIMERKYTDMTSFEAVPSVAVYPTKDDDGNPLETEYGLSSYKDHQTISIQEMPEKAPAGQLPRSVDIVCDNDLVDACKPGDRIQVVGTFRCLPNKQQNFSNCIFKTLVIANNISQISKDATHSITREDVAHCKKLAKTNKNIFNLLSKSLAPSIHGHEYIKKAVLCLLLGGVEKVLPNGTRLRGDINVLLIGDPSVAKSQLLRYVLHTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDVDRTAIHEVMEQGRVTIAKAGIHASLNARCSVLAAANPVYGKYDQYKTPMENIGLQDSLLSRFDCLFVMLDTVNEDQDLKISDHVVRMHRYRNPLEQDGEVLPMGSNVEMLSTMNPDEEDRKETPVYEEYNALLHGESRRRTDKILSVDFMRKYINFVRILKPILTEEASEIISDEYSRLRSEDVLESDVARTQPVTPRTLETMIRLATAHAKARMSKYVTAEDANDAIELIQYAYFKKVLEKEKKRRRRDEYDSADEEEDDQRQKRARPVRTDAGDDSDDEIIATQSSTRSRSTAVSGVEPMEEETVLNGVNGHTNGHMEDSESMEVDDSPKEISTDRLTTFKSSLQKAFRESRTQSLSLRRVREFINSDNPTPYTQNEISAAIERMTDDNQVMLADGFVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBU6</accession>
    <name>A0ABM5KBU6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507664.1">
        <property type="nucleotide sequence ID" value="XM_050651707.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651707.1">
        <property type="protein sequence ID" value="XP_050507664.1"/>
        <property type="gene ID" value="LOC126885238"/>
    </dbReference>
    <dbReference type="GeneID" id="126885238"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19058" checksum="219717870F7B2951" modified="2025-10-08" version="1">MDSDNLTHTKPLSTQTTSSTSSTITYSNAVTNFNFPTKQQAVVLSSVPDIKIHEYITAIGTIVQPKNIIFASRISNNRVCIYLSNTTIVENLLHNHKSVSIQGNDIEIRRLITPASRLVISGVCPSIPNTIIEEELKKLELTAVSKITFLKVGMPESEYSHILSFSLSQIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCI9</accession>
    <name>A0ABM5KCI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507895.1">
        <property type="nucleotide sequence ID" value="XM_050651938.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651938.1">
        <property type="protein sequence ID" value="XP_050507895.1"/>
        <property type="gene ID" value="LOC126885378"/>
    </dbReference>
    <dbReference type="GeneID" id="126885378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="128" mass="14917" checksum="4C6ECD6F80445BF6" modified="2025-10-08" version="1">MPSCAFPSCNYNARMNKENLTKISLHCFPKDVKRRKAWIQFVNKENWEPSKGSRLCTKHFAERDVDRTSLAYPIRLRENAIPTIGESQVLQMQENAKVRPILEYAGGTWYLDLIRDKTLLESVQRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCL8</accession>
    <name>A0ABM5KCL8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507920.1">
        <property type="nucleotide sequence ID" value="XM_050651963.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651963.1">
        <property type="protein sequence ID" value="XP_050507920.1"/>
        <property type="gene ID" value="LOC126885398"/>
    </dbReference>
    <dbReference type="GeneID" id="126885398"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="77469" checksum="6A8024860F89F0FB" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQSTVATAKVRLPEITMQTFCGSFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALRQFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFATHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQTPQNSQGASRFVAPISTQHSFNNRSQNEASTSSSRPPVDMQNFPDSQAATSLSALSVKTDVLLATALLQISTISENTSLSNEMLNLEFFPYNVNDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKIDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFAQSEPEENQLDKLLQQFFEIEEVPLVSKLTPDEELAEQIFSKTTLVLPSGRFQSTYLELLPDLRQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCM2</accession>
    <name>A0ABM5KCM2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507943.1">
        <property type="nucleotide sequence ID" value="XM_050651986.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651986.1">
        <property type="protein sequence ID" value="XP_050507943.1"/>
        <property type="gene ID" value="LOC126885417"/>
    </dbReference>
    <dbReference type="GeneID" id="126885417"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="54847" checksum="0BF9070774FCB1CF" modified="2025-10-08" version="1">MYYISILPVNKEKYISFTVYHKKTNIRFRFIDTFRFMGSSLDSLVSTLKPENFGILRKQFPNVDDETFKLLTKKGVFFYDYLDKIERLDERKLPNKEKFYNKLNDEHISDSNYAHAKLVWEKFNMKTLWDYSNLYMKTDILLLAVVFETFRDTCFKTYGLDPGHYYTIPGFTSTTMLKYTGCHLETIQDVDMLLFYERGIRGGISQCCNRMGEANNKYMMNYDPSKPSKYLMYLDVNNLYGWAMSEPLPYGGFHWDDTNIDVMSIPDDAKEGYILEVDLSYPENLHDYHKDLPFCVEHCKPPGSKQSKLLSTLYNKTNYVIHYRNLKQAISHGLVLTKIHKILRFKQMTWLKGYIALNTQLRAQAKTSFEKNLYKLMNNAVFGKTMKNQRKHRLVKLVNKWEGRVGARNLIASPKFHSRVIFDQSLMAVELKKAEIIFNKPLYVGMAILELSKTCIYEFHYDYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCZ2</accession>
    <name>A0ABM5KCZ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508045.1">
        <property type="nucleotide sequence ID" value="XM_050652088.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652088.1">
        <property type="protein sequence ID" value="XP_050508045.1"/>
        <property type="gene ID" value="LOC126885507"/>
    </dbReference>
    <dbReference type="GeneID" id="126885507"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="3">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="269" mass="30034" checksum="499150F7BB38DB63" modified="2025-10-08" version="1">MTDGNTSANTSASVDRISVKIPPFWPNDPEIWFLQVENQFTLANIKSDATKFNYIVANLDTAYILEVRDIIVSPPATERYAKLKSELIKRLSASQKQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPDNIVRSLWLGRLPASTQAILATQAKAGLDAVAELADTISEAIAPRAQISEASNALESAIEKMTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRGRPYPRDRSCSRERNSDICWYHYRFGDQAQKCSPPCKQQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEE6</accession>
    <name>A0ABM5KEE6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508564.1">
        <property type="nucleotide sequence ID" value="XM_050652607.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652607.1">
        <property type="protein sequence ID" value="XP_050508564.1"/>
        <property type="gene ID" value="LOC126885846"/>
    </dbReference>
    <dbReference type="GeneID" id="126885846"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="751" mass="86080" checksum="0BDE865E91662569" modified="2025-10-08" version="1">MASVTHKCVYAGCFERNDGTNNNISFFKFPLKDVERTKIWQKNCGNIDILLMDITDLIQRVICQHHFAVEHIYQSGQRKLLRKNAVPLKFTQLTTDLGDIPPVCSTYVYCGTKRKRSTSDDCMVRSTPSPKRSSSSLSDISSFEINLPTKLETELTEKVKKLEYQVNALKKKCRQKNSQRCRRTTKNKKSATKFMLQVLLENKSKYVHTFVNMQFSHKTRSQWSHNEKDLALAIYYKSPSCYKFLIRSLNFILPSVKTIQTWLRVIKLRTGLNTSLIDKLKKKAETMDELEKICVLMFDEISLKKKLEYNKLDDIIEGFQDLGALGRTNKLANTGLVFMMRGLLHNWKIPICYFVTGGPIHSDNLKNIVVEVVSKLQNIGYIPKVLVCDQASNNRALFKLLGACKDQPAIEIGNQRIFTVFDTPHLLKSLRNNFLNKKLTFFADSNQISWQDIEYTYNIDRTNVRARCMVKITDVHINPNNFQKMRVKLAAQIFSNSVASAISTAKSVGQLHTKTAPHTAEFLKIINNIFDGLNSKYCSDSNPNRKPMSTLSKSTENLKAGLEYFKKIKVFENQKERNNIHCLHGFQWTILSVLCLWEELQKYNVSYLLTSFLNQDPLENFFSIVRNRGGYNPTPSVSQLRIAIKHNTNIKLKIALDNGNCEIAQTDNLDLTHEVTSVEISDESIETQTVHVEQSLDMQEENNDNQILSTAHSSKCSITNLETCAVTYVAGYIYYKIIKNLNCEIMAQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF76</accession>
    <name>A0ABM5KF76_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508851.1">
        <property type="nucleotide sequence ID" value="XM_050652894.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652894.1">
        <property type="protein sequence ID" value="XP_050508851.1"/>
        <property type="gene ID" value="LOC126886052"/>
    </dbReference>
    <dbReference type="GeneID" id="126886052"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="165" mass="19479" checksum="23CCD96E41442B1B" modified="2025-10-08" version="1">MPRRKKGGDLASSAAKRRKKKEHRRNETEEEREARLQNQRTRMRTLRSTKNEERKENESIEESRILKDNLTKEAFHYEPTKKYYNHKHVVIGKMDNICQFCHAKKFSKETAGLCCMNGKIRLPPLEAPPQEFLHYMTGETQESKHFLQNIRLTSKNPASLTVSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFC9</accession>
    <name>A0ABM5KFC9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PFC0760c-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508890.1">
        <property type="nucleotide sequence ID" value="XM_050652933.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652933.1">
        <property type="protein sequence ID" value="XP_050508890.1"/>
        <property type="gene ID" value="LOC126886090"/>
    </dbReference>
    <dbReference type="GeneID" id="126886090"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF1">
        <property type="entry name" value="PROTEIN DEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30060" checksum="4925806B1B1E1F83" modified="2025-10-08" version="1">MQSKQTINDFPKISLNLKNSSLSAVKALHVVAYGDKGLPRQTRKNLRNFTNFAWDKGSQEYSTKIDDIKNKLSMPDLVAVCHVLVLNYTGSEDDVIERICSFLNDFNLEDETDDEDEDASDDNGDKDVYHNEEGKYVTDDDGDNEDNDVNSDKDEEGKDVTEDDGDNKDNDVNNDKDAYHEDEEESKDVTDDNSNHDDNRKDKRTTDLFTRNRSKSNNMTRGRLNDSFALTFRDVEELVESYEPFFNSFILQSISNDNKRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFW0</accession>
    <name>A0ABM5KFW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509075.1">
        <property type="nucleotide sequence ID" value="XM_050653118.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653118.1">
        <property type="protein sequence ID" value="XP_050509075.1"/>
        <property type="gene ID" value="LOC126886252"/>
    </dbReference>
    <dbReference type="GeneID" id="126886252"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="164" mass="18576" checksum="583AEB1AFA0420AC" modified="2025-10-08" version="1">MTDGNTSANTSASVDRISVKIPPFWPNDPETWFLQVENQFTLANITSDATKFNYIVANLDTAYILEIRDIIVSPPATERYVKLKSELIKRLSASQQQKIKRLLEHEKLGDRRSSQFLRYLQSLAGTTVPDNIVRSLWLGRLPSSTQAILATQDKASLDAVNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGS6</accession>
    <name>A0ABM5KGS6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509394.1">
        <property type="nucleotide sequence ID" value="XM_050653437.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653437.1">
        <property type="protein sequence ID" value="XP_050509394.1"/>
        <property type="gene ID" value="LOC126886477"/>
    </dbReference>
    <dbReference type="GeneID" id="126886477"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="557" mass="65292" checksum="BD17B9B0A7823307" modified="2025-10-08" version="1">MSQWADLGVNKSTFAIITSKILVVNEEILIKNGCCKIVFGRFKVCLDMLPLLLLVLVIFLLYCRAIQCLSYWKKRGVLQENPHKLLWNILRFRRKSEPSSSEFSSIYNLSRNVRYVGYYHFTTPILMIKDEWLLRNIAEMDAEYFYSPDQYVLKRDDPLCNINLRDPNWKVYLTNGDLRRMFPILEECCQNFSKNFMKNYVDIIDVRIKDTATSFVNDIIAFTVFDISLDPKDKANKKFCRMIRSITNSTICKSQKFWGHSFVSKILQFLNILYSIDSQPKQYFMDLLHDKLKSRAAKNSTRPDIIQLILETKYEKMQPTQNSTDRADNIEKSPLVPSSIKNSDILAHFLLYLLAGLEPVSNLISFVAIELALDKDIQSKLIKEVDNSFERCNGKMTYDILTKMKYLDMVISEALRKWPYFDTIYRICNQTYVIEPKTSKEKEVVLEKGSVLCIPVTPMHYSPRYYGYSRRFDPERFSSQHRCIIEPYTYLPFGLSEKGCMGSRFAVLQTKIFCVHLLHHFEISVSEATKLPLTLTKEKAHQYVLDRIRLSFERRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKX9</accession>
    <name>A0ABM5KKX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510855.1">
        <property type="nucleotide sequence ID" value="XM_050654898.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510857.1">
        <property type="nucleotide sequence ID" value="XM_050654900.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654898.1">
        <property type="protein sequence ID" value="XP_050510855.1"/>
        <property type="gene ID" value="LOC114339129"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654900.1">
        <property type="protein sequence ID" value="XP_050510857.1"/>
        <property type="gene ID" value="LOC114339129"/>
    </dbReference>
    <dbReference type="GeneID" id="114339129"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055577">
        <property type="entry name" value="DUF7153"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22198">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22198:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23672">
        <property type="entry name" value="DUF7153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7153" evidence="2">
        <location>
            <begin position="258"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="442" mass="49453" checksum="1F2E55F9907E525F" modified="2025-10-08" version="1">MNLMFRKTFGEQKTGTTTSKCTKSSAGRHTSKRSREQGYTAMEEHHYRTHLFFSPPRSSFGPGDDDGYHDPTGNAQRMQRAILHTEPRCGPMTGAGGEPLPMQSTISPAMTESDLPQPLVVRSPSVSLMKWPSQSPTKTTPTRQVNFNYGNEGSHADTQRTLSGLDRDCFIIPVHSLDRFLPAGVPMPKPVNNNSLEKKGNLHVMEVPDPKLCVLCHLMSPLEPVDPVLESPLVQPLLKQRVIAGELVNDIAQAKTAITGMLLANMERNGEFPFITYYVINTSQTNPVMFYNNLRTASLSKFDPRTTRYTAAHTLDLYTEVASICRPPVHEIGMSLLKTQSSSTGYMVSVYKVFEGDDREKFERNWLYWTGARMIYRYLPQAAGLRRISLHKSLSPKGDKMYILLCECANLLSDVTVCALILPALRARLTGYTGIFRPLQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMT0</accession>
    <name>A0ABM5KMT0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Coiled-coil domain-containing protein 135</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Coiled-coil domain-containing protein lobo homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511511.1">
        <property type="nucleotide sequence ID" value="XM_050655554.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655554.1">
        <property type="protein sequence ID" value="XP_050511511.1"/>
        <property type="gene ID" value="LOC114330866"/>
    </dbReference>
    <dbReference type="GeneID" id="114330866"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033551">
        <property type="entry name" value="DRC7/lobo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056292">
        <property type="entry name" value="DRC7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056291">
        <property type="entry name" value="MORN_DRC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35249:SF2">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24671">
        <property type="entry name" value="DRC7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24667">
        <property type="entry name" value="MORN_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="15">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 MORN" evidence="16">
        <location>
            <begin position="432"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex subunit 7 C-terminal" evidence="17">
        <location>
            <begin position="762"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="876" mass="103872" checksum="259568A16ACC84F1" modified="2025-10-08" version="1">MADYTTEPEKTVYDYLSVNAEDGEEVEEEEEFSYIRQLDKVRILPEPVDLTHEHLKEIGYELGLIKLCWPEVLEPFFEDRTNFPVRYVKNDEKEKLLLLYAENFRKQFCFKYPERKPLLLAVENECGILKMVCTTLRPTMLPHPELETWDGCASFIADHIKFEPNEDMPTFLPRRLYSPHTILLRQSGQSFEMATLLCSALIGVGYNAFVVSGYAIKDVTLRIMVRVDCPFPPFKEEEEKPEVKFIEEKYKLKPPRDLRSKFLMMMEKRETDKVLAQQAKIAEEEQRKRLEEEARPPDDLEGQRTHAWVIILPPNKQIQEPFFIEPSTGFSHPLTTDIYLGIESIWNHQNYYVNLQDCSEGLSNINFDLKENEKWIHFLIGEPPFEREHKPREIGEDDPEATEMLEEKHLDMPTSWSMKMNVPHEILKKRFPEGCRTTQFKRVFVEEYAPFTSCDGLVSRITRFQDFDCKIPEVIEEEFEYRHDKFVRSISKCDTNAITDYFDKGREDAVIKHIYIRNEDDVHAKRTIFFNHEGRYDALHKIEVDPNVITEHYKNRDDRLYYRQVTYETNEETSVKIGGVLRRPILKIIQKYERDESKPSYEDIAIREFAIVAREIRIKFHYGKNNVTASTRIYMKPPISEFGEEMVFDPELTYGYQAEIGLKRPRQLALYLMFEDQLKEEATVINNIRDVEAQISEFLLTRAREMAFSKLDVPLFNKEQNAEYRQAMLDKEKLARVYKEKEVEEEIDYFAPYLARFGNLRLTPKQAKEAREACLEEFKQLLVNRANNIQKTFDKMNERLQAKKLYYTTNHDILTEQEEACYFEEVNNIMLIMKTLQIRLNRHKELAAIRYQMMVDYLDKHPNLRTHSLSRRLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMW0</accession>
    <name>A0ABM5KMW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511519.1">
        <property type="nucleotide sequence ID" value="XM_050655562.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655562.1">
        <property type="protein sequence ID" value="XP_050511519.1"/>
        <property type="gene ID" value="LOC114328056"/>
    </dbReference>
    <dbReference type="GeneID" id="114328056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="64"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="191" mass="21669" checksum="FD262CD9D6891FF9" modified="2025-10-08" version="1">MSKMAFIPVVFGENYWAPHCPRRQVAVPHRKFVEGINHDVLNSIALAQALFGPEQDRADMVMRQNSRILNQGRSSVTIDEHKFQANFDVQHFKPEEITVKVNGDRSITIEAEHEEKQDEHGGIYRHFVRKYKLPENCDIEKVDSKLSSDGVLSITAPTIGQKSSSHRTIPIIQTGKPIKSAEKPQIEQKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP16</accession>
    <name>A0ABM5KP16_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050511940.1">
        <property type="nucleotide sequence ID" value="XM_050655983.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655983.1">
        <property type="protein sequence ID" value="XP_050511940.1"/>
        <property type="gene ID" value="LOC114327479"/>
    </dbReference>
    <dbReference type="GeneID" id="114327479"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14456">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007747">
        <property type="entry name" value="Menin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693:SF3">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05053">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="507"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="617" mass="68926" checksum="5FBB6F1261B8EA4D" modified="2025-10-08" version="1">MAGFRDIDKALFPIKSINTVVQLFRNQLEGLSDPDLALLSIVAGIIENSLTSRSNGALQVCEPVEQNNLPILEVKAVELLYNKFKSIMTNAVDQNKSKSFATRELVKKVSDVIWNSLTRSYYKDRAHLQSLYSYLSGSKLDCFGVAFAVVAGCQCLGYNDVHLALSEDHAWVVFGENGTETAEVTWHGKGNEDKRGQEIGKGVSARSWLYVNNKPVVCTRHMEVAALVSAINPSLNSTHDAYEVALLQQELLWLLYDLGHLKKYPMAIGNLGDLEEISATEGKVPCKLLFEEAIFSARNYYNNQHVYPYTYQGGYFYRNKMYEEAFESWANASDVIRLYNYSRDDEEIYKEFLEIANELIPHIMKIESSGFSANTILKKPKCFADLLRFYDGICQWEEGSATPVLHIGWAKPLVLTISKFDADVRAQVNIVCDKSEEDKILKKNGTYFNNNNYEKENGSTNNDHSIPSTAKPTAEVDKSPFHPSIEALTAACSEKILNPEYLLQGDGSPFVGGDYPDPAPINTPSESEEKINGRPSTSKQDPLGSPSSSTEEPPPQDTRPTIVLHSQKMKQLKDLLLAEKLNTQAISLHLTAQSQVQIGKKGRGDGDNIRPKRARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPG3</accession>
    <name>A0ABM5KPG3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512079.1">
        <property type="nucleotide sequence ID" value="XM_050656122.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656122.1">
        <property type="protein sequence ID" value="XP_050512079.1"/>
        <property type="gene ID" value="LOC126888099"/>
    </dbReference>
    <dbReference type="GeneID" id="126888099"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35407" checksum="19E2F1493765616B" modified="2025-10-08" version="1">MPICVLCTQGVTGKSPGLKCCGGCQEFYHAKCVGLTKSDVSRFQTPGLSWTCTNCRGTVDKRRSVIVADEDSDDFPLEETSSSQTLKVLHSIQKDMASMNIKYGDLLQSVNFCSDSITTFENTISILTNKIKEIEKLTKENLNLRDEVKVLNSRVDTLEQQLRANDVEICGVPFIDNENVLKIVSEIGSAIDLPITEGDVDSFYRSSTFRTDLPNPIIVKFSKKIKKDAFLAAAKAKRRQNGSFRGLKIANISDQLYVNEHLTPKNKKLLRDTKLAAKSKQYKYIWTRNCVIFVRKDDRSQIIKISCDGDIEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPJ1</accession>
    <name>A0ABM5KPJ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512103.1">
        <property type="nucleotide sequence ID" value="XM_050656146.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656146.1">
        <property type="protein sequence ID" value="XP_050512103.1"/>
        <property type="gene ID" value="LOC126888143"/>
    </dbReference>
    <dbReference type="GeneID" id="126888143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="283" mass="32370" checksum="3291DA6FD7BE6850" modified="2025-10-08" version="1">MINVEFPNLFQNCKAYAKKVIQYIPVLGWAWKCSEFVFLERNFDKDRKVINKQITELAEHPDPIWLLLFPEGTRFTKKKHEASVEFAAKHNLPLLKHHLLPRTKGFIASLPSMKGKVPAIYNIEVAFREDAPYKPTITTMLLGKPTTAHIYFQRIPLEEVPDNSAAQESFLRDIFIEKDKIKESFINTGDFFETSGVARVDSFVVKPRLHSIFNFIFWILITLVPMSYYLMKLLFSGELVYFSIGAGILGAFYILMCKTIGMTEIDKGSSYGVGAETPPKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPU8</accession>
    <name>A0ABM5KPU8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor Adf-1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512218.1">
        <property type="nucleotide sequence ID" value="XM_050656261.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656261.1">
        <property type="protein sequence ID" value="XP_050512218.1"/>
        <property type="gene ID" value="LOC126888207"/>
    </dbReference>
    <dbReference type="GeneID" id="126888207"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF69">
        <property type="entry name" value="SI:CH73-59F11.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33430" checksum="62FA424DDB2FBE70" modified="2025-10-08" version="1">MDVCDSDALINAMKSQDIIWNYKQLDYINKINRNSAWTIICSQVVANFDELTVQEQNKIVTLVQKKWKVLRDGYTRYAKKIKSKSGSSAPKWPYQYYDQMSFLRAVREDKPDETNSLEESEYAEIITMYEDSDFPESMLEESGYAEMKTEESENENKKCQSRSQNAEKQTSNYKIKLNNAMKEDIIPEKLSKRFEEKSQNSSNAEEHDKFFLLSLVGDFKKINDQHKLDAKLEILNVIKHYQGMSHHINPSSYSDKGYSTQHSSLPNSAPRSYSTGPSTSSVDDAEDPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ49</accession>
    <name>A0ABM5KQ49_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EFHB C-terminal EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512314.1">
        <property type="nucleotide sequence ID" value="XM_050656357.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656357.1">
        <property type="protein sequence ID" value="XP_050512314.1"/>
        <property type="gene ID" value="LOC114328339"/>
    </dbReference>
    <dbReference type="GeneID" id="114328339"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057428">
        <property type="entry name" value="EFHB_EF-hand_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF12">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING FAMILY MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25325">
        <property type="entry name" value="EF-hand_EFHB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EFHB C-terminal EF-hand" evidence="7">
        <location>
            <begin position="449"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="533" mass="61552" checksum="8FC43DD12F8F465E" modified="2025-10-08" version="1">MGSNKGRFVDRSPIICPAGKVTTDPNNVANTLRQYTVEDKIDALKHTANIWHDEAAFEPPLKAPNFVQNSYIRQNREISSLLNPPVETRYQTLLRDLQETTYDSFWNKEIGKTRDSVPGLPKGTIPTEVTYGNPTIKESSVKELVNPPKTPYEVLWNSQIGHDKYIKTHNDYNPGEKLHRGYVSPPFDEKACFGKKTWYDYRGVWVKCCCQWHIQKPITSVNKIQADHLERVKPVVGKPLTPNHNIDCVPKNHAFGKRYIRDKYGVEDLLKDPNLEPCLFKRDFYVLMHMWNKLRSNMKELVRQGAFNFSEFYKRLLYFDKERNGMLPKDIFYEVCLSSHVKFSMTDMEQLLKLLNIMSDDQINYKRFVDMINVNAPTIELMSTKDIPPEKLYYITTNQAAGCDYLFINNANMPTAGIPTHRTDLPAPYQPAGSCLADLESLGDSTNIKTLLNPSIYTNYGLNFRDFFLPRQPDVLKTLFEKVGYCFPGDKFEKIWKEGVEQDETGLVCVDTFKKLLEKYTPIQKIRVDEADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS88</accession>
    <name>A0ABM5KS88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513054.1">
        <property type="nucleotide sequence ID" value="XM_050657097.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657097.1">
        <property type="protein sequence ID" value="XP_050513054.1"/>
        <property type="gene ID" value="LOC126888715"/>
    </dbReference>
    <dbReference type="GeneID" id="126888715"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21576" checksum="30F680247FA2F281" modified="2025-10-08" version="1">MDETYVHSSHTYQKSWSDSSNKGIQKPVSKGQMLVIVHAGGESGFVKIAYLRYKPTIKTGDYHDTMNYDNYKKWLQDKLIPNLPPNSVLVIDNAPYHNVQTEKCPTMSSRKAEMQQWLTTRNISFTDDMLKFELYDIIKLHKPLFKTYEIDKILEDKGHSVLRLPKILSGFESYRVSMGSYEAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KU94</accession>
    <name>A0ABM5KU94_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513757.1">
        <property type="nucleotide sequence ID" value="XM_050657800.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657800.1">
        <property type="protein sequence ID" value="XP_050513757.1"/>
        <property type="gene ID" value="LOC126889477"/>
    </dbReference>
    <dbReference type="GeneID" id="126889477"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF9">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="6">
        <location>
            <begin position="423"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="64514" checksum="EC87CF6965E39BDB" modified="2025-10-08" version="1">MLSSAQLLNMTIVNLSMSSLRKRNCFFVFIFIVFVPFCLFVILSVPDISSEETLLQRLAELQVRIQYLDAMYRSRQEELQELTQHIDQIYNEDSTLNSSANVQELRPDIKQMLKNMSGLYAANGLNPGVSVKFPSAFHFLPHLLDNPNSLKLAYLMSKNREGVSLVLGIPTVKREKYSYLMDTLQNLIDGLSPEEANDTIIVILIAETAMEYILQIAKEVEMKFPSQVESGLIEIIAPSSGYYPNFDKLRITLGDSSERVKWRSKQNLDYAFLMSYCQTKGTFYVQLEDDILAKPSYATIMRKFAIEKTAKKDPWIVLDFCQLGFIGKLFKTAELPWLINFFQMFFNDKPVDWLLDYLITTKICNWEKNDNCKADKAKVWIHYKPSLFQHIGMHSSLKGKVQKLKDKQFGKVALFFPHNNPPAEVVSGIKHYKQYTLKRAYLGETFFWGLLPQPGDQLLFNLTPPVTLKRFYFRSGNAEHPTDKFYNTTVEVKPVQPIQNLNFSNVTQDGFIIIGKFDSAGIASGSLNNSIGKISSLRLNVHSESDNWAILSEIHLQDDSRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV98</accession>
    <name>A0ABM5KV98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514114.1">
        <property type="nucleotide sequence ID" value="XM_050658157.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658157.1">
        <property type="protein sequence ID" value="XP_050514114.1"/>
        <property type="gene ID" value="LOC126889652"/>
    </dbReference>
    <dbReference type="GeneID" id="126889652"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="546" mass="64241" checksum="0B633762441FA6DF" modified="2025-10-08" version="1">MEVKQEISEETCKVEIEYNGLDDALLDDFNCEIKEEEEESNGQSTHDTSDYLDLKESPIKTEIEQDENTLNPFEETKTTKEGYLHQRENKMEIMETLIGHSSSKGNYTSPHDEGKTINQDTKVAAGRRYYKCEICFKPFTKAHYLKGHLRVHTGEQPYKCEICFKQFTTAQMLKYHIRTHTGEKPYECEICFKQFNQAGHVKKHLRVHTSETPYKCEICFKQFQQKGNLNTHLRLHTGEKRYKCEICFKHFSGNLKRHLRVHTGETPYKCEICFKQFSTAGDLKKHLRVHTGEKPYKCELCFKQFTKAHYLKGHLRVHTGEQPYKCEICFKQFTTAQMLKYHIRTHTGEKPYECEICFKQFQQKGNLNTHLRLHTGEKRYKCEICFKHFSGNLKRHLRVHTGETPYKCEICFKQFSAAGDLKKHLRVHTGEKPYKCELCFKQFTTAHYLKGHLGVHTGEQPYKCEICFKQFTTAQTLKYHIRTHTGEKPYKCETCLKQFITASNLKKHLRVHTGEKPHQCEICLKKFAGNLKKHLRTHTGEKPYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW91</accession>
    <name>A0ABM5KW91_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">F-spondin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514449.1">
        <property type="nucleotide sequence ID" value="XM_050658492.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658492.1">
        <property type="protein sequence ID" value="XP_050514449.1"/>
        <property type="gene ID" value="LOC114334145"/>
    </dbReference>
    <dbReference type="GeneID" id="114334145"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047001622" description="Spondin-1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="9">
        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="10">
        <location>
            <begin position="190"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="642"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="734" mass="83672" checksum="5BF1EB49C308D4B2" modified="2025-10-08" version="1">MILFHLIRFVTVWVIFFCHETTSSNIGLRCDMIPEGVTSLKNKDNHNRYKIEISGNPEFYIPGEQYTVLLKSNTKSNGSLHRFTHFILSFTNEKFAKNIESESSVIGAVQLYGDTMTKFSDSCQNAIIQADSQPKTEIQILWMAPTKVNGCIKIRATVVESVDVWFSENGELTKILCAESPDSDDIQPKILKHCCTCDEAKYEVIFEGLWSRNTHPKDFPLEGXLTRFSDIIGASHTVNYTFWNYGGIASEGLRQLAEHGNTKMLESELKSKSDHIRTIIKARGVSYPNITGKTFAVFRVDNRHHLMSMVSMIDPSPDWIVGVSGLELCLRNCTWIESKVLNLYPWDIGTDDGLTYMSPDQPSSPRQQIRRLKTNFPTDPRSPFYDNTGQSMKPFARLTISRQRLYEKICDSAAMDDVDDNSNNCETESWSDWSPCSVTCGRGVKYKQRKYKNEESKYNCHRKLTERASCEAVQTYCRIAPIREKVDPMCELGPWLEWSSCSVTCGKGTKTRERRFKNRLAAKTCMAGKTKPPLLQQNLECEGEGKCDRRMPNVVENCYDIIWTEWSPCSATCGKGFKERYRFPSRTDSNKQFYPLSEYYKKKFSERKQNSRDPCSNVIRETVECVEKVCQEENRQYNEMACGLPKDIGGCKSNVDRWYFDIIKGECSIFTYSGCGGNMNNFNTLEQCQTLCAKFKKELISTSIVKKKELGVSVSGVLSYGLHHKAGEKLCGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWJ4</accession>
    <name>A0ABM5KWJ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514561.1">
        <property type="nucleotide sequence ID" value="XM_050658604.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658604.1">
        <property type="protein sequence ID" value="XP_050514561.1"/>
        <property type="gene ID" value="LOC114336592"/>
    </dbReference>
    <dbReference type="GeneID" id="114336592"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005445">
        <property type="entry name" value="VDCC_T_a1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF230">
        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01629">
        <property type="entry name" value="TVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1356"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1395"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1555"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1635"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1664"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1698"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1767"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1855"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="96"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="694"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="1633"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1168"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1968"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2003"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1587"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2003"/>
            <end position="2028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2086" mass="238400" checksum="EE919AF26D57F6B5" modified="2025-10-08" version="1">MHCYSSSGALLSNASYIHCRSDSDSRLYRRGSRWELSESGESTVSDLDETESGTTSESAANIDPNIPYPGIAPVTLRYLSQTTRPRSWCLALVSSSWFERVSMIVILLNCFTLGMYQPCSDKDPCTTNKCLILQRFDEFIFAFFSLEMTIKMIAMGVYGPGSYLADSWNRLDLFIVIAGAVEYGLPNFINFSAIRTIRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWQGILRQRCVLNRVEFPTVDFPEDLIYFYKPVDSDYICSKSHNSGMHFCANLPNYKNGNIACTLTYEEKNYPQYSDNDSYCVNWNQYYTLCSDKNHNPFQDTISFDNIGLAWIAIFLVISLEGWTEIMYYIQDGHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRLERARFQSSSTLASSTNNSEPSSCYAEIIKYIAHLWRRSKRKVLIKIRFYILRRNQRSQLIAGDTIRLNYGKQHHPNCSKLTLISSANLLSPASVSSNTRRSSVMFSDLIILHGQNSSTTAYKKNVCSSEKTTQAGDGNIWQIATASDQPDIQTQQIQQQCNNLMNGETLTCQELLALGAINAALSTGQILLDIFFNSITKGIKKDSENNYLQHVSDDNFSCCQDLWQCEVEYKTEKRTKLYIYCCLVLKGILKAFKVFRKKIKKIVVHKCFQEGILVAILINTLSMGIEHHNQAEILTHIVEVTNIIFSAIFGVEMLLKIIAEGPFGYISNGFNVFDGIIVVLSAVELFRNCTSDLHTDSGLSVLRTFRLLRILKLVRFMPNLRRQLFVMLRTMDNVAIFFSLLILFIFIFSILGMYLFGGKFCVYVDDYGSTKECTCESMDNIRCRCDRKHFNNILWATVTVFQILTQEDWNIVLSNGMAKTSNWAALYFVALMTFGNYVLFNLLVAILVEGFSSERNERREREQRELAKRKMSCIIEASLRRNCGDSNYSLSSSSENCFPEYKNYWKPDEARNVKNLNQHAASCDFKDIHLNGNYPFRYRDPKSNIQKESLARLPIKRSSPPIITHTAATPQDSPSMTLKEFSEFQFQVNNSISTKEGTQPSVNVITQKIENSKLLVPPKLSPPPSTFRQFKHSSVDDSNSRVCKIVTYNEKSGPNTVTYSEKVGPAFCTGSTKHLASRSSWEGPRKVATKSSFKKSKNVSEVPAENIPLNNGRHHSQCSGKGQSPIPAHLRRKNYFKKTSIQENQVSKNSNVHAKKNNTNTIKFVNKSNEKILPQLSIDKGIKARIKKKISSVFQTADFLKNREDYSLYLFSPDNKFRKYCCWVVKQAWFDNLVLIFIAQNCITLAMERPNIPPDSPEKIFLQCSNYIFSIVFATEMFIKVVASGMCYGPNAYFTSGWNVMDGSLVIISVVDIIMFLINDTTSRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGSFYYCVAENLTGIETKDDCIAKGYNWKNQKYNFDDLVQALMSLFVLSSRDGWVNIMYTGLDAVGVDRQPKVNYSEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQEKEEKIRKAAKRALQMEKRRRKMNELPYYIDYPPWRLEIHKIVTSKYFDLAIALVIGLNVITMATERYHMPDYWEYALRIFNYFFTAVFILESTMKLVALGIKIYVKDKWNLLDVAIVILSVVGIVIEEIVQDLKIIPINPTIIRVLRVMRIARVLKLLKMAKGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVELFGRLDCSCTPCQGLGEHAHFQNFGMAFLTLFRVATGDNWNGIMKDTLDDEHCDHGDDCINNCCISPIIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQLEDEHDMDVQLEREFVEKQERNARELYLALQADQECQAQQKKTLVKVMSLPSDFTYTPPGTKVTLKIENPIINENISVIQSSPSPSPSRKNLKSPDESMADIYSIGSVSEEIKRDKGYQQNPDKDIFLKDEHKNKPKVEQNPSFLMVPQEREVLLQRSGSVKNLLRKQLSMDISEESAVLLSIPSIPKVQKRQKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY10</accession>
    <name>A0ABM5KY10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515079.1">
        <property type="nucleotide sequence ID" value="XM_050659122.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659122.1">
        <property type="protein sequence ID" value="XP_050515079.1"/>
        <property type="gene ID" value="LOC126890264"/>
    </dbReference>
    <dbReference type="GeneID" id="126890264"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1518"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="858"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="870"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1074"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1577" mass="177084" checksum="A8637FB64C11968B" modified="2025-10-08" version="1">MFCVIRGVNDCGDKSDEQDCANHVKLDQCTLDNKKFLCSNNKTCIDIHSVCDNKLDCPDYSDEGKQCSSSAISCNNNKCSHTCISLPTGPKCLCPNGYHTLDDSNCLDINECTTYGFCDQKCRNLPGSYQCYCDDKYTLQADKKTCKATGKSAIMVFSSKQEIRALTLDSLDYFTVAKDLRQVVGIAYDGNHIYWTDIFTGHESISRSLEDGSNREVLVTSGLSLPEDLAYDWLTGNIYFTDALKQHIGVCSNNGHHCTVLVNKDIRKPRGIVVNVEAGDMYWSDWGVPAAIGYSLMDGSRDRPFVTNNIHWPNGLALDQPNSRLYWTDAKKMTLESINLDGTDQRIVLEGIVKHPYAIAVFENKLYWSDWDSHTIQTCDKFNGKNHRTLVEEHKNLIYGISIFHYALKKRLVNPCEHASCSDICLLKAQSYACACPENKVLDTDGHTCKEVQPTQELVGGTGHVLVSIKHQFLGKHDVTFLPDLVKHVGSLAFDSYKNILYVSDLETKCIVALNMNVGVSKTLEIDGLGRVTSMDFDPKSNNLYICDTERLVVEIIDMNNLERKIIVHDTFGESPESIALVPEDGIMFVSFKQGKLGNSHIDRFFMDGTGRTHVIENNLVGPVRVVYDHSLYRIFFADLSTGVIESTNSAGDDRHHIRTLTTHPVSIAVLKDDLLWTNLDSKDLNWSEKRSSESHQKKITLGFKEDNVNIHLVSVTRKQLEINSCRVNNNGCSHLCLQSHKSIICACPAGWELSANGFTCNKRLTCDNKKMLCPHSNTCVLKNLRCNGFKDCAFGEDEWDCQTVSQCLPGQYKCDDGQCISEDLVCNHSYDCKDKSDEYGCADKNKKLGCPPRHFTCKSSECISERFVCDNFHDCDDGSDELNCENNICLESQFRCDVGTCIPKDWECDGEYDCTDSSDEHCSSEVCQSNYFKCDNNRCIDPKLQCDGFDDCGDHSDEKFEKCLHHLRAPKCTFEEFACSTNTSICFPKSAKCNGTSECPNKEDEKDCSKCEEDEFECKNKHYRECIPRSWMCDGTDDCGDNSDESMETCSSRLKTVVNTTGVADSCLTGYRCHSGACINMTSVCNNKHDCFDGSDEDGLCSSSCIGVKNSCNQICVKTPSGPRCECKPGYKLLGDGKTCIDDNECQTDPPICSQLCHNKEGGYSCDCYNNFLLSSNKKSCKAHGPRMTIYLVIYGNQIRHLIPKSNTMAVLYTNPMLKISSLDTLVKPGLIFFSSYETQAIYKLDTNTNMMHYIRNVGFPRKIAVDWSTQNIYYFDTDINGRSISICSFEEKCAKLINIESSRDVTALAVDSVNKLLFYVLRNSWVLETPSFVIYSVNLDGSNRQEIVKTTTGNVEDITFDINKKLLYYTNKQDGSIYEVSYKAESVKPVFSNISQPEGLKFFENQLYYTAATGYIVSCKLYGDKSCSPRYKLHTFASGQFVIEQESLQLKIKNVCTRHKCPYLCVPAETGYRCLCHDGKVSNHSEICGENDGNQSGNNNKFAVHTTPIQTASDKYSGAVVSAILVPLLLVFFGAVFYYLLKKKRHTSLNIRMRFQNLLYEKPVEDQYTTSTQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ52</accession>
    <name>A0ABM5KZ52_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050515469.1">
        <property type="nucleotide sequence ID" value="XM_050659512.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659512.1">
        <property type="protein sequence ID" value="XP_050515469.1"/>
        <property type="gene ID" value="LOC126890515"/>
    </dbReference>
    <dbReference type="GeneID" id="126890515"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18051">
        <property type="entry name" value="DEADc_DDX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="282"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="479"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="731" mass="81953" checksum="7D5180D712EEF258" modified="2025-10-08" version="1">MSNAPNQNGSGLEQQFAGLDLQSRSSNSSGRYVPPHLRNKQSQQQSPSTDNFDKDRYDNRDRFDNRDRDRDRGAPDSRDRGGSRGSNRGFGGGSGRDNRDSRENRDSRDSRDSRSGDFSSFNTRNRRDYQNGESFERNEWGSSRNNDRDRDRNADVQPRNDRWQEPERPARGSESRDGGSGGRWNDNGGGGGRWSENRRNVSSENDWTVPLSRDERVEQELFGTGNTGINFSKYEDIPVEATGDKVPRHITSFEEVQLTEIIRSNITMARYDSPTPVQKYAIPIIISKRDVMACAQTGSGKTAAFLVPILNQMFENGPPNIQQGRSRRKQFPLGLVLAPTRELATQIYDESKKFSYRSRVRPCVVYGGAHIGDQMRELDRGCHLLVATPGRLLDMIERGRIGLDYCRYLVLDEADRMLDMGFEVQIRRIVEKETMPKTGERQTLMFSATFPSPIQMLARDFLDNYIFLAVGRVGSTSENITQKVVWVEEHDKRSFLLDLLNVADLQQPSPESLTLVFVETKKGADSLEEFLHIEGYPVTSIHGDRSQREREDALRQFRSGNTPILVATAVAARGLDIPHVKHVINFDLPSDIEEYVHRIGRTGRMGNLGLATSFFNDRNRNLASGLLDILIEAKQEFPSWLEGVAADGRAPSANRRGGKGRYGSGGGSFGSRDYRQTSGGGSQRGQRSGGSGYGNNGYGNGGSHYGGMDRGSNFGGNYSNSTNRDDWWEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZE8</accession>
    <name>A0ABM5KZE8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515563.1">
        <property type="nucleotide sequence ID" value="XM_050659606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515564.1">
        <property type="nucleotide sequence ID" value="XM_050659607.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659606.1">
        <property type="protein sequence ID" value="XP_050515563.1"/>
        <property type="gene ID" value="LOC126890563"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659607.1">
        <property type="protein sequence ID" value="XP_050515564.1"/>
        <property type="gene ID" value="LOC126890563"/>
    </dbReference>
    <dbReference type="GeneID" id="126890563"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="364" mass="45380" checksum="7E64DE7DF33FCF27" modified="2025-10-08" version="1">MKINVKRNKPWKKHQRKWIKIRKKHQRKWIKWRKKWMTINRKEKQVTENRTQQNVGERREMVIHSTDDVKIRFGGDVRRLHPVPFINSLKKKIQHIGNFETAKETIRNHLKNEASLWFDCKEEEFDSWQEFEQKFLNYFWGKVQQLEINKELQNGKYNDRMGISERTYALQIYYNAKHLQYNYSSEQLVELIARHFEETLEDHITLQNYKDIDSLCQFLQIRELRLRERKSRRSREDYRPRETQEYRDRNENRRDDTRRDFNPRRENENRDNGRGNYEQRKRQWNEDRNREYQNRNTTRSNQENRNNGRQNEQGYRENRNRSDRPRENRREVNNTQTDEYDGERHYDENINNDEQPAFFHDGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZH5</accession>
    <name>A0ABM5KZH5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515593.1">
        <property type="nucleotide sequence ID" value="XM_050659636.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659636.1">
        <property type="protein sequence ID" value="XP_050515593.1"/>
        <property type="gene ID" value="LOC114325648"/>
    </dbReference>
    <dbReference type="GeneID" id="114325648"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="642" mass="73767" checksum="C305BFD875D3F68B" modified="2025-10-08" version="1">MDNTVNVSDCCRTCLRIDCALTSTELQDTDSVSFYDKLLACVSEVTWLKERVASLICSVCIERLRVAYDFRIVCLQSDATINRYLCIQDDSKQQGTSIETRTLSTPTKFEFSIATTAASETTALLTEDHQNSEYIHLKHFLDSDEVLMKQDDLIKNEVKHCEERTASPQNAATSIEFISKTEDRNIAESQPQQAILLQEEHHCQTEPQIHYEIPDQESHPDIQMIHQSLQTEEIEQQLEIESSEQVEQNGELHNIVIAPIQTIHQPDLSPPNYVALPYRQVIKRTTGVQVTPHIVKTESNEESATSGYPCKECGKSYKKKSNLRIHMRTHTGEKPFECQYCVKRFYHSSHLREHVRRHTGEKPYQCAVCNKRFTIKGELTMHMKSHTGEKPYACTCCDRRCLTSADLKVHMRTHTGEKPYECTVCNKRFASTYILNSHIKTHTGERPYSCNICEKTFTQSSHLNVHIRKHTGEKFTCKICDTKFTHSSQLTVHMREHTGRQPYKCSVCNKVCNYASELSSHMMKHTGEKLSCVTCDKKFTSAAYLAEHTRTHTGENLSRCTICNKPFTRSQYLLKHMRTHTGEKPYPCFVCGKKFTQSSSLKVHMRIHTGERPYSCSMCDKKFTTSSDLSVHNKKHKKYIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0J9</accession>
    <name>A0ABM5L0J9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MEIOB-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MEIOB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515965.1">
        <property type="nucleotide sequence ID" value="XM_050660008.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660008.1">
        <property type="protein sequence ID" value="XP_050515965.1"/>
        <property type="gene ID" value="LOC126890816"/>
    </dbReference>
    <dbReference type="GeneID" id="126890816"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056880">
        <property type="entry name" value="OB_MEIOB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24903">
        <property type="entry name" value="OB_MEIOB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIOB-like N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="465" mass="52746" checksum="EF1C4DD2E673FF19" modified="2025-10-08" version="1">MELDMPVVALRKTRLTDLNPNLTNILIVGIIIKKDKPRRFRDSSSCVEGMFRAVWNFTIRDSLKDYINVTYWSSSEAIYQMNNIFRTGDVVEVINPSIKIRSLGTNGERFRPMVTSPYSLTLSEQSTLLRHAGILTPYLELLNLPTQPLASFVPIRDIHNRGASINEANILVVVKGLNEIRTNISKNTNETYTVRTVEVFDHSSPNLRIDIWDSDIIQRSEHWKPRLTVLFMADVRIKWSDFDKQFQASVAGRTIVTENPKGKEVDLLLNYAKDAPIETFAIVNQIITALPDPNSIRDVMSVRQVHDTLRTFNGGVRQFTAVLYAFVYALDLDGLSKTLLIKCGRCKLEMKSSSCENSECSAFMETTPVEPEIQFDIRITLTDHTGSLKNCRFGGTVAEKALGCTAREFSNMSDDEKRILKWKYLLERCAIHIAVVYIGRGFPVITVLNLRLANLLEVSQKLAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1T8</accession>
    <name>A0ABM5L1T8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516404.1">
        <property type="nucleotide sequence ID" value="XM_050660447.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660447.1">
        <property type="protein sequence ID" value="XP_050516404.1"/>
        <property type="gene ID" value="LOC126891267"/>
    </dbReference>
    <dbReference type="GeneID" id="126891267"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033547">
        <property type="entry name" value="transpos_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISXO2-like transposase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="306" mass="35480" checksum="6888C7F3DDBB9F83" modified="2025-10-08" version="1">MACVEPCSIGVFEGGYMAKTKDEVPKFFVNHKVLKDVIVCRYGNTLKMDGKMTFRCNKMVLRKKRGPKKCGFCISARKGTFHENSKLAIDKIFLLVNLLLNWGPPRQEAALEELGISSSAMVDWYSYCREVFISFAINNSTKLGGPGSIIEIDEAKFGKRKFNRSRLFRCQWLFGGYERSTGNFFVIPVERRDADTLLGIIRDWILPGTTIYSDCWKAYNCLAHEGFHHQTVNHSKHFVDPETGTHSNHIERLWREVRSNIPKYGVKEAHFVGYLAEFYFKRRYTKRLERMHHFFKAASELYPPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L275</accession>
    <name>A0ABM5L275_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516546.1">
        <property type="nucleotide sequence ID" value="XM_050660589.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660589.1">
        <property type="protein sequence ID" value="XP_050516546.1"/>
        <property type="gene ID" value="LOC126891416"/>
    </dbReference>
    <dbReference type="GeneID" id="126891416"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31494" checksum="ECC4CD3D8902C401" modified="2025-10-08" version="1">MRERQQISHCSAFSLSDLGGDDKGTAQLLPMGSRSKLMLELVAQKNDDDFRNSDHIVNENIESINETRSYSNEKQETTQNNQEISQHHHQRTESTSSSSSRSSSGSSSSSFYEDSDDSVKDPDYQDPTLLPENLSLSVFEHLNSSPSVFEHLSSSPSAFVYENLSASIFEQENLLSDIEHESSTPPLTEHENSTPPLSEQQNLIPTETGIVVIETPTKKGKKRLRQESSWKKNVAKKLRNSGKSYQSSKSKKEMPERKLKPPCKEICKFKCRYNITETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2R1</accession>
    <name>A0ABM5L2R1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516723.1">
        <property type="nucleotide sequence ID" value="XM_050660766.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660766.1">
        <property type="protein sequence ID" value="XP_050516723.1"/>
        <property type="gene ID" value="LOC126891588"/>
    </dbReference>
    <dbReference type="GeneID" id="126891588"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25457" checksum="D5E5E751554F3BC0" modified="2025-10-08" version="1">MAQFVTHIQPTLVESSHHHLPHHHHKEHHKEHHKDHHKEHHKDHHKDHHGKDHGKDHGKDHGKEKDHHPSTKSPYKPDHHPHEYYPGGHHNFPVLPHVPFDHHHEDHYHHNGGSKRDSDHYEHGGSHGSSKRDSGHYLDSHGIPHQFELHFIDSQGIHRDYHGHAIEEDHHGEKEKHHKKNDKSPYREEGGRPTPPQFIDIQPIHLENKLHVSTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5H2</accession>
    <name>A0ABM5L5H2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517684.1">
        <property type="nucleotide sequence ID" value="XM_050661727.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661727.1">
        <property type="protein sequence ID" value="XP_050517684.1"/>
        <property type="gene ID" value="LOC126892225"/>
    </dbReference>
    <dbReference type="GeneID" id="126892225"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="272" mass="31211" checksum="6948085F34B8B4DF" modified="2025-10-08" version="1">MDAIIKTGFKKINHRITFQPNTESKGKALVLASHVKNVEELRKNGQSNLIQARIIRQTSVTSEPYYAKLYIDDKRLITDVYCNCVYNQSKKCKHVAALIYFVNHEESLTKTDHEQQWGKPSISQISKEKYSKGKFFYEMRMNAKKPKSISKSCDDIDTILTLKNPSPLKLICASMNLDDSKHVIADLLTEITKGVETNLKLEECHVCIENLLLFAAEYPVCLIELDIPNNLKDFYKNHIFLCSEDILKLSCDTLGQAKDKNWFLSRKKKNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L917</accession>
    <name>A0ABM5L917_DIAVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518933.1">
        <property type="nucleotide sequence ID" value="XM_050662976.1"/>
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        <property type="protein sequence ID" value="XP_050518933.1"/>
        <property type="gene ID" value="LOC126893035"/>
    </dbReference>
    <dbReference type="GeneID" id="126893035"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF19">
        <property type="entry name" value="LOW QUALITY PROTEIN: ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="208" mass="23975" checksum="447CAFC4CA05096D" modified="2025-10-08" version="1">MIRTAKLENQAREIVSAFGVKLQYWSQKVEQNKIASFTRLALCLEDGENITFADIKDTLVRYLINLRKRFSDYFPDLDTRTVSWIVDPFKCEIAMIPEEPSGLAEAILELRSNIEARIQFESKPNLSSFWMSKAAKAFKIAHEEAVKKLLPFGITYLCEQGFFTLMNIKTKNRNRLNAEDCIQIALTSKNPNFEAIVSNMKQHHFSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAB5</accession>
    <name>A0ABM5LAB5_DIAVI</name>
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        <recommendedName>
            <fullName evidence="13">Twitchin</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
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        <property type="nucleotide sequence ID" value="XM_050663423.1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
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<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXE5</accession>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
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            <taxon>Diabroticites</taxon>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
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            <location evidence="1 8">Cell membrane</location>
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    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </dbReference>
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        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF131">
        <property type="entry name" value="GUSTATORY AND ODORANT RECEPTOR 63A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028127820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028127825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028127834.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50550" checksum="01E90C7EEEF74D8B" modified="2020-12-02" version="1">MFGPNINIIEDTPTTERKRSVYLEGTLPYYQNPEQNPVTKVAPFHPQGPGPGHQLPIKAFQSKSGSSSVVFDSLRPMLLFMKISGISPIAQLDMVFQVTLQWMIYSVVVFLIILGYIGYIKWDKLEMVRSAEGRFEEAVIDYLFSVYLVPIFLTPICWSEAKKLARVLTNFVVFENMYHKITKKKFQHFLGNKPVVVTIGLPILACSTMVVTHVTMVHFKLLQVIPYCYINIATYMIGGLWYMLCDLVGSMALTVADDFQEVLKNIGPANKVAEFRSLWMLLSRTVRDIGNAFSFTLTFLCLYLFLIITLTIYGLMSQIQEGLGVKDIGLAITAFFAAMMLLLISDEAHYASNCVKVQFQKKLLLVELNWMNDDAQQEINMFLRATEMNPTDMSLGGFFDVNRNLFKSLIATMVTYLVVLLQFQISIPEDGGAVNATMNRAPPQQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXU6</accession>
    <name>A0A6P7EXU6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil and C2 domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114324202</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CC2D1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127806.1">
        <property type="nucleotide sequence ID" value="XM_028272005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EXU6"/>
    <dbReference type="FunCoup" id="A0A6P7EXU6">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272005.2">
        <property type="protein sequence ID" value="XP_028127806.1"/>
        <property type="gene ID" value="LOC114324202"/>
    </dbReference>
    <dbReference type="GeneID" id="114324202"/>
    <dbReference type="KEGG" id="dvv:114324202"/>
    <dbReference type="InParanoid" id="A0A6P7EXU6"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21528">
        <property type="entry name" value="CC2D1A-B_DM14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="613"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028127806.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="88732" checksum="C6280E3BFB7FF45D" modified="2020-12-02" version="1">MFSKKEKPKRNHAGKSLSQYGLFEVPSDFDTGLGNEDDDDDDEDLEAELAALAGGGGASKPKRPPRKIIPQRELDSMVSESMKDVDDDDVSIDENDPELLSELNDIVGEDEPEEDSSPSQEAPPPASSSDIVNILVERLKNYEICEVKAKESGETTKARRYGRAIKTLKDLIKRAKSGSPIDLNDDSIPPDIHPSTAAPARPAPPVPQRPTPPEPLSPTTTDSPQEPPTEDLVSIQPEAPAYDQEKLNTLLQGQKQYKVAALKAKHEGNAQKAVLFLKVSKQFDIVIGALKSGQPVDLSDMPGPPETFSMPEPPTQESEVQQNSPAPAEEEPAAAPPALITASSTMEALQQRLGLYKEQEAKAKEENNSSKARRYGRIIKQFEQAIKANKAGKPFAYEELPTPPGYGPIPGVQQPAAEPADPAPAAPPRRPAPQPSNSGESKPSLPSPESKPARMIPKQTQADKQMVILVAKQKQFKLAALEAKKRGEMAQAKEFLRQAKGFDKLIEASIAGLPVDWSSIPVSPEAKSQLDNEYDIAMSAESDDSAGIDGDLFARLETQLQKQLKMCLTTRDHNKAIGDVAGMNRFERFALNVTKDMDVVRAARKEGRIPKFHYETKEFAIVKCCPEIEDNQMEVTVHRGLNISTDKDIDTYVKMEFPFPQETPYNDRTSTMKNTNNPDFQKTFVVPIQRNSRVCQRTFKRHSLKFELFSKGCACCGSPVTCPGCCSFLGGLPCFFGFFRSDALVGTVNLKLQPLETQCEIHDTFDLLEGRKKVGGKLEIQVKLRTPIQTQQVEQIQERWLVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2H1</accession>
    <name>A0A6P7F2H1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC114325620</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028129526.1">
        <property type="nucleotide sequence ID" value="XM_028273725.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129527.1">
        <property type="nucleotide sequence ID" value="XM_028273726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2H1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273725.2">
        <property type="protein sequence ID" value="XP_028129526.1"/>
        <property type="gene ID" value="LOC114325620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273726.2">
        <property type="protein sequence ID" value="XP_028129527.1"/>
        <property type="gene ID" value="LOC114325620"/>
    </dbReference>
    <dbReference type="GeneID" id="114325620"/>
    <dbReference type="KEGG" id="dvv:114325620"/>
    <dbReference type="CTD" id="39133"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14391">
        <property type="entry name" value="UBA_II_E2_UBCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000010">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000021">
        <property type="entry name" value="Putative ubiquitin-conjugating enzyme e2 k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042614">
        <property type="entry name" value="UBCD4_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028129526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028129527.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22523" checksum="73DB2A2588C1637C" modified="2020-12-02" version="1">MANIAAQRIKREFKEVIKSEEVAKCAIRVELLNDSYTELRGEIAGPPDTPYEGGNFVLEIRVPETYPFNPPKVRFITRIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLSAAEPDDPQDAVVARQYKENLEMFTLTAKHWTHAYAGGPCVISDCDEKIRRLIDMGIEEHKARVSLSSYNWDLEMATEQLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F548</accession>
    <name>A0A6P7F548_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114326418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114326418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130586.1">
        <property type="nucleotide sequence ID" value="XM_028274785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F548"/>
    <dbReference type="FunCoup" id="A0A6P7F548">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274785.2">
        <property type="protein sequence ID" value="XP_028130586.1"/>
        <property type="gene ID" value="LOC114326418"/>
    </dbReference>
    <dbReference type="GeneID" id="114326418"/>
    <dbReference type="KEGG" id="dvv:114326418"/>
    <dbReference type="CTD" id="43235"/>
    <dbReference type="InParanoid" id="A0A6P7F548"/>
    <dbReference type="OrthoDB" id="7323052at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028130586.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40722" checksum="6D3ABCACE11B2241" modified="2020-12-02" version="1">MDSSNMWLFNYLVPLMFLVADGVAGSQNNATDCEIQDCLRCGSKGCIKCADLMVYPSRECVSKCPFGHVQKWSTMVDYVGKICQHNGNFLGLSNNAMAVLTGVVTGSIVCIVLLTCAVLYIKFRRKTLPPLSETSSEIDDSPERKDFVKQLETLRPYAQSYLDMLNDTRRQIRELHSDGDTSAISAYRPVIRDLAKILLLLNRPVDRLAVPDDWEHLFNWADKVLKRYKRMSETSHLQVAQLVDFLQGSAITPDLTRDIDSSRGSTTMSTFKPNQVFGSSLSLQDIAINNFTSNYDSKCHLPLNPQWKFEYSLVNNLPSSEFNPATWKNSKEYLNNSIFLEDDFYQLGFRPQDEITTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FA74</accession>
    <name>A0A6P7FA74_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium-independent phospholipase A2-gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114327932</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132451.1">
        <property type="nucleotide sequence ID" value="XM_028276650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FA74"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276650.2">
        <property type="protein sequence ID" value="XP_028132451.1"/>
        <property type="gene ID" value="LOC114327932"/>
    </dbReference>
    <dbReference type="GeneID" id="114327932"/>
    <dbReference type="KEGG" id="dvv:114327932"/>
    <dbReference type="InParanoid" id="A0A6P7FA74"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07211">
        <property type="entry name" value="Pat_PNPLA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045217">
        <property type="entry name" value="PNPLA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="259"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028132451.1"/>
        </source>
    </evidence>
    <sequence length="599" mass="67931" checksum="9307CD252D593013" modified="2020-12-02" version="1">MSLTKNLSTCGKCVVNRVPHRNIVSKRKYSSGSSNIESVKMQAKNIVLNQWRLINELKKYFSKFTNDKTFETALNKEFAQFLQKIDSKTYGKGLVKYFTSQSTDIVKNTPMHETKVEKDVKQEQSIPSRLSLPIQNVLSGLSINIKSKEDEKKEIIPRWKTVTKPIVSQEAIGARTSQILVSISLADNETMKIRRIEDLISHLEQYPEAKHNAVKEGGIRSLLKIRDTTKNPQLLSSLNVAITLLGYTDPVPGVGIRILSIDGGGVRGILVIEMLRKLEELSGKPIYEMFDFICGVSTGAIIATLSGLKQKSLDEISEIYKSISTQIFNQSAFFGTSNLVWSHSYYDTPLWEKLLQEQWQDMLLIETRRNLKVPKFCAVSAVVNQSRLSAYIFRNYSLPCKVQSQYKGGYNHQVWEAVRASAAAPTYFEEFKIGNMLHQDGGILVNNPTAVAIHEAKLLWPNTPIQCVLSFGTGRTVPNPVLSCYQDKDATITNSSWKKKFFAIIDSATDTEGVHTMLSDLLPTNVYYRFNPYLTEMLDIAEIDPNKLEQLKRDALMYLRRNEDKFHDAAKALNQKKSVTQKTMDWLSLRKEMHGINMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAV8</accession>
    <name>A0A6P7FAV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Presequence protease, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114328377</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133014.1">
        <property type="nucleotide sequence ID" value="XM_028277213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAV8"/>
    <dbReference type="FunCoup" id="A0A6P7FAV8">
        <property type="interactions" value="1705"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277213.2">
        <property type="protein sequence ID" value="XP_028133014.1"/>
        <property type="gene ID" value="LOC114328377"/>
    </dbReference>
    <dbReference type="GeneID" id="114328377"/>
    <dbReference type="KEGG" id="dvv:114328377"/>
    <dbReference type="InParanoid" id="A0A6P7FAV8"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="12">
        <location>
            <begin position="506"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028133014.1"/>
        </source>
    </evidence>
    <sequence length="1026" mass="116906" checksum="143919039DF668E6" modified="2020-12-02" version="1">MWSSKISRTSFTTLDIYRRITRGVTNLAKSRQASTSDIHLFKVGEKYHGFEAKRIASIPELKTTALYLLHEKTKAQYLHLYRNDSNNVFSVNLRTTPMNSTGLPHILEHTVLCGSEIFPVRDPFFKMLNRSLATFMNAMTGPDYTMYPFSTLNYTDYLNLQKVYLDAVFRPQLKELDFMQEGWRLENVDPNDVNSDIIIKGIVYNEMKGVFASNDSILGQKLQNLILPSHTYGVISGGDPQEIPNLTWNDLKNFHKQHYHPSNSRLFSYGNFPLLPSLEYIDKEYLSKYAYSPPTHTVVPKEKRWEAAKREHIKCRYDVLGAPFEKQNTISISVLASDTTDAYQTLVVDFLTNLLIKGPNAPFYQSMIEPNISGGFTASTGFDNQPRDGMVTIGLQSVKKEDFDKVISIFEQTVDKVIEKGFEPHHIEMVLHSYELSLAHESSNYGLGLLFGISTAWNHTENIIEHLQSRKWIDRLKQDIKTNPNFLQDNVRKIFKDNQHKLILTMSADKDFEAELAKAENQLIKQKTKGLSSKDKKVIHEKALELQKQQMEPTRTELLPTLLIDDISSDVEKVDMEKVSLNNVPTQINKVNSNGIVYFKAMLNTNYLSPDQQMLLPLFCFTISKLGTDKLNYKEFDSLINRKTGGLTLNSHIGESLYSLHTYQPSLLLSSYALERNVESMWDIWNQLFTMRGLKDVDRFKMLVELYMSNLSNGITESGHVYAMQAASSLVSGTAYQVELLSGLQHISYMKSLVSTSNYKAILKEILNIAEILFDKKKMRVALNLTPDNQTDIIRTYENFIGTLPQATVPHLQSEDTYIVGDVWSPTEAVNCQHHVLNLPVNYCSKAVLTVPFTHADYAKLKILSRLLSSKYLHPELREKQGAYGGGARVLSDGVFTFFSYRDPRNLDTLDVFDNTYNWLRSEIDKITPQDIFEAKLGVFQSVDTPIPPSSKGNEEFLKGLTTDIKQRYRAELLSVGKNDLTEVAEKYLGPANMLQTGKVVLGPKTEQMDVSKRKDEMWTVVESNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBZ2</accession>
    <name>A0A6P7FBZ2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dopamine receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114326710</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130930.1">
        <property type="nucleotide sequence ID" value="XM_028275129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBZ2"/>
    <dbReference type="FunCoup" id="A0A6P7FBZ2">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275129.2">
        <property type="protein sequence ID" value="XP_028130930.1"/>
        <property type="gene ID" value="LOC114326710"/>
    </dbReference>
    <dbReference type="GeneID" id="114326710"/>
    <dbReference type="KEGG" id="dvv:114326710"/>
    <dbReference type="InParanoid" id="A0A6P7FBZ2"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15067">
        <property type="entry name" value="7tmA_Dop1R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000282">
        <property type="entry name" value="Dopamine receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF185">
        <property type="entry name" value="DOPAMINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="61"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028130930.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44047" checksum="F5FE34CCF8484E72" modified="2020-12-02" version="1">MNNSDYYPWVFQNASYYNLENWTGNYSQEYLDAWEKWTELIQDRAVVVSLLLLFSMCTVFGNMLVILAVIRERYLHTPTNYFITSLAVADCLVGLVVMPFSALYEVLGHTWFFGADWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPITYPMRMTKLRSMLLIAAVWVCSSAISFPAIGWWRAVRNAPIPAFTCPFTEHLGYLIFSSTISFYLPLFVMLFTYFRIYRAAAAQTKSLRLGTKQILLGSGELELTLRIHRGGTCKAPESRLYSTQEDEPLTALQNNGLSRVASTRLNPHSKNFSLSRKLAKFAKEKKAAKTLGIVMGVFVVCWLPFFVVNLLSGFCLQCISHERIVLAVVTWLGWINSSMNPVIYACWSRDFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCF1</accession>
    <name>A0A6P7FCF1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114326869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114326869</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131123.1">
        <property type="nucleotide sequence ID" value="XM_028275322.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504808.1">
        <property type="nucleotide sequence ID" value="XM_050648851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCF1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275322.2">
        <property type="protein sequence ID" value="XP_028131123.1"/>
        <property type="gene ID" value="LOC114326869"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648851.1">
        <property type="protein sequence ID" value="XP_050504808.1"/>
        <property type="gene ID" value="LOC114326869"/>
    </dbReference>
    <dbReference type="GeneID" id="114326869"/>
    <dbReference type="KEGG" id="dvv:114326869"/>
    <dbReference type="InParanoid" id="A0A6P7FCF1"/>
    <dbReference type="OrthoDB" id="6375980at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028131123.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23245" checksum="130B198830920D50" modified="2020-12-02" version="1">MGDNFVETVIELHRSKSWKEILNLNTHSDNQNALKLLWVWPEIKNIRYIKNLVKDLGYKGIISLGCGCGLLEWIISEATGLPVLGYEINPEWWESKYSNYKFINLHYVDSISEKTLDSNYALLFCYFNDREAFQKYVENYRGNLIFIIGPGDETCRHTDPEPFSADFGSSEWKLYCFQEVKSSGDYIAAYVREERSLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFE1</accession>
    <name>A0A6P7FFE1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329747</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329747</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134744.1">
        <property type="nucleotide sequence ID" value="XM_028278943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFE1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278943.2">
        <property type="protein sequence ID" value="XP_028134744.1"/>
        <property type="gene ID" value="LOC114329747"/>
    </dbReference>
    <dbReference type="GeneID" id="114329747"/>
    <dbReference type="KEGG" id="dvv:114329747"/>
    <dbReference type="InParanoid" id="A0A6P7FFE1"/>
    <dbReference type="OrthoDB" id="6661750at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028134744.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21839" checksum="5F61AA522E9111FF" modified="2020-12-02" version="1">MMLVITAIIGIICFQLHTIFSAKILYEMETLEICKDPKYAHIDNMVKKLQISRYNRTVKMLEFHISSKDPLDENIEGTISAAKWTNGKWLSIPFIPYVPDICKYAYQNYPEQVRFLMEGFKVEHPDRCPFPAGNHTLHNYPMVTKFEVNSLVPITGRFMFRVILRKIATKEIVYCIQGTTLQTAQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG92</accession>
    <name>A0A6P7FG92_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atypical kinase COQ8B, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114329118</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133937.1">
        <property type="nucleotide sequence ID" value="XM_028278136.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515522.1">
        <property type="nucleotide sequence ID" value="XM_050659565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515523.1">
        <property type="nucleotide sequence ID" value="XM_050659566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG92"/>
    <dbReference type="FunCoup" id="A0A6P7FG92">
        <property type="interactions" value="1004"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659565.1">
        <property type="protein sequence ID" value="XP_050515522.1"/>
        <property type="gene ID" value="LOC114329118"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659566.1">
        <property type="protein sequence ID" value="XP_050515523.1"/>
        <property type="gene ID" value="LOC114329118"/>
    </dbReference>
    <dbReference type="GeneID" id="114329118"/>
    <dbReference type="KEGG" id="dvv:114329118"/>
    <dbReference type="CTD" id="32239"/>
    <dbReference type="InParanoid" id="A0A6P7FG92"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="7">
        <location>
            <begin position="295"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028133937.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="73842" checksum="3437857F93919C53" modified="2020-12-02" version="1">MSRAQDLACLLKSLQLIAEACVKLQAEKAKFIWSNSSLRHAAESCSTACQKAPQFGGTNPPDLKDSIDRVSTVLHGLRVYTNVALGQKDTVTAISAEILKDTSNVLNKEDYKRPPQLKPEVLDSNKKVYTIELTEDDKKLLKRLDMEHRAKLIKEKDREENKDLSTREKEVKAKPVKEKEAAKITAVPNVKSKMKLSDSAKQRKVPSSRIGRMVSFGTLAAGLGIGTATEYAKRTLGIGDPPGNASTLFMSKANMDRVVDTLCKVRGAALKLGQILSIQDDSIINPELAQALERVRKSADFMPDWQLEEVMVAELGPHWRNKFGDFENVPFAAASIGQVHQAKTKDGREVAIKIQYPGVAKGIESDIDNLGGIMKMWNVFPKGMFLENLMVVAKRELAWEVNYIREAVCTKRFKKVLEPYTEYYVPDVIDELSTKQIFTTELLDGVPVDQCFDLDLEHREFIGQKVLELCLLEILKFRYMQTDPNWANFLYNPSKKQILLLDFGASREYPKAFMDQYVKILKAACDGDRDTVLNVSRDLGFLTGYESKIMEDAHVDAVMILGEIFRTNDKYDFGNQDMTMRIQDLAQTMLVHRLCPPPEEIYSLHRKLSGVFLLCSKLKVKLACRGMFLSLYNDYMAEGNTDADNNVIDKSYNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHK4</accession>
    <name>A0A6P7FHK4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC114328120 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114328120</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132695.1">
        <property type="nucleotide sequence ID" value="XM_028276894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHK4"/>
    <dbReference type="FunCoup" id="A0A6P7FHK4">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276894.2">
        <property type="protein sequence ID" value="XP_028132695.1"/>
        <property type="gene ID" value="LOC114328120"/>
    </dbReference>
    <dbReference type="GeneID" id="114328120"/>
    <dbReference type="KEGG" id="dvv:114328120"/>
    <dbReference type="InParanoid" id="A0A6P7FHK4"/>
    <dbReference type="OrthoDB" id="10037294at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011106">
        <property type="entry name" value="MANSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876:SF1">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07502">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00765">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028237602" evidence="10">
        <location>
            <begin position="21"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="11">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="MANSC" evidence="12">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028132695.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="67544" checksum="055E3BBEAA3381B4" modified="2020-12-02" version="1">MFSDLVKYLVLFTFLLFVASDNIVRVKRNDIDLPMCIEKFNVHRDKIIRTQDSQNMGAKYLNELDLGSREECLHLCCETENCDVFVFEEKNSGSCYLFQCGPPEDFKCKFTHHVNYSSAILSINRHLPDLESQIKLTKHEQDLNKLRKSDMEPEAPAHLVPDVRTTPSTTTTTISPIREIIPITKNSKVTAEDPKCTRFQFECRSTRECIAIYNACDGIPQCADGSDEGPELGCPESSITTATALPVVHVNNVPIQPLLQVRYDANIQQPQLPIPQQNMYLQQPQLPRDQPPILTPSIQRNSPETADYMHSSGSMNVNPRLQYESPLQPYVPQLPAMQGQPNWIGHQSNQMPPQIPQYADKASRIFNHKESGFQVPDGQEIRYNKYKGAMQYLHRALGYSSASLNTAGSGSAAYPKGGNYYPENTYRQPIQQENWPSDDGIYEQRSAQENIQNRDQKIDYKANLGRQQISNTVRNDEGTNPKHVQEQLAHDLKHSKENMEHAKIDNSKVKITKHSHHEEEQYPDVVAYKLSGADDLEDGMAHTQKGAVLSVSLGLIITFIMAVLIGCRLKVVRRRIRKNGKSYAHDADFLVNGMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJA8</accession>
    <name>A0A6P7FJA8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114328448</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133103.1">
        <property type="nucleotide sequence ID" value="XM_028277302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJA8"/>
    <dbReference type="FunCoup" id="A0A6P7FJA8">
        <property type="interactions" value="1379"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277302.2">
        <property type="protein sequence ID" value="XP_028133103.1"/>
        <property type="gene ID" value="LOC114328448"/>
    </dbReference>
    <dbReference type="GeneID" id="114328448"/>
    <dbReference type="KEGG" id="dvv:114328448"/>
    <dbReference type="CTD" id="44207"/>
    <dbReference type="InParanoid" id="A0A6P7FJA8"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028133103.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="23734" checksum="F963B2D81FB87853" modified="2020-12-02" version="1">MSLGVRKIFSVGSKLVRPSVQIVGQRCCSSGSKDGYFYVNDKEPSMEFGAITDRAAQTMFFTELFRGFGVTLAHIFKEPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWESEIASNIHADHLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKS4</accession>
    <name>A0A6P7FKS4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114331297</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028136621.1">
        <property type="nucleotide sequence ID" value="XM_028280820.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519199.1">
        <property type="nucleotide sequence ID" value="XM_050663242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKS4"/>
    <dbReference type="FunCoup" id="A0A6P7FKS4">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280820.2">
        <property type="protein sequence ID" value="XP_028136621.1"/>
        <property type="gene ID" value="LOC114331297"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663242.1">
        <property type="protein sequence ID" value="XP_050519199.1"/>
        <property type="gene ID" value="LOC114331297"/>
    </dbReference>
    <dbReference type="GeneID" id="114331297"/>
    <dbReference type="KEGG" id="dvv:114331297"/>
    <dbReference type="InParanoid" id="A0A6P7FKS4"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000028">
        <property type="entry name" value="Dual specificity phosphatase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF528">
        <property type="entry name" value="PUCKERED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="91"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="233"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028136621.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44907" checksum="ED7319654E42D2C2" modified="2020-12-02" version="1">MSVCLESSQPRDGLKLPLNRSFSEPGSQTSPSHLPLGCPNPKRFKLDTSSVSLPTSPCAESAHLQRTWVLNNVKYMDDDALKSKMEDRRPGPKSYILLDCRPFISYNMNHIAGAINVNCSDRFNRRRLQQGKATLADLATTREGKEVLKKRLFREVIIYDDSTSDKERITVGHPLLLVLTSLVDDHKEPALLIGGHREFHRKYKELCEDTLMSALSNRSSPSSPATLADVDSFPASKVLPFLYLGNLKDATDPSCLRGLGTTCVLNVTSQLPGYHEEYGITYKQIPATDSEHQNLKQYFEEAFEFIEAARKSGSRVLVHCQAGISRSATIAIAYIMKYKQMSMVEAYKKVKEARPIISPNLNFMGQLLELEQSLRNDTSSSSHQCRWTQQNTDEVTPGCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FM80</accession>
    <name>A0A6P7FM80_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114331864</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114331864</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137349.1">
        <property type="nucleotide sequence ID" value="XM_028281548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FM80"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281548.1">
        <property type="protein sequence ID" value="XP_028137349.1"/>
        <property type="gene ID" value="LOC114331864"/>
    </dbReference>
    <dbReference type="GeneID" id="114331864"/>
    <dbReference type="KEGG" id="dvv:114331864"/>
    <dbReference type="InParanoid" id="A0A6P7FM80"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027784964" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028137349.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18875" checksum="3403E6B9D38C7142" modified="2020-12-02" version="1">MAIKTLFLVVILAANVIDFSKGNKDTQLSGVIDIVDNILPTRNPCNCQKELDRIYDTLCEVYEDVTELSCEIDDIKKYMDKLEQRTCRQNSTLTSLKVEIDKVKKNQTNTVNLLKVQTTVLQKIIVNLKKIEDEDTKIHKQVDKQTGSIHYLYQLVLNTVICLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPD3</accession>
    <name>A0A6P7FPD3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114332461</name>
        <name evidence="10" type="synonym">LSM4</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138056.1">
        <property type="nucleotide sequence ID" value="XM_028282255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPD3"/>
    <dbReference type="FunCoup" id="A0A6P7FPD3">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282255.2">
        <property type="protein sequence ID" value="XP_028138056.1"/>
        <property type="gene ID" value="LOC114332461"/>
    </dbReference>
    <dbReference type="GeneID" id="114332461"/>
    <dbReference type="KEGG" id="dvv:114332461"/>
    <dbReference type="InParanoid" id="A0A6P7FPD3"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028138056.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15367" checksum="1BB07961A4A19680" modified="2020-12-02" version="1">MLPLSLLRTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEVIDMVKEEAVVKNKGRNDMKGGRGGQNQRNRPASRGNFGGARGNKQGGQGGRNPQLQKQKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPM2</accession>
    <name>A0A6P7FPM2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329890</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134953.1">
        <property type="nucleotide sequence ID" value="XM_028279152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPM2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279152.2">
        <property type="protein sequence ID" value="XP_028134953.1"/>
        <property type="gene ID" value="LOC114329890"/>
    </dbReference>
    <dbReference type="GeneID" id="114329890"/>
    <dbReference type="KEGG" id="dvv:114329890"/>
    <dbReference type="InParanoid" id="A0A6P7FPM2"/>
    <dbReference type="OrthoDB" id="6781046at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028402357" evidence="1">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028134953.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36100" checksum="351AEC4BDC398F9C" modified="2020-12-02" version="1">MKLISLFSICALVFLVQNVNSKPDYFTAFVIRIGINTALASLRRLSSITLLRKISLSTPSIISPVITDTFEIKNVSIYGFSTLKYNTRVFVDNEVENNVTVRTINVNLNTSLAEFGINAEYLKDIKVFTLFHVYGEGDFRFGIDNIVLKLNVTLNNRGSLHIQDLKIKLSFGGSNGTHITGFQKNKTLSKYLTAIIKNLQRNFYFWYYRNKICTECFLSESLKFGTNILLRQKAVKYNRCRCLKENGSEIIRKLENIIEMLQDGKLSKKFPLTPQLKNQLIQMVKNVLKQNNITAMYFDNVQNLLNLFSINSIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQU2</accession>
    <name>A0A6P7FQU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114330152</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135270.1">
        <property type="nucleotide sequence ID" value="XM_028279469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQU2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050643725.1">
        <property type="protein sequence ID" value="XP_050499682.1"/>
        <property type="gene ID" value="LOC126880067"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FQU2"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06860">
        <property type="entry name" value="PX_SNX7_30_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="71"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028135270.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="53091" checksum="74ACF9A6969CC223" modified="2020-12-02" version="1">MASSASAVLDVVVENKEISTGAAKDKEVDPSSVCSGDSTFDNSLVQSPSIESFSTIHDIENLAELNMDENSDLCVKIDNPQKHLETLETYITFRITTKVARIEFSDNEYVVHRRYNDFLWLRQKLVECHPFCIVPPLPGKHSLIGQLDRYSKEFILLRMKALNVFITRVAKHPILSCNEHFKVFLTAHSLGFTLHRRQRHPVQQKIRTFNHGNSSHSVLKNKHMEFDKTKTYLTTLSEKLSSIEKISSRINKERCEYVSELNSYHPIFTTWATSEPELSEMLQNIGSAMERSSAAQNALVQSYSNTVGNPIKDFLSYIEIAQETLRKRESYQYAYEVSVEDLNKRHSEKDKLVAISQNPSQSAAGFSLWKQSSCDDKLEKLGSYIPQLIKKVESNQDNLECANESLRSDLQRWHSEKQQCLKKILLDFVNKQINYYQATVNSWEYVTSEINKQNQSLRNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTV9</accession>
    <name>A0A6P7FTV9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Akirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114330935</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136185.1">
        <property type="nucleotide sequence ID" value="XM_028280384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTV9"/>
    <dbReference type="FunCoup" id="A0A6P7FTV9">
        <property type="interactions" value="1846"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660986.1">
        <property type="protein sequence ID" value="XP_050516943.1"/>
        <property type="gene ID" value="LOC126891721"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FTV9"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22240">
        <property type="entry name" value="akirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028136185.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19927" checksum="82C52B17B290A9F6" modified="2020-12-02" version="1">MACATLKRSLDWEPVLGGRPAKRRRCVPFCSSPTQSGIGSPGPSSSPTGSSSPKSSVFPDVLSKTLTPENLIDNLKTEIKRLQKRKQLQYNCMETSDGSSSGGESSESPSRSEKPLFTFRQVGMICERMLREREVEIREEYDNVLTAKLSEQYDAFVKFTYDQIHRNYTNTAVPSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVF6</accession>
    <name>A0A6P7FVF6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-phase entry cyclin-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334481</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140326.1">
        <property type="nucleotide sequence ID" value="XM_028284525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVF6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284525.2">
        <property type="protein sequence ID" value="XP_028140326.1"/>
        <property type="gene ID" value="LOC114334481"/>
    </dbReference>
    <dbReference type="GeneID" id="114334481"/>
    <dbReference type="KEGG" id="dvv:114334481"/>
    <dbReference type="InParanoid" id="A0A6P7FVF6"/>
    <dbReference type="OrthoDB" id="6370339at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140326.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="49409" checksum="16AD23D84A52F677" modified="2020-12-02" version="1">MLNSLKGNISRTMLKNKCKKEIENILQEGNNTVYVAEDVKTDPDRVVPIYNDQDCGKPQKNKKSDRIALAPVPESDWENKENFRINKKSNTNEAGPSSKNQRTNLKTLTLNENFEGLPKIDVSPIIPNPFSKYSIKKTSSDARIAKLIKRQRPARLTDYLDQPFQDIWRDHFQTSLDREQEVLPGDFLTRFGVSNMDRAKCINILLKIQVFYHLHEEIVYCSVNMFDRILFSIEIPQSVYEIVAVTCLWLASKMSGQIMTPSNILMMCSETYISKQMIHMERKILKILDFRIPHIEPVFFVEYFFLELHITPCSKLYASTYFILDFSTFFEEFSNFFPSEIAAGSILIAVKLFHKDEQQEVLNYLKKTIPRGTLARSHQFQLKLLQFMFTVDENVVSKVLLAKYKNCVWLLPVERSTENIPMVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXY8</accession>
    <name>A0A6P7FXY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC114335404</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13 14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028141438.1">
        <property type="nucleotide sequence ID" value="XM_028285637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141439.1">
        <property type="nucleotide sequence ID" value="XM_028285638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXY8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642442.1">
        <property type="protein sequence ID" value="XP_050498399.1"/>
        <property type="gene ID" value="LOC126879429"/>
    </dbReference>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF113">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028141438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028141439.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31918" checksum="F4A3E5686BB66900" modified="2020-12-02" version="1">MAAVVNLYNYFYNLADPRVKNWFMMENPFPTLGIIGVYLLLVLQILPNFMKNRKPFELTKIIRLYNIFQVVACIGIMYSILTSGWIQGEYNIGCSPIDYSNKPNPVKLLGAFYWLYLLKGVELIETIFFALRKKNNQITGLHIYHHGSTFFLAWIGCKFIGGGMASIPPFVNSFIHVLMYTYYYLSSLGPEWQKKLQPWKPRLTMLQMIQFTLLIIHSLTALQTDCKVPKQFLLIYIPNVVVIFKMFYDFYTTSYTPSKKQQINGLHSKVKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYR6</accession>
    <name>A0A6P7FYR6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thioredoxin domain-containing protein 5 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114332372</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137963.1">
        <property type="nucleotide sequence ID" value="XM_028282162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYR6"/>
    <dbReference type="FunCoup" id="A0A6P7FYR6">
        <property type="interactions" value="1028"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282162.2">
        <property type="protein sequence ID" value="XP_028137963.1"/>
        <property type="gene ID" value="LOC114332372"/>
    </dbReference>
    <dbReference type="GeneID" id="114332372"/>
    <dbReference type="KEGG" id="dvv:114332372"/>
    <dbReference type="CTD" id="32124"/>
    <dbReference type="InParanoid" id="A0A6P7FYR6"/>
    <dbReference type="OrthoDB" id="71336at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000398">
        <property type="entry name" value="Thioredoxin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028280072" evidence="6">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="264"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028137963.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43718" checksum="B8546134AC10E36F" modified="2020-12-02" version="1">MGPHSVLSLMFASVVITLAHEDVYSIKYTTENFSQEVGKKNHFVMFYAPWCGHCQKFSPKWEQLAEMLNEDDTNNIKIAKVDCTTDSEVCSEQDITGYPTLKFYKVGDSEGVRFRGTRDLPSITNFIKEQLREGDESHTEEAVSDEATAVDGLTELTEDNFHKHVKSGKHFIKFYAPWCGHCQKLAPAWEQLAKTLELDNEVTVGKVDCTQHRSVCNDFDVKGYPTLLWIENGAKVDKYQGDRSHVDLKQYVNKMLGSEKTEGATPKEAASDADLPSGEVTGDNFKSTIESGISFVKFYAPWCGHCKRLAPVWDSLREKLVSRPEVKVLKVDCTLEVNKQLCNDEEIEGFPSLNLYQNGEKIASYSGSRSLEDLQDFLLKHTPRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2S9</accession>
    <name>A0A6P7G2S9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cleavage and polyadenylation specificity factor 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114337072</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143259.1">
        <property type="nucleotide sequence ID" value="XM_028287458.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506835.1">
        <property type="nucleotide sequence ID" value="XM_050650878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2S9"/>
    <dbReference type="FunCoup" id="A0A6P7G2S9">
        <property type="interactions" value="1600"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650878.1">
        <property type="protein sequence ID" value="XP_050506835.1"/>
        <property type="gene ID" value="LOC114337072"/>
    </dbReference>
    <dbReference type="GeneID" id="114337072"/>
    <dbReference type="KEGG" id="dvv:114337072"/>
    <dbReference type="CTD" id="42240"/>
    <dbReference type="InParanoid" id="A0A6P7G2S9"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="31"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="253"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="484"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028143259.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="77977" checksum="75DE19A9E5D86675" modified="2020-12-02" version="1">MSYKRKPDSQVPAEESDLLTIRPLGAGQEVGRSCIMIEFKGKKIMLDCGIHPGLSGMDALPFVDLIEADEIDLLLISHFHLDHSGALPWFLLKTSFKGRCFMTHATKAIYRWLLSDYIKVSNIATEQMLYTEADLEASMDKIETINFHEEKDILGVKFWAYNAGHVLGAAMFMIEIAGVKILYTGDFSRQEDRHLMAAEIPTIHPDVLITESTYGTHIHEKREDRETRFTTLVHDIVNRGGRCLIPVFALGRAQELLLILDEYWSQHPELHDIPIYYASSLAKKCMAVYQTYINAMNDRIKRQIAINNPFVFKHISNLKGIDHFEDIGPCVIMASPGMMQSGLSRELFENWCTDSKNGVIIAGYCVEGTLAKTILSEPEEITTMLGQKLPLKMSVDYISFSAHTDYQQTSEFIRMLKPPHVVLVHGEQNEMNRLKAALQREYEDDPNTTINLYNPRNTHSVELYFRGEKTAKVMGQLAVDEPQPGKTLNGILVKRNFNYHILSAEDLPQYTDLSMSQIMQRQSLHFACNVAMLRHMLTQVAGLLEPIDGDKKLKAFNAIDITIEQKVVTLEWMANPVNDMYADSLVAAILQADLLDVPLKSMNTSIKVDRMHFKECLIEMLQDMFGEDSVPKIFKGEKLYVTVNDKRADINLTNLEVKCPNDETFQQIVQTAVTKLYQCLAPPQVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8R4</accession>
    <name>A0A6P7G8R4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mapk-regulated corepressor-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114335233</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCRIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141233.1">
        <property type="nucleotide sequence ID" value="XM_028285432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8R4"/>
    <dbReference type="FunCoup" id="A0A6P7G8R4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285432.1">
        <property type="protein sequence ID" value="XP_028141233.1"/>
        <property type="gene ID" value="LOC114335233"/>
    </dbReference>
    <dbReference type="GeneID" id="114335233"/>
    <dbReference type="KEGG" id="dvv:114335233"/>
    <dbReference type="InParanoid" id="A0A6P7G8R4"/>
    <dbReference type="OrthoDB" id="9983138at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029428">
        <property type="entry name" value="MCRIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14799">
        <property type="entry name" value="FAM195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028141233.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="16248" checksum="31184DFC6B5B2252" modified="2020-12-02" version="1">MYNVKGPSKFVAKTTRRGIPQTIDNLREFNKRVPESEENDYTNGPKPVFHKKSATSSPKHKNLTPQHEEIINFIHESWNSVCAEFDQENSELNEGESSTICYYEEEPCLSLENFRPFDLESWWGKRLFAYVTNPETQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G987</accession>
    <name>A0A6P7G987_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114337223 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114337223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143432.1">
        <property type="nucleotide sequence ID" value="XM_028287631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G987"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287631.2">
        <property type="protein sequence ID" value="XP_028143432.1"/>
        <property type="gene ID" value="LOC114337223"/>
    </dbReference>
    <dbReference type="GeneID" id="114337223"/>
    <dbReference type="KEGG" id="dvv:114337223"/>
    <dbReference type="InParanoid" id="A0A6P7G987"/>
    <dbReference type="OrthoDB" id="6755725at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34415:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028143432.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="34155" checksum="1CFFA043527BAAF9" modified="2020-12-02" version="1">MQIVNCEAVAMDFEKKLSTPNIPTNDVYYKRQLTLHSFNIHALSTGNTTFYCFPETIGGKGSNEVVSFLHHFIFVQLDLSVRHLHIFCDSCDGQNKNFTVFRYLHYVVNTAKRLDSIKVTFPIRGHSYVECDRDMSVINQKIMAELPEDWYTEIRSCRVKPNPFDVVEVDQSLIRNWLLFLDQIYVTKPTYKSRPIGELEILKDHPRLLKHRDSYNGQWETSIIRKPFTNSDEVQLPERQFILPVKLYTELKKISKEKFNHLVHLSQFCTSERATINSESRCSRNKQTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAJ7</accession>
    <name>A0A6P7GAJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114339833</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028146321.1">
        <property type="nucleotide sequence ID" value="XM_028290520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAJ7"/>
    <dbReference type="FunCoup" id="A0A6P7GAJ7">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290520.2">
        <property type="protein sequence ID" value="XP_028146321.1"/>
        <property type="gene ID" value="LOC114339833"/>
    </dbReference>
    <dbReference type="GeneID" id="114339833"/>
    <dbReference type="KEGG" id="dvv:114339833"/>
    <dbReference type="InParanoid" id="A0A6P7GAJ7"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028189699" description="thioredoxin-dependent peroxiredoxin" evidence="9">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028146321.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27118" checksum="29D11BE1A1884D4F" modified="2020-12-02" version="1">MTSFKLIIFSISTVLAITNVVADESCQTFAGGSVYPASEKQAVHNLQYSKAVISKPAPYWEATAVKNGEIVQLKSTDFLGKYLVFFFYPLDFTFVCPTEILAFSDRIKEFRKINTEIVACSVDSHFTHLAWINTPRKEGGLGNVNFPILSDLTHNIAKDYGVYLDDLGHTLRGLFIIDTKGVVRQITMNDLPVGRSVDETIRLVQAFQFTDQNGEVCPAGWKPGQDTIIPNPVEKKKYFEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAN9</accession>
    <name>A0A6P7GAN9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114335814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335814</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028141903.1">
        <property type="nucleotide sequence ID" value="XM_028286102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAN9"/>
    <dbReference type="FunCoup" id="A0A6P7GAN9">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286102.1">
        <property type="protein sequence ID" value="XP_028141903.1"/>
        <property type="gene ID" value="LOC114335814"/>
    </dbReference>
    <dbReference type="GeneID" id="114335814"/>
    <dbReference type="KEGG" id="dvv:114335814"/>
    <dbReference type="InParanoid" id="A0A6P7GAN9"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141903.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23061" checksum="B9F8083E8EA18C2B" modified="2020-12-02" version="1">MLEPFLSQLNEMRIVLASGSKQRAALLTSTKLKYEIVPSDYEENLDPKEHTFSEFVEKTAIGKLLDVWEKLKNDTRKPDIIIGVDTMVTYNGRMYGKPKSRDDAIKTITDLTQSGIPNSVYTGVAIRYKGNIHRFTEVTTVYMLKLDLEEIVAYVDTGEPMGKAGGYGIQGIASTFVKRIEGDCNNVIGLPLCRLACELKKMITNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GB47</accession>
    <name>A0A6P7GB47_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC114335954</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114335954</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142053.1">
        <property type="nucleotide sequence ID" value="XM_028286252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GB47"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656567.1">
        <property type="protein sequence ID" value="XP_050512524.1"/>
        <property type="gene ID" value="LOC126888370"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GB47"/>
    <dbReference type="OrthoDB" id="7683421at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028142053.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12684" checksum="F278DC84A9390299" modified="2020-12-02" version="1">MTDSVRYCSVCRTNSRDYNRLSFFRFPKDEKRFAEWRKILQCEKIAMHSAQYCYERYKVCALHFEDKAFAGFGKCRLKKDAKPSIHLVSNIKVECTEEPFEPDPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGB2</accession>
    <name>A0A6P7GGB2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114337768</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144103.1">
        <property type="nucleotide sequence ID" value="XM_028288302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGB2"/>
    <dbReference type="FunCoup" id="A0A6P7GGB2">
        <property type="interactions" value="1095"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288302.2">
        <property type="protein sequence ID" value="XP_028144103.1"/>
        <property type="gene ID" value="LOC114337768"/>
    </dbReference>
    <dbReference type="GeneID" id="114337768"/>
    <dbReference type="KEGG" id="dvv:114337768"/>
    <dbReference type="CTD" id="58533"/>
    <dbReference type="InParanoid" id="A0A6P7GGB2"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07621">
        <property type="entry name" value="BAR_SNX5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06892">
        <property type="entry name" value="PX_SNX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000008">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014637">
        <property type="entry name" value="SNX5/SNX6/SNX32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036924">
        <property type="entry name" value="Snx5_Snx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028144103.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46962" checksum="C17740C0D44EF1AC" modified="2020-12-02" version="1">MRFQKSDRSPDEGNNVPLTDSSLIVDISDALSEKDKVKFTVHTRTSMKNFQKQEFLVVRQHEEFIWLHDRYEEEPKYAGYIIPPPPPRPNFDASREKLQRLGEGEGTMTKEEFTKMKQELEAEYLATFKKTVAMHEVFLTRLASHSIFREDQHLHVFLEYDQDLCARPKGKLQQLGGLIKSVGTTTDQYYLNATVRDVNDFFEQQMNSLTEYHNQLKDATYRTDKMTEKHKELADSYIKISGGLIQLANSDNGRLDKYLSRVSDTFEKVRKLESRVASDQDLKLADTLRYYMRDSQAARALLVRRLRCLANYENANKTLEKARHKNKEIHAAPEIQEAEKAQSVACEQFESISAQAKEELLDFKTRRLHAFRKSLIELAELEIKHARSQHDLLKKSIANLNELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGB6</accession>
    <name>A0A6P7GGB6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114342182</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114342182</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148774.1">
        <property type="nucleotide sequence ID" value="XM_028292973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGB6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647978.1">
        <property type="protein sequence ID" value="XP_050503935.1"/>
        <property type="gene ID" value="LOC126882902"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GGB6"/>
    <dbReference type="OrthoDB" id="10551745at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028148774.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13396" checksum="016A06C7E0C0AE54" modified="2020-12-02" version="1">MAPRKPPVGRPSRGASGVNKIKNDRPFSPGQIAKNRFYNFLKDMKKTVPGVNLNKLETESVRLRNKLGAKSKTPYSTIARRSRRKKIRIGRRRRSRNRSRSRKRSKSHRRSTIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKR1</accession>
    <name>A0A6P7GKR1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Fez family zinc finger protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114339369</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145808.1">
        <property type="nucleotide sequence ID" value="XM_028290007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKR1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663380.1">
        <property type="protein sequence ID" value="XP_050519337.1"/>
        <property type="gene ID" value="LOC126893328"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GKR1"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000103">
        <property type="entry name" value="FEZ family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000251">
        <property type="entry name" value="FEZ family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000227">
        <property type="entry name" value="fez family zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000164">
        <property type="entry name" value="Fez family zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000194">
        <property type="entry name" value="Fez family zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000863">
        <property type="entry name" value="fez family zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF409">
        <property type="entry name" value="ZINC FINGER PROTEIN 275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028145808.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41295" checksum="1E88721C0DCD1405" modified="2020-12-02" version="1">MAEISTNICLPQQKPPSSPARTLNFSIAKIMEPDTKLRKSDPERGKDNILNLPQSSAFESAFKKYVPNVLRSPDFLQNYPLVYYHPSQLMLGSVSVYSSSVVPEPSEQTGSSPSVNPLSLHFNQVKTSPVAVQSKTTSSSNVSSPVLTPKQKSFECGECGKVFNAHYNLTRHMPVHTGARPFVCKICGKGFRQASTLCRHKIIHTSEKPHKCHTCGKAFNRSSTLNTHARIHAGYKPFICEFCGKGFHQKGNYKNHKLTHSGEKAYKCSVCSKAFHQIYNLTFHMHTHNDKKPFTCRVCGKGFCRNFDLKKHMRKLHENSGNCIESDCISSTSQGPTNTSYSADRNIHHFISPFIRPPMTVPVYSSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLE7</accession>
    <name>A0A6P7GLE7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoribonuclease MBLAC1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114338206</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68096"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:68097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144595.1">
        <property type="nucleotide sequence ID" value="XM_028288794.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514964.1">
        <property type="nucleotide sequence ID" value="XM_050659007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GLE7"/>
    <dbReference type="FunCoup" id="A0A6P7GLE7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659007.1">
        <property type="protein sequence ID" value="XP_050514964.1"/>
        <property type="gene ID" value="LOC114338206"/>
    </dbReference>
    <dbReference type="GeneID" id="114338206"/>
    <dbReference type="KEGG" id="dvv:114338206"/>
    <dbReference type="InParanoid" id="A0A6P7GLE7"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07711">
        <property type="entry name" value="MBLAC1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028144595.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22591" checksum="5D3F28E41CDC6BF4" modified="2020-12-02" version="1">MDMQDVKVLFDGYSKLEGGDYYANCSCVLIKGPHNVIVDTMTPWDGDKLLNALKEENISCSDINYVVSTHGHSDHTGCNYLFKNAIHIVGFSISHKDKYHTDPDFRNGEHYKINDKIKVIPTPGHTLQDVSVIVETDKGVLAVTGDLFEKFDDLDNEYIWLSAGSDSESLQRENRMKILKMADFIVPGHGTMFEVPKKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMN1</accession>
    <name>A0A6P7GMN1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 501-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114344528</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151161.1">
        <property type="nucleotide sequence ID" value="XM_028295360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMN1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028295360.2">
        <property type="protein sequence ID" value="XP_028151161.1"/>
        <property type="gene ID" value="LOC114344528"/>
    </dbReference>
    <dbReference type="GeneID" id="114344528"/>
    <dbReference type="KEGG" id="dvv:114344528"/>
    <dbReference type="InParanoid" id="A0A6P7GMN1"/>
    <dbReference type="OrthoDB" id="6609513at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002394">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028151161.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="47350" checksum="4B4FDC3238F8271A" modified="2020-12-02" version="1">MCKCKFMMEVKQEFSEDNCEIEIFSNDLDDALLESFKNEIKEEHLSDNTHSKFDHSHLNQFSLKTKIEVENNLPFEEKQTNEKGFPQDNDTLEMTKTIDIHCNKEKTMSRSSEEKTLTCEMSAKQFATKTDFNQHKKIQTGDKFCKCEICFKQFSHKIFLNTHIKSHTRQKPYKCEICLKQFIHKNSLTKHVRSHTGQKPYKCEICFKQFSQAGVLKIHLRVHTGEKPYKCEICFKEFSEGGSLKKHLRVHTGEKPYKCEICFKQFSVRGTLKNHLTAHTGKKPYKCEICFNQFSRSTYLKQHMILHNGEEANKCEICFKQFTRTDKLKTHLRIHTGEKPYTCEICFKKFTRTDKLKEHLRVHTGEKPYKCEICFKLFSDKGNLKKHNMSLHTGEKPYEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPE2</accession>
    <name>A0A6P7GPE2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114339218</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028145640.1">
        <property type="nucleotide sequence ID" value="XM_028289839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPE2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289839.2">
        <property type="protein sequence ID" value="XP_028145640.1"/>
        <property type="gene ID" value="LOC114339218"/>
    </dbReference>
    <dbReference type="GeneID" id="114339218"/>
    <dbReference type="KEGG" id="dvv:114339218"/>
    <dbReference type="InParanoid" id="A0A6P7GPE2"/>
    <dbReference type="OrthoDB" id="427071at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039210">
        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="218"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028145640.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37984" checksum="AB07D6FDCC48BDFC" modified="2020-12-02" version="1">MTSTTVTKRHREKNSAKATSQENWKGKAKDEITDKKDKESQPKDFKYGPLPRFPSQRVWSRGVMIIGVLVYLWYFSKSTNETVLAKQNTVYNRRSQVVECGPEFVEDIKQYKSCIPEKCGRFVSDKIVTDQEADILLRLAVRIMAQGGSSGGASIIDLHTGALSYKDRFINIYEQSGSKNILTESERTIYHLVRSKIQEAIAQNFGIQADSLYLTYPTFFSRLTNVDPKTRHDEYWHEHIDKRTYESFHYTSLLYLNDYGKDFKGGRFIFQDNIAKPTKNVTVEPRKGRVSMFTSGSENPHFVERVEEGMRFAITVSFTCDKTKAISDPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQJ0</accession>
    <name>A0A6P7GQJ0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-induced degradation protein 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114345221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151844.1">
        <property type="nucleotide sequence ID" value="XM_028296043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQJ0"/>
    <dbReference type="FunCoup" id="A0A6P7GQJ0">
        <property type="interactions" value="2377"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662497.1">
        <property type="protein sequence ID" value="XP_050518454.1"/>
        <property type="gene ID" value="LOC126892782"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQJ0"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028151844.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26324" checksum="81CD51B14E6046A9" modified="2020-12-02" version="1">MSYNTDKHDTPPTKEDWLMILEDNDLGRSSMNKLIMNYLVTEGFKEAAEKFQQESGVIPSVELHSLDDRIRIRDAIMTGKIQEATALINQLHPELLDNDRYLYFHLQQLHLIELIRNNRIEEALAFAQSHLSEAGEEDPSVLSELERTVALLAFEEPLSSPFGDLLAPSHRQKVASEVNAAILKMEHQENTAPQVSTLLKLILWGQDKLTKRNVKYPKMVDLASAKIDDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H5Q0</accession>
    <name>A0A6P7H5Q0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114344657</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151285.1">
        <property type="nucleotide sequence ID" value="XM_028295484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H5Q0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028295484.2">
        <property type="protein sequence ID" value="XP_028151285.1"/>
        <property type="gene ID" value="LOC114344657"/>
    </dbReference>
    <dbReference type="GeneID" id="114344657"/>
    <dbReference type="KEGG" id="dvv:114344657"/>
    <dbReference type="InParanoid" id="A0A6P7H5Q0"/>
    <dbReference type="OrthoDB" id="7468114at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028245239" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028151285.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15022" checksum="6857CD9FE55A47C0" modified="2020-12-02" version="1">MNFKMFKLLIVCVMTSMASAKPGGLGLGYGGYSGLGHYGVLPAATSYSSSVVHHTPVVAKTYVAPVVSKAYVAPVVSYSAPLVTSYGLGHGYGGLSHGYGGLSHGYGHGLGYGYGLGHGYGLGHGYSLGHSYAGLGHGYSLGGYGHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HA87</accession>
    <name>A0A6P7HA87_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein fork head</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114349412</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155582.1">
        <property type="nucleotide sequence ID" value="XM_028299781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HA87"/>
    <dbReference type="FunCoup" id="A0A6P7HA87">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299781.2">
        <property type="protein sequence ID" value="XP_028155582.1"/>
        <property type="gene ID" value="LOC114349412"/>
    </dbReference>
    <dbReference type="GeneID" id="114349412"/>
    <dbReference type="KEGG" id="dvv:114349412"/>
    <dbReference type="CTD" id="43383"/>
    <dbReference type="InParanoid" id="A0A6P7HA87"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20041">
        <property type="entry name" value="FH_dFKH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000042">
        <property type="entry name" value="hepatocyte nuclear factor 3-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047388">
        <property type="entry name" value="FH-like_dFKH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013638">
        <property type="entry name" value="Fork-head_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF380">
        <property type="entry name" value="PROTEIN FORK HEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08430">
        <property type="entry name" value="Forkhead_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028155582.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48214" checksum="CBD94FA0130FAA6F" modified="2020-12-02" version="1">MLTQKLYPDVNTMSTGSNAMSPMTTTYSMNSMAMAQMSCSPQTSMFGSGMLNSGMTSNMAMNRIQPRMDQPMSEPPQLGYSTIGSPISNMNACMGATMSSINNYNATIGRGDLGGGDTSPNSALQRARADKTYRRSYTHAKPPYSYISLITMAIQNSPQKMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFIKVPRTPDKPGKGSFWSLHPDSGNMFENGCYLRRQKRFKDEKKEILRATHKSPSHSVDSSSSSGKKTPVQHGEDKSHHLDKANENIGSMLSLHPAKLDVDQLNLLNANDLHNMQQHHHHQNMSHEELSAMINRSNHLALSSEHQAMLHHTPMNHHLKQEPTGYTPSNHPFSITRLLPAESKSDIKMQYDMQYAGYNTLSPLPNAIHSHSTIGNDYYNSPSLYHSSSGTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HFL1</accession>
    <name>A0A6P7HFL1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Co-chaperone protein daf-41-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114348097</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154525.1">
        <property type="nucleotide sequence ID" value="XM_028298724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HFL1"/>
    <dbReference type="FunCoup" id="A0A6P7HFL1">
        <property type="interactions" value="2405"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659986.1">
        <property type="protein sequence ID" value="XP_050515943.1"/>
        <property type="gene ID" value="LOC126890794"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HFL1"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028154525.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18888" checksum="FE6E90DF3617E29C" modified="2020-12-02" version="1">MTDQPLPPPVMWAQRSSIVFLTINLEDVKNPEIKFNKDSIYFKGTGGVEKKDYEVTIPLYKEIDPEQSKSFNKGRCIEIIVTKANTDGPYWPTLTSDKKKHHWLKCDFNKWHDEDDSGDEGVGGMGGGDFDEMMRQMGGLGGGAGKPNFDDIEGDEVGDSDDEPIPELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9Y1</accession>
    <name>A0ABM5I9Y1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 18</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128252.2">
        <property type="nucleotide sequence ID" value="XM_028272451.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272451.2">
        <property type="protein sequence ID" value="XP_028128252.2"/>
        <property type="gene ID" value="LOC114324585"/>
    </dbReference>
    <dbReference type="GeneID" id="114324585"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF13">
        <property type="entry name" value="OSIRIS 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047005743" description="Osiris 18" evidence="2">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128252.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26200" checksum="D8CA932985331F61" modified="2025-10-08" version="1">MFSVYFFVGLTILAATQASSPANPSAVELLQDVYYDCLQDFSFGCVKPKTLHWLSEVTSNQNIRITDNLMIVKKGGAESVQERGFSDDIFEKFEDFLQSHELVMSAPEFLPRSLDTKEIRVPLAVTGRSSKIVKKVIVPFLLGLKFKTAILVPLALALIALKTWKALTLGLLSLVLTGALVIFKFTKPKVVNYEVVHVPHHVEHHVDHPPSSGWEHPGYGRQLTANEMAYNAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IBP8</accession>
    <name>A0ABM5IBP8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028129337.2">
        <property type="nucleotide sequence ID" value="XM_028273536.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273536.2">
        <property type="protein sequence ID" value="XP_028129337.2"/>
        <property type="gene ID" value="LOC114325454"/>
    </dbReference>
    <dbReference type="GeneID" id="114325454"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="174"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="372" mass="40396" checksum="8FAF50ECC2B33C4B" modified="2025-10-08" version="1">MFIKTLNALCKCTSYIHTIKNYSSSSTAMKVTVIGAAGKVAQPLCLLLKQSPLIDELCIHDIGHTAALAAELNHVDTNCKVVAFSGTSEYGKALHNSKVVVVVAAAPDSDFMPPEKMWSSNATIVQDIVTNIAKYASKSFLAIATNPINSLIPMTCEILKKRGAYNPNSVFGVTTLDTVRANTFAARVLGLEPECVMVPVIGGNTEDTMVPVLSSTKPSPEYTTEEIESITATVRKARENMLKLKPPVNGHFVSAFACARLVISLVKAIRGHPDVIECAYVPSKAHPNVNYLSTPLLLGPSGIAKNLGIPKLSEFESCLLDNAVMYLRNDIQRGEKFVGALHTPECDPCDVMIPRCPKNWCDFQKEERNKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEH1</accession>
    <name>A0ABM5IEH1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131073.2">
        <property type="nucleotide sequence ID" value="XM_028275272.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275272.2">
        <property type="protein sequence ID" value="XP_028131073.2"/>
        <property type="gene ID" value="LOC114326823"/>
    </dbReference>
    <dbReference type="GeneID" id="114326823"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF47">
        <property type="entry name" value="CPAP1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046175703" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131073.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="921" mass="105994" checksum="2904A3587010646A" modified="2025-10-08" version="1">MKGASVLFFLGICTNWALAVFLNHRPFPTYSLENMPDTSFSCRDKILGGYYADADAQCQMFHICVKVAGIGIQDFRFLCPNGTAFDQDHQICAEWEDIDCDATTLYYSSDNFDLYRLGSGFESKPHKYGEDEETFALQRAETGDARINREQQAKVVDQTKQPKTFSAAPRQKYNNNNNNDREIFKSSSSSNFYNNRNNGKERDEDYDDNVNINQNQDYEQKRKVVRNKSRRPVQNRNEQNENSQNGNRNNEYNRNQNNGYNRNQNNEYNRSNQNDNSRKENRNNEYNNRNNEYNRNQNNNYNRNQNNDNNRNQNNDYNRNQNNDYNRNQNNDFNRNQNNDYNRNQNTDYNKNQNTDYNRNQNTDYNKNQNNNTYNNDYSKNNQSAQTRRPVTKFTGFVNNFAGSYEPTTSRPTSTTLNSEQYTTAINNYKSRNGQRRPQTSEYTDSPVYTISTPAPFRQQQYNPPPSRSSNNAQYTSAAPKQSTNYDDNYDIPKVKSTVAQDYNTQYDIPKVKPASSTGTQYNTQKTTVSQYETTKTKQTFKSPGSERTENYPSNNPKYTSNFEKKPTTPFKQNENYPTTLNPKPFSVSNNNNNNNNNNNNNFPTTFAPRTNAAYSQIAQQTSNYNQNRQNTQNSPSSFNSTPRSTPFTQYTPTVPKLSSTTPVSRSQFKLARSSDDLLDIKVLRSSRFDETQYDDGSYSSKYDYDGDRRDDEFLKTAHSQNIAASRNELQRTSNNKQQTTQSASQPSRTTYDVPKTYPSTPKDVPRINPSTSQVTKDTPRTYPSTALTKDVPRTYQSSQVTKDVPRTYPSTPQVTKDVPRTYPSTPQVTKDSQRTYPSTPQATKDVSRTFPSSSQATKGSSQTFAPTSQATESPKTSSQPVNKRPAPRKKDYDYAYYDTGVASEPDYEIDTEIKKSTVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEL6</accession>
    <name>A0ABM5IEL6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131144.2">
        <property type="nucleotide sequence ID" value="XM_028275343.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275343.2">
        <property type="protein sequence ID" value="XP_028131144.2"/>
        <property type="gene ID" value="LOC114326888"/>
    </dbReference>
    <dbReference type="GeneID" id="114326888"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="150"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131144.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="410" mass="47214" checksum="99514CD8B51075CA" modified="2025-10-08" version="1">MECGQLFSSFNEFNNILTQYEKDKRQKFVIKGSRSIKMTEKILKRKLKEDLKYYEVQYICVHGGAVRRRGKGIRKTRTYKMNCPAAIKLRATKTGDFLQIKQLVERHENHEMSEVVYDDLPTNRKLNANEQSIVENLMDVRENKKLIQQKILCSAGKLSTTKDLSNIAYGMKSSSNELEHVAKELKDIYTQDCKTRWRTLRDLYNRKRKLIKKPTGTAASMKASNWDYLDNMSFLRKFPKKKGSLTNVPGIGSLDPDEIRENDEETIADTEETEVEKVQESSNPKRSLEETEILKQNVNNKRNTDRVIAAMENRYKERNELFRELLSAPSASLAAPETNPIITFFQSMAQTVMTFPPHLAVEAKAKVCQIVTDLEYRSISQYQQPSHSSQLNALPRCDKSDSRSSSLDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJ13</accession>
    <name>A0ABM5IJ13_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133900.2">
        <property type="nucleotide sequence ID" value="XM_028278099.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278099.2">
        <property type="protein sequence ID" value="XP_028133900.2"/>
        <property type="gene ID" value="LOC114329087"/>
    </dbReference>
    <dbReference type="GeneID" id="114329087"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="6">
        <location>
            <begin position="1966"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="7">
        <location>
            <begin position="3100"/>
            <end position="3217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133900.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3236" mass="364550" checksum="8796DCA073528A75" modified="2025-10-08" version="1">MVFQSVLSYVLNKYLGEFVENLDENQLNVGIWGGDVELKDLVLKPAALAELDLPIQSVYGKIGKLVLKIPWKSLYTSSTVITVEDIYLVVQPNQQVRYDPVKEEQRLYDYKVKEIQRVEETKRAEDEKLAGKAPAKAGWTQEFAEKLVATIIKNIQLSIKHIHIRYEDKVTNPKFPFSFGVTLDQLIVESTDANWKKTIADDIIKIYKILHLENLAIYLNCKSSLYGDLPVTQMLSKLELGIASKEHNPDGFKYILGPINSSARLIMNQKPEIDQPPYTIPKFHFNLQMETLYIGMNKSQYRDIIALVDSMGRMTKGIPYRKYRPNLTEYKGHYRDWWKFAITAVLEQDVKRKRREWNWDNILDYRKKCRTYKELYSLSNQKKALKPEDAEKLKSCEKGLDLTNLIIIRQQVQAQAMKEAKEKGKQSWWDWAWGSKSNSSKDGSKGDIIDQFKKEMTPEEKQNMYKAIGYQENAAPAEYPEEFVDITATFLLKALQLELSDVDLTEKSVTVLKVDLNTVRCKLETRAAASAMKVQVKVDDFRGEGYREGDFIPYLITSEKAQQEGLLEVLFETNPLDKRCDQRVHVTALPLKIIYDANTVNKLADIFKIPPDSNLEQIADVAQSRLTDFKEMSSLGLQYAVEKRPLVDLNVDLQAPILLMPHTGKYTGNENILLVNLGRVKVFSYGRRCTATEVKRLNEEGKTQAEIFAFMKEHSYDNFKLELTNVQILAAERGENWSEALTTGKSKMHILNPVSLSITFSTCLITDDPRLPLNKVAGVIPSIDLVISDARLLLVIGLFTSIKFPGDEIPEAQPLRKAASSTLLLKYKEMQATGKNTKQLIANLADAEASVQFTTLSAEFEMSKLSVVINKQGTTAESAHQLAKFRVDTIKCDLKQQTYITDISLILGGIALEMERDSKIINIIETPRGDCKDDCSLFKVEFMQVDTKCPEFYSTYKSCESSLLLNFEVLNIILHQEGLLSLMKFGNEIQERIAEATEVKTSQDRIATIHSPGLAPGLATGLSTLASIAEEFTEELPKEIKKRSKRKKVTVQTIKFKISAALKEVSLKIATDATDVSRMAISGANATVIVKDTYTQVNATLSDMTVMDLNKRSVHELIMSRLEGDTLSAQVVMNNNEDVETDLPDMDITVQLGRSRIVFMNWYVSNMLNFLNQFQAAQDAIVEASQKAAEAARENMKEAYKKATKISLNVIVKAPIIMVPINSHSYDSLLLDMGIITLENKFLTLDIQNEEGHPAVIDDLKIGFKDLKMSRVLLDEHYGLVNEYYMLEPFNLNLSVKRNLSASWYQSVPDLDISGNIPSIHIMMGNIDYQRIMEILSGNLAEGKVEAVVKDPVEESKELAGAASLTASASVVSTKADVAKEIWMGATKQKPHIFLKFSFAMEKFTISLHHNLTDERSKVPGADKQQFAKFWLEGLSVKGRIMTDNSIVTSVLLMNCLMDDARPGREGKLNRIIDRSSPKDATYEFVDPKSASTKSMIDVTFQMKDNEMFADIRVFSFTIILSIEYLMKLAEFFKIPEEQEQEIKMISAGKSNVPTPKVKPADTPAAEQHMTINLKLEKPDIILVEHMDNVDTRAMILNAEILLKYRAAGKHQVVNGIIKELELYRCVYNPEHRPFTRCNVLHPLDISLAGSTPPEKGLHLELLVTSVYLSVSPATIELLNKTLATMTGGDEKDKENDEKVFEYDDLWKDSELKPEKLWYLNTEYGTDALALEDTCPADHGKVVLQELCIISIPSVTVTVEAGVGNKTLPMLMLETGFSGSVKNWSSQMILEAALTMQMGYYNSKLASWEPLIEPEVFNNKHIPWELKVEVTMNPEQPAIDNTSVLSPAESESEKCEIELPPPLMQIDLESEKNLELTVTKTLLENLQYLGKAFASALDKENIKTQVIESPYKVINALGEDITLLLEESSFTGPPSGVGDVNTLQDVPLELKKNLKENEKLHLGQELLSNSKRKSYTLKLEIPFLDSTLTLPVNRADKRYFPLNYRSSIHDNWALISDIRVEEAVTIITLRSTVQVHNYFNVPIDVYYMTSKGNQLLLVNTIKPNDKLNVPLKAVYTPTTELFFGVPNYSVTATPFTWKELETNLKVTKILQCYPKTGDNETMPFVIKAVGEMEQVYYEHTTRHTMASTCYNINLRPAVIFKNSLPYNVVCCVDESPDEFTVEPGDTLQLPTVDPGKNCLVFRIPEYLEKEWSCRKALDGEPEEFSVWSFESFDSATKMILDLGMYIVRKNDSLELMLYCPFWMINKTGLMLGYRKSKKCEKADSSSSPKSSDEALNVLYHPRDFQGPILFSFNAKNFFGKKKASVRVENGEWSNKFSVDVAGSSGFVNCKWNEQTYQIGVQNSLTHNGLTKQITFIPYYVIINEAPYAIECQEHNRPADHWVTVEPKSCTALWPKSDAQDKLMKIRVKGTQDSSAPFLYTESHNTLLRLNNKYGGVNVDIQLTEGTVYINLAPYEDGSAPALLVNHSNYTISYWEKDSVQKRELPPSTCCYYTWENPSGPRSIVWDRGNKKEIINDLRKDMYGEFAPEDGAHICWTSFLDGMQRVLLFTEDRALAEGAQASNILEVIQQEITVSIHGIGLSLVNNQARQEIMYLGIASSGVIWGSCKLSSTRFKFFDAKLSTALENAYQACLRESEINPNTDWHVQIDPKTEVDFKANMMYKPTKKIIRRTFLTGLWLNMKTSPSQKQIHAKINRLQIDNQLYDCIFPVVLAPVPPPKSVTANDGIKPFIEVSIVQLLMKNSQILQFKYFKVLVQEFHIKLDMGFVSSILEMLQEDEASAETEKQLFLTDKHHVEETLYALASTQSSQEQKSFYDLLHFSPFKIHISFSLAAGSSSSSQNISTPPLVHALLQGIGVTLTDLNDVVFKLAFFERNFTFLTQKQLISEATSHYVGQAIKQFYVLVLGLDVLGNPYGLVLGITKGVEDLFYEPFQGAIQGPGEFVEGLALGVRSLFGHTVGGAAGAMSKITGAMGKGIAALTFDDDFQRKRREKQNRKPQNVQEGLARSGKGLVMGVYSGVTGVFTKPVEGAKEEGVEGFFKGLGKGAVGLVTRPVAGVVDFASDSLDVVKRAAEGGEDTLRLRAPRFLHSDKLVRPYNLHEATGNRYLNHISKGKYAKTDVYVAHYIVVEKKEVLLLTDRRVAYLMHNDIFGGWQIEWSYTWEEITAPGKVTPKGVQITTSEKKKKLFGSSSNTKLVLIVSPQIREEICEKMESLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISL5</accession>
    <name>A0ABM5ISL5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140713.2">
        <property type="nucleotide sequence ID" value="XM_028284912.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284912.2">
        <property type="protein sequence ID" value="XP_028140713.2"/>
        <property type="gene ID" value="LOC114334813"/>
    </dbReference>
    <dbReference type="GeneID" id="114334813"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140713.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="448" mass="51188" checksum="DC1BF890DA1FF24A" modified="2025-10-08" version="1">MGRNKKPAILIPNNMRKKRRCNRSFLRASVIEAFQNLENEVPNRSNLTNTKFPTVNFVRRSGAARTHEVPKKITKNRPTLQPINEKTMITKDHKLVRPSISIVPLNKLERPSISLEPLDKLVLPSISVEPLDKLVRPSISVVPLDKLVRPAETISLVPLDRPVRPAETMSVVPLDKLEQPLVNNKNSSQCLNEKDIKLAVLDTPEEHQNDEDFKCIKDNKCKPVQPLADNRNTSQYLNERVNQLAVLDIPKEYLNDEDFKCIPDVSITLVQPLADTKNTSQCLNQRDNKLAVLDTPNEYLNDDYKCIKNISTKPVQPLADTKNTSQCFNETVNKLSVLDIPKEYLNDWDFKCTLDVSITLVQHLTDNKNNSQCLNERVNKLAVLDIPKEYLNDEDFKCITDVSTKCQLNESDMDVIEWILQNELDYSIIFPTISEKDQGDWNDLEPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ITH9</accession>
    <name>A0ABM5ITH9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028141457.2">
        <property type="nucleotide sequence ID" value="XM_028285656.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285656.2">
        <property type="protein sequence ID" value="XP_028141457.2"/>
        <property type="gene ID" value="LOC114335421"/>
    </dbReference>
    <dbReference type="GeneID" id="114335421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="976"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1426"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1666"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1736"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="980"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1688"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1736"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1826"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1838"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1855"/>
            <end position="1864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141457.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2001" mass="226685" checksum="E81C9FD29040178C" modified="2025-10-08" version="1">MAESVLRKQRKSNFSQDEVEVLVQTVGYYYETLYGEYSKKAANKSARHKAWLEVTKEVNSVSLEKRTLQEVKNKWKKCQHLYRPDDFLSLDYYTDEALDVSHVWEPLTELEDEDSMPLQQRLKAPATSTPPPESPEQVLQSQPLSPTKLKVTRHVKPSAPSPVQLPPPPPTPPIEEVCLRWNSHHSNMQTTFPSLLLREQYVDATLVAEGQTLKCHRVILSSCSPYFEEVLASISPYQHPVLFMKDVPFWTLKCICDFMYSGEIHIIQTKLDELLAIAETLKIKGLAGQKDAQTVDTKPDLTIPIKEEKNDEKKDEKEVKKKDEVKKKDEKEIKRKDEKEIKKKEEKEVKKKDEKELKKKEEKEIKRKDEKEIKKKEEKEIKKKEEKEIKKKEEKEIKKKEEKEIKKKEEKEIKKKEEKEIKKKDEKELKKKEEIKVPEIKPPKRKEDKEIKKKDEKEAKKKEEIKEVKEKKRTLSTPPPEVPVLKSRKVPKLVLHGNIPVLKSFGIRARGRPVGISKRSEKKLEKEKQPLSDKQQKIPITKDSPGPSFSNPYDLLKPVYEEVAKNLDPKPAKVVPTKETVRRTLQKKLKKRKISDTREESPPPTSSRKGRRRKVPKYSHPNPLANLDQSTIVREPHTDQAESFLQMQAMQAIKAEPLYEEAIEIEDNLVGFSETAVSVEEKLIGSLGRRTTRRSKQHIIMDVNKIANKPEEPILKIVNVAELKGPTDPLEDPLGLNQSSSDSTAIVENADNDLGFRISQVMTEKEDSRSSDVCREMGFQISSIVSEHEKDNKMDEVTTKIEAPDEEEEVFNEYEDSTSQPEDQKPILPILEEANKESANICRAIDQSDNSSLSRKTQEGITESVNTTQEFNLDNTTDITFKIKTELLTETENEPEISQEEEDGLLNAFDDEADEVEDHSTDPMEMGHESEHSIGHAHEIVTASNASLESEMITQIEVAENVEHVVSHPKCLDPVGVPTDESLSQQSLLDGSSSGETTLDNLRHSEVTEHTAERSTYATIDVNNESVINNEESASFLPLGTIAPSDNQLTPQDSLPSPKPSEFSLTNDDEKLSYVANTEVDPLNEDHLMDDDFNDDSNQIIETNDFVKSPQTINESLEKDLDILEPKIGPVSGCSSTQHSRDTSVETSLDIGSDKLENVSQPIDGNLETHEEIQAPEMSLFCANLSMEEDFRNENEESIEDRSVEQENTIVNFEENRLNSPKDNSPINTDLDKEINIPDSSNDLNDISNNENNPQFNDNLNEETRMDTPQENHKIDQQLALDKEGTSQIEECQDKEITPVAIRDTSPINVNQAQNKEDIGNEASEFGISENYDENQQIDYEKNSINMLHTEPDRQSLHSQPEKEEECLDLNQQLLLTENDQMEEEYEKEDYLHSPHGLSDQENLNMSQENQMMEEEYDQEMLNIQQGDFGNDNNTPQESQLLMDEDKPPDVNQVPLVDDGFQTESGSVAMDYEEEENNAIVEPETTLDENKINFNQGDSSNIPQYDTTESMQEDENKIDFNQSHSSNIPQYDVTESMQEDENQINVNQSHSSNIPQYSIAESMQEDPTNIDGSVNNENSLNTEMLDENTELNTPAVETCDISNMPESLPHVENEALDEGSSNLTPISEPLYSTNTGDDEMDTNIIPFEEEQHCDNNDKIMSMNDGIEPPVYDSDPTLLTQPDIPPFEVSQSGDNSNNLGMPSSSVTAFDTLDNETDNTSPVVDPYLQNFNQIQTESLQTDEASGSNEPDSPTAHEVNEQSSSIEPDFQIDRSNEPDSPTAHEVNEQSSSVEPDFQIDREVSEQCSSNEPEFQIAGEINEQNSSNESQDHIFHVENEESSSNDPAFRNEASTLNEPDFHTAHEVSEQSSSNAPDLQIAHEELNEQNSSNEQDFNITRVVNEQSCSNDPEFSSAQPGNEPGFHIAQVVNEQIAEIEGIRDKRQLVGDNSDTNERCEKVNTSSDLESIVNDLSQMVGDSCGVTDLPLTDDTNSIADSLENLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IU15</accession>
    <name>A0ABM5IU15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141906.2">
        <property type="nucleotide sequence ID" value="XM_028286105.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286105.2">
        <property type="protein sequence ID" value="XP_028141906.2"/>
        <property type="gene ID" value="LOC114335816"/>
    </dbReference>
    <dbReference type="GeneID" id="114335816"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141906.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17498" checksum="1CAEFBAE40BDE390" modified="2025-10-08" version="1">MLDLAVSATDIGVVRGEALNANIYIQRCLSKLLQFVNTHHANDQIVFWPDLASCHYARITRDWYETNNITFVPKPDNPPNLPQARPIEEFWAILSRKVYNNGSEAQNQEQLRRRIYTKIREIDAEVVQRMMQRVRGIIRQIENNGPFSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWL0</accession>
    <name>A0ABM5IWL0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145524.2">
        <property type="nucleotide sequence ID" value="XM_028289723.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289723.2">
        <property type="protein sequence ID" value="XP_028145524.2"/>
        <property type="gene ID" value="LOC114339082"/>
    </dbReference>
    <dbReference type="GeneID" id="114339082"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047001253" evidence="1">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145524.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="199" mass="22010" checksum="C6C8B5552A8F11F5" modified="2025-10-08" version="1">MSSTKILLVSITLLGCFYFAHAQQPQISGAEVNDLKAAWQIYNKNPIKYATELVNTVVDHVVIPVVKANLKLLDVVLNQEAQAKILAALPHLKEIVNVELFKFLVVDGASVINMSLDAILNIVVPLLNDLEGSLKRYAGVILDIIIQIGDDVLGRLVKLAEQHMRGDLTDAQVKAVVKDIKIIDFIDKPMLVRVLRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHE1</accession>
    <name>A0ABM5JHE1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497354.1">
        <property type="nucleotide sequence ID" value="XM_050641397.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500971.1">
        <property type="nucleotide sequence ID" value="XM_050645014.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641397.1">
        <property type="protein sequence ID" value="XP_050497354.1"/>
        <property type="gene ID" value="LOC126878589"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645014.1">
        <property type="protein sequence ID" value="XP_050500971.1"/>
        <property type="gene ID" value="LOC126880938"/>
    </dbReference>
    <dbReference type="GeneID" id="126878589"/>
    <dbReference type="GeneID" id="126880938"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="647"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="731" mass="83399" checksum="0E0403C2C7BDA341" modified="2025-10-08" version="1">MSFFEVGKKEPTSVSPSSSATGEESKDNLTEQSNSIERCPKPDESDRLIVTNLKWPSIWNQEMWERKKQAFPWIDCREGKLGCSVCKHVSHLGANKTERSSIAKEWCSYQVTSNGKTKAAQLRSLRKKMFIHKTTSSHKAAKKIIEVSKSQTIEKVTDVMNVSHLETTKVIFRTAYYLAKSNRPYSDFFDLLELQRMNNVDVGIGLHSRNTAVEIIDHVSSEMKSKIIKSILNISGKISVIIDESTAVGSKSNLIVYLKCEFSKEQNPHFLFLELIELSSQTSQVIVESLLSCLKISGFDDDYLKENFVSFASDGASVMLGKKSGVAERLLEMYPDIIVWHCMNHRLELALSDAVDEVGAVNHFQIFMDKIYSTYSKSPKNQRELSECASKLEQQLQKIGKVLGTRWVASSYRAVSAVWYGYSAIYNHFEKAKTDKNRSSTERSMYCGLSRQLSSLQFLLNLAIMYDILAELSMLSEALQNRETTVVYADKLIRRSIRFFETLKETPGTKSLEAYIAEKDGNFNNVPITNNPKIATINHKQVITSVINNLTRRMFTTKSSHESKSSASSNCKQQYDSLLSDLKVLETDQYPTDKSVRYGEEQIQNLCKRFKLNKAKITNCFRDYIEANSPSRIPKDLIPLLNCTKLIPCSSSECERGFSLMNQIMTDLRTRLLTRHVSSLMFIKQHGPSITEWNVEPYVNTWLRRHRTADDTRTRTAKPYPEEENPFVQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHM8</accession>
    <name>A0ABM5JHM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic FMR1-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CYFIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497441.1">
        <property type="nucleotide sequence ID" value="XM_050641484.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641484.1">
        <property type="protein sequence ID" value="XP_050497441.1"/>
        <property type="gene ID" value="LOC114336529"/>
    </dbReference>
    <dbReference type="GeneID" id="114336529"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="3">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1287" mass="149866" checksum="2EC70CFF83FC0499" modified="2025-10-08" version="1">MAGNERVSLNDALSNVEVLDELPLPDEQPCIEAQPCSVVYQANFDTNFEDRNGFVTGIAKYIEEATVHASLNELLDEGQEHAVMLYTWRCCSRAIPQPKSNEQPNRVEIYEKTVEVLAPEVNKLLNFMYFQRKAIERFSQEVKRLCHTEKRKDFVSEAYLLTLGKFINMFAVLDELKNMKSSVKNDYSTYRRAAQFLKVMSDSQTLQESQNLSMFLATQNKIRDTVKENLEKITGYEELLADVVNICVHMFETKMYLTPSEKHMLVKVMGFGLFLMDSELCNINKLDTKKKLRLDKIDRIFKNLEVVPLFGDMQIAPFNYIKRSKHFDANKWPLSNSTTPSPQADLMVHLPQIREDHVKYISELSRYSNEVTTTYKECGSDTENKETADLALRGLQLLSEWSSVVTELYSWKLLHPTDHHQNKECPKDAEEYERATRYNYTDDEKFALIEVIAMIKGLQVLMARMETVFTDAIRRNIYAELQDFVQLSLREPLRKAIKNKKDLIRSIIMSVRETCADWSKHFDPINDHLLKGRKDPETGFQIKVPRRNVGPSSTQLYMVRTMLESLIADKSGGKRTLRKDIDGQYLMQIDSFHKTSFYWNYLLSFSEYLQKCCDLSQLWYREFYLEMTMGKRINKCTVRHNHNEECSDLITMEKRIQFPIDMSMPWILTDHILKTKEPSMMEYVLYPLDLYNDSALYALTIFRKQFLYDEVEAEVNLCFDQFVFKLSEQIFAYYKQLAASIFLDKRFRVECSAVGAYLLPYPRANRYETLLKQRHVQLLGRSIDLNKLITQRINADMQKSLDLAISKFEGGDITGVIELDGLLQVNRLCHKLLSKWLALDDFDSMFREANHNVLAPYGRITLHVFWELNYDFLPNYVYNAATNRFTKYRGISFGTAVSRDRPPQMSHHYLWGTKQLNLAYTTQYSQYSGFVGPQHFHTMCRLLGYQGIAVVMEELLKIVKSLIQGSLLQFTKTLMEAMPKICKLPRYDYGSPGVLGYYHAQLNDIVQYPDARTELFHNFREFGNIILFCLLMEQALSQEEVCDLLQAAPFQNILPRPFCKDGEKLEAKQKRLEAKYQALQIVPNIEKLGTAKQAMISKEGDLLTRERLCCGLSIFEVVLSRLRSFLDDPVWVGPPPTNGVMNVDECTEFHRLWSALQFVYCIPVSENEYTVEELFGEGLHWAGCTMIVLLGQQRRFEALDFCYHILRVQRVDMKDEVVKGINLKRMVDRIRRFQVLNSQIFAILNKFLRSGESDELSVEHVRCFPPPIHPSINPQQHYHAPEHLRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI20</accession>
    <name>A0ABM5JI20_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497588.1">
        <property type="nucleotide sequence ID" value="XM_050641631.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641631.1">
        <property type="protein sequence ID" value="XP_050497588.1"/>
        <property type="gene ID" value="LOC114329209"/>
    </dbReference>
    <dbReference type="GeneID" id="114329209"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057734">
        <property type="entry name" value="UBE2O-like_SH3-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23044">
        <property type="entry name" value="SH3-C_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="832"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122577" checksum="12DAD2CDF27F8389" modified="2025-10-08" version="1">MSNSNIEKVKEFYTNDVVYRFDKHKRIIFGVVVDSYEACSDVDEYHALQKGQIRVLWNNSSREQVWRQSKVRLVNRSIIPGDIVRRLEKGKETQRGYCKETKQVATVQIVGTDKVIEHVSSDRLHGVRPFDVDDAVCLGSKFGRIETVEQAIAMQSKCGSVVEVLTSINHDMDDYWLSKRNRISFDAYYPGQELICVPNNFEQANWIKKSKTMKRNIQSRQRFTVQSVEDVLIEIAWYNNTHGYSHLSEIGRADIKNLKVLERASDTFLELTDRRLLKLSSSDILLKKKDWTKKLSLVYRPELPKVRHIVSCNSKISRLSKLSRSALVYSQSEDVITNNDEEEWWTEESEESEDADVSQISHNSKPKKKHYPPKPRDLVPGNSLAVEVICVESKVSVVWQDGTEEKDIPSTHLYYSISLDDHEFFPGEWVINDSKIESDKYGVVQSVNYLERTASIKWFTYSENEKKPTELAITEMSVYDLVKHSKFVFRPRSIVKSKPAQDEKMGKVLDSCIEGYVKVQWLDGKEENCWPQDIELIPETTDYDFSDEETSEEDAACVSWETESIESYAGDLTDETVLQNLAARLDFVRNRIIYLKDAFKQHTILETFVFVKDLLLIYENSSYLDKLLGTSYFSLKSKHFQVLLLQAKEKAKSLGVELRGRLFSCDNFCPSIAKIKVAEKENINKMIKLENKINAQIEKKECKDSTAPSTPLTPDSTEISSSATQDNLCVELLSMLKVRMDLAYAEIISRIGGSQAFTVLTKASENVATPSSSTPLPSVPTTPDDSFSSLSPLKSKFLTRTSGDNEPYTLIDDAPVTHHYYGTKFEPTDLQRFLKSIQKEYKLLKDSLPAGVWVRSYGNRIDLLSVMIRGPDKTPYEDGLFLFDIQLSTDYPRSPPLVHYISYSSERLNPNLYVEGKVCVSLLGTWMGKGTEVWGPNSTLLQLIVSIQGLILVSEPYYNEAGYEKQTDTQQGYENSRTYNELVILKLIQSMKEMLQSPPEMFKREIIAHFSESGHKLCERLRGYCRNENPLNPEFPLLPVSKGLKLSLASALDTFEGVLNKIGDNTTEVPNETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIZ7</accession>
    <name>A0ABM5JIZ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein DDB_G0290503</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497914.1">
        <property type="nucleotide sequence ID" value="XM_050641957.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641957.1">
        <property type="protein sequence ID" value="XP_050497914.1"/>
        <property type="gene ID" value="LOC126879064"/>
    </dbReference>
    <dbReference type="GeneID" id="126879064"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24664">
        <property type="entry name" value="Monjiviricetes_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046412104" description="Leucine-rich repeat-containing protein DDB_G0290503" evidence="2">
        <location>
            <begin position="19"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="89645" checksum="396D7E0D0B2860D4" modified="2025-10-08" version="1">MRSLLFLLLFYTWQISFAQKCSSPEVSRKLSFIYRTVPSSQIEVVECFYTDGNSKNDYYDITKNCVTAARTRIFIDKYGDDHRVNEGGSKVSLKTYYTNADLSQNVVFLKSGKKCRYDAGFCYDPSQGNNYAVVWAVNPVPKVVCPNQLEQIFYGYVDYWTFTAENRKYLIYSVPLKDESFSLSLSNTTVCHGKQAWYVDEQGFLVSFTSLLPRVTATPVLNRNLFPTFKSKGDISDSIIRDCTLKSYNLNFDTKIDTDYLSDSENLKIILRFYQQNIDNNKNAINKLAKDIQDDNRDKKPSENVLSEINQIKSSLSTNFNNINKLFKDINQLRTVDTDIYSTITNLANSIKQLKIDIKDFTVNNKYLDKYLNELKNDFNKKLLDYNTNIKIQLDKLAHSSGSNVINKLNPAIQSLNHSSTTCLNRVTILKQDTKMSIRQLKNDLMVTQDSLETNVKKFILANLTNIEMVFGRKLNDVLASANKKCDKSLNDVTAFKNILKNDLATLEGKLDKCSIDQKTTSNELKKVEQALSARISSSSNDIKQLNDSLYNYVNMSISSLTDATNKDFSKELSDLKRSLSGRLSNDESRLSEVEKNVQKLRSDFNEKGNSLDTAIQGIKKDILVLQGPNDELAQTVEAGVLAKVIPLLNPTLITKNVSRELGGLKDEVAAQFADSSKTIKDLKTEVDSCKRVSGTKLKENEKKIGQIENNLSRTQMTLIDLSERLNNGVLDQVNSRVTSALDKTARCETEVKHLQNEINKLRNDFETTVAMLKAEHDYFRNQLQPTDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJI0</accession>
    <name>A0ABM5JJI0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498093.1">
        <property type="nucleotide sequence ID" value="XM_050642136.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642136.1">
        <property type="protein sequence ID" value="XP_050498093.1"/>
        <property type="gene ID" value="LOC126879142"/>
    </dbReference>
    <dbReference type="GeneID" id="126879142"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045665356" evidence="1">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="45553" checksum="D19B714F8E00144E" modified="2025-10-08" version="1">MWLLLCTLFLSWLSLVKLQNSDNKNVTANITVANITVLPKNLSGGPFKPIQVIERRNLLLNTTEHLLNETNIKKIDDFKPSPQIGGFDNSFFLNQQSKSFESYPAPNWAANVWSDNSVRHEESSIESPWKNTPVKFPAPTEARPYPFGSGYETPTTVSNPIELVYKQPLQPPVRHQVPPPPQIYPQRQPEGGMWQKFLSFAGLDKKFPVSSPKSFYSDHGSYPGNQLDHSGFPGEYLDPHSFNEGNKFDHSYHGYSYGPKEPHHSIEPHHGDGGISPFKKILKVLAAIIPIGLFLSALTPTIITVSSANDTTGRFNRNDDTSENLLTKVANSLNSLNKLQQDGCQQKVFCELMVNAMFSTNAEEHIKNLLDNFVDKSGTNEDTFTTVLEAVKNQDCSTLSCKDMADPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLZ9</accession>
    <name>A0ABM5JLZ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRP12-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498963.1">
        <property type="nucleotide sequence ID" value="XM_050643006.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498964.1">
        <property type="nucleotide sequence ID" value="XM_050643007.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643006.1">
        <property type="protein sequence ID" value="XP_050498963.1"/>
        <property type="gene ID" value="LOC114330504"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643007.1">
        <property type="protein sequence ID" value="XP_050498964.1"/>
        <property type="gene ID" value="LOC114330504"/>
    </dbReference>
    <dbReference type="GeneID" id="114330504"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="114"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="438"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1130"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146856" checksum="6BC3A7A52A48B71D" modified="2025-10-08" version="1">MGKFRSKLKGQTKGKRWPKGQSSSSNPETKKYRDLAKSRFFQENLGPSSLTSDALKKHDAVQSYIPKAPESINMEEDTESSVGTQSSFGTMKSFASEWSDCSNMSFNRFLTVFRSDSALHKEMLAILAAITEVIKENGGSETPTEYFGSLMTTLEQVYNAENKNEDQVTAVLALLNMGIKTVPEAVLKKHFNDITLKILHILSDYADSENNTIMKSIFGILGSLLKIQELAVWNQPSTIQIFNALLNPFCIHTKPKWRKAAQHAVMSIITTGNFVKEGSSNPAADRAAEFCEQTLDSCMGSTSGVVLVSSVQAGQTTILHVLGLLKEIISKFSKHHIKTCCETILKLMTLNYPIVTSCGMQVLYALFSAQTAVIPGKLNAQLITALYEYQPSLSDVQPTQAWVTVMQQAHVHLADVDVALAMATLPKIIDIFTQLWLSEKAEIMTSATHALEILLKDALVNGCSSKELVGQHRSKVERCIQTIQLCLGYQYNASWHQVLHIVSVLFEVTGANCSDMLLGLLTNLAELRDSYKFSYNNELEHAVGAAIRSMGPEVVLEVITLKKPNGDLNIDRSWLLPVLKENIKCSTLEYFVKGILPLALYCHRRSAQLAQNNDGIGAHSSELLYLQLWNLLPCFCSQPKDIKDSFKTVAKVMGTAISDKKELRLAVMAALRRLISYAKESENQEDLQEISRFDKNYLPILFNVYTTKPIGTDEEGQRLAALDTIKLYLSIARPELTQQLFNNAIERLNSSSDEPEDHFIKESILDLIRALVPYQNAQNVEILYQQCIQNLPEIKNNKEQKKAYRLLEEVCGSESEGCQTFVKSNRKEVQRLLMKSLNSAAVSSKGARLRCLNYLIKAQPQLDNESKLIKSAIPEAILCCKDINEKCRTTAYDLLNTIGNLLLEHDKMQQFLELIIAGLAGTPQLVSCTVLALASILHHFSGTLGMDNIRIIVDNVCTLAGSPTREIVASCLSFTKVYITTLPSPMVASSLEHLMKGLCNMTEDCKRHFRLKIRDILDRLVRKYGCESLTPFVPNTDTVMYKRLRNLRKLNARKKRRKDEDREDESDDEEFTVKAKPKSVEEILADSDSEFEDMETDEPKVKNKKQAKTWIEEDPDNIVDFIDPSVISKITATKPGLVQPTLEKKKPEKDRGFKTAPDGRLIIKDDSSSDSDDDKKLKFSDDSDDDDDTQSKVETVLLTDRKRKRSNASVKSGFSSVSSQPPMKYKTGGVGIHRSLGASTSSVKSGFSSAGSEYKSRKASGDVKKKGKLDPYAYLPLKRTTLNKRKKNKAAGQFKHIVKAAKAGALKGAKAKRNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMN8</accession>
    <name>A0ABM5JMN8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499204.1">
        <property type="nucleotide sequence ID" value="XM_050643247.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643247.1">
        <property type="protein sequence ID" value="XP_050499204.1"/>
        <property type="gene ID" value="LOC126879902"/>
    </dbReference>
    <dbReference type="GeneID" id="126879902"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="122"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="406" mass="47803" checksum="C6211314B8C48647" modified="2025-10-08" version="1">MFELTEHHKQLIDEVARKKGFTDYELTVAPCLSKGGNFMGIVSAVTIHNSEKKMEVVLKSAFSYENEKPPKMLSEAYKREIYMYTRIFNEFFKFQEEYGIIEPFNSVTKIQNYSDVEGSQCLIMENLKTGGYQLWDKTIPLTPEHMEKVIQEYARFHAVSFAMKHKNPKLFEELTSPIERSIFDNEDMISSVDKSISYVTTLFKNVYEAIEGDTHLTEYAKEIETKLPQHLWEGIRRKDVKCVVSHGDCWCNNFMFKYKEPQNRVTPSKICIIDWQLASLNSPLYDFAYFFLVHADKETLNKYEEYLDLYYNTLSKQLENFDCDPQEVFPYATFEEHANFYGFYQVLIAIIVLKIMLCESEDAPEFSDALEDMDKMIAGMEFDVKNKEVYHNRLKDLFEFLNSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNV0</accession>
    <name>A0ABM5JNV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050499612.1">
        <property type="nucleotide sequence ID" value="XM_050643655.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643655.1">
        <property type="protein sequence ID" value="XP_050499612.1"/>
        <property type="gene ID" value="LOC114331495"/>
    </dbReference>
    <dbReference type="GeneID" id="114331495"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="707"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="912" mass="102998" checksum="5320A2A50F0EDC5B" modified="2025-10-08" version="1">MHGMMKIFSNFKDFYNDINGATLTGAIDVIVVEQPDGSYNCSPFHVRFGKLGVLRSREKVVDIEINGEPQEIHMKLGESGEAFFVEELEEDDDEEIPEHLATSPIPVSDFETLFKKQGRRLSLEDISNLGLENEENDYKTRRNTADNESNKMRERNFIRRQLVLGNLEINNENSAEEMTLSIISGKLSSEDLSKSHNDISETIFKMDSLDIDISKTEELKSENLVSPVSNLPKIDDPTNESKSSKKRRKRVRRKNAPKKSSSINQMTSSQISENLETNDTITDRSSLDSNGSDPELQGKSSKKNDDNVLRVDTSHIKKIDADFHFFSDTELTKPSIGDCRTGSVENVENVQSDSEIEVKARKDEPLDNAKSWEWGGFPSVSQTNSPVSDNPRQEERRSMLSGMFSFMQQKHGAQNPLEGGMYLSDITSGTVDQEVAQIYFSTTKDRKDVEVDCESGNGPSLTQSPNSADGCKSIDSDFEEQNKLAQSFSQEISLSLCGWDPEPNYNRFLEKVVKFSDLCNNPILFENPNLVVRIKDKYYTWKVAAPIITSIMVYGRPLVQSSVDQLCSIHMPISTPQELKEGPKQEVGRRSWWSWRRGGASRETTPAPENENDALKTADTKDVVIEVDDDSKLEDKNEDVNEQIDVPRSPSSSSDKYRKTLRLTSKQIVLLNLRDGMNEVEFSVTTAYQGTSRCQCHLYKWKWDDKIVVSDIDGTITKSDVLGHILPIVGKDWAQTGVAQLFNKIEDNGYKLLYLSARAIGQARITRDYLKSIKQGDLSMPDGPILLNPTSLITAFHREVIERKPEQFKISCMSDIKALFPTDSNPFYAGYGNRINDVWAYRAVGIPIVRIFTINPKGELKHELTQTFQSSYPIMTVIVDQLFPSRSEAASDFSQNVYWRDPIPTIEEVPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQ72</accession>
    <name>A0ABM5JQ72_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500085.1">
        <property type="nucleotide sequence ID" value="XM_050644128.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644128.1">
        <property type="protein sequence ID" value="XP_050500085.1"/>
        <property type="gene ID" value="LOC126880323"/>
    </dbReference>
    <dbReference type="GeneID" id="126880323"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="101" mass="11988" checksum="FB1CB0C053AFF7A2" modified="2025-10-08" version="1">MKVHTGEKPYECEICSNPFTMRCHLNTHMKCYSSEKPYKCEICSKMFTREDDLLMHMRIHTGETPYKCEICSEQFGRLSGFNYHMKVHTGEKPYTSDMLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQN7</accession>
    <name>A0ABM5JQN7_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">E3 SUMO-protein ligase NSE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E3 SUMO-protein transferase NSE2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-structural maintenance of chromosomes element 2 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_050644295.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050500252.1"/>
        <property type="gene ID" value="LOC126880439"/>
    </dbReference>
    <dbReference type="GeneID" id="126880439"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="15">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="229" mass="26473" checksum="ACA61F7DFBAFB0FD" modified="2025-10-08" version="1">MSSMQKTDDVLEKVTKSLKLWKKLISDVCENDETKQNQLNILETHVKEYSELEHNFNTTSKAFQNLDEKLNSSEKIEDIESLYQDCVDNVTTGSSINHQKSRVWQTIFKGNADVREVHKKSKKLQDTQYDTIDESLLCSNVFVPPLDPISKTKVKNPYKSKKCGHIYEFDSIASYIRSQGKKAKCPYIGCNSEQLRMTDLVRDNELQSQISQYEETHVSEEEEEDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JR95</accession>
    <name>A0ABM5JR95_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500463.1">
        <property type="nucleotide sequence ID" value="XM_050644506.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506294.1">
        <property type="nucleotide sequence ID" value="XM_050650337.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506295.1">
        <property type="nucleotide sequence ID" value="XM_050650338.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511251.1">
        <property type="nucleotide sequence ID" value="XM_050655294.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644506.1">
        <property type="protein sequence ID" value="XP_050500463.1"/>
        <property type="gene ID" value="LOC126880560"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650337.1">
        <property type="protein sequence ID" value="XP_050506294.1"/>
        <property type="gene ID" value="LOC126884427"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650338.1">
        <property type="protein sequence ID" value="XP_050506295.1"/>
        <property type="gene ID" value="LOC126884427"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655294.1">
        <property type="protein sequence ID" value="XP_050511251.1"/>
        <property type="gene ID" value="LOC126887657"/>
    </dbReference>
    <dbReference type="GeneID" id="126880560"/>
    <dbReference type="GeneID" id="126884427"/>
    <dbReference type="GeneID" id="126887657"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="829" mass="96756" checksum="B94CE9C1216679FD" modified="2025-10-08" version="1">MNRCTKCNINFTKYYNMRAHAKRKHPDMLDILLPNNVQQSKSTVPCLECNKKFSNLGNLRLHVKRQHPDKLDEIAPVNKKTYVCSSCSESFHNLKKLVSHKQTHNNALTKLKCTLCQYNNSGRENLILHYRSDHFINIENNYLEFDTFEDFESWKCKVEEETFSSFVKMYGSKKTSNCTTTNYSCHRSGIYKKKGMNIRKLKIQGSNKINGYCPARINVKLMDNEKYIVNFCQTHVGHSPEQDLGHLFLSKSDKQNVAAKIAAKIPFQIILDEIRDSVSNSRLERLHLLKKKDLYNIEKCFNLCSSSVRHENDAISVDAWVSEMKSSECVLFYKPQETICQENPELQYEDFFLIIMSDGQKDLLLRFGEDCICIDGTHGLNAYGFELHTILVLDDLREGYPTAFLISNRSDSIGMKIFFQCIKERVGKAIKPKVFMSDMADFYYKSWMQVMQPAEFRLYCTWHVDKAWRKNLEKVLNKEKKVQVYHMLRTLLQETDSTAFNQLLLNFLKYLKEDSDTLEFAMYFEQYYACKAEQWAYCFRLHCGLNTNMHIERMHRTIKHIYLHGKFVKRLDKAICAIMKFVKDKLFERLIVIHKGKVSTKINELRKRHVTSQSLDLNKVIKSDIGWLVPSNSRNEMYTIQKVKENCPCRLVCEDCEACLHCYTCTCLDSCIKWNMCKHIHLICKYTQMDLTKESTIPNINFLAGDADNLVIECDDEKRALIGAVSKIRRNEESSLKEAKEKLSLKITGQINDLESFDELKAVQKIVVPIKPTIDAIRNQKDINLGFPSTRRISSNKKIFPQRNFFPTKKIKGKKRSKLPKPHHQKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSH7</accession>
    <name>A0ABM5JSH7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dipeptidyl peptidase 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500891.1">
        <property type="nucleotide sequence ID" value="XM_050644934.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644934.1">
        <property type="protein sequence ID" value="XP_050500891.1"/>
        <property type="gene ID" value="LOC114331068"/>
    </dbReference>
    <dbReference type="GeneID" id="114331068"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="13">
        <location>
            <begin position="14"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="12">
        <location>
            <begin position="528"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="85129" checksum="B71199A621E8B536" modified="2025-10-08" version="1">MFRLRLNPSRFQLSPDQKYLLLALNVQKLFRHSYLAQYSVYDIQTGNDFPLRPIPEDDDHPFLLLAQWAPKGHALVMVQDYNIFYRKTPTSHTGYRVTHTAVPGVVSHGVPDWLYEEEILGTNSAIWMSRDGMLMVFASFNDSLVEELRFPWYGSIKDGRLYPDIRSLRYPKPGTRNPQVVLTVADLADTSNIKMKPVIPPNVIARNDHYFTAVSWISSTEISVVWLNRPQNLSVITICSSPKWDCRETQRITGDGHGWVDMSDSPVFGTDSSNYITIAPVRDGPAGTFRHAVAVNIPKRRFIPLTHGRYEVTRILTWDHSNDVIYYLGIPEGKPGQLHLYRVASVPPRTGASLPPPVCITCVKEPAPTQPPFIALDENIYRVKTNSWDEDDEDIVLTTPPTRKRRKKQKVVEKEPPCLYHNVVFSPNSAYYVLECLGPGIPTSILYKTGMPKSKILMWLQNNTELKERVEEMAMPQIRTFPVQISGGYQAHVRLHLPPGLREDEITRYPLIVQVYGGPGSQLVTERWRIDWNTYLSGNKDFIIAQIDGRGSGGQGHQILHKVYYKLGSVEVADQLEVTEYLRDTQHFIDKRRVAVWGWSYGGFVAALALASPKNVFHCAIAVSPVTNWKLYDSAYTERFMGLPNVTDNYKGYEEADVSKKAHLLKDKMFYLIHGSADDNVHLQQSMALVKALSEAGTLFRQQIYPDESHNLGGVKRHLYESMGNFLEDCFRKQVPPEFKAGLRNYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUJ7</accession>
    <name>A0ABM5JUJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501608.1">
        <property type="nucleotide sequence ID" value="XM_050645651.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645651.1">
        <property type="protein sequence ID" value="XP_050501608.1"/>
        <property type="gene ID" value="LOC126881396"/>
    </dbReference>
    <dbReference type="GeneID" id="126881396"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="470" mass="52930" checksum="B83DED054720F973" modified="2025-10-08" version="1">MCTFQPKHLLVKEVDYELRIREIEVEESAKCDKKRSLLRGALKQEQGNRSFRQISAAAIPFLEQQQGINETLEDLTQKINNFRGTVHDSMYSRYISRLAHISGRVHLLCCSDEEQQLYKRSMSIRILSLEGELDSRVNPLATSTPVSSVQASNSLLHPKPVQVHKWGVSFSGEGHYDQVISFLDRVECLRVSRGVSEEDLFSASAELFTGHAFTWFMNNRGSFTTWTDLAQKLKSDFLPYSFQTDLLDEIKNRKQKPGESVTMFINTMLGMCSRLDTPLTDHAKIKIILKCLLPFYHAQLALVDIATIEDLTEKCKRLEETLSWSLNSPTTSQFNSGPVGFNSQPSRNRSWQSRPHTPNVSVTTYSLSCWNCQVVGHTFRDCTRPQTRIFCHGCGRENTLKRNCFKCSGNEHAEARTLSVPQTATPSGNMTAAVDEASGPIPASSSNTPSQEGRNTSNRRPARQPKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUK5</accession>
    <name>A0ABM5JUK5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501619.1">
        <property type="nucleotide sequence ID" value="XM_050645662.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645662.1">
        <property type="protein sequence ID" value="XP_050501619.1"/>
        <property type="gene ID" value="LOC126881401"/>
    </dbReference>
    <dbReference type="GeneID" id="126881401"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="24"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="368"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="754" mass="85684" checksum="E7F3AEDE8F29D221" modified="2025-10-08" version="1">MMTPETPSSSGSDTSKPGCRSEERLMVAVRIRPLKQDESTRALYALNKKTIILEDADKSDAIRQKKGMEKQYSFDVVFGEDSTQEEVYKVTTKNLITDVLNGYNGTVFAYGPTGAGKTHTMVGTRSAPGIMIRALNDLFEAVKDKEDEYSVTMSYLEIYNEQIRDLLNPSSGFLELREDSKGKSMQVAGLSEVSTNSTDEIMQLLHKGNKARTIEPTAMNQTSSRSHALLSVTVRHTIPVNKTDHLRIKIRQGRLFMIDLAGSERANKTKNSGKRLQEGAHINRSLLALGNCINALSGGARYVNYRDSKLTRLLKDALCGNCKTVMIAHVSPSAGQKEESRNTLIYADRANNITTKIERNVFDVSYHVTQYQTVINELRDEISRLQHKMKEERPRSADVKKLNAEERRNEVQQLREQIVETFKTQMKLRRKLMEIDSHLLSLGMESERQHMIISHWESRNNKLYKNSLNESRARTQQSMRRRTYTADGFRSAGYENDDTFDTDLDAEGESAIQQAWSELADIEREQERWSELRSHIEQKLEVCRQRGVTLEDQLPTLLSSDDEREILALMCRVHELEADKMALQSERLVRQHELRRRDLLILRYDRQRQICEEIITRQRQIMEDKKMILPQDLQELYQLYQQEIHASTYSDFGMPQTASAFTPTDILPPIGKIRLPTADLSSSDASGISPPSSADSGDSSIDRLMGQPVSRHSFSKKLPPLPPSPPVRSRKGSSSSMRRSLSEMHLSGSEDGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWQ4</accession>
    <name>A0ABM5JWQ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502368.1">
        <property type="nucleotide sequence ID" value="XM_050646411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502651.1">
        <property type="nucleotide sequence ID" value="XM_050646694.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646411.1">
        <property type="protein sequence ID" value="XP_050502368.1"/>
        <property type="gene ID" value="LOC126881824"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646694.1">
        <property type="protein sequence ID" value="XP_050502651.1"/>
        <property type="gene ID" value="LOC126881951"/>
    </dbReference>
    <dbReference type="GeneID" id="126881824"/>
    <dbReference type="GeneID" id="126881951"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="168" mass="19362" checksum="D99105C8A2AF9116" modified="2025-10-08" version="1">MAPTSGARAELRAVLSENSSLNVNFIDDRDDSVADKDHKPSGDDFPSQSSEDELQEPIPRLFKDKEVNSEKKKPTRWRQRNEEHYDRNERKRSRNSGQQYTSKKTKTIISSREIGEENSVLRKGRPAIIELSNIPKKYNEPLKIAKNKLDNIKSLFISRQCTTLFIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY91</accession>
    <name>A0ABM5JY91_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502906.1">
        <property type="nucleotide sequence ID" value="XM_050646949.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646949.1">
        <property type="protein sequence ID" value="XP_050502906.1"/>
        <property type="gene ID" value="LOC126882101"/>
    </dbReference>
    <dbReference type="GeneID" id="126882101"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13211">
        <property type="entry name" value="PH-GRAM_MTMR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF73">
        <property type="entry name" value="LD06050P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="563" mass="64368" checksum="44E04C9DC4CBBAF7" modified="2025-10-08" version="1">MDFIEMIKTPKLDGVILHSPFQDPVDGRICITGHHLIVSSMKEDVQELWLLHQCIDAVEKKVSSNNNAQSGGSILLKCKDFRILQLDIAHPEHFQNVYLSIHRLSNLEKPELLYPFFYRPMYTILEDGYTLFDLEVEFTKLIASDEWRVSNVNKNFSVCSTYGSTLVVPKAIDDETIVASAHFRDGGRFPCLSYRHENGTVLLRSSQPMLNNANRRCKADEKILNSVLGPYKKGYIIDMRSATYINYCKSKGGGTEPGGYYNQWKKVFKPLDKISKCDGSVLDHLAKFIEACNDPSSTSDKWISRSSNWMGHIQNTLNAACLVAQCLDKDGASVLVHGSNGQDSTLIVSSIAQVILNPDCRTVRGLQALIEREWIQAGHPFQTRHQKFCFTSSRSKGIQPTFLIFLDCIHQLHYQFPSSFEFKTDMLFLLFEHSYFSQFGTFLGNSELERSTIELSKNTTSLWSYLNRPDVLTSLLNPTYEPNKAPIWPSVAPVSIIVWADLYFRWIIDQQHQKITSTKVQNIIQRSKDLRSTAIKLRKQLLDKVKEFKCMQEELKEEEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYI5</accession>
    <name>A0ABM5JYI5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502995.1">
        <property type="nucleotide sequence ID" value="XM_050647038.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647038.1">
        <property type="protein sequence ID" value="XP_050502995.1"/>
        <property type="gene ID" value="LOC126882227"/>
    </dbReference>
    <dbReference type="GeneID" id="126882227"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="717" mass="79870" checksum="29C6051A1871135F" modified="2025-10-08" version="1">MWKMMDILNTHLQSNTSKDKSYISIKSPINIPLSPSFHQSLEISDGRESLGILPPNFDSEANFFNFTDRDSLNFKNILLEDSDPGRESLGILQINDLNVNFGNDTDTMPDIKLSFIDKVNQTHQILDTGFLITSPSKFLISATSPNSVLSFNSNSLEFPSKIFTLTRTDFSSSLFSPSKSLFNNAHIINSCDVEQRNRINSQPLPTKTTQAEVAFWSTRRPNYKKDSDILCYEQLKFDDDKDDMFQDSVFIEGNHIAQKLADGSFLNEHYEYGPLDSTPQPEWPTDMDDSESKKEENDHKVDTGTVFKTIDKLVPSVSQSKSEPNTKNSTSSSSSTRSREAKEMLQNLSDIFNTTHKSDKMKLEGRKLLSSLAEMLNNTQSSKDEEDSGHSSIIDNDSDKDKPDVSDGIKPNQISEHTQTVESTIKPEAAKTTSQLSQSSTLDKKEQNLERRNSSTSCVNLTTTNKSRTNSNSSVKSALSIGPSLGTKFKPKVGNPGLKTGPLRAVIPVKDMKKGTSTPDRIEQKTVQIQSKRTSTPIHEPRIKPMASSTPTLGNADSNSSPKWMANKPTLNRSNSLNDKLIKNGKDSSGTPNTSKLRRPSFSSSPVSSKEKTTTSSSVSSRFQEQYKITRRNSITEGLAPQFSQKRRNSLGKETGIMSSLRKVRENLLKSPYYDQKTGILVDGNNKIETDVEKKVTFKKSLNNSVKLKKSNKENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZJ9</accession>
    <name>A0ABM5JZJ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503367.1">
        <property type="nucleotide sequence ID" value="XM_050647410.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647410.1">
        <property type="protein sequence ID" value="XP_050503367.1"/>
        <property type="gene ID" value="LOC126882445"/>
    </dbReference>
    <dbReference type="GeneID" id="126882445"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="19936" checksum="BF2B1CDD515C89E1" modified="2025-10-08" version="1">MLTEERARAINFLAKADTWKIRFLLKKPSMSYVENIYLMTFTAEVWIATVSILFVFCLAIYFLMNWEKKELQNENQNISKKYTVSDASLLSFEALCQQGSELKSKTYAGKILLFLLFAALMFLYSAYSGYILVLLQSTTPIKSIRHLVDSRLEVGGINVSYQFPHYNDFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K146</accession>
    <name>A0ABM5K146_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050503912.1">
        <property type="nucleotide sequence ID" value="XM_050647955.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503913.1">
        <property type="nucleotide sequence ID" value="XM_050647956.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647955.1">
        <property type="protein sequence ID" value="XP_050503912.1"/>
        <property type="gene ID" value="LOC126882891"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647956.1">
        <property type="protein sequence ID" value="XP_050503913.1"/>
        <property type="gene ID" value="LOC126882891"/>
    </dbReference>
    <dbReference type="GeneID" id="126882891"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="18">
        <location>
            <begin position="4"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="19">
        <location>
            <begin position="838"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="17">
        <location>
            <begin position="1935"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="16">
        <location>
            <begin position="838"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="16">
        <location>
            <begin position="977"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="16">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="16">
        <location>
            <position position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2010" mass="225791" checksum="27F8015FA5EB1FF1" modified="2025-10-08" version="1">MADGEDIVISGVSGRFPECHNIDEFKEALLSNKVLLTEDERRFPRAYKDVPYTTGKVPDIEKFDATFFEIHSTQANFMDPRQRILMEVVYEAIIDAGYNPKELRGSNTGVFIAVAMLNSKALPKDANEYYYIVNNPYHTANRISFYFDFKGPSFAMDSACSGSLYAFSTAYQKLKAGEIDSAIVGGTNINFNAREAAELNQLGVLMKEGPCKIFGKDRAGFNRSEAVCAYLLQKKKNSRKIYATVLGAGANIDGYKSNGITHPSHEIQTTLIKDIYKKSNINPDDVAYFEMHATGTVVGDLVECESIADIFRGNRPKPLLVGSVKSNVGHAESASGVTSLAKLIIAMQSGIIPATINTEPADPKILAIGKDTFEMVKKNTEYKDGLMAASSFGICGANAHVVLKPSPLVKHVTKTDAKFDRLVQVSGRTENGINRILDEIERNADDDEFLSLLDEVFKQNVDGFEYRGYVVLGKDKQPLRESAQCTSTKRPIWFIFSGLGSQWTGMARDLMHIDVFKNTFNRCATAIEPYGVDLHKIIMDDTPNSLKDITNIFSSISAVTVALVDVLTSVGIKPDFIAGHSMGEIGCGYANGGLTPEQAVLLAYARGYATRQTTLPAGLMAAVGISLEKLQDILPKDIYIACINNSDGITISGPEKSIREFVDTLTQQGIFARIVETGNIAFHSPYLSDAPKHLLNFIKNLIKNPKKRAENWISTSVPSEKCNETWAQYDCAEYHVNNYQNTVHFNSIYQHIHKNAIVVEISPHGLLTSVMKRELRSENTLIRLMDRTAKDQTQHLLSAIGKIFMAGGQPDLKSLYPRPSFPLTRGTKFLSSIIEWDHTAKWDCPNPRKQDYFGTPVLVNLSDPKYSYLADHLIDGRSIMPAAGYLVLLWTVLADMQMMDITEIPVIFENIKLLRAVVLTEENNVEFVFNVMRKSGNFEIYEGGTVVVTGKIRTPTDVSSEFIYKDFDKIRHKSDAELELETTDVYKEFLMRRYHYRNLFKSILKCNLDGTAGKVSWNENFTSFIDCIMQLKILNFKDRYALNVPVSIKKLVIDPNIHYEDVKKNDNAVYVHHDQYCNIVRTKGIEVMGIKFSTAPRRKNIQQGEEFENIAFVKYISPENKKYNLDQSLAIALNIVLQNMFGFIKNVIVRELKTEDSKVPNEIQVKTELYYSKKVFVVSEYSSIKPNNIDSKIDLLILDYRMIEKYREYFRTLKEDAFILCIGNLENTKINEFEVIFQTASLSLLRLKQDPITYDEIIQIRENDYKWLETIKTVSKSITSKNVLLYSENDYMNGIVGLNYCLMSEDDIKVAFRSVLVNQIAPPFSIGNSYYTNQLSKNLAFNILQDNEWGTFVPIAAEPVKPRVVENAGLTIFKPGDLSTLGWTETRKSRSRIDEANIVDTCYFAVNYKDVMISSGRLKCDSQFIGIEYSGITKTGKRVMGLLFGGFKFQVKSDPMFTWTIPDSWTLKEAATVPVTYITCYLAMIVRGKMEQNRSILIHAGAGGVGISAINIALSLNSTIFVTVGSEKKKQFLRDLFPQLKGENIGNSRDTSFYNLVKQRTNGKGVDFVLNSLSGELFQMSVECLANEGSFLEIGKVDLLMGSSIDTGIYLDNCSFHGVMVDKLYNSTELKKQLHKLIQDGIDDGVVKPLPLKIFELEEIESAFRYLASGKNEGKVVVNMRKDGSSKPISVPAIPQIFFYPEKVYIIVGGLGGMGLELAHWLFSRGARIIILNGRRNIWSKYQKLSMNIWESLKYKAIIDLSDTTTMAGAENLLLEAQNYGPVGGIFNVALVLRDAPVYQQTTQMFEDVCRPKISSSKNMDVLTRKMCPQLDHFVMFSSVVASRGVMGQTNYGYANSALERLCERRKRDKLPGLAIEWGPVADVGVLVTEKFNTKSFGNLLHQKPESCWKALEQFMILGAATCMSCVYKNNQEEAKKEKTPIDIVANILGIANIDTVDKHKPFNNFGVDSLMASEIKQILYQEFNKVIEVEDVRKLNFEKLSEFLDSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3G7</accession>
    <name>A0ABM5K3G7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Venom serine protease-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_050648773.1"/>
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</entry>
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        <source>
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</entry>
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            <taxon>Chrysomelidae</taxon>
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                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        </source>
    </evidence>
    <sequence length="675" mass="80390" checksum="772DD11F0FE352E7" modified="2025-10-08" version="1">MEIMEAPNGPSSHEENDTNPRAEGKTVNKNIKVVDKHLRTHMGKKPHKCEICFKQFSTASYLKVHLRVHTGERPYKCEICFKQFVRADQLKVHVRKHTGEKPFKCEICFKEVSTASYLKVHLRVHTRERPYKCEICFKQYITASQLKVHLRVHTGERPYKCETCFKQFVRAEQLKVHVRKHTGEKPFKCEICFKQFTDRAYLRQHLRAHTEEKLHKCGICFKQFTTARYLKVHLRVHTGERPYKCEICFKQFVRADLLKVHVRKHTGEKPFKCEICFKEVSTASYLKVHLRVHTGERPYKCEICFKQFTHYANLKHHLGAHTREKLHKCGICFKQFTTALYLKAHVRRHTGEKSFKCEICFKQFSTASYLKVHLREHTEEKPHKCGICFKQFTRARYLKTHVIMHNEEKPFKCEICFKQFSIASYLKEHLRIHTGEKPFKCEICFKQFANRANLRQHLRAHTEEKLHNCGICLKQFTTARYLKAHVRRRHTGKKPLKCEICFKQFSTAHYLKTHVRRHTGENPFKCEICFKHVSTASYLKVHLRVHTGERPYKCEICFKQFTDRAYLRQHLRAHTEEKLHKCGICFKQFTTARCLKTHVRRHTGEKPHNGKRVHTGKTPYKCEICFKQFSQTSTLKNHSKIHAKEKLYECEICLEEFRERRNLKTHLQVHSKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5I1</accession>
    <name>A0ABM5K5I1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505443.1">
        <property type="nucleotide sequence ID" value="XM_050649486.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649486.1">
        <property type="protein sequence ID" value="XP_050505443.1"/>
        <property type="gene ID" value="LOC126883816"/>
    </dbReference>
    <dbReference type="GeneID" id="126883816"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23303" checksum="DF397BAF3081B120" modified="2025-10-08" version="1">MTNDDTCGSGNNNFLETQLPKKAMDKGTSSSSSDSSSSSNSSSSSKSSSSSNTSSDTDNSSQHSKTDTDPYGSDDSIADPPFNPPVIKRQVKITTGNAIKKRKVKDPSNNEKVGRKKLRQPATWKQEDTKRLRNGGEAYLSTRIVQNADGTKTKSKILRPAKTLLPPCGNKCKLKCSEKLDEAQRNKIFKEYWNLNDLDKQREYIVDWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6A3</accession>
    <name>A0ABM5K6A3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TGF-beta propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505722.1">
        <property type="nucleotide sequence ID" value="XM_050649765.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649765.1">
        <property type="protein sequence ID" value="XP_050505722.1"/>
        <property type="gene ID" value="LOC114332327"/>
    </dbReference>
    <dbReference type="GeneID" id="114332327"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047321038" description="TGF-beta propeptide domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta propeptide" evidence="3">
        <location>
            <begin position="161"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="471" mass="54217" checksum="32B19A118ADD5EBC" modified="2025-10-08" version="1">MCRCVWTLFFLSLVGLGSSAPGFRKGMSEEAETSLNKFLKVYLDEVENDGVSDDDLYGKMLGDQPQDENTIHHTGSSTTGESRNITSVEYSRAMRNRNRPNDPDERSRENRIQELKDTILKYIGRKPEDELPNVSVNVTKDLPKFWNLPNISSNDQVTEKIRSFYPSCEIPANTDQDLWKDDDMMNLFFNFDIFSETKNSNIATATLRLYRLPENNTKTNNKPDCESFNSAEEEKLLRVSIYWYTKSLKKRRVKKRLSDSKVISETAQWIDLSVKPATKAWSRGRNLGLGVLVEDQEGNNLRANRIFKGTSCTVGFSTPKPIPTLIVDAARQTNELDRIHSLLGRNSTSALHSDIHMLPTLDICTLEFPENYTFSAKSRINACNLKKIYEQSQFMAEKEKMERLASLPDLVRPQSQQRHIRHQRQHMSNKQTEDLDTHDIRSRIMGQKIVLRHEELQNLTHNNPNLSVINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6A8</accession>
    <name>A0ABM5K6A8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Patronin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505727.1">
        <property type="nucleotide sequence ID" value="XM_050649770.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649770.1">
        <property type="protein sequence ID" value="XP_050505727.1"/>
        <property type="gene ID" value="LOC114332661"/>
    </dbReference>
    <dbReference type="GeneID" id="114332661"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF0">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="210"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="10">
        <location>
            <begin position="1594"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1451"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1526"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="697"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="828"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1384"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1735" mass="197355" checksum="82A3C210FF2B3204" modified="2025-10-08" version="1">MWSAISKIFTKNFSTNNVQDEEDLSDEMDRGAKRKTDMDITFVTRLAKQKASIKWLLSKAFNNKIPENLKEPFYRDHENQEHLKPQIVGGLANAEIYCLALGNIYSDPNYHNLNHWAILQTLSRKSVYHNEDAQLTETTLIQTNPLRMSAHMAVIEMIMNLYTKEVVSADRVLSAIYRFNHGKGPAPNIPDNVVDQLLQWVTHACDAMRMRIEEEIGEEQNGGDGDRLKVPEFSPLRDLKDLCDGVALAALISYYCPDELSWTDIRISRVPSVQDSIYNLQLLQDFCSRCLPSSIFHLMPEDITYMRETMKQNLLVFLADLFNVMEINPAKCVRYPGMEKISSEGLPTINLHGVTHKRNLLQTVMAPIPDLRSGIDEPADPTAFQVQRATPTHQTLKKANSLQHSVSDMTEDSLRLGSEDSFVVHKSKNIPTLRSIVQEEPLVPARLKANKEKQNNTSKADERGEVAAGRPSNWEENRKSTYAGRRSRRNSTSEDSQLTIENFGGSQDNLNFIGKNPSKEVAVHIGRKISAPAFPTPIDNPPVRSLYQDTKGSIQLGYENGCDEKQDNGSEKYKLKRQLSSDDIAFRNISSNINKETIIRDLVDGEITKRMSFAELGKQKIVGENRGIQLVYMNDKEEYPHKSSFLSKLSNNNTSEKKAKFATLPNTTTWQQQSTQNQQISDSNGEEQSSNVMAVQLNDIRLKLEEKRRHIESEKRRMEVAMNKQRQKVGKAAFLQAVAKGRGNLLKSCDTESNNSAESSEIQSPSSESSSPTPNPPRPLQEINEDTSKSERPWPEEVQTLAETRTPDLENVDLDHYQQSIAQMNSSLHDIQSDMQRLASQQNQLQQQNIIAQQQKQIQALQQQHQYQSVQSQQHTPQHSSHQPYHSQMYEAPQVYAPALQMSASAPHIPQTLYGQHRVGQEQFFLHDQSESPSPQIPTQRRTWAQQPQPPPIPIESYHQPELRTWNKSTSQGETKGFIVHDTDRYQDQPRYQEEPRYQESARYFESPRFFDNKYQNGGGGGDKEHILHNSNSFTLSQQHHHSNYGTSHSTPSASPQHRNIHRQISQLLDEGKRTPVSLQHMDSKEPPQRKTSITHAPIPAPSADDMEPQNISFIGNSTPTKLSEGLSRLNITSGSRTYRIPSPTRPSITRNSFQPTPSPPVIDSIPLAEISNLDNDALNQKGFYISFDDQPKRPKPPLRTKRMSPKKERSFVQSSENVYDKKMEIEKQEKQKQLERQLEQERIKNIQEELREQEREKLRINQEASQERQRVNAASAIIIENDVNKNDPDLDYERERKKEKIMLLSLQRRQQQEEAKARKEAEALARREMEKLKEEEKVRKKEEQAARRQAILEQYKLKKALEEAEREGKTLDRSELNSLKPTPKMRPKASTRPRPKTIHIDSGSVQMAEGMSSRGKKGSSSNLTAYSSSTMKRDYYRGSQDSLADRSISSGMLYKDSPDDSRGVSPCHSANQTLGRRSSYKTSRDPSPAQIRGRPKYSAYQNFKGRKSSSMMNLYGSSTDQDSLAYRYGDTDSGLGRATPPRRAPSPGISMRHLPSPSGPGSLPGFMTKGRRMFDDGSSDISSTPSSMMDYNGPRLYKQPATKSNRSIMLNAVEYCVFPGAVNREAKKRVLEEINRSESKHFLILFRDAGCQFRALYSFCPEREEITKLYGTGPKQVNDKMFDKFFKYNSGGKCFSQVHTKHLTVTIDAFTIHNSLWQGKKVNLPNKKDMALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6E4</accession>
    <name>A0ABM5K6E4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505763.1">
        <property type="nucleotide sequence ID" value="XM_050649806.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649806.1">
        <property type="protein sequence ID" value="XP_050505763.1"/>
        <property type="gene ID" value="LOC126884023"/>
    </dbReference>
    <dbReference type="GeneID" id="126884023"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="150042" checksum="7CAB50DCE67D3E44" modified="2025-10-08" version="1">MIKEIVKQSDNLLLTIKRLRKIIFDKFTQNDAKVWLKRLNAHICKCNNLIKAKNLPVGTARKLQSNVGHFKHFRRIILNFNRHVGLGLNSKLRNRVKWENVASSFASRIKTGVIINLCHKDVGPFLDDAFTVFRQKVKTLLKSNRVLKVNTTLWGEFIKKTGDSESLDLMHFSTKNVIINSYSTDLHIWFSENVKDKIFKKMSEFAEKDSGAALSKVISLEVNINKVKIGNGSSYIKLPEQIQKRRACINIKNYDQNCFYWAIISSFYPAKIHTERTSAYPYYSTALKTEDLEAPMPLSHITKFEKINTISVNVYALELNQVKEKQFYDVVPARLTQNKLDRHVNLLLIQDKYFPKLNDYDAPPSDDDNIEIKYHYCWIKDMSRLLSSQLSKNTNKKYICDRCMNYFSSGNKLAEHEEFCRDINKCKMTVPKYDDVAFRNFTYKQTTPFIIYADFECQLHNFTDSNVNLNKTTKYQKHVPYSAGYYLKCAYDDSLSYFRSYRGENCMEWFAKEMAEISKFVDSKIKSIVPMVKKPSTSKATACHICEKRFLATDIIVVDHDHFTGEVRGFAHQACNLNFRKVFVVPVAFHNFSGYDSHFMIIDLCKHGHLSLLPINKEKYISFTLHSDEHKIRLRFIDTMRFMGASLDELASLLDTSEKKILKQEFNSLDDDAFNLLTCKGVFCYDYVDSLEKLEETSLPTISHFYNKLCDEHISEQKYAHAQKVWSTFECKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYHLDPAWYYTIPGYTWDCMLRYTKCRLELLKDVDMILFIEKGIRGGISVCSNRFSEANNKYMSTYDPTQPSKYIMYLDVNNLYGWAMSEYLPFGGFKWIEDVTKFGVASKSTKLPKGHINIMSIPNAAKEGYFFQVDLEYPRELHDKHKDFPFAAEHRIPPGSKLPKLLPTLFNKSKYIIHYRNLKQALSNGLILTKIHKVLKFNQSAWLRPYIELNTNLRAASKSSFEKNLYKMMNNAVFGKTMENIRRHRTGKICKNWNGRYGAKNLIASIRFHSRTIFSENLVAIELTKSVVCFNKPLYIGAAILDISKLCMYDFHYSFMLPTMGEENCMLLYMDTDSFIYELQCLDAYKEVLKAHNSKFDTSDYSENNPYMIERLNKKIPGLMKDEANGKIITHFIGLRSKMYTFKLQTTDEEREKERERLKLKLNKEQIDCGIQNLGITKKAKGVKYNVVKNIITFEDFENCLKEYKIKSTNQRCIRSYQHSVFSIEQTKTALSPYDDKRYLIPESFKTLPWGHCDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7T5</accession>
    <name>A0ABM5K7T5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506243.1">
        <property type="nucleotide sequence ID" value="XM_050650286.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650286.1">
        <property type="protein sequence ID" value="XP_050506243.1"/>
        <property type="gene ID" value="LOC126884354"/>
    </dbReference>
    <dbReference type="GeneID" id="126884354"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="157"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="305" mass="34772" checksum="66CFD9E29C6966CA" modified="2025-10-08" version="1">MDLSSSSSSSSSSDDLEDIMHMLPNIRSVRDRNDLYNKYNEDEFKERYRLSKKTVLILLERFHEHLGYRTERNNPVSPLTQILITLRYYATGCFQQVIGDLVEIHKSTVCRIVHRVGHHIALLREEYITMPKNPRDVTMAKQGFYAVANFPGVIGAIDCTHIRINSPGGENSELYRNRKGWFSMNVQIVCDSKLCIMDVVARWPGSVHDSTIYNSSLLRAQFEAGEYPNCYLLGDSGYTCTNFLLTPLSQTNSEAEERYQNAHIKTRNVIERLNGVLKRRFPVLATGMQIDLNNVGRVIVATSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8L9</accession>
    <name>A0ABM5K8L9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506529.1">
        <property type="nucleotide sequence ID" value="XM_050650572.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506530.1">
        <property type="nucleotide sequence ID" value="XM_050650573.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650572.1">
        <property type="protein sequence ID" value="XP_050506529.1"/>
        <property type="gene ID" value="LOC114336806"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650573.1">
        <property type="protein sequence ID" value="XP_050506530.1"/>
        <property type="gene ID" value="LOC114336806"/>
    </dbReference>
    <dbReference type="GeneID" id="114336806"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="340" mass="39764" checksum="AF0A6C72272FB523" modified="2025-10-08" version="1">MSENSKAQITQLFTSFDSFVKILEDSEWFPTAKIEDIKTAFKLGNYIEKTTHHFKSNDLWNNFSATLISWWKTKNRTKVYCDSVYSFACDELLIRFFRCSNISHNTLDIAVTIYTSLLPKTRFESLLERLILDAGNLEAVTDYLNSTTNDGNAKHLEYQLKLRYWDMLLQLGQESALKEQIKDMLLPYNVETFLYILIGILSLDELSETEKQVQNIILNDIINKMFDRSLLGKQFWLTLFKKIDKTCTYTVCKNFNTFLSNFLNFIIYVGSMMKKVGNFWKSDPNICFYPEIEYADILAHIINLNEIDSIRLTLKDRLKDAKESTKSDIWDQILSDISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9S0</accession>
    <name>A0ABM5K9S0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506934.1">
        <property type="nucleotide sequence ID" value="XM_050650977.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650977.1">
        <property type="protein sequence ID" value="XP_050506934.1"/>
        <property type="gene ID" value="LOC126884759"/>
    </dbReference>
    <dbReference type="GeneID" id="126884759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="185" mass="21715" checksum="BAA110217DE4AB6A" modified="2025-10-08" version="1">MDNISEQLKLMAENKVEQERRAKLITQLSGKKYDLQKSLKETESEIDLKQCELEKVKKEVITLSCELPLWQEKEKVARECFRDLVRQVVEMDDKVTSVQTDLWTSINEWITSSSQQLKKNVLAGNSTKSNSPELEERIKHERIEQIKLEGQLEAVKAYEKFLYRKVDEILRIKDIIDDVDNRCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF80</accession>
    <name>A0ABM5KF80_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508857.1">
        <property type="nucleotide sequence ID" value="XM_050652900.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652900.1">
        <property type="protein sequence ID" value="XP_050508857.1"/>
        <property type="gene ID" value="LOC114326165"/>
    </dbReference>
    <dbReference type="GeneID" id="114326165"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15302">
        <property type="entry name" value="7tmA_mAChR_GAR-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="142"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="814" mass="91078" checksum="1050F147931A697C" modified="2025-10-08" version="1">MPPLVMVAIPESLWSINHRTLLLLQFKLRLSVDSIKGQKRQKQREKFCKTVYSGFLTLTECYESFNLSQNIPWDTEDPLNIFDSSDWIGSGYRLLNSTAETNRSGEDNLDNTLTPVLAPFKLWQTILIAISLGICIILTVSGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTVYVLMGYWNLGPLLCDLWLSVDYTVCLVSQYTVLLITIDRFCSVKIAAKYRSWRTKQRVIWMVTITWIIPALLFFISIFGWEHFTGYRDLQPGECAVQFLKEPVFNTALIICYYWTTLIVLFILYGGIYKTAFDMQKKSEAKQRKMQSMVALSAGAMSGMAGRAAGIGLSKAQSNSESQDKPLPVQNASVVNEKQPDKNTLTIEEDKSFXTSLSDSATTTTTTTTTATSCDRKSLCPPVGKPAQDAGDKSERSSSPAFESDEDSTAPVQEKDKEKEKERERDREKEKDRDKDKMLANKKRTSVVGMIMHSSAPLHVFTNTRVNGDLSPQRPVLERPTLLQITERDPLVDSKKSKTYTVGVKPPPPDHPAAIVNSKSYDSTLQPHVDSKKPSNSLIYKTHSTYDLLLGLDSADLRYMDESSVVVPSPTLENPPPPLSNTSSPRVVQGEQKLQTEVTISADRPITSVVNEEDRVGETEDSSPLGGISAISQTGKNGPFNTSCNNKPRFCTESVDNPKRVFVKSIGKRLKAKKKTLGPLGFGRQKSKSENRARKALRTISFILGAFVVCWTPYHIFALVEGFCTDPPCINSHIYMFSYFLCYANSPLNPFCYALANQQFKKTFTRILKGDFHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFW6</accession>
    <name>A0ABM5KFW6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger BED domain-containing protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509092.1">
        <property type="nucleotide sequence ID" value="XM_050653135.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653135.1">
        <property type="protein sequence ID" value="XP_050509092.1"/>
        <property type="gene ID" value="LOC126886266"/>
    </dbReference>
    <dbReference type="GeneID" id="126886266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21141" checksum="F813BBFC20C4CC4F" modified="2025-10-08" version="1">MDDIMKITTKILNSIRARSLQRRFFKSQLEASDSAEHTALLLHTDVRWLSRGKFLDRFQELLPEIISFLEELGDDTHLLQNEKWLSDLAFLSDLTNHLNVLNLELQAPAHYNALVNGELDELFPERWIGRDGPVHWPPRSPELNKVDFFFWCYIKDVVYRTSPTTADDVKIRIKDAFQSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJB9</accession>
    <name>A0ABM5KJB9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 71-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510306.1">
        <property type="nucleotide sequence ID" value="XM_050654349.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654349.1">
        <property type="protein sequence ID" value="XP_050510306.1"/>
        <property type="gene ID" value="LOC114333625"/>
    </dbReference>
    <dbReference type="GeneID" id="114333625"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053040">
        <property type="entry name" value="LRR-containing_protein_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46984:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51626" checksum="82E1535A127BBD62" modified="2025-10-08" version="1">MAAVTGNLARKLSNVGGKSRSSLKNIYGDGGETIITKLNKNRAKYEFKKKPLACAYAEGKSYPKCELRESETSVYFEFKNLRKDLPVVDENLISIVFKNDSLESNLLLLLKDCLQDGHPLLTVIKFEFCNLQAKHIEQIAELLTVFFINVKEVSVNGNPIPEQNFYLLLKQELTSLSLKYCSINIDGMKQISEELYKPYVNPLLHLNLATNALYDESLYYVARILRMNRKLKSLNLADNKITERGIRLLLEPLQKFELNEDELIERRKIRFEYHKKMIDVYCATKSDQSDLSITCSARKIRSRRRNKFFERRIHHKVGHRPSVPSYEQENNLTSRTSIPELPHHPALQDSVEESTSIFCYGNNILTNLNLSYNKIRQEALPLILQMISYQNDLYSGKPEPAHIGITRLSLQGNRLSETDIIEVETALSRKYQLTTGSIDTMTVLQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKF8</accession>
    <name>A0ABM5KKF8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510687.1">
        <property type="nucleotide sequence ID" value="XM_050654730.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654730.1">
        <property type="protein sequence ID" value="XP_050510687.1"/>
        <property type="gene ID" value="LOC126887303"/>
    </dbReference>
    <dbReference type="GeneID" id="126887303"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045979614" evidence="1">
        <location>
            <begin position="17"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="43415" checksum="57EDA918090E9B46" modified="2025-10-08" version="1">MTKLTLFFCAIILASAYSYPKNVSDDSDDCIDTIKAIVYITEIFIDLFLKAAPQLIDEIKDIWSDFEVLEVDIASSVYDVIFELVNDKLRTWSENTTDAGKKLANCLIDANDAAAAVPMDFINHTLVCSGDDFIALVKSLPALIEDLTDVQVDAKRAADKINDCDGHDYNTALCVLDVNSFHTQLLIPEYDNLIDTIKELIHNVEKTLDRSIEDVTKAISEIDHNYTGSQNKIVNAWAKIINGIFKKLTNVLDRIAEDSTALGKKLAKCFEDSNINLVPVLFVNLTLSCIEDDVIKVAESLGPLVKQLAEVQKKAKAATENIDECGDNITDIGCVLKVAVDLVRIAGEIPAIIESALAPIEGAIENLIKIFQTCAKDNNHPNAAKILGQIGNCVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKG2</accession>
    <name>A0ABM5KKG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of G-protein signaling loco</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510623.1">
        <property type="nucleotide sequence ID" value="XM_050654666.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654666.1">
        <property type="protein sequence ID" value="XP_050510623.1"/>
        <property type="gene ID" value="LOC126887252"/>
    </dbReference>
    <dbReference type="GeneID" id="126887252"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06710">
        <property type="entry name" value="PDZ_RGS12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01817">
        <property type="entry name" value="RBD1_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17067">
        <property type="entry name" value="RBD2_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="662"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="5">
        <location>
            <begin position="893"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="RBD" evidence="5">
        <location>
            <begin position="964"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="149866" checksum="2F60C254AC8615A1" modified="2025-10-08" version="1">MHPNRRRKKRPNYGIKTVEVMRGPNGFGFTISGQQPCILSCIVANSPADQAGLRAGDFLISVNGTSVSKITHDAVVSLIGNCIGPIKMTIAENYFSDSSDEELECSRMVTTRKPKYTHKPRVRKEVNRVELKNVSKQMTANLPDRAGCNYTAPVPERHFNIPMEDEAGPIEYKALVGYLGTIEMPKQLLPNSRLQTVCSCIRKLRQEKRAPTAILMTILPTCLTLKNSANQILAIYPTSRVVYVGSTADKESRYFGLVTTAVSETRFHDNNDNAWNSADKKNINESIEISNSCHVFVIDPKIIDHTAHQSRAENFKITCTRNTVNGYCMEFPGSALYVVSLIQNMYKLQNGDKAGENFGPLVANSPQPSASSNSDSGIGFRDDCGNISDRILVVEFPQHRPFPLQSNVNRPLGIDAANLPLEGLDMPFENSQQNVFSRAEPQCVDNKLLNNLNNIRACETKPESNSIIENIKPKVCVKVSDSSDDNTQRIEEGFRERAIDCPDSPQKLSVKEFATNLDSKSGSFDDISMHSSKSNELSNLLSIFKVPFETKKHKKHLKVSSCDNLDKCNRNLIHHKLSPKVYGLKPNYSCEELNNLENNFDVGDKLGYGSLQDLSYHEHRKVQKNILSDPDVRIEQQEEESCDDQNFVKCNYSEGPSVWAGSFEKLLADPLGLHMFAEFLKKEFSAENIYFWIACERFKVLTSENDRRNEAQRIYRQHLCGGAAEAVNVDAQARQSVERNLHSADLDLFAQAQKQIFNLMKFDSYPRFLRSDIYRKCLSGEEDKIQIDVRLILQPISTPTKLKKSVSNAEDRRRKSLLPWHRKNRSKSKDRGESEYNKRGSDPSSGDLKNIDPSEVHSSGSSLTSLDIAVSSQDLIKAQASQEELSSNVARTALCRVLLSNGSTTVVQIKQSETIQGLVTRLLEKRGLKYSSFEVFADKHLKCVNVEESSMTLAGCEVTVEQRVVFKLDLPNRKMISIRSKYTKIITDVLRPSLHKYQYNLDQMVVLNGNTPIDLHQPVTTIDGFRLKVQYKEDFRQENPNVPIKNNKVKLEEITNKVYEGILQEKCESLSCKLTKSDRGSVKSEDWGSEHSSTFIGKFLRRDSGIHERKKKIPTRFKEETMSDQSQMKKPLIAKLKCGANKFNLVPSSESDELVEGLTRAQRRIEDQRGTEINSELPDFLKDKENEHLQKQRRSDLEGSTAKFYLGETSVPASSDKLPVISSAKNMKLELQSNYENRNVLVGSKYQDSRYDIKSSPSKSEGVQSTTSPVKSTITSVDRMEPPPLPPKPKVMPIKPPNWGQVNGFYKSKDIPSTDRKQAMFLEQSSSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL97</accession>
    <name>A0ABM5KL97_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510974.1">
        <property type="nucleotide sequence ID" value="XM_050655017.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655017.1">
        <property type="protein sequence ID" value="XP_050510974.1"/>
        <property type="gene ID" value="LOC126887469"/>
    </dbReference>
    <dbReference type="GeneID" id="126887469"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047514024" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="149" mass="14517" checksum="492848116799F2F3" modified="2025-10-08" version="1">MDFKLAVITVFSLVSISQASIIPTVEVLQGPGSKTLLIGPDGSAIDSAAPGGTVVTNDHGSGLVAAGPAILPLGPEIVVNSPAGSIITSHSLAGPAVVPGVVPALAPSAGAVISAAISVEGPAAQNVEGAYVPDNTEALYDDGSYKGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRZ1</accession>
    <name>A0ABM5KRZ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512962.1">
        <property type="nucleotide sequence ID" value="XM_050657005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657005.1">
        <property type="protein sequence ID" value="XP_050512962.1"/>
        <property type="gene ID" value="LOC126888646"/>
    </dbReference>
    <dbReference type="GeneID" id="126888646"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="213" mass="23885" checksum="22076E53D82B3506" modified="2025-10-08" version="1">MTDVKIPPFWPNDPEIWFLQVENQFTLANITSDATKFNYTVANLDTAYILEVRDIIVSPPATERYAKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAVLADTISEAIAPRAQISEASNALESTIEKLTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRRRPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS58</accession>
    <name>A0ABM5KS58_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513019.1">
        <property type="nucleotide sequence ID" value="XM_050657062.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657062.1">
        <property type="protein sequence ID" value="XP_050513019.1"/>
        <property type="gene ID" value="LOC126888692"/>
    </dbReference>
    <dbReference type="GeneID" id="126888692"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="117" mass="13059" checksum="A858C2A86E8EBA62" modified="2025-10-08" version="1">MRSRLFYPYSLALGAACGLLILTVLMIYAFLRRNRGKCNDEEKQNSSSILVYPTKQSGSPPQFLTKEIHFSLPPLRSNSLGDIVLSSEETPYETELGTDSLLLPSVGHNFRSNSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUB5</accession>
    <name>A0ABM5KUB5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513778.1">
        <property type="nucleotide sequence ID" value="XM_050657821.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657821.1">
        <property type="protein sequence ID" value="XP_050513778.1"/>
        <property type="gene ID" value="LOC126889484"/>
    </dbReference>
    <dbReference type="GeneID" id="126889484"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238:SF8">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46238">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="225" mass="26351" checksum="18F45FD2DD5A0927" modified="2025-10-08" version="1">MYADDVVLIGNSERDLEQKLEQWRQALEEKCLKLSRTKTEYLECSFKDGATTNKMVSLDGEMIVKSNSFKYLGSVLQSNGEIDGDACSRIRAGWMKWKEASGVLCDRKIPMKLKGKFYKTAIRPAMMYGTECWAVKKKEEQRMHVAEMRMLRWMSGVTKKDKIRNEYIRESLGVAPIDAKMREHRLRWFGHVQRRDVNRPIRRIAEVQILGRSSRGRPKKTWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUU2</accession>
    <name>A0ABM5KUU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513953.1">
        <property type="nucleotide sequence ID" value="XM_050657996.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657996.1">
        <property type="protein sequence ID" value="XP_050513953.1"/>
        <property type="gene ID" value="LOC126889588"/>
    </dbReference>
    <dbReference type="GeneID" id="126889588"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="220" mass="25216" checksum="0E7CDE5854D158A7" modified="2025-10-08" version="1">MQATRSHRILSMVLNRKENNNQQPSSSTKQVSETAVFTEFSEVYKVSATDGTLIPIEGDFRDTTDWHDTENISILLSNVQQQIFQDEVLGEVAHEHLVETDERTENINSSPAYLEQRKTQQQIFQDEVLCKDTHEHLVETDKVTENTNPDTYLKQTHLLEIGNLHLNPGSSITSEESNQNYDYILEEDPDFSDKTANNEEKTDCARSSDEDSNQNDDDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVR6</accession>
    <name>A0ABM5KVR6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxylate reductase/hydroxypyruvate reductase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514281.1">
        <property type="nucleotide sequence ID" value="XM_050658324.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658324.1">
        <property type="protein sequence ID" value="XP_050514281.1"/>
        <property type="gene ID" value="LOC126889752"/>
    </dbReference>
    <dbReference type="GeneID" id="126889752"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF119">
        <property type="entry name" value="FI03731P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="120"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36131" checksum="EF851C8ADDD4318E" modified="2025-10-08" version="1">MSMVEVNMDDQKQRPKVLITNTGVCEEAIDLLRKYCDVVVNETPTRDAILSKVKGVDAIFVKKPVIIDKEVLDAAGSQLKVVSLVSRGIDSCDTDELKRRNIKLTHLHDENATAVANSAIMLLLAASRRYHECRLAIEQNAWERENRQWMMGYGLQKATVGIIGLGNIGQAILKRLIHFDVKRFLYTGPKEKKEGKELCAEFVSLNTLLEESDFVIMGCPLNNETNGMCNAEFFSKMKKKAVFVNVSRSGLVDQPALIQALKSGDIFAAGLDVMTPEPLPVDHELLKLPNIVLTPHVAFKTRDTMKHMGNSTALRLLRALNVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KW14</accession>
    <name>A0ABM5KW14_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514380.1">
        <property type="nucleotide sequence ID" value="XM_050658423.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658423.1">
        <property type="protein sequence ID" value="XP_050514380.1"/>
        <property type="gene ID" value="LOC114334467"/>
    </dbReference>
    <dbReference type="GeneID" id="114334467"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047082126" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="5">
        <location>
            <begin position="150"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="415" mass="46317" checksum="11700AD1745A99D4" modified="2025-10-08" version="1">MNSVIIILVGYLLSVGTCATTGCEINPFGSKTPLVVKYGTSSLIEPTPGYTTLSFTRNAAVEFACPGTQIIKNGTSLGDIVTATCKTGDVFNINGHTVHWSYLSCNNVINPTVREITRATDTNDPNNKCVDNVKKLQIIQIGFALSSDRFSEAMTVCFDSTTRLAIYTYFVLSKSINYRARNVANPSFSQDDIFYRMGRSVNAMYQSIQTTYNTLVGLEATSTQYVNTSIFPNRGHLAAKADFVYEPHQRASYRYVNAAPQWNTFNGGNWNQVETDVRNYANNKNVDLKVWTGVYGISSLPNSQTSELVDLYIYVNHQDKKHSPALPAPEVFWRLVYEPITQHCIVLVGHNNPYEEITSNSQKICKTDVAAKVTWLKWNKNNVRTGYSYACSCTDSKFKTLITVLPHLTIKGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXS5</accession>
    <name>A0ABM5KXS5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514985.1">
        <property type="nucleotide sequence ID" value="XM_050659028.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659028.1">
        <property type="protein sequence ID" value="XP_050514985.1"/>
        <property type="gene ID" value="LOC126890175"/>
    </dbReference>
    <dbReference type="GeneID" id="126890175"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21079">
        <property type="entry name" value="DHD_Ski_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="2">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="293" mass="33072" checksum="D14D1414BDD68F73" modified="2025-10-08" version="1">MEVTPHLKSVLKNYQHSATKSLQGPGLSLVTVKHEIPSPEISEEEFVPAPFPVQQVPILTIPDTSCSERTETILEGESISCFVVGGEKRLCLPQVLNSVLRDFSLQQINQECDQLQIYCSRCTPEQLNVLKNQGILPSGAPSCGLITKTDAERLCSALLYGQVTTELRPRKGSLSIPIYHECFGRASGLCYPELYTNKNAKCIECGDCQAGFSPQQFVCHVHRNLENRTVHWGFDSSNWRSYLHVPKEHIEEHYEQFVKILDEMWQRYEGSIGFPPPVVEPIIKRKQDSLLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXV6</accession>
    <name>A0ABM5KXV6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515028.1">
        <property type="nucleotide sequence ID" value="XM_050659071.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659071.1">
        <property type="protein sequence ID" value="XP_050515028.1"/>
        <property type="gene ID" value="LOC126890217"/>
    </dbReference>
    <dbReference type="GeneID" id="126890217"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="46626" checksum="DE4ECF3F82AFBA64" modified="2025-10-08" version="1">MDAAAGTSTTQSHRHKPLSKAEKQIVWKVYDGLKKTHPTTEAVDRCSFLTGVSATTVERIVRELKSTETLSAPKTRQRGRRSFHLSESQMSIIRRTVHTFFLENKLPTIKSVKVKLQENDMIPQMGRETLRKVLHKKIYYLDETWINAGHTVSKIWHDTTIRTPRQAFIEGLSTGLRAPSGKGQRLIVAHIGSDTGFLENNALVFISKKTGDYHEDMDAVCFERWFENVLQHLEPNSVVVLDNAPYHSRLVERIPTMSDKKAVLQHWLREKSIPYGEDMVKLELIGIIKQHRGTYRQHAVDTMARLHGITILRLPPYHCELNPIELIWAQMKGYVARENVTYKISDVQRLLQASLDSINSTDWKNAISHVIKVEDDMWRLDGMVDNVIEPVIIQLGSNDSDSSAESME</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXY0</accession>
    <name>A0ABM5KXY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515051.1">
        <property type="nucleotide sequence ID" value="XM_050659094.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659094.1">
        <property type="protein sequence ID" value="XP_050515051.1"/>
        <property type="gene ID" value="LOC114331158"/>
    </dbReference>
    <dbReference type="GeneID" id="114331158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="232" mass="26371" checksum="B47A58047CB7AE53" modified="2025-10-08" version="1">MGQAKSQFTDDELQNYQDLTYFTKKEVLHAHQKFKALAPEKVGHNKNAKLPMEKILLYPELSVNPFGERICKVFSSNHDGHCTFEDFLDMMSVFSETAPKSVKAEHAFRIFDFDGDDMLGKSDLQEVIRTLTGEYKLTDAEIDTLIENILEEADFDDDRSLSFAEFEHITDKSSDFLSAPSTPGRPFIYHHIMDENLPTQNIRELLLSSELPCSFSQTGSVFNPIGDDSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY54</accession>
    <name>A0ABM5KY54_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515115.1">
        <property type="nucleotide sequence ID" value="XM_050659158.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659158.1">
        <property type="protein sequence ID" value="XP_050515115.1"/>
        <property type="gene ID" value="LOC126890300"/>
    </dbReference>
    <dbReference type="GeneID" id="126890300"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="166" mass="18692" checksum="F0B0D56BBBC25312" modified="2025-10-08" version="1">MSADQFNELLRTVAASPGTNNSSGSFSKCTARFSGKRCHNTVETFITTVSIYKEIEKISEADALKGLPLLLTDNAAIWWQGVQNEAKTWNDATQLLRTAFSPSKPAHQVYVDIFNNKQQSNETIDEFVTQKRALLAQLPLNRHDEQTQLDLIWIAESPHTERSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY57</accession>
    <name>A0ABM5KY57_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515124.1">
        <property type="nucleotide sequence ID" value="XM_050659167.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659167.1">
        <property type="protein sequence ID" value="XP_050515124.1"/>
        <property type="gene ID" value="LOC126890308"/>
    </dbReference>
    <dbReference type="GeneID" id="126890308"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="233"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="394" mass="46473" checksum="3E7E3B3F7BC56256" modified="2025-10-08" version="1">MPRRVLDVDNFIFNVHAYFTAEKINGGPLRPVQSVHKRVCDALCISEKKLQSVLQKEKRGQSEQNAAQCKSRRHLKTVDLPEGCKFEIRETIYKMRERKEHVSLDSVLEKLKERKTFEISRTSLWRVLRQISFKFKKEDNRKALCERASVVHKRIEFFRNYKKFKKEFSSFVYLDETWIFSKGGIKRIWQDESTKSIKHTDTEGKRYIIVHAGGKHGFIEGADLVFSSKSKSADYHDNMNTEIFLKWLKEKLLPSLHEPSVIVLDNASYHSEILNKQPTNSWTVDKIKEWLTNKNITFPQYCFKPQLLTLAKSHAQPNIYMVDEIIHSFGHRVLRLPPYHCQFNPIEYIWGICKTYFDNHIGYKGYSEEAVLETWQEALDTATPEIWEKKCKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZC5</accession>
    <name>A0ABM5KZC5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515538.1">
        <property type="nucleotide sequence ID" value="XM_050659581.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659581.1">
        <property type="protein sequence ID" value="XP_050515538.1"/>
        <property type="gene ID" value="LOC126890555"/>
    </dbReference>
    <dbReference type="GeneID" id="126890555"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="316" mass="36380" checksum="F96C3AFD440CFFEE" modified="2025-10-08" version="1">MPGIQPMIVGIFHGNNKPLDIKEFLEPFVEDVKRLQSNGLCVNGHMIHIKIRCFICDSPARAFIKGVVNFNGINGCLKCTTEGEYSYLSRTVVFPDIKCPLRTDAKFRSKHYGKHHKGQESPILKISEVDMVQDFIVADELHLLELGVMKRCLTGWKDGSMGFSSKLCARDIERISKHLISVKLPSEIHRSTRGLDCLAYWKGVEWRNFLNYIGIVILKDVLNTDVYKHFLLLFVAVRICSSDMYAENRSVAQLMFEKYIDDFKIIYGVQFITSNIYNLEHVVDDVNRFGQLFTISTYHFENTLFQLKKLLRQGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L151</accession>
    <name>A0ABM5L151_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516161.1">
        <property type="nucleotide sequence ID" value="XM_050660204.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660204.1">
        <property type="protein sequence ID" value="XP_050516161.1"/>
        <property type="gene ID" value="LOC126891026"/>
    </dbReference>
    <dbReference type="GeneID" id="126891026"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="274" mass="32241" checksum="68B6327D11690EE3" modified="2025-10-08" version="1">MASKPTCSTSVNKQNKKRWLSVREKQMIKSVYEGLRRRYQDMLKEDVAALCGDLTKVSARTVFRIIKGNKPIQKPIHKGRAKIVLDDSTKSIIRRKVHGFYLRNELPTLKDIQREVNADADDTLNKISMRVLRRTLHEMDFRYVKRSRKSLLIERDELVIWRRKYLQKIRDFRRLNKKIYYTDETWLNEGHTKSKVWQDLNIKSARQAFIEGLSTGLKAPSGKGRRLIITHIGSDSGFLQGGLNVFTSIKTSDYHEDMNSDVFEKWFSSIYRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1M3</accession>
    <name>A0ABM5L1M3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516341.1">
        <property type="nucleotide sequence ID" value="XM_050660384.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660384.1">
        <property type="protein sequence ID" value="XP_050516341.1"/>
        <property type="gene ID" value="LOC126891202"/>
    </dbReference>
    <dbReference type="GeneID" id="126891202"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15061" checksum="18E6E3BE1C9208D0" modified="2025-10-08" version="1">MERHDIQKLCIHYLRAINRYREEGRPIVYMDTYIHSTHTTRKSLSDDSKEGVKQPTSKGNRLIIVHAGGECGFIQGAALVFKSGVKTGDYHDDMSFENYSKWFENKLIPNLPPQSVIVIDNAPYHKKPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2F2</accession>
    <name>A0ABM5L2F2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516610.1">
        <property type="nucleotide sequence ID" value="XM_050660653.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660653.1">
        <property type="protein sequence ID" value="XP_050516610.1"/>
        <property type="gene ID" value="LOC126891475"/>
    </dbReference>
    <dbReference type="GeneID" id="126891475"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="124" mass="14598" checksum="912FE489D20E256F" modified="2025-10-08" version="1">MSPHMNDETTCKKTPKDPTSEGSTMTITDFKKLLVEHLTSEKKTIENNINNNLKHKQHELEQLEGESKHKRRKMCKQRYKMNNNKHGRKFATNRTKKVNTYCKDCSNKHPLCLPCFNQIHTNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L429</accession>
    <name>A0ABM5L429_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 70 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517188.1">
        <property type="nucleotide sequence ID" value="XM_050661231.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661231.1">
        <property type="protein sequence ID" value="XP_050517188.1"/>
        <property type="gene ID" value="LOC126891890"/>
    </dbReference>
    <dbReference type="GeneID" id="126891890"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="28322" checksum="50B04F7E14F545E2" modified="2025-10-08" version="1">MSIILVCRRVLNSYSRSNILNIVNGCKLHSNGSFLYKNNTSLISKRSFFNLFRKPTRDKLYVLDNVPDHFEIIHRNRMERYILVTRLGTWITSSIVFVFIILKYGSPKNHMEFIGSRTDVQRSSQNEFEIYLAMFTGLIVTLHLLIMKMPLRIYYSSPLKKYTMIVPSHLPFDNKRLSFTIGQLQKLPMTGILPWRDARYRIKYENDEKSLILMEDHFRKPADLWIMLGVQRDPNHEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5C2</accession>
    <name>A0ABM5L5C2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050517638.1">
        <property type="nucleotide sequence ID" value="XM_050661681.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661681.1">
        <property type="protein sequence ID" value="XP_050517638.1"/>
        <property type="gene ID" value="LOC114346341"/>
    </dbReference>
    <dbReference type="GeneID" id="114346341"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF29">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045864650" description="Sphingomyelin phosphodiesterase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="290"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="13">
        <location>
            <begin position="522"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="645" mass="74128" checksum="B132F5645CB547C3" modified="2025-10-08" version="1">MKWSHIGLLSIAVLVNSAWSQGVENEALHGNSPSLNGTIDVSSLDGMPDVDSSLIGSEPFDRNRPITDGEIKRIQREFAKLIGLRRYQEIAPIRFRNLLRDILEIPVMKLFSIHSSCDMCKELVNIIHGRGYANSKVAEFICQVYYLMANLSFPTFCSAMEKQNLPVLEYVFYNMWNRNVSKKVDPELVCAIVLQTENCTYPKAALSWTTQIPRKIPKYPKHEKDPNKRTLKILHLTGPHISYDYEENGAVDCGAPLCCKNGLGENKTNGRKAGHWGEYTCDIPKWLFGDTLEQISKNHKNLDFIYFTGGIKDHTHWKSSTYTQQADIIFHTFKTLIESFPEIPVFPVIGNHEPSLPNQFAPNLPDIYSKGLSNKMLYVDFAAFSQSWLHENTLKTIQSQGYYAHTVSGRLKVIGLNNNVCYKFNWWLLLQTRFIDEQLQFLVRELEKSERYEQYVHILTHLPVGNNDCIQPWEASYTKIVERYAHIIKGQFYGHTGTDGFKIFYDTYSRPINAAFNGANLSPYQNSNPAYKIVHVHPDTMDVVDIETHYFNLTEANLSPNKSPNWKKLYAMKEAYDLSDLSPKSLNDLVDVLFTDTDLMINYWKYSVRLADPSLNELCNLNCRHKIRCKIVTTISGQPKRRRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L686</accession>
    <name>A0ABM5L686_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM122A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517951.1">
        <property type="nucleotide sequence ID" value="XM_050661994.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661994.1">
        <property type="protein sequence ID" value="XP_050517951.1"/>
        <property type="gene ID" value="LOC114340681"/>
    </dbReference>
    <dbReference type="GeneID" id="114340681"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30791" checksum="36FF3BF8AA6E7B06" modified="2025-10-08" version="1">MSFSNFSQSSAMDIDGPSPSSGPGTLKRCSSAPMINESTSVMTTSPSSSNRELQPFSFGSSQMRTRRFSASFSQVPGSPVLGPRLTPRINQLRQEEHEGISNTRELAHEREIHHAMQISQSWEDLSLMNDSNDTAKNNRLGSLQLNLQVGGGNIFTCNSPSPTRMGFQSPTRSRTIVRRSASPVLRPSPLGVKRKLDDVDYHLSPRAKRVYSYSGGAERGGLLTTIGTSHPGSLSSVGTPESLSSADSPGFNNFRNIDSPSPGRAMPIDSLSLSKNDQEMSESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9B4</accession>
    <name>A0ABM5L9B4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519028.1">
        <property type="nucleotide sequence ID" value="XM_050663071.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663071.1">
        <property type="protein sequence ID" value="XP_050519028.1"/>
        <property type="gene ID" value="LOC126893124"/>
    </dbReference>
    <dbReference type="GeneID" id="126893124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50100" checksum="41A2969BB904245D" modified="2025-10-08" version="1">MGVQKISAVNSKNLAKLVDTFLENLAALKTLGLPTEHWDFIMFNLLLSKLDVDSIKLFELKNKSNEIPSFKKLVAFIETQYIAYDNLDSSIGEGKKSSRAPNSTEPRANSRHQTGDSRHNRSSSSFVTNSSSVCCALCKQSHYLNQCSLFLKKSPKERYQFCKESSSCFKCLNQANHSVKSCPKSFRCSKCSSHLHNSLLHFERNRSNSQSSSENNSPGTSGIESSPEVSHCAASFVGNKNETKKEILKQPLRCLIDSGSMSSFISRKAANQLGWPKTPCSFEVNGLNSMQTKLNQGQISFSIQPRHQESPVFHLEAIITDRVCSDLPSTHIDISAWNYIKNLKLADPKFNCSQSVDLLIGCSIFSKVLLEGKIEGKPGQPDALNTVFGYILLGPTSTPNLSSTCSSSSSLVCLSNVKDSLDSSLRKFLGTGEHTGRASFRTGRRSVRNHVSGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2G0</accession>
    <name>A0A6P7F2G0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chromatin-remodeling complex ATPase chain Iswi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114325883</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129819.1">
        <property type="nucleotide sequence ID" value="XM_028274018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2G0"/>
    <dbReference type="FunCoup" id="A0A6P7F2G0">
        <property type="interactions" value="2160"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274018.2">
        <property type="protein sequence ID" value="XP_028129819.1"/>
        <property type="gene ID" value="LOC114325883"/>
    </dbReference>
    <dbReference type="GeneID" id="114325883"/>
    <dbReference type="KEGG" id="dvv:114325883"/>
    <dbReference type="InParanoid" id="A0A6P7F2G0"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="144"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="439"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="795"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="758"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028129819.1"/>
        </source>
    </evidence>
    <sequence length="1019" mass="118763" checksum="F8A5A9D906984E4E" modified="2020-12-02" version="1">MSQTEGSTEASVSASEPMEEAENSELAQNEESSSDTTSKGEEFEVKVASDRGKRFDYLLKQTEIFSHFMNQTKSPSKPKTGRPKKEKSDTSDLRHRKTEQEEDEELLAETNLKTKTTTRFDASPPYIKHGEMRDYQVRGLNWMISLYEHGINGILADEMGLGKTLQTISLLGYMKHYKSTPGPHIVIVPKSTLSNWMNEFEKWCPTLRAVCLIGDQEARSSFIRDTMMPGEWDVCVTSYEMCIKEKSVFKKFNWRYMVIDEAHRIKNEKSKLSEILREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSSDDFDAWFNTSQCLGDNALVERLHAVLKPFLLRRLKAEVEKRLKPKKELKVYVGLSKMQREWYTKVLMKDIDIVNGAGKVEKMRLQNILMQLRKCTNHPYLFDGAEPGPPYTTDEHLVYNCGKMVLLDKLLPKLKEQESRVLIFSQMTRMLDILEDYCHWRQYQYCRLDGQTPHEDRQRQINEYNEDNSQKFIFMLSTRAGGLGINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRFITENTVEEKIVERAEVKLRLDKLVIQQGRLADSKAQTLNKDEMLNMIRHGANHVFASKDSEITDEDIDSILEKGEMKTAQLAQKMETMGESSLRNFTVETPTESVYQFEGEDYREKQKTIGLSNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPIVQDFQFFPPRLFELLDQEIYFYRKSLGYKVPKNLELGPDASKQQKEEQRKIDESEPLTEDEQQEKENLLTQGFTNWSKRDFNQFIKANEKYGRDDIENIAKDVEGKTPEEVMEYSAVFWERCHELQDIDRIMAQIERGETKIQRRASIKKALDAKMARYRAPFHQLRISYGTNKGKNYMEDEDRFLVCMLHKLGFDRENVYEELRAAVRASPQFRFDWFLKSRTAMELQRRCNTLITLIERENAELEEREKIDKKKKVSKSSNLGGIPAQISSKSSQKRKNDTSAGGVEKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2N1</accession>
    <name>A0A6P7F2N1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Splicing factor 3B subunit 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325669</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129591.1">
        <property type="nucleotide sequence ID" value="XM_028273790.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F2N1">
        <property type="interactions" value="2176"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273790.2">
        <property type="protein sequence ID" value="XP_028129591.1"/>
        <property type="gene ID" value="LOC114325669"/>
    </dbReference>
    <dbReference type="GeneID" id="114325669"/>
    <dbReference type="KEGG" id="dvv:114325669"/>
    <dbReference type="CTD" id="23451"/>
    <dbReference type="InParanoid" id="A0A6P7F2N1"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000541">
        <property type="entry name" value="Splicing factor 3B subunit 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001513">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="901"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028129591.1"/>
        </source>
    </evidence>
    <sequence length="1329" mass="149480" checksum="3969093142FCB6D0" modified="2020-12-02" version="1">MDNIPRTHEDIEAQIREIQSKKKEIPTEKPDEKKSKLGEGGYFDDEIYETGKGKYEGYVTSIAANDEVDDDEEDVGFSSKRTGLGGRVALLNDVAESEKGYDPFADRRRPTIADREDEYRQKRRRMIISPERVDPFADGGKTPDFQTRNYSQIMKEQLLKGEEAEIRKQLIERAKDGTLKATNGEAKSAPKKRGRWDQTVDEVIIPQKKKTLSIPSSGSNAATPVWEGDKTPSDIRWDETPGHKGSETPGATPGQSTRMWDATPGPATPGRETPGHGDKSTSRRNRWDETPKTERETPGHNSGWAETPRTDRTGADLIQETPTPGASKRRSRWDETPSATPSQVMTPGAMTPTTPHGTPHATPSHGNSTPMLTPGGSTPVGSKAMGMQTPTPGHLASMTPEQLQAYRWEREIDERNRPYSDEELDAMFPPGYKVLPRPAGYIPIRTPARKLTATPTPMIGSTHTPTGFFIQQEDRSAKYMDNQPKGQNLPFMKPEDAQYFDKLLVDVDEEALSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIDNIDEYVRNTTARAFAVVASALGIPSLLPFLKAVCRSKKSWQARHTGIKIVQQIAILMGCAILPHLKSLVEIIEHGLVDEQQKVRTITALGIAALAEAATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCSTDGVEAQYIKEEILPQFFKHFWNHRMALDRRNYRQLVDTTVEIANKVGASEIINRIVDDLKDENEAYRKMVMESIEKIMGNLGAADIDSRLEEQLIDGILYAFQEQTTEDVVMLNGFGTIVNQLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISRIAVVMKTCLEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMTKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGPEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVAPLLEDALMDRDLVHRQTACAAIKHMALGVYGFGCEDALIHLLNYVWPNIFETSPHLVQAFMDAIEGMRVALGPIKILQYTLQGLFHPARKVRDVYWKIYNSLYIGGQDTLVAGYPRIMNDPKNQYIRYELDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9K6</accession>
    <name>A0A6P7F9K6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Erlin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327143</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131462.1">
        <property type="nucleotide sequence ID" value="XM_028275661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9K6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275661.2">
        <property type="protein sequence ID" value="XP_028131462.1"/>
        <property type="gene ID" value="LOC114327143"/>
    </dbReference>
    <dbReference type="GeneID" id="114327143"/>
    <dbReference type="KEGG" id="dvv:114327143"/>
    <dbReference type="InParanoid" id="A0A6P7F9K6"/>
    <dbReference type="OrthoDB" id="77368at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03406">
        <property type="entry name" value="SPFH_like_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000009">
        <property type="entry name" value="Erlin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033294">
        <property type="entry name" value="Erlin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351:SF3">
        <property type="entry name" value="ERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351">
        <property type="entry name" value="ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="10">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131462.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38389" checksum="2B5FD007ABE0A4ED" modified="2020-12-02" version="1">MPRPSSLTEHFIIGTILSCIFLIFNYSLHRIEEGHVGVYFRGGALLPSVSFPGYHMMIPLLTSFKSMQITLQTDEVKNVPCGTSGGVMIYFDRIEVVNHLNQNSVLDIVRNYTADYDKTLIFNKVHHELNQFCSIHTLHEVYIDLFDQIDENLKQALQRDLLEMAPGLTIQAVRVTKPKIPEVIRKNYELMEGEKTKLLIATQHQKVVEKDAETERKKAIIEAEKEAQVAKIQFEQKIMEKESLQRISQIEDEMHLARQKSHADAEFYKHKQQAEVNKMLHTREYIELKKYEALSHNTKVYFGNEIPQAFLGSEITTFADTKTSVGESKTSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB20</accession>
    <name>A0A6P7FB20_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein OZF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114328433</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133084.1">
        <property type="nucleotide sequence ID" value="XM_028277283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB20"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277283.2">
        <property type="protein sequence ID" value="XP_028133084.1"/>
        <property type="gene ID" value="LOC114328433"/>
    </dbReference>
    <dbReference type="GeneID" id="114328433"/>
    <dbReference type="KEGG" id="dvv:114328433"/>
    <dbReference type="InParanoid" id="A0A6P7FB20"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002650">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028133084.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62803" checksum="2B6B1A2C78EEE368" modified="2020-12-02" version="1">MVEPDTVFTSLDSLCRTCLNEKTADELRSFSENSLRQELKEITSIEVQENDGLPYLICNNCCYTLNVAINFKTQCLKSDSHLKAVLFPVESTIIYKSITILDNNNSNDLCLEIYDDQDVPNTNNVEVAADNRIQIVKNFDDINNIRNVSQNIDTEVANPAVLDNMASINNQSVIKFYPKAKTKEASQRNKSKLFLCEICNKEFIFETTLRSHLVTHGKKIACEVCHQQFNVMKIYKSHMTSKHPDYRPYKCAHCSKDFAASDTLIKHMRIHGGERKHLCTVCGKRFYEPNHLLIHSRVHTGEKPLSCMTCGKRFTNRHGLVAHNKVHTGERKYQCNTCGKRFAHSFVLTAHKRVHTGEKPYKCSTCKASFGSSSYLKIHERIHTQEMPYKCETCSKSFISKTRLLSHQVIHSKEKSHQCSICGKTFSRSRDMQVHIRSHTGEKPYACDQCDKRYITSSNLAAHKRTHLGIKNYICSTCGKAFGDPRTLKGHYRIHTGEKPYLCNICGNSYSQSGQLSVHKRVHENKHNEVVVNLEKDVVWYNVFESARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCD8</accession>
    <name>A0A6P7FCD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Histone acetyltransferase</fullName>
            <ecNumber evidence="20">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC114327965</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54020"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13758"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:138019"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54021"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM (via its Tudor-knot domain); possibly regulating the activity of ATM. Interacts with NELFD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="20"/>
    <dbReference type="RefSeq" id="XP_028132492.1">
        <property type="nucleotide sequence ID" value="XM_028276691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCD8"/>
    <dbReference type="FunCoup" id="A0A6P7FCD8">
        <property type="interactions" value="1496"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276691.2">
        <property type="protein sequence ID" value="XP_028132492.1"/>
        <property type="gene ID" value="LOC114327965"/>
    </dbReference>
    <dbReference type="GeneID" id="114327965"/>
    <dbReference type="KEGG" id="dvv:114327965"/>
    <dbReference type="CTD" id="31518"/>
    <dbReference type="InParanoid" id="A0A6P7FCD8"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005705">
        <property type="term" value="C:polytene chromosome interband"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000039">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="22">
        <location>
            <begin position="168"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_028132492.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="53523" checksum="B144715043A6CF0F" modified="2020-12-02" version="1">MADFKRQDFNEEIMPKKSDNENKPNIQDEDSESAEEQPLDVGEHYLVRRSDDTWHPAEIIQSRFNELERQYEYYVHYEGYNRRLDEWVPRGRIMSSRFNMTESGQKGMLDMKVLRDRPLINDLLSDNSDRKITRNQKRRHDEINHIQKTYAEMDPTTAALEKEHEQITKVKYIDKIQIGRFEIDTWYFSPFPEEYGRQSKLWICEYCLKYMRLEKSYRYHMSECTQRQPVGKEIYRKGTLSVYEVDGKDHKVYCQNLCLLAKLFLDHKTLYFDVEPFLFYILCEVDKQGAHIVGYFSKEKESPDGNNVACILTLPPYQRQGYGKLLIAFSYELSRLEGTVGSPEQPLSDLGKLSYRSYWSWVLLEVLRGFRGTISIKDLSQMTSISQTDIISTLQSMNMIKYWKGHHVICVTPKLVEEHIKSSQYKRPRLCVDSTALRWTPRRHVNSKLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCQ9</accession>
    <name>A0A6P7FCQ9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Transmembrane protein 53-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14" type="primary">LOC114328972</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133773.1">
        <property type="nucleotide sequence ID" value="XM_028277972.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133774.1">
        <property type="nucleotide sequence ID" value="XM_028277973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133775.1">
        <property type="nucleotide sequence ID" value="XM_028277974.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133776.1">
        <property type="nucleotide sequence ID" value="XM_028277975.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133777.1">
        <property type="nucleotide sequence ID" value="XM_028277976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCQ9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277972.2">
        <property type="protein sequence ID" value="XP_028133773.1"/>
        <property type="gene ID" value="LOC114328972"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277973.2">
        <property type="protein sequence ID" value="XP_028133774.1"/>
        <property type="gene ID" value="LOC114328972"/>
    </dbReference>
    <dbReference type="GeneID" id="114328972"/>
    <dbReference type="KEGG" id="dvv:114328972"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028133773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028133774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028133775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028133776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028133777.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32939" checksum="3AF4E73A0B883E3F" modified="2020-12-02" version="1">MADLDNLEYYIKFPNPNFNYNQNGDHDFVFIVNEEKIPVILLFGWAGCQDKYLAKYSQIYEEKGLITLRYTAPIKCLFLRRYQMISIGEKLVKLLFDLNFDNHPIIIHCFSNGGAFLYQNFSLALEKCPKQLPIKGVIFDSAPGRRRILSLFRAISAIIGGNKIYNFSVSFIMTMFLSMIWLYEVISNTIYPRPSFQSNPLENLKNEKHRWPQCFIYSKKDDLIYYKDIEYFSNYRKNMGIDITSVCYEKSLHVKHLAENRDSYLKTVYNFINKCLNGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFC8</accession>
    <name>A0A6P7FFC8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114329732</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134729.1">
        <property type="nucleotide sequence ID" value="XM_028278928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFC8"/>
    <dbReference type="FunCoup" id="A0A6P7FFC8">
        <property type="interactions" value="1651"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278928.2">
        <property type="protein sequence ID" value="XP_028134729.1"/>
        <property type="gene ID" value="LOC114329732"/>
    </dbReference>
    <dbReference type="GeneID" id="114329732"/>
    <dbReference type="KEGG" id="dvv:114329732"/>
    <dbReference type="CTD" id="40272"/>
    <dbReference type="InParanoid" id="A0A6P7FFC8"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000537">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028134729.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="45573" checksum="C69600E77EFD2A81" modified="2020-12-02" version="1">MAVVILTGSKLITKQPGLVAVAYIRSNNYSTEDRAYNLASLKRGTGGRSSFNGIVATVFGATGFLGRYVCNRLGKIGSQIIIPYRGDNYEPFRLKLVGDLGQVYFHPYHLRDEESIAKCIKYSNVVVNLVGRDWETRNFKFDDVHVDGARRLARLAKQAGVERFIHLSSINADENPQRAGILKGGSNFLRSKARGEEAVLEEFPEATIFRPSDVYGQEDRFVRYYAHPWRRSANYFPLWHKGERTVKQPVYVSDVTSGIINAIKDPDTAGKIYQAVGPKRYLLSDLVDYFHRIMRKDDEWGYKRYDMRWDPLFQLRVSLTEKFSINWPIGHLHWEKIEREHLTDDVKSDIPTLEDLGVNLTAVENQMPWEFKPWTWGIYRGQDPDEPVAPAAPPKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFH4</accession>
    <name>A0A6P7FFH4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114329596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114329596</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134561.1">
        <property type="nucleotide sequence ID" value="XM_028278760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFH4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278760.2">
        <property type="protein sequence ID" value="XP_028134561.1"/>
        <property type="gene ID" value="LOC114329596"/>
    </dbReference>
    <dbReference type="GeneID" id="114329596"/>
    <dbReference type="KEGG" id="dvv:114329596"/>
    <dbReference type="InParanoid" id="A0A6P7FFH4"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028134561.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12066" checksum="CA1448090629CE6D" modified="2020-12-02" version="1">MTDESKNVEVHNHYHIYPKINLNFHIFGNNGVGFSMPAEQFIKPMLNNLPSSETVTKALKDGSSIVASGSSSSYNWLRGNTGYITNTVKSGSGMIASGTSASYNWLFKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH70</accession>
    <name>A0A6P7FH70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114330125</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135276.1">
        <property type="nucleotide sequence ID" value="XM_028279475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH70"/>
    <dbReference type="FunCoup" id="A0A6P7FH70">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279475.2">
        <property type="protein sequence ID" value="XP_028135276.1"/>
        <property type="gene ID" value="LOC114330125"/>
    </dbReference>
    <dbReference type="GeneID" id="114330125"/>
    <dbReference type="KEGG" id="dvv:114330125"/>
    <dbReference type="CTD" id="11224"/>
    <dbReference type="InParanoid" id="A0A6P7FH70"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028135276.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14351" checksum="0FD284D3139C93E9" modified="2020-12-02" version="1">MGKVKCADLRTKDKKELTKQLDELKTELTSLRVAKVTGGAPSKLSKIRVVRKAIARVYIVMHQKQKENLRKLYKNKKYKPLDLRPKKTRSIRRALSTHEQRIKTPKEIRKRSAFPARKFALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI03</accession>
    <name>A0A6P7FI03_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114329619</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134592.1">
        <property type="nucleotide sequence ID" value="XM_028278791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI03"/>
    <dbReference type="FunCoup" id="A0A6P7FI03">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278791.2">
        <property type="protein sequence ID" value="XP_028134592.1"/>
        <property type="gene ID" value="LOC114329619"/>
    </dbReference>
    <dbReference type="GeneID" id="114329619"/>
    <dbReference type="KEGG" id="dvv:114329619"/>
    <dbReference type="CTD" id="254295"/>
    <dbReference type="InParanoid" id="A0A6P7FI03"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028134592.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32616" checksum="A2AAE350517841BE" modified="2020-12-02" version="1">MFDDVKRKFETEGFAVIENLFTPEEVEEMKNEAQNLIKSMPGESKRTVFSTTHSESQQNKDKYFLDSGDKIAYFYEQGALGPNGELLVEPENSLNKIGHALHELNPVFKKHTFSEKIKEAAFQLGFEEPVIPQSMYIFKNPKIGSEVTAHQDASYLHTDPLKVAGFWIALDDATVENGCLWFSRRSHNGGIHRRFIRNPDPNADELLIYNSAAPYYQKSSFSPVPVTKGSCILIHGQVVHYSEANKSDKSRHAYTFHIVESKNTTYSKDNWLQPTNRQFLNLYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMV5</accession>
    <name>A0A6P7FMV5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114331962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114331962</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137456.1">
        <property type="nucleotide sequence ID" value="XM_028281655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMV5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281655.2">
        <property type="protein sequence ID" value="XP_028137456.1"/>
        <property type="gene ID" value="LOC114331962"/>
    </dbReference>
    <dbReference type="GeneID" id="114331962"/>
    <dbReference type="KEGG" id="dvv:114331962"/>
    <dbReference type="InParanoid" id="A0A6P7FMV5"/>
    <dbReference type="OrthoDB" id="6755943at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028137456.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="33200" checksum="F4E05D76165C9233" modified="2020-12-02" version="1">MVRPEVLQEIKNNILKYEYPLANTMTDEELADIFKASNRPFLMAWMIKLLGTYEEAIVTVDNPQLLGHMMYENGFCTKDQADSFMNGFMSPTGQFEILQKMFIYMNIIKKPKPELDFKDITLPDIDDLFNKNLNLFPQYGEIKILTQEKNVSAATENNVKDQESAADPFETSNNADITKLLADVQLHLPILKKVVKECQKDEDANSDILLQRNDEVEKVVKKCSSYLRKINQYLKDVKTIQEFFNNNEECLAKPSDRKHSEAHRQMLRSLHIEVSSILRILNAITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FS60</accession>
    <name>A0A6P7FS60_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic AMP-dependent transcription factor ATF-6 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114332109</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137637.1">
        <property type="nucleotide sequence ID" value="XM_028281836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FS60"/>
    <dbReference type="FunCoup" id="A0A6P7FS60">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281836.2">
        <property type="protein sequence ID" value="XP_028137637.1"/>
        <property type="gene ID" value="LOC114332109"/>
    </dbReference>
    <dbReference type="GeneID" id="114332109"/>
    <dbReference type="KEGG" id="dvv:114332109"/>
    <dbReference type="CTD" id="22926"/>
    <dbReference type="InParanoid" id="A0A6P7FS60"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14700">
        <property type="entry name" value="bZIP_ATF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051882">
        <property type="entry name" value="ATF_bZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164:SF3">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028137637.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="72334" checksum="6058EE0F89F8874B" modified="2020-12-02" version="1">MLTTDDFLLDDYVFKSSPESCSDHSSSTDFMEVTSDEDFLTQLSADLDIPLLLNQGEDELSMLNSLLFDKSPEEILSETASPPYIPEDDFPKEVSELQKMDFSQCGPESFPNLHSDVKIEPADSPRSSKSASPVSLEHVKDEVIIKTPPASPVIINAVKEVPNNVIFAQPVKLLSQSHNLPQKHIPIVPKAHYSLPVSKNNVVVINTDLKPVVKQRNMVLVENVNVTTVPQIPVPNVPVNTVTNLNKPVTVPSVVIDRANNFSLNGRSIDPKILKRQQRKIKNRESASLSRKKKKDYVTSLEEQVKELSAENKRLQAENIQLKETLIQYEVNPISKGSRNVKPSVYLYICLLVIGVNLNFVRNPFSTKTEVELVRSNIPRLTDHHGRGLLWTEENDANENKTSPFSPFFMCPATINQTESARLVLELERWIGKPADLSTKVTLDLNASVPINSTGNTKKARPKRKKKYRLDSSLTSYKRYKHYRHDDDSPKNEIQVFSVRPEQLYSDFFEAINRQDDTFYVVSFTDQHMLLPALHHNKTRRPKMSLIMPSMLPNKTRSQSSLIPLMQIDCEVLDTRWIHVKHGVIPPRFKMHSNTTQTEPDDSKASVSDANATNQEYYDKSYKPYFMKPKEGIFTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSJ7</accession>
    <name>A0A6P7FSJ7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable insulin-like peptide 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114333638</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139369.1">
        <property type="nucleotide sequence ID" value="XM_028283568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSJ7"/>
    <dbReference type="FunCoup" id="A0A6P7FSJ7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642072.1">
        <property type="protein sequence ID" value="XP_050498029.1"/>
        <property type="gene ID" value="LOC126879119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FSJ7"/>
    <dbReference type="OrthoDB" id="10044229at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04365">
        <property type="entry name" value="IlGF_relaxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028146512" evidence="3">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028139369.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="17242" checksum="2372397500B69BB9" modified="2020-12-02" version="1">MWLPVSTIAAICVFIDATEGTGTENDLDVVFKGRTHSDWKNAWHQEKFSRCRDTLIKHLYWACEKDIYKLTRRSDPSLNKIEEYDDYNEFNFPWKTRQDAKGILRFRRNRRSGSSITHECCKSSGCTWEEYAEYCPTNKRYTTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTM7</accession>
    <name>A0A6P7FTM7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114331042</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136308.1">
        <property type="nucleotide sequence ID" value="XM_028280507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTM7"/>
    <dbReference type="FunCoup" id="A0A6P7FTM7">
        <property type="interactions" value="763"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280507.2">
        <property type="protein sequence ID" value="XP_028136308.1"/>
        <property type="gene ID" value="LOC114331042"/>
    </dbReference>
    <dbReference type="GeneID" id="114331042"/>
    <dbReference type="KEGG" id="dvv:114331042"/>
    <dbReference type="InParanoid" id="A0A6P7FTM7"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="161"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028136308.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="66834" checksum="C5F020E96CCFAAC4" modified="2020-12-02" version="1">MPQGRRKVPFSGKAKKEQLKAKRQSKQGSRNTPFLLKKHDEGETSGVDVEKLNFQPTRDGGSRPNRYALQFFKESQQEVLRQKEIARHSLEPKEEKDLEIDGSEYFDKALDFPKRPPWEYGVEKNQLEAQEHRYFTEYIKNIQEKYDWKELSLFELNLETWRQLWRVLEMSDIVLFIVDIRFAALMFPPSLYEYVTDTLKKNFILVINKIDLAPPSLVVAWKHYFKEKYPNLHIIMFTTVPGYNLQGKQSNVAGLQVRRRKGRIRMAAEGAQQILESCKKIVASQVDLSSWSNKIKEEMNVEYNDQSEDVDIGEIVHTKNVDTEFFQYEKFNKGILTIGCLGQPNVGKSSVMNALMGKKVVSVSKTPGHTKHFQTIFLTSNVRLCDCPGLVFPSKVTKPLQVLMGSFPIAQLRQPFTTVKYIAERLDLVSILKIEHPTNDDTWSAMDVCDGWAKKKGFYTAKAARLDSYRAANSLLRMALDGKICLCLRPIGYSDKQDFWKQHPDVKVVEWILAKSDVETEECTAYDSDSSEELPKIYGVNQQKVEESNKSQDETDTDSDEDDEDIRLTKNKFAALSADLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUN8</accession>
    <name>A0A6P7FUN8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114334224</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028140061.1">
        <property type="nucleotide sequence ID" value="XM_028284260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUN8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284260.2">
        <property type="protein sequence ID" value="XP_028140061.1"/>
        <property type="gene ID" value="LOC114334224"/>
    </dbReference>
    <dbReference type="GeneID" id="114334224"/>
    <dbReference type="KEGG" id="dvv:114334224"/>
    <dbReference type="CTD" id="9100"/>
    <dbReference type="InParanoid" id="A0A6P7FUN8"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000092">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="288"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028140061.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="75161" checksum="2FD7196B0C1223C1" modified="2020-12-02" version="1">MDSDELRNIEFIDLNGVDEKEQLHIRNSLQQYDPSVQLPWVKEKKSFAEGKCQQKNKEPDLSNIQQPVIPSSAHHEHHNPYIQHPIIPQSVYCNHLQPSVVVQPIITIPHPPNIVYYATNAMSPVSPPYPQVFISHRTYSPPTTYALPVHVPEGAVNEMVPKQNGVTEDKEIHENGATAKAPEVTPKTPVVVNGIDNVETPSPAPANKSWASLFSSSKPNTSPTTAKETKEKNNSEQAVNKESNNNTQLCPIKHPRKSHQFVDPDCYRMGEYLLSYVIDGKALSLQPRGLLNQSNYCYINSILQALIACPPLYNLLIGLAQNISSNEKRKPTPVIDGMCRFVKEFKHLPANLRVKDNKKADKNAKKDLNVMINTDIPFEPTWIYKMLNAIRTDLIEGRQEDAEEFLGFLLNGLNDEMLELIKLVKSDFDEPLEAPTQIEDDADKEWKVMGPKNKGSITRRTDFDRTPISDIFGGLLKSRIQRTGDLNTENIQPFLTLQLNIEKVKTVREALEVLVNRHQLEGLTSSKTNEEVEAWQQVLLDELPVILILHLKCFDYKQDGCTKIVKALEFPVDLKIDQKLLASKIQIQKEKHYKLFAVVYHDGKEASKGHYVTDAFHVGYSSWLRYDDASVKTVQEEQVLKPQGTRVPYLLFYRRSDTIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW70</accession>
    <name>A0A6P7FW70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Trehalase</fullName>
            <ecNumber evidence="3 7">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114333371</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 7"/>
    <dbReference type="RefSeq" id="XP_028139037.1">
        <property type="nucleotide sequence ID" value="XM_028283236.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028139038.1">
        <property type="nucleotide sequence ID" value="XM_028283237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW70"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646808.1">
        <property type="protein sequence ID" value="XP_050502765.1"/>
        <property type="gene ID" value="LOC126882033"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646809.1">
        <property type="protein sequence ID" value="XP_050502766.1"/>
        <property type="gene ID" value="LOC126882033"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650967" description="Trehalase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028139037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028139038.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="66832" checksum="6C177A0E5C72FA3B" modified="2020-12-02" version="1">MGHHVTVLLAIAFIASTVYANSIPSCDSTIYCQGKLLHTIQMARLFPDSKTFVDMQQKHPAQVTLQNFEQLMSDKKDNPSREDLIKFVNDNFESTGELVDWTPPDLNKNPKFLRRIDDPRVKNFAQSLVNVWPKLARKVSDSVREHADQHSLIDIPNGFIIPGGRFKEIYYWDSYWIVEGLLVSEMTETVRGVLENFLSIVERFGFIPNGARVYYLNRSQPPLLAMMMGKYIDQTGNKTWLEKHVDTLEKEMNWWWSERKVTVKKDGANYDMFMYAVKSDTPRPESYYEDIITCQNFTESEQKACYRNLKSGAESGWDFSSRWLYNDDRNPSTNLSQIDIIDVIPVDLNAILCRAFEELSRFYQLVGNNEKAEAWSHKHLNLRSAIQAVNYNDEDGIWYDFDVKHSSHRKEFYPSNFAPLWADAYDTTKKETFGIRAATYYRKMKVNTYAGGIPSSLLQSGQQWDMPNAWPPLQEFIVLGLRKTGSKKAERLAKSEAKKIVEAFMIGFETTKDMFEKYDARHPGEYGGGGEYVVQTGFGWANGEALTLINEFYAKSHKKHHKHGKSHQRHEKQRNNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G291</accession>
    <name>A0A6P7G291_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114336833 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114336833</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143016.1">
        <property type="nucleotide sequence ID" value="XM_028287215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G291"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287215.2">
        <property type="protein sequence ID" value="XP_028143016.1"/>
        <property type="gene ID" value="LOC114336833"/>
    </dbReference>
    <dbReference type="GeneID" id="114336833"/>
    <dbReference type="KEGG" id="dvv:114336833"/>
    <dbReference type="InParanoid" id="A0A6P7G291"/>
    <dbReference type="OrthoDB" id="6792752at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027849357" evidence="1">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028143016.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16739" checksum="EA87DABF8811891B" modified="2020-12-02" version="1">MKKLMLFGFAVFVVVLAVTKESIADTNKEQKLQGVLQKMHDHHNTCSKEFGQPPGYLIQGFQNIKKEDEAKVGAFSLCVLSKLGLISENGAIIEDGVRSFITDFHGDSDREKKLVQKVLTICKPLVDSQLTPQYKALAFAQCKEKQVKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3V5</accession>
    <name>A0A6P7G3V5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine proteinase stubble</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114335635</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141702.1">
        <property type="nucleotide sequence ID" value="XM_028285901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3V5"/>
    <dbReference type="FunCoup" id="A0A6P7G3V5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285901.2">
        <property type="protein sequence ID" value="XP_028141702.1"/>
        <property type="gene ID" value="LOC114335635"/>
    </dbReference>
    <dbReference type="GeneID" id="114335635"/>
    <dbReference type="KEGG" id="dvv:114335635"/>
    <dbReference type="CTD" id="35904"/>
    <dbReference type="InParanoid" id="A0A6P7G3V5"/>
    <dbReference type="OrthoDB" id="93664at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF10">
        <property type="entry name" value="SERINE PROTEASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027922705" evidence="7">
        <location>
            <begin position="20"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="613"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028141702.1"/>
        </source>
    </evidence>
    <sequence length="855" mass="92581" checksum="AA32E3CF2F216D4A" modified="2020-12-02" version="1">MLPAALVTLVTFLLEICSSSPVYNMQPAFITNTVGSTAGRNIRNLPCISRRNSNLSGYCMFAIDCLKANGTHLGTCIDGFYFGSCCHIEPVKDIIDNHIDTDIIPHREPPFRISSTTSRTPSTTSAQKNVSSTTLRTSTTTRSKSTSTTKIPVTSTGSIKPVSTTTSGLNISSLRTTISTSTSSTTLPEKLQTFQVVNTNNVQDEATKPSIITTVYSSSRPATKQPVTVTPTKSPSSIRPLSSSTAPIIPITKRPVQSSTTSIGPSNLTSATPTYSSVTASTTKAPVKLSTQTTSKPVISEITNKPTKTTRSPPTKATQKPTKPTKATLVTKKTQSTTKASSILTKPTKISTAKPTKRVTSSTERSTTTKPTRTTTQKIPTKSPISTLATSTHRVPISTPPSSTATSTESTSISMTTSKPNNTQTLQTVSGNIATNEIEDSHHSQQPTTNKPGGLITWTVVDNRNSSTTVSDQMFNSTTEDWVPITTPDGWVLLPSVSSNATMPPSMDSSTTVLPSSSVSSISTSSSTFGPITLPTPFDKPTVQNVTTEAPTATDSSSISSSTIEVVTIENETDTADNSTINTTPPLENFEQPVNMSDFTDVCGRRMYPEARIVGGEKSSFGKWPWQISLRQWRTSTYLHKCGAALLNENWAITAAHCVDNVPPSDLLLRLGEHDLSTESEPYLHQERRVQIVASHPQFDPRTFEYDLALLRFYEPVTFQPNILPVCVPQSDENFVGRTAYVTGWGRLYEDGPLPSVLQEVSVPVINNTVCESMYRAAGYIEHIPHIFICAGWRRGGFDSCEGDSGGPMVIQRQDNRFLLAGVISWGIGCAEPNQPGVYTRISEFRDWINQILQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4Y9</accession>
    <name>A0A6P7G4Y9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC114335966</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10 11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028142066.1">
        <property type="nucleotide sequence ID" value="XM_028286265.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028142067.1">
        <property type="nucleotide sequence ID" value="XM_028286266.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028142068.1">
        <property type="nucleotide sequence ID" value="XM_028286267.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509538.1">
        <property type="nucleotide sequence ID" value="XM_050653581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4Y9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286265.1">
        <property type="protein sequence ID" value="XP_028142066.1"/>
        <property type="gene ID" value="LOC114335966"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653581.1">
        <property type="protein sequence ID" value="XP_050509538.1"/>
        <property type="gene ID" value="LOC114335966"/>
    </dbReference>
    <dbReference type="GeneID" id="114335966"/>
    <dbReference type="KEGG" id="dvv:114335966"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650990" description="UDP-glucuronosyltransferase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028142066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028142067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142068.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59490" checksum="6D2BB51960827782" modified="2020-12-02" version="1">MKVLLFILSIPTTFGSNILMIDEILSPSHQIWNYVLVEALLDKGHHVTLIGPKTIDVIVHSNFTMYELEDLHKAVEEIMDPNEIQQYGIYGNLKLLYEYTDNTCFHISKSPTIQKLIQENRNTRFDLIVIDMSLGGCLLPVIEKFNYPPSIAVCPFLLVPYLSELFGNSVHPAFVPHMYSKFTSKMSYFERIQNYVYTYGEIYLWSRIYKTRRTEIAKMAFGEDVAPIEKLERHLSLVLTNIIMGFNYARPLTPNIIPVGGLHIRPARKLPNDIEQIITRSKHGVILFGFGTNIRTSDLNADRVRAILKALSRLNETVLWKFDGEIKDIPKNVILRSWLPQSDILAHPKTKLFISHCGALSTNEAVYRGVPIVAVPFIVDQHLLAEQMRVQRWATVVDFKTITEQSFFDAIYDVLNNPEYRKNIQKLSRIVRDQKETPLERSIFWIEYAMRHNGTHHLNPESRDLSLFVQSSLDVQLSLLFIAFIFLVVTIIVPFNFKEMLFSYQGKKTYKIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G568</accession>
    <name>A0A6P7G568_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Splicing factor 45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA-binding motif protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114337780</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144116.1">
        <property type="nucleotide sequence ID" value="XM_028288315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G568"/>
    <dbReference type="FunCoup" id="A0A6P7G568">
        <property type="interactions" value="1658"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288315.2">
        <property type="protein sequence ID" value="XP_028144116.1"/>
        <property type="gene ID" value="LOC114337780"/>
    </dbReference>
    <dbReference type="GeneID" id="114337780"/>
    <dbReference type="KEGG" id="dvv:114337780"/>
    <dbReference type="CTD" id="3355114"/>
    <dbReference type="InParanoid" id="A0A6P7G568"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12647">
        <property type="entry name" value="RRM_UHM_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000079">
        <property type="entry name" value="Putative splicing factor 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034653">
        <property type="entry name" value="SPF45_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031066">
        <property type="entry name" value="Splicing_factor_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028144116.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="43560" checksum="E449E21E61F2D9B5" modified="2020-12-02" version="1">MSLYDDYDVKTTATEKVQGWSSGIKLLQSQLQLKKATVTQPKRDQLRKSVSLAPVIDLKSKRDDDELKSLAKPKSDPWPPILSSAGDDLNIVNEYNPSWPNEFEKKVKELREHSRDRENREPRDRDRTDKEEKKKEKKRKSRFGDPEESMSPPSIVNSTPQMSQPQIGSGFSGRWNEEDEEEIAPKQPRPSGGAAIAPPPSLQEPSDPVPIIPTKPQPASSYGGSVAAKIMARYGFKEGQGLGRMEQGMASALQVEKTSKRGGRIIHEKEILAPPTIDQVTQPPTITEIMKNPSKVVLLKNMVGPGEVDDDLEPEVKDECNTKYGPVASVIIHEISSDNPEECVRIFVEFLRIESAIKAVVDLNGRFFGGRQVKAAFYDTEKFDNLQLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G842</accession>
    <name>A0A6P7G842_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elastase-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114338875</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145306.1">
        <property type="nucleotide sequence ID" value="XM_028289505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G842"/>
    <dbReference type="EnsemblMetazoa" id="XM_050661674.1">
        <property type="protein sequence ID" value="XP_050517631.1"/>
        <property type="gene ID" value="LOC126892191"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G842"/>
    <dbReference type="OrthoDB" id="5597713at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027849359" evidence="2">
        <location>
            <begin position="16"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028145306.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29828" checksum="D127624BDC6403F9" modified="2020-12-02" version="1">MLIWVLLGVFEFVSGGKTAAIVNGFHRAREPALGDFPFQASLMLQVNNTSYLTFCGGSLIHPKWILTAAHCLEQDGKPFPTNIVTVALGSIFTNGSKAQRLAVQSFYIHKKYFETNGGFDIGLIKLRTNARLGKNVQLIRLHNNNKETLIGSTAYLTGFGIIDDYYHQATRLRKAILHIDSPTKCLMNSAESPEICCTSTISEGKACKGDSGGPLTILRNGKYIQVGITSHLSILPLCRISFNNSVYTRVSAYIAWISRVTGIDFSKFNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8U0</accession>
    <name>A0A6P7G8U0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Probable multidrug resistance-associated protein lethal(2)03659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114339177</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145606.1">
        <property type="nucleotide sequence ID" value="XM_028289805.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504602.1">
        <property type="nucleotide sequence ID" value="XM_050648645.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648645.1">
        <property type="protein sequence ID" value="XP_050504602.1"/>
        <property type="gene ID" value="LOC114339177"/>
    </dbReference>
    <dbReference type="GeneID" id="114339177"/>
    <dbReference type="KEGG" id="dvv:114339177"/>
    <dbReference type="InParanoid" id="A0A6P7G8U0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="837"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1046"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="95"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="413"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="837"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028145606.1"/>
        </source>
    </evidence>
    <sequence length="1373" mass="153394" checksum="B722E27026B93E28" modified="2020-12-02" version="1">MDSTEVQNNPNPRETAGILSIMFFGFTIPTFRTGMKKQIGVEDVYNTLRSDRSEYLGDRLEKNWNRELELVKQNKKEKPSLFKAVVRTFWLEYLLIGIIAAVSDIGIRSFQPSMLGGVLDYYTPGSKKSKLEAYFYGSGMVIMSLTSSILMNQYMTNAAHAGMKVRSSVCALIYRKATRLSRTALGDTPAGKVVNLLSNDVARFDFASMMIHQLWIGPVSTIPVIYFLYQRAQLPGIAGILVILIMSPLQATSAKLATKFRKMTALRTDERIRLMDEVILGIQVIKMYAWEIPFQKVIGLARKAEIKIIKKNSYIRALFMTLGMVTTKLALFATLVTITLTGGEITAAKVFVLISYFNMLSMTLTGILTRGIAEIAEMFTSIARLQKFLENDEYKYDQNKISSDPNENSKSMLSLKNIYAKWDASLSDCVLNDITLELNKGKLLGVIGPVGAGKSSLLQTLLGELDIDKGSINANGTYSYASQEPWIFSSTIRQNILFGADYDRKRYKEVIRVCALERDLEQFKDRDMTVVGDKGASLSGGQKARINLARAVYREKDIYLLDDPLSAVDIHVSKVLYDECINGFLKNKTRVLVTHQVHYLKNASHIIILNNGRIEGEGSFNDLANSDNLYAQLLTKEPEITEEEKVKQIEFARQVSRQSRKSRKSSMTSIISEKTIVEGLMEDSDEDSEDEENTKKLEMRDMQEESSKGKVLGSLLLRYFRTGANCFNVFLILSLYVLVQVSSSMVDYFLSIWTNIEDERTSASILLESNSSSTLLEDISTTIASNNINSTVVLADFPSTIPSTTLSDAALNTLNTTVKLEPQAWIQFPAWTTEECLYIYGILISISILMTLGRSFSFYSLVMSCSRNLHQILFKGVIYAKMRFFDTNPSGRVLNRFAKDIGSVDESIPRVLLDGGQMILQIFGSLILVGVANPYAIAMALILAIAAFFLRNIYLKTSKNLKRVEGILKSPVFTHLSATLQGLPTIRALRTEKILQAEFDKIQNYHISAGFMNFTCGAAFGISLSMCSNIFIAVLIFSILTFDKAMGLTGGTVGLAVSQASTLTGMIQMAMRMTADISNQMMSVERVLEYEQLPPEPQPKNPKPLPKNWPSSGKIDFQNVKLQYFEGGPTIIKDLSLNVKATEKVGIVGRTGAGKSSLIAALFRLANVEGKIAIDDIDTRDIYLRDLRSKISIIPQDPVLFSGTLRYNLDPFEEYSDEQLYKVLDEVELKDPNNIINRLENRVMDRGSNYSVGQRQLICLARAIIRNNRILMLDEATANVDPQTDALIQKTIRTKFANCTVLTVAHRLNTIMDSDKVLVMDQGTAAEFDHPHLLLQNSNGIFSKMVEDTGPGTCEQLKTVAKNTFDKNLLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNC1</accession>
    <name>A0A6P7GNC1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114344498</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151134.1">
        <property type="nucleotide sequence ID" value="XM_028295333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNC1"/>
    <dbReference type="FunCoup" id="A0A6P7GNC1">
        <property type="interactions" value="1422"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648371.1">
        <property type="protein sequence ID" value="XP_050504328.1"/>
        <property type="gene ID" value="LOC126883126"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNC1"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="13">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028151134.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22436" checksum="846CFE1C083E1FA6" modified="2020-12-02" version="1">MVNGRIPSVHSKTYVTPRRPYEKARLDQELKIIGAFGLRNKREVWRVKYTLAKIRKAARELLTLEEKEPKRLFEGNALLRRLVRIGVLDENRMKLDYVLGLKIEDFLERRLQTQVFKSGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLKSPLGGGRPGRVKRKNLTKKSGGGGAAEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GUP0</accession>
    <name>A0A6P7GUP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114346925</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028153466.1">
        <property type="nucleotide sequence ID" value="XM_028297665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GUP0"/>
    <dbReference type="FunCoup" id="A0A6P7GUP0">
        <property type="interactions" value="1047"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645472.1">
        <property type="protein sequence ID" value="XP_050501429.1"/>
        <property type="gene ID" value="LOC126881281"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GUP0"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028153466.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21247" checksum="C722903314A19BD2" modified="2020-12-02" version="1">MGDITNPPISNEDILKLCKPATEETKDFIMQQTMYRIKNPKISIPFYTEVLGMQLLTKLDFPSMKFSLYFMGYEDPKDLAGGLSSQERVTWTFGRKATIELTHNWGTEDDENYKPHNGNQDPRGFGHIGVMVPDVYKACERFEKLNVNFVKRPDDGKMKGLAFITDPDGYWIEIFNNKSVGDTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GWA4</accession>
    <name>A0A6P7GWA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114347540</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114347540</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154031.1">
        <property type="nucleotide sequence ID" value="XM_028298230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GWA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656903.1">
        <property type="protein sequence ID" value="XP_050512860.1"/>
        <property type="gene ID" value="LOC126888556"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GWA4"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="75"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028154031.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29101" checksum="0557640C68DCC820" modified="2020-12-02" version="1">MANFECFVQQYPLIFNNSDIPDSWKPLLGSVFSCSQCPTVFDQMLLGNPLDNIALALKDDFDWFPKSDTLWSFTKLCRPEDVKVVIVGQDPSDASATGLAFSKDVGEGIYQSTETILEEVRNDIGEHNLRPFPEDYGNLDYWAKQGVLLLNSALTKSPHKSHLEIGWKTIVAELIKQLQQINKNIVFVFWGWHAMLLSHNVEYDDWNKLVTGHPSKNNEKNDFLGCRHFSNANRRLIKYGIEPIDWCPLPPKNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H9A0</accession>
    <name>A0A6P7H9A0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114345870</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="RefSeq" id="XP_028152485.1">
        <property type="nucleotide sequence ID" value="XM_028296684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H9A0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028296684.2">
        <property type="protein sequence ID" value="XP_028152485.1"/>
        <property type="gene ID" value="LOC114345870"/>
    </dbReference>
    <dbReference type="GeneID" id="114345870"/>
    <dbReference type="KEGG" id="dvv:114345870"/>
    <dbReference type="CTD" id="115886423"/>
    <dbReference type="InParanoid" id="A0A6P7H9A0"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028152485.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="46442" checksum="286E9EA4C0D8DBD9" modified="2020-12-02" version="1">MVHYNSLINMETDKLPAETKPSVQESPPKPKVGTGLKRTITGLSMLAGFGLVVYGGVPCITLTGFFIQFKCFQEIIKIAYQIKKIPDVPFFRTINWYFVITANYILFGELLAKYTQVFIKKYYLLQVLARYHRFMSFIWYFIGIIWFLTMLKKKLIRQQFSLLFWTHFLVMIVSVQLYMTYQNMYEGLIWLIIPLWLVILNDVFAYVFGKFFGKTPLISLSPNKTLEGFVLGGLSTFILGSILAWIFCHFQYLVCPIKYIEVEDNIVASTNCTRSYLFEPSPYYIGNTGLSINYYPFIQHSLFMSVFASIIAPFGGFAASGFKRANKVKDFGDLIPGHGGIMDRFDCQFLMMTFVNVYISTFIKTPDVDLVFQQILNLNENAQLEFYKLLKDSLHERLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICA5</accession>
    <name>A0ABM5ICA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129692.2">
        <property type="nucleotide sequence ID" value="XM_028273891.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273891.2">
        <property type="protein sequence ID" value="XP_028129692.2"/>
        <property type="gene ID" value="LOC114325755"/>
    </dbReference>
    <dbReference type="GeneID" id="114325755"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045942306" evidence="1">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129692.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="104" mass="11105" checksum="6ABE12450D940EDF" modified="2025-10-08" version="1">MKSLALVTIVFFAVYQAVSSDGPLCENPDTCANQKCTENLVCSDSQILVHNGGICGCCDDCYLKLYEGQACTKSSPLAFGRKNPKEKCADGLVCKQGKCAKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICH7</accession>
    <name>A0ABM5ICH7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myogenesis-regulating glycosidase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129813.2">
        <property type="nucleotide sequence ID" value="XM_028274012.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274012.2">
        <property type="protein sequence ID" value="XP_028129813.2"/>
        <property type="gene ID" value="LOC114325880"/>
    </dbReference>
    <dbReference type="GeneID" id="114325880"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="256"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="563"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129813.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="73444" checksum="5DCE60E91694F9D4" modified="2025-10-08" version="1">MKCTTTSSAVYSIIKGMNCWRAILIAILLVGVNQVLVQCSTVNEIILKPSSNGLAIEVNQKEEKKLKGTIGVGIDFTNINCYGQESCQVGDADFSVKQSEDGFHIKWETNNLTSVFQDCFDFEEGVHWYGGPERKKQSWPIEKLEIESYQAYVLHQLDNFAVAERYWLNSKGLYIYLNSKVPLYVDQNISNKNRVCFIAKLEGPYINRHKNFLEYDIVIKDDPREAHVHAVKTFLGKPSGYPDERMITEPIWTTWAKYKTKISDEIVLDFAKDIRDNGYEKGQIEIDDYWEKCYGAQEFTPTTFPDITNTIKTLKSWSYRVTLWIHPFVNSDCQDNSKIGLEKGYFVLDQNGRANGSWWNGNDSYQIDFTNSEAAEWWSARLKKLQQNPGIDSFKFDAGETDYSPQPSVYHGVNQEDVPNILSESYVRTCAKFGPLVEVRSGSRTQDLPIFIRMIDKDSNWGDSNGLYTLITTLLQMNINGYTLVLPDMIGGNGYAGKLPDAELLVRWTQANTFMPAMQFSYLPWEITSTKFNVAKIVKKFVDLHEKYADHIIRAMKNSVEKGSPVNPPIWWIAPKDVQALGCDDEYLVGEEILVAPVIKEGATSRDVYLPAGKWVDGNNGDIYQGPVTVDYDAGIDILPFFILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFW3</accession>
    <name>A0ABM5IFW3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Equilibrative nucleoside transporter 3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131827.2">
        <property type="nucleotide sequence ID" value="XM_028276026.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276026.2">
        <property type="protein sequence ID" value="XP_028131827.2"/>
        <property type="gene ID" value="LOC114327415"/>
    </dbReference>
    <dbReference type="GeneID" id="114327415"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131827.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48966" checksum="EE711DD0D78E2839" modified="2025-10-08" version="1">MSCYFDFIAFIKRRLVYPKVCGPSGHAEFAIAYKKNAMETDKFYLAHIVFLVFGIMHLLPVSFFVTANDYWMYKFRNTTSDNTDPNYRSILQSNFASGTNVAQSVPTVICMVLAVVFAYKIKVKIRILTSLYVLATCFVVSTVFIKSDTDGWQTGFFALTMAILAVMNGILALFQVSSLALLAKFPPIYMKTFLTGQGIGGIFCSALQVLALVIGTSSEAAALIYFLCGTILTTATLMLYHFIQQQGFYRSVTGTSIEDTKKDLITLSEVKEISSKIWTSLVIVTAGALAYVPTHPSVAALVVSEYKTDFTKKYFAAVVTFLFSDICCLIGRGLATATNKRPRPSVLALLSVVRMVIFVPLFIFCNALPRKHLHVLFPHDWQYVLILGSFMISSGYFFNVAFLNVIKLAPEEEENAYLIMQTVIGITGAVFSPLGVLCVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IID4</accession>
    <name>A0ABM5IID4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chymotrypsin inhibitor-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133501.2">
        <property type="nucleotide sequence ID" value="XM_028277700.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277700.2">
        <property type="protein sequence ID" value="XP_028133501.2"/>
        <property type="gene ID" value="LOC114328748"/>
    </dbReference>
    <dbReference type="GeneID" id="114328748"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045196278" description="Chymotrypsin inhibitor-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9238" checksum="F4028095843FAB56" modified="2025-10-08" version="1">MKTIMILCAFVIFVIVQIQCQEDGCGPHERRVECKSCCKVPTCQQKVPPKCNRICLQVCFPGCECLPGYIRLRENGPCVKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIT0</accession>
    <name>A0ABM5IIT0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133790.2">
        <property type="nucleotide sequence ID" value="XM_028277989.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277989.2">
        <property type="protein sequence ID" value="XP_028133790.2"/>
        <property type="gene ID" value="LOC114328986"/>
    </dbReference>
    <dbReference type="GeneID" id="114328986"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133790.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="285" mass="33514" checksum="B4F62F17E330C9D0" modified="2025-10-08" version="1">MDTELNNESDAELSELEDNNEEIPNQIEESADSSDSEKSADDIDFVIDKEGVPDSTQEKSEKEKLLDEIFKDCPISFKEKKPKVKKIKKNSFIRQTLADLGFNDDGTLRSKPHHKQKKLLTKNQRDEVKKALKKSVITPEFEKLHVVPPLDVSEKKLKEQRKKERSLTKGSKWYGLPATELTDEVKRDLEVLQMRSVLDPKHFYKKNDLKVLPKYFQVGKVMDSPLDYYNNRLTKKERKKTLVDELLADAEFNKYNKRKYKEIITEKQQTHYKAWRQAKRLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IM04</accession>
    <name>A0ABM5IM04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136075.2">
        <property type="nucleotide sequence ID" value="XM_028280274.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280274.2">
        <property type="protein sequence ID" value="XP_028136075.2"/>
        <property type="gene ID" value="LOC114330851"/>
    </dbReference>
    <dbReference type="GeneID" id="114330851"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF87">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136075.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="481" mass="53855" checksum="1C4C10A82351BF1C" modified="2025-10-08" version="1">MKSFPPIIQPILPLEDKEINNNDNETNRHKFKDTSIPVHRLNKKSKNHQHIHKLLISSNLIFDFHSDLKVIRSTMYEPVLDRCVTSTIIKPSRHPTDDFLINEYGENNDLEPPPPERPPRRHGKISKQNGSQETNAYLSPVKMRPSNGDTTTIDVDHMKLTNNKNKKVDASVQTLHIVPYRLRFVPGTDCDVKLSPSEKSCALKLACCCRLLSQWILSQIGLSMILVVWALLGAYAFYNTEGPRELRQAETLAKIQRDLSVDLAIDLKMTEDHQEAWSNKIHKYFERHEKVFLEAVGAGFGEGGGGNIWTYPGCVLFAVSLLTTLGFGAPVPRTPLGRGTAVLFAAIGIPLHFLLILNMGNLYAIRLQQLAYRNSLTEIPSTPKPKWLQYFPFLSIVVYYILGVILFGVLRQRDAISCLMFPLDFTAAGGVANVEGHIRILYALYLEMAVTLAATIVSLFQASASRGIVDIGLRLGLLTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INB2</accession>
    <name>A0ABM5INB2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Regucalcin</fullName>
            <ecNumber evidence="8">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028137185.2">
        <property type="nucleotide sequence ID" value="XM_028281384.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281384.2">
        <property type="protein sequence ID" value="XP_028137185.2"/>
        <property type="gene ID" value="LOC114331750"/>
    </dbReference>
    <dbReference type="GeneID" id="114331750"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045821874" description="Regucalcin" evidence="15">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="33"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137185.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="339" mass="36936" checksum="E73379520D5EE978" modified="2025-10-08" version="1">MWRFLCLVFVIFRVGSADLGPCVHQVTSPVGHAEGPHWDARRNILYFVNIPDGEVYAYHYNSKILKKITLSGTASPVVPSRKDPNLLIVGVNRSVVAVEWDGKNKLGGQQVLTTLSHQFPGSRLNDGKADKQGRLWWGTIGPEVNLVVASDQGLFYTITRENLNDPKVAVQPVTNSNGLAWNKANNKLYYIDTPTLKVVSFDYHDGNGTISSTNQTVFDLRSTHNVTGLPDGMTIDTEDNLYIALFGGGSVIKVNPATGKLLKVIAIPARDVSSVMWGGPNLDILFVTTSDRNLSPSERIQYPAAGSVFAVTGLKAKGFEAHTADIIDELPKQKECGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZW7</accession>
    <name>A0ABM5IZW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TELO2-interacting protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154357.2">
        <property type="nucleotide sequence ID" value="XM_028298556.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298556.2">
        <property type="protein sequence ID" value="XP_028154357.2"/>
        <property type="gene ID" value="LOC114347902"/>
    </dbReference>
    <dbReference type="GeneID" id="114347902"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24176">
        <property type="entry name" value="TPR_TTI1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="354"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="725"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154357.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="119417" checksum="D437B6B29358698C" modified="2025-10-08" version="1">MEETYPDFETFYRFKIACQRMVENPNDETNLEQLNKLVKNASKNCIKVVQPTVLASFYPIIKAISVEDTRFGSKFIHKLIDTLTDVFEKSIIDKMGIFFNMYSLLLYVIYDSRENRVLPIPEEMKLSVMLCTKALARSVSTDLLPELYNKVNAPKLCQMIYVALELAKFEKLRSLRIAAMECIMCIAQVFDDENFHDIVLRRQLAEVFMFFLPGIASGILKILLEDSKVGSKVQAVALKTWGRIVTLVMQNYDATSSVPNIVEFTRSVKNDYSKDKDTPIKKCTNNAEVTEYIETTKLNKKFYVSTDQKLQMVVKDFYKVLHCADEQVRLELLNMCQIIMNNCLGTMPLSSSHLIEIVISLTEDADKEVSKKSTQILSDLSNLLSSESLKAFIEGLEEGFITDINALPRRFNSIDEKEQLASLNLLIGYLNLFGEHKLQQVLLSANYLDTLLTTLLYICELEKCDIGLVEEYTTKDLHYVQAVTQPWMKFTRFKENTTLYQVQKLCSLLGKYGTFRLVSDFLLDVIMYNEVNRKEAIFILNEVISGINNDKEGVDIIANIFETYIDDKYYQVPLEVSEDVNRNEVLQNIIQVCLLTEGIGKIALKLKQGFHQFMLKILFIVLEKTGSSYEYIKIAGLKTLHDITSACGYSDFNDLITSNIDYLTYHIERKLKSALKENREHALDVLTVLLQYCTAEILEHLKYIINTVIDSFNDFGININSYLQVFKVTVQVINRWWPVEIIDEDIKPKAEKIKEVEDFKVTGADKVEDNFSDEIMGKTAEEMYEEDRLKKEEQLKMDTEEVEEEEYKKPDPPTRIKITVSILKQSLHFLPSSIKSRKILVLDILTDGIEIIKDYEDELLPIVHLIWSPLVSRFDETGLPVVMTLSFKLLMVLARVSKEFIRMRTTKEVLPKILKFMNDLSKDSHLKDRGAQYRYSQNYKFQQIVLRNLAKVLIYLDVADEHVHKTMDCFRLYLSDKQPKALQDAALHFFVCMARYDPPTVVNKINSWEKEDCDGNIKTMLLDTLNHKQTGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJS0</accession>
    <name>A0ABM5JJS0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498183.1">
        <property type="nucleotide sequence ID" value="XM_050642226.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642226.1">
        <property type="protein sequence ID" value="XP_050498183.1"/>
        <property type="gene ID" value="LOC126879183"/>
    </dbReference>
    <dbReference type="GeneID" id="126879183"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="582" mass="68823" checksum="DFD9BEEA6A763415" modified="2025-10-08" version="1">MKSPIVILRFGCKIVTVNCIEINKIKSNQMEVKQEISDETCKVEVEYKDLDYDAFLDGFKCEIKDESNTQSTHDTHDYLDVKEHLINTKIEHHEDIHPFDQKTEKGCLQDEPKMETTNTPIEDSSNDGNYMSQRYKEKTFNKNKKVGSRQRHYKCEICFKQFSQVCNLKTHLKVHTGEKPYTCDICFKKFSQANPLERHLRVHTGEKSHKCEICFKQFSQQVHLKTHLMVHTGEKPYTCDICFKKFSQANLLKRHLRVHTGEKSHKCEICFKQFARKDHLKIHLRVHTGEKPYKCEICFKQFAQKDHLKIHLRVHTGEKPYKCEICFKQFTTEPGLKYHLRKHTEEKPYKCEICLKQLITAQDLKYHLSTHTGEKSHKCEICFKQFSQKGHLKIHLRVHTGEKPYKCEICFKQVMTAHGLKEHLRVHTGEKPRKCEICFKQFGRASILKEHLKIHSGEKPHKCEICFKQFAQKHHLKIHLTVHTGEKPHKCEICFKQFAQKDHLKIHLRVHTVEKPYKCEICFKQFTTEHGLKYHLRKHTEEKPYKCEICLKQLITAQGLKYHLSTHTGEKSHTSVKFVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJU7</accession>
    <name>A0ABM5JJU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050498212.1">
        <property type="nucleotide sequence ID" value="XM_050642255.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642255.1">
        <property type="protein sequence ID" value="XP_050498212.1"/>
        <property type="gene ID" value="LOC126879202"/>
    </dbReference>
    <dbReference type="GeneID" id="126879202"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="454"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="783"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1235" mass="140423" checksum="A4B14055050E887C" modified="2025-10-08" version="1">MNKFLVTKDTFKKIRKFGLQGRTLEFKIRDVPQSEEPVGWVKKAIEEIVLKGTEGLEPTDQVGFTFCSKDFARGQGWMRFKPACEVTVDDIWDKISSIYQSNSTGLNTETFCLGITTVKLPAGKGGPRGRAYNSFNEECLKRRGTVVIKNKDNLCLPRALVVAKAHVDKDQEWKKVRQDIGKIQGQRAHQLIEAANVTIPVGGAGIPELQQFQGHLTDYKIVVYSYGSKGRDVMFCGNTNGPALNLLYHEGHFNVITSLTAAFCCIYYCEECHQPFNNKNDHRCGGTCFACRRSPACSKDCVKIPCDQCGRNFYGKACFNAHLGSVCDKIKRCRTCYKIYTKSHVCGEVFCKTCKKNCPSDHLCYIQPDSGLPPSSDFLFIFYDLETSQEKILADGSLLQEPNLCVFNQRCYKCLPEMKLVFCQSCGFRQKILRGLDVISLFMNHILQIRKKFKNVVVLAHNGGGFDHQFILNYILTKTDLTPDLIMRGTKLVSMAVGNARFLDSLNYFPMALSALPKAFGLTELKKGYFPHLFNREENQSYVGPMPDLKFYDPDNLKDDARDKLIAWHAERVDEGYVFDFQKEIVEYCISDVEILTKACLTFRKQLMDTSNVCPFFEATTVASTCNKVFRRNFLQPNTIALIPKGGYRFKDNQSKIALQWLLWEEKQRCIKIQHAARGPEALIGNCRVDGLYENTIFDFQGCYYHGCPTCYPTDRTAPLHDDPSDCMENRHDKTIAKVKHLRSIGYEVVEIWECQFRKMLTAEIKAYTEGHPLMASLPLNPRDALYGGRTGNTVEYYKCKDGEKIKYVDVCSLYPWVCKYGKFPIGHPKKIYIGQECTAVDITELSGLIKCKVLPPTNLYHPVLPTKMNSKCMFVLCRKCGEDFAEEECEHSNDERALTGTWVIEEVVKALSKGYKIIETYEIWSYDTLQLSKSQKGLFSDMMNKFIKVKQQASGWPRGCVSDEEKSRYIEEFLQREDVRLEFSDITENPGLRSLAKLMLNSFWGKFAQRENLPKTSIINKPGEFFAMLINPSIQVNTVIPVNEDTLVVTWEYVKEAYSMSSAVNVVLASYVTALARLKLYSYLEIIGSRAKYYDTDSSIYLSKAGLPDLPIGECIGDLTDELGGGYISEFVSGGPKNYAYKYTLPNGEEKICCKVKGICLNYEASKLVNFDTIKKMVLMKSDPVSVVTKQIQRTQDHCVITKTLEKKYRPNSAKRKFFEDFTSVPYGYKKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNM6</accession>
    <name>A0ABM5JNM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499539.1">
        <property type="nucleotide sequence ID" value="XM_050643582.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499540.1">
        <property type="nucleotide sequence ID" value="XM_050643583.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499541.1">
        <property type="nucleotide sequence ID" value="XM_050643584.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643582.1">
        <property type="protein sequence ID" value="XP_050499539.1"/>
        <property type="gene ID" value="LOC114329640"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643583.1">
        <property type="protein sequence ID" value="XP_050499540.1"/>
        <property type="gene ID" value="LOC114329640"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643584.1">
        <property type="protein sequence ID" value="XP_050499541.1"/>
        <property type="gene ID" value="LOC114329640"/>
    </dbReference>
    <dbReference type="GeneID" id="114329640"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="82517" checksum="301EF23532F3F08C" modified="2025-10-08" version="1">MEFWRKRNGLKGNLVHPDRQNKKLSATAQRRMLIEEMLAANGSLFSETDKKILTSLVGDQNQPKEWVNPMFKNTVYSDNESREVHGDLPCNFNEDRNARWDQWDESGAEKPKTSFLSSFSDQDPPENRNQRNQFRGETQGVNLFNPQRSSFIQERSPGQDPPENRNQRNQFRGETQGVNLFNPQRSSFIQERSPGQDPPENRNQRNQFRGETQGVNLFNLQRSSFIQERNPLNSERSSLDNNLSDAQRRRMVIEEILAANSSSFSEAHKKTLNSHFSVEDCVRGPFKNTAYSDKESRGVCGDLPYNFDEERRNQEDRNAKNVSGTSFWSNNRNERNEFLPETRDVSPFNPQRGPLIPERSPLNPERSSLEQYGSSNNQQAKSVSGSSFWSKSRFERNEFRPETRDISPVNPQRNPIIPERSTLNFKRGSLEQYGSPNNQEAKNVSGSSFWSENRFEKNQLSPKTRDVSPKVNPQRSLFIPETNPLNRERSSLEQYGSSNNQQQRNQFRFETREVSLLNPRRSPFIRERNPLNSERNSLEQYGSSSNQQDTRHISVDRRTLLDEIIDFEAPQDNSGNGIAPLMTQSTQDDSGNNIEILDFKPPQDNSGNGIAPSKVYNYGPIPKGCVRVKMWIDKSISFSDPLHILRQLSQQNSCLRTKSWTVLDVKNNPKTGFIFLVQLRQEHLTVLRSFNMAPCIQKKKTLFKVLQPGEELNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQD6</accession>
    <name>A0ABM5JQD6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500152.1">
        <property type="nucleotide sequence ID" value="XM_050644195.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644195.1">
        <property type="protein sequence ID" value="XP_050500152.1"/>
        <property type="gene ID" value="LOC114335442"/>
    </dbReference>
    <dbReference type="GeneID" id="114335442"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="161"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="589"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="881" mass="100305" checksum="246C14D99AE1523E" modified="2025-10-08" version="1">MENDVGEWDVRDGFSRYNQLILSTNRSNIMGVNLNISYVVTNNDTFNHLEDFRDRHIDPISKVNWFVMRNLLLLLNGTSTPIFQSTWGYRDGNTSRYTGMVGDLKSGEAEIGGTAAFFTIDRIDIIEYIAPSAPTHIRFLFRAPPLSYVSNVFTLPFDSYVWYCCFGLIPLVFIAVYIIVKWEWYDPVFKETVAETHSNTIMPLRPGFFDVLVMELGAITQQGTDTEPKSVSGRIATVFTFIAFMFLYTAYAANIVAILQSTTESIKTLEDLLHSRISLGVEDIVYAHYYFQTAEEPVRKAIYHQKVAPKGQKANFMDIYEGISKVQKGFFAFHVELSSGYKVIADTFQENEKCGLKTIEFMNMLEPWVSIRKRSAYKEVIKVGLRKILEVGVQRRDVNRFYSNKPVCQNKGSNFGSAGLVDCYAAFLIYGIGIIFSVFLMVIEILVQKRLRKRKSSAQSDVYVSPVEEYLYKETHLFFYRNIHIDAISKLNWIIVGLLLSTLNASSTNIFQPTWGYREGNSTIYSGMIGDLQTNRAEIGGTASFFTLDRLDVIEYVAPSAPTFMKFIFKAPPLSYVSNVFTLPFDTYVWYCCFALVPIIFIAVFIIVKWEWKDPVFKLKVEETHSNSITPLRPGLFDILVMELGAITQQGSDTEPKSNAGRAAIVFTFIAFMFLYTAYSANIVALLQSTTESIKTLEDLLHSRINLGVEDIVYAHYYFKTADEPTRKAIYQQKVAPKGQKPNFFTKEEGIARVQKEFFGFHIELSTGYKVIADTFNENEKCGLKEIEFIKLLEPWLSIKKNSAYKEVIKVGLRKILESGLQRRNTNRLYLKKPVCHSKGSNFGSAGIIDCYAAFLIFGIGIVLSILFCLAELIVQHKFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQR5</accession>
    <name>A0ABM5JQR5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500280.1">
        <property type="nucleotide sequence ID" value="XM_050644323.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644323.1">
        <property type="protein sequence ID" value="XP_050500280.1"/>
        <property type="gene ID" value="LOC126880459"/>
    </dbReference>
    <dbReference type="GeneID" id="126880459"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="54193" checksum="B00F07EC70391140" modified="2025-10-08" version="1">MTGIHINFQNCRGLNTKTAEFYKNCLEGNYDVVVAVETWLREDMVDGELIDINVFNLLRSDRNQEISGKTKGGGVLMVIKKEHKILKVTQHCSSFEILVADLKINNKLSIKLIGVYIPPDCKLHDYANCFELLQTHITDINNTFIFGDFNIAEIKGTENLDFTNGSAKFKSMIEFLNFNSFLLYNNVKNWQGKTLDQVVASVDNINSCKVCQEQLPLVKEDRLHPSLEIQLSFTVSSFRQTDKLVGNRFNFKKANFDLMCDLMRNMTWEAVTEEIEVDKALDIFYAKVLNIFEGSVPQYNIYKNYSNFPKWFTPDIKKLLKQKNNFRKLRHVSIYFNNQFIETRKKLKSLINIEHRKYIRQIEENIENEFNNFWNFINNKNSKSNQTEIFYFGGKEINQSDTANEFAKYFESVYSTDISSYNTNFTNIISNNNVLNLPSITSVDYDNAVKKLKPKKAAGIDGIPRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRZ5</accession>
    <name>A0ABM5JRZ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500700.1">
        <property type="nucleotide sequence ID" value="XM_050644743.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644743.1">
        <property type="protein sequence ID" value="XP_050500700.1"/>
        <property type="gene ID" value="LOC126880703"/>
    </dbReference>
    <dbReference type="GeneID" id="126880703"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21555" checksum="4215AADBA900AF1C" modified="2025-10-08" version="1">MDETYVHSSHTYLKSWSDSSNKGIQKPVSKGQMLVIVHAGGESGFVKNAYLCYKPTIKTGDYHDTMNYDNYKKWLQDKLIPNLPPNSVLVIDNAPYHNVQTEKCPTMSSRKAEMQQWLTTRNISFTDDMLKFELYDIIKLHKPLFKTYEVDKILEDKGHSVLRLPKILSGFESYRVSMGFYEAICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSK7</accession>
    <name>A0ABM5JSK7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500910.1">
        <property type="nucleotide sequence ID" value="XM_050644953.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644953.1">
        <property type="protein sequence ID" value="XP_050500910.1"/>
        <property type="gene ID" value="LOC126880881"/>
    </dbReference>
    <dbReference type="GeneID" id="126880881"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="433" mass="49755" checksum="D6D68E464A9EB381" modified="2025-10-08" version="1">MLSKKLLKKLKPKKAAGTDGIPPYVLKGCNRLNPDVIRSGFRACGIFPWNSSALDYSKCLGKEFETEDNLDEHNDLPTLIDPNTTISYKQFCEIVGNDKIKQLCRNNCKTQSDDYQILKQIFSAFTEKSSVEISTKDEQEKILEEEVEFLDTSEVIFDINDIPVIIDDTEIVNIPEMENKTLIVPENEIFNMQGIEEYTNEAESSVTKTVKEDQKTKKPEKSLNISENISVNATNKSIATYLIWPDTPARKGKKQTQKLPFVLTSSDRRKIVKEKMEKKLEEERKKEQRKLERKEKQSIKENQKKIKSSNNKKPKKLAKTFNKSEEKSRQPIEMISTKLKKGVKVHFPIEKYPEKTKKALKVFSPLNHESRSNNTAVFEPPLPEFVKVPTPEFHSHTKSSSSVNNQDNLDIFKHSPTPEANLRLSPKIFSRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSX0</accession>
    <name>A0ABM5JSX0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501037.1">
        <property type="nucleotide sequence ID" value="XM_050645080.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645080.1">
        <property type="protein sequence ID" value="XP_050501037.1"/>
        <property type="gene ID" value="LOC126881066"/>
    </dbReference>
    <dbReference type="GeneID" id="126881066"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="639" mass="74684" checksum="49D58B7F855D8495" modified="2025-10-08" version="1">MEVKQEIIEETCKIEIEYNDLDLDDALLDVFKCEVKEESNTNEIEPHGSNLSTSFEENQKTEKDYLQENKMEILEAQTENSSHEGNCTNAHAEGKTLNKNKKGVNGKRAYKCEICFKHFSEAGSLKRHLRVHTGEKPHKCEICFKQFTTTSHLKQHLRVHTGEKPYKCEICLKQFSEAGSLKTHLRVHTGEKPYKCEICFKQFSEAGSLKTHLRVHTGEKPYKCEICFKQFSEAGTLKRHVRVHTGEKLHKCEICFKLFIEAVQLKIHLRVHTGEKPYKCEICFKQFTTASSLKKHLIVHTGEKSYKCEICFKQFLRVNQLKIHLRVHTGEKPHKCEVCFKQFTATRSLKEHLRVHTGEKPHKCEICFKQFIRVSSLKVHLRVHTGEKPHKCEICFKQFSEAGSLKSHLRVHTKEKPYKCEICFKQFSEAGSVKMHLRVHTGEKPHKCEICFKQFIHISHLKKHLRVHTGEKPYKCEICFKHFRSDLKRHLRVHTGEKLHKCEICLKLFSQAYSLKEHLRVHTGEKPYKCEICLKQFIQATNLKTHVRAAHTGEKPKCEICFKQFSEAGTLKRHLSVHTGERPYKCEICFKRFIQAAHLNQHLRVHTGEKPHKCEICSKEFAKTYSLKQHLRLHTVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU37</accession>
    <name>A0ABM5JU37_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 2</fullName>
            <ecNumber evidence="5">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphoribosyl pyrophosphate synthase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050501450.1">
        <property type="nucleotide sequence ID" value="XM_050645493.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645493.1">
        <property type="protein sequence ID" value="XP_050501450.1"/>
        <property type="gene ID" value="LOC126881297"/>
    </dbReference>
    <dbReference type="GeneID" id="126881297"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="17">
        <location>
            <begin position="56"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="370" mass="40793" checksum="6B60E0CAFE5CFFF1" modified="2025-10-08" version="1">MRNLAFRIAQQQRNKQVFAIFVSGRTLTFLSSKRMPVSKEPSTLPSAKLLRIMPNIKVFSGTSHQELTQRIVDFLGIELGKVETKKFSNLETCVEINESVRGEDVYIVQSGSGNVNDNLMELLIMIHACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMIAVAGADQIITMDLHASQIQGFFDIPVDNLYAEPAVLAWIKQHIVDWKNSIIVSPDAGGVKRVTSIADKLNVEFALIHKERKRANEIASMVLVGDVRDKIAILVDDMADTCGTICTAADKLMNAGANKVYAILTHGILSGPALSRIEAAPFEQVVVTNTIPQEENMKICSKLECIDISRIFGEAVRRTHNGESVSYLFCNVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUL4</accession>
    <name>A0ABM5JUL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050501628.1">
        <property type="nucleotide sequence ID" value="XM_050645671.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645671.1">
        <property type="protein sequence ID" value="XP_050501628.1"/>
        <property type="gene ID" value="LOC126881408"/>
    </dbReference>
    <dbReference type="GeneID" id="126881408"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF234">
        <property type="entry name" value="ZINC FINGER PROTEIN 281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="598" mass="70466" checksum="954CC95053127D3D" modified="2025-10-08" version="1">MEVKQEISEETCKVEIEYNDLDDTLLDGVKCEIKEESNRQRTHDTSDYLDLKHAINTKIEQHGNKLDSFEENKKTEIGYLQQVDNKMEIMETLIEHSSSEGNFMGPHAEEKSLNQNKKVATGRRPYKCEICFKQFNRADRFKTHLKVHTRKKPHKCEICLKQCISAGHLKTHLRVHTGKKSFKCEICFKQFSEASNLKTHLRVHTGEKPYKCEICFKQFTQAVHLETHSRVHTGEKPYKCEICFKQFSEGGSLKTHLRLHTGEKPYKCEICFKQFNEASTLKTHWRAHTGEKPYKCEICFKQFSQLGGMKQHMRIHTGEKHYQCEICFKQFNNGSALKRHLQVHTGEKPYKCEICFKQLTRAGDLKIHLRLHTGEKPYKCEICFEQFTRASNWKIHLRRVHTGENPFKCEICFKQFSEASNLKAHLRVHTGEKPYKCEICFKQFREASTLKRHLQVHTGEKTYKCEICFKQFIRADHFKTHLRIHTGEKPYKCEICSQRFSQAVSLKKHLKLHTGDKPYKCEICFKQFTIASHLKTHLRVHTDESYKCEICFKQFSRNGILKKHLKIHTGEKPYKCEICFKQFIESSDLKRHLKVHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUY8</accession>
    <name>A0ABM5JUY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501749.1">
        <property type="nucleotide sequence ID" value="XM_050645792.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645792.1">
        <property type="protein sequence ID" value="XP_050501749.1"/>
        <property type="gene ID" value="LOC126881500"/>
    </dbReference>
    <dbReference type="GeneID" id="126881500"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26333" checksum="B3401F5534B0F3D8" modified="2025-10-08" version="1">MGVAQSYVKRGRILLEFHESAIQKTLNKTNNELQKVIHVDCNTNAFDMMLKLIEKLPINRIVRNCNNGCPQRTRETNYYVLDNLLFKEALNEVEMQEALTADRDCSRRGCLGQSEVQYDSSGPIILIQLTDIRTLTHLDNIPIKFSDVLGTSDYYLLVGVIRYINNDLTSTNGLGKLSMGHYTTICRRNNLWTEFNDLNAGTQRTLTKDVDKKVNIEFLIYIKVEKTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVF1</accession>
    <name>A0ABM5JVF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501915.1">
        <property type="nucleotide sequence ID" value="XM_050645958.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645958.1">
        <property type="protein sequence ID" value="XP_050501915.1"/>
        <property type="gene ID" value="LOC126881596"/>
    </dbReference>
    <dbReference type="GeneID" id="126881596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="368" mass="42389" checksum="84BD7E07B45C0E1E" modified="2025-10-08" version="1">MDYIRDFDVQLEKDYYYAGETIKGNVVLDTIENFKLRTVRVILRGKAHAEWKVLVSGERRTVKDDQVFVDERHTIWGENNLDTTVPILPRGVHRFPFKFSLPESSLPCSFESRFCYIRYFFKVTVDIPYASPPQCIQYFTVVGPHIDCMEEQYLKPVALENRKSTCCWCCKKGTISLRCVIARTAYVCKESVKLKVSIDNQSDDEVKLRVKLEQVCEFFINKGVLGASKDLKHLIFEYGGCHVKPHAKSKWDSSNYLVIPPLPTTLVHICRLVQIYYLLTVYLDTDKDYNILQVSCPITIGTVPFRIPNSNKTQVIKYENACPVVEGGMYLAPEFLLGQVYDGNEHHLKDPLVLYKPVYVTVDKPDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JW49</accession>
    <name>A0ABM5JW49_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502165.1">
        <property type="nucleotide sequence ID" value="XM_050646208.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646208.1">
        <property type="protein sequence ID" value="XP_050502165.1"/>
        <property type="gene ID" value="LOC126881739"/>
    </dbReference>
    <dbReference type="GeneID" id="126881739"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="291" mass="33675" checksum="8596BB7931186B41" modified="2025-10-08" version="1">MAPVKDRVKKHREKTKKDPEKWEALKKKERERDKLRRLKKKEILKTNPQLQQQVRNKVNDRVKAHRERKKLLASAESTSKPTESPIGTYNSPRTFGKAVNKVKRSLPNSPHKKTAVLKKLVSDVIGIESLVSSTRKVKHAHVTAENRALVVEFFCRDDISRQTPGIKDVKTIRKKGEQKQKLQKRFMVMTVGEAYEEFKKRFPDVNIGKSNFFSWRPEHVCLVSDMPHDVCVCKIHFNFINLLESIHKGIPVIPRCHNELLKHLCCDPQNENCMYGTALPDVPLFAGRPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXW9</accession>
    <name>A0ABM5JXW9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502783.1">
        <property type="nucleotide sequence ID" value="XM_050646826.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646826.1">
        <property type="protein sequence ID" value="XP_050502783.1"/>
        <property type="gene ID" value="LOC114332615"/>
    </dbReference>
    <dbReference type="GeneID" id="114332615"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052651">
        <property type="entry name" value="WDR81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44662:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="297"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1598"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1894" mass="215767" checksum="07093FD1D0E4DFCA" modified="2025-10-08" version="1">MLDNFKEIGIPKKYLRKTNKEDRFAAVVSKLWIKHLIKHSKLTEFIEKPNFQAWPVTEEDVGPSWIKVLISCLPKRECKVFPLPKVRSSKDDAPFLFSQLMQYISQTNYNNLWKKAHKKYMSTDSHRETKITLTDYNAVLREIITRIYGCPIINSYDESLNVGQSAQFDVHLNIYPAVCAVETPKAIFLFHLPYMEYNISDCLTFSPAILEKSYTKSLFIIYQILNVLKSLHERSLTLGEITLKDIFISEDMWVYVFPQVTSNFFTSDSSTNKSNYECTNAPICNNYQYFSSHLYDKVQLKNESLSELCQLWINGWISNFTYISALNKLSGRVIGDPNCHYVFPWVTDFSSTCGKNWRDLKKSKYRLNKGDHQLDLTYDNSQSQIPHHVSDVLSPITYYVYMARTTPKSVLCKNVRTIWVPAEYPSSIQRIQEWTPDECIPEFYTDPSVFRSIHDDLDDLAVPSWASDPEEFIEIHRKALESPNVSEKLHYWIDLTFGYKLSGHPAVRARNVCLNLADDHENLTKSGLVQLFTHPHPLKAVDSPYFGKTPPKLFIGKLVKPRSRGRSNSSIQEPITSDEERYSYELPSRMLSRSRSSLYEEPPRSTRSSSTQRCEINNPNRVTEQAQGAVSDVIYLPKDYKPEFLLDSLEKRDHFFSKTFCRNYTDNIPNVKPDAQYALVQNAFTNMMFSENLDDRSRQRSPKLLQQYQKSNQSDCIVTCNYIDIISSRRIKELKVLGCLILEIFMAKQLRPVGSTGSNVNLENRLAYCLSIFSRCDIPPCISYIVNLLLQPEKEEYSAVTDMGLPPPSASLLLEPLMHCTVPFSKHFPYLYELLRNLKEFKSVAIELNILYHFDCDGHMCSEYENIEKTKILFAQNIAECKVKMCAKQLDILLDEIDTNTDNEVVNIILPHIKELIEDPPTSVLAAWYLFEPISRVLGPQKTSKYLLEPILKLYENECVDTHLPYIKKIAKLYHHSFLLCLMVRLGLKTFLENFVVPLVEAVGGYKDYDLVEFVLHNHIEKIVKRGSHLKTIESEQMDISGGDDSGSNDNHSKGLSGSFIVNEEIFEIEEEKNDEDQMKFLMEHLQLNVSSELPFNHSFAEEAVETTEDNVNLILHLEDELNDSPEALKSPTIPIPQSQHNHVNNITCEVGSKKSENEFTEQSVTPNSQKFESQKTKSSTKISDMSADSLVWLSHRLGPLLTAKYLSRNLLKMLALCYIGKDNISPFVPENVCSFKDISITSHYVKGDQPTVKVLECLTNISGLYGEQIIIFQYIPYMTELVLLCKKRITVNLEGGLISCVTLLKNIIPYITDSMLMNQLQDVILKSIINPIIRLLNSTNHVFPSGSTARNTLARKYLDVIYILAIRIGVDMTKKYLLVPSLQRFFLIFDKVFTNSSEEGKVSYTLADQESVVEDTNIEDDTKNKLQTNMSESHENIQLPEESVENKALIELQEVFTRELAHTAYLPFVRLLGLSCLQMALNNYDKICKLCQEYEEETKDSNTKPVSALKLSDFSPSTPVASSSSIGTNIAVIGNRIEIQSENVDCINMDLLSLVSNRIEYSNRHLRGNWLAYWEHEIGRSEKDIQLNFKQIKLQTFVGHTQSVKCLHVLDNENSFMSGSRDKTVKLWSLRSQGDGFSTSNCQWTYSAHKKSILSITFLESLRLVASCDSIVHIWDPFMGANVGSLESPKFAPVNTLKSMPAPSTLVFAATTDGTIKILDTRVLNYMQELKISNNPTSLIRCLAVAPSGNWVAAGQSSGNITILDTRTGFIIANWRAHESEVLQLQVYDKDTLVSSSLDQTTSVWNVLDGRLKFHMRGTTEPVHCLSIHNNELISGTTGNRIGVHTSITFEASFSNNKLRGDSFRGLLTSMDYLPLNRLLLLGADTGNINLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYX0</accession>
    <name>A0ABM5JYX0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase FANCL</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503136.1">
        <property type="nucleotide sequence ID" value="XM_050647179.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503137.1">
        <property type="nucleotide sequence ID" value="XM_050647180.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503138.1">
        <property type="nucleotide sequence ID" value="XM_050647181.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503139.1">
        <property type="nucleotide sequence ID" value="XM_050647182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503141.1">
        <property type="nucleotide sequence ID" value="XM_050647184.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503142.1">
        <property type="nucleotide sequence ID" value="XM_050647185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503143.1">
        <property type="nucleotide sequence ID" value="XM_050647186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503144.1">
        <property type="nucleotide sequence ID" value="XM_050647187.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647179.1">
        <property type="protein sequence ID" value="XP_050503136.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647180.1">
        <property type="protein sequence ID" value="XP_050503137.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647181.1">
        <property type="protein sequence ID" value="XP_050503138.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647182.1">
        <property type="protein sequence ID" value="XP_050503139.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647184.1">
        <property type="protein sequence ID" value="XP_050503141.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647185.1">
        <property type="protein sequence ID" value="XP_050503142.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647186.1">
        <property type="protein sequence ID" value="XP_050503143.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647187.1">
        <property type="protein sequence ID" value="XP_050503144.1"/>
        <property type="gene ID" value="LOC114329613"/>
    </dbReference>
    <dbReference type="GeneID" id="114329613"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23832">
        <property type="entry name" value="DRWD-C_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23831">
        <property type="entry name" value="DRWD-N_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.20">
        <property type="entry name" value="RWD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026848">
        <property type="entry name" value="Fancl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026850">
        <property type="entry name" value="FANCL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043898">
        <property type="entry name" value="FANCL_d2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044037">
        <property type="entry name" value="FANCL_d3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043003">
        <property type="entry name" value="FANCL_d3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11793">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18890">
        <property type="entry name" value="FANCL_d2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18891">
        <property type="entry name" value="FANCL_d3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCL UBC-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="3">
        <location>
            <begin position="197"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL C-terminal" evidence="1">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="44478" checksum="3A1916606E545D5F" modified="2025-10-08" version="1">MDPKDETDIKLLLNYPFISKRVEDDLIIYKGIIEVNDEDYQLTIKETSQKGFILEAGENLDFLDAEFSNSIRTTATDIVMVLDMLRSHISLKIPTDKLTNHSDTYRQVLCEYLEFTKFYLNLKSSYLAYDLSKISITMFDESNREHSVVIRVNYNDRNIFEIVDCDLPCEMEKFQKSSNLKAVYNQFVEDVERLQLFFNLMEDFDKNCNILDPVPPKKRYNFRRIWLGETLSVIITVDPFSLGRMPTIIFLGPERMVETYRMTMNNNLENWDTNNCIFSEILKLIGLDKFPTKPINEGKQDDILLEAGDCSICFSYRLNDKLPEIVCRNQFCDNCYHIDCLYEWLMSVNSRRFFSEVVGNCPNCEKNISCPIPNHRVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZG5</accession>
    <name>A0ABM5JZG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503329.1">
        <property type="nucleotide sequence ID" value="XM_050647372.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647372.1">
        <property type="protein sequence ID" value="XP_050503329.1"/>
        <property type="gene ID" value="LOC126882421"/>
    </dbReference>
    <dbReference type="GeneID" id="126882421"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="419" mass="48500" checksum="82D219D64942CFE1" modified="2025-10-08" version="1">MFCSQNRCRKIFLTFLTVTLFYSCPYVIMDPSIIIVDLKSSSSIFEQVDEQKDTTIDHETKDCIETSKKTTETPKQLQHEAEILYQCHLCNYSTRYSNLLGLHKGVTHPGKGRVNPQSCRQTSETGSQENISEENIVKGKNQKKKKIKDRKPFSDDEKILLLQLVSKLQLNKYDESVYTIKKTVTNKWTEVSKIFIEKCYDRRSEELGIYFLKMKYAAKSKFESYYVQKCAVRPTKEDYILANLFPKFYESLGFDMSQLMTDAKTYSKEIQEYLVPVEDQERPTILEDIASLNQLNDVEAQPKKRPHSEEAEGPANKITKEVHEDEGAWLKRMLDITRGRNNCEAATSKSLINENNSSTDAINALKAKLLVAENETREKDYQLKRKNLEISYLKELHAKEIEIEKVKLLLHAQNVANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZY0</accession>
    <name>A0ABM5JZY0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503496.1">
        <property type="nucleotide sequence ID" value="XM_050647539.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050503496.1"/>
        <property type="gene ID" value="LOC126882567"/>
    </dbReference>
    <dbReference type="GeneID" id="126882567"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30908" checksum="970E1EBEF20A7EA2" modified="2025-10-08" version="1">MNEKFKRQKREESKKYSEETENERVQRKLKEVLEILNGKGPIEGENKAKARKLIGKITSIQNKTSQNQNQTVQEEGHLKCEQCKIKMEQERQKKETEKIIKALNNGGDINNFSQIYKKKWEEKSDIKEGGVESVIRTIREDVYEIIEGCKEENVEYIENVKKSSMASERREWFTDVVKIKKHGIYEMAERAIKQIKERETPPQTIRVIINNEINKEEVRKALEFVGRGENIIWELVIRGKEMDRGARHEQEEALLIKTGGKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K163</accession>
    <name>A0ABM5K163_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503930.1">
        <property type="nucleotide sequence ID" value="XM_050647973.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050648043.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647973.1">
        <property type="protein sequence ID" value="XP_050503930.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="XP_050504000.1"/>
        <property type="gene ID" value="LOC126882878"/>
    </dbReference>
    <dbReference type="GeneID" id="126882878"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053071">
        <property type="entry name" value="GPCR1-related_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47023:SF1">
        <property type="entry name" value="SEX PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="421" mass="48317" checksum="5433548A18BE2EA9" modified="2025-10-08" version="1">MFSIKQVGHHPLNICALFQINIQMYANMADNTNNTTSVASTNNSWTNTSIIQMELNMSNINFLNITLEMPITYATPLYGYLMPILLVVTMVANTLIVIVLSKRHMRTPTNVVLMAMALCDMFTLLVPSPWLIYMYTLGNHYKPLFPASLCYSWNLMHEIIPCIFHTSSIWLTLGLAIQRYIYVCHAPLARKFCTLPNVYKSVAGVLIVAALHQVLRLFDTEYATIDIPWENTTTPICIRRRAEWVNEYINEDVYFVTYFMFRILFVHLLPCISLVILNLLLFRALREAQKRRDILLSSKKGQKNECKKLRDSNCTTLMLIVVVTVFLVVEIPLVVVTILHIISSTLCEFLDYEVANTLILFTNFFIILSYPINFAIYCGMSRQFRETFKELFIKNAANARNGSSKYSIVNGPRTCTNETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K170</accession>
    <name>A0ABM5K170_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protamine-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503934.1">
        <property type="nucleotide sequence ID" value="XM_050647977.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647977.1">
        <property type="protein sequence ID" value="XP_050503934.1"/>
        <property type="gene ID" value="LOC126882901"/>
    </dbReference>
    <dbReference type="GeneID" id="126882901"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024460">
        <property type="entry name" value="Protamine-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06382">
        <property type="entry name" value="Protamine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14849" checksum="E48D776C2F261C2D" modified="2025-10-08" version="1">MARGSNESIPSSNDNKEETRKGAKTPVKYKPGRITRNPFLNFLRIFRKNAEGMSVKDIAIKGGNLWRKMDQQQKKLYLDQAKLAPYRPRVRRRNRSASRGRGRSKSRSKSRSASRGSRRKRRRSSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2J5</accession>
    <name>A0ABM5K2J5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504410.1">
        <property type="nucleotide sequence ID" value="XM_050648453.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648453.1">
        <property type="protein sequence ID" value="XP_050504410.1"/>
        <property type="gene ID" value="LOC114339121"/>
    </dbReference>
    <dbReference type="GeneID" id="114339121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="766" mass="87766" checksum="CC5E303682940D49" modified="2025-10-08" version="1">MYRQVLVEPAQRNLQRVIIWRNDPSQEIIIYQLNTVTYGLASSSYLATRCLKEISIHSSATFPEESRKLNLDTYVDDVVTGASTKQGLISLRRDLTSILSSYGFNLRQFSSNSTALLSDINVDDHKEEYIITDSPNSKTLGISWNSLTDSCIYNTRITANPSIITKRTILSTIASIFDPLGCLGPMIVQAKVLMQKLWIQRLNWDDPIPVELYKIWKSFIDNFTLVNSFNIPRQVTTKDPIYIELHGFSDSSINAYGACIYVRSIDIHGRILSNLLCAKSRVAPLKAISLPRLELCGALTLARLTKNVIESLKLTFSKIYFYTDSTIVLCWLGLEPRTLKTFVCNRVSEIQQLTKIDEWHHIPSNLNPADIISREASPSELHECDLWWHGPSFLLQSQDTWPSNNHISNFTAHTPDPDLMELNPKSIVLSSQVSPSILISSLVNRYSSYTKLRNVLAYCFRFIHNAKTSREFRIIGDLTLTEMVQSTNYLVRHVQRESFPEDIHQLKSHGKVKLSSKLNSLNVFLDDLNIMRVVGRLRHASIQFSAKHPVLLPHKHPLLKTNAIRDFSQENKITWHFIPARSPHFGGLWESAIKSIKTHLYRIINNANPLFYEELYTLLVQIEGVLNSRPLLPMSNDPNDIEVLTPGHFLIGHPLNMVPAIDYEDFPINRLTRFELLQRMMQHFWSRWKNEYYTLQQREKWRYTKDTAKLQGQMVLLKDDGLPPYQWSRGRISALHPGKDGLVSVSTPNGTIKRSITKLCPLPVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3Q8</accession>
    <name>A0ABM5K3Q8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504815.1">
        <property type="nucleotide sequence ID" value="XM_050648858.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648858.1">
        <property type="protein sequence ID" value="XP_050504815.1"/>
        <property type="gene ID" value="LOC126883373"/>
    </dbReference>
    <dbReference type="GeneID" id="126883373"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="145" mass="16132" checksum="63FD23D615D85F7A" modified="2025-10-08" version="1">MLLEPIANTITSVEGDTPTISKCLHLLKKMVNTSLENVTKSPLLSKEEADTRAIFENRKKFAIYSVHFVANLLDPKYRGCELSSDEMTDATEVIYKVAQKMPDVDEAAVLADVVNFIAKEGLFKKAFLWNEDTIAAILASQSILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4W9</accession>
    <name>A0ABM5K4W9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505229.1">
        <property type="nucleotide sequence ID" value="XM_050649272.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649272.1">
        <property type="protein sequence ID" value="XP_050505229.1"/>
        <property type="gene ID" value="LOC126883619"/>
    </dbReference>
    <dbReference type="GeneID" id="126883619"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67582" checksum="BE36526EB8D10C9F" modified="2025-10-08" version="1">MALELETKRRTVLRTAFTTAANVLDNLLSETVDTRPWQQISVQWELLQVKYNELCVVESAVFEAMVEKASEAELISEMEAKDRYSTRYYELKYKCEDRPSLVSSESSIKGKRSFKLPPIEFKKYSGDLIDWLPFWSQFKVVHDDPSIDLNDKIAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEEYAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKCKSNNLVEKKNIKLPKQGTDQPSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKNCRARLNCILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA01</accession>
    <name>A0ABM5KA01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507016.1">
        <property type="nucleotide sequence ID" value="XM_050651059.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651059.1">
        <property type="protein sequence ID" value="XP_050507016.1"/>
        <property type="gene ID" value="LOC126884813"/>
    </dbReference>
    <dbReference type="GeneID" id="126884813"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="510" mass="57386" checksum="09D8AD6313167857" modified="2025-10-08" version="1">MSIEIESADVIRLIQQYLKESNLFRTLHTLQEETGVTLNTVDSVDGFCADINNGHWDTVLKAIQSLKLPDKKLIDLYEQIVLELIELRELGAARSLLRQTDPMIMLKQNEPERYIHLENLLARSYFDTREAYSDGSSKEKRRAAIAHALSGEVSVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAVREQEDETFPTQMAKQIKFGQKSHVECARFSPDGQYLVTGSVDGIIEVWNFTTGKIRKDLKYQAQDNFMMMEHAVLCMAFSRDSEMLVTGSQTGRIKVWRISSGQCLRKIEKAHSKGITCLQFSRDNTQVLSASFDHSIRIHGLKSGKTLKEFRGHTSFVNEVIFTQDGHNILSASSDGTVKVWSIKTTECTNTFKSLGANDTAVNNIHNFAKNPEHFVVCNRTNTVVIINLQGQIVRSFASGKREGGDFVCSTVSPRGDWIYCVGEDMVLYCFSTNSGKLERTLNIHEKDVIGISHHPHQNMLCSYSEDGLVRLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBA8</accession>
    <name>A0ABM5KBA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507474.1">
        <property type="nucleotide sequence ID" value="XM_050651517.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651517.1">
        <property type="protein sequence ID" value="XP_050507474.1"/>
        <property type="gene ID" value="LOC126885093"/>
    </dbReference>
    <dbReference type="GeneID" id="126885093"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037863">
        <property type="entry name" value="RHOGAP6/36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635:SF7">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="805"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1501" mass="167610" checksum="AF7898816B78D2C3" modified="2025-10-08" version="1">MSEKRNSKLKALGRSASTESTEYSITMGKSVRKKSKKAKPKERWLLTRKTWRYMADAGRKLIPDGAQNRVEDIPKIEAYFQEVCKKEPRFLLWRKNSYPGAIGFRQKKKRVSRKGGSCRNAVSADEVSLGKPDKPTRPTHLAIEHTSTGKFDVRRLKEEFLSRNGNPSGYSSYDQKMSPTGAPEETAEDKQLINMLEQYLSLGKEETVPEKAKADFNYQDLVDKLQRHLTLYGGDYYSAGHSSHLPSQHTQHAQHAQHAQHTQHVHFEGDHMQRSLLDTLSRYYGQSTNRDKIISDLLTDRRALEKLYFELRKTKGFRGSRGGTGYTTSFAYGPQRSNYENTSLKRLLKEKESPSTPTHPPPLIEVETATAEPSFHNWGTQTLPIPEAVLQKVEEDYRKLQEERGDEVPTKDGKSFRRRSSVDNDDISQSVSDTIKRYLRMARKKSVDVDKVDRFKRVNYDRNLRNIKAKGEITKPGDDDGLNKGCQTNEEWILTYRDLKFSDLYDVSDVESRFSSSRSSIDIGVVDEGAKSLPSSPPSAKSGHSFLSQLLHGKHDKHDKSDKSSSAVTSGATMQKSKSSSSVMHHGSRLMAKKIFKSRSKSQTRSTHPCSWTPQGSCVWSNITGRQVILGDTSLLNLTDIERKVLQKVAIAKLQALNLGVNIKVPTEAAAGVSSKPKRRPYLLKRKALTTGIFDASRKEAEKDKENSGSQGGLVFGISLAQCVENDRLTRAAAGTSPFRSRGELSGSGDEPSKIGRHGSRSSFSSLIDSPRNDEKGSCENLVLHKRMIGSVPGLLDSISCSSNADIPAAVMEEEAAVPNILTECFRHLERHGLHTLGLFRVSTSKKRIRQLREDFDCGKESSLEDEQCPHDVATLLKEYLRDLPDPLLCRDLYHAFVQTQRIRNRRLQLEALQHLVQLLPSANRDTLYALLSFLAVVAKYADDSQNDSGEAVSGNKMDTSNLATVFAPNILHCIKPGAKDISDRPEDRIDIINVVRTLIDHYKSIFTISAELLDEVYLHMMDTNAEELEVLLNKKDGSAAADESVDELDSESNSAPWTPVTLAHDPPLDSIFDSKLAEQKKTYSREEFLHEAAATGGPNVGMRIRHKDRIREKSYRRRREKTEDGKEGSLTSSALTIISRLRGQKDDDGFKNRSSSIESTSSTHTDDMARMMKSSDNLYERRKSSPYVLDNSGVITASLTIPVHTQNQSLSYNVDDDIPFIEDGENGRQQMTIGLIRTPSVPPRRRNHSLDSDSSVTSSVQPITGSISVVPGYDSAIGSTTTYSSPIQNTPTSVSSSIADAGVYSSAASWTSSPPTSPDSTRTSVNYIPDDPQASKSVIKILKSNIVRETAPTLQKVSFSSTQEIQQVKDGKDPSKIYQREVSFNKQKYSTPSADVQREPKFTPSINSIGNAVLRSKTADFERIMKETKTKTAQSTTVDREKKKYTKRRYTDSRHQTRHIPDAETLESTSAQSKRDDKAGNSQSGPVYKRRELISSVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBU2</accession>
    <name>A0ABM5KBU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507655.1">
        <property type="nucleotide sequence ID" value="XM_050651698.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651698.1">
        <property type="protein sequence ID" value="XP_050507655.1"/>
        <property type="gene ID" value="LOC126885233"/>
    </dbReference>
    <dbReference type="GeneID" id="126885233"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045350327" description="Saposin B-type domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="107" mass="11733" checksum="22B9866C1DB2B0BF" modified="2025-10-08" version="1">MKAVIFVTLFALIGLVQPTYIPEDDKSLEIPIACEACVAFAKIIEGLVEKEVPKETVEKEAEKLCELLSGSLKQFCEDHLVSVVDVIYDAISKSSPLLVCTALQFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCB0</accession>
    <name>A0ABM5KCB0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Xanthine dehydrogenase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507820.1">
        <property type="nucleotide sequence ID" value="XM_050651863.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651863.1">
        <property type="protein sequence ID" value="XP_050507820.1"/>
        <property type="gene ID" value="LOC114324830"/>
    </dbReference>
    <dbReference type="GeneID" id="114324830"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="15">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="199"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139507" checksum="A5E80E432D174C43" modified="2025-10-08" version="1">MNRKKSVQLSVGGVEYTVSPEDVGPETTLNEYLREKLHLTGTKRMCLEGGCGTCTVAVEETVNGKKKIFSVNSCLVSIMSCHGWTIHTIEGIGNPLNGYHTVQKTLADNYGTQCGFCSPGMVMNMFALQSSGQNTKAQIENSFGGNICRCTGYRPILNAFKTLAVDKEQLPDIEELKLCKNDPNKICTNDCKPKDNFYLELKDSRWIKVHTLRDLLEVIKISPTNNYMLVCGNTARGVYRDTRPANQYIDVREVAELTRYYVNPTALKLGANIVLTDFMSICTKVSANPGFEYLKTIVQHVDLVATVQIRNVGSLAGNLMIKYRHNEFPSDIFLLLETFNASIRLVDVDGNESFCTPQEFLRVDMTRRVIKNIILSTLDSSYKYATYKMMPRAQNAHAMVNAGFLVKLKNNVVTYANIVYGGINPQFIHASKTEKFLIQQNLYKNDTLQKAFNSLKQELIPDWVLPDPTPEFRKNLAISLFYKFVLKTSPPNLVGARYKSGGTILTRALSTGVQQYGTDNKQWPLTQPIPKVESLAQTSGQIKYILDMPDIPHECHASFVTAKCVAGSKITNVDVSQALKIEGYVGYVDKKDIPGRNTCTPLDSSMGWSVEEELFCSGIVQYYNQPVGLVIAKTAQAAHMAASLVQVKYTPPQNKYYLDVREVVADNVASRIHHVNTVLPRNKGKDIKHTIKGDFFLDKQYHFHMEVQCCKVVPIDDGGLNIYASTQWMDAVQIAAATVLNMPSNKINVKVTRLGGAFGAKILRNNLISAAAAVAAHKLQIPIKLVLTFEQNMDIIGMRFPSYMKYKVGVNDTGVIQYLEADVYCDVGVGGNEPFNQLFTTSFENCYNMDSWEFSTYDVKTDTPANCYTRAPGTVEATAEIENIMEHIAFTLNISPDAVKQANNSTTSSPKMPSYWTDLKSWANIDQRKADIEKFNAANRWNKRGLSIVPMRWVLDVNLSFSVLVSIFHRDGGVAISHGGIEIGQGINTKVIQVAAYKFGIDMDKISIKPSYNFITPNNGCTGGSLTSEAICYAVIVACDKLLAKMKPVKDKMNNPSWVDLIQACHAASVQLCDTGFYHGNAPNVQPYPIFGICATEVEVDILTGQHQILQVDIIEDLGQSMSPLIDIGQIEGAFVMGIGYYTTEELIYDKNGKLYTNRTWNYKPPGAKDIPINFRVKFAENSINPVGVLKSKAVAEPPICLSVALAFAIRNALYSARKEADPTHIEFLTMNGPTTVERTFLYSKNNYQQYVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCI7</accession>
    <name>A0ABM5KCI7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507901.1">
        <property type="nucleotide sequence ID" value="XM_050651944.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651944.1">
        <property type="protein sequence ID" value="XP_050507901.1"/>
        <property type="gene ID" value="LOC126885382"/>
    </dbReference>
    <dbReference type="GeneID" id="126885382"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="82"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="420" mass="48522" checksum="F6A92693182862AB" modified="2025-10-08" version="1">MYGKRARSNNITMPPIFDIYRKPIFDESIRKAEYRTYASFIKSFNCNDIVEFSINQVDSFFAMSETLLCIKGSLEITGNGGVKLANNVGAFLFDSCTYSESAREMETVRDPGIVSAVRAMTCYTQEDSNYMVMAGWNYPKDPILNAADHSFSIQMPLKHVFNIFNDYPLITCGRQTIRLVRARNDNDCIVITEKQNADKTTTVTTAKINITNIELRVKHIFPNDDIKLELMKSIQQDQPIVIPFRKWELHELPAITRGARREVWAVKTSTSVERPRYVIVFFQTNKRDKITADPTLFDNVNIQSIRLSLNGEYWPNERMQLDFSKTDYNEAYFNYTEFYPSYIHSQQKRPLLDFSAFKNRALFVIDCSKQEESMKASTVDVKLDIEANNGFPDNTKAYCIIIHDCVMEYFPLTEIVKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCL3</accession>
    <name>A0ABM5KCL3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507933.1">
        <property type="nucleotide sequence ID" value="XM_050651976.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651976.1">
        <property type="protein sequence ID" value="XP_050507933.1"/>
        <property type="gene ID" value="LOC126885409"/>
    </dbReference>
    <dbReference type="GeneID" id="126885409"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="555"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="672" mass="77609" checksum="481124E40C980EA8" modified="2025-10-08" version="1">MMDRRKFYKKVISEFSQVRAKRKLSFEDEIASNPTQEQQSSELTSLLDNNQPLTSIENMGDHVSSSRIFYKNHQSISKSEIHKNTDVPQIECLQNNNTDGHNTETPPTLEGIVDTVAEFQRTIDSNVIDSNVITNTMENLVAKDAASDPINIKQNTKRSKRPRLNKNTYCEFISDNEDPFFTDGSSSWSDTGNTSSDTSTHNKRPKKKIVKKTQKVSKELASKTDDIDIVGEKGKRTKRINYRKNRKDLKNRGQEYTRADGIIRSKREIKPNPCIGKKCGNGCQNVTEERRLSLFHHFWSLSSARQRDWIVNMSRRNSIKRKRSKDSGKRSFSYEYYINDNEDRRRVCQQFLLNTLDITQTYVHYTLTNSIEGSAKDDLRGKIIPANKTKETTRQSVINFIKKLPALPSHYCRKDTTKLYLPVEFRNQKNLYRIYKGEKTSEGIDYVSEKIFLNIFNTEFNIGFHIPKKDKCLKCIKFDAANTEESKAEKEDHLMEKKASKERYSFHREMSQKRTDLICTSFDLQKVLNTPHGESMLLYYSRKYAVYNLYFYENGSREGFCYIWGETEGKRGSNEIASIIQKYIDLVDARISVKHLILNSDSCPGQNKNRIILSAIHNALKNCENIVSIQMNYLLPGHTEMSVDSMHSVIEGAVKKYYCMGPFAMGYSLSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE95</accession>
    <name>A0ABM5KE95_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508519.1">
        <property type="nucleotide sequence ID" value="XM_050652562.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508521.1">
        <property type="nucleotide sequence ID" value="XM_050652564.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508522.1">
        <property type="nucleotide sequence ID" value="XM_050652565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508523.1">
        <property type="nucleotide sequence ID" value="XM_050652566.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652562.1">
        <property type="protein sequence ID" value="XP_050508519.1"/>
        <property type="gene ID" value="LOC114339984"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652564.1">
        <property type="protein sequence ID" value="XP_050508521.1"/>
        <property type="gene ID" value="LOC114339984"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652565.1">
        <property type="protein sequence ID" value="XP_050508522.1"/>
        <property type="gene ID" value="LOC114339984"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652566.1">
        <property type="protein sequence ID" value="XP_050508523.1"/>
        <property type="gene ID" value="LOC114339984"/>
    </dbReference>
    <dbReference type="GeneID" id="114339984"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028480" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="261"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="745" mass="83339" checksum="F2BA50F023958DBB" modified="2025-10-08" version="1">MDLKIMYLFLSYLASTMAQEDWEKHCNKCHCLWVSGKKSANCAARNFDTIPNDLSGDIREVDFSNNFFYSLDQRVFENAHLVNIHKLKLQNCTIEKIHQWAFTGLGLVIELDLSTNNIVTLNKYVFRPTVRLRTLILSQNRIQILEDELFSNLTYLQKVLLDHNEIETVSQETFRNLPNLKFVSLSFNKIERITFDIKEQLPKLSSLNVENNRWICDCELDIFRRSVKHNKLITDKVICSGPKRLENQSWLEDSVVFACSPKIMDVGPYSTVQAATNNVTLTCKVIGDPTPDVDWINNGLIIERDPRKDKQKYFTFKETIGGYTWNNLTIVNLNYKDKGEYKCIAKNPGGYTERNITLDILPGALTGGGIVGTLSTSTTLVIGLTVGLIILLFLVLIALFCFCRRSTHGFYSKRRPNATTSEEYINMSTGQAEIKKGLITDVNPVTKPPRTSVSPSVVSGGTEVSDVKKTLLDNESVFDGDEDSRSFDFDQPHRKGQIMLDTGPNHYPPDLLPFPPRLAQVSPAGSSASTVADTTRLPPTHGPQSPLHSPIYDQLNLYRTLPYSRSHSPFVGPPARIPRTGYVTIPRRPRMQSWSSEPPNVEELIAEPLYDNLGARTTADGGTSTLSLNKLDSTASTPRSIRLLPLSPTNCDPIAESLESPPSQPLASQTLPRNLHATKLTPSKLQWTKDNADALRSPEKRNSMSSLPADGQPIKKIPPRPPPKPKKRISTGPLFEDEGEDGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEL4</accession>
    <name>A0ABM5KEL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508641.1">
        <property type="nucleotide sequence ID" value="XM_050652684.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652684.1">
        <property type="protein sequence ID" value="XP_050508641.1"/>
        <property type="gene ID" value="LOC114337084"/>
    </dbReference>
    <dbReference type="GeneID" id="114337084"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF41">
        <property type="entry name" value="MUSCLE-SPECIFIC HOMEOBOX PROTEIN TINMAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="313"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="473" mass="51817" checksum="2888FC50F6B13A1A" modified="2025-10-08" version="1">MRARSKRVLKESKKESWKKFVNSITSDTPPAQMWTKIKQMRGLNTYRKIPAITDGDNIITNDNQITETLAKYFQNKTKSELSVPYPTNHSPPIPIQTNPINLAFTEEELNLAISSMKNSSAGGSYGEGPVVPGDRGDLHGLLPELNGVELAMSLSPKHLQGPQVLSHLQQLHHSTPFSVTDILSPIEESYRKLELSTNPPSPYRSTSSGSSINSPGISGSGGNGCSMNGSYPVMGQFGGGQYCPVSENLGLTPHYSSGWYQTSAADPRFAISRLMGSTATAANMGHGLNSGMPGLGACAVSDSKPMQFPLAQRRKRRVLFTQAQVYELERRFKQQKYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQHNQSSSSPRRVAVPVLVKDGKPCSGGGNNTNQTATSSASSDTSRTQQSPACQPPQQQTQCMANSGLAMAYRQQGNYQQQCAGYLPLQTRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEW5</accession>
    <name>A0ABM5KEW5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508730.1">
        <property type="nucleotide sequence ID" value="XM_050652773.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652773.1">
        <property type="protein sequence ID" value="XP_050508730.1"/>
        <property type="gene ID" value="LOC126885951"/>
    </dbReference>
    <dbReference type="GeneID" id="126885951"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046571729" evidence="2">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="232" mass="25216" checksum="B4B30C8528D8DE0B" modified="2025-10-08" version="1">MKVCLVVSLVACLSCISLAVEVKHKSSHSAAQGHGHDNKGGQVVVKKHGSSSGKSSKHDEAHANKGQKLENLHKTSHLEKGGKKTSHNEEGGHQSAKHSSGGSHHGLKYQEGKKHKKANYLKGFREKYHKDESNKHDSFFSNGEKSGEFEIFGKKNSKYSSESFAKKKGKNHKNASSAKAGGKSYKSGKTHHDSDAKAHKGQGGFEKHHKSAEKFAKKHASHGGKKYKVHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFE4</accession>
    <name>A0ABM5KFE4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508921.1">
        <property type="nucleotide sequence ID" value="XM_050652964.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652964.1">
        <property type="protein sequence ID" value="XP_050508921.1"/>
        <property type="gene ID" value="LOC126886119"/>
    </dbReference>
    <dbReference type="GeneID" id="126886119"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="534"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="761" mass="87101" checksum="5C85AA5CC57308C0" modified="2025-10-08" version="1">MYSQQGSRGSKLLALAAGAIKMGQAMGQKIGSNDLKSSTTVLEYIVPEEHENFANEIKSSTIVPQCNQVDIEQKNSTTEIKLGNIVPEEQENYSKEIEPSNPVPECHEIHIEQTAEVELVATVPEDQATHSRWEYENVDDSDLDPDFRMPHSGSDVSSASPTTSQEEETEIDNTQVDDRRKCKKRKANPVEWKKSKSKLLRNAGKSYESSSFRKTKFPAKNLRPACREQCKLQCSNKIDEPKRLEIFNKYWSLGNLQSQREFISRSITPIKPQYQYRKEGSRRQCNHAFHFLISNVKVRVCKLFFKATLDISDRPIRTVIAKLNEGFLQEDLRGKHGHHPQVDSAIKDGVIDHINSIPRTESHYLRAQSTREYIEGGKSLADLHRDYKNECIQKNVPYANITMYSRIFNNNFNISFFTPKKDMCDLCNSYNNATEDEKVVLNQKYDTHLREKVLSREEKEEDKKRAVLSEGNIIVATYDLQAVLPAPRGNSSTFYYKSQINSYNLTVTELQSDNVQCFFWHEGEGARGAIEIGSCILKYLEEKANATNNNNLEIILYSDNCCGQQKNKFIMGMYLYAVQKYNIKSITHKLLIAGHTQNEGDNVHSVIEKQIKRALKSGPIYIPTDYVRLIQSARKKGNPYKVTELGYQDFMDLKTLSQQRGSNYNKLSDNELIRTSDIIILKVQKNNPGIIFVKTTYEQKEFAQINVNHNRRSMQISTSECVAAYKKKMQISALKKAHIESLISAKSIPTLYKPIYESMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFG9</accession>
    <name>A0ABM5KFG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508939.1">
        <property type="nucleotide sequence ID" value="XM_050652982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652982.1">
        <property type="protein sequence ID" value="XP_050508939.1"/>
        <property type="gene ID" value="LOC126886135"/>
    </dbReference>
    <dbReference type="GeneID" id="126886135"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="408" mass="44349" checksum="E66EC02DEEF43604" modified="2025-10-08" version="1">MSNIQKTIIDSIEKGNPSFEEIGYYSQAINNAFYAVFTWTVPSIINGFGAKWSMCLGALINLLFIIQFLLEKVWIVYVFCGLSGFGSALLGAAQGNYLTLNSSESTMNKHTAIFAIISSFNMIVGNTIVMWGFSSGGEISKSTRTLVLTMLAGVGTVGLIVLVFLPNHKKDEKDKDINKTSALETFLDAVKLFTTKNMLLLSVIFLYEGIATGFINGIYSSALGFTQNLHNPKQLVGLSGIFVGIGEIFAGSMITIFDKKVVALGRNVMAVTACSVHSISFILIFINLPNNSPFANTTDAAIIESNTVLAMFCSFLLGLGDCVFVNLIFSTLGTMYPENSASAFSIFQFFVGISSVINFVAAEHVGIYYQLITLFILGIVSILCNLKVDTTGKQNELMENEIKKEVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG05</accession>
    <name>A0ABM5KG05_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein on Y chromosome-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509129.1">
        <property type="nucleotide sequence ID" value="XM_050653172.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653172.1">
        <property type="protein sequence ID" value="XP_050509129.1"/>
        <property type="gene ID" value="LOC114341818"/>
    </dbReference>
    <dbReference type="GeneID" id="114341818"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051242">
        <property type="entry name" value="WD-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 49-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44324">
        <property type="entry name" value="WD40 REPEAT DOMAIN 95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="79711" checksum="BB59A2E0378E7A47" modified="2025-10-08" version="1">METNGISDELHSLSLDSLDETNQNTAWYGLIKKFNYDQLDSLRTRFKEKIKDGKEIGLTKEQFSECIGQMFDETKYLLQCNVLFEDIAKSHTRINWDDFLDFLLENIPLRTEIPVNLHLTSVESMPHMNREIITKIVLLETEKYFSYAVISKHGIIGIYDGNLNFLTSYHVIMTREDLERTDDERRRKNRWVTDAIFCEDIQMLFVANSTRSIAIYEASGLKHEPYWLIMGVHHIIECLSYKNLYHTQSDNKLKCALFAGTSNGDVVMFKFIQPTTLLLRRKHMDRITLFYWDELKYEKIYLKIQSYKAVHNSNVEQMEYCSVENAVITCSKDPNVSLMKKYMSPNKQPYILKMRKGCNCFSFSTTLNILVTGSDDKTIRVWNSVLASNTIAVFTGHLQRIIDVSIMDNQKTILSFSEDGILKLWEINENKCLQTINIEFPAFNILGKRIEFGRRNIYPGAKRSSKHLRYKDDISLHKKYFGISEVEERPQLDEEIRGTHTNKWERSNILLTCCNHIASIRTNFEDNNIERLNETSILPSPPLQNSVLIPNCWQIPITELNEDNQCNEEESTESNEELTFITENNSFDLWTVKTDINYKIAVLEAKKMQMKAHVASGAPYLALDLSEFEELKLSDNLVIPEKKEIRSTIDKIKKRLEDVSMREKAFSEPSSSRSKKSSRSSVISIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGH3</accession>
    <name>A0ABM5KGH3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED16</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509306.1">
        <property type="nucleotide sequence ID" value="XM_050653349.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653349.1">
        <property type="protein sequence ID" value="XP_050509306.1"/>
        <property type="gene ID" value="LOC114328374"/>
    </dbReference>
    <dbReference type="GeneID" id="114328374"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048616">
        <property type="entry name" value="MED16_bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20718">
        <property type="entry name" value="Med16_bridge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 16 central helical bridge" evidence="13">
        <location>
            <begin position="462"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="14">
        <location>
            <begin position="729"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="814" mass="91353" checksum="58DCD3A84A0BD34D" modified="2025-10-08" version="1">MDHIFTISKKPSRSLNPYKQNIFNKLEKSILCSVSSTNVIAFSTESNIEECNSLYWSSNVYVADLNSPWQIHKVLSNSSPVTVLQWDFTGELLLIADESGCVRIYSAKDHILNDWNIVLQTVLQGEHILAAAFFHSGKRICLNIEKKDSSSYIEKFQHVKFACSVKQFGSKPAIGALLLTTTGMLAAVLLPQPTCQTPMTMATESLGPTRMFIKTADICYGKNGHFLLAVSSGDPSMPIQCYKVSVKKEEEKCTIVSQSLLSFFLNEAPKEALMDQISKEKNCTVSHIKWIMREDADSLVVAASSPKMSCLQVWELREKALPVHKSLGKAEAPQFFNTVLWQYQCHFQYNSLVTSLATSKLSLINSVSSGYVVVTFADNSIHCLYRDTLKPIVYTTLSVVPRYLDEPNAKYQKVSTNISNIDLSWLGNVLLCVDSDDSLHLFKLPPQIDSSTPLSVPYCTTILEYCLVSGLDWLDLLLVLRPGMLDAICDRLTESFNRQPPQVQQFFHVQYLCIKISLYRLSFQGQGKANDLTQYLMLHSISTAFKSLLRPSEMNSHEKSPADSLASVIAEGQNDVDKALTSMHFEAKEFTVETTTLQSLQQLIQWVADLALNLLLKLPDSRPATGKSYELLRDVKALNMLREMLVLIRIWGLLRPACLPVFIKSDTNLDVLALVFRLLSRLVQNVNEPDESLIDECCQLPSQVVQIPLLQPCNNRIVLGSPQLAQQILPLQLEFNNEPECLTFNVDSNSNQTIDSVRHLYLGKFPRKVKQCVRCGGSAGTVPVTRTAAIRAWDQRWLRTCQCGGQWRMQVFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIR5</accession>
    <name>A0ABM5KIR5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase beta</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Rough endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050510094.1">
        <property type="nucleotide sequence ID" value="XM_050654137.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654137.1">
        <property type="protein sequence ID" value="XP_050510094.1"/>
        <property type="gene ID" value="LOC114335571"/>
    </dbReference>
    <dbReference type="GeneID" id="114335571"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="639"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="921" mass="103539" checksum="A599B3A33DA9F799" modified="2025-10-08" version="1">MNGVSPAGGLVQPQPQPNVTTHLKRQKLTSCRDSVPSVHGRPNSSLNIKTRLSNHQRNLSLDFRSMGILLPPVTQVTTSTTNHLTHHHRNRSLDSALQRIPEVDVTPSPECETVNAILCSTVSNTSEPHPKSSSKQRNDELASLGSDDSGILCGSDAGSSSESNATRESSVEYIDNIAAERKTESKEEVDCEEDNDDDSERTKTSSSSCSSSDAPKSSGMLRLLESKVFDVSMAMHYLFNSKEPGVLCYIVNKMFSFDNHEVDFYLPQLVCMYIQMHDVAEVIHRYLIHRCRKSIDFSLKCAWLLDAFSSDASVPTKKKPHGIKLRNLILSDELRPKDHKIMTTSLNSASGDKLTVPQHIKKTHQRSHSDASALFPGLKKSAPNATKLSLGDLSSGRAFDNGCVCFDSCQSVVNDLRGEKTECICSAPRLRPELEFMQALILIGKLLSSIPTKEAKTTRLVAELTTLNLNLPARVWLPLNSQYPHFIVRIPPQVAAVLNSKDKAPYIIYVEVVEVEDLESSPVPPKIMPTLRHTKSEENLKHESVSLSAFSMCGGCYDDLDPDWSQEDDEISQQYNQMRKPVDRDTISQMSQESSDSREPPMSIPASEIRRRLSDFFHEEKNKQFTHDPEDPSAAVLKEPWQDKEQRIRESSPYGYLSSWKLLSVIVKCGDDLRQELMASQILETFQKIWELEHVPLWLHPYRILCLSDDSGLIEPILNTVSLHQVKKHCQLSLLQYFINEYGPMTSEGFLTAQKNFVQSCAAYCLICYLIQVKDRHNGNILLKSDGHLIHIDFGFILSTSPKNLGFEKSPFKLTPEFVEIMGGENSDMFEYFKILILQGLIAARKHHAMIVTLVEIMRSGSQLPCFKSGASTVQNLKNRFHMSMTEEQLRLEVNRMVEGSIHSLSTKLYDGFQYFTNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJF1</accession>
    <name>A0ABM5KJF1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510336.1">
        <property type="nucleotide sequence ID" value="XM_050654379.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654379.1">
        <property type="protein sequence ID" value="XP_050510336.1"/>
        <property type="gene ID" value="LOC114328177"/>
    </dbReference>
    <dbReference type="GeneID" id="114328177"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF303">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="802"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="839" mass="94655" checksum="E1A051935F2CD6F1" modified="2025-10-08" version="1">MYENNIHHKHSKMEDVGLVMKEIKSNNMPIKRLLKHEVEVIPAVEETEENDCDIEPIEPLEPKQIKEIKEPVEHKLPSSAGSFNKAPKTHQDIPMYSFNSISSHQSSPNFRRNNSVRSLKNYHHLLGDLGQKPPSSESGIVSKSSDAASLRSWSSVYMGSTDGKKMIVRRVPTSPVELFNIVNPPTPPEAYTLENDTDDETGDEDNDEYGKPRRQQWSNKLQFVLACIGYSVGLGSIWRFPYLCYKSGGAVFLIPYAIIMIFIGGPMLYMELAIGQFTGRGPIGALGHLCPLFKGTGIASVVISFLMSTYYSVIIAYGIFYFFTSFRVNQPWDDCSHRWNTQHCWDQVKQRLNHSKPRYTQSPAEEFYDLKVLQIGKGIEDSHNLRWELVACLLCAWILIYFAIWKSIKSSAKVRYFTATFPFIIIIILLIKSLTLEGADVGMRYFFKPKFELLLNAEVWVNAASQTFNSMGCAFGSMICFASYNKYNNSILPNTVAVWLLNSVTSLIVGIFAFATIGNIATEQGTSIEDVIDDGPGLIFVVYPQAIAKMPASQLWAVFFFFMLICLALNSQFAIVEVVVTSIQDGFPGWISRNLTCHEVLVLVICVVSFLCGIPNVTKGGIYFFQLIDHYAASISIMYLAFFEVIGVAWFYGAWRLSKNVKTMTGRHPGYFIKFCWLIATPLMIFALWVFLIIDYEPPTYNNKTYHYPTWAIVLGWIICAFSILCIPITMVIVFLNAPGSTYIEKFKNSIKSDLIDHCPKCSDLDCDCVDDSETGPMLIVKTNADIKPIQNDNKEVPLFTAVSTPNIPQQTEADDVKPSESLSEYDNVQEEKKTNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJT3</accession>
    <name>A0ABM5KJT3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510466.1">
        <property type="nucleotide sequence ID" value="XM_050654509.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654509.1">
        <property type="protein sequence ID" value="XP_050510466.1"/>
        <property type="gene ID" value="LOC126887144"/>
    </dbReference>
    <dbReference type="GeneID" id="126887144"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="312" mass="34914" checksum="2F49879F55B3554C" modified="2025-10-08" version="1">MFAQLFKSCFSTASDPEMDLDCHEKCVIAAKRVICEESREESPVPRKKKRCELFDVVPSVISPAVPEVSGREKRASSEDSIIYVGCETLTPKTIERERLILKVKKNKVVVTPQTITVAAEVHAPPSTSSDYVPVIEDISEPEDGTPVLTYSKPSVEDEILNIADYKWEEIEKPMTEVKVLEKKIISESQPSLNTVVADVLQITNSDEAHHIAFCDDFKGGLVAALERHRDRLKNRLDENTKDSDLLEEAVQNIFSYAKKMMEAFHLEKTRLIVDLNNTKTLLANAVKSDSRDLFSKNAAGDIRRCGMTDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPI1</accession>
    <name>A0ABM5KPI1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512099.1">
        <property type="nucleotide sequence ID" value="XM_050656142.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050512099.1"/>
        <property type="gene ID" value="LOC126888133"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="188" mass="20401" checksum="DFC35D34A342D17B" modified="2025-10-08" version="1">MLNILHFGNLWGLYLQLQSVPKFMAEVVGFSLKEAGALGALPHLMRMIFGTAYGSIGDYLKKNKVMSPKAIRKSFILASHIIPGILMICVIFMGCNWVPLIILLTFSMAINGAAVLTNLQNPQDLAPNFAGSIFGIISCIGGTTGFLVPAITGAFIQKHIWEHLIIGGGQVRRVSRMRKGGGKFLTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPL1</accession>
    <name>A0ABM5KPL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512121.1">
        <property type="nucleotide sequence ID" value="XM_050656164.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656164.1">
        <property type="protein sequence ID" value="XP_050512121.1"/>
        <property type="gene ID" value="LOC114332297"/>
    </dbReference>
    <dbReference type="GeneID" id="114332297"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056978">
        <property type="entry name" value="CC4_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056976">
        <property type="entry name" value="EGF1_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056977">
        <property type="entry name" value="FnI_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056979">
        <property type="entry name" value="FZ_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055110">
        <property type="entry name" value="RECK-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487:SF3">
        <property type="entry name" value="REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23332">
        <property type="entry name" value="CC4_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25027">
        <property type="entry name" value="EGF1_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25028">
        <property type="entry name" value="FnI_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23298">
        <property type="entry name" value="FZ_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22961">
        <property type="entry name" value="RECK-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="627"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="695"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="970" mass="107520" checksum="D92E2F0AF07C7D2B" modified="2025-10-08" version="1">MSTTKTAFGDFRKFRGRNVILYMGFWCCIQGTFAQDLMCCSHATGSCRSICEKISLVDLAADVELRNHTISEVQKYCSSQLNSFWECLNATFKDMSRGDSWSGRMCCPLPHSESCRRACITATSNFDLAKGCRQSDEIAFFSCLERQEAGADCCNNARTDDCKSACVDLFRRELSPTKLQRQKVKDYCENDSPRVTDCVKDLIKVTPVKNIHKHIHCCDKSNIIKCRESCKKVLSTKTTIQEIIDGLQLGGCGLPMPQEYFWQCFLQPDAGSLPNSVKVSRIDKVGIDSAKWHCCQKASSSQCTRLCSKTFTKFWATSWDEFRNKCLSQVSEENLRSCIDEVDEPCELGCDGLSFCTNFNNKPTELFRACTSQADEAARNDVALWQMQNNISLAPGLTLPLKSTTKCSPNIWKAVACTLQIKPCSRTSHANQLCRDVCLDILSQCVDWTRVSPVHSPESICESLSPEDPDDSCVRLQTYLNPSSYKSSRITGQVFSPCKGNPCEADEVCLINRNCIHGINCKPYLCRPGCKLGEVSPYMVPDGTYVRVPTPNSPEGCVKICKCNKNKIEEYKRLLCYPLTPCLLGNTQEPHGAIFHQDCNQCSCYAGETICSKKQCESTSLSGRNTAYTTLPCNCPPHYVPVCGRNGITYPSTCLAKCADLNDADIEHYPCQNPCKANSCPVGQKCVPDPQVCLSLMHKPCNQYECINGSSNCSYLPKDPVCDIDNQEYENSCLLAHHNAKLAYRGRCLTKCKHRSQVCGFNGKTYISECAAFADMVAVDYEGPCVAMGLITNIKSKQCLGVKCPELQNSNCIGITPPGACCPICGGAMRLLYSRKQIDRALFALQNHTTKPLNLRSVLEALERQIQVAQCTLKGYLSVELDIFVIVHSTERNPSDLQLEACIREAEKIASLINIQSPRIVSELSLSSLTAASIVHTQMSSSVNNHVNNLRLSILAVILVGFLQKIVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQG6</accession>
    <name>A0ABM5KQG6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512430.1">
        <property type="nucleotide sequence ID" value="XM_050656473.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656473.1">
        <property type="protein sequence ID" value="XP_050512430.1"/>
        <property type="gene ID" value="LOC126888329"/>
    </dbReference>
    <dbReference type="GeneID" id="126888329"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046335429" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1398"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1631" mass="165497" checksum="4C325953650FB7BD" modified="2025-10-08" version="1">MRSKFFCVIFVIFYNFPLYRQDSIENNTILKQNVSTTETPIKSRLLYDYQTHAVAFKDLIESKCILEILSGNDSVITKWNLNGRRGSISKDFLHNELLSKRQIWRLAGDRITEFCRGFPTYLIKNNADLTENQEIILNDLPNYIIKNRRKRTTSHYFQGRVRGQTQSQYLNFGKSDEPGKAEAESTYEGSKAVVSGSNGMGQAQSQSLPFGCDECYGRDQDQTIELQRLPGGRIPEAIIQRPGGTDTIGKPGWTGGSGHGEPELTGRPGQATGPGQVGGWTGQTGRPGQVGGSGSTGGGQYGGGPSQPNMPSRGTGRDGWPGQSEGGGQTGGWPEQSGGWPGQTSGIRQPSGMRQPVETGQPGIIGQPGGYGQPSGTNQPGGIGQPGGYGQPGGTGQPIETGQPGVIGQPGGYGQPNGARQPGGIGQPGGYGQPAGTGQPVGTGQPGIIGQPGGYGPPSGTGYPGGTLQPGGYRQPGSPGQSGEIAPPRKIEQPGGIQQPGGIGQSGGYPGRPGEIPQTNEWPGQAGGIPQPGRWPSQTTGQTGTNGQRGPGPVGGVDQNGIPIESWPANVGEKPGSVGDWPGQQWPSHVGGSAPGGTQPSVPLGTTGQDQGPRQTGGWPGSTGPQPPSQVGTTGQGQGPRQTSGWPGSTDSRNPPLIRPDQSGGSGPTIGQISKYPYGTGVFGGKLSGDYQGQQGNYGRFSGQFSGQYEAYGPQGPPRPGELGYGQPGQLRYPEISSTPPTGRPGQAGTGTRPDQASGPGQTGGWPGQTGGWPGQTGGWPGQTGGWPGQTGGWPGPIGSPGQIGSPGQTGGWQGQVGSPGQSGGWPGQGLGPGVTGGTNGPISSWPSPVGSPGQGGNWPSPGIPGNVDGRPNTGWPGNLLTPGQVPGPVQSGGWPGQNGGSLPGPGQIGTTGQTGGWAQTPPSGTAGGGIQTGNLPDQGGNVGPGGGSPTGGLPSPVGVPGQNIGWPGQTGTQVSGYPGQNGQSGAWPGQEGGTNHPGWSGQPSGTGQLGGWPGQVGTQGGGQGGSTGAPGLTPGQTVGAGQDGGWPGHVGAPGQTGGGAGQVGGWPGHLGAPGQTGGWPGQVGTPGQTGGWPSQSGPGSFVTVPGQTGGGTGNVPGLIGGPGQAVGGQISAVESDDSDSQVQTSVQHTENGTTAEAQAQGVFGGGTAQSQVSGTYSGSGSFSASAGSDDGKRGAQTQVSGAKEGAQSSAQGRGGVGQSQSQVVFSHETGQTSSSAQSGGITHGTQSQVQASEKGGLADAQSNGPGSTSSQAQIGFLPYDENDADNGTESFMGGGTAGAQSGTHSGMSQSQVQGRFKYGVKYTGAAQAASGGTGFGKNFTKTGPFNPTEIDFKVAREKLSQKQVQRATTVSKTNSKSVPIPDEPSPSTTVKAPINAKKLNSNSNQSNKKDYDDEYYDDYEDETEKPKTRSIITQSDHNQRQHIILDPLEDLDLTVHQSKGELLNEATVIQPGETVPGIPGYKIPLGFRGTVKSIANGPNTYAIGKNSHAQSVTLSPGSGKIIYKKPFYAVTSNTHSTNGQYGYGSGYTYQPAYSPVKYQLKSGKTLPNFVSMTKSETGSRNLYTGKKTPSVYYTQSSTCGIFTNQCIFNAGRKLCFPKAKTNPDGTIMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQR8</accession>
    <name>A0ABM5KQR8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512535.1">
        <property type="nucleotide sequence ID" value="XM_050656578.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656578.1">
        <property type="protein sequence ID" value="XP_050512535.1"/>
        <property type="gene ID" value="LOC114330753"/>
    </dbReference>
    <dbReference type="GeneID" id="114330753"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057401">
        <property type="entry name" value="Adt-1/2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF275">
        <property type="entry name" value="STALL, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25379">
        <property type="entry name" value="Adt-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046214483" description="Peptidase M12B domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="12">
        <location>
            <begin position="250"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="992" mass="111485" checksum="CDC815AEDA11FF39" modified="2025-10-08" version="1">MRGALRCFLITCLLINIGFSYEVTKARLKELLTPLEWSSLLQNTNSDENYSIIYPTIHLHDEEITSKETQIENEVQYKIHRILIKSKELGKNFDIYLKPSNKELVAGDIVILETYANGSRPLEVNEEDKNCYFRNENVALSLCKGIRGILHTSEKEYFLIHPLPDRFQNETSKPHILIKKSHFLHNAKDGSCLHNIDDNSTLPLLNQAKDISDNDIIDEEFEAQLEDGILAHSHRKSRRKREVFPDGSPAFVETAVFVDKDLFEHMKTNFPYETEREVIRFVLAMINAVQLLYHDPSLGRPVNFVLKRLEILKEEVSGLVRPSDIDRFLSNFCNWQRTKNPTGDNQPLHWDHALILTGLDLYVRGKHGKISNQVVGLAPVAGMCTATSSCTVNEGRHFESVYVVAHEIGHNLGMRHDGPLAENDCDPSTYIMSPTLGSGKITWSTCSKRYLQKFLDTPQSRCLLDHSSSAGKLDHSAEGALPGERFDANQQCMLKYGKGSKHSAQQPLNDVCRDLHCERERYTWTSHPALEGTVCGNNMWCRGGKCVAKGLVLSAAYTAQSSARLGQINGGWSKWKHSSDCASGCLFGEEGRLKSGSTGIMVSERICNNPRPQGAGAECEGPTIRHSTCVAEQCANVPRLTIREFADQICTRAKEVDNDLTGSGMQKISSDAEEACLVWCQKRNGSTRSRGWTFPDGTTCQIRRNRYGKSSYCIKGRCEEFVCDPMEEAAFAQAADLCPIDRYDNELNWRTGLRRREGAIRWKSASGCHYNCISPGSGIRLVKNKKYNRSSIQLCQPDKFGCSRVKSPFQHASLICTKYKERVRRLSGLGMQISPAVEDPDRSCRVACQDALISHRFYLVNGEDGWFPFGTDCSKGMPANKKAYCVSGKCLEFGTDDTPVSESEFTLALLSRAKRSLYDNNNSTKITMKLNQMELDNIIKDLHRTLAGNLSSNGINQFNIDLNNPVHISINSEQDFHPHVSFTSSDEYINYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT83</accession>
    <name>A0ABM5KT83_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein takeout-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513386.1">
        <property type="nucleotide sequence ID" value="XM_050657429.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657429.1">
        <property type="protein sequence ID" value="XP_050513386.1"/>
        <property type="gene ID" value="LOC114332812"/>
    </dbReference>
    <dbReference type="GeneID" id="114332812"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354696" description="Protein takeout-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27996" checksum="035F3AC0CCC4E02E" modified="2025-10-08" version="1">MNGKFFFCFLLNLFVAGVISHKFTIPSYIKPCSISAPNFEKCCLEHGKEALPRILKGDRKFGIPNMIPLLIPQINVNAGQGLRIFLKDVQVHGLDTTELIKVKIDTKAQKLSIRIKIPELKLLGKYDIEGKILVLRIEGNGDFNIVAFNGEYEYNANFLLHNIGGEDFFDLADKDTLDFVVKDLKVHLDNLFNGDKALGDQMNKFLNENWEAVIKEFGPAISETVRSIGRSIASAIFKRIPYHQLILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KTJ6</accession>
    <name>A0ABM5KTJ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513512.1">
        <property type="nucleotide sequence ID" value="XM_050657555.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657555.1">
        <property type="protein sequence ID" value="XP_050513512.1"/>
        <property type="gene ID" value="LOC126889325"/>
    </dbReference>
    <dbReference type="GeneID" id="126889325"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="402"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="903" mass="104783" checksum="3F0BCC50184844FD" modified="2025-10-08" version="1">MDSHMQPIQYLNNARLATLLHRYKELNIKKMLQKSKIFYNNECLRLNLLPSYARGRLRELNFNATKAKQVKILGRSIIRDEIRKLYQHIYTIDLQLKTIYNSLHRRMTALEFDECMRDLHGTINFHRSRQYRKLHDKIKKLKFITHRVNNNIILSNQSVFSQLNNDQLVVDSNSNGSYIVTPSNFTNSDLYTSERLLNVTTNTSLSDLPDQTHSINTSISSDPDNIFDGSEQHTFYTPFINYSNVVFSNNELSLLQKGFKFNPPQSSKKQQLRNLELLGVESESILQSIPLENTEEIRSSLKVLLKKEKEAICNNRKGYHRNPLNEYKDTIKSIDKKISENNLTVTKADKGSTVVVLHTQDYHQKVTNFILDNQFLTKSVNINTFTTKVRTAINKITEVFDNTTKKKLLPSKANVPRLYGLMKIHKTDVFENIPIRPVVSFTDSPTHALASHLNKFLKTFYNNKFDYVVSNNLSLTNKITEVNLSNEDLLISLDITNLFTNIPTQEVISIVALDLWNNNYHPNQIIEYTELLNLCLSQNFFNFNNTTYVQPDGLAMGSPLSPILADIFLNDLESNKIVKNNPFTDYIKFYARYVDDTLIIWNGTIDILHDFLDFLNTLHDTIKFTLEIQNDSKSLNFLDLTLTLRNGTIDFGIYRKPTHTGTVIPADSHHPIQHKLAAFYSYINRLVSIPLTTTSFNKELKIIQQIAVNNGYTVDLVNKILHKKTNRILEHRVYTQPILVEQEPKPYRSLTFTGQFSYKLAHIFKYYCNISFRTNSNLGLVFLNNKDSRDRSECCGVYELKCHTCSSYYVGRTFRSFDTRLKEHLRYIQRPTSGQSHFSQHIRNSNHNFNPDIDFKILHICKKGHVLNNLEHFEILKSLKDPTRHTLNAQLELEFIPAYSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV65</accession>
    <name>A0ABM5KV65_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514079.1">
        <property type="nucleotide sequence ID" value="XM_050658122.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658122.1">
        <property type="protein sequence ID" value="XP_050514079.1"/>
        <property type="gene ID" value="LOC114342596"/>
    </dbReference>
    <dbReference type="GeneID" id="114342596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="227" mass="24809" checksum="A8ED182D62BAB732" modified="2025-10-08" version="1">MAQNNLSIWGWALIIIAAGLALTIRYFCIYYCRMFCRVCCDSLCTTTEDGPSVTVTTTTQHAQSPQVVPPYPIDTRHPVPASNITGYGNQAPYQQYPFHQTVPQPYGLPPPAMGMAGTSFYTGHIRQLSYPGQFSTWSPACRPMSMTIPSAVPTPTHTTVPYFQTGNVASPMAGATPYPPQPYQQAAHDYSANPPPYDVAVSQPPLQPPPNSKEGYVKQSPYNPGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWX3</accession>
    <name>A0ABM5KWX3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger MYM-type protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514685.1">
        <property type="nucleotide sequence ID" value="XM_050658728.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658728.1">
        <property type="protein sequence ID" value="XP_050514685.1"/>
        <property type="gene ID" value="LOC126889957"/>
    </dbReference>
    <dbReference type="GeneID" id="126889957"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58308" checksum="ADF87C6DAE979DE9" modified="2025-10-08" version="1">MYADSKIAKNVKCGRTKSEAIVCEVLAKEALKDVVQNLKEDLFFSISTDASNKGNRKMFPICVRYFSFDKGIQNKLIDFVESNDETADQITKVLCETLDKHNLKLSQVTSYGADNANVNFGSNHSVFTNLHYKNEKILKANCSVHILHNMSKFACDRLDIDVEAIILKIYGHFSHSAKRRAELMEIFETTEMEWVELLRHVNTRFLSLCPAVERIIKVWPALKSYFDKKESCAKAIEKIFGSEAEETKTLAYLNFVYNVMSAFGTLIKESQGNDIAITEMHESLCLFRSRLIQRQKDGFFGYQTKLILNKLVESEEIKVIEDFKLFYTNCQKYIEKRYNFSDENIFARLKFLNLETEISFDMIENAIALLKLTDNISVDHLYEEFNLLKSSLDVLVGNSKDTTATTAQKWQQLFQQFPKKDTRNMFKLVSFILSTPTSNCFPERVFSQMNLKWSDARNKCSVKLIKAELLVQFNLQLSCEEFFKFTKEKRDILKEVKSSQKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX52</accession>
    <name>A0ABM5KX52_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502408.1">
        <property type="nucleotide sequence ID" value="XM_050646451.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514765.1">
        <property type="nucleotide sequence ID" value="XM_050658808.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517277.1">
        <property type="nucleotide sequence ID" value="XM_050661320.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519087.1">
        <property type="nucleotide sequence ID" value="XM_050663130.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646451.1">
        <property type="protein sequence ID" value="XP_050502408.1"/>
        <property type="gene ID" value="LOC126881842"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658808.1">
        <property type="protein sequence ID" value="XP_050514765.1"/>
        <property type="gene ID" value="LOC126890008"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661320.1">
        <property type="protein sequence ID" value="XP_050517277.1"/>
        <property type="gene ID" value="LOC126891962"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663130.1">
        <property type="protein sequence ID" value="XP_050519087.1"/>
        <property type="gene ID" value="LOC126893175"/>
    </dbReference>
    <dbReference type="GeneID" id="126881842"/>
    <dbReference type="GeneID" id="126890008"/>
    <dbReference type="GeneID" id="126891962"/>
    <dbReference type="GeneID" id="126893175"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="261" mass="29699" checksum="8A02AD320D775F27" modified="2025-10-08" version="1">MALIGNIEAFTGVPEEFESYIERLEHLFTVNKVEENMKVSMLITLGGTSLFQVLKNLVAPKKPTEFTFQEVKGKLIKHFSPPVSEIYERFVFNRCEQKADQSISDYSVELRKLANSCNFGQFLEEALRDRFVCGIRDEGTQKKLLGDVDLTFQSACQLALASEVAQKQVKLLSEGGNINVLNRGKHRNPKFRSTLSADQSCKNCGRSHHRGKCPAEKWRCFFCAKFGHVKNFCPDIRPQPVNVVQEEEYNIDSDEVNLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ40</accession>
    <name>A0ABM5KZ40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515454.1">
        <property type="nucleotide sequence ID" value="XM_050659497.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659497.1">
        <property type="protein sequence ID" value="XP_050515454.1"/>
        <property type="gene ID" value="LOC126890506"/>
    </dbReference>
    <dbReference type="GeneID" id="126890506"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67805" checksum="F88CC2F2C0A6EC91" modified="2025-10-08" version="1">MQVTPINFKKNSYDLHGELKRWAIRNKVTHSTVTDLLHVLVPVHPELPLSSKTLLNTPTIITLKKELTSGSYVHFGLENYLKFYISTNDSIISNDILISFNIDGLPLFKSSSVQFWPILGLIVNSSIKVKPFAIGVFCGNSKPSPLADYLNDFINDLKFLLENGLTFKDKEYRIHVHSFICDAPARAFIKCIKSHNGYSGCDKCTEEGDYFKHRMIFNNILAPRRSDQSFLLKSDQNHHTGISPLEVLNIGLVSKFPIDSMHCLYLGVMKKLLLTWICGDLRVRLCGRDVTNISENLIFYGKFVVSEFNRKPRSLSEVARFKATEFRTLLLYLGVLVLKNIDKAMYEHFLLLHSSVSILLSKRHLANFGCDVPRKLLDCFITHSKDLYGLEFLIYNVHVLCHLSEEARLFGPLDQISAFPFENYLNEIKKSVKSPNKPLEQLFCRLTEANTISVINDSVTKKCEIQHFNGPLLHLSFNSTKQYNKLKYNNIVYTVEAHSNVNCYCLNNEYCVIKINNIVNAKNEYFLIGQKFTSYESFYNYPFESKSLNICIVSKLLQNMELFNLDSIITKCMLFPLDPPNNSKWLSFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L066</accession>
    <name>A0ABM5L066_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515825.1">
        <property type="nucleotide sequence ID" value="XM_050659868.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659868.1">
        <property type="protein sequence ID" value="XP_050515825.1"/>
        <property type="gene ID" value="LOC126890702"/>
    </dbReference>
    <dbReference type="GeneID" id="126890702"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20818" checksum="2886FA0AF77A92B2" modified="2025-10-08" version="1">MAPTPPTCEDTRKVSPNLFQELSSDETDGYTSMDDRSAKNDGFKLPRSEKKKEKSIKKREEKKKESDEKNQTEETKKDKDNPKVEAMEEEVPDEAGRGTTKRAQTAKSESEEDPNEEVATLRKVIKTMSARFQIAEDQMAKKEEENERLRAEIKKMSNRYYLFYHFMVITFVKWWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0K0</accession>
    <name>A0ABM5L0K0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050515966.1">
        <property type="nucleotide sequence ID" value="XM_050660009.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515967.1">
        <property type="nucleotide sequence ID" value="XM_050660010.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660009.1">
        <property type="protein sequence ID" value="XP_050515966.1"/>
        <property type="gene ID" value="LOC126890817"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660010.1">
        <property type="protein sequence ID" value="XP_050515967.1"/>
        <property type="gene ID" value="LOC126890817"/>
    </dbReference>
    <dbReference type="GeneID" id="126890817"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="130"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="384" mass="43680" checksum="555AD048699CEF78" modified="2025-10-08" version="1">MGNWLSSSVPSSVHTIITTPTLNLSNNRTQILSKSALHRASIPAKFFTDRASSCSKAVTDNTTRIPGYSAPSFKTNQESSRIRPDNHKTLTSSKDQSSSSRTINQHSRINTNRKTPIPVRKNPEILSISNTLYNSNINLTENVFQLEILSEDSCEYDRMKSKFFQSNRSFFKLHSIEKVHNPYLLLQYGLKKSEYDRRGISYKETLLFHGTKKVNIEDICETNFDWRLHGSAFGSRFGQGVNFASEAYFSTHYCDHGYNKVMIMVNVLIGNSCRGNRDMAIPPINCDTSTNGKQNVYVKYDDNTFYPAYIIHFGGIHCKKKNRLNISQYDYDRNSDCTSDRDSDCTSDRDSECTSDRISDSTSDRDSDWVSDCYSDCDSDCDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1I8</accession>
    <name>A0ABM5L1I8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN-DOC-like zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516310.1">
        <property type="nucleotide sequence ID" value="XM_050660353.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660353.1">
        <property type="protein sequence ID" value="XP_050516310.1"/>
        <property type="gene ID" value="LOC126891171"/>
    </dbReference>
    <dbReference type="GeneID" id="126891171"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="566" mass="65179" checksum="455261DDE1272C3F" modified="2025-10-08" version="1">MEKKRKIDSECRKFKDQWNIQYFVIESSNKALCLICNESIAVLKEYNMKRHYETKHSQNYSKYTGIVRTEKFEALKCGLKSQQSLFTKVKTEQEAATRASFRVALEIAKRGKPFTDGEMIKECIIAVVEEMCPEKVNLLKTVSMSANTVARRVQNIAENISSQLFDKNGHVEWFSLALDESTDVSDTAQVLIYIRGVDKSYEVHEELLDMYSIHGTTTGIDIFKGVEMAINKKNLRWKNLKCITTDGGKNMSGKDKGVVALVSKAVENDGGSKPLVLHCIIHQQSLCGKCLDMSDVLKPVISTVNFIRSFGLNHRQFRQFIAEIGETDLPYHTAVRWLSCGKVLQRFFELRAVIEIFLNEKHRPLTELQNNAWLWKLAFYVDLTKHVNELNLRLQGENQHLPDLYTNIKSFRMKLILFQSQLRSKCFSHFKTCEIFSQTTETEFPIDFAIETLSALKINFDTRFWAFDAIANQIKIFQNPFDADIETLAPELQMEMIDLQCSDIIKNKYENSSLLQFYKSLPLTQFDNLHKFARGLFSVFGTTYRKRTDRLTAINSSHKVATNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1L7</accession>
    <name>A0ABM5L1L7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516329.1">
        <property type="nucleotide sequence ID" value="XM_050660372.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660372.1">
        <property type="protein sequence ID" value="XP_050516329.1"/>
        <property type="gene ID" value="LOC126891189"/>
    </dbReference>
    <dbReference type="GeneID" id="126891189"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1288" mass="150111" checksum="6D41539B4037FAC0" modified="2025-10-08" version="1">MLAKLIHLIGTILELISDNYNVEKLRKGLVECKKAIKMIHDRMRFAKTIGEKHHLEAQMRQVKTLRNQLKAEQKKGAGLKTLPETAKRRVQWDDSVSTFNSRIQTGVISNLKHKDPGSFLVDCKALFKRRIHNVLKNNAAVKVNIAFGGEFEIAQGEKMINETKYFTTSNSAIYRDTNLDEWFKKKVVEPISRDLEEFQERDSGWALKSVVNLGVNINKFTPQLDSSYIELPPQIKRKQACINVKNDDEACFAWAVISALYPCRSNSDLMSSYPHYSQVLKLKGIQWPMTFKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTKNKKDKHVNMLLIQDNYDDQGPVRYHYVWIKNLSRLLSKQLSKCDGTKYFCDGCLHYFRSQEKMNKTCCNGRSDVICDRCLQPFSSYTQLEAHINDCERINETAIKMPEESQKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVGYYFKCSYDNSLSFYKSYRGKDCMKWFADELNQLAEDVYTVFMCPFDINMTFQQESDFQSATHCHICEQRFSPSDKKIRDHNHLIPENNYRFAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVTDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSKYVFLPEEQFNLLTAKGVMPYDYIDSFDRFIETCLPSIESFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLADVFERFRSSCLETYNLDPAHYFTLPGFTWDAMLKYTKEELELLTDPDMHLFVERGIRGGLSQVCSKRRVHANNKYMVSYDPSKTDSYLMYFDVNNQYGWAMSQYLPFGGFEWTDTNIDVLSIPDDSSEGCILEVDLEYPQHLHDRHKDIPFCPQSLNPKTMKPPKRPRELTKLMATLHDKERYVIHYRALKQALAHGLILKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTLECVRRRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLIAVEMHRAEIWLVKPIYVGMSILDLAKTTIYDFQYGYLASRFGENFSTCYTDTDSVIVEIREKDPYEAMIYDCYKYFDTSDYPKDNIYNIPLVNKKVLGIMKDENNGCIMTDYIGLRSKLYTTKAATTDNDIEKLRGKLKEQEYEDDEIDNIIRNYGVTKKAKGVKKSVVNTKITFEDYVECLDTFTTKTATQNLIRSDKHQVYSITQSKIALSSNDDKRQHIQGSYDTLPFGHYLIDTLEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1U8</accession>
    <name>A0ABM5L1U8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516410.1">
        <property type="nucleotide sequence ID" value="XM_050660453.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660453.1">
        <property type="protein sequence ID" value="XP_050516410.1"/>
        <property type="gene ID" value="LOC126891274"/>
    </dbReference>
    <dbReference type="GeneID" id="126891274"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="414" mass="47811" checksum="702F02562C2E23F5" modified="2025-10-08" version="1">MTTVYENQEHSDSVVMPPIFDIYRKPMFDESIRKAEYRTYAPFIKSFNCNDIVEFSINQVDSFFEMSETLLCIKGSLVDKAGSGTITLANNVGAFLFDSCTYSESAREMETVRDPGIVSAVRAMTCYNQEDSKYMVMAGWNNPNNPILNDTSFNIQMPLKHIFNIFNDYPMITCGRQTIRLVRARNDNDCLIITDAATTVKINITNIELRVKHIYPNDEIKLQLMTSIQEDRPIVIPFRKWELHELPTITKGARREVWAVKTSTSVERPRYVLVFFQTGKRNTIKADPTLFDNVSIQSIRLSLNGEYFPNERMQLDFSKTDYNEAYFNYTEFHPRYAHSTQKRPLLDFSAFQHHALFVIDCSKQEESMKASTVDVKLDIEANNGFPDNTKAYCIIIHDCVMEYFPLTEIVKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1Z3</accession>
    <name>A0ABM5L1Z3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516455.1">
        <property type="nucleotide sequence ID" value="XM_050660498.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660498.1">
        <property type="protein sequence ID" value="XP_050516455.1"/>
        <property type="gene ID" value="LOC126891321"/>
    </dbReference>
    <dbReference type="GeneID" id="126891321"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047316282" description="Peptidase metallopeptidase domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="12">
        <location>
            <begin position="88"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="447"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="515" mass="58922" checksum="3532476B3AEAE5C0" modified="2025-10-08" version="1">MHINKVVLLIATSISFCLGGNFTETNAVSWLEQYGYITTSETANTDITETLEQFQERYNLPVDGKLNKETMELMQKPRCTQGDNAYAVKSAWKKFDIKWYFPQAIPEALTVTKRVFEIWEEASKFKFTYLRIPNPQPDITITVVPKQHYFRYNCQGNDECPFKFTNGVLAHSYFPPTSGCIEIHMNSNLTWDFSLNSTVEGRTNFFAVLLHEVGHALGLAHSSDKKAVMYPFYETFPSHITDDDKRGLEKLYGPKSKSASIPTRPGVTRSSVPTLKTTTTERSWSTTTTAARTNKSKQNIITNVCELEYPDLIFLAYAPSFPTYRMYIVSKDLVWKYDLNNEKIPTNAEQFIRYFPRGITNVTHVFQSTNGDLIGVSRNRIYAAAFPSLRIHTDNMVPEVNNARSINGLFQTNSGKKFVCFDGSFIEFNDKDIISRGRISDVFPGIPNDITSAFNYIDGHIYFLKQNIYYKFNEFTRSVVEKGTFNWNMLGFPCPDNGLIKQLKSLLSKVNLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2I3</accession>
    <name>A0ABM5L2I3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516647.1">
        <property type="nucleotide sequence ID" value="XM_050660690.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660690.1">
        <property type="protein sequence ID" value="XP_050516647.1"/>
        <property type="gene ID" value="LOC126891511"/>
    </dbReference>
    <dbReference type="GeneID" id="126891511"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="266" mass="31936" checksum="751A3F555F0BA231" modified="2025-10-08" version="1">MKRSRNEHNSSQEEQEFLRESKLVARSPQHKEKVKQPEPSMDEIKQMLRDLKKDLHEDMAQIKREIQNDIREMREDIKDTKKELQKNREEMKSMAKEITQMKEEWTREKEELHNKIKEVEDKMERMEKQKIRNDLTITGLPTNTDNEDTLEEALEKMFQTELLLKTKIRRAQKIGQDRCIVEMVEWNDKIKILQGKAKLKGKDIFIDSELTRNEQKIQKKIRDIAREEKKKGAIVKVGYQKLEVNGKKMKWDHRSQKLTEANKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L304</accession>
    <name>A0ABM5L304_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516826.1">
        <property type="nucleotide sequence ID" value="XM_050660869.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660869.1">
        <property type="protein sequence ID" value="XP_050516826.1"/>
        <property type="gene ID" value="LOC126891645"/>
    </dbReference>
    <dbReference type="GeneID" id="126891645"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="70"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="356" mass="40903" checksum="1FBAA9E89A8AF959" modified="2025-10-08" version="1">MEYLKKPELVAKVQKYFGVNTKHIQKDKEYTIENKFWYYLFVFGTALGDETFYSAFIPFWFWNIDGAVGRRVVLVWTIVMYIGQGIKDIIQWPRPGPPXWALEYGMPSTHAMVGVSIPFSVLLYTMGRYQYNVPLGMCIAVLWCTLISISRLYLGMHTVLDVIVGLALAVLIMFPIVPLVDLFDNYLLTSPTSPILLLVSSILLIFYYPNSGKWTPTRGDTTMILSVCVGIQIGSWLNFHSGLMTPSELTPPYIIMWPSYTMFGCLLLRTFIGFVTVLLTKKVFTSITYNFLCAILRQDVNNLKKSENTLQNKHKTFVELSCKYVFCAMIGFNAVYVLPQLFRFLRIERPTFFTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L425</accession>
    <name>A0ABM5L425_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517189.1">
        <property type="nucleotide sequence ID" value="XM_050661232.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661232.1">
        <property type="protein sequence ID" value="XP_050517189.1"/>
        <property type="gene ID" value="LOC126891892"/>
    </dbReference>
    <dbReference type="GeneID" id="126891892"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="886" mass="102393" checksum="B4339AFBE331FF63" modified="2025-10-08" version="1">MIKKKKQDHLKPKANILLEPDVKLNDNIDNDSQPLNKTLDLYEFQENDLEEKASKSPEYDKLEEKTYTPLKAVNFDCYPILTKIDTNLNTDHRDYEDNEDFSESRDTSSYVPETEIESEGGEEEIIIPIFKTINVTCPESTLTKDEPSEKPHISNIETNNSIVALSHRKNRVWDRKNFCPICFVEVSHFARHLERNHADESRVKKILSFPKGSNERKTLWDSLRKEGNFHLFREEKKVVAVRRPTEAQALDFDDFVVCENCSGVYKKKFFYKHAKKCQEKHTGTKCGRLNALTQSQTFLAASRCQNSFLSQSRLKKEVFCIMKADKISATAKNDILICLFGETHLKKHKRKQIVTVTSNKMRELARLLIALREFTPVQNLIDAMKPELFDDLVKATKVISGFSNADKSFKSSSLALHMGTTLKQVCDIINRMILKKSPLFTFKNPNEEKKSIRDLKTLLETSWANEISSLALKTMKEQQWEKPQILPVTSDVIKFNNFVKNQVEDSAKKLNKLLEKEGKQNDKNDLLPLYKTLAKGIMALLLILNRKRIGEIQYLEISTYKRSFAEPSVQKEIAESLTVSEKLLCRNFRRIITGGKGSKPVAILISPFLNEKIELMIKIREKIKLIPEDNKYIFANPNSSKGWFHGTSVIKQFATNCGAKDPNSLTSTKFRKQTATILQIMDINNTDMEQLAIFMGHTKKTHEEWYRLPQDLYQTAKIAKLMIALNKGDVNIYKGKSLDDINIEENDYLEIENIETEVNEINEKELTEPTHSWSPKSNFSDVTDEKIEQANKNEKVSSKGKRKLFTDEMTHPMQNNKVTKRKEVPTTEKTESTSNAIARHRWTEKDKQTMLKYFTRFIKEKRVPKKADVQKFKKIKLEKTFNQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L631</accession>
    <name>A0ABM5L631_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517895.1">
        <property type="nucleotide sequence ID" value="XM_050661938.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661938.1">
        <property type="protein sequence ID" value="XP_050517895.1"/>
        <property type="gene ID" value="LOC126892410"/>
    </dbReference>
    <dbReference type="GeneID" id="126892410"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047123155" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="281" mass="31473" checksum="642472CC8E4282FF" modified="2025-10-08" version="1">MSFTFMNFILLIFFGSLLIVYCRADDQCNAIWPPCNNIENIVCRNGGSCDPARNSQCKPLKNDDSFRVWIVDLHNRYRNNIASGNDTRNGASSAANMQVMNYDFDLEYTASCTANTCTGEADDCGRTLNFWQNGQSIEIVDGGEDALMDIPHQWYQRIESMGPKGFDNFREDLPLAFTQMIWANTTNVGCAKAHSTTQNRSILVCNYGPPGNIYGEKIFERGEPASKCPDGSVRSMYYDSLCGTVLPLELIRPRSAYNGVSKSIYHSLMTIICAQLLYLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6H7</accession>
    <name>A0ABM5L6H7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extensin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518044.1">
        <property type="nucleotide sequence ID" value="XM_050662087.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662087.1">
        <property type="protein sequence ID" value="XP_050518044.1"/>
        <property type="gene ID" value="LOC126892528"/>
    </dbReference>
    <dbReference type="GeneID" id="126892528"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046927422" description="Extensin-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49039" checksum="D20FFAC13E519C32" modified="2025-10-08" version="1">MSIKIPAVLCCLTAAAFAAIAPGENAYLPPKKGYEYPVPPIPFPSRPPIATLPPTAPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPYRPPVTQPPKPTYGPPYRPPVGPPVTQPTPRPTYGPPIPGTPPTRGPIVPFKPGGPIPGNGPEDHLKLPHKPAEPFQFNYEVKEPSYGNDYSHNAINNGDQTNGEYRVQLPDGRTQVVKYTADWATGFHAKISYEGTPNYPSFPNNRTPAPRPAPGPGPGYPSVRPPSPGFPSIPTRPTPSYPSPSPGYPRPSPSYPSPSPSYPRPTPSYPSPSPSYPRPTPSYPSPSPSYPRPTPSYPSPSPSYPRPTPSYPGPSPSYPGPSPGPGYPSGRPTGPPFPTPGGRPGPGYLPPDNRQKYSPGGGYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L899</accession>
    <name>A0ABM5L899_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein SmydA-8-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518659.1">
        <property type="nucleotide sequence ID" value="XM_050662702.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662702.1">
        <property type="protein sequence ID" value="XP_050518659.1"/>
        <property type="gene ID" value="LOC114329010"/>
    </dbReference>
    <dbReference type="GeneID" id="114329010"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="102"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="72831" checksum="702604C2ECD2DE09" modified="2025-10-08" version="1">MEMTEFEKSVILKQLAKEKKIANSTFTFTEEYDNEFDAFAKYYAAIKSNGFISKILQEIDLMRDPCQLFEKVSKKSQYQQLDLHYEDLAISNRNQNICYATDMVELQTTAESGRHLIAAQNLCTNTVLINEIPTVLQVTPLCKCLGNEATSLYRCHHCGIGCGTFYTCVTCNLCIFCSRTCYEIAYEEYHAYECDGVQRHFWPIWDDTDYSYLSLRMMLYGASRDFDASSGSSFYGNSSNNYPYIYDLETHFRDMSTEQINKVLYSSAKNLLYLINKSNFFTKFKHKGCMDKFSLYIGGLMVKHYCQAQINNVLLTFPNLNLASGLNTMSGTGKAICPTIALINHACNPNATIIVYAHYIVVKTIRPIRQGEEITLCYSEINGFLPLEDRRLVTQHFLFFTCRCLICELEEAANERPFKCPSCENTAIKEIEMGVRKCSGFCALCHRSVNMNHISREMKNVSKYRKLYYSSFSIEHLEKIAECYKTIFPPNSLQLLDIYNILYEKHLLWGGNEHPMERLKYGLLIFEIIETIFSRLYPPLLAGKLLFLVNVFETVEGITQNRDIPPEEFELLKKYVKEVFQIKNDLLFYLPLDKISYYVTLQSKVKIEFDWVIEIIKLISSYEAKIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L997</accession>
    <name>A0ABM5L997_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519010.1">
        <property type="nucleotide sequence ID" value="XM_050663053.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663053.1">
        <property type="protein sequence ID" value="XP_050519010.1"/>
        <property type="gene ID" value="LOC126893107"/>
    </dbReference>
    <dbReference type="GeneID" id="126893107"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="34643" checksum="41B0D5EBF737AEA5" modified="2025-10-08" version="1">MSQGRKGLRNKKNEQDVEVEENVEVHGETQQAEQEQSVAQVLQETTGITQEQEENVNMTALMSLMMQINKKLEENSKEIKEDMKKMEYNMEENLNMVDYALKLITVAKYLEPPLREDETVLNVSRHFDADVVQTVTVQNIQTVDSFINFIQRVQRGYITSNNSKNRQSYNNNRYGSNSQNFNNNNNTSYERQGNRENFNNNTNDNRQERQGNRENFNNNNNYNRQDFNTRRNAQRYNYNRQVNYVRGQSCEDSQRNSTWQENMNSRSESSERHRELDPNDQTQSDNPNNPNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9B9</accession>
    <name>A0ABM5L9B9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519033.1">
        <property type="nucleotide sequence ID" value="XM_050663076.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663076.1">
        <property type="protein sequence ID" value="XP_050519033.1"/>
        <property type="gene ID" value="LOC126893128"/>
    </dbReference>
    <dbReference type="GeneID" id="126893128"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15809" checksum="DA7EDCA2104CDFF4" modified="2025-10-08" version="1">MVLLATVDANYRFTTVDVGSMGRFSDGNIFANSPLGKLLSSGSMDLPEPKSLPGQDTLTPYVFIGDEAFPLMPHLMRPYPKVRVTNNYENKVFNYRLSRGRQTVECAFGILAARFRVYNRPFECKSETIDKVVLASYHCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9N0</accession>
    <name>A0ABM5L9N0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519140.1">
        <property type="nucleotide sequence ID" value="XM_050663183.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663183.1">
        <property type="protein sequence ID" value="XP_050519140.1"/>
        <property type="gene ID" value="LOC126893214"/>
    </dbReference>
    <dbReference type="GeneID" id="126893214"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="262" mass="29782" checksum="4C43992D070C9BBE" modified="2025-10-08" version="1">MSDKLTKANLKRTTAFKRLQETYECGLKVSNDESLKPEFLARANAIDGTYNEFQSNHNTVISLINDDEFSSYDEMRLNADKAFYGVLSLKHDFLLNNSSSQAANMSTVDNSNSSNRRSVVNLPKLSLMRFEGSYKDFPTYFDVFNSLIHNNPDISNVEKFQYLLTSLGNEPLALIKGIPLTEGNYTVAYEKLEKRYKNTRILASHYYNEIFNAPSISKANSFELRKLLSVFSENVAALRIQKPEPILNWNIALARNCQLIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA63</accession>
    <name>A0ABM5LA63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYM-type protein 5-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519329.1">
        <property type="nucleotide sequence ID" value="XM_050663372.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663372.1">
        <property type="protein sequence ID" value="XP_050519329.1"/>
        <property type="gene ID" value="LOC126893322"/>
    </dbReference>
    <dbReference type="GeneID" id="126893322"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26886" checksum="D687706C059109D5" modified="2025-10-08" version="1">MKRTYESGSQKRKEKKRKDDEAARSSKNLNAWLTASTSQTKDQDLCETVNQPTQSESELKKPCQVEDEIKITGRELETCHNESHEELHSTENSTKLINEQGQIEVRVTHELEDALNVSLCDVLPKTVNESELKRKLVRDGPYQPEGPFPRDRQGRCFSSHYYSFTTNAGIKLKRNWLCYSKSNDCVYCLPCWLFPQDVLVTGINLSNLFSKNGVRDWKHISERIASHEGPKVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAZ6</accession>
    <name>A0ABM5LAZ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519612.1">
        <property type="nucleotide sequence ID" value="XM_050663655.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663655.1">
        <property type="protein sequence ID" value="XP_050519612.1"/>
        <property type="gene ID" value="LOC114327349"/>
    </dbReference>
    <dbReference type="GeneID" id="114327349"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="281"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="902"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1196" mass="141329" checksum="FC94B67609635CB5" modified="2025-10-08" version="1">MDFASVRVLLNILPQQIFKKNISETNTKSSDIDLLCKYIKSINNDIDLMKVDDLLEKLRREESIRENSKVRNVIFKSLKVIFINTNSAERLFGFDQLVCCSYDSITQSLLEHNQLELLMTLSEFKDVIRSYIPMAKLEVVLDQISSKKSALNQELVQELIEYLQIPQILREDVYEILQKRMKHKNYKLLAYYLDDINIKDGNLSEYLKLRVSIEEEKRINNIKFFIKLLPSKLLYFQEILTTEGFKKEVLFYKTFVPVIEKLGMSNMDFLPRCYLVKNDMIILNDLSVQGYSSTEEIFFDYEHLSLVIRQLAKLHSMSFLIEHRLSKVLGENIKIDEYFPDLTEEYHILPNELNDTHIEYAVADLEAYSHLAKHISIGEFQKRAKIKFNEIYSAVKKSNSFRNVISHGDIWKPNIFFRWDSNKHPQHSVILDYQLLKYCPQAIDILMVTYVNATKQTRDQYMGILLEEYHSELESTLGQFGMDIEQISPFKDLKQSVEELEVFGIFIAMLYNKFMGLPRDKLGNTLKYPAKNKQFWTDVNYRIEVLNSMWDDVHEEWKKKCEENIIELYELCMSIIIIFFPTICKVFTLYLYVIITYFEDIIIPTLFFHYLITDNLNICYLLVTISLTKIIMGDCVKVLLKVLPQQLCSSEKNCACRKNINLKCFDELFKNVHNKVDVVKIKDLQKKAEAEIRGEVQCLVFKALKVILLNINEEKRLLHYHDLIKLFYNGLIQKLLELHKLDSLLTFQEYEHLVRKLIPLVKLEILLEQYPTINNIRLEELVEYLDMPNILREDIYEVLQKKFGHSNFKLRRYYLAAVSNKGLLTDCASLNVSIVEENEEKTCKFFIKFLPTQETTVQKFMSALAFKKEVLFYEKFVPLLKELGETKLEFIPESYLIRDDLIVLSDITELGYSHSGQDFLDYDHLSLIIKYFARIHSFSIIFEEYFSKKLWEGVLLDTYIPDLLEESQVLPNFFNNSHIEHLLLFLEKFPSVAKDFPLEDFVVRARKKYYDVYNVVKKSKKYKNVLNHGDVWQPNFFYKFDSKHKPSSAIVFDFQLLRYAPPALDLLMLLHVNATKQTRDNYMFQLLLDYHNELKSTLIRFNIDVENIISFNDLQASVQELRIYGNYIGSLYGYFMALPKEKFGPAFANPETNTIFWTDPKFRTDLCYSFWEDISEVWKNEWLNNIEELYELCKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LB70</accession>
    <name>A0ABM5LB70_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519687.1">
        <property type="nucleotide sequence ID" value="XM_050663730.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663730.1">
        <property type="protein sequence ID" value="XP_050519687.1"/>
        <property type="gene ID" value="LOC126893470"/>
    </dbReference>
    <dbReference type="GeneID" id="126893470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="380" mass="43652" checksum="B851DBD868A4EFC1" modified="2025-10-08" version="1">MDEGNTVSNMEEINELRAQIAELKKSLHQTPRVQNPACILQKDTSYDVWRKLVENDFRTFGYLYLIDRNEMKPTLTAEEEKTRSGFAMGYLISRLDDEYKRLVCDLNEPIQVLEKLDTVRRPKIPSTKFLLKRSWSNITYLKGKESATEFITRFEEATRNLMRVAEDDLKEDSIVENFLMAIYNSVPEVVRRYDAAGGKISLNELKSLMINAEASETEAKARCSESESTMALNSVVENDPKGEKQTRSEVVQKVCYRCGKPNHMSFECKSKAIICYNCKELTTNHNGRTCKKRKVLGKNRVGYEYKVTQRGRRFYKNVGKRGRGGVQLQGNRNIKKFKKIKLAGGDDEKPKYAYIAMDESEMVEDEGEANAVEVEGELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZ29</accession>
    <name>A0A6P7EZ29_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114324851</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028128534.1">
        <property type="nucleotide sequence ID" value="XM_028272733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZ29"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272733.2">
        <property type="protein sequence ID" value="XP_028128534.1"/>
        <property type="gene ID" value="LOC114324851"/>
    </dbReference>
    <dbReference type="GeneID" id="114324851"/>
    <dbReference type="KEGG" id="dvv:114324851"/>
    <dbReference type="InParanoid" id="A0A6P7EZ29"/>
    <dbReference type="OrthoDB" id="8195591at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="359"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028128534.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57563" checksum="E48785C8327DE00D" modified="2020-12-02" version="1">MYSDVRSFYKNKNILLTGGTGFLGKLIIEKLLRTCDVEGIYLIVKPKKGLSPEERLRNLLEEPVLAKVRHANARNFHKIHVLDGNLTKKQLGLSEENRTLIKNKINIVFHCGATLNMDLKLQEAVITNVRGTMELLELIKESEQIQAFVQVSTAFSNCYEKTIEEKFYETPIKPELLIQMSEEMNPEMFNSISGKLVGKWPNTYVYTKAITENIVLSKGKYLPVGVFRPAIVTSTVWEPFPGWSDNLYGPLGILLSSHCGLLRVIRANGNLRNHTVPGDMCINAILCFAWDVSRKWDISKENVPPVLNFSAKNTKLFLASGQYTNCSGLDYLPFKKAMWHQFLILAENRYYYLMLKFILHTIPAYIIDTILVLSARKARMKSVYAKIEKTSDILSYFLLHEWDIHNDNVSILWSKMSQEEKEIFNFNVNSVDFNNYMKNMMLGLKKYILKEDMAKAKLHRQRYQRLTLLHYTLKYTLFGLATIPIYKTLARLCLRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3G1</accession>
    <name>A0A6P7F3G1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Apoptotic chromatin condensation inducer in the nucleus-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114325955</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129911.1">
        <property type="nucleotide sequence ID" value="XM_028274110.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503231.1">
        <property type="nucleotide sequence ID" value="XM_050647274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647274.1">
        <property type="protein sequence ID" value="XP_050503231.1"/>
        <property type="gene ID" value="LOC114325955"/>
    </dbReference>
    <dbReference type="GeneID" id="114325955"/>
    <dbReference type="KEGG" id="dvv:114325955"/>
    <dbReference type="InParanoid" id="A0A6P7F3G1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="442"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="519"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028129911.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="79536" checksum="142EF74035A401E8" modified="2020-12-02" version="1">MRRKARNAWKKKTEVNNQVEVTTHEVTNKNEHDKVEKNNEDDKIAGNIDNSNVADPISYTEVSGEDKNENNDREDEEQDQESTQGKSTGLNPDQTSNNIDNQSEIENDNVQGSTPSPKANDESVQNENVTNEDDAVATNEADTASESAPAIENEQTEHDQQEEAFESSYVSHHQENSDSSNHKDTKDNERSHTPELKARSESVYDKKRIVLKRSPIHRSPSPLEDGEIKEPQDKPKKITLKRSSNSNSDFINKIIINRRPSGGTDKSKKSGHNTEGRTHIVIARPIQPSKPIKLNRNALLSGEEDLPVPPTSPHPHRSWGKSDWLENLSATSYKIDVDTIKIVCPSVQFLDESEVKLEDVCKEAIRAEVDVKKRIVKKEEEKSDEESEKEKSEEEDSAEEQKKSEITTNPNIIAVNRKISIVDDTAAKLRPPPSPAKNPPSNILYITNLVRPFTAKQLRELLERTGKIKEGSFWTDRIKSKCYVQYESLEEAETTRNALHGVHWPIGNGKQLSIDYGTEEEMEKAKNPIPTPIVLPVKSPEKENREPELDIRRRDRERDRDQEKEERRKDHSEREWIKKEEPRRQRSRSRSRERVRKHSRRSYTPEIDNRKKHKKPEEPVPQKLMDDLFLKTKTTPSIYWQPLSPQEIATKQQQRLVRMEEHKRRIEENRGRFRDRERDRRGTFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F470</accession>
    <name>A0A6P7F470_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326144</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028130191.1">
        <property type="nucleotide sequence ID" value="XM_028274390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F470"/>
    <dbReference type="FunCoup" id="A0A6P7F470">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274390.2">
        <property type="protein sequence ID" value="XP_028130191.1"/>
        <property type="gene ID" value="LOC114326144"/>
    </dbReference>
    <dbReference type="GeneID" id="114326144"/>
    <dbReference type="KEGG" id="dvv:114326144"/>
    <dbReference type="InParanoid" id="A0A6P7F470"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="444"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130191.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="75546" checksum="0D816547A9367CDB" modified="2020-12-02" version="1">MSCSDEFASIIIPSGSIDASKQIIINVPSNIRGSHVVVPPENNGVDCHLARDFDDEKKENMLNLLNDFKCKRDTLLLSNIRQRLRLLDQMEYVETTVLKKDIRDYQQARKKLVFDLQTIASTLPDLRKCRYELEPRERFYSDKIRIRKMGDQGDNLYLGLDLSTQQLKAAVVNEKLEIVAEQIVIYDSDLPEFRTQGGAIIDKINNAYITSPTLMWVKALDIVLDKLTVAGINFSKIAAISGSGQQHGSVYWQRGASQTLANLNPGEFLHQQLAHSFAVANSPIWMDSSTTKQCQLLEQAVGGPMKLAEITGSRAYERFTGSQICKINQTRPDAYKSSERISLVSSFVCSLFAGKIAPIDISDGSGMNLMNIKTKKWDETLLAVCGSNLAEKLGDPVPSTTIVGNVSPYYVDRYNFNPNCKTIACTGDNPASLIGMRLSENWIAVSLGTSDTVFLWLQEPKIVLDGHVLCNPIDENAYMGMLCFKNGSFTRERIRDQCAEGSWDVFNELLESTPRGNFGNIGLYYDNQEIIPFLHGDYRFSKGGRVTKFNSLEVEVRAVIEGQCIRNRAYSEDFGLKIDKNTKILATGGASNNKAILQVLSDVFNVPVYVQQAANSAMLGAAYQAKHGLFFGQKSYRDVMSPLPEPELACTPYQDAESIYIPMVHRYRAIVKELTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5I6</accession>
    <name>A0A6P7F5I6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114326750</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the prophenoloxidase (proPO) cascade immune response. Binds to 1,3-beta-D-glucan and PGN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130984.1">
        <property type="nucleotide sequence ID" value="XM_028275183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5I6"/>
    <dbReference type="FunCoup" id="A0A6P7F5I6">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275183.2">
        <property type="protein sequence ID" value="XP_028130984.1"/>
        <property type="gene ID" value="LOC114326750"/>
    </dbReference>
    <dbReference type="GeneID" id="114326750"/>
    <dbReference type="KEGG" id="dvv:114326750"/>
    <dbReference type="InParanoid" id="A0A6P7F5I6"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF75">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN SB1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0391">Immunity</keyword>
    <keyword evidence="2 7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028380489" description="Peptidoglycan-recognition protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="11">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="61"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028130984.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21034" checksum="66A54048F4340BEB" modified="2020-12-02" version="1">MVIKVGVLVFVVLIGVDQIAASCPTIISRSQWGASAAKSKTNLSRNPPPYVVIHHSETPPCPVTEKCKQRVKNIQYDHINNRGWSDIGYNFLIGGDGNVYEGRGWGLQGSHCPNYNSRSIGICLIGDFQNHLPSAGQLEALKNLIDCGVQNNKISSSYKLIGHRQGRQTKCPGDALYEEVTKMPHWEAHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7J2</accession>
    <name>A0A6P7F7J2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endocuticle structural glycoprotein SgAbd-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114325727</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129658.1">
        <property type="nucleotide sequence ID" value="XM_028273857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7J2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273857.1">
        <property type="protein sequence ID" value="XP_028129658.1"/>
        <property type="gene ID" value="LOC114325727"/>
    </dbReference>
    <dbReference type="GeneID" id="114325727"/>
    <dbReference type="KEGG" id="dvv:114325727"/>
    <dbReference type="InParanoid" id="A0A6P7F7J2"/>
    <dbReference type="OrthoDB" id="6372059at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027922322" evidence="4">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028129658.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16883" checksum="5B87C8CCC45D1EFB" modified="2020-12-02" version="1">MNHLLIAFSVFIVASLAQQHQEPIPIVSYENEGVNADGSYRWSFETGNGISAQEQGQIKNIANEEAGPEVQGQVQYTGDDGVPVSLTYIANENGFQPQGSHLPTPPPIPEAILKALEYNAAHPEEDDEAQNRVQRRQAAAAAQQVPKNANRFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAG3</accession>
    <name>A0A6P7FAG3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-1,4-glucuronyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114328246</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132839.1">
        <property type="nucleotide sequence ID" value="XM_028277038.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515562.1">
        <property type="nucleotide sequence ID" value="XM_050659605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAG3"/>
    <dbReference type="FunCoup" id="A0A6P7FAG3">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277038.2">
        <property type="protein sequence ID" value="XP_028132839.1"/>
        <property type="gene ID" value="LOC114328246"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659605.1">
        <property type="protein sequence ID" value="XP_050515562.1"/>
        <property type="gene ID" value="LOC114328246"/>
    </dbReference>
    <dbReference type="GeneID" id="114328246"/>
    <dbReference type="KEGG" id="dvv:114328246"/>
    <dbReference type="InParanoid" id="A0A6P7FAG3"/>
    <dbReference type="OrthoDB" id="9974378at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47412">
        <property type="entry name" value="FI01434P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47412:SF1">
        <property type="entry name" value="FI01434P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028132839.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53312" checksum="7A7A36C210B753CC" modified="2020-12-02" version="1">MYTNRKSFIIKLLVGCCALYLFIHVFTNTAVPVIREMQESGRNLAALGTDNLEVPAVLDEDSAKEVVAAKDLLESEQVPDKTEPEEVSPSSKAIPTILDRVREVTNCVDKPLVPKIQQRGDYWVLYNYIPAEVSHRCHESITYTTHADYSFMDNLVPLLERWNGPISIALHAPGTDFENTLESIGYLRDCTTPMVKQLVTFHIYFSTKHVPKEVPKHDNVFIETYNCSVVPPFLNVSSENMYKAQKKLLYPVNVGRNVARETAQTHFILPSDIELYPSPSVIEKFLAMIAENSGPLQNKHSKVYPLTIFEVSANQQVPENKTQLREMLANGTAIPFHKKLCPGCHTVPKAKEWQSANETQGLHVFHVGKRNGKFVHWEPIFIGTHADPLYDERLSWEGKMDKMTQGYALCVLDYDFMILDNAFLVHKPGIKIYKKDPRRAMLAGKTHQLINKIIFPELKVLYGVRKGCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBQ7</accession>
    <name>A0A6P7FBQ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114328399</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028133041.1">
        <property type="nucleotide sequence ID" value="XM_028277240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBQ7"/>
    <dbReference type="FunCoup" id="A0A6P7FBQ7">
        <property type="interactions" value="2253"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652244.1">
        <property type="protein sequence ID" value="XP_050508201.1"/>
        <property type="gene ID" value="LOC126885618"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FBQ7"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028133041.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33446" checksum="B3906709D96F18CB" modified="2020-12-02" version="1">MPAATLGSIPHPNNEDCGIRDVWAHNLEDEFRTIRQIVQKYQYVAMDTEFPGVVARPIGEFRSSADYQYQMLRCNVDLLRIIQLGLTFLDDNGKTPGGAYTTWQFNFKFNLQEDMYAQDSIDLLQNSGIQFKKHEDEGIEPLEFAELLMSSGIVLVENIKWLSFHSGYDFGYLIKLLTDNNLPQDETEFFDLLKLYFPTIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMAFFKMKEMFFEDTIDDSKFSGHLYGLGTSFAVNGTANNYSNDNGDTTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDA5</accession>
    <name>A0A6P7FDA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114328885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114328885</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133661.1">
        <property type="nucleotide sequence ID" value="XM_028277860.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502300.1">
        <property type="nucleotide sequence ID" value="XM_050646343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277860.2">
        <property type="protein sequence ID" value="XP_028133661.1"/>
        <property type="gene ID" value="LOC114328885"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646343.1">
        <property type="protein sequence ID" value="XP_050502300.1"/>
        <property type="gene ID" value="LOC114328885"/>
    </dbReference>
    <dbReference type="GeneID" id="114328885"/>
    <dbReference type="KEGG" id="dvv:114328885"/>
    <dbReference type="InParanoid" id="A0A6P7FDA5"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028133661.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21522" checksum="0528AF78D7C908E9" modified="2020-12-02" version="1">MGQSYSTYNTKRPNDSTKDPNCNITDNRIKNSESSKQTSSKKQHQISNAADACRPRNCPRTNEPLIRCTPKEPPCPETPTQVAQQAPQDCSQAEKEVPTKPTRVECPLRECPPKSSASLQPAKAEQYCPGSPKPAPIRPQGGPCGVPKAARRGLSTWAKLGLAAIALFSGFAMYNIYFRDDCEDTCTCGCKPKDDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEG1</accession>
    <name>A0A6P7FEG1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box only protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114329274</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028134121.1">
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        <property type="gene ID" value="LOC114329274"/>
    </dbReference>
    <dbReference type="GeneID" id="114329274"/>
    <dbReference type="KEGG" id="dvv:114329274"/>
    <dbReference type="InParanoid" id="A0A6P7FEG1"/>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028134121.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39012" checksum="DB8E070829C779ED" modified="2020-12-02" version="1">MPFISKDWRSPGEAWVKTEEGWEKKKVLENCKALQKVSRNDSSEEESDSDTAIQPHCHITIKCTKEIAGFNELDEAVKRLDFRSAVRDVRRFNYICALLELLIGQQMTALSGCSQKVLLAMLEEVASHATTSQHNPRGLRQLLTNLRALRTAERDACWGGTLGSQVLWHQHATKIERILNMAAEMQIREPNPNSMPKLMQLPEECIREIILRLSDHKDLVASAESCEQMAAIVSEQRIWRELTKFHFVPQQIDLVLSKDNSKIDWKEVYHSLKKTFGINEERQYAEMLSLCRYCRCLFWRSLGHPCIADQCPEFRARIQEAGGVSAPAPVPPSAFLKFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFQ4</accession>
    <name>A0A6P7FFQ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC114329665</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12 13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028134646.1">
        <property type="nucleotide sequence ID" value="XM_028278845.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028134647.1">
        <property type="nucleotide sequence ID" value="XM_028278846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503302.1">
        <property type="nucleotide sequence ID" value="XM_050647345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFQ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278845.2">
        <property type="protein sequence ID" value="XP_028134646.1"/>
        <property type="gene ID" value="LOC114329665"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647345.1">
        <property type="protein sequence ID" value="XP_050503302.1"/>
        <property type="gene ID" value="LOC114329665"/>
    </dbReference>
    <dbReference type="GeneID" id="114329665"/>
    <dbReference type="KEGG" id="dvv:114329665"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
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        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
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        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
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        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
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    </feature>
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        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028134646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028134647.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40221" checksum="FFC0C4AACD698158" modified="2020-12-02" version="1">MSDLFSVSEFEKHALEVLPKNIRDYYRSGAGRQETLADNRKAFFRYKVRPRYLRNVENIDLSTVVLGEKISMPIGIAPSGMQKMAHPMGELAVVKAAQEMGVVYTLSTMSTYSIEEVAQAAPMAVKWFQVYIYKDRDLTRNLILRAEKAGFKAIVLTVDAPLFGLRIPDLKNKFTLPPHLKLANFEGRVSEMSQDPTKGSGLNNYVNDLFDPSINWEDIKWLKSITNLPIVLKGILTAEDALLAVEAGVAAVQVSNHGSRQLDGTPAAIDALCDVVKAVGDKIEVYIDGGVTDGVDVLKAVALGAKMALVGRSALWGLVHSGQQGVERVLNILKNELRTGLGISGYSKINQIDRSLVVHESYYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG44</accession>
    <name>A0A6P7FG44_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329068</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133882.1">
        <property type="nucleotide sequence ID" value="XM_028278081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG44"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278081.2">
        <property type="protein sequence ID" value="XP_028133882.1"/>
        <property type="gene ID" value="LOC114329068"/>
    </dbReference>
    <dbReference type="GeneID" id="114329068"/>
    <dbReference type="KEGG" id="dvv:114329068"/>
    <dbReference type="InParanoid" id="A0A6P7FG44"/>
    <dbReference type="OrthoDB" id="8196563at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000280">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="66"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133882.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="38150" checksum="200E8C7E9C930DAE" modified="2020-12-02" version="1">MLLQGYNDPPGRQMQRPAGILDSPTLARVERAMLRHEEGTNREGQDVLRAQYTQSLLPSFGKESAHVIKRGLMWQQRDRLFSRWKERYFILTRDYLHVFRRASGSDRISEMGQFLFKVKLIDIVKIEWENKKSYSTVALVLGRDGKIYLRSSEGLEDWFELLEECMFTSKERRKALRYSHNDNNKPRDNNNIPNLDEWIASRQKIDLGRLVTASMNSRQETTVRRRYRPQTEDDDWIPPSLDNRLSLLTDIDISTYDDSTIGTPSVTSYRLSDDVFCVQPPSLRAMGSFRSSRETGAISKRNDNGNIPDTKYFKFRERSYSDIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMA8</accession>
    <name>A0A6P7FMA8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114331895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114331895</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137384.1">
        <property type="nucleotide sequence ID" value="XM_028281583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FMA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281583.2">
        <property type="protein sequence ID" value="XP_028137384.1"/>
        <property type="gene ID" value="LOC114331895"/>
    </dbReference>
    <dbReference type="GeneID" id="114331895"/>
    <dbReference type="KEGG" id="dvv:114331895"/>
    <dbReference type="InParanoid" id="A0A6P7FMA8"/>
    <dbReference type="OrthoDB" id="10569678at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027655594" evidence="2">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028137384.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="24160" checksum="AF3A5F03F2DCA560" modified="2020-12-02" version="1">MIMYKEILLIVVIFANLHHGESFVPFLGLIRDGISTVYNGVDCGLYKLESWIRNEPTPCNFEFFGSSKQNKNNRVHHEDVPPKQKYAREKGYYEESDSEEETDRKGKFYHLEDEQKVQPQEKYHGKALRVGEKKYIVLKEKKMDDSNSPADYDDESEEQELVETLNKVIEQEDNKKEEKFKIEKYKIDFLTPSPKEKIKKKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRV2</accession>
    <name>A0A6P7FRV2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114330450</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135595.1">
        <property type="nucleotide sequence ID" value="XM_028279794.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FRV2">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279794.2">
        <property type="protein sequence ID" value="XP_028135595.1"/>
        <property type="gene ID" value="LOC114330450"/>
    </dbReference>
    <dbReference type="GeneID" id="114330450"/>
    <dbReference type="KEGG" id="dvv:114330450"/>
    <dbReference type="CTD" id="37272"/>
    <dbReference type="InParanoid" id="A0A6P7FRV2"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000198">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000448">
        <property type="entry name" value="Toll-like receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF35">
        <property type="entry name" value="LEUCINE RICH REPEATS AND TRANSMEMBRANE DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027684797" evidence="12">
        <location>
            <begin position="17"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028135595.1"/>
        </source>
    </evidence>
    <sequence length="1309" mass="149004" checksum="25E438E11433B1A1" modified="2020-12-02" version="1">MYQLLKVLLLVVYGVATRFDGPEQCSWLPDNTDTSSSKLSVTCKVRVLEESANVTALPTEVTSRLKIICSDVLFFESFLPTSGLHRLHELEELRINNCKVLTIPPNSFDGLYNVKKLSINTFNADWGPTKILELTTYSLEGLKELQVIDLADNNIRALPDGVFCSLTNLQTLNLTRNRIKNPERIGLNVPDCSNSELQNLDLSFNDLKILNEEAGFSRLRRLQHLFLQNNNITELSGETLAGLVSLKILNLNNNKIGTLPEGLFAGTPELKEIHIQNNSLYSLAKGIFHRLEQLLVLNLSGNQLTSNHIDAGTFTGLIRLIILNLSHNALTRIDGRTFKDLYFLQILDLRNNSIGFIEDNAFLPLYNLHTLNLAENRLNTIGVQLFNGLFVLSKLTLNNNLIVSIHSSAFLNCSALKELDLSSNALSEVPDAIQELSFLKTLDLGENQISDFRNGSFKNLNQLTGLRLIDNNVGNLTKGMFWDLPNLQVLNLAKNKIQNIERGTFERNTQIEAIRLDENFLTDINGVFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNFIEHLANYYKIQDEIRVKTLDASHNRITEISPMSIPNSIELLFINNNFIKSVQPNTFLDKSNLARVDMYANDMTNLDLNSLRIAPVHSNRSLPEIYLGGNTFHCDCTMEWLQLINNMSASRQYPRVMDMDNIVCKMTHSRGMTHMPLNQAKQSDFLCNYETHCFALCHCCDFDACDCEMTCPNNCTCYHDQTWNNNVVDCSGQNADEVPQKIPMDVTELYLDGNYIKELQNHVFIGRKNMRVLYVNNSAVETIQNSTFNGLQSLQILHLEENKIGELKGYEFEQLSNLKELYLHNNLISVIGNNTLEPLISLETLRLDGNRLVTFPVWQLSVNTRLSIIMLGNNQWSCRCKFLQGLTAWVADNAAKIVDSADMMCYNPDSKPPQRRELDFNSTACSDFYAGSSVIDSMLVSDYWPMVVVSLCIVILLLLVLVLWFVFRDPVRVWLYSRYGVRLCSFRDTAAKQFEDRDKLYDGFVCYSPKDEEWVVQALAAELEPKFQLCLHYRDLPHTAYIQHAAPAVLEAAEASRRVIVVLTRNFLQTEWSRFELRQALHEALKRRVFKLVILEEGPLPEAELDPELRLYLKTAERVRWGEKRFWEKLRYAMPSVEPRGKINANYRRNINNYTIDSRVVANGTHHTHHTYPEKIRTQGPPSPGMQMLPPSYSSAVPQEPDDANYSSATTATPSPRPMRRAQEPRPISDHIYSSIDSDYSTLERGGSGRRGPPWRPQHVMMQTGMNNGGQAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FSE9</accession>
    <name>A0A6P7FSE9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RNA-binding protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114333537</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139226.1">
        <property type="nucleotide sequence ID" value="XM_028283425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FSE9"/>
    <dbReference type="FunCoup" id="A0A6P7FSE9">
        <property type="interactions" value="2810"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648646.1">
        <property type="protein sequence ID" value="XP_050504603.1"/>
        <property type="gene ID" value="LOC126883293"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FSE9"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="153"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="792"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028139226.1"/>
        </source>
    </evidence>
    <sequence length="870" mass="98046" checksum="06735DF2AF720EC2" modified="2020-12-02" version="1">MSSSPEPSNRISPNPFSPNYRHKSDSGSKSPVSNRRQNGYLKKSQYDSDSGDSDYAQDHVRENRKARSRSPDQQDRDRDRRERHRTRDRDRDHRRQRSRSSSSRWEKKQKRDRDRDRCRDDDRDSTSERSYGCMPIGASGSEIIGFKSQPPNNTIMIRGLAQHISEYDIRQDIIGCDLFPKDIRLIRKKDTGASRGFAFVEFSTLGEAVRWMEKKQGVLMLQDQYRAIMQYSIPKDSNSAEKTPSYKASADWFCIKCGAQNFKRRDNCFKCHASKTESEEGGSGSDEVCMYATKTIMLRNLDALTTEESVMAVLKQIIPELVETISVVCIGRDPLTSTSRGLCYLETRSTVDSLAIFAGLSNHKTPVTIDGKSVIVSYCKYVKGDTKRPYSQVDQDVFPNAAVPSTYSMADVDSLAEYAARRYAKSPQEYMHYIEYYRVYFAKQITDGNSITLQENQMDAVNAAAAVAQSAIQQLNATKTGTSSYVDSEQPPTGVDGKKYPVPDTARYIYDKNTGYQYCQTTGLYYDPSSKYYWNTSIQKWLYWDHDKQTYSLAQAEDTSNKQSTIESNATQEPESKKQKVDKQDKVKVAKKIAKDMERWAKTLNQKKESSNVKAATEFIGYANMASADIGFSVLEKKALVGPTTSAATSSTPLAPYIKEVDDRSPTLPGPLVAAYGGESDSSGEEEDDFLDYTNLICNLCKRRLNSAEALTKHSKMSSLHLQNLELRNKKSTKFDETVADKAAYRDRAKERRMKFGDPDAPKPSKLKEKYLKAREAEISMPSSSVLEPIGAENVGNRLLQKMGWTEGQGLGKQNQGRTSIIQAEQHSSTAGLGNKLAGYTAVAGESYKDCVKKMMYARYQELTEKELNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FY62</accession>
    <name>A0A6P7FY62_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II-associated factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114332207</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137758.1">
        <property type="nucleotide sequence ID" value="XM_028281957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FY62"/>
    <dbReference type="FunCoup" id="A0A6P7FY62">
        <property type="interactions" value="1956"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281957.2">
        <property type="protein sequence ID" value="XP_028137758.1"/>
        <property type="gene ID" value="LOC114332207"/>
    </dbReference>
    <dbReference type="GeneID" id="114332207"/>
    <dbReference type="KEGG" id="dvv:114332207"/>
    <dbReference type="CTD" id="40593"/>
    <dbReference type="InParanoid" id="A0A6P7FY62"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="546"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028137758.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="67036" checksum="A497A01169FC58EA" modified="2020-12-02" version="1">MAPTIQQNNQNGTANGVEKRPVKTVEKRSDLICKVKYCNTLPDIPFDLKFIAYPFEPIRFIQYNPTSLERNYKYEVLTEHDLGVSIDLINKDIYAIEPGATLDPADEKLLEEDILTPQDSKRSRHHAKSVSWLRRTEYISTEQTRFQPQTMDKVEAKVGYSIKKSLNNETLYMDRDSQIKAIEKTFEDSKNVIEKHYSKPNVVAVDILPVYPDFSLWKYPCAQVIFDSDPAPVGKQVPAQIEEMSQAMIRGVMDESGEQFVAYFLPTEDTLQKRRDDFVNQIPYQDDEEYEYKMAREYNWNVKSKASKGYEENYFFVARPDGIYYNELETRVRLSKRRVKAGAPPSNTRLIVKHRPMDANEFRMQRYREKQLEPPGEDDEEMEVDEPQEEEATQEEQEQEKGEKSPSRSRSRSNSSNRSRSRSKSRSKSRSKSRSKSRSKSRSRSKSKSQSRSRSRSKSRSRSHSRSRSRSKSRSKSRSRSKSKSKSKSRSRSKSQSKSPSRSRSRSRSKSKSRSRSASGSRSPSGSRSRSPSKSKSRSRSRSRSGSKSASRSRSSSKASSKSGSRSRSGSRSGSGSESGSGSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2A3</accession>
    <name>A0A6P7G2A3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114335163</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141147.1">
        <property type="nucleotide sequence ID" value="XM_028285346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2A3"/>
    <dbReference type="FunCoup" id="A0A6P7G2A3">
        <property type="interactions" value="1288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285346.2">
        <property type="protein sequence ID" value="XP_028141147.1"/>
        <property type="gene ID" value="LOC114335163"/>
    </dbReference>
    <dbReference type="GeneID" id="114335163"/>
    <dbReference type="KEGG" id="dvv:114335163"/>
    <dbReference type="CTD" id="6209"/>
    <dbReference type="InParanoid" id="A0A6P7G2A3"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141147.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="17068" checksum="CC13AEDEA176B13C" modified="2020-12-02" version="1">MADKAEELVKKKRTFKKFTFRGVDLDQLLDMPNEQLMELMHCRARRRFTRGLKRKPMALVKKLRKAKKEAPPLEKPEIVKTHLRNMIIVPEMVGSIVGVYNGKAFTQVEIKPEMIGHYLGEFSLTYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3S9</accession>
    <name>A0A6P7G3S9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integumentary mucin C.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114337373</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143591.1">
        <property type="nucleotide sequence ID" value="XM_028287790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3S9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287790.1">
        <property type="protein sequence ID" value="XP_028143591.1"/>
        <property type="gene ID" value="LOC114337373"/>
    </dbReference>
    <dbReference type="GeneID" id="114337373"/>
    <dbReference type="KEGG" id="dvv:114337373"/>
    <dbReference type="InParanoid" id="A0A6P7G3S9"/>
    <dbReference type="OrthoDB" id="10601183at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028343438" evidence="2">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028143591.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="17643" checksum="8AB8356FC5F04B65" modified="2020-12-02" version="1">MNLIKCICAIFCIGIIISESTFIFPNPLDQIFTRPCIWVIIRRRPPFPTLGSNDTLPVHPPVPSAPGTVAQTTIATNQAEANPATTASAAPAAETTTTVVAETTAASTAVTTSASAAETTAAAAAETSAATAESTMAMELSTSTETTTIAASTTIAESSTAAHEAAETTTVPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G590</accession>
    <name>A0A6P7G590_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b-c1 complex subunit 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114333888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139690.1">
        <property type="nucleotide sequence ID" value="XM_028283889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G590"/>
    <dbReference type="FunCoup" id="A0A6P7G590">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283889.2">
        <property type="protein sequence ID" value="XP_028139690.1"/>
        <property type="gene ID" value="LOC114333888"/>
    </dbReference>
    <dbReference type="GeneID" id="114333888"/>
    <dbReference type="KEGG" id="dvv:114333888"/>
    <dbReference type="InParanoid" id="A0A6P7G590"/>
    <dbReference type="OrthoDB" id="15743at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.220:FF:000005">
        <property type="entry name" value="cytochrome b-c1 complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029027">
        <property type="entry name" value="Single_a-helix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015089">
        <property type="entry name" value="UQCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15420:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15420">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 6.4 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08997">
        <property type="entry name" value="UCR_6-4kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81518">
        <property type="entry name" value="Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028139690.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7187" checksum="A3D83739D0140191" modified="2020-12-02" version="1">MSGVRAVTKLATTPGPIGKKHIEIAQQWIGSAAAFGAVAGVTLCYVTDWRVIVDYIPYYNGKFKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6C5</accession>
    <name>A0A6P7G6C5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heterogeneous nuclear ribonucleoprotein 27C isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114338219</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144604.1">
        <property type="nucleotide sequence ID" value="XM_028288803.1"/>
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        <property type="interactions" value="1929"/>
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        <property type="protein sequence ID" value="XP_050506161.1"/>
        <property type="gene ID" value="LOC126884266"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM2_DAZAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 27C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="125"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="373"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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            <dbReference type="EnsemblMetazoa" id="XP_050506161.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_028144604.1"/>
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    </evidence>
    <sequence length="447" mass="47578" checksum="791FE3EF85B28A73" modified="2020-12-02" version="1">MRMLRLKQEIMDDDEKGQPHQSSIAPYIDDSHPGYKLFVGGLSWETTQDNLQRYFSRYGEVIDCVVMKNAESGRSRGFGFVTFSDPANVNVVLQNGPHTLDGRTIDPKPCNPRTLQKPKKGGGYPKVFLGGLPSNVTETDLRSFFTRFGKVMEVVIMYDQEKKKSRGFGFLSFEDEEAVDRCVQEHFVNLNGKQVEIKKAEPRDGSGGNKMGGDPASAWGPPQAPMGMMQGPNGQMGGPPMNIGAPMGPNMMQSYQGWGTSPQQQSYASYGTPSGPGSYQGWGAPPAPQGPPPQWGNNYGGPPQQQGYGSYGPSAGSGTANWNSWNVAQSNGSSGPSGYIAGDMYSRGQSGPAGPGTPSGPPNMSSSGTNSKPGSDYNYAGYGSYSTEAGYGAPPRSYGSDAGSQVGGYSSQPPNPGNHTAAAGDYVNGPQRGNSTYGVQAYHPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8F5</accession>
    <name>A0A6P7G8F5_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114339005</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="XP_050512625.1"/>
        <property type="gene ID" value="LOC126888417"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028145431.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="48171" checksum="D4A8767318CCD9FC" modified="2020-12-02" version="1">MDYLPTEIIERILRYCDGKTLLNARKTDEKFKAVVDYLTQKTEIWKCCCNEDIPKNQLIEYLQRYNEESYDKWLNIYINWSSWENPKQVVCDIILSPVEVPKISCMAVSRHFIAVGSQDGRLRIFTNQWKIVFSARLLAVRINSLTFIESEHDAKGIDMCLALSFNNGLNIFCFDGLYSNHLEVHDVKSHSVYKNFICYEKIGGRITIAKLKSIEGGRRELSEIWFSRIYSPSSLSCMKMWDGVCTFLINNEVKIIEYGTIEGSTMDLMKKKTKISFNFPLSDTSVTQILRNDVIISLSKCEDFLNCNLIEFFLLGENDKCSKKAFSIWEIFKCFITCIYVYGNTLILGTDVGSIYIYSVSSWKNLDLRNYSHKLLIGKHPITCMDVKEMQNERRIYVATRINIHEVSGFLPNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8T3</accession>
    <name>A0A6P7G8T3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114334968</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140905.1">
        <property type="nucleotide sequence ID" value="XM_028285104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8T3"/>
    <dbReference type="FunCoup" id="A0A6P7G8T3">
        <property type="interactions" value="1791"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285104.2">
        <property type="protein sequence ID" value="XP_028140905.1"/>
        <property type="gene ID" value="LOC114334968"/>
    </dbReference>
    <dbReference type="GeneID" id="114334968"/>
    <dbReference type="KEGG" id="dvv:114334968"/>
    <dbReference type="InParanoid" id="A0A6P7G8T3"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028140905.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43016" checksum="1DD22244D54CD208" modified="2020-12-02" version="1">MKLISQDVDKNGEGTVALIPEEPEDMWHAYNLISEGDSVKSTTIRKVQSESSTGSSTSSRVRTTLTISVENIDFDTQACMLRLKGRNIEENQYVKMGAYHTLDLELNRKFSLRKPEWDSVSLERIDMACDPTKSADVAAVIMQEGLAHVCLITSSMTLVRAKIDVNIPRKRKGFVQQHEKGLAKFYDTVMQAILRHINFDIVKCILVASPGFVKDQFYEYMFQTAVKTDNKILLENKSKFMLIHSSSGFKHSLQEILQDPSVINKISDTKAAGEVKILENFYTMLQCEPAKAFYGKKHVEKANSEQAIETLLISDNLFRCQDVKLRKEYVNLVDSVRESGGDVKIFSSLHISGEQLEQLTGVAAILRFPMPELEEDSDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCC0</accession>
    <name>A0A6P7GCC0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 135-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114340424</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146959.1">
        <property type="nucleotide sequence ID" value="XM_028291158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCC0"/>
    <dbReference type="FunCoup" id="A0A6P7GCC0">
        <property type="interactions" value="1073"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657369.1">
        <property type="protein sequence ID" value="XP_050513326.1"/>
        <property type="gene ID" value="LOC126889260"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GCC0"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028146959.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54556" checksum="DF38A7616897E4BA" modified="2020-12-02" version="1">MSQTFSKIIPITSPIAATCMEYVHPWTDSCAQATCGLYLYCIYDSLRIYGTVYMLTLLMKGRIPTKDDLKKTFFGIIQSTAFLSGTGFGYSLFLCLLRKTFGNYNILTVSAIPVFLSSVFSILIERPSRRILLALYVSNVATETLWNMAKSRNMISSIRYGDVAIYSISMAILSMYFKGGYHKSSDCPDSHDDAMFRVMRFVIGPYEEKGYMRSPSQSNTFYREVHKDDEPSTSSGAGSSRSWQTTRRKNGVYRIVCQMLRVYSRIINKLKSCSRHPSCQHPFSCLYYTIEGAGRMFSLGLGLQVTLKLVLNLKRVLQSPQNIKSILFRKETFNLAMFLGLYNGVFRACLCILRRVRGGDSPVHALPAGILAGMAFSRYPDSTVSLYVLWKVAQITYNLGIDKGILPKVPGFTEFLYCFSTAVLFHAAILEPTNLRPSYWKFLHSISGGRIACMARAPLDVWGLNSSDSLNTVLRVTKTVPIVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GE98</accession>
    <name>A0A6P7GE98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-binding protein 5-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114337090</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143268.1">
        <property type="nucleotide sequence ID" value="XM_028287467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GE98"/>
    <dbReference type="FunCoup" id="A0A6P7GE98">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653342.1">
        <property type="protein sequence ID" value="XP_050509299.1"/>
        <property type="gene ID" value="LOC126886408"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GE98"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF8">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028143268.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61439" checksum="87B55D45675975C2" modified="2020-12-02" version="1">MCENGSEYNDTVDPRVHVELERLNNATDEINKLEVELDECRTAFKQLLCESTLKVDAIRVKLGMCVERARPYYEARFYANEMFKHSQVAACKFEKANSAHSAAREMVYLAEQGLGGRTLDPAWQEMLNHATQRVNDAERDRGLAETEHRIACVKHDAANAKVQSLQKELKRAITKSSLSIRRSLMQMSNILSQHELMFLPYYEMKAHYNQLLEHQKARVHTLESQVANAKLTYADALKSLEQISDEIHQNRKRVSLLAANFASGKQRSLDSNISLLDDAQELIEEFKSLPQKLGELSSPISSKLEEVEGYRNPLFSASPTSPLSTSERLEQPSIAQSHSSEWTEINLDSSSPEDNSPNKKLERDFGKPLLTRQKTLPNPKSDNEYSAIKSKMKLDHSISNWISRSSAKNEDNIPMNGSRRQSLDNILGPTGEKVKEIFSQGMMMLNISALTERRNSEPKLGLTEERMRNGTTKKIPSPLEKTLTYLTVEDDNSDTDSVSSIDMLNEDQISSLMLDPNIVCEQVLGTPMAEVVYLPQFLSSQPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFF2</accession>
    <name>A0A6P7GFF2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Bleomycin hydrolase</fullName>
            <ecNumber evidence="3 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114341740</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_028148356.1">
        <property type="nucleotide sequence ID" value="XM_028292555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFF2"/>
    <dbReference type="FunCoup" id="A0A6P7GFF2">
        <property type="interactions" value="1754"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647155.1">
        <property type="protein sequence ID" value="XP_050503112.1"/>
        <property type="gene ID" value="LOC126882292"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GFF2"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028148356.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="52615" checksum="499DB947B1974B61" modified="2020-12-02" version="1">MDSSKEVQGFLDEEILGNFRKEFYADQKNLLAQNVCSKIDPFEAALRRKTLEETHHVFNHKIEAEGKPVTNQRSSGRCWLFAALNVIRLPFIKHHNIEDFEFSQAYLFFWDKIERCNNFLLNIVETARRNEAVDGRLVSFLLHDPTSDGGQWDMLVNLINKHGLMPKKNFPESFSCEQSVKMNQILKSKLREYARAIRELISKGGSDADIHTLIQSQMVNIYRVVGICLGIPSETFTWTYYDKNKAFQSIGPITPKEFYEKHVKPHFNVDDKVCLVTDPRPTNEYGKVYTVDCLGNMAGGRKCIYNNQPVELLLDLTAKSIKEGEAVWFGCEVSKRYVAKQGIQDLKAHDFPLVFGVDIQVDLSKADRLLYNESAMTHAMVFTAVSTNEAGEVTKLRVENSWGEDRGEKGYLIMTSDWFKEFTFEVVVDKKFVPEQVLDVFKQEPIVLPAWDPMGTLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GG85</accession>
    <name>A0A6P7GG85_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Facilitated trehalose transporter Tret1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114342155</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028148739.1">
        <property type="nucleotide sequence ID" value="XM_028292938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GG85"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292938.2">
        <property type="protein sequence ID" value="XP_028148739.1"/>
        <property type="gene ID" value="LOC114342155"/>
    </dbReference>
    <dbReference type="GeneID" id="114342155"/>
    <dbReference type="KEGG" id="dvv:114342155"/>
    <dbReference type="InParanoid" id="A0A6P7GG85"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028148739.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="50740" checksum="3D10EF8ACEA5C824" modified="2020-12-02" version="1">MVSQKSNYFLYWAVISVNFLSINMATLFSWTSPTIPKLYSNDTSINPLGKPITPAEESLIASLPNIGAILGTIVSGLLADKLGRKRTLILCALPFFACYILIANASKFYLFVVARIILGVSVGIALTVLPSYVAEISEDSNRGILSSIFGIMNAVGHLCSFVVGPLVSVQGYAYFLLIPVTIFFVTFVPFVPESPYYFMAKDDTNKAEKVLKKIHKNSDTSKELQHIQDVVYRSKHQKVNWKELTVAPTRNAMIACCGLLLFQQCMGIPFILLYLQPILNASGNIIPSSLASIIIGFVQIVLCSVATLLIDRLGRKILLQVSSTGSIVSLVGLGVYFYLQSHNYNVDPIFWLPLASLINFYVFFNIGYATIPWTIGGELFATNVKSICVSIGSFGALTLGLVIVAAFPFIRETFGMSGVFFLFSGIASFSIIFVSIFVPETKGRNFLEIQNALSRRQKPIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIZ3</accession>
    <name>A0A6P7GIZ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pumilio homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114338763</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145178.1">
        <property type="nucleotide sequence ID" value="XM_028289377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500118.1">
        <property type="nucleotide sequence ID" value="XM_050644161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIZ3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644161.1">
        <property type="protein sequence ID" value="XP_050500118.1"/>
        <property type="gene ID" value="LOC114338763"/>
    </dbReference>
    <dbReference type="GeneID" id="114338763"/>
    <dbReference type="KEGG" id="dvv:114338763"/>
    <dbReference type="InParanoid" id="A0A6P7GIZ3"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="414"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="506"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="650"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="689"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028145178.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="84633" checksum="5177A335FD2B4290" modified="2020-12-02" version="1">MVVLQETGSPIHAPAAILDHLDYRRLKMVPKRYLSIHPYLTPFCAKDLKTQIQLFRSQQSQAATPSAAQLQLLQQQQQQYLAQQQQAAAAFPQPPYLVNPQQEPYLITAGVPAQYYGVGPWVYPAPPANLIQQGASNGARRPLTPNGTTEAQQQVQPQVPGGYIVPYYDQNATPILMAQNAAAMRNGTPMRLVSPAPVLVQPQAAAAAATRQTQAAAAAHAAAASLYSSTQQSLYGATNVNTSVNGTTLGGVAQGVGSGLFQTLHAPPSGPFGSSSLGNIGSSATTTSLHTDNLTGLGLTTTTTARRDSFDRNTSAFSPSLEYRQKWPTSYNIGSSPSPLTGSLTPPPTAPLQLGGLVNSRVLSAAPGAEAKYRNSVAAGLNTTAIFGSTNSLFTKINSTLTTVPATLDKGPQGRSRLLEDFRNNRYPNLQLRDLANHIVEFSQDQHGSRFIQQKLERATATEKQMVFNEILSAAYNLMTDVFGNYVIQKFFEFGTPEQKTTLAQKVRGHVLPLALQMYGCRVIQKALESIPPEQQQEIVRELDGHVLKCVKDQNGNHVVQKCIECVDPNALQFIIASFSGQVYTLSTHPYGCRVIQRILEHCTPEQTAPILAELHQHTDQLIQDQFGNYVIQHVLEHGKPEDKSQLINSVRGKVLVLSQHKFASNVVEKCVTHATRAERALLIEEVCGFNDNALHVMMKDQYANYVVQKMIDVSEPTQRKVLMHKIRPHLNSLRKYTYGKHIIAKLEKYFMKAPGSLSSIGGELGPIGPPTNGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSC0</accession>
    <name>A0A6P7GSC0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341571</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148178.1">
        <property type="nucleotide sequence ID" value="XM_028292377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSC0"/>
    <dbReference type="FunCoup" id="A0A6P7GSC0">
        <property type="interactions" value="1955"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647342.1">
        <property type="protein sequence ID" value="XP_050503299.1"/>
        <property type="gene ID" value="LOC126882405"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GSC0"/>
    <dbReference type="OrthoDB" id="193787at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylated CTD-interacting factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148178.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77804" checksum="D9C1A83CC012638E" modified="2020-12-02" version="1">MNEEAEVKDEKLVPMWPPMDSGASPGPQPHVSMPIPTTPQGGAPVNQGFEYELPFELQQQGWKKFWSKRENRPYYWNKLTGESLWEMPVLKPHFDPITDPLGICAPPPPPPGPIPLAHMAPTVAVPIVKRRASEEIGPQAKKLILAGPWDLDVITNVIILERSPCFYMHSHPEIEAYRCSLLSKLRQSYQEVCHSREGIDAPKDSFNRWLMERKVIDTGYDALLPSNCYPEISLSMYKEIMNDIPIKLVRPKFTGDARKQLSRYAEAAKKIMESRNAEAESRKVVKWNVDETFQWLRKTVGATYDDFQDRLAHLKQQCQPHLTETVKSSVEGICLKMYNLSVEYAKKIREKSNNMLKEHGMELPQNMSMHTTRKVWCYPVQFAIGCPRLPVVDYLPDRDQVVLRYHGDTLAINSTHLNKLEHLYRHSCFDDRKFDLFIPRVWVVLKRYATFLGVNPSPNTANADVQDTQQSLPVTVFECLNRAFGVTFECFASPLNCYFRQYCSAFADCDSYFGSRGSFLKLKAVSGSFEANPPYCEELMEASVDHMERLLSDSPEPLSFIVLMPDYREPTPVALQRLETSQFKRRQVIVPAYEHEFRHGFQHVLSKSEMNVRSVHATVIVWLQNSAGHQRWEPSEDRVQALLEAFRPGRERERDRQELLSPTRQGSTSDSKDVVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H0C1</accession>
    <name>A0A6P7H0C1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cuticle protein 65-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114342881</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149485.1">
        <property type="nucleotide sequence ID" value="XM_028293684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H0C1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657388.1">
        <property type="protein sequence ID" value="XP_050513345.1"/>
        <property type="gene ID" value="LOC126889273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028149485.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="16417" checksum="23827424ED837FC2" modified="2020-12-02" version="1">MYIYRGERFCNCTVSQTYLNMNALVLALFATLAVASAAPSWGHGALLAAPVAHGAVLAGPVAHGAVLAGPHAPGAAVIGPVAGASAVIGPRAGGALVAGPVAAPSAVIGPVAGPSAVVGPVNHGALITPAIAAPSVIAGPAVGAWGLGGHGAWGLGAGAWAGHGWAGHGLAGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1X1</accession>
    <name>A0A6P7H1X1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114345075</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151698.1">
        <property type="nucleotide sequence ID" value="XM_028295897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1X1"/>
    <dbReference type="FunCoup" id="A0A6P7H1X1">
        <property type="interactions" value="1265"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657783.1">
        <property type="protein sequence ID" value="XP_050513740.1"/>
        <property type="gene ID" value="LOC126889465"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H1X1"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028151698.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="17173" checksum="A84FDC1326A89907" modified="2020-12-02" version="1">MSGSLTGLTTHTRKVQSLYKRSLRMLENWYDRREVYRYHAVLMRQRFDQNKEIGDIRIAKDLIAKGEAELFENGHWHPRKFPDSPGGVAYGREVPPPDWVVDYWHPLEKAQYPDYFARREQRKKEYVKLWEEKYGKASTFTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H4D8</accession>
    <name>A0A6P7H4D8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114345938</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028152548.1">
        <property type="nucleotide sequence ID" value="XM_028296747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H4D8"/>
    <dbReference type="FunCoup" id="A0A6P7H4D8">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653864.1">
        <property type="protein sequence ID" value="XP_050509821.1"/>
        <property type="gene ID" value="LOC126886799"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H4D8"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="13">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028152548.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="19655" checksum="1BD4716CA6E8268E" modified="2020-12-02" version="1">MDKKAKIELLRANLAEYPDFPKKGILFWDIFSILKEPELFHVLKDVLMETVKEIQPLPECIVALDARGFLFGPILSLELNIPFVPVRKPGKLPGELITSTYTKEYGEDSLALQLNSITNGQRVLIIDDLLATGGTLACAVEMVQKAGGNVIACLALIELEALNGRKLINKDIISLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H5W9</accession>
    <name>A0A6P7H5W9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114344727 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114344727</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151350.1">
        <property type="nucleotide sequence ID" value="XM_028295549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H5W9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028295549.2">
        <property type="protein sequence ID" value="XP_028151350.1"/>
        <property type="gene ID" value="LOC114344727"/>
    </dbReference>
    <dbReference type="GeneID" id="114344727"/>
    <dbReference type="KEGG" id="dvv:114344727"/>
    <dbReference type="InParanoid" id="A0A6P7H5W9"/>
    <dbReference type="OrthoDB" id="6716273at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028151350.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17371" checksum="688F48A46DFE4E44" modified="2020-12-02" version="1">MEKSRRMRLFWFVVMFFNFIFGVTGVIICSLKLKHSDDEEVQAGFFKLSMLFAASNLILSVLLLVAVLKKDQKYAFLYALLIFISLFAATMHIESHTSHDFTYLIIFAVFAFVCFMWFTTYAAYQLWIKETTYDTATATSSQCQTPVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H8V0</accession>
    <name>A0A6P7H8V0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein C15orf61 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114347603</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154088.1">
        <property type="nucleotide sequence ID" value="XM_028298287.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028154095.1">
        <property type="nucleotide sequence ID" value="XM_028298294.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505898.1">
        <property type="nucleotide sequence ID" value="XM_050649941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505899.1">
        <property type="nucleotide sequence ID" value="XM_050649942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505900.1">
        <property type="nucleotide sequence ID" value="XM_050649943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H8V0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028298287.1">
        <property type="protein sequence ID" value="XP_028154088.1"/>
        <property type="gene ID" value="LOC114347603"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649941.1">
        <property type="protein sequence ID" value="XP_050505898.1"/>
        <property type="gene ID" value="LOC114347603"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649942.1">
        <property type="protein sequence ID" value="XP_050505899.1"/>
        <property type="gene ID" value="LOC114347603"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649943.1">
        <property type="protein sequence ID" value="XP_050505900.1"/>
        <property type="gene ID" value="LOC114347603"/>
    </dbReference>
    <dbReference type="GeneID" id="114347603"/>
    <dbReference type="KEGG" id="dvv:114347603"/>
    <dbReference type="OrthoDB" id="9970237at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029245">
        <property type="entry name" value="DUF4528"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34651">
        <property type="entry name" value="SIMILAR TO ENSANGP00000021391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34651:SF1">
        <property type="entry name" value="SIMILAR TO ENSANGP00000021391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15031">
        <property type="entry name" value="DUF4528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028154088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028154095.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17411" checksum="28A32AA008AA9656" modified="2020-12-02" version="1">MVVKIQTRNIFYNFRNKHKPTSSEVLTNYIKQCQEPPWTSYFVKYSSITDDQWGKSHFNWKVGKSNYHILRTGCFPYIKYHCTKRDPQDLKFDDIFFKAIKVLNLGIPCLAYGVSAIFLIRHTETVRMKKGNVDIYFLYPEDKGSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HA00</accession>
    <name>A0A6P7HA00_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 93-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114346134</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152720.1">
        <property type="nucleotide sequence ID" value="XM_028296919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HA00"/>
    <dbReference type="EnsemblMetazoa" id="XM_028296919.2">
        <property type="protein sequence ID" value="XP_028152720.1"/>
        <property type="gene ID" value="LOC114346134"/>
    </dbReference>
    <dbReference type="GeneID" id="114346134"/>
    <dbReference type="KEGG" id="dvv:114346134"/>
    <dbReference type="InParanoid" id="A0A6P7HA00"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028152720.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="46788" checksum="6C1FC62717BE7084" modified="2020-12-02" version="1">MEVIKPEISEETCKVEIENNGLDDGNTYIALLNSYEIKEESNLESTDYSLDCVDLKEFPTKTEIEQDGSTLICFKEEKQRTKEGFSQNGMEIMKSELACPTEQQISANTKETTLKSSIYQCEICCKQLSHAGSLKRHMKTHTGEKPYKCEICFKQFTQAGHLKVHLRVHAAEKPYKCEICFKQFIQAITLKTHLKVHTGEKPYTCEICLKQFIQASSLKIHLRVKHTGETPYKCEICYKDFTSASNLKTHYLRLHTGETPYKCEICFKQFARKYYLAEHMRSHTEEKYYKCEICFKQFSQKVHLETHLRLHTGETPYKCEICLKQFSVTSNLKKHLRVHTGEKPYTCEICFKQFSDSSQLKRHMRMHSGEKPYKCEICFKQFTRRYGLKSHLKMHTGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9X7</accession>
    <name>A0ABM5I9X7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128247.2">
        <property type="nucleotide sequence ID" value="XM_028272446.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272446.2">
        <property type="protein sequence ID" value="XP_028128247.2"/>
        <property type="gene ID" value="LOC114324581"/>
    </dbReference>
    <dbReference type="GeneID" id="114324581"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF6">
        <property type="entry name" value="OSIRIS 19, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046097365" evidence="2">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128247.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="180" mass="20181" checksum="A5717C4222BED703" modified="2025-10-08" version="1">MNPVIITLLFVFAATVANPVISVDNKESNNELFRNDPSLKSDETFLQNVNSIIRNAKSLEQPLDQAETEESRSISSQFEGRKKKIKKIKKTIKKAFLPILIFILVKAIILIPLALAILGFKAWNALQLSFVSFVTGLGLAIWKFCTKVSHDDHVPVVHSGWEYDRADNAHLLAYSGYVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5II64</accession>
    <name>A0ABM5II64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein cornichon homolog 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133360.2">
        <property type="nucleotide sequence ID" value="XM_028277559.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277559.2">
        <property type="protein sequence ID" value="XP_028133360.2"/>
        <property type="gene ID" value="LOC114328642"/>
    </dbReference>
    <dbReference type="GeneID" id="114328642"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133360.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18448" checksum="955E517D397E3AD9" modified="2025-10-08" version="1">MILPDSLLFCVSLLDTGALLFLLIYFVITLSDLECDYLNAQECCSRLNQWVMPKFIAHTFLSVLLLIHGHWILMSLNLPMTFWLIYEIYTVPRGNLGVYDAIEIHNRGQIKKHMRDCMIYLGYYLLFFFLYLYCLITSLLQGDPINRKDEGEIMNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IME0</accession>
    <name>A0ABM5IME0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136399.2">
        <property type="nucleotide sequence ID" value="XM_028280598.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280598.2">
        <property type="protein sequence ID" value="XP_028136399.2"/>
        <property type="gene ID" value="LOC114331122"/>
    </dbReference>
    <dbReference type="GeneID" id="114331122"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF71">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046572324" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136399.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="703" mass="80299" checksum="CB402CE63416896D" modified="2025-10-08" version="1">MSILCLLLVFWLYVFWSHSSAHPLDTIIFKENVTTNFLEVYIPTVNSNNEICKRHSVFVVEEVKKYTLWATEMLDSTTKFPSGFLDGTNYDFGNFDECINVKVLYEEEPFYGKYCLVKFTLKPPFTVNLASENDTYIRHSNLTMWSKMDDYLKDPSKNPRNVIPFAFCIPSSCTNLDLQKSLMEVAGNFNEQVPFLVDVEVDKLTCQVQTYNSKLDSGDVLFILVIAVVICSAGIGSLYYYLVNRSNGRKIICTGTLHNVLLCFAIQSNTKKLTSANNNVDGLNCTAGMKVFSMILIIFIHRSMFDFGADICNPDYVEQMYSNFWMTFVLNGPILVDTFFTISGFLAAYFALLSYQKLNDNSIIIKLYIHRYIRMVSIYTVILAFYCTLFVKTGNGPLWRERVEVERERCRKSWWLNLFFINNYFNTENYCMFQSWYMACDMNSFILVPILTFILFKKPATGILCIVAVIVASMVVTFVTIYTNDEMPILLIYMRMLLHPSENSTFLRVYIPGHIRASSYFVGVLAGYIKYLMGIQTFEIQSCQVKLGWIMCVLLLFISSHFAFIFYVQTVPTWISALYGALYHVGWSMGIAWIIIAVSSGYGGWAVPILSWSPLVILSRLTYSIYLSHGAIQMYSAGIRRKPVYASTFNSVYAAVADVSLGYTLAFVLTILFEAPIIGLEKILWNATSSKTAKKEDQKADHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR09</accession>
    <name>A0ABM5IR09_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139233.2">
        <property type="nucleotide sequence ID" value="XM_028283432.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283432.2">
        <property type="protein sequence ID" value="XP_028139233.2"/>
        <property type="gene ID" value="LOC114333544"/>
    </dbReference>
    <dbReference type="GeneID" id="114333544"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="74"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139233.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30361" checksum="0178D0EEB17756FD" modified="2025-10-08" version="1">MDETWINEGHTVKKVWQDLNIKSKREAFIEGWSTGLKTPSGKGRRLIITHIGSDTGFLDDGLLLFESRKTGGDYHEEMTSEVFEQWFKRILPKLEPGSVVVMDNAPYHSRRLEQLPTTAWRKGRIQEWLTPAIQLLDIARLRKMEYLKYAVDETAKDYGVKVLRLPPYHCELNPIELIWAQVKGEVARNNKTYKLNEVKELLTQAILHVTPEKWAKCIGHIVKEEHRMWELDIHMEVLIEPIIITPGEDDSDSSTASSDLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IV09</accession>
    <name>A0ABM5IV09_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 177</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143060.2">
        <property type="nucleotide sequence ID" value="XM_028287259.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287259.2">
        <property type="protein sequence ID" value="XP_028143060.2"/>
        <property type="gene ID" value="LOC114336866"/>
    </dbReference>
    <dbReference type="GeneID" id="114336866"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143060.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34806" checksum="2A80D40F3E39F8D1" modified="2025-10-08" version="1">MFIKKVAAFMLTDTGKKVSYITAAALSSGALCASYLPHTLLLGEYKKLVQLYKNGLSVPLTKEIESRFQKVLEILEIDPVDRHLYKPFHVVGFDVMSAGSSFSKDGVIIGLPINFSYDNPSTIDRTKMRINHETIIWETEPAQNLLKSLVLSENAQLYAMAREVLHRQTPKPLIDTALNANLVISTYAICRTLNEKFNLYDRPLSLRFGMYSLVALFSIGFYVMLKDVTQVYYEDKVDKELKKKNKIFLEGGKEFYSKLLERNKALRQLLGKEGETLYSVLGNENSLFRNKHIPLVQRLSAFESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IW30</accession>
    <name>A0ABM5IW30_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="8">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="8">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028144779.2">
        <property type="nucleotide sequence ID" value="XM_028288978.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288978.2">
        <property type="protein sequence ID" value="XP_028144779.2"/>
        <property type="gene ID" value="LOC114338386"/>
    </dbReference>
    <dbReference type="GeneID" id="114338386"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144779.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="239" mass="27529" checksum="78E50B1E4178152F" modified="2025-10-08" version="1">MAYRDSAFSEEHPRNLIPELCRQFYDLGWVTGTGGGISIKHEDKIYIAPSAVQKERIKPEDMFVQTIDNKDLELPPPEKKLKKSQCTPLFMCAYTMRNAGAVIHTHSKAAVLATMLFPGKEFKCTHLEMIKGIRNQKTGVNFRYDEELIVPIIENTPFEEDLRDMLAETIKKYPHTCAVLVRRHGVYVWGDTWQHAKTMTECYDYLFDVVVQMKQLGLDPSLTPEQYELKIQKSHTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHG9</accession>
    <name>A0ABM5JHG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 170</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497384.1">
        <property type="nucleotide sequence ID" value="XM_050641427.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641427.1">
        <property type="protein sequence ID" value="XP_050497384.1"/>
        <property type="gene ID" value="LOC126878608"/>
    </dbReference>
    <dbReference type="GeneID" id="126878608"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039139">
        <property type="entry name" value="CCDC170-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863:SF6">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18863">
        <property type="entry name" value="TSEC-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="550"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="800" mass="94108" checksum="06AF396AB13E592F" modified="2025-10-08" version="1">MSGNTEEDWSVFEALCRTTNMDDVDIDIVTSLRSEIAALQYKRDQLQSDMEEMRSQLTSRDQRCLDLKIETDQLREHAARQNAAIASLKKHTQDMEERERNLLAVQARQEHTIQSAHKDLRYSEEKIKELETKIRKLEFDLNAEEQKKESLKLQIQDFVRRLSVALGADLLDFAYINSESLFHKAAELIQETARLRNKICSIQDTLGSVELDLKNCRENLERSLLEKESLHRQCTGQVMEIDRLKQEKQTVEMQHRVLERDFVDAKNELAASNRSLDKATVTIGQHETMICQMRDDLALKEEKIQRLSTDHKHILDSVAILLSTPARFVDSSETSIKDRILELMNDNNDKSAQVERLREKLTAESQQLARYVSLYDQATVKMRSLEDEKTHMDAQLQKADTEINACEISRDALIRDKSTFVNFLERLARALNMDEISQDLGIDLHTETILMRAEQLARLESEKLVDKITKLVFFAEFSYLTQLLVTMTDESKSLIPYDKDDYKYYWPYDKDYYYKYIWQYDKDYYKYCWPYYNDKALCDWYWPRKKTTLIYQLQRRVRNLREQLQRKELHLDLLRRKLSLQEDNTRTKCVIQNERDEANLRVKKLVKQVDRLQLQLAEAKSQIRDLNAQLAEAADYKIISLEKGRKLEDLQKRLIESETLRNKCNRKVTLLKDQVRTTGDTVERERNISEHSIQHLRDDLTRVKENLLDVQRREAQLQNFKHSVAKILNVGMPIPDYDLISRLQKLVDAHHDFTLVSRRYDDPVLRLATRSPTGGSRCTRTPDRSRYDDSGYIDGVDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI66</accession>
    <name>A0ABM5JI66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monocarboxylate transporter 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497633.1">
        <property type="nucleotide sequence ID" value="XM_050641676.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641676.1">
        <property type="protein sequence ID" value="XP_050497633.1"/>
        <property type="gene ID" value="LOC126878779"/>
    </dbReference>
    <dbReference type="GeneID" id="126878779"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="88375" checksum="588662384A3D3A66" modified="2025-10-08" version="1">MGQAESRDDEEDPEKYEGESRRESDNLTDSEVACEEAARLTAEQQEDEFEDEYCYYHDLPPPPDGGYGWVVVFASFMCNMIVDGIAYTFGIFLSDIVFYYDETKGRTAWVGSLLSGMYLSAGPLVSALTNKFGCRAVCISGSIIATIAFVLSIFSPTVNWLMFTYGFIGGIGFGLIYLPAVVCVGYYFETKRSLATGIAVCGSGVGTFTFAPLATALLEEYGWRGANLILAGLILNCILFGALMRPLEYPKDGGEKPLLQRMAEERKLAMERGSIGGSYFMVQLPDGTMEKRQKQPINRDPGVHSSLALDQLAAGSNITPIPTVPTLPTITEAKVTEHSGSSGTPSPRESITEMKSGKKVENGPSETSQRVRRDSDNSAIEVPRNPKIIPRNASQPAFTTHVQGLPKNGSVPTFDRMRKTSFGERFKPTLVPIISSSRNAVNSSNGDMRRKRNDSTGSFISRNISRNASDVDVESLAFTSKLSINSRREPRQMVRPLSRKDIFYSGSVLNLPEYKSQKSLTNYRQSILSIPQIKGEDDGTPGDICPCLVLPDSFKSALSQMLDVSLLKNPVFLMIGISNLFGMAGLYIPFVYLVECAKLDGIDSSKASFLLSIIGITNTVGRLVCGYIADFPQVNALFVNNCCLIISTIAVALTPLCHTYGLYVTVSIFFGIAVSGYISLTSIILVDLLGLEKLTNAFGLLILFRGAAAIIGSPLAGALYDATNSYDVPFYVGGGLFAISAVTSFLAPCLKCFVPSDEPAPGDGDALTPIDEDDEEDDEPITMGGGSAKNVIPTIVETTTSSPDEKEEIQLKESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JI88</accession>
    <name>A0ABM5JI88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 268</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497654.1">
        <property type="nucleotide sequence ID" value="XM_050641697.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641697.1">
        <property type="protein sequence ID" value="XP_050497654.1"/>
        <property type="gene ID" value="LOC126878799"/>
    </dbReference>
    <dbReference type="GeneID" id="126878799"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028054">
        <property type="entry name" value="DUF4481"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN C9ORF91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14800">
        <property type="entry name" value="DUF4481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44312" checksum="D6EA8607C90A835A" modified="2025-10-08" version="1">MSDSETAKPTEEVVLPPPNSTQTEPSPPKIQTKKNWVKFDEDRSANKSADTPAVINTESVQVNIERSLNRSIDTNNVAILDPKPLRNVELPVATVEPIRQGFTNGDIIVTLLPVNTKLPWITPAQFRPELVPEELMAQGLTLTVEEYVQALELLVNDVRFSLYNVCYKRVLVCWITLAFIVLLGLLFSGLQGLLLFGLGIGWLLLNAAAIFLSMYLKFKLQRNLEKCMANVNKQLLRHKIVLALDDRGKISCHKVTLCFIYMDSAPCIAHLQTTIDQQERDQNGGWEQRMDISAQDIIIQGSRTTRLSRKQERATLLYLRYAARWGRDRARGLLNSPPASGGRHCPSQTCPCQFIEEHLLCKPPDYPCKFCIYPSTRADHQDPYLAHNSIGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLP6</accession>
    <name>A0ABM5JLP6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498863.1">
        <property type="nucleotide sequence ID" value="XM_050642906.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498864.1">
        <property type="nucleotide sequence ID" value="XM_050642907.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498865.1">
        <property type="nucleotide sequence ID" value="XM_050642908.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507482.1">
        <property type="nucleotide sequence ID" value="XM_050651525.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642906.1">
        <property type="protein sequence ID" value="XP_050498863.1"/>
        <property type="gene ID" value="LOC126879710"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642907.1">
        <property type="protein sequence ID" value="XP_050498864.1"/>
        <property type="gene ID" value="LOC126879710"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642908.1">
        <property type="protein sequence ID" value="XP_050498865.1"/>
        <property type="gene ID" value="LOC126879710"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651525.1">
        <property type="protein sequence ID" value="XP_050507482.1"/>
        <property type="gene ID" value="LOC126885097"/>
    </dbReference>
    <dbReference type="GeneID" id="126879710"/>
    <dbReference type="GeneID" id="126885097"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="200" mass="23544" checksum="31C6284A51C72DC0" modified="2025-10-08" version="1">MDDNQNQEEDRQSGRKEYRQDLNFVNRDINEDNNIVEMEQSDKGENDGEKNGVKSKEKKYQGRPKKGRKRKFPSQNREIRKKHCIQNKSYFTQKGEMKLKKEFRQYLCKCDCLSKVGIENAKQEYDKFYEVSSHDAQRALICAMVQEGPIKRKRKQNSTKKMHSRVYNINGHVVCKTFLLQTLRISSAKVDNALKSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JP62</accession>
    <name>A0ABM5JP62_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499400.1">
        <property type="nucleotide sequence ID" value="XM_050643443.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499729.1">
        <property type="nucleotide sequence ID" value="XM_050643772.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643443.1">
        <property type="protein sequence ID" value="XP_050499400.1"/>
        <property type="gene ID" value="LOC114330559"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643772.1">
        <property type="protein sequence ID" value="XP_050499729.1"/>
        <property type="gene ID" value="LOC126880092"/>
    </dbReference>
    <dbReference type="GeneID" id="114330559"/>
    <dbReference type="GeneID" id="126880092"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028406" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="130" mass="14259" checksum="B74E8C1547838805" modified="2025-10-08" version="1">MKFVVLCALVLYCSSEVLGNPDKPQCKGIACDIPICPPGYILKYPGPKDTACCPNCEPKPQCERIQCDIPTCSPGYILKYPGPKDTACCPYCELHRQCDRIKCGPVKCPPGSNLRLRPGDCCLSCGPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS68</accession>
    <name>A0ABM5JS68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500787.1">
        <property type="nucleotide sequence ID" value="XM_050644830.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644830.1">
        <property type="protein sequence ID" value="XP_050500787.1"/>
        <property type="gene ID" value="LOC126880773"/>
    </dbReference>
    <dbReference type="GeneID" id="126880773"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="523" mass="60328" checksum="5DC500BB5918C2F0" modified="2025-10-08" version="1">MPKTKKIGTRQFFSYSEDDLKKAIEAVTQNGISRKAAARQFNVPRTTLIRKLYSPATTPRKMGPATELSEAEENVFENWVLAMARKGFPIHRQNLMLSVKKFLEETGRETKYLLNKTPGRSWFQGFLKRHPKIKERYPEAVSKARAAVTQDRIEAWFDEIQLFLEEDRYDEILLDPTRVFNADEAGFCLCPKSEKVLGPVGYKEDFYIRVSSEKEQITVMATFSADGKHVPPMLIFPYKRIPEAIAKSVPENWGLGRSDSGWMTSQVFYEYISNHFLPYLKSNNIQRPVILFVDGHRSHSTKHVSQLCDDNGIILVSLFPNTTHIMQPADVSVFKPLKAGWSAEVRNWKFQNFPKDVTRSTFGTILESVFSKYASEETIKNGFRRSGLYPFNKNNVDYTKCIPNRIVAAQISDKETPKNALDVLENKIEKKYLTEFIQTYSKRETWSGDISYSKLYSVWAEIKMDYENENPQQKEIHPKNIGITSPVAGPSRRQWETPPQKTFATMKKKNQKGLKFQLHLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSD5</accession>
    <name>A0ABM5JSD5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500846.1">
        <property type="nucleotide sequence ID" value="XM_050644889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512901.1">
        <property type="nucleotide sequence ID" value="XM_050656944.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050514170.1">
        <property type="nucleotide sequence ID" value="XM_050658213.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644889.1">
        <property type="protein sequence ID" value="XP_050500846.1"/>
        <property type="gene ID" value="LOC126880824"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656944.1">
        <property type="protein sequence ID" value="XP_050512901.1"/>
        <property type="gene ID" value="LOC126888592"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658213.1">
        <property type="protein sequence ID" value="XP_050514170.1"/>
        <property type="gene ID" value="LOC126889690"/>
    </dbReference>
    <dbReference type="GeneID" id="126880824"/>
    <dbReference type="GeneID" id="126888592"/>
    <dbReference type="GeneID" id="126889690"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="473" mass="56917" checksum="961D2D86A10A088F" modified="2025-10-08" version="1">METRLNKKQKETEERYSEEGIENVDEEISITETTIKESTTEMSTMDRILQMLQIQEENSRRQAEKIKKSIDENSKRQDLGFKQMEQRLEQHKEDVQMYLKQMKHEVEQKTKEISQNLEKHTKKLQNLEKHVEDRDEEIEDRFKKLDKKLLEVKSQHNTGERRQVIIHNGAENKVQFGGDIKKQHPVPFIRMLKNKKQGYEEFEEAKDMIRTHFKDGAALWFESKQNELQDWEEFERKFLRYYWGKEKQMVVNSELQNGKYDEKLGISEEKYALQVYASGQYLNYNYSEEQLVELIARHFDNTMEDYVTLQGYRDMDSLCQFLVVREARRKERRTGRQTENNGNNQTNRTNNYRQSRNENPYRYNGYRDNEGQRYTNNFNQNRYEQNRNGYHQNRFQNSGRNYNNQPYQPNAGRENFNRGNQYNNNNGQGREQNREINSLSFTREGENEQGHQEMDNVEVEINRAGSSFQEGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSN5</accession>
    <name>A0ABM5JSN5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500940.1">
        <property type="nucleotide sequence ID" value="XM_050644983.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644983.1">
        <property type="protein sequence ID" value="XP_050500940.1"/>
        <property type="gene ID" value="LOC126880908"/>
    </dbReference>
    <dbReference type="GeneID" id="126880908"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
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        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="924"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="952"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1042" mass="120867" checksum="B1CED9D284A6D9C1" modified="2025-10-08" version="1">MEVKEEFSENQCKIETVDYEMDNCLLDSVKFEAKEEPKEESIHNTLEYLDLNKIFIKTEIEQDDTLKLFEEKQTRQSGFSCEDIKTDPGNILKQDDDGSNILNQDLTDAMEVNTREKPFIPEIFPRQSTTKPALKVHEKNLNGEKGLSCEICKQQFSYNYRLKEHARVHTGEKPFTCDICNKQFSQGSSLKTHSRVHTGEKPFACEICNKQFSQNSSLKEHIIIVHAREKPFTCEICKKQFSKNSDLKIHLRVHTGEKPFACEICNKQFSQRSTLKGHMGVHSVDKRFACEICIKQFSRSSELKIHLKGHTGEKPVTCEICNKEFARSYDLKIHLRVHTGEKPFACEICNKRFSRSSHLNTHIGSSLCAAIINIHCTIATSKIKYSEPKCTSALIQAKKKKKITSILALIVYWINILLLVKLNQMEVKQEFSEKLCKAELVDYDVDNYLSDIFKTEASEEPKKESAHNTFDYLDFDKICIKTEIEQDDTPQLFEEKQIEEAGFTCEDIKTDPSNILKQYDHESSQLNQYLTDAMEVNTREEPVISEIFPTQSTTKTVLKSFSCEICKQQFPFQSKLKEHARVHSGEKPFKCDICMKQFSKNYDLKRHLRVHTGEKPFSCETCTKQFSTSYDLKIHLRLHTGENPYECEICKQQFSKNYDLKRHLKVHTCEFSCEICLKQFSRSYDLNRHLIVHTGEKSFTCEICSKELSTSYDLKVHLRVHTGEKPFACEICNKQFSQSSTLYTHMSVHSAEKHFKCEICTKQFSRSDGLRIHLRAHSGEKPFTCEICMKQFLRSYALTRHLRVHTGEKPIACEICNKQFSESSNLKKHMVVHSEEKPFSCEFCTKQFSRHNHLKDHRKVHTGEKPFTCEICNKQFRQSSNLNAHMVVHSVEKPFACEICAEQFSRSSQLKLHLRISHTGEKLFTCEICKKQFTRSHDLKTHLRVHTGEKPFACEICNRQFSQSSSLKGHMVVHSVEKHFECEICTKQFSRYSNLKVHSRVHTGEKPPYFACDICSKTFSKKKSLKRHLSENNCHMPSNNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTC2</accession>
    <name>A0ABM5JTC2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501190.1">
        <property type="nucleotide sequence ID" value="XM_050645233.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645233.1">
        <property type="protein sequence ID" value="XP_050501190.1"/>
        <property type="gene ID" value="LOC126881156"/>
    </dbReference>
    <dbReference type="GeneID" id="126881156"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="599"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1635" mass="185530" checksum="E5FEC9BAD8AD5081" modified="2025-10-08" version="1">MALPGNGIFVVKGEISNMMAAMKRGTRWSSHSYQDDDVDSLLRNFQELRDILDNVDDLRFVEPNTFLAPFLNVIRSEETTGPVTSLALSAVNKFLSYGLLDPLHASIPQTIHSIADAVTHARFVGTDQSSDGVVLIRILQVLRTLTLSPEGTALTNESLCEIMLSCFRICFETRLVDLLRKTAEHYLKEMVQLIFMRLPQFSEDLKVSYIKQLKMKPGALDQTRTKRKKQYSSLKKDKSDTDIKSPQTPQGNLAAVAQSSIVDMQGSLQNPENANPVTSNASPKENFKCDVDIIVDSPVSNNEDLKNIDSISSGVEEAATEPKSLTEEEITEEQSPSTQDYINQRGIRFTPQLQQEANLSPYGLACVRELLRFLISLCNPLDKQNTEIMIHLGLTLLTVAFEISADNIGKYNTLLALVKDDLCRNLFSLMNTERLAIFSLDLQVSFLLFESLRTHLKYQLEHYLKKLIEIILSDSPKVTYEHKEIALDNLLQLWRIPGFHTELYINYDCDMYCANLYEELTKLLAKHSISSNTGVYHTHLLSLDALMIITEGIENRCCEEKDRLDAGNSELVQQSNDISFYVGKNSRTKVSPIMPKKEELAQKKSIKKWLPQGTEYFNKKPKKGIEFLQEHGVLKQDIDLDEIARFLRENPVLNKAMIGEYISNRSNLKILQSFVDTFNFVGVRIDEALRAFLETFRLPGEAPTISLILEHFAETWHKANNEPFADVDSAFTLAYAIIMLNVDQHNENAKKQTTPMSANAFKKNLKGVNGGNDFDEEMLDDIYTTIKNEEIVMPAEQAGLVRENYFWKILLRKGQTKDGIYIHDNSGTYDSELFQIVYGPIVAALSSVYEKAENESVHKKVMQGFERCAFIAANLNISTNLDMLILGICKFTVFYNQQKQNNIVVQFGMNSKAQLALRTVFSLIHQHGNTMREGWKHLFDLLLALYSNGLLSKTFVEVEDFIEPSGKLMLVYKEAPSAAKQDTGLLSSLYSYMVSAENLSKIPTPEEQNCIDAAKECIKDCNLEQMITDSKFLHEEALFELVKTLIELSRGPDVHESVAYDYNDNVTVFFLELLIKVVIQNRDRVMTVWQNVRDHIYTLVMNASVFDFQFLLERSVIGLLRIAIRLMRNEEMSHIVLQSLRMLLLLKSSTLSRISRQISFGLYELLKTSAQNIHTNTDWTIIFTLLECVGAGAQPPKPVSSAEDTELKSKSDGETSDNHEEEGTLSDSEGRKSPKDNTQRSQSPVSVVTSPVGTPNTGGWILVGNEGEIQPVMGRTVPPTQYGLALEKNLGSHDPRSMMKCCESLAFLVRDVAHITPYNFDVCVHCIRTFVEASLHGSNFKRLRDSRSRKKTLDRTRTRKSPTSSPDEDDSDDENIPSGYHQISIQLLDLMHTLHTRTAQIFKWWAEEGGEISQETSLWTQGWCPLLQGIARLCCDTRRPVRMSAITYLQRALLVHDLQTLSGSEWEQCFQRVLFPLLSYLLQSINPKDAISMEETRIRVATVLSKVFLHHLTPLLALPSFFNLWLVVLDFMDKYMHADKSELLYEAIPESLKNMLLVMDSAKVFDGPDGKNILWNATWERIGKFLPNMKDDLFKEIEDQNRKNEEVSNIEIIVNKEEKDVNTEKLTTNDNLITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTD8</accession>
    <name>A0ABM5JTD8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501202.1">
        <property type="nucleotide sequence ID" value="XM_050645245.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645245.1">
        <property type="protein sequence ID" value="XP_050501202.1"/>
        <property type="gene ID" value="LOC126881164"/>
    </dbReference>
    <dbReference type="GeneID" id="126881164"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="711" mass="81180" checksum="F027CA9EBA31EA54" modified="2025-10-08" version="1">MVTRRQLFDVLYEKDKLQRSSRTEYLFKYLVRHYKIENDADAMLKMRIFTSKFCNVVYAKLDQCGRKTDRFVKNNTAWLSVCVFEETGLEIDPNAEPQPGTSSGGRRGRPSKEFSASSVRSKRRKTSKLSSTFETEELTLAARRKLKTEGKDDAAKLVSEALLTPTRAGKIRTAWQKAQKSKKIIPLTPDEALSVMIESKDTKHSYLVHRRIAKEHFADIYPSYHKLREAKLRCYPRKEGQTVSESCAEILLQDLLDHTVKRIVELQKPVLRSLSTELLKNLKLLLKWGCDGSTGHSQYKQLFSDNSFGDGDLFLTSIVPLQLYAEQPGQDKIIVWQNPRPSSTRFCRPIRFQFKKETKELTVQETSYIENQISELQPTIGMLDSEEIAVSHVCVMTMIDGKVCNAIMETASSQTCYICKATPKQMNDIEKLLKREVVQENLKFGLSTLHAWIRFFECLLHISYRLEVKVWQIRGSNNRAVFENKKRTIQQIFRDRTGLLVDIPKSGGSGTTNDGNTARRFFADPSLSSEITGIDKDVIMRFGIILRTLSCGYAIDVRAFEEYCLETAKLYVAKYSWYYMPSSVHKILLHGAIVIKEAILPIGQLSEEAQESRNKDLKSFREKHTRKISRISGNQDLLNRLLITSDPVISSLRQYPLRKSSNISSEVVSLLKAPSLESMEADSLRALQLNMESRQVSSSDEEDDSASDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JTP3</accession>
    <name>A0ABM5JTP3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_050501308.1">
        <property type="nucleotide sequence ID" value="XM_050645351.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645351.1">
        <property type="protein sequence ID" value="XP_050501308.1"/>
        <property type="gene ID" value="LOC114341305"/>
    </dbReference>
    <dbReference type="GeneID" id="114341305"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="286"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1383"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1633" mass="185687" checksum="134E76BB5B7252CF" modified="2025-10-08" version="1">MKIHFIPDKVSFSLFTTEEIKKMCVTQIITPLMLDPLGHPLQGGLYDRKLGPYSAKDTLCESCNQTFTNCPGHFGYIELPLPVVNPLFHKIIGTIIKISCLSCFHIQLPTHIKKVLCIQMKLLNCGLITEALSVETALAELISKYEKFENIPTESIKSVLRYEELADETLKNLEGKNVTSQNTETLRNNFVSKMLKEVKSRQLCIFCKNRINRIQALKNRIILTKKKGDLDDSNVVMGQKVTGMESQYITPEESRQYLRNIWRQEKEFLQQLVSVLANVDCEHPTDAFYFEVIPVPPPNVRPVNFVNGRILENKQSIGYKNIIQNVILLKTIIQVVQSKSDINSLSSVEAKSAYSIARGNSPVEKLNYCWEELQSDVNGLLDNENVRQEGQGLKQIIEKKEGVIRMCMMGKRVNFSARSVITPDPNLNIDEIGIPEEFAKKLTYPVAVTPWNVEELRKMILNGPNVHPGAIMIENNGILKRINPYNEVQQKSILKCLLTPEATKGPKGQGIQIVHRHLCNGDVLLLNRQPTLHKPSIMAHTARILKGEKTLRLHYANCKAYNADFDGDEMNAHYPQNELARSEGYNIVNVSNQYLVPKDGTPLSGLIQDHMISGVRLSLRGRFFDKQDYEHLVYQALSFKTGRIKLLPPTIIKPQVLWSGKQILSTVIINVIPDERELINLTSTAKISSKAWQRRPSRRWRAGGTIFLDDKVMSEAEVIIRGGELLVGVLDKTHYGSTPYGLVHCIYELYGGTYAIRLLSSLTKLFMRFLQQEGFTLGVHDILTVERADVRRREIIKDCRQVGKEAVTKALDVPLDTPDAEVVETIEKLSAADPKIRATIDRSYKSSMDIFTNEINRTCLPAGLVCKFPENNLQLMVQSGAKGSTVNTMQISCLLGQIELEGKRPPVMISGKSLPSFPSFEFTPRAGGFIDGRFMTGIQPQEFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLRVGYDMTVRNSDKSVIQFLYGEDGMDISKAQFFNEKQMSFLAENIKVLGNSDTLKQLKNEEDQEAVKEHGKAVKEWKKHHGNPLNHRRNSPFSLFAKYVQNRTGDNNLLTKEKLMKLWYEMDKDIKTNFTDQCEKCPDPIEAVYQPDANFGAINETVQKLIKNYKGFDHKKSKKKFEDVIKLKVMESMCSAGEPVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMMASKNIKTPSMEIPFLQVPDLEYKANELRKLLTRVVVADVLETIDVTVELQFKPIRQYKYTLKFQFLPKKYYSMDYCVNPTKILRHMKGKYFGEMFASIKKVSKINSNIVMMEEERNKKRTTNNEEDEDRPETNEREGDNQIDSSDDEVEDNEDAKQSHKYQETRDDLEPEEEEKEKSDDEDDESDNETQANQKETDNQEQDNEVVDSYNFAQSYYEDQQKQLWCEITFGLPLSFKKLDLTAILKETAGKSVLWETPQIKRAITYVKDDKLMLRTDGINIVEMFKYNTLLDLPQLYCNDIHKVAETYGIEAASKVIVKEVKDVFNVYGIKVDPRHLSLVADYMTFNGTFEPLSRRGMESSASPLQQMSFESSLVFLRNAAIRGREDDLQNPSSSLMLGKPCGTGTGSFTLLHKSFVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU60</accession>
    <name>A0ABM5JU60_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Glutamate receptor ionotropic, kainate 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501474.1">
        <property type="nucleotide sequence ID" value="XM_050645517.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501475.1">
        <property type="nucleotide sequence ID" value="XM_050645518.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645517.1">
        <property type="protein sequence ID" value="XP_050501474.1"/>
        <property type="gene ID" value="LOC114339209"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645518.1">
        <property type="protein sequence ID" value="XP_050501475.1"/>
        <property type="gene ID" value="LOC114339209"/>
    </dbReference>
    <dbReference type="GeneID" id="114339209"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06382">
        <property type="entry name" value="PBP1_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028414" description="Glutamate receptor ionotropic, kainate 2-like" evidence="18">
        <location>
            <begin position="17"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="19">
        <location>
            <begin position="410"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="20">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="867"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="107846" checksum="046B1132951567D7" modified="2025-10-08" version="1">MFFELFLICALPYVLSEDVPIGALFENDDNLEKAFNFAIEDINKNDNDAEFTFTAVVQNNLTKYNTYAVMKNACTILEDGVVAIFGPKTFENIEVVQSICDYKEIPHIVTRWNYWSQRGQIMVNMYPYPHQLSKAYYEIVSSKDWKTFTVLYEDNESLLRISSLIEHAQDIGIAIQILQLDQYNSGNYRETMKTLKLTGQQYFIIDCHIDNLYEVMSQLQQAGLMNENFNLFLTNLDAHTVNLTPFQYSNANITGIRLINPYKDYVQTTTQEYFKEDIDIFKASGWKLRLETALVIDALHMFTEVFKERQKTSSVRIMMNNNSFPCSESSSWEHGYSILNMIRTHSYEGLTGPVIFNNEGFRSNFELTIYELLEGGITDIGTWNSTSGLNISRPSTASEDEDLESLKNMHFIVQITLTEPYGMLRLTTDTVSGNDMYEGYAVDLIDALAKMEGFNYTFVVRQDKSSGNFDKETKQWTGMIKDLLNHVADLAICDFTITSEREEVVDFTVPFMTLGVSILFRKPEDAPPSFFSFADPFGLDTWVCMGCSFLITSLALYLIGRLCADEWTNPFPCIEEPEYLVNQFSLNNSLWFSTGAVLAQGSEIAPIAFSSRTCAAFWWYFCLIMNASYTANLAAFLATQNPIKLFTDLDSLYHNKHGIKYGAKLGGATIRYFANAENESLLWKVGQYLGDHPELLPTENDDGVLRAEQELYAFFMESASIEYATQRHCTLQKYGDNLDSKGYGIAMRKGSLYRKRLTLALLKLQQNHILDDLKKKWWEDRRGGGACQGDTEPDAAEPMKMVNVEGCFYCTIYGTLIAVILVLIEHLLHIIRVGKKTKLPFKEVFIREWHAYIDFNNASKANLMIEEKSQDEDSQKGEEAIEEQQEEQKKSKSKTKSHNSRSRSSSISRARLRQKRKSAMMRGKSTSPMPYGFMIPGSEESFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVJ7</accession>
    <name>A0ABM5JVJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501965.1">
        <property type="nucleotide sequence ID" value="XM_050646008.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646008.1">
        <property type="protein sequence ID" value="XP_050501965.1"/>
        <property type="gene ID" value="LOC114328263"/>
    </dbReference>
    <dbReference type="GeneID" id="114328263"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046256455" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="49"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="256" mass="28864" checksum="1B24C39A685BECE8" modified="2025-10-08" version="1">MILSVLLIAVTFSQLECRRIMDDLSNEVSINPEENFGYSSREWVKISKPPVAVMSKKVGAHMELHCEAMGSPPPTIEWYKANRKITENGAFETNVLTRGPALAEVSSRLVINYLLPRHQDVYRCVAESGTKVDTAPTKLLVTDGREMNFTQLLSAKILGAHHLPRVTFWASTYMEVIGNDLVLPCKYVGNPKPRVIWMDPYSKVIENNEKYSVSQDGELRIRSIEWSDMGQYVCALENSVGEDSIETFLYPMQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JY47</accession>
    <name>A0ABM5JY47_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141116.2">
        <property type="nucleotide sequence ID" value="XM_028285315.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502855.1">
        <property type="nucleotide sequence ID" value="XM_050646898.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285315.2">
        <property type="protein sequence ID" value="XP_028141116.2"/>
        <property type="gene ID" value="LOC114335145"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646898.1">
        <property type="protein sequence ID" value="XP_050502855.1"/>
        <property type="gene ID" value="LOC114335145"/>
    </dbReference>
    <dbReference type="GeneID" id="114335145"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="233" mass="27289" checksum="91ACC3F4CAF1002D" modified="2025-10-08" version="1">MADGSNSKSVLFPILPDNYKEFIGSDVSRRMVEYLKRNNDNPRASFVIFDISSETIPAEFVNRFDHIFGFAVMHWVKNTRQALKNMYKMLKPDGQILLTYTDETSADEVYQDLSVHPKWKRYDHKQLMSPFFMTENAFDEYRKLIREAGFKKSYSTTDYIASKLTDENMFEDFCLSVNPILSMVTNEEYEEYKEEFICRMKNNKLNHTKKSSLTGETCCNTSLTLKIVLLEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0H7</accession>
    <name>A0ABM5K0H7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503693.1">
        <property type="nucleotide sequence ID" value="XM_050647736.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647736.1">
        <property type="protein sequence ID" value="XP_050503693.1"/>
        <property type="gene ID" value="LOC126882745"/>
    </dbReference>
    <dbReference type="GeneID" id="126882745"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70461" checksum="D870607625A2CFF0" modified="2025-10-08" version="1">MPESKETKESEKLRKSRESVRNRLDTFAKYIDKIAIPGSSDNLPVTELSVRLDRAETIIEEFEVVQGKIDALVDDVSVEIKYREDFENVYFSTIAKAKELLQPKPIISSNENANQSSVSDRNSSFNSGIKLPTLHLRQFSGNYSTWLDYHDCFDTIIVKNNDISDIQKFHYLKSSLSGTAEKIINSIKVSAANFTVAWKLLCDRYSNEPLLIHNHIKSIFNLKVVNRDSSKCLQHLIDGLTSNLRSLESLGEPVSTWDSIIIFIILEKLDPETVKDWDKESQGNAPTSVKPTLDDLLKFLQHRADTLEKFEARSIKGGSSSKDHSHSSSHRSKTHTSQSFINNGASSDLCPHCNGPHKMSTCTSFQNLDVHARMREVKRVRACFNCLFIGHQNTSCKYGKCKKCGKKHHTLLHVNAENSNSPNDTQSVSSDNQTPQTLSCHAVQNSFALLSTVTVQIPDRSGVKHNCRALLDSGSQSHFVTYSLVSKLGLSKEPADISVVGVTQISSRIKHMRCENEKESAITEWIEADDNGLQKFTNEDIVNLVQPEGNSNEDEESQEEVSLPYRVSHANFTKALDVDLPYVEQNCAAFSVNVATLPCTRRQLSTSLRMRFSAANVLAKVRTIFLDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0N0</accession>
    <name>A0ABM5K0N0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503738.1">
        <property type="nucleotide sequence ID" value="XM_050647781.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503739.1">
        <property type="nucleotide sequence ID" value="XM_050647782.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503740.1">
        <property type="nucleotide sequence ID" value="XM_050647783.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503741.1">
        <property type="nucleotide sequence ID" value="XM_050647784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503743.1">
        <property type="nucleotide sequence ID" value="XM_050647786.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503744.1">
        <property type="nucleotide sequence ID" value="XM_050647787.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503745.1">
        <property type="nucleotide sequence ID" value="XM_050647788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503746.1">
        <property type="nucleotide sequence ID" value="XM_050647789.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503747.1">
        <property type="nucleotide sequence ID" value="XM_050647790.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647781.1">
        <property type="protein sequence ID" value="XP_050503738.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647782.1">
        <property type="protein sequence ID" value="XP_050503739.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647783.1">
        <property type="protein sequence ID" value="XP_050503740.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647784.1">
        <property type="protein sequence ID" value="XP_050503741.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647786.1">
        <property type="protein sequence ID" value="XP_050503743.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647787.1">
        <property type="protein sequence ID" value="XP_050503744.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647788.1">
        <property type="protein sequence ID" value="XP_050503745.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647789.1">
        <property type="protein sequence ID" value="XP_050503746.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647790.1">
        <property type="protein sequence ID" value="XP_050503747.1"/>
        <property type="gene ID" value="LOC114326616"/>
    </dbReference>
    <dbReference type="GeneID" id="114326616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF21">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 11, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028421" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="301" mass="34635" checksum="6FD7CFC996DA7DB9" modified="2025-10-08" version="1">MESSRLLIYTLWMLIFPELFTVFHEGEAAYAVKRFTGLYTGPYFDPTTTTNITTQLGTHAYIPCKIKQLGNKSVSWIRRRDAHILTVDRYTFIADDRFQAFFVEATDTWTLQVKYVQARDAGQYECQVSTEPKMSHFITLNVVVPKIEIEGESDIYVKRGSTVQLKCVITQSLEEPAYIFWYHDGERVLKYDQSAIDIRMSRKGTDTTISTMTIFRTRPEDAGNYTCSPSNLDSASAYLHVINGSNVEYKEIVEDCYMFLVWTHGHALQRYISGLNSSFMIKILPYSRSQCPIPGLYLKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1D7</accession>
    <name>A0ABM5K1D7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the attacin/sarcotoxin-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503998.1">
        <property type="nucleotide sequence ID" value="XM_050648041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503999.1">
        <property type="nucleotide sequence ID" value="XM_050648042.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648041.1">
        <property type="protein sequence ID" value="XP_050503998.1"/>
        <property type="gene ID" value="LOC126882958"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648042.1">
        <property type="protein sequence ID" value="XP_050503999.1"/>
        <property type="gene ID" value="LOC126882958"/>
    </dbReference>
    <dbReference type="GeneID" id="126882958"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005521">
        <property type="entry name" value="Attacin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03769">
        <property type="entry name" value="Attacin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028429" description="Attacin C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin C-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="163" mass="17837" checksum="D7BB35BD01FC3A58" modified="2025-10-08" version="1">MKGLVIFAFCIAVVVSLPLDLIEDESGQEYLVVPVHRERRDLTWGANQNGYTLGQKGNLWENGAHKFDGAYTGSKAWDSHGLKPDSFGGRLEYTNKPTKTTAFVGADRTPGYGTDLNAGVKYNFVQDKKLNIDLTGQVSQHQGGPFGNSKPEAGVYLNFNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4S0</accession>
    <name>A0ABM5K4S0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505186.1">
        <property type="nucleotide sequence ID" value="XM_050649229.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649229.1">
        <property type="protein sequence ID" value="XP_050505186.1"/>
        <property type="gene ID" value="LOC126883580"/>
    </dbReference>
    <dbReference type="GeneID" id="126883580"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="188" mass="21523" checksum="DE1448D1E949D522" modified="2025-10-08" version="1">MERQAKEKAEGHEKDPQQEPEEEVIRGEEDASSSEEEEEITEDNDYNTESEIELNDKESSDSDNESDGESLESDEDEYFIAKDNQTKWYKNSVEHAPNSQTISAPENTTENAPNSVYYGQEANSPIANIPQNQFIFPAQLQQFPLQSQPMYHVQNNPSTAEQTSKRQINLENIHSENSDIEFSEEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K518</accession>
    <name>A0ABM5K518_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505279.1">
        <property type="nucleotide sequence ID" value="XM_050649322.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649322.1">
        <property type="protein sequence ID" value="XP_050505279.1"/>
        <property type="gene ID" value="LOC114328435"/>
    </dbReference>
    <dbReference type="GeneID" id="114328435"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="277" mass="30950" checksum="F3764F67F8C4ECDD" modified="2025-10-08" version="1">IILCNSSILSSINTISSPILAITQYSTEEYIDGSLVFVCFSLVEDLFPCIFFIGSVVVFFVFPLGILICVYALIATSLMSQPLAMIASRNLTSPAQNVIKYRKQVILMLGTVVLAFFICLLPFRALTLWIIIAPAGSSFELGFERYYNILYFSRIMFHINSAVNPILYNIMSSKFRGGFFKLCGAKSLRKRYLKKPEITRKSTSSSTHTSSQQTSETFLKSSRTYSRQSSSLKEVKEEDETSKVPGKNLVKNVYVRAPIEIVAGINGEKLPSGEIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6E5</accession>
    <name>A0ABM5K6E5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleic-acid-binding protein from transposon X-element</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505761.1">
        <property type="nucleotide sequence ID" value="XM_050649804.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649804.1">
        <property type="protein sequence ID" value="XP_050505761.1"/>
        <property type="gene ID" value="LOC114337219"/>
    </dbReference>
    <dbReference type="GeneID" id="114337219"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31232" checksum="C31AECBD9442EF17" modified="2025-10-08" version="1">MIEFDGELDKTPLTTNVNTIKTARQQGTTENTSIINDGSVTLYITSCENETPNLCIDKLKTVIPKLNVTSTVQTEYGLIINLQNDTFLQKVLQMDLAKIFGGPVQAVSLYSGQYKKIVRFKEIPWCIRNEEIENCLKRQGVSYSKLTRKKSTLYVEVSDFTNYQRLREEGINFYDSVVLRSSEDGGLNEEVYCNNTNIIQCYKCQGFWHKANTCKQNIRCVRCGEEHLVEHCDRPKNSPICCNCKGPHHAAYKLCPVRLKLQKSVRVSFSFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6F5</accession>
    <name>A0ABM5K6F5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cathepsin L1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505771.1">
        <property type="nucleotide sequence ID" value="XM_050649814.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649814.1">
        <property type="protein sequence ID" value="XP_050505771.1"/>
        <property type="gene ID" value="LOC126884025"/>
    </dbReference>
    <dbReference type="GeneID" id="126884025"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045825798" description="Cathepsin L1-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="113"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36051" checksum="7DFBC85AFDAB3967" modified="2025-10-08" version="1">MQVFVVIAALIVAISAGLHEDYEEWISFKVKFSRKYGPAEDKSRFQIFQKKLREIEQHNEKYAKGEIGWKQGVTQFTDWTEEEFEAILDKQLATEPVLEDSLGVYKADPNELLEASVDWREKGAVLPVRHQSKPRDCGSCWAFSAVGALEGQVAIHKKQKIPLSPQNLVDCTRNYGNRGCRGGWPVRSFQYIQKEGISSEADYPYVAKDETCKKNARKSITRISGYKKVNPTEKDLISAISKIGPISVLVGASPWTNYVGGVYDNTNCGQINHAVLAVGYTDEYIIVKNSWGTEWGEGGYIRIARGKNICSINNQNSYPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KA93</accession>
    <name>A0ABM5KA93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050507108.1">
        <property type="nucleotide sequence ID" value="XM_050651151.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651151.1">
        <property type="protein sequence ID" value="XP_050507108.1"/>
        <property type="gene ID" value="LOC126884849"/>
    </dbReference>
    <dbReference type="GeneID" id="126884849"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="657" mass="75086" checksum="FF63531F9E917DBF" modified="2025-10-08" version="1">MEKFLVHKTKKMNPDSEASSSKRQRPESPVPVCDKIGSSSLSQSPSTDKKFNKRRKSSTVWNYFKRSSNGKLAKCTTCGKEYKTSGNTSNLSDHLARFHPIRSYNGVQEVSTSSDNANYTTTTAKPNVVSVSSFFKRETHYDSQSERKKLLDRAVVEMVCLDYQPFTIVEDVGFRQLVYKLDPRYVLPSAFTVGGKLLSEFYTDISNKLQDILRNIDFVAITCDGWTSRAMESYVTVTCHYVDEDFKLNAVVLSTKPLTNGIHHTAENIAETLSEIFNEWNLEQKVSCIVTDNAPNYIKACKLLKKRHIPCYAHTLNLVVQDNLKYVQDFITKCKDIVTFFKSSNIATKLFKKEQEQDRAQQYQLLQEVSTRWNSTYYMVQRVLTTNDAIGRTILKLRKPPQPLSVDDIIVLTDVQKVLQCFEEATKKISGSEYVTISLVIPITFGIYNILTQLLPELASEEGKIFCKKMIESVRTRLFPYELRTATRVATLLDPRFKKEGFRAKENAEAAATLLEQDMYSFMKKRQENSISQDNTEEISKTQTNTTRSLLGFLGERIGEKVKSVTADVIITKRQYLERTNSDEQSDPLLFWKVTGKELTPMEDCVNQYFCIPATSVESERTFSATGQIITDRRSNLNPEKVKMLTFLHQNFSAVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAC1</accession>
    <name>A0ABM5KAC1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507133.1">
        <property type="nucleotide sequence ID" value="XM_050651176.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651176.1">
        <property type="protein sequence ID" value="XP_050507133.1"/>
        <property type="gene ID" value="LOC126884864"/>
    </dbReference>
    <dbReference type="GeneID" id="126884864"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="113" mass="12729" checksum="A0BF1EEF5F472966" modified="2025-10-08" version="1">MAGRHFRKKYFDFNKPEAVEALMNIINDDLELEGFRDDSDSDLTWCKELNSLLKRLGNSDSSDSDQEEDTRENSLIQNKNPPFQNDTKVPGPSGISAAPVLDQPQTTEDLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAD2</accession>
    <name>A0ABM5KAD2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507151.1">
        <property type="nucleotide sequence ID" value="XM_050651194.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651194.1">
        <property type="protein sequence ID" value="XP_050507151.1"/>
        <property type="gene ID" value="LOC126884885"/>
    </dbReference>
    <dbReference type="GeneID" id="126884885"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="41974" checksum="3CD183ADEC9FD092" modified="2025-10-08" version="1">MGVIKEVCAFFHKSAKRTEVLKLTITECCPEQKKKKLISLCETRWVERHDSVLLFKELLEPVSLSLLKIEEESSDSAPKAHALGSSITQFQFLVNTFVLSHMLSKTHNLSENLQKKNLDLTQAVKNVSNVLDLLSKERENADNNFKVLYSQIQERVDKLKIKEEVPRICRLQTARNNVPYSTQEEYYRRAVYLPYLDDFCNSLKERFESHKETVASLQNILPEFCIKTDFCALEPAFNSYEEDLSHKEVVESEFMLWKERWSQEKYENLPKSAVSSLEKCDQDFFPNIYVLLKLLAVLPVSVATVERSFSSLRRLKTYLRNSTSENRLNGLALLSIHRDFAISNEEVLDKFASVPRNLDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBE0</accession>
    <name>A0ABM5KBE0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sensory neuron membrane protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507504.1">
        <property type="nucleotide sequence ID" value="XM_050651547.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651547.1">
        <property type="protein sequence ID" value="XP_050507504.1"/>
        <property type="gene ID" value="LOC114340631"/>
    </dbReference>
    <dbReference type="GeneID" id="114340631"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF69">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60443" checksum="F9EA55EA9075FF6F" modified="2025-10-08" version="1">MKLVEFQKLFYLISTVITTKFNRKMKLRFPVKLAIGSVFALFFIVLVGFILFPKMIHSKVKSMVNLGPGMEIRGMFLKVPFPLSFKIYVFNITNPMEIQNGAIPEVKEVGPFCFQEWKEKVDVHDEEDNDIITYLSKDTFTRTSGPGCVSGQTVVTIPHPMILGLVNAVSRAKPGALSLINKAIKSIYANPTSIFLTAKVDDILFDGVVIKCGVTDFAGKAICTQLRGSGSLKIIDENDLGFSLIGPKNATEQKRIKAIRGTKNHHDVGRIVEYDGSPAMSAWPTEECNKIMGTDGTVFPPMMTKEEGLVSFAPDLCRSLKAFWVKKTKYDGIPVNEYTASLGDSSKNEAEKCYCYTPDTCLKKGLMDLYKCAGVPIYVSMPHFYDSDESYVKGVKGLNPNKKEHEISILFEQMTGGPVSAKKRLQFSMPLEPNQKVDLFKNFTTTVIPMFWVEEGVDLNNTFTKPLKMLYTMKKVVNISKYLILSGSIVGCIAAAYLFFKNNDKVTITKVKDVQKVPAPPSGISTVNGHTNRAMSENEVDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCJ4</accession>
    <name>A0ABM5KCJ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507912.1">
        <property type="nucleotide sequence ID" value="XM_050651955.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651955.1">
        <property type="protein sequence ID" value="XP_050507912.1"/>
        <property type="gene ID" value="LOC126885391"/>
    </dbReference>
    <dbReference type="GeneID" id="126885391"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="933" mass="106835" checksum="8FC12D337E0928A2" modified="2025-10-08" version="1">MPPKRKGGQEKKLEREKKKRCEIAKKCHSLDNLLNSYSVFSTSGVESDINTEKQEQEQKSEENLPVSETKFETELKLSDDSDDDIETSDESDSEANVKKALKDEEALLKLGQPEETESGNFFDRPDPNKLQLFFEFHPKVPVAQKDVPFNVEKAFTRNNKTKRKWLSYSEERKALFCTICLAYSVESNKDQSSAFARGMSDWKHVYQRINEHESSISHGKNCETYFMYIKNQTIEKILFGNVVEMRNKKVASNRHVLDVIIDVIKLIGKRGLSYRGTANEAAYNLENENLDHGNFLEIILLLSKFDVILKKHLDAIVKKSKSYHNRKIKRRAGNFYTFLSKTTVNSIIVIITEIILKKISSEIQIATMFSIEIDSTQDISVTDQCSVVTRYVYNGTIHERLLAVVPCHNSTGKGFHTMIHDILVKNGLDEKNCIADSTDGAANMQGRYSGFSSFMVQENSNHVHVWCYAHILNLVLTDIFKSHIKAASFFSLLNCIAAFFKESHQRMGYWLDIGNNARSQKLQLIGETRWWSKEAALSKIFGNFNEPNKALYVDLIDILNTIENSQKIKSDARATAANYKAQLLKYENILIGHIFLKLFSITGPLSRYIQTTGLDLLKCNFMVNDSILSLKKMQRNFPDIEASADKFVGWAKLSFERRDFEFFVEEQLPEFRSKKKKKFFDEKTSDEIPVSPKENFRIVFFNVIADTAVESISRRFANNAELCRDLNILDPNNFEEIAKGELPENSLKILSEKLIQFHSSATPAKLKEELASFASNWKHIKLTIEDSYEINYARLDVGLDDSSSAQSDVDEDDCITKQSTKSRVCIESNKCQNCVICCYGSILKYNLFKGAYSTLVLAYQYILSLPISQVACERSFSTLKFIKNRLRNSLSDNRLESFMLMNIENDILSDINNDEIINRLGQTTKLMKDALMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCQ2</accession>
    <name>A0ABM5KCQ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507966.1">
        <property type="nucleotide sequence ID" value="XM_050652009.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652009.1">
        <property type="protein sequence ID" value="XP_050507966.1"/>
        <property type="gene ID" value="LOC126885439"/>
    </dbReference>
    <dbReference type="GeneID" id="126885439"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="721" mass="81485" checksum="3574123E565A164D" modified="2025-10-08" version="1">MSDQNKTKRMATKGALTRLTTYFRSIENNEIIDLVDLEMRLFKAEGLLDVFNEVQMHIETDDPDCEENYDTLHAIERQTFEDRYFKIISDIKKLILSRRPTETSDSRSVNGSIAARPTNTSNIKLPPLNLATFDGSFDQFLFFRDSFNSIINDDTSLSNVQKFHYLRLSLRGIAADTIKSLQVCDANYDIAWSLLIERFENKQLLVNNHIKALFNLPLVTKESNQGLRQLLDNTQKHLRALEVLKRPTKHWDDLIIYLLTTKFDNSTRRSWESQNCKDNLPVLDDLLKFLKERCRILESLDNYNDNKQDQNSPRYKGNKSETRAFVSNTENRFKCNFCTKEHKIYYCPDFLKLNPTNRLNNAKRLRLCLNCLGTCHRTKDCRSTGCRKCGKIHHTLLHFENSQSSNSVSTENNSSQSSLPSNVPNTGLQSNESTSTSNFSSTHHISSSVHTAIKPYILLSTAVVNVFDKFGNSHKCRVLLDNGSQSNFISEKFCDILQLSKEKINTSISGINQLTHNINFRTSLTFKSDINNFSKKISCLILPNITSNLPYIHINRSQLNVPTKLLLADQNFEKPGPVDLLIGADTFWDILSVGQIKLGPGLPIIQKTTLAYALLEAKFCKKCSKVGHFSKVCRLQKSNSASAAVLATTTSSSNVRNLAAAPQCLSKSVTKIKVNGNTAKSLIDTAQCTSNHRLWPPTADPIRDEDHENPGAESHSGSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDE6</accession>
    <name>A0ABM5KDE6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508205.1">
        <property type="nucleotide sequence ID" value="XM_050652248.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652248.1">
        <property type="protein sequence ID" value="XP_050508205.1"/>
        <property type="gene ID" value="LOC126885621"/>
    </dbReference>
    <dbReference type="GeneID" id="126885621"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="255" mass="29219" checksum="EDF6A519DD1674FF" modified="2025-10-08" version="1">MGTNKIGRTCPSTMIVTSNQECISVVFFPVHVGHYNELGRLRIDETDRIKIAGKLSQGVPIGRVILEKVHPVERVHLIEKKDLTNIVRDFSIGYTIKRHKNDAVSVQLWVKAMQLLENNPVLFYKNSEEDDEGVFDKNDFVLIIMTEFQKKSLISFCQDKICIDGTHGLNQYGFQLYTIVIVEEYGSGVPAAFCFSNRSDETLFQHFFQCIKDSVGLLSPNVFMSDDYNAFYNAWKSVMSEVPNRLGTKFWKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDW0</accession>
    <name>A0ABM5KDW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508353.1">
        <property type="nucleotide sequence ID" value="XM_050652396.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652396.1">
        <property type="protein sequence ID" value="XP_050508353.1"/>
        <property type="gene ID" value="LOC126885687"/>
    </dbReference>
    <dbReference type="GeneID" id="126885687"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1063" mass="122385" checksum="10F86E60EADBB435" modified="2025-10-08" version="1">MSIICEEIFDEISHPSEEEIKDYAVKIGIDPDSEPQLLPIAAEGLMKALPAGWKPVYDDKSKSYYYYNNLTKKTQWEHPLDDIYRGLVKKARTDSQSLSIHDNREDATYVTDDILSLDEPISNVPSKKLDPVPTGTKKKLAPLKLSPNASPKKDFKLFKQKSEDFNVGPKKLSLGFSSFDDEKESASAFDRHPRSMELKVMGGGSMFLKSNTLRKNSDVGINSLSTKTELSQDLQPRSILREKNSMEHSKSLEFDKLIVDKSEKDDDDKKSVRFNLDNNTDIGITFSDKSSSEEELATSDKNKPEDIINVKITPSKNRFSVHPVLEPLKPTSLKLIKPNPKDFIKPKLTLNKGSDSDEETHSLEKSGIDHPDVLFESDNSESSSEKIAEKSKKLEEKAGKKVEQLKQDIWEEKNKEILKFKSDLETSHKQEVKRILEDEKIKQDQVIQEEVKKLKEEWNLEHKSAIDEEKTKMNEKLENIKTELDCKIKIEEEKLKENFDSKKDELEKYYEEKLVDIEKELAEKVEKNRDELVFTHNSDVDQLKQNHSIIIEELKRQFDAEEQVLRKAHQAKMAELRSKFQAESEQDRSKHTTDERTFEKLRCEKRLLEDKYRCLKEKYLKLKTEIKLTMEKRSKRKEQSTTTNTTGSETEQSNSNNRDRKVLDKPPTPKHSKNASVEERPKSETRTVKQVVIQDLDTSVSDNCYQSDDKTNQNDSSDSTNPGRSRKKIFSRLKSSSTSRINNNSKQRKPQRSCSPVENLRRQLQKLEDLEDQFPENAQADTYHLRYPFSDGQKFEGSSELEFFRHRIHLERDSIKRAKESLRSQKSLFQQRQKELKLKHGTMARHTLQQLCQEEKELTDMEVNLHRTRSLLGEKVIRLRHLEQSLQRANVQNDQNHEDATLSDISSHSASSGISSTEFAITDYAKGILNREKFQESSEIIQSLENLNSEIREIWDVLRKQQQQTNIQQVIPPLVYPDLGWPVLAASATNVQPAPPSIPTLADRLHNYRQHLALANAQSTVVTHATQGATTTLVERTRNLRHWLKQTGIDVGGSETNPPQATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG09</accession>
    <name>A0ABM5KG09_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509136.1">
        <property type="nucleotide sequence ID" value="XM_050653179.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653179.1">
        <property type="protein sequence ID" value="XP_050509136.1"/>
        <property type="gene ID" value="LOC126886306"/>
    </dbReference>
    <dbReference type="GeneID" id="126886306"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="93"/>
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    </feature>
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            <begin position="94"/>
            <end position="121"/>
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        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19960" checksum="92F7A2B6DB4B505B" modified="2025-10-08" version="1">MLTHTGGKPYKCEVCLEQFTTALTLKTHTMTHTGEKPYKCKICQKQFIQAHDLKAHMMTHTGVIPHKCKICLKQFTTASYLITHMMIHTGVKPFKCEVCFRQFSVTSQLKLHMMTHTGEKPHKCKICLKQFIVPRVLKLHMMTHTGERPHKCDICLKQFTASSGLTRHLRTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI41</accession>
    <name>A0ABM5KI41_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neprilysin-2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509786.1">
        <property type="nucleotide sequence ID" value="XM_050653829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509787.1">
        <property type="nucleotide sequence ID" value="XM_050653830.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509788.1">
        <property type="nucleotide sequence ID" value="XM_050653831.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509789.1">
        <property type="nucleotide sequence ID" value="XM_050653832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509790.1">
        <property type="nucleotide sequence ID" value="XM_050653833.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509791.1">
        <property type="nucleotide sequence ID" value="XM_050653834.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653829.1">
        <property type="protein sequence ID" value="XP_050509786.1"/>
        <property type="gene ID" value="LOC114336678"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653830.1">
        <property type="protein sequence ID" value="XP_050509787.1"/>
        <property type="gene ID" value="LOC114336678"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653831.1">
        <property type="protein sequence ID" value="XP_050509788.1"/>
        <property type="gene ID" value="LOC114336678"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653832.1">
        <property type="protein sequence ID" value="XP_050509789.1"/>
        <property type="gene ID" value="LOC114336678"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653833.1">
        <property type="protein sequence ID" value="XP_050509790.1"/>
        <property type="gene ID" value="LOC114336678"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653834.1">
        <property type="protein sequence ID" value="XP_050509791.1"/>
        <property type="gene ID" value="LOC114336678"/>
    </dbReference>
    <dbReference type="GeneID" id="114336678"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="88"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="542"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="86807" checksum="5ECAE0C392DB2F21" modified="2025-10-08" version="1">MQNLKNGAILPSSAEASEHGCSRNKKRKVIIAVCVVGLVLLVAGLFYLGFSGIWTSNRDNVKLETCTNSSCVHAATQILQHIDIRADPCEDFYRFSCGNFLQNTHLLDNRESRSGSRSVEDIAQDEIQSQIREMLERPILREDPKSFNTAKKFYRACMNETAIARQGLKKIKEILEMSVGWPTLHGYNWDDKKFDWMESVHKLRQLGVSSDVFFRVTVEKDDRGANSRYVIGIHDIPYAELKPNHESRDLLLEYMREIAVMFGADREVAIKDANDTLESLDKLGQIEKDSYLVNKTKPQIERRALSELQYKYRDIQWHHYLSGLLTPATNVNYDDEVIIWRIRYVELMETFLAVTSRRSLANIVAWHTIQELIYYLPEEFAQKTQELIERMNRRLVNFKLPRYKTCLIETEKSLGSVLAAAYIQNSFSENKRYKAMEMIANIKAQAEEIITRSEWMDGITKELVIQSLRTSVEKLPSTGDLLNLLEENKSLYAQIRINESEYLEAVLNLRLVQLYREQSKLRNTYEEEPFSELYTVSGVKIHYSPKENQLTFPVGIFGGVYYQNDRPEYMNYGILGSIIAHEVSHIFMRAARGDQAPRELRSWWSPNSLANYDQKLQCISNQYSNFRLTELRQRHLNPAETLDEDMADLAGMKISYDTYINWSHKNGAQPLLPGLKYSPNQLFWISAAIRHCSKYSQEGLERYIANYRTTNTSPQQFRVNGPLQNLNEFAFDFGCPVGSKMNPENKCNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIU3</accession>
    <name>A0ABM5KIU3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510136.1">
        <property type="nucleotide sequence ID" value="XM_050654179.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654179.1">
        <property type="protein sequence ID" value="XP_050510136.1"/>
        <property type="gene ID" value="LOC126886974"/>
    </dbReference>
    <dbReference type="GeneID" id="126886974"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="793" mass="91929" checksum="EB73F965D3456424" modified="2025-10-08" version="1">MWVGYNAKISNDNSTIQKIDYLTQINDSPTDPRVIKETMRLSLKIASECGKKYFNVTYDLAIAKIALKIQSAEEEFKNLFIHLGSFHIMLSFFKAVGKFINGCGLTNMLVDAEVLANGSINTFLTGKHFNRCCKIHPIISLALQLLHVEFFLENKQYDLETIKTYLKHYSENENENPVINNELCHKIFEDYAQFKKDTLQGNHGKTPQIFMMYIQLIDYYLMLEFSIRTANFDIYKYVLEKMTNIFFAFNHQNYARYLTIYLNKLEKIEETHPGLIQEYGDCFFGIRRTTKPFSRNPIDITLEQTINAHAASRSSGIINMTNSVGARQKWAITHSLRTNMISKLMDFCNLYSKDDITKDLRKSSICHSNKNVENLLTIIQQCTNPFSSNLSQENLYNISSGQSVSEDIYTFLSNIETTGELQRIKFITESQIDPERFDKAILKNTVVNFASKCVKKVKINGKVKEVTIQRDIFGRLLYASLQSHIDLKEALKYPLTPIPFSLCHSDGSICKTQKSVIFEELKSYQEENGNPPKADIHIYDGFYLLHTLKNVPNTYGKISMYIFKLLVSDKKEVHIIFDKFNDPSIKDYEHRQRGEDDTVHSVHKNNKRPSDFGKLLRSKNFKESFVEFLIDDWTDDCFVILCQDKIVKLSYGTSCYSYQVHENHIKKTTDYNLCCFHEEADTKIMYHICQLPNNYNVEVHCTDSDIPVIILANMKYLKADIQITVNMCSNKKREYLNMNKIYQGLGDKLARALTVCHIFTGNDFNPAFYRKGKKRPFAILKKNNRIKMLLCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKR9</accession>
    <name>A0ABM5KKR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOC3-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar complex-associated protein 3-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510795.1">
        <property type="nucleotide sequence ID" value="XM_050654838.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654838.1">
        <property type="protein sequence ID" value="XP_050510795.1"/>
        <property type="gene ID" value="LOC114331221"/>
    </dbReference>
    <dbReference type="GeneID" id="114331221"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="454"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="791"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118760" checksum="AF292F198C9C13DA" modified="2025-10-08" version="1">MEFEIEEKFVEHDQRSIHSRLSTSTEFVDFKNELVEDKSAMELQLKIEEEFVDHKEMKNEPEEEYGSAIEVKVEPKEEFAGDVEGCIEPHLITSLDLKNLNNEQCEDNLGLSYTENRMEIMKILPEDSFNKNQISPDSEEVPLTNLNGHMNIETGERLEQNKSMELQFKIEEESVDYKEMKNEPEDEDGSAMEVKVETKEEFARDVEGCIEPHLIMSLDLKNLNNEQCEDNLGLSHKNRMEIMKILPEDSFNKNQISPDYEEVPINNLNGHVNMKTEEGPEKNKCLSYKKNRMEIMKISPEDSFNKNQISPDSEEVPINNLNVTIQTGEGPEKNKCEICFKQSEGPKSKKRKLTDDDSLENQYEAQLDEGESDKQVKNLLPIKTKRGIIPMQTLEPIQDEQDEEASDVNNEEEVIEETEPEGNNFSLESTGFDTGEPISAAQLLAKRNEVINKMKIHIGTLSSGLLENPEEKVLNLRTLLSLMDEEAAQLYITVKKLITVSLLEVFKDILPSYEIKNLMPDGVKLKKDTLKLQKYEENLLLYYKKFLQKLEKYALVLFKKRGDTRKRSEEELTLGVLAIQAMCELLITHPYFNFSQNIAQAVVPFLNNRDKSVRELVKTSVKTVFKEDKKDEITLKILRIINNYLKNHLHVHVDMLEVFLVLNLRDVNLDQEKEQDMKQKKLMSHKSRLLQMSKKERKRKKKLKEVEKELMETKAEENKQVKQKNLTEITKIIFNVYFRILKTSSDTKILGVCLEGLAKYAHCINLEYYVDIVNVLDNLLKEDWLGYREQLHCIQTAFAILGGQGEALNLDPLRFYNNLYKELLTINASSKKSDSTLILIKTLNEALVRRRKKITSKRMLGFTKRLAQLSLQLTHDGSMGCLSLIKTIMQLSRSTDILLDLDPSTGEGKYDPEIDDPEYSNASSSALYELMLLSKHYHPIVSKFGRNIASGAPSAGEGSLPGEYAKSAADQLYIDFDMSEMAFNPPVPPPKKEQPKTRPKQIFFADSTFEEECRQCLRRPTKRKSFWFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLD9</accession>
    <name>A0ABM5KLD9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Proton channel OtopLc-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511011.1">
        <property type="nucleotide sequence ID" value="XM_050655054.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655054.1">
        <property type="protein sequence ID" value="XP_050511011.1"/>
        <property type="gene ID" value="LOC126887486"/>
    </dbReference>
    <dbReference type="GeneID" id="126887486"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF58">
        <property type="entry name" value="AGAP000074-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="89511" checksum="608E115B300E1EA3" modified="2025-10-08" version="1">MPENVTLPENSERDEFNLNNPPTNNAASERPEKIFTIEDISDSEGTPSIRTVPIRIKGDDLSLASSEDILERSKNNIRVRHAISTNDVPSAYFLPRRINSTSDFRNYKYQKSEPKKSDKMVLKLVVPGNSRSASPIPSFHNNQYYSACSIEQMLGNGHFKERLKPPRLNVVNPDTNGAYINRGYSASDLAGSPLTPRTPSAFIPDNPTPHEEKKRTFSGILVTTFSIFYALFNVTVGLALYVTDTLDPSNPTAEIFSVYLVIVSFLYISFLIIDISIFSSKKKKYENAVEKNLCGENLKATQTEDGEFEFEINLPELLKGGKSVQHSYCFKKDRHSTNFYLKIGAAAFCFGHLIHAGILVGYQLVFITEDSAMFYECGSIPTLLLDLLYPIYSFFVLFFIFKYSNIVINKYTVLARFGMMHLLSSSICFWIWTIMRETLEAIASKKITAVTEEMDSEETTSKLSEPFALPLSSFALNGLELLRQSPDFSLRRFTKICVDNDSFMAVIYKNISPYLYPFSVEFSILVVGVLFVIWQNIEQCEDAENEDLSTLPCSILSELPLPDKEGNVVIHADCHSSNKGLFGGFVVLVLTVVSSILFFIAVYDEDKDAVIGLTINLVTSIAILSVMFLACIFAYRQITKLDFNTASHNVLDIVLLFVCIPAFFLNGVFSIIPAIINKNAMSTVSIILEILQVLVQTAFLQDGVRRSSNTKELRKTKPGRELVSFLILANISLWILQTFEVKAHGLQDNRYDFYGKELWTILGHMCLPLMMFYRFHASVCFVDVWKYAYVPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLP5</accession>
    <name>A0ABM5KLP5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511119.1">
        <property type="nucleotide sequence ID" value="XM_050655162.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655162.1">
        <property type="protein sequence ID" value="XP_050511119.1"/>
        <property type="gene ID" value="LOC114325384"/>
    </dbReference>
    <dbReference type="GeneID" id="114325384"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08389">
        <property type="entry name" value="C2A_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08408">
        <property type="entry name" value="C2B_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF2">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="318"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="474"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="615" mass="68449" checksum="DCA7344A873F32C8" modified="2025-10-08" version="1">MAQYGITIFIIRHRLAITLFLNTESNINNLTYIHTTTRSPTEDGRLLNERPPTKQFFNAGPLRDRLQLNKSQSQPNWLNNLVHGGTMLGAMAGLGAILLVFVLYVRNKGLIWWTPIRGMACCEEACPPISTRPIPTPSVPNFISNASPKTKLAKAYSFDGGESSSESEMGHANKTQLGHSPISVPVEPSSLPFYPTKPNHDLISLVEKGRVGMSSNSSCCSSTTSSVGEKHKVLSTKVTAEINNSIQKTPINLRETKIDNHSLEIQMVNTSAQIDTVDNNTTRDCIVVMAPDVEDRGEVMSYGEGSGSEPDCQVVPSKCGHLEIALLYDAPMRKMTVHVLQARDFPSRDRGQLTNTQVRLILLPSKKQKHKTKIRQGDNPQYMENFVLHRVNPEDVNSMGLRLRLYGCERMRRERLIGEAIVSFANINLELENNFWLNLEPKANTTMLGGCAADLLSLARSDSTGSAHSMQHGGVPELLLGLCYNATTGRLNVEVIKGSHFRNLAINRPPDTYVKLYLVSSTGQELAQSKTSVRRGQPNPLFKETFIFQVALFQLADVTLMVSVYNRKGVTKKKEMLGWFSLGLNSSGAEELAHWMDMKEFQQEQISRWHILVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLW8</accession>
    <name>A0ABM5KLW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511194.1">
        <property type="nucleotide sequence ID" value="XM_050655237.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655237.1">
        <property type="protein sequence ID" value="XP_050511194.1"/>
        <property type="gene ID" value="LOC126887631"/>
    </dbReference>
    <dbReference type="GeneID" id="126887631"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="367" mass="42909" checksum="5C583FA5B43A693B" modified="2025-10-08" version="1">MKFVGNEPRAKRSWTGIIRCCLNVLWCFGALYLGVLTFFLEKDLTFLKITGSIDNIILFSHTALKIASSGLQQPMMFGLLERRRLYFWDIGNSNVEENKKYRKKVLRYASFVNWFFLIATIFACSSFVLQPLVFRRKVLGFNTYVPESISYYAMAVYQFYIMLLALTGVLPFDLCVTYILCLISIQWKSLNTEIKNILDDEIVTLEDQKLFKTKVRRCVEHHNFLKRYIEDYNKSISLGLLAYLLMFVMSNCLNLFIVSSGPEVRELVKCILYQFNLANQFILTYVIPAQFLSTETQKTDEIIFDTKWYSTASKDKKLFVWMISSVAKKEVALNAGKIVTINYQFSLKIYRTVCSYYMFLRTLGRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMG2</accession>
    <name>A0ABM5KMG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050511391.1">
        <property type="nucleotide sequence ID" value="XM_050655434.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655434.1">
        <property type="protein sequence ID" value="XP_050511391.1"/>
        <property type="gene ID" value="LOC114327694"/>
    </dbReference>
    <dbReference type="GeneID" id="114327694"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="112"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="802" mass="88737" checksum="4B8828AFDFCE2496" modified="2025-10-08" version="1">MPASTVDPVNAALRTALSKNESTENLDIQLAGSSKKALLSNIEFESAGSYHNTVLDRLKSKYIVLRSPESPPPSKPEDDMNSSESLKLAKYELFPLSDVQLGWNNCDWSVGAGMVNMGNTCYLNSTLQALFHVPAFVNWLMSDKDHTAICQDSGGLCIICAMRKTLQDSQQRNANSIRPLLIYNKLRLVCRNLIPGRQEDAHEFLRYLVEAMEKAFLSRFNNYTEFDSKVKETTPLNQILGGYLRSAVRCLKCGHVSTTFQHFQDLLLDIRKAQTLDEALELYFSREKLDDESYQCESCQKKVPATKQFSIERTPMVLCIQLKRFSVSNNKITKHINFRQRLDLTKYARHRPNVPLIYRLVALVTHMGPTVSCGHYTAVAQAPSGNFFQFDDSMVRPISHQAVFNTNAYIMLYELESSPYSPKSAPATVTSKLKTSTPTAETSSVACSSNSSTVNSVTASTKSYANGIGFTSGKVYGPELPPDRIENSRNGYVTSSNGKGESDSSTSSSSEDSDADQVIEKSTVSDNSSNNSKTIKSGVSKDKDNDISSTCDEPGPSSASSQRKESPPSSPNVSTSISSLSSPEVTPKKDSSLSPVSSSKQKSKESPSKSQISKPLVPYESDDTSSSEDSNQSPHEMGSRVSTKAAVGEWQVTSSTDVDQEPSKGNGWKSKKENGQGNNQGNSKVVTELFRMSHSGYSAPVSSWNGSRSQLDKEVQNERREDRKRGLPDSSDQGRTKHVKLGSTFKSNPGYNPVQEYHNVKNWNNHNNGGGGGGNYKSFYNGNRHRRMFHHKNFHKNYRYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMJ0</accession>
    <name>A0ABM5KMJ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050511367.1">
        <property type="nucleotide sequence ID" value="XM_050655410.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511407.1">
        <property type="nucleotide sequence ID" value="XM_050655450.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655410.1">
        <property type="protein sequence ID" value="XP_050511367.1"/>
        <property type="gene ID" value="LOC114324950"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655450.1">
        <property type="protein sequence ID" value="XP_050511407.1"/>
        <property type="gene ID" value="LOC114324950"/>
    </dbReference>
    <dbReference type="GeneID" id="114324950"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF61">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="364"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="501" mass="57353" checksum="A8F1F5D56161D8CC" modified="2025-10-08" version="1">MTPDVPDRIAEVFKGSTIFLTGATGLVGKALIEKILKLCDVNKIYLLIRDKKGKTPNERIKDIFSNPLYQTVLARKPDCQKKCIPIPGDVSLVNLGISDENRKMLMDEVDFIIHSAATVRFDDSLKYAVTVNTRGTKFMLDLAEGCSKLKLFIHVSTAYAFPNNKDGITFEKEYPPPANPHEVLSSINWLKEDDLTDALTKKLLGDIPNTYTFSKALSESLVYEKAKKLPIIICRPAIVIPAFKDPIPGWTNNLQGPAGIFVGAGKGVIRTVYMNCDSYANFAPIDCTVSAIMMYAWHYLTTKDPQYIYNLCMPQSDLQVTWVEVLDTARDVIYNEVPFNLMLWYPDGSITQSRLYNKINTVLFQLLPALIIDLILLIAGQKPQFLAIQNRILKGIEMYEFYITKKWNFETTSLEQIRTGLNATEKENYQVQSDEKDVRKFLRDCMFYLRRHFFKETDDMLPAARRNMKILYCLDRFVKALVIGFIVYYLYKTFFLRSLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ31</accession>
    <name>A0ABM5KQ31_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512292.1">
        <property type="nucleotide sequence ID" value="XM_050656335.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656335.1">
        <property type="protein sequence ID" value="XP_050512292.1"/>
        <property type="gene ID" value="LOC114325742"/>
    </dbReference>
    <dbReference type="GeneID" id="114325742"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046568521" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="139" mass="15391" checksum="D29968C2DBC9D730" modified="2025-10-08" version="1">MYFLCFVICILFGNAVSRDLNDCPDTSRAVEVVFDKEVSTFVVGSQVCVRIPDDGLLQNPITCISVTDNRRSDNTPEVQAGGVGYPYAVVSVYPRMTELLSYRVVAFVDPRYDVVKEDKVNGLSETCLDSTNLHSPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRU9</accession>
    <name>A0ABM5KRU9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512914.1">
        <property type="nucleotide sequence ID" value="XM_050656957.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656957.1">
        <property type="protein sequence ID" value="XP_050512914.1"/>
        <property type="gene ID" value="LOC126888602"/>
    </dbReference>
    <dbReference type="GeneID" id="126888602"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="651" mass="74940" checksum="865A9AB320960BDF" modified="2025-10-08" version="1">MSTNKHSSEQTGVSEDDHRRDTDNGTDMENENRKKQSPDDLKWEEGMNSFEKELINSHKKKQKMNRSTAPKQSTLVGDEMLESSENDDDEIGEERSQEEVEKIEKGWQNIQERVLASFLLDDETMNKKKRKGDSLERINDLKRERLEESIKFPNETKQQKINRKLEELNTKLIEIFTNLSEKKGENVEMDTELKKLLGVIKSTNNKKEDDSIAEKTQQEVKCDHCKLKVEQERQREEQEKIKRALNMGGGKKTFMSICNSKWEEKAYIKTNWEQGGLRETVEKKICLIVTKKDAKDKGVENIIKDVGEDLAETLEEVNEGEIKFLENFRRKENKKTIWYTFVAGIEKESGGDIYDLAEKAITKIKKEMDETPKVVRVVAGNDLNKEIIRKALEYVGRRESISWEMIVRGKELEVEKKSEQEEALLIKMGGKKYNEVLSEMREKIDIGKIGLQVEKLKRTNGGDLLVKLKGRGAAEKLRAELDSKMNGMDTAIRRKETFFTITRLDPGVGEETLKKMIKSYTGVPEREIEVKVLRTNRYGEQVATIAVRPSIAEELRRYGSIKIGWVVCPIMERHNPVRCFKCLKFGHNTYECKEESRAACCYNCLQTGHTVASCGNKPYCSVCKEEGHRMDRMACPSYRALVYGRGGEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSF5</accession>
    <name>A0ABM5KSF5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513116.1">
        <property type="nucleotide sequence ID" value="XM_050657159.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657159.1">
        <property type="protein sequence ID" value="XP_050513116.1"/>
        <property type="gene ID" value="LOC126888787"/>
    </dbReference>
    <dbReference type="GeneID" id="126888787"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="534" mass="61514" checksum="1481BDC46193F391" modified="2025-10-08" version="1">MRAHRERLRQKQEIESLKNENRKLRSRALKEKIAAQYRSPNDKTNTEECPLPDLTPNTKINVTLEKAGVVVPNSIKKKLVFGECLKQHLNANFKSIKGHRSKQVFSEVVGGGILKKYGVTCKLNMSQYLSTSLPSRKKKRADVKINSVKRDVIQFFENDDNSRLRAGKKECITYKKVKKQKRYLNYSLKSLHQKYLKEKGCKISYTTFCRLRPFWVVVPRLGSQDTCLCITHENFRLIVSRLHFEKIINLKTPEEVISAVTCTPHNEECLSRQCKTCKEIQVPVNEFNANSQCQYQKWCTKKESRVSSKTGKTIIVQITLKEDITISHYNLVQEVFLLLPKYMLHVRNIYHQHRTLSTIKKSLNESKLLLHIDFSENYSCKYSSEAQSVHFGASRQQITLHTGVAYSKDRVSSFCTISPSLRHDAKAIAAHLIPILERFSTPLINTIYFLSDSPSTQYRNRTMFNIIGYYLPTKFRNINKISWSYSEAGHGKGAPDGIGATLKRTAYRLVAENTDIPCYEKFVNVVKKNVSNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSM7</accession>
    <name>A0ABM5KSM7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513197.1">
        <property type="nucleotide sequence ID" value="XM_050657240.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657240.1">
        <property type="protein sequence ID" value="XP_050513197.1"/>
        <property type="gene ID" value="LOC114328724"/>
    </dbReference>
    <dbReference type="GeneID" id="114328724"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06707">
        <property type="entry name" value="PDZ_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF1">
        <property type="entry name" value="GH21964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="314" mass="34746" checksum="EFA8D5B3A65DAA5C" modified="2025-10-08" version="1">MFKKQKKPSKLNSVQSDKRIDPVPRPPVSPVSPVTRSTLQFYCQLAHGSPTAFVSGFSNIKELYERIGECFNLPASDILFCTLNTYKIDMTKLLGGQIGLEDFIFAHCRGRPKEVELTKSESALGLTITDNGAGFAFIKRIKENSIIQNIPHIKVGDHVEKLDGVNMVGKRHFDVAKALKDIPVDTTFVIRLVEPVESGFSSIAPKSNKPSGGKKGYGSGKETLRFKADGKAEIQEQDDTMDIGIEKINGILETFLGINDSELAAQIWDLSVDKQNSMDFAEAIDDSELASFMFTDEIVIELWGVITDARDKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVG6</accession>
    <name>A0ABM5KVG6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA delta isomerase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514187.1">
        <property type="nucleotide sequence ID" value="XM_050658230.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658230.1">
        <property type="protein sequence ID" value="XP_050514187.1"/>
        <property type="gene ID" value="LOC126889700"/>
    </dbReference>
    <dbReference type="GeneID" id="126889700"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27768" checksum="05F91456AFB5AE7F" modified="2025-10-08" version="1">MALILESFRGGVKTITINRPKKKNALNRDMYLRIGEILNEDAKNDEIVVTILTGAGDYFTSGNDLSSISFNSGPDEAIKPVEDMVKAFINYPKLIICIVNGVAIGIGATIVALCDIVYASDKATFDTPFLKLGLCVEGTSSLNFPLILGRSLASEIFFLNRRLTAQEALHYGLVSRIIPHNDLNNYINDLHKYGKLAVGTVKRNKAAIMANFRQQFHECNKRELEVLKECVNSEDFAKSMAQWFASRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWW3</accession>
    <name>A0ABM5KWW3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050514683.1">
        <property type="nucleotide sequence ID" value="XM_050658726.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658726.1">
        <property type="protein sequence ID" value="XP_050514683.1"/>
        <property type="gene ID" value="LOC126889955"/>
    </dbReference>
    <dbReference type="GeneID" id="126889955"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="142"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="331"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="562" mass="64013" checksum="C4B8A358E7A658AB" modified="2025-10-08" version="1">MDAYDIFKKLTRGAKFSRNFNKEQIKKEKPVSSVVKHETPPAVKIEKVLTVSQDNPSITLISGLSTENRAKKRKFKDEEHILKGLEQEKINHYRNVNNITVVGRQVPEPCKSFQDFNVDSDIIDNLKKCGYEEPTPIQKQAVPLMLKERQILACAPTGSGKTAAFLVPIIHSLRGPQRQGFRALILCPTRELAQQTQRECDRLAEGRGFRVHVISKIKKALSQYNPSGSQKYDILVTTPNRLCFLLKQDPPAISLKNVEWLVIDEADKLFESGVRGFRDQLTEILKVCDNEKRKIAMFSATYTPVVAKWCVHNMKGLVRVTVGHRNAATELVDQELLFVGNEQGKLLAFRDLVRKGLSPPVLVFVQSKERAQHLFNELIYDGINVDAIHSDRTQLQRDNTVRSFREGRIWVLICTELMARGVDFKGVNLVINYDFPPSAISYVHRIGRAGRAGRRGKAITFFTVEDTVNLRSIAHILKESGCEVPPYMLTMKKISKTKRKQLEVSAPKRDEIITKPLYDRLSGGKRKKIREINSKLKEKLQLRKKKKPKKKQKANNNKDNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXL6</accession>
    <name>A0ABM5KXL6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514930.1">
        <property type="nucleotide sequence ID" value="XM_050658973.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658973.1">
        <property type="protein sequence ID" value="XP_050514930.1"/>
        <property type="gene ID" value="LOC114338529"/>
    </dbReference>
    <dbReference type="GeneID" id="114338529"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411067" evidence="3">
        <location>
            <begin position="18"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="858" mass="93174" checksum="F8871101F1872BC8" modified="2025-10-08" version="1">MVFKVVTLTLLVACAQAIRYDGHAATSSIVFNDNHNSVQHIQSAHPAPSHGYAAPIAHYSAPSPVSHYAAPAPVAQYAAPAPVAHYAAPAIKVAAPVLLKSSGPSHGASSYSSLSFGSDNGYYNQHSAPVAHYAAPAAKIAAPLLIKAPAKVAVAPVAYAQVAPAYNHGGYSHGGYSHHEEEYAHPKYEFAYGVEDHHTGDIHSHKEVRDGDVTHGEYSLHEADGTVRTVKYSVDKHSGFNAVVERSGHANHAQPTKVILKAVAPAPSYYHNPTNTVRNIIESCANTTLVAALTIYRFLSERKKQGITNLNTNEHLKRGKSLLKLMDLPKILFEGKFTDFFFKKEIPNLNKILQEVKDDPDLPNIGRTKLWEVLKELNFRWEKSDRKSVLIDREEIICWRRHYLRSIRKFRAEGRPIYYQDETWVNAGHTLTKIWSDKNILSSRQAFIEGWSTSISPPSGKDSRLIISHLGSEKGFLMDGLLEFQSKSTKDYHEEMTADVFEEYFEQMIEHIPPNSIIVLDNAPYHSRLVERLPTTAWKKQDVLDCLKNKSLTYEDGMIFIAVCAIASINCGAISYTSGGLHLDDDHGIGDYGHGISLVSHAVAAPIAYAKPVAIAKEVVDYSAPAHYEFKYGVEDAHTGDKKQQSEVRVGDSVKGEYSLAEPDGTVRVVKYTADPHNGFNAVVSRIGTEINMIAKVVLVCAFVAVAHGVGISVLDGGLGLGLGGHGLLGSGALVTGHSVAVAQPSVDLHAPANYQFKYGVQDAHTGDNKQQSEVRVGDTVRGEYSLAEPDGTIRVVKYTADPHNGFNAVVSRVGHAAHPQVVQRTVVAAPVISHAPVIAHAPVLGHGIGLDLGLGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYL7</accession>
    <name>A0ABM5KYL7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050515286.1">
        <property type="nucleotide sequence ID" value="XM_050659329.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659329.1">
        <property type="protein sequence ID" value="XP_050515286.1"/>
        <property type="gene ID" value="LOC114336588"/>
    </dbReference>
    <dbReference type="GeneID" id="114336588"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045665722" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="295" mass="33250" checksum="D597002AB65E7719" modified="2025-10-08" version="1">MSSMDALFVGGFKRLVLLIVLTYLHGSQGTRHVSVTIPIAAKTRDTVSLQCRYDLEGEPLYTLKWYKGAKEFYRYIPKELPSTQIFPLPGINVDTIKSNPNNLVLTNIQSEVTGRYKCEVSSDAPNFYTFMESGYMYVVDVPEDDPTMVLEKDLMEIGHVLKGNCTAPPSYPPANITWFLNGKKINESMKRTLPAAGQTKLTPSTSKRVPQVTFSGIEVEVDERSFYGGKARFMCEVTVFNLYKRQKEIEVEEDRPRPRPSSVLGNRDTSAGSTYRPATANFIICLLFVLQVCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0W2</accession>
    <name>A0ABM5L0W2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516077.1">
        <property type="nucleotide sequence ID" value="XM_050660120.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660120.1">
        <property type="protein sequence ID" value="XP_050516077.1"/>
        <property type="gene ID" value="LOC126890945"/>
    </dbReference>
    <dbReference type="GeneID" id="126890945"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="130576" checksum="4554D2635247A703" modified="2025-10-08" version="1">MGMLKVNTTFCGEFIKKAEEVENLERKYFNTKNEVIDVTTDLNYWFEVYVKNIVLTDLSEFEESQSGWALNQIISLEININKFEMAKGASSYIQLHPKVTKKRACINVKNNDQACFAWAIVSALYSVNINTNKTTSYPHYTTVLNLKGLTFPVTLNQISLFEKNNENISVNVFELNVKDELFNFSVLPVRLTKQKREKHVNLLIVQNKYYFNNEVDNVGPWSGERDEDLIHFHYIWIKDLGKLVNSQLSKHNGKKYICDRCLNYFYTKEKLDAHIIYCEKIDDCKISFTKEPYVKFKNFVYKEKLPFLVYADFESLLVPLRASHSTPSTTSTHPYQRHTAYSAGLYFKCNYDDNFSFYKSHVGLDCMSWFSHEIDNLAQFIHSKLINIQPMNVEVSLKDATERCHICNRKFLEKDRIVRDHCHLTGNFRGFAHNGCNLNYKKAFVVPIAFHNMSGYDSHFIIKDLAKMYDISILPVNKEKYISFTVYHKKTNIRFRFIDTFRFMGSSLDSLVSTLKPENFGILRKQFPNLDDETFKLLTKKGVFFYDYLDKIERLDETKLPNKEKFYNKLNDEHISDSNYAHAKLVWEKFNMKTLWDYSNLYMKTDILLLAVVFETFRDTCFKTYGLDPGHYYTIPGFTWDAMLKYTGCHLETIQDVDMLLFYERGIRGGISQCCNRMGEANNKYMMNYDPSKPSKYLMYLDVNNLYGWAMSEPLPYGGFHWDDTNIDVMSIPDDAKEGYILEVDLSYPENLHDYHKDLPFCVEHCKPPGSKQSKLLSTLYNKTNYVIHYRNLKQAISHGLVLTKIHKVLRFKQMTWLKGYIALNTQLRAQAKTSFEKNLYKLMNNAVFGKTMENQRKHRLVKLVNKWEGRVGARNLIASPKFHSRVIFDQSLMAVELKKAEIIFNKPLYVGMAILELSKTCIYEFHYDYMLQKFPLNQNKLLYIDTDGLIYETVCNDIYEEMIKPDIHRFDTSDYPPNNPWNIPLVNKKVPGLMKDENNSKIMTHFVGLRSKQYTYKVAGEKDVKKSKGVKMNVVKMKINFDDYLNCLKSFRETAETKSLFYATQRCIQSKLHEVYSIEQTKIALNPFDDKRHLLSNTFDTLPWGHYSITHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L257</accession>
    <name>A0ABM5L257_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516526.1">
        <property type="nucleotide sequence ID" value="XM_050660569.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660569.1">
        <property type="protein sequence ID" value="XP_050516526.1"/>
        <property type="gene ID" value="LOC126891390"/>
    </dbReference>
    <dbReference type="GeneID" id="126891390"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="785"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1242"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1375"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1507"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1553" mass="181189" checksum="725A26F8ED949ED2" modified="2025-10-08" version="1">METSSFPRHPVMDLFPRQYTKKIIGLILLNGYKNNEKIRITTQLDYLICDFTNENLFIEGLYHHRKKSSLSKTNLQHIFEIICGTSDVWKHIKSDISSFIFCINSSTTENDLNWLFLRNMRLSSDKNIRDNLFIESDEKSLFSQITGAKTYVFNKSHQEIISDLLLEFTAKNKWKIEKIFNMSENVVDMLKLCINRLKLIFFKEANLDITLMTLMKEVQIDQTDLPMYAYFLQQLEKFYDKEEIFVPEDVVQLKYQMHLDAVFTSVDEQMCSSAAHPSFKIEDSINFHLNLLKLFLLHGYQQQDDFRLSADNQLAGHFDDIVYETAQKSILLRAKYTAFGKTLPYNKIFPFDLYNKNFTIFKYLKSLTLIEEHFKNIESLSHCTNGRIDLRNINSNLKTEVLKNDYKLEVGQMEDCMIEIYLEQNHILNLFGTTKCYMFNPKYQHLLGELFLTGTDIDRQYVNIFLNKFQLYSIDLKHLEKQVQHLFKTIDILDSTIPQKISFSVFSDNLKKWWSKYTTKHSFLRPQHVLVYVTVNNGLEIMIRQIKGHVHFILSQQKRQNIIISLKNPFTYELHLLKVIQILASFGILHDEVLFIDHTKSIDIQAKMIRAFDLPEYSVLVITLFQFSYNHLKDTIIETIRNNNIPKEYKSIVFLTTDSYLHIKVKQDIEKYFDFDEINEEITFDSFSPITKKFILEKKIIFNGYDFCLQDVVGNDPNIWPTIFDEVMLHKIIFNDSIQMQYVLDEAKYENYDSKLYISRFLKIFNKVITEDDFLQNIALKTYSKVVLLVGDAGMGKTTFLSRLQYLLSTKPYWIFKINLWEFEYLFKAKAQDNVDHIQFEEFLTKVPWLKEDTFERRVFYLKNKVIVLLDGIDQIPPNYSNIYLHTLYHLTQQKNIANIIVGTRPYIVQSLLTVVTADICHLGPISKLDATMFIYKYWSNILELKENGEEDNTYKAYAEQLVKQMEIVIPSSTEIPLEVRMIAEYFLNMEDKDKISNLISTNIYKNNIDNKFGLNKTLDLETIENEHIKKSIKCIFDEVYHKLFKILDTPDIDKNVLYEFGIISEIEGLSYFCHRTYAEYFVAKHICDLLKEDELTTEMAEFIIKEIFLSSFSYNINLLIDSMLETKNIQEHVFEIFGRITENTQNSQILKIAEDRRDNILMLMLAKCRKCNGLYSYDEDTFTVTNKNENVLDYLINHSHHFENIDGHQNTILHLAILNNSKETVRSLVKKSDIINQKNNDGDTPLHLAVKKGYKDQVQLLIENGHPADDVNKDNETPLLVALRNKEEIIAKMLLPKTSNLNSVSELNKTALHLAVKWNLSSLVTELLDGGIKSEIADIEGNTALHEAVKNNNLEIAKILLKRYAFDINKPNHNGDSPLHLAVRSNRTELAEYLLANNADALRKNLLGNTPLHEAVDQNAELLIFSLYNRDEESIHINKNGDTPLHLAVKNKLQHVVEWLLDNNCAVQPQNFSGDTPLHIAVDNNYKDIIHLLTGRGGNVNIKNNKGNTPLHLAAKHNLKEIVKHLLEIKLNRKIVYNDQDKPRIMAIDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2D1</accession>
    <name>A0ABM5L2D1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516593.1">
        <property type="nucleotide sequence ID" value="XM_050660636.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660636.1">
        <property type="protein sequence ID" value="XP_050516593.1"/>
        <property type="gene ID" value="LOC126891459"/>
    </dbReference>
    <dbReference type="GeneID" id="126891459"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="211" mass="24524" checksum="6380DC0B6A6B06AA" modified="2025-10-08" version="1">MHCYFLPKTSTKSYADYHEDMTAHLFEKLFKEQLLPNIPPNSVIVMGNASYHSRLLTKIPNSSTKKDGIVTFLRDKNIPLPKRVPLKKDLLNIVKSHNFKKEYVLDEFCKTQGHTILRLPPYYCIFNPIEMIWGIIKSRLRKCNQSLKLSAVLLDKIRQVVNEFDSDIFKNCISHVIDKENEYPIMDRTIAPIFIQPNLDTDSSSDDYNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2D8</accession>
    <name>A0ABM5L2D8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516602.1">
        <property type="nucleotide sequence ID" value="XM_050660645.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660645.1">
        <property type="protein sequence ID" value="XP_050516602.1"/>
        <property type="gene ID" value="LOC126891467"/>
    </dbReference>
    <dbReference type="GeneID" id="126891467"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="171"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="323" mass="37660" checksum="FD31BBF1196384F3" modified="2025-10-08" version="1">MRVLRRTLHEMDFRYVKRSRKSLLIERAELVIWRRKYLQKIRDFRRLNKKNYYTDETWLNEGHTKSKVWQDLNIKSARQAFIEGLSTCLKAPSGKGRRLIITHIGSDSGFLQGGLNVFTSIKTSDYHEDMNSDVFEKWFSSILTLVDPGSVIVMDNAPYHSRRVEKIPTSASRKADIDWLRSKNIDFDESMIKVQLLDIVRKHKSSYIRFAVDEMAREHDITVLRTPPYHCELNPIELIWAKIKNEVAQKNTTYKLKDVKLLLDQAIQNITASNWQSCITHTQKEEDKMWDVDTRVDVLIEPIIITPGEDSSDSELTIGSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2G5</accession>
    <name>A0ABM5L2G5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516628.1">
        <property type="nucleotide sequence ID" value="XM_050660671.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660671.1">
        <property type="protein sequence ID" value="XP_050516628.1"/>
        <property type="gene ID" value="LOC126891494"/>
    </dbReference>
    <dbReference type="GeneID" id="126891494"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21953" checksum="8A8BF59359E7D520" modified="2025-10-08" version="1">MTSSLFKEWFEKKVLPNLPPKSVIVMNNATYHSEQIRKIPGVVSTNKYVIFCMTVICTLKKHIQKKKCWKFFIQKRLRKFVIEELAKRDGHNVLRLPPYGVFNPIELIWSQLKESLRRNNCCPKFSSQSVSHVVEEIKKISPTLWQNCVSHVIKTEGHYRTLTSHIKPIIITLGDDDSSEHDSDSGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2M2</accession>
    <name>A0ABM5L2M2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050516680.1">
        <property type="nucleotide sequence ID" value="XM_050660723.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660723.1">
        <property type="protein sequence ID" value="XP_050516680.1"/>
        <property type="gene ID" value="LOC126891547"/>
    </dbReference>
    <dbReference type="GeneID" id="126891547"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="230" mass="26306" checksum="80F72533C67FA407" modified="2025-10-08" version="1">MFSIYRTTVSRIFYSTLDNLAEATATLVFWPDKLSVRATMPDCFKPNYSNTRVIIDCTEFKIDVPSAVDHRVYCYSNYKKGFTLKVLIGITPSGFICFKSPAAGGRKSDSQITIESGLIDLLEEEDVVLADKGFPDIQTVIDSQGKKILLVMPPFLERKKEFSQEETEQTYTIARVRIHVERIMQRLKTYNILNKIPEYLFDNVDDIIHICCVLVNLQPPIFAEKSENNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L358</accession>
    <name>A0ABM5L358_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516876.1">
        <property type="nucleotide sequence ID" value="XM_050660919.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516877.1">
        <property type="nucleotide sequence ID" value="XM_050660920.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516878.1">
        <property type="nucleotide sequence ID" value="XM_050660921.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516879.1">
        <property type="nucleotide sequence ID" value="XM_050660922.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516880.1">
        <property type="nucleotide sequence ID" value="XM_050660923.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516881.1">
        <property type="nucleotide sequence ID" value="XM_050660924.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516882.1">
        <property type="nucleotide sequence ID" value="XM_050660925.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516883.1">
        <property type="nucleotide sequence ID" value="XM_050660926.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660919.1">
        <property type="protein sequence ID" value="XP_050516876.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660920.1">
        <property type="protein sequence ID" value="XP_050516877.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660921.1">
        <property type="protein sequence ID" value="XP_050516878.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660922.1">
        <property type="protein sequence ID" value="XP_050516879.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660923.1">
        <property type="protein sequence ID" value="XP_050516880.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660924.1">
        <property type="protein sequence ID" value="XP_050516881.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660925.1">
        <property type="protein sequence ID" value="XP_050516882.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660926.1">
        <property type="protein sequence ID" value="XP_050516883.1"/>
        <property type="gene ID" value="LOC126891680"/>
    </dbReference>
    <dbReference type="GeneID" id="126891680"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="482" mass="55900" checksum="8EF2BFA41EA3989D" modified="2025-10-08" version="1">MKIHKTDVFENIPIRPVVSFTDSPTHALASHLNKFLKTFYNNKFDYVVSNNLSLTNKITEVNLSNEDLLISLDITNLFTNIPTHEVISIVALDLWNNNYHPNQIIEYTELLNLCLSQNFFNFNNTTYVQPDGLAMGSPLSPILADIFLNDLESNKIVKNNPFTDYIKFYARYVDDTLIIWNGTIDILHDFLDFLNTLHDTIKFTLEIQNDSKSLNFLDLTLTLRNGTIDFGIYRKPTHTGTVIPADSHHPIQHKLAAFYSYINRLVSIPLTTTSFNKELKIIQQIAVNNGYTVDLVNKILHKKTNRILEHRVYTQPILVEQEPKPYRSLTFTGQFSYKLAHIFKDYCNISFRTNSNLGLVFLNNKDSRDRSECCGVYELKCHTCSSYYVGRTFRSFDTRLKEHLRYIQRPTSGQSHFSQHIRNSNHNFNPDIDFKILHICKKGHVLNNLEHFEILKSLKDPTRHTLNAQLELEFIPAYSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L413</accession>
    <name>A0ABM5L413_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aurora kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050517186.1">
        <property type="nucleotide sequence ID" value="XM_050661229.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661229.1">
        <property type="protein sequence ID" value="XP_050517186.1"/>
        <property type="gene ID" value="LOC126891889"/>
    </dbReference>
    <dbReference type="GeneID" id="126891889"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="75"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="333" mass="38202" checksum="0D1A069C14E3287E" modified="2025-10-08" version="1">MAHKPTLKEEHVVSNKENDPKTIVQGNTKHFDGQKHKKPMKENVQDKDTKVENNGKQNSDGATRQEKQKWTLGDFDIGKPLGKGKFGNVYLAREKRSKFLVALKVLFKSAIKEFNNEHQVRREIEIQSHLRHPNILIMYGYFHDETRVYLILEYAPNGALYSKLSASPNKRFSEADSAAYIEQIADALRYCHTKKVIHRDIKPENLLLGAKGEIKIADFGWSVHAPSSRRSTLCGTLDYLSPEMVTGKTHNEKVDLWSLGVLCYEFLTGRPPFESKSYDDTYRRISRAQFTIPPYVSAEAGDLIKKLLVVKPELRLELGHVLNHPWILKYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L443</accession>
    <name>A0ABM5L443_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein heavy chain 1, axonemal-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517200.1">
        <property type="nucleotide sequence ID" value="XM_050661243.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661243.1">
        <property type="protein sequence ID" value="XP_050517200.1"/>
        <property type="gene ID" value="LOC114339168"/>
    </dbReference>
    <dbReference type="GeneID" id="114339168"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="5">
        <location>
            <begin position="94"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="4">
        <location>
            <begin position="369"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="6">
        <location>
            <begin position="743"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="3">
        <location>
            <begin position="1207"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="7">
        <location>
            <begin position="1357"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="8">
        <location>
            <begin position="1502"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="595"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1803" mass="206054" checksum="A083A4B7CADA4811" modified="2025-10-08" version="1">MLRLWYHENCRIFQDRLINDEDRNWFDALLKSEIERRYRLKSEEVLGTTDILFGDFIDPSVGVGPYVQITDFEKLSDALNYYLEDYNLQSTKPMKLVLFLDAMIHISRISRIIRQPLGNALLLGMGGSGRQSLTRLAAFMSEYSCFQIELTKAYGQNEWRDNVKHLMLSAGLQRRETVFLFSDTQIKSESFLEDLNNILNSGDVPNIYQPDELDKIYQSMKGLVQEMGLTATKSNLFAVYQKQVRTNLHNVITMSPIGEVFRARLRQFPALVNNCTIDWFSPWPDTALQSVALRFLKEVEDFDVSESILQGIVMTFQYMHASVVEASERFKQELSRHNYVTPTSYLELLSSYTELMNKKKGSLTEGVGRLKTGLGKLQTTAEEVKILQSQLKELKPLLEEAARDADIMITKIAADTVIAEETKEIVEKEEQAAAEKAYETQNIAEDAQRDLDEALPALLAAEASLKALNKNDIIEVRSMKRPPAGVVYVIEAICIVKNIKPNKIPGFKPGEKLLDYWDPGRVMLADPQAFLMSLMNFDKDSITEEMIDKLRKYVEDPLFTPQKISKVSKACTSLCMWIHAMFKFYFVNKAVAPKKAALARAKADLEATLQALADAKAKMKEVLEGLEQLQKALAEKIAFKEEKEQSIAVCEEKLNRAMRLINGLAEEKIRWEQTIEEIDANVVNVTGDILICSGCVAYLTPFTDSYRRSLFASWMEKITYYQIPFTPNCNPVTILGEPVQIRLWQLDGLPRDYLSTENAVLVSCSRRWPLFIDPQGQANKWVKKMCKNMGLSVCKLADRDLMRTMESSIRFGKAVLIENVGIELDPALDPVLLHQVFMQSGTLVIKLGDVVVPYDDNFRLYITTKLPNPHYTPEISIKVLLVNFTVVSTGLQDQLLALVVMQERPDLEEQRSQIVVSIATMKHELKEIQDRILYKLSSSELSPIEDLDFIITLEASKVKSEDIKSKVESAEITQIDIDNTRALYIPVANRAQILFFCVADLSNVDPMYQYSLEWFIQIFVSTMADTEKSDNIIQRVKTINDSFTFNLYCNICRSLFEKHKMHFAFLLCIRILMDLKKIDPQEWQHFLAGGTPKQRMPNPASSWLSSRAWNEILALDALPTFQEFVQTFASNIDDYRIMFESSEPHRFPLPYPFNKTFDKFQKIVVLKSLRPDKVTNAIQDFLAENLGQQFIEPQTSDLSAMFKESGPTIPLIFVLSTGTDPAAELYKFADRMKMGKRMFSISLGQGQGPRAEKMMQGGVEVGSWVFFQNCHLAPSWMPRLERVIESLTPETTHRDFRIWLTSTPSPHFPVSILQNGSKMTIEPPAGLKANMMRAYRNEVSELTSFIQSDNPKSPTFRLLVFSLCLFHGILLERRKFGPLGFNIPYEFTDGDLKICISQLHMFLLEYTEIPFKVLTYTAGEINYGGRVTDDWDRRCLMNILADFYKKEVIVPNYVFDHQGFYHQIRTDVLFVDYIDYIKTLPINDDPELFGMHPNADITFAQSQTYACLSTLLLLQPKQVGGAAASQEETTANTARSILDQLPELFDLDKITERYPVLYEESLNTVIIQEAIRYNKLLVVIQLSLNDLLKALKGLVVMSEALEKMSLSLFSNMVPDLWASKAYPSLKPLGAWVGDLKARIEFLNRWKREGIPPVFWISGFYFPQAFLTGTLQNYARKYVVSIDTINFAFEILEHFPKKRPKDGCCIYGLYLEGARWNPNIDHLDESNPKELYTDMPVVWLKPEEHHELPSHVYQCPVYKTLTRAGVLSTTGHSTNYVLTIEIPSRKPQSHWIKRGVALICALDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L539</accession>
    <name>A0ABM5L539_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517552.1">
        <property type="nucleotide sequence ID" value="XM_050661595.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661595.1">
        <property type="protein sequence ID" value="XP_050517552.1"/>
        <property type="gene ID" value="LOC126892121"/>
    </dbReference>
    <dbReference type="GeneID" id="126892121"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="143" mass="16114" checksum="08878107C51432E6" modified="2025-10-08" version="1">MASCAFPLCTNNKRKNQKNSTGITFHSFPKDVEKRKAWVQFVHRENWEPATSSKLCTKHFAERDVDRTSLVCIRLRENAVPTIGESQFLEKNQYFSLREPPASYITGDATSRQKGTGCILQTAAPNISSCSDLRPQHLPTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5S9</accession>
    <name>A0ABM5L5S9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517794.1">
        <property type="nucleotide sequence ID" value="XM_050661837.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661837.1">
        <property type="protein sequence ID" value="XP_050517794.1"/>
        <property type="gene ID" value="LOC126892330"/>
    </dbReference>
    <dbReference type="GeneID" id="126892330"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="269" mass="31866" checksum="F0117BCA9B55664B" modified="2025-10-08" version="1">MSEAPTSPSKDHQLKDVANTSKDYQLKYVPWVFKSSSQFTPYYTRVTQSSLGKYCVPVISKDDELPKRGPSVIHPKILENMMFDERYSWLARPGKEDFFIHEMYRKFTPDRSKGMYDPRYMHKEKIFNRSYQFELDCIEAERLEKRRVKNETDAAEFEGSFQRLVKKQVEKESPPIPLVPCKIEPPIWWPKTPQPDEEIIEPVKVTPVYTRSHARWIEEPNLTAFVQDNLCQRKKDMLLVGQPFKTEACNWYYKIYPPPDIKFVPKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7W6</accession>
    <name>A0ABM5L7W6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050518533.1">
        <property type="nucleotide sequence ID" value="XM_050662576.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662576.1">
        <property type="protein sequence ID" value="XP_050518533.1"/>
        <property type="gene ID" value="LOC114328496"/>
    </dbReference>
    <dbReference type="GeneID" id="114328496"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25325" checksum="C50D41E3A5BE4694" modified="2025-10-08" version="1">MDLVTHDSKHIEYNPDCPLARGFVFQIWYPFMVEDYPWICSLFDVVTVFIGMILFCYYKIIPMSLILFLLGQITLLKHDIRQLNIENISNVCGLKKSGENKLKDCVKSHQLIIRLMNWIQHSLKEIILIQYVSYVLDTAAFMIPTLTSKSIADVIYNSVMWVDANESDKKVLLLMMLRSQQKLALKSTALGEMSLICFTKIMKLCYTVCTFFTTMYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8U7</accession>
    <name>A0ABM5L8U7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518863.1">
        <property type="nucleotide sequence ID" value="XM_050662906.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662906.1">
        <property type="protein sequence ID" value="XP_050518863.1"/>
        <property type="gene ID" value="LOC126892961"/>
    </dbReference>
    <dbReference type="GeneID" id="126892961"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="137" mass="15617" checksum="03A5259591EB0117" modified="2025-10-08" version="1">MALSCKVIVAAVFVVFFCVITECTTLNGLWVEHKDNNSKMLCGDPQPRAVYGKEIFSKDLWNKEYKKYKKWIPKMNPPYTILHRCEGSGGCSEDNKDKNNKRRCQVNGMNTVWKVFRFGNGTLESLPVVNHTSCMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAM9</accession>
    <name>A0ABM5LAM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519495.1">
        <property type="nucleotide sequence ID" value="XM_050663538.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663538.1">
        <property type="protein sequence ID" value="XP_050519495.1"/>
        <property type="gene ID" value="LOC126893398"/>
    </dbReference>
    <dbReference type="GeneID" id="126893398"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047474655" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="4">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="473" mass="51410" checksum="32E27F2F1FFB235F" modified="2025-10-08" version="1">MIRVYLLCCAVVLARAQIPSLGFCPDYLPMSEFDIESFLGKWYEAERYFQFTEVTSRCVVTDYAKGPSGKIYVSNEVTSRLTGIKRVIDGQLELSGRSGEGKFNIRYSTPLSSQAQLTVLDTDYDNYAVIWSCSGFGPIHTQSVWAMTRERLPSGPVLQKIYGVLDKYKISRNFFVKTDQEGCALAASDINAANGITVISTVAESSGIPQRKSPSSNKKKVTEKVPSVQAVKVSDNDVNDDPNVQAVKSIEIDLKAPEDILPEPFASNVNIPEVATAEEVLPEAFVPKDIIPDPVSADEILPEVFVPKAIIPEQVLPEVVIRESVGSQGILSESVVPKIPAAAQINSGVIKSIPFISEQINIVETPVANVANDAVQAIVKSIEAPIQQDVVKAEDQLKPLEVAEVIIQNSPVEPVDIKENLLKAQLVPVLQPVAIFASEDGQVPQAVEVIGESIAPVKMELDEKIVLLDSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAS1</accession>
    <name>A0ABM5LAS1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-xylose and UDP-N-acetylglucosamine transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519536.1">
        <property type="nucleotide sequence ID" value="XM_050663579.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663579.1">
        <property type="protein sequence ID" value="XP_050519536.1"/>
        <property type="gene ID" value="LOC126893418"/>
    </dbReference>
    <dbReference type="GeneID" id="126893418"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39826" checksum="BAEC69ECEA26CB54" modified="2025-10-08" version="1">MCIKKCIKVLLNNEMSAKAAQAIVLTLTGCMLNNVFLEYIIKLDPGAGHLITLCQFLFIAVHGLIFTSKFGTVKPKIPLSGYMTLVVLFFTTSVVNNWAFAFNIPVPLHMIFRAGSLIANMIMGIIVLKKKYTLEKYISVLLITLGIIICTIYSSSEKPKVCADCELGVETHSDAVADHFFWWIIGIILLTGALLLSAGMGIFQEGLYKKYDKHPEEALFYTHLYPLPGFLIYSSSLIEHIGIANKSDLINIPIVNFAVPVLWALLFLNVVTQFVCISNVYVLTSECASLTVTLVITLRKFFSLVFSIIYFQNPFTIVHWIGTIMVFAGTLMFSETHHKIKNLMVSSDQDKTKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EXE0</accession>
    <name>A0A6P7EXE0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114324240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114324240</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127829.1">
        <property type="nucleotide sequence ID" value="XM_028272028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EXE0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272028.1">
        <property type="protein sequence ID" value="XP_028127829.1"/>
        <property type="gene ID" value="LOC114324240"/>
    </dbReference>
    <dbReference type="GeneID" id="114324240"/>
    <dbReference type="KEGG" id="dvv:114324240"/>
    <dbReference type="InParanoid" id="A0A6P7EXE0"/>
    <dbReference type="OrthoDB" id="6330326at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647:SF4">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="8">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028127829.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15161" checksum="7FE8D3E63560D7BD" modified="2020-12-02" version="1">MHLQSTLIFILINFYCFTCSPYYVNNLSKRSQKTCGHRLTDRLNRICLGRYWSPNSNNKRSTDNDVMNMDNDFLDTIDSDYSNTDVIYPYVSTDPVFSLLLPKKIQKSFGIVNECCYNACTDDTIGEYCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYD2</accession>
    <name>A0A6P7EYD2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc transporter 7-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114324374</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127991.1">
        <property type="nucleotide sequence ID" value="XM_028272190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EYD2"/>
    <dbReference type="FunCoup" id="A0A6P7EYD2">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272190.2">
        <property type="protein sequence ID" value="XP_028127991.1"/>
        <property type="gene ID" value="LOC114324374"/>
    </dbReference>
    <dbReference type="GeneID" id="114324374"/>
    <dbReference type="KEGG" id="dvv:114324374"/>
    <dbReference type="CTD" id="41342"/>
    <dbReference type="InParanoid" id="A0A6P7EYD2"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="39"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028127991.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38778" checksum="7172DE045D6812FF" modified="2020-12-02" version="1">MLPLSHKDKAYPRGFGSRIKEKVNGWIRLIFSDRNSRNLFLFLILNLSFAFVELIYGVWSNSLGLISDAFHMFFDCTGLLAGLAASVITKWKANDRYSYGYVRAEIIAGFVNGLFLLFISFFLMSEAVERAIEPPEVKHERLFVVSVLGLLVNLVGIYAFQHGHGHSHGGSHGHSHGRSNHGHSHSVNNHHHSHDIEFDSGNSQIMKGVFLHILADTLGSVGVIISAVLMSLFGWMIADPICSMFIAILIALSVLALIKDSVMILMQRQPAALDNVLPQCYQKVVSLAGVYSVQEPHFWTLCSEVYVGTIKLEVSKTVDPKYVVSHTQMIFASVGVRQLYVQLDYTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2E8</accession>
    <name>A0A6P7F2E8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein DP71L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">MyD116 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114324429</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts (via C-terminus) with host PPP1CB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R15 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the asfivirus DP71L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128078.1">
        <property type="nucleotide sequence ID" value="XM_028272277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2E8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272277.2">
        <property type="protein sequence ID" value="XP_028128078.1"/>
        <property type="gene ID" value="LOC114324429"/>
    </dbReference>
    <dbReference type="GeneID" id="114324429"/>
    <dbReference type="KEGG" id="dvv:114324429"/>
    <dbReference type="CTD" id="37820"/>
    <dbReference type="InParanoid" id="A0A6P7F2E8"/>
    <dbReference type="OrthoDB" id="5976067at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051254">
        <property type="entry name" value="PPP1R15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019523">
        <property type="entry name" value="Prot_Pase1_reg-su15A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489:SF12">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10488">
        <property type="entry name" value="PP1c_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="8" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="10" id="KW-0922">Interferon antiviral system evasion</keyword>
    <keyword evidence="9" id="KW-0426">Late protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 15A/B C-terminal" evidence="14">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028128078.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40391" checksum="21B5C4D25C52E59A" modified="2020-12-02" version="1">MWNCTRSFSPGGPVIGPLLQPQKRDFSYSMSNLSVAPKKLFSNQNFVSNHYPKVQNHFNNTAYSPYHMCHNPGDTIEIKVKSAENSSQNNIDIIQESLPVEKSPVQDSQMCSTRKRCKKNRRNRKKVTNKSSKQNKSRRQITDMMEVDVEPDVSMDNADYSMSSNFPSSSPTCISVADFLLDIPAKTSKSDDDVFTLISISPSISSRPCSREREISICESEDSFIVFDSGTDEELKFSDSEDNAELDSEDTDDEDDVVDGGSDSESDDDCDSSFSVVPCKRVRFADNEDLCEIHQMVQWSFAYRKARKGPWEEYARDRERFNKRISETERILAPIFDGRHRENVYKSRFEDTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2Z4</accession>
    <name>A0A6P7F2Z4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324283</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127885.1">
        <property type="nucleotide sequence ID" value="XM_028272084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2Z4"/>
    <dbReference type="FunCoup" id="A0A6P7F2Z4">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272084.2">
        <property type="protein sequence ID" value="XP_028127885.1"/>
        <property type="gene ID" value="LOC114324283"/>
    </dbReference>
    <dbReference type="GeneID" id="114324283"/>
    <dbReference type="KEGG" id="dvv:114324283"/>
    <dbReference type="CTD" id="51371"/>
    <dbReference type="InParanoid" id="A0A6P7F2Z4"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028127885.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15528" checksum="20CA194FBDDF5816" modified="2020-12-02" version="1">MSFALPSVKPRASAPENFDIHGDTFGAQELMKYGLQSAKCSTEVPHQLLGSESKYHANRQQMNMTILANTQGLHAPLRLAMELKSSKKIGRLPFLPSSNIMHDVLTGRDLDVGPEDVYGTSEFLEFSGQPHAVVEKYLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3M9</accession>
    <name>A0A6P7F3M9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SGT1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326205</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130284.1">
        <property type="nucleotide sequence ID" value="XM_028274483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3M9"/>
    <dbReference type="FunCoup" id="A0A6P7F3M9">
        <property type="interactions" value="1724"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274483.2">
        <property type="protein sequence ID" value="XP_028130284.1"/>
        <property type="gene ID" value="LOC114326205"/>
    </dbReference>
    <dbReference type="GeneID" id="114326205"/>
    <dbReference type="KEGG" id="dvv:114326205"/>
    <dbReference type="InParanoid" id="A0A6P7F3M9"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="13"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="126"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028130284.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24092" checksum="E181750383167695" modified="2020-12-02" version="1">MTEEQATMEGKPKLPVRHDWYQTDAAVVITVLVRNIKEEHLKLDIATNKVTIDISHPDFEPCNLCLNLSNSIIADQSSYKLSSAKIEIKLKKCEGLRWEKLEGAPKVEAIKVIPKEAEPTTDGPPSYPTSKKGKDWNKVEKEIKEQEAQEKPEGAEAINALFQEIYGKGSDEVKRAMNKSFMESSGTVLSTNWNEISKQKVEAKPPDGMEFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5Y4</accession>
    <name>A0A6P7F5Y4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F-box/WD repeat-containing protein 1A isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326685</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130896.1">
        <property type="nucleotide sequence ID" value="XM_028275095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5Y4"/>
    <dbReference type="FunCoup" id="A0A6P7F5Y4">
        <property type="interactions" value="1678"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275095.2">
        <property type="protein sequence ID" value="XP_028130896.1"/>
        <property type="gene ID" value="LOC114326685"/>
    </dbReference>
    <dbReference type="GeneID" id="114326685"/>
    <dbReference type="KEGG" id="dvv:114326685"/>
    <dbReference type="CTD" id="42504"/>
    <dbReference type="InParanoid" id="A0A6P7F5Y4"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130896.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="59506" checksum="8C4CB963FA277229" modified="2020-12-02" version="1">MIKMETDKIEESTTNNTQYPMTILPPYDTARKKEPSATFNTEREACLKYFEKWSETDQVEFVENLLARMCHYQHGHINSYLKPMLQRDFISLLPKKGLDHVAENILSYLDADSLRNARLVCKEWFRVISEGMLWKKLIERKVRTDSLWRGLAERRNWIQYLFKPRPGENHRPPDFYRALYPKIIRDIDSIESNWRNGKHILQRINCRSENSKGVYCLQYDDQKIVSGLRDNTIKIWDRSTLQCTKVLIGHTGSVLCLQYDDKVIISGSSDSTVRVWTVNTGEMVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSQSEITLRRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWNTSSCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRILEGHEELVRCIRFDSKRIVSGAYDGKIKVWDLLAALDPRAPTNSLCLRTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNSVPDPKPKTSEPKSPSPFNSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F947</accession>
    <name>A0A6P7F947_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC114326018</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028130005.1">
        <property type="nucleotide sequence ID" value="XM_028274204.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130006.1">
        <property type="nucleotide sequence ID" value="XM_028274205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F947"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274204.2">
        <property type="protein sequence ID" value="XP_028130005.1"/>
        <property type="gene ID" value="LOC114326018"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274205.2">
        <property type="protein sequence ID" value="XP_028130006.1"/>
        <property type="gene ID" value="LOC114326018"/>
    </dbReference>
    <dbReference type="GeneID" id="114326018"/>
    <dbReference type="KEGG" id="dvv:114326018"/>
    <dbReference type="OrthoDB" id="10009867at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000083">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="446"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028130005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028130006.1"/>
        </source>
    </evidence>
    <sequence length="786" mass="88599" checksum="DC4D1BBE790ED302" modified="2020-12-02" version="1">MPVLSPHRSSSSGLSGSYRSTFSSSALDRPFYSSTSYSPRFNTYSERYTSRSFTDSDGRRIYTRSGSITEDGVTTRFREESREPSLKRDSISRDSGISSIRENSISDYPRRESSLTRSDRLSHVNVIDSVAELRNKYSPANYVPACMRKNENLSRSKSNNDIGLPPLEVKSTKKKVNDRVDSIYTNSVAYSNNTNTDNLTDEDDNGNRTSVADLCKRFDDKLSRTVKNGTSLTNKTSEVKSKISELTNGVKPLSGKTKTANVKKSISNGSVAKKNDASSIKCQNNVDVLQSNSKLEVNEDSDLKNGTEVEREEVSEEGASNHSLSKNGSRVNNFSSYISISTKDFQRGDENQSDQKNDMDTKEYIGKVIQNTDLSTSPKVTRTAISPSNSIANSLNSNSLSRRSSERENHRIRDYSDDDSSGERVLNSYATIRSSECTPQKSLGLNGLKNIGNTCFMNSVLQCLSNTRWLLEYLKKDGYIKDINTSISSMKGALIKAFAEVIKELWSEDASDRVVNTASLKGQIQRFAPRFMGYAQQDAQEFLRYLLEGLHEDVNRVQEKPKPILTEIDEKLSDNEKAQESWTRYLRMDNSRIVDHFVGQLKSTLKCTHCGHCSVTFDPFWDLSLPIPQRTGQLRLSQCLDSFTREETLDGDEKPTCSKCKERRRCTKSFSIHKFPKILVIHLKRFSPTERFRGKLNVTVDFPMEGLDMSQYAADNVSPCRYNLYAISNHSGTTYSGHYTAYCRHPYTGHWHEYNDSRVSSISSKSLVSGEAYVLFYEQEGAKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F984</accession>
    <name>A0A6P7F984_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methanethiol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114327870</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132384.1">
        <property type="nucleotide sequence ID" value="XM_028276583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F984"/>
    <dbReference type="FunCoup" id="A0A6P7F984">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276583.1">
        <property type="protein sequence ID" value="XP_028132384.1"/>
        <property type="gene ID" value="LOC114327870"/>
    </dbReference>
    <dbReference type="GeneID" id="114327870"/>
    <dbReference type="KEGG" id="dvv:114327870"/>
    <dbReference type="InParanoid" id="A0A6P7F984"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028132384.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="53885" checksum="9CC1A41257EF9175" modified="2020-12-02" version="1">MANGSGPGYATPLDAMKNGPKEKLMYVVCINPNEGEDKTDLLATVDVDPESPTYCQIIHRLRTGHKNDELHHSGWNVCSSCHSSTGCCNGLVRDKLILPALGSDRIYVVDVGKNPKAPEFHKIIEGTEMRRFNCRTPHTAHCLASGEVMISTMGDNEGNAKCDFILLDGKTFEVKGTWLKGDKAPKYNYDFWYQPYFDTMVATEWGVPKVFKKGFQPSDTRPEIYGRSLNFFSWKKREFIQSINLGEDGIAPLEVRFLHNPKKPQGYVGCAVNANIFRFYRKDDGTWAAHKVIDVPQKKVSGWIGPYIQGMITDILISLDDKYLYFNNWLHGDVRQYDISDREHPKLTGQIFLGGRILSDSDLKVLEDQELKEQPKPVYIKGKRFQAGPQMMQLSLDGKRLYITSSVLSPWDKQFYPQVVENGTKMVKIDINHENGGMKLDENFLVDFGEGPDGPLLAHEPRYPGGDCTSDIWLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBR9</accession>
    <name>A0A6P7FBR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114328411</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133056.1">
        <property type="nucleotide sequence ID" value="XM_028277255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBR9"/>
    <dbReference type="FunCoup" id="A0A6P7FBR9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656680.1">
        <property type="protein sequence ID" value="XP_050512637.1"/>
        <property type="gene ID" value="LOC126888427"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FBR9"/>
    <dbReference type="OrthoDB" id="6743260at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028133056.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="44486" checksum="33ED773AD0077889" modified="2020-12-02" version="1">MILMWPDEKDHTILKLSCTVLIGASIFVFYGEFMYILKHVNEFDKLFYGLFMLVVPVLTISKLPVVAYKCKELKHLLDMISANFWPSDMLDKTNNNSFNGLYKAGYVFMIIMFTTGQIFTIVIIVQPVFFSERTLPFPCVLPVDWSNTYMYIPIYIIHVIVMQLAVCLGVIGTDYLLLAICIYTANQYYLLQRCFLVFNTSEMKEVNQELTILSKDSMEQYSNCLEKEYLLRCVKHHTMLVRFTKDFNKTFNPLEIGQLINSVWGVCLGTFILSRDDVSIYQTAAAIIYSSGFVMQLGIDCVMGNEMWYQASLIPDCLFQSNWKSLEKEEIKKDVLFILQNTQRFPQFTAYGLYDMNMTSFIKVLKVAFSAYTFLTNVSNTQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCS4</accession>
    <name>A0A6P7FCS4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326944</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131223.1">
        <property type="nucleotide sequence ID" value="XM_028275422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCS4"/>
    <dbReference type="FunCoup" id="A0A6P7FCS4">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275422.2">
        <property type="protein sequence ID" value="XP_028131223.1"/>
        <property type="gene ID" value="LOC114326944"/>
    </dbReference>
    <dbReference type="GeneID" id="114326944"/>
    <dbReference type="KEGG" id="dvv:114326944"/>
    <dbReference type="CTD" id="6224"/>
    <dbReference type="InParanoid" id="A0A6P7FCS4"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028131223.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13587" checksum="CEB79B39BA3889AD" modified="2020-12-02" version="1">MASVEKANPEKPGQESAPIHHIRITLTSRNVRSLEKVCSDLIDAAKRQKLKVKGPVRMPTKILRITTRKTPCGEGSKTWDRFQMRIHKRVIDLHSPSEIVKQITSINIEPGVEVEVTIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFS2</accession>
    <name>A0A6P7FFS2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114329848</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134904.1">
        <property type="nucleotide sequence ID" value="XM_028279103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFS2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279103.2">
        <property type="protein sequence ID" value="XP_028134904.1"/>
        <property type="gene ID" value="LOC114329848"/>
    </dbReference>
    <dbReference type="GeneID" id="114329848"/>
    <dbReference type="KEGG" id="dvv:114329848"/>
    <dbReference type="InParanoid" id="A0A6P7FFS2"/>
    <dbReference type="OrthoDB" id="6765403at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027893043" evidence="4">
        <location>
            <begin position="24"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028134904.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="70808" checksum="3B69FC9BD633C6C0" modified="2020-12-02" version="1">MASLRKWLFLYFITNFYVMEIMCTEDCREDKKTINKIIPAHYKPNPRQPWSQIYVSEQREEIITGLNISCKNVKLPLHYVVKGSCNNCTQILTILSSNLSEIPPSSFVNTKTISRLILKNLNILKLSPGAFVQRSLVEINLSKNRLSEIGLGVFNSLDNLETLDLSLNQISKLETQSFSGMTNLKSLNLSHNSLLAFSYKVFDPNIHPMEALDLGFNPILHLTVEINIKIESLFLNNNELNELNFCPHLFNTVSLKNNHLKNLSSTFCTSKGNDLISFDVSCNNISSIGDFYFGEALKLQSLNLSHNNLSLLSPGVFYNMSNLKYLNMSYNNLKDFMFGTFDSLNNLDTLDISNNNFYTISASLHSLTSVNQLFIQNNHVQDINPDQLQTYFPQLKKIFFDNNNLSCDNVVNIVRKLKASKVEILHNNLRNSTNVHGLTCLGTPDIALIPKTLNKTDNETLKDYFDEIKNSSLYQMLEHIYSSEKGKNVGYSKNVTSDKSLTDKYLEDNLKNTQNFTNYFREFIENQKKIVTADNEVNTKLYKYIHELSHSQETKTNILDPEKLAYTETSGYNKMVLVLSINTVFIILLCLIALLIGYVLFKNNNSRAPNVREHVELLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJA1</accession>
    <name>A0A6P7FJA1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114329981</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028135077.1">
        <property type="nucleotide sequence ID" value="XM_028279276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJA1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279276.2">
        <property type="protein sequence ID" value="XP_028135077.1"/>
        <property type="gene ID" value="LOC114329981"/>
    </dbReference>
    <dbReference type="GeneID" id="114329981"/>
    <dbReference type="KEGG" id="dvv:114329981"/>
    <dbReference type="CTD" id="39203"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19218">
        <property type="entry name" value="SET_EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044439">
        <property type="entry name" value="EZH2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="14">
        <location>
            <begin position="507"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="615"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028135077.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="86151" checksum="C5A84D048A277D45" modified="2020-12-02" version="1">MAKAKVNVDWKRRVKQEYMRLRQIKRYKRADDVKLAWNQNRSKMSEILIEEQKRWTDGKAFWGNTPELPAHSTCMKKAEVIGNEGDIQVTTIKIMNAVTPIPTMYTWAPIQQNFMVEDETVLHNIPYMGDEILDQDGTFIEELIKNYDGKVHGDRESGFIDDELFVELVHALVNYQEKDKGDKGEKKKEEKEKEKEKDKEKKEKVEETKDKKKDDMDFPTFVIFQSISSQFPDKGGPEELRDKYVELTERTDPNAPPECTPNIDGPNAASVPREQTLHSFHTLFCRRCFKYDCFLHRLQVCHPGPNLQKRRGPDLKPFTDPCGTDCYLLLDVVKETMAARAKQEEESEKEKEKEVKAKVPTKTAAETVTELKTNGVSNQSPRKICKQQSVDSGNEASSEDSNDSNKYKDNDNSDPVSTTTSFSLLGLMGANDHKEWTGSDESLFRGLHKVFLNNYCAIAQIMLTKTCQQVYHFAQKESADIPPEEQIRDYTPPRKKKKKHRLWSMHCRKIQLKKDSNSNHVYNFTPCDHPGQNCDHNCPCIGAQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQTCGADQFDNTKITCKNVSVQRGLHKHLLMAPSDVAGWGIFLKDSAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVNGDHRIGIFAKRPIQPGEELFFDYRYGPTEQLKFVGIEREMEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKK5</accession>
    <name>A0A6P7FKK5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114331234</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136531.1">
        <property type="nucleotide sequence ID" value="XM_028280730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKK5"/>
    <dbReference type="FunCoup" id="A0A6P7FKK5">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280730.2">
        <property type="protein sequence ID" value="XP_028136531.1"/>
        <property type="gene ID" value="LOC114331234"/>
    </dbReference>
    <dbReference type="GeneID" id="114331234"/>
    <dbReference type="KEGG" id="dvv:114331234"/>
    <dbReference type="InParanoid" id="A0A6P7FKK5"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF527">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028136531.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26125" checksum="E6D11E1682D42CE7" modified="2020-12-02" version="1">MGWGSKLDGCGNFIKYSLFIVNFIIFLGGVIVVAIGIWTIVDKSFANDLLGTNLYAGAAYILLATGILVTFISCLGCWGSVKEVRCMLVIYFIIIFLIFVTMLVGGILGYVFRGKIDQTIRLGMESSLRDYGQMKEITNAWDETQTRLKCCGIYDYKDWQNNIPTSCCKQTSNGNRVSCNSVLGNNEFTIYERGCLNVTKDYVKAHAVVIGTAGVVVACLMILGMIFSCYLFKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLK7</accession>
    <name>A0A6P7FLK7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114331526</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136921.1">
        <property type="nucleotide sequence ID" value="XM_028281120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FLK7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281120.2">
        <property type="protein sequence ID" value="XP_028136921.1"/>
        <property type="gene ID" value="LOC114331526"/>
    </dbReference>
    <dbReference type="GeneID" id="114331526"/>
    <dbReference type="KEGG" id="dvv:114331526"/>
    <dbReference type="InParanoid" id="A0A6P7FLK7"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028136921.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13156" checksum="818DD7F4929344E7" modified="2020-12-02" version="1">MSTNIIPDNLQDLRACLVCSLIKTIHQFKKDGCNNCETFLKLKNNTDNIYDCTSSNFKGTVCMMNSKDSWVCKWQRIQEFSPGMYAISVCGRLPKAVIRDMRNRGVSYKNRDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FNK9</accession>
    <name>A0A6P7FNK9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Troponin C isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114329599</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134565.1">
        <property type="nucleotide sequence ID" value="XM_028278764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FNK9"/>
    <dbReference type="FunCoup" id="A0A6P7FNK9">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278764.2">
        <property type="protein sequence ID" value="XP_028134565.1"/>
        <property type="gene ID" value="LOC114329599"/>
    </dbReference>
    <dbReference type="GeneID" id="114329599"/>
    <dbReference type="KEGG" id="dvv:114329599"/>
    <dbReference type="CTD" id="33752"/>
    <dbReference type="InParanoid" id="A0A6P7FNK9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028134565.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17108" checksum="7D2EC57B5418E1B2" modified="2020-12-02" version="1">MNDEEQKMAILRKAFQMFDTKKSGYIETIKIATILNSMGQLFDETELNNLITKSDPDRCGQVNFDGFCDIATHFLEEDDDESTQQELKEAFRLYDKEGNGYITTATLKEILRALDDKLTMRELDGIIAEIDTDGSGTVDFDEFMEMMTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUA5</accession>
    <name>A0A6P7FUA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC114334080 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114334080</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139896.1">
        <property type="nucleotide sequence ID" value="XM_028284095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUA5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284095.2">
        <property type="protein sequence ID" value="XP_028139896.1"/>
        <property type="gene ID" value="LOC114334080"/>
    </dbReference>
    <dbReference type="GeneID" id="114334080"/>
    <dbReference type="KEGG" id="dvv:114334080"/>
    <dbReference type="InParanoid" id="A0A6P7FUA5"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028139896.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="43069" checksum="51D9D1B3F9AC5922" modified="2020-12-02" version="1">MTKVCRLCLIKLQRGSKYFNINAVESFTGFMPYRDQLTTCIPEMALDLIPNPVICNNCRTALKSAYDFKNRCLFVEKKIQNYIEGQDGHDEVSYDLSLISCEDMPPFNKMTLLIPPVDNDEDSNTIEAVEPDKFLKIQSEEPVPTESLDNTTVSEESFRPSILKKPHKPHKPYPRGRVCNRYKSDEFVCNFCNEAFGSLQFLRKHNSVCSKSTQEPPKNILTKRPHLPTKAKNHLKKWLFRHTDHPYPTDQEKQRLMQETNLSLLQVENWFINARRRILQDLTRLKRRGFSADFVIAEDMYASPVGLEMDYEELVVSHITEKPQSTSGPSPVEEVNLPPPSENLIKEELQEEDIEEDEIDLSKVKCEVLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FV39</accession>
    <name>A0A6P7FV39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114331406</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136793.1">
        <property type="nucleotide sequence ID" value="XM_028280992.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050516910.1">
        <property type="nucleotide sequence ID" value="XM_050660953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FV39"/>
    <dbReference type="FunCoup" id="A0A6P7FV39">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660953.1">
        <property type="protein sequence ID" value="XP_050516910.1"/>
        <property type="gene ID" value="LOC114331406"/>
    </dbReference>
    <dbReference type="GeneID" id="114331406"/>
    <dbReference type="KEGG" id="dvv:114331406"/>
    <dbReference type="CTD" id="43936"/>
    <dbReference type="InParanoid" id="A0A6P7FV39"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000008">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="115"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="306"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028136793.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="68658" checksum="B14B5BF86555D31C" modified="2020-12-02" version="1">MLSFIPRSLRSVTANAGHKTILNQIPRTINAEDQHKRHLTGDVISPGQVMGIEHLRDPRLNKGLGFTLEERQALGIHGLQPARFKTQEQQLELCRISVERYQEDLNKYIYLTELQDRNEKLFFRLLSENIETLMPIVYTPTVGLACQKFGLIYRRPRGLFITINDIGHVYDVVKNWPEPDVKAVVVTDGERILGLGDLGACGMGIPVGKLALYTALAGIKPHECLPVVLDVGTNNQALLEDPLYVGLRQKRSTGKLYDDFLDEFMEAIVTRYGQNTLIQFEDFGNHNAFRFLYKYREQYCTFNDDIQGTASVAVSGLLASKRLTNKKLSDNKFLFLGAGEAAIGIADLTVKALENEGLSEQEARDKIWMVDIDGLLALERPEGGLDGHKKYYAKNHAPIKDFAAIVNEIKPSILIGASAAAGAFTPEILKNMAAFNERPIIFALSNPTSKAECTAEQAYVNTEGRAIFSSGSPFGKVHYGDKVFQPGQGNNAYIFPGVALGVILAGIHHINEQIFLIASETVAKNVSDEDLKRGSLYPPLSSIKECSMQIACEVLEYAYQERIASVYPKPKDMRKYIESHQYNYNYEPSLPQIWPWPNPPYIKTRPMEPTKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWC0</accession>
    <name>A0A6P7FWC0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein N-lysine methyltransferase FAM173B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114331770</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137218.1">
        <property type="nucleotide sequence ID" value="XM_028281417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWC0"/>
    <dbReference type="FunCoup" id="A0A6P7FWC0">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281417.2">
        <property type="protein sequence ID" value="XP_028137218.1"/>
        <property type="gene ID" value="LOC114331770"/>
    </dbReference>
    <dbReference type="GeneID" id="114331770"/>
    <dbReference type="KEGG" id="dvv:114331770"/>
    <dbReference type="InParanoid" id="A0A6P7FWC0"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF9">
        <property type="entry name" value="FI06469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028137218.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22135" checksum="220806EC050D7714" modified="2020-12-02" version="1">MNTLFETSEQTEPRSLPKKISPAGKFFVAITGGVAIGLTVICAPFISPAFRKYCLPYIPATDHQVKNILAALKGRTGTLLDLGSGDGRIVLETAKNKFISHGVELNPWLVLFSKISALREGITNAKFYRRDLWKYSIHQYDNIVIFGVEQMMNDLEKKFIKECKSSCKIIACRFPLPNLTPIKTIGHGIDTVWVYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZC4</accession>
    <name>A0A6P7FZC4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114335847</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114335847</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141939.1">
        <property type="nucleotide sequence ID" value="XM_028286138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZC4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286138.2">
        <property type="protein sequence ID" value="XP_028141939.1"/>
        <property type="gene ID" value="LOC114335847"/>
    </dbReference>
    <dbReference type="GeneID" id="114335847"/>
    <dbReference type="KEGG" id="dvv:114335847"/>
    <dbReference type="InParanoid" id="A0A6P7FZC4"/>
    <dbReference type="OrthoDB" id="6780401at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028141939.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="55288" checksum="AA92911D73E80709" modified="2020-12-02" version="1">MAFILPDNILETLLCNFCHKYLSVKPIKVHPNRLIQCGRCIENTDKSMHKSEAVESQYGKIAKNMLFKCVNRFDGCRQLLTYSQVSDHEQVCLERIHECPICGEDMVSLLMLRHFHSNHRDAILESPAFLFKLNDLLDVPSVYIYQEEDNLFFLYISYSKSENTIKLYLLYIGIYKLAKNIYHEFTVSSENKDFDIVLNPKPCTDDFFVVDISHIMTNLIQIKFKLIDRNLKVLTAPEISNAVRSPIVKNAPLESQIEHRSEFNLKCNICQAYCIFSLTGCPVMYYYIDEKNSYVCYYCTQYFKLKIDEASAERTIPINIFETMKFFKWNCSNCCSDFEFSDIQSHEINCKLGRQFTCPRRNCNEKGTASQMIEHLKDWHFCMAFGSHFKLPIDFIKCYVFVKEYIVFLRETNTLEFTSFRHKYIHVELVTKTDNDRKSPLALFFNNNNEILRNYKCGCESEVFVKVFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0Z9</accession>
    <name>A0A6P7G0Z9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RuvB-like helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114336343</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 14">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="RefSeq" id="XP_028142531.1">
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
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    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0678">Repressor</keyword>
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    <keyword evidence="10 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="68"/>
            <end position="360"/>
        </location>
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    <sequence length="465" mass="51821" checksum="879CE40BF0C4C08A" modified="2020-12-02" version="1">MAAAAAAKIAEVRETTRVERIGAHSHIRGLGLDDSLEARHVSQGMVGQVTARRAVGIVLQMVREGRIAGRAVLLAGQPGTGKTAIATALAHALGQDTPFTSMAGSEIYSLEMSKTEAITQAIRKSIGVRIKEESEIIEGEVVEVQIERPATGIGAKVGKLILKTTDMETVYDLGGKMIDSILKEKVQSGDVITIDKATGKITRLGRSFARARDYDATGQQTRFVQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGDTGEIKPEVREQINGKVAEWREEGKAEIIPGVLFIDEVHMLDIECFSFLNRALENEMSPIVIMATNRGITKIRGTTYKSPHGIPLDLLDRTIIVPTQPYDEKELREILSIRCEEEDCQMSDNALTVLTRICKETSLRYGMQLIMTSSLIARKRKAHEVDVEDIKRAYQLFFDEGRSVQFLREYQQEFMFNEIDDKDDMEIETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2U9</accession>
    <name>A0A6P7G2U9_DIAVI</name>
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        <submittedName>
            <fullName evidence="5">Post-GPI attachment to proteins factor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114333261</name>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
        <source>
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        </source>
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                <consortium name="EnsemblMetazoa"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="20"/>
            <end position="46"/>
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            <end position="246"/>
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            <end position="250"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF10277"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028138930.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31524" checksum="130F9C0F2E6668A0" modified="2020-12-02" version="1">MFSLLEHTKEERFHVHYRLSFKQVCLITVSCPFLALIVCFITAYIYQYDDIHETHCRVFNIVPSISAITGISPQRYIWRISIAFHVGPRLIISAVYRAYHLTLINPLAQKEVQEKAQFWLNVAFWLNVIETGSLCGVTYISNRENYAIHEKLFITFMVSSLTHMLACIQGMKAVADTRDVTQNTQINSCLYLKQLLFNVSILMTVGLVGFFLQHRLLCHRMAFSMFALCEYIIALANMAFHVTVILDFPTEHFMVAKQLHTQEGDSKSASLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBF7</accession>
    <name>A0A6P7GBF7_DIAVI</name>
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        <submittedName>
            <fullName evidence="5">NEDD8 ultimate buster 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114340032</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028290743.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_028146544.1"/>
        <property type="gene ID" value="LOC114340032"/>
    </dbReference>
    <dbReference type="GeneID" id="114340032"/>
    <dbReference type="KEGG" id="dvv:114340032"/>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000058">
        <property type="term" value="P:regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubl_NUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039749">
        <property type="entry name" value="NUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041207">
        <property type="entry name" value="NUB1_ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948:SF3">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18037">
        <property type="entry name" value="Ubiquitin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028146544.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67276" checksum="6898DB80D22A8117" modified="2020-12-02" version="1">MSNTLKKEDYLIQIRDKLRRDGIKLWLPPYFKGSNASEDDIKNLSEDFSKHLNIPCDICQEIIKDLQDNALENLKQKNHYKESGLATVKIKILHKNSPPRLIQKELLLSMMTNELKDLVRNEISVSSEGLKLICSGRVLNDLDSLGSQGVKNGAQMLAIILSETPTQVFQAENQIKELESVKTDSKLLALDNEYMQLEDQFGNPIKIPPKERKALVVAMALHEKGKTALKRNDYTRALVFFLEADQEFSQCNSQLLKTVDNYALLDLDIAWCYLCLESFVQLPEAESRLKRCEEKFHSTYGNNLERLVAVKGTPGNEEALMMRLHLLQAIVLYHQNKRAEALLLLRKVEEEINSLKVDGDSVVTLIELGYTSKEATLGLRAARGNVNEAANYINENREKRAEGRKKAEAEAILEKERKKLGLCKDGKQYVDPKFVKILVNMGYSKETARVALKNTNNIISDSIQYIQENPLPGSSSSKSTEMLSFVDDLTKQLEEAGFDPRMAKLALSKHSGDIMKAAEELIANDGIILGDLSNYFGAESLDNIKKRRQDDKEKNEAFQRLKEDIDIVDDDYLDINLVQEEVFLKQYLSLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBZ8</accession>
    <name>A0A6P7GBZ8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Baculoviral IAP repeat-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335746</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141840.1">
        <property type="nucleotide sequence ID" value="XM_028286039.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7GBZ8">
        <property type="interactions" value="2271"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286039.2">
        <property type="protein sequence ID" value="XP_028141840.1"/>
        <property type="gene ID" value="LOC114335746"/>
    </dbReference>
    <dbReference type="GeneID" id="114335746"/>
    <dbReference type="KEGG" id="dvv:114335746"/>
    <dbReference type="CTD" id="41260"/>
    <dbReference type="InParanoid" id="A0A6P7GBZ8"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000014">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022103">
        <property type="entry name" value="BIRC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12356">
        <property type="entry name" value="BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="4005"/>
            <end position="4172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3434"/>
            <end position="3459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="3434"/>
            <end position="3443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028141840.1"/>
        </source>
    </evidence>
    <sequence length="4293" mass="479437" checksum="E1367F5CCEF97011" modified="2020-12-02" version="1">[encoded data, 4293 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GC56</accession>
    <name>A0A6P7GC56_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Probable cytochrome P450 6a13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114336295</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142438.1">
        <property type="nucleotide sequence ID" value="XM_028286637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GC56"/>
    <dbReference type="FunCoup" id="A0A6P7GC56">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286637.2">
        <property type="protein sequence ID" value="XP_028142438.1"/>
        <property type="gene ID" value="LOC114336295"/>
    </dbReference>
    <dbReference type="GeneID" id="114336295"/>
    <dbReference type="KEGG" id="dvv:114336295"/>
    <dbReference type="InParanoid" id="A0A6P7GC56"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028142438.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="59901" checksum="D7B51DE7A6A498E8" modified="2020-12-02" version="1">MEIITIFLYTTVMVLSLYFFFKWNYSYWSRIGLEYLQPLYFFGNTISLLYGVSMGDTFKKIYNDMKAKGFKHGGLFFFFLPLYMPVDLDIVKNVLQNSFEHFMNHGIYHDEEREPITAHLFSLENDRWRMLRKKLSQTFTSGKIKMMYPTLFSCSAGIKDRLQKHAELQDAVDIKDLFMRFTIDVISSVAFGLNSNSLKENESEIIDIAYKMFDAVSPRERLKEAAIFLFPKRFLQAIKFKFMNANIENFFFSMVGGTVKYREANNIYRKDFMHLLLQLKNRGKLSDDKRIISEEGEQIGEDFISFNELVAQCFVFFTAGFETSATTLSFAMLELALNPDIQEKLREEIITVLDDHDGEFSYEAVMKMEYAEKVIFETLRKHPPGPVIPRICTKDYNVPDTNITIKKGTRVVIPGLAIHNDPDIYPEPEKFDPERFSEENKAKRHPCAFLAFGEGPRYCIGSRFGILECKVALAIILSNFRIGLHKKTKIPIKYAYTNAFILGVKGGIWITVSNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGG8</accession>
    <name>A0A6P7GGG8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="8">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="8">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114342252</name>
        <name evidence="8" type="synonym">KATNA1</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
            <location evidence="1 8">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Microtubule organizing center</location>
            <location evidence="8">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Spindle pole</location>
        </subcellularLocation>
        <text evidence="8">Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028148841.1">
        <property type="nucleotide sequence ID" value="XM_028293040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519284.1">
        <property type="nucleotide sequence ID" value="XM_050663327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGG8"/>
    <dbReference type="FunCoup" id="A0A6P7GGG8">
        <property type="interactions" value="1145"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293040.2">
        <property type="protein sequence ID" value="XP_028148841.1"/>
        <property type="gene ID" value="LOC114342252"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663327.1">
        <property type="protein sequence ID" value="XP_050519284.1"/>
        <property type="gene ID" value="LOC114342252"/>
    </dbReference>
    <dbReference type="GeneID" id="114342252"/>
    <dbReference type="KEGG" id="dvv:114342252"/>
    <dbReference type="InParanoid" id="A0A6P7GGG8"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000025">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000003">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF19">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="261"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="269"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028148841.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="58138" checksum="63F4AD937D2FD32D" modified="2020-12-02" version="1">MAVTIKEICDNIRLAREMSMLGNYENAEVYFEGCLQMITKLILMISEPLRKNKWQQVQKKVSTEYEEVKMIKSMLQNLRLETSSEVPIGARRRDEPVRDFGDMNNADPFSQNDPDVWPPPTPVDHNSIPKSRPSVVRKSEAKKMPVSSRSSSSAARKSEISRYSRSVKKDDRPTSSRSERDQKESESGDKTEKPETEEEKKFECHILDRELADTLERDIIQKNPNVHWDNIADLQEAKRLLEEAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSTSTLGSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEASRRVKSELLVQMDGVTASDEPGKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPTQEGREALLRINLSEVKLDPDINLKTIARRLDGFSGADITNVCRDASMMSMRRKICGLRPDQIRQLPKEELDLPVTMKDFEEALVKNNKSVSKEDLEKYERWMSEFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHX5</accession>
    <name>A0A6P7GHX5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114342865</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149471.1">
        <property type="nucleotide sequence ID" value="XM_028293670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHX5"/>
    <dbReference type="FunCoup" id="A0A6P7GHX5">
        <property type="interactions" value="1112"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650858.1">
        <property type="protein sequence ID" value="XP_050506815.1"/>
        <property type="gene ID" value="LOC126884728"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GHX5"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="190"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="420"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028149471.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="59442" checksum="96B4F344ABB27F0E" modified="2020-12-02" version="1">MSLLSARLAASLARNAPKNVTQIAGAVFPAASVAARNFHATPQNKGAEISSILEERILGAAPKANLDETGRVLSIGDGIARVYGLNNIQADEMVEFSSGLKGMALNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGDQILGRVVDALGNPIDGKGPLNTKQRFRVGIKAPGIIPRISVREPMQSGIKAVDSLVPIGRGQRELIIGDRQTGKTALAIDTIINQKRFNDAEDEKKKLYCIYVAIGQKRSTVAQILKRLTDTGAINYTIIVSATASDAAPLQYLAPYSGCAMGEFFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSEAHGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLDAATQQLLNRGVRLTELLKQGQYVPMAIEEQVAIIYCGVRGHLDKVDPSKITVFEKQFSEHIKTSHKNILQSIAKEGKITDDTDAQLKKVVQDFLASFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKN6</accession>
    <name>A0A6P7GKN6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Microfibril-associated glycoprotein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114343833</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028150476.1">
        <property type="nucleotide sequence ID" value="XM_028294675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653652.1">
        <property type="protein sequence ID" value="XP_050509609.1"/>
        <property type="gene ID" value="LOC126886656"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GKN6"/>
    <dbReference type="OrthoDB" id="6350391at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028006636" evidence="7">
        <location>
            <begin position="25"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028150476.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35900" checksum="80867E5AB1A8D3BC" modified="2020-12-02" version="1">MGLKEMYYNLSIVFLLLASSSAFTQDNNLGITQTQDNNKITLTIQIQKPNSHEGIRGATILGNGISNSVEVCQHLVGVSKGDYCPITETKVTNLNIPGSCQEIYRNGKTISGTYEILPTGQTKPVTVLCDMEIEGGGWTIIQKRFDGSVDFYRPWRDYKFGFGNLKGEFWLGLENIHHLTSSKSNELLIEVTDHNLLNYYARYPVFEIGSEYQGYKLKTLGSYSGNSSGDSMIYHLSQRFTTFDQDQDSWSEGNCAKFSHGGWWYNNCYSSNLNGSPRNIPHISPKDTSKRYGMNWDKITTPSQSHLYGTRMLIRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GN40</accession>
    <name>A0A6P7GN40_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114344425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114344425</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151059.1">
        <property type="nucleotide sequence ID" value="XM_028295258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GN40"/>
    <dbReference type="EnsemblMetazoa" id="XM_050641203.1">
        <property type="protein sequence ID" value="XP_050497160.1"/>
        <property type="gene ID" value="LOC126878463"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GN40"/>
    <dbReference type="OrthoDB" id="8194095at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027748210" evidence="3">
        <location>
            <begin position="17"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028151059.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55291" checksum="FFE63D1007A364A1" modified="2020-12-02" version="1">MLRFLVIVAMILFVDTFRLPRNNSAILISKYAKVVKWGNKDEKNNTQPVSSKSRTAVWTARSSSTSNRLNEPMYQYPVYRKEDHNNIEVVPAIGEVIQDRFQVPPYFPYKTKDSGITYLPPTQAPITAFTSAPVASSVKGLSLPQSFTAPNFDPNSFSSSINQNKAVSSASSTSDFYDSPFNSYNPPPAGNPDDSKNNYAPNLDQPDNTDSDGQNSYTNSPQDDGGPYNFAPTLKQPMAMSNRPGPVKSNSFDDASFLPDTYGSPNYVQTSQENHSVLDDDAERPKHPPRNIDDIYYPPSFPRDQIEENHNNNPNVIGSNPQDHVVPMLNIPPHDLSQPPTDMIPQDQKVSLMNIGPSSSSGLHNDFPKYLYDDHHFDHHIYEEVHHATTPEPEKKRVSTTNYSYYYLGRKLWYIPLYFSIYFMVYVTALIIKSIARRKVTLRNQYITANTRSRRDLTLDHMDALDEVHHNISTAIDKVDKMYSRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GS79</accession>
    <name>A0A6P7GS79_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drosomycin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114341540</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028148138.1">
        <property type="nucleotide sequence ID" value="XM_028292337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GS79"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648952.1">
        <property type="protein sequence ID" value="XP_050504909.1"/>
        <property type="gene ID" value="LOC126883406"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7800919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Drosomycin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
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    </dbReference>
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        <property type="entry name" value="Knottins"/>
    </dbReference>
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        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00304">
        <property type="entry name" value="Gamma-thionin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Scorpion toxin-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027776039" evidence="4">
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            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028148138.1"/>
        </source>
    </evidence>
    <sequence length="66" mass="7056" checksum="0DBEBCB5A6DFBF75" modified="2020-12-02" version="1">MKGYIIFAILLILTIGTELAFGDCLSGRYGGPCAVWDNEACRRVCHEEGIGGGHCSASLKCWCEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTM6</accession>
    <name>A0A6P7GTM6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114342121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114342121</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148708.1">
        <property type="nucleotide sequence ID" value="XM_028292907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTM6"/>
    <dbReference type="EnsemblMetazoa" id="XM_050641468.1">
        <property type="protein sequence ID" value="XP_050497425.1"/>
        <property type="gene ID" value="LOC126878640"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641469.1">
        <property type="protein sequence ID" value="XP_050497426.1"/>
        <property type="gene ID" value="LOC126878640"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GTM6"/>
    <dbReference type="OrthoDB" id="6752317at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028148708.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20119" checksum="DACB4203F04F1F54" modified="2020-12-02" version="1">MCDNQTHKAVRLFPRNNRWTGPSSSLEDRSKCMNMRLRLPPDIVIRQSRETFFKRLRINRSRSVDRFRQIVENYGEFMNYRSISHLKTILESDLEAATLMTDVDVNDVLNDIERELAQVDLQDEAAKYELDVQSQTQDIVNRLLPVCKVCLRENTEGDICGLCATSLDSEFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GVG2</accession>
    <name>A0A6P7GVG2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114347204</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028153736.1">
        <property type="nucleotide sequence ID" value="XM_028297935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GVG2"/>
    <dbReference type="FunCoup" id="A0A6P7GVG2">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297935.2">
        <property type="protein sequence ID" value="XP_028153736.1"/>
        <property type="gene ID" value="LOC114347204"/>
    </dbReference>
    <dbReference type="GeneID" id="114347204"/>
    <dbReference type="KEGG" id="dvv:114347204"/>
    <dbReference type="InParanoid" id="A0A6P7GVG2"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028153736.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59017" checksum="8F0DF9F55D0F140B" modified="2020-12-02" version="1">MYSKITAIFSLLVFCSVSYVNPLKILGVFPYAGPSHYFLGNELLKGMAAAGHDVTMITVFEDKNPPKKGTYRQLILQEVLQLQYDMFANMSKLSGGDSFSAKGPFGMLSVFSMIGLAITEGTLSHPTVQALIKSDEKFDVMILTQFAVEGTKALAAHFGAHLVLFNDNAATCWVNHFVGNSGLPSLNPELVFDYPQLMNFKQRLTNTLYTMAAYLYHNYVQYPAHAELIKKYVSKDMDLTKIQYNVSLVLSNSHPSLNNPAASVPNMKEIAGYHVKEPKPLPADLKKYLDESKNGVIYFSMGSTILSSSLPKEKRESILKAFSKRKENVLWKFEDENLPGKPKNVRIEKWLPQSDLLAHPNVKLFITHGGFLSTIETMYHGIPTVSVPVINDQKTNARQAEKNGISIVVDYNTLTEEQLSEAIEEILSNPRYRENAKARSKIFHDRPLKPMEEAVYWVEYITRHNGAKHLRVGYVDLAWYQYYLLDVFGFIFGALFLALYVIRRALCSLYCLVSGGTAKKVKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H9B1</accession>
    <name>A0A6P7H9B1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114348996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114348996</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155237.1">
        <property type="nucleotide sequence ID" value="XM_028299436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H9B1"/>
    <dbReference type="FunCoup" id="A0A6P7H9B1">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645495.1">
        <property type="protein sequence ID" value="XP_050501452.1"/>
        <property type="gene ID" value="LOC114336078"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645496.1">
        <property type="protein sequence ID" value="XP_050501453.1"/>
        <property type="gene ID" value="LOC114336078"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H9B1"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF26">
        <property type="entry name" value="RH26557P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028372382" evidence="3">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028155237.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="38291" checksum="F5A91C8694E3313C" modified="2020-12-02" version="1">MMRLVLLAALLSISSSEDAVSLNPFKQSYVCPPKFIRQGHRCYFFSKEAITWSEALFQCREMHSNLAIIQNRNQDKLIRSFLSKKTLDPLERWLGGVYDWGKMAWKWAAPGKPLAYNGFSKEVNPQDPETLRWHCIIMDPTQQYFWSSRSCVERKHYICQTRLKTVNNRDKKRLQRQYKASKDNRLNEIPVPYIPDFPNNTTALKYNALPITYHFEPNDKLSDNAMFAYKSPEYKKPVRRNGQRKKKSNSLRPMRPLRLANGTVIERPRKRVTHRRRKQRKPEDLGKPTLIKNIRWKTYKKNGNLPNPLYPRPIVEEYNYVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HBC1</accession>
    <name>A0A6P7HBC1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114348642</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="RefSeq" id="XP_028154968.1">
        <property type="nucleotide sequence ID" value="XM_028299167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HBC1"/>
    <dbReference type="FunCoup" id="A0A6P7HBC1">
        <property type="interactions" value="1594"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646700.1">
        <property type="protein sequence ID" value="XP_050502657.1"/>
        <property type="gene ID" value="LOC126881956"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HBC1"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="57"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="285"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028154968.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="55592" checksum="283FFC3B36444FD6" modified="2020-12-02" version="1">MRGVVKMIQFLLFIIKLILAVVIFVVLSVGIVVPVYYLYLKRKYTVDKLKNLSSKLRVGIFHPYCNAGGGGEKVLWVALQALQKKYPKAEFYIYTGDVEATPEEILDKVRTRLNVNLDKNIKFIYLHRRKWLEANMYPYFTLLGQALGSVFLGFEALNRLNPDIFIETTGFTFVIPIFKYIGGCKTGCYIHYPIITNDMLKRVSNRQSLYNNRSIIARSPILTMGKLVYYHIFAWAYSLAGQSSDINLVNSTFTMEHLNSLWNRPLHLVYPPCETDHLKKIQRDKTRPKNIRIMSLAQFRPEKDHPLQLQALYELREIVPEDVFNNITLVLCGSCRNAEDSRRVKDLKDFSKHLSLENNVEFKVNINYGDLLEEFKNSWIGIHTMLDEHFGISVVEQMAAGLIMVAHRSGGPLLDIIETSEGSRLGFLAQTPDEFAHIIKFILQLDDAEVNEIRSKARASTDRFSNHKFHEEFLRAIEPLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I922</accession>
    <name>A0ABM5I922_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA 3' end processing protein WDR33</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127721.2">
        <property type="nucleotide sequence ID" value="XM_028271920.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028271920.2">
        <property type="protein sequence ID" value="XP_028127721.2"/>
        <property type="gene ID" value="LOC114324168"/>
    </dbReference>
    <dbReference type="GeneID" id="114324168"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127721.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="98795" checksum="5A5E2C6824998300" modified="2025-10-08" version="1">MDFAQPPPNMGMPPPNLAVGPPMAPMQGYGNRPPFRPFVNIHKPLPGPLSNMTLEDFDGKRLRKSVMRKTVDYNSSIIKELENRVWQRDYRDRRALQPDAMYYPDLMPPPSYPDNPINCVTTRFVKTATNKMRCPIFCMAWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRTMVWSHNDSWMITGDHSGYVKYWQSNMNNVKMFQAHKEALRGISFSPSDNKFVTCSDDGTLRIWDFFRYQEEKVLRGHGADVKCVHWHPQKSLIISGSKDNQQPLKLWDPKSGQSLATLHAHKSTVMDLKWNENGNWLITASRDHLLKLFDLRNLSQEVQTFRGHKKEASSVAWHPIHEGLFCSGGSDGAIMFWHVGADKEVGAIEQAHDSIVWTLAWHPLGHILCSGSNDHTSKFWTRNRPGDQMRDKYNLNTLPAGIAGLEDIDMGEEPISIIPGMGPEDKVEITSILTDENQAIPGLDLDGVVNEEKAKPKKVPFSKPIPRNFQAQWNETNDDTAGALNEVITQLVVENTPGAVPLNDIAPNALYIYDKVIPVEPGSKLQQALASGLDALNKLIASGEVEELYDVMPINDDEDGEDTKNQELGDSDMRDKKDVDFRNDRSFKGSRFSDSNDFDARRSLGDEDLRLRDRDEDFRFRKEDDDFRKGSMHEDKYRRDGDYRRDDNYRRNERRDDYRRDEDYRRNDDYRRDDDYFEDSPGKSGNWSRNGKFGNSFRGKRSDKPPYNSSFSGRKFGPSDSPEWDDTDPFDVISQEKWDNRSDDDFNEDWDLDDEDLDSEDLLDDEDNWLDSPRFSRGRGRRDERGRGRGGRSRGGRGRGGFGRGRGDRGGRRGSRGGRRGGSRGRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9V5</accession>
    <name>A0ABM5I9V5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128208.2">
        <property type="nucleotide sequence ID" value="XM_028272407.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272407.2">
        <property type="protein sequence ID" value="XP_028128208.2"/>
        <property type="gene ID" value="LOC114324548"/>
    </dbReference>
    <dbReference type="GeneID" id="114324548"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="145"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="569"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="752"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128208.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134008" checksum="958577BC94DD3FBB" modified="2025-10-08" version="1">MNPSSFDRECTNQCKSTIHGDVITDAISKRSISDQDLCSFLNFVCSRCESVIDSSGRTALHVAASCGRLNLVRWLILNRHADIHAKDRESSYTALHRSIFYGKIDVAVELVKLGANTSDLDLDYLTSLEHAMKDGLKPEAGISGGELYSWGSNNNNLLGPQQTKQSPDLLDSFHREYPGEYAKQICIAQFHSTIVTVSGKALTCGHGQGGRLGLGDEKTVVTPKVVNFIGHQKGEVVTCNQASISRDHSIFLCSDGNIYTCGLNTYQVLGQVPPPERSLVPKPIKHLSKEILGVCSSQYHSVAWGPDGLYTWGLNAGQLGVKTNEQKSKFIAAPKLITIAQDVSINHVASSNGAIAVCTTNGDIYVFHEYLCRKIASRQLNFIQVSIVGGTLDSSLLDKELAREINCELKVAVLTSDGNVLLWQGSDQQLCRCIYSINRAIVMKQIEMNLNELLMVSRDGEAFKGFIKPRKKRVTNQNKITNSVEKNQKTQKSAFHKFLEKEDCVVLSLQKITKIHRALSMISDLKGKDFAIIQAPPYKNFTFGDIERSEMKENFETLLLESDDCDTVHDVLFKINDKNIPAHKYVVANASPYLEKLMEKQDKVILNSINSEIFRQMLKFMYTGECELTKCGELKNETLKKLCYVKDSDRKDKEDVDDVIEVNEVDKDISAFEYYKNNQQQNKQKHTENKTKQSRNPVRLLHEMAKKYECVTLQKCLSNLEMSNYVIFSKNHAAHRSRMNINFDRLNFASFYDVTIKCRDNKTLSAHKCVLAARMEYFNNMFMRWHENSTAEVSLPFPKNTVEALLEYLYTDSLSKLNALEVDHLFNVVILADQLFVQRLKEQCELLLSDLLTMKNVIQVLSFADVYCANKLKYCCMMFIIANITPLLELKAFNDLDDDLLKELSDFYFDQKKEIHCRVITPYSTAESDEVIASIASTYPVSMSEEVDITPNKPVHKKRNRPHRTSEKSNSISEKDASYDSIIQFPDEPDIIAEVDNKITELPNRLKSITLASKIVKEELVQENFTKLNKSSLSVSFDDSVQFPELGSSPVFSLTKASPQKTDTRTKPVKMSQKQRKRLSSESKAVDSPPIQVTPKNPWKILPEASSPVSTADPKHFGDIISDEKKQKENLLKLTNRPLLFTQMEDKAIDELHKFYNVENAFDELITIERVNIGAVACPVWVPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IC90</accession>
    <name>A0ABM5IC90_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129672.2">
        <property type="nucleotide sequence ID" value="XM_028273871.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273871.2">
        <property type="protein sequence ID" value="XP_028129672.2"/>
        <property type="gene ID" value="LOC114325739"/>
    </dbReference>
    <dbReference type="GeneID" id="114325739"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045824165" evidence="1">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129672.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="134" mass="14299" checksum="225A60217D7D9A8F" modified="2025-10-08" version="1">MYTKFTVVALLLCVALNEVHSGVILGKRLGRSLTACPDPLNPGILVSDNDISGGLFESINLRIPEIGLLETPISCILIVDKKKSSTDPIIGAGGVGSPYVEISIKPGFFESLHYRIEVYRKAPDTTPASTATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICJ5</accession>
    <name>A0ABM5ICJ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129850.2">
        <property type="nucleotide sequence ID" value="XM_028274049.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274049.2">
        <property type="protein sequence ID" value="XP_028129850.2"/>
        <property type="gene ID" value="LOC114325901"/>
    </dbReference>
    <dbReference type="GeneID" id="114325901"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129850.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="315" mass="36015" checksum="99ED253EE6F4F44C" modified="2025-10-08" version="1">MGLFRGFKAKFTRNSKPKNKSGEVVVPLNFRIKTEFDSPKPPDPVPNLRPALRTTNSRYNRPIPRSQYFEETSRAIQLKLQSTSLTNLPAATAEEKKSNNKKSSIEHEYEEPISPPPVPHSPPPVLNSPPPNANPRINNVNPLANSRINNVKEKRLTPPTEDEYYKSNSMYTPTKSFNIPYADDDYEEVTPTEEPSTLILMTQHSDSSLASYVKTPNTPENYFKNQSKVFDFPSETEEDFKVNVVNHDLSNYVSEDELTQDEEEYQTREESASQYPRASYSSQATNLFFGESEPVIQRPRKLRLRDVTETDEDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICW2</accession>
    <name>A0ABM5ICW2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130055.2">
        <property type="nucleotide sequence ID" value="XM_028274254.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274254.2">
        <property type="protein sequence ID" value="XP_028130055.2"/>
        <property type="gene ID" value="LOC114326056"/>
    </dbReference>
    <dbReference type="GeneID" id="114326056"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130055.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20430" checksum="9BAB222FCC8397C8" modified="2025-10-08" version="1">MPLTCIVVNCGSRSKRDKVSFFAIPKPLKFKHAIHLNELTVKRRKKWIRAIRRADLTESKLKYQKVCSKHFIQGQPAKLEDVNDPDWIPTQNMGYSRGPVKRKQDLERLERVKKRSSTKVSQEDNDTFIENENNTVSESNTTAMYEDSTGTETQTELTSDDIEQMAQQLKLIADSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFL1</accession>
    <name>A0ABM5IFL1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131674.2">
        <property type="nucleotide sequence ID" value="XM_028275873.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275873.2">
        <property type="protein sequence ID" value="XP_028131674.2"/>
        <property type="gene ID" value="LOC114327297"/>
    </dbReference>
    <dbReference type="GeneID" id="114327297"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131674.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="187" mass="21417" checksum="4764DE8769F3D2BB" modified="2025-10-08" version="1">MYVGSETLSSSERRQREMRRLILKIQKNKAASQTVTAKVYAPSDPEEEVTPEVEAKKPVTKEQVWEKKLKSVIELSLNTLVASLLNIPNKVEACHIAFCDDFKEGIVMVLERHRDRLQQSLEENNKESHILRKAVEDIFDYVDKMLEALDQDECRLMKDLNNTNTLLENAVRSDSRGLNNKNTADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFP4</accession>
    <name>A0ABM5IFP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131732.2">
        <property type="nucleotide sequence ID" value="XM_028275931.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275931.2">
        <property type="protein sequence ID" value="XP_028131732.2"/>
        <property type="gene ID" value="LOC114327343"/>
    </dbReference>
    <dbReference type="GeneID" id="114327343"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="269"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131732.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="567" mass="66764" checksum="7114CDDBD0D68634" modified="2025-10-08" version="1">MFKKKKLMNLTKSVDLNILCSLLEQKGHRIDMTLVEDFVKIKTIEDNKRENDRVRQVIFKFLKVIFQKTNQDERFHHFHELVQIIYHNISQKLLELKQVQSLLTKEEYKKIVRYSIPFVKLEIILEMFATKDRNLSYSKDVTILVEELVEYLKQPFLLREEVYEIAKNTLPDTDKNSKVTGYRLESVVDCGGYLSEYAKLEISIDKECVYRYFIKSLPKKPNDLHEVLTKPSFNKELLFYKEFIPTLKQLGAVHLDFLPECYMVGKDFMVLKDLAFEGYSSSFKCCCEYDHLLLAIRQLAKMHSLSIIFEEKMSKILGAKVKIDQCFPGVVVESQFLPQELTEAHIQHAANVLKRYPHLVNTSTSMEELTNKAVKKLSESYEVVKKSGKYRNVLTHGDLWTTNLFYKTDSNKQLEHCVLLDYQLMRYAPQALDLLMLLHVNTAKEVRQQRMQDLLHVYYSELRSILHNFDIDLEKISPFNDLVQSVQELKLFGVFAGTFLNNFVSLPKEQFHEILKDPKIDFWCNHIQREDAIQSLWDDVDPEWKKKIEENAEDLVELCENMQHIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFW7</accession>
    <name>A0ABM5IFW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein saal1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAAL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131837.2">
        <property type="nucleotide sequence ID" value="XM_028276036.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276036.2">
        <property type="protein sequence ID" value="XP_028131837.2"/>
        <property type="gene ID" value="LOC114327422"/>
    </dbReference>
    <dbReference type="GeneID" id="114327422"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF23">
        <property type="entry name" value="PROTEIN SAAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131837.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48240" checksum="378E6E3D1E8DDBCC" modified="2025-10-08" version="1">MENSKCNSEITKEDTKSEKNNTVVGDNCYKLSTNIDANDLDKETAEKLKGDTIGDTLYSQSFVLKTLLQFSELQWNEQVEEDLCFLWDMTVEKDVCEFLLGISYPSITAAAVVQHSENNRFVEIVIGVLANVFCSGCDNSMTKEEIAIVLSLLQSDDPLVLVQVMRFISLSVESSDLMISLVDEDIFEQLCFILKNSVNTDLLLKTMEAVAKLTTNFRIKEALVTYNVYDSVMICYNTLMKMDGDQFDPDTKEKVSSIRYMVEIIVNVYTFIERFEKNELLSQIQANSNIFVNEILKILGFFCLQENLLPITDNLTFIMSAISYTYTNLKLNYLPDIFLSVTKILEQLIDIKDEVGDIFDSTLELQCYLISCTKQEDIHRDLKCLSRSTVKKVLNVVNENFSKYSLSSDISDSLLKYYKQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIU2</accession>
    <name>A0ABM5IIU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028133811.2">
        <property type="nucleotide sequence ID" value="XM_028278010.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278010.2">
        <property type="protein sequence ID" value="XP_028133811.2"/>
        <property type="gene ID" value="LOC114329000"/>
    </dbReference>
    <dbReference type="GeneID" id="114329000"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045012676" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133811.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="524" mass="59796" checksum="5CD6BD718B5397B7" modified="2025-10-08" version="1">MARIISILVLFLIHSATSAKILSVIPSASRSHHLPFQPLWRELALRGHEVTVVTTDPQRNASIENLKEIDTSFCYKIYEKHNVVNAIANESLSSLEKAGVLRRAFLECEDYHFSLPPIREMIINKKIHFDLLIVEAQLPSMLAFSWRFKCPVIAVASMEPALQYHDSLGNPVHPVINPDYNLDVIDSENLTFKERLLSFLQVVIYKYHIYNRAFPAYHEHVKKYFGKDLPPLKELQDSISLMFIGSHPLFHNIRPLNLNTIPIGGGMHIKAPKKLPNDLQKFLDDSKTGVIYFSLGSNVNSNLLTTEFKKAVVEAFAEVPHNVLLKMDGEIEGLSKNVMVRKWMPQQDILRHPNIKLFITQGGLQSLQESVVNGIPLIGIPFFGDQITNVNKMVKKGYGVKVDRRSMTKEILVAAIRQVMTNPSYKETAEAMGEIFKDEEIPSLQRAVYWTEYVIRHKGAKHLRSPGIGMPAWKYYMLDVMGFLAFVCLTIIIGIFLILRGFFRWLKYLVKGDAKKTRKTKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILD8</accession>
    <name>A0ABM5ILD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Insulin-like growth factor-binding protein complex acid labile subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135636.2">
        <property type="nucleotide sequence ID" value="XM_028279835.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279835.2">
        <property type="protein sequence ID" value="XP_028135636.2"/>
        <property type="gene ID" value="LOC114330491"/>
    </dbReference>
    <dbReference type="GeneID" id="114330491"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046961895" description="Insulin-like growth factor-binding protein complex acid labile subunit" evidence="4">
        <location>
            <begin position="19"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135636.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49319" checksum="2A9E541420822140" modified="2025-10-08" version="1">MLCKVLVVLFTLFVCLKCSNISVELHINKFFKGVNITINSIFELKQNVVNRSEVHLIQIKDQNVPVIPKNFLNGTSVSDFGISRSQVREVEPGALDGVSLDFLNLNANNIARIKKGIFNKKSLYIVDFQNNVVSNIEDDAFAGATITLLDLSHNKMAKLTSKMFAGSNITYIFLHSNVISNIEDGTFDKIDNMQRLVLSNNQLEALGNVFKNLTNLKQLLLAENRIKTLEPGCFSGSGISLEIFLSGNQLTHIAKGVFYKVPVFSLDFRNNSISKIDKGALAGLSTLRNVLLGNNSLGDLKLSNFDFLNNTLNLLSLSDNGISNIDIGVFKNVEIFILDLSRNHIKSIKKGLFHNLTSYRIELSENEITEIEEDAFADIKDLSYIDVSMNKLKEVKKRMFSLGLNRVNLEDNLITKIDNDVLNGLSLSDIQIKNNPIAAKNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILJ4</accession>
    <name>A0ABM5ILJ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135737.2">
        <property type="nucleotide sequence ID" value="XM_028279936.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279936.2">
        <property type="protein sequence ID" value="XP_028135737.2"/>
        <property type="gene ID" value="LOC114330561"/>
    </dbReference>
    <dbReference type="GeneID" id="114330561"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="2">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135737.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="121" mass="13654" checksum="8361D3D75B2AE549" modified="2025-10-08" version="1">MNIIDFKKLTKTMSIWSVNCLILITMVFVVTQIQPQVNVEAAKIDREYCLNLCATAFFICPPLNCTSNQFIQSIPERCRCCAGCYTRLGEGDKCGDDDEALCDRGLICKENVCRKFEAQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMR1</accession>
    <name>A0ABM5IMR1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136648.2">
        <property type="nucleotide sequence ID" value="XM_028280847.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280847.2">
        <property type="protein sequence ID" value="XP_028136648.2"/>
        <property type="gene ID" value="LOC114331317"/>
    </dbReference>
    <dbReference type="GeneID" id="114331317"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046887399" evidence="1">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136648.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="403" mass="45596" checksum="77AB79F2360AE62C" modified="2025-10-08" version="1">MKRCQILIVCVFWLKTSISTPVHDEYSAFNTFQDVILRNEEIESLNEPLLSLHNANPDLTSICWAESLIITENKHTKNQTISKAYSILLDTPGNLQDLPANSENSSCYEVLEQNTDQKKVLNFTTVKESGDYIIKEHKTLFCGAGPILSHHFIVWPKLKRKQIEISINPLGKSNLRNCSDIEDSQQLESEDTNKMLGERTRSVADEDEIVGSQHTPNKEITQEESALPYPIPQIKHSHSNEDIFEEEVTTKKIGAMHGNKETVVAQASPPDNKSNKKQGPAPTVKNSLLMRDINCTVDELGVCKYMIEKGKNCTGSANSSKIVLGKWFFPDVALAEPLDKERTFILNIKLIVNLKENTTHNYEGSMEDDIKNKETELVVEEECLYVIPKKNKAKRWSNKIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INJ1</accession>
    <name>A0ABM5INJ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="4 13">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_028137370.2">
        <property type="nucleotide sequence ID" value="XM_028281569.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281569.2">
        <property type="protein sequence ID" value="XP_028137370.2"/>
        <property type="gene ID" value="LOC114331880"/>
    </dbReference>
    <dbReference type="GeneID" id="114331880"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="14">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137370.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="299" mass="33161" checksum="451987BBED667F74" modified="2025-10-08" version="1">MSMIITGANFENDDNEKYNYETLKETADFLMKSVSIIPKVGIICGSGLGTLADGLDNKVTVPYEDIPNFPKSTVQGHVGALVFGNFGGIPVICMKGRFHYYEGYPLWLCAMPVRVMKLLGITHLIATNAAGGLNPKYKVGDIMLVKDHINYVGFAGNNPLQGPNDERFGPRFPSMSRPYDRELIREAKRIAIGLGLRRDIHEGVYSCLGGPNFETVAELRMLKKFGADAVGMSTVHEVITARHCDLKVLAFSLITNECIVEYDNLAVTNHEEVLDIGKLRQETLQKFVRQIVEFIGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPC4</accession>
    <name>A0ABM5IPC4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 4d2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137988.2">
        <property type="nucleotide sequence ID" value="XM_028282187.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028137989.2">
        <property type="nucleotide sequence ID" value="XM_028282188.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028137990.2">
        <property type="nucleotide sequence ID" value="XM_028282189.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282187.2">
        <property type="protein sequence ID" value="XP_028137988.2"/>
        <property type="gene ID" value="LOC114332393"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282188.2">
        <property type="protein sequence ID" value="XP_028137989.2"/>
        <property type="gene ID" value="LOC114332393"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282189.2">
        <property type="protein sequence ID" value="XP_028137990.2"/>
        <property type="gene ID" value="LOC114332393"/>
    </dbReference>
    <dbReference type="GeneID" id="114332393"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137989.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="58785" checksum="1E23CF259C5C2AE3" modified="2025-10-08" version="1">MLYIILILVILLWFILWILQHGYWNYQRNKYLKQIPGPKPVFLFGNMNFFLFLPREKYFSKLQEFINQYGPMFRAHVGPTIDAVICADVKFAEFILTSSKAMKKSLVYGFLHGWLGKGLLTSTGTKWKQHRRMLTPTFHFSILESYVDIFDRVGDIFIRTLKQQVNTASLNVFPLVTLCTLDIISEAAMGIQINAQESQTSEYVKSVNTMCNIFIGRVTSPIPHFLYRLTPTYYRERKAIRILHDQTDKIIDIKMEERSKNANNQQDQSNQQDQSTRKRLAFLDLLLESSIDSKPLSRLDIREEVDTFMFAGHDTTATAISFALYCLAMNPNAQEQAFIEQTEMFGKNLKTAKPTIHQLQEMKYLEMVIKESLRLYPSVPILGRTISDEEEFTWEGSVFRKGIEVVISIYHMHRNPKYFPDPDKFIPERFEEANKYSSFIFLPFSAGFRNCIGQKFAMLEMKSVISKVLRNFELLPTDPPHEVKIVPNVVIASTNGNHLRLRNRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQX7</accession>
    <name>A0ABM5IQX7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139165.2">
        <property type="nucleotide sequence ID" value="XM_028283364.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283364.2">
        <property type="protein sequence ID" value="XP_028139165.2"/>
        <property type="gene ID" value="LOC114333479"/>
    </dbReference>
    <dbReference type="GeneID" id="114333479"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139165.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="30314" checksum="C8F17D97603DB61E" modified="2025-10-08" version="1">MSLTDVENELLVDWLGEMLKNEGRYVEPILETKSIMLVRETCNIIKQDLHVFAYSVDILELYLKEKKSRYEDVDDHCLTLIATVFLCTKFIGNQDTTMHIFLRMLKKFTGQKYSREVVISKEIDIFETLGKKLPINNSVDDLKTFVMKFEKESRIRGSILNISCEILEILYLTRQTWFFSLKNVYSFNQEALEVFKMLMQNRFFLPIGIMIYALKNTSYNNILDVDNILKDLSRGSSIHEDHLNTLISQIDSVVKNSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUY2</accession>
    <name>A0ABM5IUY2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142988.2">
        <property type="nucleotide sequence ID" value="XM_028287187.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287187.2">
        <property type="protein sequence ID" value="XP_028142988.2"/>
        <property type="gene ID" value="LOC114336807"/>
    </dbReference>
    <dbReference type="GeneID" id="114336807"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045667371" evidence="1">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142988.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="204" mass="22399" checksum="DBEF53077C1474B8" modified="2025-10-08" version="1">MFKIASLILIISIIAPLVIGGQDSAIEWRPFNGLPDDRAIVIQIQTEYTPTIYIGLAHVIDDVAQSEAYLPVNLVEGFDYANVTLNDKSYLVKENLQILCFKNPTYLSWKWTKAENFDDLLNDPTFAPIVAGWEANSILGYNATVYMGVGDIPALGGNNVGKVYHGLPETDNGRKDGGLYIDRTGVSAEYTIGGGRFLVPVNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0G0</accession>
    <name>A0ABM5J0G0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155602.2">
        <property type="nucleotide sequence ID" value="XM_028299801.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299801.2">
        <property type="protein sequence ID" value="XP_028155602.2"/>
        <property type="gene ID" value="LOC114349428"/>
    </dbReference>
    <dbReference type="GeneID" id="114349428"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046531385" description="Cathepsin L1-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="294"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155602.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55881" checksum="A01A24BC50E620B8" modified="2025-10-08" version="1">MMKLLIFLVCIVAVNCLNDIKHWNDFKVKFEKSYGDQNEESQRFEIFQGKLREIEEHNARFNNGEETYTKGINQFSDMTHEEYIEMLSYSKELRPARSQHVTLRTFPREVLADLPDFVDWREKNVVTEVKNQEACGSCWAFSTTGGLEGQYALKYNKLVSLSEQNLLDCSGPYGNGNCSVGGIMRFGLDYVKDNGINTEETYPYEAVQKECRYQPSQNVLRISGYDVFEQSEEALQYAVATYGPISVAIDFSLAGGYASGIFNNPACHNKPEELNHGVLVVGYGRENGIDYWIGAVTSVKDQGSCGSCWAFSAIGGLEGQYALKYNKLVSLSEQNLVDCAGPYGNGDCNAGGIMSRGFDYIKDNGINTEEDYPYDGQIFGCRYQPSKNVLHLSGYQQIEPSEDALKYAVATYGPITVSIDASTAMLYEDGILNNSSCENRPDKLNHGVLVVGYGTEDGTDYWIIKNSWGTYYGENGYFRLIRNANNQCGIIDDASRPLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH50</accession>
    <name>A0ABM5JH50_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050497266.1">
        <property type="nucleotide sequence ID" value="XM_050641309.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641309.1">
        <property type="protein sequence ID" value="XP_050497266.1"/>
        <property type="gene ID" value="LOC114333918"/>
    </dbReference>
    <dbReference type="GeneID" id="114333918"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="403" mass="45892" checksum="A4FAF65807DD7EEC" modified="2025-10-08" version="1">MLSSLVLRLQDPMIYTLYGFAIFFLVFWCALWIIHLLAIFYGKYRLHRKVKPLSTDEPYPGVSILKPLMGTDAHLVSNLETFFTMNYPMYEILFCVEDAKDPAIDVVNALLKKYPNVQAEVFIGGSNVGVNPKINNMNQAYEASSYDLILISDSGIRMKEDTLLDMVEHLTEKTGIVHQMPFTSDFRPGFAATLEKIYFGTAQSRMYLGADLLGVNCHTGMSTLMRKTVLEDQGGLKKFGCYLAEDFFIAKSFLDNGWKTAISSQPALQNSGICDVNSFQARLTRWAKLRVAMLPTVIILEPLSECMVIGACAAWAASLLFRWEPLVFYLIHILVWFLCDWMLLSIIQNGSLPFKRFDFIIGWLFRELSGPYLFLVALCHPEIKWRNRVFKLTWGGMAQEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKT7</accession>
    <name>A0ABM5JKT7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498554.1">
        <property type="nucleotide sequence ID" value="XM_050642597.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642597.1">
        <property type="protein sequence ID" value="XP_050498554.1"/>
        <property type="gene ID" value="LOC126879515"/>
    </dbReference>
    <dbReference type="GeneID" id="126879515"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="109" mass="12671" checksum="1FEA18645AAB1BB0" modified="2025-10-08" version="1">MTNYYYLDISLVFPYSSDLEITPVYFKKSIMDAGYQLFGQTFTSVDVDLLKYNEKEKRAVLRVPQSHYVKLRSSLSFVHTYADEKCYFRVHKASPLLLSLQGDSRSCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLJ1</accession>
    <name>A0ABM5JLJ1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498812.1">
        <property type="nucleotide sequence ID" value="XM_050642855.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642855.1">
        <property type="protein sequence ID" value="XP_050498812.1"/>
        <property type="gene ID" value="LOC114327453"/>
    </dbReference>
    <dbReference type="GeneID" id="114327453"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045704466" evidence="1">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="222" mass="24877" checksum="BC9768FA3FD3767E" modified="2025-10-08" version="1">MAKVVKILFLMFSVCLFIQEGFPLTCLKCSSSDVNGNCRTGSRPRRGSWSRQVCRSDTAKCFAVASVNDYGQPHFQRGCTRSNNICQEREDVDIAFCLTCKSLHCNYDYMLLNPGLEEFLNVVNNNQIREENSTPASLTTTSTVSVTNPPHVYKTTKSPLADTKTSRLNAMNVKPESKDELQENLPEDGFFEFGKRIPTQPSSKTSDVTFFDDAFTLSAKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQU2</accession>
    <name>A0ABM5JQU2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500307.1">
        <property type="nucleotide sequence ID" value="XM_050644350.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500308.1">
        <property type="nucleotide sequence ID" value="XM_050644351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500309.1">
        <property type="nucleotide sequence ID" value="XM_050644352.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500310.1">
        <property type="nucleotide sequence ID" value="XM_050644353.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500311.1">
        <property type="nucleotide sequence ID" value="XM_050644354.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644350.1">
        <property type="protein sequence ID" value="XP_050500307.1"/>
        <property type="gene ID" value="LOC114335389"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644351.1">
        <property type="protein sequence ID" value="XP_050500308.1"/>
        <property type="gene ID" value="LOC114335389"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644352.1">
        <property type="protein sequence ID" value="XP_050500309.1"/>
        <property type="gene ID" value="LOC114335389"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644353.1">
        <property type="protein sequence ID" value="XP_050500310.1"/>
        <property type="gene ID" value="LOC114335389"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644354.1">
        <property type="protein sequence ID" value="XP_050500311.1"/>
        <property type="gene ID" value="LOC114335389"/>
    </dbReference>
    <dbReference type="GeneID" id="114335389"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="515"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="693" mass="76620" checksum="D2BA5AA0F37627AC" modified="2025-10-08" version="1">MSVPGTPEIRIQRPLYENDQLRQDLNYEKDQTNFVNKLCKEKVSPKSIIKSTIPVLGWLPKYEWRTDILSDLASGYTVAIMHIPQGMAYALLGNVPPVVGIYMAIFPVLVYFFLGTSRHVSMGTFSIACLMTGKAVLEHADPSYFDTTNTNSTDVVIRGMGYSPVQVATTVTFIVSIIQLLMFALRLGAATNLLSDMLVSAFTCGSAFQIVVTQIKDLLGITMPKIKGNFLTIKILKVIFEEIGQTNYAAVIISAITIVVLIFNNEFLKQLVAKKSSIPIPIELIVVIIGTVSSQYLDFHKNYGIKIVGDIPTGFPQPEMPPLDLVPSVLVDGVSTAIVSYAISMSLAMILAQKANYEVDANQELLAMGVSNAVGSFFSCMPLCASLSRSMIQQVVGGKTQIVSIVSSMLLIVTVLWIAPFFESLPKAVLAGIIVVSLKGMLVQVTQLVSYYKLSKFDALVWITTFVSVVFISMEIALMVGISLSLLSIFIASFKPYTCLLGSVPHTDLYLDMNRYKGAKEIEGLKIFHYCGGINFATKGIFKTELYRLINLNPQKELISREKLDKIMNKDLPPTEFKEKVKKLESKINRDLKCIILDFSSVSCLDPCSVTMLRNEMAEFKKLDITFYVAACSDDIYNLLNKCGLLSKEKESLRVFPSIHDAVQAASHAMNIPIELQILPIVLPNIMIENEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT82</accession>
    <name>A0ABM5JT82_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501147.1">
        <property type="nucleotide sequence ID" value="XM_050645190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645190.1">
        <property type="protein sequence ID" value="XP_050501147.1"/>
        <property type="gene ID" value="LOC126881129"/>
    </dbReference>
    <dbReference type="GeneID" id="126881129"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="258" mass="29980" checksum="29B928E82EBAFCAA" modified="2025-10-08" version="1">MENNNSKKTNTHNSGDGNSKKYKFYRKPPVRKTIPEVKQTKTSIARLLKANPLLKYENSEIKDNLSVQARTNNYSNKILPIKDNIRPGTQVTTKQDIPRKTLSSLHIEKRKKEFYETSKRGKISNGMKKPLKSILKRRSRSLENFDTKGCYRITEEEDRNGLKEADSQSMHNLSQLYQEPSPLDNGFHISFEFPSLAEMRENVSTPLKKEYDEENKENIEVNILECDSYNDLHIPNDNVDFRKSKELGEHKDKNCNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU90</accession>
    <name>A0ABM5JU90_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050501505.1">
        <property type="nucleotide sequence ID" value="XM_050645548.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645548.1">
        <property type="protein sequence ID" value="XP_050501505.1"/>
        <property type="gene ID" value="LOC114339383"/>
    </dbReference>
    <dbReference type="GeneID" id="114339383"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044974094" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="48"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="564" mass="64035" checksum="2CBFF0CD46E3F7EC" modified="2025-10-08" version="1">MNVIIMLLVKLFFIVFVFYQTVETKASLLDVSNLDEDELIVTLLKPSSKIRGHRLMTRLGQDYYAFQDIPYAQAPIGKNRFKPAIASEGWPDILDATSNKKKCFQPGSPVPFDTLIETEDCLLVNVYTPVKPGTRPYLPVYFWIHGGGFNTGNGAIGTLDPRNFMDYDVIVVTINYRLGVLGFLSTDDESIPGNLGLKDQQFALKWTYDNIKAFGGDPKKITIGGESAGASSVSYHLLHTGNKDLIKGIIQESGSALNTFAYQINCTENAFTYARLLDQTFASNSSQDLLELLQKTPAETLIETQSNMHSGELLGFMSGDYWKPIIESDSNTDAYVTGPMQENFMQGNFLRVPSFVGFNSEESLTFLMAATEDQYEKSVKQFDEHPELMISNKLNTIGNEVKDVVHDWKKIYTDVPFAQNKAAFVKYSSDAGYIHPLTRQAELTSQFAPVYMYQFAYGEPFLNVSGTEHVGHAEELMYLWNLPFLPVGIDEQFRTILIKFWTNFITYQNPTPHYDDIIYWPKVDPENLEYLNINETLEIRTGPRNYLEVKNIRERCIIEPYTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUM0</accession>
    <name>A0ABM5JUM0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501635.1">
        <property type="nucleotide sequence ID" value="XM_050645678.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645678.1">
        <property type="protein sequence ID" value="XP_050501635.1"/>
        <property type="gene ID" value="LOC126881413"/>
    </dbReference>
    <dbReference type="GeneID" id="126881413"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="46744" checksum="37CB31432893B8A6" modified="2025-10-08" version="1">MEVKQGICDEFKQIEVKQEVSDETCRAEIYAVDDGNLDIGKIEIKEEVKRESIHDTFDYVALEKSPIKTEIEQEEHKLTSCKERQTNLREFPQEKNTLEIIKTIDIQLSNLLAQEKTLKSEICGKRFVRKEYLNQHLDIHSAEKPYKCEICFRQFSQDGNLKKHLRVHSREKPYKCEICSKRFTRNAKLIKHLRIHTGENPHKCEICFKQLSEAGTLKKHLQIHREQQYQCEICSKKFSEARTLESHLRIHTREKPYKCEICSKQFSRNDYLKNHLRIHTGEKPYKCEICSKQFSQAIYLKNHLIVHTGEKPYKCKICSKQFFHHASLKKHLIIHTGEKPYKCEICSKQFSQAIHLKNHLRVHTGEKPYKCEICSKQFSEAGSLKKHLRTHTGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWU0</accession>
    <name>A0ABM5JWU0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502405.1">
        <property type="nucleotide sequence ID" value="XM_050646448.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646448.1">
        <property type="protein sequence ID" value="XP_050502405.1"/>
        <property type="gene ID" value="LOC126881838"/>
    </dbReference>
    <dbReference type="GeneID" id="126881838"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29976" checksum="4657F3CF707BA539" modified="2025-10-08" version="1">MSNLIPESNLQTLKCALCNNYLSVPPIMTISRDAQRHKCGRCQLIPSDMSVRNTLYENLAQLSTFPCTFPDCEETLKWGEVEAHEKVCLYKTLRCPVSWKCNDQVSIKDLTNHCMRYHGKNVSQNQIVATVEETTEKNKITIMLLVHKEKPFLVFRIVTSDNIWIKVFSLTPVENCYYELSINSDASTCSLFYKNPVEVYIESRHCKKCTMNECDNKLHKKYKKKIDDAAADNGFHKVTKEMVAELNMKEIRCRIVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXZ1</accession>
    <name>A0ABM5JXZ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502806.1">
        <property type="nucleotide sequence ID" value="XM_050646849.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646849.1">
        <property type="protein sequence ID" value="XP_050502806.1"/>
        <property type="gene ID" value="LOC114327435"/>
    </dbReference>
    <dbReference type="GeneID" id="114327435"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1280" mass="144413" checksum="77E5792CC45D05DC" modified="2025-10-08" version="1">MGELSVNGNNPEKDQDENITDKDLPLSFVESRHTEPIVGIDCITHMWRMKERMKTVSVALVLCLNVGVDPPDVVKTQPCARLECWIDPTTMSSSKALEKIGQSLQTQYERWQPRARYKQSLDPTSDEVKKLCTSLRRNAKEERVLFHYNGHGVPKPTSNGEIWVFNRTYTQYIPLSIYDLQTWMGAPSIYVYDCSNAGIIVESFKQFANQHESEYQQNVNQQTKLANNQPPSFKNCIQLAACSSDQVLPMNPDLPADLFTACLTTPIKVALRWYVLQPTSKLMPKVDLELIDKIPGQITDRRTMLGELNWIFTAITDTIAWNTLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSCDCTPVSSPPLPPTFQHPMWNAWDLALDLSLGQLPGIINKEEPFEHLPFFEEQLTAFQVWLELGSEERNPPEQLPIVLQVLLSQVHRMRALELLGKFLDLGPWAVNLALSVGIFPYVLKLLQSCAKELRTLLVFIWAKILAVDNTCQSDLVRDNGHKYFLSVLQDTSISAESRTQATFVLACIVNNYHDGQEAALQGSLVSVCLEQLNDPSPQLRQWVAICLGRLWDHYEKARWTGVRDIAHEKLYNLLKDPVSEVRAAAVYALGTFINSVMERSEHANNVDNAVVMTLVNTVSGDMSFLVRKELVNALQWVVLAFEPLFVNLAVKEQTSISPGQDCILSSGGMRRMGSRDRLKIGDYDSMERMKRVSSSSAINNISHQGMTTSYSGSLSTLSSLSYGSVYMKIWSALSSLENDPHPEVAQMCSTVTGHIRTLVKEQWETVDRVNSLNSSSLSLPPSPNKGNYFTESPPTLHPAGDLQKLTRSTIASRTRKLHRNVISEESEDKMQFCRKPLVNTKFVEWSSKRFAQSNKKEKNFRDKECTSYYERDWRHSRNDSIRTEATEEHRKALASRVESQVFHIRTAVPPSLLQLHPFDQQIAVAGNDSFAIFDWGTGAKTTSGQNRSSKVVNSKITSMEWINSHDIGMLMVASDDGGIKLWKPNTGTSREPSLITAWQAFSELKPKYSGIEMTWEQWTQTLITAGDSRVIRFWDAERELKAFDIPTGTDSSVTCIDSTFSSICHENYKKHYSGFEVNDDGLLLNGAKSYHGPKLGMCVIGFVDGSIRLFDRRCNPNDARVKVWLEHPGSVLTVQLRENIVISGSTSGDVRIFDIRKSDSIHTTQAVPSYGMSCMSIHRFANTYACGSMNQFISIYTLKGTPLNTIRVYEGFMSHKIGPVTCLNYHPHKVALATGTSDCCVNVYSLEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZJ7</accession>
    <name>A0ABM5JZJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503364.1">
        <property type="nucleotide sequence ID" value="XM_050647407.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647407.1">
        <property type="protein sequence ID" value="XP_050503364.1"/>
        <property type="gene ID" value="LOC114325558"/>
    </dbReference>
    <dbReference type="GeneID" id="114325558"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="470" mass="52338" checksum="E6E2828EACE26E4C" modified="2025-10-08" version="1">MKLFDFSKFKSRIFQYLAALAANLGMLSIGLHYGWPSSAISVLKSGEYSFKMTEEEISWMIAVTPMGSVIGDVIAGFSMNIFGRKKMIWFSAIPLTVSWILIAVANSSGYLFAGRIIAGIVDGLLFTAIPPYLAEISDPEIRGFLGTTYLVTLVFGMLMSNVMLYFISIPAQAYIAGSVTLVMMIILPFLPESPYFYLLRSEVALAKESLQKFRGKGEVDDEIGRISKGIMEEEKYAKGGLKELFLKPQYRNCLFLALSMTSLQQLSGILGIQSYCQEVFQETSDIIDPKVANLIYYLLYFLATLVALVLIDISGRKPLVLFSSVVVCITLFTISAYSYIKNSTHIDLSGYEYIQIVAILVYICAYSIGLNCVPILVSSEIFPSHIKSKAFCVINLCYSVVSTSVVKYFSWSASTFSLAVPFFTFAIFSFASVIILSIFLPETKGKTLEDVQLQMRSNKLKKLEKNNYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K040</accession>
    <name>A0ABM5K040_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503554.1">
        <property type="nucleotide sequence ID" value="XM_050647597.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647597.1">
        <property type="protein sequence ID" value="XP_050503554.1"/>
        <property type="gene ID" value="LOC126882623"/>
    </dbReference>
    <dbReference type="GeneID" id="126882623"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="67139" checksum="69680C5656E409FE" modified="2025-10-08" version="1">MPESKETKESERLRKNRESVRNRLDTFAKYIDKIAIPGSSDNLPVTELSVRLDRAETIIEEFEVVQGKIDALVDDVSVEIKYHEDFENVYFSTIAKAKELLQPKPIISSNENANQSSVSDRNSSCNSGIKLPTLHLGQFSGNYSTWLDYHDCFDTIIVKNNDISDIQKFHYLKSSLSGTAEKIINSIKVSAANFTVAWKLLCDRYSNEPLLIHNHIKSIFNLKVVNRDSSKCLQHLIDGLTSNLRSLESLGEPVSTWDSIIIFIILEKLDPETVKDWDKESRGNAPTSVKPTLDDLLKFLQHRADTLEKFEARSIKGGSSSKDHSHSSSHRSKTHISQSFINNGASSDLCPHCNGPHKMSTCTSFQNLDVHARMREVKRVRACFNCLFIGHQNTSCKYGKCKKCGKKHHTLLHVNAENSNSPNDTQSVSSDNQTPQTLSCHAVQNSFALLSTVTVQILDRSGVKHNCRALLDSGSQSHFVTYSLVSKLGLSKEPADISVVGVTQISSRIKHKKQSRAPSVSLGNWPTKERKGTVSRDKPGETQETIRLVMALKIFTCDGIWPTNRGCYQDLPLASRDERQPGKTQGISPSIPQRPTLLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1A6</accession>
    <name>A0ABM5K1A6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fas apoptotic inhibitory molecule 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503972.1">
        <property type="nucleotide sequence ID" value="XM_050648015.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648015.1">
        <property type="protein sequence ID" value="XP_050503972.1"/>
        <property type="gene ID" value="LOC126882939"/>
    </dbReference>
    <dbReference type="GeneID" id="126882939"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010695">
        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088:SF3">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE FAIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22094" checksum="000DB69D7E3F0D12" modified="2025-10-08" version="1">MLSTSLSLEKADSIDRSDLVAYWSVPLLDGVHTVEFEHGTTSGKRVIRVDGNEIVRRDWMFKLVGDEEFYIGKQEAKCLLKVDPIPHFAFSYSLEIDGKPLEKFTEKQSQSIRSWAVITEGKRYRIVFEKQTLNIYVNGEQVEAESNFVTNGTEMSFIMGNTSATIRAETTQKKEGVVHQLFVDGKCIEEDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2I2</accession>
    <name>A0ABM5K2I2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504398.1">
        <property type="nucleotide sequence ID" value="XM_050648441.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648441.1">
        <property type="protein sequence ID" value="XP_050504398.1"/>
        <property type="gene ID" value="LOC126883193"/>
    </dbReference>
    <dbReference type="GeneID" id="126883193"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31372" checksum="49D5ADB1738378D3" modified="2025-10-08" version="1">MAENQAGSHVLANMATVSAPSEFNFSLPGSWNQWKKRLERYMSKQRKLTQFNLTPAQQVYSIIIEKFDAHFIPQKNVIFERFKFNTRSQQPGESVDAYITALHSLAEHCSYGALKDELIRDRIVVGVLDVKVSERLQLQKNLTLGEAVLTVRQAELQNSQNRILRQERVQEVATVNAHRGNYWSQSQAEPNKYGQQNTWGKSNKNYKCTYCSVPSCNSRERCPAKDSRCRLCGKKGHWQARCRSGRNVRVVEGQNCAESEVGIENEMENLQVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2Q8</accession>
    <name>A0ABM5K2Q8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504471.1">
        <property type="nucleotide sequence ID" value="XM_050648514.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648514.1">
        <property type="protein sequence ID" value="XP_050504471.1"/>
        <property type="gene ID" value="LOC126883234"/>
    </dbReference>
    <dbReference type="GeneID" id="126883234"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="697" mass="80389" checksum="2DEA7844B535EFC8" modified="2025-10-08" version="1">MASCSKQQENNYSEMDREDSLERVKKITRMELYTIIKDFKGNKIEEKFSLLEERVAQLTLCPSERRSVLTRSLKYFKTSFKKRWSAARNTDRRFLENNMEWLNVSLELPTWTHKAGRPTKEFGELCDRSKRRRTKDLRHRVPFDELTYAASVSHGTAGNVDVSKVMKEITSTPTRAKKFRKAISSAKKEPIAGKYTPQEALALFIEGNFTRRQWELIQGGRKEIYPCYSILQKAKKECYPAEDSIQVTETSFEVELQALLNHTTLRLLQYLTEVIDTLSEFEKQHLTLISKWGCDGSNQTQFKQKFANTDDDDANIFLSSLVPVRMVVFVNGETRKIVWQNPVPSSVRFCRPIRARFIHETKDITKEEISYIEQQARNLKETTGMEDSVKINHTILFTMVDGKVCNAATDTASTMRCYICGQTSKDFNKLERGNVCEESLRFGLSILHARIRFFELLLHLAYKAPLQKWQARTAEEKHVLKETKQKIPKSFKEEMGLLVDIPKVGYGNSNDGNTSRRFFNDPECSSRITGINLDLIKRFQIILEVISSGYDIDPSKFDYFAHTTAKLYVELYGWHPMSPTVHKILTHGAQVISSHIVPIGQLSEEAAEARNKHFRKYRVDFARKFSRVDCNRDVLNRLLLTSDPFISCSRINRKKKSKSFSQEAISMLLTKIVNCDSSNDEDDENQITCELGDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2X0</accession>
    <name>A0ABM5K2X0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504535.1">
        <property type="nucleotide sequence ID" value="XM_050648578.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648578.1">
        <property type="protein sequence ID" value="XP_050504535.1"/>
        <property type="gene ID" value="LOC126883263"/>
    </dbReference>
    <dbReference type="GeneID" id="126883263"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="20010" checksum="9252A4123BCACB63" modified="2025-10-08" version="1">MYKHLSKHKIMIRHSLEVTCLMTIGDLVAQCIVDKKPISQINLNRTLKFGSLGFILVGPCMSAWYKFLTVSVNAKDPRAPIKKMLMDQLIFAPSMLPIVMTAVGMYVNNYTWKKTKNEIRNKYFDILITNYQVWPIVQLVNFKYVPYKYQVLVAQCVGIFWNSYLSWKTVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4L5</accession>
    <name>A0ABM5K4L5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505130.1">
        <property type="nucleotide sequence ID" value="XM_050649173.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649173.1">
        <property type="protein sequence ID" value="XP_050505130.1"/>
        <property type="gene ID" value="LOC126883533"/>
    </dbReference>
    <dbReference type="GeneID" id="126883533"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="187" mass="22223" checksum="A941051BA54D2DF0" modified="2025-10-08" version="1">MSPEEEKEEKRLTKETEAWDSSKEEMSPEEEEIRIEKEGERDTIETVVFEEEVCEKEEAEYTINMCKESEEKGRKLICGKEKEKELRVKLREYENLINEENKVAKKYEHSFEVKDVGNFRSKTYPIPYKYRHWDKGSNCFSGGNKYFDIKENCCCREKIILFVALIENDFISKQGGVVIVYQSINQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4W8</accession>
    <name>A0ABM5K4W8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505232.1">
        <property type="nucleotide sequence ID" value="XM_050649275.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649275.1">
        <property type="protein sequence ID" value="XP_050505232.1"/>
        <property type="gene ID" value="LOC126883623"/>
    </dbReference>
    <dbReference type="GeneID" id="126883623"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="264" mass="30229" checksum="11E662C40C1C90BE" modified="2025-10-08" version="1">MMMMLLHDTETWTLKADMINRLETFEMWLYRRMLSIPWTAMQINEAVLHRANVVHTAYILEVRDIIVSPPATERYEKLKSELIKRLSASQQQKIKRLLEHEELGDRRPSQFLRHLQSLAGTTVPENIVRSLWLGRLPASTQAILATQAKASLDAVAELADTISEAIAPRAHISEVSNALESTIEKLTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRGRPYPRDRSYSRERNSDICWYHYRFGDQAQKCSPPCKHQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4Z4</accession>
    <name>A0ABM5K4Z4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505254.1">
        <property type="nucleotide sequence ID" value="XM_050649297.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649297.1">
        <property type="protein sequence ID" value="XP_050505254.1"/>
        <property type="gene ID" value="LOC126883641"/>
    </dbReference>
    <dbReference type="GeneID" id="126883641"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="34165" checksum="08CE69EEE5FF3B4C" modified="2025-10-08" version="1">MLKNKKQGYEEFEEAKDMIRNHFKDGAALWFESKQNELQDWEEFERKFLRYYWGKEKQMVVNSELQNGKYDEKLGISEEKYALQVYASGQYLNYNYSEEQLVELIARHFDNTMEDYVTLQGYRDMDSLCQFLVVREARRKERRTGRQTENNGNNQTNRTNNYRQSRNENPYRYNGHRDNEGQRYTNNFNQNRYEQNRNGYHQNRFQNNGRKYNNQPYQPNAGRENFNRGNQYNNNNGQGREQNREINSLSFIKEGENEQGHQEMDNMEVEINRAGSSFQEGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5S7</accession>
    <name>A0ABM5K5S7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050505528.1">
        <property type="nucleotide sequence ID" value="XM_050649571.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505529.1">
        <property type="nucleotide sequence ID" value="XM_050649572.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505530.1">
        <property type="nucleotide sequence ID" value="XM_050649573.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649571.1">
        <property type="protein sequence ID" value="XP_050505528.1"/>
        <property type="gene ID" value="LOC114328149"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649572.1">
        <property type="protein sequence ID" value="XP_050505529.1"/>
        <property type="gene ID" value="LOC114328149"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649573.1">
        <property type="protein sequence ID" value="XP_050505530.1"/>
        <property type="gene ID" value="LOC114328149"/>
    </dbReference>
    <dbReference type="GeneID" id="114328149"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="688" mass="78481" checksum="10B28D364ED6F885" modified="2025-10-08" version="1">MDKYEVIGTLGEGSFGRVYKAKELSSGSFVALKVISKRGRSARELKGFRRECEIQRDLHHPNIIQMLDSFETENEIVVITEFAHKELTAILGRVGYLPEDKVQKIVWDLVSALYYLHSNRVLHRDLKPQNILLDMNNTAKLCDFGFARNMSTGTHVLTSIKGTPLYMAPELIDEQPYDYTADLWSLGCIIYELLMGSPPFCTPSILHLIRLIRHEQIQWPTFLSDSCISFLKGLLQKNPTKRLKWDEILDHPFVKDHINITENTSPESLTVPLSPSVLHAKEQQRRESMKNKATRIPAKSNEHSSASKPVTSKTSKNSQENSADALKKSSNQDSQNNNVLEDSTKSRTSNINVKDSSLESSFQNINLNTSKSKNADGESQRSQEKSPLKTFSFIEDNQPIETEEWIVFLTRTIQEVINGEMISLTQSTQTNVLVSPLRNPNASPKVLSFVARLLSIPFVVKGVSTDCLLQIRKVYLEVKLVPNLVYATKLLLRECRTDLSSDTASPINSPSPLSAEVYKRSADLTEEDFQTLEYIFILVDHLIHLDDDFLIQFCDAVVILSIYLLMKLFVSFTYKTKIRVVTDILAILTRLMSRLPENSDVVERTLLAQSEDQDVNQINFIDLLRHSDALVRERTCYFLLWFGKTQQMKTIKMFWNFEVKDTLEALVYDSMEAVRNVSHFCYTQSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K955</accession>
    <name>A0ABM5K955_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506720.1">
        <property type="nucleotide sequence ID" value="XM_050650763.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650763.1">
        <property type="protein sequence ID" value="XP_050506720.1"/>
        <property type="gene ID" value="LOC126884691"/>
    </dbReference>
    <dbReference type="GeneID" id="126884691"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="298" mass="34357" checksum="D62771E5F6357873" modified="2025-10-08" version="1">MIFLICYSLSVEEESNSSVPFLDTLVVRTDSNLICLDWYRKNTNSGRFIPYNSYHPEKQKINVVLAMKNRITNICHPKFVDKNVKILYDTLLSNQYPKKLLNKLLFSNHIVNNDANRSVDQVDIPVRYGKLPFLQNLTRSLIGLFSGFNIKIATYNLKTLNLFYSRLKDPTPTLQRCNVVYGIPCECGLVYIGQTGQRLNKRLSLHKSDCKLKPQSTSLSIHVNSKDHRVLYNDAFILDVSDKDFQRKILEMCYIYNAKNSINHKKDVDNLSTIYTFLLKQNISGTKKLPAIYVSDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCF6</accession>
    <name>A0ABM5KCF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507873.1">
        <property type="nucleotide sequence ID" value="XM_050651916.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651916.1">
        <property type="protein sequence ID" value="XP_050507873.1"/>
        <property type="gene ID" value="LOC126885359"/>
    </dbReference>
    <dbReference type="GeneID" id="126885359"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF323">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045549870" description="Peptidase metallopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="9">
        <location>
            <begin position="85"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="347" mass="40167" checksum="93C802156E163C7F" modified="2025-10-08" version="1">MMEVFFMCMLLLRFIAATDAFSEDDAMRFFHQYGYIENGSLADFNTTLLHFQERYNLYVDGTLNDDTIALMQKPRCQTGENDYSLTGKWYKHNLRWYFPQADRAHHIIQIVERAFKMWKDVSNLHFSRVTLPVPTPDITITAVKGKHYFRSNCMGNRECGQQFDGRGGKLAHAYFSLINDTCVEIHVDLDEKWSYNVNDTDYDSANLFMVILHEIGHSLGLSHSNDKNAVMYPWYSHKLLTITQDDINGMEALYGRKSTYITTQQTSASTQATPRKSTSYIPTQASTSTRSHKSRVHTTRPRPIPTEIIPHQTTKTAPSFCAIEYPNILFLAYDPQFKNHHMYIIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCP4</accession>
    <name>A0ABM5KCP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507963.1">
        <property type="nucleotide sequence ID" value="XM_050652006.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652006.1">
        <property type="protein sequence ID" value="XP_050507963.1"/>
        <property type="gene ID" value="LOC126885436"/>
    </dbReference>
    <dbReference type="GeneID" id="126885436"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55966" checksum="CF7FF5B471822057" modified="2025-10-08" version="1">MSRPAHLNHEKRISAFAQTRNTHNPTWTPFNKYDKEKKQDHLKPKANILLEPDVKLNDNIDNDSQPLNKTLDLYEFQENDLEEKASKSPEYDKLEEKTYTPLKAVNFDCYPILTKIDTNLNTDHRDYEDNEDFSESRDTSSYVPETEIESEGGEEETIIPIFKTINVTCPESTLTKDEPSEKPHISNIETNNSIVALSHRKNRVWDRKNFCPICFVEVSHFARHLERNHADESRVKKSLSFPKGSNEKKTLWDSLRKEGNFHLFREEKKVVAVGRPTEAQALDFDDFVACENCSGVYKKKFFYKHAKKCQDKHTGTKCGRLNALTQSQTFLAASRCQNSFLSQSRLKKEVFCIMKADKISATAKNDILICLFGETHLKKHKRKQIVTVTSNKMRQLARLLIALREFTPVQNLIDAMKPELFDDLVTATKVISGFSNADKSFKSSSLALHMGTTLKQVCDIINRMILKKSPLFTFKNPNEEKKAFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE19</accession>
    <name>A0ABM5KE19_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508446.1">
        <property type="nucleotide sequence ID" value="XM_050652489.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652489.1">
        <property type="protein sequence ID" value="XP_050508446.1"/>
        <property type="gene ID" value="LOC114331190"/>
    </dbReference>
    <dbReference type="GeneID" id="114331190"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="258" mass="29581" checksum="297F6BD87C32EF5C" modified="2025-10-08" version="1">MKYITTMSTTTTIEIGDEGVSKITEDLGNYLAKTDFFGETFLWNILDNVSLVTWWKGFCGHSCLSKVAVRILTMPCTSAATERSFSSQSSIHTKRRNRLTTQRAANLNYIQYNSKLLKRSRQHHIQSQYPIEETVQNNVSIEGRNLQKEIEVIENHISEEEELDETISSWHSNTTGNGNSDDDFNFADFAMTDDEIDQRMETREQRPARILRQSKVNILENVLMKSGKGTEQPQKKTEVEKDTSDAENKVVRSVYIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KES0</accession>
    <name>A0ABM5KES0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508684.1">
        <property type="nucleotide sequence ID" value="XM_050652727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508685.1">
        <property type="nucleotide sequence ID" value="XM_050652728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050508686.1">
        <property type="nucleotide sequence ID" value="XM_050652729.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652727.1">
        <property type="protein sequence ID" value="XP_050508684.1"/>
        <property type="gene ID" value="LOC114326167"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652728.1">
        <property type="protein sequence ID" value="XP_050508685.1"/>
        <property type="gene ID" value="LOC114326167"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652729.1">
        <property type="protein sequence ID" value="XP_050508686.1"/>
        <property type="gene ID" value="LOC114326167"/>
    </dbReference>
    <dbReference type="GeneID" id="114326167"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="369" mass="43131" checksum="68F41BDE061AFAC6" modified="2025-10-08" version="1">MLVDESVQTSRKMERKAFEERVIKEGMDLWKKQREFELRRKLQEQREIRQMMDTYWPWGKGTDARPRGLRNLRLEELFPNKDYINNKRYVGSLGLTNKAGGGGAPIFSDGKKITRTCEDPMLRFQFGSKDLRKCVDNTLRYKTNKQQQEEYKKELDKLVEEKKQKEKQEKKESVHFHQEQGWSDEKTLKHLENETIKSNIHDNKKLNGSNKHLTSHITHSKPSSRLDPIAYPKRNFIPVGRNRKLSPLSENKDEGVELVALLAKDRKYPLKIPLCSSDVTSEKKMGNNLKPGIWSRQGSAYLKALAEQMMYKQHKTQEMKAKEEENSKKHFSTWSGFWGRPGNGAPLPEIRKQCLDDMLYPKMTPIGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF52</accession>
    <name>A0ABM5KF52_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508815.1">
        <property type="nucleotide sequence ID" value="XM_050652858.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652858.1">
        <property type="protein sequence ID" value="XP_050508815.1"/>
        <property type="gene ID" value="LOC126886021"/>
    </dbReference>
    <dbReference type="GeneID" id="126886021"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045469041" description="C2H2-type domain-containing protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="609" mass="71260" checksum="E52D1548CB42C9BC" modified="2025-10-08" version="1">MILLIVCFLVEYFYSDFTVWGKIIIEIHKIKCNQMEVKQEIREETCKVEVVYNDLDDALLDSFECKIEEEPSRQSTQDTYSYLEVQEHPVNPKIEQHGNKLNSYEGNQKTEKGYIQDEHKMEITETLIEHSSYEGNYVSPHAAGTALSQNMKIATGKRPHKCEICLKQFSHLSFLKTHLRVHTGEKPHKCEICLKRFIQAGNLKRHSRTHTGEKPYKCKICFMQFSETSVLTRHLRIHTGEKPYKCEICSKQFSLAKSLQTHLRVHTGEKPYTCETCLKQFSEKNHMKSHLRVHTGEKPYTCEICCKKFSHACSLKGHLRVHNGDTPYKCEICFKQFSHASSLKGHLRVHTGDTPYKCEICFKQFREKGNLNRHFRLHTGAKPHLCEICLMQFSQKSQLESHLRVHIGEKPYKCDICFKTFSQNGQLKVHSRLHTEGKPSTSEICFKQFTQRSILKRHLKVHTGEKPHKCEICFKQFSQTCNLKIHLRVHTKEKPYKCEICFKQFSQAGHLKEHTRIHTGEKPYKCDICFNHFRRPSLLKRHLRVHTGEKQHKCEICFKQFSQAGHLKEHTRLHTGEKPYKCDICFSLFSQASALKHHMRSHTGEKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF92</accession>
    <name>A0ABM5KF92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508872.1">
        <property type="nucleotide sequence ID" value="XM_050652915.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652915.1">
        <property type="protein sequence ID" value="XP_050508872.1"/>
        <property type="gene ID" value="LOC126886072"/>
    </dbReference>
    <dbReference type="GeneID" id="126886072"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="86148" checksum="A8398C9ABF5FD896" modified="2025-10-08" version="1">MEDLKKKRTPLKAKITRIENWLSQKASTEKDALQFQFRQTELKTCFLKYEEIMDQIDEIDEAGTEAEDRVTTEQKYFSILAGLQRKMDELLLGPPPLRSNSTQSTVATAKVRLPEITMQTFCGSFSEFNSFYQLFETLIVNNEELNNVQRFIYLKSFLRNEPLQLIDNIEVIDENFDIAVKTLKDRYENKSRVISLHIQKLLKAPSLVKSNSKALREFLTLAQQTLLALKNMSVPIEHWDLLLIEIFLQKLDFSTHRAFEYDIGTKTLPTLSQFFKFLEKKCDIQEKLNVSDHDKKVNNRSQSKTSFFSSVDQPSHSFSDNNCTFCRSNAHKVYQCNDFKCLSLQEKFNFVKGKKLCFNCLGSKHFSQDCGSTRSCTLCGGHHHSSLHGTSENVSSSRNINRQALSRERNAQTPQNSQGASRVVAPISTQHSFNNRSQNEASTSSSRPPLDMQNSPDSQAATSLSALSVKTDVLLATALLQISTISENTSLSNEMLNLEFFPYNVKDRSFKTSFAVLDSITCRLPRATIDRSKIKVPQDLTLADPSYSVPGKIDLLLAGDIYSELLTDGFIRLGKNLPILQNTHLGYVIFGTINPQVFHRNSHLAISQSNVSLFVQSEPEENQLDKLLQQFFEIEEVPLVSKLTPDEELAEQIFSKTTLVLPSGRFQVNLPFVSENANKMLGDHDRDEEVEISQVQEVPDLTFEEFMTDNGGTGKARHDVTTKEKQDLLALPDPTLAHNIPASIKEKKFLWTKIQYVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHK8</accession>
    <name>A0ABM5KHK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="10">3.1.3.57</ecNumber>
            <ecNumber evidence="2">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="10"/>
    <dbReference type="EC" id="3.1.3.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050509618.1">
        <property type="nucleotide sequence ID" value="XM_050653661.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653661.1">
        <property type="protein sequence ID" value="XP_050509618.1"/>
        <property type="gene ID" value="LOC126886674"/>
    </dbReference>
    <dbReference type="GeneID" id="126886674"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0452">Lithium</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="324" mass="35162" checksum="A3DE08A59530F1E8" modified="2025-10-08" version="1">MILIKGISKFVTMSCQSAPLILRLLASSVTTARRAGSIIKDVMEKGELGIIHKGLSKNDVQTEADRSAQQCIITSLARQFPNVTIIGEEGPLDESEVPSDWIVTESDQNILQRKCPENYVNVKPEDIVVWVDPLDGTSEYTEGLLDHVTVLIGIAVSGRAVGGVIYQPYYEYKTVKNGPGRTFWGLVGLGVGGFEPIKPPSNKFVITTSRSHRDGKVNDALKALNPDDIISVGGAGHKVIVVLEGRAHAYVYASRGCKKWDTCAPEAVLEAAGGRLTDIHGKHYDYSKNVSFPDDQGIFATASGVDHDALIAKLPQELRDAFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ29</accession>
    <name>A0ABM5KJ29_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510103.1">
        <property type="nucleotide sequence ID" value="XM_050654146.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654146.1">
        <property type="protein sequence ID" value="XP_050510103.1"/>
        <property type="gene ID" value="LOC126886958"/>
    </dbReference>
    <dbReference type="GeneID" id="126886958"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="134" mass="15405" checksum="683721D3C883C89A" modified="2025-10-08" version="1">MENKGSHFSSLEKDIILDLAIKYKCIIENKQTDGVTNKQKAIAWENISKEFNAMNVNTHRTSKQIKTFYENIKRKIKKKQAIEKVEKYKTGGGPEETTTVLLPGEERLVGALKEQFKPGQNVYDSSTSFYEGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ40</accession>
    <name>A0ABM5KJ40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510225.1">
        <property type="nucleotide sequence ID" value="XM_050654268.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654268.1">
        <property type="protein sequence ID" value="XP_050510225.1"/>
        <property type="gene ID" value="LOC126886995"/>
    </dbReference>
    <dbReference type="GeneID" id="126886995"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF17">
        <property type="entry name" value="BEAT VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="315" mass="35688" checksum="B1180D359814CBF2" modified="2025-10-08" version="1">MQTTIHHKMAKEIIKQYGTVFLAIVLFCVKGCWTLKEMRIGVPEAALSGDTVTLACEYNLEEVALYSIKWYWNDEEFYRYVPKESPPFRAFTVTFADFNVDIVRSGPTEVTLRNISREMTGDYKCEVSADAPLFHTDIQSAHMTVIDPPKSNPRLIIEEPPEPTIKIEIGKSVRAGCSAPWGPTSQLPPNITWFLNDEQIKPDHPTAQILPTKTEFNRTAQQKVSISKLEMTTTKSHFARGLLKIKCKVSFYSIWNKTMEMFFKEDSPQLASVLGSTSSQSHTDQVIEIITSSSCRSISVSKVLFLFIVTTIFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJY3</accession>
    <name>A0ABM5KJY3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 12</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510516.1">
        <property type="nucleotide sequence ID" value="XM_050654559.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654559.1">
        <property type="protein sequence ID" value="XP_050510516.1"/>
        <property type="gene ID" value="LOC126887175"/>
    </dbReference>
    <dbReference type="GeneID" id="126887175"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="86341" checksum="E60AA548E0605E96" modified="2025-10-08" version="1">MPGPVRPKGSNTGSRAQSVAPMSERQQMALLMQMTSGNELGSRSPSSSSSRTRERNERGETPLHLAAIKGDVDQVCKLLAQHTDPNVADFAGWTPLHEACNHGWYEVAFRLVQSGANVNARGLDNDTPLHDAAVNGHLKLVKLLVEKGADIYAKNSKGKTPLDVAPASVKPYLLNSALPLPDSTSNSRVVSRASRDDKKITSSCDPSTSTASTASGGSNAAGGNSGAAASTSGKAQKNEPMEVKTSTASGTFSATAGTSSRNTSGTARGASGTTTGDDVYEFKSAKEGDTSSAERKQGSGSGSTEMETDETDPLSVTRPTTQASEESSSSSAKRPFYDGNEGQEESVAPANTGDEETKRKKRKEDNAREGKSTNQRNAGQNKGQGGKQSTGGQTRSGASTSSKASADKKSPCSSPKPPGSDPEVEDGKTDLKVPPLKIVIPQTSNAEQESGAGRNGKNSSQRSHLPYVVPSSTNTEEKDSSATTNSPESSANTSKSEDKKENSGATSDEAQSNADAETSSSSASTSAPPPPAPPQVELHPRKRKMKQNKDVPPPPSDSQESSAETQVHPHEQPITNCYRLYLNIRQQIAKRRRGLFPVQPKPPQGFKDYLMNRCTYVLAGTAPTTPNITYPQTLPPQMKDLFTDQEKERYRLRTQHVIEKEKLVLSVEQEILRVHGRAARALANQSLPFSVCTILRDEEVYNLITPEQEEKDRNARSRYNGRLFLSWLQDVDDKWEKIKEHMLLRHHNEAESLHAVQKMDWEWKLKELSLCDRKSTPKIDETHVPMVHVSDDFDLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KME9</accession>
    <name>A0ABM5KME9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein dopey-1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511369.1">
        <property type="nucleotide sequence ID" value="XM_050655412.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655412.1">
        <property type="protein sequence ID" value="XP_050511369.1"/>
        <property type="gene ID" value="LOC114327250"/>
    </dbReference>
    <dbReference type="GeneID" id="114327250"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="7">
        <location>
            <begin position="1349"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="6">
        <location>
            <begin position="1888"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="571"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2405" mass="273844" checksum="366BBBFFDCEA6D05" modified="2025-10-08" version="1">MTTVAMEEYELMKDSKYRLYVAAIDKALKNFEYTSEWADLISALGKLNKVLLSYTKFPVIPRRIKISKRLAQCMHPALPSGVHLKALDTYDIIFRCMGTNRLACELFIYSAGLFPLMGHAAMNIRPTLLTIYETHFIPLGDRLRPALSGFLSGILLGLDTGTDHFDRTNLLLENVCEGVESPYFYTCIWQCVANNSPVRLPAISYVLAHYSRKLSMEDQLFLMGNDIGLMVSGLSAAVQDSSVLVQRSALDLLMVCFPMNNQQLLYADMVRLVTAALTTILRRDMSLNRRLYSWLLGSEINNLLALQSENELEEEPAPEQHILAYDLLNDALKIILKKCSTETPIDIKPYRLLISLFDKPQIGTVILDNILCDVFRTLYLSCWYQQKNKNSAIRCVSFTGDLTSLKNEENVLSKQFVIKNCPELIKNANLLFNTLQRHYIWSYIEKLFVEAVRNIKTYKYRDRNQVSEIGSGPPHILELCILTDFLLDIIPIESYTENTNNILPNLFWKLVSTVKSNVADLNQHEISESLQLCTKILSKIQPDTLMQNTSVQNQSLDITLNDLSEKTLENSVNLEDSTENGETRILEKSKSDSKINENLNNFSKNELTVGENNRERSYSNQMLKKKEKTSPRIDKKSKNKKSKSTSRLDESKNEADDSMSSENNTPVPDKRPLTVIETVEPLPKIAKVENKHFIKCLEEYKSFYTHFIKVKLLPNTDIKSVVQSLTCDKDSRTVRLVTLLGARLQENYKCDFNPIDISNFITKNKILSLSNATSRKSESDYERAMGIASNILLEFSAFPNLLIAEEESKLPTWVESLIVVACCKDSSRENQLTAMNTLLEIFSLANNSICSRKIDCNTNILITGILDVIYVKYIEENTVVIEEMCQILWKLLGTLSNQNQLMLCVTLLYQIHNIFDNTMFVENVINTYLTHENINVLAIKQFFLLWHLGRDLNIKTSPNKPNIRNFDRSLLKILDNLQNKETPNLQLISESFLTHSLLHNDIARIINPILLKLLASNTARVSIRHVNIADSDSQSDITKDEHTRMDNIQSKKIYAVSNVNGNIMYHVTDSPSPRPSKKRWFTFSKAGKRYSSSVINMTTSINEDSNNVVTRKNRDFKGVTNSPKSEKTPKNVKLIINPLSSKEIYPTGLDGSYTKRDSNSSLESISSSNESPTSYDDSLSKCYTPERLTNGERDSGFDSLKNKSSLELSNDRDYRAILESIEPIADGVVEAVNDGVNVTKIPKSQSFDEHINAAKTTDMESSLVQSWSYCISDSDNLHASSELEISKSAEDFFRKNEEKIIVGEILNEIIDRVCSEYIDDDIDGAAIRPTDLDLRKMNQQTPKNVALYPIHSHLCLYYEIFDSNQIIYGLQTLKNCINSNPQLFIKCLATSGIKDLKSNEILNLLARHRKSLLGYGFTGDLSNDYVNFYRGYMFLDVIIIICLNYSRTFFPFLDDSSLITEEMNNNLKIQLESLDILNIIMKKLIIMVAENSKGFSSYIADLLVKCKLQKILLNCLLISVRNFDDEMTFAEEILAYNNFQLCDNNNRIGEHVEAYQLQILRLINSLIILEHKVFSRKGSGESSTNGEVNSSIVLIPQQQIFLSAVMSALRQQSIKYLHENWLYMITSCLPYFGDNLKQISISVIHQICDNVEKIATNYNMPELENELCSDYAVTQLEALTMLCHYCLLDSSQTVNQNVPTNSTTPLTNPGEIINNLFNVFFSPLGSDINFSSKQNSDHYQSARKTILSHMPRIISSVAKLWQTIVNLENDYNGVYGNSKIVKQQLLEFLSPISVHHSTSFLAAISVAWYERRNPFSSVKTVLPEPNASQNNLVYLILAIRVIPLDNLVQTVTAVIKNPPPTEGLSQDICLDVSVLELFYCYMRNASSTQLFEAWGSLLALIREGCSLAPPAQFLLAAILHEIMIKCCPLEEKKDQKDLQDVTAKLIDCVSQVCGSCLEQTTWLRRNFAVKEQDEDSTPDSNIISDTFVNSNHNVQAQLLLSEILAPILDICFGSSEKDKVNNILISLMCNIVPYLKTHTVKNMPSFGACSKLLSSLSSYQYTRKAWKKDVFDLLLDNTLFQMEYSCMKYWRIIVDNLMTHDNTTFRDLMNRVSMNQSGSLNIFSSREQEYEQKAQLLKRLAYVIFCSEMDQYAKYMPDIQEQLTSSLRLSVPGVQAQVFMCFRVILIRMSPLHVTSLWPIIISEMLQVFLQIEQELSTDTEEFSSHIKLMSSLDASWATNSSNGLHALGHPHWLRLQLATAKLLDLTLLLPATTLPQFQMYRWAFVGDDLNKKANTQLNQIPFSPHVVRIAELMDKKYPETHIDYLPMNRNELLLTMNSITQLKDLHGFFKTLRTCSDRHRTDCSKFSATDHLYNSERQTDKHLETVLEKIDKVVEMDFLDRIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNP2</accession>
    <name>A0ABM5KNP2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511793.1">
        <property type="nucleotide sequence ID" value="XM_050655836.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655836.1">
        <property type="protein sequence ID" value="XP_050511793.1"/>
        <property type="gene ID" value="LOC126887912"/>
    </dbReference>
    <dbReference type="GeneID" id="126887912"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047004107" description="TIL domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="2">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="119" mass="13107" checksum="EED64BC50394650F" modified="2025-10-08" version="1">MKSYLTLTVILVAVFYVEAQETTTTPPNTPLTPPPGSTLAPGGITWKNCTRPNEYYTCGSACQTTCATLGQTCPIVNIRCNDDCYCIEGYARDAENNCIPIKDCPKRRPCQSTCKRCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KS89</accession>
    <name>A0ABM5KS89_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513051.1">
        <property type="nucleotide sequence ID" value="XM_050657094.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657094.1">
        <property type="protein sequence ID" value="XP_050513051.1"/>
        <property type="gene ID" value="LOC126888712"/>
    </dbReference>
    <dbReference type="GeneID" id="126888712"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="263"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="386" mass="44936" checksum="7FDB3CD4D37D28DA" modified="2025-10-08" version="1">MASSSSTSSSFTPVLLRTVSKSVYSPREKTIVLNVHDALVFQNPTNTVRNIIESCANTTLVAALTIYRFLSERKKQGITNLNTNEHLKRGKSLLKLMNLPKILFEGKFTDFFFKKEIPNLNKILQEVKDDPDLPNIGRTKLWEVLKELNFRWEKSDRKSVLIDREEIICWRRHYLRSIRKFRAEGRPIYYQDETWVNAGHTLTKIWSDKNILSSRQAFIEGWSTSISPPSGKDSRLIISHLGSEKGFLRDGLLEFQSKSTKDYHEEMTADVFEEYFEQMIEHIPPNSIIVLDNAPYHSRLVERLPTTAWKKQDVLDCLRNKSLTYEDGMVKAELLKIARQHKSKYKKYVVDKMAERRNITVLRLPPYHCEINPIKLICAQNERLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSC4</accession>
    <name>A0ABM5KSC4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513097.1">
        <property type="nucleotide sequence ID" value="XM_050657140.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657140.1">
        <property type="protein sequence ID" value="XP_050513097.1"/>
        <property type="gene ID" value="LOC114349389"/>
    </dbReference>
    <dbReference type="GeneID" id="114349389"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF9">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="115"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64814" checksum="03A356F5F4C3B63B" modified="2025-10-08" version="1">MNKKNSSTMAMKEWVRRMQPFQLYVVLGLTIAFFLLELIVSHLTHALTLLMDSYHTLCNIMALGGCILTIKYGKDTPKQVFEMKKAPSESESIGEELTSNPAKCHDHKKTKASVTRSNQEKKLKNTFGWARTDVIFMLICCVFLASLSFSIFVEACQTLVHIDHHDEMHHSISVLCLGACGLLLNGVCYLLIGGYTFHQGSFLYVTESGNVVLSKIVVDQSLQQGARRLSRSKTIHPMIGHQKQRQGFWEMARDVNGCILVVICALLVYFTDKDTAKYIDPIMAIISSTLIMFLSYPYMKESCLILLQTMPDTIDIDTLKIQLLNHFPDIVNIHDFHIWQLTAHRVISTVHIIFQNPKVYKQLIEEVKEFFNDYGITQVTIQPEFFKKNASMDSLNSKYAPNCLVACLEDGCKDNHCCPSYKDKSITKSHSKEVIPGNTTPDLKSVKILNDELAHLHNGSVSNINLNLPAENKQSTPVHNCDSNVTSIPQLPTEQKQQDTTTSSEDSLSASKNESISESENKVTSTTSIPLEIANEDTGDNSTKDSNSKIICNDVTSKEEETGANSEVKEVITDLNTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KTW3</accession>
    <name>A0ABM5KTW3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513630.1">
        <property type="nucleotide sequence ID" value="XM_050657673.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657673.1">
        <property type="protein sequence ID" value="XP_050513630.1"/>
        <property type="gene ID" value="LOC114333391"/>
    </dbReference>
    <dbReference type="GeneID" id="114333391"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="101" mass="12005" checksum="4CF425626A21D2E6" modified="2025-10-08" version="1">MCFIYFHFVDWSDYTPSKLKQPVAKELKEKKGKVTGSTRNAKWCKVAEAKLELYRLKKQALIADHNRKKDLHDLQVKYLKEEHDLKMSLLRGKQQPQTKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUK4</accession>
    <name>A0ABM5KUK4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513864.1">
        <property type="nucleotide sequence ID" value="XM_050657907.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050513871.1">
        <property type="nucleotide sequence ID" value="XM_050657914.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657907.1">
        <property type="protein sequence ID" value="XP_050513864.1"/>
        <property type="gene ID" value="LOC114333209"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657914.1">
        <property type="protein sequence ID" value="XP_050513871.1"/>
        <property type="gene ID" value="LOC114333209"/>
    </dbReference>
    <dbReference type="GeneID" id="114333209"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="539" mass="64532" checksum="E5EE5D88A8B8A564" modified="2025-10-08" version="1">MEIKQETSEKTCKIETNNETCDNSLDVFNLEIKEEPKRECEYQIFDYLDPNEFHVKTEVEQDEHKFTLFEEKQTSEESCSQEENRMKIMETLHSSHEEKDTGQHSDEKILNKNMIVATGQQSYKCEICFKQFNQTNSLKRHLKVHTRKKQRCEICFKQFIQAASLKTHLRVHTGEKPYECEICFRQFSQSGGLKKHLRVHTGEMPYKCEICFKQFSHAFSLKIHLQKHTGEKPYKCEICLKRFNQSNTLKTHLRVHTGEKPYKCEICFKRFNQSYNLKKHLRVHTEEKPYKCEICFKRFNQSDDLKKHLRVHTGEKPYKCEICLKRFSQACSLKIHLQMHTGEKHYKCEICFKRFNQSNNLKKHLRVHTGEKPYKCEICFKRFNQSNDLKKHLRVHTEEKPYKCEICFKRFNQSDDLKKHLRVHTGEKPYKCEICLKRFSQACSLKIHLQMHTGEKHYKCEICFKRFNQSNNLKKHLRVHTGEKPYKCEICFKGFNQSNDLKTHLRIHTGEKPYKCEVCFQQFTQASSLKKHLKIHTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWN0</accession>
    <name>A0ABM5KWN0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514596.1">
        <property type="nucleotide sequence ID" value="XM_050658639.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658639.1">
        <property type="protein sequence ID" value="XP_050514596.1"/>
        <property type="gene ID" value="LOC126889915"/>
    </dbReference>
    <dbReference type="GeneID" id="126889915"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="214" mass="24810" checksum="F542EA02B40B3530" modified="2025-10-08" version="1">MDTLNYGKTILRDMMTRVIPRNLFGGPLRNMPISEFRKRKLLYVFHVFFDVNQSGTIDRKDFELAIDKICSLRGWANGTPQYKKTFDDMITIWEGLKFKADANKDGQVSVEEWATMWDEFSKTPENALEWQTQYMRFMFEMEDSSGDGAIDVDEFTGVCSCYGLDPAECKLAFQKMAQGQPSVSYEQFEVLWKQFFTSENPSDPGNFIFGKTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXS3</accession>
    <name>A0ABM5KXS3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514977.1">
        <property type="nucleotide sequence ID" value="XM_050659020.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659020.1">
        <property type="protein sequence ID" value="XP_050514977.1"/>
        <property type="gene ID" value="LOC126890167"/>
    </dbReference>
    <dbReference type="GeneID" id="126890167"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051004">
        <property type="entry name" value="DC-SIGN_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802:SF465">
        <property type="entry name" value="AT17652P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22802">
        <property type="entry name" value="C-TYPE LECTIN SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045548535" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="184" mass="21323" checksum="16A8E115CF7673DD" modified="2025-10-08" version="1">MSTFLSWVIKVFLVCLFVWTQVSGDTSSVLYTSHVKPPKSPNIFNYAGKIYYFSTTIKANFYAAHHFCRQQGMQLLTINSDAENHKISEFATQIGQGAQREDFWTSGTDLAKPKFFIWLSNGNPFTYQRWSPAEPTGLGRRDGKDYVENCVQLQRDSSLHDFSWNDRYCLDEMNFICEKYDNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXW7</accession>
    <name>A0ABM5KXW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515036.1">
        <property type="nucleotide sequence ID" value="XM_050659079.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659079.1">
        <property type="protein sequence ID" value="XP_050515036.1"/>
        <property type="gene ID" value="LOC126890225"/>
    </dbReference>
    <dbReference type="GeneID" id="126890225"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="739" mass="83783" checksum="0CB8CB3004C91DA5" modified="2025-10-08" version="1">MNKTVDDLTKAKDDLVKARDSSKAWITILENWLKDNGNKNISKNELISRKDYLSKVFDKYLDVQNELEILDDAYAVDMADVEGRFLILESALNDKIDQISVNSVMSTSAQQSPTNSNNRHVHLPEIKIPHFDGTIENWPIFSEMFTKLIVNDTHLSDIEKLIYLKSILKNEPLQLIENLEIVGSNFSIAIDILKNRFENKCLIINTYLKQLLNVPSITKNTAQNLREFLTHIKKNLSTINNLNISDNLADFILIHIFTRKLDFNMKRSFESERDFNELPTIDEFLDFIEKKCKILENLIFEEKTNHKPKPSLYTSADNRDTLFKCFVCNSSSHKVYSCQKILNLTAQERIQKVKNKGFCLNCLASGHISNICPSLSNCKTCNRRRHSLLHISHPSENNAKQVSGRLNHQSPPAQNQFVRNFRDQRQNQHPSQCTSENIQANSQNNFVLNAIPQYLPDMQNPPGPSNISSHSVYSKNLQVLLATALVTVYDVQNNPISVRCLTDSGSQVSFITDRLAKRICYSPYTRNLQISGIAQTSSVSNKMVDLQIHLNTSPGKNFYLSCAILESITCQHPRVALDLNLLKIPKNVKLTDPHFCTPSDVDILLGADIYFDLVTYGLIKLGPNLPILQNIHLGYIVGGNIPYSRNAMLGSNSNPSTNVHSHYSNVSLHAQTADLDSLLKNFWEIEETKPINPIHAKTLTPSEQQAEDIFKSSFTILPSGRFQVDLPLKTPSEYRKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXX6</accession>
    <name>A0ABM5KXX6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515048.1">
        <property type="nucleotide sequence ID" value="XM_050659091.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659091.1">
        <property type="protein sequence ID" value="XP_050515048.1"/>
        <property type="gene ID" value="LOC126890237"/>
    </dbReference>
    <dbReference type="GeneID" id="126890237"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50529" checksum="4ACC8D351D418240" modified="2025-10-08" version="1">MASFKAEHLLSSELDYELKIRQLADPSLTTDQAKRVVFTGALKQASANRSHAVPSAFPLNFADEVREIEVTLADLKAQISSFVGSHSDVVYGRLTSRLGHVSGRVHLLESVNEEEDAIKKSLNFKILNLEGELEYKVVPQAHSTPHNPSVSVNSFPFFKSAPIHKWGVCFSGSSDENVVSFLEKVECLRIARGNTEDECFSSAGDLFKDSAFTWYLNNRGGFTSWQQLVAKLKSDFLHYNYEDTLLDDIKSRKQSPQQKVTIFINEIVSLCKRLEVPLSESHIVRIIKKNLLPSYHSSLALTDIPSIADLTEKCKKLEEVLSWSSDTLVPSRSNFKNNEPSYSGRPNYSRSGNQGHGYYDCHEPRIRFCYGCGRQGVRKFECQFCSGNERRGGSSLAAAPHQDTGNTTETHQNHGTNSSSLEAQASTSQSSHPLPKDKRPQNGKRQPKRGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ65</accession>
    <name>A0ABM5KZ65_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 SUMO-protein ligase PIAS2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515480.1">
        <property type="nucleotide sequence ID" value="XM_050659523.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659523.1">
        <property type="protein sequence ID" value="XP_050515480.1"/>
        <property type="gene ID" value="LOC126890522"/>
    </dbReference>
    <dbReference type="GeneID" id="126890522"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF94">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="12">
        <location>
            <begin position="535"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="731"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="866"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115429" checksum="A58F682296E8FD44" modified="2025-10-08" version="1">MSKSAQFYELLKDERENSKLNCVSVNKVKYELLIDKVKTVKIKSNKDGNDYRFLKRYDVIEVNGITKLISPVTEQDSIKYFICDEDLFQILNDAHITTGHGGRDRMVKHLKTKYKNITYKDISIFLSLCEPCLQKQKSLKKGIVVKPLLFKELNHRCQVDLIDFQSQPDGEYKFILVYQDHLTKFVVLRALKSKTADEVCENIIDIFTLLGAPTVLQSDNGREFVNKIINGLVDFWPNFKIVHGKPRHSQSQGSVERANQDVENMLTIWMHDHKSSNWSYGLKFIQLMKNSALHSGIKRTPYEAMFGCPPKHGLATSSIPTEALTNVESEEDLEAVIRDITVSGEHDTGENIQETSSTLENEGDLSVTENSEDQHLEGTSYLLTDLDKSTMDIKRQRDEAFKCLTDQAKRMKSTSDHKLQPVDKGCTVRVPVPDVDRGRGDARSILGVVLDVVDNGFYRIGTRDGVLKQLYARQEISNGSSGTPVSSMPQQDNDQTIVQSHSVGGRQMSSAAQPTMSMYQTNMYSHYPEYSQNKQQPNVAYPIHPDVKFRKLPFYDVLAEILKPSTLVPSNNQRLQEAQFRFSLSPQQSSDIANSRDTRPGTTCDYIKQVQLRFCLLETSCEQQDAFPPCISVRVNNKICPLPNPIPTNKPGVEPKRPPRPVNITAMVKLSPTIGNHLSISWATDLTRGYALSVSLVQKLSSVELLQRLKSRGSKNAEYTRSLIKEKLNDDGDEIATTSLRVSLMCPLGKLRMTTPCRPITCMHLQCFDAYLFLQMNEKKPTWNCPVCDKPALYDDLRIDGYFTEVLNSPLLASNCNEIQLNKDGTWCVQTNEKLTAKLDQTTVINIDDSQEVIYDVSDVEIIPISSDSTDADPTNSSTTKLESTVKPEESRKRDIVDLTCSSSEDEEPAPKVRAISPKPDSASISSSSNQSRPITTIDLFSVSSLSYPLSPVIINLDSPSPPCSPPPTPRPQPVTEQIDVSSMIATQADGNTTPSRATTPLDSSNNASIQVLENDTSQNLTDISTALLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZJ6</accession>
    <name>A0ABM5KZJ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515613.1">
        <property type="nucleotide sequence ID" value="XM_050659656.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659656.1">
        <property type="protein sequence ID" value="XP_050515613.1"/>
        <property type="gene ID" value="LOC114335411"/>
    </dbReference>
    <dbReference type="GeneID" id="114335411"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="122" mass="14036" checksum="CD399A378DF84AEF" modified="2025-10-08" version="1">MQVVMIPDPSVPYESWKRATLRLDSLECMVPELFGLPPLPENCFTKLISAKDPKDKVDFMEKDEYKGQKMKAEFSKKKVSVKEEPKINGDSDVMKANRSQESDPNFAESDEELIDETNYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1B7</accession>
    <name>A0ABM5L1B7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516231.1">
        <property type="nucleotide sequence ID" value="XM_050660274.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660274.1">
        <property type="protein sequence ID" value="XP_050516231.1"/>
        <property type="gene ID" value="LOC126891098"/>
    </dbReference>
    <dbReference type="GeneID" id="126891098"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="292"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="442" mass="50849" checksum="3198CA1AF2F22FB8" modified="2025-10-08" version="1">MEKHDDNVCLSLQRIDPLCKIVSCVVVNDSQYSVELKTNFSGDCESACNDWLRKYSTETKTDWIVNRTYPKLTRIAFRKDFVCHHSKRNKSIDTSRLRNRNFDCSASLVVRVRKNTVDTTKRDVLMKEVFNAIIKIEAHHNHAVHVAEAYSYLRMSEDTKADFLKYFNEGLTPAAAKIYHETCLIASSSEEEDVTKMLADGHINPLDRSIYHFYDMWRSNHFGDRTKESMIEVIKNKNAYYTENNITVTIKEDPFIVCIVTPLMKRAHQETFSSEIIFVDSTGSCDQAGSYLTFIFGASKIGAIPLGCVIHQSQNEECYKEAFESLKQTIGETGFNGKFPAVIMTDDSAAERKALAATFPQSKLLLCSFHICQAMWRWLWDSKHNIEKSDRKPLMLAFREIVFEKDVTNTDELLNDFLNSSLLLKYPSLKEHIVGLWERKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2D5</accession>
    <name>A0ABM5L2D5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516606.1">
        <property type="nucleotide sequence ID" value="XM_050660649.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660649.1">
        <property type="protein sequence ID" value="XP_050516606.1"/>
        <property type="gene ID" value="LOC126891472"/>
    </dbReference>
    <dbReference type="GeneID" id="126891472"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="368" mass="42353" checksum="C4D3FC0BF410BF03" modified="2025-10-08" version="1">MDPLIQEYEFNDVNNTNNNLGPIFPTIDECADILHMNITRANCVHEMFKYYKDESIVEKNLSVIFEGEMGIDGGGLTKELFNLFFKKIENLYFHGEDCLVPFLSLNRVRKDKSNFTLIGRILEHMLLLTGSIPSKLSKIMLLLIADPLKEIDKNILVEEFYNFLNPCERLILKKAMSNFNSLNNKEKEILTNTFNSFQFYELPSCDEIFEQVASIASNTLVQTPKQFIDTLRLGINVEKYISFWNKCDFGTLLDFQKPTPNKVANCLKAAGDFLTNEESKILHFLEMYVRCLHDEKIGQFVFLVTGSYQMPDSILIEFSTLVGLAQRPTFSTCTNTIHVPMTYSSYQQLKQDFDLCLSSDEAYIYTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2L1</accession>
    <name>A0ABM5L2L1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516670.1">
        <property type="nucleotide sequence ID" value="XM_050660713.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660713.1">
        <property type="protein sequence ID" value="XP_050516670.1"/>
        <property type="gene ID" value="LOC126891536"/>
    </dbReference>
    <dbReference type="GeneID" id="126891536"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="134" mass="16068" checksum="0F5C2E3591B50296" modified="2025-10-08" version="1">MSQDRRQQQQQQQNQVDPRYPFQNTKEDLRDDLVQDTLNNTNNTSAIPTLQHNDAIDKEELESEEEEAEEENLRMSQDRRQQQQQQQNQVRPSMTPFQNTKEEYCCQIVFEDVYGPYKTTPQHRDGWHLSIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L302</accession>
    <name>A0ABM5L302_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich motor neuron 1 protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516817.1">
        <property type="nucleotide sequence ID" value="XM_050660860.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660860.1">
        <property type="protein sequence ID" value="XP_050516817.1"/>
        <property type="gene ID" value="LOC126891634"/>
    </dbReference>
    <dbReference type="GeneID" id="126891634"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354698" description="Cysteine-rich motor neuron 1 protein-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15263" checksum="A04BF483A5B4DBA0" modified="2025-10-08" version="1">MKHLLLLFAYISFASAVGTNCSTLITHCATEEECKATHCSEPTTVCPKGQVLKELPCKCCPECVPDNCDTNCDAVKCAKPTCPPGQILTPVRCQCCQECAPAYEPNCNLVKCPKLRCVRGRVEIRIPCRCCPVCRPWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6S7</accession>
    <name>A0ABM5L6S7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518145.1">
        <property type="nucleotide sequence ID" value="XM_050662188.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662188.1">
        <property type="protein sequence ID" value="XP_050518145.1"/>
        <property type="gene ID" value="LOC126892610"/>
    </dbReference>
    <dbReference type="GeneID" id="126892610"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17312" checksum="391633AF6AB18990" modified="2025-10-08" version="1">MGKGTRGISVFEHNRQVTVVPRGIWLDRCGFIGGSRDELCVDDAIVKVKCPYKWRESKSLISDMRDKSYIIYINEHNEVVLNTNHDYYHQMQGNLYLTRRRVCHLVISTPSESAIYDVPIEEGSEENIHLLKDFYLNKYIPFLSGNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8W0</accession>
    <name>A0ABM5L8W0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518876.1">
        <property type="nucleotide sequence ID" value="XM_050662919.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662919.1">
        <property type="protein sequence ID" value="XP_050518876.1"/>
        <property type="gene ID" value="LOC126892968"/>
    </dbReference>
    <dbReference type="GeneID" id="126892968"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="666" mass="76653" checksum="E2E5453253B080C4" modified="2025-10-08" version="1">MFYLNKYYIDVNFFRIINNSTFLVNSLSSSKSSSLQNVQALPRLLHRPGTQKYYIILPKNTVSAAVPSQTQLVTSITASPALKVYPSQNQLLMKTKTSSVIPKIRMPSNIKIMMSTNTVGSASPTSMKAIPTKYLLNHPTTLSNVHSNAPVVTQSECASPTYVNPFDYTPDVKNTSSSIGTQKIANVTKNDQNLMQEKVFAWTCKICKQEFHEKELLLEHYEMHKNNTDQLGDIDENNDAYNISGKDVTCPICLTTHINITCYQQHVGSKHKPKDHNCDKCKQAFTDEFDLSVHNTTHNQDLEWYECVICKKFRTKNTKSLYEHIFIEHVKEEMYCNECDKTFLSKTWFEGHKIFHVDINKGDTYKCGRCESTFTSNYSLMEHMQESHTKYKCNQCDVTFPYKLNLDRHNSHVHSYERPFLCNECGKTFTKLTNLRNHEIIHKAGSYVCYVCGKIFKKKEGFDIHMRGHTGERPYKCNFCDKAFAHKSDYNTHNKKKHGERPYPGSDSKKSSFNGSAQKIRMRVQTKEKPYSCFECNKSFSNTSFLTIHMRVHSGEKPYSCSMCKKAFSQSTSLKIHERIHTGERPYPCSVCEKAFINRAALSRHARIHSGEKPYPCSICKKAFSQSTSLQVHMRIHTGERSYPCSKCKKKFITKAMKDKHEKKCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9U5</accession>
    <name>A0ABM5L9U5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein tyrosine phosphatase type IVA 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519214.1">
        <property type="nucleotide sequence ID" value="XM_050663257.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519215.1">
        <property type="nucleotide sequence ID" value="XM_050663258.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663257.1">
        <property type="protein sequence ID" value="XP_050519214.1"/>
        <property type="gene ID" value="LOC114332485"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663258.1">
        <property type="protein sequence ID" value="XP_050519215.1"/>
        <property type="gene ID" value="LOC114332485"/>
    </dbReference>
    <dbReference type="GeneID" id="114332485"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20988" checksum="5A4B4B835457ACDD" modified="2025-10-08" version="1">MNHNSQGQGIPVAMRQKDLRPAAAEIEYKGFKFLITDRPADQTIVGYIQELKKHRVTAVVRVCEPSYKVEELNNQNIEVFDLGYDDGTFPPTKIVDEWFKILKKQFNDNPDCCVAVHCIAGLGRAPVMVALALIELGLKYEEAVELIREKRRGAINAKQLAFLEKYRPKSRLKSKNGHKNSCCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAW8</accession>
    <name>A0ABM5LAW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050519579.1">
        <property type="nucleotide sequence ID" value="XM_050663622.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663622.1">
        <property type="protein sequence ID" value="XP_050519579.1"/>
        <property type="gene ID" value="LOC126893432"/>
    </dbReference>
    <dbReference type="GeneID" id="126893432"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039871">
        <property type="entry name" value="FAM8A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659">
        <property type="entry name" value="AUTOSOMAL HIGHLY CONSERVED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13659:SF5">
        <property type="entry name" value="PROTEIN FAM8A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="119"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="298" mass="34601" checksum="83AED4DCFF678EB7" modified="2025-10-08" version="1">MDDINTISKDQEDYEQLMQKEKKEREEYIEKLKKWLDEARLWHYNVCAGFSYNLGNVRENSFQQFVNPFANLQPQNQPNVLRQRVGFTPNGNYQQPLFQAARQPAQNNQPPPIYEFIIPPLWKRAAAELMDFLLLLLLKVALTFLLLESFDIIDTGYYGLELFHKNLENSDGTVPMAFELLTLELVHRLIVCGYEAYFMQGKFLATPGKRYMGLMVISVQTITPIPSRPTETVSVTNAAPLSWQKSLTRSTLKNLLVGLFLPICIFYIFPQNRTCYDMMSKSLVVEYHPDFMSYHSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EX62</accession>
    <name>A0A6P7EX62_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zingipain-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114324171</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028127724.1">
        <property type="nucleotide sequence ID" value="XM_028271923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EX62"/>
    <dbReference type="EnsemblMetazoa" id="XM_028271923.2">
        <property type="protein sequence ID" value="XP_028127724.1"/>
        <property type="gene ID" value="LOC114324171"/>
    </dbReference>
    <dbReference type="GeneID" id="114324171"/>
    <dbReference type="KEGG" id="dvv:114324171"/>
    <dbReference type="InParanoid" id="A0A6P7EX62"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028319468" evidence="2">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028127724.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26415" checksum="B3594F0CCBD8DBFD" modified="2020-12-02" version="1">MKFLITVFCCCIFKCIANKYSDDLPASFDWRDKGAVLGTPTVPGIFCARSDWAYAIANAVETQLFLTNGTLESFSPQYILDCCSFSDGCNNGPSIERAYACLERNGGVNSQYSYFNGMQGSCFGGANLPIKFERWNHISEEELKRLLVTRGILNVVINGSNLRSYTGGIWLSADCNKSNPDLWTVNLVGYGRENNVDYWILKNWVDSSWGEGGFFRLIRNQNACGITDKVLVPIVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EY75</accession>
    <name>A0A6P7EY75_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114324499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324499</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128154.1">
        <property type="nucleotide sequence ID" value="XM_028272353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EY75"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650162.1">
        <property type="protein sequence ID" value="XP_050506119.1"/>
        <property type="gene ID" value="LOC126884240"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7EY75"/>
    <dbReference type="OrthoDB" id="8190343at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028128154.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32393" checksum="83E509DD06225088" modified="2020-12-02" version="1">MSSARGKWSSQDTISFLEMYEQHRCLWDVHSEGYKDRNTRINAYEAMATAMEIDGFLVEDVKAKIRSLRNAYTLELAKILRSKKLAAGPDDVYKPKLPWFPVADRILNGVVQLREIQPTEIGVADSETQSSVNDVVETVMVDPTPPTAVPGVSTEAIPSTSKRTFTSDTAEPARKKAKTSATNYQRCLDRTLSELKNISASLSKKIAPKEEDEFDMFGKLIACQLKKLPIIVALEAQQYIFSYLIQKRIEHIRRTNRQYDAASPDSAMESSHSDADIPSQEVGSADQADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0R2</accession>
    <name>A0A6P7F0R2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114324808</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128477.1">
        <property type="nucleotide sequence ID" value="XM_028272676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F0R2"/>
    <dbReference type="FunCoup" id="A0A6P7F0R2">
        <property type="interactions" value="2021"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272676.2">
        <property type="protein sequence ID" value="XP_028128477.1"/>
        <property type="gene ID" value="LOC114324808"/>
    </dbReference>
    <dbReference type="GeneID" id="114324808"/>
    <dbReference type="KEGG" id="dvv:114324808"/>
    <dbReference type="CTD" id="136032856"/>
    <dbReference type="InParanoid" id="A0A6P7F0R2"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028128477.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31490" checksum="14AE17499DAFC093" modified="2020-12-02" version="1">MPYANQPSVHITDLTDDNCKFYIEDTDLSVANSIRRVLIAETPTLAIDWVKLEANSTVLSDEFLAHRIGLIPLVSDEVVQRLQYPRDCVCLDFCQECSVEFTLDVKCTDDQTRHVTTADFKSSDPRVIPATSKHRDDESSEYGETDEILIIKLRKGQELKVKAYAKKGFGKEHAKWNPTCGVAFEYDPDNAMRHTLFPKPDEWPKSEYSELEDDQYEAPYNWELKPNKFFYNVEAAGLLKPENIVIMGVAMLKEKLSNLQTQLSHELTPDVLAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F134</accession>
    <name>A0A6P7F134_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane emp24 domain-containing protein eca</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114325227</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129026.1">
        <property type="nucleotide sequence ID" value="XM_028273225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F134"/>
    <dbReference type="FunCoup" id="A0A6P7F134">
        <property type="interactions" value="1085"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273225.2">
        <property type="protein sequence ID" value="XP_028129026.1"/>
        <property type="gene ID" value="LOC114325227"/>
    </dbReference>
    <dbReference type="GeneID" id="114325227"/>
    <dbReference type="KEGG" id="dvv:114325227"/>
    <dbReference type="CTD" id="41177"/>
    <dbReference type="InParanoid" id="A0A6P7F134"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028129026.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25388" checksum="2495364A48C7DA88" modified="2020-12-02" version="1">MGKSVPYFSIAIFFILFEISSALYFHIGETERKCFIEEIPDETNVIVNYKVELYDPRSGGFMPSSTGIGMHVEVRDPDDKIILSRVYSAEGKISFTSHLPGEHVICMFSNSTAWFSGSQLRVHLDIQVGEHAINYGEIVQREKLSELQLRVRQLIDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSITQTAVLLVMGTWQMRHLKTFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F240</accession>
    <name>A0A6P7F240_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pantothenate kinase</fullName>
            <ecNumber evidence="4">2.7.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC114325539</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028129411.1">
        <property type="nucleotide sequence ID" value="XM_028273610.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129412.1">
        <property type="nucleotide sequence ID" value="XM_028273611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F240"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273610.2">
        <property type="protein sequence ID" value="XP_028129411.1"/>
        <property type="gene ID" value="LOC114325539"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273611.2">
        <property type="protein sequence ID" value="XP_028129412.1"/>
        <property type="gene ID" value="LOC114325539"/>
    </dbReference>
    <dbReference type="GeneID" id="114325539"/>
    <dbReference type="KEGG" id="dvv:114325539"/>
    <dbReference type="CTD" id="2091"/>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24122">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF30">
        <property type="entry name" value="FUMBLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028129411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028129412.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45556" checksum="D87615DB48EFE1CA" modified="2020-12-02" version="1">MAPHSCKGCLRDVMAARMSKKNTDPPMEVNGVDEAHTVHNLSMPWFGMDIGGSLCKLVYFEPKELPGTREEAASQVETLMNIRRYLTKNSAYGKTGHRDMHLQMDNVKIRGILGTLHFIRFPTSGMKNFLSLAKYKGMAKLVTTVSATGGGAYKFEEDFRREVNLKLAKFDEFDSLLAGLHYIDRNNPSECYYWANSTDEERCSKVNYDFSRPYPFLIVNIGSGVSVLAVYSETQYKRISGTSIGGGTFLGLCCLLTGCNTFEEAIGLAAEGDNRNVDKLVRDIYGGDYARFGLPGDLVASSFSALCSFGQMNSRERRSNVTKQDLARATLVTITNNIGSIARMCAIQEKIERVVFIGNFLRVNPIAMKLLAYAMDYWSDGTMKALFLEHEGYFGAVGCLLQFHEELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2B3</accession>
    <name>A0A6P7F2B3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114325600</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028129501.1">
        <property type="nucleotide sequence ID" value="XM_028273700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2B3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273700.2">
        <property type="protein sequence ID" value="XP_028129501.1"/>
        <property type="gene ID" value="LOC114325600"/>
    </dbReference>
    <dbReference type="GeneID" id="114325600"/>
    <dbReference type="KEGG" id="dvv:114325600"/>
    <dbReference type="InParanoid" id="A0A6P7F2B3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="149"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="352"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028129501.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="83762" checksum="82C17563BCDF6569" modified="2020-12-02" version="1">MQYNNVYHNNTMFRSRPDRAGDMYNKQQQSNYWCGPPHAMAPIQDFGGPKQQYKKKQKPENNMQLGVPLWQEQDLKPFRKNFYEPHHQSLARTPSDVENYRTRMDIIVRGTDIPQPNFCFEEGKFPEYIMQVLLKQGFNEPTAIQSQGWPVVLSGRDLVGIAQTGSGKTLAYMIPAAVHINHQQRPQRGEGPIALILAPTRELAQQIQKVAHEFGTTTMIRNTCIFGGSPKGPQARDLERGVEIVIATPGRLIDFLEKGTTNLAKCTYLVLDEADRMLDMGFEPQIRKIIQQIRPDRQVLMWSATWPKQVQQLAEEFLENYIQVNVGGLSLSANHNIKQIVEVCDELEKEEKLIRYLKEFGSDRQNKIIIFVETKKKVDDITKVVKREGFSAISMHGDKSQPERDYVLNEFRSGKSSILVATDVAARGLDVEDVKYVINYDYPNSSEDYVHRIGRTGRCQQAGTAYAFFTPNNQRQAKDLIAVLEEAGQVVNPQLLDLAQQAKSTNPKQHRWQNRNKDNSSPSSQNSNKVKTWTNSKSFGEFKPNSGPRITNNMRNDAMQRNQRNNYNNFSHYQNGQVYQQSYSPNSMYQAQQQTQQQSISNGTPRNYGKDYYGASVLFDSDRHYESPKEYHCNNPRQYNNQRYSDRQSYQAPQANMYHTIPAQYMVQSQPADGMQSIMNHKFFQSRGLPGATNPCAYQSMGQGQPTPAYNQFPAGVPYYQYTQPPTAAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F5Z0</accession>
    <name>A0A6P7F5Z0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114325333</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325333</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129183.1">
        <property type="nucleotide sequence ID" value="XM_028273382.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498725.1">
        <property type="nucleotide sequence ID" value="XM_050642768.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498731.1">
        <property type="nucleotide sequence ID" value="XM_050642774.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498736.1">
        <property type="nucleotide sequence ID" value="XM_050642779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F5Z0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642768.1">
        <property type="protein sequence ID" value="XP_050498725.1"/>
        <property type="gene ID" value="LOC114325333"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642774.1">
        <property type="protein sequence ID" value="XP_050498731.1"/>
        <property type="gene ID" value="LOC114325333"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642779.1">
        <property type="protein sequence ID" value="XP_050498736.1"/>
        <property type="gene ID" value="LOC114325333"/>
    </dbReference>
    <dbReference type="GeneID" id="114325333"/>
    <dbReference type="KEGG" id="dvv:114325333"/>
    <dbReference type="InParanoid" id="A0A6P7F5Z0"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129183.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43123" checksum="321610ABBEA17611" modified="2020-12-02" version="1">MSSGLKLLVGCRPAPVPLLSSLFRKNNTKVCHRKMSVLKTKEKQIITPLEEAKRFMIDCFKAVGTNQTHAEIVANNLLEADYRGHYSHGMNRLEMYLKDVKSGLTLPNIVPTIDQETVATAVVNGNNGFGAVVGQYCMNLAIEKAETTGIALVVCHHSNHYGIAGIYALQAIKRGLIGFSATNTSPLMVPTRATKSALGTNPISLGVPANDGDNFVLDMATTAVALGKIEIQRRKGEQIPQGWALNKEGKVETDASVAYKATRLLPLGGEELNSGYKGYGLGMFVEILCGILAGSSYGPNIRNWTDFGKEANLGHAFMAINPKVFAPGVEDRMSDLMNSLRNMEPANPNLPVLAHGDVERQHMEKVHKDGGLSYVQNQHDTNKRLAEKLKISPMISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6F9</accession>
    <name>A0A6P7F6F9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysophospholipid acyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114326306</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130422.1">
        <property type="nucleotide sequence ID" value="XM_028274621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6F9"/>
    <dbReference type="FunCoup" id="A0A6P7F6F9">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274621.2">
        <property type="protein sequence ID" value="XP_028130422.1"/>
        <property type="gene ID" value="LOC114326306"/>
    </dbReference>
    <dbReference type="GeneID" id="114326306"/>
    <dbReference type="KEGG" id="dvv:114326306"/>
    <dbReference type="CTD" id="36045"/>
    <dbReference type="InParanoid" id="A0A6P7F6F9"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028130422.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="56353" checksum="10BDD0C4F9B173B4" modified="2020-12-02" version="1">MSARTSSYQGSQIFAGLAQYAGLETDQLNFLISQIVALLLSTLYRTVLHPSKTRTEIRHAFGLVVGLCMGYFCFGFQAIHLAGLPMICYMIMITQNPHIMHGMVLTVALIYLSCVHLHRQIYDYGSYGLDISGPLMVITQKVISLAFSLHDGLTKQQEEMTHNQKYHAVYKTPNVLEYFSYSLLFPSLMAGPIIFYNDYVDFIEGNNYVKARNSVENSKVVREPSPVKAIIKKVAIALFCAYIFLKFLPRFPIARVKDQHFVENTSISYIFWYLTVSTTLVRFKYYFAWTIADAICNNCGIGFSGYAEDGTDRWDKISNVDIFQFEFATSLKQGIEAWNKGTNIWLRMIVYERTKKFPTVLTYVLSAVWHGFYPGYYLTFLSGAVFTFAARTVRRHVRNYFMTTKEAKLLYDLITFAVTHFVFAYLTFPFVSLEFWSSIVLYNRMYWCLHLGAIAAMIFLPQCVPKSQARELSSKSGIALALRQAGPYSRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8B0</accession>
    <name>A0A6P7F8B0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327365</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131756.1">
        <property type="nucleotide sequence ID" value="XM_028275955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8B0"/>
    <dbReference type="FunCoup" id="A0A6P7F8B0">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275955.2">
        <property type="protein sequence ID" value="XP_028131756.1"/>
        <property type="gene ID" value="LOC114327365"/>
    </dbReference>
    <dbReference type="GeneID" id="114327365"/>
    <dbReference type="KEGG" id="dvv:114327365"/>
    <dbReference type="CTD" id="117366"/>
    <dbReference type="InParanoid" id="A0A6P7F8B0"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028131756.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55977" checksum="8D143B319DD86BC5" modified="2020-12-02" version="1">MSQNTILVFIPDSLDTRLSGYLTGSKRIVKNSEVFYITSDKASNKAYDPLGYIGLLQECDNLNKDVSLLINSTNKEIFLMCEEKHPVTQIVYDFKRFKNSDILYHSAENYGEHFKNLSIELRKHARSVSENGRHFLINILSKVIVVLNVCLNFLSRLNLIVQKSSTFTHFEESLKTMKWFLKTAADQKTVTPKMGNVLIAKPIDIFIGVFLMSYVMQYEDQIFLFVYNTFEGIISSLKGLLLYLMGSPIGLKLNYGFNNFLGQFFLYHISLWRIFLQGAHPIFVSNFKYFMLPGALGFSYQIAMVSDLIAIATFHSYCIYVNAARIFNLQLKCLSSLWRVVIGRKFNPLRNRVDSCQYSHNQLFIGTLSFTILLFLLPTTAMYYVVFSIFRLVTLFIDRLLLGIRTALYNIPVYSIFLWILNTSSVAGNIHITWKSYDEEGNVTIEAKLEKLPFITSIVKFAPDSVSTTTNQRTLRDIFHSTITGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F9V2</accession>
    <name>A0A6P7F9V2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114327816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114327816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132326.1">
        <property type="nucleotide sequence ID" value="XM_028276525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F9V2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276525.2">
        <property type="protein sequence ID" value="XP_028132326.1"/>
        <property type="gene ID" value="LOC114327816"/>
    </dbReference>
    <dbReference type="GeneID" id="114327816"/>
    <dbReference type="KEGG" id="dvv:114327816"/>
    <dbReference type="InParanoid" id="A0A6P7F9V2"/>
    <dbReference type="OrthoDB" id="6740409at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028132326.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18349" checksum="B277BAB881FFE8E5" modified="2020-12-02" version="1">MFELIKNLKPNLSPTAIHCNFEQAAFAAMEDCFPGVNINGCFFHLAQNMKKHVALLGHLTEYNNDTQFALNCKMVTSFAFVPVRHLDQAVDVLGNALPVALQPLLDWFEDNYAGRTNRRGDGRRPPLLPQEMWNLYQRTMKREDRNNNYEEAAHRRLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB94</accession>
    <name>A0A6P7FB94_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein ROP isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328249</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132846.1">
        <property type="nucleotide sequence ID" value="XM_028277045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB94"/>
    <dbReference type="FunCoup" id="A0A6P7FB94">
        <property type="interactions" value="1443"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277045.2">
        <property type="protein sequence ID" value="XP_028132846.1"/>
        <property type="gene ID" value="LOC114328249"/>
    </dbReference>
    <dbReference type="GeneID" id="114328249"/>
    <dbReference type="CTD" id="38493"/>
    <dbReference type="InParanoid" id="A0A6P7FB94"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028132846.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="67440" checksum="074C22C097B61595" modified="2020-12-02" version="1">MALKNQVGQKIMNEVIKHKPTKKNGPTPGQQAHGVEWRILVVDQLAMRMVSACCKMHDISAEGITLVEDIMKKREPLGTMEAVYLITPSEKSVHALMNDFEPPRQMYRGAHVFFTEACPDQLFSTLCHHPVAKFIKTLKEINIAFIPTESQVFSLDSPDTFQCSYDPSFSAARNANMERMAEQIATLCATLGEYPHVRYRTDWERNVELAQLIQQKLDAYKADEPTMGEGPEKARSQLIILDRGFDCVSPLLHELTFQAMAYDLLPIENDVYKYEASAGVMKEVLLDENDELWVDLRHQHIAVVSQSVTKNLKKFTDSKRMTQSDKQSMKDLSTMIKKMPQYQKELSKYATHLHLAEDCMKAYQGYIDKLCKVEQDLAMGTDAEGEKIKDHMRNIVPILLDPKITNEYDKMRIIALYAMTKNGITDENLSKLATHAQIKDKQTIANLQLLGVNVINDGGPRKKQYTVPRKERITEQTYQMSRWTPIIKDIMEDCIDDKLDQKHYPYLSGRAQSTGYHAAPSSARYGQWHKDRGQQAVKNVPRLLVFVVGGISFSEIRCAYEVTNAQKNWEVIIGSSHILTPEDFLSNLATLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBY4</accession>
    <name>A0A6P7FBY4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich venom protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114327823</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132332.1">
        <property type="nucleotide sequence ID" value="XM_028276531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBY4"/>
    <dbReference type="FunCoup" id="A0A6P7FBY4">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276531.2">
        <property type="protein sequence ID" value="XP_028132332.1"/>
        <property type="gene ID" value="LOC114327823"/>
    </dbReference>
    <dbReference type="GeneID" id="114327823"/>
    <dbReference type="KEGG" id="dvv:114327823"/>
    <dbReference type="InParanoid" id="A0A6P7FBY4"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028415113" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028132332.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10711" checksum="9362A936D059E000" modified="2020-12-02" version="1">MKNLVVLIVLSCLSVIAFSAEKIPLCPANSSPGCKPCCPDPSCSNRRPICPLDRPCFDVRSSLCQSQCRCDPGYLKNSKGQCVLPCQCPRLPIREIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCR9</accession>
    <name>A0A6P7FCR9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger CCCH domain-containing protein 11A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114328976</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133784.1">
        <property type="nucleotide sequence ID" value="XM_028277983.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502297.1">
        <property type="nucleotide sequence ID" value="XM_050646340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCR9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646340.1">
        <property type="protein sequence ID" value="XP_050502297.1"/>
        <property type="gene ID" value="LOC114328976"/>
    </dbReference>
    <dbReference type="GeneID" id="114328976"/>
    <dbReference type="KEGG" id="dvv:114328976"/>
    <dbReference type="InParanoid" id="A0A6P7FCR9"/>
    <dbReference type="OrthoDB" id="5395350at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000026">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725:SF14">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725">
        <property type="entry name" value="ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028133784.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="54480" checksum="EC7B3EB1AC4869BF" modified="2020-12-02" version="1">MPGENFYCLDNFFKKMTDLDSPKKNNDCYFYYYSTCSKGDSCIFRHEPSALGCETMCSFWKEGKCFNIQCNFRHMELRKNRKAIPCYWESQPGGCLKGHCSFLHQNPRPVDAVNRSYLSTAESVGNLNNSERNVTVGEDLVVNFEEESDNESMPTYSPAKHKERICTVKSLEEIRLEKIQAESAAYYSYSDDSFQYDGQANMMRERIFSRMQNKLPTERTVVIPKRQNDSQFVPTLPKKRRLVFHNEDGNLEIRINKGKNKLMPKTNSIHKLERTIENHLYRQTNHKKSLPVNTETNLEDIKIKTLDEIRRERKTKEETVVTSNDENEVTSTCMDVDCQSIEKPSLQESTDTSSKKIVLKRLPIIIDTPQNVVLSDGNESTNNNLVVKRLPIIDTPQNVVLSDSNKSTNNNVVSSNVSRLSESKVTQKQCETESASSKLEETLLMEEDDLDDDTVMLKAEEELLNEVDDEWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FF37</accession>
    <name>A0A6P7FF37_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114328733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114328733</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133482.1">
        <property type="nucleotide sequence ID" value="XM_028277681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FF37"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277681.1">
        <property type="protein sequence ID" value="XP_028133482.1"/>
        <property type="gene ID" value="LOC114328733"/>
    </dbReference>
    <dbReference type="GeneID" id="114328733"/>
    <dbReference type="KEGG" id="dvv:114328733"/>
    <dbReference type="InParanoid" id="A0A6P7FF37"/>
    <dbReference type="OrthoDB" id="6349206at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038976">
        <property type="entry name" value="Ssk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692:SF2">
        <property type="entry name" value="GEO12064P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692">
        <property type="entry name" value="PROTEIN SNAKESKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133482.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14214" checksum="C93BAD9116F9EB9B" modified="2020-12-02" version="1">MAPNRLCIIKIVELAIAIVCMVLHSSTHTADYDIDTTSAITYGAFIIILVGEAAAYFWKCPLDKKIDIYYSIVGCSLFLATGIFNILRYTDQSGSKNKTMGIIKALFSLVNGVVFALDAFLTYKGEQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFU0</accession>
    <name>A0A6P7FFU0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable zinc transporter protein DDB_G0282067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114329709</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134691.1">
        <property type="nucleotide sequence ID" value="XM_028278890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFU0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278890.2">
        <property type="protein sequence ID" value="XP_028134691.1"/>
        <property type="gene ID" value="LOC114329709"/>
    </dbReference>
    <dbReference type="GeneID" id="114329709"/>
    <dbReference type="KEGG" id="dvv:114329709"/>
    <dbReference type="InParanoid" id="A0A6P7FFU0"/>
    <dbReference type="OrthoDB" id="6758292at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF96">
        <property type="entry name" value="PUPAL CUTICLE PROTEIN EDG-84A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028309913" evidence="4">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028134691.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33484" checksum="BF75ADA8217D1352" modified="2020-12-02" version="1">MHLVIVFTLCIIGAVLASHGHDNAHYKFEYGVHDPHTHDHKSQHEHRHGHDVTGGYTLKEADGTHRVVKYKSSPHGGFEAVVERVGHAQHPAHYGHGHGHGGHGHGHGGHGGATSYVGVTHWANQGSEEHGHGHGYYQSTRLQNVTTFKSNQIGGLYINRDMSRNSISSSSVTNTTTMNSVICLTLFVIGVVLADHGHDNAHYKFEYGVHDPHTHDHKSQHEHRHGHDVTGGYTLKEADGTHRVVKYKSSPHGGFEAVVERVGHAQHPAHYGHGHGHGGHGQGGHGGATSYVGVTHWANQGSEGGHGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FH20</accession>
    <name>A0A6P7FH20_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC114330103 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114330103</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135221.1">
        <property type="nucleotide sequence ID" value="XM_028279420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FH20"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279420.2">
        <property type="protein sequence ID" value="XP_028135221.1"/>
        <property type="gene ID" value="LOC114330103"/>
    </dbReference>
    <dbReference type="GeneID" id="114330103"/>
    <dbReference type="KEGG" id="dvv:114330103"/>
    <dbReference type="InParanoid" id="A0A6P7FH20"/>
    <dbReference type="OrthoDB" id="6693014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028469912" evidence="5">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028135221.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="15281" checksum="F889C796F0B2D103" modified="2020-12-02" version="1">MLRFAFFLCALMVFCNAMPDEIDLKQELAGLQILHNECKEDCGVTDGELDEARKQGQLTDNVGKYVFCMAKKTGLLTDDNKVNKDVIKERFGKRDPQVVDNILNNCITEDTVDEKGILKIIQCIMDTYGSKKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIA1</accession>
    <name>A0A6P7FIA1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114330625</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028135824.1">
        <property type="nucleotide sequence ID" value="XM_028280023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIA1"/>
    <dbReference type="FunCoup" id="A0A6P7FIA1">
        <property type="interactions" value="2221"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280023.2">
        <property type="protein sequence ID" value="XP_028135824.1"/>
        <property type="gene ID" value="LOC114330625"/>
    </dbReference>
    <dbReference type="GeneID" id="114330625"/>
    <dbReference type="KEGG" id="dvv:114330625"/>
    <dbReference type="CTD" id="134510"/>
    <dbReference type="InParanoid" id="A0A6P7FIA1"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000060">
        <property type="entry name" value="ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000050">
        <property type="entry name" value="Ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="134"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028135824.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="37110" checksum="2561ED688201CB46" modified="2020-12-02" version="1">MSTVIKIVLKWNGKEFNLESSEDDTVSDLKKTIENVTSVKCGRQKLLNLKYKGKTPEDDCTLGLLKLKPNFKLMMMGSLEEDIAEANTAPENLPDVVNDLDIEEEEVAIENQDVYLAKVEKRIKDYKINMLNDLRPEKKLLVLDIDYTLFDHRSTAQSGAELMRPYLHEFLTTSYEHYDIVIWSATGMKWIEEKMKLLGVSTHPDYKIAFYLDSLAMISVHIPKYGVVDVKPLGVIWGKFTQFSSKNTIMFDDIRRNFIMNPKNGLRIRPFREAHLNREKDRELLHLAKYLKDLAENSNDFASVNHRHWEKYKPKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FIR0</accession>
    <name>A0A6P7FIR0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114328314</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028132943.1">
        <property type="nucleotide sequence ID" value="XM_028277142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FIR0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656077.1">
        <property type="protein sequence ID" value="XP_050512034.1"/>
        <property type="gene ID" value="LOC126888061"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF4">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028132943.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26809" checksum="DE744C08A64714F5" modified="2020-12-02" version="1">MSFGNKTSFIGYLSIKRLLNMEESSGLSFINLKDSTSPFELVAEWFQEAGKCGVNMHFFNLATSTKSGEVSNRSLLLHDYVNNSFRFITNEKSLKGRDMDENPNVAACFLLQYLKDDKSHVVRQIRCQGSVIKLPYKETAKYYEKDPLFCQIRSQIVPKQGEKVDWNELKIKHDELLKNVKSGLKLRMPEYQVGYEIHPRCFDFYHSLGGEIADRIIFEKSSDGSWSSHHVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FL24</accession>
    <name>A0A6P7FL24_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114331494</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136884.1">
        <property type="nucleotide sequence ID" value="XM_028281083.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050499613.1">
        <property type="nucleotide sequence ID" value="XM_050643656.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FL24">
        <property type="interactions" value="1566"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643656.1">
        <property type="protein sequence ID" value="XP_050499613.1"/>
        <property type="gene ID" value="LOC114331494"/>
    </dbReference>
    <dbReference type="GeneID" id="114331494"/>
    <dbReference type="KEGG" id="dvv:114331494"/>
    <dbReference type="CTD" id="38580"/>
    <dbReference type="InParanoid" id="A0A6P7FL24"/>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051235">
        <property type="term" value="P:maintenance of location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008090">
        <property type="term" value="P:retrograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000002">
        <property type="entry name" value="cytoplasmic dynein 1 heavy chain 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001956">
        <property type="entry name" value="Dynein cytoplasmic 1 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="2060"/>
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    <feature type="domain" description="AAA+ ATPase" evidence="16">
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            <end position="2381"/>
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    <feature type="domain" description="AAA+ ATPase" evidence="16">
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    <feature type="domain" description="AAA+ ATPase" evidence="16">
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        <location>
            <begin position="541"/>
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    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3218"/>
            <end position="3287"/>
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    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3413"/>
            <end position="3482"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499613.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028136884.1"/>
        </source>
    </evidence>
    <sequence length="4668" mass="533778" checksum="BDA5CACD964F6F54" modified="2020-12-02" version="1">[encoded data, 4668 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FLB6</accession>
    <name>A0A6P7FLB6_DIAVI</name>
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        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="16" type="primary">LOC114331601</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="16">Whole insect</tissue>
        </source>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="71"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        </location>
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        <source>
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    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028137004.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27583" checksum="2B27B6DE6694876D" modified="2020-12-02" version="1">MRECKKSDMDEIKRTSFRFMINYAVRFLTASLFLYSCWVPFQYLGGWFSWHVILCTFGYIPLMAEAIMMFVGDDIWSKNLSRKAKYAIHGYLITFATIITIVGNILVFVYIQPGYHLYTAHGITGLISMIILIISCVLGLAVNYPTEAGRIIAIRNVTFKFIHNISGLLGYGIGIMSLCFGYYTKWFIYYNGAESRCAALIFTILVSIWPLNGAIVSLYNQYKAVLKGTKSPPSSTPPSEENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPV8</accession>
    <name>A0A6P7FPV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114329916</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of some SAGA transcription coactivator-HAT complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134995.1">
        <property type="nucleotide sequence ID" value="XM_028279194.1"/>
    </dbReference>
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        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279194.2">
        <property type="protein sequence ID" value="XP_028134995.1"/>
        <property type="gene ID" value="LOC114329916"/>
    </dbReference>
    <dbReference type="GeneID" id="114329916"/>
    <dbReference type="KEGG" id="dvv:114329916"/>
    <dbReference type="CTD" id="40035"/>
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    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028134995.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="28174" checksum="F26DACDAFB901FBA" modified="2020-12-02" version="1">MSERKSKFGQKQLFNYLSKDFHELVNNKQAMRAAMDTFLNNLIDELTLGIIFDVHRKHKINAFDLDVDENSEDVDAVDFEYLSHNTKKNQDCVCPNCDRAVAATRFASHLETCMGLGRTSRNASRRAVCSSKDNTTYSGLPSDDDDDVNWGSVKQRKKKKDKNGTKKGRGTPKKNYDQSDSIDSLNVDIEGEDEELTNLRDILRLQDHSNSTSPADSASSSGSTKKKEKSKNKKSNKRERRSPSPNSTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FR67</accession>
    <name>A0A6P7FR67_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">26S proteasome non-ATPase regulatory subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114333186</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.</text>
    </comment>
    <comment type="function">
        <text evidence="1 8">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L. Interacts with CRY1 in a KDM8-dependent manner. Interacts (via C-terminus) with phosphatase UBLCP1 (via ubiquitin-like domain); the interaction recruits UBLCP1 to the 19S regulatory particle where it dephosphorylates 19S subunit PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138839.1">
        <property type="nucleotide sequence ID" value="XM_028283038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FR67"/>
    <dbReference type="FunCoup" id="A0A6P7FR67">
        <property type="interactions" value="2319"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283038.2">
        <property type="protein sequence ID" value="XP_028138839.1"/>
        <property type="gene ID" value="LOC114333186"/>
    </dbReference>
    <dbReference type="GeneID" id="114333186"/>
    <dbReference type="KEGG" id="dvv:114333186"/>
    <dbReference type="CTD" id="6184"/>
    <dbReference type="InParanoid" id="A0A6P7FR67"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="10">
        <location>
            <begin position="36"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="11">
        <location>
            <begin position="834"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028138839.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="98430" checksum="E22B4304EAA8DECE" modified="2020-12-02" version="1">MGDTKVEPTKVDKTKGTEDKNKNELSEEDKQLQDELNLCVEKLQDNDEKRYLLALQALSNHIQASTTSMTSVPKPLKFMRPHYETMKTVHEKITDPDTKKVCADIISVLAMTMGEGRECLKYRLLSNLDKIGEWGHEYVRHLAGEIAGEWAETDFIVNTEIREKLILLTKQIVPYNMAHNAEAEACDLLMEIERLDLLEQYVDENIYHRVCLYLTSCVPYVADPENTTLLQTALLLFRKFDQYPQALRLAMQLNDFGLIEEIFVNCPDSDVQKQLAFMLGRQQIYVEIPEHTPEYEDLIEIMANCHLNNHFLNLARELDIMDPKTPEDVYKSHLENSRPPFGGNQVDSARQNLAASFVNGFVNAAFGQDKLLMEDGNKWLYKNKEHGMLSATASLGLILLWDVDGGLTPIDKYLYSSEDHIKSGALLACGIVNCGVRNECDPALALLSDYVLHNTNIMRIGAIVGLGLAYVGSNREAVLSLITPVLSDPKSNMEVIGMAALACGMISAGSGNSHVTTSIMQVLMEKSEIELKDTYARFLPLGLGLCHLGKQESIDTIIAALEVIPDPFRSMATTMVDICAYAGTGNVLKVQHLLHICSEHYDAPETPDKTSKDKDKKEAEKEKDKDLSARQAIAVLGIALISMGEDIGSEMAFRTFGHLLRYCEPAIRRAVPLALGLISVSNPKLSILDTLSKFSHDSDAEVAHNAIFAMGLVGAGTNNARLAAMLRQLAQYHAKDPNNLFMVRIAQGLTHLGKGTLTLSPFHSDRQLMSPVAVAGLMATLIGFLDVKNIILGKSHYLLYTLAAAMQPRMLVTFDDELNPLPVPVRVGLAVDVVGQAGKPKTITGFQTHTTPVLLAYGERAELATEEYIALTPIMEGFVILRKNPEFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVQ3</accession>
    <name>A0A6P7FVQ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114334679</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2. Interacts with TASOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140584.1">
        <property type="nucleotide sequence ID" value="XM_028284783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVQ3"/>
    <dbReference type="FunCoup" id="A0A6P7FVQ3">
        <property type="interactions" value="1926"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655899.1">
        <property type="protein sequence ID" value="XP_050511856.1"/>
        <property type="gene ID" value="LOC126887949"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FVQ3"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56849">
        <property type="entry name" value="delta-Endotoxin (insectocide), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028140584.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31019" checksum="789623EE884212BE" modified="2020-12-02" version="1">MAKVNEVANLYKQLKSEWNTNNPNLSKCEKLLSTLKLELTNLMFLPITTSTASKQELLLARDVLEIGVQWSIAANDITSFERYMAQLKCYYFDYNNQLPESPFKYQLLGLNLLFLLSQNRVAEFHTELELLPADHIQNDVYIRHPLSIEQYLMEGSYNKIFLAKGNVPAKSYNFFMDILLDTIREEIADCLSVAYEKISVKDVARMLYLPNEEAAKTFAKKAFQLKPWKLNNDFFHFLPEEKTHEPIPSQELAQQAIEYAKELEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWN6</accession>
    <name>A0A6P7FWN6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114334913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334913</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140851.1">
        <property type="nucleotide sequence ID" value="XM_028285050.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512778.1">
        <property type="nucleotide sequence ID" value="XM_050656821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWN6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285050.2">
        <property type="protein sequence ID" value="XP_028140851.1"/>
        <property type="gene ID" value="LOC114334913"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656821.1">
        <property type="protein sequence ID" value="XP_050512778.1"/>
        <property type="gene ID" value="LOC114334913"/>
    </dbReference>
    <dbReference type="GeneID" id="114334913"/>
    <dbReference type="KEGG" id="dvv:114334913"/>
    <dbReference type="InParanoid" id="A0A6P7FWN6"/>
    <dbReference type="OrthoDB" id="5987799at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140851.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32540" checksum="33042C4F7740526F" modified="2020-12-02" version="1">MNNNNNNCKCETDSDSDESTSEEGSDYSEDEQDSREPRSTQGRRRGRRKHHRRKKIVWPPPSNATPSTSTYMNWNLRPLHIGNPKLGDKMQLFSQTGHHLAVYADGEVRGTRDENDLHTYLEIQSGGDTGLVRIYGLLVKLYITMDSHGGLYGQIMSHDGRPFSNHVRLWCQNGYNLTIRSNGEVLGTGDDSDPDSMIEISSGGDVSLVRLLGINSQLYLCFDDNGQLYGEKDPLNPGTIFVEAFSASYSTFQSTLDSKSWFIGIQRNGKPKPGKKTGETQKATRFLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5S6</accession>
    <name>A0A6P7G5S6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="5 18">2.4.1.135</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC114337977</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 18">
            <text>3-O-(beta-D-galactosyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24168"/>
            <dbReference type="Rhea" id="RHEA-COMP:12571"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132090"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="EC" id="2.4.1.135"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 43 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.135" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_028144361.1">
        <property type="nucleotide sequence ID" value="XM_028288560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5S6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288560.2">
        <property type="protein sequence ID" value="XP_028144361.1"/>
        <property type="gene ID" value="LOC114337977"/>
    </dbReference>
    <dbReference type="GeneID" id="114337977"/>
    <dbReference type="KEGG" id="dvv:114337977"/>
    <dbReference type="InParanoid" id="A0A6P7G5S6"/>
    <dbReference type="OrthoDB" id="675023at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015018">
        <property type="term" value="F:galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00218">
        <property type="entry name" value="GlcAT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000044">
        <property type="entry name" value="Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005027">
        <property type="entry name" value="Glyco_trans_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10896:SF50">
        <property type="entry name" value="GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03360">
        <property type="entry name" value="Glyco_transf_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 17 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR605027-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028144361.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37543" checksum="91BFFAEAEAFB3419" modified="2020-12-02" version="1">MVLLESVPNDFETRKLLSLPQEEIVQQKKFADRDMKKSRKIVILLSLCVVVMITQIYMITHNVKIETVNYYTKEETDLPELYVITPTFKKPEQIPELVRLSQTLLLIPKLTWLVVEDGYEKNDRVEAVLKRKIGLNYRYLLAPMPEKYRNSSYAKPKGVSNRNKGLGWIRKYAKNGVLYFADDDNTYDVKLFHEIRKTKTVSLFPVGLVTELGLSSPIVENCQFIDFYDGWIGGRKFPVDMAGFAVSVEFLLSRPNASMPYTAGYEEDGFLRSLAPFEAKEAQILASCCSEILVWHTRTVHTSPAKRNNLTTVYKNSNLPILQELIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7Z5</accession>
    <name>A0A6P7G7Z5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Single-minded homolog 2 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">LOC114335011</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15 16 17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028140963.1">
        <property type="nucleotide sequence ID" value="XM_028285162.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140965.1">
        <property type="nucleotide sequence ID" value="XM_028285164.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140966.1">
        <property type="nucleotide sequence ID" value="XM_028285165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140967.1">
        <property type="nucleotide sequence ID" value="XM_028285166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7Z5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285162.2">
        <property type="protein sequence ID" value="XP_028140963.1"/>
        <property type="gene ID" value="LOC114335011"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285164.2">
        <property type="protein sequence ID" value="XP_028140965.1"/>
        <property type="gene ID" value="LOC114335011"/>
    </dbReference>
    <dbReference type="GeneID" id="114335011"/>
    <dbReference type="KEGG" id="dvv:114335011"/>
    <dbReference type="CTD" id="41612"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19740">
        <property type="entry name" value="bHLH-PAS_dSIM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000017">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000047">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000007">
        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="236"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028140963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028140965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028140966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028140967.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60040" checksum="C177AE3B446929CF" modified="2020-12-02" version="1">MKEKSKNAARSRREKENAEFLELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGDAWGATPVIPNPREAPIKELGSYLLQTLDGFIFVVAHDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTPTLYPPGIAPLHEHESERAFFLRMKCVLAKRNAGLTNSGYKVIHCSGYLKVKPLTGGSGPYDTSYCQIMGLVAVGHSLPPSSITEIKLHTNMFMFRASLDLKLIFLDARVGQLTGYEPQDLIEKTLYHYVHGSDILSLRLSHHQLLCKGQVTTKYYRFLCKGGGWVWMQSYATIVHNSRSSRPHCIVSVNYVLSDFEAKDLTLNLAQGTPREDIPSSPRSPIHPPTRSISSQPKYTPTHRIPVNIIPSQPPSIPDDEFSDSNGAITYPSLEYSSGFIHYHTEDPYYQHQDMFYSYSDPEISQHMLGTPQQRPFSASSSSCSSSESELHLQNLNSNNFCPEAHSFSINCFNNNQASQAAQNWQGHEFKPLIGQAHGAGYTSVIVDAQQYQLANEYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GB17</accession>
    <name>A0A6P7GB17_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Venom allergen 5.01-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335936</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142028.1">
        <property type="nucleotide sequence ID" value="XM_028286227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GB17"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655773.1">
        <property type="protein sequence ID" value="XP_050511730.1"/>
        <property type="gene ID" value="LOC126887876"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GB17"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027819652" evidence="3">
        <location>
            <begin position="22"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028142028.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32429" checksum="8B88A118EA27C86B" modified="2020-12-02" version="1">MILYIKLTVLIILTISNITYSMLEDYDSLSECKEEWPSCEDQINVMCDSRRCRPPVNRDCRPMEMDDELRNHILKEHNRLRNFLASGEETRGGVVGASNMMVLNYDYDLERSAACTATKCDMYRDRCRRTKRFERVGQNHHRAPTEQSQMQAANTWYLEIIRPALINYPAIFDDWKPFHTVSNFTQVVWAKTTHVGCGRSVSEEAYFLVCSYGPGGNRLSQPVYKKGEPATQCPPKVKRSKKYPNLCGTAHDINVAVHLHPIQNIWLYIFFTFYSFLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GER4</accession>
    <name>A0A6P7GER4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein 652-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114338395</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144787.1">
        <property type="nucleotide sequence ID" value="XM_028288986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GER4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288986.2">
        <property type="protein sequence ID" value="XP_028144787.1"/>
        <property type="gene ID" value="LOC114338395"/>
    </dbReference>
    <dbReference type="GeneID" id="114338395"/>
    <dbReference type="KEGG" id="dvv:114338395"/>
    <dbReference type="InParanoid" id="A0A6P7GER4"/>
    <dbReference type="OrthoDB" id="6784427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144787.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="45296" checksum="D2480EC8404F85D5" modified="2020-12-02" version="1">MPRISSNGKIPLKEKLYQMYINGEHRDIEILLQDGVTKAHCLILAAESPVIYKMVEHQTTDLKTIDLRQFSKLTMMWILKYLYKGDFMCPVEDLTDFKEAAEFLQLEGFRSSVKEEPSNSPKIFLQAPIIVISDDSDSSPTKIKTEETTNPRKRLKNSTRSRSASVEDCNHSKEENSFDFLDMAVNNNSEITDNKARTQSISDKGCYSTSSSDSDTELEDSSSPDFCLRVSKKNWTTPDKNKKGESSKERKEELLKLIKSEPNEVFNIPDSTSPDESIVLIENPPSSIEISDEESEAEKRRPPNIEEESHPPKSYKVPNKVKNKVWTSKHTLKKLGRTFCAICNKKQRSIKTHIKLNHRHIPRKAYFYCKKCYKKFYYESVLKNHKEIDCESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL82</accession>
    <name>A0A6P7GL82_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 68-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114344036</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150686.1">
        <property type="nucleotide sequence ID" value="XM_028294885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL82"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294885.2">
        <property type="protein sequence ID" value="XP_028150686.1"/>
        <property type="gene ID" value="LOC114344036"/>
    </dbReference>
    <dbReference type="GeneID" id="114344036"/>
    <dbReference type="KEGG" id="dvv:114344036"/>
    <dbReference type="InParanoid" id="A0A6P7GL82"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028150686.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="70290" checksum="AD6E5936B1670956" modified="2020-12-02" version="1">MVKAPAIGIDLGTTYSCVGVWQGGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPNNTVFDAKRLIGRKFDDPKIQQDLKHWPFKVVNDNGKPKIEVEFKGEMKRFAPEEISSMVLVKMKEVAAAYLGRDIRDAVITVPAYFNDSQRQATKDAGTIAGINVMRIINEPTAAALAYGLDKNLKGERNVLIFDLGGGTFDVSILTIDEGSLFEVKSTAGDTHLGGEDFDNRLVNYFADEFKRKYKKDMSRNARALRRLRTAAERAKRTLSSSTEASLEIDALFEGVDFYSKISRARFEELNSDLFKSTLQPVEKALNDANMSKSQINDVVLVGGSTRIPKIQSLLQNYFNGKTLNLSINPDEAVAYGAAVQAAILSGDTSSKIQDVLLVDVTPLSLGIETAGGVMSKIIDRNSRIPCKQTQTFTTYSDNQPAVTIQVFEGERAMTKDNNLLGTFDLTGIPPAPRGVPKIDVTFDLDANGILNVSALESSTGKSKKITITNDKGRLSQKDIERMLREAEEYKDEDDRQRERIASRNSLESYVYNVKQAIDDAGNKLSSEDKRKAQNECENCMRWLDNNFTAEKDEYDYKLKEVTRVCGPIMTKLHRGGQNGHSNNNSSGGDQDGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GLN2</accession>
    <name>A0A6P7GLN2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114343936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114343936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150579.1">
        <property type="nucleotide sequence ID" value="XM_028294778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GLN2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294778.2">
        <property type="protein sequence ID" value="XP_028150579.1"/>
        <property type="gene ID" value="LOC114343936"/>
    </dbReference>
    <dbReference type="GeneID" id="114343936"/>
    <dbReference type="KEGG" id="dvv:114343936"/>
    <dbReference type="InParanoid" id="A0A6P7GLN2"/>
    <dbReference type="OrthoDB" id="6757181at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028070873" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028150579.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15186" checksum="B659B5C4E5C93E7A" modified="2020-12-02" version="1">MKSFIIFACVLVVAMASHLPNLPEGERIKLAKVHADCQADPKTHEDEDKLRNLQNNIDDHQVGVHMFCMAVKAGLLKSNGDLDIPAITSKVSLVVKDHSKVDGLVQKCAKKSDNSGKTANLLFLCFVQNDIQYYHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GM24</accession>
    <name>A0A6P7GM24_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear fragile X mental retardation-interacting protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114340468</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147017.1">
        <property type="nucleotide sequence ID" value="XM_028291216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GM24"/>
    <dbReference type="FunCoup" id="A0A6P7GM24">
        <property type="interactions" value="1937"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291216.2">
        <property type="protein sequence ID" value="XP_028147017.1"/>
        <property type="gene ID" value="LOC114340468"/>
    </dbReference>
    <dbReference type="GeneID" id="114340468"/>
    <dbReference type="KEGG" id="dvv:114340468"/>
    <dbReference type="InParanoid" id="A0A6P7GM24"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028147017.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="73277" checksum="423C4FC7E31A903D" modified="2020-12-02" version="1">MGAPVQQGKPNRRGPGNMRGRGGNPKMRGQGRAFNGQPPFGNPGMMRGGFRGNMRPPQGPPMRGGRPPMRGRPLPPPPPRMMGPRGPMMPPMRPPPPGMRPPPGMRPPPPMMMMGPMPPPMRGGMFRGGMRGKGPFRPGPPMMPNNNFRGINKKSKIIRKGKTVPVDIDLTKSFVTEAIKAEFEKKEEFFYKAKTSQKKEDWIKYKEQRDKCADVYEEAEKGSAGQQEIGNFEYKHPEDEYIEDMYEENEDFNETDEYIEYEDYNYEENSQYYGENDCYWYQQEKQEILFTCESCDRDFYNQNQYDKHMSQHKTCNLDGCTFTAHEKMLEKHILMQHATGLYDRIRNINTPEDIAKWVEDRKKNYPSKENIMKRQIKQEAMLKRGERIKKNDNRFGKDKHRLTKAVKTKKQLPKKKQKRSFVKEKQPVSLIDEKADWNGNVFPFKGTSAIEEEKEKELSDYDDEEWSSGPSKPMEMKLNGALSALMGAYMSDSESEAEETSATIVKATPANKQEPKIEGKYPDSDGEPPTEVKNQKQKNEDAVIDKNEVEISNCTRKRKRQPYRNKNHNKDHFRSTKPHVSHSKDKFPYSFRKRKVTLLEKLLQNEIRHERNVLLQCVRYVVDNNFFMNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GR38</accession>
    <name>A0A6P7GR38_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114345418</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152039.1">
        <property type="nucleotide sequence ID" value="XM_028296238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GR38"/>
    <dbReference type="FunCoup" id="A0A6P7GR38">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660862.1">
        <property type="protein sequence ID" value="XP_050516819.1"/>
        <property type="gene ID" value="LOC126891638"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GR38"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028152039.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10226" checksum="A43B9316958B8C57" modified="2020-12-02" version="1">MPASPSSTNVGSGGRSPSKAVAPRSSMGSSVRQRKTTTTTTTARRNTGAGTGGMWRFYTDDSPGIKVGPVPVLVMSLLFIASVFMLHIWGKYTRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZX4</accession>
    <name>A0A6P7GZX4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114349056</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028155281.1">
        <property type="nucleotide sequence ID" value="XM_028299480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZX4"/>
    <dbReference type="FunCoup" id="A0A6P7GZX4">
        <property type="interactions" value="1863"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299480.2">
        <property type="protein sequence ID" value="XP_028155281.1"/>
        <property type="gene ID" value="LOC114349056"/>
    </dbReference>
    <dbReference type="GeneID" id="114349056"/>
    <dbReference type="KEGG" id="dvv:114349056"/>
    <dbReference type="CTD" id="42702"/>
    <dbReference type="InParanoid" id="A0A6P7GZX4"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000112">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028155281.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41373" checksum="9EADD0ED6DAB465E" modified="2020-12-02" version="1">MGANISQLERDIGSEQFPCNEHYFGLVNFGNTCYSNSVLQALYFCKPFRDKVLEYKAKNKRTKETLLTCLADLFHSIATQKKKVGSIAPKKFIARLRKEKEEFDNYMQQDAHEFLNFLINHISEIILAERQQNSTTNNVKSKASGENGTAHSPPEPTWVHEIFQGILTSETRCLNCENVSSKDEDFFDLQVDIEQNTSITHCLRCFSNTETLCSDNKFKCDNCSSYQEAQKCMRVKKLPMILALHLKRFKYMEQYNRHIKVSHRVVFPLELRLFNTSDDALNPDRLYDLVAVVIHCGSGPNRGHYISIVKSHGFWLLFDDDQVDKIDASTIEDFYGLTADTQKSSETGYILFYQSRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H017</accession>
    <name>A0A6P7H017_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gastrula zinc finger protein XlCGF57.1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114344434</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151068.1">
        <property type="nucleotide sequence ID" value="XM_028295267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H017"/>
    <dbReference type="EnsemblMetazoa" id="XM_050642751.1">
        <property type="protein sequence ID" value="XP_050498708.1"/>
        <property type="gene ID" value="LOC126879581"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000733">
        <property type="entry name" value="Zinc finger protein 236 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028151068.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="56771" checksum="6547479BAA9F89A1" modified="2020-12-02" version="1">MMNPTCPSDIFLWELLIIQMDNALFAVKLCALALLYLQIFLCQGHLDTNHPQLKDKSVSFFQIHKEEVHKTGITALLRYVKTDDNIMAHIIRMRANGFSCEDNMKPNSSSLLTNHDRRDSNFNPCITSIANVNTGGQHFICAICKKQLSSKRNLTRHMKLHSDEISFKCEICNKQFSSMSYLKIHIKLHTDENSFKCEICNKQLSTKGTLTLHMNSHTDENLFECEICTKQFSLKQNLNRHMRVHTGEKPFACDICIEQFSTKQRLKSHMRVHTGEKPFKCGICNKQFSQKPNLNRHMKVHTGEKSFECDICTKQFSEKQKLKIHMRVHTGEKPFECDICIKRFSVKQDLQSHMRVHTGEKPFECEICNKQLSTRSGLKLHVKLHTGEKPFECEICNKQLSTKGYLLLHMKLHTAENSFQCEICTKPFSARRYLALHMKLHTSENPFKCEICTKKFSSNRVLKMHMRVHTGENHLNLKFAPSSFQRNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H751</accession>
    <name>A0A6P7H751_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NHP2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114347935</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154382.1">
        <property type="nucleotide sequence ID" value="XM_028298581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H751"/>
    <dbReference type="FunCoup" id="A0A6P7H751">
        <property type="interactions" value="1646"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658773.1">
        <property type="protein sequence ID" value="XP_050514730.1"/>
        <property type="gene ID" value="LOC126889982"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H751"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028154382.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14075" checksum="74E6A24AAC8D2346" modified="2020-12-02" version="1">MAEEINPKAYPLADATLTTKILNLVQQAMNYKQLRKGANEVTKTLNRGIAEFIVMAADAEPLEILLHLPLLCEDKNVPYVFIRSKQALGRACGVSRSVIACSVTINEGSQLKPQIQTIQQEIERLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9U2</accession>
    <name>A0ABM5I9U2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein furry</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128190.2">
        <property type="nucleotide sequence ID" value="XM_028272389.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272389.2">
        <property type="protein sequence ID" value="XP_028128190.2"/>
        <property type="gene ID" value="LOC114324528"/>
    </dbReference>
    <dbReference type="GeneID" id="114324528"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="225"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1279"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1722"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1893"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2147"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="2431"/>
            <end position="2646"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="2666"/>
            <end position="3040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2462"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2533"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2680"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2465"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2533"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2688"/>
            <end position="2701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128190.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3057" mass="344322" checksum="BCA658FA72CE2326" modified="2025-10-08" version="1">MSDFQMDVQETDLISNDSENECSQSVCSDTHSDNTSASGLTDKSTLSESTLHALSGGSEADNFSSQSTALSGVDSKQTFTTVINRGIVLPWGAQKERSASSGQHLDMDLRPGEFVMRNLFADFTVIAEKKIESVMTESQEKPLSKSLQRGEDSEFDQLLSAFGSVAEHCLPSLLRALFSWYERQMSEVSNPEQKKSDIKQKSIINIVAGNTTETIERSEADIQKEKRDLAVEFIFCLVLIEVLKQMGLHPGHEDLVQYIENLALKHFKHHEGIQNSPNSANIHMISDLYAEVIGVLAQSRFLSVRTRFMAELKELRSRESNPNTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILVPVAAAVKNEVNVPCLKNFVEMLYSQTLDASTKSKHRLALFPLVTCLLCVSQKPFFLQNWHCFLAMCLSHLKNRDPKMCRVALESLYRLLWVYMIRIKCESNQATQSRLQSIVNSLFPKGSKGVVPRDTPLNIFVKIIQFIAQERLDFAMREIVFDLLSVARPFKVILTPERMSIGLRAFLVVADSLQQKEGDPPMPRSVGVLPSGNTLRVRKTFLNKMLTEDTARSIGMNAYFTHVRRVFVDILRALDTQYGRPLMMTNTQNVNKEPDEMITGERKPRIELFRTCVAAVPRLIPDGMTAGELVDLLSRLTVHMDEELRGLSYCSLQSLVVDFPDWRQDVLWGLTQFVAKEVLDTFPQLMDHGLKMILTLLGAWKAAISGTNVSTFTSSTLRGKEYNELKAGPPDPNLTKRTDTAKSEPLASVLHFVEALALVMLCTYRLTTRRLSVLILKEVKSLLKALNCSENPPVIDIMDQYCPQVVEKCLLLLPPAEKTAIQAVSLVGSVDLQWLADRSSSVWTAGLFEDGSIKNAANYTFSIVDPWSVCYFGFLERDRLLSLCTLMTMHSWPIVFTRLNALYSVVDPTPLNDNRASLLRSATAVKKPPTERDAYMHLWKNYITFAFRVVPLIANPIVRCASPDLSLSSSPDSLNTEKNDNKLPATNISPVSLYKLVVPHLRCEVTDIRDAAVYALGNINGNALRDLFEELTVYVREAVDKKQENVRRRRRRDALRLQLTRLLEFIAENETFGMSGCALDRDSQSLIPILIEFIDGVRYYLENEPDKNSTTVKDLTLHFGYFLRKMINNFTLETRRSLLKRDLRRNLFTLFGNWAGKYGFPTGKANSEGDMNNKKHVELQLISLQAMSYLLCCGPCFDSLTEESSYYLWIDGLLNSSDEKVYSLAQETVILLLESNPDVSPLLDWVVDKCYTGTSRVADSCFIALATIFSAREYPCDHYTAIINVTLMNTGCPRQVVRDTALQLLQLLDKRFFGCVGPLAENDLAEGDKGRSTLDTILATTYCRSQIHLSRQLSLLHPELTMPMFSEITYRFQTARPEVRQLLLQYLLPWLHNMELVDPNIPPTNTHMYQFYSAEIATERKEGWGSAEATEMVLTNIFYITAKFGDNHPKEIEEIWATLCTSWPNNMKVIIRYLIIVSGMAPCELLPYAKRVVLYLARVQPVRLLDEMMVELQTVETLNCLIERTETPPFYRLTVMRKASSHSDGANGVPGQTDSSSRNDLSIEKGTIHTKRHSGEDPSKTSVMKSDSGSNIFSDFAMSRPDKPKNQEEMISSLEEVAIEEDVLLRDKVNMSVPQPHPLPMPEFGGYFAPLTEYLPDSSQPISGFHRCNVGVMLLCDIVVDGIELDWTIHVPLMLHILFLGLDHTRALVYQHCKQLLLNLLVVLALHNDHLTVAHIILNSKTKQLELGLLTPTLSTVVEHTFTESSPILNEFLLHQIGGSGAAVEALNKSAAQAVSNLKPEETVEEKETPIPQVVVVPENAEPAPTTKVQLTVSVIIKSLIQFLATRQNSPLWNYEDITAKVWSIKSVEQIDIFIQYILKVFRESLPNAHINERWAQTALQLGLSCSSRHYAGRSLQIFRALRVPITSRMLSDILSRLVETVSEQGEDMQGYVTELLLTLEAAVESLESDFRPLDFMKDFFKSTPNLNNKEAGPLRKNAGDSHINVAGTPVFYSPIIGHARSTSYSVSYGFRKNTQSATDVKERNRHSNEIDHRSAINKFAPNNLSRSRSAQSLKMLGDTATQDDKLTILAQLFWLAVSLLESDYEHEFLLAVRLLASVMHRLPLDRPDARDKVEKLQSQLRWNSFPGVHALLLKGCTHPNIYEPVTALLSHFTTLLNFVVVDPSQSIAFPMNVIALLPYMLLNYEDANELCIRAAENIAQVSIEKSKKLENLGTVMNLYSRRTFSKESFQWTKCVVKYLHDTYSHLSLNMLSFLIEVLEKGPSNLQLPILNIIHCILHYVDLATAAAQPVNADLLKVIVKYIEGPNWREALKILKLVVSRSSSLVAPPITIHSHWESSLTPMPHPSFNEDNIFSKKELPGRTMEFTFDMSQTPVIGRRFLHKTEEASTSKISSTPRRSCSISPADTSPQSGWKRPWMCQGRVRECLVNLLTTCGQRVGLPKSPSVIFSQTSDIIERQSSMASSTEEVSAGNNDMSGGSRRDDAATEFGVFKDFDFLEYESESIEGESTDNFNWGVRRRPLSQGEDDQTNLKQLEDSVSEKTPVLTVRKVHVCPFDHNRLLTEESSDDEVGSESPLDEIAIAPEFDNSIMESSAMFPPSSLALRENNSQVQSSARSDTSGSSTGDLGEVTPCNASPNLSTLMNMRPIISKSDMLENWSSYIQANMLQTPANTLQFFHQFQKLVTDICISAIEITKESCSYMSQSAMSGLPTIRLISSRLLSMVDIVKYRVMVSNLIWFNTVAIKDSRFIETLKYGMLEVQEHLETFCDKKEQASMFCDAVKTTLKLERLSGQQSEFHNEQYLLDLGKALYKLYFQLLLLIEVGNKMVANLHSSLKSADFKDITGDMMSIRSALTSSYEDTDADGGISSAMFGRVSSDNLISDLCRLIENEKWTSVILYFKCNKEEFVKEFEELCDRENDVLTILNIYCKKLVHDKPEYYVISNQEPDLSDVFGRLFQVSAAVSDLEGILKEQPSKSADAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IC40</accession>
    <name>A0ABM5IC40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nexilin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129577.2">
        <property type="nucleotide sequence ID" value="XM_028273776.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273776.2">
        <property type="protein sequence ID" value="XP_028129577.2"/>
        <property type="gene ID" value="LOC114325660"/>
    </dbReference>
    <dbReference type="GeneID" id="114325660"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129577.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="60876" checksum="B44A17C10E5F8FC2" modified="2025-10-08" version="1">MEKSKLNEMVKALQDAGMYENNLTEQDIQEIYKAVSNSKDTALEESRKYESDEDLFEEASTQTLPNVKNVEVEITSKKEESKNVFQPKTWTFDKKPSDTQNGSTKEENSAEDATKANIRFEDMVTPNEPMLKIIYHPKQFTNIQNCQKFLKADVSTKAMMLYSYHTNMERLRSKLARQSFYAVAMPKPIVLKEQVIPSLDRDDDFEDTYISRSGRQTKRKCYYTEEENSQDQETVSSSNKKQKSKNEDEQEWLSKTKSASKTVGKKLDLTPKLDLTPKIDSQKFMEIQPVEEEEKEIQNDDKKEVAKPRSKKLTNNEKIMSKSSLFAEPIKKSRTPRCELMFDKLREETVKKQKEEKEQERFERSLNVDSDDNQVDSQKDEDIISIEAEPVRRRVIPPIPTKRRPIGNRNKQQQQTNRLADALDKIVPSRTRQNDKSPVKENDATVSSSTSVGSSTDVNCPVCDKLYSKETVEAHAWTCGQGEQMVTRSALQSSSKLSCEICDKVVLDDYDLHVQQCLDQEKKKNKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDX1</accession>
    <name>A0ABM5IDX1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130680.2">
        <property type="nucleotide sequence ID" value="XM_028274879.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274879.2">
        <property type="protein sequence ID" value="XP_028130680.2"/>
        <property type="gene ID" value="LOC114326484"/>
    </dbReference>
    <dbReference type="GeneID" id="114326484"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130680.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="223" mass="25991" checksum="7B716743FDAB54D5" modified="2025-10-08" version="1">MESVTMDTKNFTWYRDEAKWTKIIIPSGTMDPNQSTVIQIPEDLQHNEVIIARNAQGQDNGGEQSNEQYNDQQQFRPCPAVSREQENFEPSFEQEPQVNYQNGPTQRASTQPPQGQYQSQNGPLEQEDPECDNMLELTTEKEAEILSLIKETDRERGRLYVLPINKKIRLMEQMEYIETGVVRRDLKEFQETRRKLVFDLQSLLSTLPNVRQTVRAIDVRDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IEV8</accession>
    <name>A0ABM5IEV8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dopamine N-acetyltransferase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131279.2">
        <property type="nucleotide sequence ID" value="XM_028275478.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275478.2">
        <property type="protein sequence ID" value="XP_028131279.2"/>
        <property type="gene ID" value="LOC114326986"/>
    </dbReference>
    <dbReference type="GeneID" id="114326986"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF28">
        <property type="entry name" value="GH28833P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131279.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26896" checksum="7AD4B6D13279EC99" modified="2025-10-08" version="1">MTIKIWARSEDGTIDYISLTKEYVPGALNVLRKSFYREESDCLAAGVANSEDAMCEVDNFMTNMAKHGVSIVAVERKTNTVCGVAVNEIREINTHPVVTHCVDKARHTATKSFLKYVEEADDLLSIFENCKVDCYIELFCLSILPEYRRRGIALTLAKVTEELTRQLSHGKPVKQSLDDSDLPLEPIPKMIAVIFTTHGSKRLGEKVGWESARSLKMSFTKDDTDCFNVMFKKMSNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFW8</accession>
    <name>A0ABM5IFW8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131838.2">
        <property type="nucleotide sequence ID" value="XM_028276037.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276037.2">
        <property type="protein sequence ID" value="XP_028131838.2"/>
        <property type="gene ID" value="LOC114327423"/>
    </dbReference>
    <dbReference type="GeneID" id="114327423"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131838.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="442" mass="51516" checksum="26E0D41EB7D75741" modified="2025-10-08" version="1">MNIGKSNLIFTMEIKQETSEKTCKIEIDNEAGVNLLDVFKIEIKEDPKKESAYETFVYLDLNEFPVNTKVEKDEYKFTLFEEKQTTNEESCSQEDNKMKIMETSHSTHKGKYTGQYAEGKILNKNMKPATGQRSYKCEICFKQFSRKDILRKHSIMHTGEKPHKCEICFKQFSRIDAFRKHSITHTGEKPHKCEICFKQFSAAGNLKRHLRVHTREKPHKCEICFKQFSHASNVKRHLRMHTGEKPHKCAICFKQFTQANSLKTHSRVHTGEKPHKCEICFKQFNQAISLKTHLRTHTGEKPHKCEICCKPFTTIGQLTVHLRTHTGQKPYKCEICFRKFNQASNLIAHLRVHTGEKPHKCEICCKPFTTIGQLTAHLRMHTGQKPHKCEICFKQFKQASNLKAHLRVHTGEKPYKCEICFKQFTTIGQLKVHLRTHTGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IG69</accession>
    <name>A0ABM5IG69_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028132038.2">
        <property type="nucleotide sequence ID" value="XM_028276237.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276237.2">
        <property type="protein sequence ID" value="XP_028132038.2"/>
        <property type="gene ID" value="LOC114327563"/>
    </dbReference>
    <dbReference type="GeneID" id="114327563"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132038.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="368" mass="41389" checksum="047C1438F0F6173D" modified="2025-10-08" version="1">MFARNKLFPKFSKRLFCSKSIKTETKYQKRIFSGIQPTGAIHLGNYLGAIAQWVKLQDQGEHVILAIADLHSMTLPHEPKILSRNIQEIAATLLACGIDPNRTILFQQSKVAVHTQLSWCLGCICTMPRLAHLPQYKEKSKDLKDIPLGLFVYPVLQAADILAYKATHVPVGEDQIQQIQLSQDLARMFNKKFGETFPIPHALTTGSEYARLRSLRDPSKKMSKSDPDPKSRICLTDRPDDIVRNIKKAVTDFNSEVTYDPEGRPGIANLINIHSFATNKSVEDICKDAKNINTGEYKLVVADAVVNFVTPIQERISGYLSEPQLLLEILEQGREKADDIASKNWDEVQYKLGLNFKAKAAKKVKVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IG80</accession>
    <name>A0ABM5IG80_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket protein 28-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132047.2">
        <property type="nucleotide sequence ID" value="XM_028276246.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276246.2">
        <property type="protein sequence ID" value="XP_028132047.2"/>
        <property type="gene ID" value="LOC114327572"/>
    </dbReference>
    <dbReference type="GeneID" id="114327572"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF243">
        <property type="entry name" value="PICKPOCKET 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132047.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="66128" checksum="646376CB5A5CA478" modified="2025-10-08" version="1">MLKTDSIIRPRRIQASTVNYLDNNNFKNGVQPVYRIPDAPDLKVNIANFGNKGHIPGSNRSRKEQTKSITGKVLLELEHYCDKTTLHGLRYVGDTSLTVCERVFWLLSFSVAIAFAAYYISNIYQKWNSSPVIISFSPFDAQLKSIPFPSVTICNMNQAKKTEVNKIKADGNPLDMKLLDDICNGNDSNHNNYTEQYDWTMLRNFLIRVGNSCSDMLKACKWSSDKKSCEDLFNNDLTDEGLCCSFNRLPPTKIFRNPNDISLLNQTYPENVYDWNPEIGFSNLEDYDDENMVPKRPLGAGAHLGLSILLDAQVDEYYCSSTSSIGFKVIISNPIETPKMADFGTLLSPGVEARFSIKPSVREASANLRSVPIKKRQCYFANERRLVYYRSYTQTNCNLECQSNYTYEKCKCIPYYLPRNKSIKACGRRDRECSQDAKENMEKINGNGTSCSCLPGCFELVFTDMKSFGQLSKVLNITTFGDDVVINTTYLMRDMAVVHFFFSNSQFSKLVKDELYGFTEILSNVGGLLGLCMGFSFLSVVEILYFITIKRLCCWIRGKRKNNQKIEMLFNSGVSKYPFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJU3</accession>
    <name>A0ABM5IJU3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134478.2">
        <property type="nucleotide sequence ID" value="XM_028278677.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278677.2">
        <property type="protein sequence ID" value="XP_028134478.2"/>
        <property type="gene ID" value="LOC114329533"/>
    </dbReference>
    <dbReference type="GeneID" id="114329533"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045747369" evidence="2">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134478.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="133" mass="14819" checksum="DAD5F6E959E0DC31" modified="2025-10-08" version="1">MKCIIIVATVLCVLAATNAAPNKEQVEHMKKAHEHCQSQEATRVDESVYEKRRNGEKVDEKKLAKHTLCINVQAGLQKENGDINVDKLRELLNDGTRDLNLINRVVEKCSKKEGDTTEDAAVNLVKCIASHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKL8</accession>
    <name>A0ABM5IKL8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Balbiani ring protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134994.2">
        <property type="nucleotide sequence ID" value="XM_028279193.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279193.2">
        <property type="protein sequence ID" value="XP_028134994.2"/>
        <property type="gene ID" value="LOC114329915"/>
    </dbReference>
    <dbReference type="GeneID" id="114329915"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF31">
        <property type="entry name" value="PAPILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IKR5</accession>
    <name>A0ABM5IKR5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Insulin receptor substrate 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein chico</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Bindings to phosphatidylinositol 3-kinase and SHP2.</text>
    </comment>
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        <property type="gene ID" value="LOC114330008"/>
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        <property type="entry name" value="PH_domain"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        </location>
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        </source>
    </evidence>
    <sequence length="1259" mass="137503" checksum="73570A9BADAEF869" modified="2025-10-08" version="1">MSLKSIGPQRGGGEVLRSGLFKKLKTSRKKWFVLRAETSECSARLEYYDSEKKFNSGQPPKRSIPLKTCFNINKRQDIKHKHVIALYTKDDCFCVVLDTEEELETWLKALLSLQHGEDPTDGEAPRPTYEHVWQVVILNRGLGTGRTGNYRLCLTYKTLCLYKKDRDSSVTLNLSNIRSCGTLKNYFFLEIGRSSQLGAGELWMESEDNTIAQNIHTTVYHAMTHQRQHDKQNEKQNEPKPEEMRVRSSSATESSKPTNNSYRKQVVSGVPKTTTAPSVFSTQSGGVGSPGTTISHQRTQSLPLTDHPPPAAVAPLSTTSTTTTISSTITDNSFHPSSRVPITTTTTFNVNKGRSNQATKCRERCDSMPSRPRTTSEGNHQLTSWRPYLAPYRSHGRDISHSPPSGSPISPPSVGCSTDSAGSSYSLTDEADMYGECPDLGRYNSIPLTPDEAIVEEDCSEGQCGMYDSYVPMTLQSTDDGYVDMVPRYRHEIHSPTASVSSVVSGTPSTDIRFSDYPLDKVASYLTSEEDGTRTARAYSCGSKPETLKGKKHAEISADSARVRAFSVGSKTKKGPSRILSHQHHASLKSISAPILSNSRSHSSHSSNDPMDDLMEMDFSKASNNNHSGMDSGNRTITTNNGYVEMKPGVEIAPSHNSDVSPYVDMSGASSYMDMSGSSPSSRHEDECSSFVDINRQYRLPANNNYVDMDAGRKNRTKPSTSPAWTSDYCDMSGGMNHSRRSERGSSFSSQLSTSSSPRNNDYLSMNFSPQDNPKTPEGYVDMSLGKRHQRQGSLDGNQVNGGGNDDYLNMSIGPKKKVTKNQMVMSSPISIHPTTTSQATKHSSSPISISSLLSRKSSTGTSPKMHLPISSWTSSLPRNRARKDSKDSSSSSVTTPSSSSIIFPMSPSSPLKVIKPETPPLNPKPSASVLNSLYKTGTRQPSSDDYAIMGFDSGRNERDKENSDYVNYSAAVSNKIDSNPKKGSLFSTTSDYACMQSSSDYALMQPSSDYALMQPSTTTAEVTDRRESLDTSPLIGHLSLIGIKESQSMCFQPIKEDSGSSPVNKGGRKIDDSSDYMELSLSASSSECVSPAAKISRPNSVNSESAAKSNFLSRGNSDKSRPPSVSSDTSRSATSRPSSTSSELWSSSSTLVNSRPESVNSDRIEGNWTNNPSQKDAKPEEKTENKLHYASLDLITQDEESRSPRNTKGSQSSEEASSSVQGEPTFVYAEIDFVASEGLKQNSNSNQSLGNNNTKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQA2</accession>
    <name>A0ABM5IQA2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138694.2">
        <property type="nucleotide sequence ID" value="XM_028282893.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282893.2">
        <property type="protein sequence ID" value="XP_028138694.2"/>
        <property type="gene ID" value="LOC114333067"/>
    </dbReference>
    <dbReference type="GeneID" id="114333067"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138694.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="412" mass="48848" checksum="454B8AD2D554F6BF" modified="2025-10-08" version="1">MEVKEASCKIEIENNEIRDVSLDIFKTEFVKEPKEESNNDACDYLESTDNPVKTQIRQDEYTVMSFEAVQLEDKKSFLQREIRMETMKTASDYSCYEEYVSRQPEETTLNKPRIEQGPYNCDVCFMHFTKARYLQVHLKTHTEKKPHECEICLKQFSQQSYLKKHLKRHLIMNTGKKPYKCEICLKQFSVAGNLKNHLKLHTGRKSYKCEICLKQYSEQGNLNRHMKIHTGEKLHECEICFKQFTVENHLKIHLRTHTGEKPYKCEICLKQFSVGNNLKQHLRIHSGEKPYKCEICFKQFTIKSTLKMHLRMHTGEKPYKCEICLLQFSHQGHLKTHLQIHTGEKPYECEVCLKRFTVAYSLKMHWRTHTGEKPYKCEICLLQFAQLSHFKTHVKIHTGDKSYKCEIGFEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUA8</accession>
    <name>A0ABM5IUA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mucin-5AC-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142203.2">
        <property type="nucleotide sequence ID" value="XM_028286402.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286402.2">
        <property type="protein sequence ID" value="XP_028142203.2"/>
        <property type="gene ID" value="LOC114336077"/>
    </dbReference>
    <dbReference type="GeneID" id="114336077"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142203.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1387" mass="151209" checksum="D12C49BAA42BE13B" modified="2025-10-08" version="1">MAGSGSYTVNRRKDASFKNFICALVAFLAMLILISILLWALRNRGSGSESLLSTTPVPTNDTGEHSAHLNGFITGEKSKNVSTTTHRNTHKPEEKDPNNQESAKTPAFVPGGSPDTTTEAVTTNKNNLPSSSSQPNSALASQTQSSTIFTTPVSSTIVSSATTALYAVSISTKLAETSLKPTRETPTAVTTTVETTTLPTTTESNPQKTNISDNSSDTTTEVVTTNINNLPSSSSQPNSPLASQTQATTRSTTPVSSTTVSSATTTLTTTLIPIILPKTSVKPTTETPTTETTTVETTTLPTTTESNPQETNISGGSSNTTTEVVTTNINNLPSSSSQPNSPLASQTQATTRSTTPVSSTTVSSATTKLTTTLIPIILPKTSVKPTTETTTTETTTVETTTLPTTTESNPQETNISGGSSDTTTEIVTTNGNNLPSSSSQPNSPLASQTQATTRFTTPVSSTTVSSATTSLTTTLIPIILPKTSVKPTTETPTTTTVKHLETTKANVTAETTTVETTTTESNPQETDFIPDYSEESVEVVDTTKKTNLVSSGSPTTLAFQSQATTILTKTVSSTTVSPATTKLTSTLVPTVLVANSVKPTTETPTTTTAKHLETTKANDVAETTTVETTTLTTTTESNPQETDFIPDYSEESVEAVDTTNKTNLETSSSPTTLASKSQATTILTKPVSSTTVSPATTKFTTTLVPTILVATSVKPATGNTCEEGVCKRAASVMLAMMNHEDNPKVCDDTQNMDYFSVICDKPGESRNSRFFKSSFRNFYKKLNESTEDSVKFFLEFYESCNKFENSVHRLNRTKALSGTGGADVTETVIKSILAESMPFFDLGLNIVEDEFVFEISLPGVNYLKTKVKGWSVVDQSKDFCIAAEAGTISQDVIELNKRSENINSCIKEITNGYINEFLIEMQELTSSLSSGKDNLEAIVKSGQSSNDLIAILDSIQESWKVYRSDKDPSVKQKMMTLTELSTKYALGFDWIAVLSKVTTGAIAGDTKVYFSEYLDQPFTTLASKTAGLKDMLDLWYSVQMYKNVVMEKQTGNLGHYCMQLTSELIPELSSHIIYELNNKKEHEELYALVDTLLNNLKTRFENSLEQAKFVTDSYKILGDRINQLQLSRPQAISLTDVSISKINGVYQDQLYQLMEHYKKQIYNQVGQTITPEILLKLFVGAFETEPKTYPPNRKIVFQPGFVSDMNKNVPYYIRVAKHGLLLAEQIAKQFIKNDFTDLASEEATLYEDLFKTLDTKYLVDNSFYTIENVKCQVEDESGNNLKYETIVGDNLAFRLATDTFLEDTSKDTLPFLADYNRNKTFLINALQDFCKPNNVADFIGDFYNKETIPAPLRIRNMAKNSQLFADTFNCKDNFERKQFPFLKPVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IV27</accession>
    <name>A0ABM5IV27_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bladder cancer-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a tumor suppressor; induces growth arrest at G(1)/S checkpoint and apoptosis via RB1-dependent and p53/TP53- and NF-kappa-B-independent mechanisms. Modulates expression of genes involved in the regulation of proliferation, cell cycle and apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BLCAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143146.2">
        <property type="nucleotide sequence ID" value="XM_028287345.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287345.2">
        <property type="protein sequence ID" value="XP_028143146.2"/>
        <property type="gene ID" value="LOC114336966"/>
    </dbReference>
    <dbReference type="GeneID" id="114336966"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143146.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8702" checksum="45A6C53985A0D876" modified="2025-10-08" version="1">MYCLQWLIPVLLMPKPSNPALVQTHVMFMVLYLIGFFLERKPCTICSLVFLAAVFLICYSGLGNCLLWSSHCDTDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IV59</accession>
    <name>A0ABM5IV59_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143276.2">
        <property type="nucleotide sequence ID" value="XM_028287475.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287475.2">
        <property type="protein sequence ID" value="XP_028143276.2"/>
        <property type="gene ID" value="LOC114337096"/>
    </dbReference>
    <dbReference type="GeneID" id="114337096"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18445">
        <property type="entry name" value="BACK_KLHL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18235">
        <property type="entry name" value="BTB_POZ_KLHL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF466">
        <property type="entry name" value="RING CANAL KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143276.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="643" mass="71710" checksum="C2480015B7DFDC87" modified="2025-10-08" version="1">QLSTIIDFLTLAERLLLLCKNTNYLFCCCVYVYIKLLKMEPNVNIMERQGSCLLLRSASQNSLDESSQKHISQIHPHTKERPPYRNHLHTQKAFDVMNVMRKQKLLCDVVLVAGDAEIAAHKMVLAACSSYFYAMFSSFEESRQDRIVLQEVDQQALMLLIEYIYTSEVSVTEDNVQVLLPAANLLQLTDVRDACCDFLQAQLHPTNCLGIRAFADLHGCLELLSHAESYIELHFSEVVECEEFLTLSHLQVSKLISSDRLTVPSEEKVFECVVAWVQNDLDNRRNHLSSLMEYVRLPLMSQEYLVQRVEEEPLLKTDLQCKDYIIEALKYHLLKGDNKTSFRTPRTKPRQPVGLPKVLLVVGGQAPKAIRSVESYDFKEERWYQVAEMPTRRCRAGLAVLGGKVYAVGGFNGSLRVKTVDVYDPALDVWTSCESMEARRSTLGVSVLNNCIYAVGGFDGSTGLNSAEMFDPQTGKWRIISSMSIRRSSVGVGVLYGQLYAVGGYDGASRQCLSSVECYTPETDTWTMVPDMCCRRSGAGVGVLDGILYAVGGHDGPLVRKSVEAYDPAKCKWIAVTDMALCRRNAGVVAMNGLLYVVGGDDGSSNLNSVEVYNPKTDCWIMLSSSMSIGRSYAGVAIIDKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IV95</accession>
    <name>A0ABM5IV95_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028143419.2">
        <property type="nucleotide sequence ID" value="XM_028287618.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287618.2">
        <property type="protein sequence ID" value="XP_028143419.2"/>
        <property type="gene ID" value="LOC114337213"/>
    </dbReference>
    <dbReference type="GeneID" id="114337213"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF29">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046143615" description="Sphingomyelin phosphodiesterase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="13">
        <location>
            <begin position="468"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143419.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="613" mass="71429" checksum="E938BD7EC7CC3D51" modified="2025-10-08" version="1">MKFWLILVCYTWIFAECHTTKNRTALFEQIKKGIEEIKTFNKASATFETAIKEYNIPNIFTSSPDNFDKEEVCSTCLSISDLFIQKRREGLKDVDFHKQLVYFCNLISGQKERICEGLIKLNAPILLYVIDNTPELTGQDICGISLQDYGCNGSKRLEWSIDIPPKTNIKQNETPATENTTSFNILHISDIHYDPRYTTNKTTKCGEPICCQDDQADGTTEKDTCGYWGSYTNSDIPWRTAINALEQTKLHKYDYVYFTGDIVAHRIWNTSLEENTRVISQVLDTFADIYNVPVFLVFGNHEAHPSNLYSEVQDPLYSSRWMYDILFQKMSKWIPLDEVKDTLLKGGFYTVSPRKGFRVVVLNNNICNINNWWLYNNPQDPYDQLKWLVKVLFEAEKNSEKVHILYHMVPGQSDYYKVWAREYKRIIERFSDTITAQFNGHSHKDEFYVYYNTTNQSQALSVLWNGASIVTKQKVNPSYKIFSVNDATFELLDFEEWTYNLTLANLDENEPVWYKLYSFKETYGVKSLATDEINNLILRMAENPDLIKQYYKYKFRGSDISIEDECGKTCQKNLLCSMVTTQYADDGVCKKLLKLFKKSRKLKGPRRMSLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IYJ6</accession>
    <name>A0ABM5IYJ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149518.2">
        <property type="nucleotide sequence ID" value="XM_028293717.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293717.2">
        <property type="protein sequence ID" value="XP_028149518.2"/>
        <property type="gene ID" value="LOC114342914"/>
    </dbReference>
    <dbReference type="GeneID" id="114342914"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="5">
        <location>
            <begin position="238"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149518.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="499" mass="55576" checksum="CEC7C6E456B315A2" modified="2025-10-08" version="1">MLFKFCKSILSCTKRNIYSLRSDTIFALSSGHGKCGVAVIRVSGSNSETALKLMTGLSSTPMPRTAILKSIKNPINGEVIDKGLVLWFPGPKSFTGEDSVEFQVHGGVAIINAVLDSLGTISNLRLAEPGEFTRRAFFNGKLDLTEVEGLADLLQAETEAQRKQAYLQSQGSLSKLYNKWRTTLIRNVAHVEAHIDFEETETMDFGIIDSVKHDIQKLVKDIETHLADGRKGEILRCGVRTVILGEPNVGKSSLLNLLCHRPAAIVTPIEGTTRDILEVTLNIGGYPLVLADTAGLRSDSIDVVEKEGISRALQLYEKSDLVILVVDSERYLRWKNDHADLSFKDYLVDYLEKLKLSDLLKSTNTSDIHFNKQCILVFNKADLSEENIDVDMKTCVSISCITESGIPTLIESISSHLKDLCGEPTVEHPSMNQIRHRQHLTDCLKYLRLFIKSSDNHNQDLVIMAEHLRRSLKHLGKLLGKVTTEDLLDVIFKDFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ39</accession>
    <name>A0ABM5JJ39_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 9e2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497956.1">
        <property type="nucleotide sequence ID" value="XM_050641999.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641999.1">
        <property type="protein sequence ID" value="XP_050497956.1"/>
        <property type="gene ID" value="LOC126879083"/>
    </dbReference>
    <dbReference type="GeneID" id="126879083"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60821" checksum="66486A8477EB2856" modified="2025-10-08" version="1">MLNLIIGVAIVLALIYFLGIKPFNYWKKRGVKQGNPAWFLGDSYEQMTKKQTFAEMVQKVYNIGPGARYAGMYQFMTPILVIKDLELLKQLFVKDFDHFTDHSKFVSEESDPLWAKNLFFLTGQKWRDMRAILSPAFTSKKMKSMFFLISETADDFVNYFLEQNKDSIELELKDKFTRFTNDIIASIAFGIKIDSLKNPNNEFFVMGQDITSFSGFKKTLKFMGIVMIPKFFTFFKIGFFATYVRKFFINLIGDTVKTREEKNIVRPDMLHLLIQARNGGLENGEKSQNGEIETAEAESNELIRKAAKNMTVVDIAAQALIFFFAGFDSVASLLSFTCYELMVNPDIQTRLRKEIEETLEECNGNVTYEAIMKMKYMDMVLSETGRKWPQGTMADRVCTKPYTIPAERPGEVPVHIDVGAPLWIPIYAIHRDPENFPEPERYDPERFSEENKSKIKPYSFIPFGVGPRNCIGARFALLETKIVLFKFLQHFELVPSEKTKIPVEISKKQFNLTAEGGFWFNLKRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJV0</accession>
    <name>A0ABM5JJV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 6a14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498210.1">
        <property type="nucleotide sequence ID" value="XM_050642253.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642253.1">
        <property type="protein sequence ID" value="XP_050498210.1"/>
        <property type="gene ID" value="LOC126879200"/>
    </dbReference>
    <dbReference type="GeneID" id="126879200"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58595" checksum="C6AD9E643103FF12" modified="2025-10-08" version="1">MAVNIFVPLVIILATCVYLYSKKKFLYWKDRNVYHMEPTFFYGNIKTVIKDHAHLTTVVQRLYDEAKTLKKRYCGFYTFFQPHFVPVDIELVKGILQNDFDNFLNRGRYFNEKADPLSGHLFNLEDEKWKKLRIKLTPIFTSAKMKVMFQTLLDSTERFQKLLERLANSEQPVDLKNAFACFTTDVIGSIAFGLECSSMENPDSEFRKYGDEAFRKGLRQRIGIVLTSVFPWWLVRLTGYKTFSKDMDNFFTNLVTEVIEEREKQKIERKDYLQLLVNLNKSAKDKGNMQALTMEEIAAQCFGFFIAGFETSSMTMNFAVLELSQNIDVQEKLREEIVAVLSKHNNQITFDALNEMVYLDKVMQETLRKHPPLGILVRICNRDYKLSNDDLILKKGTMVSIPIQAIQRDPDYYPDPEKFDPERFNKENINQRPAFSYLPFGEGPRICIGMRLGKLQSKIGLITLLKNYRITFNEKTKLPLTLAFATISMPKDGIWVNLDPIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMN1</accession>
    <name>A0ABM5JMN1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499197.1">
        <property type="nucleotide sequence ID" value="XM_050643240.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643240.1">
        <property type="protein sequence ID" value="XP_050499197.1"/>
        <property type="gene ID" value="LOC126879896"/>
    </dbReference>
    <dbReference type="GeneID" id="126879896"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="120"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="410" mass="47940" checksum="01E50BB3E7527923" modified="2025-10-08" version="1">MEIVEEHRSLLDRIASENGFTNYEIIASPGSNKGDNFSGIITAVTIKNKEKSLDLILKSSRTFSKQSKEHHIHVYKREIFMYERIFKEFKKYQKEHNIQDPFESVPKYYSSFTEEGQHSLVLENLKSQQYQLWDKKVPMNPEHIKTVLIEYAKFHAVSLAMKHKNPELFETLLGETNLDNPMHKLFDGDNNEGRENIKSFFSATLSMGYKAVKDDVALTEYLKKYESVAFENMSKMRQPEYKIVVTHGDCWCNNFMFKYQDPNDKTKPQIIRVIDWQISSFGNPCEDLAYFFVANGSEEVLGDFQAYLHVYHEKLSSQLRNFNLDPEEIFPFSTFENHLKVFILHGLFLALLVMKVTLSDADEIPEHGEEGEKQSPDEILDLLSKEMKNMDVYSKRIKIVMNFLVKNHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JNS5</accession>
    <name>A0ABM5JNS5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499588.1">
        <property type="nucleotide sequence ID" value="XM_050643631.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643631.1">
        <property type="protein sequence ID" value="XP_050499588.1"/>
        <property type="gene ID" value="LOC126880036"/>
    </dbReference>
    <dbReference type="GeneID" id="126880036"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047476162" description="Cathepsin L1-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="110"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36163" checksum="CF5F9583D58AC506" modified="2025-10-08" version="1">MKILIAFAAIILSVSALSLKQHWENFKVKHGKVYKNPIEERVRFSVFQSNLKLINEHNAKYEQGLESYTMGVNQFADMTPEEFKAKLILQTKNMPNIEKSLHVPNLNDEVPDAIDWRQKGAVLEVKDQGKCGSCWAFSATGAVEGQNYIVNGQSVPLSEQELLDCSGGYGDGNCHDGGLMTNAFKYIQDLGIESESDYPYKAVRQYCTRSASKTVVQIQGYKELEANEEALKQAVGAIGPISAAIFADPIQFYSGGIYDNKKCKAERYLLDHGILVVGYGEENNKPYWVIKNSWGKSWGEEGFFRLERGENLCGVALMASYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JP66</accession>
    <name>A0ABM5JP66_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499734.1">
        <property type="nucleotide sequence ID" value="XM_050643777.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643777.1">
        <property type="protein sequence ID" value="XP_050499734.1"/>
        <property type="gene ID" value="LOC126880097"/>
    </dbReference>
    <dbReference type="GeneID" id="126880097"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="560" mass="66058" checksum="D6D5176D98652736" modified="2025-10-08" version="1">MFPIYFFHNMSAMEFKDEIKEEFFEYDQKDIESQLSTSIDLEHFKNESEDNSAMEVKPEIKREFAENDQGYIENQLCTSVELEHFKNEPEDNSEMELKARVKEECVEGSQGYIESQLSTTPDLEDSINKPNEDNSGFSHNTMEIMESELACTTKQQTSANTEETALKNSIRKCKICFKPFNHAGSLKKHIKTHSRKKSHKCEICLKQFFNSNNLKTHLRTHIGEKPYKCDICFKQFLQTDNLKTHLRLHTGEKPCKCEICFKQFGQAGYLKRHLRVHTGEKPYQCETCFKQFGEASSLKTHLRVHTDEMPYKCEVCFKQFAYKQSLEKHIKVHIGEKPYKCKVCFKQFSEKGNLKTHLKIHTGERAYKCGICFKQFSQNVHLKTHLRVHTGEKPYKCQICSKQFKQESHLKTHLRVHTGEKPYKCEICFKQFGLAHELKQHLRVHSGEKPYKCQICFKQFKQESHLKTHLRVHTGEKLYKCEICFKQFGLAHKLKQHLRVHTGEKPYKCQICFKQFKQESHLKTHLRVHTGEKPYKCEICFEQFTQTSNLKRHLKIHTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUP4</accession>
    <name>A0ABM5JUP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501660.1">
        <property type="nucleotide sequence ID" value="XM_050645703.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645703.1">
        <property type="protein sequence ID" value="XP_050501660.1"/>
        <property type="gene ID" value="LOC126881426"/>
    </dbReference>
    <dbReference type="GeneID" id="126881426"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="532" mass="61166" checksum="3F2F4F99D44BD3EA" modified="2025-10-08" version="1">MNPLSQLLNSTDAGFSIKNNNNVVAKLNHLLYMDDLKLMASTRNQLDEMLKTVETFSNDISMHFGLDKCRILNIVRGKVQPGGFDMQNGQNIEAMGEEDMYKYLGVKQARKIDHKQMKTEITTEFIRRVKQLLRSHLNSRNLFKALNTYACSALSYSFGIVKWTKTDIEALQRKVRTHLTKAQKHHPKSAVERTTLPRNLGGRGLMDIGEQLDKQIANLRTYFQMQAETSTLHRAICAVDDTTPINLREPEMRINHLTKDEKLRAWMGKPLHGRHPNEVSQDYVDNIASNYWLTSGKMFPETEGSLLAIQDQVIPTRNYLKYIIKDPQVQNDRCRYGCQARETIQHLTGGCQAFAATEYKERHDAVAKILHQEIAIKLGLLQTDHIPYYQYVPESMLEDGNYKLYWDRTVLTDQTVAHNRPDLVLVNKLTRQTTLIDVAIPNNNNLRSKFTEKIAKYRDLEIQIRRQWRMQSTQTIPIIISTTGVIPKTLLESIKKLGLNEHLYKTMQKAVLLATARCVRKFLGDTPALKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVD8</accession>
    <name>A0ABM5JVD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501908.1">
        <property type="nucleotide sequence ID" value="XM_050645951.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645951.1">
        <property type="protein sequence ID" value="XP_050501908.1"/>
        <property type="gene ID" value="LOC126881589"/>
    </dbReference>
    <dbReference type="GeneID" id="126881589"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="603" mass="70430" checksum="60942A7FBD2FCB4E" modified="2025-10-08" version="1">MEIEQDASEKTCKIEIDEACDGPLDVFKIEITEEPKREPNAFDNPDFNKFPVNPEVEQVEYKFTLSEKKQTSSEEGCPHEEDKMKMMETLLSPHQGKYNGQQIEGKILIKNRKVGTGQKPYKCEICSKQFGDAGNLTRHLRIHTGGTLYKCDICFKQFTRAGSLKIHLRTHTGEKPYKCEICFKQFTYARNLKEHLRVHTGEKPYKCEICFKQFGDVGNLTRHLRIHTGETPYKCDICFKQFTFASRLKQHLRIHTGEKPHKCEICFKQFSQISQLKTHLRTHTAEKSYKCDICSNQFSEAGNLKLHLRTHTGEKPYKCEICFRQFTFASNLKEHLRMHTGEKPYKCEICFKQCSKSGNLKKHLRTHTGEKPYKCEICFQQFTQVGSLKNHLRLHTGEKPYKCEVCFKQFSQSGDLKRHLRVHTRETPYKCEICFKQFSTTGYLKTHLRMHTGEKPHKCEICFKQFSLTDTLKRHLIIHTGEKPHKCEICFQQFTQAGSLKTHLRLHTGETPYKCEICFKQFSRSYDLKKHSRVHTGEQPHKCQICFKQFSATGDLKTHLRVHTGEKPYKCEICFSQFSVKCNLKSHLRLHTGEKPQTCVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVL1</accession>
    <name>A0ABM5JVL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501980.1">
        <property type="nucleotide sequence ID" value="XM_050646023.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646023.1">
        <property type="protein sequence ID" value="XP_050501980.1"/>
        <property type="gene ID" value="LOC126881647"/>
    </dbReference>
    <dbReference type="GeneID" id="126881647"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid desaturase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="313" mass="36157" checksum="51585440DD37345E" modified="2025-10-08" version="1">MAALPPLSCSPRVKEEIVYPITCTVATNLLAPVKTEQQILENSMLEDDPNANCAVAAVPKEKSGPRWGPQHKGAQELANLYSKGKRTQEVICVGICLTLMVINFVFIVYYIHLEKLSTILVAAFCGIVTADFGSGLVHWAADTWGSVELLYIGKNFLRPFREHHIDPTSITRHDFIETNGDNFMVTIPFLGRMVWDFLTLSKEDVQIRFTWNCYIFLLAIFVAMTNQIHKWSHTYFDLPSWVIFLQEYRIILPRRHHRIHHVAPHETYFCITTGWLNWPLEKLRFWSTLEIIIEMCTGCKPRADDFKWAQKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JW53</accession>
    <name>A0ABM5JW53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050502168.1">
        <property type="nucleotide sequence ID" value="XM_050646211.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646211.1">
        <property type="protein sequence ID" value="XP_050502168.1"/>
        <property type="gene ID" value="LOC114327150"/>
    </dbReference>
    <dbReference type="GeneID" id="114327150"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768:SF3">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="178" mass="20298" checksum="636C95C096A446F3" modified="2025-10-08" version="1">MSTRLEVIYPDGSKYDHQLPSNFEDQVKELIAKLQEKLVREGAWIENKGASLTFHFREAPAHLREEMEREATKIIEAANFKSSKAHMAVEARPKVDWNKGSVALLLLEQKYRKNWNKEAKVIFVGDDTTDEDAMKALKGNAALFRIAKPCADTNADKIISSTEDTLKILKIVQKHFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWU1</accession>
    <name>A0ABM5JWU1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502406.1">
        <property type="nucleotide sequence ID" value="XM_050646449.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646449.1">
        <property type="protein sequence ID" value="XP_050502406.1"/>
        <property type="gene ID" value="LOC126881839"/>
    </dbReference>
    <dbReference type="GeneID" id="126881839"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046411656" evidence="1">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="242" mass="27981" checksum="AE720D670F2FC165" modified="2025-10-08" version="1">MHVNVLMGFLLFFVVFVSSAEEKKCRMCPLSKRFSPKIENEIESTYDETCECRIPLFYDEINKTCVNLKDCPIVKELNNIQENPLTIFSQVFDTEDFMSLLNGDAFILCKVALVDTGILTEEDMRELVDSKEGRIIKAALQQHIGSVFLNYSTITNIIFNPFVRKNPTILKKCGSDDMCITEYFIKRHQKLMKLISEDFMVNLSMGFNNLGVHLKECFEVECEEDECKFVKFILILLDSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYM2</accession>
    <name>A0ABM5JYM2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Growth arrest-specific protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503030.1">
        <property type="nucleotide sequence ID" value="XM_050647073.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647073.1">
        <property type="protein sequence ID" value="XP_050503030.1"/>
        <property type="gene ID" value="LOC114344544"/>
    </dbReference>
    <dbReference type="GeneID" id="114344544"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21204">
        <property type="entry name" value="CH_GAS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF13">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="47"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="303"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47196" checksum="71927AEFA9F839ED" modified="2025-10-08" version="1">MSYKQNFARNRNSWGPISVASPGFYRSPEDDDDDDDELKAIQARQLDPLKEDLADWLNKTLGIDYINKDNFLDELDNGVVLCHLAQIITEGVKKAIDKGLVKGPLPKIRGKCFEKAARGSFFSRDNMENFIRFCRSLGVHENLLFESEDLVLHNQPRNVILCLLEVARIASKFGIEPPGLVQLEKQIAEEERDSFDSRLSSLLTWQFPSITSPSPNYSKMKQSHSAGAISSVLDRWNTHHVVLVEQTNALNSLPVVNTSGASDGVPSDNTEDEEWSRGSGEDPDLDVTPPMRPSSGDSGGANTPSPTPTNELDRKVQLAARLMQKNCNCSSGRCEKLKIRKVGEGKYNIAGKNVFVRLLKGRHMMVRVGGGWDTLDHFLLRHDPCQVKVVSRESQDRPSSASKYLHIRAKYRSPPPRESITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYR4</accession>
    <name>A0ABM5JYR4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503070.1">
        <property type="nucleotide sequence ID" value="XM_050647113.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647113.1">
        <property type="protein sequence ID" value="XP_050503070.1"/>
        <property type="gene ID" value="LOC126882272"/>
    </dbReference>
    <dbReference type="GeneID" id="126882272"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047001615" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14437" checksum="0F2704FAA721A767" modified="2025-10-08" version="1">MGSKDLIASVLVLVGYISSQAESNKLELNSSMTLVTCMEEAGMTFDQFKEQLKSNGHDALCVLKCSYEKTGALDKDGNVDPGVLWAHLVKHGLDDTPNIKNKFTECMKSAGKILTCDDAVKFASCFDDIFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZN8</accession>
    <name>A0ABM5JZN8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Furin-like cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503406.1">
        <property type="nucleotide sequence ID" value="XM_050647449.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647449.1">
        <property type="protein sequence ID" value="XP_050503406.1"/>
        <property type="gene ID" value="LOC126882483"/>
    </dbReference>
    <dbReference type="GeneID" id="126882483"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Furin-like cysteine-rich" evidence="1">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="132" mass="14798" checksum="F02EDDB1D440B761" modified="2025-10-08" version="1">MPNNIGLVNLLSIARGQVRIGKSPNLCYVESINWKKLGVEKNVTTYLIASQDKCGKCPSACKGACWNATHCQQNLSNDHCHKECWGCYKNYSARHCIVCRNYDDNGLCVKSCPPDKLDSSYLHVTGDWYCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K113</accession>
    <name>A0ABM5K113_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503874.1">
        <property type="nucleotide sequence ID" value="XM_050647917.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647917.1">
        <property type="protein sequence ID" value="XP_050503874.1"/>
        <property type="gene ID" value="LOC126882824"/>
    </dbReference>
    <dbReference type="GeneID" id="126882824"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="241" mass="27940" checksum="5BFACEDEBA552E77" modified="2025-10-08" version="1">MCCAQTREKCKAFLKTQGDNVVTEIRDEHNHSELNEDALNRQMLSNSLKRKAVEDVGERPIKILQKELRNGDISTLTTKDVALVRKNMYNARRSLLPKLSKSMEETHDILKTFPVKTNKNEDFLMVNDIENQIIMFSCSSNLEFLADLDTIYIDGTFEYCPKFFKQMFSIHGLKEDHYIPLVFFSLPSKQKHTYTLALKYLTEQVEKCNKKLALRTVFADFEEAIQQSVTEVWTHVSLKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1R7</accession>
    <name>A0ABM5K1R7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504132.1">
        <property type="nucleotide sequence ID" value="XM_050648175.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648175.1">
        <property type="protein sequence ID" value="XP_050504132.1"/>
        <property type="gene ID" value="LOC114325498"/>
    </dbReference>
    <dbReference type="GeneID" id="114325498"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF2">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047400150" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="176"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="330"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="467"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="624" mass="70821" checksum="7FC20782AF74E0F8" modified="2025-10-08" version="1">MNNSNAMKLPLYMLIIESTLIAAGVAVHPGCECIIFSKMYGKEKGFFKSPDFPKPYSPNIDCLLYTFIGSTDEIVELSFSDFDLHKTQGNCILGDYLKVFMHLEDVSVNEYTPWEILMCGGYADVPNILYSSGSVLVLEFHSSPYTANSSGFLGTFKFLEKRLFRTDGWKLPSTTCDYEFYSSDHSQLYGKFYSPRFPSSYPKNIRCTYKFQGRRKERIRIIFEEVALQKGDISCLNRADIIRVFDGSRSSDPSIILLCNEETQIEILSTGPDLFIEFVANSDNPGRGFKGKFQFQPSDNVVDSRSPGLPGPHSQSTETEPNVRETRSSCDVTISSDTNRNGTIISPSYPSPYPAKTTCTYEFQGRGKERVQIVFQDFSLYIPNANAKNCDNTDSLAVFIHIDGRIEKIDKFCGTTLPKPIMSNGPRLKLEFQSFYTSRYSRGFKSTYAFMENFGIKTGTQLSTYPCAFEFNSSELSEGFFHSPNYPGFYPRDTECHYFFNGNASERVQLHFYYFDVEGVLPCEAVSASDYVEFSNYLTRDRKFSRYCGQLKEFDVESDRKFFRVTFRSNDRLDGTGFNATFKFVMGKENHGKKLSTSVNATTFIKGTCLLVILSLISLTKINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K2F9</accession>
    <name>A0ABM5K2F9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050504374.1">
        <property type="nucleotide sequence ID" value="XM_050648417.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648417.1">
        <property type="protein sequence ID" value="XP_050504374.1"/>
        <property type="gene ID" value="LOC126883168"/>
    </dbReference>
    <dbReference type="GeneID" id="126883168"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="6">
        <location>
            <begin position="191"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="432" mass="47616" checksum="4D1EC8DBE7FF4A85" modified="2025-10-08" version="1">MAKQSYKVADMSLAEWGRKEITLAENEMPGLMSLRAKYKDNKILKGAKIAGCLHMTVQTAVLIETLADLGAEVQWSSCNIFSTQDHAAAAIAKRGIPVYAWKGETDEEYVWCIEQTLVFPDGKPFNMILDDGGDLTNLVHTKYPQYLTGCKGISEETTTGVHNLYKMYKEGTLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVCVVAGYGDVGKGCAQSLRAFGGRVLITEIDPINALQAAMEGYEVTTMEEASKEAQIYVTTTGCKDIIRGEHFLNMRDDSIVCNIGHFDCEIDVAWLEKNAKEKVTIKPQVDRYLLSTGNHVIVLAEGRLVNLGCATGHSSFVMSNSFTNQVLAQIELWTKPGAYSLGVHMLPKHLDEEVARLHLKHLGVKLTTLSADQAQYLGISAQGPFKSDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K501</accession>
    <name>A0ABM5K501_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505268.1">
        <property type="nucleotide sequence ID" value="XM_050649311.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649311.1">
        <property type="protein sequence ID" value="XP_050505268.1"/>
        <property type="gene ID" value="LOC126883656"/>
    </dbReference>
    <dbReference type="GeneID" id="126883656"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="37341" checksum="04C1438D2302EBA6" modified="2025-10-08" version="1">MSQGRKGLRNKKNEEDVEVEENVEVDGETQQAEQEQSVAPVLQETTGITQEQEENVNMTALIMTLSDNAATWFASIENDLDNLQTFENKFLNYYWGELEQARFREVLYFGKYNRNLSLNTVDYALKLITVAKYLEPPLREDETVLNVSRHFDADVVQTVTVQNIQTVDSFINFIQRVQRGYITSNNSKNRQSYNNNRYGSNSQNFNNNNNTSYERQGNRENFNNNTNDNRQERQGNRENFNNNNNYNRQDFNTRRNAQKYNYNRQVNYVRGQSCEDSQRNSTWQENMNSRSESSERHRELDPNDQTQSDNPNNPKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5K5</accession>
    <name>A0ABM5K5K5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505475.1">
        <property type="nucleotide sequence ID" value="XM_050649518.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649518.1">
        <property type="protein sequence ID" value="XP_050505475.1"/>
        <property type="gene ID" value="LOC126883842"/>
    </dbReference>
    <dbReference type="GeneID" id="126883842"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="139" mass="15527" checksum="12319510745E71C9" modified="2025-10-08" version="1">MQIDSTNSEKQTAFMSKSSEVSTKHVKKVNKKNITCFRCKQKGHYMNKCPSANNNAFSATFLSGNFKSTDFYVDSGCSTHLTARKDWLTNIRDASSSNITVANSESLEVKCAGDMMVTTIVDKKRLEDELACLLYDQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K739</accession>
    <name>A0ABM5K739_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506002.1">
        <property type="nucleotide sequence ID" value="XM_050650045.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650045.1">
        <property type="protein sequence ID" value="XP_050506002.1"/>
        <property type="gene ID" value="LOC126884187"/>
    </dbReference>
    <dbReference type="GeneID" id="126884187"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046255326" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="512" mass="58954" checksum="E1C6B3B9D2B75D93" modified="2025-10-08" version="1">MLRQSLLFFTFVLSIAFSKRPSVLFIIADDLRPSLKSYGDKEAYTPHIDKLASNSFIFKNAFAQQALCAPSRNSFLTSRRPDSLHLYDFYSYWRHTVGNFTTLPQHFKENGYYTYSVGKIFHPGKSSNFTDDFPYSWSTKTFHPKTEAYINAKVCIGKDGQRHMNLICPVIPMYQPGGTLPDMESFAEAVRFLKYKDQITGNRPYFLAVGFHKPHIPLKFPRWYLKYHPIENVSLPTNRWRPTSLPTVAWNPWTDIRRRDDIIQLNVSFPFGPMPDDTIKAIKQAYYASVTYIDDLIGNLVSYVDKDTIVVFTSDHGWSIGEHGEFAKYSNFDIATRVPLLIRVPGLSTTKVIVEKPVELVDLFPTLVDLTQVSSPLKTCPEKASEMLCTEGKSLVPFMVKKKGHKQLSSLSSFSQYPRPGPFPTSVPNSDQPKLKDIKIMGYSLRTEQYRYTEWVDFSKDTFKPDWNTVYGSELYDHAIDPFENNNLVDRDELKNVSKCLRDKLILGWRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7T7</accession>
    <name>A0ABM5K7T7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506252.1">
        <property type="nucleotide sequence ID" value="XM_050650295.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650295.1">
        <property type="protein sequence ID" value="XP_050506252.1"/>
        <property type="gene ID" value="LOC126884365"/>
    </dbReference>
    <dbReference type="GeneID" id="126884365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="77890" checksum="FD7F14BB3AFF91F6" modified="2025-10-08" version="1">MEKKEFSSYVTYSHPYTTAEGIKKQSYICHRSGFYVKKGKDMRYLKTKGSRKINGICPSRLKVCILPENGNVKINFIQTHIGHDNDLGHLNITKNEKIEIASKIASKIPLVCILDEIRDSVTNNKLERMHILTRKDLHNISQTFNLNSDGIRHKNEVISIESWIEEAKNSGIILYYKPQGALCNDFPCLKNEDFLLIVMHPGQLEVLDKYSEDVICIDGTHGLNAHDFELTTLLILDDMREGFPCCFMIGNRSDEEIMTIFFMKIKENLGRVIKPMVFMSDMAQYYYNAWLQIMTPAKFRLFCSWHVDKAWRKNLNKIDGQEQKVIVYKQLRTLLQETDVTSFRDMIQNFQISLLSSGNTQEFGQYFQKCYLHNMESWAYCYRLHAGINTNMSIERMHQTIKYLYLNGRQVRRLDKTINILIKLIKDKLFERLITLNKGKISSKLRELRKRHKTSLNLDMDTIVMSEMGWEIPSSSTNDIYLVQKNKPSCDCRLVCDLCQSCLHSYSCTCLDNSIRWNMCKHIHLVCQFMKGHQIQDTNADEEHIINTDEVKIKQATEQAKFVEFVSKSCNINQEKTSKQLEVEKQKLIEIQTQIIQNITTFEQLEAFKSITAPLVPTLRTLAEHSGNEFNIVALSHGTQNIPHNKKVVAQKRLFSTKKKTTVKKKAVIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K849</accession>
    <name>A0ABM5K849_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 25</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506362.1">
        <property type="nucleotide sequence ID" value="XM_050650405.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650405.1">
        <property type="protein sequence ID" value="XP_050506362.1"/>
        <property type="gene ID" value="LOC126884470"/>
    </dbReference>
    <dbReference type="GeneID" id="126884470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.30">
        <property type="entry name" value="Mediator complex subunit 25, ACID domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021394">
        <property type="entry name" value="Med25_PTOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038196">
        <property type="entry name" value="Med25_PTOV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021419">
        <property type="entry name" value="Mediator_Med25_VWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12433">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12433:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11232">
        <property type="entry name" value="Med25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11265">
        <property type="entry name" value="Med25_VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A" evidence="12">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med25 PTOV" evidence="11">
        <location>
            <begin position="478"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="748"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="898" mass="97607" checksum="30957D9AEA789B4A" modified="2025-10-08" version="1">MVVCSVEHGVQADVIFLIEGTAVNGAYINDIKTSYIIPSLEYFNQAKIDDANYVSENANSMYGIVVFHAADCLPHLSTDTFGPFISPTKLLSAVDKLDLAGGKGESHSNIAEGLATALHCFEELQQKRDVTTLVQKHCILICNSPPYALPVLESHTYSGKTAEQLAVILQEKNINFSVISPRKIPSLYKLFEKAGGDLSSSQTKNYAKDPRHLVLLKGFSLKERSVSPPPGATTTSQTQITNTGMPTMTSLPSPLQGSDSPIPGTTQPNSNILVNTTAGVGANVGQNNVYRPQGTQGMNMPPQKGVGVVNVPGGRMMANNQISMMQVNAPPGYHATGHVNINRTSPHWPMAPPIQQVRPYIPQTNQQVNTTQGSALIAQLTQPPSSISGTGVNQFGQMTTNSPINKINMPPQSNVQTSMPQNQIAIQTSMAQVSQANAIATSQAQISQNMSQGVQGVQNVQGVQGVQGVQGQQQPIRERHTIWQGLLEWIEKPKNATEQKTTKHVPCQVSANSKDGEPELKADGWPQKLIMQLMPKQLIGNIGGAYLKNSKSVLFHPQNCDALESLTKVMSSGFAGCVHFTSVAPCDIKVLILLYTSDKKAYLGFIPNDQVAFVDRLRKVIQQQKSTQQMRQGGPGAPNINPQVGQVGTSPQMSGANPISSQNTQQNMLISPTNSISMGGGQITQNVSSASQPVQGMGGIINQNVSQGGMRPNIRMPGIQQGNNNQPNMMQNPVPSNAPLENQLEVERRHNLEKINQLKQTLEAAQQQERQYKSQLEKISYMKTSQLEQALQAAQQTEMHYKMLENQQRQQIATQGVQGAQQAATAQPQQRLMRPVMSNNPGLRHLLQQQPQYRQLINVAPMGGNGPRNQMGQQMQNPSGSQQNTFDEVGNFDFNNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K855</accession>
    <name>A0ABM5K855_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506368.1">
        <property type="nucleotide sequence ID" value="XM_050650411.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650411.1">
        <property type="protein sequence ID" value="XP_050506368.1"/>
        <property type="gene ID" value="LOC114343614"/>
    </dbReference>
    <dbReference type="GeneID" id="114343614"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047006591" evidence="3">
        <location>
            <begin position="22"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="610" mass="70878" checksum="D03CEAF7C643FC4E" modified="2025-10-08" version="1">MFLKLVLMINILFYLQILSNGQHADKHRCVIEHEKGERIQGNLVLFFPHTYLLYCDNVWRDTLDFLSIYARHLQRIVIEHHNIPIIWPGDLADLECNSVAVKQNKIEAISVNAFNSSMIETLDLSNNKIKCLFEDQLAIENLLHLSLQNNRLVYIEKNAIPSTVTTLNLRFNKLSSFESPSNVEELILSHNKLLTLDLSKSLLLKQLHLDYNELRRYDFSGLTQLTLLNLSFNGLQYLNRDKFLNMNQLFELDLSNNYLKDIDMLENTFPKLAVLKLNDNLISRFEDILQSIGTLMEPDVSGNIIEHFNFSNLGKVWRLKMNNMKLTSLDPESLFNMNTLYEIELSNNSLSTFNSNLYIPTIWRMDLSRNDIRRIDNNFGNFKALGSLDLSYNSISYFNVASNNLDKLWKLKLNNNKLGRIADRNVPNLNFLLMLDLAFNNLKTFMISPNKLKRLRLLDLSSNSISVYDEKLVNNLQGLRFYNLRNNFISEFPSSAFYSQNKLYYLDVSFNVITSMKYRDRENARSNIRTFNIFGNPLNCLHQRQIEAFCLRNNILLNICDVANGKSPICVDYKCDCEFIYNELTEQFLKFINKPKVGNCSFSVLAHNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9U5</accession>
    <name>A0ABM5K9U5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506962.1">
        <property type="nucleotide sequence ID" value="XM_050651005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651005.1">
        <property type="protein sequence ID" value="XP_050506962.1"/>
        <property type="gene ID" value="LOC126884779"/>
    </dbReference>
    <dbReference type="GeneID" id="126884779"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="100" mass="11215" checksum="C3B74B690576DDD2" modified="2025-10-08" version="1">MVCDKCQAKCGKVITPDPWKTGARNTTESGGRRVNENKALTSAKNRFNPYTTKFETCRICRQKVHQVGSHYCQACAYKKGICAMCGKKIISTKNYRQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAC3</accession>
    <name>A0ABM5KAC3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507137.1">
        <property type="nucleotide sequence ID" value="XM_050651180.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651180.1">
        <property type="protein sequence ID" value="XP_050507137.1"/>
        <property type="gene ID" value="LOC126884870"/>
    </dbReference>
    <dbReference type="GeneID" id="126884870"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="331"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="823" mass="94338" checksum="041E13F2A1ABDF27" modified="2025-10-08" version="1">MVNLALQYLRLATQRSNIKLDIWFISRCLHNKVFPTFCRVRTSNNVHPNIRNAMQTKLMKKEICKHSKLNYIDCKLKVTYDSLLETLHYINLNTFLSDVQDKVDRSHSVKFNRVNNKLQHLVNNKIRLDQQKASHNKSFSNFRFHPRIKNLSNVQFSDDELKLLNLGLKHSIPTNLSIRDLESLSIETDTVIQNLSISLTQKTSIRNSCIQTINKFKTKLLSNNNSSISNINSSSTSTSSSSFPNFSFNKSKSLLSTLKSIKNKIKNQHLIFSKADKGNCLVILDQQLYIDKVTSFLNNNNFNLLPVDPSKSFVSKMKNNLKQFTDFFSEYEAPYTKIPSNPLTPRLYGLPKIHKVDIPIRPVVSFINTPVSILSKFILNIIKNFINFTPQFTVLNSRQLVEKLQLVNLNPNIVMLSFDVSNLFTSVPKNESISLVNSLLLNNSVTSTTTSSIINILKICLSQDYFVFNNNFYQQPDGLAMGSCLSPFLADVFMDHLESNHITKNPEILHWFRYVDDILVLISGNSDSAHNLLHKINLIHPKITFTMELESSNSINFLDISITRLDDHFNFGIYRKPTQTDHVIHSTSNHPLSHKLSAFRSFIHRLNSIPLSTPEFNKELNIIKQIAVNNGYDPDIIHKLQQKRELKLLQQSAFSSSSTTTPIYASLPFNNSKLSERVKQIISNSCDNIKISFKVNNTLNKSLTNTKDPIHYMSRSGVYRLSCSDCDATYIGRTYRSLSTRSAEHSKRDTTSAFSHHLKVNKHELKIPDGVQLIHNIQQKNTLRLDLYEDLEIVKDLKKSPNCVNRQTSLNRNFVPIHRQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBD4</accession>
    <name>A0ABM5KBD4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507497.1">
        <property type="nucleotide sequence ID" value="XM_050651540.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651540.1">
        <property type="protein sequence ID" value="XP_050507497.1"/>
        <property type="gene ID" value="LOC126885113"/>
    </dbReference>
    <dbReference type="GeneID" id="126885113"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40903:SF1">
        <property type="entry name" value="HYPHALLY REGULATED CELL WALL PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046845603" evidence="1">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="313" mass="30029" checksum="661DD59D5C06B3DE" modified="2025-10-08" version="1">MKPFLIGTIVLAVAAVATCGEATKKKNEKRGIFSSDIGSGYGGGHGGGIALELDGGHGLGGGSLGGHGGSISLGGGYGGGYEGGLGGGLGLGGGLGGGGGGGATVTTINRAVPVPVPQPYPVTVNRPVPVPVPQPVEVPVPRPVQVPIPVAQPVEVPRPYPVVVNRPVPVAVPTPVRVPVPQRVAVPVPQPYPVTVPQPVPVRVPQTIVVPVAQPIVVGGGGGGLGGGLGGGLGGGHGLISSGLEHGSLGGSYSLGGHGESLGGISLSSSHGYGGVYRGGSSIPIGKSISFGSGGHGGGATSYSSVSHGHSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCG5</accession>
    <name>A0ABM5KCG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507882.1">
        <property type="nucleotide sequence ID" value="XM_050651925.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651925.1">
        <property type="protein sequence ID" value="XP_050507882.1"/>
        <property type="gene ID" value="LOC126885367"/>
    </dbReference>
    <dbReference type="GeneID" id="126885367"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="615" mass="69086" checksum="7F4FF5B977C5C2D3" modified="2025-10-08" version="1">MALESETKRRTVLRPAFTIAANVLDNLLSETVNTRPWQQISVQWELLQVKYNELCVVESAVFEAMVEKASEAELISEIEAKDRYSTRYYELKCKCDDRPSLVSSESSNVKGKRSFKLPPIEFKKYSGDLIGWLPFWSQFKVVHDDLSIDLNDKIAYLRQATIDGSKARRLVESSPAVADNYSKIIKSLKSRFGREDLQIEVYIREILELILSRVSSSSCNVSALYDMIESQLRSLETLGITVDKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEESAEVTTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKYKSNNLVEKKNIKLPKQGTDLPSATAAGLIIYEVGRCIFCEGQHDSINRFKAQKLSMEQKRRTLTEKKACFRCLKVGHSSKKCRGRLNCILCCKSHVALICPDLPVNKIDTLTSSISRSEENRTGDQTLANLNNTQRTAQEMSFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALYQPQICADVSPVYHGPWVEELSDMNISLSDVVHIAPIEILFGADVVFKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVESYSVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCS8</accession>
    <name>A0ABM5KCS8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507998.1">
        <property type="nucleotide sequence ID" value="XM_050652041.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652041.1">
        <property type="protein sequence ID" value="XP_050507998.1"/>
        <property type="gene ID" value="LOC126885468"/>
    </dbReference>
    <dbReference type="GeneID" id="126885468"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="183" mass="20863" checksum="2C6CDF4BB457C633" modified="2025-10-08" version="1">MTLWSRQALRKVRSQRRRVLRNNRLLYDLVRCFDRINTQTALNTFESKTETQKRKLAHLITQQLPKPRTLKPTTVVHNFSDTPISTIATQALAKGFDYSVTPSHIPIETIICQTEEAISHLPSEDAEIVRQDVARVLRNSKPPTPNISQSERKVLKELQANPDLVILPADKGNATVILNTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE87</accession>
    <name>A0ABM5KE87_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508473.1">
        <property type="nucleotide sequence ID" value="XM_050652516.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652516.1">
        <property type="protein sequence ID" value="XP_050508473.1"/>
        <property type="gene ID" value="LOC126885737"/>
    </dbReference>
    <dbReference type="GeneID" id="126885737"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF19">
        <property type="entry name" value="GH19849P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="387" mass="44486" checksum="BF640DC37B29CD84" modified="2025-10-08" version="1">MGFKKRVKSLVTCVNFLLAQVFTIRMTTWLSLVVPLVYLWCRCKAEDELVSVVEIFRHGDRTPAFFYPNDPYQDPKYWNGLKEGDLTEKGSQQLYNLGQQFKDRYKDFLGNAYNPDEIIVMSTHMSRTENSAKSFMSGLYGGIEIPIKKETAVANQIITCLKFDYLYKRSELSDPDIVDINEKNKDLYQYLSNHTKLPVGGLFRASGVLDTLKIEQDANLELPEWANNVMGDTMQRVSKTAAEFFCYTKEMQKLGLGSLMNHIIENFDNIISGKKEAKTLIFSLHDLNLICFLQSFKYPEIAQPGFASSIFFELKKSKTNGPYYVNTFYKPSVEQTPIPINVAGCDLDCDLDEFKNIFRDLRLSAGQWYSECYAFGLFDKLFPTKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KE89</accession>
    <name>A0ABM5KE89_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050508516.1">
        <property type="nucleotide sequence ID" value="XM_050652559.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652559.1">
        <property type="protein sequence ID" value="XP_050508516.1"/>
        <property type="gene ID" value="LOC126885818"/>
    </dbReference>
    <dbReference type="GeneID" id="126885818"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="59"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="179" mass="20128" checksum="591412C7C54216C1" modified="2025-10-08" version="1">MYTFKISKQTISKCVAEVCKALIDALQDYVKMTKTNESWYFIAKQFNDKWNFPNCVGAMDGKHISIQAPINSGTDFFNYKSFFSIVLFAVVDANYNFIYANVGCQGRISDGGVFNDSYFKECREENTLNLSPACSLLGRSTDVPFVFVADDAFPLSTNIMKPFAGHQEKGSKIEYSTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHP6</accession>
    <name>A0ABM5KHP6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509737.1">
        <property type="nucleotide sequence ID" value="XM_050653780.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653780.1">
        <property type="protein sequence ID" value="XP_050509737.1"/>
        <property type="gene ID" value="LOC126886757"/>
    </dbReference>
    <dbReference type="GeneID" id="126886757"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="396" mass="47242" checksum="7243C3B4A26999BB" modified="2025-10-08" version="1">MKMTIYNTIFFGVWPLVFDQKPLYRKIYNIYSWFIFLIAFLYVTTEYIELYLMIKKNLDMINFTKSAVLASTYTMGLMRVQAVSTKSVQELIKRIHVRERQIFESEDEGITKIYKERSRINNKFNFYYMMVNYWDTIVYLYIIFPLFYPYQEIYDPATNQTKLHKDLPISSWMPFDVDENYYNALLWEDIAATCCAVYNYGTDIFFFSFISYVMGQLDILNYIILNFESYKEKIKDQIECDDEKAEFVTMQLCIKEHQRLMGFVNDYNNAMRSVMLRDFLQSSLQIALLCLYVLFEVDMLAMTAGVGFGFILLCRLGVYYWYANEVMMKSFDLVDAIYTVKWYEKSPRTKSLVNIFMLKCNQRAGLQIGTLTVMSWNIFFGILKSAYSFMTFVWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJ93</accession>
    <name>A0ABM5KJ93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein GVQW3-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510282.1">
        <property type="nucleotide sequence ID" value="XM_050654325.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654325.1">
        <property type="protein sequence ID" value="XP_050510282.1"/>
        <property type="gene ID" value="LOC126887019"/>
    </dbReference>
    <dbReference type="GeneID" id="126887019"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18056" checksum="83C35F0E8D19C6BF" modified="2025-10-08" version="1">MGTKKSDKSRKSVTVDLPTFTREQKIIATVWYHERAFTGMSYEELKDNFMIRFKLKYPTRHTLREWDQQLFAEGAPLKKKARLRTSLDRLIYVPYVKESFIRFPDLTVRGRADMLGMSVGTLNNILKNDITEGEVASLKNTTANSTSTPQGDSKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJF5</accession>
    <name>A0ABM5KJF5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510341.1">
        <property type="nucleotide sequence ID" value="XM_050654384.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654384.1">
        <property type="protein sequence ID" value="XP_050510341.1"/>
        <property type="gene ID" value="LOC114336861"/>
    </dbReference>
    <dbReference type="GeneID" id="114336861"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="546"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="662" mass="77487" checksum="9094D3E0654CFC8C" modified="2025-10-08" version="1">MNRLDKTRTINVYKVVEDITISVFQYEFSSITKELISKKRVPSLVGTFDPNALDTPKDGSKLSFRCFDKDESVTKWSKVKESSEAVMYVNSALNIPTMIRCQNCEVIFPTKYQYQRHQCQFNAEKVVLKSEGKEVYIENRVTYICEICNKEFVSESNLQRHQLSHKNAQENVCEHCNKQFISDNRLRIHRENHCKKSGDISKFYRSDISVWKCNKCQQVFSSSLAANYHSSSCTEAVKPNHENNQSTDTADPAESTPNADIEKVLTEILLQCEFCNRIYTDKNILLMHQNMHTTDKNYECVKCSKVFESYVLAVQHWMKKCSDYMSPFYLPKLVYCEFCDRTFKSHELLYTHKVKRKHYTMKIQTTNPDESSKEQVTHLTVSNLETNTDKQILDKLVEDVFKTLNVPSNTINGQMEANKENIDGDTPVNVGEKKKRGRKKKSAQDSCIRSKKIMAAVDDRLKYQCERCVHVFDTVVDLEEHRRTEHTSNFTCDICGQVLHSAKDMVIHSRTHQKLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCNVCNKCFLTGSVYYQHRLIHTNDRRYVCDICDKRFFRADALNNHRRIHTDERPYPCQVCGRKFRQKGDRNKHLRTQHLDTLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJS6</accession>
    <name>A0ABM5KJS6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510460.1">
        <property type="nucleotide sequence ID" value="XM_050654503.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654503.1">
        <property type="protein sequence ID" value="XP_050510460.1"/>
        <property type="gene ID" value="LOC126887142"/>
    </dbReference>
    <dbReference type="GeneID" id="126887142"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="381" mass="44118" checksum="6653497ED6CB7A0E" modified="2025-10-08" version="1">MYSVIEFKQEEDGGGLSIVNSTWLTPRKTEVRWPPIKDNLQFKKVLRKLEPEIDETWKIYGVQKIFYSTDDFEKATNKLKRAEITSDLQTDLEDDNTRPRRKILKRKFSSDEDSNDQVSLFKPGKKSKQILPWPPPVGINKLYTNPRGSSQELESGTDESDPGIPSGSQFMKSISTPRDKLSFQISTPKSSSSFGRQEATEIQTPTLNESLNFDNSLQDTNGLKVLLKHILTIKEQNRKILNILEKSKPFENSDLPDDFKIKLPIESLQDLEELEIYLTEEENFNTFKSYCASISNLKDVTQKNNRILRSLLTDNIAKHFNYFGNNRRQDRVSNKRPFNQLRLNKVVLDAVKQGTDFTTHEVENAIKRWLKHAPNRNKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLC9</accession>
    <name>A0ABM5KLC9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511002.1">
        <property type="nucleotide sequence ID" value="XM_050655045.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655045.1">
        <property type="protein sequence ID" value="XP_050511002.1"/>
        <property type="gene ID" value="LOC114336468"/>
    </dbReference>
    <dbReference type="GeneID" id="114336468"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22718">
        <property type="entry name" value="FHA_SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="424" mass="50546" checksum="59B4EB88762B0712" modified="2025-10-08" version="1">MSSHRKKKDTESSSASDSSKYSSSSEESTKKYKSKKHKHHSDSDDSDSDHISKKRYQDSSDDSDAHKTSSKKSTNKTRREGDSNLRKEESSSKQNWDKKESHSKDKYERKVYDSKEKQNQNRRDARDYNRDKYDSKSYNRDRYDDRDKYDDRDKYDDRDRYDDRDKSRYKDRYDHKGTQGSRSRSEEREKSKQFDNRRDQGNDRNKRREGFRRRRSSSFDHANARWGKPEDDSKQKKEPQQKDKPNFGLSGKLTEETNTYKGVVIKYSEPPEARKPRRRWRLYPFKGEKALQVLYIHRESAYLIGRERKVVDLPVDHPSCSKQHAALQYRLVPFTRENGSSGKRVRPYLIDLESANGTFINNKKMDPKKYYELFEKDVIKFGFSSREYVLLHENSKEDALDDDVKMEEEDQKDVKVKKEVKTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP26</accession>
    <name>A0ABM5KP26_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511950.1">
        <property type="nucleotide sequence ID" value="XM_050655993.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655993.1">
        <property type="protein sequence ID" value="XP_050511950.1"/>
        <property type="gene ID" value="LOC126888001"/>
    </dbReference>
    <dbReference type="GeneID" id="126888001"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="133" mass="15655" checksum="491771C5C5C092ED" modified="2025-10-08" version="1">MEVKQETNETTCKIEIETCGGDDPFHAFKIEITEEPKREPAYDTFDYLDFPVNTKVEQDEYKFTPFEEKQTTEESLSFGPQRRLKIQIKTGGLKHVVTSLVCTFTFFQQSKQNFKVDIINISRKYMYLTLQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPD8</accession>
    <name>A0ABM5KPD8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050512057.1">
        <property type="nucleotide sequence ID" value="XM_050656100.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656100.1">
        <property type="protein sequence ID" value="XP_050512057.1"/>
        <property type="gene ID" value="LOC126888081"/>
    </dbReference>
    <dbReference type="GeneID" id="126888081"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16849" checksum="5560F3E431FBEBE9" modified="2025-10-08" version="1">MKDEQNLLETEGGMRRHQSMQRLARDGMLPEHRDPAKVVQDEEGNLRITVKKTKPILGIAIEGGANTKHPLPRIININESGAAFYAGGLEVGQLILQVDGTRVDGLQHQDVARLIAECFARRDREEIEFLVVEAKKSNMEPKPTALIFLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPT3</accession>
    <name>A0ABM5KPT3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512203.1">
        <property type="nucleotide sequence ID" value="XM_050656246.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656246.1">
        <property type="protein sequence ID" value="XP_050512203.1"/>
        <property type="gene ID" value="LOC126888192"/>
    </dbReference>
    <dbReference type="GeneID" id="126888192"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="422" mass="49147" checksum="A7F92A844F99089D" modified="2025-10-08" version="1">MNSSQRFNQRRQTNLYHQSLVVIPPPPSKFSLSEWHLNNIFRDRICLDQQKLADSIIAENDRAIDEVQDRTDLNKREVDHHLKEKLTDVEFIQSEIEKQRKEVCREEENLQTYMERIKDCLEACQKHGLEIVRKCIILREGRIGIDLCFDDVDKELRKELSVLDGGISLLKRTLEESNEQIRRLRSTFYFMDRDLTDKSTTHKIDLLNSSLTNTSLNLSIYHGFTPLDPANITLQEWEKFTADSIAKAAKEIACARQLRSYVDILLKQAIDDMDMQCNATNNAFRRRIEELKHIKTRLEIQHSEIMRQSNEMTRSITKLEKALVEKEGYMALAHTRLGHRAQRPGVELCKDLVEIALVNEVAELRGNCATLQQKLAESQASLRYLLKTQIQLEEDINIKTNSLKIDEVDCMSLRQGMDYHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT53</accession>
    <name>A0ABM5KT53_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050513367.1">
        <property type="nucleotide sequence ID" value="XM_050657410.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657410.1">
        <property type="protein sequence ID" value="XP_050513367.1"/>
        <property type="gene ID" value="LOC126889285"/>
    </dbReference>
    <dbReference type="GeneID" id="126889285"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045010679" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="36"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="567" mass="63671" checksum="421B1DB56A5F89A7" modified="2025-10-08" version="1">MKLFIYCGLLVFLVLSFTVCGVLTDSANELIVDLVTPKGQISGHTLQSYNGNEYYAFQEIPYAAPPVGDLRYQLPQSHPGWTGVLNCTNNTKVCPQPQSTYLDQDEDCLFANVYTPVKPGSNILLPVYVWIHGGGYAVWDGGFQRYNPSYLIDHNIVIVTFNYRLGALGFLATDDCVIPGNLGLKDQNFLLKWVSENIHLFGGDSSKVTIGGESAGASAVADHILSKMSTGLFRGAIQESGSAINYFNFVPSPSVYAYKLAQVIDNSINPQTTNTSVLLDFLKKAEIGDLVAASLKVPAVATGGMLVSDLVWAPTMENSCTAEPFLSKPMHEAFIKGDFNRVPLLTGFCSEEMLYFSPPSLTTIAFKVPTWEAFNKLAENLDNNIEDIAHVELDVVHSKRAKVSEEIRRLYTDSSFADDPYAYIRISSDLYLIQGIVRQAEIASKFIPVYMYEFDYAADNTFPFPGAQHTEELRYMWGNVEDLPFNNTFQPIMKERMCTLWSNFITYQDPTPSRDRKLLHLKWPTVKPNSTNYVSINKKFRTYSNPRRYNHIKSILLKYLQNPKIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXK5</accession>
    <name>A0ABM5KXK5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514924.1">
        <property type="nucleotide sequence ID" value="XM_050658967.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658967.1">
        <property type="protein sequence ID" value="XP_050514924.1"/>
        <property type="gene ID" value="LOC126890119"/>
    </dbReference>
    <dbReference type="GeneID" id="126890119"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57752" checksum="D9CA24266B94B05B" modified="2025-10-08" version="1">MTGIHINFQNCRGLNTKTAEFYKNCLEGNYDVVVAVETWLREDMVDGELIDINVFNLLRSDRNQEISGKTKGGGVLMVIKKEHKILKVTQHCSSFEILVADLKVNNKLSIKLIGVYIPPDCKLHDYANCFELLQTHITDINNTFIFGDFNIAEIKGTENLDFTNGSAKFKSMIEFLNFNSFLLYNNVKNWQGKTLDQVVASADNINSCKVCQEQLPLVKEDRLHPSLEIQLSFTVSSFRQTDKLVGNRFNFKKANFDLMCDLMRNMTWEAVTEEIEVDKALDIFYSKVLNIFEGSVPQYNIYKNYSNFPKWFTPDIKKLLKQKNNFRKLRHVSIYFNNQFIETRKKLKSLINIEHRKYIRQIEENIENEFNNFWNFINNKNSKSNQTEIFYFGGKEINQSDTANEFAKYFESVYSTDISSYNTNFTNIVSNNNVLNLPSITSVDYDNAVKKLKPKKAAGEGEIVAVERGIKTLINASTERADEFLEFLKEQKSVTIHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXN4</accession>
    <name>A0ABM5KXN4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514953.1">
        <property type="nucleotide sequence ID" value="XM_050658996.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658996.1">
        <property type="protein sequence ID" value="XP_050514953.1"/>
        <property type="gene ID" value="LOC126890146"/>
    </dbReference>
    <dbReference type="GeneID" id="126890146"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134267" checksum="1026F50A4C705430" modified="2025-10-08" version="1">MNSGPLPPVPGLIPISALRKRPPSNNNIDGNSDGGLPECAPCASNREVMGEQRPRRRSGNQPAVELIDNAGSRGSSAAPQALLSRKVRPERHRKSDRRRERHKLTRTRSCSKHSKSREINSEPPPVPINPRVNPIFVWVRQEDTRIVDVKCEDYDKRNRIVLTKTAQGWRAIPRTETLVPTLKEAVKDHHHHHKNKRSRKNKVRRRSTGVQVCSDIEQDYEEPEQLEPECDKKFDDKQIVSSPPWMSSDNVNIESLLPSHTIKVKRSTSPNHSPKQDSNVNSDVTDCTQTPTIKCSADKICDVSPLDNLLAVAELEFKQQIESEEWNKTTQDEPTEDTIVTFNNFAQSDEDKEFMKNLETLNSLIDSEKSKLDLTQNVDDSIEPKSEECDYNDDDDNNLAMDDILSRLEQSLRSPENTEANNCDTNTKTKPREDKKEHTDSDNETDLKSVPDYEHYFEETDPKIEEQKVDTEVENIKQEPEPIEIIDLVESSTNDDEEDETPTDLSIKVSEQCTNIQDDVSNAEEPTDLSVPKACLSPRPPSQNSETIQSPQPSGIPAVPQSPDIVSTTVNVSNKTKSIFLESLLTNTTKKLALNSEVTITAQMEPLDLGKCRKSASPTITCSEEINSSLSQLEPPAKKIKSVDITLKNLLDAECQNTNTEKKNAEKNMSTETPKLLELLQTESEVEPLIQLKQLLSDPTIDVPDPILVPKERFSQILLHPGSEIPKLLKERPELRLPQALAYPHIMQDPNMLVINIHHLESILCNKNSLQKGNKPSSEVKAQDKQEKQSDKASTETSQATSAATKKKPNESTSKLSAEAQTKIFNELANDINAATQAAFNQMSWFPYMNQFEAMTLPNNPEFMKMLNSLHLPFYLNQMNQMPEMFANVRPPASMGFPMPPPPMNYANPMEINMWQEAMLRAQLLKNRPVDNANNEQNMFANYFEKMNATNTQSSRASSSNNCMNPRAQNFNKPQSYSNQYYKNDQTSFHSPYSNHNYQAKSSHQINQKHATNQKLQSSMPAKSSTNFPHQMNHQNFANLYSQMTDMEKHQYMQNLNNVTAQQDQFHQNFQNFMRKDHVSQKQKMPSKSLSNSHQKSLAHQEAPHHREKSHPVVNDGTKPHTNQPIDLSGSMTGAKLKVKQHLIDPTNTPKLLKQHDDVPEVGSTTASIEEMQDAHKHLWHPLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXS2</accession>
    <name>A0ABM5KXS2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514996.1">
        <property type="nucleotide sequence ID" value="XM_050659039.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659039.1">
        <property type="protein sequence ID" value="XP_050514996.1"/>
        <property type="gene ID" value="LOC126890184"/>
    </dbReference>
    <dbReference type="GeneID" id="126890184"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118106" checksum="9568B3D1A4DA726F" modified="2025-10-08" version="1">FSSSGDDVQRSIELLDRVLSEFDDVENANQVQNIQQITTSTSTPQLRHLTSNNHHHNSTAPNSGATTTPDDESPSLGGHQSEDDGYMSMNGRKAKFNLSFKPLAEHHENPPPPLLSPHQLRSPTTPVRPGDPDDFPPPPEEAQRLIATLLPKVSPTHRPSKSRSGSVNSVTGGSGGRSHRSFPLTQLPPRMDTIPPPQRFQNDNSAAPIINGLPLDPVHTATQTTLPKTKHQRPFGWESNDFTLNPPPPPPGYRFGSLPYSHCVYPITSPTRMPPRTVPTAVERHREVKRHGSEDNLSSDLDETPALRPLSELADDEHFSDDSLEGILPPPPPPACNKRASIAWEVPLDDEALLTPGSTKVIGRRRRKSGSYSSTSSIPNRLKELEDWPDPPPCTTEDEVTSPFSDSDDHMMLPAELNSANISGNSTYIIRRGNKERKSLQAMGSSLTSNSSLNSRLSSELSIPASRFSGELSHRLSRELHTPSSRYSVDLGTSHSRLSNSPKSRLSLDLNNSRLLSQELSSSPSRHSVELCSSRSSTPSKYDLELRKHSTTFDNIKSLVREGVVQDLVSPKTETAKDFSPVISPIVRVVSLPSLNAEEFTPKRELDVTVEEEEEVESSQPSAEISPLRKIEQNISELLERRDIEVMQNDMFVLNGVDGLGREKKRAPSKPSRDFRHRNDLQKSNSHSEIQRTEEYYRQLLIDGGIPFPKRNGIQKSESAKEMLIAHREPRPLPTSTSADFPVRVEVLQHEFPPLPPSPVEEDEDEYTEILHPVHKSRADTLPNSNEPPAVPAHREPGSNSLKTRSMDVNYSRGRRTNFFTSSNRNIPSERRTLPTELQEKRRPFQKRASQQSPQEEHHLQTSCSLPETPIFARGCDIPRTPHRRAPDVPGGNQTAPRQSNTIGSLNTIGTTVSSGGYRRGLSQTGLEQAIVGAELLRLAGGPGRGWYPKQRHRRPASIEHLDRTAMGHNPWDTTSNRKPQTLPPNLTPKFFQRSPRDALRRVTSLLIKKGNNGKDTKKDKEVVSPTIHENANGEEVQKKKGFFKNFWKRSRHYSLEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYM8</accession>
    <name>A0ABM5KYM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chorion peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515294.1">
        <property type="nucleotide sequence ID" value="XM_050659337.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659337.1">
        <property type="protein sequence ID" value="XP_050515294.1"/>
        <property type="gene ID" value="LOC114328659"/>
    </dbReference>
    <dbReference type="GeneID" id="114328659"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF134">
        <property type="entry name" value="LD42267P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045077301" description="Chorion peroxidase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1391" mass="156786" checksum="410D826DAC6ED912" modified="2025-10-08" version="1">MDFILRLLPLTLLSVLVSPQSSLKPYEYNLTQYTKTLPDDLRPIVQKALSIERQATVNGKWSSSLCQQEESIECPPMKFRKPSGECNNVRHPKWGNRGQKFLRLLHPSYADHKSQPKQSVTSHSLPSPIDVASTLQSNPATKHESVTALLGAWTELLLHDLASTGNMKSQDCCSDNAKKHGECYGKLGNGQCREYMRTLPAVDMDTCEFGYRDQMNLATSFLDASAIYGNTDQQVENLRTYDAGLVNVSACSACRSNALYSAILKEHNRVAVNLAQLNKHWNDEVLFYESRRIVIAELQHITYNEYLPIVLGEEAIVHSELELKTHGRFSKYSSTQKVGVFNEVAISALPVLLSMLPISVMNETVETFAEMIDLLIQTPAQTPSVHIMVPIRREWDTASLFIHMGRDHGIPSYPKYLQYCTNSTSKKTPTFDSLKEFGIKDEYIKALKYMYRSPEDIDLLVGGLLEKPIPGTVVGSTFNCLLKKQFQLLKESDRFWYENDLPPSSLTDSQLKEIKKITVASLLCANTDDLERIQPKAFVQEDPYLNARISCDQHPLPQLSEWVEMDHMSDLSEDLLMDALQKAEKDLMDRRKMEYKVWSEVGGINPKSPQGVAAAFSKANKGALKLANTSLLFEFASNEIVNSLIHRRRRRQLFDNNAVADIFRDELSDALQQVDLGALIPPQTFDVDLQCDDNGPCDPTSPFRTYTGHCNNLRNPGWGKSLTTFNRLLPSVYDDGISKPRTIGVTGVGLPNPRVVSRVIHPDISNLHGRYTLMTMQFAQFLDHDLTMTPIHKGFHESIPDCRSCDSKRTVHPECNPFPIPSGDHYYPEINITSGERMCIPAMRSLPGQQKLGPREQVNQNTAFLDASQVYGENHCVLRDLKGQFGKMNATTHPVRGKELLPQSDKHPECKSPSGQCFIAGDGRASEQPALTAIHTVFMREHNRLSDLLRQVNPHWDEDKVFEHARRIIIAENQQVSYNEFLPRILGWNAMNLYGLKLLPHGYYKEYNPACNPSIVNEFAAAAFRIGHSLLRPHIPRMSPTYQIINPPILLRDGFFKVDIMMREGMVDEITRGLVSTPMETLDQFITGEVTNHLFEDRKTPFSGVDLIALNIQRARDHGIPSYNNYRALCNLKRATSFEDLAREIPPEVIARLKRIYPTVDDIDLFPGGMSERPLQGGLIGPTFGCIIALQFRQLRKCDRFWYENEDPAVRFTEAQLAELRKITLAKILCDNMDIQGEMQRAAFDLPSNFLNPRVPCNAHPAININAWKETARGQGCIIGDKQVSVGQSAFPSPCTSCICTSEGGNCASLRVTDCRQLLREWSKDDILRDEVCTAQCGFLLRESASTNLPQNLNPPPLRNVRNGRPQFRNADSFDSFGGFKLPDLTPFIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYW7</accession>
    <name>A0ABM5KYW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050515383.1">
        <property type="nucleotide sequence ID" value="XM_050659426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515384.1">
        <property type="nucleotide sequence ID" value="XM_050659427.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659426.1">
        <property type="protein sequence ID" value="XP_050515383.1"/>
        <property type="gene ID" value="LOC114341478"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659427.1">
        <property type="protein sequence ID" value="XP_050515384.1"/>
        <property type="gene ID" value="LOC114341478"/>
    </dbReference>
    <dbReference type="GeneID" id="114341478"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="19">
        <location>
            <begin position="99"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="18">
        <location>
            <begin position="321"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="17">
        <location>
            <begin position="615"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="895" mass="104092" checksum="C9CC7B303B345EAC" modified="2025-10-08" version="1">MSEDFRPLLGNLRQPSMRSFYQRIRILKPSTLRKCVFAVILFSVLLIIIYFRQTRSPYLTKFIQRSTRPEPNIRCGVMNGPRILQNHDHKSDARLRSYPKVLVFVETMYSQLGKSIAELLVHTRLKYKIEVSGKSVPVLTNLDKGRYGVIVFENFNKYLQMDNWNRELLDKYCREYSVGIIGFITPEEETYVGTQLKGFPLFIHTNLKLKDAALNAASQILRLTRAGETVWGELPGNDWTVFQANHSTYEPLEWATRSDHFQLNDSNDSKIPLPTVIQDHGLYDNIQRVIFGSGLKFWLHRLLFLDSLSYLSHGQLSLSLDRKFLVDIDDIFVGEIGTRIRPDDVMALVDTQERLANMVQGFKFNLGFSGKYFHHGNSEEDKGDDLILENVDKFMWFSHMWNHQQPHLYDNLTLLMEDMLLNKNFAKEKGIPVDSGYSVSPHHSGVYPVHEILYTAWKKVWNIRVTSTEEYPHLRPARLRRGFIHRNIMVLPRQTCGLFTHTMFIDRYPGGREKLDESIQGGELFQTIVYNPINIFMTHMSNYGNDRLGLYTFESVIKFIQCWTNIKLSSAPPLQLAESYFKLYPGEADPVWGNPCDDPRHQKIWSRNKSCDSLPKFLVIGPQKTGTTALYTFLSLHPAIASNLPSPTTFEEIQFFNAHNYLRGLDWYMDFFPTDANSSARYYFEKSATYFDGELVPRRVHALLPHAKLITILISPAKRAYSWYQHTKAHGDIIANNYSFHQVITASDTAPKPLRDLRNRCLNPGKYSQHLERWLTYYPSQSLHIIDGEELKNSPVEVMNELQKFLKIMPFFNYTEHLRFDPKKGFYCQVVTGDHTKCLGRSKGRQYPPMEEKSHKYLQRYYLSHNTALVKLFKKNGNRNIPNWLKEDLSDKSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L000</accession>
    <name>A0ABM5L000_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP157 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515764.1">
        <property type="nucleotide sequence ID" value="XM_050659807.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659807.1">
        <property type="protein sequence ID" value="XP_050515764.1"/>
        <property type="gene ID" value="LOC126890681"/>
    </dbReference>
    <dbReference type="GeneID" id="126890681"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038844">
        <property type="entry name" value="CFAP157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="28"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="653" mass="76073" checksum="984784FFF183FF73" modified="2025-10-08" version="1">MAKGKGKKGKKAKKPVEIDPNALTEVDKTFYELTITDLNRKLARLRSQNQELEQKNEELVQEKEKLDEDRNDIIMYLKRTLQEKTSEIAELEERITAMKQEQEDTTQMYEEKIVEMTNEYNTMHDQLTSENKLLEGKLNSLEEFRSQRDELMKKFETQENDMEAQEKRHKREMYEIERKFIIAKDRLKKDMEAKLRQLSTEFHDATELRIAATTHRVIRENIAVNNELDVLLNNQQKLFNENVKLKDKDSNLHRQVELLEAEKTKALAKVRVQVKLIDRLSDDNEFLISQRDHYKAYETKYLECCRKTKDLTEKLTCSEHDKRILEQNLHHVRCDRTAIQTDYLYLQEENERLNEIMIEAVSCIKEALIVRIDSDMSFKASKRDNLLNSLLTLLNKARDHKIRCPSLETVSLFEATYARGDLGFVPKPVELRSAVPVRRNMDTQTGASFEEYIATGYIAKTKMLYSEIEDEEDIVEQSEGELREEEGQHESVLYFDDQEIPGEESSDDGTNLYDLIPEEEPVRDEQTTDVEQVQSPKEDEPEERTSRTSGDQKFSEERTSRTSGDQKFPEGRTSRTSGEQKFPEGRTSRTSGDQKFPEGRTSSTSGDQKFPEGRTSRTSGDQKSRGKRTSRNSEDQKSPEEDLNTKSDSKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0D2</accession>
    <name>A0ABM5L0D2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial cardiolipin hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial phospholipase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase D family. MitoPLD/Zucchini subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515894.1">
        <property type="nucleotide sequence ID" value="XM_050659937.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659937.1">
        <property type="protein sequence ID" value="XP_050515894.1"/>
        <property type="gene ID" value="LOC126890761"/>
    </dbReference>
    <dbReference type="GeneID" id="126890761"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="8">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="213" mass="24878" checksum="7029CA3FB4F61EA8" modified="2025-10-08" version="1">MNKFLCIFISVSSITLPILLTYVVKRRYRRKIQLLLEKDNNCYYQLLAVDMRNFNCRQHLYDTKVECGEQCSLAYYRTIQNFISSAKSSICLCVLMLTLSSVVRQLVDAKKRGMTVRIIIDKVMLDTKVVKSNFTYMAQQGIPFKFQPLESSKMHHKFCLIDKDEGDGAKMFFGSLNLTSQGFCKNFDNTILTNNKEIISRFSEEFEELWELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2A4</accession>
    <name>A0ABM5L2A4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516574.1">
        <property type="nucleotide sequence ID" value="XM_050660617.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660617.1">
        <property type="protein sequence ID" value="XP_050516574.1"/>
        <property type="gene ID" value="LOC126891440"/>
    </dbReference>
    <dbReference type="GeneID" id="126891440"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="372" mass="42899" checksum="9B0122F94491FC7F" modified="2025-10-08" version="1">MPLMLIIMKEVIHFYNQSAKRNAVLTEHVGGQLVSLCETRWVDRHDAVILFFCALPEIVDSFTEISEWKESESAKKAVLYINSITSTEFIFSCVCLVDILKRTLPLSKLLQKPNLDLNKASNAVTDTLTCLKDRRRNCDDHFTELYLEALTTSEKLGVQLKMPRVVKSQRHRENYEAETGMEYYRMSMYIPLLDNVITDLQTRFSEENLLCFDLNLLMPANMLNTNVSEKCLELNVRLQKVCQNFKTLLASDSEVVLEGELSIWIAKWSREKEEGIKIPNCAIEVLKCCDGDMFPTVRTLLQILITLPVSVASVERSFSSLKLVKSWLRTRMVEERLNGLCLLYIHRDIELNVENVIERYAKGGKRRLDFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5C0</accession>
    <name>A0ABM5L5C0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517637.1">
        <property type="nucleotide sequence ID" value="XM_050661680.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661680.1">
        <property type="protein sequence ID" value="XP_050517637.1"/>
        <property type="gene ID" value="LOC126892196"/>
    </dbReference>
    <dbReference type="GeneID" id="126892196"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="186"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="655" mass="74814" checksum="D022407F1D3C2ED9" modified="2025-10-08" version="1">MFRKGLSEDELRRLAEESDFSDSSMSESTFYDSDADPVYNENVTDASSDSYSSEYESRRKKAKICKQTQNCKEFTAGSSSNQKEADTRRIEKAESANVSLEAVIDDVSRNKITAGPSCIQKEADTRRIEKAESANVSLEAVIDDVVSRNKITWSDVPNPDDLNKFELSFTSGINQEELAKLTDHKPIDFYLLFIDRQVQDLLVTETNKYAEQTIIAGIVNESITKHSLMSNWRPIDRKELLRFLALIIWMGLDRKPKLRNYWSNNLLYKNEVSKMCEISRSRFEILLHFFHISDNESCPPGNRLYKISPLVQILNEKFQKMCTPRESLCIDETMVPFRGRLSFLQYIPGKRHKYGVKLIKLCVADGYTYAVKVYGGKEMQPSEKSLASRVVMELMQPLLDTGRSLYTDNFYTSVDLAHDLNNRKTHLVGTLRSNRKHNPKAVVNAKLKRGDMKYLQSNTKVVIGKWKDKRDVLFLTTKDIPLMIDVQTKRGPVPKPSTIVDYNSAKSFIDVSDQKAAYNSPVRRSMKWYRKLAVELLTNTALVNSLVLYKSVTGKHLSITEFRKQIVQSLLMPQTTSENSLTTSENSLTTLHTLDEKEKRGRCSACYKNFSNREGRASAMKNAKRVYTFCPACAVNTAYMCVKCFVNIHTCSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8H5</accession>
    <name>A0ABM5L8H5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518741.1">
        <property type="nucleotide sequence ID" value="XM_050662784.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662784.1">
        <property type="protein sequence ID" value="XP_050518741.1"/>
        <property type="gene ID" value="LOC126892912"/>
    </dbReference>
    <dbReference type="GeneID" id="126892912"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="151" mass="17142" checksum="5F2E636E0F3FD724" modified="2025-10-08" version="1">MKFVLSSLAEQVVCISGYLQQGATKMEMMETLIGHSSYDVNYMGTHDEGKKINQNMKVATGRRSYKCEICFKQFTTASHLKRHLRVHTGDNPYKCSICFKQCTDRSYLQQGETKMEIMETLIGPSSYDGNYMGTHDEGKTINQNMKVATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA69</accession>
    <name>A0ABM5LA69_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neurofibromin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519332.1">
        <property type="nucleotide sequence ID" value="XM_050663375.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663375.1">
        <property type="protein sequence ID" value="XP_050519332.1"/>
        <property type="gene ID" value="LOC114335088"/>
    </dbReference>
    <dbReference type="GeneID" id="114335088"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13313">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05130">
        <property type="entry name" value="RasGAP_Neurofibromin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="1540"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="754"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2434"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2681"/>
            <end position="2733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2434"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2444"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2691"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2702"/>
            <end position="2714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2733" mass="309318" checksum="0D94C8E830E26362" modified="2025-10-08" version="1">MATQKPGEWANTLIVRFEEQLPCRIGPQTTHSSINEEQNKNCIIQISRYRFALVLDGFVKVLKRIHELYQTGTCSASKHGPELEKNYFDSLIIVLETLEKCFSIQPKDSITLTMEENNNLKCLLKEICTFLVAKDMPSDNPNVHAIKQLASKVLFALSVNFFNAVFNRISSKLQELASCPDENPDFSDIELIQYINVDVSRLSRLFVEAISKFRLLKKTAHLMLVTSLEKAIWNWMDTYPYEFAELQKNPNEDMAKCAEQLFDILDAFGDNKKGRSAVWSLQIMLLILAPKVLEEIVNADSGAPCSPRHSKKKMFIDNIKKCISPHGNSKQLTEAAAVTCVKLCKASTYIKVLDPNNVTFVLVQSILNDLKTLLFNPQKPFSRGQNYLYQDMDLMIDCFVSIFRIKPHNNEALKVCLSLTSPPTFHFVLVRSLYKIVTQPRLFWWPQIDIVYSKASELRAMFTDTLNKVSQGYIAHTPLRMIQITLKGKDCPGKFKDRAEEVHLLLYMVRLVHADPMLMLNNQGKAGHEIQSSTLELINGLVSLVHQPTMPEVAQEAMEALLVLHHPEKIEVWNPEAPINTFWDVSSQVMFSISQKLIQHQIMNYTDILKWLREVLICRNAFLAKHKDYANLGSSIAICKQAHIKLEVVFFMYLWSTDMDAVLVSMSCFALLCQEAEIRCGSDEVTVTYLVPNYHVYQELAQASTVLITGRAALQKRIMALLRKIEHCVNGVQPAWEETFMNWNGMCKNLSSKARSEEGQMEPFHRSVGKRRASHQNSEHELEDQINEWANMTGFLCALGGVCLQRKSPCRPPLSTSSHSGLSSMSSIGSSNLGSEPISGTRKSNTLQSQQTPQDQRQYCPVTSFVDLLLRLLVCSNEKFGAQIQKHVKELIGHEMSSALYPILFEQTKSIVDKFFDQQGQVVVNEVNTQFIEHIVFIMKNILDCTKNDQPSEHLGVTSIEGMMLAVVRYVRHLDMTVHAIHMKTKLCQLVETMMNRRDDLAFRQEMKFRNKLVEYLSDWIMGNSHQIAPPGSGDVTTITRELDQACMEAVAALLRGLPLQPEESDRGDLMEAKSQLFLKYFTLFINLLGDCTEPQEVDKDLGKQKVFSGKHNTLRNATIQAMSNLLSANIDSGLMHSIYLGYNKDLQTRAAFMEVLTKILQQGTEFDTLAETVLADRFEQLVQLVTMISDKGELPIAVALANVVTTSQMDELARVFVTLFDAKHLLAPLLWNMFYREVEVSDCMQTLFRGNSLGSKIMAFCFKIYGASYLQSLLEPFIGPLLDDPCCSFEVDPARLEPNEDIEENRQNLIALTQRVFNAIVNSIDKFPPQLRSMCHCLYQVLSKRFPLVPQNNIGAVGTVIFLRFINPAIVSPQEMGIVCKQVPNSVKRGLMLMSKILQNIANHVEFSKEQHMLPFNDFLRAHFEIGRRFFVQIALDCETVDQTSHSMSFISDANVLALHRLLWNHQEKIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHKPVDSHMLFSSYARWSSIDMSSNNFEELMVKHNMHEKEEFKSIKSLNIFYQAGTSKFGHPVFYYIARRFKFGETNGDLLIYHVILTLKPFCHAPFELVVDFTHTCTDNRFRTEFLQKWFYVLPEVAYLNLAAAYIYNCNNWVREYTKFHDRILVPLKGNRKIIFIDVPNKLNDYIDSEQQKLPGATLSLDEDLKVFHNALKLSHKDTKVAIKVGPTAIQITSAEKAKVLSHSVLLNDVYYASEIEEVCLVDDNQFTLTIANDSSPLSFIHNDCDSIVQAIIHIRNRWELSQPDSVTVHQKIRPKDVPGTLLNMALLNLGSSDPNLRTAAYNQLCALTATFDLKIEGQLLETQGLCIPSNNTIFIKSVSEKLATNEPHLTLEFLEECIQGFRVSSIELKHLCLEYMTPWLPNLVRFCKASEENKRQKQVAGIIEKLILLTIEETQMYPSIQAKIWGSIGHVPELIDMVLDNFIHRSVNSGLGSPMVEIMADTAVALASANVPLVAKKIIGRLCRVIKKVVDKTCQSPTPLLEQHMMWDDIAILARYLLMLSFNNSLDVVRHLPYLFHTVTFLVCSGSLSMRASTHGLVINIIHSLCTCTKPSFSEETQRLLRLSLDEFSLPKFYLLFGISKVKSAAVTAFRSSYRHPNEKWLGNERSFSGTGNQDRERLSLTSLEVITDALLEIMEACMRDIPDCDWLTSWTSLAKSFAFCFNPALQPRALIVFGCISKSITDKDMKQLLKILVTALESFNDIILIEALVMCLTRLQPLLRPESPIHKALFWVAISVLQLDESSLYASGLALLEQNLHTLDSQGIFEDKTLENVMMSTREPLEWHFKQLDNAVGLSFKANFHFALVGHLLKGYRHPTPTTVSRTVRILTMLLTIVAKPQKRDKFEVTPDSVAYLTALVGFSEEVKSRCHIKHSLPRQMTDSISQDNFSVDSGQSSGIQKGSSTESSMSNSINRRQKSWDLLDQTAIAQARHKQPTSSTGQHQIRSTRVSVSNENNVLLDPEVLTDFSTQALVLTTLATLVKYSTDEAETRTLYQYLAEGAVVFPKVFPVIYNLIDMKITNVLTSCHDQEILSAVRSIIQNMIACEDTEQQQLHYLQSCGFGGLWRFAGPFNKFFQYNNMAESSELFVNCLEAMVVTCLPVDEIEAENGEMTQYPSMLSVSSNTNLSSSLSSLTLGSPTEKDMTRDVEGGSTTSLGRSSFNKQRGIKSKSLIHSEYSSKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EY59</accession>
    <name>A0A6P7EY59_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamic acid-rich protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114324466</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128134.1">
        <property type="nucleotide sequence ID" value="XM_028272333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EY59"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272333.2">
        <property type="protein sequence ID" value="XP_028128134.1"/>
        <property type="gene ID" value="LOC114324466"/>
    </dbReference>
    <dbReference type="GeneID" id="114324466"/>
    <dbReference type="KEGG" id="dvv:114324466"/>
    <dbReference type="InParanoid" id="A0A6P7EY59"/>
    <dbReference type="OrthoDB" id="6288648at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028128134.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51113" checksum="BEDDB1C307D08479" modified="2020-12-02" version="1">MTTSRVIRGTRAKVFLYLCGILIIVGIIACYNNTLSHLDDVKKSNFICHQQEENLSTQLQVISDYKQRLEKTLKTEQADHVQTKANLENQLKEERSKYENEATDMKHKLESVQQHLNLLQTQYDDYKEETDKGQKQQQEEINNLEARISELLEEEKKLRSSRESLKTQYTELQSEKEKLAKELENQNKNSNDQELSKLNKENKELKDEVEHLKAKCNNQETLVEPNVQQVEDTNKNLETHDSNKDEKIAHQEPDTGAGNAPLFVLAQPYANDNKVVSSSTSSNNVLKPSQASLDGARPILVPTLTPVSVRKDNKVPEGVVAIPEKKEDEVVNARYQNARESANELVPQAEKAAKDEIEKENVAHEVFDAPLFHDGLQFDNDNFKQVDKPNFDKRHIDTLGAPKDKKNQEDQGDYKDQNDVQLEENDDDDGDGYDDHLARQKEPAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4P2</accession>
    <name>A0A6P7F4P2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114325043</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128768.1">
        <property type="nucleotide sequence ID" value="XM_028272967.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518867.1">
        <property type="nucleotide sequence ID" value="XM_050662910.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518868.1">
        <property type="nucleotide sequence ID" value="XM_050662911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4P2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050662910.1">
        <property type="protein sequence ID" value="XP_050518867.1"/>
        <property type="gene ID" value="LOC114325043"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662911.1">
        <property type="protein sequence ID" value="XP_050518868.1"/>
        <property type="gene ID" value="LOC114325043"/>
    </dbReference>
    <dbReference type="GeneID" id="114325043"/>
    <dbReference type="KEGG" id="dvv:114325043"/>
    <dbReference type="OrthoDB" id="440745at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF7">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028128768.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="50573" checksum="4F796620ED9566E0" modified="2020-12-02" version="1">MSVVTFEKPMQHVSLADWYAKQWQMQQTNDTRRNDSFCMRHELRQLRNETRIRTEWDTYHNNVRLADRITEVDRWRDVLISCLDRVNHEIKLLKDEKFDTERELDALGIPLGIISECISMRDCRQGTELTYDEGDTELKKELCLVENVKRMLVERCQSAWEKLNKLEEVKFYLNLDINDKSEAYEIDKDQLTLDKNCANITFKIDPLRVVKGSVPYETWLEHTRNTKQLADNELADTLKLRESLFVVRERARNDMLAQRDRVDFILRKRIYDIQRVRNEIEWQQLKMREEMEKVLKEIRDLEAALLAKTDALKLAETRLENRSYRPGVELCRDEPEKGLKEEVLQLRQTRKDLQDKIDCAKATYNALEDQQVRIDKDLDDKGQGLMTDIRCLDMRIRLRTGEFAGPATSTDRNIQLTRMEKEIPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F505</accession>
    <name>A0A6P7F505_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114326003</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114326003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129967.1">
        <property type="nucleotide sequence ID" value="XM_028274166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F505"/>
    <dbReference type="FunCoup" id="A0A6P7F505">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274166.2">
        <property type="protein sequence ID" value="XP_028129967.1"/>
        <property type="gene ID" value="LOC114326003"/>
    </dbReference>
    <dbReference type="GeneID" id="114326003"/>
    <dbReference type="KEGG" id="dvv:114326003"/>
    <dbReference type="InParanoid" id="A0A6P7F505"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129967.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20535" checksum="BF60E56FEB2E9EAB" modified="2020-12-02" version="1">MRSAQNLIKMSLRNVEIKAKVHDLDDIVNRAKSLNPIKSEIIQQHDTFYNVSHGRLKLRQFKDSTGELIYYDRPDSEGPKISNYRKSAITKESLNDLPHVLEEALGVKQVVKKVRQLFVVGQTRIHIDNVEALGNFMELEVCLEDNQSLEEGKQIADDLMAKLNVKKEDLLSGAYADMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F870</accession>
    <name>A0A6P7F870_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small integral membrane protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325724</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129655.1">
        <property type="nucleotide sequence ID" value="XM_028273854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F870"/>
    <dbReference type="FunCoup" id="A0A6P7F870">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642077.1">
        <property type="protein sequence ID" value="XP_050498034.1"/>
        <property type="gene ID" value="LOC126879124"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7F870"/>
    <dbReference type="OrthoDB" id="8755372at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MITRAC7/Phoenixin"/>
    </dbReference>
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        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34923:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15061">
        <property type="entry name" value="MITRAC7_Phoenixin"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129655.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="8397" checksum="D5069AA254A52454" modified="2020-12-02" version="1">MAPRLVGWRYAALITGLVGMIGLAIYPIIIDPMMDPSKYKRMQERSRTGIRQEDIQPGNMKVWTDPFDRNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8T6</accession>
    <name>A0A6P7F8T6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PI-PLC X domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114325918</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129870.1">
        <property type="nucleotide sequence ID" value="XM_028274069.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A6P7F8T6">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274069.2">
        <property type="protein sequence ID" value="XP_028129870.1"/>
        <property type="gene ID" value="LOC114325918"/>
    </dbReference>
    <dbReference type="GeneID" id="114325918"/>
    <dbReference type="KEGG" id="dvv:114325918"/>
    <dbReference type="InParanoid" id="A0A6P7F8T6"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08616">
        <property type="entry name" value="PI-PLCXD1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042158">
        <property type="entry name" value="PLCXD1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="29"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028129870.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38367" checksum="B5CFA4BA0082AA13" modified="2020-12-02" version="1">MNNVVSCYQEDSVPDLSEDLENWMSRLPHELRQTPIIYLAIPGSHDSFTSAIRSDSELAPDAEDAIKKLSFLGPVLKAFMVKWARTQTYMAKDQLIRGIRYFDLRIGTRQGTQDLYIVHGLYSVTVQTCLDEISSFLDTHTQEVVILDFQHFYGFTQSDHDRLMQMVNKTFGAKLLPFTQHMNYVSLEYMTTQYRYQVICVYRSDASRFGQPLLWPSRTFPNPWPNTVSKRYLFEYLHHGLKNRPADTAYVTQCILTPPGWFIFKHLYCSLKKTCGIKLEEPRSTWIENQTPGANGLNIIIADFIELTDCRYVKEVINLNQKLLLNNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB04</accession>
    <name>A0A6P7FB04_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114326459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326459</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130640.1">
        <property type="nucleotide sequence ID" value="XM_028274839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB04"/>
    <dbReference type="FunCoup" id="A0A6P7FB04">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274839.2">
        <property type="protein sequence ID" value="XP_028130640.1"/>
        <property type="gene ID" value="LOC114326459"/>
    </dbReference>
    <dbReference type="GeneID" id="114326459"/>
    <dbReference type="KEGG" id="dvv:114326459"/>
    <dbReference type="CTD" id="39897"/>
    <dbReference type="InParanoid" id="A0A6P7FB04"/>
    <dbReference type="OrthoDB" id="8196648at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027932895" evidence="3">
        <location>
            <begin position="23"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028130640.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="69317" checksum="0605E91E3D22FF7F" modified="2020-12-02" version="1">MYFEKISIFFILVVLITNETSAGDDDYNVLHTDGAYEFGYNNPDSYHYAQANRNNVVKGEFGGRNPKTGAIDSTIYTAGPRGFRPRGKNVVRKYDLSQAGPRPVGSRYDPYFDPYEDPSYSFSFRTRTYNRDENANRLGDVTGRYSYTDDVGERHNVEYIAGKNTGFHVKTPFPDSNPKAYGPLYFRGRGRPIPRGRTSIQRGLDGSYKFVSAGPDQRRTETSDATGHVRGSYTYLDDKGVQHSVHYIAGPETGYRVLKTVKGPHLPTVFPFNRPDIIPPDFYDYNDKDVFDTAASGHIKPGRPGSRPGGRPPSSKDSGQAEQDNGGKDGDSDFGQPGFADSGNDFEFGRKKPSGNKPSTAGGGKPSKSPYDEDGSDGYDTDDDFGDLFGDGGGKKQGPGKGGSSKSKPTSTTNKPFLPSDGSFGNGISKEDSSGSKEDGGSKPSNEYIPPNNGKSGEGSDENYGSKGDSFGKPSSRPSSTRPSGSFRPSSRPQSTFSTEGDDFGLFGSETNRPKPPPYQGDTGSTGPVITIGAPNKNCPRCQGAVLTNVGDTYLSVPPGVSVRAHVQAIDLLPYSSRFPGPSEQYKSELPLNTEQLNSENDKIVGEVDITTESDSEEFTTEETTTDVDVTTNLPNTDAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FB19</accession>
    <name>A0A6P7FB19_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114326466</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_028130655.1">
        <property type="nucleotide sequence ID" value="XM_028274854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FB19"/>
    <dbReference type="FunCoup" id="A0A6P7FB19">
        <property type="interactions" value="1100"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274854.2">
        <property type="protein sequence ID" value="XP_028130655.1"/>
        <property type="gene ID" value="LOC114326466"/>
    </dbReference>
    <dbReference type="GeneID" id="114326466"/>
    <dbReference type="KEGG" id="dvv:114326466"/>
    <dbReference type="InParanoid" id="A0A6P7FB19"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000001">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028130655.1"/>
        </source>
    </evidence>
    <sequence length="633" mass="72628" checksum="80C5C257DB84BB50" modified="2020-12-02" version="1">MGLLTEGSPLSWEETKKHAQHVREHGITQFINLYKKLRDREGDILKWGDEVEYIIVKFFDDKKEAKVSLRSHELLTILNQKEQDDPNGVKSLWRPEFGAYMIEGTPGHPYGGLLAHFNIVEANMKHRRQEVMELLQPNETIMSITSFPRLGCENFTDPSTKATPDKGATRSLFFPDEAIYPGHPRFENLVRNIRMRRGEKVAINLPIYKDINTKIPVDDSSKHSNAALEDHVYLDAMGFGMGCCCLQLTFQACNITEARTLYDQLTPLCPIMLAFTAASPLHRGFITDIDCRWNIIAGSVDCRTEEERGLKPLKENKFVIKKSRYDSIDSYLSPQGEKYNDIPLLYNEEDYKKLIDNGIDPLLAGHIAHLFIRDTVSLFSEKVHQNDEEDSDHFENIQSTNWQTMRFKPPPPQSTIGWRVEFRPCEAQITDFENAAIVCFVVLLTRVILSYQLNFLIPISKVDENMQNAQKRNAARDQKFWFRRDITTHVSPPAANECCKGTTKDCDMFVQMTINEIINGKGEEFPGLIPLINNYLSGMDVDADTHCTIQQYLKFIQRRASGEILTTASWIRKFVTEHPEYRYDSVVSERINYDLLKTIEEIQSGKKYCPLLLGTSTMSKTKENIPTALRNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FBV4</accession>
    <name>A0A6P7FBV4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat-containing protein 47-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114328687</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133414.1">
        <property type="nucleotide sequence ID" value="XM_028277613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FBV4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647294.1">
        <property type="protein sequence ID" value="XP_050503251.1"/>
        <property type="gene ID" value="LOC126882384"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FBV4"/>
    <dbReference type="OrthoDB" id="67933at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="4">
        <location>
            <begin position="295"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028133414.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57803" checksum="612148E0BF806058" modified="2020-12-02" version="1">MWPEIEQAKIENRHELVLSGKEIASKIAKNGLDLSVFTLEGLNFLNISGTELSAIPDDIGKLANLQTLVLHSNKLEHANENIAKLTKLKMLDLSRNLITSIPDGFADLPLTTLNLNVNRLESFPEFTKNSKLAVLDLSNNKLKLFPRVCSEELVNLSELKLHGNEIEEIPNNIHVLPLLKLLDISENKIKTLPGELAECHKLKDLNLKSNPVSDRRLLKLIDQCRTKQVLDYVKQNCPKTTNGDVASKGKSKKKNKSKNDDEEDDNSVADYKYSINVKSHNNNFKVIIKNGVKTVREHFAACVVNNVSFTEESFKKFIQLQNKLHDSVCEKRNVATIATHDFNKLPPGDLIYSTSQPSELMIKPLNRATVMSGAELFTKLQTEANNLRKEKKRSTYSGIHKFLYLIEGKPQYPCVINANKEVISFPPITNSDISKIEVTTTRMFIEVTSSLSPHSCKNVLNTLLKDMVLLFEKDLEVEQVKTVDEQEQLKVVYPSKTDLVFEKSVSIKTNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEW6</accession>
    <name>A0A6P7FEW6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114328667</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Krueppel is a gap class segmentation protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133387.1">
        <property type="nucleotide sequence ID" value="XM_028277586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEW6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277586.2">
        <property type="protein sequence ID" value="XP_028133387.1"/>
        <property type="gene ID" value="LOC114328667"/>
    </dbReference>
    <dbReference type="GeneID" id="114328667"/>
    <dbReference type="KEGG" id="dvv:114328667"/>
    <dbReference type="InParanoid" id="A0A6P7FEW6"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0302">Gap protein</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="17">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028133387.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52996" checksum="953C89A5D521D7D8" modified="2020-12-02" version="1">MENLNVTIQDFMQICRSCLSRNNLSPINQNSINIFDKIADVKIDLDDDLPKQLCNECVTKTITISSFIQIVKSNDVYIRQVYESSKKIKLHPQIDDHESDISCDADQDIFSKDEISVNDSILKSENGESERETLNDIGIKHESTKMFKCNNCDKTFAKKHNLNQHLKAHSKLTVYDCKICLKRFQRISSLRRHDKIVHKGIKPFKCEICNKEFATPLRKQEHLRIHTGERPYVCNICGFTFKKYSTYYAHDIRHKIKRGEIPKSTKIPKKYPTKPPKNKKDLECEFCQKSFSSKQAVSVHKQIHFGEKCFLCTECGKSFMRKNHLEVHVRIHTGEKPYQCNDCGKDFRQPGAYKNHLLIHNNKRPHKCDVCEKSFVQIGHLQSHIKIHTGEKPYECTLCGKAFAQSGNLRAHTRIHTNERPFRCEICCLGFFDSSSLKKHKRTHDRIEVKNEDPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHD9</accession>
    <name>A0A6P7FHD9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich protein DOT1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329437</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134342.1">
        <property type="nucleotide sequence ID" value="XM_028278541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHD9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278541.2">
        <property type="protein sequence ID" value="XP_028134342.1"/>
        <property type="gene ID" value="LOC114329437"/>
    </dbReference>
    <dbReference type="GeneID" id="114329437"/>
    <dbReference type="KEGG" id="dvv:114329437"/>
    <dbReference type="InParanoid" id="A0A6P7FHD9"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027955603" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028134342.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="8977" checksum="41EFA21B2B6E35DD" modified="2020-12-02" version="1">MRGFVAVVVSLLAFILLVSQCTALPNPWGNYNRGGGRGYGGGAGYGYGGGYGGGGGGGGGGGGGGGGGYGGGYGGGYGGGYGAGYGGGRGHGRHGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHL6</accession>
    <name>A0A6P7FHL6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM45A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114330252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135376.1">
        <property type="nucleotide sequence ID" value="XM_028279575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHL6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279575.2">
        <property type="protein sequence ID" value="XP_028135376.1"/>
        <property type="gene ID" value="LOC114330252"/>
    </dbReference>
    <dbReference type="GeneID" id="114330252"/>
    <dbReference type="KEGG" id="dvv:114330252"/>
    <dbReference type="InParanoid" id="A0A6P7FHL6"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042431">
        <property type="entry name" value="FAM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544:SF1">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544">
        <property type="entry name" value="PROTEIN FAM45A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135376.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37313" checksum="F66E4BA878A9D77B" modified="2020-12-02" version="1">MFFKPTSFHVLEKENTENLITWNYPSISDELKTVLIKTCFSHGVEACGLFYFKRLGKQWIHIKQFIVNNDKAAAVIVVSQCFQPKLYETLCDLFAAQYSRSGSGADLVKLYLQIYTKNGIYDNDDFISLNNFTWKTNLKGLIKSLGLETILIYNALLLKKQILVYHSSVEDLQEGLASITKLVLIRKPEDLLLPLANSLSEIKEVSTYSLIGTINKNLLHQRNIFDVFIDLESQSITLTDKARDDFQMSSLHKEIAHFLVQLSESDGSEQDLITAVARKTSDLFKYLKSFCDDKEEGIKVTSIESKLSNKKLAIFLINLAMTENILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPQ5</accession>
    <name>A0A6P7FPQ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114332665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114332665</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138294.1">
        <property type="nucleotide sequence ID" value="XM_028282493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656062.1">
        <property type="protein sequence ID" value="XP_050512019.1"/>
        <property type="gene ID" value="LOC126888052"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FPQ5"/>
    <dbReference type="OrthoDB" id="7450257at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028138294.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37318" checksum="98DE4734AA36C319" modified="2020-12-02" version="1">MLDSEEIAVSHVCVMTMIDGKVCNAITETASSQTCYICKATPKQMNDIEKLLKREVVQENLKFGLSTLHAWIRFFECLLHISYRLEVKVWQIRGSNNRAVFENKKRTIQQIFRDRTGLLVDIPKSGGSGTTNDGNTARRFFADPSLSSEITGIDKDVIMRFGIILRTLSCGYAIDVRAFEEYCLETAKLYVAKYSWYYMPSSVHKILLHGAIVIKEAILPIGQLSEEAQESRNKDLKSFREKHTRKISRISGNQDLLNRLLITSDPVISSLRQYPLRKSSNISSEVVSLLKAPSLESMEADSLRALQLNMESRQVSSSDEEDDSASDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FU49</accession>
    <name>A0A6P7FU49_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-galactose dehydrogenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114334046</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139846.1">
        <property type="nucleotide sequence ID" value="XM_028284045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FU49"/>
    <dbReference type="FunCoup" id="A0A6P7FU49">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284045.2">
        <property type="protein sequence ID" value="XP_028139846.1"/>
        <property type="gene ID" value="LOC114334046"/>
    </dbReference>
    <dbReference type="GeneID" id="114334046"/>
    <dbReference type="KEGG" id="dvv:114334046"/>
    <dbReference type="InParanoid" id="A0A6P7FU49"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010349">
        <property type="term" value="F:L-galactose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19163">
        <property type="entry name" value="AKR_galDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000011">
        <property type="entry name" value="Aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044479">
        <property type="entry name" value="LGALDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028139846.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40130" checksum="9608BC6BB984D774" modified="2020-12-02" version="1">MALPETFVPGFHDEAAVRKMQYTKLGNTDMHVSKLSLGTGGFSYFYGDYDIEECKKTVHEAIKRGINYIDTGPWYGHGTSETILGKCLEGIPRKAYYLATKIGRYEQDPKLMFNFSAQKTRESINTSLKRLKVDYVDVLQVHDVEFSPSMDTILNETLPTLEELKKEGKTRYIGITGYPVSTLVEVIEKSKISINMILSYCRLTMIDDTLRSFIPTLQSKHVGIVNAAANSMGLLSNFGPQNWHPASEHIKDICTEARNLCKENDVELGKLAIYYSLQEKGTETIMVGMNTPKLVDINLEVVYNGLTPKEQEIYQQVLKIFEKLTERHWENVELQNYWKIMKGEGSAGFFTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUY1</accession>
    <name>A0A6P7FUY1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesol dehydrogenase-like isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114332985</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138592.1">
        <property type="nucleotide sequence ID" value="XM_028282791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUY1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028282791.2">
        <property type="protein sequence ID" value="XP_028138592.1"/>
        <property type="gene ID" value="LOC114332985"/>
    </dbReference>
    <dbReference type="GeneID" id="114332985"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028138592.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27200" checksum="4E21579DECDAC223" modified="2020-12-02" version="1">MVLSMDRWVGKVAIVTGASSGIGTAVAELLVEKGLLVVGAARRKENVDALAQKLQGKKGKLYSVKADVAKEEDIKELFKWTSANVGPVSILINNAGCHHKTGLIGGDTAAWRATIDVNLIAVCIATREAIDIMQRNNIDGYIIHINSLFGHTVLNIPDVDVYPATKHGVTALTETLRHELNARKSKIRVTSISPGIVDTEIISNIKKSNAFALIKDAMLKSEDIADAVSYVLSTPQHVQVHEIIIKPQGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FV17</accession>
    <name>A0A6P7FV17_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Lactosylceramide 4-alpha-galactosyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC114334359</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140196.1">
        <property type="nucleotide sequence ID" value="XM_028284395.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140197.1">
        <property type="nucleotide sequence ID" value="XM_028284396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028140198.1">
        <property type="nucleotide sequence ID" value="XM_028284397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FV17"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284395.2">
        <property type="protein sequence ID" value="XP_028140196.1"/>
        <property type="gene ID" value="LOC114334359"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284396.2">
        <property type="protein sequence ID" value="XP_028140197.1"/>
        <property type="gene ID" value="LOC114334359"/>
    </dbReference>
    <dbReference type="GeneID" id="114334359"/>
    <dbReference type="KEGG" id="dvv:114334359"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035248">
        <property type="term" value="F:alpha-1,4-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="7">
        <location>
            <begin position="215"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028140196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028140197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028140198.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40545" checksum="73173C6E657D8CC0" modified="2020-12-02" version="1">MFIKRWTKYWRYFAVAALIVILLKLMSQPRDNISCYRRKDMESLPDISTVEPRKGKSIFFHETSCNSAAKEKILITAREGCAVESAAKANPNFDVYLLYTSPGVFRFEGDESDEILKALMSYKNVKIMHLDYEKYTNGTPVEELYKSGRLEGSKFVVSHASDVLRYLTLWKYGGIYLDLDVIVIKSLEDLKPNYAGLQSRFDVAAGVVSFDADSIGHLMAGKCLNDLKRNFNGNNWGNNGPGVITRLLIDLCNIKNHRKKMDIASKMLNKHCGGFTVFEPEVFYPVRYEDWDFYFDESKLNYIISHTNKAYAIHMWNNLSKKTKLRLDSKAPYLYYAKKHCPRVISALKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW08</accession>
    <name>A0A6P7FW08_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GILT-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114331672</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137093.1">
        <property type="nucleotide sequence ID" value="XM_028281292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW08"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281292.2">
        <property type="protein sequence ID" value="XP_028137093.1"/>
        <property type="gene ID" value="LOC114331672"/>
    </dbReference>
    <dbReference type="GeneID" id="114331672"/>
    <dbReference type="KEGG" id="dvv:114331672"/>
    <dbReference type="InParanoid" id="A0A6P7FW08"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027977426" evidence="6">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028137093.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25104" checksum="B185027D1BF3C548" modified="2020-12-02" version="1">MESVTVLFVALCFAGISVQAADLKVSVYYESLCPDSIKFIKDQFNPAYSTVLKDKINVDFVPFGKATAIKSNGTWSFTCQHKEPECYGNKVQSCAIDIASYNTSIEFVVCAMKSGDASDDELLKQCAEDNQIKWDDIDNCLKSGKGDELLAKYGDRTNAVTPKITFIPTIVFNDVYTDKLQELALKDFLTVSEVLLEKPDCSKCSSSRMALSIAVLLLPLISMLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYY0</accession>
    <name>A0A6P7FYY0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Villin-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114332197</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137740.1">
        <property type="nucleotide sequence ID" value="XM_028281939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509264.1">
        <property type="nucleotide sequence ID" value="XM_050653307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYY0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653307.1">
        <property type="protein sequence ID" value="XP_050509264.1"/>
        <property type="gene ID" value="LOC114332197"/>
    </dbReference>
    <dbReference type="GeneID" id="114332197"/>
    <dbReference type="KEGG" id="dvv:114332197"/>
    <dbReference type="CTD" id="35058"/>
    <dbReference type="InParanoid" id="A0A6P7FYY0"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF137">
        <property type="entry name" value="VILLIN-LIKE PROTEIN QUAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="5">
        <location>
            <begin position="771"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028137740.1"/>
        </source>
    </evidence>
    <sequence length="836" mass="96500" checksum="ADFAAB8DFCE16F67" modified="2020-12-02" version="1">MQVLELQHDDYDDSSVYDIGSIDTAFRKINKNSTNFLIWKVENMNIIAIPKDQYGTFYTSDSYVIYAASLYGQSCGVDMVSKETKGSIEHHVHFWLGSQTNPDRSGVAAYKTVEVDNYLNGHAVQHRETEGYESARFLSYFKNGIRILKPEIINDCQPVKLYRVRGKRIPVVKEMPSVSWEHFNSQDIFVIKTPKIIFVWSGRAADAVEKLHATTIVEDMKEKHKIANLAFVDDGYEKTLQDDIKKEFNKYLPLEKRVVLPEVSENDENGNYQKSSMRLYKCADINGKYRVAEVKTGPFVQQDLHYEDVYILDQEVDGIWVWVGRKVSEKERSEALRNARGFVKKKKYPANTKVTRVVDSYEPQEFKMLFASWKSDNRILKPSILVSRYDAVTMEDRPSLAAETQLIDDGTGSLTIWRINQSRIVEIPKERHGNFFSGDCYIILYTYQTAVDQKHLLYCWLGSHATQEEINSTTLKVMEIDEELGQIGFHARIIQGRETAHFLQLFKGKLTIFKGRGVEFDDTGRNLKIPSQYLLHVYGSTSYSTKAVQVSVKASSFNSNYCFVLKRSKKAYIWSGTYSTGDQREMAKGFAGKDFELILEGKEREDFFSLLGGKTPYSTQIVKHENDPKPARLFKCSSSKGRFKAEEILFFSQKDLVPEHVMLLDTADSIYMWIGKLSNKEEKRLSAQKAIDYLQSDPAGRDMNIAIIHIKQEKEPPTFTGFFQTWDKSFWKTYKTFLKIRQEIESKTCCHNGNGTTNGYSNHSDSGDSEFDQYEKYPVNILKEPNEKLPPRIDPLNKELHLTHDDFVSMFKMAYTDFEKLPRWKQQELKKKVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0F8</accession>
    <name>A0A6P7G0F8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol-glycan biosynthesis class F protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114336167</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142296.1">
        <property type="nucleotide sequence ID" value="XM_028286495.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512033.1">
        <property type="nucleotide sequence ID" value="XM_050656076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0F8"/>
    <dbReference type="FunCoup" id="A0A6P7G0F8">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656076.1">
        <property type="protein sequence ID" value="XP_050512033.1"/>
        <property type="gene ID" value="LOC114336167"/>
    </dbReference>
    <dbReference type="GeneID" id="114336167"/>
    <dbReference type="KEGG" id="dvv:114336167"/>
    <dbReference type="CTD" id="40139"/>
    <dbReference type="InParanoid" id="A0A6P7G0F8"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142296.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24964" checksum="276A54FD470C906C" modified="2020-12-02" version="1">MDVSQDTHRLLICNNILTCLYLPVITLALNFSGNLYNIGKKVTYVEYALALAEILKYLRFYFVHKSVKRKLSIGNIIKSIITCALMLVIFYVGAILFGAPFLSEHYETLFFATLMTVLTTIPICLHLDHDNVYNLFSSLLDFDGNKLQEHFLINIRFTVFGAWLGAVLIPLDWNRPYQDWPIPCCYGAVAGCFVGNLYTVVQYYNYGYTYKKKGKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3G1</accession>
    <name>A0A6P7G3G1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15 16" type="primary">LOC114333439</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139109.1">
        <property type="nucleotide sequence ID" value="XM_028283308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028139110.1">
        <property type="nucleotide sequence ID" value="XM_028283309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028139111.1">
        <property type="nucleotide sequence ID" value="XM_028283310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3G1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283308.2">
        <property type="protein sequence ID" value="XP_028139109.1"/>
        <property type="gene ID" value="LOC114333439"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283309.2">
        <property type="protein sequence ID" value="XP_028139110.1"/>
        <property type="gene ID" value="LOC114333439"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283310.2">
        <property type="protein sequence ID" value="XP_028139111.1"/>
        <property type="gene ID" value="LOC114333439"/>
    </dbReference>
    <dbReference type="GeneID" id="114333439"/>
    <dbReference type="KEGG" id="dvv:114333439"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="130"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="226"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028139109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028139110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028139111.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34498" checksum="A4CE1F0A6BA27F08" modified="2020-12-02" version="1">MSPSPPTPFTYPFKRPWLKDYGAAAPVGGGSIGLKGIIAGGITGGIEICITFPTEYVKTQLQLDEKGDKKKYNGIADCVKKTVKSHGFFGLYRGLSVLLYGSIPKSAVRFGAFESFKNKMQRPDGTLSISGRLLCGMGAGVCEAILAVTPMETVKVKFINDQRSQTPRFKGFLHGVKMIVREEGIGGVYKGVTATIIKQGSNQAIRFFVMETLKDAYKGGDRDKKIPKIVVGAMGAFAGACSVYGNNPIDVVKTRMQGLEAKKYKNTLDCAVQIMKNEGPLAFYKGTVPRLGRVCLDVAITFMIYDSFMELFNKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4R0</accession>
    <name>A0A6P7G4R0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">B-cell lymphoma 6 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114335915</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142002.1">
        <property type="nucleotide sequence ID" value="XM_028286201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4R0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286201.2">
        <property type="protein sequence ID" value="XP_028142002.1"/>
        <property type="gene ID" value="LOC114335915"/>
    </dbReference>
    <dbReference type="GeneID" id="114335915"/>
    <dbReference type="KEGG" id="dvv:114335915"/>
    <dbReference type="InParanoid" id="A0A6P7G4R0"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF106">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028142002.1"/>
        </source>
    </evidence>
    <sequence length="941" mass="106266" checksum="DCC4DBF5D94B1432" modified="2020-12-02" version="1">MASSSGVQQQFMQQMNSPFHCKECGISLNSAESLEVHLQYHKENLLKNWAVQAQSSHSEETNNNTKTNIKRELISNNTIAAADSSDSMQKKSPDYSRATPETIFGHPPTPQSYQSASSPYQNQDNSTFSTNFQSYPVKLERSSPTPQYQNNYSNYPEQQYFSMDSSSQGQQFNQESFVHKSAYRYHPYNQNQSQNSPYDRQAQVSSSSPAYPPQPTPSPSPKQCDKCGYVCESASQLIEHLNMAHPSTPASHLVPYQSNQHFMFDHTVIKQEDPAQSEILDLDSHKVVHNVYPDEEKRQNGDPNPHSVSAMLNSWPSPQQTPQQKIFQQQEQRMFPNSESKMFSQNIPDNIPENKIFQSEQKLFQPHQMHSQEFLGNNVTTTSQESVSNGINQPPQAYRPFEHMTSPPNTAVISSTQVPTNPVPPPAPMGKGANWKSNEARRPKTYNCTACNKWFTSSGHLKRHYNTTLHKNAVKSSGQPDPASLPISAHHHPAREPSSKQDERPQSSSSGDEIRNEDNNSMPQYERLGPMSGMSGPYDRQPPPSVHHTPPLHSPMPHSPIPHSPMPQHPSPLGNHLGNPNLSNGSPPNGDAGPSTTNLGGLLSLTSPPINTGNTPHGFNMPPQHMMSMENNQFQMYPNELAPHVMPAMATNNLSTTGEYQFVLQQRLVEENQPLPSFAQIQAHRFNVIGYETANVGGRGSVTTPYTTYYETDISDMRPVLYRETDYKLTVVTPLESPTHQEYILGYPSDEHLHDHEEDLSMISMTSEHESKIMEENKMQIMEDIKLRLEAQPKSPEKAHTKRDYEENSIPLITSTSKPGLHKCYDCDKVFNKACYLTQHNKTFHSGDKPFKCSRCGKRFSCEVTYQEHLTKHAGDKPHKCELCPKQFNHKTDLRRHMCLHTGQKPYACETCGKGFIRKDHMMKHCETHIRKTQSKIAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4X5</accession>
    <name>A0A6P7G4X5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337702</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028144016.1">
        <property type="nucleotide sequence ID" value="XM_028288215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4X5"/>
    <dbReference type="FunCoup" id="A0A6P7G4X5">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288215.2">
        <property type="protein sequence ID" value="XP_028144016.1"/>
        <property type="gene ID" value="LOC114337702"/>
    </dbReference>
    <dbReference type="GeneID" id="114337702"/>
    <dbReference type="KEGG" id="dvv:114337702"/>
    <dbReference type="InParanoid" id="A0A6P7G4X5"/>
    <dbReference type="OrthoDB" id="17373at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027872782" description="lysozyme" evidence="7">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028144016.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16644" checksum="6F035C9FE5CFA999" modified="2020-12-02" version="1">MKSFAIFFCVVVIFCVSRAKVFDKCEIVTKMSKHGVPWSKIPTFVCLIKWESGFDSGKLDYKTGKHGLFQINEKVWCSPYTNPGRECNTTCSDFRDDHIMDDINCALKIFSDTLDLSGIGFDAWTSYWDHCAADDNMDYVEGCKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7X9</accession>
    <name>A0A6P7G7X9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic phosphatidylinositol transfer protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Retinal degeneration B homolog beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114334746</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140635.1">
        <property type="nucleotide sequence ID" value="XM_028284834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7X9"/>
    <dbReference type="FunCoup" id="A0A6P7G7X9">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284834.2">
        <property type="protein sequence ID" value="XP_028140635.1"/>
        <property type="gene ID" value="LOC114334746"/>
    </dbReference>
    <dbReference type="GeneID" id="114334746"/>
    <dbReference type="KEGG" id="dvv:114334746"/>
    <dbReference type="CTD" id="37011"/>
    <dbReference type="InParanoid" id="A0A6P7G7X9"/>
    <dbReference type="OrthoDB" id="10053061at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000011">
        <property type="entry name" value="cytoplasmic phosphatidylinositol transfer protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF54">
        <property type="entry name" value="CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028140635.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34948" checksum="9429C49F11DA919D" modified="2020-12-02" version="1">MVLTKEYRICMPMTVEEYHIGQLYMIARHSLEQSGDGEGVEVVENRECLDEKHGKGQFTEKRIHLSSRLPYWVQSVIPKIFYVTEKSWNFYPFTITEYTCSFIPRFNISIETKYENNNGCTENCLGLSPEKLAERTVDHIDIAYDEVSAKHYKEEEDPRFFQSRKTHRGPLVDGWRSNCQPIMCSYKLVHASFEVFGLQTKVEEFIHSCIREVLLLGHRQAFTWIDEWVEMNMEDVRKYESQLQSQTNSLLKQSAGSPSTSGPEASLVGVDGGGDGLQDKSLLGVTPPETPKSPTKKGYFSNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G900</accession>
    <name>A0A6P7G900_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114339251 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114339251</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145676.1">
        <property type="nucleotide sequence ID" value="XM_028289875.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505084.1">
        <property type="nucleotide sequence ID" value="XM_050649127.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505085.1">
        <property type="nucleotide sequence ID" value="XM_050649128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G900"/>
    <dbReference type="FunCoup" id="A0A6P7G900">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289875.1">
        <property type="protein sequence ID" value="XP_028145676.1"/>
        <property type="gene ID" value="LOC114339251"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649127.1">
        <property type="protein sequence ID" value="XP_050505084.1"/>
        <property type="gene ID" value="LOC114339251"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649128.1">
        <property type="protein sequence ID" value="XP_050505085.1"/>
        <property type="gene ID" value="LOC114339251"/>
    </dbReference>
    <dbReference type="GeneID" id="114339251"/>
    <dbReference type="KEGG" id="dvv:114339251"/>
    <dbReference type="CTD" id="40149"/>
    <dbReference type="InParanoid" id="A0A6P7G900"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10974">
        <property type="entry name" value="CE4_CDA_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000003">
        <property type="entry name" value="CLUMA_CG003232, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF1">
        <property type="entry name" value="VERMIFORM, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027748204" evidence="3">
        <location>
            <begin position="20"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028145676.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60913" checksum="082B700E623D6DB2" modified="2020-12-02" version="1">MADKRLWLCCFLLLTIAYAQDEDDDDSGEPQIDQLCENRPADEYFRLSTDGDCREVVRCDLNSDLKGGTRLAAVKCPTGLAFDLFRQTCDWKVNVKNCDIVEKPRKVLPILKTDEPRCPEGKLMCGNEECIDKDLFCNGKPDCKDESDENACDVDSDPNRAPDCDPTQCVIPDCFCSADGTRIPGALEPANVPQMITISFNGAVNVDNIDLYEEIFSGTRLNPNGCQIKGNFFVSHKYTNYSAVQDLHRRGHEIAVFSLTHKEDPNYWSQGSYDDWLAEMAGARLIIERFANITDGSIIGVRAPYLRVGGNRQFEMMTDQFFIYDSSITASLGRVPIWPYTLYFRMPHKCNGNAHNCPSRSHPVWEIVMNELDRRDDPTFDESLPGCHMVDSCSNVQTGDQFARLLRHNFNRHLNSNRAPLGLNFHASWLKSKKEFKEELIKFIEDMLARNDVYFVTNSQVIQWVQNPTELSGLRDFQEWKEKCDIKGQPYCSLPNSCPLHTRELPGETLRLFTCMECPNNYPWILDPTGDGFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G934</accession>
    <name>A0A6P7G934_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaoptin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114335323</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141348.1">
        <property type="nucleotide sequence ID" value="XM_028285547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G934"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285547.2">
        <property type="protein sequence ID" value="XP_028141348.1"/>
        <property type="gene ID" value="LOC114335323"/>
    </dbReference>
    <dbReference type="GeneID" id="114335323"/>
    <dbReference type="KEGG" id="dvv:114335323"/>
    <dbReference type="InParanoid" id="A0A6P7G934"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31450:SF4">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31450">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 19 LRRC19 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027763034" evidence="3">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028141348.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40537" checksum="F6D6E054502DA95A" modified="2020-12-02" version="1">MSHKIIFAVFTIVLLTLPFKAISACGGIKNVLIEVKDSESERSNITFSGCLERKNFGGKTITEIHIRNQNIPNIGWEYIKHLVRLDVLELNNCKIKNIARGALKNLPRIRVVEVTHNLITEVTGGIYDIFETIKILRLNNNKISSITDEALSNMTMTEVNFSHNEFREWKKVWFAYSPDIEILDFSFNKIESIPKRAFDGMPVLKEVDFSYNKISSIGKEAFRALKSLKVLNLKSNRLSSLNTNIFPRKITIGTLNIASNLFWKLDLKEHKELSLREIGIDHNPWSCPCMGNLHAWLNANKVTLLNSDNCGLSFLPICITADSCDTPPNGKGLENYLSVINSLDDLQKECIGLLVATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9Y3</accession>
    <name>A0A6P7G9Y3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allergen Tha p 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114337435</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143657.1">
        <property type="nucleotide sequence ID" value="XM_028287856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9Y3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655159.1">
        <property type="protein sequence ID" value="XP_050511116.1"/>
        <property type="gene ID" value="LOC126887527"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G9Y3"/>
    <dbReference type="OrthoDB" id="6732024at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028191410" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028143657.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15395" checksum="19666CCE47B48365" modified="2020-12-02" version="1">MNRWCLSALLVTVLVAVVYGKSFQDNIKILKKIDIETVIKNDRIIKGYIDCVTGKKGCTPEGAALKESWKEGIDKGCDDCDEEEKRKIKKVVKHIYLKHPDWYEEVANALDKDKKYRKKYQKYIDELVADPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAP7</accession>
    <name>A0A6P7GAP7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114335455</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_028141495.1">
        <property type="nucleotide sequence ID" value="XM_028285694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAP7"/>
    <dbReference type="FunCoup" id="A0A6P7GAP7">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285694.2">
        <property type="protein sequence ID" value="XP_028141495.1"/>
        <property type="gene ID" value="LOC114335455"/>
    </dbReference>
    <dbReference type="GeneID" id="114335455"/>
    <dbReference type="KEGG" id="dvv:114335455"/>
    <dbReference type="CTD" id="32257"/>
    <dbReference type="InParanoid" id="A0A6P7GAP7"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000576">
        <property type="entry name" value="CBN-SEK-1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028141495.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37551" checksum="F58CF174E4B2B149" modified="2020-12-02" version="1">MSGRKKKPGLKLQVSDDTVPKVVPPANLNTRTTITIGDRTFDVEADDLEKICDLGRGAYGVVEKMKHIPSETIMAVKRITATVNTQEQKRLVMDLDISMRSSDCPYTVQFYGALFREGDVWICMEVMDTSLDKFYAKVYKNGKKIPEDVLGNIALAVVSALHYLYSQLRVIHRDVKPSNILINRQGEVKMCDFGISGYLVDSIAKTIDAGCKPYMAPERIDPTGNPSQYDIRSDVWSLGISLIELATGDFPYPKWGTPFEQLKQVVADDPPRLPSGQFSPEFEDFTCKCLQKKYTDRPNYSQLLEHEFLVKHKDIKTDISPFVSEILDIPDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFC0</accession>
    <name>A0A6P7GFC0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vesicle transport through interaction with t-SNAREs homolog 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114341700</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148306.1">
        <property type="nucleotide sequence ID" value="XM_028292505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFC0"/>
    <dbReference type="FunCoup" id="A0A6P7GFC0">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654519.1">
        <property type="protein sequence ID" value="XP_050510476.1"/>
        <property type="gene ID" value="LOC126887156"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GFC0"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF89">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
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    </dbReference>
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        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028148306.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13027" checksum="EE034AA91520A2B5" modified="2020-12-02" version="1">MYRDNEDFEERNRQILFQGTAALERTGESLARSTQIAIETETVGTEVISELDSQREALLRTRNRLGDANEELRNAKSTLSAMGRNVLYNKLILILIIILEILILAAICFIRFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GH30</accession>
    <name>A0A6P7GH30_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114342491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114342491</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149101.1">
        <property type="nucleotide sequence ID" value="XM_028293300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GH30"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657281.1">
        <property type="protein sequence ID" value="XP_050513238.1"/>
        <property type="gene ID" value="LOC126888851"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GH30"/>
    <dbReference type="OrthoDB" id="6759257at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027679052" evidence="1">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028149101.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="18473" checksum="C066110AA35E9BAC" modified="2020-12-02" version="1">MYFSRCVQLFLCVILFYQISSIKAQCVGRFTIEDEEDNDILYRFMDTLERYTGLSGDYQKAVTVNCPRNGICVVNPQGSAIWEARLEFYTPYVLNSSGTHSSTETLDSCICYSRTNYEFQDCLINVRQNMLLDLDTKLVPTFRRIVEQDRCALFKENCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMK1</accession>
    <name>A0A6P7GMK1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tenecin-1-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="13" type="primary">LOC114344222</name>
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    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028150869.1">
        <property type="nucleotide sequence ID" value="XM_028295068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMK1"/>
    <dbReference type="FunCoup" id="A0A6P7GMK1">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295068.2">
        <property type="protein sequence ID" value="XP_028150869.1"/>
        <property type="gene ID" value="LOC114344222"/>
    </dbReference>
    <dbReference type="GeneID" id="114344222"/>
    <dbReference type="KEGG" id="dvv:114344222"/>
    <dbReference type="InParanoid" id="A0A6P7GMK1"/>
    <dbReference type="OrthoDB" id="10038290at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028431408" evidence="9">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028150869.1"/>
        </source>
    </evidence>
    <sequence length="97" mass="10713" checksum="E4DBA2AA121A499D" modified="2020-12-02" version="1">MKCAIFAIFVLAIVAGINSSPIDQEEPKVIPPDVFIPEDYNPEQKEEHSRVKRFTCDVLSVEAKGVKLNDAACAIHCLTLGKAGGWCDNHKVCNCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNG5</accession>
    <name>A0A6P7GNG5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114344547 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114344547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151179.1">
        <property type="nucleotide sequence ID" value="XM_028295378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNG5"/>
    <dbReference type="FunCoup" id="A0A6P7GNG5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641279.1">
        <property type="protein sequence ID" value="XP_050497236.1"/>
        <property type="gene ID" value="LOC126878525"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNG5"/>
    <dbReference type="OrthoDB" id="8174264at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027717140" evidence="1">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028151179.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20451" checksum="E6F1D20648E944E4" modified="2020-12-02" version="1">MNQIGLLSLTLVLFQCVIFLDQPAETAAQEPAFELPVELIGFPVIIVAVRLSNFVKKLAYSLNPSTYRRTRRAISSDEMINMIEAEKRLVSELGENVCIYPKVCLHHAEKASKSKGRQEIAIDWDEVFRNYKASPEKNKEFYLLSVFLGDFIQSPKFCNQLVKRGRACKDEIGSSSKLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTA9</accession>
    <name>A0A6P7GTA9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-related GTP-binding protein RhoU-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114342657</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149267.1">
        <property type="nucleotide sequence ID" value="XM_028293466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTA9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647936.1">
        <property type="protein sequence ID" value="XP_050503893.1"/>
        <property type="gene ID" value="LOC126882877"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GTA9"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001600">
        <property type="entry name" value="RhoU, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028149267.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25946" checksum="506FD4F272D653CD" modified="2020-12-02" version="1">MMTPQSTPVLHYTKQPLLPQNNHVTVFNPKKTRKVKSDSKKKIKCVIVGDQAVGKTSLAVSYSNDSFPSEYIPTAYDNYNVQVQVNGKPVRVELCDTAGEDELDPLRHLCYPGTDVFMLCFSIVKPHSFFSACSRWADELTKQEAAVVLVGTQADLKANVEVLNRLRLYGQRPVMQSEARGLAERLNAPYIETSALACTQLKEAFDTAIVIALDRQKRKTRPWRKLLCCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZ40</accession>
    <name>A0A6P7GZ40_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450 4C1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114344051</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150703.1">
        <property type="nucleotide sequence ID" value="XM_028294902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZ40"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646090.1">
        <property type="protein sequence ID" value="XP_050502047.1"/>
        <property type="gene ID" value="LOC126881683"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GZ40"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028150703.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57451" checksum="A5EF9F1CB6138DF4" modified="2020-12-02" version="1">MIILILVLCVIAIFLYREYTHHKYWKYINEIPEPKGLPIIGHYELMNLGSEELFRLIRQRSKEFHPIYKTWSFEMYFIQLSGPPEDMELILGHSENNDKSFIYNFLNNWLGTGLLTSNGSKWHSRRKILTPAFHFNILQKYLEVFNKETEILLDELDKAAGKEYINVLKPITDFTLFSIGESALGVSLREKNCDEYKKAIHEYGKIGAYRIMKPILYLDFIFNMIPVGRTLKKYIKTLHDLSTNIIREREQSKQMDGEGNLSYSKRKRLALLDLMLEARAAGENIDEEGIREEVDTFMFEGHDTTSVALCYILLNLANEQEHQAKVYEEIQSVLGTTQYPTQQQLGELRFMERFVKECLRLYPSVPFISRKTGKTVHTHSGYTIPKNSTVFIHIYDLHHDATVWEDPERFDPDRFLPDNVAKRHPFAYLPFSAGGRNCIGQKFAMLEIKAVLCGILRKFKLESVDKREDIKFIADLVLRPTGEIRVKFSHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H898</accession>
    <name>A0A6P7H898_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114345541</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152160.1">
        <property type="nucleotide sequence ID" value="XM_028296359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H898"/>
    <dbReference type="FunCoup" id="A0A6P7H898">
        <property type="interactions" value="1138"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649588.1">
        <property type="protein sequence ID" value="XP_050505545.1"/>
        <property type="gene ID" value="LOC126883887"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H898"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028152160.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="20832" checksum="ACBE7AA7216DFA5E" modified="2020-12-02" version="1">MPEVDIEWPWQYNFPPFFTLQPHPETRAKQVDAWKSLILNFCEQTKTYTLDVRDTNQSPLFNNSSINRKLEQNVIISILSELQKSGHASPVDKNKNRWEIYWHTQEEWASIVYDSICERGMQNTVVTLFELTQGEDVSDAIFFGMNQEVLIKVLRVLENERKCELILEDEIQGAKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HC04</accession>
    <name>A0A6P7HC04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-catenin-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear-associated protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114346753</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028153305.1">
        <property type="nucleotide sequence ID" value="XM_028297504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HC04"/>
    <dbReference type="FunCoup" id="A0A6P7HC04">
        <property type="interactions" value="2489"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641810.1">
        <property type="protein sequence ID" value="XP_050497767.1"/>
        <property type="gene ID" value="LOC126878929"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HC04"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028153305.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="64217" checksum="706220F0642833A9" modified="2020-12-02" version="1">MDVEELLDYKPPQALKRPVQVDEEEDEAERTRKMRRLARAKASRMARPISPTPSTQPLDHISEEERAEILKFVETEQTQGEIIDETALKKIVLNFEKRSLKNREMRIKFPDSPEKFLESEVELHEILQEMRILATAPDYYPLLIKLQVIPSLLELLSHDNTDIAVATVELLQELTDVDSLNESEEGTEALIESLLDHQIIALLVQNLERLDETVKEEADGVHNTLSIIENLTELSSEIINEATKQGLLAWLLKRLKLKTPFDPNKLYVCEILSILLQNNEKNRLALGDTDGIDTLLQQLAFYKRHDPTSSEEHELMENLFDCLCSALMVFPNRERFLKGEGLQLMNLMLREKKTSRNGSLKVLDYAMSGPQGKDNCNKFVDILGLRTIFPLFMKTPKKNRRKVLSTEEHEEHVCSIIASMLRNCRGSQRQRLVSKFTENDHEKVDRLLELHFKYLEKIEAIDDTIEEDNEEEDAVYLKRLEGGLFTLQLVDYIIVEVCAAGPGSIKHRVMQILNLRGASLKTIRHIMREYAGNLGEEGDKEWKDQEQQHILNLVDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IB84</accession>
    <name>A0ABM5IB84_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a heterodimer with PSMG1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129054.2">
        <property type="nucleotide sequence ID" value="XM_028273253.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273253.2">
        <property type="protein sequence ID" value="XP_028129054.2"/>
        <property type="gene ID" value="LOC114325247"/>
    </dbReference>
    <dbReference type="GeneID" id="114325247"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129054.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="238" mass="26791" checksum="AB0465CF8876F501" modified="2025-10-08" version="1">MPELLRYSKPTNLSDFVIIIPCVSVGNVPQLAVDLLIKTYNLEKVASVWHSSIVPTVGADPYNCSSSEICTACELYSNEDLKIACFQLRSTIETKTARKFFEDVYNSLKELKIKKVVVLSSAFDYELHNIKQERFYFLGKSQTNLSNIPNMKELEKGDNNKYSVNGAGFAINLYSVLSRSLDCLLLGKYISEGDNRPDAQSLLEKVLYVTNLQRISKNVVYPSSWDYVFGAPPPIGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDU1</accession>
    <name>A0ABM5IDU1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein asteroid-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130645.2">
        <property type="nucleotide sequence ID" value="XM_028274844.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274844.2">
        <property type="protein sequence ID" value="XP_028130645.2"/>
        <property type="gene ID" value="LOC114326463"/>
    </dbReference>
    <dbReference type="GeneID" id="114326463"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130645.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="86615" checksum="629705D29FBB497A" modified="2025-10-08" version="1">MGIRGLTTFIQNRAHLYLENYELHDTNVVIDGNSIACQLYKWHTFSHDCFGGDYDKFSRAVHNFFDLLSQCNIIPYVVLDGGYEHRKVNTVISRMKKKIKSANQLNCVTETSISVFPLFIRQTFRDVLTERNIKHVGCDFEGDTETSNIARTLNCPVLSFDSDYFIFDVLYIPFSTFEMAVKRGKSKNTTTYKYIACNIYRVEKFLKSFNGLQKNSLPVLAVLLGNDYVKRGVFTMFYQNLKIQKCHGIQSDQQKRIKSLLVWLQNETVESALKKVLSRYKKGRRNIIMYKIKQAIKGYNCFDSKYLKYLGIEPKVVDKKNVDIDLETINNSIEEPDESESHTEVEDTGGEPDKSESQSEAEDTGGESSPPEEDNLFVEESPEMGVPSRFLEKFRTCIYPPCFMDILIQNKYYCIPQVDNNALEHSHKICFDILSAIHKILSNSNENLLCIGRKGAEGVAKEKVPICDISLPSYNEIEALSNSESTKYIFNILGVDNSYEDCLKMFPDSWHTLLLSLYYYLKKSTTSFGWPIVYGIILSRLILSCVDIKLGTFFRSSKVFCKKFGNFVSDNKHNETVVQDVKGALDTISQPDSILCLKALISYFEMDHKMTTNYKSFDRSLVHSISEFQSCFMHVDYLNVLFDCPFSNFYISKTLNCTFVYNITKNLTKRTNLDEYMKLVLKDSPSVLYSLNVIVSAMKKFIQIEAPQQVIKKRRKKKTAKEVYEEAEKIEFDSDEEAEFDPNNKFALLRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE32</accession>
    <name>A0ABM5IE32_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component 110-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130782.2">
        <property type="nucleotide sequence ID" value="XM_028274981.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274981.2">
        <property type="protein sequence ID" value="XP_028130782.2"/>
        <property type="gene ID" value="LOC114326579"/>
    </dbReference>
    <dbReference type="GeneID" id="114326579"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130782.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="49261" checksum="03BFE651B1C5AD8D" modified="2025-10-08" version="1">MQDGNNNQEKYFTPKGDGDGVQKFTPRKRYPVPSARKFSARAPRDENMKDKLEQTLEEMSFKVKKHNCLVKAQTVAEITPTKSKRKKTYRQCLKLNFDGDAPDLDTTLQVALHATPRPLDGTPALASQAQRRRCTRDWAVCTVYQRLLLFVWRRTKARLQTLSESNGRQQNQISQLELQVDFMNSMRKSECEKRNQALQKCHSMSQEVSVLEITNNNLMQELKIIKEDLLNTKKNLTLTKHDLIKTTDQLSKSKEQAMRRREEKMDLISKLNCTEQQVSSQNEKIVELEEKYKMIENNRHNMESNFKNKQKELEAVQEQYQLEVKLNDSLKDRMASLENTKVELERRVKTLENELMVYIDGIENLEDENIMIRENLAEVTVELFEEKKKKWVKITKELTLLSLSALQKIIEVMLPVYHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IE80</accession>
    <name>A0ABM5IE80_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130902.2">
        <property type="nucleotide sequence ID" value="XM_028275101.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275101.2">
        <property type="protein sequence ID" value="XP_028130902.2"/>
        <property type="gene ID" value="LOC114326686"/>
    </dbReference>
    <dbReference type="GeneID" id="114326686"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="316" mass="36251" checksum="A532FCDEC942069A" modified="2025-10-08" version="1">MNPVYDFIQKNRVLALIEKAQKSSARNLALDDFDLTQFPEVLITCQGLHILNIGHNRIVEIPMEISQLKNLQHLSLEYNQLDRFPEALKHCPQLVSLNLSHNPVKELTRDIGCLVSLEMLWCNSCCLTSIPEEIGNLTKLETFGARHNKIVKLPNRIGELVNLRWLTMEDNCLNNVPHNFGKLELVKHINFNKNNFSYIPYRFAKLKNLKYLHLQSNEFFVLPVRTISAMPNTRFNFQNNPVGLEDYKIFTNVILSGTEDEILDMFGYDSDSSSDDWDNSLDSADLNYSATDDDSDNENRDVIGNIPILSKFLVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IID8</accession>
    <name>A0ABM5IID8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chymotrypsin inhibitor-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133517.2">
        <property type="nucleotide sequence ID" value="XM_028277716.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277716.2">
        <property type="protein sequence ID" value="XP_028133517.2"/>
        <property type="gene ID" value="LOC114328760"/>
    </dbReference>
    <dbReference type="GeneID" id="114328760"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046922375" description="Chymotrypsin inhibitor-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133517.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9477" checksum="A40407CF50325931" modified="2025-10-08" version="1">MKHIILFTFLILAVAKIHCQDGLRDNTDQCGPNARFVLCTGCCEEETCEHRNPSSCNNCPAVCRGPGCECLPGYIRKTKGGPCVKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMQ8</accession>
    <name>A0ABM5IMQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 13-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136642.2">
        <property type="nucleotide sequence ID" value="XM_028280841.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280841.2">
        <property type="protein sequence ID" value="XP_028136642.2"/>
        <property type="gene ID" value="LOC114331312"/>
    </dbReference>
    <dbReference type="GeneID" id="114331312"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136642.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37044" checksum="5E8C683F9DBE83F9" modified="2025-10-08" version="1">MTMFVTSVFYWPVLLIIGAFFLNLFFKYCCMKCNSNVCLVGKTAVVTGGSLGIGHEIVLSLLSRGCKVIVADKIITESVKKSLIQKTKSSNFVLELVDFTSFKSVRNFVEKLKKTEEKIDILINNVGIGRCDNKPTEDGLNVLMQINYYSPFLMTHLLIDLLKKSEEPKILFTSSNLSFFHEHCVKSITDDNIIISNNATTYIASKFFTVVASDIFAKKLRKHNIMCNSYHPGVVKTNIFNETRKYATSNMLDVVFMFALDVIVFLAGQSPRDASQTAVNVVVSEEFKNVTGEFIGVTSIKPRGSHDEVLCNKIWNASEKLVKLQPNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQK1</accession>
    <name>A0ABM5IQK1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138874.2">
        <property type="nucleotide sequence ID" value="XM_028283073.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283073.2">
        <property type="protein sequence ID" value="XP_028138874.2"/>
        <property type="gene ID" value="LOC114333217"/>
    </dbReference>
    <dbReference type="GeneID" id="114333217"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="172"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138874.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="311" mass="35032" checksum="662A66256F62EB9D" modified="2025-10-08" version="1">MSRQHWDEFYAANSPPANYEDSQKQIKLFCEKHHHNNQRIVLVTSGGTTVPLEHNTVRFVDNFSGGVRGAASTEYFLKRGYAVIFLHRLKSLEPFTRHFGGQKFLEMLDIDKNEQGTSITVKPEYIKEVAPILVSYKTAHQEGRLLCVNFTTLSDYFWLLRAACESLTIFGTNAMLYLAAAVSDFFIPPNQMSTHKISSDAAPSIHLQLVPKLLTPIVSDWLPHAFVVSFKLETDQNILISKARGAIDKYKHKLVIGNMLHTRRTGVIFVKPDTSEEVKITPEQAASGIDLEDSIVTKVIAEHSLFIEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQN6</accession>
    <name>A0ABM5IQN6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138967.2">
        <property type="nucleotide sequence ID" value="XM_028283166.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283166.2">
        <property type="protein sequence ID" value="XP_028138967.2"/>
        <property type="gene ID" value="LOC114333306"/>
    </dbReference>
    <dbReference type="GeneID" id="114333306"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138967.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="26008" checksum="62AB636AA49A4AB9" modified="2025-10-08" version="1">MASNLEELFRKSKKVFRSPNKTPNEDNKLDQIIKMMHDLTKETKNLTTEVKEIKNEQRKYWEELNDLKTELEKVKQENQTKHKEKEEMKKELNDMKIRVQRLEKERKVNNVVIQGLTIDTIDRNALKQAVGNFMEKEMNINVQIEEAIKLGEKTCLVKLQNKFEKEKIMQNKAKLKHIKDYKVYINNDITKEELQTQKSIRQVANEEISKDLDSLYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZB4</accession>
    <name>A0ABM5IZB4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151799.2">
        <property type="nucleotide sequence ID" value="XM_028295998.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028295998.2">
        <property type="protein sequence ID" value="XP_028151799.2"/>
        <property type="gene ID" value="LOC114345141"/>
    </dbReference>
    <dbReference type="GeneID" id="114345141"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF169">
        <property type="entry name" value="PROTEIN ATONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028151799.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="124" mass="14621" checksum="740341697B2E3D90" modified="2025-10-08" version="1">MEYYVDQFEYSYMVPVPVGSPSDWSTGSSYDSFADENKLLNSEIVRKKNTVTPLVIKKRRLAANARERRRMQNLNQAFDRLRTFLPQLGQDRQLSKYETLQMAQTYISALYELLDQEERPKSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHF8</accession>
    <name>A0ABM5JHF8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497373.1">
        <property type="nucleotide sequence ID" value="XM_050641416.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641416.1">
        <property type="protein sequence ID" value="XP_050497373.1"/>
        <property type="gene ID" value="LOC126878604"/>
    </dbReference>
    <dbReference type="GeneID" id="126878604"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="59300" checksum="86305D5EEE1BDE3D" modified="2025-10-08" version="1">MGASLDELASILDTSEKKILKREFSHLDDDTFNLLTCKGVFCYDYIDSVEKLDETSLPNIRYFYNKLNNEYISEEKYAHAQSVWNKFNCKNLGEYSDLYLKTDILLLADVFEQFRQKCRDTYKLDPAWYYTMPGYTWDCMLRYTKCKLELLKDVDMILFMEKAIRGGISVCSNRYSEANNKYMSTYDPTQPSKYIMYLDVNNLYGWAMSEALPIGGFKWIEDGTKFGVASKSTNLPEGHIDIMSIPNDAKEGYFFQVDLEYPRELHDKHKDFPFAAEHRIPPGSKLPKLIPTLYHKTKYIIHYRNLKQALENGLILTKIHRVLKFKQSAWLRPYIELNTNLRTAATSSFEKNLFKLMNNAVFGKTMENIRRHRIVKLCKKWHGRYGAKNLIASSRFHSRTIFHENLVAIELKKSEVCFNKPLYIGAAILDISKLCMYDFHYNFMLPTMGEENCSLLYMDTDSFIYELQCSDAYREVLKAYPSKFDTSDYAENNPYDIERLNKKSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJ12</accession>
    <name>A0ABM5JJ12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497930.1">
        <property type="nucleotide sequence ID" value="XM_050641973.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641973.1">
        <property type="protein sequence ID" value="XP_050497930.1"/>
        <property type="gene ID" value="LOC114347014"/>
    </dbReference>
    <dbReference type="GeneID" id="114347014"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="163"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="642"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="102608" checksum="9BBF3096A530285C" modified="2025-10-08" version="1">MNDCVELRKRQAILTQAIKSGKREAFKSFLAKLDFRKDGVKAHRFVTTLNNDGNKQQQMPMRGMARELTTHADIANELCKHYTKVSNIKINKREKARLLRYPPPRRMSKSIKDICTEDFSISELEAALSDTKTKKAAEIDELYPEMLKYLGAAAKNTILNLINLTWNSRVPSQWRKSEVIPTLKKQKDPSLTDSYRPISLTSSLCKVAEKMVLDRLNRAITHLELIDDAQAGFRKHRNTMDHVVEFAQKVKDAFHRKMSTVAVLVDLKAAYDIVWRGLLLHKIAKSGIDGKLFNWIKSFLGERYQRVKFHNHYSKFRLQRQGLLQGAVISCQLFNLMINDVLAMIRRTPGVDALLYADDLLIWASSSSLKALEGVVNQALKNLEKWADENCLTVSTTKTLYQVLTLSTKQTAVKLTYKGVDLEREDVTKYLGVYIDKKIAWKPQIDDIAEKATKRCRLLKRLTATKWGATQDVLVATYKTYVRPILEYGSEATITASTNTTSKLEVAQNTALRVITGAPKSTPITSMEAQTGIEPIQCRREQHALTFWERQRRILPQKWDEYRQAASRLKTQTTPLTVANQIMEKYHIDLSKAAPFPAQTTLARGLPNTELRLENHNDPKHLSSDIVLRKAALETIHTNYPAHEWLHIYCDGSSMPDSGRTGAGYVSTFSKGSIAVGAPLTNYDGEIAAIHEAAKSLENLQHPQKVAFFIDCQAAILALSTNRYTDCAQTISCRVQLSNLLEKGWLITLQWIPSHVGVEGNEAEDELAKEGTTLPQPPSFQSYTSAKSTIKRGIKAKIKDQQIQAGAGKSWAHLIESPIPHNLPRPISVAAFRTTTGHDYLASHLHRIGVRENDNCPLCNQPQMDAAHLPECPALITDPPEEDEDRLRETARLYWSARRQMANMPRVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK56</accession>
    <name>A0ABM5JK56_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498323.1">
        <property type="nucleotide sequence ID" value="XM_050642366.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642366.1">
        <property type="protein sequence ID" value="XP_050498323.1"/>
        <property type="gene ID" value="LOC126879298"/>
    </dbReference>
    <dbReference type="GeneID" id="126879298"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40427" checksum="688B675CFF6CDCB5" modified="2025-10-08" version="1">MIQNFQISLLSSGNTQEFGQYFQKCYLHNMESWAYCYRLHAGINTNMSIERMHQTIKYLYLNGRQVRRLDKTINILIKLIKDKLFERLITLNKGKISSKLRELRKRHKTSLNLDMDTIVMSEMGWEIPSSSTNDIYLVQKNKPSCDCRLVCDLCQSCLHSYSCTCLDNSIRWNMCKHIHLVCQFMKGHQIQDTNADEEHIINTDEVKIKQATEQAKFVEFVSKSCNINQEKTSKQLEVEKQKLIEIQTQIIQNITTFEQLEAFKSITAPLVPTLRTLAEHSGNELNIVALSHGTQNIPHNKKVVAQKRLFSTKKKTTKSKKKLLSKPDAEETNLIANQLMLQVNNVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLS7</accession>
    <name>A0ABM5JLS7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Jerky protein homolog-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tigger transposable element derived protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498891.1">
        <property type="nucleotide sequence ID" value="XM_050642934.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642934.1">
        <property type="protein sequence ID" value="XP_050498891.1"/>
        <property type="gene ID" value="LOC126879722"/>
    </dbReference>
    <dbReference type="GeneID" id="126879722"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61297" checksum="8DC81F10E15252A7" modified="2025-10-08" version="1">MAAKRKNVVVTMEKKLEALGRIDKGESLKTVAASYGVVTSTVSDWKKNRTKIEEFCFKMITKDSLDNRCKTNKAKNETLDDALYVCFCAERERGLPVSGPIIQETALKLNKMLPDCEPDFTASQGWLDRWKKRHGIRQLSITGESLSGDNNAAHDYKSKFLDFVREENLTADQIYNADETGLFYRMFPSKTLASKTEEAAKGYKKSKDRLTIMACSNASGKHKFPLVLIGKSKNPRALKNVNRDYLPVVYQSQKNAWMDSTTFKNWFFDCFVPGVTKYLKDCGLPNKAVLIIDNAPSYPSADVLVSGDITVKFLPPNVTALLQPMDQGVLEKIKKVYRRQMLSTIIEDEGQHGVVEVLKTFNVKTVIYMIAESWEQVTTISLIKSWKKLWKGVCDLPENSIQPVDNCYLENDSPDEVQSQELLNMFQNIDGCSEVDESDINLWLEADNNGGYAPLTDEAVIALCLPDASESDAENADGDIEQPVMSHGDAMTQLDALMVYFERQAETSPAELLMLKRLRDRTARKRQTKLTQPKLTDFFITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRY0</accession>
    <name>A0ABM5JRY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500698.1">
        <property type="nucleotide sequence ID" value="XM_050644741.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644741.1">
        <property type="protein sequence ID" value="XP_050500698.1"/>
        <property type="gene ID" value="LOC126880702"/>
    </dbReference>
    <dbReference type="GeneID" id="126880702"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="468" mass="53769" checksum="BD85246C2936A38F" modified="2025-10-08" version="1">MSKSNYSEIWTYFTPICDAERAKCKLCNKEYSRKGRTTTAMRNHLKAMHKTEFSKLEECEKRKQDASKSLEQASSSHQIKSFMKQISFQECVDKTKQWDNNSAKSLEVDNFISEMVALEDLPFRFVESVGFVRLIKHLCPSYNLKSRQYFTSFICDKLFCKVSEKILQLLKSFEKLSFTTDIWSDTCSGVSLLSLTCHGITKEFERKMIVLKAEVFNEGRHTGENIAHKLEDILSFWEIPKDKVKCVVRDAGANMKKGVNLLNVEHIDCASHKIQNVLKAGMKAQETVVSAITKCKKMATHFHHSTSAQDELTSIQKRLNQKPLKTIQECTTRWNSTFYMLERILQVKESLCLYASANNKIPQLASDEWMIIEKLIGLLRPFEEITKELSASDVSISSVIPLITTLEKVVHDLDSSDEHIGDTITVLKDELIRKFSGLENEILFSTATFIDPRYKSKFFKIRRLKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS30</accession>
    <name>A0ABM5JS30_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500748.1">
        <property type="nucleotide sequence ID" value="XM_050644791.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644791.1">
        <property type="protein sequence ID" value="XP_050500748.1"/>
        <property type="gene ID" value="LOC114327294"/>
    </dbReference>
    <dbReference type="GeneID" id="114327294"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="188" mass="21619" checksum="8316427D439E5E3F" modified="2025-10-08" version="1">MKGVIGSIIPILNKERRPSLITIDRPYYTRHHRPSITIERPYIHQPRSRRLSCFAERPQGRHRNFISFEHSFDRKPLEKPSCSYHPAISFETPMESMELPTLPVEPPSLPLFSNTGAIPKTSRSFEQPRLNRDKSKSDRSSHSLDVSSISFDRRCSIPEEDRGSPVYIHLDETRITAPLLEGLKSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSC8</accession>
    <name>A0ABM5JSC8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500835.1">
        <property type="nucleotide sequence ID" value="XM_050644878.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644878.1">
        <property type="protein sequence ID" value="XP_050500835.1"/>
        <property type="gene ID" value="LOC126880814"/>
    </dbReference>
    <dbReference type="GeneID" id="126880814"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="389" mass="44278" checksum="3BC2EA74FB023B0B" modified="2025-10-08" version="1">MLTEVNNLSSRIENISRRKVEYKDTDFGPFLIMIESDKGKAGNIHPMDIGKVFHTMGTTGIKEISRKGMNRIGVIFNTSKQANMLLNSTEILEKGFLAYIPQKMLTSRGIIRDVSINISMENIVNDSKLQKNAKIISARRLNRRVLDSNGTVTYIPTGTVQLLFDVRTPPKEIIIYSNLVAVDPYIPPVQQCFKCLRFGHSQRQCRGKARCPKCSDEHTFQNCTVSVPKCLYCDLEHLATNKMCKEFERQKKINEVMVFQDLTFFEAAKLFPPIKEKPENSRMFQRRSRDFPSLLSSSPRAFTQALQKSPSSTSHFQSQSHVVPVKRKNKVILKDISYDKEAHKALLNEDLSRNLPRLPILNKFNDSQKYMGSQGPSFALSLTSNPVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT75</accession>
    <name>A0ABM5JT75_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING finger protein 207</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501138.1">
        <property type="nucleotide sequence ID" value="XM_050645181.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645181.1">
        <property type="protein sequence ID" value="XP_050501138.1"/>
        <property type="gene ID" value="LOC126881124"/>
    </dbReference>
    <dbReference type="GeneID" id="126881124"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19814">
        <property type="entry name" value="Bbox1_RNF207-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039320">
        <property type="entry name" value="RNF207"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22635:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="797"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="857" mass="97423" checksum="526D17C450313D53" modified="2025-10-08" version="1">MEPPGMDSGLEFPKNPLLCPICHDYFTEPCILNCYHTFCARCLRGRDQDRRLICPFCRQPTTLKDGSTLPPPDSLMRQLIDIANSENPPCSNCDKRDRSNMYYCNTCGQALCLHCRENTHRAKMFSTHDVVHMSKCAKEAKKCALHGEHYIMFSPLQNTMLCVNCFRDLPNEMRTQCVDIDTAHAQAAKRLERGQNAIMDLQTSVRDGIIALKGLMDELRRNMDSEKHTINTFCHGMQEAMAKTHATMIMEVQRQYESKERIYRSQLVVLGTVMPVLQLHLVLCTTFTAAANKYQFLELCPSLIERLSAVGNLSQPVRSLQSSQIKTNYRSEFAQSLEPWIGPAAVSQHQSELAATSRMYDSVPPATKKQQTALKNKLLDGDSSFSTHCRSFESQIRDLNQQFNSIKEKVGELHKDISALRKAQTPPLATRYEMLIRECLHLDQSLERQQKELDRMASAFDASWEEQLWRLRVEQEVFSCQRADVNTLRNELKHISQVVATQLEPYIRSLTPAQQQQQQQQGQTEQTQVSQAEQAQHLASLLEHIGLLQQSDSSMGKIPRSRSRVLGQLLEKVRPNVQERERSKSAGQVDKPLTTTSQKATPKKPFISSQQMNIDRLEAQIKEKIQDILSRRQSQPSSKSDTETERKLAKDDRKMSSTDSIGKLNSKQRIMYKKINKSCDKINTGSKSDSETRKSRSESDYQRISDATSQNLKGLVHGSRSSPSSPKCKNKGLLATKPQKKKVYPYSDGEDNVFYSMHDSADSLSTSSRRSSFDGPDKTLVVVINRRNKNMTMAQKQRSWETFPPKRKHHVCHQKLSVPTPPMAPIRKADSFEGHEEAVKSLVAAVQETRRKPRSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVM8</accession>
    <name>A0ABM5JVM8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501995.1">
        <property type="nucleotide sequence ID" value="XM_050646038.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646038.1">
        <property type="protein sequence ID" value="XP_050501995.1"/>
        <property type="gene ID" value="LOC114335298"/>
    </dbReference>
    <dbReference type="GeneID" id="114335298"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="7">
        <location>
            <begin position="241"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="373" mass="42634" checksum="928C948BB2680508" modified="2025-10-08" version="1">MNFYSMRRRVVKVAILTAVVTTAACLIISLVLLTDKHNIFQKREIQEQEQEQSTKPILRNSIQCYRSKIESIPDISDSHPRKDKSIFFHESSCKSYYNNKIFINARQACAVESAATLNPNLDVYLLYSSPGIFKYDGHESDDLLEAILSYENIHVMHVDFERYIEGTPLESLYKNGKIEQSNYAISHASDILRFLSLWKYGGIYLDLDTISIKTLDGLPLNFAGLETNVSVNSAILSFNSSDYGHVLAEKCIMDLKRNFNGRLWANNGPGVITRLIRSICGVEKRQAIQANTCQGFRLFSESAFYPISGPSWEMYFNETYLNEVLKKTSSSYVLHIWNNNSANRKLPVDSKAPYLYFAKKYCPKVIEVCTDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVP4</accession>
    <name>A0ABM5JVP4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502006.1">
        <property type="nucleotide sequence ID" value="XM_050646049.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646049.1">
        <property type="protein sequence ID" value="XP_050502006.1"/>
        <property type="gene ID" value="LOC114335305"/>
    </dbReference>
    <dbReference type="GeneID" id="114335305"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047315860" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="62"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="324" mass="35701" checksum="86FEBFE58F5BF35F" modified="2025-10-08" version="1">MRKKLDTVFLWILTFTINGFDALKLDFGNCPIYFEEPCSPYATKFILSIGKGENVTYHDLDPYEPVIPKEFNHLLPFKVVIHGYGGLKVDTAITNVTVAYQSVGYNVVIVDWEPISSIPCYITSYLNTWHVGQCLAILAMNLFPYGISPLLTHIVGFSLGAHIAGFAGSNIRNTMGLSFMRITGLDPALPFFATFNNDWKLDSSDASFVDVIHTSAGTFGKLEALGDADFYLNGGSLQPFCHSAKYPPICSHILAGVYFAETIRNPGSLFIGTKCDNLASYYLGFCRSGEVALMGEYTHISTNGIYFVKTSNKPPFALSILQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JX56</accession>
    <name>A0ABM5JX56_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein bric-a-brac 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502521.1">
        <property type="nucleotide sequence ID" value="XM_050646564.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646564.1">
        <property type="protein sequence ID" value="XP_050502521.1"/>
        <property type="gene ID" value="LOC114336046"/>
    </dbReference>
    <dbReference type="GeneID" id="114336046"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="472"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="527"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="74641" checksum="BBE21A260452A1A8" modified="2025-10-08" version="1">MISGHWLTGSETMDDQHYCLRWNNYQSNMTSVFHQLLQNEDFVDVTLACNDLSLKAHKVVLSACSSYFQKLLLENPCKHPTIIMPQDVGYEDLKFIIEFVYKGEIDVSHAELQSLLRTADQLKIKGLCETPDDKDNKDLLDTPDLVPLSLHCKSGRKSPSTKHSKFQSQELSPPKAKYPKTTFQAVLDSNEISGEEEDGEEGADKEEGNSGEDREKENEKAGGSEQPSSDENEKDDMPVALEPQPEPKRKRPISQQSDQNKPLNMSSHGLLSGQTIFSHFGVDDDFPPEPPAPSAIPVGHVDMSTAPVDHSPTRTILSEPMHRTDISDSTKYTLEIKKEADIKLETLRSYDQDSLLDMESHLSGPDHSMDSHDDGERTMHQLIGHADFSGIPGVSKLDVGDDVPGMKNNGHLELGQQRSHAGGPKTWTQEDMDMALDALRNHNMSLTKASATYGIPSTTLWQRAHRLGIDTPKKEGPTKSWTEENLNNALEALRTGTISANKASKAFGIPSSTLYKIARREGIRLAAPFNAAPTTWTPEDLEKALESIRTGQTSVQKASTEFGIPTGTLYGRCKREGIELSRSNPTPWSEDAMGEALEAVRLGHMSINQAAIHYNLPYSSLYGRFKRGIKYEADTIDYVDLNQDSHLQMEHTFGMEYTTSPSQIQYQNQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZ64</accession>
    <name>A0ABM5JZ64_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503224.1">
        <property type="nucleotide sequence ID" value="XM_050647267.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647267.1">
        <property type="protein sequence ID" value="XP_050503224.1"/>
        <property type="gene ID" value="LOC126882369"/>
    </dbReference>
    <dbReference type="GeneID" id="126882369"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="85" mass="9920" checksum="58BEB1A65848F106" modified="2025-10-08" version="1">MKVTITNWKGVATWRWVANDDNCGICRMPFDGCCPDCKLPGDDCPLVWGQCSHCFHMHCIVKWLQSQPVNQQCPMCRQEWKFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZB7</accession>
    <name>A0ABM5JZB7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503279.1">
        <property type="nucleotide sequence ID" value="XM_050647322.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647322.1">
        <property type="protein sequence ID" value="XP_050503279.1"/>
        <property type="gene ID" value="LOC114340088"/>
    </dbReference>
    <dbReference type="GeneID" id="114340088"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd21995">
        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051365">
        <property type="entry name" value="TOX_HMG-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781">
        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF1">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="262"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="262"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="449"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="573" mass="63782" checksum="E6D1CE5C90AC9818" modified="2025-10-08" version="1">MEATYCVGTDVDVCRMFDQYLYKRSENVDLSLSIPQSNFQSNGYDMGDQTFHTPSFGDEEFDIPAINPQQQQQQGHSDQQHYQPPMQGMQQMNQQINQQQDALGMHDPTGGFQQPLYLSGPDHSMVNNSYHSPQPNYPSPQQQQQHNNQLLMIQQQQQQQQHHQQQQQQHHQQMMMSHGQPPPSAMGQYGASPQHPQGRGNSPPAPGQEPTTSDDSDDSTPHPAIITAMKRPSPEPADQTLTKAQKKPKVQKKKKKRDPNEPQKPVSAYALFFRDTQAAIKGQNPNASFGEVSKIVASMWDALDSEHKNVYKKKTEAAKKEYLKALAAYRASLVSKGAGENEGMYSNYPNYQGGAPQQYSSYQPQGTIPSPPMSAPPSATPPAQSPIGKKPPMMGGMPQSPQQGHQGMMQPGMGPVPNHMNMQQHMQQSQQHNSYMQQFIRFSTQVPQQQHVPMSPQQQQPHVSVSPHSHMQQQSPHMQQHMSPPPMVSSSPPVSAPAPSIPTSVSQPNVGQGPGMRPQNACIRHGCPNPAITNPEWEDEYCSNECVVSHCRDVFTDWVSANKNQSQNFSTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1D5</accession>
    <name>A0ABM5K1D5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chymotrypsin inhibitor-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504003.1">
        <property type="nucleotide sequence ID" value="XM_050648046.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648046.1">
        <property type="protein sequence ID" value="XP_050504003.1"/>
        <property type="gene ID" value="LOC126882962"/>
    </dbReference>
    <dbReference type="GeneID" id="126882962"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047318345" description="Chymotrypsin inhibitor-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9342" checksum="3AE8F4A88BE6CFA6" modified="2025-10-08" version="1">MKTVFVAIFMVMVVASVAELIKFGRGDCGENEVEDCEPCCPQEEVTCQNKVAQSCGHPCPLSCVHKCVCAKGYFRNTKSGKCVTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1M6</accession>
    <name>A0ABM5K1M6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carotenoid isomerooxygenase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504093.1">
        <property type="nucleotide sequence ID" value="XM_050648136.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648136.1">
        <property type="protein sequence ID" value="XP_050504093.1"/>
        <property type="gene ID" value="LOC126882988"/>
    </dbReference>
    <dbReference type="GeneID" id="126882988"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65933" checksum="3E93B5AD4027DBA4" modified="2025-10-08" version="1">MNSSDFLNSKEESEKSGSCTPIFSWSPLPQRRNLGCIKQENKDFKSEDKSERLYPNTDATVWLRSCEEEITKPIIGNVTGIIPNWLNGSLIRNGPGSLKVGREEFTHLFDSSALLHRFGIKYGKVEYSCRFVQSEVFKQNWAANRIVKCEFGTKIVEDPCHSIFKRIAAVFQDSSDNSMISVYPFGDELYAFGETPQIHKINPDTLETEDKVAVNDYVSIVHHTSHPHVLNDGTIYNLGLSVRPTGLYHSIVEFQKNENGSGKQMFEEAQIVASISARWQLNPSYMHTFGITENYYILVEQPLSISVPRIFLSKFNNGPLADCFRWYHDEYTRISVISRSTNKIFKTYLAEAFFYLHIINQYEFENHLVLDICMYNDPAMLDCMYVEAMKTMQTNPDYAKMFRGRPGRFVLPLNSNSNTDKTKNLVGIKNTRAKAYYMSDGNIFVKPEKLCDLGCETPRIHYEKYLGKPYKYFYAISSDVDSEIPGTLIKVDVESKTTKTWGEPNCYPSEPIFVPNPEPKSEDDGVVISAMVWGEEDTNHVGLLVLDGESFIELGRAEFHTPSPAPKCLHGWFLPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3A9</accession>
    <name>A0ABM5K3A9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flocculation protein FLO11-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504672.1">
        <property type="nucleotide sequence ID" value="XM_050648715.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648715.1">
        <property type="protein sequence ID" value="XP_050504672.1"/>
        <property type="gene ID" value="LOC126883330"/>
    </dbReference>
    <dbReference type="GeneID" id="126883330"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978880" description="Flocculation protein FLO11-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="31754" checksum="92D6FE1117488D10" modified="2025-10-08" version="1">MKFVLLAVIISVLSYQAIVETKYLPVKSRFERFEPLKQGIALESQSDDNTKNTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSAAPEPQPDDHSKSTSVATEPQPNPTKSTSVATEPQPNPTKSTSAASTTTTSKPDPGHSSSTSQTPTSIQPESTTSSASILEYTQRIFLISVAAFLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K3M7</accession>
    <name>A0ABM5K3M7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_050504793.1">
        <property type="nucleotide sequence ID" value="XM_050648836.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648836.1">
        <property type="protein sequence ID" value="XP_050504793.1"/>
        <property type="gene ID" value="LOC126883365"/>
    </dbReference>
    <dbReference type="GeneID" id="126883365"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="246"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="429" mass="49124" checksum="2C0B36CEB45E6F29" modified="2025-10-08" version="1">MKVSPKSFQNIAKMLDFYSQFNPSPLSIKKFIDFGLNASEKKSFIFLRKEMPVRLANIMKEIALLPENLLRMPSVVAVNDWYMQSFQEIIEFEKKEANAETVEHFCNELVKIRNRHTNVVETMAQGVLELKESHDVDQHTEHSIQYFLDRFYMSRISIRMLINQHIKLFSALLFGGQLENAPGPNSSKYIGCIDTQCDVVSVIKDAYENARFLCDQYYLASPDLIIDISRNNITEEETNTNIVYVPSHLYHMLFELFKNSMRAVMEYYGSVDQYPPITVTISKGKEDLCLKMSDRGGGIARSTTDHLFKYMYSTAPQPSKSDAHTVPLAGYGYGLPISRLYARYFHGDLILLSCEGCGTDAVIYMKALSNEANELLPIFNKTTSKFYRTVVRTNDWSNQCTVIGDRQIATKSKRHELSHSSQESMTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K419</accession>
    <name>A0ABM5K419_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504931.1">
        <property type="nucleotide sequence ID" value="XM_050648974.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648974.1">
        <property type="protein sequence ID" value="XP_050504931.1"/>
        <property type="gene ID" value="LOC126883425"/>
    </dbReference>
    <dbReference type="GeneID" id="126883425"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32005" checksum="01E09F4B1AD9E744" modified="2025-10-08" version="1">MDTQAVLLAPKSNVSSLYYKTKICTHNFCIFNIKNKDGFCYLWNETEGGLSSDNYATIIVKFITEKLLPSIHREPGQDTKIILYSDGCTAQNRNVILANALLNVATLNNVTIQQKYLEVGHTQMEADSMHATIERKLKNKIIHIPAEYAEVCVGARKNPKPYNVSYLTHEFFKSFASLQFYKSIRPGKAIGDAKVTDIRALQYKQGNLYFKLRFTDEWQLLPQRCDKRVSVKPIESLPNLHENRLKISSRKFKDLQQLKSTLPVDYRDYYDNVPHEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4L2</accession>
    <name>A0ABM5K4L2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505128.1">
        <property type="nucleotide sequence ID" value="XM_050649171.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649171.1">
        <property type="protein sequence ID" value="XP_050505128.1"/>
        <property type="gene ID" value="LOC126883530"/>
    </dbReference>
    <dbReference type="GeneID" id="126883530"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="141" mass="15479" checksum="6C96811752DAF660" modified="2025-10-08" version="1">MSRSPLSDTTNTKLGSSFIESVIGQEKEASSGFPTSLIDAATEKKISLTPVVEREISDIYQPIQPEPTLTSFSVELDTAVDKDVSLNSDNFRQDSQSDPPQISDQDSDECMEDTDYIPSDNESDNSDTSEDKFTAADEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K598</accession>
    <name>A0ABM5K598_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505365.1">
        <property type="nucleotide sequence ID" value="XM_050649408.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649408.1">
        <property type="protein sequence ID" value="XP_050505365.1"/>
        <property type="gene ID" value="LOC126883744"/>
    </dbReference>
    <dbReference type="GeneID" id="126883744"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="366" mass="41434" checksum="BC4D7D41B1A2AE8A" modified="2025-10-08" version="1">MEKYFRPDKLEADPNSQTAAKEFKHWYETFKNFLESNKSTEKSLEDKDKHILATRKQQINESIDQYAQQLKLLAKNCNFKAVSSEENKNDYIRDAFINGLVQSNIRQRLLEFSSLSLDEALSKSRSLEDSQKQSDTYHAALNNIASCSHPNSEQTTLASVQTKPGQTCYFCGHPRHPRSVCPARAAICQNCHKIGHWFKMCMQSKKSQTRSTYASTMVIASSMETPQSLSKCIAKVTVNRIDANALIDTGSSDTFLDHEFAIENKLKIFPIQGVQVSMASMSFSANIQGYCLINIQVDKEKYDQTKVLVLSNLCTDVILGQDIMKQHESLEVKFGGPRRPLKICCLTEAKIKPTLLLQLFNLVPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7G0</accession>
    <name>A0ABM5K7G0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Disheveled-associated activator of morphogenesis 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506128.1">
        <property type="nucleotide sequence ID" value="XM_050650171.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506130.1">
        <property type="nucleotide sequence ID" value="XM_050650173.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650171.1">
        <property type="protein sequence ID" value="XP_050506128.1"/>
        <property type="gene ID" value="LOC114334644"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650173.1">
        <property type="protein sequence ID" value="XP_050506130.1"/>
        <property type="gene ID" value="LOC114334644"/>
    </dbReference>
    <dbReference type="GeneID" id="114334644"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="84"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="647"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="928"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1141" mass="129865" checksum="A093EBDD4C94BA7B" modified="2025-10-08" version="1">MCSKVQISELMDKLHSGLPKCSLKIPAWDNISNALPRLHIPAMPAVRSKRGWCGCLQDDEPPEITYCVVENTGTLTLQAITPTQPMPSQEELDVKFAELVEELDLTAPNKAAMMSLPPQKKWQIYCSRKGEDTEDQTHAPEHYVERLRTLATLEYPETNTEEEVRSRTKQIDGLKTALRTSTHSFVIKFIELDGLVATLECLERMDYFTAQSSIHTSIIGCVKALMNNSTGRAHVLAHPTSINTIAQSLSTENIKTKIAALEILGAVCLVSGGHKKVLDAMLHYQKYAFERTRFQGIVNDLDRSTGVYRDEVNLKTAIMSFVNAVLNYGQGQENLEFRLHLRYEFLMLGIQPIIDKLRGHENETLNRHLDFFEIVRNEDEKELARKFEQEHVDTKSATSMFEIIRKKLSHTAAYPHLLSLLEHCLLLPLDYGSYPQHWLLFDRIVQQIVLQQTEEAKTVKNPDVCPIDINVKEIVHLLAKEEELVAARKKAGELEKENVDMSNKLAKKEQELDHRTQEKEDLETSLSRIKERLEKETSSHIETRQRLSELEYKAADLDRQVLSERGERHRLELLVNSGSIPDDAKAISLNKALEPSTVECKNEFISSIPPPPPLAPPPPPPGPPGPPPPPCAPMAPPAEPLKIEIQKKNIPQPSNPLKSFNWSKLPDAKLNGTIWSELDDSKLYNTMELDNIDKLFCAYQKNGVTNDGSIEDLRQLGKNRTKILSVIDSRRAQNCTILLSKLKMSDEDITKAILSMDSKEQLPMDMVEQLLKFTPSSEEAALLEEHSDEIDSLARADRFLYEISKVPHYEQRLRSLHYKKRFQVTLNEILPRITGVMEASREVSRSRRLRKLLEIVLALGNYMNRGARGNASGFRLASLNRLSDTKSSAAKGTTLLHYLVQVLEKKFKDILRLDEDLPHVREAAKVSLGELNKDMAQLRAGLKDVAREIEFHRSQSPLANDKFVPVMREFQATATCRLAEIEDQYQDMKNRFDRAVRLFGEDPSNTQPDEFFGIFDTFLNAFIEARQDNENMRRRQEEEEKRAKQEADLKKLTLERKHSREGILTSINKSLSLKRGEKNGDKGEFDDLISALRTGDVYGEDIAKFKRSRKSRVGTGNSPPRRNSTTREDSRERIVTTGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7R1</accession>
    <name>A0ABM5K7R1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PiggyBac transposable element-derived protein 4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506218.1">
        <property type="nucleotide sequence ID" value="XM_050650261.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650261.1">
        <property type="protein sequence ID" value="XP_050506218.1"/>
        <property type="gene ID" value="LOC126884322"/>
    </dbReference>
    <dbReference type="GeneID" id="126884322"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032718">
        <property type="entry name" value="PGBD4_Znf_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13842">
        <property type="entry name" value="zf-Tnp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="177"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein 4 C-terminal zinc-finger" evidence="2">
        <location>
            <begin position="587"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="73614" checksum="D51BB631236B962C" modified="2025-10-08" version="1">MASAKNIDGARFNTSYWIPAPPVGYIEQCNVPSQAVRKVNKMACSSNTSRKRKREKTKVSMCGLAEADIDRILDCLDSDEDPYIDSGSEFQPTDSEASSEEEIDHMLCTENHSDSEDEINEMAANDEQKEAQAVRNALPENFSVNWTKGKFIPQIHNFDDKTAGACLENTEVPFSELDYFLLFMNDEVVNMIITQTNKYALEQTHLNTKITWTAMTKEDFFTFIAVLFLAARHRKNKLVENWSTDELLYTPIFGKVMSRNRFQIILRMLHFADNAQQIKGDSFHKLRGIFEKMKNTFAQRFSPFQNLVIDESLMLFKGRLLFKQFIRTKRHRFGIKLFLLCDCETGYVLNFIVYTGSKTEIELYKDLGISGSVVTTLMKSYLDKGHSLFTDNWYTSPTLSTYLFEHKTNTCGTVRTNRKQMPDLSGKLEKGETKSMVSDNMLAVRWKDRRDVNMLTTFHKDQMINVNKTNMKTGESVKKPECVVHYNQNMGAVDRTDMMLSSTECVRKTLKWYKKLFFHILDLCVLNSHALFLMQNPGQLPLADFQLRLTRQLLESYNVPKTIPRTLNTSKHQRLTGRHFPAMVPNKKVRRCIVCSQSKIRDQKKRRDSRYMCNECDVGLCVFPCFEEYHTKEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8Q6</accession>
    <name>A0ABM5K8Q6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506573.1">
        <property type="nucleotide sequence ID" value="XM_050650616.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650616.1">
        <property type="protein sequence ID" value="XP_050506573.1"/>
        <property type="gene ID" value="LOC114334984"/>
    </dbReference>
    <dbReference type="GeneID" id="114334984"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="684" mass="78511" checksum="750446086DB3C1CF" modified="2025-10-08" version="1">MAEQTEDFNDGEESRDHEEIDYVSPEIIYLEDNGDNTELKGFTHLGPLVEYIYDETAIVEYNDHQYTELDYATQDNSEHIIQDVCSTEINDDSSDLIQPMMPFFLSSQVFATGEEQDPNDGETIILQVENEEEEVVEQRKPIPDEVKSSTLQLLLCSSKTNSVLDTYICEVCSICYGCLNCLKSHYETMHLGNTFIAHYKCKYSTHISKGLCCPVCELTFNTKSETMDHYITHAVACDICGSGFDRQQYLSEHRRKVHNKGDFDVIYDCEICRGNFQYPSGLSKHYQEVNDLLLRLNNTREFTPPLENTQTQYGMNGKVIHSLLNFIKNEYNFTERQNYLNSVPQFITNIQGINVHFIHVKSKRPANVPVVPILMLHGWPSSVNEFYKSIPKLTSKEYQDKFAIELVIPSLIGFGYSDGASKPGFSFVHSANIMRLLMNRLGYKKFLVHGSDWGAFTVTALATLYPDSVIALHSNFCSSLRTVTLFKTLLGSIWPRGFVDDKYEENIYPFLNQLRFIFYESAYFHLFGTKPDTIGHILDSSPLALITYSFEKLSVGTNRTNVFSSTAGLEQLDLTTFIDSILFYYWFPQKSTTAARYYCENITLKGFKFGLHNIPIDKKIPCACAYFENEFIYQPEGFLRDKYPNIIQYNTYPSIGHFAAIQNNKILTEDIMSFVIKLYDSKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8X9</accession>
    <name>A0ABM5K8X9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase greatwall</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Microtubule-associated serine/threonine-protein kinase-like</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050506647.1">
        <property type="nucleotide sequence ID" value="XM_050650690.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650690.1">
        <property type="protein sequence ID" value="XP_050506647.1"/>
        <property type="gene ID" value="LOC126884630"/>
    </dbReference>
    <dbReference type="GeneID" id="126884630"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05610">
        <property type="entry name" value="STKc_MASTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037638">
        <property type="entry name" value="MASTL_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="519"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="561" mass="63572" checksum="50E14F865F2DA587" modified="2025-10-08" version="1">MTTEPDKIKCTEKIKNTKIPEINDFVILKPISRGAFGKVFLGYKKNNTDVMYAIKVMKKTEMINKNMVTQVQNERNALALTKSPFCVQLFYSLQTATSIYLVMEYMVGGDLKSLLSVYSFFDESTAIFYIAEVCLALKYLHKHNIIHRDIKPDNMLLSKEGHVKLTDFGLSKVYIDRDLEISDFENFTPNVCKRTPGQLLSLMSHFSFGSANSKNINSAAMCSDSFIDMQCESAISKHEISHVKENISNNVTNSSALSGITFLSVDCNNTHQDTSYYTFQSSQECTGNNSSSHSPVSRKAYTKYKLKDINERKRKMSSPSPKLSRKAFLRTGLTGDMEMIRLDSPKGVTFSTPVSAQKCKKKPTTFEVPKNMVAESIKLTDDNIQIMSPIAATFATPKTARTPFRTPKSIKRLQWSVNQRILGTPDYLAPELLLQKHHDYAVDWWALGCCFYEFVTGIPPFHDLTPQLIFKNILENNLEWPTDDEALSDSVVHSIECFLTSDPEKRATGEDMVTMDAFKDIDWDNLLTTVPPFIPEPYDVTDTGYFQARNELLKFNISNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9E7</accession>
    <name>A0ABM5K9E7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dystrophin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506812.1">
        <property type="nucleotide sequence ID" value="XM_050650855.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650855.1">
        <property type="protein sequence ID" value="XP_050506812.1"/>
        <property type="gene ID" value="LOC126884726"/>
    </dbReference>
    <dbReference type="GeneID" id="126884726"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16242">
        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="16">
        <location>
            <begin position="683"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="927"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="283"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="931"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="109706" checksum="9C94F9B502B222AE" modified="2025-10-08" version="1">MHKKEENFDQKKLDLEVWLQKMESRLAGMAPVGHTADVLEVQLREQKGLHAELHQFKSQIENFQHLTQRLITAHQHEDTSRYKKAAEYINQHYLRLDACIINRGKLLHSALSSLQNLDRSLDKFLGWLSEAESVVETLEGDNESRRATLQLKELQADIELQAQTHHALRNSSLALLGTLAAEDALMLQLRGDEMERRWQALCTRTSDLRNRLEHNADYWNALLLSLRELTEWVIRKDTELGLAARQDDHRAFRQQLEDKRPLVESSLRSARQFVAGDPAGELARNLRRELVKLSDKWNALIDKSDQLAARFEQNSIKLKQLTISLEEASSAVSRLERATLTWSGPRSAAEARELLSNLRTLEQQLPSLQRTLEEARIQAANIVFNAGNGLPNNLAAQLEDCSARCRALQAAIRERRDQLTSSTQGEISPGPSSVQPPWERAITPNKVPYYINHSTETTHWDHPQMLDLAACLLQLNEVRFSAYRTALKLRAIQKKLCLDLVSISGASEAFDLHGLRAQNDKILDVADMVLVLRAIFGNIIANETVQIDVPLCVDLALNWLLNVYDSQRTGQIRVLSFKVGLTLLSKGHLEDKYRYLFRLIADPQQKADQRKLGLLLHDILQVPRQLGEVAAFGGSNIEPSVRSCLGEREDLEATHFLTWLKQEPQSLVWLPVLHRLAAAENAKHQAKCNSCKQYPIVGLRYRCLKCFNFDMCQSCFFSGRLTKGHKLNHPMHEYCAATTSVEDVRDFTKALKNKFKSKRYFTKHPRMGYLPVRSVLEGDELESPVASPQHNDMHSRLEIYASRLAEVELRAASPEDEHRLIADYCHSLEGAPASPGQLMLVIDEEQRAELQEMIRELEVENQALLQEYDQLQRGSNPIPQPQPQHDVLAEARLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEPGPTSTLQTRSVTASQLNQDTPGRINQPPPPADHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAL7</accession>
    <name>A0ABM5KAL7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GTP-binding protein Rhes</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507230.1">
        <property type="nucleotide sequence ID" value="XM_050651273.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507231.1">
        <property type="nucleotide sequence ID" value="XM_050651274.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507232.1">
        <property type="nucleotide sequence ID" value="XM_050651275.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651273.1">
        <property type="protein sequence ID" value="XP_050507230.1"/>
        <property type="gene ID" value="LOC114338119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651274.1">
        <property type="protein sequence ID" value="XP_050507231.1"/>
        <property type="gene ID" value="LOC114338119"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651275.1">
        <property type="protein sequence ID" value="XP_050507232.1"/>
        <property type="gene ID" value="LOC114338119"/>
    </dbReference>
    <dbReference type="GeneID" id="114338119"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37057" checksum="9981327A3D4B21B0" modified="2025-10-08" version="1">MDLSACRSCFCHNSQPNEESMVSQECQNIVVSYPGPSSANNNSSGDDAVAPFKNCYRLVVLGSSRVGKTCLVARFLGHKYTDGYTPTIEDFHRKIYRIRGEIYQLDILDTSGFHPFPAMRRLSFLTGDIFVIVFSMDSRESFEEAARLREQILETKVNALASTGGGVGITRKKTLPRVPMVFAGNKCDRDMKTVTVEEAQAYCDSQDASCTFVETSAKKNFRVEEVFYQLFLVAHLPLEMAPNHHKRVSASFGSPSPLPPPTPVHQSKKYHLSVKRKLSDALGVVTPNARRPSIRTDLMIMRNKTSRRGDTSGASNNNSKWWKKSGDVCNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAS9</accession>
    <name>A0ABM5KAS9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507296.1">
        <property type="nucleotide sequence ID" value="XM_050651339.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651339.1">
        <property type="protein sequence ID" value="XP_050507296.1"/>
        <property type="gene ID" value="LOC126884960"/>
    </dbReference>
    <dbReference type="GeneID" id="126884960"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="178"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="405" mass="46115" checksum="5CF961F52EB9DB23" modified="2025-10-08" version="1">MKTKSAFTVHPNYRCGEISDVASKENEKDFTVIKGSEINPSEGDEEQRPDSGGFRSCVCFIVIPIILLVNSVTETELLEMSGGSTDSEVLGEMKEKNKVRNTKKVTSQQNFETLFASSSSKFCSFQPIIPEETPEPVVESENIILETNFSDEAIISPEAIANAQFLNVIEQDDDNIQFEFHAVSTSQELSQLEENLKDPNYEKKVRNYFKKIIGNIPDTSNGLDTCYSIVDYFFEKKFMVQCSWTGGSRSNTEKCCIKNCKNILEVFFTIVQSSNKDFSKALLKKFIIGIRRNAKKRSLTGGIRQSSIHRRKKSMVKKQRLSGNRKGVAQRQGKGTYIKKMYNIKIIISGENEIFNENEQSFNEEKEYDEDNDEYGMEEYEADGEDAIIEHDEVEEEDNNDTDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBD6</accession>
    <name>A0ABM5KBD6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507503.1">
        <property type="nucleotide sequence ID" value="XM_050651546.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651546.1">
        <property type="protein sequence ID" value="XP_050507503.1"/>
        <property type="gene ID" value="LOC126885116"/>
    </dbReference>
    <dbReference type="GeneID" id="126885116"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046297693" evidence="1">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="336" mass="36050" checksum="5CF493696BB02D8D" modified="2025-10-08" version="1">MKVLVCALFLSVLVYGEETKKSDKRGVPEGNVVSLDSLGSGINLRSLGSPLSLSPYVGSPSLGLPLNLRSVSGYSPSIYGSPLSAHSVGHSVGSPSLGLPLNLRSLSGYSPSIYGSPLSAHSVGVQGLDLRSLASVLNVGPSTHTVNTITKHFPFAVPQPYAVPVDRQVPVPVPHPVPVAVDRPYEVKVPQPYPVTVDKHVPYTVERPVPVEVKVPVRVEVPVPVKVGVPQPYTVEVPKPVAVPVPSPVVVKEHVPVPSPVVVKEQVPVPSPVVVKEQVPVPSPVVVNEHVPVQQPIYVREQVNVPQPYLLKEHVPVESPVSFRQHNVHHQNPYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBT7</accession>
    <name>A0ABM5KBT7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507657.1">
        <property type="nucleotide sequence ID" value="XM_050651700.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651700.1">
        <property type="protein sequence ID" value="XP_050507657.1"/>
        <property type="gene ID" value="LOC126885236"/>
    </dbReference>
    <dbReference type="GeneID" id="126885236"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52131" checksum="A2CCA58A9F287D1E" modified="2025-10-08" version="1">MCAFKAEHLLVDELDYELKIRDIMPEESTTVGKKRNLLRGALKQEAGNRSFLQISAVSIPFEEQQKGISETLDSLSKKIEKFRGTVKDTEYARLTSRLGHISARVHLLHCPTEEQEPFKKSVSLRILTLEGELDSRVNPIATSTPNAPVNVSSFTYSKPVQVHKWGISFSGEKQHTDVMSFLERVECLRVSRGVSEEDLFAASAELFTGTAFTWFRNNRGNFSCWSDLIKKLKSDFLPYSFQDDLLDQIKNHKQKPGESVTMFINTILGMCSRLDTPLSDLAKIKIILKCLLPFYHQQLALMDIQNIDDLTIKCKRLEETLSWSSQPPSTSRSYSNSSSQPTSFRQRSWPNKGHDHNVSVVSSLVCWNCDQPGHPFYNCAIPQSRIFCHGCGRENTLKRNCSKCSGNETSEVRPLNVSPSNTQSGNPTPSSNETAGPSTSSNPNPSSRKGKGVSFKKTAHTTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC71</accession>
    <name>A0ABM5KC71_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507780.1">
        <property type="nucleotide sequence ID" value="XM_050651823.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651823.1">
        <property type="protein sequence ID" value="XP_050507780.1"/>
        <property type="gene ID" value="LOC126885304"/>
    </dbReference>
    <dbReference type="GeneID" id="126885304"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="613" mass="72659" checksum="BE4EF74144AB9D03" modified="2025-10-08" version="1">MSLPQEQNQPFSKEQCESKNKMGKDNISLIDGITDVKIKIEEDMEIPYNYSMQLNTSVNSEDFKIGHTESSDQVKSESPEIKQEYKEAGFALDKIKYVDPSNNQSDGFRITKESIKVEIKQEYEQCDLFPEELNIHNAHLNSEVKLEDFVKLEKLPKRKIKPTNRRKKLKDYSYFTRKWCSWLNLRKNRNRIHSCSLCGQTCIKPSILMFHYKVYHCTKKETQKKTQNKSSSMLHGLVKKENDQMLTNGSSYEGNYIFDTSEKPNSEEVNLKNFINTNQLNSYFSNGKKVFECHVCFKSFLRISHLTRHQRVHSEQKPFQCEICGSRFKKEDQMTMHQKVTHLGIRRYKCLVCLKQFAYPSTLKEHMLLHTGETYKCDICSKEFTTKKYLEYHIFGHNKEKPFKCEVCPKEFNFKKLLKRHMFVHAEEKPFACEVCPKKFSSKGSLWQHRLLHAEKRFKCSVCLKEFATSGNYKQHFLKYSEHRLLQCEFCSKNFVGKSEMKRHLQTHTRDKRLQCEVCFKRFSVISTFKTHMILHEDEDRFKCDVCQKKMTSQRGLKGHMRIHTGEKPYECNICFRPFTNHSSMMTHRKIHTDKIMIPSVQKKAANFMELYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEB8</accession>
    <name>A0ABM5KEB8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508546.1">
        <property type="nucleotide sequence ID" value="XM_050652589.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652589.1">
        <property type="protein sequence ID" value="XP_050508546.1"/>
        <property type="gene ID" value="LOC114331507"/>
    </dbReference>
    <dbReference type="GeneID" id="114331507"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045664667" description="Cuticle protein-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="57221" checksum="65B3A98A3F5EDC16" modified="2025-10-08" version="1">MAAKFLVLAAFVVVASGYEHHDENFGHGAQHAISTYSTVQHHAPAVHAYAAHVPAVQTYAAQPLVQQYAAPVVHAYAAPVAKTVYAEPSAPAHYDFAYGVADPHTGDSKHQHESRRGDFVHGSYSLLESDGTKRVVDYTADPHHGFNAVVHNEPAVHAVAPVVAKAIVPNVAYSAPVHQAYAAPVAHTTYSVPTHAYAAPVAHAAYAAPLAQTYSTSVAHGYAAPLGHAKAGHYGYAAQAPVVSYNVYYCEVYDLTSIMTAKFIVLAAFIAVASAGSWGSGLGYSAPALVGHGSHDAISTYSTVQQHAPAVHSYAAHAPLVHAPVAHSYTAPVAHAYAAPVGHAHAEPSAPAHYDFAYGVSDPHTGDAKSQHESRRGDVVHGSYSLLESDGTKRTVDYTADPHNGFNAVVHKEPTVHAVAPVVAKVAAPVVAKIAAPVTYAAPVAHAAYSAPAVHAAYAAPVAHASYAAPVAHNSYGAPVAHAAYAVPVAHAAYAAPVAHASYAAPSVHEYGTSVAHGYAAPLAHGHHGYAAPLAHGHHGYAAHAPVLAHNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEC6</accession>
    <name>A0ABM5KEC6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 SUMO-protein ligase KIAA1586-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508544.1">
        <property type="nucleotide sequence ID" value="XM_050652587.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652587.1">
        <property type="protein sequence ID" value="XP_050508544.1"/>
        <property type="gene ID" value="LOC126885833"/>
    </dbReference>
    <dbReference type="GeneID" id="126885833"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34952" checksum="186957291150A178" modified="2025-10-08" version="1">MLVVLERAQQQTSLRKKIFDHKVSDAHEAAVGIFADSQKETLEKVFLKTVSKEKEAEIAVQELNGLDMGRILHSRNACANIITHISSEMEKQNVQEIVEGTDRFALIIDESTTLSKKSTLILYLRVCLKKLNKESPVHLFLDLVELENVTSRGIFNAVMKWLEGHKIDENVLKSRLVALACDGVAVMLGGKSGIGVLLKEKFPSIVICHFCNHRLELCVSDVVKKIASINRFKGFIDKLYVLYHASPKNSRELHVCADELGVQLLKIGRVLNTRWVASSFRTVSAVWENYEVLANHFAAAKVDQTCDPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFI9</accession>
    <name>A0ABM5KFI9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050508966.1">
        <property type="nucleotide sequence ID" value="XM_050653009.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653009.1">
        <property type="protein sequence ID" value="XP_050508966.1"/>
        <property type="gene ID" value="LOC126886158"/>
    </dbReference>
    <dbReference type="GeneID" id="126886158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047394087" description="non-specific serine/threonine protein kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="10">
        <location>
            <begin position="130"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25060" checksum="B820F751B7A26A8C" modified="2025-10-08" version="1">MLIVILADLLIIVIFLVPTKKISSDSTPISTPDRKIPAANSDTPCSARRVLGSIERSIQKVVHVLTPRKIEDSFSICPAVLTNKELFNVSTTQCSDPEFVIAELTKALEKKGVLCKRKGFILRGKLESCPKQNLGECSFELHICYLPDLSVHPHQSTSTTPTKSILKKAISSTPLNTRRNKENQTTGFVGIRRKRLRGDSWCYKKVCEEVLALTSKEFAAFSESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFY6</accession>
    <name>A0ABM5KFY6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509112.1">
        <property type="nucleotide sequence ID" value="XM_050653155.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653155.1">
        <property type="protein sequence ID" value="XP_050509112.1"/>
        <property type="gene ID" value="LOC126886284"/>
    </dbReference>
    <dbReference type="GeneID" id="126886284"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="350" mass="41128" checksum="197A7457EE214357" modified="2025-10-08" version="1">MKGNDGFYTNDYENVPDEMKFKSKKKLKDKILVWCAISEAGFISQPYIGVVRGEALNANIYIQRYLSKLVQFVNTHHANDQIVFWPDLASCHYARITRDWYETNNITFVPKADNPPNLPQARPVEEFWAILSRKVYNNGWEAQKQEQLRRRIYTKIREIDAEVVQRMMQRVRGIIRQIENNGLSYKKNRREMMKMLPEDSFSINQISLESEEVTINNSICSKDLNYKNNVNEPMSIETGEGREKNKCEICFKQFSTSSSLKRHFIVHTGEKHHKQFSQLNSLKEHLMRHTGERPYKCDVCFKSFTRAPELKKHMSAHTGEKPHKCEICSRQFSQKVHLKTHLRLHTGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGD5</accession>
    <name>A0ABM5KGD5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509245.1">
        <property type="nucleotide sequence ID" value="XM_050653288.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653288.1">
        <property type="protein sequence ID" value="XP_050509245.1"/>
        <property type="gene ID" value="LOC126886382"/>
    </dbReference>
    <dbReference type="GeneID" id="126886382"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="75"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="517" mass="57443" checksum="8331AAACA0D3F07D" modified="2025-10-08" version="1">MRTSYARVQGFNRPAVKEFFDLLEVEYTRKNYSPDRVYNVDETGLTIVQSKVPQVIGRKGKRQIGALTAAERGSLVTLVCAMSAGGTFIAPMLIFPRKNFSDVLMKGALPGAIGRVHPSGWIETNLFSEWFNHFVSKTNPTEDSPLLLILDGHYSHTRNIAVLEVAREKHVTIISLPPHTTHKLQPLDKTFMSPLKSHYSEEIRKFLLHSDRMVKPHDVAELFGKAYLKCATAEIAVNGFKVTGIYPFNPQIFKDADFLAASQSLQLEEENISSSSTTLMMNPTESSVETATLTIESSRQPTSCTVPESSIQLKSCAPSTSTSDSVSLQPKSSSEHGRLLTIKPSVFYSKPGTSSAVNPSLILPYQISPIPKPKIKTSNRGRKSTKATVITSSPYKFELEQSLKKTEDRKQSCGRGRGRGRGRICKKAQEKVRKRITVEDSDTEESDLSNIEEDTDSELSSQGSIPDNDDAVCIFCEESYSSNSRGETWIKCQSCLLWAHNECAGAETEHYMCDFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHA1</accession>
    <name>A0ABM5KHA1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509574.1">
        <property type="nucleotide sequence ID" value="XM_050653617.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653617.1">
        <property type="protein sequence ID" value="XP_050509574.1"/>
        <property type="gene ID" value="LOC126886625"/>
    </dbReference>
    <dbReference type="GeneID" id="126886625"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046728015" evidence="1">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="112" mass="12899" checksum="C43A46AA5C58EE6A" modified="2025-10-08" version="1">MKSIFLLVSLAVVSARVPLVPEDHRVNHAVNHWIKPSLPLGIQPYECFLPVNIPPCIGDARAIPVYRWDFWTNRCVRDFYKTSCIPSRNKFATLKQCRFEAEPVCKLVVTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KJI4</accession>
    <name>A0ABM5KJI4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510369.1">
        <property type="nucleotide sequence ID" value="XM_050654412.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654412.1">
        <property type="protein sequence ID" value="XP_050510369.1"/>
        <property type="gene ID" value="LOC126887076"/>
    </dbReference>
    <dbReference type="GeneID" id="126887076"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="339" mass="39580" checksum="CB68F28E80A774E2" modified="2025-10-08" version="1">MSQTKFYELLRMLPFSKKYTPFREPVSWEERLALTLKFIGHVNSFTTLSFSYRLGYTTVRTIVYETLECIWENLQPVVLPNPSKEHWEKIERDFHEMWNFPNCCGALDGKHVVIEKPPRSGSLYFNYKHQHSIVLLALVDATYRFVTVDVGAYGRNSDGGIFNSSSLGKKLYSNELNFPPSKPLPNTNTVLPFVIVADAAFPLKDNIMRPYPSNEIANNEAYKVYDYRHSRARRVVENAFGLLTKKFKWYSTKYNILPRNIDKIILATVVLHNFLRNDKCSWQPEELEKEDFCFLRDLSHIGGRTPFSAERIREAFTEYFVSPNGSVPWQLERVYDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KP70</accession>
    <name>A0ABM5KP70_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511992.1">
        <property type="nucleotide sequence ID" value="XM_050656035.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656035.1">
        <property type="protein sequence ID" value="XP_050511992.1"/>
        <property type="gene ID" value="LOC126888030"/>
    </dbReference>
    <dbReference type="GeneID" id="126888030"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25563" checksum="C61082069FB1BE51" modified="2025-10-08" version="1">MHHPNTPPPQPQGVTPSCRKGAWPRGNIVGYKQCLREMTEHGLSGTKEHFPTGPISTAKLVRRTMGRKNKNNKGGRAHRERKRNLKRGEKERDETRGEKSWRREVEEKERKTEKRENREGIEKQQTKRGRKKENRKRKEGEENRQRDGKNKTKDILRKENMKEEERKAGSSDSGSSSDDEWQKHRSRKTRQENRNEQLGGRGTHTQLQYQIKVETPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPD1</accession>
    <name>A0ABM5KPD1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Atrial natriuretic peptide-converting enzyme</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512037.1">
        <property type="nucleotide sequence ID" value="XM_050656080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512038.1">
        <property type="nucleotide sequence ID" value="XM_050656081.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656080.1">
        <property type="protein sequence ID" value="XP_050512037.1"/>
        <property type="gene ID" value="LOC126888063"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656081.1">
        <property type="protein sequence ID" value="XP_050512038.1"/>
        <property type="gene ID" value="LOC126888063"/>
    </dbReference>
    <dbReference type="GeneID" id="126888063"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF146">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="11">
        <location>
            <begin position="90"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="12">
        <location>
            <begin position="232"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="546"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="88669" checksum="BFD2D9E6235D8353" modified="2025-10-08" version="1">MTVSMERKGHRKSSWDSKTSVSSIGSGSRHYRRSPSSIISSDSDIRFTRKKLTSQYKCGCCIIAIFLLFLLLAAVGVYLGYTFFLPQDPDEQIFRATFRVIEGDTFSSELADPSTNKFRNRSRDYRERLNLLFRRSSVRHGYMGTEVLALDGTEDKDLVVHFNIHINPYYLEIRAKDLENILSNEISLAESLFFKNLTIDVKSVEVKPENEPPRVSSTTVISVTEAITEKPEPPRRCFPLELDYCKKLGYNITTYPNIFRHWSIKDVKNDVISFRELVDAECYRHAYDFICQILQPSCKKGTTEDEMILPCRSFCRDFMTGCGNRLQGKIKEFLDCARFPEFGDGTCFSKPGCVEELQSKALSPRICDGVIDCQDVADEKSCSYCPKSHLHCGIGRVCIQKSKRCDGHWDCPDGSDERGCLSLAPTVESMKKADMVTPHPLRYYSEGFLTFNEKGEVGKLCTESINKSLPLNQSIAVLAAAATSLCKTLTYENMASMKIEYDFEENVPYVRMRNPTASEISFVRTKCPSKQVLKVTCSDLQCGISATHGQNGLKTLSKMAQHGDWPWHTTLFKEDVHICDGTLVSPDWVATTTSCFQGQPKAEWTARFGITRLFSSTPWEQERRIIGMIKSPVEGSTIALIKLDKPVTLNDFVRPVCLPKENMGLPSEQLQCNTLGWTRNREQLQRVQVKLADKEKCENISISSVNSICTEAFYGENDCNEEEFAGSPMICQYKKDERWFLTGITNWRIACAKNGSERPRLYDKISSNVKWIKDSMNNDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQR5</accession>
    <name>A0ABM5KQR5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497151.1">
        <property type="nucleotide sequence ID" value="XM_050641194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512529.1">
        <property type="nucleotide sequence ID" value="XM_050656572.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512530.1">
        <property type="nucleotide sequence ID" value="XM_050656573.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641194.1">
        <property type="protein sequence ID" value="XP_050497151.1"/>
        <property type="gene ID" value="LOC126878458"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656572.1">
        <property type="protein sequence ID" value="XP_050512529.1"/>
        <property type="gene ID" value="LOC126888375"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656573.1">
        <property type="protein sequence ID" value="XP_050512530.1"/>
        <property type="gene ID" value="LOC126888376"/>
    </dbReference>
    <dbReference type="GeneID" id="126878458"/>
    <dbReference type="GeneID" id="126888375"/>
    <dbReference type="GeneID" id="126888376"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="226" mass="25561" checksum="1E65C047436730E7" modified="2025-10-08" version="1">MENSYPVGLLNKLIFSTATSPASITLIDNTNNKKPPTVNMASQERNTSPTIDTLVPTTPQTFGSLPYIPFLTPKLLKLFKGLENIKIATRNVKTIAHLYTKTKDPLTTKESSKVVYQIPCSDCDKVYIGETSRTLHSRIISHRSDINTKKSQACALADHSINLNHTFNFSQASILERVKNEQKRLFVEMTHIQKNRKCINRKSDIDKLSNIYCYILAHQQTFDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSI6</accession>
    <name>A0ABM5KSI6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513157.1">
        <property type="nucleotide sequence ID" value="XM_050657200.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657200.1">
        <property type="protein sequence ID" value="XP_050513157.1"/>
        <property type="gene ID" value="LOC114340067"/>
    </dbReference>
    <dbReference type="GeneID" id="114340067"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39072:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39072">
        <property type="entry name" value="RE48511P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="3090"/>
            <end position="3115"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="7">
        <location>
            <begin position="2880"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="3000"/>
            <end position="3038"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="3050"/>
            <end position="3085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1617"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1670"/>
            <end position="1693"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1707"/>
            <end position="1759"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2173"/>
            <end position="2222"/>
        </location>
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            <begin position="2338"/>
            <end position="2357"/>
        </location>
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            <begin position="2442"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="2552"/>
            <end position="2578"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3148"/>
            <end position="3198"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="3259"/>
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    </feature>
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        <location>
            <begin position="3393"/>
            <end position="3416"/>
        </location>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="127"/>
            <end position="151"/>
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            <begin position="152"/>
            <end position="161"/>
        </location>
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        <location>
            <begin position="162"/>
            <end position="197"/>
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        <location>
            <begin position="316"/>
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            <begin position="950"/>
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        <location>
            <begin position="963"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="2193"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2342"/>
            <end position="2355"/>
        </location>
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        <location>
            <begin position="2465"/>
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        <location>
            <begin position="2480"/>
            <end position="2491"/>
        </location>
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        <location>
            <begin position="2527"/>
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        </location>
    </feature>
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        <location>
            <begin position="2562"/>
            <end position="2577"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3170"/>
            <end position="3180"/>
        </location>
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        <location>
            <begin position="3075"/>
            <end position="3084"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="3442" mass="387626" checksum="9AF5B2327794CE48" modified="2025-10-08" version="1">MPKVIASLNKGGIQQNSQTHRYKRQVTQLGSNNSSKKKRRVVKKLTRVQLVSNGTLDDSDNQNLEGDVKKINQEATTKRKLRRIKIKKKKLRQNIVVQDDQHLQEATKPRKRIVVTKKRLLTRNKYSDSVSYSETDTPLSSTKTYPYQNINEHTRGNHEYENTSEENEIDDYSDDDDDDSEENEDDEYDDDREEDENHLDYRPKYLDDEDYGDDTTEQNEIVTLKESDFFYTNFEDEPITTADLIPPTEVYTENPTIFTNASTATESVKNELTTEKEVTTEEEKGTTLINSEQDKDVTTERQNLPIEITSETDKGSSVSTTSDVSSTEATSKRNLEDITEEIEDINDTPTFQNIPEYEPYFPELIESLDAPIVLFKTTVLSSIELLTKTVVQSRLRTYTYVITTKAGDEQVVTSTTEVKPHTKTTVTTESITRLKTLTLLDIDPTSTLTSPQQPISSVLDKSQSVQDNQVRNYDEARNLATRIMSNGVEVIVAGDKTIPGDKDYKRLLTSGTYKGVTLKPSTLRENMLMMLPQDSSNIDSLTSSLYPNQFITKTCLTTFTYLTTFLEGSTTTVSSHEQVVSNIATEERNTGKILPTPAVGVTLTQNPNLSVGVFHTTYTYLNTILDGDQPLVVSSKHTVTNTITAPDDYLSLLKVSGTLSPMKDTNTYYSTIGLEKTLYEGNKTSVMSTKEVVTQVVITESVPPRATSVMTSYIALDFKDSPDASFVTTDVVKTYFVTYTYFNTINENNVPTVFTNISVSSDVVTEKLYIIPKTSNKFDFQSKEQRLENNFQIYTTKSYLTTFTYFTTLLQEENQENPTVINSRTSVVENLVSETVDLSLLDKSNLNEIRNAIEQGLKSLVQTITLYNGETFEITAVANDKNKADERINPTKVLPIEKTQMPETFSLIKDDNLQPESSPSIITGSTIVFIDDDPFAQLAPTPVLKKTTEIKTNASPSTIKPSKGLKKSKRSTKSKTKVQTTSISPSKSKKHNTETYKAKPQTEEKNKDKKNTPAKTGKPIQENDLLGLGSINMDSLQAFAPFLNSMAGFISTNLKANRRNDVNVTTTTTKVDTNKITKFKTNQPIKDQETEADTSKEDAQDVQSRSPIYIPVRGLDDEFEIAESQNIASFDWVDPPLTNKKIQEYHAHESALISHGIPISPGDIITTNSDVIVGKPGRVGPRIPSIPVQQVSQENEIPIGMKPPPPGEHWKKNNHEYKRIPVTNNFEKPSEYRHEDYLGPPPPIAPFEYNAQNDKVNEISGNPVYAKNQKNYEPVYPQQHYNDQQYKFKDQQLPAFTHNHPVYAQTFNHEPPTREKPFNPNTKPVYSLQEPVPPKQHSNNRPLYVPADYHDIPINQGEILTGAIPHVQIKQYDPPDHLHVNINNQQHVNIEPHHHEIPIKQYNAQEHMHININNQQHVNIEPHHHEIPIKLQEEILTGGKLNNINVKPSIINNEHFILPEVIERSTGQPLLVNIQPSQVAFVNIPYNRTTALIYGGSTEPHRNGQYFDDPSPYPQPEYSGIEINDPVLPIASIYQPDLPNQKQVKGVIKVENQLIRNEPISSENQKVNVHIQPTKIESFNIIQENQVAKTPPVSYGLVHHGANIDAHVINHNDMFSSVLPSNDQNNNRKPFPPNQNIGNSEIPVDQNVINYRRPTHIHSRPIYNQEGVADPFAHRLPNGPAPQSPNNKHPQLQKYNNNKKNILRPNYISQKQQPEISEFMLPPTTPRLQNKRPYDQKQTSRPISIPVGPEKQQSPKLPPDFKPSYPIFEVHLPPSNVNHQPVQPIQSNHPQKPVQSIQSNYPHEPVKKIQSNYPHEPVQTIQSNYPHEPVQTIQSNYPHEPVQTIQSNYPHEPVQQIQFNHPHKPVQPIQSNYHEINMNQEVGNHKEDDLENEDGEVVQESNSRPLLPGEIPHEIVKMQSSSTERPESRPVFTGHTPLKLQDHASQIPKEKVIYNQTTIGIDLLHSINNAFNEVNNENIDNLNAIPTQDQIIYTISQKPIVFRDEVPIHNFGTTQKPIVFRDEIPMHNFGTTQKPVLIFIDEDEKTKETFFNKENKDRPTVTSLPINTFKETLFSYPINKDRPTVTSLPINRFKDYNRENPKAPLQNISPFKENNYKERPTVTSLPINNFNEYNRERPVTSSQGINLYNDINRERPSIGSQPIHINTTKNTYRERPSVTSLPINNNREKPPYNFNSYKDSNLGRPTSTSQPPHTFKENTYRERPTVTSLPINNFKEYNREKPITSPYNINIYKDYRRPTASPRPVTNYKEFNNRPAVTSLPIDKFQIFNNRERPPITSIASDKDQILRIGTQTEKPFSGVPSKTISFNEIVKKDVLLPKPSKNANTPRTTSTPLSTVDRESQFNTGEIPLNYNNSIKQITDMEIMKPPPPPQDVSKQPPNIYTAVPTDNQQPLYTPNISEEMVPPPPQPPQDTQKVIGMVPPPLTSPKLPPTVTTPKYSMEVDVPSTKPTTSTTTEVNRHRTRRPFTRRPGYRTTTTISSTSSTTTTPRRRPVYPGYTNKPTEETKSTTPKTTISPSPSIKIKPSLEVIIGNPTLESEPTKSSSSTVELSSSEASISTQKVLSEPDLLGMESGIPAESIDSNNVPDVVTPGVHHAGNEIKVILDATTPLPSTIKTVYNETKSKVPIPTRYITHTKTATVTITKTTVIKSLGIPSTLTILVTKTEKMTIVDTVTEVHTLVKPTSIIETITTTVKQASSLYPDDAYGSPYPSIQVKPTLLAPFLNYNDTVYGESSEDNLEDFIIHETDPPIPKQKEPQVHPEDNDSFLVVMTDKNTKSIVKVPASYEPPERDEVITTNKDNNVLLAGILLNHPEEQQEKVLDRCEPECKASRNELCQKLGGHMRCICRPGFARMFPDRPCLPTYTFDLKITLDRIGKDPLHFYEDLRNTNSTEHYKFVQATGEALDRMVMQSDLRDIFHGVKVHTFEPATKGIVSKFHLQLSENIEEHKLEDVLKTYLRNNSFSLGGTDIFASPLMELEAHDFNECAHTNLHDCSENAHCFNLKGTYSCSCKEGFSDMSENMLYPGRVCSAEQVGCEKCNYHGTCYSRGADEVLCECFQWYTGQYCHINLKVLLIALVTLGTVLFGLLLTCIILTCVKGKPRPVGVAGGISILPQGASARRNTLDRRAMIQDTSSEEDNKSETSRYVKKQKPAPQKKASKVSLQVAERGEGGATNHGITFDDQKDRSLTVMIPRAKYHPAPHTSPLSNYTTFDVRKPSVPSIPNEAKLLSFLDAGPCPSKSEPVRKFSNAPSESLIEEKPSSRKTSGALISAGFEVSATVVNNMGTLGTTCGTEADRSENATLIQKISADLLSSTGTRSQFNTLRKSLVDDDLKSEIHMDSESNWLDMLPRVMTVSEARSYDETTIPPPMKCLRTDYDSKPSSQHPNDEANTMAERDLGSTFMLPHTHLYKPDRGSDISGFESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSL8</accession>
    <name>A0ABM5KSL8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513184.1">
        <property type="nucleotide sequence ID" value="XM_050657227.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657227.1">
        <property type="protein sequence ID" value="XP_050513184.1"/>
        <property type="gene ID" value="LOC114326547"/>
    </dbReference>
    <dbReference type="GeneID" id="114326547"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="530" mass="60678" checksum="ACB134EB52D3473A" modified="2025-10-08" version="1">MSTSNNVKSKKSSKDREKRKSLPSTSNANDSNTSDKGSSEQDGMQYAGIGPDTIRNYAEQTMHEAHLSDEVCNLLSEDINYKLRYIIHDALLTARLHGDNVITSKDIDESFKNLSIEKVYGASTTPNWVPFSDVPGANSTDQLFYYLDDSVVNLVELAEEEPTYVQHGDIILTKSWYPDSESENVSEAYQNYFKTACQCVISGDEELREVTLKDISENSKIGPISQWFYNFGYFLLIKNITYDSLTLRALDLIETLENSPIPSSTASHKSLQLLVRLLLQRLLLSYTSPDILKRMCFTLSILCLREPLRQLAISKINQKIDVIGQGAMLPVLTIIYYLGVDAVKAIFLPRVTFFLDQVVKDNGEMIYFILAIYGVICHADLDDEYTHNWFDATIPNDLVIYWKSFHRRKDDEKMEINFASMKCKLILTRRKIDWTSRINSKPSLEEILNIGDINLLNSYLHNIEEVFALPPHDCSIRTKIDEHRRNRQVYRKQTHAEVGKTSLLLSVLNSSQKRKRISNCYGHSLKDYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT50</accession>
    <name>A0ABM5KT50_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.4</ecNumber>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="4"/>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050513368.1">
        <property type="nucleotide sequence ID" value="XM_050657411.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657411.1">
        <property type="protein sequence ID" value="XP_050513368.1"/>
        <property type="gene ID" value="LOC126889286"/>
    </dbReference>
    <dbReference type="GeneID" id="126889286"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="329" mass="34620" checksum="CFDF48D0B7E980C3" modified="2025-10-08" version="1">MSVSRFKLLLPPKILSTQSMRFNYDKSRKNIILSKATKVIVQGFTGKSGTAHAKLCLEYGTLIVGGINPKKGGQKHLNLPIFATVKEAKAAVKPEASIIFVPPPTAAAAILESIMAEIPLIVVITDGIPQHDMVRVRHALIGQTKSRVIGPNCPGIIASGQCKIGIMPNAIHKQGMVGIVSRSGTLTYEAVDQTTKLGLGQTTVVGIGGDPFNGTSFIDVLEIFLQDPKTKGIVIIGEIGGVQEEQAAEYLKVHNVGPNAKPVVAYIAGLSAPPGRRMGHAGAIISGGRGKAGDKIKALEKVGVKVTGVLTQIGQTMYNALKETGKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT72</accession>
    <name>A0ABM5KT72_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6451 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513376.1">
        <property type="nucleotide sequence ID" value="XM_050657419.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657419.1">
        <property type="protein sequence ID" value="XP_050513376.1"/>
        <property type="gene ID" value="LOC126889292"/>
    </dbReference>
    <dbReference type="GeneID" id="126889292"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045609">
        <property type="entry name" value="DUF6451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF25">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20049">
        <property type="entry name" value="DUF6451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6451" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="25460" checksum="E0454C7C03ACE175" modified="2025-10-08" version="1">MRINARNNTLFNIDNMQIENVENFTYLGSGITESGGTENDIRMRIGKVQQAFSMLNPVWRSGEYTTRTKIRIFQSNVMSVLLYGCETWKVTKSLTDKLQIFVNKCLRRIVRIFWPKTIRNEDLLHLTQQKRVENEIKSRKWGWIGHTLRKDNSSIAKTALEWNPQGKRKRCRPAQTWRRYIMDEIRSQGKSWNEVKALAQNRTRWRVFTEALCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KV26</accession>
    <name>A0ABM5KV26_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="6">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050514040.1">
        <property type="nucleotide sequence ID" value="XM_050658083.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658083.1">
        <property type="protein sequence ID" value="XP_050514040.1"/>
        <property type="gene ID" value="LOC126889608"/>
    </dbReference>
    <dbReference type="GeneID" id="126889608"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="48112" checksum="BE1D1050606AF905" modified="2025-10-08" version="1">MKVAVIGAGASGVSSAKHIKENGFECDVFEMAEGLGGTWIYTDDVGEDKYGFPVYSAMYKNLRTNLPKEVMGFPDFPVASDKKSYLTQNEVLELLNQYVDHFQLRNLIKFNCMVTDVRPVKENKWQLTYIHKPSKEYHTLIYDAIMVCNGHYNQPFWPKFEGQEHFSGTIDHSHTFRSAHKFEGKNVIIVGAGPSGLDLTLQVSKYAEKVYFSHHSSQAAKTIFPINVEHKPDIKRIIDGGTVEFVDDSCCCVDAIILCIGYKYNFPFLHESCGITVDDNFIQPLYKHMINLEMPTMCFIGIPFTVCTFHMFDLQARYFCKYLNGSLSLPSTEEMREDTNKDMQRRWANGIQKKQAHAMGEYQQEYYDDLASAADTKPINPVLVKLRDYSVQQLYENLIHFRENKYKIIDRETFVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWM6</accession>
    <name>A0ABM5KWM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514594.1">
        <property type="nucleotide sequence ID" value="XM_050658637.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658637.1">
        <property type="protein sequence ID" value="XP_050514594.1"/>
        <property type="gene ID" value="LOC126889913"/>
    </dbReference>
    <dbReference type="GeneID" id="126889913"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="124"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="404" mass="47092" checksum="D1C64F2FA34AC57A" modified="2025-10-08" version="1">MEALYPEVLTILKNIAVSEGFTEPQITSSGQMDNGEGFSGNVIFISITDKQRTKGLDIVVKQSNLNENVRDAIPVHTLYKNESYFYNRIWPELCKLQKTLPNIHRLNNIPKCFATDVHKDKECLIMENLMTQQFETIEKTATFSNEEVKYILTKYGKFHGLSFAYKAQYPDNFNEFCKMLSPYWKVQGDGKLFVSCLKDAVKKCEKYFGSSKDSKVTEALEKFSKNCVDLYKNSVTYRGNYGVITHGDCWSNNMMFKFGKNGKIEDMKFIDFQASSKASVVQDLSYFLYSGCDKQVLDNLDEYLMVYHKSLVETCSMLNCKEYISFEELKSEWKEYSFFGFMMSLIVFVVKYAIPEDMKKADMNKLCEEFNSGKELEYEVRIDEKMMEIKYKTIFNHMVEYNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXK8</accession>
    <name>A0ABM5KXK8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514920.1">
        <property type="nucleotide sequence ID" value="XM_050658963.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658963.1">
        <property type="protein sequence ID" value="XP_050514920.1"/>
        <property type="gene ID" value="LOC126890116"/>
    </dbReference>
    <dbReference type="GeneID" id="126890116"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40360" checksum="FEC8FDB4FCAE280A" modified="2025-10-08" version="1">MIQNFQISLLSSGNTQEFGQYFQKCYLHNMESWAYCYRLHAGINTNMSIERMHQTIKYLYLNGRQVRRLDKTINILIKLIKDTLFERLVTLNKGKISSKLRELRKRHKTSLNIDMDTIVMSEMGWEIPSSSTNDIYLVQKNKPSCDCQLVCNLCQSCLHSYSCTCLDNSIRWNMCKHIHLVCQFMKGHQIQDTNADEEHIINTDEVKIKQATEQAKFVEFVSKSCNINQEKTSKQLEVEKQKLIEIQTQIIQNITNFEQLEAFKSITAPLVPTLRTLAEHSGNELNSVALSHGTQNIPHNKKVVSQKRLFSTKKKTTKSKKKLLSKPDAEETNLIANQLMLQVNNVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXV1</accession>
    <name>A0ABM5KXV1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515021.1">
        <property type="nucleotide sequence ID" value="XM_050659064.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659064.1">
        <property type="protein sequence ID" value="XP_050515021.1"/>
        <property type="gene ID" value="LOC126890210"/>
    </dbReference>
    <dbReference type="GeneID" id="126890210"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51986" checksum="2D3B5E638A96CFD8" modified="2025-10-08" version="1">MCPDLPVNKIDTSTSSISRSEENRSEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHAPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVVKLWELNIIGITDPVEKLAREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQIIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY46</accession>
    <name>A0ABM5KY46_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515114.1">
        <property type="nucleotide sequence ID" value="XM_050659157.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659157.1">
        <property type="protein sequence ID" value="XP_050515114.1"/>
        <property type="gene ID" value="LOC126890299"/>
    </dbReference>
    <dbReference type="GeneID" id="126890299"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="113239" checksum="6BBCB6F07A705F3C" modified="2025-10-08" version="1">MALELETKRRTVLRTAFTTAANVLDNLLSETVDTRPWQRISVQWELLQVKYNELCVVESAVFEAMVEKASEAELISEMEAKDRYSTRYYELNYKCEDRPSLVSSESSIKGKRSFKLPPIEFKKYSGDLIDWLPFWSQFKVVHDDPSIDLNDKIAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEEYAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKCKSNNLVEKKNIKLPKQGTDQPSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKNCRARLNCILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLWELDIIGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGWESSVFHLLKDNFARNAICPTHSKDSQMHLDCREMYLPNPAFGNLILTLVMMFFFEMAASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYL8</accession>
    <name>A0ABM5KYL8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dedicator of cytokinesis protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515280.1">
        <property type="nucleotide sequence ID" value="XM_050659323.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659323.1">
        <property type="protein sequence ID" value="XP_050515280.1"/>
        <property type="gene ID" value="LOC114336054"/>
    </dbReference>
    <dbReference type="GeneID" id="114336054"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11872">
        <property type="entry name" value="SH3_DOCK_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF12">
        <property type="entry name" value="SPONGE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="10">
        <location>
            <begin position="420"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1688"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1858"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1902"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1695"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1876"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1924"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1968"/>
            <end position="1980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1980" mass="228000" checksum="E4130BE498F46ABB" modified="2025-10-08" version="1">MWIPTKTKKYGVAIYNWKGDTKFGLSLEIGDTVQILEECQGWYRGFSSKNRAHKGIFPQSYIYLKPCKVDNEGLFESIVPLEDPIVREVTLVLREWGRIWKGIFVDRNHYKFETVGKVMRDLLEWRRQLVLGTLTHDQTTDLKLKIIQKIDWGNRKLGLDLVPRQGANMVEPDSMSVVELYHVHVASAENIQGVSARGTIKRKEQKKTLTHHLYFCMRDFGHHIGEDTEIYFSLYDASKQKYITERFLVKISKDGFSNYVEKLHSNCTIFADLGSAELNKDIYIVAHIMRIGRMLYSDSSKKTDKLAAQQQIFKRPHGVAVQNLGDSLTSKESDTEEKEFNMKVYQAEEKDFHQLHEFIIKQSGKFSALSGHINYGIMISVKMLHGELRSITEENALLFKNVCLTSKLGFPDVIMPGDVRNDLYLYIDRGEFERGGKSTGKNIEVSVVVLDSEKKIIKNCLWGASGMEPTSEYNSMIIYHHNSPVWAENVRLTLPIDKFAGAHVRLEYRHCSTREKNDKKLFGFSFLRLMDKEGAAVQDGQHDLYIYKCEDPPKLENCGYLSLPAFAKDFEGNHDASGQFSRSHKEIVTIKTLLCSTKLTQNVDLLALLRWKSHPERIPESLHRVLNLGDEEFIKFLQDVLDALFALFSTEDGNSTAHSGPVFHVLVSIFNLLDGSKYQYFKPVLEAYIKNHFSAALVYKGLLTSVQHCADWVSSFEKQEPIQKCFKSLEYIFKLIIQSRLLFSRATGGHFEDSFRRDLFSVFVSLNKMLSITDNHIINTQVALLITISSVYEQLIDVLPPLEVTRLAANMLDSLPRDLPVLLIQAKLSCIKNIVTGKLFQDDESRNILLATTCKHLRYHLIRREELKLCTDILGEILGYLFKQRKSGDEHGKVNNCIHHDVDTLCVAILEVLIQTILTSIDKDVKVFGCLVACLIGILQLIDEFHYKRLWEVVMGPHQDRKPLKDFLLRAFLVFRNLVRMEVFPPDWLVIKMLTNNVILKALQEFAQPLAFKFLDNRAGYFDKELWTNYFNLSVDYLTQDSLQLEQFSEVKREKIIEKYGDMRVLMGFQILSMWSQLGEFKLHFIPSMVGPFLEVTLVPEIELRKATLHIFFDMMECEQKARGNFKQVECELIDKLDILISENKGDDEYRRLFNTMEHLSAVLLDRVQSEEPVWKESGVAFISSITRLLERLLDYRNVIQGNKNRDKRMSCTFNLLNFYKNEINRKEMYLRYIRKLHDLHLSAENYTEAAFTLKLHADQLNWNNNQISDNNYPGHSECQVKELLYRQIINYFDKGKCWEKGIPLLKELANLYETIFFDYKLLSDILRYQAKFYDNILTQLRPEPEYFRVGFYGLSFPLFVRNKQFVYRGLEYERIGAFTQRLQTEFPSAQILMKNTPPDDAIINSDAQYIQICNVKPITEPNAITLASDIPEKIARYYHYNDVRRFQCDRPVHKGIIDKDNEIKTLWIERTILEISNPLPGILRWFEVVNRQSDEIPPVQYACETMRNVENELRQLITIHSMDPKRNLNPFTMRLQGIIDANVQGGISKYQQAFFTKEFVKLYPEHKVYAENLRELIINATRVIEEGLILHGKLAPQSVQPLHQRLLERFIQLKESLGAFNQQSTNSIVNTPLPPVPTDKRLLMENGSNRSSGSSGNYGHLVEHHTAEYDNIYTKPADNERHTMNRENLSLPMPITPIAPPIPQRECRPRSQGFSNTSFAELRTPTRGPLEYNSASLPSMKSRDSESGDLPLPPKPTHSRERSLTKPPSPRLLRHAMSMTPTDSPHLRNSWPESGTLEEAPPLPPRSHTPDKRVQSLPNENPPNIPKRGQKKSTQSMCSVEYFPLEDSTQETNLVTSTNSLSTHVDSHDLRDSGISMTEPQMNNFNNASYEDYDFRTNQSEMNINSSSSPKAENENPPPIPPKSSLSSLNSSFDLGGSLERPKRREEVDVLSPVESYSYPVIHKENGTTASCTEKNAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0H1</accession>
    <name>A0ABM5L0H1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_050515938.1">
        <property type="nucleotide sequence ID" value="XM_050659981.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659981.1">
        <property type="protein sequence ID" value="XP_050515938.1"/>
        <property type="gene ID" value="LOC126890792"/>
    </dbReference>
    <dbReference type="GeneID" id="126890792"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="141"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="262"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="453" mass="52097" checksum="25A50DCA04B6780C" modified="2025-10-08" version="1">MSIGNGLSLKMPPRLSARRIFLIILVLFSFSVLISVHHRFSWIRIGSGPSLQENQDDPEINDIGDDPPSSGRLEISNEVGEVEEPTAKENQGKPWFMKGGTEFPGNYRGPPRLFPDQADGDRIVEQLMYVPEDYQGYDTPEKVILAYNGLGAWGQKSGSASFHGCPVNRCTLTDDRSKAADVDAILYKDHFIHPGVARPMKQIWIIYFLECPYHTQSVKFADLINWTATYRRDSDLVAPYERWTYFDPQVRQKVQSKDYSVNKTKKVAWFVSNCGARNGRLAYARELGKYIPVDIYGTCGPLKCPRSDRKCFEILERDYKFYLAFENSNCRDYITEKFYVNGLGQNVLPIVMGARPEDYQRSAPEGSYIHVDEFAGPQELAAYLHRLDNDNNLYNSYFKWKGTGEFINTYFWCRLCAMMHAPQSTQRHYEDVNDWWRGPGVCTTKSWRNAEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1U9</accession>
    <name>A0ABM5L1U9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516413.1">
        <property type="nucleotide sequence ID" value="XM_050660456.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660456.1">
        <property type="protein sequence ID" value="XP_050516413.1"/>
        <property type="gene ID" value="LOC126891277"/>
    </dbReference>
    <dbReference type="GeneID" id="126891277"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="150077" checksum="2C976CEBE5D536B4" modified="2025-10-08" version="1">MLAKLIQVIATILGLIKNDYNAEKLRQGLIECNKASKKLRDSMRYAKTIGEKQHLEAQMRKVKTLRNQLKAKQKKGAGLTPTKETAKHRVHWDDSLSAFNSRIRTGVISNLKHKDPSSFLIDCKALFKRRIQNVLKENEAVKVNMAFGGEFEVASGDKILNETKYFTTSNSPIYKDTNLDEWFEKKVVEPISRDMEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIDLPPQIKRKQACINVKNDDEACFAWAVISALYPTTKNVDLLSSYPQYSSILKLKGIQWPMTIKQIPNFEQQNNISINVYILKKEKNYTTLPTFITKNKKDKHVNLLLVQDTYEEQGTPIRYHYVWIKNLSRLLSTQLSKEKRTKYFCDTCLHYFRSQEQLNVHTTCCKGRSDVICDRCLQPFSSSKQLEAHTNDCVRINTTAIKMPEQSRKMLRFKNFRNKIKAPFAVYADLESALKRTGDPKKHQEHIPVAVGYFFKCSYNDTISFYKSYRGKDCMKWFVDELNQLAENVSTVFICPYDINMTSQQESDFHAATHCHICEQRFSLDDKKVRDHDHLTPDNNYRGAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVNDIATHIKGPVDLLPITKEKYISFTKHIDDARIRFRFIDSFRFMASSLDKLSSYLIEYPNLRSQYTSLPEENFHLLTKKGIMPYDYIDSFIKFSETSLPPIESFYNKLEDKPCPRRHYRRAQDVWSSFSCSTLGDYIDLYMKTDILLLADVFEQFRSSCLKTYNLDPAHYFTLPGFTWDAMLKHTKQKLELLTDPDMFLFAERGILGGLSQVCSKRRVHANNKYMESYDPSQPDSYLMYFDVNNQYGWAMSQYLPYGSFGWVDANIDILSIPDDASEGYFLEVDLKYPQHIHDRHKDLPFCPQSLNPKTMLPPKRPREQTKLMATLHDKERYVIHYRTLKQALAHGLILKKIHRVLKFKQSPWLKSYIDLNTDLRKAAKNEFEKNLFKLMNNAVFGKTMENVRKRVDIKLLTEWEGRYGAEARISSPLFKNAIIFNENLVAVEMHRAEIWLDKPIYVGMSILDLAKTTIYDFDYGYLDRRFGENFTTCYTDTDSVIVEIREKDPYEAMKTDCHQHFDTSDYPKDNIYGIPQVNKKVLGMMKDENNGCIMTDYIGLRSKLYTTKVAITDNDITKLRGKLIDQEYEDDEIEILIKNYGVTKKAKGVKKSVVNTKITFEDYIECLDTFTTKTASQNLIRSDKHHVYTITQSNIALSPYDDKRHHLPESYDTLPWGHYLIDNLEMDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1Z5</accession>
    <name>A0ABM5L1Z5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516466.1">
        <property type="nucleotide sequence ID" value="XM_050660509.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660509.1">
        <property type="protein sequence ID" value="XP_050516466.1"/>
        <property type="gene ID" value="LOC126891332"/>
    </dbReference>
    <dbReference type="GeneID" id="126891332"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="610" mass="68937" checksum="2B2489AAF2C0908F" modified="2025-10-08" version="1">MPNFYKRKTSQQSWDEKAMAEALTACQGGLSIHSSAKQYNIPSTTLFRRLKRPPEERLVKQLGRFRCVFTVDQERMLVDYILKMEERLFGLTISDLKYLTYEFAIRNNIEHRFNNEKKEAGKVWLLGFMKRHPVLSLRLPEKTSAARASAFNAVSVGKFFDLLEDLYQKHNYKPNRIYNCDETGISTVPNKPSKIISKKGKKQVGVLSSAERGTLTTAAICFNAAGEYIPPALIFPRVRHHLTFDIGVSLNTKIFTHASGWMQTEIFTAWFHHFIKFAKPTSEDRVLLILDGHSTHIKNIEVLELAKKNFVDILVLPPHCTHRLQPLDVSFMYPMSTFYKQAVRVWLRTHPGKVVTIHDVGPLFGEAYLKAASMATAISGFKKTGIWPFERPDPNVFVAADTTDRPGPLLATSNLPSASTPVSNDILLHKTIVSPADILPIPRVASNIENPTKKRARSGKTVVATSTPFIEELKNLKAPTPKNPTKKVTKQLFQSDSEEEDDANISIYSDTDSGSELDLPVQIPTIKTEDIKEGIYVAVEYNGQTFPGLVISKSGESASVKCMERTQKYLKWPNKDDVLDYNIKDIKMIINEPKQLRRGFFNVPELCLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2M4</accession>
    <name>A0ABM5L2M4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516694.1">
        <property type="nucleotide sequence ID" value="XM_050660737.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660737.1">
        <property type="protein sequence ID" value="XP_050516694.1"/>
        <property type="gene ID" value="LOC114337364"/>
    </dbReference>
    <dbReference type="GeneID" id="114337364"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
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    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF16">
        <property type="entry name" value="PROTEIN SPAETZLE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045075006" description="Spaetzle domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="236"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF16077"/>
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    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="338" mass="39208" checksum="F4F03C2C9616636C" modified="2025-10-08" version="1">MRLNIGLKLTIWLANLVVYCSSVCSPHYGAEPCIYDYTPAPPGKTPPCARPGLTYCEYPEQYPGQLIHFLVKHWKYDHQSLFSSESKDDFDSYYYPTTSPVYGPPNYRPPYTGRHSIGYPEPIYIPKPQIPFQENGYIPPSYHHRPNYTNYDTSGGYHYGPPSKANIYYQPYQQTLEHHPQYGQYNSLWKRALDQNYRRYKRSLRKKRMLPFIPVEKFANGTLHRSKRQDPGKTVLCRTRVDYITPRAALNNQGNWRYIVNMPEVNQRVTQLVKSEKCASTTCDGICQLPDNFVSKCEQKYVQKRLVALGAGEGSGELYTDLFWFPSCCLCTIQRVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L581</accession>
    <name>A0ABM5L581_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517594.1">
        <property type="nucleotide sequence ID" value="XM_050661637.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050661637.1">
        <property type="protein sequence ID" value="XP_050517594.1"/>
        <property type="gene ID" value="LOC126892166"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF16064">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="263" mass="30435" checksum="6BFC06822CED3FD4" modified="2025-10-08" version="1">MLVKAVAAIKSDFDAKLLSAMQNFKNNHQDDDNIQFEFHAVSTSQELSQLEENLKDPNYEKKVRNYFKKIIGNIPDTSNGLDTCYSIVDYFFEKKFMVQCSWTGGSRSNTEKCCIKNCKNILEVFFTIVQSSNKDFSKALLKKFIIGITRNAKKRSLTGGIRQSSIHRRKKSMVKKQRLSGNRKGVAQRQGKGTYIKKMYNIKIIISGENEFFYENEQSFNEEKEYDEDNDEHGMEKYEADGEDAIIEHDEVEEEDNNDTDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L708</accession>
    <name>A0ABM5L708_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050518230.1">
        <property type="nucleotide sequence ID" value="XM_050662273.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662273.1">
        <property type="protein sequence ID" value="XP_050518230.1"/>
        <property type="gene ID" value="LOC114335360"/>
    </dbReference>
    <dbReference type="GeneID" id="114335360"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="25"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="887" mass="104984" checksum="B337FD9A81713600" modified="2025-10-08" version="1">MESSEDSIKSEQNVLICNKHGDSLEQQHVINLQIKSELEECTFERDYTDHSSDSYCSDDIKIEEHKLQCEISSPFPLIMEPEVKTEIKKELDEHNLGVSHGCETQYKSRDTKELDLDKDVKLQIEASTETDHEKHSRSVKTSKLLSNIGKQSLRQNEIKTRYEGSLATHTEKKPYKCKTCFKQFSQERNLKMHLRVHTGENLYKCEICYKQFSQERDLKIHLRVHTGEKPYKCEICFKQFSQKGHLKIHLRTHTEEKPYECEICSKQFSQAGNLKKHLSIHTGAKPYKCEICCKQFSQKYYLNDHLKLHTGEKPYKCEICFKKFSENGSLKKHLRIHTGEKPYKCEICSKQFSRDEHLKKHLRIHTGEKPYRCDICSKQFSEAGSLKSHLRIHIGEKPYKCQICSKRFSQTSHLKRHLRIHDGKKPYKCQICSQQFSHDTSLKMHLRIHTGEKPYKCEICFKQFSQQGNLKIHLRVHTREKPYTCKICSEQFSHDTSLKMHLRIHTGEKPYKCEICFKQFSQQGSLKIHLRTHTEEKPYECGICSKHFKHVGILKTHLRLHTGEKPYRCEICSKQFSLQGHLKSHLRTHTEEKPYQCEICFKQFKHLNLKTHLRLHTGEKPYKCEICFKQFRQEGNLKTHLRTHTEEKPYQCEICSKQFKNVRSIKTHLMLHTGEKPYKCKICSKQFSLEGNLKIHLRTHTGEKPYKCEICFKQFSQDGHLKSHLRIHTEEKPYKCEICSKQFSQDDYLKKHLRIHTEEKPYECEICSKQFKHLRNLKTHLMIHTGEKPYKCKICSKQFSIEGNLKIHLRTHTGEKPYKCEICSKQFSQDGHLKTHLRIHTGEKPYRCEICSKQFSENGHLKRHLRIHTSEKPYPKFVLSNLVKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8Y3</accession>
    <name>A0ABM5L8Y3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cathepsin L1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518901.1">
        <property type="nucleotide sequence ID" value="XM_050662944.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662944.1">
        <property type="protein sequence ID" value="XP_050518901.1"/>
        <property type="gene ID" value="LOC126893007"/>
    </dbReference>
    <dbReference type="GeneID" id="126893007"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="3">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34520" checksum="191B7C3377F8BCD1" modified="2025-10-08" version="1">MASRQKYNKCYSNYHDSSRRKAWEENLGIIKKHNQEAVQGKHSYFIKENHLTDMSNRQYLQNMVKLTKSRHRKVDADKERNVFEKFMNLPSEVNWIEKGFKTPSYNQKDCGACYAFSIAGAIQAQVFKQTHQLVPLSEQQIVDCSLPFGNYGCAGGSLRNTLRYLEKVGGLMAYKDYPYKSRKQRCVYDKNKALVNITSWAVLPARDEQALEVALAKVGPVAASINASPRTFQLYHHGIYDDSSCSSDHVNHAMLVVGYTKDAWILKNWWGKHWGENGYMRLRRHKNRCGISNYAAYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U2C7I3</accession>
    <name>A0A0U2C7I3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114343389</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2015-03" db="EMBL/GenBank/DDBJ databases">
            <title>Developing methods for Apis mellifera L. larvae and adults RNAi risk assessment.</title>
            <authorList>
                <person name="Velez A.M."/>
                <person name="Jurzenski J."/>
                <person name="Matz N."/>
                <person name="Zhou X."/>
                <person name="Wang H."/>
                <person name="Ellis M."/>
                <person name="Siegfried B.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KR024028">
        <property type="protein sequence ID" value="AKJ26286.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150007.1">
        <property type="nucleotide sequence ID" value="XM_028294206.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506367.1">
        <property type="nucleotide sequence ID" value="XM_050650410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U2C7I3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650410.1">
        <property type="protein sequence ID" value="XP_050506367.1"/>
        <property type="gene ID" value="LOC114343389"/>
    </dbReference>
    <dbReference type="GeneID" id="114343389"/>
    <dbReference type="KEGG" id="dvv:114343389"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="14">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="12">
        <location>
            <begin position="226"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="15">
        <location>
            <begin position="460"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKJ26286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028150007.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="67968" checksum="7F9BDB912F386749" modified="2016-03-16" version="1">MSKVRIGDEEKEGQYGYVHAVSGPVVTAEKMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDICDATDSIYIPKGINVPSLSRTAKWDFNPINIKLGSHLTGGDIYGLVHENTLVKHKMILPPRAKGTVTYIAEPGNYTVDEVVLETEFDGDRTKYTMLQVWPVRQARPVSEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTVEIDGHTESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPDREGSVSIVGAVSPPGGDFSDPVTTATLGIVQVFWGLDKKLAQRKHFPSVDWLGSYSKYLRALDDFYDKNFQEFIPLRTKVKEILQEEDDLAEIVQLVGKASLAETDKITLEIARLLKEDFLQQNSYSSYDRFCPFYKTVGMLRNMIGLYDMARHAVESTAQSENKITWNVIRDSMSGILYQLSSMKFKDPVKDGEAKIKADFDQLYEDIQQAFRNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F293</accession>
    <name>A0A6P7F293_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC114325577 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114325577</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129476.1">
        <property type="nucleotide sequence ID" value="XM_028273675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F293"/>
    <dbReference type="FunCoup" id="A0A6P7F293">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273675.2">
        <property type="protein sequence ID" value="XP_028129476.1"/>
        <property type="gene ID" value="LOC114325577"/>
    </dbReference>
    <dbReference type="GeneID" id="114325577"/>
    <dbReference type="KEGG" id="dvv:114325577"/>
    <dbReference type="CTD" id="34395"/>
    <dbReference type="InParanoid" id="A0A6P7F293"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000002">
        <property type="entry name" value="Gata transcription factor gatad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="442"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028129476.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="72498" checksum="53E97CB38304CD6D" modified="2020-12-02" version="1">MCNVPPKFYQLCRLCLSHDKDNALFIFDKAAMERNILKKIMTCLSILVSEKDELPHVICFSCSEQIEYLYKFNELAKKTEGILHQFLVYTKELQGSDEEKMHQSEKLLENLRLSLTMTPQNLKVEAPEPPSSNNKELSHQKAQHPTVVRPPEIKSEPPIFMEQTRQTYKHVDTEPVITPKVEIVERIPSPPTPPQDLSMDLSKDSTEHEEPSMREPLIKVKPASVLQQYPPEPQNLPEITTSPMVHQDFSSAPIEPTDLSNKRMEKVTCVPEISFIKEEADAVSISSNSSDPERLEVDMSQINEEHSDSTLSETSPTSEPTFNHSDVDPAVLQALSRNGYNPPLSGEASQLLRKLITCRKLGMTITPAQPHVLNYTLFDEQQKSLEHTNAEKSRRKQSYPSKASVSDSVPMDQDEEEEYGPDFTGNSPWCNMVKGKRVEVPKRVALSCTNCGTQTTTIWRRNLRGEMVCNACGLYFKLHNIDRPVTMRRDTIHTRRRRPKAAEREKADYSPVVGNFVNPPVHTYKAYKAKIVKVSASKERRAAESSDTDDMLSALRRQLRPHLVMALQGHRNNSNENMNLDSSPKVPSRAHIQGPTVPNFLPIEKMPSVGVVSAREADSDEDSIADLPLNLVSTQMTEGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6Q2</accession>
    <name>A0A6P7F6Q2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase-activating protein 19 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114326910</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131171.1">
        <property type="nucleotide sequence ID" value="XM_028275370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6Q2"/>
    <dbReference type="FunCoup" id="A0A6P7F6Q2">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275370.2">
        <property type="protein sequence ID" value="XP_028131171.1"/>
        <property type="gene ID" value="LOC114326910"/>
    </dbReference>
    <dbReference type="GeneID" id="114326910"/>
    <dbReference type="KEGG" id="dvv:114326910"/>
    <dbReference type="CTD" id="36996"/>
    <dbReference type="InParanoid" id="A0A6P7F6Q2"/>
    <dbReference type="OrthoDB" id="10061772at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="92"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028131171.1"/>
        </source>
    </evidence>
    <sequence length="721" mass="82049" checksum="FDA04D13DCF449B2" modified="2020-12-02" version="1">MHNNIKVYLNLQNGLEPGRAIILFHDLNMNSKNEENEGIIVERFKKDYNEQFFILIRMHLSFLLDAHTDDNDSLPEKSRIKKWNLVPFAKKSKLRGVVEGAALTQEGICQIFQLIEYLKLEENIKSEGIFRKTGSIERQHELKCLLNHGSTLDVGCGSYSVHDCASVLKGFLQELPEPLLTELHFPVYCQLAELYYINNEIPQEQKLLEALQLLQLLLPPENKLLLKDILHLLYQTASFESQNKMSSDNLAKLFTPHLLCPRNLSPAMLLKVSQPLFGIVSFMIKRFPDMFKVPAKLIVDFRAKYEKKRVLSPVKRLNESTADIASTVFTFVDQERTAKENESNPTETALAQLYAHIQSLPESSKKRKLIKQFNKENGYGTPLQVLKSSKNRSIGDSIKKHIFQKHLARRKGFVVKNSPAGPGYESPTGSPSLAMRARLLCYHNYESSTDLTNEGPTPAKRRKTSRSCDRSRSCDRLSEKHDKDNHEDEGKGSFSEPELSEREDSIDCNGYLTSTPACFPLKACTEVFTPNQKDSKSMSPITMSAQRMPRAMQETMMTPRSRKPVLLLSGTNIHTLPKTEPTNYTMDNVIEEKLETPMSNFQTNPPVKSKSEGDINKDTKVDVTKMNKSESDAILSDTFKEYLSNRDIVTIYSPQDSSFSSRTDDFTSTEYTEGQFTESLLYCLDGNNPDESVEEEEEKKLVLKPKQFDENGKPIIFETSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F776</accession>
    <name>A0A6P7F776_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC114327281</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11 12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine</text>
            <dbReference type="Rhea" id="RHEA:46052"/>
            <dbReference type="Rhea" id="RHEA-COMP:17384"/>
            <dbReference type="Rhea" id="RHEA-COMP:17385"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:85643"/>
            <dbReference type="ChEBI" id="CHEBI:85644"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46053"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028131639.1">
        <property type="nucleotide sequence ID" value="XM_028275838.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131640.1">
        <property type="nucleotide sequence ID" value="XM_028275839.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028131641.1">
        <property type="nucleotide sequence ID" value="XM_028275840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F776"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275838.2">
        <property type="protein sequence ID" value="XP_028131639.1"/>
        <property type="gene ID" value="LOC114327281"/>
    </dbReference>
    <dbReference type="GeneID" id="114327281"/>
    <dbReference type="KEGG" id="dvv:114327281"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028131640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028131641.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30831" checksum="607E6B600BFE7DEC" modified="2020-12-02" version="1">MLGKGSLSLLSEYGGDSSDDDGLGPRLSSKRTLEDQDEEGHSFKKRLPVPEVLLKDKQTAEEHVDDPHLHGGRIRSFAHERGNWATFIHIPLDHTEGVLELIHEIIAAIPNIPLISVDDFHISLTKTVILKHHWINSFVDGVRLKTNYLKRFMILFDSLKVYCNEERTRTFIGLQTKTGYDSLIKLVDILNICLSEFKLPSFYNDPSFHMSIIWCVGDYEEELNRILPQLNSKLHDLMDTSNQENWYIYVQFIMCKTGNKHFKFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7U4</accession>
    <name>A0A6P7F7U4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SUN domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114327432</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131854.1">
        <property type="nucleotide sequence ID" value="XM_028276053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7U4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276053.2">
        <property type="protein sequence ID" value="XP_028131854.1"/>
        <property type="gene ID" value="LOC114327432"/>
    </dbReference>
    <dbReference type="GeneID" id="114327432"/>
    <dbReference type="KEGG" id="dvv:114327432"/>
    <dbReference type="InParanoid" id="A0A6P7F7U4"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="141"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028131854.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34574" checksum="457E99A11E1B83AD" modified="2020-12-02" version="1">MRICKSKKVIMNLDPIDICPKPAVYQRSNGRESHLCFWAILMTAILTIIFFLTGIYYDVLSFKDFTETGAYYFEMRNIRYELRYLTDKFDKIDIKRKKCERKILTYLLENEHIIDKKISDALDVYDSDKIGLYDYAALYAGGSVISTPNTSPYLVEHATIFLINMNFLSDPKSILQPTTLPGNCFAFDGTEGRVRIKLARKIEIKAVTMEHIRLDVDRSSAPREFRVYGLPHQNGETPEVLGTFTYQLTGRPYQTFQIVNNDTKAFEIVELHILNNYGKDDYTCIYRFRVHGNYTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAD0</accession>
    <name>A0A6P7FAD0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC114326392</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="22">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028130553.1">
        <property type="nucleotide sequence ID" value="XM_028274752.1"/>
    </dbReference>
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        <property type="interactions" value="484"/>
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        <property type="protein sequence ID" value="XP_028130553.1"/>
        <property type="gene ID" value="LOC114326392"/>
    </dbReference>
    <dbReference type="GeneID" id="114326392"/>
    <dbReference type="KEGG" id="dvv:114326392"/>
    <dbReference type="CTD" id="142678"/>
    <dbReference type="InParanoid" id="A0A6P7FAD0"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="CLUMA_CG014158, isoform A"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase MIB2, putative"/>
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        <property type="entry name" value="Putative e3 ubiquitin-protein ligase mib2"/>
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        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MIB2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
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    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
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    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_ZZ"/>
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    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
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    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="zf-C3HC4_3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ANKYRIN"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="6" id="KW-0808">Transferase</keyword>
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    <keyword evidence="11" id="KW-0862">Zinc</keyword>
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            <begin position="1"/>
            <end position="72"/>
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCB2</accession>
    <name>A0A6P7FCB2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 85-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114327940</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028132462.1">
        <property type="nucleotide sequence ID" value="XM_028276661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCB2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276661.2">
        <property type="protein sequence ID" value="XP_028132462.1"/>
        <property type="gene ID" value="LOC114327940"/>
    </dbReference>
    <dbReference type="GeneID" id="114327940"/>
    <dbReference type="KEGG" id="dvv:114327940"/>
    <dbReference type="InParanoid" id="A0A6P7FCB2"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002388">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028132462.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="65204" checksum="F0E5F03E14B1EC16" modified="2020-12-02" version="1">MDSEESSEDRTFVCSSCNKEFKTLVLFNRHKKTHNSTCEKCNKTFKTFSQLRQHNKEKHPKIKFFKCKVCPDLTFNQEKEFLVHLRNTHEGKIIESHMCNVCGRTFRTSSELTLHIRSKCGTEKQFICKECGQKLMSPGSLYTHLKRHKGENSFMCRFCAKLFLTSGQLKVHERIHTQQKDFVCEVCGKGFCHRQSLITHISLHTGIKPYQCEGCGKSFSCVGNLLKHRRTHADSCGAIPMTSHRVQNPSTKIKVRINTPASSKLKRMQMKKELEEKLANLDKEINEDRDEEVKDEDVKSEDDSSSENTVVQSKDVSKSEEDNNDVKKESSKESSDDDIFNDTDSDSDYLEADDDDDFDIFEKKKSVKSKSRKRQTISIQDEDVENFIKIRKLEKGKTAMCIYCNKEYSNFKWLFKHEQEHKENGDVKEENTVVYTCDTCNKSFDTEVNLKDHEKSEHPKELDISWSSCLQTGLKETEKQDLIQKHATGDFITKYSLELQQHEVISNIQKQICCGLSAIDSYLNKVSKNKEESNSLDILNLVDSAKIFADLYYIVSKDDVDSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDZ1</accession>
    <name>A0A6P7FDZ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114329355</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134219.1">
        <property type="nucleotide sequence ID" value="XM_028278418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDZ1"/>
    <dbReference type="FunCoup" id="A0A6P7FDZ1">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278418.2">
        <property type="protein sequence ID" value="XP_028134219.1"/>
        <property type="gene ID" value="LOC114329355"/>
    </dbReference>
    <dbReference type="GeneID" id="114329355"/>
    <dbReference type="KEGG" id="dvv:114329355"/>
    <dbReference type="CTD" id="37946"/>
    <dbReference type="InParanoid" id="A0A6P7FDZ1"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028134219.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19929" checksum="183D4B81316542A6" modified="2020-12-02" version="1">MGITDDVHLPTEEELTVQEIPLSGPALKAGAFHVGKTCEWENNEFILCRDELKDPRKCINEGKAVTSCAMNFFRKIKATCADEFMQYVNCLDKSSPDQALVPCRKTQAVFDKCVKDNLGLDRPPYDYFNRVHVHKTERPRPPVEGKTVYEDATPGLPEDVPKPEAKYGSRYLFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGV5</accession>
    <name>A0A6P7FGV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydropteridine reductase</fullName>
            <ecNumber evidence="7">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HDHPR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114330042</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:17871"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:17867"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028135141.1">
        <property type="nucleotide sequence ID" value="XM_028279340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGV5"/>
    <dbReference type="FunCoup" id="A0A6P7FGV5">
        <property type="interactions" value="1028"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279340.2">
        <property type="protein sequence ID" value="XP_028135141.1"/>
        <property type="gene ID" value="LOC114330042"/>
    </dbReference>
    <dbReference type="GeneID" id="114330042"/>
    <dbReference type="KEGG" id="dvv:114330042"/>
    <dbReference type="InParanoid" id="A0A6P7FGV5"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028135141.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="24847" checksum="CB38AABDEA497AB8" modified="2020-12-02" version="1">MSYAGRVIVYGGRGALGAKCISHFKANNFWVGSIDLAENAEADVNILVKREDSLQDQETSILSSVNSSLNGSKLDGIFCVAGGWAGGNASKDLVKNSELMWNQSVCSSLIAASLAAQCLKEGGIIQLTGAKAALDATPGMIGYGLAKAAVHHLTKSLSQKDGGLPNNAVAVAILPVTLDTPMNRKWMPKADFSTWTPLEFVADLFIRWASGKDRPQSGSLLKLETTNHQTDVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FW86</accession>
    <name>A0A6P7FW86_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114333388</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139057.1">
        <property type="nucleotide sequence ID" value="XM_028283256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FW86"/>
    <dbReference type="FunCoup" id="A0A6P7FW86">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283256.2">
        <property type="protein sequence ID" value="XP_028139057.1"/>
        <property type="gene ID" value="LOC114333388"/>
    </dbReference>
    <dbReference type="GeneID" id="114333388"/>
    <dbReference type="KEGG" id="dvv:114333388"/>
    <dbReference type="InParanoid" id="A0A6P7FW86"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028139057.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37975" checksum="FFA41F6DDBD06ED1" modified="2020-12-02" version="1">MIPLLLLLIPYCSGLRMDIVTHSSDEVTNSKELHPLSDEFINSINAAKSTWTAGRNFAQDKSMDYIIKLMGVLPDHKNYMPPVLTHKLEALEIPADFDARQQWPHCPTIREIRDQGSCGSCWAFGAVEAMSDRVCIHSNGESNFHFSSDDLVSCCWTCGMGCNGGYPGAAWHYWVRKGLVSGGQYGTKQGCRPYEIPPCEHHTNGSRPACDASEGNTPKCAKSCESNYKINYSNDLHFGSKAYSISSDVKQIQAEILQNGPVEGAFSVYADFVNYKTGVYQHIKGQFLGGHAIRIFGWGVENNTPYWLIANSWNTDWGDSGTFKILRGSDHCGIESGIVAGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZZ2</accession>
    <name>A0A6P7FZZ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper transport protein ATOX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Metal transport protein ATX1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114332459</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with ATP7B. Interacts with ATP7A. Interacts (via dimer form) with SLC31A1 (via C-terminal domain); this interaction improves ATOX1 stability and controls intracellular Cu(I) levels.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138055.1">
        <property type="nucleotide sequence ID" value="XM_028282254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518459.1">
        <property type="nucleotide sequence ID" value="XM_050662502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZZ2"/>
    <dbReference type="FunCoup" id="A0A6P7FZZ2">
        <property type="interactions" value="1109"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662502.1">
        <property type="protein sequence ID" value="XP_050518459.1"/>
        <property type="gene ID" value="LOC114332459"/>
    </dbReference>
    <dbReference type="GeneID" id="114332459"/>
    <dbReference type="KEGG" id="dvv:114332459"/>
    <dbReference type="InParanoid" id="A0A6P7FZZ2"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028138055.1"/>
        </source>
    </evidence>
    <sequence length="72" mass="7885" checksum="AF74679A19E6BAD6" modified="2020-12-02" version="1">MSKVHEFNVKMTCDGCSGAVERVLNKLKDKGVEDFTINLETQKVTVKSSLPANDILEVIKKTGKETTLLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2B8</accession>
    <name>A0A6P7G2B8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial ribosome-associated GTPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114336856</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143046.1">
        <property type="nucleotide sequence ID" value="XM_028287245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2B8"/>
    <dbReference type="FunCoup" id="A0A6P7G2B8">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287245.1">
        <property type="protein sequence ID" value="XP_028143046.1"/>
        <property type="gene ID" value="LOC114336856"/>
    </dbReference>
    <dbReference type="GeneID" id="114336856"/>
    <dbReference type="KEGG" id="dvv:114336856"/>
    <dbReference type="InParanoid" id="A0A6P7G2B8"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008956">
        <property type="entry name" value="PRK12299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="39"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="195"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028143046.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39605" checksum="115A906111B67A19" modified="2020-12-02" version="1">MLNAVKNNIRLASKICQFSQDVAQPLRSKKPKSLKNVVQNFVDLKHLRAIGGKGGDGCISYLSLFSNEFAGPDGGDGGNGGHIIFKSSESVKDLNNVPTVAKAKDGEKGSNKDCSGKNADHLTINVPIGTIIKNAAGKVVGDLSRANLMFVAARGGAGGKGNHYFVSDTQQSPMICEYGADGEDLEYTVEVKSMANVGLIGFPNAGKSTLLRAISRAKPKVAPYPFTTLKPHIGIVQYDDYEQVAVADLPGLIQDSHKNKGLGIEFLRHTERCMALLIILDSSEPEPWKKLEVLQHELSQFNDDLKSRPQLVIANKMDLPGAEANVEELKKMTSLTVIPISAKLGLNIALLLKEVKILYDRQETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4H2</accession>
    <name>A0A6P7G4H2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC114335821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114335821</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141912.1">
        <property type="nucleotide sequence ID" value="XM_028286111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4H2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286111.2">
        <property type="protein sequence ID" value="XP_028141912.1"/>
        <property type="gene ID" value="LOC114335821"/>
    </dbReference>
    <dbReference type="GeneID" id="114335821"/>
    <dbReference type="KEGG" id="dvv:114335821"/>
    <dbReference type="InParanoid" id="A0A6P7G4H2"/>
    <dbReference type="OrthoDB" id="6784167at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028141912.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="26480" checksum="3743F930D552102F" modified="2020-12-02" version="1">MVNICCVFNCANNSKNSKCNFYRFPIIAHKSEKRRRWIRAINRKNGDGSDWTPKPSDRICSAHFVGNKKSENELSPSYIPSIFPYIDGTISKVKHHRKKCCKHQQVVNRHARFIIRRYKGVCTKSNQNIASEYQDNKGADVIVNMREKQAKRETIDAVVDNKMEVSRILTAEKECQVTILNNTSDADEGKSFTCNRFMYIPDRCDAEVQTDIYEYKKIVKTNIVICWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G556</accession>
    <name>A0A6P7G556_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114333857</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028139655.1">
        <property type="nucleotide sequence ID" value="XM_028283854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G556"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283854.2">
        <property type="protein sequence ID" value="XP_028139655.1"/>
        <property type="gene ID" value="LOC114333857"/>
    </dbReference>
    <dbReference type="GeneID" id="114333857"/>
    <dbReference type="KEGG" id="dvv:114333857"/>
    <dbReference type="InParanoid" id="A0A6P7G556"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000042">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF859">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028516620" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="79"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028139655.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="35374" checksum="C7CAD49B6A83DAF6" modified="2020-12-02" version="1">MKFTVSSWFICLFLVYFRCGFARFMLPPVPDVIYPPVPDIVAKMNETLLEEEHMDPELSPGLFQGDMALTNEFYNYWRVGLKFEIFPDKLWRNGIVPYTISPLYEPSEQVTILKAIKMINFMTCVKFVPWDGKSKDYLLIWPMKYPKGCWSFVGRFGGAQILSLQPPDRKGVNCLGTEGRAIHELMHALGVFHEQSRWDRDKFVKIHTDNIIPNYKANFDKQSLENTTYSFEYDYDSIMHYGKFFFAKKKGRPTITTKQPHGAGIGQRKAMSKGDCLKLNDLYGCYKDPSKRRKYYTICNFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6W5</accession>
    <name>A0A6P7G6W5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IQ domain-containing protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114338425</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144826.1">
        <property type="nucleotide sequence ID" value="XM_028289025.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500050.1">
        <property type="nucleotide sequence ID" value="XM_050644093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6W5"/>
    <dbReference type="FunCoup" id="A0A6P7G6W5">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644093.1">
        <property type="protein sequence ID" value="XP_050500050.1"/>
        <property type="gene ID" value="LOC114338425"/>
    </dbReference>
    <dbReference type="GeneID" id="114338425"/>
    <dbReference type="KEGG" id="dvv:114338425"/>
    <dbReference type="InParanoid" id="A0A6P7G6W5"/>
    <dbReference type="OrthoDB" id="10254713at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="230"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028144826.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="40986" checksum="9517CEAB9FFEACB5" modified="2020-12-02" version="1">MSTEDQFQNVLHSEQNTSQDLSTEMCISVLQEMVDALLILKSIGHWPDIDSDIFEYDTPEQRFKKEIYQQGNVSESLCPQNFSFITIFATNLLEELKHERSYLKFSNSVSTIQKMQLDEELLLGETSKKEIIVKKLQMCLDSERDVSIDKLVSSMESIGKIKDQIENFYIQSEIKINYLKSWENSKLEMQEITFSKLIEEITEDIKTTEANINQDIRVHEEIEIAMSEIIQGFEERVEEWKNKYYEKSKEMNEKLDVLQTKQNKQLEIIANYKELYAKRQQEIDDYKKHKIEQERLRLEKEEKNKKATTIQAWWRGVMVRKGFGKFRKKKEKKGKKKSTDKKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G8L1</accession>
    <name>A0A6P7G8L1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114334926</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028140865.1">
        <property type="nucleotide sequence ID" value="XM_028285064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G8L1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285064.2">
        <property type="protein sequence ID" value="XP_028140865.1"/>
        <property type="gene ID" value="LOC114334926"/>
    </dbReference>
    <dbReference type="GeneID" id="114334926"/>
    <dbReference type="KEGG" id="dvv:114334926"/>
    <dbReference type="InParanoid" id="A0A6P7G8L1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028140865.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="27029" checksum="DC68848828CB308A" modified="2020-12-02" version="1">MERICKSDILEQLIFYSHTVFPDNTIYKSEELSSQNEEYKQISKLFKDKNKKIFQIQKIERIHNPYLLTQYAIKKKHLEKLSKQEKTEIPREKRLFHGTGKDEMESICKANFDWRRKGTNVGHRFGQGVSFSANPYYATHYTDDKDEIKVIIVAKVLVGHTCIGNKMMIIPGNCDTSTDKEGQIFIKYDDGTFYPEYRIYYTGFDPEKSCYCQQRTRTISLGDFIPDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAD3</accession>
    <name>A0A6P7GAD3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized histidine-rich protein DDB_G0274557-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114335701</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141783.1">
        <property type="nucleotide sequence ID" value="XM_028285982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAD3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050657400.1">
        <property type="protein sequence ID" value="XP_050513357.1"/>
        <property type="gene ID" value="LOC126889281"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GAD3"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028425358" evidence="2">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028141783.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12847" checksum="ECA5252025FC2608" modified="2020-12-02" version="1">MANNSLLCVLVLVAALNILAIMGAPQHDHHHGNDHHDHHDHGHYDNHYHHGHDYDHHHHGHYDYDNHHHHHGYPSYGYNHYPHYHGHYQYGHGYPYGGVGFNLGPFGIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDK9</accession>
    <name>A0A6P7GDK9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cuticle protein 19.8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114340976</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147564.1">
        <property type="nucleotide sequence ID" value="XM_028291763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDK9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028291763.2">
        <property type="protein sequence ID" value="XP_028147564.1"/>
        <property type="gene ID" value="LOC114340976"/>
    </dbReference>
    <dbReference type="GeneID" id="114340976"/>
    <dbReference type="KEGG" id="dvv:114340976"/>
    <dbReference type="InParanoid" id="A0A6P7GDK9"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027888578" evidence="3">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028147564.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="27976" checksum="7B093FC13D09BCDE" modified="2020-12-02" version="1">MAVKITFSILIAVLLARNRVDASGVAPLFAPAPVLAPAPVLAPAPVLAKVSDATIDPNPAYSFAYDVQDALTGDSKGQVESRANGVVRGQYQVADPDGTRRIVDYYADPVHGFNAVVRRVPLGVAVAPVVAKAVAPVAPIAPVARSLVLPAPGLPVAAAPVPVAPALPFAAPAVAPALPFAAAPAVAPALPFAAPAVAPALPYAAAPAISPYLTRAGFFPAPAPAVVPAAPGPAYLPAAPSRLVSPYSVAAPLPSGLRSLVTPFSAGPAPLAVGSGVAAPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GDL9</accession>
    <name>A0A6P7GDL9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114338188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114338188</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144577.1">
        <property type="nucleotide sequence ID" value="XM_028288776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GDL9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288776.2">
        <property type="protein sequence ID" value="XP_028144577.1"/>
        <property type="gene ID" value="LOC114338188"/>
    </dbReference>
    <dbReference type="GeneID" id="114338188"/>
    <dbReference type="KEGG" id="dvv:114338188"/>
    <dbReference type="InParanoid" id="A0A6P7GDL9"/>
    <dbReference type="OrthoDB" id="6683964at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028144577.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18238" checksum="CB703100160D834F" modified="2020-12-02" version="1">MLIQLSGCFEILAKFNAKNFENFKYTRMQFYRKLSLQKYDASKEIIVQNNNNYQRVITPQSAYRSSKFQQKGIILTCRQKKIKYFRHKELCFLAWAVTHLIYWLYDLQIIPFGSLLSIEPPPWTFQQPLKKPEARNYIIEPDWSSAPTKSICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GI42</accession>
    <name>A0A6P7GI42_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114338426 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114338426</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028144828.1">
        <property type="nucleotide sequence ID" value="XM_028289027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GI42"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656370.1">
        <property type="protein sequence ID" value="XP_050512327.1"/>
        <property type="gene ID" value="LOC126888265"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GI42"/>
    <dbReference type="OrthoDB" id="6049566at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028144828.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39747" checksum="D96C45116BB68F36" modified="2020-12-02" version="1">MESVYPAGMLDRDQRTAKIRLCQCRCSDMEVPNRTSSFTSDASTKISSIFSSIVFNKKRTKFSYLIWKKGYLIHTYNFPRVKNVVLVLVYLTLTMMNSASTAPAPKDDKWWESPCGSSPEPAEPLSTTPPQEFNKWHLSDLLIQAQYNLIQANHLKDSFIFSTVTEGFGRPAITTGEPEYPWLTKSLNIREIQAIHTGKEIMRDLFRSAQAIGYALHIIKDFLGYDRDAAKLKDDLDYVRNLHKSLLTDMCEYMDEREMEPYPYEQIIEPLGMHKNHFQKHTWARNVIANCVEFYLFLWEYLNYHQKTCWEVHRAEKRSNIPEEDFEDDITQKVKKLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIY0</accession>
    <name>A0A6P7GIY0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114339446</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145907.1">
        <property type="nucleotide sequence ID" value="XM_028290106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIY0"/>
    <dbReference type="FunCoup" id="A0A6P7GIY0">
        <property type="interactions" value="1483"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290106.2">
        <property type="protein sequence ID" value="XP_028145907.1"/>
        <property type="gene ID" value="LOC114339446"/>
    </dbReference>
    <dbReference type="GeneID" id="114339446"/>
    <dbReference type="KEGG" id="dvv:114339446"/>
    <dbReference type="CTD" id="33645"/>
    <dbReference type="InParanoid" id="A0A6P7GIY0"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028145907.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16754" checksum="44F266F3829B0EB8" modified="2020-12-02" version="1">MSYMLAHLHNGWQVDQAILSEEDRVVVIRFGHDWDPSCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWPLEDKQEMIDIVETVYRGARKGRGLVVSPKDYSTKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKB2</accession>
    <name>A0A6P7GKB2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC114343710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114343710</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150351.1">
        <property type="nucleotide sequence ID" value="XM_028294550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKB2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028294550.2">
        <property type="protein sequence ID" value="XP_028150351.1"/>
        <property type="gene ID" value="LOC114343710"/>
    </dbReference>
    <dbReference type="GeneID" id="114343710"/>
    <dbReference type="KEGG" id="dvv:114343710"/>
    <dbReference type="InParanoid" id="A0A6P7GKB2"/>
    <dbReference type="OrthoDB" id="4752984at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="358"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028150351.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46995" checksum="D11CC5346836A164" modified="2020-12-02" version="1">MGMITRVRGRLRSLHTLPKLDPEERDEKIAETVCLLSVLFLLPYCSRGHSPLLLSLGGWCLASYSCLVLPVLISANYKYPVRWLRQLGNKVTDLFMRYYEPVCYVLYKIYEPLDRCEKVFMKMSNICNLTIQLIFFMMCDRVLLCNFGGTHCPQKKITGLYSLMFYNVIAYCTSYIKELIEKEDWSVTVRMTQHSNIKHVAMSATKIVLEWTKAVTFVITVTFMLLVFGLEQGLEHYQPTALYTFVTWSYYMCTEKVFVDLFLPMLLWLKLKSLEALEPLYAPVILRYYTISLAAIICIFLSFHGQLRFTLLAFYLTVFLRVKDMVMNCLKQLKHEQAVLGQFRHATEDEIKNCDDVCAVCLSPMERARITPCHHMFHATCLRQCLNNSTICPICKREYTFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMT1</accession>
    <name>A0A6P7GMT1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger and BTB domain-containing protein 41-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114340716</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147287.1">
        <property type="nucleotide sequence ID" value="XM_028291486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMT1"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649782.1">
        <property type="protein sequence ID" value="XP_050505739.1"/>
        <property type="gene ID" value="LOC126884004"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GMT1"/>
    <dbReference type="OrthoDB" id="6782111at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028147287.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="25618" checksum="15D5A96B8862CFB2" modified="2020-12-02" version="1">MDSKDLIKGWKKCEICNKTFVSMSNFRTHIKLKHPDDVEKLDPGAKPSAKCNVCNKSIDKRYMTKHLKLKHPELEETLPSTSKKIYDCTLCHKKFDTLQASLKHNHKRLKMLRCSLCEYENPSQEKLISHMKMLHSIDINSQNLTFDSVEKFEQWKAELEKSTVSKYNITHGSYVTQKYKRSQYNLFVKCIHYVFLINIKYNIFILFINIVCTVTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNM8</accession>
    <name>A0A6P7GNM8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-27 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114340265</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146788.1">
        <property type="nucleotide sequence ID" value="XM_028290987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNM8"/>
    <dbReference type="FunCoup" id="A0A6P7GNM8">
        <property type="interactions" value="1360"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643208.1">
        <property type="protein sequence ID" value="XP_050499165.1"/>
        <property type="gene ID" value="LOC126879880"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNM8"/>
    <dbReference type="OrthoDB" id="10036828at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000210">
        <property type="entry name" value="Putative Sorting nexin-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF19">
        <property type="entry name" value="SORTING NEXIN-27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="113"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028146788.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="58173" checksum="97EE4C3D88ABA283" modified="2020-12-02" version="1">MADLDAAVNNRNRIENMKGSNGPRVVTINKTETGFGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLDRGAAEQAGIRKGDRILEVNGVNVEGATHKQVVDLIKSGGDVLTLTVISVTQQEAERLEPTDDNQVYYDYSEKRSLPISIPDYHHNERSGERYVSFNIYMAGRHLCSRRYREFAKLHNDLKKEFLGFTFPKLPGKWPFTMSEQQLDARRRGLEQYLERVCAVRVIAESDIMQEFLTDQDDENSTSPVDLKVLLPDREVVTVSLKKTSNADEVYDAVIRKIGMSKKVSCYFYLFEIVEYNFERKLQPNEYPHNLYIQNYSTATSTCLSIRRWLFSVDKEYTLMSDAQAISYIFWQAVDEVNRGCIHAGERLYQLKALQDKTRAAEYLKLARELPGYGEVVFPHCACDSRKDGHVVLSIGTMGIKLHACREDGTLESQVILLQWDSLRQWEIDEEGMAFCLKYNRPDKTPKWLKIFTPYYLYLMDCFERIMEESKWLDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H1R3</accession>
    <name>A0A6P7H1R3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transcription factor Sp7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114345022</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151643.1">
        <property type="nucleotide sequence ID" value="XM_028295842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H1R3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645844.1">
        <property type="protein sequence ID" value="XP_050501801.1"/>
        <property type="gene ID" value="LOC126881528"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H1R3"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF165">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028151643.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37241" checksum="B34ADE2600E76951" modified="2020-12-02" version="1">MMASSVPLHQYHQGGTAQPHQINPLNLLAATCNRIYTHQTYPHTQLSPASTTSCSSDGYVSQIPMEPSRSPLEYSPHYQPSYTHAYSNQYWFQHSPPHGDIATSGYQPNHQSINQQYQWPPQTNYMPFTSKMMVKPEIGFSSKARRCIKCQCPNCINEENGLKKPSAKKVHICHYPGCDKVYGKTSHLQAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACSICSKRFMRSDHLTKHVKTHKNGTSPTTKKGEKESSKEETELKSEPEPQFKLQSVSSVPPVQISHYEAQVVHHPMPPSYSNNMYLHNYNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H452</accession>
    <name>A0A6P7H452_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCHC-type zinc finger protein CG3800-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114344131</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150785.1">
        <property type="nucleotide sequence ID" value="XM_028294984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H452"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644409.1">
        <property type="protein sequence ID" value="XP_050500366.1"/>
        <property type="gene ID" value="LOC126880513"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H452"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000075">
        <property type="entry name" value="CCHC-type zinc finger protein CG3800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028150785.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16837" checksum="A53CFEF844DC249C" modified="2020-12-02" version="1">MSSGSICYKCNQPGHFARECSQPGGGRDSGRGSFSRSRDKCHKCNKMGHYARDCKEEAARCYRCYGEGHFAKDCMQSPDMPSCYNCRKPGHIARSCPEAGGDRSSGNDTCHNCQRPGHISRNCPESTKTCYLCHKPGHLKRDCRENDYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H4U4</accession>
    <name>A0A6P7H4U4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial-processing peptidase subunit beta</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114344390</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028151020.1">
        <property type="nucleotide sequence ID" value="XM_028295219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H4U4"/>
    <dbReference type="FunCoup" id="A0A6P7H4U4">
        <property type="interactions" value="2281"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646688.1">
        <property type="protein sequence ID" value="XP_050502645.1"/>
        <property type="gene ID" value="LOC126881946"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H4U4"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="210"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028151020.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53044" checksum="957FADAB824F2E14" modified="2020-12-02" version="1">MASILKFSRSFAKLPKYETALKACRQNIIRGAATQPDSQTVVLNVPPTKVSTLKNGIRVATEDWGSQTATVGIWIDAGSRYEDDKNNGVAHFMEHMAFKGTSKRTQSQLEIEIEDLGAQLNAYTSREQTVYYSKCLAKDVPKAIEILADIIQNAKLGEAEIERERGVILREMQEVESNLQEVVFDHLHAIAYQGTPLANTILGPTANIRSINSTDLRNYLDNHYKSSRIVVAGAGGIEHQDLVKLAESHLGSLNNTYPGKVPVIAPCRFTGSEIRVRDDSLPLAHIALAVEGAGWSDPDTLTLMVASTLLGAWDRSQASAKQNATNLARASGEGDLCHSYQSFNTCYKDTGLWGVYFVSDPLKIEDMVFNIQQEFMRLCTSVTEGEVERAKALLTANTLLQLDTTSAVCEDIGRQLLCYGRRLPPHELAHRINSITAKNVKDVCYKYLYDRCPAVAGVGPVEQLPDYNIVRSQMYWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H6D2</accession>
    <name>A0A6P7H6D2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adult-specific cuticular protein ACP-20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114347644</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154122.1">
        <property type="nucleotide sequence ID" value="XM_028298321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H6D2"/>
    <dbReference type="FunCoup" id="A0A6P7H6D2">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658610.1">
        <property type="protein sequence ID" value="XP_050514567.1"/>
        <property type="gene ID" value="LOC126889895"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H6D2"/>
    <dbReference type="OrthoDB" id="6348134at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028080581" evidence="3">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028154122.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="15788" checksum="51FD4C42F51D30C4" modified="2020-12-02" version="1">MFVKILSVSAILAAAQAGYLGGHGATSYASNQLSAGHGYAVPAAHYGGGGYGGGGYGHDSHQDYYAHPKYQFQYGVQDPHTGDHKSQQEVRDGDVVKGSYTVAEPDGTIRTVHYTADDHNGFNAVVEKSGHAVHPQVYAHGGHGGYDGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAS3</accession>
    <name>A0ABM5IAS3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128763.2">
        <property type="nucleotide sequence ID" value="XM_028272962.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272962.2">
        <property type="protein sequence ID" value="XP_028128763.2"/>
        <property type="gene ID" value="LOC114325040"/>
    </dbReference>
    <dbReference type="GeneID" id="114325040"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128763.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25187" checksum="2D5AF8F81014419A" modified="2025-10-08" version="1">MDQKKRLLKVTEKQKKVLVEYIKTKPQLSSGRFSQDFSQKDSEQLWEDLTNTLNSMGGAIKPWQSWRKCWQDIRSRTKVKMGNIKKHQNKTGGGPPIPPEDNLTSTEEDVYSIIKEVSVEGHTVEESMVSFDFNSSTTNMLSETLNSQIDVQDGSNENNQSLDTEPNLEITNEDPQDIKLQTPQKNENRNHRSTMRSKKRIPKKKRKFYECICCCNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IFS1</accession>
    <name>A0ABM5IFS1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131763.2">
        <property type="nucleotide sequence ID" value="XM_028275962.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275962.2">
        <property type="protein sequence ID" value="XP_028131763.2"/>
        <property type="gene ID" value="LOC114327368"/>
    </dbReference>
    <dbReference type="GeneID" id="114327368"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131763.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="428" mass="47480" checksum="0DC5357958DC7905" modified="2025-10-08" version="1">MTSVTVVLDKEKKHQYKDYVNFLGNYKNGKKSESDTNSSLNSSVSDLNELNEMPTKSFNEYLKDYNTKKFQPVQPAFIKKEEAPKNVKTEVFIQINNTKNTNNSQIQVTLPKPKLDETDGEQIKISVGELSQKFCNTSVHNNKTQTHILKRSSSITEKTKIFEENHDENKKVITKINKVNHIEKFPKKVQAATKKPNQTFIEIRKQELQNSPKINDSVSPPPGKIDVAKFSSQLEHTINNNSTVPVKHSQEEVCSEVPIEPITVDAQESIIKVEIPVSNSAIPPPPPPPLPPANLPPRPVVTSPKVSNSSPKTFHQVPKAPVSNGYSTLPRTGNKTLPRTPNHANDGSLDRNDPRVKKLVYGALQGMYGAYHDKANDYLATLPKNRVKKGNGLDSIINSIAAQGGLDKLCGRAIPKSETESVEANILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGE1</accession>
    <name>A0ABM5IGE1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028132186.2">
        <property type="nucleotide sequence ID" value="XM_028276385.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276385.2">
        <property type="protein sequence ID" value="XP_028132186.2"/>
        <property type="gene ID" value="LOC114327696"/>
    </dbReference>
    <dbReference type="GeneID" id="114327696"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="508"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132186.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="673" mass="78485" checksum="6FFD47613D9ACDC9" modified="2025-10-08" version="1">MAFILSDSHPLGKVKHYFVRREYQGRGLQHFHCMIWVEGAPIIGKFTDDEIANFISKYISCTIPEKTAFPTLFKKVITYQKHKHSKYCQRFKQSKDKKKKFSVCRFGFGRKITPNFILHSVAESILGRRKLRKTRLYDLPRTTEEANINDYNPACLLAWCGNMDIQFIGEASEVLQQYILKYALKSEKSNTGDFREFLQNRSAASNLWSLGMQALSNRECGALEAADTLLQLPLFETDRQTVIRWVDVSMNRARKVKTKQQLDNMHDDADNIFCPNWVDVYYPQRPEEIKNICLYDFVRWYDLINNKPKSETVQYFIYGERYLRLRQHPYLINHYKYNVKKEPESYYHSLLLLFKPWKNHGELMYGMDTYRDAFLSCADELEHMHKYHENLQQIVRAREEVEKEVANLIENEENSININRNENENEHEIVGFEVQIGNELEEIDTRVQKLNDMPIEDQINQLNIDQKRIFDEVVRYVTRYCTEWDAAAKANASNLKDPRLIPNNVMRKFVSGVGGTGKSFLINILRRHIPNLTKKKVVVAAPTGIAALNVNGLTLHRLLQLPIEHEGKCKYRPLSNDKLANIRYDLKDVALLIIDEISMVSNICFACCNIRLCEIFNTIQEEDGYFGKINILLFGDLLQLQPVGEASFAGIPTAIRIIWFISSRKFVDKIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJY2</accession>
    <name>A0ABM5IJY2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7802 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134554.2">
        <property type="nucleotide sequence ID" value="XM_028278753.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278753.2">
        <property type="protein sequence ID" value="XP_028134554.2"/>
        <property type="gene ID" value="LOC114329584"/>
    </dbReference>
    <dbReference type="GeneID" id="114329584"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056704">
        <property type="entry name" value="DUF7802"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982">
        <property type="entry name" value="AGAP005361-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35982:SF1">
        <property type="entry name" value="SPIROCYCLASE, AVEC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25085">
        <property type="entry name" value="DUF7802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7802" evidence="2">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134554.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="436" mass="50922" checksum="B914BA129F58BFC9" modified="2025-10-08" version="1">MDDKMVFRTGIELSEVKYNGFWDWFVHVSDVQTLWKLQPTYLIVQAVYCLGALLTLIHALINKGRLPYLWIGVLLHGIYVEVITYFLPDIDNFWHSQTPIIFVGRRLPLHIMLLYPCFIYNAQIAAAKLKLPKWSEPFLVGLLVVLIDLPYDIVSVKYVHWTWHDTDPNLFDRHYWVPWNSYFFHTTFAAGFTFWFHFLREKICNSGDRWVADKSVFKELVCTILPAVLGFPTGIIGFILIYHPLHDLYNIHSEITYIILFVICLLLSWTGERVTAQREGANNVVGKLHWSSYLTLFHLVVHYATFMLMLIFFNPEDEVSTGMKEPIGPCDEYSPLQTVFGMTLQKRKWLCPTDYDEDYFDFHCLPNKNKFPSNGSIWYTICGTPFENRAEYITIIGLICLMAVGVFGNLYFRSYGDTVFAKKVVKDKSEMKKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILD3</accession>
    <name>A0ABM5ILD3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Claspin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028135619.2">
        <property type="nucleotide sequence ID" value="XM_028279818.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279818.2">
        <property type="protein sequence ID" value="XP_028135619.2"/>
        <property type="gene ID" value="LOC114330470"/>
    </dbReference>
    <dbReference type="GeneID" id="114330470"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1284"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1616"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="906"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1133"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1289"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135619.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1636" mass="185659" checksum="9C79D5032F5F5A02" modified="2025-10-08" version="1">MEVLPNSSDEANSISQENNNDFKSTPQQGVNNGEIEESNNLEIVTSAFNNEINTRNSHEITNTESISNVTLDTSTTFSGHKKNISLETEISSQTDVNKNKPLSISDNESSGTEDNIINKRHKKKLNQLFHSTDSEDEIGARRRHNKLQISDKEASEIDDGIIKIKVFKKKGKKELFDSEESEDEAVNFKIINKSNLKKHLTVSDSESLSSDSSGSLKKNRKGKTNSQDKAAKNMNTKFSANKIRKRITLLESDSENELPTSQEHLIDNFSSNQETMNRFADSDDENILEENSNLKNANTKHISNNVGLESSDSEAEQVTPHNKSFSDAPLEETPIYAVNSKGDLVREQPAKKSNNWTALCDSESSADEDNDEDKPKCDEDDSMSEEDVIKPVKYKKKSMPKEEGEPKKMSGKEAAELRKEIQSESQRMKRESNISLPYHRPKSFTLKEFLSRRPKLASAVPMAAKTPPSVAIKMSIEQLKVVSKNLQKRHKEVEEFYKSDSEEETEDDKDSDYVPPQSELDQVSCSKEDSEEVTDKDSLMPEDFENKVISENGENAGTTIDKCVITNMEVDDSTNAQSILTDDDVLNTDQSQVSYINNTTDKIGKEFEEKASSNNLSKDGDRENSADKTIEDNCDKTGDKLVENIDTLDLQSSMEYEFNLDDMEDNTENIVNVGGKEVHPQISDNEQHSDSMTEDQQKAYFAELDKEIENFGMETSTMEPEKPLKSKLELLKERLANTKPRLSNTSNNVIDLDTVAKPTEVTKLMERFAKHTAKKHIHKDKVKLNVISVESGGEIHKETVAIHVDDDEDTAIEEKPGVRLQKLRNELQSQIAQQRYQHWQNKSTKEVINDTEDPYKDEKSECGADDAILDDDEEEEMSESSEDEIDDENDERENEFETQQKKSAFIDDEADESDIEDATVTATDDDPQEDGDISEYNSNDEEEQEEDEDEKSDKENEQPNEVNEKGILQSKNDKEEVTPFKKPLRRILKAFTEDSDEDEDAELASTINNISDKLNKSNEDSNLTQDDYIPPYQPQNQETPIGHNFRERCNSDLKFCTPVSYITGLQNLTHSASKLQSPLNIPSPLKEADWHTTLQKKLFADSVITDSQAEAMDQLCSEKFPASLDVQEDSNEEVSKDNAEKQNDSEDMPSSIQPTTQDLLNTPSGDFQDLPSTQDLLNICSGEFTGISQVFNVEPSKNLVTHKLDVAIGEDKNLGEDQDMIISQLINEEELEAFKRKFDSPVMTHSQKFVQFPMEEEITATGGVIDSDEDDNILEVKKRKKNQKKLTFSDDESSEDEKEEEEEIDLHDDIEEDDDDAVADINYDSEENEVEYTEENGSKPLKMADFFEDEAELSESEWGSEDEDEKDLDTLEAETGDNEKIDEKQMKADLERIHLRRMLDDDTKEVKLLQEMLLDDGELHGTGRERQFRWKNIDSLDMTEEEKKNSDDETGIDEDESEEMWRRKRHEREMFLKEKQSQDFEDDDFDLLSGSEILKIGHKVMQKSLSSNLQGNQSTEKGFANGNSPIVKTAFSLVHKRGSFLSRGDEVLQRLAEYNKISTTSEVVTQKTKNSKNFLFQTVEVREATEKLTIFNKRKATDATPRAIKKLRLTDNLSPAINRKKKPSKPDVKAKLFGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPJ5</accession>
    <name>A0ABM5IPJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homologous recombination OB-fold protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138174.2">
        <property type="nucleotide sequence ID" value="XM_028282373.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282373.2">
        <property type="protein sequence ID" value="XP_028138174.2"/>
        <property type="gene ID" value="LOC114332547"/>
    </dbReference>
    <dbReference type="GeneID" id="114332547"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058570">
        <property type="entry name" value="HROB_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523:SF1">
        <property type="entry name" value="HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14523">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous recombination OB-fold protein OB-fold" evidence="1">
        <location>
            <begin position="164"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138174.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="436" mass="49358" checksum="338980CD8979615A" modified="2025-10-08" version="1">MFESGTSFGDDDLELETSFTPIFSSTQNKLNEKRKNEVFAEKNSKKVKTHHNTAASFIKNPALAKATKENSFSPNKVVKRMFPGPAGLLPDDIGKKTMITSRSSNDDSEEFFFCSQRSVSTFTEGPWKLMTEDFSSCNDEQLYNKFTISWIKKKYCQKRVLDNYKAPFLAAIIQNLEIVDGKNPSVHITLKDTTGTIDGVIIHRFYKDHSKYFTTGSVVVLKQFGVLNSNERHCITITSKNVLVIYHIRDPNKEDADNTEIKEPFEKVVLQHYNIEDIWKEANSNVAKVSKNNKNLLKNINNTPYGKNKSSSHNISRGINISPQNNASLSNMRHNIQQSSCSNFLLPNINHISTHNQNRNNMPENFSLEKGIAQHESKKKFDFKKVGTDVSPTKPTNAENVVISCSEMSVTADKKDSEIWKSVLEDVDSESLFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IQ76</accession>
    <name>A0ABM5IQ76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138644.2">
        <property type="nucleotide sequence ID" value="XM_028282843.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505052.1">
        <property type="nucleotide sequence ID" value="XM_050649095.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282843.2">
        <property type="protein sequence ID" value="XP_028138644.2"/>
        <property type="gene ID" value="LOC114333028"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649095.1">
        <property type="protein sequence ID" value="XP_050505052.1"/>
        <property type="gene ID" value="LOC114333028"/>
    </dbReference>
    <dbReference type="GeneID" id="114333028"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="672" mass="77565" checksum="B3636F1CABE5EB4D" modified="2025-10-08" version="1">MEGRKQPGSFWHKRKQEKQERQNKILKGIPKMTAFFTPDGNQEDDTTNISQPCSSSSATSDKYIHIQPHELILETSELVPEPEHLVSPVSKVLEYEEATTSNSDPKQDLLNFKDPALWQDSHNYAEIILEKWVEQNLTDMDFSMSKRNFGEQHRYAGKQIFYKRLVNGEVVRRDWAIYSESTGNIFCLYCVLFGNKKNQFKTGFSLWNKSKERLDEHERSNDHIDNLKMYMTRLLKQGRVDVELEKEISTAKEYWMKVLERIISVIKFLATRELAFRGTHERISEKRNGDYLGLLKLLSEYDPFLKDHINKRANLGKGKTSYLSKVICNELLNILSNRVNDEIVRQIKANKYYSISVDSTPDITHHDQLTVILKYCDNKGNPVERLVGFYKNTGHSSQQFEETVIGMLESLKLDIKNCRGQSYDNASNMSGKYSGLQERIKAYNDLAIFVPCAAHSLNLVVQNAADCCLEATFFFMLVQAIYNFFSVSTHRWELLSRAIKDSAESGQTLLPKRVNTTRWSSRFDAVKALKSNYGLIKTCLIGISTDINEKNIVRVEAASLSEKLDLLENGIILSFWLDVLQRVNEVNKSVQKENMDLSTTAHLLSSLADYFDFLRDRFDHYEVLGMLLTGNENYAEKRIIKKIAIRRNEFGGKLKPKRKNANTMLCLYNRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXP8</accession>
    <name>A0ABM5IXP8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147501.2">
        <property type="nucleotide sequence ID" value="XM_028291700.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291700.2">
        <property type="protein sequence ID" value="XP_028147501.2"/>
        <property type="gene ID" value="LOC114340923"/>
    </dbReference>
    <dbReference type="GeneID" id="114340923"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047395894" evidence="1">
        <location>
            <begin position="31"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="577" mass="59114" checksum="C1B3087B4C0423D0" modified="2025-10-08" version="1">MVGEEASGGCEGKNMKAFLVFVACLGLAVASTADAKNKKVEVEEKKISKRHHDHYSTLNTYGGDLASQSLSSYGGDLSSHSSGLSGYGSGLSGYSSGVSGYDSGLSGYSSEGGYSSGSSSEYSSGSQGYGSDFSGYSSGSHGYGGDLSGYSSGSHGYGGDLSSYSSGSYGYGGDASGYSSGLNGGLLGDSGSVSYGYHSVAPVVHNVHSTHEVRRITQKVPVPVPQPYPVTVTKTVQVPQPVPVEVPKPYPVPVKVPVPYEVPKPYEVKVPQPVAVPVKVHVPVEVPKPYPVHITKTIPVPVEKKIYIKQLVQVPHPVPQPYPVTVTKYEQVKVPTPVYVKERKVVHTYSNSYQNLPEKHIVLKPQVSAQVPQYSNAGYDASSYSSSLGSYGSGYGSNYGSSYGSGYGYGGHGSSSYNLGSYGDSYNSGVSGLGYNNLGGSSSSGLGYGSYGGSSSSGLGYGSLGGSSSSGLGYGSYGGSSSSGLGYGSLGGSSGSYSSWGSSSLSGLGGSSGHLGGHGSSGHGLYGHGSHSYGLGDSSSQYSHSYGHSQAFGHGDDYSGLLKSYVPSKLGGYNNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZL1</accession>
    <name>A0ABM5IZL1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028153019.2">
        <property type="nucleotide sequence ID" value="XM_028297218.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028297218.2">
        <property type="protein sequence ID" value="XP_028153019.2"/>
        <property type="gene ID" value="LOC114346480"/>
    </dbReference>
    <dbReference type="GeneID" id="114346480"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="447"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028153019.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="876" mass="99957" checksum="0D2D3EB9C70475C4" modified="2025-10-08" version="1">MSDRPEESPMPTPRSNVSSPGPDLAPFEDEGALLGDINSDIEEEDGEELFGDNMENDYRAMPHLDRYDDRVLDEDDYDQMSVGERLAAEEELRRRDRELGIIRRDDRELFYDQDDDEEDPRQRRRKEAEKAAAGEEADAEMIESIENLEDTKGYTIKEWVVMIGPRTEIANRFKNFLRTCTNSKGQYVYKDKIRRMCENNQSSFNVEFPSLAHKEHVLAYFLPEAPFQMIEVFDEVAKDIVLSMYPSYDRVTNEIHVRISDLPLIEELRTFRKLHVNQLVRTLGVVTATTGVLPQLSVVKFDCGKCGFILGPFTQTQESEVQPNACPQCQSHGPFMINMEQTVYRNYQKITLQESPGRIPAGRVPRSKDCILLADLCDRCKPGDEVDITGIYTNSYDGSLNTDNGFPVFSTVILANYLIVKDCKQIVQSLTDDDINSIIKMSKDHRVAERILTSIAPSIYGHDFIKRALAMALFGGESKNPGDKHKVRGDINVLICGDPGTAKSQFLKFVEKIAPRAVFTTGQGASAVGLTAYVRRDAATREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYDASMTFAENVNLSDPILSRFDILCVVRDEVDPIQDQHLAKFVVGSHIRHHPSKKDQELPEEPQNDMQIPQEMLKKYIVYARQNIHPKLQNMDQDKVANIYSQLRQESLATGSLPITVRHIESIIRMSEAHAKMHLREYVQEDDVNMAVRMMLESFVETQKYSVMKSMRQVFQRYLLFKKDHSELLFYILRQLAQDQLTFQRNTTEMEALTIEIDEKDLMDKAKQIDIHDLKPFYQSQIFESNNFVYDAKRKVIIHTVPESMITED</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J075</accession>
    <name>A0ABM5J075_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028155478.2">
        <property type="nucleotide sequence ID" value="XM_028299677.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299677.2">
        <property type="protein sequence ID" value="XP_028155478.2"/>
        <property type="gene ID" value="LOC114349337"/>
    </dbReference>
    <dbReference type="GeneID" id="114349337"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155478.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="222" mass="26147" checksum="4CCBF23EB011F7AE" modified="2025-10-08" version="1">MDIDDYKLVDLVKRCNVIYDKNHGQHKNKFAKFEAFKQIAATLNSSAELCESRWCLLRNRFCLELRHIRTADPSAVPRRPWPLFQHMRFLSKFIYPRKTRTMLLSGYKPSNFQSQMKSESDYSFNSEIKEESEDFELNFKDPPEEIETTPSLSISDSMDYLKDNNSEEDIHVPVATMMDEEDEDTFFGKMIAKYLKRVKDVDKKIQIKIEMMKVLKTSLDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JIZ9</accession>
    <name>A0ABM5JIZ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein DDB_G0290503</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497913.1">
        <property type="nucleotide sequence ID" value="XM_050641956.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641956.1">
        <property type="protein sequence ID" value="XP_050497913.1"/>
        <property type="gene ID" value="LOC126879063"/>
    </dbReference>
    <dbReference type="GeneID" id="126879063"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24664">
        <property type="entry name" value="Monjiviricetes_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046489964" description="Leucine-rich repeat-containing protein DDB_G0290503" evidence="2">
        <location>
            <begin position="19"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="705"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="89770" checksum="96C6F2F19D5988DE" modified="2025-10-08" version="1">MKSLLFLLLFYSWQISFAQKCSSPQVSRKLSFIYRTVPSSKIELIECFYTDGNPKNNYYDITKNCVTAAKTKIFIDKYGDDHRVNVRGSKVTLKTYYADADTSQNVVFLKSGKKCRYDAGFCYDSSQGNNYAVVWAVNPVPKIVCPNQLQQIFYGYVDYWTFTTENRKYLIYSVPLKDESFSLSLSNATVCHGKQAWYVDEQGFLVSFTSLLPRITSTPNLDRKLFPPFKSKGDISDSIIRDCTLKSYNLNFDTKIDTDYLSDSENLKIILKFYQQNIDNNKNAINKLATDLQKNNGVKGPSSNVLSELNKIKSSINSNFNSINKLFKDINQLKIVDTDIYSIITNLANSVKQLKIDIKNINKNDENLEKYLKEFKNDVYKKLNNYNTDIKKELDKVKQSSGSNVINTLNPTIQSLNHSSTTCINKVNSLKKDTEMSIQQLQKNLMITQDSLETNVKKFILANLTNIEMVFGRKLNDVLASANKKCDKSLNDVTAFKNMLKNDLAMLEGKLDKCSTDQKTTSDELNKAERALSTRISSSANDIKQLKDSLYNYVNMSISSLTNANNKDFSKELGDLKRSLSGRLSNDESRLSDVEKNVQKLRSDFNQKSNSLDATIQGIRKDILVLQGPNDELALTVEAGVLAKVIPLLNPTLITKNVSRELDVLKDEVAAQFANSSKTIKDLKTEVDSCKRVSGTKFKENEKKIGQIENNLSSTQMNLNDLSEKLNNGVLNEVNTRVTSALNKSAKCETKVKQLQDEINKLRNDFETTVAMLREEHKEFRKKLEAEDVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPL4</accession>
    <name>A0ABM5JPL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial glutamate carrier 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050499881.1">
        <property type="nucleotide sequence ID" value="XM_050643924.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643924.1">
        <property type="protein sequence ID" value="XP_050499881.1"/>
        <property type="gene ID" value="LOC114324358"/>
    </dbReference>
    <dbReference type="GeneID" id="114324358"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="105"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35164" checksum="C98A1B73F8F54A9E" modified="2025-10-08" version="1">MAEKQATFSIIPKIINGGIAGLIGVTCVFPIDLVKTRLQNQQIGPQGEKMYANILDAFKKTFKTEGFFALYRGAGVNLLLITPEKALKLAANDFFRYHLSTGGVLPVYKQVIAGGLAGLCQLIITTPMELLKIQMQDAGRVEAATKMGSQGQQIKEKLTATKLALNIIKTDGIFGFYKGTGATALRDVSFSMVYFPLFFALNELGPKRADSDTIFWATFFAGLGAGGVSALSVTPFDVVKTRLQTAKKAAGEDFYTGIPDAFRRIFLKEGPKAFFKGGFCRILVIAPLFGIAQMVYFLGIAEWLLGVDKYAILREEHKSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPV6</accession>
    <name>A0ABM5JPV6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499971.1">
        <property type="nucleotide sequence ID" value="XM_050644014.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644014.1">
        <property type="protein sequence ID" value="XP_050499971.1"/>
        <property type="gene ID" value="LOC126880241"/>
    </dbReference>
    <dbReference type="GeneID" id="126880241"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13707" checksum="B8E3970AC44B9E3C" modified="2025-10-08" version="1">MLIMFMRSYLRNMADQSELRSNELLLPLQTKQAAIALGKLMFFSVLMFTLPFVAFFGTKYILQEHFDVIGFTNTVWSVLFSVVTVNLIIVAYAYIAYLEPDYDEKGNVKEESRNKKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQN9</accession>
    <name>A0ABM5JQN9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Intersectin-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050500253.1">
        <property type="nucleotide sequence ID" value="XM_050644296.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500254.1">
        <property type="nucleotide sequence ID" value="XM_050644297.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644296.1">
        <property type="protein sequence ID" value="XP_050500253.1"/>
        <property type="gene ID" value="LOC114330018"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644297.1">
        <property type="protein sequence ID" value="XP_050500254.1"/>
        <property type="gene ID" value="LOC114330018"/>
    </dbReference>
    <dbReference type="GeneID" id="114330018"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11836">
        <property type="entry name" value="SH3_Intersectin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11838">
        <property type="entry name" value="SH3_Intersectin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11839">
        <property type="entry name" value="SH3_Intersectin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="348"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="790"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="913"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="10">
        <location>
            <begin position="1205"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1537"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1710" mass="191210" checksum="7D0A0CA5C992C681" modified="2025-10-08" version="1">MSAAGTPSTDPWVILARERTRYEEQFRSLKPNNGIITGDQAKSFLLQSQLPPIILGQIWALADTDADGKMNIDEFSIACKLINLKLRGYEVPKGLPPSLLASLKVNTPPAIPPLPNTALVNPPSRPEPPKIAPMMSTQPLSQPLTSTQPPLLPGLIGQPPSNITPNTASMGMVQTGIVPPTKGNFTNIPNAPNIPTGIIPPMQSTVPLVQPLIDAAPSMASTAPLVSGIPLSSSTIQPVMSSAPLVSGVPLTASSIAPTIPPISSVLPPNLSGGPGIPPPIPNIPSVPVNTVAPLPAPGMSPITSQPVGVVGRPGATSTPRASITSLERTHSIDSTSSQPEWSVPHQTKLKYTQIFNTTDRTRTGFLSGAQARNVMVQTKLPQNILALIWALSDMDADGRLGCEEFVLAMHLCEQASLGHAPPSRLPPDLIPPSFRRTRTTSISSQGSAPIDQDPASTLLQNSFEDKRKENFEKGQAELERRRKTLLDQQRQEREERERKEREEQEKKEKARQEAERKRLDELEKQMRDQQEKERLIEEEKKRQADQREAARKEMERQRQLEWEKQRLQELHNQRQREQETVLKLKARNQSLTIELTTLNDQVKELSQKICDTRMGVSSVKTTIDGMRSTRDSQMQEMSQLKNKLKEQNAKLLALSQEKIKLDAKNKANTQDTEQARLAFENKEVTIKNLKTKVDDMQVEIDSKMADIENNNTQLKDLQTELKNLVNECEQLYSVYEVKRNTILDMKNSGKPNEMNAWQSTDAWGSNDNETSSDWPVDNWAASTDVSTLPGLVKYRALYEFVARNNDEISFQPGDIINVPKEQTGEPGWLAGEIRGHTGWFPEAYVEPVDGVGVRDDSAFSQTTTSIEETEATRLEGIAEVPEGSETTNSFEPTPVHVPSEVEQPVALVEPEVEPEYYIANYPYQSVEPGDLTFNAGEVIGVIKKEGDWWTGKLGNLVGIFPSNYVQKVDVNSSANTINAAPVAAPPEPTQEPALPPMPPMELSTGVSAEAVESALANVSAQSQADNEVSQISLNKAKEEAYAQAGQVVKTKKPEIASVIAPYQSTSPEQLSLARGQLIMIRKKTDSGWWEGELQAKGRKRQVGWFPASYVKVLNSSGRISGRTTPVSTTRMQQEVIIDKVIALYPYSAGNPDELTFAKDDIISVTAREEEAWWRGELNGVSGLFPSNYVSPLQQSPPLTPQNKKRKESINEFVQTEKSYVHDMSVVHEVFEEPLRKCKLISAKEIDEIFVNWQDIIFCNKLFLKDLLNANKTGSDMIGHIICKHLPEMKAYVTFCGKQLDSAALLQKLTENSTAFRDLVKKCQNNVATKGMPLSSFLIKPMQRITRYPLLINKILENTPDDHPDYKNLQEALILAESFLNSINENVRLKENQDRLNWLQQCVQNDLNIVFNSETNKLGPRQLLHYGIFNKLKSNKELLGFLFNDFFMFVQATKSIGVQFTFQINENVSYKLYKQPILIQNLMVSRDSSDNIESGTDSNRVLNIQDDKNTYKIALLVHTVSECGLWMKRIESAKEMCSKMFTLSLQNKRKTLPHFRNSLIIRKIEGKEIVVKKVNEQRGSLNRKKGKHHTENIYCKVALGTQEQETDVARETYNNGNSVQNGLPHTPSLVWNYSMQFQLRNLNQESLIVTVYKQNHFSPDDFLGRAELRIKEILRDSQNHNGPITKKLILHQVESGEITVKLDLHLFDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQW2</accession>
    <name>A0ABM5JQW2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500331.1">
        <property type="nucleotide sequence ID" value="XM_050644374.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644374.1">
        <property type="protein sequence ID" value="XP_050500331.1"/>
        <property type="gene ID" value="LOC126880496"/>
    </dbReference>
    <dbReference type="GeneID" id="126880496"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="12">
        <location>
            <begin position="515"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="714" mass="80592" checksum="D24A42FA548BFF0B" modified="2025-10-08" version="1">MFFSKSMSLVVYEVKVLFLIVIKINYLMCIQNELVVRVTGGPFVAQLLAEEHGHLYKGPVRGFKDTYILIPLENVYENHQKRGFFPKKIANDQRVLWAEEQHVKLRQKRDFIAEEDIPKERVKRVEDIPSSQRLNSSKLRQKRDVMAEEGIPKQRVKRVQDFQIRERKTLVTASDQTFNDELWSQQWYLRDTRSRLDLPKLDLNVLPVYYMGITGKGIRISILDDGIEYTHDDLRENYDPEISWDCNEDDNDPYPRLDAPKSNNHGTRCAGEVSMMANNRKCGVGIAFGARVGAVKMLDGIITDRIEGTALGYAQHLVDIYSASWGPNDDGKTVDGPGRLAVEAIERGIREGRGGKGVIYVWASGNGGNNNDNCNCDGYLASPYTISIGSASQTGKFPWYGEACASTLAVTYSSGAYKDQMITTTDIKNSCTTKHTGTSASAPLAAGIIALALEVNGNLTWRDVQHLITWTSELAPLTHNPGWQQNSAGFWVSDRFGFGLMNAFGLIREAINWKTVPERKTCRNLLRMNSTLSSSEPVKIEITSTGCKQTDHELKYLEHVEVQTNINYTSRGSLQIKLYSPTGTMVNLLAPRKLDKSSQGFQNWTFMSVMTWGEIAEGIWTIVITDVTSSKKHIGSVGDTMLILHGTRHLPPHMREGPRNYDENYNRLQNRVKLAHAANYETHNLVDRVQNLESRSAYLPQDIMEEILINDLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSH6</accession>
    <name>A0ABM5JSH6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500880.1">
        <property type="nucleotide sequence ID" value="XM_050644923.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644923.1">
        <property type="protein sequence ID" value="XP_050500880.1"/>
        <property type="gene ID" value="LOC126880855"/>
    </dbReference>
    <dbReference type="GeneID" id="126880855"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="312" mass="36144" checksum="9B8CB8323907AA6B" modified="2025-10-08" version="1">MNSKQQLLRQIDREFTLIQKNIEKDEYVVVTLTEIRKGTVMKFVGKIKEQCLEDIHEEAYDITYLRNYRNHQDSFVFPDIPDDNSFWRNEPELWFLRLEAQFRQAKIISDNCKFDHTVASLNSDILIEVADIVKNPTADSAYTQLKARLLERYGISSDKRIYRLMELTLGDLKPTQLLYRMQALATDSISTQVLKNFWLDRVPPSVRSVISVLDGDLEELAKKADRYLRCSSFPVMAVTESPTLDKAVAALNDQVSGLSNRLAVDEERQQIQMVKSTKSSSDEQCYYHRRFGAQAKKCRPPCSFTKNDERAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSR4</accession>
    <name>A0ABM5JSR4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500979.1">
        <property type="nucleotide sequence ID" value="XM_050645022.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645022.1">
        <property type="protein sequence ID" value="XP_050500979.1"/>
        <property type="gene ID" value="LOC126880946"/>
    </dbReference>
    <dbReference type="GeneID" id="126880946"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="153" mass="17387" checksum="41FBF666D3C7DC35" modified="2025-10-08" version="1">MLVHAAGTYATVLRKAPNNFVIIMMPSKKEFCLPAQCMCTVGKLSNVESGSTSIGSAGKNRELGNRSRSGLWQRKKGCHGRKIRRPPPVRTIVDKPIDNVEPIQLTLTRPFIKNLNKFLQGNNTHILQFEDKIMYWVLEEVALIEEKIRRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSS2</accession>
    <name>A0ABM5JSS2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500993.1">
        <property type="nucleotide sequence ID" value="XM_050645036.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645036.1">
        <property type="protein sequence ID" value="XP_050500993.1"/>
        <property type="gene ID" value="LOC126880955"/>
    </dbReference>
    <dbReference type="GeneID" id="126880955"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="326"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="441" mass="50697" checksum="EF52705AA86236C2" modified="2025-10-08" version="1">MAMANTYLDVSSGSTTINMPVQVNPPEKFTFSQPNMWPQWRKRFQRFMSVSGQDQKPEKDKIDILMYIMGDEAEEIVLQFPKIPATYSEMLQSFENHFIPRRNVIFERFKFNSRIQQTGEAIEHFITSLHSLAEYCDYSTLKEELIRDRIVVGMSDTKTSERLQLQGTLTLKDCIIAAKQAEMQANQTRELRNENRYHPTQEVAKVGVQNRERGNVTGSFQKADNIRRKNFQGDTCMFCGQQSHSREVCPARRSQCNKCKKFGHWASVCLSGKGQRENKVSTVEIDNFMMNSEGNNLNFVGSVYINNIEAREWLISVLVFELRTKFEFLIDSGADVSCIPSSLMPKEILKTLCKPYQKVTGPSGIKLEVVGTLPVTLCHNNDISKTQMFVIQNLSKPILGRKSIIDLKLLQFHENVTKKKPGDYDEDMNSDIIEEYFQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWK2</accession>
    <name>A0ABM5JWK2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="53">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="53 54">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="53" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
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            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
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            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
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        <text evidence="1">Lipid metabolism.</text>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="ketoacyl-synt"/>
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        <property type="entry name" value="PKS_ER"/>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="54" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
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            <position position="862"/>
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            <position position="1011"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047961"/>
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    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
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    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="37">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="47">
        <source>
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    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
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    <evidence type="ECO:0000256" key="49">
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    <evidence type="ECO:0000259" key="50">
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        <source>
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    <evidence type="ECO:0000259" key="52">
        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="2334" mass="260430" checksum="2551D4E7D6FCCB07" modified="2025-10-08" version="1">MPILAIMGVENTENLNMDHEDSSDNVDYNSIQAKLFTSVPPEEEIVISGLSGTYPNSTDVYHFQENLFNKVDMISPNRRWTYKHPEVPDRSGTIPCASKYDGGFFGVHHKQGESQDSSGRILLEKTVEAIFDAGMNLEDLEGTNTGVYVGTCTSETEQSVMVQHLGPDPKTGFTGCIRSSLAQRISYFLKLKGPSLIADTACSSSLFALESAYRDLRLGLVDTAVVGGANMTLHPFVSLQFARLGVLSHDGSCKVFDKTGNGYARAETVSVIILQKSKDAKRKYADLVYVKTNCDGYKEAGITYPSGEAQRQLMREVYSDCGISPADLSFIEAHGTGTFVGDPEESGAIDDVLAKCRTDPLLIGSVKSNLGHSEPSSGLCSITKSIIAYETGLIPPNIHFTCPRDEILGLVEKRMIVVTEKTPFKDKRGLIGINNFGFGGGNAHVLLKANPKEKINGGLPKDDIPRVICVSGRTSEALLTIFDEIKSHTLDAEYVRLLHNVFRKPILNHRCRGYSIVAKSGEIYRFTGNSPEKKPQLSFAFGELNEWFELAQCLKLIPAFAVTLEKAHKILLPKGININDALEAHESGSPKYQILGSILVQLGVIDIFKMLEIEPTNCFGFSFGELLAAHFNDILTFKQTLECACIINDVVEKVNGTCKGREINIVNNMVNNHVTSNVSSLLDQFRANFGSVESSSIKIELSANLSHILENPTNGKYKKDFKTADYFIKALVNGISNKLEHTKSNSLVLTFGSITTLDVAPDDVEVIPLVSEHEDNYLTGFLKILGILYVNGNNPQLAKLYPEVSFPVSRGTRMISPFIKWEHTRDWFVPSYDINLNSAVQYGAKSVSVELGDQKWTFVQGHVIDGRNLFPATGYLFLVWDTLCLIEDIPVNLKHIVFEDVKFLRATTVPKTGAVSFKVFLNIISGRFEIVEGGTLIVTGKVYSKDEDDATYCGVDTIAEHANSLTRKDVYKELRLRGYNYSGEFENIQTFNPSDNTGLIKWTDNWISFLDNMLQLKILTTDTRLLYVPTYINRLKLPAKPVMEWINKSYLEKQLEPILPVYINEDTSEIRCGGIVIQGLMASSIARKKDVGIPVLESHIFVPNITELELEESVRVNLQIVYENLLTKKYKCIELIDEFVTQECTLIPLVQTALGDQPLLQAIVKILAKSRPEYVPEEIEVEDKELDAETECHLVIGSKLIGRKDVLKTTTQCLKDNGFLISREDINFDSSISEVEDFTVFTVHNTPLETLVLLKKNFKTKELIAVEIDRSDDLSWIEELKDIIKSKKSDNVLIYAQNKPLSGIMGLFNCLKQEGDSSYIRCLFAFETDQHFGKDDQFYKTQLDKNMAVNIWKDNKWGTYRHLLLKNLDTVESEHCFGNITVRGDLSSLRWIESTYKYDMVVPTEKQLVYIHYASLNFRDVMTASGKINADVITQDRIEQECVQGFEFSGYTATGKRVMGLVTHGAMSTLMLGDDYLLFNVPENISLREAASLPCVYTTVLYGLINRVNMRRGSSILIHSGTGGVGQAAIRVALHYDCNIFVTVGTQEKREYLLKTFPQIKPRQIGNSRDISFETMVKKYTGGRGVDVVLNSLAEEKLQASIRCLAPGGSFVEIGKFDLANNNEINLLLMQKECSFHGVMLDQIFEAPPKIKNDISRLFEENVGKFIVPLPVTCFKYDQLVEAFRYMGSGKHMGKVMIQVREDEQPPQPVPEKFTGIPRYFCYPEKSYIIIGGLGGFGLELADWLVLRGVKNLVLVSRKGVTTGYQSLRVSLWKSYGVHVHISQDDVCTEDGCRNLLESANQLGDVHSIFNLGVVLADSVFENQTPETFKTSFGPKAVATKYLDRISREMCPKLEDFVVFSSVSCGRGNAGQTNYGMANSVMERICELRKKEGYPALAIQWGAIGDVGLVAELQTNHTQLEIGGTLQQKISNCLNVLNTLLRQNQATVVSSIVVAEKLSGAGSSDNIVDTVTNILGLTDMKVVSHHVTLPELGMDSVTGVEIKQTLEREFEIFLTPKDLKTMTLHKLKEIQQTSATPLEYNKFENFNAILFNNFNEDIEDILKEVEVPLPTKAEENGKNDTVLLFPGIDGFARTFNTLASRLTMPVVSYQYWNSVEYPSVQVLAESLLPKVENSIKKNQKFKILAYSFGSAIALEVVHLLENKGYVGEVVIIDGGPSFIKNLVQNFTLLSDSEFQTNLVLYLIGSYVPSDVILKHQEHIMKCSTWNERLDFSLGLLKENNNFSEESIAIKRYLANGMFNKTQLAMHYVQSFTKLKSKITLIVPEESIVQNIEIDRGVSNIAVNEVNIIHAKGNHVSVLETEEIGDVVNSIFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZR5</accession>
    <name>A0ABM5JZR5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503431.1">
        <property type="nucleotide sequence ID" value="XM_050647474.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647474.1">
        <property type="protein sequence ID" value="XP_050503431.1"/>
        <property type="gene ID" value="LOC126882507"/>
    </dbReference>
    <dbReference type="GeneID" id="126882507"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="175"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="299" mass="35416" checksum="25235D10FB0A6DEB" modified="2025-10-08" version="1">MEGKKPVEINEFAKNIIRRKIHGFFFKKEIPNLNKILQEVKDDPDLPNIGRTKLWEVLKELNFRWEKSDRKSVLIDREEIICWRRHYLRSIRKFRAEGRPIYYQDETWVNAGHTLTKIWSDKNILSSRQAFIEGWSTSISPPSGKDSRLIISHLGSEKGFLMDGLLEFQSKSTKDYHEEMTADVFEEYFEQMIEHIPPNSIIVLDNAPYHSRLVERLPTTAWKKQDVLDCLRNKSLTYEDGMVKAELLKIARQHKSKYKKYVVDKMAERRNITVLRLPPYHCEINPIKLIWAQNERLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K047</accession>
    <name>A0ABM5K047_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503561.1">
        <property type="nucleotide sequence ID" value="XM_050647604.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647604.1">
        <property type="protein sequence ID" value="XP_050503561.1"/>
        <property type="gene ID" value="LOC126882629"/>
    </dbReference>
    <dbReference type="GeneID" id="126882629"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="150211" checksum="03CC7E9160E299C8" modified="2025-10-08" version="1">MLTKLIQLIATILGLIQNKYNDEKLRKGLIECRKAIKMIHDRMRFAKTIGEKQHLEAQMRQVRTLSKQLKAEQKKGARLNTRPETAKRRVHWEDSVSTFNSRIQTGVISNLKHKDPGSFLVDCKALFKRRIQTALKNNAAVKVNIAFGGEFEIAQGDKMINETKYFTTSNSAIYRDTNLDEWFEKKVVKPINRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIEVPPQIKIKQACINVKNDDDACFAWAVISALYPCQNNSALMSSYPHYSQVLKLKGIQWPMTAKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTKDKKDKHVNLLLIQDKYDEQGPLKYHYVWIKNLSRLLSKQLSNEDGTKYFCDGCLHYFRSQEKLNVHKTCCKGRSDVLCDRCLQPFLSSTQLEAHINDCERINETAIKMPEESHKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVWYYFKCSYDDSLSFYKSYRGKDCMKWFADELNQLAEDVSTVFMCPFDINMTFQQESDFQAATHCHICEQRFSLSDKKMRDHNHLIPENNYRFASHEGCNINYKDAHTIPVIFHNLSGYDAHFIINDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSQYVFLPEEQFNLLTVKGIMPYDYIDSFDRFIETCLPPIEFFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLADVFERFRSSCLETYNLDPAHYFTLPGFTWDAMLNYTKQELELLTDPDMHLFVERGIRGGLSQVCSKRRVHANNKYMASYDPSKPDSYLMYFDVNNQYGWAMSQYLPYGGFEWSDTNINVLSIPDDSSEGCILEVDLEYPQHLHDRHKDIPFCPQSLNPKTMKPPKRPRELTKLMATLHDKERYIIHYRALKQALAHGLILKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTLEGVRRRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLIAVEMHRAEIWLVKPIYVGMSILDLAKTTIYDFQYGYLASRFGENFSTCYTDTDSVIVEIREKDPYEAMIHDCYKYFDTSDYPKDNIYGIPLVNKKVLGIMKDENNGCIMTDYIGLRSKLYTTKAATTDVDIKKLRGKLKEQEYDDDEVDNIIRNYGVTKKAKGVKKSVVNTKITFEDYVECSDTFTAKVTSQNLIRSDKHKVYSITQSKIALSPNDDKRHHIQGSYDTLPFGHYLIDTLEMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K265</accession>
    <name>A0ABM5K265_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">xanthine dehydrogenase</fullName>
            <ecNumber evidence="6">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050504281.1">
        <property type="nucleotide sequence ID" value="XM_050648324.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648324.1">
        <property type="protein sequence ID" value="XP_050504281.1"/>
        <property type="gene ID" value="LOC114333334"/>
    </dbReference>
    <dbReference type="GeneID" id="114333334"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="21">
        <location>
            <begin position="247"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1348" mass="149362" checksum="09E0FC9C227C468F" modified="2025-10-08" version="1">MVMQVDSNSTLVFYVNGKKIVEENVDPEWTLLYYLRNQLRLCGTKLGCGEGGCGACTVMVSKFDREKNKVVHLPVNACLAPICSMHGLAVTTVEGIGSTKTKLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNSPKPSMKDLEVAFQGNLCRCTGYRPIIEGYKTFTEEWELIQTGNKLNGVNGTNGCGMGDKCCKLQKGINGKHEDDEVLFNPSEFTPYHPSQEPIFPPELKLNDTYDKQNLVFKGANTTWYRPTKLSELLDLKQKFPNAKLVVGNTEVGVEVKFKHMVYPDIIQPVQIPELTSIEQTPKGVKIGASATLVDIENYLQKQINEQQEHKTKIFKAVIQMMNWFAGKQIRSVGALGSNIMTGSPISDMIPILMAAKAKLELFSNDGSRTVTLDNNFFVGYRKSIVKPEEILLSILIPYTQENQYFEAYKQARRREDDIAIVNEAVNVTFKPQTDIIKDISFGIGGMSFKTVSAPKTEAKLIGLSWNKTMLDTAFNSLLEDLPLDAGAPGGMISYRKALPLSLFFKAYLSISQDLQKVLPHIKIDKREISGASGFSTHEYKSSQYFRVVPETQEKTNAVGRPLVHRSGIKQATGEAVYNDDMPRLEGELFAACVLSSKPHAKILNIDESEALAMEGVHGIVSAKDLKKPVLWGSVFHDEEVFYSNTVTAVGQIVGLVVADTQALAQKAAKKVKITYEELQPVIISIEDAIRHQSFFETVTLLEKGDIDNVFRRAPHTLEGECRMGGQEHFYFETQSCIAIPKPEDDELEIFSSTQNPTEVARLVSEVLDIPQHKIVSRVKRLGGGFGGKESKAAMLALPIAVAAKKFNRPIRCMLDRDEDIVMTGARHPFYYKYKVAFDESGKMLGLNAELYANSGYSNDLSFSVMARAVTHAENAYHIPTCKVKGTLCKTNLPSNTAFRGFGAPQGMYMAEVIVQQIADYLQKDPIEISQINLYNEGDATNFNQVLENCTLDKCWRECKESSNYLSRREAVKEFNRLNKYKKRGLNIVPTKYGIAFGVTFLNQAGALVLIYSDGSVLISHGGIEMGQGLYTKMIQVASKALGIPVEKIHTMESSTDKVPNTSPTAASTGSDLNGMAVLNACEILNERLKPYKEANPNGTWEQWVNTAYFDRVSLAVSGFYKTPDLGYDWKTGQGRMYNYFTYGVACSEVEIDTLTGDHQVIRTDIVMDLGESLNPAIDVGQVEGAFMQGYGLFVLEEMMYSPRGETLTRGPGTYKIPGFADIPGEFNVSLLKGVSNPRAVYSSKAVGEPPLFLASSVMFAIKDAIKAAREENNVEPGHFRIDAPYTAAKIRMACMDNITAKIQEPEPGSFKPWNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K281</accession>
    <name>A0ABM5K281_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050504298.1">
        <property type="nucleotide sequence ID" value="XM_050648341.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648341.1">
        <property type="protein sequence ID" value="XP_050504298.1"/>
        <property type="gene ID" value="LOC126883099"/>
    </dbReference>
    <dbReference type="GeneID" id="126883099"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="59"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="494"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="586" mass="66142" checksum="CA5575D6435E2FB7" modified="2025-10-08" version="1">MRRSLCTTVKLTKNVHVRKKGNHQEIRKLSTKPSYYHCVGEDPLSHLTLGQLSEKCSYSFGDRTAVVSCHQKKKLTFRSLLEEADRLAAGFLKLGFQKEDRIGIWAPNLVEWYIAFIACARGGFVMVSMNPFYQANEAENLIKQVKIKGLICGDVFRKQDYYHLLKSICPELEDSKPGKIYSDRVPSLRTVVHITEENKKGTFKFTDIQNMADEDTMLQIKNFQNKIKFDDPCNIQFTSGTTGMPKAPVQSHFNIVNNGYFSGKRVGLHQKHHTICLQNPLFHVFGTIATLTAAVNHGATIVLPNDTYNPEKNLSAIVQEGCTVIYGTPTMYVDLVSQQRKRNENMKAEIALCGGALCPPVLFKDMLDILKVKAVKSIYGLTETTASVFFSMDNENEYYSTQTVGKVHDHLEVKVVDSEGYLVPMGSPGELLVRGYTTMVGYFENEEKTKEVIDKNGWFKTGDQFILTEDGYGKVVGRIKDLIIRGGENIYPKEIEEFLITYPDIIEVQVVGVPHERLGEEVCAAVKTKSGNEITIEQLYEFCKGKLSTYKIPTQIKTLEKFPTTTSGKVQKNKIIEFFSKNKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5M0</accession>
    <name>A0ABM5K5M0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505474.1">
        <property type="nucleotide sequence ID" value="XM_050649517.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649517.1">
        <property type="protein sequence ID" value="XP_050505474.1"/>
        <property type="gene ID" value="LOC126883841"/>
    </dbReference>
    <dbReference type="GeneID" id="126883841"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="214"/>
            <end position="305"/>
        </location>
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        <location>
            <begin position="348"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF16064"/>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505474.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="424" mass="48555" checksum="F6A0B5822D01AA01" modified="2025-10-08" version="1">MSDSEFECTPPELRIAAERATEGIIPEKSRERYENTYELYTETELLKMSGGSATSSTDSEVLGEMKEKNKVRNTKKVTSQQNFETLFASSSSKFCSFQPIIPEETPEPVVESENIILETNFSDEAIISPEAIANAQFLNVIEQPLIGEESKNDIINKLNDIEQKFNQFKNDITESVKDMLVKAVAAIKSDFDAKLLSAMQNFKNNHQDDDNIQFEFHAVSTSQELSQLEENLKDPNYEKKVRNYFKKIIGNIPDTSNGLDTCYSIVDYFFEKKFMVQCSWTGGSRSNTEKCCIKNCKNILEVFFTIVQSSNKDFSKALLKKFIIGITRNAKKRSLTGGIRQSSIHRRKKSMVKKQRLSGKRKGVAQRQGENEIFYENEQSFNEEKEYDEDNDEYGMEKYEADGEDAIIEHDEVEEEDNNDTDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5X3</accession>
    <name>A0ABM5K5X3_DIAVI</name>
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        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505590.1">
        <property type="nucleotide sequence ID" value="XM_050649633.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649633.1">
        <property type="protein sequence ID" value="XP_050505590.1"/>
        <property type="gene ID" value="LOC126883914"/>
    </dbReference>
    <dbReference type="GeneID" id="126883914"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047119266" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="167" mass="17504" checksum="7E8A0F2CA71A1830" modified="2025-10-08" version="1">MNKKLVLLLNVLFSFVLKASLAQCSNEDKPAPYPTDCTKFYLCPGNFEMSCGPGTHFNSKILACDWPNRAGCKSGGPAKYQSPPGKPSGLPGIPPDPPLSPPEKPPVLPPGPPDKPTIPHGKPTGLSGKPPGTAFTPPGSPPGSSRKPPIPPPTSSKKIKLIKIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6F8</accession>
    <name>A0ABM5K6F8_DIAVI</name>
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        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
    <dbReference type="GeneID" id="126884034"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22710" checksum="1DA23EFEA0DAA6E0" modified="2025-10-08" version="1">MQKIETSYATSRTVNAKEHKILYYECNRSDTYGYKPHSKIRTEKSGGSIRIKGVCPSRLICKLTNQGQVSVSYWKTHAGHKEELRAIHLSKAEEKTIEEKLMAGVPPSRILQDSRKLEKPQLDRLALLTSQELANLSKKYNVHKKGDQNDMVATTLKVQEWNANNKNYAFLFKKEGKHQTFFLIPTTIIINPIPIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6J8</accession>
    <name>A0ABM5K6J8_DIAVI</name>
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        <recommendedName>
            <fullName evidence="5">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_050649862.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505820.1">
        <property type="nucleotide sequence ID" value="XM_050649863.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505821.1">
        <property type="nucleotide sequence ID" value="XM_050649864.1"/>
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    <dbReference type="EnsemblMetazoa" id="XM_050649861.1">
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649862.1">
        <property type="protein sequence ID" value="XP_050505819.1"/>
        <property type="gene ID" value="LOC126884080"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649863.1">
        <property type="protein sequence ID" value="XP_050505820.1"/>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649864.1">
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        <property type="gene ID" value="LOC126884080"/>
    </dbReference>
    <dbReference type="GeneID" id="126884080"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="5">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1380"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1552"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1621"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2034"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2094" mass="239918" checksum="D175A7EFA5032B53" modified="2025-10-08" version="1">MDPDNADGSNLRKKSVPSKDKQTRKMQTQKAVGEYPKGPVANLGTDYEWKLHCLFAVAAFKHFDNWSLANEYIEAGKFDDLVFKINDQCLLLQAKFKENKQVSDQHFWSTNPKSDNFSIYKYILSYNDIKWKFKGLKTNAIVLCTNANLPDSTFNPKRISENNIVNKIFGNQVEMGSIREEHRKKFDEVKTYQENISDVDKDKVTWKTISLNHNDIEEFMSKFIVIKVSIEQIDKQISYLIMSMEKKNPSLKNLYIINHVHYWRNLGSKHSVYMTKNYMRFIWYREENDRCIQQFLNYEISFLNPYQFLLAINLIKVEHNLDLYLTKIVNSINLIYKKQDKPDEMFFKEVLFLAIQSDYKTIENTVECFKIKNVKYLVVSFLEMDENQSKEIYIKISRILDTNKQKKVIIVAENFGFQDTNVENDQIRLNLFDENTKEIVYNTIIEFQGEAVTLKHLLNNFKVANLMDGCKSIDIMDKSYISSLFKSAGESCDLNRESYKELVESIKNKLSNDAPDLRNPTVLEFQGQQIVLDDLVTICKIEYLTDELFVLQLIKKESLSLGKYSIPSTTSEKYYVPRLLSIDFQNLFSEEFLLNELNTINKKVAVLTGPLGAGKTTLLENIILSRKLNDQKCSRLTWIINIELSKAAEYLQNKSLNPSLLGLLSYSEDTRGHFEIQALKSIEKIIVIDGIDENNSEYIHEVQDLIKNCPISENLNILLVIMACRNYDFILKKIRNKPDVETIVVEPFNEQDQEMFFEKYVTFKNATSVQKTKKVFFDLKAQAPGIKKFCSTPFALRLLIDILLNNEDHLEHISKIFSKSLSVYEFYKLFLEEKKKSFVQQQKWDRCVINSIVTDAFDTYLTKTRKFAASKSLPRELQELFNTDISPSINPSMLSIGIFEEKNGEFKFIHKSFEEYFAAEYIWNCLSHKRISDSILLALLNKLFLNTQYAGVSGFFEEILITKISDRGYNKISKEFGRVLSEQRWVESISLLVFQGYFNIVKFVFHEYDGFSKVINHRGTSGETALHLSAHYPHLVKYLVENGAEINCVDENGMTIFHYIIMMCWDSDKYKIYFNMIFEKMKYRDNFKTITFFDEYLKLICRDQQRGIRCKVEYDVILDLIDYLTDCGLDLSVKDKDEDTSVHWATQAGFPTLLKTLIEKYKLEYTAVDKYGYTPLHYACQFDSLGILEYFEQSELLCVNNSSLVSSYKPPTTVKILNDLDQQTESLLLKNKYLNLSAVDNDGASVIHRAASGNAVDILIYLINKYKLNPKLVDKYGNTPLHEAGSYNSLEAFTFLLETAQLDVNDCNNNGNSVLYSAAGGNAVKIIKYLYSKDEYKHLFEQQNNDGDTIIHSAARGDATDALTYLIFTCKLACDVTDKYGNTPLHSASSNDALEAFKYLLVQAKLDVNQCNERDESVVHKAAYANSMNVLKFLIDVYKLSPKLVDELGNTPLHDAAYSDSLEALKFLLQSEKIDVNDGNNVGDTVLHKAAFGNATKVIEYLHSQPAYAHLFNITNKMKDTALHTACIGNSIDALTFLVNRYPCLINSVDEDGNTPLHEAAFYDSLESFKQLLQCTKLDINIRNKESRTVLHLAAGQNSMKVLKFLIDDRYPCLINSVDEYGNTPLHEAAFYDSLESVKQLLQCTKLDINIRNTESHTVLHLAAGENSMKVLKFLIDDYKLSPKLVNEYGNTPLNTAAYNDSLEAFKYLLQSEKINVNDCNNMGDTVLHCAAYRNSTEIIEYLHSDPAYARLFNIKNKIKQTALHAACKGNSVDALSFIVDNYPHLINSVDEDGYTPFHEAAFYDSLESFKYLLQCTKLDVKICNQRGETVLHRAALGNSMNVLKFLIDDYKLSLKVVDITGNTPLHYSAVHDDTLEAFKYLLQSEEINVNDCNNRGNTVLHLAAFGNATKIIEYLHSDPDYKDLFNTTNKMKQSALHTACQKNSVQALAFFVNNYPDQINSLDEDGNTPLHEAAFYDSFESFTYLLECTTLDIKTCNQKGETVLHSAACENSMKVLKYLIDECNMSPTVIDIHGDTPLHVAAFNNSVEAFTYLLKTEKLNINDCNDKGDSVLHKAVHGKAIKVIEVIFTSFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6X6</accession>
    <name>A0ABM5K6X6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050505941.1">
        <property type="nucleotide sequence ID" value="XM_050649984.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505942.1">
        <property type="nucleotide sequence ID" value="XM_050649985.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505943.1">
        <property type="nucleotide sequence ID" value="XM_050649986.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649984.1">
        <property type="protein sequence ID" value="XP_050505941.1"/>
        <property type="gene ID" value="LOC126884134"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649985.1">
        <property type="protein sequence ID" value="XP_050505942.1"/>
        <property type="gene ID" value="LOC126884134"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649986.1">
        <property type="protein sequence ID" value="XP_050505943.1"/>
        <property type="gene ID" value="LOC126884134"/>
    </dbReference>
    <dbReference type="GeneID" id="126884134"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="441"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1321" mass="145619" checksum="ACF50FA6A71C271E" modified="2025-10-08" version="1">MDEKSEHGDQTAEIHDPVVGSLDEGMDIRMDPEADVSAVDSAENAGTSQDTETPEVAEPNIESAVGNDDNTLISELNDVSLSAAATSNETDSFLDSFTSENPTSESQANDDQNSNAADSDLSMPALVLPDEPNDMSTEDMSFNEKPEGQEEPVVEPPKDLAEAPVEAMKDVQKEPVYSLEEELERMHEESVQPETEPVQKHAESEKPEEVNVPESKVHTESKPTPIMKDSDLEEMLAADDVLQDPLMIKNAQQDLGKVDVLVCGNCHQVFHFVEEFKTHKSKICSTKSNSTLSNDSNSQVWAFTLWKTKQVKEEPGRGQTQWELYKTWCALPESDKTSWISAGELLQYCHKLETAKVTEVKVHNKPVAKDDKDPLSLDGFGKTDSNKENSSVDNSKSPLLDVKRTVINKPKPVPTVPKINNNSANTNKAMRSAPNLDKSEYAVEKIAAKRFNPKKKTWEYQIKWEHFTSEHNTWEPLSNLNHCRQMVDEFEEQLKKLKAEKAKQQQIAAAASKNTPKVKQIVSAVSSPSLAGTGPKNRPQRTSKQKALEQVKSWCGNISDEEGISMKRPRSPDSDDSFSEKRMKFEEMSEDSDGEVSKPKMPLRKIAPKPPASPLQVIKNGVGKNTPLPQNILIPDANGVVRINQKQLPSLSTGVYIMSKTAGIIKLDSSTSKVATSSGQMIVKVAPKIGQTHIKIMKKDGTSTQQVVQMSPKNIQQTPKALKSHLTKAKKSLSELKASPAAPKKAEVLKKQVLTPTKMDIDKKQMVVKKLPELAPKPGPKAFLKFNQVESREEESDDGLEELPFPEEIKLPEPEEEEADKDFILDPTTGKIAGVEYPEHEPEPIEEAKSDMSLDNIVKLAAADITEEDLKNEPQEEPMDIEVHHLVQAPEPVKIIKTEPQIVPERRFPTAASTKQVVKMPVTSRKVIANPTSILNKALTGPQVIRRAVTGSAEKQQRVLNHSMARPIVNPVVRQTKTFVRTKPVAPKPRFNIASDMSEKFIQPDHNTSPKNVYSFTRQVVPSPTMRKIGNTTIRSSPAGVSAANNQHKVQTTKYVRTSSGLVQKVVQTQVRREPMQVRGQPERVERKIQQKPKTVINMPSLISDDDLLLTTKPAQPRPKQAPVQPVQTIAALEAHEPEEAHKMAVVSEPSITQVPAAIQQEPEENAAAETSGINALAPDMSSFTLNDHDNPIFITGDDGTVYQVAGQNEQGQTILLTQGSDGQQQCLLVTNEIAETMETPAAEEAEPQQQEIIPEISPAVTDPLSIKTDVTESSDQVVAQVVRAEPPSPGGTHKVVVMLPDGNLMITQVSPEEYASLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7K3</accession>
    <name>A0ABM5K7K3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506167.1">
        <property type="nucleotide sequence ID" value="XM_050650210.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650210.1">
        <property type="protein sequence ID" value="XP_050506167.1"/>
        <property type="gene ID" value="LOC126884279"/>
    </dbReference>
    <dbReference type="GeneID" id="126884279"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="289" mass="33747" checksum="2A70F1DAF92B61F0" modified="2025-10-08" version="1">MAHMEIIINHYQHELETEFKTIHFLSDSPSSQYRNKKMFFYLQQVLPKLFPQIQHISWNYSEAGHGKGAPDGIGATIKRTADQLITFNHDINNFDVFVKCIQENISNIHIKCLNENNIEKFDAFLPPLLKPYKGTMQTHQVTWNHITRELSFRTLSCFKCSFENCIHYAIENKVAPLQSSYLSEENDNGRATARPTGIEEFSEDTWVTAIFDNDWYPGIIEKIDRNIMTVNFMMKNGKSFFWPDIADRQTVTTRNGILCQLVHPPEPVSNRFYKIQEYDYIDNLFKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7R3</accession>
    <name>A0ABM5K7R3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neuropathy target esterase sws</fullName>
            <ecNumber evidence="4">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Swiss cheese</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050506231.1">
        <property type="nucleotide sequence ID" value="XM_050650274.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650274.1">
        <property type="protein sequence ID" value="XP_050506231.1"/>
        <property type="gene ID" value="LOC126884349"/>
    </dbReference>
    <dbReference type="GeneID" id="126884349"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07225">
        <property type="entry name" value="Pat_PNPLA6_PNPLA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="175"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="425"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="536"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="20">
        <location>
            <begin position="890"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="323"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1210"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="16">
        <location>
            <begin position="894"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="16">
        <location>
            <begin position="921"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1213"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1279" mass="144018" checksum="4E7F388A74C6E720" modified="2025-10-08" version="1">MDVINAIKNFNTDFGIINKSTWLVNLVLQFQETYGVQFCGMICCWSFYVVLLGLILITTTLVVYCLRRCTRKVFKPKESISQETTRFRKRDKALFYGRKMIRKVKNISGQVRNSGQGKKRKMVMKFARRLLQLKKETDQEQLKVLEPPAEYLQEDMLSDDRMPPDALYMLQSIRVFGHFEKPIFLKLCKHTEIINVHAGAYLFRIGDPDEHVYIVQSGKLSVSITGNDGLTTLKIVKPGESVTSLLSFTDVLTGHTSPYKTVSAKAIEDSMVVKLPMSAFQEIFQEYPDIFVRVLQVIMVRLQRVTFTALHQYLGLSAELVRQHPKQKNSPMKKKKEESSLNTTLTETPTATTQPIPVPGHRRSKSSLESKSFSPSGNFGNGMAESDSIPSGTVSDCGSIPKKRLSIQNPDINDEELIEVATEAFVKELGLEDLDSLKGKVEIREVSAGTYLMKEDSNKDAALVYIIAGALVVSQRVTEGEEEVHMFTAHPGEIVGGLAVLTGEPSFFTIRAKHLTRIALISKSTFYTLMKDQPKIVLHIAHSVVRRLSPFVRQVDFALDWIFMESGRAIYRQDDESDSTYIVLSGRLRSVITHKNGKKELVGEYGKGDLIGVVEMVTQTKRSTTVIAVRDSELAKLPEGLFNAIKLRYPIVVTRLIKLLGHRILGTWKKPALNIHDTNSPAVDTRPSSVNFSTVAIVAASDDVPLTAFTYELNHCLSAIGSTLRLTSDVVRKTLGNSIMDPNNEYRLSNWLAQQEDQHRISLYQCDLTVSAWTQRCIRQADCILIVGLGDNHPSLGKVEKEIERLAIRTQKELVLLHREGGKPKNTIAWLNMRSWVSSHHHILCPNRVFARKSVNRINELYSKIHTTQPNVHSDFSRLARWLTGKSVGLVLGGGGARGSAHVGMIKAIYEAGIPIDMVGGVSIGAFMGALWCQERNMTTMTQKAREWSKKMTQWWRQILDLTYPMTSMFSGKDFNHTIKSTFSDTYIEDLWLPYFTVTTDITSSCMRIHSHGHLWRYVRASMSIVGIFPPICDPIDGHMISDGCYVNNVPADVMRSLGANHILAIDVGSVDDQDLTNYGDDLSGWWLLWKRWNPFTQPVKVPNLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDRYRTLQFGSFDEIREVGYQHGKAYFEGQLRAGNLPIVKNIMDVHRSSTTSTQSSLGNYTFTDLAQMVCKVSRPYEEEESNSSSSSEDEGRDGYASEPTVGISETENIIARRTGGSLSLSENELESDVDFDVNQRNFEKVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K8A3</accession>
    <name>A0ABM5K8A3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506417.1">
        <property type="nucleotide sequence ID" value="XM_050650460.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650460.1">
        <property type="protein sequence ID" value="XP_050506417.1"/>
        <property type="gene ID" value="LOC126884517"/>
    </dbReference>
    <dbReference type="GeneID" id="126884517"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="149" mass="17135" checksum="6D4CD4033210C739" modified="2025-10-08" version="1">MNLVCLFLQQVILTSFKYINCHLNATPHLYGMDGMDDKVVTYSDMKRLVNDRNALIIDVREVKEVKETGLIENSINIPLSLLRSALTSPKNEFKRTYQREAPNENTLLVFTCKSGNRALKALHEAESLGFKKCRYYKGSWNEWSQKKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBL9</accession>
    <name>A0ABM5KBL9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507585.1">
        <property type="nucleotide sequence ID" value="XM_050651628.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651628.1">
        <property type="protein sequence ID" value="XP_050507585.1"/>
        <property type="gene ID" value="LOC126885192"/>
    </dbReference>
    <dbReference type="GeneID" id="126885192"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="129"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="598" mass="68597" checksum="DD8371AF74C1879A" modified="2025-10-08" version="1">MNSAKRILKLALLQEAQEKNKDQNEQIDDLNDQIERCDQLESDAESEHELHDTDSEQSDCETVGDEFETVDELQPPEGEIFFNNTPIFRGKDKKTMWFKHAPKVYGRTKIQNLVVKIPGVKGIAREAKTPLECWKLFFPDDSIQEIVDYTNVYLGLMRKNYGRGRDCPDTNYDEIYALLGLLYLTGVKKSQDVDISELWTDDGTGPECFRSTMSYRRFYTLLRALRFDDHTDINIRMAQDNLAPIRKQFDGFVERCKENYQIGLYGTVDEMLEAFRGRCKFRKYIANKPAKYGIKIYALVDSTTFYTSNLEIYAGKQPDGPYRVDNSTISVVKRIIAPVLNTGRNITMNNYFTSISLVNNLILNHRTTVVGTLRSNEGEIPLEFVKIKERPIRSSMFAYSQKSVLVSYIPKKGKNVLLLSSLRHDDGAIDETTGKPEIISFYNVTKGAVDVVDEMKTLYSVSRVKCRWPLTIYFSMLDIGGINSHIVYKANNNKTEERRVFLKELALSLMKPHLINRLTIPHLPLSFRNSIAKIAKITLPNSSQPGPSDIQYCSFCPRRKNKRVKKNCNSCHRPICPQHSSYTCVMCVAANYEHMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCN4</accession>
    <name>A0ABM5KCN4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507952.1">
        <property type="nucleotide sequence ID" value="XM_050651995.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651995.1">
        <property type="protein sequence ID" value="XP_050507952.1"/>
        <property type="gene ID" value="LOC126885425"/>
    </dbReference>
    <dbReference type="GeneID" id="126885425"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="212" mass="24374" checksum="391CBFC140E65C60" modified="2025-10-08" version="1">MNNSSTWHRSGASIIRSSRVKKMVEAALSRQENVPGPEQSERVTDFTVLQNVLSERNEDFQNPEQSETVTNFTVLQNVLPERNQDFQNPEQSETVTNFTVLQNVLPERNEDFQNPEQIETVTNFTVLQNVLPERNQDFQNPEQSETVTNFTVLQNVLPERNEDFQSPEQCETVTDFTVLQNVLSERNEDFQNPEQRETVTDFTEGSKGADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCY9</accession>
    <name>A0ABM5KCY9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508054.1">
        <property type="nucleotide sequence ID" value="XM_050652097.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652097.1">
        <property type="protein sequence ID" value="XP_050508054.1"/>
        <property type="gene ID" value="LOC126885517"/>
    </dbReference>
    <dbReference type="GeneID" id="126885517"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="237"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="399" mass="45784" checksum="2D007DE2C46FAE43" modified="2025-10-08" version="1">MNISLSDVGHIAPIEILFGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKFWELDIIGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVMEIVNNHEENNSVHYLPHRRVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLRKALEKCCNDMPYSKNTIERLVIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGWESPGEEMMGLLAHLRLKPLIRMYWSFKECVDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD47</accession>
    <name>A0ABM5KD47_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508118.1">
        <property type="nucleotide sequence ID" value="XM_050652161.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652161.1">
        <property type="protein sequence ID" value="XP_050508118.1"/>
        <property type="gene ID" value="LOC114336804"/>
    </dbReference>
    <dbReference type="GeneID" id="114336804"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1684"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="753"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="912"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1561"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1793" mass="207065" checksum="44A5E4C13EE2E0B1" modified="2025-10-08" version="1">MYGRPKELEKLDLRIKVNGPCLTSLTSHQEERNKIKYITITTINSENSYKSTLQKVFGDKYHVPSDERIKILRSDVIPADEQTQTTHTQETQKSTSNQSDDFFSLNIVDPVMTTFNSRSAGITSSKSNSSVLALPADEFSTANTHFSEHSGLFVTDLPPLKILSGRCSSGAVQDKQLMRSLEERTNETENSITPQRDVEIMGESEGIQSDSNYFSPSSSLILPKKVPSALQEIDKMKKIKKTQRFLNTDILGKENEFNNEKYTQHASKLFRKVSSAISRKITASDIEIDYGKELDKEKEKQKSRARAHKAEITKKVSAAISTKIKLSDIREEIIEIDDDLQPEQKLGNEKEIRKHFGYIKEMGPKVSTVRKIRTCRIEREAIISIQDDLKDGKEKEEPKDDSVNAVELLQDTACSRQIKLSHTIQRAIISNHQDDLDCGKDLDKENEEQESTAHKAEITNNASVAISRKMKLSEIREEIIEIEDDLQHEQRLGNEKEIRKQADYIKKMVQKVSTDRKITSGIEEEAIQDYLEDGKEEEQADSVNAVEMLQDTAVLRQIKPSHTRQRANISSHQDYLDLGKDLDIEKVQKSSAHKAEMTKKVSAAISRNLKLREEIIEIKDDLQHEQNLNNEKEMRKQIEHIKEVVQKVSTDRKISCIEEEAITSIQNDLEEKQEIGNKKEEQKDSVNAVELFQNTAFSGQIKHTRQRAIMSSHQDDLEYETDLGKEKEEQKSSLHQAEMIKKVSANTLRKMKLSDTRDEIIEIEDDVSNSREEIIEIEDDLQHEQKLVNEKEMRKHIEHIKEVVQKVSTDRKISGIEEEAIMSIQNDLEEKQEIGKEKEEQKDSVNAVELFQNTAFSGQIKHTRQRAIMSSHQDDLEYETDLDKEKEEQKSSLHKAEMIKKVSANTLRKMKLSDTRDEIIEIEDDVSNSREEIIEIEDDLQHEQKLVNEKEIPKLTEHIRKLFQKVCTNRKISGIKEEAIMSIQDVEHEQEIAKEKEVQKNSVNAVELLQETDFSGREKLSHTRQTPIMSSHQDDLDFGKDLDKEKEEQKSSLHKAEMIKKVSAATLRKMKLSDTRDEIIEIEDDLQHEQKLVNEKEIPKLTEDIRKRFQKVCTNRKISDIEEEAIMSIQDVEHEQEIAKEKEVQRDSVNAVELLQETDFSGQEKLSHIRQTPIMSSHQDDLDFGKDLDKEKEQQEFSAPKKVSSAILRKLKPINTRQEAIIEIEDDLRYKQKLDDEKEMQRHTVHTVEMVQNVCTNISRKTRTSDTEQKSKRSIIYDLLSERISQCLRREKQKYNYNSPPKMFQNISTISRQIKSSKGIQKLLSVQEQEHEKAEERSTENYFQGYSQQKIQKCIANGSKMVQKLSTALSELKLTNTEEEPIMSIQSDVHPEIQLDNDMEIEKITENSSEMVQKLSTAISGKAKLNNRRHGTKMSIQCDLEYEQKLKNGNEERDQSKQIEILCDDEVAQTRSEISACTDVYSKNTEQPGVRQLVVILKRFDANIYQKKSTKELCSEHVRNINLKDAERETNTIDNVEKSLEKMFQSLDSGNSTTVQEKKTSHNKISLRRKRKSKESGPSSATHQDSILEMSHITDTSNAAIIYKRRRTLCNPNDITMLPDQDDEVERYRRRLSKEYPLQEELDLRRSNIIHSTPEKTKELSQSKRPVEDSINLDEINIQKCIEHTPANPIRKDSDSSNSLTKKHAKEHHLLRSSRKEKTKKRINFQDLPLFGADAINLHKTKKMTQKRRHEGFAKVNKDDRSMLNKSFHEIFGWSDDGETFLKEVLSKSCGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KEH2</accession>
    <name>A0ABM5KEH2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508589.1">
        <property type="nucleotide sequence ID" value="XM_050652632.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652632.1">
        <property type="protein sequence ID" value="XP_050508589.1"/>
        <property type="gene ID" value="LOC126885858"/>
    </dbReference>
    <dbReference type="GeneID" id="126885858"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF15">
        <property type="entry name" value="RE18252P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="383" mass="43267" checksum="F2CC13A675257D31" modified="2025-10-08" version="1">MPFMWTNELVLELIENYKLCECLWNTKHAQYKCRNAKHDAWTTLAEKTGSNIEEVKRKMKNVIAQFYRERKKYRTLKKSGAGAVFISKWFAYEVLLFLAGRNKVRKCTEKGITTSEGEDDGSDSSATDSGEVESQDSNIADEADAVTDSSFIVGEANNDVDTLNKTVAAITETPTKPNENRTRSPTPSTSSTTKSKQGPRLFKSPKTMKKRQADVKTDERQEEAYVLLKQLQNKKPRNRFQIFGELVACKIENLQNEDAKNTVEHLISNILYDASMGKYDRPFPCYQSWHTPSANNNTARYYSDNQNYYSSSTNDSVTSPASTTHTPMPSPNSSCYETNYLPQTETNNSTLSKEKQPCRNLQESSISDAIRLAMSDAGLDVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFQ0</accession>
    <name>A0ABM5KFQ0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509015.1">
        <property type="nucleotide sequence ID" value="XM_050653058.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653058.1">
        <property type="protein sequence ID" value="XP_050509015.1"/>
        <property type="gene ID" value="LOC126886199"/>
    </dbReference>
    <dbReference type="GeneID" id="126886199"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="355" mass="40480" checksum="14931505DE3E9C7A" modified="2025-10-08" version="1">MGDNRGITQLCTTGNLAENWKTWRARFENYLIASEINKKSEETQCAQLLHYIGEEGFKIYTTFAFAEDEKNKLKCLLEKFEVHFQGKENIAYERYKFFTYKQDPEQPTNNFITELKKSAGKCKLEKLQDSLIVTMIICGIKNNEIRERLLQEDGLTLEKAIELCQVIESSRARSEMMRVGASSNVIEVEAVNKSGSCYQGGEKEKHQEVSQNIQNCNKCGQRSHRINNCPAFGKVCNFCKLPNHFATVCRKKKFQNKKVNEINTVTKSPKVTSSCNDLFVDNVLEVNAGENNFTNTAWFADLNINKHKITFKIDSGAMANVLPMSIFETLGFSYRVIMKTNTKLQSYNGNNLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFS0</accession>
    <name>A0ABM5KFS0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509047.1">
        <property type="nucleotide sequence ID" value="XM_050653090.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653090.1">
        <property type="protein sequence ID" value="XP_050509047.1"/>
        <property type="gene ID" value="LOC126886226"/>
    </dbReference>
    <dbReference type="GeneID" id="126886226"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="323"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="833" mass="94714" checksum="431E4659B1B99984" modified="2025-10-08" version="1">MEQGQINKLTRSKTASKLDLTRLCSSVETDLASLTKYMIKEILCQLRDAFRTYNDATNLLAAELATTEDVDPIVKKYYKCISLLEEKLESLLTPPTSSTASEISSVPNPNVPSPSTQITQNATTKQRTVKLPELRINNFSGKLKSPESQTTDENLSQIVQKFWESEEVNPPISESVENHPSELLFLKTVKILPSGRYQVNLNLKHSVDDLHMGNSFITAKKRFFYLEKKLHSDPVLLQSYSKIIQDYHSQGLVSDVPLQVRNFDGKFNYFLPHFPIIKTSSTTPVRIVFDPNNKSTSGICLNQVLDKGFTVQPELFDILITFRHYKYILAADIKHMFLQISINEQETFLLNFLWRDKQDDKLQCFRFNRLPFGLSSSPFLATRVLKHIADTHAISHPSAAKTLLNSTYMDDVLSGGNNLEEIETLHFQLSSLLSKHGFQLHKLSSNHPEFLKKHKLIPTPEIKLSLAGSSDKILGIIWSPDQDTFSFKPPVCEVTSPITKRKILSYVSRLFDPLGLLSPTLVYSKLLLQRIWSLSLDWDTPITNDKILSDWQSLLTKFQSINLTKFPRCLVLDKKVILTQLITFCDASQDIYAACVYLRVTYDDSTVSVRLVTSKTKIAPLKNKLTIPRLELSAILLGIQLTHRSQGILQKDLKISETHLFSDSTIALTWVTTSKFLYNQFVQSRVIKIRSLSESYQFHHVESKQNPADLPSRAKSICSNAELTDLWLHGPKFLIKPEIDYSLFQIKKWNGELPELRKNQVSLNVTVTAQSNDTLDDLFNRCSSFTKIQRSLAYVLRFVSNLKAKSNHTAIDTDVLSVEEIEFSTCLVLKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFS9</accession>
    <name>A0ABM5KFS9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509056.1">
        <property type="nucleotide sequence ID" value="XM_050653099.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653099.1">
        <property type="protein sequence ID" value="XP_050509056.1"/>
        <property type="gene ID" value="LOC126886235"/>
    </dbReference>
    <dbReference type="GeneID" id="126886235"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58207" checksum="2B8CB7DB7C4B0EC4" modified="2025-10-08" version="1">MPESKETKESEKLRKSRESVRNRLDTFAKYIDKIAIPGSSDNLPVTELSVRLDRAETIIEEFEVVQGKIDALVDDVSVEIKYREDFENVYFSTIAKAKELLQPKPIISSNENANQSSVSDRNSSFSSGIKLPTLHLRQFSGNYSTWLDYHDCFDTIIVKNNDISDIQKFHYLKSSLSGAAEKIINSIKVSAANFTVAWKLLCDRYSNEPLLIHNHIKSIFNLKVVNRDSSKCLQHLIDRLTSNLRSLESLGEPVSTWDSIIIFIILEKLDPETVKDWDKESRVNAPTSVKPTLDDLLKFLQHRADTLEKFEARSIKGGSSSKDHSHSSSHRSKTHTSQSFINNGASSDLCPHCNGPHKMSTCTSFQNLDVHARMREVKRVRVCFNCLFIGHQNTSCKYGKCKKCAKKHHTLLHVNAENSNSPNDTQSVSSDNQTPQTLSCHAVQNSFALLSTVTVQIPDRSGVKHNCRALLDSGSQSHFVTYSLVSKLGLSKEPADISVVGVTQISSRIKHKSVCIASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG46</accession>
    <name>A0ABM5KG46_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509176.1">
        <property type="nucleotide sequence ID" value="XM_050653219.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653219.1">
        <property type="protein sequence ID" value="XP_050509176.1"/>
        <property type="gene ID" value="LOC114325317"/>
    </dbReference>
    <dbReference type="GeneID" id="114325317"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="241"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="694" mass="75734" checksum="793651B2A922A16C" modified="2025-10-08" version="1">MEETTKISEQHELKNSRENINIDENKITTTGENSGHNNSEKDDNQEDNMDKEIHSSLAADSVKSHQLEQSNGHLNHSFDHHSGDHYPHFNRNLEPPHMHHGHLNHAYEQSSKPTSRKVSAASHVDEGPVRKKSFMHKSNSDKALSVSAIDSHSNCDENESPSIWYDFCLKINSPEESRKQYQPEIWKRVCPQPYCPSYRKVTRIIALTLIGLLAWCVLYAIVGESAAPPKGQLFQLIVLSISAHFGGWLFGLTTLPALVGMLFTGIALQNLNIVNIDSSFSHLNKHLSAVALVIILTRAGLDLDPTAVNRLKFTVLKLSVIPWTAEACLTVILAKFWLGTSWKYSILLGSIIAAVAPAVVVPCLFRLRSKGYGVVKGIPTLIIAVAGIDDALSVAIFGVVLGIIFTGASVAKGIIFGSLSILAGIGIGVIWGIICNITPERNDPFASPLRILLLLSGGLAGVFGSELVGYGGAGPLICVTAAFVALTNWSKQGWHVEENPAALAFEIFWMIFQPILFGITGSRIKINEMDGNVVLVSLGILAIVVVVRIAVTILVGIGCNMNLKEKLFVSVSWISKGIVQAALGPVALSLLENKRSDEVIEAQKIMQCCILSIILTAPTGALLTTILGPILLTKEKPLPPELRVRKKSRRQSFLSPDLLLNEDANNEDREQGHNNITITSIVEEEKDDEETVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KG84</accession>
    <name>A0ABM5KG84_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509200.1">
        <property type="nucleotide sequence ID" value="XM_050653243.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653243.1">
        <property type="protein sequence ID" value="XP_050509200.1"/>
        <property type="gene ID" value="LOC114333684"/>
    </dbReference>
    <dbReference type="GeneID" id="114333684"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046378446" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="301" mass="35501" checksum="224DA18B3E02AE35" modified="2025-10-08" version="1">MAKKPLAIFFLCALIWKENAVEGKFKFSLKWESSEEPREAFPVKNLPSINLLQNTNFSARNLPTFRNSVYEMGVDTYQGNFFGAQEYCRSLNMSLVSIESEDENYFLYQLMKERFGDSMEYWFWTSGAKLDNRWIWMSTGRPIKYYNWMRFQPDNIRNKENCIEVRFNWYTGLGWNDRNGLDCGVHALCEAEIEPVKTLKTLTTPIIRTTTPDVWDTTPIIRTTTPAIRTTTPDIWNTKPDIWYNTPPIARDTTPDVRDTTPVIRDTTPDTIWNNTYLTRETDDKWSSTPDYYYAYTYDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGL2</accession>
    <name>A0ABM5KGL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509347.1">
        <property type="nucleotide sequence ID" value="XM_050653390.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653390.1">
        <property type="protein sequence ID" value="XP_050509347.1"/>
        <property type="gene ID" value="LOC126886449"/>
    </dbReference>
    <dbReference type="GeneID" id="126886449"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="555"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1509"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1781"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1917"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1985"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2053"/>
            <end position="2086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="2130" mass="245632" checksum="86F2A31FBEBE70E7" modified="2025-10-08" version="1">MKMHSEEVSSVWLNRRYYEDAEIAHYEKLAKLTAERAKVMDSGKAQTPSQGLPYEISLHTLFALSAIESYTNWKLLNEVKLAGKFDDLVFKSDEKCMLLQAKNVKGGKNTQDFMTENPKKSDFSIAKYFLSYLTLKNFYEITPNSLILCTTARLNVDNIMDELPADAGPANLQKMFGLEPKKYRLKKEIMVDKLLNTTKQFQKNISKEETDKDKKEWKELEINREDIQSFICSFVVVKINLTNIKALIVSKLNKLDYQCKFPISSYEYVKVHVEDWYYLPAEKSMPMTKDYFMFILCGEHNRNFLQKLVSTKIYFKESYQLDSSNIFCVQIHDNISMYILKILRSIQKSETPYFSLKENTLCLMQEMEKTFHKMKYTMEQKVICDMMNTFRCDKIKYLIVSFLSLNQDQAVNFLKEISEYMISKKDSKKKVFIIIKEHYLQNSDPSVKIINDKIYFNSLETETKQHIYAKEIQFQGENVTLNNLITKNMNTELDDYQIKIDKGLKKIIFSEYTYSIGSNMQTQSKQKQENYVKRSLMANSGEFPEREFFEKIEKKIVVVTGPPGAGKTTLLKQLVSLKKAEDSKIRKKVKSKLTWIINVDLQKSKQFFRNDIEKTIYNLLCQNENITPDSSYFEGKLIESMGKILIIDGLDENCSEVINKIQNLLADHNSLQALNISLVIMGARDYNLILNLKKLRDLDSCELVKISPFSPCDQSSFFKKYLKQLLPAASIENDLFEKVINLAPAFKDICSTPLSLEMVSKIIKNKISKCDSIKSLRKVFDNVTNTYDFYNCYLQAIKDEFAQDDEIRLGAFDGYIDSLRKFAVKNLFSDASDFNLLGLFNVDDDFEIRKDVLNAKLLKESDEGYAFVHYTFKEYFAAELLWDCLYKKRHSHDLLLEVFNKVFSTYEYKGVCDFFELILEINQNEKIADLSKEYNSALNKVNWENNKSMSSIWTYFFIVKLVFDNYTHFYDILKNNDQIIRTAFINKRYRQSFAKYFVEKVAKVNKVNKIGFIIITALLYHDCRFNLEPVDDPKFESDVVSDFDYVFYYDKYDFNDMFMYGMYDSESYDSAISGVHYPEYAVDFLKLLTREYNIDLNFCDRNGNTISHYAVQYNSLNTIKYLKEQGADLSISNKTKRTLVHEAVRKGSFEVLRYLLEDCKMDVNVSDVYGNLPVHMRKTVDNNINILKYLKEKGANLSISNKDKSTLIHEAARNGAFKVLRYLVEDCKMDLNVSDVNGNLPVHMISMRDYNIDIFKYFKDKGANLSISNKDKCTLVHEAARNGAFDVLRYLVEDCKMDVNVSDFHGNYPVHMLKMVDANVKILKYLKEKGANLSISNKDKSTLIHAAARNGAFEVLRYLAEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDEGVNLSISDKDKRTLVHEAARNGAFEVLRYLVEDCKMHVNVSDVNGNLPVHMIKMVDGNVTILKYLKEKGANLSISNKDKHTLIHKAARNGAFKVLRYLVEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDKGANLSISNKDKLTLVHKAARNGAFEVLRYLVEDCKMDVNVSDVNGNLPVHMIKMVDGNVKILKYLKEKGANLSISNKDKRTLIHKAARNGAFKVLRYLVEDCKMDVNVSDVNGNLPVHMISIRDYNIDIFKYLKDKGANLHISNKDKLTLVHKAARNGAFEVLRYLVEDCNMDVNVSDVNGNLPVHMLKMVDANVKILKYLKEKGTNLSISNKYKCTLIHEAARNGAFEVLRYLAEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDKGANLSISNKDKCTLVHEAARNGAFKVLRYLVEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDKGAKLSICNKNKCTLVHEAARNGAFKVLRYLVEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDKGANLSISNKDKCTLVHEAARNGAFKVLRYLVEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDKGANLSISNKDKRTLLHKAARNGAFKVLRYLVEDCKMDVNVSDVNGNLPVHMISMRDYNIDIFKYLKDKGANLSISNKDKCTLVHEAARKGAFEVLRYLIEDCKMDVNVSDFHGNLPVHIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KHM9</accession>
    <name>A0ABM5KHM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509716.1">
        <property type="nucleotide sequence ID" value="XM_050653759.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653759.1">
        <property type="protein sequence ID" value="XP_050509716.1"/>
        <property type="gene ID" value="LOC126886741"/>
    </dbReference>
    <dbReference type="GeneID" id="126886741"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26811" checksum="6785E58BA055FD6B" modified="2025-10-08" version="1">MVKLSNARVNFNPKLLKKLTQKENSGVEVHTTVQHLAIYPHQLNNFNDSVKGLLNAKIAKYNKTFNGILLGYKNIKLLKDGGVIQDDSYYIHFDLQADFYIFKPEIGKIMEGVVKRKSKDHIGALVYEAFNVSIPLTSDDDEEELGNTVKVGDTVTFQIIYINLTSRLPYIRGRLMSETTETETNEISEIKIKKRKKKSKTETTETETNETTETKVKKKKSKTKEKKVEEMEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI85</accession>
    <name>A0ABM5KI85_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499950.1">
        <property type="nucleotide sequence ID" value="XM_050643993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509905.1">
        <property type="nucleotide sequence ID" value="XM_050653948.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643993.1">
        <property type="protein sequence ID" value="XP_050499950.1"/>
        <property type="gene ID" value="LOC126880208"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653948.1">
        <property type="protein sequence ID" value="XP_050509905.1"/>
        <property type="gene ID" value="LOC126886850"/>
    </dbReference>
    <dbReference type="GeneID" id="126880208"/>
    <dbReference type="GeneID" id="126886850"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="70224" checksum="09E892F13E3E8FB4" modified="2025-10-08" version="1">METSETSDDGDQFIDEDIFKTEDTETQLLPCSSTELGNWAIRHNITHAALKDLLQIIKRQYDSSLFIDARTLLKTPKNTKKSCKVIQGGEYWHQGLDVCLTNTFKNLSKDMLIQLNVNIDGLPIYKSSKRQFWPILCSIYEMPDIQPMIVGIFHGNNKPLDINEFLEPFVEDVKRLQSNGLCVNGHMIHIKIRCFICDSPARAFIKGVVNFNGINGCLKCTTEGEYSYLSRTVVFPDIKCPLRTDAKFRSKHYGKHHKGQESPILKISEVDMVQDFIVADELHLLELGVMKRCLTGWKDGSMGFSSKLCARDIERISKHLISVKLPSEIHRSTRGLDCLAYWKGVEWRNFLNYIGIVILKDVLNTDVYKHFLLLFVAVRICSSDMYAENRSVAQLMFEKYIDDFKIIYGVQFITSNIHNLEHVVDDVNRFGQLFTISTYPFENTLFQLKKLLRQGNNSLQQIVNRIGERNLILSNDTKKTSLQPEIKKRGNVIKCYIYSHNFCLSNVFKNSWFLTNDNDIVQMNSVSEKGGKIFIHGKSVKKKEDFFSYPIRSSNLHIYICNITNLNNMKLYLLENVVCKMVVIKYNESKIVFIPLLHTIKNKQNLNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKE8</accession>
    <name>A0ABM5KKE8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050510676.1">
        <property type="nucleotide sequence ID" value="XM_050654719.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654719.1">
        <property type="protein sequence ID" value="XP_050510676.1"/>
        <property type="gene ID" value="LOC114339447"/>
    </dbReference>
    <dbReference type="GeneID" id="114339447"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="537" mass="62451" checksum="16732DC7284216E9" modified="2025-10-08" version="1">MGICRLCLQTEGEKMMSQKVLELLKKYIPGMYSIVRNLDLLLCEICFTNIETLSAFVGTINDTNEKIKAAKEATADKIDLTRLVQTNNNCQGKVSSACRLCLKIIFMPQIFLYENESNVLRHDLILEMCQICMISMDLELSEHPVMCWECWENLQICYSFKKSCLDIDKKITSYRTIFCLTKKDITENIFTEMCNYFSQNLDDDLIKLSRIIEKEDELLENCLDVSRYTLRNNVKREYKREDCSNNDKVCENKIMPKSNSKRRRHCFTEEDDNFLLEAYKGVNNTENSLRKTIWPQIQMKWLASFPDKPLTICSIIARINRLLQKTGEIKRARRKKILPRPPKKPFVLQNILLVPAINKAAVEYKESFTEDIPSLKMESLSNEEVHLTEFKLEPLSDCPPSDSDSDSESLPIPDLERMDVRDSSNVWINVSRELEEEEEEEEKDDDSECVIVKYYKQFLSTTKMYADKSVTTYKCNGCDFETKCQYAADCHTSCNNLECEYCSFETSKLSTLIQHTSEVHKFDIEDDDIPELTPFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLT5</accession>
    <name>A0ABM5KLT5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511158.1">
        <property type="nucleotide sequence ID" value="XM_050655201.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511159.1">
        <property type="nucleotide sequence ID" value="XM_050655202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511160.1">
        <property type="nucleotide sequence ID" value="XM_050655203.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655201.1">
        <property type="protein sequence ID" value="XP_050511158.1"/>
        <property type="gene ID" value="LOC114348211"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655202.1">
        <property type="protein sequence ID" value="XP_050511159.1"/>
        <property type="gene ID" value="LOC114348211"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655203.1">
        <property type="protein sequence ID" value="XP_050511160.1"/>
        <property type="gene ID" value="LOC114348211"/>
    </dbReference>
    <dbReference type="GeneID" id="114348211"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028500" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="169" mass="18173" checksum="042CF6FCCE4176B6" modified="2025-10-08" version="1">MNLHHCTLLYLLVILFHVSSSLPSGHQSAPIIKPFGSALDTVENGITNVAKSKAISPGFPDSGRTRAVLELQSKESAPLQLDNKYGTLQEFVARIFNPKPVVDTAQEYEKYGNDAATQNRIAHLFIGGVEGFSNVLNAAVEVPFIATKQFGKTLTTSLNTFGGKLVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMP2</accession>
    <name>A0ABM5KMP2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511466.1">
        <property type="nucleotide sequence ID" value="XM_050655509.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655509.1">
        <property type="protein sequence ID" value="XP_050511466.1"/>
        <property type="gene ID" value="LOC114333083"/>
    </dbReference>
    <dbReference type="GeneID" id="114333083"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="389" mass="45298" checksum="B62522FB7B001219" modified="2025-10-08" version="1">MTMDYTIEKCYEVYKIECLSQNQECVSADKFRRVFTEDFNIKFKSPKSDTCHICDSIYVSMKEATIQRNEEQIQALQLKQELHHRKAKAGQDAIKNATKTAQENNETYAITFDLQQALPTPKLSTGPTFYKKKLFSYNLGIDSLYPSQGYFYLWDESTAARGADEIGSCLLKHFQIHNIKGHTLIAISDNCIGQNKNWSLVGVWLRLLALGNFKEIIHIFPQVGHTMLPSDRDFAVVEKYVRAHCQYVYSPAEWENILRTCQRKNPFIVYKMNQEDFLKVSEMRNYFVQPKSTPANPCSIRNAVRMRFSAENFEHIEIADTYNGEFNSYSIQKRERTGILQEHFIQDLQKKYATRLGIEPSKLEHVLSCLEWIPSVHHEFYRSLFAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMX9</accession>
    <name>A0ABM5KMX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein SmydA-8-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511527.1">
        <property type="nucleotide sequence ID" value="XM_050655570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511528.1">
        <property type="nucleotide sequence ID" value="XM_050655571.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655570.1">
        <property type="protein sequence ID" value="XP_050511527.1"/>
        <property type="gene ID" value="LOC126887766"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655571.1">
        <property type="protein sequence ID" value="XP_050511528.1"/>
        <property type="gene ID" value="LOC126887766"/>
    </dbReference>
    <dbReference type="GeneID" id="126887766"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF2">
        <property type="entry name" value="AT24727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="42"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63897" checksum="FE876110E0841B0D" modified="2025-10-08" version="1">MSEKCEICEEPSELKCSACRLVSYCCKDHQKQGWKAHKPLCRPFEIQEDPVIGKCLVATRDIKPGDLILSECPLVYGPRPHMVEEGPVPCPGCCKLIIGEQSARCEGCDFPICHPACPGLKDMEKHGHECMILGLRDVKAINGLHDFYRQDALLVLRCLLLQNKHPKKFAQLMEMEGHLKKRGADVTSQVQERIVDYLHSNFFHPMTILEGRSGRKVLEDLSPETIQKLCGVIDVNALEINQNAEVSALYPTIYLLEHSCLPNTTHNFDNDTYKVNLKASSHISSGEHITTMYTHCLWGTQARREHLRETKYFDCQCKRCSDPTEMGSYLSALKCIGTNDEPCGGTQLPINPLDDKTEWTCDQCTVKISNEEVSFLVNGIGEEVDNVQLANPTVRELEALLNKMLTFLHPNHYHVYAVKHSLIQLYGYQQGYTPTQITDDCLVRKAAMCRELLDITRKIDPGNSRLALYHAVLLHELFLANWITIKRKWDLGIKAKVKSVLTTMNECKTCLDQLQEVLKNEKNTPAGDKLINLVNNSTKEFNNFVVRNKIDLSGQIKEKSINGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KPJ8</accession>
    <name>A0ABM5KPJ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512106.1">
        <property type="nucleotide sequence ID" value="XM_050656149.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656149.1">
        <property type="protein sequence ID" value="XP_050512106.1"/>
        <property type="gene ID" value="LOC126888144"/>
    </dbReference>
    <dbReference type="GeneID" id="126888144"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045983657" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="147"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="410" mass="44193" checksum="0E17F923A9376815" modified="2025-10-08" version="1">MVSPLVGIAVLCLVCSINGQQGEDLDSLINSVFSRPAEDKPTTEATKPVTSSPGINLQPVESHGGETGIPGIGECNCVPYYLCNNGSINTNGEGIIDIRINEGPCGNQYIDVCCDKKNTVDEPITPTPNTNTVGCGHRNSRGAGVRITGATDGEAEFGEFPWMVAILREESVEGNPLKLNVYQCGGSLIHPQVALTAAHCVAGKNKVFKVRAGEWDTQHEKELYPFQDREVQSIVVHPQFYAGALYNDIALLFLKSPVSAAEHISTVCLPSQNQAPSGSGFATGWGKDQFGKKGKYQVILKKIELPVVSNNICQDKLRTTRLGRFFELHNSFMCAGGEPGKDTCKGDGGSPFVLSTGTEEDKFYQAGIVAWGIGCGENGTPGVYVNIAKFRSWIDEQMAKQNLDTSTYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQA9</accession>
    <name>A0ABM5KQA9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512375.1">
        <property type="nucleotide sequence ID" value="XM_050656418.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656418.1">
        <property type="protein sequence ID" value="XP_050512375.1"/>
        <property type="gene ID" value="LOC126888289"/>
    </dbReference>
    <dbReference type="GeneID" id="126888289"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="484" mass="54916" checksum="A4424665337857FE" modified="2025-10-08" version="1">MKLVGEKRTGLFSEFYLKCQMCNCLKTITSDKKSENKVNINSSIVLGSISTGIGYSQTSELAATLDLPFMTLKTYNNYHEQVAEFIRASAWQTMELAAAEEIKMAKDAGNVDENGIPCITVVTDGAWSKRSYNVNYDAMSGVACIIGYNTGKLLFLGVRNKYCSICSWHESKEQETPTHRCFKNWTGSSTAMETDIIAEGFRNSLNQYGIKYSKMVGDGDSSVYRKLLEIRPYGNCLVQKIECKNHILRNFAKKIREISSKKRSNSQNKPVPITLRKCVLSRFMRLRSAITKATTYRIGENTSLEEKVQLLRNDINNAPSHVFGEHNLCKTIKYFKCEGQDTNIIPVMKECGIYEDVMSALQRVIDNASSLIMNMDNNLAEHYNSVVCKFIGGKRINFSLRGSYQTRCEAAALSFNSGGEYHRMINKTMFGNSPKGFYKKFYLKKKKEHAKIKARRTLFPKKKRNRLNKTCQIRITAPMPTICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KR10</accession>
    <name>A0ABM5KR10_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050512620.1">
        <property type="nucleotide sequence ID" value="XM_050656663.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656663.1">
        <property type="protein sequence ID" value="XP_050512620.1"/>
        <property type="gene ID" value="LOC126888414"/>
    </dbReference>
    <dbReference type="GeneID" id="126888414"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045239805" description="beta-glucosidase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="495" mass="56877" checksum="5AED1B683A15E4EA" modified="2025-10-08" version="1">MVSKQVWLISIVLSTSFATTINVSKFPKDFMFGTSTASYQIEGAWNEDGKGENIWDRVIHRVPSPVIDNSTADIACDSYHKYKEDVAMLKHLGVTHYRFSLSWSRILPTGFNNKINPLGIAYYKNLIKELRANNIESLVTIFHWDTPQPLENLGGWTNELIVDRFVDYAKVVFENFGDDVKYWLTFNEPKQTCNGGYGNMQRAPLVDSSGIGEYLCTHNVLKAHAKTWHLYDKHFRSTQKGKVGITIDTAWLEPDTNSTRDVDAAERGQQFVHGWYTRPLTLGDYPELMKKTIAKRSSLQGFSQSRLPQFTKDEIEYLKGTLDYLGLNYYTTFMARDSDDEKIDDISFEADAQISAYQKDEWPKSATPWLRVVPWGLRKTLNWIKNIYGDIPILITENGVSDNASSLEDDTRVDYYQQHLSSLKDAMDDGVNVFGFTAWSLMDNFEWLQGYTEHFGLYRVDFSSPNRTRTPKKSAKYFKNVIQYRCVLGNSTCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRJ5</accession>
    <name>A0ABM5KRJ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502185.1">
        <property type="nucleotide sequence ID" value="XM_050646228.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512810.1">
        <property type="nucleotide sequence ID" value="XM_050656853.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646228.1">
        <property type="protein sequence ID" value="XP_050502185.1"/>
        <property type="gene ID" value="LOC126881755"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656853.1">
        <property type="protein sequence ID" value="XP_050512810.1"/>
        <property type="gene ID" value="LOC126888511"/>
    </dbReference>
    <dbReference type="GeneID" id="126881755"/>
    <dbReference type="GeneID" id="126888511"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="326" mass="35256" checksum="42C517BE40CDCCD5" modified="2025-10-08" version="1">MDGRKRLSGWQYKKVAEEKKKKLTEVVNKTAKLDTFFTRSNLPVPPEPVLLESVKEFCEVELEVCSILTPSASTASASVPSALTSTPPASASAPSASTSTPLASASAPPVSTSTPSASASTPSASPSTPSASAPSASSCVDTDKIKPAISELTFVVDEIEDQLTVSEPDSSVHLKPNYDPALWIVNEETREYFVKNGWNQNKDCDFKKSERQYPDRKRVLAKWLFDRKLANGEIPLPNCPVFAHKSTAMTDYGSKPAGTFTGEPSPSNEAEFSLHSKSIILSQNSHKTIKELLSLGITSCMMFHKIISTTILFTIIVILSNGISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRW0</accession>
    <name>A0ABM5KRW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512926.1">
        <property type="nucleotide sequence ID" value="XM_050656969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656969.1">
        <property type="protein sequence ID" value="XP_050512926.1"/>
        <property type="gene ID" value="LOC126888612"/>
    </dbReference>
    <dbReference type="GeneID" id="126888612"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="106382" checksum="DF294768EDC1C1A9" modified="2025-10-08" version="1">MALELETKRRTVLRTAFTTAANVLDNLLSETVDTRPWQQISVQWELLQVKYNELCVVESAVFEAMVEKASEAELISEMEAKDRYSTRYYELKYKCEDRPSLVSSESSIKAYLRQATVDGSKARRLVESFPAVADNYSKIIKSLKSRFGREDLQIEVYIRELLKLILSRVSSSSCNVSALYDMIESQLRSLETLGITADKYAAILYPLIESCLPEDMIRLWHRSSQFLRPSGSVSMHNVEEYAEVSTLETRLSGLMSFLQNEVQNEQKINLATEGFGLSTENKCKSNNLVEKKNIKLPKQGTDQPSATAAGLVNYEVDRCIFCEGQHDSINCFKAQKLSMEQKRRTLSEKKACFRCLKVRHSSKNCRARLNCILCCKSHVVLMCPDLPVNKIDTSTSSISRSEENRTEDQTLANLNNTQVFLQTLRVNIRSAHGTKQVRALIDTGSQRTYILQRTAQEMGFSAKGTENIVHTLFGGKSTSEQRHKLYKVTASEGAYSCSFDALDQPKICADVSPVYHGPWVEELSDMNISLSDVGHIAPIEILLGADVVGKLYTGRKYQLQCGLVAVETLLGWTLMGKVPAVASNFSTSMMSIALFVDSSSVAKLWELDIIGITDPVEKLTREVAAKEAKNFFYETIRCDNEGRYEVMLPWLNKHPLISDNLVVARRRLDTTLNKLKKSNLFESYNLIFNEWLNEGVIEIVNNPEENNCVHYLPHRPVIKNTSETTKIRPVFDASSHEQGRPSLNQCLEVGPNLIELIPSVLLRFRQQKIGVVSDIRKAFLQISVHSKDRDFLRFLWVNNEGKEFVFRHRRVVFGVNCSPFLLGATIEFHLIKALEKCCNDMPYSKNTIERLMIGFYVDNCVTSVTDENELRKFVSEATAIMEEAKMDLRGWESSGEGMMGLLACPLEIETIRMYCSFKECVDIGYYVFKSVEFVTFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRW1</accession>
    <name>A0ABM5KRW1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512930.1">
        <property type="nucleotide sequence ID" value="XM_050656973.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656973.1">
        <property type="protein sequence ID" value="XP_050512930.1"/>
        <property type="gene ID" value="LOC126888617"/>
    </dbReference>
    <dbReference type="GeneID" id="126888617"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="415" mass="48142" checksum="DED3110FFCA7B344" modified="2025-10-08" version="1">MECPYIVIGIDELDKYGTEINFANNYIKFGEDILEEGLKEKEDEQEDSTAPNKVCTSMTNKQVENKEEKEEEDIGNEVNVLTTNFKSNKMRSVVSQTMYTDERKEGKKRRRKNRKKRSVTPIQVDTNIGPEEKEEQEENLNVSTAPKVLCTNMTQKEVEILDEEETELETENEDRKKKTPGGLVTLRMESDNEGRKKTTGGLMTLSDGGGKFREPDLPKKKKTKKRIEKKNNKDDYTTDEETKYDEDMDHETAKKPASKRQRTSPLNVSEDEKHEEIETLKKVIQQQADDLKARDEEIKSLKAQIEDLKNTMVQTNKTLLKRMDERFDQLAENQNMKTTPTTKNKEATPTKQVQPTKYDQTNKYPRYNLLRLSTSIHGSPSNHAPVPYKEHMPFLQYDQTNKHSLKTVWLNHKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWE8</accession>
    <name>A0ABM5KWE8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514513.1">
        <property type="nucleotide sequence ID" value="XM_050658556.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658556.1">
        <property type="protein sequence ID" value="XP_050514513.1"/>
        <property type="gene ID" value="LOC126889869"/>
    </dbReference>
    <dbReference type="GeneID" id="126889869"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053308">
        <property type="entry name" value="Vago-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39957">
        <property type="entry name" value="AT09846P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39957:SF1">
        <property type="entry name" value="AT09846P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045474994" description="Single domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Single" evidence="4">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="112" mass="12342" checksum="265C18FAD63C4ADC" modified="2025-10-08" version="1">MKGYLILLIVAITVINVEAWQAIILSDNGTEHLGDCYTTEDGIGSMKLGEQRQLKGECVLLRCSDDRQIIMSGCGVADTEPPCILLPRDFTKDYPECCEQDISCPPEPAAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXJ4</accession>
    <name>A0ABM5KXJ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514918.1">
        <property type="nucleotide sequence ID" value="XM_050658961.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658961.1">
        <property type="protein sequence ID" value="XP_050514918.1"/>
        <property type="gene ID" value="LOC126890114"/>
    </dbReference>
    <dbReference type="GeneID" id="126890114"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="243" mass="28088" checksum="6B03A28B1F235B43" modified="2025-10-08" version="1">MDTWPEDFTKKTGRPPKSFEDLCDRSKRRKTKELREHVPVKELTYAAGVSQPTSGNTDALKIIKDIVSSPTRATKIRKVIKTATKQATIKKHTPEEALAIFVEGDFTRRQWEIIYKSNNSIYPCYSFVQMAKKQCYPDEESIHVTETCSEIRLQALHDHTTLRLHKYLAEVIETCSQEEKQNLTLICKWGCDGSQQTQYKQKFQDSADSDENIFQSSLVPLRLVVLINEKQKKLFGRTQFPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZJ3</accession>
    <name>A0ABM5KZJ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515607.1">
        <property type="nucleotide sequence ID" value="XM_050659650.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659650.1">
        <property type="protein sequence ID" value="XP_050515607.1"/>
        <property type="gene ID" value="LOC114344397"/>
    </dbReference>
    <dbReference type="GeneID" id="114344397"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="3"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="535" mass="60690" checksum="8747207FF444CA81" modified="2025-10-08" version="1">MESPIVTVTEGQVRGCQRVNLDGESFYSFLGIPFAKPPLGDLRFKSPQPVETWNGVRDATKDGQPSYQWDDKNNKPVGSEDCLHLGIHTKKLPSKEPSLKPVMVWIHGGGFIFGSNSSTDYGPEYLMLEDIVLVSVNYRLGFLGCLQFEDTSLNVPGNASLKDQLLALKWIQQNIHHFNGDPKNVTIFGESAGGASIHYLMLSPSSKGLFHRAILQSGCTFCPWSRMTEQNVGLEFAQIVNQNIKTEKEALEVLRKLPANELLEAQQKFNVKYELHLKVAPTIEKPNETAVLTSLPQDLIAKGHYHKIPLMIGYTNMEGILHEIYQQKETKQGLKPDYFNLYKFVHPHMAIENKDPKKELIKEKLKKFYFTENADEMAKYVMATDGTYTAPVVGTAKLHAKAQTEPVYLYLMSLDAGLNFLKRANGFSDMPGACHADDLGYLFQMPLEALNMHRGEKELKAIRIFVKLWTNFAKFGNPTPQGNDMNITWSPVNQEEVNYLDIGDELTMRSNPEPERLKLWREIFQLSPYTQYYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZP0</accession>
    <name>A0ABM5KZP0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515656.1">
        <property type="nucleotide sequence ID" value="XM_050659699.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659699.1">
        <property type="protein sequence ID" value="XP_050515656.1"/>
        <property type="gene ID" value="LOC126890616"/>
    </dbReference>
    <dbReference type="GeneID" id="126890616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="96" mass="10618" checksum="4818842A7B48BAB8" modified="2025-10-08" version="1">MPFCGPKLSLCGLIISAWGIIQLGFMGVFYYIGAVALAEDIPEVEFKGDLDKFYSDVNTGFTQNAYNCWIAALLYLITLAVSAHQFWANNRSSLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0T1</accession>
    <name>A0ABM5L0T1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516047.1">
        <property type="nucleotide sequence ID" value="XM_050660090.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660090.1">
        <property type="protein sequence ID" value="XP_050516047.1"/>
        <property type="gene ID" value="LOC126890921"/>
    </dbReference>
    <dbReference type="GeneID" id="126890921"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46787" checksum="B500B808D8322C07" modified="2025-10-08" version="1">MSEVGEASAKCKTRVHLSDDAKEIIRNVYQTVKEDNPNPEDGKFLIKTTSRLTRMPYTTVWKIVTNRIQPRKKRSDFSTHKAVNEKDAEVIRRAIYNFCSKNLVPTLSMIYDQLVKDYSITYSPSTLSRFLNHIGFRYKKISKQSSIVDSPRLIKWRNEYLDAISKFRDEGRPIFYLDETWFDTHDTAQKGWTDDSIKCAPNYPINRGQRIIILNIGSKNGWLGGESFLLSAKNIKDSKLDYHENMTSSLFKEWFEKKVLPNLPPKSVIVMDNATYHSEQIRKIPSVGSTKKQISDFLYDNDLYFEETYTKKDMLEVLHTKVFEKQFVIDELAKRDGHNVLRLPPYYCVFNPIELIWSQLKESLRRNNCSPKFSSESVSHVVEEIKKISPILWQNCVSHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1K9</accession>
    <name>A0ABM5L1K9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516326.1">
        <property type="nucleotide sequence ID" value="XM_050660369.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660369.1">
        <property type="protein sequence ID" value="XP_050516326.1"/>
        <property type="gene ID" value="LOC126891186"/>
    </dbReference>
    <dbReference type="GeneID" id="126891186"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="683"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="769" mass="87000" checksum="6A4E32F5B73D9B2D" modified="2025-10-08" version="1">MSQEELNEFLMFSPGPSTSGHVATGGDEQPNEDKGEEVNDFGVSLSGKNSTSLRVSSDEKSDLQAGTESNSSVSSSSNMHEHDEQNKSEWPSIWTIDMWERKKEAFPWLGCKNGSLGCTLCSTVSHLGAFKKERTSISKEWCTFAITFNGSSKSAQLTSLRKKIFLHKQSSAHLTAESITAKANEETIENVCDKMNVSNLESTIKVFRSAYYLAKNDRPFSDYSKLLQLQKMNGVDIGVGLHSRFSATEIIDHISHEMKKRITQQVKSISGKISILIDESTSLSDKSTLIVYLKCETSKDLPPNVLFLDLIELPNQTADSIFEALLGCLKKYGFDFEYLKENLVAFACDGASVMLGKKSGIVEKLLQQFPNIVPWHCMNHRIELAVSDSINDVGAINHFQMFMDKLYTLYSKSPKNQRELAECASELDLQLQKVGRILGTRWVSSSFKTVMAVWYGYQALYSHFKKAQEDKNRTTTERAMYGGLIRRLTSTQFLSDLAIMYDILAELTMVSECLQNREATVVYADKLIRRSIAFFECLKEKPGTKTLEAKRAAITGNFCHFPLTSSNKITAINDQQLLSSVINNLKRRLFTTRSSNEPSNKATGNNYDYEKEYESLLSELKVLESNNWPPEKYVGYGEQEIEHLCARFRLNANKIKNSFRDYLENSTTIPKDLNPLINCTKLIPCSSAECERGFSHMNIIISPTRSKLTIEHVSALMFIKLNGPSIQTWKPENYVKAWLRRHRTADDTRTRRANLQPDKEEEDAFAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1Q0</accession>
    <name>A0ABM5L1Q0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516367.1">
        <property type="nucleotide sequence ID" value="XM_050660410.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660410.1">
        <property type="protein sequence ID" value="XP_050516367.1"/>
        <property type="gene ID" value="LOC126891229"/>
    </dbReference>
    <dbReference type="GeneID" id="126891229"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="359" mass="42152" checksum="00DCC627833F9700" modified="2025-10-08" version="1">MEILHVTGQSFNDNTIEEYQFHTYQPYIPGKLGYNDEIRIPIQDLDSFTYPANSYLHIEGRLLTHDNKVITKLKFINNAIAYLFGEIRFELNGVVIDSVCDVGLVSSIKNYLSLNESQSLQLENSGWFPKRGRLETNNEVPKDSVLVDSNGNFNVCIPLRLLSGFFKDFRKIIMNLKMQLLLIRSNDDIDAVVSEDESERPKIDINKLYWEVPHVTPSIRKTLRLNKISHTNQELPIKFRSWQMIEYPVRTSTKMETPRHIIVAFQNNRKSKLTKDMSKFDHCNLKNIKVFLNSERYPYNDLQIDFKTNRFAKLYEMFANFQESYYHMVLNQPICNPHDFKMIAPLIHIDCSRQKEIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L226</accession>
    <name>A0ABM5L226_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516496.1">
        <property type="nucleotide sequence ID" value="XM_050660539.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660539.1">
        <property type="protein sequence ID" value="XP_050516496.1"/>
        <property type="gene ID" value="LOC126891363"/>
    </dbReference>
    <dbReference type="GeneID" id="126891363"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="405" mass="47300" checksum="57CC61B33790C648" modified="2025-10-08" version="1">MEVLHVTGQPYNDTTIQEYQFHAYSPYIPGKLNYNDEIRIPIQDLDAYTLPSTSYLDIEGKLLTHDDKEPTKLKFINNAISFLFRELRYELNGVIIYSVREVGLVSTIKNYLSLNENESILFQNAGWFPKSGNEKIIVDAHGNFNVCIPLRLLSGFFEDFRRIIMNCKQELILIRSNDDVDAIVSIDETERPKVEITKLQWNVAHVSPSMREQLRLNSIAHKNIELPIKFRSWQMIEYPSLNNATRHTWAVKTSTNIETPRHIIIAFQKGRKSKITKDMSKFDHNDLKNIKVFLNSERFPYNDLQIDFDTNKFAQIYEMFGSFQTSYYNLNLNQPIFNPQDFKTKTPLIHIDCSRQKEVIQNGSVVLRIEFETNTPSTTDVSAYCLILHEKEFTYNPLTKIVKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2M7</accession>
    <name>A0ABM5L2M7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516688.1">
        <property type="nucleotide sequence ID" value="XM_050660731.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660731.1">
        <property type="protein sequence ID" value="XP_050516688.1"/>
        <property type="gene ID" value="LOC126891555"/>
    </dbReference>
    <dbReference type="GeneID" id="126891555"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="178" mass="21015" checksum="0C3E1C11B0BC82D0" modified="2025-10-08" version="1">MDLSHPVYPFAVVSANNLEELSISFMLVKNPARCRPNEEADKLSYKCFSVNWYQHNNPSIRFALRMVIMRGNKSTKMSARKILELSFATCAAPQENKYVSCVVYKYHIRERTKTTDVAERIARLKWQWVGHIARDNPEKWTQRLTNWTPRENRRGVGRPQKSWADDIKKRMCVYFVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3H8</accession>
    <name>A0ABM5L3H8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516980.1">
        <property type="nucleotide sequence ID" value="XM_050661023.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661023.1">
        <property type="protein sequence ID" value="XP_050516980.1"/>
        <property type="gene ID" value="LOC126891745"/>
    </dbReference>
    <dbReference type="GeneID" id="126891745"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="640" mass="74311" checksum="0C2617F6507E5771" modified="2025-10-08" version="1">MNFGSNMEINQEASEKTFKIKVENEDTCVGPLDAFKIEIAEEPKREPAYDHAFGYLDSNEFPVKTEVEQGEYKFTPFEDKQTTDEESCSQEENQMKIMDTLYSYHKRTYTDHLIEGKMLNKNVNVETAGHTSYKCEICFKQFTAKSSLKTHLRVHTEEKPFMCEICLKQFSQAGSLKKHLRVHTGEKPYKCEICFKQFSESGSLKRHLRVHTGEKTFKCEICLKKFITTNGMKKHLRVHTGEKPYKCETCFQQFGREGALKTHLRVHTGESPYKCETCFKQFCQAGALKKHLRVHTGEKPYKCEMCFKQFSELGSLKTHLRVHTEEKPFMCEICLKQFSRAGSLKKHLRVHTGEKPYKCEICFKQFSESGSLKTHLRVHTGETPYKCETCLRQFSKASNFRHHLRVHTGEKPFMCEICLKQFSRAGSLKKHLRVHTGEKLYKCEICFKQFSESGSLKTHLRVHTGETPYKCETCFKQFCQAGALKTHLRVHTGETPYKCETCFKQFCQAGALKNHLRVHTGEKPYKCEMCFKQFSELGSLKRHLRVHTGGEKPFKCEICLKQFVTTGEMKNHLRVHTGEKPYKCEICFKRFSKSGHLKTHLKVHTGDKPYQCAICLKQFSEKSNLKVHLRVHTGEKPLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3Q1</accession>
    <name>A0ABM5L3Q1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_050517072.1">
        <property type="nucleotide sequence ID" value="XM_050661115.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517073.1">
        <property type="nucleotide sequence ID" value="XM_050661116.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661115.1">
        <property type="protein sequence ID" value="XP_050517072.1"/>
        <property type="gene ID" value="LOC114337984"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661116.1">
        <property type="protein sequence ID" value="XP_050517073.1"/>
        <property type="gene ID" value="LOC114337984"/>
    </dbReference>
    <dbReference type="GeneID" id="114337984"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06613">
        <property type="entry name" value="STKc_MAP4K3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="11">
        <location>
            <begin position="598"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="949" mass="108274" checksum="E68B8EE3FC31646B" modified="2025-10-08" version="1">MAQGVLSSDISRRNPQDDYELIQRIGSGTYGDVYKAKRLSTNDFAAIKVIKLEPGDDFGIIQQEILMMRDCLHPNIIAYYGSYLRRDKLWICMEYCGGGSLQDIYHITGPLAENQIAYMCRETLLGLQYLHTMGKMHRDIKGANILLTECGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAIGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLKDKEKWSPTFHNFVKIALTKNPKKRPTAEKLLQHAFFQGDMHRRLALELLQKVNNPSHMFADLEPDEDGAVPNVPQRIASRLTSRPKPQNAVLSNSDVDRIDEANNTLQRSDIPTVIVEEKQPQWDLMDIMNNVTSVHNCVEHQNQKCGIGNAFDSLNRENFSQERKAMTGSQLLKMSLRSLLQYIDEELMMRGSYKYHQSDYEQQFWNDMHAIRTDRSRRATLPVQDTDNTVKCDIHAVSPTNHSKEQPFNGSPRRHSSVDEIFGLVTSMNLTGQRQRSLSDSSRTGRTNRDSSREVNGTEEDPNHEGESSDMVTCPPVPPRKHRRRHTPPRPPSNGLPPTPKVHMGACFSKVFNGCPLRIHCTVSWINPDTRDQHILIGAEEGIYNLNLNELHETCIDQLYNRRTVWMYVIKDVLMTLSGKTPQLYRHDLLALQNKQSHRFSLHMNRIPERLVPRKFALTTRVPDTRGTLKCCVARNPYNGYKYLCGATANDIYLMQWYDPLNKFMLLKHVECVLLPNPLHVFEMIITPELEYPIVCVAIRQAYQPNRFKLDLINMNSGASWFHSDELQDMDGTATVIPRRENLDIVNVSQLDKDSILVCYENVIRIVNMQGKMKVNKKQVSELRFGFRIDSIICLPDSVLAFHKHGMQGRSLKNGEVTQEITDTARTYKLLGSDKVVMLESNLLRTGTLTNEEGHDLYILAGHEASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3Q3</accession>
    <name>A0ABM5L3Q3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050517069.1">
        <property type="nucleotide sequence ID" value="XM_050661112.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661112.1">
        <property type="protein sequence ID" value="XP_050517069.1"/>
        <property type="gene ID" value="LOC114337986"/>
    </dbReference>
    <dbReference type="GeneID" id="114337986"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="1327"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1419"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="564"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1255"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1427"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1483" mass="171499" checksum="53D382FF9185A011" modified="2025-10-08" version="1">MSWFNFNDSLNIVKGQISNLANNVLADGEEDQEIKDGDYKQLQELCQQQELEIKKLRKINEELNDRQTQPHNASSNGSWNWAEDSSTTTPHDTISDLRKQIHVLENEKSELLGQLDQLDADNQENLANIMEMKEKLQFQLSDVKENLLKVKKDNKVLAAKEEALKKEVESLQRTEKGEHVEGDNEEVDQKSRELEEANRKLISELEDLKKEKVERLQHTEKAEHVEGHKEEVDQKFIELEEANRKLISEIEELKKEMSILQTSYQTVEKALEDTKTSGESNKNEHLKKLESENKLIYSELKKASEKISAFEKKSIEDEENVQKLAIILETYEEQVRFLKEELEKSRVDREQQLSALNIQVQQLTTEHSEDSNTIKQLEEIVEDNKKYISNLEKENTELKATTIDSSFVKALEDTVENQKKELENHILQKEELKKLNEDLLVKAAGRMDGDLESELEDIQTEHEAQISVLREELEQLRKEESRNIADTQKVENLEEEKLSLTRELKDSQELLQELKHNHEVALESLQQKYVNMITKSLEKFDKSDNILDYQTNLDEDSQELGSCINRIINTIKEQKSKYTELEKRLQDISEEKNTILAEKNEEIKNLLEKSDGLQQEVSANAQAAREFENECNELAKNNELLITELEAYKNHPGLQTISESNEDNMILLETQLENANRRIEDLEKIIDDLERSQMRKDSLEESGSDLENAVKQLSVTESEITSKQKEYQDLLNNFDQLQVEYESLKRELEEVKENLVFTDEENSELKSANEKLKTDNENMEYQLSELNINSDSMKDEIQEYKQKFKMILSENSNIKLQSDENLKKYLDFESKINVLEEKLASEEHDKKALESQVESITEKLKNAKMTETTLKLQLEQKNKELASQAEERYNIEIALDKTNRDVAEFQNNFVELQNQNDKLLIEQEQLRTLKDNDQQRIEELEHLVTDLEKQLEVAKTESVQKVQNVTEDISENIDYNNLKLMLDQTVLEKANLQAELNKLTQIQSQLKETTEKISVLQNQLQEITNSRNELINMVTMKHQENVTYHNEIQKLNQVLIAEAEKYKNLEVQLKAAVSPEDIEAKNNEIEKLTDQNSFLKEKCEVLAKNLLEEQAQTQKLLAERSVPSEKETSLQKKVDRLQAHLIELEEHYTQELLQAEQKNASLKAKVADIEEREKSSSTMYTSVSIRANQQVESLQSQLHTAIAERDSLRKQISDAEDENTKQAAALANLQFVLEQFRKDKEQDVIRETDRIRRHINTEKQVQEDLRKEITNLQAQLEERNQGLLAASRLSDQLESSKKTVVGLKDEVSQLQTKLSKTEEELSNALSSTDGKVDKLLIKNLILGFVTTNNNLNRDQTQILKIIATVLDFNQQEHDKIKLNKPQQGWLSSLLAPNPDQNKMTEESLSRAFIQFLENESKPRVVPSLLDTNTPTPSNSSTKTTNSRAPTPKQTPIVLSEIVLPTFSDFAQNRNSSSILKDVLKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L434</accession>
    <name>A0ABM5L434_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517199.1">
        <property type="nucleotide sequence ID" value="XM_050661242.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661242.1">
        <property type="protein sequence ID" value="XP_050517199.1"/>
        <property type="gene ID" value="LOC114334287"/>
    </dbReference>
    <dbReference type="GeneID" id="114334287"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="55"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="242" mass="28068" checksum="EBB9807A98EBCCFA" modified="2025-10-08" version="1">METLRWSFQIVLSISSKMWKYVCFQFRKCTRKILQHQVIRYDIVPLSPLSKHRLSIVKRKILVLDLDETLVHSHHNGVARQIVRPKMPPDFILDIEIERHPVQFFVHKRPHVSYFLDIVSKWYELVIFTASIQAYGTEVADILDAGKGILSRRFYRQHCTQEIGSYTKDLSTVSDDLSSIFIIDNSPGAYRAYPNNAIAIKSWFSDPTDIALLNLLPLLDALRFTSDVRSVLSRNLHLNKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6F4</accession>
    <name>A0ABM5L6F4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518012.1">
        <property type="nucleotide sequence ID" value="XM_050662055.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662055.1">
        <property type="protein sequence ID" value="XP_050518012.1"/>
        <property type="gene ID" value="LOC126892505"/>
    </dbReference>
    <dbReference type="GeneID" id="126892505"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="202" mass="22955" checksum="9ED1BB1B12212D72" modified="2025-10-08" version="1">MGENTVQPLLRQSEVQRLILKIQRNKEKAAQKVYAPADDYTPSFQCEATSSIQREVVKVVEEVEKEKSLKLEEKILKAGEETKELEEVEELEEVLFSSGVPSLRSVVTAITDDESPCDQTLEEDFQHGVRKALLRQAERLENKLKHILEQDDLFKHVANNVFQYIGQAAEIINEKKKKALADIQHNNELLDLASKSTAKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6Q0</accession>
    <name>A0ABM5L6Q0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518116.1">
        <property type="nucleotide sequence ID" value="XM_050662159.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662159.1">
        <property type="protein sequence ID" value="XP_050518116.1"/>
        <property type="gene ID" value="LOC126892593"/>
    </dbReference>
    <dbReference type="GeneID" id="126892593"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045864067" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="197" mass="22396" checksum="6AE6E2AFCAC5374E" modified="2025-10-08" version="1">MGKQIVVILFAILFNVKMNTARSADDALTKDTGIAQSVAPALILDREQNILYYIGYIFTGTWYQAMLHCNSLNMDLVSIETKQENDFLFNQMKALLGDLSEYQFWSSGTTLPYDKWVWMTSGRPIFYTNWEAGEPNNGPNEHCLEIKYIYKRGLTWNDVKQDVKSHALCEAKITKSVAEMFPQFCNCSSTNSVSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8U1</accession>
    <name>A0ABM5L8U1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050518856.1">
        <property type="nucleotide sequence ID" value="XM_050662899.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662899.1">
        <property type="protein sequence ID" value="XP_050518856.1"/>
        <property type="gene ID" value="LOC126892960"/>
    </dbReference>
    <dbReference type="GeneID" id="126892960"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="97"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="408"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="771"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1046"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="615"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="148392" checksum="FF2112A0F99D4002" modified="2025-10-08" version="1">MEEVKNGEFAEKKLNPLDRSNFITRLFFCWLLPYFVKGYNRELTEDDMYRHRSVHDSSKLGQNLEERWIKHVAKNKNPAYWKVLIGTFGWEMFVLNVFYIIFETVQMAQPFLISKLLMVYQTDPEENIKDIYLYAGLIVATSFLRVILAHRFSFATFQVGMKMRIASCSLIYRKALRLSKSALAETTIGQMVNLLSNDVGRFDQAIIMLQYLYFGPIQALIVMVILYMIVGWTGLLGSIFLLLSIPLQSWLGKKTSQFRQKTALKTDERIRLMNEIISGIQVIKMYTWEYPFAKLVEYVRGNEIKFIRKTSVIRAILMSMAMSLNDVAVAICLVTFVLTGNPLTASYAYTVTSYYRLMGSLTYFFPMGVSQGSEMVISMKRIQKFLQYDEIQSDMYDDTSYIFDNSYIHIKKASTKWLKSQPENILENIDMDVTPGNLTAIVGSVGSGKTTLLHVIMKELELQQGYVNVNGIISYASQEPWLFGGSIRQNILFGEIYDQIKYNEVVRVCALQRDFTLFPHGDRTLVGERGVTLSGGQRARINLARATYKDADIYLLDDPLSAVDTHVGKHIFEECICGYLGSKCVVLVTHQLQYLKNIQNIYLLKNGQVAVSGSYNDIRNSNTDYSKLLAEMEDEEQEIKRKSKAVEVKQEKTEGEALPVLQREGKSTGNISGRVYRKYAKAGGHIFKAFCILCLFILNQAVLSMCQYFVTFWVNIQQWKSSQNISSTIDTRLIGNYTALLEFTTPSPQSIDNTGFANWWLTPVFVSEYTAFYFIALNIIMVLIMNIRSSSFYAWAITASTKIHNMMFENIVYSPMRFFNINPSGRILNRFSKDIGALDEVLPMTFMDTLQIGLQVGAISIVISSLTYWIMIPTICIGILFYVMKIVFLKTSRDVKRVESVTRSPIFTHLTATLQGLTTIRAFKAEEILKTEFDRYQNHHSAAFFMYLGANRTFGFWLDFICVIYIGLVILSLIFVERETFGGNIGLALTQTLALTGTFQWGMRQWSELENQMTSVERVQEYADLKHEEDNYTVEPAATWPDQGKIEFKNMSLQYSPDDPPVLKNLSFVIQPSEKVGIVGRTGAGKSSLIQAVFRLTHIDGSILIDDIDTKSVALKKLRSKISIIPQEPVLFSGTLRNNLDPFDEYKDEVLWNALNQVELKSVVDDLPAGLDSKMAEGGSNFSVGQRQLVCLARAVLRNNKILVLDEATANVDPYTDGLIQKTIRKNFDKCTVLTIAHRINTIMDSDKVLVMDAGRVVEFDHPYTLLQNQNGVFYSLVLQTGKATARTLITIAEENKTMKDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAW0</accession>
    <name>A0ABM5LAW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proclotting enzyme-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519577.1">
        <property type="nucleotide sequence ID" value="XM_050663620.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663620.1">
        <property type="protein sequence ID" value="XP_050519577.1"/>
        <property type="gene ID" value="LOC126893430"/>
    </dbReference>
    <dbReference type="GeneID" id="126893430"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF116">
        <property type="entry name" value="FI16631P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Clip" evidence="7">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="354"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67510" checksum="6F7D276C18D4E2B7" modified="2025-10-08" version="1">MHFRMRYWITFIGRLSILCFLFPLTSEYSNKEFYNLRLNPQSNQRWIRESTFDRAPFNYPGPFPPRSISPHYYPYHPHQQRNVERNFPPYQYRNIDRQYQGLENGDTAAGRHFKPETIYKITETLGALNTVGRYLVNMTRGGENSNSISSDVPSALYTLSKNVLGRNVTDTIAPFVREALPAIVDNDGEESNNDKNPNKIKKYKIDVNNQNSKIDDKKDDNDDPRSCTTPEGTDGYCDDLSNCPQLLLNLGNLRQSLCFKSLFEPGVCCPRTTVLSPVTQSPTTTTFRPPTTSQPVTFAAIYYNTEKPTVVISTTNPLRENSSLLSIPSPLPAVINNFVDPEDCGQPESAKFRVVGGEEALPGRWPWMAAIFLHGSQRSEFWCGGSLITATHVLTAAHCTRDSRQRPFAARQFTVRLGDIDLKREDEPSAPATFKVVEIRAHKQFSRIGFYNDIAILKLDKPARKSKYVIPICLPPPQLKNEKFAGQKTTVVGWGTRYYGGKESTVQRQALLPVWRNEDCNDAYFQPITSNFICAGYSQGGTDACQGDSGGPLMTSWDARWIQVGVVSFGNKCGEPGYPGVYTRVTEYLDWIEENTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAY9</accession>
    <name>A0ABM5LAY9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519599.1">
        <property type="nucleotide sequence ID" value="XM_050663642.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663642.1">
        <property type="protein sequence ID" value="XP_050519599.1"/>
        <property type="gene ID" value="LOC114342588"/>
    </dbReference>
    <dbReference type="GeneID" id="114342588"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="710" mass="79529" checksum="64C4F13B0F13D444" modified="2025-10-08" version="1">MFGSKLRSWMEAVRSRKKQHRKEKQGKSNAASLGQKNNVKWDTNCATVIDGYKENEREVIKSHLLKENQSQSGSSGVSNSRYSANNLSSPESAYSTGYSTDGTSPGAPPDNLLNTTKAPDICHPRIAVLNPIQNPSAANVKNPVQLPNSSKALPNHLKDHRTPIFKKRELDESKFAAPSRVNEKIVGNLSPALGITSPRQRNRIRTNPWLPGATLSPSPVKHGLNKGKAAAKSSKDSPKLRRFLSPALSRKQSLSTSSSSSLSATSIQLEVPRPKSVSDEDCTLNEMMGKYDESYVYEKETDILSDSDPTDCETDIDTGQDGGDEDEPFETELDFIDNGSFLDFEANRADLNTGHCSYYTYDVQRKRSSRRRTQRRNTKSSEKKRKSCSNKKKQSKQVDREKRINPYIDGSKSAGATPVSVRRANCRPISKLALDDCLRKRSNSVGFSNDPINNIDKRDKEADLKYRELISEAEHILRAMKTNGLSPRRVPGPANKRVELLRIAECAKPEVFVKNRPPEDTVISNPFCSKIPSNSGYSCPRFSPKKNHITKFIISNSPVLARKEWEMQAQIYKSPMSCRKLPEDPHTPQHVSLKDRHSEAVRSPKYRKKLTKRVPDSSSDSDEDLRRSFLRVGSCPQSEPVRRKVYNQNGGKTVAFNLSNEGSTRQECTSSSDNLRQQVLLNTIVNLKKNLEDHSASLKQVYRSSNNIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0E4</accession>
    <name>A0A6P7F0E4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114324667</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_028128332.1">
        <property type="nucleotide sequence ID" value="XM_028272531.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7F0E4">
        <property type="interactions" value="1356"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272531.2">
        <property type="protein sequence ID" value="XP_028128332.1"/>
        <property type="gene ID" value="LOC114324667"/>
    </dbReference>
    <dbReference type="GeneID" id="114324667"/>
    <dbReference type="KEGG" id="dvv:114324667"/>
    <dbReference type="InParanoid" id="A0A6P7F0E4"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000011">
        <property type="entry name" value="serine/threonine-protein kinase ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1544"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="2216"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="2529"/>
            <end position="2561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028128332.1"/>
        </source>
    </evidence>
    <sequence length="2561" mass="296501" checksum="E50D1BE65B8AC07A" modified="2020-12-02" version="1">MTTLEETIPAFSMWKMFNETIPAIIKAECWEPSIRRLASIIQSKEYSNILFICAKEVNVTFEQYQEIQKKYKGFTIWLLGQFFYLLGYDKFCKVHDTLIDIQLCILDQLSNTQLHVYDELSKEYKKILNLLVDYCKNAKDKVVLEVFVPQNIEDLNQELNLNQVFMDIQSQDKCNSILLKLMKFVNYILEENFTCYSFDQSTCEILDNLLFLLSECDEELQLQVIEIFIDLAETDSDVLYNSEITPKFLVFSNLFEQFLHKTYKSHNLETKLLERLEKSLQSYLSSKERVKKLFKNIPQICKFLFDITIQNTSFTLSSDTQLLVAENVTEFDRDDIENIEKLTFLNTTLIHSFKQKLNQDIEEMELVSGEIKLYLESTNKTWYMVHKKTMTLLKQLSCPSNCAIIDCMNFFKNMRNSLLSINLTKPQGSKTTLCYFDEIDLLINFIKKYLEHVSRCDKSSKSLEEAFYFMVNCALLTGTKNISLYFHIITFQLLKSFVYKNENQFPVNFLSKNDTGDLKMVFRSFYKYLWTQNTPRSVALKVLNELFVILTSELVIASENQLAEIENLYLKIAKGVMESGNDEDIVFVVENIPHTLILFQEPDKIISQILNPAFTSKNHKVLETILTVLPNILCTVSCDYTKVIWISKKSLQLEILCQKCNLEDNKDISTQELVERKFGKHAVYTNCPKIQIEQKTVSFNLKHVLFLLKEPLDELKMAALNTLPYFSSHVLQFHSVNIIQKWIELASDKNKEIRKRFAQIFGQTVRFCKENLILSEDIKKEILKLTFAKLLIFTKDSLKFSNFELQDTLLSTIESITAIKSDYITLESLKILLYLIMIPTSKYSLIAVNKCFKLAEKNDTSTTTIYSQNKREICEVISHLCCINQALINYNLSTSLEKVSLMFGFYGSKDFVHQESNYLLPFFVSKTVNIPSVSRLIQEMAAMMEMDLAEALSSRYGYIFIHVFLEDIPKEDLKKCMMFLEKSTNASGISLRKRNFRIILNELLLNFHENNSRVLLALRLLSNEDYENKGSSIQDYLHSHFLGVLLYFDSKLISKNSRKDKCLLSLADLFKYMGAKHIMPLRFKIIAMLQTIDYESSPHLTCAVWDAFIKTCEIESLGPQLAVICVSILPLIENCSQEINSILNYLIIENEAHMKNYIPDLFFVNNPKINIEITLVIRKYIELLEKNSLKEKIQRFLKYLTHEAMEVRIQGLRQLKTYLEEDREELDQMILDYNGIDTAIVELVDILTMGCREKDEALKLACGDVLGELGAIEPSHMPRRYARDDRSFCFYINEDPFIVSSLNELIKAFQTEKNTQSMDRHALAIQETLKGYEISPDENSNKQYLWSQFPDSQKEVMLPLLSSRYMIAQEVLASNLPTPIYGSNSGASFQSWLHNWTSSLISCLPHERKELLKVYIPSMKQDKRILMHFLPHILLYALLEGTDRISEKALIEIQTITSSFSKERTLDEKVLNLRPIRIPGVATETPVITPEDVKQMQCTKVIFLLLDFLDRWVREWHWQKGVAGTADQNFQTIKGFQNELCKLQLAKCNYHCGEYPRALMYLEDFIMDHKEELSNNLSFFAEIYAQLEEPDGVDGAMALQQNEPSLEQKILALEVSGKLADATNCYERMLQPLQLRHIQGLAQCYLDLDNVNTALNFVRGALENQPDFGNMLLEMQAEPLWRLGQYDELDTLLKKPDLSESKIWGVQVGRALLHMKNGERNEFRTTLDCLMKQQVFAFGATSLEEGAYKSGYGYISKLHALNELQQVEKLMSDLLISPNNKEYAEKMMKKLLNEWTLRIKVVQESVAIIEPLLCLRRVSLNLAKNVAEEKIPNAVPYLHSLLGECWLLSAKTARSAGMHQQAYTYTLKAEEFAPPTLFLEKAKLHWLREEHEQALFTLKRGLEVLLPEGYSPDMMTREQRKICAEAKLLIATYNDEISNVDIDVNRQNFKESVEMFREWEKSLVCLAHYLDKLFQSYDSSEQDSRGSDIQLQMINYFGKSLQYGTHYIYQSMPRMLSIWFDYGTRLLEVSQSSVKEERKHILLRMTKLIDSFLERLPAYVFLTAFSQLVSRICHPQKEVYIMLKSIIIKLVQQYPQQSLWMIISVIKSSYSVRSKRCAEILCDPRLKTTTLTKLVRDFTSLAEKLIELCNKEIPPDVNTTSVSNLLRALPRLLAKDDFSEIMMPTFKLRKLILPNPDFRKGQHNPFPNAYVYIVGIEDELNVLQSLQRPRKISLKGSDGKRYIYMLKPKDDLRKDFRLMEFNDIVNHLLAREGEARQRRLNIRLYSVAPLNEECGLIEWVPNLVGLRPVLINLYKQRGCAMKTKDLRDACCNLKDSLDRKRDVFSKKLLARHPAILGEWFRKTFADAQSWLTARTAYVRTTAVMSMAGYMLGLGDRHGENIQLDSTCGDVVHVDFNCLFNKGEKFDWPERVPFRLTHNMVSAMGPLGVEGIFRKSCACTLRVLRENSNTLMSIVAPFVYDPLVSWPRHVSSLPSVHNAERTNEEAVDHIKNIELRLKGSVKTRNRTLTMPLSVEGQTNYLIKEAVSIDNLCQMYIGWGAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F3X7</accession>
    <name>A0A6P7F3X7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dynein intermediate chain 3, ciliary-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114326275</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130384.1">
        <property type="nucleotide sequence ID" value="XM_028274583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F3X7"/>
    <dbReference type="FunCoup" id="A0A6P7F3X7">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274583.2">
        <property type="protein sequence ID" value="XP_028130384.1"/>
        <property type="gene ID" value="LOC114326275"/>
    </dbReference>
    <dbReference type="GeneID" id="114326275"/>
    <dbReference type="KEGG" id="dvv:114326275"/>
    <dbReference type="InParanoid" id="A0A6P7F3X7"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000584">
        <property type="entry name" value="Dynein intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF7">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="523"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="573"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028130384.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="70457" checksum="C0B9A8E94FA58B3B" modified="2020-12-02" version="1">MDVSFPYQKKRSEFGRQCLFSDRGPELIDNFPSIRKLYKEFVLKDPVTRYQQCAPVQAEHYLNTMRAEFANVSVNHVEGGWPKDVNIADEEQTKRYRRKIEKDEQFYNIMMNLFKNMDNCILQNNALNIYQQYFSDVEPMPPVKRSSARTVNVYQDPSQPTRPITHISWSPDNQTKLAISYCDLIFQNHVPKQAKVSYIWEVENPNRPLHILKPDDYIVCLEYNQKDPHILASGQFGGQVAVWDVRKGMEPVEVSVKENSFIDPVQNLLWIHSKTGTEFFSASSDGEIKWWDTRKLSEPTDTLILDYAKEEEQQFSKALGVSVLEYEVTIPTRFMVGTEQGTIIFGNRKGKTAIEKMVGKIPNAHMGPIVALQRNPAFPKNFLTIGDWTAKIWTEDCRESSIIWTGFHKCALTDGAWSPTRLSCYFTTRSDGIFDVWDVLQHQKQASLSVRVCEERLNCLKTHDQGRLVAMGNQNGTAYLVELSENLSSLVKNDKMLLTSMLERETKREKILEARNREIRLKLRQAQSDTKQEGQEEQDDREGKEGEEGEEGEGTEFLNKTVRNIETNFYNFVETELEKLKPAEDTRFDETSGRMSDVEDSREGDTIEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4E1</accession>
    <name>A0A6P7F4E1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114324665 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114324665</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128330.1">
        <property type="nucleotide sequence ID" value="XM_028272529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4E1"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272529.2">
        <property type="protein sequence ID" value="XP_028128330.1"/>
        <property type="gene ID" value="LOC114324665"/>
    </dbReference>
    <dbReference type="GeneID" id="114324665"/>
    <dbReference type="KEGG" id="dvv:114324665"/>
    <dbReference type="InParanoid" id="A0A6P7F4E1"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028042088" evidence="2">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028128330.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14523" checksum="9CF7DF81AFBE2112" modified="2020-12-02" version="1">MFILVFVLILSFCSSGVLGRSYYLLDDSQPNDSQSAIAININSSEDESNVNILHHFEDDVLSKLKVPPPPPITEVSILPTETPSHPPSPPMTTSTTTSEPPTPSSTTTPATPTTSKPQPPIIINIKNCIKCIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6D3</accession>
    <name>A0A6P7F6D3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muscle-specific protein 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325204</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129005.1">
        <property type="nucleotide sequence ID" value="XM_028273204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6D3"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273204.1">
        <property type="protein sequence ID" value="XP_028129005.1"/>
        <property type="gene ID" value="LOC114325204"/>
    </dbReference>
    <dbReference type="GeneID" id="114325204"/>
    <dbReference type="KEGG" id="dvv:114325204"/>
    <dbReference type="InParanoid" id="A0A6P7F6D3"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF13">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="17"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129005.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20608" checksum="B70EEBE43762D0BE" modified="2020-12-02" version="1">MPGPSRPLWQVAGKRDPEQEREAQAWIEAVTGMRFPPGVPYEDCLRDGILLCTLMNRLAPGIIQKINTSGGDYKMMDNLNQFQKACVKYGVPDVDLFQTTDLWDRKNIVLVTTTIFALGRTCYKHPEWRGPFLGPRPSEENRRDFSDEQLRAGEAIIGLQAGQNRGATQAGQNFGASRKIILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6L9</accession>
    <name>A0A6P7F6L9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein DPCD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114326350</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPCD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130487.1">
        <property type="nucleotide sequence ID" value="XM_028274686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6L9"/>
    <dbReference type="FunCoup" id="A0A6P7F6L9">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274686.2">
        <property type="protein sequence ID" value="XP_028130487.1"/>
        <property type="gene ID" value="LOC114326350"/>
    </dbReference>
    <dbReference type="GeneID" id="114326350"/>
    <dbReference type="KEGG" id="dvv:114326350"/>
    <dbReference type="InParanoid" id="A0A6P7F6L9"/>
    <dbReference type="OrthoDB" id="10256139at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026224">
        <property type="entry name" value="DPCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921:SF1">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14913">
        <property type="entry name" value="DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02065">
        <property type="entry name" value="PROTEINDPCD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028130487.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="23713" checksum="E43E4495A09C505A" modified="2020-12-02" version="1">MTDWFIRLQKAKKTCIKQRDLKKVRYELEQGQVMVEEYNIQTGVLTRRAWKRLGTLADEEAWDIEIGDPDPTFLNKEECSIKESSGQPCITRRNTRKILEWRIRNLPYPIEIYSVKVDPDEQCLVVRTSNKKYFKKLPVPDLARLGISLDESNVSFTHKFNTLIIVYEKPKQLLEFEKSLYEEIKKIEPKDEGDMPDCRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7K0</accession>
    <name>A0A6P7F7K0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Venom allergen 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114326603</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130822.1">
        <property type="nucleotide sequence ID" value="XM_028275021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7K0"/>
    <dbReference type="FunCoup" id="A0A6P7F7K0">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275021.2">
        <property type="protein sequence ID" value="XP_028130822.1"/>
        <property type="gene ID" value="LOC114326603"/>
    </dbReference>
    <dbReference type="GeneID" id="114326603"/>
    <dbReference type="KEGG" id="dvv:114326603"/>
    <dbReference type="InParanoid" id="A0A6P7F7K0"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034763">
        <property type="entry name" value="P14a_insect"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038921">
        <property type="entry name" value="P14a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027535805" evidence="5">
        <location>
            <begin position="21"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="64"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130822.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="28469" checksum="1031CE94CD8BB515" modified="2020-12-02" version="1">MAKVFKIIYIFTILYSFSSAQTNTDYCSLSCGDSKHTVCLRQDENCGAGPTCGPNYRPIPLTDADRRLILDVHNDLRNKIASGKETTGAQPSASNMKALSYSKELETIAQCHTNKCVFEHDKCRRSAAHGWVGQNLGLRSSTATDNDNEAVIKGAIQSWFDEVKDFNNTWVDSFGYYPTTKVVGHYTQAAWADTTKVGCGLTFYDSGNWNNWFVACNYAPGGNINTQSVYKVGKPASECGASGVNSNYPDLCGPDDILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F7R8</accession>
    <name>A0A6P7F7R8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dehydrogenase/reductase SDR family protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114327215</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131551.1">
        <property type="nucleotide sequence ID" value="XM_028275750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F7R8"/>
    <dbReference type="FunCoup" id="A0A6P7F7R8">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275750.2">
        <property type="protein sequence ID" value="XP_028131551.1"/>
        <property type="gene ID" value="LOC114327215"/>
    </dbReference>
    <dbReference type="GeneID" id="114327215"/>
    <dbReference type="KEGG" id="dvv:114327215"/>
    <dbReference type="InParanoid" id="A0A6P7F7R8"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004825">
        <property type="entry name" value="PRK06181.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="58"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028131551.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35750" checksum="1C2C68DF1C2E8F0A" modified="2020-12-02" version="1">MFHTVGLTIENRMSEAKKLYESLSLVGSVSLAVSLPWIIFRICKALYLQKGLNELFGKVVVITGASSGLGEALAHEFYKKGCQVVLCARRRQELERVRTDLLHSHSTVQTHPPIIIPLDLADIDNLQEQVKKILSITGKIDILINNGGVSHRGNALSTHVDVDMKIMTVNYFGTIALTKAVLVDMDKRKDGQIVFVSSVQGLIGLPERSAYSASKHALQAFSDSLRAEMTASNISVTVVSPGYIKTNLSLNALTGSGASHGEMDSNTENGYSPEYVAKTILKAVAEKKKEIIVAPLLPRVAIFLRNFLPSVFFLVMAKRAKKSSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAF2</accession>
    <name>A0A6P7FAF2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Testis-expressed protein 10 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114326412</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130573.1">
        <property type="nucleotide sequence ID" value="XM_028274772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAF2"/>
    <dbReference type="FunCoup" id="A0A6P7FAF2">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274772.2">
        <property type="protein sequence ID" value="XP_028130573.1"/>
        <property type="gene ID" value="LOC114326412"/>
    </dbReference>
    <dbReference type="GeneID" id="114326412"/>
    <dbReference type="KEGG" id="dvv:114326412"/>
    <dbReference type="InParanoid" id="A0A6P7FAF2"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="4">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028130573.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="73547" checksum="FA603350D2942AEE" modified="2020-12-02" version="1">MGKNHRHKKNLKSDKAKVHLKQSKTKFLPKGLNETKTVYKIKPIVLSQQLVEKSTDAPLSKRNLDIKDLCSRLSHYNENVRYTACEELAKMFKQFSEEIMKNNMSEIILKICSLMTDMIKKVRTAAVKVITVVLEVIPSEKLEPFFKYFSTNMCCAMTSIHQGIQEDSLKFLDCFLVKDCGFISKTSEKLLPDFFRLISKLRSEKNIGQVLTLNLGSKMTTSTWRINVLSRLNLIFELILNNQPSKEQECVYSNAEESNTFPIYKLSFCEALNNPDWSLSYNSGSILDSYLPELIPIFYEIWMEVSPRNKVNKTIYESTDLKDEAAAIFNYIVNSTYLLWKYVQKEHAHLKDIFVSKEATMFLNNLLSGFPYDRSDKEIQLKRVKSNTHQNIDPNCVKENLIICYIYFVLNATFKRNSAKVELESIAAFLSKCLQTKNYINKTNIDHFLEFISICLGEHCSVWKKSNVDARKLLENVINFTHSIEVAETSRIKMISILADFVDNPYLSKSSGYQAWLSFLPKLLLKPKITDVEIEILLLLARKGNVSFLTGLQTNMVCILENLPSLEYSVQKKCYINSNIDVLSTLKWQTAFLFYYMKDITCPELHNLLKHLSSFISKNECNIIKEQLIRCKGNCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEB7</accession>
    <name>A0A6P7FEB7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Harmonin isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Harmonin isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC114328487</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8 9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133149.1">
        <property type="nucleotide sequence ID" value="XM_028277348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133157.1">
        <property type="nucleotide sequence ID" value="XM_028277356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEB7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277348.2">
        <property type="protein sequence ID" value="XP_028133149.1"/>
        <property type="gene ID" value="LOC114328487"/>
    </dbReference>
    <dbReference type="GeneID" id="114328487"/>
    <dbReference type="KEGG" id="dvv:114328487"/>
    <dbReference type="OrthoDB" id="6021951at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000219">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF36">
        <property type="entry name" value="HARMONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028133149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133157.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="85588" checksum="220D6958CEBAB080" modified="2020-12-02" version="1">MMTMEYPISHHKYACSTMSSETLSGSCGSRNNRVRTIRLVKRHSGNVPIGVGGKHGATLGFSIRGGHEHGTGFFVSHVENGSEAHAQGLKVGDQIIRINGFTIEDAIHKEVLQLISNHTHLTLKVRSVGMIPVKDKKTDILSWQIITDTNSCSSRSSPQFIEKNRDVRIQIMVAPRSKLGCGICKGPEWKPGIFVQFTKEGGIAREAGLRPGDQIVQCNNVDFSDIPFNEAVNLMKTSRQLDLLIRKAAASELFPGESSGYNSSASSVTEDQSSSWGDPKRLSIVKEENQHTEERLNQRSFTNSWNLPDWEEEPTEKSVYKPTIINVTESGTTIKNNGIEYASNKLEQNASHLEDHKMPERTDSKVVVEVHRSDEDDSPCGVNGLAKSSSSSSLASKASLTSAASSSLSSAISMELKRRSEKKATKPPEDTSIDEQLQKKKLLRGLSSDQQFQHTKLMNEFKQAHQKMFKTSSLDCTKSNSALGKDTLERLAHKELSQKLSDRLLNLASNENNRPQEVSSPPPPPPPPPSQILPSPTIQSPSVNSSTPPAPKIKPKAPPVPIKRSVLSCYQPPPCPTPDYDTLSLSSTSSTIKPAHVHESVEMDSLESFKMHNPNHVTPKPPGTYFQKRDLCSKLSNGSVASSAGKERPKSVNISIGEYAVVRSPPRKLDFLKNGTLGRKSVGNSPGNLAYELTQTLNKSNLRKRTESMDDLLNTPEIRAQSNGTVRISVSNLAKEFAKSTSDLTEDYEVTSKTGNRIMININQEKMNGVERMSNNTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGI9</accession>
    <name>A0A6P7FGI9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA polymerase iota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114327792</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132303.1">
        <property type="nucleotide sequence ID" value="XM_028276502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGI9"/>
    <dbReference type="FunCoup" id="A0A6P7FGI9">
        <property type="interactions" value="1209"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276502.2">
        <property type="protein sequence ID" value="XP_028132303.1"/>
        <property type="gene ID" value="LOC114327792"/>
    </dbReference>
    <dbReference type="GeneID" id="114327792"/>
    <dbReference type="KEGG" id="dvv:114327792"/>
    <dbReference type="CTD" id="11201"/>
    <dbReference type="InParanoid" id="A0A6P7FGI9"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000003">
        <property type="entry name" value="Polymerase (DNA directed) iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028132303.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="63309" checksum="3A3534DE784FA2B5" modified="2020-12-02" version="1">MEMLKSLEDHSRTIIHIDIDCFYAQVEMIKNPKLQQVPLGIQQKNIIVTTNYIARSQGVNKCVLISEALKQCPNMVLVNGEDLHDYRQKSYEVTALLQNYSRVVERLGLDENFIDVTELVAERLENIIDISTIGHIFGDDSDLCDCGCTRRLQIGTTIAQEIRDKIKSELQLTTSAGIGHNKLLAKIVGSVHKPDQQTVVFPHNGVELMLSLSSVSKIPGIGYTLSEQLKTINIVTVEDLQKTHFTILSDLLGPEKAKLVQTLSFGIDETVVKSSGKPQSIGIEDSCRALSAEKEVREKLEHLLNRLIILLVEDGRLPKTIKLTIRRFDREKKRSSTRETKQCNISPSLFNTLISSQLPENNIKKIMTVIMHLFNKLVDPKKPYHLTLLGLAFTKFLEKPTTGNILTNFIKKDIEVQSVTDIHNNVTSSALCKTVPATLIIPPECDIEPPSKKYKISHSHLDSPTDLPVAALHLSSDAISFDISSTKIPESTDESESSSSAINNNLDIKCPPNVDHSVFQELPSELQNELWEEYKRDQQSEKRFQKNKRFKSNNILNYFTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FID8</accession>
    <name>A0A6P7FID8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC114330525 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC114330525</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5 6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135674.1">
        <property type="nucleotide sequence ID" value="XM_028279873.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135675.1">
        <property type="nucleotide sequence ID" value="XM_028279874.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028135676.1">
        <property type="nucleotide sequence ID" value="XM_028279875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FID8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028279875.2">
        <property type="protein sequence ID" value="XP_028135676.1"/>
        <property type="gene ID" value="LOC114330525"/>
    </dbReference>
    <dbReference type="GeneID" id="114330525"/>
    <dbReference type="KEGG" id="dvv:114330525"/>
    <dbReference type="OrthoDB" id="6423726at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028135674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028135675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028135676.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26051" checksum="2AD100B42B2053DB" modified="2020-12-02" version="1">MGNCINSCLPHQSSAARALRNFNILDNESTAVDFAFLVEENTSSKHEEKRSFFSRLFKKRTNKKRPVLQLVDGLRNAQVPSGYSRLSESQRLPSTGSCTSRDIQLQCLDARALLQRTATSTPASSLDLEWEHETLPASMIHDPSGSSWTALPEDISCCPTTSHTHNSEMNANASDSDWSRVSSANSLEWDNVQNSIQAEGSPPISELDTDTQFLLGEIERLTNKTLEETGKELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJ70</accession>
    <name>A0A6P7FJ70_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcineurin subunit B type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114329960</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135047.1">
        <property type="nucleotide sequence ID" value="XM_028279246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJ70"/>
    <dbReference type="FunCoup" id="A0A6P7FJ70">
        <property type="interactions" value="1881"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642181.1">
        <property type="protein sequence ID" value="XP_050498138.1"/>
        <property type="gene ID" value="LOC126879165"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FJ70"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028135047.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19346" checksum="E75228E37A9C9A76" modified="2020-12-02" version="1">MGNESSLPMELCSNFDADEIRRLGKRFRKLDLDNSGALSIDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVKGDKLSKLRFAFRIYDMDNDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTILFADKDEDGKISFEEFCNVVGNTDIHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FK75</accession>
    <name>A0A6P7FK75_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 184C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114328634</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028133348.1">
        <property type="nucleotide sequence ID" value="XM_028277547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FK75"/>
    <dbReference type="FunCoup" id="A0A6P7FK75">
        <property type="interactions" value="999"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277547.2">
        <property type="protein sequence ID" value="XP_028133348.1"/>
        <property type="gene ID" value="LOC114328634"/>
    </dbReference>
    <dbReference type="GeneID" id="114328634"/>
    <dbReference type="KEGG" id="dvv:114328634"/>
    <dbReference type="InParanoid" id="A0A6P7FK75"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028133348.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48770" checksum="F70C43125BF88269" modified="2020-12-02" version="1">MCSEACIECFSRWRLWIRPLFILLYALAALVFVPLFLVKSLEDGFNKHDQEILIGGIFVWVAIPLSFWEIIQHVIHYVQPKLQKHVIRILWMVPIYAINAWLGLIYPDQSVYVDSIRECYEAFVIYNFMKFLLNYLNMEMDLEANLELKPQVKHIFPLCCLPDWEMGREFVHICKHGILQYTVVRPLTTAISFVCKNFDVYGDGQFKANVAFPYLTAVNNVSQFIAMYCLVMFYKASVAELRPMKPLPKFLCIKAVVFFSFFQGVLIQLAVYFEFIKPGADSPDQGLSLSTRLQNFLICIEMCLAAIAHHYSFSYEQYLMPGSPSRNQSCCSSFLAMWDISDVHTDIREHIGIVSSSISRRIRGRSMYSIPRGEDEYANLVSPRGAHSVPNPGYYQNDSEDIIVNYGTVSSSQTAKVHNNKYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRK2</accession>
    <name>A0A6P7FRK2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="7 15">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114330460</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="7 15"/>
    <dbReference type="RefSeq" id="XP_028135608.1">
        <property type="nucleotide sequence ID" value="XM_028279807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRK2"/>
    <dbReference type="FunCoup" id="A0A6P7FRK2">
        <property type="interactions" value="1546"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279807.2">
        <property type="protein sequence ID" value="XP_028135608.1"/>
        <property type="gene ID" value="LOC114330460"/>
    </dbReference>
    <dbReference type="GeneID" id="114330460"/>
    <dbReference type="KEGG" id="dvv:114330460"/>
    <dbReference type="CTD" id="8813"/>
    <dbReference type="InParanoid" id="A0A6P7FRK2"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="17">
        <location>
            <begin position="41"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028135608.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30960" checksum="0F320C263F58D878" modified="2020-12-02" version="1">MINKLKAIILIVIYTSFVKLIIAQYNMSKEKQAVNSKNKYSILLPTYNEVENLPIILYLIVKYMNRSNCDYEIIVIDDGSPDGTLEAAKQLQKIYGEDKIFLRPREKKLGLGTAYIHGINHATGNFIIIMDADLSHHPKFISQFIEKQQSQDYDVVSGTRYIGDGGVSGWDFKRKLVSRGANFLTQLLLRPGASDLTGSFRLYKKDVLEKLINSCVSKGYVFQMEMIVRARELNYSVGEVPITFVDRVYGESKLGGSEIVQFVRALLYLFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FS31</accession>
    <name>A0A6P7FS31_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114333429</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028139101.1">
        <property type="nucleotide sequence ID" value="XM_028283300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FS31"/>
    <dbReference type="FunCoup" id="A0A6P7FS31">
        <property type="interactions" value="1838"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283300.2">
        <property type="protein sequence ID" value="XP_028139101.1"/>
        <property type="gene ID" value="LOC114333429"/>
    </dbReference>
    <dbReference type="GeneID" id="114333429"/>
    <dbReference type="KEGG" id="dvv:114333429"/>
    <dbReference type="CTD" id="150962"/>
    <dbReference type="InParanoid" id="A0A6P7FS31"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="72"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="9">
        <location>
            <begin position="239"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028139101.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="55809" checksum="B3B05BF9824BB1DD" modified="2020-12-02" version="1">MKITIPDDLKPSIKSYLEELECCKKCVFRYLGYTLYDAGAREVYAGEQNVKTEITDDSESQPPAKKIKTNPCRVCLDTLCTESMENYLTTFPPDFEDYKIPNVLTFVTFPTSMTLREHSMLVALRNKFPNIYADINLCNLEDLKRIFKAASSTLISKKINKVHHHDADFEVNINIKYEDDNKEAAEFNKAYPKASSRLNLAGCLRTMKDDKFKDVFPVPPEIPNRSLSADINYTTKPVYLGGRYLKFSREMGQTPFFVNDVAICVSSVQETIFPAISKVLGCSEDQMVFSASGREDSDTRMLGTGRPFYIQIKQPKFNTITTEQCRIIEKLMLQPDEKVVVVVVKKLKEVFQRDLKLVKEGEQEKRKTYLALCKTLSPDIDETIEQINLFKTPRVIQQKTPIRVLHRRSQLVRERTIYDLKATKVEGESDLFCLELVTQAGTYVKEFVHGDFDRTVPNLSFYTGYLTDVVALDVLGVELEWPPEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWA5</accession>
    <name>A0A6P7FWA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein canopy 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114331764</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137203.1">
        <property type="nucleotide sequence ID" value="XM_028281402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWA5"/>
    <dbReference type="FunCoup" id="A0A6P7FWA5">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281402.2">
        <property type="protein sequence ID" value="XP_028137203.1"/>
        <property type="gene ID" value="LOC114331764"/>
    </dbReference>
    <dbReference type="GeneID" id="114331764"/>
    <dbReference type="KEGG" id="dvv:114331764"/>
    <dbReference type="CTD" id="40084"/>
    <dbReference type="InParanoid" id="A0A6P7FWA5"/>
    <dbReference type="OrthoDB" id="6020060at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028137203.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25344" checksum="14918381D029131A" modified="2020-12-02" version="1">MNNLKMVVFNGYFIILFCTLALVYSESPEEEQGVKYANKCEVCKILAIELESRLEETGKTSEVLETGYSVDDVKPKKKKAYKKSELRLVESLEGVCDRILEYNIHKEREDSTRFAKGQSQTFQTLHGLVDKGVKVELGIPYELWDKPSAEITKLKTQCETLLEENEAAIEDWYFNHQGKLTLKKYLCEDRALKNQEAKCLYEQLKGETGARKSPKKKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G087</accession>
    <name>A0A6P7G087_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19 20">Stearoyl-CoA desaturase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC114332909</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19 20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138493.1">
        <property type="nucleotide sequence ID" value="XM_028282692.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028138494.1">
        <property type="nucleotide sequence ID" value="XM_028282693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G087"/>
    <dbReference type="EnsemblMetazoa" id="XM_050646717.1">
        <property type="protein sequence ID" value="XP_050502674.1"/>
        <property type="gene ID" value="LOC126881966"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646724.1">
        <property type="protein sequence ID" value="XP_050502681.1"/>
        <property type="gene ID" value="LOC126881966"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="16">
        <location>
            <begin position="155"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028138493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028138494.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="50354" checksum="28387216E040736B" modified="2020-12-02" version="1">MIATLTQLSDESQPLVRDPVSKTILTLPKCNGNELPIVSTSNISKEELEKPKETEELEELDELEEVGDANEISDISDISDEEENVENNNNVENIKDDAGENNKNQKPLPNYEKYKFLFWEFETPIIWVSVFFIFLWHALSVYMVCTFPLMDEIPLVLYATVIGGISGFGVTGGAHRYFTHRAYKARLPLKIILLICYSVAGQNTLYDWVRDHRVHHRFSETDADPHNAKRGFFFSHVGWLMMRKHPEVIRKGRMINLKDITEDPWVAFNVKYWFWCKLFCCFIIPSSIPPLLWGESWYHSICAICFVRYVISLNSTWAVNSFAHFFGNKPYDKTIRPSENLAVSLFAMGEGYHNYHHTFPWDYRAAELGQMLNVTTMWINIFEKIGWAYELRAPTSDMIQKITRNRGDGSHLKWGHKVPKTYSCPVATEVRKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G0Q1</accession>
    <name>A0A6P7G0Q1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-binding cassette sub-family F member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114336319</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142464.1">
        <property type="nucleotide sequence ID" value="XM_028286663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G0Q1"/>
    <dbReference type="FunCoup" id="A0A6P7G0Q1">
        <property type="interactions" value="2268"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286663.2">
        <property type="protein sequence ID" value="XP_028142464.1"/>
        <property type="gene ID" value="LOC114336319"/>
    </dbReference>
    <dbReference type="GeneID" id="114336319"/>
    <dbReference type="KEGG" id="dvv:114336319"/>
    <dbReference type="InParanoid" id="A0A6P7G0Q1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000471">
        <property type="entry name" value="ATP-binding cassette, sub-family F (GCN20), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000472">
        <property type="entry name" value="ATP-binding cassette, sub-family F (GCN20), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="372"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="694"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="627"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028142464.1"/>
        </source>
    </evidence>
    <sequence length="921" mass="104279" checksum="B118DE1472F385DC" modified="2020-12-02" version="1">MSKKRGAKKGKNLDDDFEETSSIISEKEKINSKTPKNKTTKKGKKGKDDWSDDEEIEQGKEVNQSEPAESKPVAKKKGKKGKGNKNDDWSDKEEADIKLSDSETESMPVAVKKSAKKNKKKKDDWSDKEVDIQLSESDIEEAPKIVKKSAKKNKKKDDWSDKEDIEIETKLSDSEEELAPAIVKKSAKKNKKNKNQVRDESPDIEEMEAHDEGFKEDDVSEEEIVKPVKQDKKKSKGKESKKDESKVDVEVKEEIKESKEDSPIVEDKVIENGKPEKQNKELENKKDNDVEELTEKISTTQISDDKLDESKEKKLTHKEKKKMKKLQEYEKQMETMLKKGGQGHSELDSNFTVSQTQKTAGQLAAFENAVDIKVENFSISAKGNDLFVNANLLIAQGRHYGLVGPNGHGKTTLLRHVAQRAFDIPPNIDILYCEQEVVADDNTAVETVLAADVKRNDLLAECKKLEAAANSGDLEIQERLNEVYSELKAIGADSAEPRARRILAGLGFDKEMQDRATKNFSGGWRMRVSLARALYIEPTLLLLDEPTNHLDLNAVIWLDNYLQAWKKTLLIVSHDQSFLDNVCNEIIHLDNKKLYYYKGNYSMFKKMHVQKKREMIKEYEKQEKRIKELKSSGSSKKQAEKKQKEALTRKQEKNRTKIQKQEEDTTPTELLQRPKDYLVKFRFPEPPPLQPPVLGLHNTRFAYPGQKPLFVDTDFGIDMSSRVAIVGPNGVGKSTFLKLLTGDLSPDKGENRKNHRLRIGRFDQHSGEHLTAEETPSEYLMRLFDLPYEKARKQLGTFGLASHAHTIKMKDLSGGQKARVALAELCLNAPDVLILDEPTNNLDIESIDALAEAINEYTGGVIIVSHDERLIRETNCSLYVIEDQTINELEGDFDDYRKELLESLGEVINSPSIAANAAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3K6</accession>
    <name>A0A6P7G3K6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein sly1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114337346</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-vital for development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143554.1">
        <property type="nucleotide sequence ID" value="XM_028287753.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506725.1">
        <property type="nucleotide sequence ID" value="XM_050650768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3K6"/>
    <dbReference type="FunCoup" id="A0A6P7G3K6">
        <property type="interactions" value="2532"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650768.1">
        <property type="protein sequence ID" value="XP_050506725.1"/>
        <property type="gene ID" value="LOC114337346"/>
    </dbReference>
    <dbReference type="GeneID" id="114337346"/>
    <dbReference type="KEGG" id="dvv:114337346"/>
    <dbReference type="CTD" id="33434"/>
    <dbReference type="InParanoid" id="A0A6P7G3K6"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.60:FF:000002">
        <property type="entry name" value="Sec1 family domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000002">
        <property type="entry name" value="sec1 family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028143554.1"/>
        </source>
    </evidence>
    <sequence length="627" mass="70780" checksum="30409E3AD502A0C1" modified="2020-12-02" version="1">MTSLRQKQINAIKQMLNLNQPQTKLSASEPVWKVLIYDRIGQDIISPLISVKELREQGVTLFVQLHSDRDPIPEVPAIYFCAATEDNLDRISQDFQRGTYDIYHLNFISPISRDKLEDLASAAIAANSVANIHKVYDQYINFISLEDDLFVLKHQNSDIMSYYSINKGDIKDSEMEAIMNNIVDSLFSVFVTLGTVPIIRSPKGNAAEMVAKKLDKKLRENIFDTRNNLFVSDAQSGNFNFQRPLLIILDRNVDMATSLHHTWTYQALAHDLLDLALNRVTIEESVPTGGARAKSRSCELDSKDKFWSTHKGSPFPTVAEAIQEELEQYKSSEGEVKKLKSSMGIDNENDIALTMVSDNTAKITSAVNSLPQLLEKKRLIDMHTSVATSLLNCIKSRKLDTFFELEEKIMSKAQGLEKLLMDILADPTAGTPEDKLRLFIIYFICTPHISDHDLHKYENALTEAGCDLSPLLYIKRWKSYTKMASGIGNQYEGAGTKTVNMFSKLVSQGSNFVMEGVKNLVIKRHNLPVTKIVDNLMEFKNSSEMEEYFYLDPKQLKLTEIPRNRSAFQEAIVFVVGGGNYIEYQNLVDYAKVKTTAGNAKRISYGSTTFNNAKQFLQQLALLGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5E4</accession>
    <name>A0A6P7G5E4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rac-like GTP-binding protein ARAC8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114334329</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140168.1">
        <property type="nucleotide sequence ID" value="XM_028284367.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506820.1">
        <property type="nucleotide sequence ID" value="XM_050650863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5E4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050650863.1">
        <property type="protein sequence ID" value="XP_050506820.1"/>
        <property type="gene ID" value="LOC114334329"/>
    </dbReference>
    <dbReference type="GeneID" id="114334329"/>
    <dbReference type="KEGG" id="dvv:114334329"/>
    <dbReference type="InParanoid" id="A0A6P7G5E4"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028140168.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21619" checksum="DCBFCA544BA38DE6" modified="2020-12-02" version="1">MMNPKNNTIRITVVGDGDTGKTCMLIVYKDKKFDDRYVPTVFDVYSMLIPINGVEYKVILSDTAGQEEFDKLRRLAYKDVDCFIVTYAVNEKTSFENVFLKWAPELKRFSPKAKIILAGTKMDLRRNHPSHITTEQGEELARDINAHGFIENSSKTMSFIDATFQMAISAVMYNSNYLKVKRESSCICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9C9</accession>
    <name>A0A6P7G9C9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 271-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114339371</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145811.1">
        <property type="nucleotide sequence ID" value="XM_028290010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9C9"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647194.1">
        <property type="protein sequence ID" value="XP_050503151.1"/>
        <property type="gene ID" value="LOC126882319"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G9C9"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Si:cabz01071911.3"/>
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        <property type="entry name" value="Uncharacterized protein"/>
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        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
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        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
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        </source>
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            <dbReference type="PROSITE" id="PS50157"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028145811.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="83188" checksum="C2D5BAA6F5CF0B8A" modified="2020-12-02" version="1">MEFKVEINEKFVEYDPRYFLSSHLDTSTNLGVLKNEPDEDKSGMEFKTEIKNEVLEGEQQYLETHVSTSLDLEKFKNEPEEDSDFSQKNQVEQQTMNKLKPSLNYEDAALKDSACSKEFPAINNLNKTTSIQTEEGLYKCEICFKQLSGAGSLKAHLRVHAGEKPYKCEICFRQFSQKSSLKTHMIVHCAEKPYNCEICFKQFSYKSSLTKHLKIHTGEKPYEYEICLKKIGEADHLKKHLRVHTGEKAYKCDTRPKSLNYEEAALKDSAYSKESPAINNLNKNTSIQTEEGLYKCEICFKQFRVAGSLKLHLRVHSEEKPYKCEICFKQFSQAGNWKSHLRIHTGEKPYECEICSRKFAEADYLRTHLRVHTGEKPYKCELCFTQFSQAGSLNTHLRSHSEEKPYMCEICSKQFGEKHHLQRHLARHTGEKPYKCEICAKQFGEASSLKKHFKLHTGEKPYTCEICLKQCREAGNLKSHLKVHTGEKPYKCEICFKQFARANCCKIHVRKHTGEKPHKCEICSKKFGEECQLKSHLRRHTGEKPYMCEICLKRFGEAARLKEHLSVHTGEKPYRCEICFKQFRVATSLKLHLRVHSGEKPYKCEICFKQFGQASHWKSHLRIHTGEKRYECEICSRKFAEADYLRKHLRVHTGEKPYKCEVCLKQFSQASSLNTHLRSHAKENQYKCDICFKQFSKKTSLKTHLKVHKRKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GA50</accession>
    <name>A0A6P7GA50_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Uncharacterized protein LOC114335652 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18 19 20" type="primary">LOC114335652</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15 16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141711.1">
        <property type="nucleotide sequence ID" value="XM_028285910.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141712.1">
        <property type="nucleotide sequence ID" value="XM_028285911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141713.1">
        <property type="nucleotide sequence ID" value="XM_028285912.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141714.1">
        <property type="nucleotide sequence ID" value="XM_028285913.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141715.1">
        <property type="nucleotide sequence ID" value="XM_028285914.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141716.1">
        <property type="nucleotide sequence ID" value="XM_028285915.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028141717.1">
        <property type="nucleotide sequence ID" value="XM_028285916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GA50"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655214.1">
        <property type="protein sequence ID" value="XP_050511171.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655215.1">
        <property type="protein sequence ID" value="XP_050511172.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655216.1">
        <property type="protein sequence ID" value="XP_050511173.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655217.1">
        <property type="protein sequence ID" value="XP_050511174.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655218.1">
        <property type="protein sequence ID" value="XP_050511175.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655219.1">
        <property type="protein sequence ID" value="XP_050511176.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655220.1">
        <property type="protein sequence ID" value="XP_050511177.1"/>
        <property type="gene ID" value="LOC126887620"/>
    </dbReference>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028141711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028141712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028141713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028141714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028141715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028141716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028141717.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="68825" checksum="E7AD0011FE898267" modified="2020-12-02" version="1">MSRYKSDPNISEYESPRCCTKVLHYTWKTITCLFSHVFLISMVVSYCVLGAFTFEALEVKNEREVKIGVPLIRQNVTRHLWNFTQEMKALDQTKFTIGATQYLKDFEKSLLDKMNKEGWNGEENLEKVQWTRTGALFYSIIVITTIGYGHISPKTSWGKVVTIFYAILGIPLMLLCLSNIGDVMASSFRFLYWRVCCYMCQKKPKRLKRGKSVRSESRGPRPRYGSFRDRRYTKTPRPFEKRFGELGGPHSHSDTELRYLDSVSPRNLTLPRTRTSRFQRNDDKERKVSRTSTVSSPNPQNHTPNTPRGYSLDRKRPTRDVVIEMDPMLLDNTPILFNKYVVGKDGGFTRMIPGKGITPRQMESEKRALSMPPGRRSRSMTRTRKYLEPPGGSSSDEEDLDSLKDGRTSPRSRPRKSTPLRRTGSPNRSGRSARSRSPMPPMNPSPRMMTPLGYGLRSPRYVDDDSDIDFYYSDDPYDVGKPRIRPVPIWLCVFLVVSYILAGAYLFMTWEGWEYLDSAYFCFITLTTIGFGDLVPAKEVSRDNDRAAISIALCSLYLLFGISLLAMSFNLVQEEVISNVKSVAKSLGIIKSDSDDEHEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD41</accession>
    <name>A0A6P7GD41_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114340756</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028147326.1">
        <property type="nucleotide sequence ID" value="XM_028291525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GD41"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645243.1">
        <property type="protein sequence ID" value="XP_050501200.1"/>
        <property type="gene ID" value="LOC126881165"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GD41"/>
    <dbReference type="OrthoDB" id="4788989at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="368"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028147326.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62428" checksum="34228F9742183344" modified="2020-12-02" version="1">MSKMESTVVDHLENNEQFSLTNTKQLEQEITCSHCTRLLNIKPIYTLEEDDGSRTMCGRCLHVVKEFEGTKTRQVAYESLIKFMTFPCAFEKEGCTSILPGEKVLDHELGCFSATVICPANDNGIYKGPECRWSGNAAHFQHHIEEDHKDCILDPPYFDKLPEESKMYFTHVNKKLAVIALIKIDAKNYRSCVFLIGSDMESQFYRYQLELSEGNDADSILLRKGRLQPFGYFESILANKENLLDINLDIIQPTVTQSKARKPVSAKFSIAMKHKKVINQISESLGIKCRIPKSKGLNQIVNNTLDENLLAELVCPVCIEFMVPPIYICESGHSICNRCVELVRICPNCRSSLTKKTRNFTLESVTTRVQYPCKNQEIGCGFLTTSDKIRMHEQNCDLEDSPCVFNCGLKFRKPALFNHVNEEHPDRVLAFNEIHTLDIKSNTKEFIYLLIASGQMFKLTIKVTGGHTSTSINMQQLNENDENLIYRYKFEFVDTSDSRLATCFMGTIQPAGAKPSKLTEVVIPHSIIANSIDDNFLSYRISLSIINLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF76</accession>
    <name>A0A6P7GF76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Putative inorganic phosphate cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114341662</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May be an inorganic phosphate cotransporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148269.1">
        <property type="nucleotide sequence ID" value="XM_028292468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502748.1">
        <property type="nucleotide sequence ID" value="XM_050646791.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502749.1">
        <property type="nucleotide sequence ID" value="XM_050646792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502750.1">
        <property type="nucleotide sequence ID" value="XM_050646793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502751.1">
        <property type="nucleotide sequence ID" value="XM_050646794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF76"/>
    <dbReference type="FunCoup" id="A0A6P7GF76">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646791.1">
        <property type="protein sequence ID" value="XP_050502748.1"/>
        <property type="gene ID" value="LOC114341662"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646792.1">
        <property type="protein sequence ID" value="XP_050502749.1"/>
        <property type="gene ID" value="LOC114341662"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646793.1">
        <property type="protein sequence ID" value="XP_050502750.1"/>
        <property type="gene ID" value="LOC114341662"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646794.1">
        <property type="protein sequence ID" value="XP_050502751.1"/>
        <property type="gene ID" value="LOC114341662"/>
    </dbReference>
    <dbReference type="GeneID" id="114341662"/>
    <dbReference type="KEGG" id="dvv:114341662"/>
    <dbReference type="InParanoid" id="A0A6P7GF76"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000144">
        <property type="entry name" value="Picot, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="57"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028148269.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="55123" checksum="FCB3A969284743B3" modified="2020-12-02" version="1">MVETKYPETKGQQHKVGDDQVNESEYWNSSAKIIPEDENTENATSTNKVPGFGYRHIQIGLLFLMLAIGYAMRVNLSVGIVAMTNGTTTENPDVPWYEWKNKSVVLSSFFWGYICLQIFAGQLGQTYGTKWLAFVSMAVNSTACFIIPFMAEWLGSSGVIACRVVQGLSQGFFFPSVHNILGKWAPLEERAFLSMIAFAGPSFGTIVSLIASGAIASSWAGWPYAFYIFGGLGYVWMLPWAFLAANTPALHPNISKAEKDYIENSLSVKTQVVAPTPWKDIFTSVPVWAFVITMFGQNWGYSTLLTEIPNYLSNIMHFEMKSNSLLSAAPYATSFLLSFVFGAISDFLINRRYFSRVFARKFFNTVGILGPAIALVVLSFLPDSQSTLSIIMLVIAVGINSAAFVGFQINPVDLAPKYSGVLMGIGNGSSNICSILAPLAVQFVVVPETDKSLWRIIFIVAACVYTAAAIIFIIFGSAEVQPWNDKEQNNEKEEKNKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GGQ5</accession>
    <name>A0A6P7GGQ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Forkhead box protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114342365</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028148964.1">
        <property type="nucleotide sequence ID" value="XM_028293163.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028148965.2">
        <property type="nucleotide sequence ID" value="XM_028293164.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GGQ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028293164.2">
        <property type="protein sequence ID" value="XP_028148965.2"/>
        <property type="gene ID" value="LOC114342365"/>
    </dbReference>
    <dbReference type="GeneID" id="114342365"/>
    <dbReference type="KEGG" id="dvv:114342365"/>
    <dbReference type="InParanoid" id="A0A6P7GGQ5"/>
    <dbReference type="OrthoDB" id="9926427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20028">
        <property type="entry name" value="FH_FOXL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047515">
        <property type="entry name" value="FH_FOXL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF411">
        <property type="entry name" value="FORKHEAD BOX PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="11">
        <location>
            <begin position="132"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148965.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028148964.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="37871" checksum="1CA553C5A529286A" modified="2020-12-02" version="1">MIMEEIPEALKLTVSGAGGLNTDHGLSPELLASNLHKVKSEPDVGGYNNILPSLSLTLHGHAMSPVNPFTSIANSTLTGGSTTPGPQTPGVDSNDELRTASNSSCQSPQPQPSSSTATSTSNSSSSTNSQSKPPYSYVALITMAIQSSHLKKATLSEIYQYITSKFPYFERNKRGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPQYEDMFENGNYRRRRRMKRPYRSAQPYPKAFFGDTLSQHGLPLPRNIFTPPTYPPAYSRYDNWLGQTQLASYTTCNTAAYPQQGYPSPAAFSTCSVRQDAATRYPPPYWPPEGDYSPGPHGSPPTDTQLMLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GPV6</accession>
    <name>A0A6P7GPV6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114339362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114339362</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145795.1">
        <property type="nucleotide sequence ID" value="XM_028289994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GPV6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289994.2">
        <property type="protein sequence ID" value="XP_028145795.1"/>
        <property type="gene ID" value="LOC114339362"/>
    </dbReference>
    <dbReference type="GeneID" id="114339362"/>
    <dbReference type="KEGG" id="dvv:114339362"/>
    <dbReference type="InParanoid" id="A0A6P7GPV6"/>
    <dbReference type="OrthoDB" id="6760274at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028145795.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29443" checksum="32CCFC7CDC4964EC" modified="2020-12-02" version="1">MTVTSEGSQYQVAYKRFMDWRKQQNLMNEVIEEKIEVTEEVLLAYFEELSKTLKATTLWKHYSILNTALLFYKGINIANFLSLKKFLKEKYEGYLPNKSKVFTSEEINKFIKEAPDFDHLLAKVILIMGVMCNCHKKELYNMKTHHLKDLESSISVEIPNQKTGTPRKFTMGGQFYKILKKYSDLRPKKGCDTSFFLNYHKGKCTTQKVGINRFGTMGKYIATWLNLENPELYTGHCFRKLSKSAHTIKIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GUJ1</accession>
    <name>A0A6P7GUJ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114342447</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149058.1">
        <property type="nucleotide sequence ID" value="XM_028293257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GUJ1"/>
    <dbReference type="FunCoup" id="A0A6P7GUJ1">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659249.1">
        <property type="protein sequence ID" value="XP_050515206.1"/>
        <property type="gene ID" value="LOC126890372"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GUJ1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="249"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028149058.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="48717" checksum="B86F32ADF6F1EFAA" modified="2020-12-02" version="1">MIWSSRNKFLGRVKATVASGPECGPVAADKGADCWWSPLAAMGCFGNRDAAQTSEDIRSQKRISDQINRQLAKEKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFSDKEKKQKIEDIKKNIRDAIITITGAMSTLSPPVALEKPENQVRVDWIQDCATGPDFDYPPEFYDHTEALWKDRGVQATFDRSNEYQLIDCAKYFLDQVSVIRRPDYTPTEQDILRCRVLTSGIFETLFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLKESLELFKSIWNNRWLRTISVILFLNKQDLLAEKILAGKSKLEEYFSDFLRYQIPVEVANDFNEHPEVFRAKYFIRDEFLRISTASGEGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GXI0</accession>
    <name>A0A6P7GXI0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114348002</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154446.1">
        <property type="nucleotide sequence ID" value="XM_028298645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GXI0"/>
    <dbReference type="FunCoup" id="A0A6P7GXI0">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662108.1">
        <property type="protein sequence ID" value="XP_050518065.1"/>
        <property type="gene ID" value="LOC126892547"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GXI0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028154446.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20428" checksum="91144FED830DC7B5" modified="2020-12-02" version="1">MGLTIAVFNRLFSKKPMRILTVGLDAAGKTTILYKLKLGDEIVTTIPTIGFNVETVEYKNISFTVWDVGGQTRIRKLWKHYFANTDGLIFVVDSNDRDRIAEAEEELHNILGEDEFRDCILLIFANKQDLPNLMSTAELTDKLKLHTLKNRRWYIQATCATQGNGLYEGLDWLSNELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GXV8</accession>
    <name>A0A6P7GXV8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Baculoviral IAP repeat-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114347810</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154279.1">
        <property type="nucleotide sequence ID" value="XM_028298478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GXV8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645018.1">
        <property type="protein sequence ID" value="XP_050500975.1"/>
        <property type="gene ID" value="LOC126880942"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GXV8"/>
    <dbReference type="OrthoDB" id="10037309at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050784">
        <property type="entry name" value="IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044:SF139">
        <property type="entry name" value="DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10044">
        <property type="entry name" value="INHIBITOR OF APOPTOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028154279.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27884" checksum="EEF453D847211A27" modified="2020-12-02" version="1">MNPSYLEYPLIVQRLKSFDEWIPTHPIKPIVLAVAGFYYTGKNDKVLCAICGVVVNKWSVCDIPLYKHKECCLFLAAYKKAQKLLAVDERLKTFPPRYKTAKKLASCGFYYTKEEGLRYITNKDITTYIARLDTFLQQPGPSKPLRLASIKRAAEFGYIQTYVGSDSRVIKADICLIIDVTVKEDIAVNNEVIQNGRLICKICFNNEINTVSLPCGHAAKCLDCSAVVQESCCICRAPIVFTTRLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GYF1</accession>
    <name>A0A6P7GYF1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114342212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114342212</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148805.1">
        <property type="nucleotide sequence ID" value="XM_028293004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GYF1"/>
    <dbReference type="FunCoup" id="A0A6P7GYF1">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293004.2">
        <property type="protein sequence ID" value="XP_028148805.1"/>
        <property type="gene ID" value="LOC114342212"/>
    </dbReference>
    <dbReference type="GeneID" id="114342212"/>
    <dbReference type="KEGG" id="dvv:114342212"/>
    <dbReference type="InParanoid" id="A0A6P7GYF1"/>
    <dbReference type="OrthoDB" id="8192965at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148805.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="21403" checksum="B0F382606C0CC9EF" modified="2020-12-02" version="1">MAEGSYEYECMRAELLGIEKPDYDQFMKKAMEQAKKEIEEEEVDIEHLKEVDLEKEGINRMTGRLDELNNILKKTQSKINRMKASCGSVAGLIKTKIGSFSAQSSFDAEHTDPNEPSCSKATRTEGSGSSSPEEITTPENPQSSENGTSVRKSEIQKALDKDLSALDAMIEKAENAQYAMNHQNKQMKRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H292</accession>
    <name>A0A6P7H292_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Gastrula zinc finger protein XlCGF57.1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114349449</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155629.1">
        <property type="nucleotide sequence ID" value="XM_028299828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H292"/>
    <dbReference type="FunCoup" id="A0A6P7H292">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299828.2">
        <property type="protein sequence ID" value="XP_028155629.1"/>
        <property type="gene ID" value="LOC114349449"/>
    </dbReference>
    <dbReference type="GeneID" id="114349449"/>
    <dbReference type="KEGG" id="dvv:114349449"/>
    <dbReference type="InParanoid" id="A0A6P7H292"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="16">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028155629.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64612" checksum="5F6AD361583FF039" modified="2020-12-02" version="1">MNLENKIINYKNTCRICLKTSENMKNLFTLIIHKDNTSAVEFIRKMTDLKLLYSDTLPSNICSECTQAVFTAFDFVEICLASDARLRTQETRRMLREIEAEALELEDEDPLKCDTPSELEHCSKQDELVKTGKSEERSQIIQEKVNPLPKELQFTTARIKDKYKCDVCKKKFNNKILFNKHKRIHEDNAFKCMTCSLSFSRKLNLKAHLTTHLENKDKKFECKECNKFFVFEYLLKKHELRHSNVKPFPCTSCDKGCLTAESLKRHMRTHDKNYTKCYTCYVCNKSFAYPSFLAEHMKNHTGEKPHICNVCGKGFRQSGALHFHEKIHTGDKPFPCRVCKENFMSRSILKVHMRKHTNERPYVCDVCGISFRQSSDLKIHKKIHTGEKFVLCTVCGKKLSTTGQLTIHLRSHTGEKPFTCSTCNKSFASKTMLATHERIHTGEKPYTCKICDKSFSQSCTLLVHSKIHDKQTTKGRNNAKKEAGKENKIADTGKGNVMKKIADLKKNTLPLEKSQGGEFVVDDIIEIDDDKVNENLQSTSAATQEKNRSSVRPASNRSLPVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IA87</accession>
    <name>A0ABM5IA87_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128429.2">
        <property type="nucleotide sequence ID" value="XM_028272628.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_028128429.2"/>
        <property type="gene ID" value="LOC114324784"/>
    </dbReference>
    <dbReference type="GeneID" id="114324784"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF226">
        <property type="entry name" value="CLAVESIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="100"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128429.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="291" mass="34051" checksum="0FFF17E800EA4B92" modified="2025-10-08" version="1">MNGNSSPEMIENGDPDIAKSMEDSEPKVIENGDPEIAKAMEILLDLIKNSDTKISTDQNYLSRYLYGTDFNAEEAFKKVKASAEHILECPEWYRKDGPLTIKKIIDEGPRVILPDFDKEGRPIFLLKNGKLNPSTMPLYDVIAVDDVWLEAVLSKNPELAGKGLCVIMDIKDQNWRLSKWMQPNNVRQSMKKIENLPFKDYKIHVVNNSWWISLAIKMTWPFLPQRYKDMIKFHFNNMESFYEYIDPKVLPPEYGGTKELTYAEIFEKLYARNDEIFRSYESYRFYEEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IBS2</accession>
    <name>A0ABM5IBS2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA repair protein complementing XP-G cells homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129377.2">
        <property type="nucleotide sequence ID" value="XM_028273576.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273576.2">
        <property type="protein sequence ID" value="XP_028129377.2"/>
        <property type="gene ID" value="LOC114325511"/>
    </dbReference>
    <dbReference type="GeneID" id="114325511"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="775"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="724"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1089"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1130"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1158"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129377.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1351" mass="153810" checksum="21DB9B97ABD8B10D" modified="2025-10-08" version="1">MGVHGLWKLIESSGKPIPLETLENKVLAVDVSIWLHQAIKGFQDHKGAPVPNAHLLGIYHRVCKLLYFKIKPIFVFDGGVPALKRQTIAKRNQYKSKNASEADRLQKQLLSTLLKHTAISKVLSEKTKASLPVIKKSSGKYDNLYAPPTEEFESVLSSSDDDLDESSETTTTDSSPTKQWDLHTIDTTSHYFKSLPLEVKHDILTDLKETRKQNSWGKLHQLPKQSDDFSSYQMKRLLKRKEVQSALDEVSKEMGGMSLSLAELESLLKDQGIKTTNDSNIGKRIASDDKTRYLYIKDIQEEIKKAEKGDAKTKDMPAIVEEEAEDEELKKAIQLSLEEIPSTSKIDHPKIHKKSKADIEEEEELNLAIQLSLEGDQSIQNKKAKSTFLENFNDEDFESDSDDDFVPTPKSKKVFHKKMSSAQNYMMEYSGLTPAEIDRILMTNKKVPSKPTFKNIKLNEMNSNSIKSLQNEKRILAVSETVVDIPETKVEESKQTIKHVDDFKEKSIKTHKEVVEKPDTIHEVEIMSDSGDSNDEQQTIEIGDNKEKSIESRKESIEKSGDIKDEVEVMSDSGDSDDGILRRPIEIVIDPNKIKQDGLDDLFDDIFEKEADDQIGNSITTSNKVKLHEVNVPDLSSKNVEDDHVKDVSIDTSRSESDSYTQEIVDKSEETLDKDDSNTIKMHDVIEEPKDENISTIITDLKTDANKVITTDEEYIQNPSKDDLKISELTVEEMQQLKDTYQREKIDLLKEKSNKERLANNITDQMYQEAQELLELFGVPYVVAPMEAEAQCAFLDEIELTDGTITDDSDIWLFGGKTVYKNFFNQSKYVMEFKSESIEHHFKLSRLQMILLAFLVGSDYTTGIQGVGPVTALEILASFPPAEQHEFTLSHHQVLSGLKEFKSWYLKGKTGGPGRSVLKNKLKNISFADHFPNPQVVEAYLDPKIETSRDPFSWSKPDIIGLTIFAQQKFGWTIKKTEEILNPIIKRLEENHSQKSIKDYFKTKFKVDSLNIEGKVSKRVKSAIDRFGKTQDELIAEEMVQLEKEKRKATGKQSSSKNSKSKSNKHTKKSSKNKEDAKETDIDPVNNQSKDEEANQDTVKEKEINNSHTKRTIKKRKEPNEASHSSEQLNNKKEKLSKETVQNKEGKGKSVPRRKRDKRECDLENSEVEPKTKNKVANKKSQPEGNSRSLDQLEAIKDYENLAVELKNRRKRKNELMKIKIDNPVQKKSKIVPEPVSSVEHIPQELTEDEDIKILKATTSNSARIVNEINRDVSKMLEEKPKSRKAVVPTKSLHTKDVIHQRLRDKSTSLRNKIKAIEVYRKSKLGPGYVPKRKKTVLIPKEDAELSEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ID76</accession>
    <name>A0ABM5ID76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028130256.2">
        <property type="nucleotide sequence ID" value="XM_028274455.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504810.1">
        <property type="nucleotide sequence ID" value="XM_050648853.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274455.2">
        <property type="protein sequence ID" value="XP_028130256.2"/>
        <property type="gene ID" value="LOC114326188"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648853.1">
        <property type="protein sequence ID" value="XP_050504810.1"/>
        <property type="gene ID" value="LOC114326188"/>
    </dbReference>
    <dbReference type="GeneID" id="114326188"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09885">
        <property type="entry name" value="PIN_Smg6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="1529"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
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        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1100"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130256.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1703" mass="196556" checksum="7AD6FC470D945522" modified="2025-10-08" version="1">MRRGKPHQPIYRPGSGPLKKSGNVEETESDSSVLYNPRHNQFENTHVDSSKFRSEGSSQGDRLRDFNRVTSELGDLSLNHEVTKRPKKPDQIRYVPRPIAQQAREQNQSQDMNRNTFAHANGVEKTSDASDTVGHKRMPYSERNQMDQRNNWRHESARQKQMGEGRGVNNGSANSNWNRSRDTRSVEPSGPPSRNYNEKIQSKPPSGRRHSLVGMDQFNNLPPRLQKKYLEENKIKIPPQPPTEENHWDGSSVTFQKNPNYSQMGGAYYTLPMSPASHHHQNLRFGSNTLPGKPRGRGRLNYEQEMPPPGTPFDSMTPDRVRSPASSRPCSPPSVRSPQSRPLTPVNDYSDNRRGQRRQDDMGNKGQDRRDNQRREYGHRRDGKNFPRERDNFNNRENFNRDRDNNRDGYREHYNQRWEDDYREPRQKDRNRDGHNRENHNRDNYNRRDRDPRDPRDNRDNRDNRNNRDHRDVRDNRDNREYRDNREYRDNRDHRRGGGGGHRDRRRDHRRDRDRRSSSKDNYTQPAPSVAPEESWDDPPSIQPAHSIAEVQPQSQARPEQLDFHISSEAINSLIPSMISSTLDWSEEVELQDRLESEYLSDALTRSSSIVSLQEVGGMKSLPVNLNEQPASASKSRRRNRRRSKNRSRVRDGSTSQTRNTNRTRQNSTTSIDSTYDSFKVPRDPYPGSSRRSSRDTRDTSYDRYHSSSRNASRDSSWDRHPQSKGSISGNWREDMERSRKNSDKEGKPTMEDIKNVDANTKKAGVIVLPSQKQEVNPNAAPTLSIEDHPRYPEARKSPGQQKSLYDPNNPTKPILVKSSSVRVSVPGFSDNAESSPPQMYTTDQFGNLRPPWYDENTESFKTCHYPDLLRDIKRADNELQYVVDKGLLLMHWDQVDKLRSFMKEALEYLICKAIKFCQTEKVEQHFWNILYHNIIEVTRKAIKNDPDNKEKYKGFLLYLIDEGTKYFEKLLSVLEETFDFKLNNFLKDNNMASHKGLGLVGMALISAQKLFLFLGDLGRYREEVNETSNYGKCRQWYIKSHEINPKNGKPYNQLAILAVYARRKLDAVYYYMRSLMSSNPAPSARENLISLFEENRKKYEQGEKKRREERLERQRLQMKQKESEDASIAPGSLRKETWIHPEGRRKVYRTSQANIEQNYSDEEDLSALSSVEVNKRFIVSYLHVQGKLITKIGLESFQETAMQMLKEFRALLQHSPVPIPCNRLLQLLALNMYAIDTTQLKDPQLQCQPGYRSELQERALIVSLQMFNLILERCVSTLQDYISSHNDFSHISFPPDANVLLPAVKIWCDWLLCHTGVWNPPPSTQDFKVGSPGDCWSRLATLMNLLEQMDQSQAVSFAKEPQEGCDQVRLPEDSVLSGFTPLLYTADDAVYVKKDIDLESAHFTQRLNKLLFFGTVYLCGVDPPVLKLEIEDEVREYVSVVCTSNSRDSPPNTELRPNNDVLLESFSDNEEEQLDQTITPGASSEVRDLLTRKVELEKRKRSQELHMQRVKKILSQSVVSVHVEVRPKYLVPDTNCFIDHMNGISAIAESHSYTLMVPIVVLSELEGLSRGGKGPAPDSRSALDPQHVKRVADCAREALEFLKNRHASVKCVTTKGAILPSTNFSTEDDTMWDNSFKNDDKILTTCLGLCKGNAQEVSEGEPRNLVREVVLLTEDRNLRVKAYARDVPVRELPDFMRWAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGX2</accession>
    <name>A0ABM5IGX2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132479.2">
        <property type="nucleotide sequence ID" value="XM_028276678.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276678.2">
        <property type="protein sequence ID" value="XP_028132479.2"/>
        <property type="gene ID" value="LOC114327961"/>
    </dbReference>
    <dbReference type="GeneID" id="114327961"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="121"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132479.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="276" mass="32820" checksum="4949164C3138BD06" modified="2025-10-08" version="1">MVSQAKIKSWVIQFLRDQKYGDYQIEFNGKPGKDAGYMRDINFLTVKCAHSNEEKILHIILKHDYFQQRETIKNAFIIETLMYHTVLPTFRSFELRKNVDDVFDSAPKYFYSLQDQNTQVILIENVTNKGYKMHDRRRALDMDHCKLILREYGKLHALSLAFRDQHPEEFRDLCRRFPNIHAIFAAQKDMQEYVESRIEEMVNVLKTNGDVELSVRLQAELEDGFKIEDDEIRAVDEQYVICHGDNWNNNYMFKYSVSIPWVSHELHFSSIMDVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IH40</accession>
    <name>A0ABM5IH40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Enhancer of split mbeta protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028132632.2">
        <property type="nucleotide sequence ID" value="XM_028276831.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276831.2">
        <property type="protein sequence ID" value="XP_028132632.2"/>
        <property type="gene ID" value="LOC114328078"/>
    </dbReference>
    <dbReference type="GeneID" id="114328078"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19741">
        <property type="entry name" value="bHLH-O_ESMB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132632.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22828" checksum="2F0B889CABD9FA1E" modified="2025-10-08" version="1">MPSRFDSRFFTECSRNVLHTMAPVAYTTSELNEEPISRTYQYRKVMKPMLERKRRARINRCLDELKELMVTALQNDGENVSKLEKADILELTVRHLHNLKSHHQLVLPPEQSYADRFRAGFTQCAQEVTQFITTPSDIIDPSAGRKLLQHLGACVRQLDYVSHNFNIQYSQKCGSPQGSPTSKLKCSTPSQASMWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILF7</accession>
    <name>A0ABM5ILF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pupal cuticle protein 20-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135663.2">
        <property type="nucleotide sequence ID" value="XM_028279862.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279862.2">
        <property type="protein sequence ID" value="XP_028135663.2"/>
        <property type="gene ID" value="LOC114330516"/>
    </dbReference>
    <dbReference type="GeneID" id="114330516"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046923565" description="Pupal cuticle protein 20-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135663.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="25178" checksum="747461F9F46677D6" modified="2025-10-08" version="1">MWFTFYNMKLILLTSLVSVVLGGRLDSGYLPPTVGRYTPGIGPFGRALGTFGGVGAPFAGGPVVPGAPFAGAPGAPFAGGPGAPFAGGPGAPLAGGSGGAFGGRGYYGGYYDGYRGGPQIPILRYENNPNRGDGSYNYLYETGNGIVAEERGFLKPLGPEGTQQAEGGFSYTAPDGQRISLQYTADENGFRPVGAHLPTPPPIPDAILRSLEQNRLEEARGGYTDDGQYRSGLNYEGSGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IN98</accession>
    <name>A0ABM5IN98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma-interferon-inducible lysosomal thiol reductase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137101.2">
        <property type="nucleotide sequence ID" value="XM_028281300.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281300.2">
        <property type="protein sequence ID" value="XP_028137101.2"/>
        <property type="gene ID" value="LOC114331680"/>
    </dbReference>
    <dbReference type="GeneID" id="114331680"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045310373" description="Gamma-interferon-inducible lysosomal thiol reductase-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137101.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24131" checksum="C358CCE5CAF12E7D" modified="2025-10-08" version="1">MKGKVINLLVLFSCFWLSEQAQVKVSIYYETLCPDSIAFIKDQFHPTYKDLKDYIDVEFVPYGHASETNITGQWAFTCQHGPAECFGNAFHSCVLALNSDKSKTENFVYCSMSAEDPASLQIIEQCLNKAGLDWKTIKNCYFSNEYVKYLIQNGEKTRAAEDTSFIPTIVLNDKFSQQNQDDAISDFRKLICKTLNNGPNECKEDHINVILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INU5</accession>
    <name>A0ABM5INU5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Basement membrane-specific heparan sulfate proteoglycan core protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137627.2">
        <property type="nucleotide sequence ID" value="XM_028281826.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281826.2">
        <property type="protein sequence ID" value="XP_028137627.2"/>
        <property type="gene ID" value="LOC114332075"/>
    </dbReference>
    <dbReference type="GeneID" id="114332075"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045551692" description="Basement membrane-specific heparan sulfate proteoglycan core protein" evidence="20">
        <location>
            <begin position="32"/>
            <end position="4582"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1298"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1519"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="26">
        <location>
            <begin position="1675"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1894"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="26">
        <location>
            <begin position="2039"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="2255"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="24">
        <location>
            <begin position="2309"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="26">
        <location>
            <begin position="2383"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="2749"/>
            <end position="2840"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="2849"/>
            <end position="2930"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="2940"/>
            <end position="3024"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3034"/>
            <end position="3116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3123"/>
            <end position="3205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3214"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3343"/>
            <end position="3421"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3443"/>
            <end position="3527"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3533"/>
            <end position="3610"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3679"/>
            <end position="3760"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="3770"/>
            <end position="3841"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="3852"/>
            <end position="4033"/>
        </location>
    </feature>
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        <location>
            <begin position="4031"/>
            <end position="4067"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="4070"/>
            <end position="4105"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="4110"/>
            <end position="4285"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="4305"/>
            <end position="4342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="4344"/>
            <end position="4380"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="22">
        <location>
            <begin position="4386"/>
            <end position="4567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="105"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="458"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="3314"/>
            <end position="3353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="105"/>
            <end position="125"/>
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    </evidence>
    <sequence length="461" mass="51029" checksum="AA41748F66ECD10C" modified="2025-10-08" version="1">MIVLPKENIFKGTLPQLVAVLSGTLSAISNGMYYAWTAPLLPILQGPDSPVEINNSQAEWLENSFFLGAFCGVWATMYLVDKIGRKKSMLLASFVMFSGWVVTAVAPKVEYIIAARAFAGAAGDIAFVATPMYIAEIADHKIRGFLSSSVYIMMLIGILLIYSVAPFVPFYVHCILGASFDLTQMIILPFMPETPYYLLSKNKPDDALHSLIRLREKEHDVKKELENIKLAVDRQKAEQGRILDLFVVSSNRRAIFVMALLNTAQHFSGISVFLMNIHIILEAGDSIYLEPRIAAIMFSAIMVIAASVASMTIDKYGRKTLLIFSSLLSGICVLVLAMFFSFKNGGIDTTNYSWIPTVCVMLYALSFKLGLGMVPIVLTAELFPANMKAFGMAIADGFYVGASLLSLQVYQRLTQYFGLEYPFYVFSCFCVIAALSTFIFIPETKGKTLEEIQMILKGNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IT85</accession>
    <name>A0ABM5IT85_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="RefSeq" id="XP_028141202.2">
        <property type="nucleotide sequence ID" value="XM_028285401.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285401.2">
        <property type="protein sequence ID" value="XP_028141202.2"/>
        <property type="gene ID" value="LOC114335204"/>
    </dbReference>
    <dbReference type="GeneID" id="114335204"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141202.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="361" mass="41569" checksum="6C0DE530568ED3A6" modified="2025-10-08" version="1">MDPEKKTANPFVYLDIQFDGLKAGRVVIELYNDQVPKTVENFRKLCTGEKGIGKKGKPLHYKGTKFHKVVSMCMVQTGDIINNNGTNGESIYGEYFEDENFSVTHDKEGIVGMVNNGPNTNQSQFYITTQPCFHLDNTNVAFGKVVKGLNILVEMSDQPRENDKPLGELIIADCGEFKADEPWNIKEDDGTEDKYPPWPDDWEEQDPDVPLMEQTLNNIKSSGNFYFNKQDFARAERKYVKCLRYADWYLSKKKQPTLEKSIRLTLMMNLASAKLKRNKYKETAYLCTEVIKDDPDNGKVYYRRAQAMLGLKEYDRALKDLKTALGLHPNDKNIIQLLSSVKKDKLTYLKREKIFFSKLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IUS4</accession>
    <name>A0ABM5IUS4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAM69 protein-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142700.2">
        <property type="nucleotide sequence ID" value="XM_028286899.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510986.1">
        <property type="nucleotide sequence ID" value="XM_050655029.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510987.1">
        <property type="nucleotide sequence ID" value="XM_050655030.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286899.2">
        <property type="protein sequence ID" value="XP_028142700.2"/>
        <property type="gene ID" value="LOC114336525"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655029.1">
        <property type="protein sequence ID" value="XP_050510986.1"/>
        <property type="gene ID" value="LOC114336525"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655030.1">
        <property type="protein sequence ID" value="XP_050510987.1"/>
        <property type="gene ID" value="LOC114336525"/>
    </dbReference>
    <dbReference type="GeneID" id="114336525"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020519">
        <property type="entry name" value="DIPK2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073:SF7">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="6">
        <location>
            <begin position="164"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142700.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="380" mass="44719" checksum="F6A6C0FA8B5E47BF" modified="2025-10-08" version="1">MTARKKMAKSYYIFFLFLPIILSVSFLAIKQKTVLELCEINKCPFCYGKTLCREITKNKINLEYNRVSDFIYNVFSVKNVYFARYKTKPVVLKKLAHTNELNKFDRDIRDKIINYKALKSELKFKLRGMDEKVPFPPFYVCDDDTFELFFDSFNTTNIKTTYTILSINAEPVLLEMFSKKKYFPVPKLYGTCGRMIVQENFGKSVNNIEKFSWYKRALVAYKILQGVQNFTENHEDFRLYLTDISPDNVVVDEDLNVSFIDMENAIIKKKTNTTEKVHYSNHDIDEYSFSPREICESDRSDHNIYGVCRLLLSKNALWPMMDGGLLHNPPREVTSRHWKLFDAIEACVHSPDEINRFDLSRQILNKLHAILRYARANKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IV42</accession>
    <name>A0ABM5IV42_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143231.2">
        <property type="nucleotide sequence ID" value="XM_028287430.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287430.2">
        <property type="protein sequence ID" value="XP_028143231.2"/>
        <property type="gene ID" value="LOC114337043"/>
    </dbReference>
    <dbReference type="GeneID" id="114337043"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143231.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="475" mass="55509" checksum="0A6D6ED37015EE70" modified="2025-10-08" version="1">MKILKIVECRCILYVLKMKKILLKKYNNIEDNSEVDESSYGKESVLDEYCLDSEDIKIENHELEDVSNENEVEIKKELQEHITGAPQDTTREATKSFNATKVHLETSTSESSYQCEICSKQFTQLGSLKLHLRAHTKEKPYKCEICFKRFSQKGGLNRHTVVHTGEKSYKCEICSRQFTKKSSLKLHMIIHTGETPYKCNICCKQFTQKISLKIHMTIHTGETPYKCEICCKQFNQISNLNTHKRVHTNEKPYKCVICNKQFTQRSNLNIHKRIHTSETPYKCKICNKQFTQIGNLNTHKRIHTSEKPYKCEICNKQFTQICNLNTHKRIHTSEKPYKCEICFKKFSQKGILNKHMAVHTSKKPYKCEICSKKFAIKDSLNVHKRIHTSEKPYKCGICSKQFTQKSSLNLHNMTIHTGERPYQCKICNMQFPKLSALKIHMRFHTGERPYECEICSKQFTTKGNLSTHKIVHTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH52</accession>
    <name>A0ABM5JH52_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050497267.1">
        <property type="nucleotide sequence ID" value="XM_050641310.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641310.1">
        <property type="protein sequence ID" value="XP_050497267.1"/>
        <property type="gene ID" value="LOC126878537"/>
    </dbReference>
    <dbReference type="GeneID" id="126878537"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="506"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="926"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="929"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1074"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1094" mass="123297" checksum="582114D5059A7FB0" modified="2025-10-08" version="1">MRDVSNKASRQVGSNEIWRLERDTFRHVATTLRSLRLDGNRLRAVPQEALALLKHLEVLNIGNNLIPFLNSDSFPPMDNLVVLLMKRNQITEISEDAFANVTSLKVLELDDNFLTHIPSAIAKLSDLQEFSISGNRIKYIEGGLLQKTPALALLELKGNPLIGVDAHAFSFLPRLRKLILSDARELSTFPNLNGTSALEILRLDRAGISSVPESLCSTCPRLKSLDLKSNKLNAVPDLNRCKDMRVLDLASNNIKDIEGRPFRGMYLMHDLLLAHNLIEYIPQDAFYNLSKLQVLDLEDNKISYIHPDSFMPIARIEDLNLGNNIFPHLPSAGLERLLHLKTFNNPNLREFPPPTDFPRIQTLILAYAYHCCAFLPLIPSNPPPAKAKDIIVFPDIEDIDLNFWNSSVDLWPSQQNISQKFGKKFGEIWENIRSDFTYPGNFPSYIEEYAAEDDPTLRIPGEITTGVPGKIQCLPLPGPFLPCQDLFDWWTLRCGVWIVFLCAMLGNGTVVFVLIFSRSKMDVPRFLVCNLAAADFFMGIYLGFLAVVDASTLGEFRMYAIPWQMSAACQLSGFLGVLSSELSVWTLAVITLERNYAITHAMHLNKRLSLKHAGYIMICGWSFAIVMAIMPIFNISDYRKFAVCLPFEISDTVSLAYVVFLMFINGIAFLILMGCYLKMYCAIRGSQAWNSNDSRIAKRMALLVFTDFLCWSPIAFFSLTAAFGLQLISLEQAKVFTVFVLPLNSCCNPFLYAILTKQFKKDCVMICKAIEESRVTRGIGRCRHSSNFSNRQTPANTNSLADRSSREKQEHHVPQCTCNAKLLGDNQNQQKNKKDRKTTTREWLLNKARWLFCVRRPTRHRPRNDQYTYQIAEIQQKQHKRASSVSSSENFSSSRSDSWRHNHHCGIPLRLLDPKRRASSWLITRKTSQDSNLSSSRNDSSGSATTASTSTWRISRSSNSSEPSRGRVKPRLTRQCAIQDESEPPGSPGRLTVRFLTTIPSAAENSMQLEDDQPSVLVNPSPTILVSPAKEREGPLYAILHSTPVAPARRQSIVTLHPAESIRESLASTENEKTTQNNSSHENSSHSTNHCNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK50</accession>
    <name>A0ABM5JK50_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498315.1">
        <property type="nucleotide sequence ID" value="XM_050642358.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642358.1">
        <property type="protein sequence ID" value="XP_050498315.1"/>
        <property type="gene ID" value="LOC126879279"/>
    </dbReference>
    <dbReference type="GeneID" id="126879279"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045907176" evidence="2">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="105" mass="11996" checksum="7AB8C367E496A6FC" modified="2025-10-08" version="1">MKLSFSFCFQVFVLLLAFICLIDTQSHQPKMSRMMRVGRAAAPPPNRGYKKMRIFPRVGRTVPLNEDEKFSLPCTLAVLNYDKSENMEPEDDLEAIVGPPYTNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLW0</accession>
    <name>A0ABM5JLW0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050498920.1">
        <property type="nucleotide sequence ID" value="XM_050642963.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642963.1">
        <property type="protein sequence ID" value="XP_050498920.1"/>
        <property type="gene ID" value="LOC126879742"/>
    </dbReference>
    <dbReference type="GeneID" id="126879742"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="151" mass="16762" checksum="F00090817BF0C422" modified="2025-10-08" version="1">MCNSQQPWAVNSTLAYYGFGAASFSNGIDVSLCCACFLFSFQDQISNKKMIVQVINTGSDLDHNHFDIALPEGVVGIFTEGCHDQWNAPWNGWGDQYGGVHNRDECATLPQALQSGCYFRFDFYQNANNPRMHFDQVQCPAEIVAKSGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JM07</accession>
    <name>A0ABM5JM07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">27 kDa hemolymph protein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498971.1">
        <property type="nucleotide sequence ID" value="XM_050643014.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643014.1">
        <property type="protein sequence ID" value="XP_050498971.1"/>
        <property type="gene ID" value="LOC126879762"/>
    </dbReference>
    <dbReference type="GeneID" id="126879762"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047354728" description="27 kDa hemolymph protein-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="26071" checksum="1CE3CCDF5D85F7FF" modified="2025-10-08" version="1">MPNFLWIFIFFLGLAYARNIQFSVSTNHHRHTRDIISEKFLNNNIDGFILKECKRNNLNVENQSELETALVNMDSCFKRKTIFLSSQSDYLNNMEECSKTPKELVTKCLPNNLKYLPDMYFKSAKALVKLYYKDNSIMQGTPMTDCEQKIMQEDAQTYYANCLLKLKEGNTNNDNLLSKTSLCRTAKEFANCFAETMLNKCKKHSDIETFTQDYVKSQDEICSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPM0</accession>
    <name>A0ABM5JPM0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499885.1">
        <property type="nucleotide sequence ID" value="XM_050643928.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643928.1">
        <property type="protein sequence ID" value="XP_050499885.1"/>
        <property type="gene ID" value="LOC126880170"/>
    </dbReference>
    <dbReference type="GeneID" id="126880170"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="684" mass="80709" checksum="E8C69C09DB7DF338" modified="2025-10-08" version="1">MEVKQEIGEETCKTEIEIEEYNDLDCALLDGFKCEIKEESTRQSTHDTHILDLKKPSINTEIEQHGYKLDPFEENQKTENGNLQEEHKMEITETLIEDSSYEGNDMSRRTEGKTLNKSMKVVTGERSYTCEICFKQFNQSSNLKQHLRVHTGEKPHKCEICFKQFNQSSNLKHHLRVHTGEKPYKCEICFKQFNQSSNLKQHLRVHTGEKPHKCEICFKQFSQAIDLKKHLRVHTGEKPHKCEICFKQFNQSSVLKHHLRVHTGEKPHKCEICFKQFSQSSDLKKHLRVHTGEKPHKCEICFKQFNQSSVLKHHLRVHTGEKPHKCEICFKQFSQSSDLKKHLRVHTGEKPHKCEICFKQFNQSSVLKHHLRVHTGEKPHKCEICFKQFNRSSDLKKHLRVHTGEKPHKCEICFKQFNQSSNLKHHLRVHTGEKPHKCEICFKQFNQSSNLKQHLRVHTGEKPHKCEICFKQFSQAIDLKKHLRVHTGEKSHKCEICFKQFNQSSVLKHHLRVHTGEKPHKCEICFKQFKKSSNLKQHLRVHTGEKPHKCEICFKQFSQSSDLKKHLRVHTGEKPHKCEICFKQFNRSSVLKHHLRVHTGEKPHKCEICFKQFNQSSNLKQHLRVHFGEKPHQCEICFKQFSQAIDLKKHLRVHTGEKPYKCDICFKQFSQAGSLKLHVRTHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRG5</accession>
    <name>A0ABM5JRG5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500532.1">
        <property type="nucleotide sequence ID" value="XM_050644575.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644575.1">
        <property type="protein sequence ID" value="XP_050500532.1"/>
        <property type="gene ID" value="LOC126880598"/>
    </dbReference>
    <dbReference type="GeneID" id="126880598"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="158"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="413" mass="46947" checksum="287C009E594AEC5D" modified="2025-10-08" version="1">MAADSSMYVRGRDGKGLLFHELLEALEEENEMPEYISIFPPEEPPDADTDKDSDFSDEEVAGDTNHLPARILRSQVSVKYSHEIKAADDTNNVSQPSTSRQNNISQPCTSKCPKSAKRPRLNPTTWKSNIFEFSSKVPEPDNEYRPNVEDLLKETVKSPIDAFRCYFTQDIIEHIVRETNSYAGQKLVHNLNATSAEILTFVGVMLLSGYHPLPCRRLYWTVDEDVHTPIVSNAMRRNRFDELMSFIHLADNQCNDGTDRMYKIRPLLDMLNSAFKQITPGPTVSVDESMIPYYGRHGSKQFIRGKPIRFGYKLWVAADPSGYIHHVEPYCGSSTRLPQTGLGQGGDVVIGLIDHMQWKKGHRLYFDNLFTSVALLQELSSREIGGTGTLRENRCNASMKLPEKSVWKKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRW6</accession>
    <name>A0ABM5JRW6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500682.1">
        <property type="nucleotide sequence ID" value="XM_050644725.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644725.1">
        <property type="protein sequence ID" value="XP_050500682.1"/>
        <property type="gene ID" value="LOC114327406"/>
    </dbReference>
    <dbReference type="GeneID" id="114327406"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27304" checksum="9CB10129B2CD7810" modified="2025-10-08" version="1">MDKLLKPDRLDIDSNSTNTTQLWTHWKRTFQNFLEAANVSEDKDKLNLLVNYVNPVVCEAISECTTYTDATVTLEKLYIKQKSEIFALHTLSTRKQQVEESIDQYLLILKHLSKDCNFQTVSADRNKDDYIRDSFIRGLSASNVRERLLESATLTLDQAYNSARSLEMAQQQSDSYIMSNSIVNSITTDNTLQNTAHETDQNNSTSAATFPKCWFCGKSRHTRDRCPAKNHHCSCGLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRY5</accession>
    <name>A0ABM5JRY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500703.1">
        <property type="nucleotide sequence ID" value="XM_050644746.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644746.1">
        <property type="protein sequence ID" value="XP_050500703.1"/>
        <property type="gene ID" value="LOC126880706"/>
    </dbReference>
    <dbReference type="GeneID" id="126880706"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123129" checksum="2BD7C9324BAF95C0" modified="2025-10-08" version="1">MDRSRKLKFQRHTALNDIQSIYDLGSKAVSDHSLRSLFKIRCSELDVIKEEFLKQHTSIINNVLSVPDSDTGDEEKVRELFLDLFYKIKVFDAEFFGSPSESPGSASCASGGAHPSHIRLPRIDLPRFQGSFINFASFIDLYNSIVHNNAALGNVEKFKYLKGCLDGTPLSLILNLPITNDNYQVAYDLIVKRYTNVRRCATAHWDAIMGVQKISAVNSKNLAKLVDTFLENLAALKTLGLPTEHWDFIMFNLLLSKLDVDSIKLFELENKSNQIPSFKKLVAFIETQYIAYDNLDSSIGEGKKSSRAPNNTEPKANSKHQTGDSRHNRSSSSFVTNSSSVCCALCKQSHYLNQCSLFLKKSPKERYQFCKEFSSCFKCLNQANHSVKSCPKSFKCSKCSSHLHNSLLHFERNRSNSQSSSENNSPGTSGIESSPEVSHCAASFVGNKNETKKEILLGTVLVHAIDSKGCKQPLRCLIDSGSMSSFISRKAANRLGWPKTPCSFEVNGLNSMQTKLNQRQISFSIQPRHLESPVFHLEAIITDRVCSDLPSTQIDISAWNYIKNLKLADPKFNCSQSVDLLIGCSIFSKVFLEGKIEDSSLRKFWELENIPEEPVSEPEDVLCETIYRETHSRDVSGKYVVSLPFRESPPCLKDSYDVALNRFISLERRLFRQPGLQKDYSSHMQEYIDLGHMQLVPEGEKTKGKYYIPHHCVVKSESVSTKIRVVYNASQKSPRLGKSLNDYLLVGPNLQQDIVSLLLNFRLNRFALCADIRQMYRNILVVPEHTDYQRVLWRFSSFEEIQEYRLLTVTFGVVSSPYLALRTLQQLVLDEGSRFPKAASLVCNASYIDDFVFGASTLEEAQSLVEELVALLKLGGFELRKWCSNEPKLLSQFPESHINPHSINFDPESNGPSLKILEVPPSLREKSPSEEVKKSLVFVSTREEHFLSCLLENQSSFTSIQRILAFMLRFAHNSRLKRSRRVGPLSAVELESSLIILVRFTQEQYFEDQLQSTSFPKPFRKLGVFLDDNTQCLRVGGRLSQSSLSYEAKHPFLLPKKSRLTTLLVRHYHEKYLHAGFKSTQFLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSF6</accession>
    <name>A0ABM5JSF6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500871.1">
        <property type="nucleotide sequence ID" value="XM_050644914.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644914.1">
        <property type="protein sequence ID" value="XP_050500871.1"/>
        <property type="gene ID" value="LOC114330710"/>
    </dbReference>
    <dbReference type="GeneID" id="114330710"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="248" mass="27650" checksum="0546517D0FB2308C" modified="2025-10-08" version="1">MTDANTSANTSASVDRISVKIPPLWPNDPEIWFLQVENQFTLANITSDATKFNYIVVNLDTAYILEVKDIIVSPPATERLLEHEELGDRRPSQFLRHLQSLAGTTVPDNIVRSLWLGRLPASTQAILATQAKASLSAVAELADIISEAIAPRAQISEASNARESTIEKLTAELAEMKIQLSSLSNAQAQANTYRRNRSNSRRRPYPRDSSYSREHNSDILCWYHYRFGDQAKKCSPPCKHQGNVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JU88</accession>
    <name>A0ABM5JU88_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501503.1">
        <property type="nucleotide sequence ID" value="XM_050645546.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645546.1">
        <property type="protein sequence ID" value="XP_050501503.1"/>
        <property type="gene ID" value="LOC114342471"/>
    </dbReference>
    <dbReference type="GeneID" id="114342471"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF15">
        <property type="entry name" value="RE18252P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="323" mass="37158" checksum="CE46FAAA78EF49B9" modified="2025-10-08" version="1">MSEGGKKEWTTEEICTLIDALREHRNLWYPRDANYKNRIAKVDSHKQIAQLFDTNYLEIARKIKNITSQYLRERRNYKKIKKSGAGQNFIPRWFGYNAMSFMHDKNKPRKGVQIGGEYEESESSDDDPQTETQNSVDIHDLEDEPERCKVENSATPLETDKFCMQNASTSNAPENEFTSKNQPKKKTNRNVEKDNESESTQVFNMMKSVYEKKERDEYDVFGEMVANNIRSLKTEYSRITVQQQITNILFDARRSHLPQSSCTPMPSPSIPSWAVISDNSSASAMSGQKVQVITLSETNDFNPIQGETSILKEAFSSLFQDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUL8</accession>
    <name>A0ABM5JUL8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Gastrula zinc finger protein XlCGF57.1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501632.1">
        <property type="nucleotide sequence ID" value="XM_050645675.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501633.1">
        <property type="nucleotide sequence ID" value="XM_050645676.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645675.1">
        <property type="protein sequence ID" value="XP_050501632.1"/>
        <property type="gene ID" value="LOC126881411"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645676.1">
        <property type="protein sequence ID" value="XP_050501633.1"/>
        <property type="gene ID" value="LOC126881411"/>
    </dbReference>
    <dbReference type="GeneID" id="126881411"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="67376" checksum="DD8F8890E0BBBFB6" modified="2025-10-08" version="1">MEEQEDNYTKSELSNNIKCQTELENDGVNNTEFPVTIKNEFKKEMFLPEDNPTNEDSKDWFNQMNTAIYIENVKHEEIEDDSNLLNCKIFKSEPNIKEEEDVIEANQSQCGSFSEDAHSELNANKCFLEKDTKNLENLFTFDKQYSHYGATVASKIGSKEFSTKSIETHMTVHSIEKPFECEVCFKQFTNNYEVKSHMRLHTEKTFKCELCSKEYLKQYSLKTHMRWHSGETISCQICFKQYTTNYDLKLHMRAHIGGIKERRFTCEVCSKTFINKNTLKRHLRWHTGEAYTCEICSKQFVDYHYFTVHMRFHAGAKPFQCEICSKQLSQKSALKVHMRAHTGEKPFVCEICSKSYMTSTNLKVHMREHHTKELPFECKICSKKCATSSRLKSHMMVHIEKGPFKCRICLKRYKTDKDLQLHIKSHNVEETFTCETCARQFSTDSELKFHSRIHREFKCEVCSKGFFSNKTLKLHMKVHTRELFSCQMCHKQFSTKYNLKIHMRRHTGDRPFPCELCSKRFAKKSELTAHMKWHTRDVLYTCEICNKQFVTKTILTRHMRTHQGENPIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JUX9</accession>
    <name>A0ABM5JUX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501747.1">
        <property type="nucleotide sequence ID" value="XM_050645790.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645790.1">
        <property type="protein sequence ID" value="XP_050501747.1"/>
        <property type="gene ID" value="LOC126881497"/>
    </dbReference>
    <dbReference type="GeneID" id="126881497"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="456" mass="51484" checksum="A7BA31D9F8944CD5" modified="2025-10-08" version="1">MQEISEERSSELQNSQDVINPSNQSKLYSTALTQPNKKFASKNQAILFNSLPNTKIEDYLNAIATKVDPNKILAISRIVNDRICVYFTTEETVTEFLRTDNGTIVINQERIQARKLVTPSEKLIISNVPPSIPHSIIETQLQNFAIHQITPLDFLRIGTTNSLFKHILSFRRYTYISPKNLENIPESILINYEQINYRIYFSLEKQSCYICKEQGHLASQCKKNTNTQTSIENSSPTAQPNYIQNCHPIITDAQPTIHPSQSSQQSTSPQSKETTNTSLFDSNPIQTPIQPDNVEMNNHSQNQPPTPSDTQSSKRAVSEITSPSTSVDQNPFKEPLRKSKKAKTIPEDNKTLAEDLIKCTSSFFQDNSDNGYLTQEELIDFFENAYGSADPLSIAKTYTEDIEGLLNFLTKIHPALTPKYLKSRCTRLKTKINKQLLLSAFSTDHSEYSSDASAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWT8</accession>
    <name>A0ABM5JWT8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 70</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502397.1">
        <property type="nucleotide sequence ID" value="XM_050646440.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646440.1">
        <property type="protein sequence ID" value="XP_050502397.1"/>
        <property type="gene ID" value="LOC114325824"/>
    </dbReference>
    <dbReference type="GeneID" id="114325824"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052628">
        <property type="entry name" value="CFAP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44314:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="127838" checksum="0B33961A5BA986B5" modified="2025-10-08" version="1">MPPKSSKSATEAAKASDTRHSVDDALPEPKYKVINILIENYQNIKPFFPVAEVLTTINHDDKIIGNTTALPILDDDLIPVNQTFSLTINVNNPKELDALVSVPLIFIVTQNQGTIDSSLYSQIQLTKPLQNIPLTKSFDSVISIYEAFTGRKTEISEEAKNKRNKRNKSAKGSEKSKAEKKSRKSQNESKTNSERSSTLKSKSSSLVKSDKPKSAANYDLTSFGICCMDLLPVFYKPSKFSQTLYIKPTVQYTDNKMLSFKAHPTIEVTIFIEEDLDLENSTFLNFTLETIYNVPALMSEEMDYWACIMLPMLNGRKSPLLFTNPATVSTNQQPISKLWPGTTRAYNDANATVYTTPEDHNDLISRFDTNYESYITEESPRLEFVMIKRHLMFRDALTELINHIHVHKKVVLEIYVAPKDKTKKKSPNLFGKSLEFSRKIRKSADSLHLMAILDVAALTYPGVQQVRLAAPITTFTPEEAANGGLDDSFFFPYSKRDSKEPKDREPRENLPKKDNKSVKSSKSSKAKSKEGHYMKDLLPPKPAPPPEPEPSVQVYNEAGKPCFVVVTFEMSNPLVQAKKVEDVQEDLSMLIKEKQKNSDLHPTSMLSKCMSYDYYNELLNAMIFDLNDKFLTFSNENCMKPAECLTRKESSQKIAGRFVEFLKHEGIYESYVHSITKATSLMISKDFQRVNGKDIKEHQQFIGNVFVFLISKMNKTVNHLICHEMEPVTTYKKIDNFFFYAKEAMDTNREEIAEKYFLERICNDSQNACYWFDYGIYLLEKKEDDKAYECMKECLLQQQQHKYGLIVLAALLSNKGHKEDAETCFLNVVTDNPEWCEGWAIFYLFYQKTENYGGMDNTLRMAKKYSDLSAPLDYFSEYEDLVWTSEICPKTVFFRTAMLLLKLRLYSWTELALAQEINTHPGFTHYLLSALCYYKRLYRHALDHLEETMKYYGPNYAASSLAGHCFLGLDRKGEAEKQYYYALESYNRPVYLHLVTVNLAQVLIDKGADQEARNLMLLACKYNPSPYTWYMAGKLYYEQKDFLSAEECFSEANAMDNTYAEIWGYLALVNFKLQRQHEADQCLNHAIKNKLSDEDLLELIKDECSLYNHMCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYD5</accession>
    <name>A0ABM5JYD5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502947.1">
        <property type="nucleotide sequence ID" value="XM_050646990.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646990.1">
        <property type="protein sequence ID" value="XP_050502947.1"/>
        <property type="gene ID" value="LOC126882167"/>
    </dbReference>
    <dbReference type="GeneID" id="126882167"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="431" mass="49129" checksum="1AF06FFD07709E5F" modified="2025-10-08" version="1">MSANQYTIREIVDYQSTHNASSADDENDTASDEEQVPIMYQYEMVGPLERTVKRRGHLPKEAVKILKNWLYEHRFNAYPTEIEKQILSQETNLTVLQISNWFINARRRYLPEMMKREGYDSVHYTITRRRRASSSPRNSSDGNPLVGDGVYYKKPKKMIRFDRVDGETEFEVDADGFVEAKPQQLTMSTPGRKFNPWNPDVHYGLTVNAAERSRPETLQVVQPQQVMQTATPTASSNNPFPSNLVVVKTASGKNIVLKVISQSTEIPKQYLLKSKKSATPVVAPLVEVVNEVPMGNQLSLDEHEVIAGGEEGIMTEEDTEIEGVEELETIEGIEEEEVEEVEGIDESMIEAEDEDLVETDMVAVEEGEEIYMPEEIEEEEEEVFVNEVTLEEEVNEVTIGENEVLIDEETVEEEPPEEYDTVLIKQEIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0K5</accession>
    <name>A0ABM5K0K5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_050503723.1">
        <property type="nucleotide sequence ID" value="XM_050647766.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647766.1">
        <property type="protein sequence ID" value="XP_050503723.1"/>
        <property type="gene ID" value="LOC126882762"/>
    </dbReference>
    <dbReference type="GeneID" id="126882762"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="945" mass="108449" checksum="EBF420DEEC954D92" modified="2025-10-08" version="1">MALSVLEDFVKDLLKENIIQNYTAQRITVREFYNKNYRNVGGMCFYEFNMELWRYWYINSFTTKTIKFDERWINYFALQVGGSSVNKKPFNEQVYINDKKCLLCNVTFDNRNKYVSHVDKQSHQVRLSYAKNKSSFKNNKELKITLIFNGKNYAERKLQVPVKTDMQATVRIQNISKKVINVMDIIKINNLFRDISIQEEFESGVLLKPSGSVDVTMRAYFEHSVSVVYPIVVVTEENKTMKQSFHLVMFEIESLSEFSFLKPNSKTFVNKVPDAFTIFSSEGDIVVPGQRPEEFTSYYKEQLPLNQFKIPRELENTFQVLLTKYPQFGMRVPVLYKTISNILEITPGIDQNNYFTKLEKLLHVEENQLRIDIRNYDTLSTLKVVKGKSLYELEVPGLAEARPSLLRNDKVYIKEKKSDSVKYEGCIHVVLERSVHIGLNHRFNKIFIPNKKFHIEFGFNRRSIRVEKQALFLAHTHGIIPTLYPKEIGIGLLTEVNLAMSNRKLNEEQVLAVKNIVKHRSYPFIIFGPPGTGKTVTIVESVYQIWKNYPKSRILICAPSNAATNEVAVRLRPIIPKTEIFRLLGAAYSQNKLELHGIEDIVNVEHGEFYMPSMQDLLKYRILLTTIVTSARLVNGGVPPNHFSHVFIDESGYATETQTLIPIAGILSNSERNGNVMAQVVLAGDPQQLGPLVHSGFAQHCGYGQSMLQRLIFNQLYSKNENNSFDDRCVTKLVKNYRSHESILKTSSRLFYNNELIAAGNEYTDLFIGSENLVNQKFPVIFHNVEGEDVRDETSPSFFNVQEIEQTVEYVSKLLSTKAKGVAIKQDHIGVITPYRKQVEKLKEAFASKKWNSLLTGSVEQFQGKERLVIIISTVRSKNASKFEHIDKMCDLGFLKNPKRLNVALTRAKALLIVIGNGTVLKTDQNWSSFIQYCSENKSTTGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K259</accession>
    <name>A0ABM5K259_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050504267.1">
        <property type="nucleotide sequence ID" value="XM_050648310.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648310.1">
        <property type="protein sequence ID" value="XP_050504267.1"/>
        <property type="gene ID" value="LOC114328135"/>
    </dbReference>
    <dbReference type="GeneID" id="114328135"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905">
        <property type="entry name" value="NINEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905:SF13">
        <property type="entry name" value="NON-CENTROSOMAL MICROTUBULE ARRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="454"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1205" mass="138537" checksum="D35C38BB9CEFAA77" modified="2025-10-08" version="1">MMDEYGLDPYEQQLLKVFNSHDRENCGSLDREGLTQLCQTLQLDEHGLDLVKCLLKDKRSRVNFTDFKDALLALLGNMQNNKSSVNDDNIEEKSSPDREVSPKFVYGSKKYGRRSRPRNEDIHKLVNEDDKPQSISVQRSNSNTEVSSKKRKTNYRLQRCTSLPTNNDLVIEDKNINSHLISNDTELICTEEMLREAWKKLGVGEDGYLNQTELILVCDAIGLHKLADGVIRQLSDKLTVNCDHKISFQELLTILQQDDTWFEVLNHTIPTKDVELDGSLLHQSSECLFPDSRTFHLVTLGPDGNGMINTDDLIEMWESVGVHSPKELLHELGFNCRMVNILDLADVLDKQTKGITEATRSDFQSPHIALLQASLTLYQSEIKTFKNLLEQMHAEREKLKCHVTDANNRATLLAQEVDDNHSRMEQNTLNQVKLIEQRHSDILKEITAQFTKEKDHITTINQTLEDKISTLEQEVNKLKNDLSIAQKYSLNVEKENQGLSLKIAELERDRSLLSGQIDVLENEKLKLNEMGQEENKVLMAKLSTLQMENAQLKDKNDEMVSEIESLSNKMASMRMKVSSTPTTVNTLDQSMEENISIICEGVGLGAKRRSDYSPSKDNLLFGIGDSSPRLGKIRKFHTKNQDNFEVPFTSSESGFDTEVDCPDSPLCDESSSENEELTRLQSKVAFLEQILKQNGIPVPNTGCESLVANWSTNPEYLYSRVQELEKLIRDIKEAMRTMIEKDNINCDTLKKVSETLEKSFLRNSANSLDAFKLDSPQKDCACASSQTDFIDEFEAKVAQLEAKNKDLCAKCADLENCVELLRNEYEKCEDYWQNKVDEERQMYEAEQKVNSDKLADLIIKMKEYEEQFTDQDLPDGRLPTIEETYHLEKQFTDLEEEFEVYKEESETKLLQKDEEIAFLKEKLTELALKQAKDVAVQVELDTEEIRILNKMQNLSCYVIENTSRYPEEMMPPSPQIQSNASYMNQSLVWNQQGRSDEQSENCKSLPVSWSFDNKTESNGPSTSCSTTSLDKNSTPCTPCRPKRTKKYNKNIYKKNVPEKDDGHRDTDQRTGSGSQNSCPNFGPEQKIVIPLRSFHNLNARRNFLEQRVRSLQVCLQQQKYCHEQMMQHFWHQFSGEQAETHSKLKYYQEKLDQQVRINREQLDKLEKTDMLVKDLYVENSYLIASKQRLEEQRCHMLAHCNSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K418</accession>
    <name>A0ABM5K418_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein 4-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050504939.1">
        <property type="nucleotide sequence ID" value="XM_050648982.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648982.1">
        <property type="protein sequence ID" value="XP_050504939.1"/>
        <property type="gene ID" value="LOC114349326"/>
    </dbReference>
    <dbReference type="GeneID" id="114349326"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="864"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="893"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="966"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="112"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="423"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="738"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="150472" checksum="9F76A067B2CA3920" modified="2025-10-08" version="1">MTSTILVVIFKGCFLFHYNLNARIILFVCIFRYTYDLFKKGLSKTLEVDDLYNPLKIDRSQVLGDNLQRNWDKQLEEAKKTNSKPSLLKSIVMTFWLEYAWLGIYAITTDLVLRLIEPLILENLLDYFKPESQVSKNYALMYAGILVAMNILGVLIANQYYLEVLHSGMRIRASCCTVIYRKGLRTTKTALGETASGKLVNLLSNDVSRFDLVSLFIHQLWLAPLSSLIVMGILYQKTGYAGVVGVVAILVTVPIQSYTGTLSAIYRKQTAFKTDQRVRLLDEIISGIQVIKMYAWEIPFRNIIRIARRNEIKIITKSAYVRATLVVLDLFTTRLALFCTLFTVSLSNEEITASKVFVVFSYFNVLSFTMGRMFSRGVSEMAEVMVAIRRIRDFLLNEEYDPNRTNFAMNGNANSVDDFKEIVSLQNLTVKWNLSFSYNALENINLNISDGQLIGIIGPVGSGKSCLLQTILGELDITEGSMRVRGQISYSSQEPWVFAATVRQNIIFCEEYDKKRYQEVIQACSLEKDFEQFPKGDLTLVGDRGSSLSGGQKARINLARAVYRKAAVYLLDDPLSAVDIHVSKHLYEKCINGYLAKRTRVLVTHQVHYLKDADNIIILNNGRIEDEGTFNFVAKSDNVYAKLLTAEPENVEEKKQDRFKYTRQLSIRSQKDSMASVVSNLSIADSLLSNNIDFKKEEAEKEQEFQVKDLQEKSSKDAVNGSLLFKYMLAGSNTFAVLICVMLYIGTQLAVIGVDYWLSFWVNVEEFRNSTESLNTTPPTFIIPSIELTTYNCLYIYGVLLGALFVLAMTRAFFFYKLAMCSSKKLHASMFDNIITARMRFFDTNPGGRILNRFSKDMGCVDELLPLAILDSSQIILFMFGSLLLIIIVNPDFLILIGALSIVFGFMRQIYLKSSKNIKRLEGIMRSPVFTHLRATIEGLTTIRAFGAQSTLMDEFDHHQDYQSGAWYMFLVSGAAFGFYLECFYSVFFAAMTFSLLLFGEAFNLKGGQVGLAITQATALTKYLQFGMRQSAEVSNQLTSVERVLEYKNLEKEPQPFVPQKPAKDWPQKGQITFKDTCLKYFEGGPLVLKHLDLKIQPKEKVGVVGRTGAGKSSLIQALFRLAPIEGSIKIDDIDTKDISLNDLRLKISIIPQDPVLFSGTLKYNLDPFDEYSDEVLYKAIRDVELKDPANVINRLDNRVMDRGSNYSVGQRQLICLTRAILKNNKVLILDEATANVDPQTDAIIQKTIRRKFSDCTVITVAHRLNTIMDSDKVLVMDAGQISEFDHPHLLLQKKNGIFYSMVAETGKTTAEQLRKIASDSYQKLQAIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K4X4</accession>
    <name>A0ABM5K4X4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505243.1">
        <property type="nucleotide sequence ID" value="XM_050649286.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649286.1">
        <property type="protein sequence ID" value="XP_050505243.1"/>
        <property type="gene ID" value="LOC114333325"/>
    </dbReference>
    <dbReference type="GeneID" id="114333325"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="283" mass="32044" checksum="9FF14E7534267C6D" modified="2025-10-08" version="1">MFKADIKELSSNAYQIYTDASKSTKGTACAIFDPQTIKIPPFWPNDPEIGFLQIENQFTLVNITSDATKFNYIVANLETPYISEVRDIIVSPQATERYVKLKSELIKRLSASQQQKIKRLLEHEELGDRRPFQFLRHLQSLTGTTVPDNIVISLWLGRLPSSTQPILATQAKASLDAVAELADTISEAIAPSAQISEASNARESAIDKLTAELAEIKIQLTSLSQAQAQTNTYRRNRSNSRGRRYPRDRGYSREHNSDILCWYHYQASGKHRGQSMPTKYQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K507</accession>
    <name>A0ABM5K507_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505276.1">
        <property type="nucleotide sequence ID" value="XM_050649319.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649319.1">
        <property type="protein sequence ID" value="XP_050505276.1"/>
        <property type="gene ID" value="LOC126883663"/>
    </dbReference>
    <dbReference type="GeneID" id="126883663"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33173">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33173:SF2">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1310" mass="151080" checksum="60EA94B2141100DD" modified="2025-10-08" version="1">MSEKRAADKPPDQKNSETDNTENRLLTMEYINGLLKSLEAEVPAYLKSLLIYNGFDNLYSLSQFNIDEDIERMECYPRDVLSKVLKGEEKKAMSEGCPAEKTFPKKRRTVTNKSTSRSESGNEGDGFCTPNDGCVSQDEEQVNYAMQHVLNISRSYIDKFSRNEFDKGKISEERLQDVLNNSKNLKVKMDGEFTAKISCPLCTFISSAYSVKNSKTGRKWVISNFLRHYKIHFKDDRTNLTKKLPIKPQKPEIQTTILNFIKKDANKKCDLNQDFEDPRGNLFDLTDPNTDLNYGASTSSGLHLELTTELSQNDSFIDQNYEIHDEAQQNNPNGVFLHYNTDLDTDSPTDNQSSSQLRTIVVNDFSTEEHQGASQVVNDIPVSELEYNPDNSSPLEDFFFLDNVAEINQSNNGSEKVKSPKAKSLFDDSNSRRERSLRILNELPYHQTQITTFLNTINHAIDTNPEVTNTLSILTENQGINKFNYGTKGLLKYLLDSAIRNSKNKSGHTNKFDDGMKRFWLYIFISAGRMSYEILHSNLKNILPSVTTIHRQLEEMNNILEGEVRIEDLKLYLQKRNYPPIIFISEDQTALIKKVQYDSASNQMVGFVAPLQEQTRFPRINKFPVDSVSDIENAFKNKTLAINAYIFMAQPLVDGSPAFCISIFGSDNRFTSEDVYKRWQYLIKEAGKHGITILGFSSDGDTRCLKSMKIISKLSFTSLNPYSPYFQANYNLENPAVFQDTIHISTKLKTRLLNENISMNMGGKRVSIDNIRYIIENYPRDKHLLCKSFLESSDKMNFNAIDKLSSEHVTNMLKEVPNAEATRQYLILTRNILDAFLLKEISVERRVYLIWYSTFFMRIWKAWLKKNGENIQKNFITTNAYTCIEINAHGIILVIEKLRQNGISEAFLPWLYSSQPCEKVFRETRSMSSTFSTMINYTLLDVLRRLKRIQAMHEISTDLGPNFRFPRQENKRLGNNSSVFKVTEFPSTDEMINIIKKAQEDALSDAKKIGMEMNRDCCIEINLPTCDNPEEQEEVQGSIIITDTISKEHEPDLEPDFSNEDREFLEYTSTFNNYDSLHLRDYTGQKKAQKSCLSVTLKDKKTRIIKKSTLIWFFQEKQGRLSTDRLLRVKGMTVKNTHKGLSKKKQFRKKPGQGLQPAGNIKKRKMFRQPHERAHKDSTSESRSESDEISLESETLSEDFSDLEDCHNECTKMPVIQLESYYAVFYDTQWYLGRVINSYSSEKFKVKFLQQDLDTFKWPKKDDIQDVHKEFIFYGPVSLSGTEPFSLKRNDLIAIKQKYKTIKSIKSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5E8</accession>
    <name>A0ABM5K5E8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505404.1">
        <property type="nucleotide sequence ID" value="XM_050649447.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649447.1">
        <property type="protein sequence ID" value="XP_050505404.1"/>
        <property type="gene ID" value="LOC126883780"/>
    </dbReference>
    <dbReference type="GeneID" id="126883780"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="126" mass="14514" checksum="DA3531008D205BEA" modified="2025-10-08" version="1">MFSNKSRNILCKNAVPRLFPSIEDSPNQHSNVDQDDENSFDPVNEEQREELATLPLGGEDSEVVLQKNQQTQTLESVSTYSPKQQAKKDYKAIAKQEFSIKKNCKNYKILENPIIVKTLHWKIINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7U8</accession>
    <name>A0ABM5K7U8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050498896.1">
        <property type="nucleotide sequence ID" value="XM_050642939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506197.1">
        <property type="nucleotide sequence ID" value="XM_050650240.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506266.1">
        <property type="nucleotide sequence ID" value="XM_050650309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506267.1">
        <property type="nucleotide sequence ID" value="XM_050650310.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050507536.1">
        <property type="nucleotide sequence ID" value="XM_050651579.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509312.1">
        <property type="nucleotide sequence ID" value="XM_050653355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509656.1">
        <property type="nucleotide sequence ID" value="XM_050653699.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510275.1">
        <property type="nucleotide sequence ID" value="XM_050654318.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050512267.1">
        <property type="nucleotide sequence ID" value="XM_050656310.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517887.1">
        <property type="nucleotide sequence ID" value="XM_050661930.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517888.1">
        <property type="nucleotide sequence ID" value="XM_050661931.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642939.1">
        <property type="protein sequence ID" value="XP_050498896.1"/>
        <property type="gene ID" value="LOC126879728"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650240.1">
        <property type="protein sequence ID" value="XP_050506197.1"/>
        <property type="gene ID" value="LOC126884304"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650309.1">
        <property type="protein sequence ID" value="XP_050506266.1"/>
        <property type="gene ID" value="LOC126884391"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650310.1">
        <property type="protein sequence ID" value="XP_050506267.1"/>
        <property type="gene ID" value="LOC126884392"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651579.1">
        <property type="protein sequence ID" value="XP_050507536.1"/>
        <property type="gene ID" value="LOC126885151"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653355.1">
        <property type="protein sequence ID" value="XP_050509312.1"/>
        <property type="gene ID" value="LOC126886417"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653699.1">
        <property type="protein sequence ID" value="XP_050509656.1"/>
        <property type="gene ID" value="LOC126886703"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654318.1">
        <property type="protein sequence ID" value="XP_050510275.1"/>
        <property type="gene ID" value="LOC126887016"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656310.1">
        <property type="protein sequence ID" value="XP_050512267.1"/>
        <property type="gene ID" value="LOC126888235"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661930.1">
        <property type="protein sequence ID" value="XP_050517887.1"/>
        <property type="gene ID" value="LOC126892401"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661931.1">
        <property type="protein sequence ID" value="XP_050517888.1"/>
        <property type="gene ID" value="LOC126892402"/>
    </dbReference>
    <dbReference type="GeneID" id="126879728"/>
    <dbReference type="GeneID" id="126884304"/>
    <dbReference type="GeneID" id="126884391"/>
    <dbReference type="GeneID" id="126884392"/>
    <dbReference type="GeneID" id="126885151"/>
    <dbReference type="GeneID" id="126886417"/>
    <dbReference type="GeneID" id="126886703"/>
    <dbReference type="GeneID" id="126887016"/>
    <dbReference type="GeneID" id="126888235"/>
    <dbReference type="GeneID" id="126892401"/>
    <dbReference type="GeneID" id="126892402"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="485" mass="55974" checksum="E90E7CCE77F8E129" modified="2025-10-08" version="1">MPLTCIVVNCGSRSKRDKVSFFAIPKPLKFKHAIHLNELTVKRRKKWIRAIRRADLTESKLKYQKVCSKHFIQGQPAKLEDVNDPDWIPTQNMGYSRGPVKRKQDLERLERVKKRSSTKVSQEDNDTFIENENNTVSESNTTAMYEDSTGTETQTELTSDDIEQMAQQLKFANKKIDELTRRINKTILSFESLETDNPKCLYYTGLNFSVLKSVFDRIKPFIPSSSVTVLDPSQQYLLTLMKMRLNLDFKYLAYQFGISQSTCSTYFNTIISIMYQRFKNSIKWPDREIIKKNMPSCFREVFHDKTTIIIDCFEVFIQKPASYLTQQQTWSNYKHHNTVKFLIGITPQGCISYISKAWGGRTSDKQIVELSGFLDKIEPQDIVIADRGFLIKEFLDVLQAKLVIPAFTKGKKQLLPLELEETRNIAQVRIHVERVIGSIKNKFNIFSEPLPISMLTHVTDGINIVDKIIFIACVLINLCPPIVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K851</accession>
    <name>A0ABM5K851_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050506363.1">
        <property type="nucleotide sequence ID" value="XM_050650406.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650406.1">
        <property type="protein sequence ID" value="XP_050506363.1"/>
        <property type="gene ID" value="LOC126884471"/>
    </dbReference>
    <dbReference type="GeneID" id="126884471"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
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    <sequence length="883" mass="103376" checksum="15F5B527DB404AB2" modified="2025-10-08" version="1">MEIKQETSEKSCKIDNESSVHPLDAFKIEIKEEPKTEVAYEAFDYLDLKAFPVNTKVEQDECKFTPFEFEEKQTTKEESCAQGKIKVEIMETLHSSHKGKYTAQQAEGKILNKNMKFGAGQRSHKCEICFKQFSKTCHLKTHLRVHTGEKPYKCGICLKQFTTRMCLKQHLPTHAVERPHKCEICFKRFSRQNILNNHLRIHTGEIQYKCDICLKQFTTGRYLKQHLIMHTGEKSHKCEICFKQLITASHLKEHLRVHTEEKPYKCELCCKQFNYANSLQNHLRVHTGEKPHKCDICFKQFSEASHLKRHLRIHAGEKLYKCEICFKRFITKGQLKIHLRTHTGEKPYKCEICFKQFNQAGYLKQHVRVHTGEKLHECEICFKQFSQACHLKTHLKVHTGEKPYKCEICCKQFALAITLQNHLRVHTGEKPHKCDICFKQFSVAYNLRIHLRIHTGETPYKCEICFKQFTDKSNLNSHLRVHALEKQYKCEICLKQLSSPNYLKQHLRMHTEEKSHKCEICFKQFSQAWQLKTHLRVHTEEKLYKYKCEICCKQFNQTSSLKTHLRVHTGEKPHKCDICFRQFSQACNLKAHLIIHTGETPYKCEVDFTQFTDKSNLKTHLRVHPLEKPYKCEICCKQFNQATSLKRHLRVHTGEKPHKCDICFKQFSQACNLKTHLRIHTGETPYKCEICFKQFTDESSLKPHLRGHALEKPYKCEICLKQFSQSSSLKTHLRIHTGEKLHKCDICSKQFSQACNLKTHLRIHTGETLYKCEICFKQFTDKSSLKTHLPTHTGERPHKCEICCKQFNQASDLKRHLRVHTGEKPHKCDICFKQFSQACNLKKHLKIHTGETPPSSSSVALELFMSQSLLQNNPSFASVSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K929</accession>
    <name>A0ABM5K929_DIAVI</name>
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        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="EnsemblMetazoa"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <sequence length="255" mass="28402" checksum="A61B12ADFF07462D" modified="2025-10-08" version="1">MTQNKLVESVMDLHTKQRQFSGQLYKYTNVMKGWQYRYFLVDANAGLLHYFLCEGEKPDGTVPRGSVHLAGAVICPSDEDSKTFTVNCASGDMLKLRATDARARQEWVNGLRAVAESHTKAISASSPPLPPREQLAVLDALGCVRSQLQQTEQADSALCRSIESAGSKFFVDPNLLLLKATSAASLHCLTQCMNILQRNQHAQQARTGSLTFLEINPHCGSFHCIYCCCRHGTREYEKHGRSKDSENTQYQQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="12">Protein tumorous imaginal discs, mitochondrial-like</fullName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_050651510.1"/>
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        <property type="protein sequence ID" value="XP_050507467.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
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        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="DnaJ"/>
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        <property type="entry name" value="DnaJ_C"/>
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        <property type="entry name" value="DnaJ_CXXCXGXG"/>
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    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="76"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58681" checksum="D7A6DDCCEB751DDE" modified="2025-10-08" version="1">MGSARTLFGILGSKQILLCSNSQFTTKISRTFLHQCFRCHKSLLLNTWSANNLTQNSLLHKRTFHKSHSFNAARRDYYELLGVGKNASNSDIKKAYYKLAKKYHPDVNKNDPEASKKFQEVSEAYEILGDENKRKQYDTWGATADQMGGMGGGGGHSKGPQGFSQQWQYQSTIDPEELFRKIFGDAFTRGSSHFEDFAESNYGFGEAQEILLRITFTQAARGTTKDVNINVVDNCPKCRGARCEPGTQATKCQFCNGTGMESITTGPFVMRSTCRYCQGSRMYIKHKCTECEGKGSTVQRRKVSIPVPAGIEDGQTVRMSVGNKELFVTFRVDKSDYFKRDGPDVHTEADISVAQALLGGTIRIQGLYEDHTIQVMPGTSSHTRIRLSGKGMKKINGYGHGDHYVVLKIKTPKHLTEKQKALAMAYAELEQDTPGQILGITVKKDGNKTFTTNEKLILLEAIRSVLEGKDKKDTDSTNIDLNNNRKQEVEVNSSKSTVTDSTVKKPDTKETSEDSDVEDTKLKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC87</accession>
    <name>A0ABM5KC87_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zasp-like motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507807.1">
        <property type="nucleotide sequence ID" value="XM_050651850.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651850.1">
        <property type="protein sequence ID" value="XP_050507807.1"/>
        <property type="gene ID" value="LOC126885320"/>
    </dbReference>
    <dbReference type="GeneID" id="126885320"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zasp-like motif" evidence="2">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="562" mass="64213" checksum="10AE2D2B97CD4A72" modified="2025-10-08" version="1">MARLVNKQFNSPIGLYSQQNIQDVLDRESHLLENGAVGIDFNNPDVGKPKNLQNSAVLRMLEEEENRQRNGYGPGSDRLLKPLRAWPPPEYEQKSQLRSSFKDVVIPGVKRVAWPPPHETGQNSPYIEQNPVQTQGGPQYPSQAAGYQNNYQQPKPAPSNQALYQQQRAPLKLDVSQGGSSPLASPLSNQSPQAYRAPTPNKNWASVQSPVHTPNQPAWRQSSPSRFQAAHQPVSQQQFLGQQYSGPSQPNYSPNQGSQQYQPPVNQYQPQQQYQQPQNQYQQPQQQYQAPQHQYQAPQQQYQAPQQQYQPPQQQYQPPQQQYQPPQQQYQPPQNQYQPPQSQNQFSRPTAQAVPFQYPSEQQYQTQSTQQYQYSQQYQSSEQSYQSQPQGYQSVPQSSQVHSVPIQVQRQTSKPVEPPPSTITLRPQAPVSQAPPPVYTSQPATATLKVYVNPKNLRGDLKWPPEDVKQKMYEEAENLNTSNSFLSIQGGKHLRGDMKWPPENVKVQAEEENRLRLELAKGPVCRPRKVHRDYTEFFDQHALNSSYPGYKIPPGTQFYRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCG0</accession>
    <name>A0ABM5KCG0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507870.1">
        <property type="nucleotide sequence ID" value="XM_050651913.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651913.1">
        <property type="protein sequence ID" value="XP_050507870.1"/>
        <property type="gene ID" value="LOC126885356"/>
    </dbReference>
    <dbReference type="GeneID" id="126885356"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058586">
        <property type="entry name" value="Ajm-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038825">
        <property type="entry name" value="Apical_junction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26649">
        <property type="entry name" value="Ajm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Apical junction molecule ajm1 alpha/beta" evidence="6">
        <location>
            <begin position="110"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41677" checksum="C24CE385ED87050F" modified="2025-10-08" version="1">MKTPGMIQKNDLRETVSANTSPCHKPHEENSSEQYRRRSEGSEPASDSNSRRASFNSSPVLRCRYARCGKTVIISSAEANGFKNCHNCSYTYCSRACRRAHWEKHRKTCLFSRIGSLCRQVIAACKEKKDTLCHLSQMARRGYLSHGIGAVKCFFPNPESAEQFLSKGLPNLGELTYVRWQDLLPSEMGPQLYAELVKMCKNYNPDSKLVLYVSICVISESPATGSVKWERQLVSRCGKMRLSKDVQIPEREPTESTETLILTSAPIEADPFTVKEIREKAVDNLKNHLKSRGVSLKRHQPEIHKQLLEYCSNVSTKFTPVTMYPKDNISGKNLMCILMLDANEESVKEVENAGVKVRTVNLLDDTCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCG1</accession>
    <name>A0ABM5KCG1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor IF-3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507874.1">
        <property type="nucleotide sequence ID" value="XM_050651917.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651917.1">
        <property type="protein sequence ID" value="XP_050507874.1"/>
        <property type="gene ID" value="LOC126885357"/>
    </dbReference>
    <dbReference type="GeneID" id="126885357"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25337" checksum="20278F5383BD4490" modified="2025-10-08" version="1">MSVRYLTKAIRSISCNLGRGNFYTPLCRHNLTTFAPGINSSGTIGVGEKPKKKKTVEIPSITLIQGNHLSVTTLEEAQKLSKRRDLKLVKIVDLDTKTQRPIYKLMTGAEYHAEDIKQRLQKKEEKQGAIKGEKVLILNHKIFEQDLQTQIKKIGKWINKMYEVRVVINGDSSNMEKAEFLYSAIEKSLEKDVRIVQKRQKGSDIKFQILPPKKNKEDSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCZ6</accession>
    <name>A0ABM5KCZ6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508050.1">
        <property type="nucleotide sequence ID" value="XM_050652093.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652093.1">
        <property type="protein sequence ID" value="XP_050508050.1"/>
        <property type="gene ID" value="LOC126885512"/>
    </dbReference>
    <dbReference type="GeneID" id="126885512"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="203" mass="23146" checksum="B347FBE40771B9B7" modified="2025-10-08" version="1">MESSDDHSSDQEDGKDGFTIQNRRIRKKKKKSKGKDSTQNAETTENVTEATQEVEDSQNIGATQEVEDMDEDVPGAEGRGTTKRQRFEEDAASEDELTKANAEINRLRTLMKEFAANVDANNKRYEDVIAQQKAEIKELNTEIRRMSEKMDARFDELIALQKQLAKKSEKKNPEKTDKKPPNSPKVTGQVQRNSVFVYFQESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KET3</accession>
    <name>A0ABM5KET3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integumentary mucin C.1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508673.1">
        <property type="nucleotide sequence ID" value="XM_050652716.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652716.1">
        <property type="protein sequence ID" value="XP_050508673.1"/>
        <property type="gene ID" value="LOC126885910"/>
    </dbReference>
    <dbReference type="GeneID" id="126885910"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047160156" description="Integumentary mucin C.1-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23609" checksum="B882475D403DAE6A" modified="2025-10-08" version="1">MTSLLKISLLIFLLLLAIDQGHALECYTCIATRYEHNRCQRYATKHSLPVIKCHENATHCVSFFNDDIVARTCGTAHTCDETNSVECHLCTESYCNFHNMYRRRYIRQAENNEATNTTTTTAQSETTTTTANAQNSSTTISSTAAANAQTSSFTTSPSTGSTTTAANTDTDTASSDAPSTTSNLEQTAPTQESTSTATSLFQSVFTIFVIVSLLCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFD3</accession>
    <name>A0ABM5KFD3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508912.1">
        <property type="nucleotide sequence ID" value="XM_050652955.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652955.1">
        <property type="protein sequence ID" value="XP_050508912.1"/>
        <property type="gene ID" value="LOC126886111"/>
    </dbReference>
    <dbReference type="GeneID" id="126886111"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="118"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="236" mass="27387" checksum="AA0FF5BB634DE141" modified="2025-10-08" version="1">MAAVIGVRLLETVKEVTDFTELKTYYWSDSMVVLTWIKTKGLWNTFVGNRVKEIKKYSVVDQWPHVPGDMNIADVLSRGCSGKQLLEKQWWKGPQWLKEPENMWPKGEIMLVEPGVRKEYLAELVNYGQRREDFVKVGDVVMVGSDNAKRINWPMGKIIELYSGQDGIQRVAKVKTKNGVLVRPCLRLYRVKLPINDIQENLREDKEESTEQDKSEKVKKSRYGRTLKTPHRFTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KIE1</accession>
    <name>A0ABM5KIE1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050509986.1">
        <property type="nucleotide sequence ID" value="XM_050654029.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654029.1">
        <property type="protein sequence ID" value="XP_050509986.1"/>
        <property type="gene ID" value="LOC126886893"/>
    </dbReference>
    <dbReference type="GeneID" id="126886893"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="544"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="657" mass="76756" checksum="BB91EF69861E2B0D" modified="2025-10-08" version="1">MPKPQYRQHFRDSWLQDPHLKDWLQVIESTTGQEAKCKFCGTTLRSHYGDLKSHGMSKKHQQNKKVITTQPKIPFKPEPIGSKKKQEARLALFTAMHTSIRVVDHLGEVYNNNHEKDIEKVQLHRTKCTSIIKNVLALHFTEVLKKDFKDQPFSLIIDESTDITVHKYLGLIIIYYSKLHQKIVSTFLDLVKIHECNAEGIVSTIKKTIKRFDLRLENLMGIGTDNASVMVGVNNGVYAKLKEEVPHLILVRCLCHSLQLAVSAAAKEFLPRNLEFLIRETYDWFSRSSSRQSLYKKLYETINDGQKPLKIVQACQTRWLSIESAVSRIYTQWLELKTHFSIAKVHERCHTAELLHSMYANEMNYAYISFLYPILIEINRVNKMFESTDTDHTKLCEELINLINMLVNKVTLPTNKFNIFTQNIRDFLDKKCYLGFRFHNQILEMREKGLPREDEEMMRHRCMTFIVNLIEEIKNRLPENLTLMKKISRISVEQALNHNKEPLTDIMTQFNKSAEHIARVDDQWHQIHLLKWNETKNTKKFWNEVLHFKDAQGESRFEELATFAFTLLILPHSNADVERLFSSMNVIKNKQRNRIKLNLLTAILRVRCGLRLEGKCCNDYEIPVSVIKQIGTKESYQSETEDDGADINDSSEEEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KLM4</accession>
    <name>A0ABM5KLM4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050511099.1">
        <property type="nucleotide sequence ID" value="XM_050655142.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511104.1">
        <property type="nucleotide sequence ID" value="XM_050655147.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655142.1">
        <property type="protein sequence ID" value="XP_050511099.1"/>
        <property type="gene ID" value="LOC126887513"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655147.1">
        <property type="protein sequence ID" value="XP_050511104.1"/>
        <property type="gene ID" value="LOC126887513"/>
    </dbReference>
    <dbReference type="GeneID" id="126887513"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="406" mass="46895" checksum="5D73E14EE70E0BFA" modified="2025-10-08" version="1">MVTITNMITIEALMTFEKNLISKFECPVCFKYMNPPIRLCLSGHSYCNQCFEKLKNCALCRANKSPYRCIVLEQIHATLTFPCRYLDQGCNFSGKGDLMTTHQEYCEFSSVLCPLSMATNETIVKSLISNFECPVCFKYMHPPIGQCVSGHSFCTHCFETIENCALCKAEKSPYRCILLEQIHACLLFPCKYCDQGCIFSGKSDSLTTHEEYCEFSSVSCPLRFVRYRSCNWKGMRSEIIGHCKTNHPGKIVFQKEITRTVTTFYPVADRRKIHYQYHYILLYIHDTLFRCYWDVNAESGLMRFAVYSLDKPSFDKTFLFKIGIFLKNTGKEVVSLLGPCYPLKNDNNKFIGNMYLTTNFDMIKDLCDTSGTLRYSIEIIDRKLVLPQIIDIENKTENEIENKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KN10</accession>
    <name>A0ABM5KN10_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511558.1">
        <property type="nucleotide sequence ID" value="XM_050655601.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655601.1">
        <property type="protein sequence ID" value="XP_050511558.1"/>
        <property type="gene ID" value="LOC126887787"/>
    </dbReference>
    <dbReference type="GeneID" id="126887787"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="501" mass="56282" checksum="385D47D442A2857E" modified="2025-10-08" version="1">MSDYATHFPPQTYSSSFYINSLAEGDKTTLVIDSDDEDDNPSEMQVKNSPLLDCFISTMPKEAVLFCLALLSCVASQSPTTQNFVTQLAESVTSAMNETKECFEDKSAKIRTFSSLNEYQGNRASFDPRQPTYQGNIVNFSCNTIESLPKNSFISFGSNSIMKIDLHDKEISEIEPGAFSELFCLQELNLSHNNLTNLSEGSFEGLNSLVQLDLSFNSLQEIPDNGLTFIELKTLRVLDLSHNEIKSLNQLSFMTLDALEILRIGHNKIKTIDPRVFNYLGALKQLYLNDNSLVETSAEQWKGLTNLTDLDLSNNYLSSFDMTSNYSFAHIRNLNLSGNTLQYMNIFGIKQTFPNLLTLDLSNNNWFCQDLEVLKHGLHDSKIILPTPVDCTTESSTASTSVKTPKVEPVPNTQNNEIEKKYEQILDQHKMLMDSNEQISAAVQDLRGIVIFLFIVIILCVVVEAGMRLGICRSWYYSLMGRTSRGYFDANDSESVGLIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQ12</accession>
    <name>A0ABM5KQ12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050512278.1">
        <property type="nucleotide sequence ID" value="XM_050656321.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656321.1">
        <property type="protein sequence ID" value="XP_050512278.1"/>
        <property type="gene ID" value="LOC114334919"/>
    </dbReference>
    <dbReference type="GeneID" id="114334919"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19008">
        <property type="entry name" value="LGIC_ECD_GABAR_RDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 19" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045000700" description="Gamma-aminobutyric acid receptor subunit beta" evidence="19">
        <location>
            <begin position="24"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="40"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="253"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53209" checksum="2040B07E96894E77" modified="2025-10-08" version="1">MGHSRMVWPAVLLTLVAFGGAFAGSPGAGGSYVGDVNVSAILDSFSVSYDKRVRPNYGGPPVVVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAFRKRPSVEILSVGSEFIKNIWVPDTFFVNEKHSSFHMATTSNEFIRIHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYKWNEGPNSVGVSNEVSLPQFKVLGHRQRAMEISLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKNRFLAIQKIAEQKKLNVDGGPDDHAPKQTEVRFKVHDPKAHSKGGTLESTVNGGRGGDRGGAGPDEEAGAPIPQHIIHPNKDINKLYGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHISDVVADDLVLLESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQY7</accession>
    <name>A0ABM5KQY7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512607.1">
        <property type="nucleotide sequence ID" value="XM_050656650.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656650.1">
        <property type="protein sequence ID" value="XP_050512607.1"/>
        <property type="gene ID" value="LOC126888406"/>
    </dbReference>
    <dbReference type="GeneID" id="126888406"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="488"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="736" mass="84838" checksum="61591EB91B59E3F9" modified="2025-10-08" version="1">MENRLSVEKSNQKMSRAQRIIESALKQISQDDVSQSYNETAVNNKIEIYDDATQTSGSTELAAPDLTAESQNDMSSNSAMQEEIITSCDDDYVDNTSEDENWEPLSKKSKQRYYNRVYSSDSEDTDTSSDRFSSNINKNCNASTHNVVISSSDSDIAKKRVRKRFRNELNWKKTAAKIKRNSGSSYINSSGKTIEAKSLKPPCSINCRLKCTEKINNQERQIIFNNFYALQDLTRQRDWIVRNIKKVQPKYRYTKEGSKRSYNNNYFFECNGSKIQVCRHFFLNTLDISKRTVSTALEKCNNEGFIEGERRGKHGKHIKLDDNLLQGMFNFINAIPRIESHYLRNQTTREYIDGGKTLSDLHRDYKLECQQNKTLFGNYTAFRKTFLEKFNISFFIPKKDNCSTCEQYKNCPENEEFKLIYDAHLEVKEQAREEKRIDSLRAKNKECVTAAFDLQAVLPTPCGDASLFYYKRRLSTLNFTVYDIGNATGFCYVWNEAQARRGSNEIGSCLLYFLQNNCQNRDVIFYSDNCPGQNKNQTIPLAFLYAVEKFNVNSITHKFLPTGHTQNEGDMVHSLIEKQKKLALRSGTISVPAQWITVIQTAKKNGNPLKVQELSTEDVKDIKQMMGNKSNFSKNTLGETVKWKEISVVRVERGSPFHIFYKYNFKDEFKVLDIREKKRGRQAQLKLKPAYNDPPGISSAKKQDLLSLCTSNIINKQYHNFYESLPISNSVDTNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KT18</accession>
    <name>A0ABM5KT18_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513334.1">
        <property type="nucleotide sequence ID" value="XM_050657377.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657377.1">
        <property type="protein sequence ID" value="XP_050513334.1"/>
        <property type="gene ID" value="LOC114332466"/>
    </dbReference>
    <dbReference type="GeneID" id="114332466"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="690"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="790" mass="90496" checksum="2E8A0E07EECBFF40" modified="2025-10-08" version="1">MDIEDDIEDDNQTVFITFPPLVQKAIEEVFPSKDPLDEPDFNSIDYINSLFPTEQSLSNIDEVVLKVENKINAIDNEISTVVRGQITASEEGKQALEEAQKVIRLLFTHITDIKQQAEKSEEMVREITRDIKQLDSAKRNLTLAITTLNHLHMLVGGVDTLKSLTQRRFYGEIVLPLQAISEVMTHFENYSNIPQVKSLSDQVKSIHLELADQITHDFKEAFSGTNTKVVLPNKQLAQACLVLSILDPKVKKELLKWFVNLQLQEYSHLFEETEDTAWLDKIDKRYAWIKKHLLEFEDRLGNMFPQHWEVSERIAVQFCHNTREELAKIMVKRKNEIDVKLLLYAIQKTSAFEGLLARRFTGVTLSENSEPSKEIAENKKDLNDSKSDKDGDINSSAFHGLIGKCFIPHLEIYIESVDRNLADLIERFVLDQKQSRPTEATETQASILPSCPDLFVFYKKSMIQCNQLDKGHTMLNLTKTFQKYLHEYAEKLLLSNLPKIEPQSLGTSVQNFTKDLQKISTSGLIQNFSSLLKEGELTRFTKDEQTKICCILTTAEYCLDTTQQLEDKLKEKIEPSLVDQVDLTKEQDNFHKVISSCIQILVQDLENSCEPALTAMSKVQWQNVDTVGDQSSYITAITTHLKTNVPIIRENLSQSRKYFTQFCIKFANSFIPKFIQNIYKCKPINTEGAEQLLLDTHMLKTVLLNLPSIASQINRPAPAAYIKVVTKGMTRAEMILKVVMTPIEPSKNFVEQYKKLLPDSQLTEFHKVLDMKTVKRQDQVVLSDIFKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXA8</accession>
    <name>A0ABM5KXA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514833.1">
        <property type="nucleotide sequence ID" value="XM_050658876.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658876.1">
        <property type="protein sequence ID" value="XP_050514833.1"/>
        <property type="gene ID" value="LOC126890045"/>
    </dbReference>
    <dbReference type="GeneID" id="126890045"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="219" mass="24994" checksum="1EDBB7721D080E6E" modified="2025-10-08" version="1">MDPTRFYGKQKETHILLPDIDSDLDYSSDDSITDETYLPDMLQDSSSSDDQIVEGDQLGQQADSSDDEDLPPPLSDLTNNQIPICSNYGKKKIDLKWTNSKNEAAQTPLWGAHLQDETEVKTPVQYFYKLVDKALLDYIMEQSNLYATQTDISGNFSMDSKDLEQFLGACFYMSLISVPGTSRYWSNACRISQVADVMPLRRFEQIKKIYILLIITNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ61</accession>
    <name>A0ABM5KZ61_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515476.1">
        <property type="nucleotide sequence ID" value="XM_050659519.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659519.1">
        <property type="protein sequence ID" value="XP_050515476.1"/>
        <property type="gene ID" value="LOC114340477"/>
    </dbReference>
    <dbReference type="GeneID" id="114340477"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="349"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="664" mass="78346" checksum="E744D3C37FDD542E" modified="2025-10-08" version="1">MIHECLFNLFNNPDSESLSETYNWTSLFELQEFLHPGEQKLIQTIVEIALDYHKIVAFTKNVLIPTPNVETTTTQLPERNVPSGLYITAFCTGVYKVLDNYRKETIALEDMFLQNPQLSLTFILSKIERYRTLFQVLLSMINIIENDNVHGCLLIGRLHKYVSCGVDQIVTAADEIIKSMNTVFYRHLCNWIIYGDLIDTYEEFFIRDGKNPDENFLYPEQMAELATENLTSLSVQKRKIRRPSIVRNFFINWQMVPLFISEDLAESILFMGRIVWIIRHGPNKPGGDNNYQIEYKRDIWEGQDVEYYKKLQLLESQPFNNIEFQKTIEDCRVKLTKYLWSIMLEEGNLVKHLHLIRDYYALGRGELFQQFIRVAEDHLKDTSSDLIVQNLNFIFHETARKIYGENDKTYLKFELTSSSEVTRTNPWSRLQLNFEIDWPLHIVFHPKVMELYNKLFCYLLKLRKTQIDLHKLWADQVSEKRKIDRRVWTLRQNLMFLVNNLQYYLQVDVIEAHFSLLLKAVENANGFEDIIKVHHEFISSLLAKTFVSTPNQERTCQNKRSLYQVPAVQYDIPSRVYNIIIKLLELCDHFCLVANTWDSELADVELEELIMFQNQTDVVIESLLFILQKLHEKASGQHLLQLLSQLDFNRYFSKYRADLNSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KZ92</accession>
    <name>A0ABM5KZ92_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_050515508.1">
        <property type="nucleotide sequence ID" value="XM_050659551.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659551.1">
        <property type="protein sequence ID" value="XP_050515508.1"/>
        <property type="gene ID" value="LOC126890543"/>
    </dbReference>
    <dbReference type="GeneID" id="126890543"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="147" mass="16486" checksum="F995A4823EAB7DD2" modified="2025-10-08" version="1">MASSLGQTSVPWPNTKDDYELGKVIGVGATAVVHGALCKPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCNHENVVTYYTSFVVKEELWLVLKLLEGGSLLDIIKHKMRASNCKHGVFDEATIATVLREVLKGLEYFHSNGQIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L007</accession>
    <name>A0ABM5L007_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase cytoplasmic ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515770.1">
        <property type="nucleotide sequence ID" value="XM_050659813.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659813.1">
        <property type="protein sequence ID" value="XP_050515770.1"/>
        <property type="gene ID" value="LOC126890684"/>
    </dbReference>
    <dbReference type="GeneID" id="126890684"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057033">
        <property type="entry name" value="Ubiquitin_IARS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23567">
        <property type="entry name" value="Ubiquitin_IARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isoleucine--tRNA ligase cytoplasmic ubiquitin-like" evidence="1">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="201" mass="22447" checksum="C6C1CB9A64ED9794" modified="2025-10-08" version="1">MLISSHTLPLSRVATEYTEFIENTLKTPFKCLQSKKASDETIIEEKQKLKDFDIQILLTKNSNIQLPVVKWVNLQLVGLKSKYCKDATKGLVLLEAGSKSLSSENLKEEASRLFNVDKFSLVLKDGSPVNGQNIDKLSSQVVFVVPVEQKPELPSGSSAPFCKFLNFEEKAVKGTIILENPVGNPTKYVYQDVLKLWAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0U4</accession>
    <name>A0ABM5L0U4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8207 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516056.1">
        <property type="nucleotide sequence ID" value="XM_050660099.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660099.1">
        <property type="protein sequence ID" value="XP_050516056.1"/>
        <property type="gene ID" value="LOC126890930"/>
    </dbReference>
    <dbReference type="GeneID" id="126890930"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058520">
        <property type="entry name" value="DUF8207"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35374">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35374:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26634">
        <property type="entry name" value="DUF8207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8207" evidence="2">
        <location>
            <begin position="188"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="348" mass="40462" checksum="D92698C871EB0DF1" modified="2025-10-08" version="1">MNKDIKRQLITKRKNIQSKLRQLKQGQIIQEDLFNPITKHLKNIETKLNKNSGSENETTKYEPLRYIKNDDDDDIKEDNIEVDDEVMETEDNIKVDDEIDETEEDNEVDDDDDDDDDDDDDEIDETSDIKNSILENIEVDDIKEQIKNDKTSETGFEANQKRTLFLDQYDPLPRKYITEMQADFLNKEFDHKYGVRFDKRSEKLLIGNSEINIDGVDVLLKNKRYKGTSGLYELLFKKHPANFTDQDVNNYTKIVVATNAHRRHYLSSKQIDGSKLKKYKKIIAPITEGKGLLMEVNNNKIDYVHWDDPNELVARLRLLLSSQLAGHTGHTNEIISIIEELKEANIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L105</accession>
    <name>A0ABM5L105_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516123.1">
        <property type="nucleotide sequence ID" value="XM_050660166.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660166.1">
        <property type="protein sequence ID" value="XP_050516123.1"/>
        <property type="gene ID" value="LOC126890985"/>
    </dbReference>
    <dbReference type="GeneID" id="126890985"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="258" mass="29076" checksum="58AF1D0DA7F8671A" modified="2025-10-08" version="1">MNNNNSNGIIDTDNSPNTKKYFTALTHSPITFPSKEQGIIFSAIEGLKLQDYLLELGPIVDPKNIIFSSKISNNRVCVYLSSKSVVDKFLKEHNSIKINNRVIPVRKLVIPSQRLVLSNVSPTIPHNLLETKLKTIGLQLMSPITFLRIGAPDPAYSHILSFRRQVYISPPEDNFQIPEVLEIYHDDLTYHIYLTTDTLCYTCKQPGHLASRYASLQLQAPTSPYTKSQQQRSSLDNPSDSNNSSEAISLYQILLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1D5</accession>
    <name>A0ABM5L1D5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516252.1">
        <property type="nucleotide sequence ID" value="XM_050660295.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660295.1">
        <property type="protein sequence ID" value="XP_050516252.1"/>
        <property type="gene ID" value="LOC126891115"/>
    </dbReference>
    <dbReference type="GeneID" id="126891115"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="166" mass="18908" checksum="ADD3AF9294AE9A40" modified="2025-10-08" version="1">MNSIKKKSTKRQLELMLEFLRRNRIVLTSKTKPLEPKKLTQLWQQFALEANAIDDGPNKTGEQWRHVFNEWKTNVKRKSRKTAAQIGGTGGGPNTQTPLTDIEEQLLEIISHIHLGDPKIMDTFDFQEENDNEPGPSSSSGLQPIDTLFDVPYISSDTPIGKRLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1J1</accession>
    <name>A0ABM5L1J1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516303.1">
        <property type="nucleotide sequence ID" value="XM_050660346.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660346.1">
        <property type="protein sequence ID" value="XP_050516303.1"/>
        <property type="gene ID" value="LOC126891163"/>
    </dbReference>
    <dbReference type="GeneID" id="126891163"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="141" mass="16904" checksum="DA1CA845C494D134" modified="2025-10-08" version="1">MMKDEKKKNDDWKTKDGKMMKDEKKKNDDWKTKDGKMMKDDKKRNDDWKKKDEKTMKDAQKTRKDLKKKKDEDVKEETTSLDEDAKGEIMTKDDKYVIKDVDMNEVMTKKDEDTKTDDMTKIFTYMKKLEKEAIAQAITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1M1</accession>
    <name>A0ABM5L1M1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516333.1">
        <property type="nucleotide sequence ID" value="XM_050660376.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660376.1">
        <property type="protein sequence ID" value="XP_050516333.1"/>
        <property type="gene ID" value="LOC126891193"/>
    </dbReference>
    <dbReference type="GeneID" id="126891193"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="270" mass="30762" checksum="9A66BCC0C3323488" modified="2025-10-08" version="1">MSTNTTLDANTQAIVSPAPFNVNPPDKFNFLAPAIWPACRKRLERYMSVSGQLQKTEKQKIDILLYLMGEESEDILIQFQKIPDTYEEILNAFDKYFIPRRNIIYERFKFNSTVQKPGESIDLFITSLHTLAEHCNYGQLKEELIRDLMVVGMLDTKTSERLQLKETLTLQQCIMEARQTELQAVQNKDLLGVQRHIGRVQLNQSGASTSKVSDGQGSSGTVKKCGFCGLQFHSREQCPANKSTCKRCMKKGHWASVCKKIRSDLSKLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L245</accession>
    <name>A0ABM5L245_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516514.1">
        <property type="nucleotide sequence ID" value="XM_050660557.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660557.1">
        <property type="protein sequence ID" value="XP_050516514.1"/>
        <property type="gene ID" value="LOC126891380"/>
    </dbReference>
    <dbReference type="GeneID" id="126891380"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="257" mass="30243" checksum="C1686585558EDDE3" modified="2025-10-08" version="1">MDNDVVFGLQEYIIFDSQRPGPSSQNMVESQPKTEYKWNEDDSKILLDLYAKYKLKLGTFEIKNTKVLWIKISEQMKEFGVMVTPNNCLNRWRVLERNYKKFVYNQNKTGEQKEEGQNDENVAMEQTSEVNVTPKVLHAPAHPKASRLSSLKETRKSELEKTRTDRATYYKDRLQLERDKLEKIKIRNALIQQRNTKLENRNKLLEASNKLLEEQNQLLRKAAKIPILENEFVHSVNNHIVKYSFIITVVYSFNISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2D2</accession>
    <name>A0ABM5L2D2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flocculation protein FLO11-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516590.1">
        <property type="nucleotide sequence ID" value="XM_050660633.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660633.1">
        <property type="protein sequence ID" value="XP_050516590.1"/>
        <property type="gene ID" value="LOC126891454"/>
    </dbReference>
    <dbReference type="GeneID" id="126891454"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29136" checksum="CF7018B5EAEAF706" modified="2025-10-08" version="1">MDGRKRLSGWQYKKVAEEKKKKLTEVVNKTAKLDTFFTRSNLPVPPEPVLLESVKEFCEVELEVCSILTPSASTASASVPSALTSTPPASASAPSASTSTPLASASAPPVSTSTPSASASTPSASPSTPSASAPSASSCVDTDKIKPAISELTFVVDEIEDQLTVSEPDSSVHLKPNYDPALWIPLPNCPVFAHKSTAMTDYGSKPAGTFTGEPLPSNEAEFSLHSKSIILSQNSHKTIKELLSLGITSCMMFHKIISTTILFTIIVILSNGISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2Y4</accession>
    <name>A0ABM5L2Y4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516806.1">
        <property type="nucleotide sequence ID" value="XM_050660849.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660849.1">
        <property type="protein sequence ID" value="XP_050516806.1"/>
        <property type="gene ID" value="LOC126891625"/>
    </dbReference>
    <dbReference type="GeneID" id="126891625"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="588" mass="65770" checksum="5E4CD241992D2C97" modified="2025-10-08" version="1">MFDYCATDEHCKFFPCDEPKFCEKGLVLKKLPCKCCRECVPEDCEVDCSERLCLKPKCPRGQVPTKVDCKCCPRCARAEYLPDCNVEDCPELTCKHNEMKIDAPCRCCQIFFTFLNISYVFAANPNCTQIPEYCPTDEECTRVDCFEPETCGKGLVLKKFPCKCCRECVPEDCEVNCAAVQCLKPKCPRGQIPTTFRCRCCPRCAPAEYEPYCDEVRCRAISCRPNEVSISYVFAANPNCTQIPEYCPTDEECTRVDCFEPETCGKGLVLKKLPCRCCRECVPVNCEVNCAAVQCLKPTCPRGQIPTTFRCRCCPRCAPAEYEPFCDGVRCLAVACRPNEVSPDGRRSIRRPTKRWKDAVKEYLEKGLSGTGPTNMEAKLPISCPLACLEDCPVPEQCQPGYVLKRFPCSCCPKCVPKCEINCTKAICPQRRCARGYILKKDPSLLPCPKRPCLVACPVPPQCQPGYTLRRLPCSCCPTCEPKCKVNCTQAVCPRCMCEPGQILKKDPSKLPINCPPIACVVDCLEPESCQPGYVLRRLPCSCCPICVPKCEINCTQAVCPQRRCAPGYILKKAPCKCCPECVRLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L482</accession>
    <name>A0ABM5L482_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517252.1">
        <property type="nucleotide sequence ID" value="XM_050661295.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661295.1">
        <property type="protein sequence ID" value="XP_050517252.1"/>
        <property type="gene ID" value="LOC126891948"/>
    </dbReference>
    <dbReference type="GeneID" id="126891948"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="729" mass="81843" checksum="C83A040791A6534D" modified="2025-10-08" version="1">MESNAEFVNVAIRIKPNKSNSESQCLCIISQEPPVLLLVDRSQTFTFDNIFSEDVSQETVYNKTVKPLVHYVKKGYNSTVFAYGQTGTGKTYTMGTEPNVTDQKNVGLILRTLNQFFEYNDDDDSEVEILLSFIEIYKEKAFDLLQNDTNPLKVKGVKVEGFNKEKVYSLNEAIHFLKMGNKNRHTRGTNQNSQSSRSHAIFTIYCNTKHKDIETSAKLNLVDLAGCESVKKTGTSGSSFQEGININRGLLSIGQVMTALSNNSTFIPYRQSVITSILKDSLNKNNFVSLIACVSPIAEDSTETVQTLEFAQRVKRIKSKPEVNEVISQFRKENPLLFQLKMNTPFKRPLFMNTPKPPKQQKLSIISEPSYSSIITDQSHSPKSLSSSVASSITNTLRSSLDSVSAPQALSPIIRKYMTAMESSLMDKIGSVIQSTLKTESREQVMEKENPRTPELTWALIKNEVSKIVKSEVAQLTGNEVRATSSPLGEHLDDVRKILNYDISPLAEPGTSTTEYEFKVPELPAEQKSTSFALSPIENIMPRRSMRLSMRRRSRCSINNNNKSSVVDLEVSIESSLSFREDIKLLEQTLIDNIENSVECSTWKPPVAPRRSMRIRKSVNPLQNKLQGKTKKQLNVLNTPAGKRLLKTTQKDSPHTSHTKGVLHTINYGSSREIGKLQSVGPKTAQHISLFRDIKGKLSTLSDLKQIPGWGPKKFDRFVEQNLLKEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4A1</accession>
    <name>A0ABM5L4A1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517266.1">
        <property type="nucleotide sequence ID" value="XM_050661309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517267.1">
        <property type="nucleotide sequence ID" value="XM_050661310.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661309.1">
        <property type="protein sequence ID" value="XP_050517266.1"/>
        <property type="gene ID" value="LOC126891955"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661310.1">
        <property type="protein sequence ID" value="XP_050517267.1"/>
        <property type="gene ID" value="LOC126891955"/>
    </dbReference>
    <dbReference type="GeneID" id="126891955"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="384" mass="44486" checksum="9B2711B8F5552D4B" modified="2025-10-08" version="1">MSEHCCEVCNVSFSSKTNLSRHLKTKHAKNKVKYDCGICEYSSPRKDNLFLHQTNKHRPNFEEVDSSEIKPKSVVACAMCDHKTETKTVMLEHYKLRHGITLAEKESLMFASEDKFLEWKLEVENSDKNNFVRQRAKKSAAGGKSISTFHCFRDGYFKKRGSNIRREKMSGSNKINGYCPAKMVAFTLPTGEVKVDFYKTHVGHQNDIKRMRLSKGERDEVAKNIAAKIPLEIILDNLKTTLSNDEVKVKRRDLITLQDMRNIARDYKLKAERKVKPKKTARRKHHKISLQLDVCDDDRDHNDSFTHEEPVEWVPQDIILSDMQNQEMIPDIGLKRKKDLAMNQFLSVLHEANSEVDVDFIIKMIQQTQATMRAQNSVQHITMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5H0</accession>
    <name>A0ABM5L5H0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517687.1">
        <property type="nucleotide sequence ID" value="XM_050661730.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661730.1">
        <property type="protein sequence ID" value="XP_050517687.1"/>
        <property type="gene ID" value="LOC126892233"/>
    </dbReference>
    <dbReference type="GeneID" id="126892233"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="378" mass="43729" checksum="FD150D1700E3CC24" modified="2025-10-08" version="1">MENFIEEVFFGDDEIIPAVINEVIDLAQPPQNIIPEERQQVTRNEQYYEYTIPRYTNDAFREHFRMSRVTFERLFNCIRAVHHIEDRLVPLEKKILFTVWVIGKPESFLAAGDRFGLAKSSAHKIFYQIVDELGQITNQYIRWPNMQKIQQTANVFELRSRGIPGVVGAIDGCHIPIKQPVRNANDFYNRKGFHSIILQGVCDENGVFIDVNIGRPRRMHDARVFRLSEIYEYLTRENSILPANLHLIADSAYPLLLNLMKPFQDNGHLPEEHVVYNTKLSSIRSTIERAFGLLKCKFRRLKYLDVNHSQIASRIVLAACVLHNFILLQGNAALDDYDIVNAAPNENMIEGVHENDLLVNDASNKRREIVQICNRENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5Z4</accession>
    <name>A0ABM5L5Z4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517858.1">
        <property type="nucleotide sequence ID" value="XM_050661901.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661901.1">
        <property type="protein sequence ID" value="XP_050517858.1"/>
        <property type="gene ID" value="LOC126892383"/>
    </dbReference>
    <dbReference type="GeneID" id="126892383"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381:SF3">
        <property type="entry name" value="SGC REGION PROTEIN SGCQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="ZGC:162297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="270" mass="29696" checksum="201C2F8995670D73" modified="2025-10-08" version="1">MNKFRQLFGKSLSVIGMVHVKALPGTPLFSGSINSIVKKACEETELYLKHDVDGILVENMHDVPYIQSQHFGPEVTATMSRICAELRRIIPKTKAFGVQVLACGNKEALAIAKACSMDFIRAEGFVFSHVADEGFTDANAGNILRYRKSIEADNVLVFTDIKKKHSSHAITNDISLVETAKAADFFLSNGVILTGTATGHAADIKELQQLKSSISLPVLIGSGVTYENLENYKSADALIVGSYFKKDGKWDQEIDENRLSKFMEKMKSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6B1</accession>
    <name>A0ABM5L6B1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="RefSeq" id="XP_050517977.1">
        <property type="nucleotide sequence ID" value="XM_050662020.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662020.1">
        <property type="protein sequence ID" value="XP_050517977.1"/>
        <property type="gene ID" value="LOC114330264"/>
    </dbReference>
    <dbReference type="GeneID" id="114330264"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="439"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="438"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="564"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="609"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="697"/>
            <end position="700"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="815" mass="89904" checksum="AC53D028B6C2193D" modified="2025-10-08" version="1">MTDSSSKSKFIERGAYKGKGLAVFTSGGDSQGMNAAVRAVVRMGIYLGCKVYFIKEGYQGMVDGGDNIVEANWSSVSCIIHKGGTIIGSARCMDFKERAGRLKAAKNLVDRGINHLVVIGGDGSLTGADLFRQEWSSLLDELLSGGQITPELRDKNKNLQIVGLVGSIDNDFCGTDMTIGTDSALHRIIEAIDAIVSTAYSHQRTFIMEVMGRHCGYLAIVAALTTEADYVFIPESPPPGDWKKRLCDKLEQERAAGQRLNIIIVAEGAIDRNGVAITAEQVKKVVVDNLHQDTRITVLGHVQRGGNPSAFDRVLGSRMGAEAVMALMESTEETEACVISLDGNQAVRIPLMEGVKQTKAVAKAMDEKQWDKAVELRGKSFQRNLETYKLLTRLKPPKEFFEDGAKIKSANREPVDFCHQTNNRLHKQDTLWGSEGYVMAVIHVGAPACGMNAAVRSFVRNCIYRGDTVIGIHDGWEGLLAGNVKKMAWSDVTGWVGQGGAYLGTKRSLPTNKLDQVAKRLVEYGIQALLIIGGFEAYQSGLMFTENRDKYEAFRIPIMVIPSTISNNVPGTEFSLGCDTALNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIHEEKFTIKELQEDVYHMAAKMSEGVQRGLILRNEKASDNYNTEFIYRLYSEEGKGLFSARMNILGHMQQGGSPTPFDRNLGTKMAAKAVDWFVCQLKNNMVDGKPNCTDPNTACLLGVLKRQYKCTPLSVLKEETNFDKRIPKEQWWLKLRPLLRILAKHDSAYQEEGMYLTVEEHNQADNLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7S0</accession>
    <name>A0ABM5L7S0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518487.1">
        <property type="nucleotide sequence ID" value="XM_050662530.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662530.1">
        <property type="protein sequence ID" value="XP_050518487.1"/>
        <property type="gene ID" value="LOC126892797"/>
    </dbReference>
    <dbReference type="GeneID" id="126892797"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="129" mass="14848" checksum="CBC0B316E01140EA" modified="2025-10-08" version="1">MKDRVYKVEIKLDSDHEVEEATCTCPRGQLICHHMAALLIYAYHNVSVTDVACSWAIKKQPTCDRVETIDDKYGAQAPHQSIRGPITREPFDKARDTFGSYENVVACRFLLRKEPKIPEDNRCRKCCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L961</accession>
    <name>A0ABM5L961_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518969.1">
        <property type="nucleotide sequence ID" value="XM_050663012.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663012.1">
        <property type="protein sequence ID" value="XP_050518969.1"/>
        <property type="gene ID" value="LOC126893070"/>
    </dbReference>
    <dbReference type="GeneID" id="126893070"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="123323" checksum="EE8A5A4194FBDE45" modified="2025-10-08" version="1">MDIVKQCKNLLLFIKRIRKIVFDKFTAKDKEIWVKRLTKQIKTCNKERDSGFALNRIVSLEVNINRYEIGNGSSYIKLPESIQKKRACINVKNSDQACFYWAIVSALYPAKAHKELPSSYPWYSTVLKTEDLEAPMPLHQISKFEKLNNISVNVFALELIENNEKSFFTVYPARLTKTVVAKHVNLLLIQNHYFPKLNDYEAPPVDNDNSEIKYHYCHITDMSKLVAGQLNKRKAKLFLCNRCLNYFSTEGKLSEHEKMCADMNNCKMSFPKYDAVSFKNYTYKQTTPFVIYADFECMLEKVTDLQTSCCTKKYQKHIPYSAGYYVKCSYDEKLSFFKSYRGIDCMEWFANELPNLAQSIHSKIKKIIPMQENPSTSKATRCHICEKCFSPTDIIVKDHDHFTGEFRNFAHQACNLNFKKLFVVPVIFHNMSGYDSHFIISELSKKGDISLLPVNKEKYISFTLNDAVTNIKFRFIDSLRFLGASLDELVSTLNKNDFKICKREFSRLSDDEFKLITKKGVFCYDFIDSWEKLNITDLPPIEAFYNKLNDTNLTDEKYAHAKIVWDTFNIENLGQYSDLYLKTDIVLLADVFETFRKKCFITYGLDPAWYYTMPGYSWDCMLKYVGCNLELLRDVDMILFMEKAIRGGISVCSGRMSEANNKYMSNYDPAQPSKYLMYFDVNNLYGWAMGEPLPYGGFEWMDAKDIDVMSVPDDSPVGYMLQVDLDYPRQLHDLHSDFPFAAEHRKALGSNHTKLMTTLYNKKEYIQSAWLRPYIELNTRLRAAATNDFGRNLYKLANNSVFGKTMENIRKHRIVKLVRSWNGRYGAKNLISSARFHSRKIFNENLVAIELIKSDLVFNKPLYIGMTVLDISKLCMYQFHYDYMLPKLGADKCNLMYMDTDSFIYELYCHDAYEEVIKQDLSKFDTSDYAVDNIYNIPRVNKKVLGVMKDENKGEIMTKFVGLRSKMYTFKVQSGRITKKAKGTKYNIVKNVIKFDDYVNCLNDFKEQTATQHSIRSYSHNVYSIEQTKIALSPYDDKRYLIPNSFRTLPLGHYSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9Q5</accession>
    <name>A0ABM5L9Q5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519165.1">
        <property type="nucleotide sequence ID" value="XM_050663208.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663208.1">
        <property type="protein sequence ID" value="XP_050519165.1"/>
        <property type="gene ID" value="LOC126893230"/>
    </dbReference>
    <dbReference type="GeneID" id="126893230"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="298" mass="34836" checksum="BE72522E6C242D47" modified="2025-10-08" version="1">MSLMVIWLNELIIFDRKILKSYVNINFQQEYLIIFLISLILSTISLSTTVFIFAVDILCFFPSSFKSVSANICYCAPIMATNMFFLKICAMLLIMKQRFKWINHGIENLKHMSDEKSAFYYAIHTFDKNFQVMCLQEQQIHALEELRIKHYKIHCLTEEINSMFAFPILFSFIQLVLGFQNYSLYFIRVPSTMFAQKTTKLYSFFGKGIIAIYTGQLVAISYICSWLNYEAHRTGSILERFKHISNEIDEYIRFFLHQLLHTEVNITACNLFTINASLIFSVASAFTSYLVLCVQLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LA82</accession>
    <name>A0ABM5LA82_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519349.1">
        <property type="nucleotide sequence ID" value="XM_050663392.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663392.1">
        <property type="protein sequence ID" value="XP_050519349.1"/>
        <property type="gene ID" value="LOC114330898"/>
    </dbReference>
    <dbReference type="GeneID" id="114330898"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="3"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="525"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1569" mass="176160" checksum="0681FADEF84D93D7" modified="2025-10-08" version="1">MALVVQLAEGKISGGVKTDLNGEKFHSFLCIPYGKAPVGELRFKAPLSVEPWEGIKEVITEDKIAFQKNSLLNTYFGQEDCLSLHVFTRKLPSEETKLKPVMVFIHGGGFLAGFHETKTYGPEYLMTEDIVLVTITYRLGLLGFLSLKDESLDVPGNAGLKDQVLALKWIQRNIKNFNGDTNNITVFGESAGAASVEYLLLSPTAKGLFHKAIIQSGSTLNPWALRNFPLFEFAKFHGKSNMTEEELLKRLRDIPVEEVYDLQHNFVKSKKLFSDLGLISPVIEKPNPTAFLTEKPIHIIQSGKYNDVPVIIGYNDSEGLFADIIATLKMVDAKVIADTPLEQMLPYDTNFTDTQQVERLVNKLRNFYCPETDPIGRINLITDAFFAAGIKISAKSQAKVSKNPVYFYRFTLSGGLNLMKKMINGRCPGACHADELGYLFKNALATDLKDEDKTSITKLVTLWTNFAKFSNPTPSGNNLNIEWKPVQSGQLNFLDIGKQLKMDVNPEPDRMSLWNDIYQCNKNMAPVVQLVEGKISGGTKTDLNGEKFHSFLCIPYGKAPIGELRFKAPLPVEPWQGIKEVITEDKIAFQKNSLLDTYFGQEDCLSLHVFTRKLPSEETKLKPVMVFIHGGGFLQGSHETKAYGPEHIMTEDIVLVNIAYRLGLLGFLSLKDESLDVPGNAGLKDQVLALKWVQRNIRNFNGDPNNVTIFGESAGAASVEFLLLSHSAKGLFHKAIMQSGSTLNPWSLRNFPVTEFAKFHGKSNMSEKELLKSLRNISVKEVYDQQNNFIKSKQLFADLCLVAPVIEKPNPTEFITEKPIDIIQSGNYHDVPVITGYNDGEGLFADIMVILKIADGKVIADTPIEHLLPYETNFSDTQQVKRLVDKLGNFYRPKDDPIGRINLLTDAFFAAGIKISAKNQAKVSKNPVYFYRFTLDGGLNLMKKMVHDRRPGASHADELGYLFKSPLATDLKDEDKTSIRKLVTLWTNFAKFSNPTPSGNNLNVEWKPIQNGQFNFLDIGRQLKMDVNPEPERMSIWDDIYQCIKNMAPVVQLVEGKISGGTRTDLNGEKFHSFLCIPYGKAPVGELRFKAPLPVEPWEGIKEVITEDKIAFQKNFLLNTYFGKEDCLSLHVFTRKLPSEETKLKPVMVFIHGGGFVAGSHETKILGPEYLMTQDIVLVTIAYRVGLLGFLSLKDESLDVPGNAGLKDQVLALKWVQRNIRKFNGDPNNVTIFGESAGATSVEYLLLSPSAKGLFHKAIMQSGSTLNPWCLTNFPVTEFAKFHGKSTMSEKELLKSLRDIPVKEVYDQQNSFLKSKKLFADFCLISPVIEKPNPTEFIIEKPIDIIQSGKYNDVPVIIGYNDGEGLFADIMVALQLVDAKVIADTPIEQMLPYETNFTDTQKVNRLVEKLRNFYRPKTDPIGRINLLTDAYFAAGIKISAKVQAKVSKNPVYFYRFTLDGGLNLMKKMVHDKRPGACHADELGYLFKNAFATDLKDEDKTSIKQLVTMWTNFAKFSNPTPPGNNLNIEWEPIQNDQFNFLDIGKQLKMDVNPEPDRMSIWDDIYHYIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F0K5</accession>
    <name>A0A6P7F0K5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC114325281</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114325281</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129099.1">
        <property type="nucleotide sequence ID" value="XM_028273298.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129100.1">
        <property type="nucleotide sequence ID" value="XM_028273299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F0K5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273298.1">
        <property type="protein sequence ID" value="XP_028129099.1"/>
        <property type="gene ID" value="LOC114325281"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273299.2">
        <property type="protein sequence ID" value="XP_028129100.1"/>
        <property type="gene ID" value="LOC114325281"/>
    </dbReference>
    <dbReference type="GeneID" id="114325281"/>
    <dbReference type="KEGG" id="dvv:114325281"/>
    <dbReference type="OrthoDB" id="6677380at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="562"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="650"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028129099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028129100.1"/>
        </source>
    </evidence>
    <sequence length="694" mass="80470" checksum="F7B7142A57A1B52E" modified="2020-12-02" version="1">MENSEENNTTKTKPEFLLTSEVAKKLRCSFCGLYLSYPPINMTTQDERENKVKYKCGRCSIKTRFNFRNSLYEDLATYMKFPCIYKGCSETVDLESVRDHEKDCEHRTIPCLASDCKETVLEANFASHFKEKHKKLYHSEKIFIESFRGTGFAVLEKDNVCYILFYELSVDTYRFALCGIKNNDKQFEVVLRAKNSKNSVHLTENNIVLHNDRVYCYRCLKGDCKYEYHLYSSYRRGMLKYVYAKIEKPILKRTFGSDYSCTVNVVEVKAENENDIEDLLLGKDVVIDEVTEEDEIEEEKPSEPTKADALKNFLKCPGCEIPFTEPIFQCLKGHALCKDCKDKADGDGSKCFFCDAHIDNTRNYIVEETIANLKLNKDSPSTFQDAEVVCPTSKCHQKVKLSAISTHFKESHIENFHFNKFYLKNVYGYYNVEVLVKNEKTYLLFFDFDDQQFGVSVCSIEDTDETFDLMLLSDNKKFFILAEDQKIIKFNDKEHCFKCSRGTCKISDHIYKVKRKEIFRRLTTKLNRDAVKYRTNTLNYQIVLKEYKEDKTDKLIKQLFECPICKDYMIPPIHQCKAGHTLCNVCKAKVEKCPSCEGSIEDTRNFILEDIAEGVEIPCSFESKSCKFRSGVKRMATHELECPLNSKRRCVEEPKPSEEKDKPNEESTANATEVTNNSQEETTTSEDVVELSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F191</accession>
    <name>A0A6P7F191_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114324914</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128637.1">
        <property type="nucleotide sequence ID" value="XM_028272836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F191"/>
    <dbReference type="FunCoup" id="A0A6P7F191">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272836.2">
        <property type="protein sequence ID" value="XP_028128637.1"/>
        <property type="gene ID" value="LOC114324914"/>
    </dbReference>
    <dbReference type="GeneID" id="114324914"/>
    <dbReference type="KEGG" id="dvv:114324914"/>
    <dbReference type="CTD" id="39950"/>
    <dbReference type="InParanoid" id="A0A6P7F191"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028128637.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9500" checksum="1D377107F35CA21B" modified="2020-12-02" version="1">MGHGFGQLYKLRGIITYKISHFEQKAFTGMISHGVPNTIRRILDQVLYVVPPLGIGYIVYDQVEKEHHRLMLKNPADYENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F406</accession>
    <name>A0A6P7F406_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114324563</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128225.1">
        <property type="nucleotide sequence ID" value="XM_028272424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F406"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272424.1">
        <property type="protein sequence ID" value="XP_028128225.1"/>
        <property type="gene ID" value="LOC114324563"/>
    </dbReference>
    <dbReference type="GeneID" id="114324563"/>
    <dbReference type="KEGG" id="dvv:114324563"/>
    <dbReference type="InParanoid" id="A0A6P7F406"/>
    <dbReference type="OrthoDB" id="6744268at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028128225.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40963" checksum="934441BB5DF1A1BA" modified="2020-12-02" version="1">MNLAANIALNLTDELYKSKYFSLALDSSTDITAISQLLLFVKYVSKDCVLKEDFLGMIPMTGQTRGIEYLNTTVNFFNEHSIDLIKVFSVCTDNCPSMLGQNIGFVQLLKKHLGNDNLLSFHCIIHQKSLAAKFGENFSCVMKTLVKIVNVIRSNELNYKEFQEFLKELSQYGDIIYHTVVRWLNKGKVLERFFSIRHEITLFLATKSKEFLDIYNFSWRLKVAFLTDTMSTMNETLTKWQGDYNNIVTKMLSSAFSLEQKQNIMYIEEFSNEDYSSFPSVKALFDEQSDENQKIYDLLKLLADLKDEMSVRFSDFRKFQEPFRLVENPWAITTANVAHLSIFGYEARDLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F766</accession>
    <name>A0A6P7F766_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Transient receptor potential channel pyrexia isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114327274</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131629.1">
        <property type="nucleotide sequence ID" value="XM_028275828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F766"/>
    <dbReference type="FunCoup" id="A0A6P7F766">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275828.2">
        <property type="protein sequence ID" value="XP_028131629.1"/>
        <property type="gene ID" value="LOC114327274"/>
    </dbReference>
    <dbReference type="GeneID" id="114327274"/>
    <dbReference type="KEGG" id="dvv:114327274"/>
    <dbReference type="InParanoid" id="A0A6P7F766"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="678"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="638"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="961"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028131629.1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113385" checksum="E27D904473A3E339" modified="2020-12-02" version="1">MWTFRKKTKSLEATRQKRKESYEMVSASENHTFYGMDNYGLQDSSCNSKRLGRSVSVNVDATNLHLYRTPTSNTILRWKKVIDDSENIFEEELPSDDFEYMECGPSPPADHTPHIYESFEEFSTSADLTVQICHDTIKTNLLEHMKVSSGRHQLLDDIESKKIQKDNLQDHFKGASKVEINTAFLWAAFMKRHDLLDGFLNLGADLHYFEPSQGLSAIHLTSFSGCVQGTKFLIAKSCDVNSLYKCYSPLHCAAFGDSPETALILLNNDANVQTLTNSPHSSHESVLHCAVRANAIACVKLFTQEGADVAQSEISGFSPVHLAADLGHPQCLKILLEPKKFKVNTKTKDKEQTPLHLAAESGYVDCIEILLDNGADANIRNHRQQSPLHLAARAQAYDCVEMLLRKGNSNPNMGDCDKRTPLHCAVGKAARSYDIIEILVNYGADINTKDQYGYAPLHIAALNELSQCVEVLVYHGADVTAKSKFGMTALGIITRKTPASLAMITQKLDSAITLHHHPESSNREVELRLDFRGILQYCHPREISFLNTFVDEGQKEILLHPLCSAFLYLKWEKIRKYYIARMLFCFIFVLSLSLYVLTALAHNCYNHGKNMNDTQPQNVIELCEKKSMMGHMLRNNPFVIEMQWFVLVGITGCEILRKLYGLAGYPSVRQYLSHPENIIEWTVIASVFVISFIYTGRTYTWQNHVGAFAVLFGWTNLMLMVGQLPVFGSYVAMYTRVQGEFAKLLLAYSCLLIGFTISFCVMFPDSSTFANPFIGLITVMVMMTGELSLDLLVDDDPEDPPFLLEVSAQVTYILFLLFVTVILMNLLVGIAVHDIQGLQKTAGLSKLVRQTKLISYMELALFNGYLPQYLLNLLHWTALVSPKAYRVVLNVKPLNPREKRLPKDILKAAHDIAKQRKNYGHTISSRASEMAYSKKVVNNNLDQNSEIMDCNTALPLLHSKIEKNSEQVEHLSKEIRELKSVIESNQRLVEQLLNTILQNRKNSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8G0</accession>
    <name>A0A6P7F8G0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114327397</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131806.1">
        <property type="nucleotide sequence ID" value="XM_028276005.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050505863.1">
        <property type="nucleotide sequence ID" value="XM_050649906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8G0"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649906.1">
        <property type="protein sequence ID" value="XP_050505863.1"/>
        <property type="gene ID" value="LOC114327397"/>
    </dbReference>
    <dbReference type="GeneID" id="114327397"/>
    <dbReference type="KEGG" id="dvv:114327397"/>
    <dbReference type="CTD" id="39861"/>
    <dbReference type="InParanoid" id="A0A6P7F8G0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000010">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha-13 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF367">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(F) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="166"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028131806.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43305" checksum="1F20BE5A9016644A" modified="2020-12-02" version="1">MGCGSKVKEDRDHELYTKKFLQTVKLLLLGTGESGKTTIIKQMKILHINGYSNDERREKIPFIKQNIHESIFDIVSNMSRINPPVEAQSEESKASIEYILNLGPGCPSEFTEEYIHHVKTAWADAGVQKTFNRSNEYQLIDSAEHFLNQVDVVCKPDYIPTNQDILFCRIMTVSISKIEFDMPVPKQYGGGKAEFWMFDVGGQRGERKKWIKVFAGIQGILFLIAASDFDLMLREDTSVNRLEESFRLFQDIYSSEYVEKVAMIVFLNKQDLLQRKIEQGRKLAKYFPEYSHFNVSDTSEYEKAKLFMKQKLLGIAQTPVNVEKSVKRGKNITERIAPRDTYIHYTIATDTNNIKRVFDSVHESILRTTVQEVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FE74</accession>
    <name>A0A6P7FE74_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114329193</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_028134026.1">
        <property type="nucleotide sequence ID" value="XM_028278225.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497546.1">
        <property type="nucleotide sequence ID" value="XM_050641589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FE74"/>
    <dbReference type="FunCoup" id="A0A6P7FE74">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641589.1">
        <property type="protein sequence ID" value="XP_050497546.1"/>
        <property type="gene ID" value="LOC114329193"/>
    </dbReference>
    <dbReference type="GeneID" id="114329193"/>
    <dbReference type="KEGG" id="dvv:114329193"/>
    <dbReference type="CTD" id="44573"/>
    <dbReference type="InParanoid" id="A0A6P7FE74"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14089">
        <property type="entry name" value="STKc_MAPKAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000094">
        <property type="entry name" value="MAP kinase-activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1170.10:FF:000001">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028134026.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40147" checksum="2C4F16BE7B514F49" modified="2020-12-02" version="1">MSNANRMSTGALPKSNPITEDYEISRTVLGLGINGKVVECYSKTTKEKYALKILPDSAKGWREADLHCKATGCRHVVEIIDVYENTYKRHAAVLMVMECMEGGELFQRIQDKAEGAFTEREAAQIMHDICIAVKYLHDRDIAHRDLKPENLLYSKPGPLGVLKLTDFGFAKETSSLVTLQTPCYTPYYVAPEVLGSQKYDKSCDIWALGVIMYILLCGYPPFYSDHGLSMSPGMKSRIRAGQFTFPDAEWKQISPDAKHLITGMLTVDPTKRFTIDQVMNNRWIAQYAAVPQTPLHTNRVLKETVELWPEVQEEMTRSLATMRVDYDQVQIKTLENSNNPLLNKRRKKNAITTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FM47</accession>
    <name>A0A6P7FM47_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Paxillin isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114331723</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Myofibril</location>
            <location evidence="11">Sarcomere</location>
            <location evidence="11">M line</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137146.1">
        <property type="nucleotide sequence ID" value="XM_028281345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FM47"/>
    <dbReference type="FunCoup" id="A0A6P7FM47">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653372.1">
        <property type="protein sequence ID" value="XP_050509329.1"/>
        <property type="gene ID" value="LOC126886435"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FM47"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09336">
        <property type="entry name" value="LIM1_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09337">
        <property type="entry name" value="LIM2_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09411">
        <property type="entry name" value="LIM4_Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Paxillin isoform 1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Paxillin_Lim_dom4"/>
    </dbReference>
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        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
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        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="372"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="430"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="490"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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            <dbReference type="ARBA" id="ARBA00023038"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
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            <dbReference type="EnsemblMetazoa" id="XP_050509329.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028137146.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="60843" checksum="4C79B4F14448724D" modified="2020-12-02" version="1">MSAKLRMRTPSPKTVTFDPSPPTTLERPRKLIFRSRAEWERYLDALLADLQNTVSGSSGIGSNYSGYGQRNVRYSPDSDGHYSKTDSYSVKSGSYGKVPPNSGNRSPSYGLNATAGHSASSTMEKRPFNNNLDELDSLLQDLSNSRQHASENMNGSHYNGAIADYGGRSSANYSRPSSAQSTLNRPSVDSLLDELNSGDVIYTGPKKVVITVKETKTETGYPGETELISSHVTHTAASSATRELDDLMASLSNIKVNQGPQHHTVSDSQYARPIKATQTQSAPPPPKQNLDSMLGNLQADMSRQGVNTSQKGCCSACDKPIVGQVITALGKTWHPEHFTCAHCSQELGTRNFFEREGKPYCEPDYHNLFSPRCAYCNGPILDKCVTALEKTWHMDHFFCAQCGKQFGEEGFHEREGKPYCRDDYFDMFAPKCGGCNRAIMENYISALNAQWHPDCFVCRDCRQPFIGGSFFDHEGQPYCETHYHLKRGSLCAGCHKPISGRCVTAMFRKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCHTCFEKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FMI5</accession>
    <name>A0A6P7FMI5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114331825</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_028281495.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658374.1">
        <property type="protein sequence ID" value="XP_050514331.1"/>
        <property type="gene ID" value="LOC126889786"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FMI5"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028137296.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16829" checksum="A0FAF9C928901D43" modified="2020-12-02" version="1">MAFNFPAFSYIIALIVDAFLIFFSLFHVIAFDELKTDYKNPIDQCNSLNPLVLPEYLLHLLFNILFAASGEWFSLCLNIPLIAYHINRYRTRPVMSGYGIYDPTSIMNADVLTRCQREGWVKLAFYLLSFFYYLYGMIYVLISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FP68</accession>
    <name>A0A6P7FP68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAR DNA-binding protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114332391</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028137981.1">
        <property type="nucleotide sequence ID" value="XM_028282180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FP68"/>
    <dbReference type="FunCoup" id="A0A6P7FP68">
        <property type="interactions" value="2486"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282180.2">
        <property type="protein sequence ID" value="XP_028137981.1"/>
        <property type="gene ID" value="LOC114332391"/>
    </dbReference>
    <dbReference type="GeneID" id="114332391"/>
    <dbReference type="KEGG" id="dvv:114332391"/>
    <dbReference type="InParanoid" id="A0A6P7FP68"/>
    <dbReference type="OrthoDB" id="2020831at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19609">
        <property type="entry name" value="NTD_TDP-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12321">
        <property type="entry name" value="RRM1_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12322">
        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000098">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000107">
        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="112"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="391"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028137981.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="49953" checksum="3A3AEA3EBBF8AD29" modified="2020-12-02" version="1">MSIEYLQVAEDEGEEPIELPTEDDGTLLLSTLSAQFPGSSGLKYKNPETKTFRGVRLSEGRLHPPPDDGWGSHIFYCVFPKVTILENKRKSDDNLENSTAKTKRMETKLRCTDLIVLGLPWKTTEQNLREYFETFGEVLMAQVKKDPKTGQSKGFGFIRFASYESQMRVLAQRHMIDGRWCDVKVPNSKEGLIQQVPCKVFIGRCTEDLTADDLRDYFGKFGEVTDVFIPKPFRAFSFVTFLDPEVAQSLCGEDHIIKGVSVHVSNAAPKSDTRGGNYRGDRNNGLQNRGGGVGPGGPDGPGMYNQRYNGAGPNQGNWGNQGGPRGNIDMPNLQALGITGQGQQGNNQGNCNPLGMGLNALGALPMNPAIVAAALNQAGWGLIGNLQNQPEPNFNQGFNNGPNAGNQNNQNGGGRVGNNPGFLNWMNPGGGNQNNPDGSQWNRQPQQNQEKGFLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQ35</accession>
    <name>A0A6P7FQ35_DIAVI</name>
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        <submittedName>
            <fullName evidence="4">UPF0329 protein ECU05_1680/ECU11_0050-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114331489</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_028281076.1"/>
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            <begin position="1"/>
            <end position="116"/>
        </location>
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        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
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            <begin position="41"/>
            <end position="57"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028136877.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="14078" checksum="77529925858346C8" modified="2020-12-02" version="1">MKISYPELDVFDVPPRANTATGQGRRDDEEEDDVSDIDQDDERRKEEKRQLEDEKIRLQKKNHNWKKKVGKMMKDEKKKNEDWKKKDEKTMKDAQKKKDLKKKKDEDVREETTRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUP1</accession>
    <name>A0A6P7FUP1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi to ER traffic protein 4 homolog</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">LOC114332914</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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            <tissue evidence="8">Whole insect</tissue>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">Cytosol</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the GET4 family.</text>
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    <dbReference type="OrthoDB" id="10252405at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028138497.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37629" checksum="4BE9BE9D005321BA" modified="2020-12-02" version="1">MATQGVRGVSRVLQKLEKSVIDGKFYEAHQMYRTLYFRYMGQKKYKELKDMLYNGAVLFLEREQQLSGSDLGILLIEVLEQSEDSNYELWAPKLTNIFRQINISTPERDTFLAHAVRWSSKGSSHGHPQLHRSVALVYWAEKNYSQARHHFIYSQDGKSCAKLLIEFHRSRGFKEEADLFIAQTVFQYLCLKNKSTANQTFTSYTEHHPRIQGSGPPYLFPLLNFIWFLLQAIETKSTIHTFLLLIGKYEPSLKRDPGYIQYLDKIGQIFFGIKPPQQQTQNNSFFGHLFENLISGLDEDSDEEAPQASTSGTSTNKTMVENDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYD7</accession>
    <name>A0A6P7FYD7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114334035</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139837.1">
        <property type="nucleotide sequence ID" value="XM_028284036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYD7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050658880.1">
        <property type="protein sequence ID" value="XP_050514837.1"/>
        <property type="gene ID" value="LOC126890050"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FYD7"/>
    <dbReference type="OrthoDB" id="8187082at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027649717" evidence="2">
        <location>
            <begin position="35"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="54"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="208"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="366"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028139837.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="59532" checksum="0005BD8D322A85AE" modified="2020-12-02" version="1">MCLYIFRRFKQIYKNKMCRWWVCSLLFLFPLVLGDAPSVFDPAGVVPLEKCEKCGNKNYYFSYKFKANYFHADQICRDMNMTLVTIPSKEVNDFLYTTVLSANGEINFWTSGTNLVDKVSWMWMSNAQPITYSNWNVGQPTASAYRCLLGQMIRGKDFLWMNVDCNGLYNFVCESIEPAASSKTGGSENWAKLFADPSVSPNFPLFNYNKKSYYVNTQAMSFLDANRFCRMINMELVSIESDAENTWVYRWLRNINLGTTYWSGGTNLINGFDWIWFSSGRKVVFTKWMKGQPATINQRCIQLIVNKGLGMEWVSLGCEVLLPFVCQSPTDKITRRPATVGPNGNSGSCEVKEVKEVKEVISPVVNTYHTYKVLTTPVHYKQAVAACEAAGMSLVSIQSKEKSDSVTSKLQKISQTGAFWTSGHKIDNKWFWLKGEPITFTNWNDGEPNNKRGNENCLTVFKSGTGSLWNDDPCDFKFIPVCEIAVTVQNEESREKIIASQNECCKAPVVNVFVDRDQDNYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G508</accession>
    <name>A0A6P7G508_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114335989</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142092.1">
        <property type="nucleotide sequence ID" value="XM_028286291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G508"/>
    <dbReference type="FunCoup" id="A0A6P7G508">
        <property type="interactions" value="1626"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653605.1">
        <property type="protein sequence ID" value="XP_050509562.1"/>
        <property type="gene ID" value="LOC126886615"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G508"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028142092.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37497" checksum="2F4967250DCEE7F3" modified="2020-12-02" version="1">MKSQTEYKLKSAPEDAISAVKFGPNTNQFLLVSSWDGYVRLYDVIANNMRHKYAHDDAAVLDCCFTDAVHSYSGGLDAVLKSFDFNSTKESSVGNHAAPIKCVEYCSEINAIITGSWDHHVKLWDPRQHACSGSYNQGERVYTMSVCGEKLVVGTAGRKILVWDIRNMSYTLQKRESNLKYQTRAIRCFPNKQGYVLSSIEGRVAVEYLDTNPEVQKKKYAFKCHRIKEDGLEKIYPVNAISFHPIHNTFATGGSDGYVNIWDGFNKKRLCQFHQYHTSVTSLSFSHNGSVLAIACSYFLEEDPLPEPLPEDVIYIRAVTDQETKPKYVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G558</accession>
    <name>A0A6P7G558_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114336026</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114336026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142132.1">
        <property type="nucleotide sequence ID" value="XM_028286331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G558"/>
    <dbReference type="EnsemblMetazoa" id="XM_050652686.1">
        <property type="protein sequence ID" value="XP_050508643.1"/>
        <property type="gene ID" value="LOC126885891"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659119.1">
        <property type="protein sequence ID" value="XP_050515076.1"/>
        <property type="gene ID" value="LOC126890261"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663073.1">
        <property type="protein sequence ID" value="XP_050519030.1"/>
        <property type="gene ID" value="LOC126893125"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G558"/>
    <dbReference type="OrthoDB" id="6433758at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028142132.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29422" checksum="9FCB58E06F8368E8" modified="2020-12-02" version="1">MTDNDQTMPNDNATPYEGNDHPIIARVGIKAPEFWRNEPELWFLRLEAQFRQAKITSDNCKFDHTVASLNSDILIEVADIVKNPTAGNAYTQLKARLLERYGISSDDRIHRLMELTLGDLKPTQLLHRMQALATDSISTQVLKNFWLDRLPPSVRSVISVLDGDLEELAKKADKYLRCSNFPVMAVTESPILDKAVAALNDQVSALSNRLAVAEERQQIQMVKSAKSSSDEQCYYHRRFGAQAKKCRPPCSFTKNDERAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5Q5</accession>
    <name>A0A6P7G5Q5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114336226</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028142352.1">
        <property type="nucleotide sequence ID" value="XM_028286551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050501073.1">
        <property type="nucleotide sequence ID" value="XM_050645116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5Q5"/>
    <dbReference type="FunCoup" id="A0A6P7G5Q5">
        <property type="interactions" value="788"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645116.1">
        <property type="protein sequence ID" value="XP_050501073.1"/>
        <property type="gene ID" value="LOC114336226"/>
    </dbReference>
    <dbReference type="GeneID" id="114336226"/>
    <dbReference type="KEGG" id="dvv:114336226"/>
    <dbReference type="InParanoid" id="A0A6P7G5Q5"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142352.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="32563" checksum="F57CB308D175EFA6" modified="2020-12-02" version="1">MRLRQNIFPKCVRDFFVTGFLLVMIPVVYYFELFVVLPRYYIQWSASYNFHFLTGTIILFNICTNLVAIAMCDTSIRGRVLPTDLKPDWKFCSVCESLAPPRSWHCSVCNVCILKRDHHCMFTSYCVGLENHRYFMVFLLYMLIATLYASFYNMRFISHFITFDFSWKSIFKIVFPLATLFMDWTQNQLFIFLILIVLFGAGFSGALLYFHVDLMFRSVVTHERNTVSKYDRGRLENVKLVLGEKWYLVWLSPWIESKLPCDGINWDKILSTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G633</accession>
    <name>A0A6P7G633_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bardet-Biedl syndrome 5 protein homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114334509</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140363.1">
        <property type="nucleotide sequence ID" value="XM_028284562.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511496.1">
        <property type="nucleotide sequence ID" value="XM_050655539.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511497.1">
        <property type="nucleotide sequence ID" value="XM_050655540.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050511498.1">
        <property type="nucleotide sequence ID" value="XM_050655541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G633"/>
    <dbReference type="FunCoup" id="A0A6P7G633">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284562.2">
        <property type="protein sequence ID" value="XP_028140363.1"/>
        <property type="gene ID" value="LOC114334509"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655539.1">
        <property type="protein sequence ID" value="XP_050511496.1"/>
        <property type="gene ID" value="LOC114334509"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655540.1">
        <property type="protein sequence ID" value="XP_050511497.1"/>
        <property type="gene ID" value="LOC114334509"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655541.1">
        <property type="protein sequence ID" value="XP_050511498.1"/>
        <property type="gene ID" value="LOC114334509"/>
    </dbReference>
    <dbReference type="GeneID" id="114334509"/>
    <dbReference type="KEGG" id="dvv:114334509"/>
    <dbReference type="CTD" id="129880"/>
    <dbReference type="InParanoid" id="A0A6P7G633"/>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028140363.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38354" checksum="146C204676476D84" modified="2020-12-02" version="1">MALQWEDKEVRFDIPYSKMKLINGEKVIDKLDNIEDTKGNSGFRGRLIITNIRVLWHSSSSPRINLSIGFGCILSTNTKMVNSRLRGTTQALQVLTLSRGTRYEFIFTNLVPGNTRHFISVMGVHKAYNSSKLYRELKLRGAVVHNKQLKILPLEQVVSTVSGVWNLSSDQGSLGTFIVTNVRFVWFADVNEGFNISLPYLQIDRIAIRDSKFGTALVITSSESSGLYVLGFKVDPEEKLKILFKELSSLHTVYTTKPTFGVEYKWTSSQNTKEHNNNIIAEFEAFDESKNEISNSISAYLADEGHSKDRLPAFCPELGLAVESIKEGYTLQKLWEVIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G9F8</accession>
    <name>A0A6P7G9F8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ RNA-binding domain-containing</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114339319</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SZRD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145754.1">
        <property type="nucleotide sequence ID" value="XM_028289953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G9F8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289953.2">
        <property type="protein sequence ID" value="XP_028145754.1"/>
        <property type="gene ID" value="LOC114339319"/>
    </dbReference>
    <dbReference type="GeneID" id="114339319"/>
    <dbReference type="KEGG" id="dvv:114339319"/>
    <dbReference type="InParanoid" id="A0A6P7G9F8"/>
    <dbReference type="OrthoDB" id="5373615at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="5">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028145754.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17965" checksum="F5B64E1334019BD6" modified="2020-12-02" version="1">MGPIMASKQQEIEVLENWEEIEETDVLEKKFNKILAPSKTLDNKSTNGSIENSVKIILTGDDALRTQYVPPEPTVKILKRPSKDLNSNGDSKVYQPKKTLQQRELEYAEARLRILGEASPEKIEEARISIVKPNHLESINVIRMPRGPDGTRGFNERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAB5</accession>
    <name>A0A6P7GAB5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114339631</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ITM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146084.1">
        <property type="nucleotide sequence ID" value="XM_028290283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAB5"/>
    <dbReference type="FunCoup" id="A0A6P7GAB5">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657550.1">
        <property type="protein sequence ID" value="XP_050513507.1"/>
        <property type="gene ID" value="LOC126889324"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GAB5"/>
    <dbReference type="OrthoDB" id="9982095at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="10">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028146084.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35919" checksum="C0A22A59138EEF1E" modified="2020-12-02" version="1">MTILTKPFSEKKGEKDVAPLVFNEQTAPANAPEDVESQQRRMPRILIFPAGARPHRVTTVTTLCLLLTALTVVGIGIVGGKILYDQYIRVAHKRFEGWAQIPIKNELKSAYDGTEVDDTDAFLDKILPTENYNEMWNDDDTDFKHIFKDYFQENFEISNDEKYEKIDVPDFRDGRSGRFIHDFNTNTTGIIDITGRRCFVMPLNRDNVLPPKSLFDLIHKMWEGYYKVNTDLVRKNMRVIIPPITDTKTIGGYIASECDGLPIYKLEKYVGGVVKRSADKQSERFAQFAGQGVTQIEITNMDEVYAYEKSLISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCC9</accession>
    <name>A0A6P7GCC9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114336359</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142513.1">
        <property type="nucleotide sequence ID" value="XM_028286712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCC9"/>
    <dbReference type="FunCoup" id="A0A6P7GCC9">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286712.2">
        <property type="protein sequence ID" value="XP_028142513.1"/>
        <property type="gene ID" value="LOC114336359"/>
    </dbReference>
    <dbReference type="GeneID" id="114336359"/>
    <dbReference type="KEGG" id="dvv:114336359"/>
    <dbReference type="CTD" id="7354403"/>
    <dbReference type="InParanoid" id="A0A6P7GCC9"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142513.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10270" checksum="B5C9844D63CF345C" modified="2020-12-02" version="1">MVNVKLTIICQSKNFKMVNVMKGVLVKCDPAMKQFLLHLDETLKLGRKFIIQDLDEHHLFISADILDTLQVKIDDLMDQISFPLAEKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEL8</accession>
    <name>A0A6P7GEL8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 40-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114336382</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142540.1">
        <property type="nucleotide sequence ID" value="XM_028286739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEL8"/>
    <dbReference type="FunCoup" id="A0A6P7GEL8">
        <property type="interactions" value="935"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286739.2">
        <property type="protein sequence ID" value="XP_028142540.1"/>
        <property type="gene ID" value="LOC114336382"/>
    </dbReference>
    <dbReference type="GeneID" id="114336382"/>
    <dbReference type="KEGG" id="dvv:114336382"/>
    <dbReference type="InParanoid" id="A0A6P7GEL8"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000116">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000193">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028142540.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="69584" checksum="2142D8A62F9B7953" modified="2020-12-02" version="1">MEKQNKVKSRRKCVNPVFHLQTKDENDQHMTKDVIKKVRTTGQLNLSSRHLSEVPEKLFSIYELTNENEINIDLSRPVKEEEAWWNIKTLTHLDLSSNVLTNLPKQIGMFQDLVVLNLHDNLLTSLPEEISSLTKLTKLSLNHNKITNLPQGFFNLTELKQLFISHNCLDSVSKDISDLVMLEKLDLSNNVILNLPSGIGFLVRLTELNVSNNKLAKLPPDIVNLRALLKMDISHNSITQLPDMGELRKLQILYAQHNDIREIPGFFGCEQVHEIYFGNNFIEEIPLEFCENMNHLKILELRDNQIKAVPSEITKLAHLTKFDLTNNDIEELPNAMGLMPHLQSFKIEGNKLKQIRPDIIHTGTNRILRHLREKISDEELQILSVPSDVSYDCKIYPDRYTMRNGNILNLALKNISDVPEECFMEAKEANVSNVDLCKNKFVDIPHGLKLLSNTLTELNMSCNRISNVPEFLMDLTKLKFCDLSKNQLEDLPDSLSSLVYIRELILSNNRFKKIPNCIFQMVGIEILLMNDNNIEEIPIDNLKMLTRIATLDLSNNSINYVPPELGNIKQLRSLELKGNPFRQPRYAILEQGTESVLSYLRDKIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GHV5</accession>
    <name>A0A6P7GHV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="4">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Malonate-semialdehyde dehydrogenase [acylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114339045</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028145472.1">
        <property type="nucleotide sequence ID" value="XM_028289671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GHV5"/>
    <dbReference type="FunCoup" id="A0A6P7GHV5">
        <property type="interactions" value="1171"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653245.1">
        <property type="protein sequence ID" value="XP_050509202.1"/>
        <property type="gene ID" value="LOC126886359"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GHV5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028145472.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="55799" checksum="DE63CA3752935299" modified="2020-12-02" version="1">MIKSTVSPVATLLRRSYSNVAPTTKLFLDGKFVDSKTTEWIDLHDPATNNVVTKVPKSTASEMEAAVESSKNAFKSWSQTSVLTRQQLMLKLQAVLRRDLKKIAQNITLEQGKTLVDAEGDVIRGLQVIEHACAAGTLLQGESLQNISKDMDVVSYKLPLGVTAGICPFNFPAMVPLWMIPLALITGNTMIMKPSERDPGATMLIAELLNEVGCPPGVVNVIHGAHQAVDFICDNKDIKAISFVGSDVAGKYIYSRGTANGKRVQSNMGAKNHAVILPDAHKESALDQIIGAAFGAAGQRCMALSVVIMVGEAQQWIPDLVAKAKQLKVNAGHEPGTDVGPVISPQAKERILRLVAQGIEQGAKCALDGRNIKVEKYPNGNFVGPTILTDVQTNQVCYKEELFGPVLCVMSADTLDDAIKIINANPYGNGTAIMTTNGNHARQFVHETDVGQVGVNVPIPVPLPMFSFTGSRGSFHGDLHFYGKQGLNFYTQTKTVTSLWRKGQVDSRPSVNMPVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNT4</accession>
    <name>A0A6P7GNT4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nicalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114341087</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nicastrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028147672.1">
        <property type="nucleotide sequence ID" value="XM_028291871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNT4"/>
    <dbReference type="FunCoup" id="A0A6P7GNT4">
        <property type="interactions" value="2058"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659552.1">
        <property type="protein sequence ID" value="XP_050515509.1"/>
        <property type="gene ID" value="LOC126890544"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GNT4"/>
    <dbReference type="OrthoDB" id="5913609at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03882">
        <property type="entry name" value="M28_nicalin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011018">
        <property type="entry name" value="Nicalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="212"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028147672.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61804" checksum="D57C5DECB15691D8" modified="2020-12-02" version="1">MWLQEVEEVFKGYLPYYILIFLPIFIIVSPANPVLASSEFPVYRMPHYDLHGIPHGCRSAGINLEAKSLTNWNNARHCVVTNFKSLTVDSFKNIKSKAGALLAMLPEHLSTLSAEEYQHLLLLENIILAQEVTIPVYFVKYSPELKSIIEDVESNIEDNLSKSATEAMINSIAGNGYQIIISASTPTVRTDARIATIHGQLSGYSADGKIPTIAVVAYYDSFGVAPDLSFGADSNGSGVAILLELVRIFSTLYAEQKTRGRYNIVFVLSGGGKMNYQGSKKWLEEQLDSVDGSIIQEVSYVMCLDTLAANDSIYLHVSKPPKEGSPTSQFYKELKSAASTIQPSVSVEGVHKKINLADDILGWEHERFSIRRLPAFTVSTLKTHRDFRKSTIMDTWGNLNMERLVKNTNIVAEALARHIYGESYESVFGSSLKISRKNVESWANTISSEARSPQLISTKDNPLVASFKQTFNEFLREVKVTVAVPDKRDPDFQFYHNTGGTVNVYSVKPAIFDLVLTIAIVLYLVIIYFLIERFPALYKIACSFTANNKKIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTW7</accession>
    <name>A0A6P7GTW7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114340704</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028147275.1">
        <property type="nucleotide sequence ID" value="XM_028291474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTW7"/>
    <dbReference type="FunCoup" id="A0A6P7GTW7">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291474.2">
        <property type="protein sequence ID" value="XP_028147275.1"/>
        <property type="gene ID" value="LOC114340704"/>
    </dbReference>
    <dbReference type="GeneID" id="114340704"/>
    <dbReference type="KEGG" id="dvv:114340704"/>
    <dbReference type="InParanoid" id="A0A6P7GTW7"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028147275.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17582" checksum="EE2D2A3C0CDD095D" modified="2020-12-02" version="1">MESSSGISFDKHVLRWYFVCCCFLILKMSFMSIFTAVKRVIHKAFANPEDSKQMKVDPQVNENVERVRRAHLNDLENIPLFFVAGLIYTFANPGAAGAKAIFVIYVVTRYLHTFVYTVVPLPQPARALSWSTGYIINIYMAMYSLIHFLKSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZV0</accession>
    <name>A0A6P7GZV0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114344360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114344360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028150998.1">
        <property type="nucleotide sequence ID" value="XM_028295197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZV0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028295197.1">
        <property type="protein sequence ID" value="XP_028150998.1"/>
        <property type="gene ID" value="LOC114344360"/>
    </dbReference>
    <dbReference type="GeneID" id="114344360"/>
    <dbReference type="KEGG" id="dvv:114344360"/>
    <dbReference type="InParanoid" id="A0A6P7GZV0"/>
    <dbReference type="OrthoDB" id="416987at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028150998.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22420" checksum="44B92554700F8D6E" modified="2020-12-02" version="1">MPWSIKLFTLSQITYAPNVQRTFDWQVKNGEENKIEYGNIIDDIIENIIEEMVEEQPNPDYLFHRSVIKSNSASKKIRPVFDASTREKDKSALNQCLEKGVNLNELISPILLRFRRQEIGVISDIRKAFLQIEIHKTDRDFLRFLWIDNAGKEKVYRHCRVVFGISSSPFLLEYSLEHHFSMLLRRCAANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HA37</accession>
    <name>A0A6P7HA37_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114348100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114348100</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028154528.1">
        <property type="nucleotide sequence ID" value="XM_028298727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HA37"/>
    <dbReference type="EnsemblMetazoa" id="XM_050647264.1">
        <property type="protein sequence ID" value="XP_050503221.1"/>
        <property type="gene ID" value="LOC126882370"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HA37"/>
    <dbReference type="OrthoDB" id="6783352at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028154528.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28158" checksum="AC1FF217DA671BBC" modified="2020-12-02" version="1">MDFSRMKRTKRFRLGDLTDEQIEQLMNSVETDEETDYDSDDSVKDPDFVVDDIEKDVIAECLNEMENADTTDQFLDGLHISAFDVPSASSIFTGNNENYDEVGVDVEHQTKIRAENKAELQASTSSSRPAKRMRSPLPIHEEDGPSIEPSAGGFIGAALDAIQKSGPVISNITWRKKSMRLHINEVAFLGDSKLPPEVKCLKTPMELFSYFFTDKIIDLISFNTNLNAYRTNNGSGSQQNFQVTPQWFVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IDY6</accession>
    <name>A0ABM5IDY6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial ornithine transporter 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130710.2">
        <property type="nucleotide sequence ID" value="XM_028274909.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274909.2">
        <property type="protein sequence ID" value="XP_028130710.2"/>
        <property type="gene ID" value="LOC114326516"/>
    </dbReference>
    <dbReference type="GeneID" id="114326516"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="225"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130710.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34620" checksum="0C8B325709E37AF9" modified="2025-10-08" version="1">MENQSDSLTVLKTSGKQHVKDGIIDFTGGSLGGVALVYVGQPLDTVKVKMQTFPTLYKNMFNCFATTLKTDGVRRGLYAGTVPALATNVAENAVLFFAYGFCQKFMQHITGAQSIDELSTVTNATAGFLAAFFSSVAICPTELVKCRLQAMHEVNKQQAQLGKAVKSVGPLQLTAEVIRTEGVKGMFRGLVPTIVREMPGYFFFFGAYEGTRELLRKPDQKKEDIGLVKTMIAGGMGGGIFWTALFPADVAKSRIQVNNLNENMMKLIFKIARHEGIGALYNGLLPTVIRAVPATAVMFLTIEYSKKWMHHISRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMA8</accession>
    <name>A0ABM5IMA8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136337.2">
        <property type="nucleotide sequence ID" value="XM_028280536.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280536.2">
        <property type="protein sequence ID" value="XP_028136337.2"/>
        <property type="gene ID" value="LOC114331061"/>
    </dbReference>
    <dbReference type="GeneID" id="114331061"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="6">
        <location>
            <begin position="12"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="6">
        <location>
            <begin position="388"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="616" mass="66292" checksum="C34F44B431179B78" modified="2025-10-08" version="1">MTEETMTPLTFGILTVSDTCHRDSKKDTSGPSLKEEVLKNYSSVQVIQQIVPDEIEDIKSVLLNWSDEKKCNVILTTGGTGFANRDVTPEATRQVIEKDAPGLSYAMISNSLAITNMAMLSRAVCGIRGKTVIINLPGSKKGATECFGFVKSCIPHAVALLTDQKDLVVLLHQSIQTKGGGDGLGFTPSKVKIDKVASRSRKSPYPLIEVPEATQIVLTQCTPTDETEVVAFDRSVDRILAEDVYALAPVPPFRASIKDGYAVIAADGAGTRAIKEVAAAGDAPIGEVLKSGEAIRISTGAPLPPGADAVVQVEDTSIVQASPDGSLELVINIEIAPKLGQDIREIGSDVAVNSLVLNKYEQIKAAHVGVLAMLGKTEVKVFKRPLVGVISTGNEIGDPKEELAPGKIRDANKFTLMNLLKEYSYDSMDCGIARDDPDSVKAVLEKAFMNNDVIVTSGGISMGEFDVLKQVLVEDFGAKIHFARVNMKPGKPTTFATLTYHGKEKKFFGLPGNPVSCGVTCLLYIIPALRYMEHCANYEFPTIQIKNSPLVNNDSRPEYHRVQVSFDPTIGEFKLSSTGNQISSRLNSLVGANGLAIVRKGDPSTTLNVLLFDHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IN68</accession>
    <name>A0ABM5IN68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
            <ecNumber evidence="11">7.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="11"/>
    <dbReference type="RefSeq" id="XP_028137003.2">
        <property type="nucleotide sequence ID" value="XM_028281202.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281202.2">
        <property type="protein sequence ID" value="XP_028137003.2"/>
        <property type="gene ID" value="LOC114331600"/>
    </dbReference>
    <dbReference type="GeneID" id="114331600"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF43">
        <property type="entry name" value="ASCORBATE FERRIREDUCTASE (TRANSMEMBRANE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137003.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="212" mass="23896" checksum="44CD53E753867CB0" modified="2025-10-08" version="1">MTTSKERIFHVTEILFQQMIAVFVLLVLWQLFISNSPVNSKGTWHIILCVTGFALCMAEGVQIFRHESVVTFGNTREEKKLAHMIVMAFAFVCITIGISLKISQKEDSNRAHFTSTHGILGLITWIFSFITALGGVITMYFRHLLSPRVIKLCHILLGITTYALGVATLCYGLQYMYGTGRGWVALVVLLVVYATYSLIGPFKSIYNYLRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IP99</accession>
    <name>A0ABM5IP99_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137946.2">
        <property type="nucleotide sequence ID" value="XM_028282145.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282145.2">
        <property type="protein sequence ID" value="XP_028137946.2"/>
        <property type="gene ID" value="LOC114332359"/>
    </dbReference>
    <dbReference type="GeneID" id="114332359"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045358511" evidence="4">
        <location>
            <begin position="18"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137946.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="367" mass="41822" checksum="0A37A1806DC7019D" modified="2025-10-08" version="1">MIVNKILVLLFLPFCFGKSVEVTFKDVTFKGFSVFTEKFKKKIPSGNKLADFLPPKTVYDAIEMKEQHIPVLTKGSLADLDQLDELVIEYCGVEEVESGAISNVPNLRKLSLKGNAIKSIAKDVFSHLGISTLDLSLNQISTIHPQAFDNMPDLLNIQLADNFITQWNPEWLKNTPLLTRISLQNNSIEKLPAHAFKNMVGDKKYGKIDLTINLVFSHNKISEIDPEAFADLSRINNLWLDNNVLESFDENLLSGIKVNDLRLNKNNIKCLDGNLDKILKAETNHIDSNPFDCNCLEKIKEWSNKKKNVDFTFAEMECTAQRIKVKMTALEKRLKELKGERDIPKEVEEIEVFETKPKNRAIKFVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IPM6</accession>
    <name>A0ABM5IPM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138240.2">
        <property type="nucleotide sequence ID" value="XM_028282439.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282439.2">
        <property type="protein sequence ID" value="XP_028138240.2"/>
        <property type="gene ID" value="LOC114332619"/>
    </dbReference>
    <dbReference type="GeneID" id="114332619"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138240.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="482" mass="53518" checksum="40C310C9C2F98948" modified="2025-10-08" version="1">MDEDLEQLLPTTSEEVDNRNRIRPSWGIRHLQVLFYFLLLTYTYSMRSVLSVAIVAMNDNSTSSNPNIETYDWKNQSVVLSAFFWGYFILQVPAAQLGKKFGAKWILVGCASVDSVSCMLIPTMAKYFGAEGVIACRISQGLAQGGIPPLVHMLLGRWAPPSERSVLTTITYVGSVFGNIVALSVTGAICSSQFGWPVAFYLFAVLELVWIVMWILCGSNRPSLHKHITEIERDYIESSLGQKEKKVRNTPWKKIFTSSPFWAVTLAFVGANWGSSILLTQTPTYLHNVLNYEIKSNSLLSAAPYVAMGLCSVIFSPICDCMINKSIVSRGNARKIFNSIGTLLPALSLTLFGFIPKEHSYLSVALLIFNGGMTAGGFCGFQVNHVDLSPNHSGILMGITNSSTSIFSIISPLIVQYIVTDLTNQIQWRIIFMTAACVYFVTDIFFIIFASGEVQEWNDIETQPEIPPNEHNQDIENQSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IS20</accession>
    <name>A0ABM5IS20_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthetic protein 28</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140262.2">
        <property type="nucleotide sequence ID" value="XM_028284461.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284461.2">
        <property type="protein sequence ID" value="XP_028140262.2"/>
        <property type="gene ID" value="LOC114334422"/>
    </dbReference>
    <dbReference type="GeneID" id="114334422"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140262.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18807" checksum="7328C27A22997629" modified="2025-10-08" version="1">MDRKMLYAFRGWIAFVAFMDLGTAVRSYIEKRSFLSKTISDLEEYVDGEYTATRVLGVYSILKALVLIHCTLYIHYKPVVSLGICSLISNVVLYLTETVYFRAATFNFYVVFPCILNAVTLGGLIYLPYHLHIWEHQLDGDEDMLRAGMIKRKRFVRKNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISY4</accession>
    <name>A0ABM5ISY4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140985.2">
        <property type="nucleotide sequence ID" value="XM_028285184.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285184.2">
        <property type="protein sequence ID" value="XP_028140985.2"/>
        <property type="gene ID" value="LOC114335028"/>
    </dbReference>
    <dbReference type="GeneID" id="114335028"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140985.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="626" mass="71860" checksum="770F2E0CFCE65122" modified="2025-10-08" version="1">MEVKQEVSEETCKIEIEYTDLDDFKCEIQEQEKSSTPHSTQDANDYLHLMEYPINTQIVHHGNKLIQFQEYQKTERGYPQEESKLEVMETLLMKHSSHEGSYMTQQDEGKALNQNVMEVIATGQKPYKCEVCSKQFSKSSQLKIHSNVHTEDKPYKCGICFKQFNQSSNLKTHLRVHTGEKPYKCEICFKLFSHTSALKLHMRLHTGETPYKCEVCFQQFSRAGLLKKHSQIHTGDTLYKCEICFKPLSGPSALKTHLRVHSGEKPHRCDTCLKQFYTKFELKRHLRMHTGENLHKCDVCFKEFSEPSTLKNHLRVHTGEKPFQCDICSKQFSEASNLKTHLRVHTGEKPYKCEACLKHFLTSSDLKRHFRTHTGEKLHQCEICFKQFTEAGTLKTHLRVHTEEKPYQCDICFKNFARAHVLKNHLRIHTGAKPYKCEICFKQFSQKHFIKIHLRTHTGEKPYQCEICFKQFSLTNHLKRHLRIHSGEKPYKCEICFKQFSRDSHLKVHYKVHIGKELNPFSVHGTDSCQAAFSDSASGTELCQTEFSDSASGTDPHQAVFSDSVSGTYPCQAVFSNSVSGTVPYPAAFSDSAGGTNPRQAVFSDNAIGTDKCQAVFSDSVHGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ITT7</accession>
    <name>A0ABM5ITT7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028141729.2">
        <property type="nucleotide sequence ID" value="XM_028285928.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285928.2">
        <property type="protein sequence ID" value="XP_028141729.2"/>
        <property type="gene ID" value="LOC114335658"/>
    </dbReference>
    <dbReference type="GeneID" id="114335658"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045511403" evidence="2">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141729.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="547" mass="61814" checksum="6BA5E91F45E9F83B" modified="2025-10-08" version="1">MRVILVINICVSIVTIVFARPEESKLEKEINTIETDVPAQLTDIKEILGDHPDDINRKKKSTVTTFCVEIRPTNERSFQVCEPSGNKEGYHNAGPYYQTGGGYENLKPQEAFSSGSSVQSKPAYSAPVKTFVSSGSNIVAKPDSPYGSFRSTKPDLFENEKPDRDKSDAARVRASKQEEPFRSTKPDLFENEEPDIDKSEPAHVRASKQEDNEKNVIEPTKLTNEPAPQQEEQKHVSPQQEEQKPVAPHQEEQKPVERKTKESIEEDEDGDDDKVSPFMRIAHPNYRYGYGPGYGHSGLVITCQPNLAGYAHGVPGGYTEKYHRGGGTAPSYNYKSASGYGRPYQNYKPQPQLYGNYKPYATRPIYRPPAQQYQTPAAYYPPAPHKEYKHYAPKTDYKPPAYSINYDTPYRAAAEEENENMDRSMLDTLDKERLTINKMEEVAEKRGYGSRFTDDIQAAKNGDARDADQELRKEDDETVGDAPGGWRNAELPNPDGRWRNPDEPMDWREAFSDQDNPEFEEQNVGKGTIDGMGVREGMSRENQIEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IW20</accession>
    <name>A0ABM5IW20_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028144761.2">
        <property type="nucleotide sequence ID" value="XM_028288960.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288960.2">
        <property type="protein sequence ID" value="XP_028144761.2"/>
        <property type="gene ID" value="LOC114338372"/>
    </dbReference>
    <dbReference type="GeneID" id="114338372"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044968112" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144761.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="58044" checksum="E0C5033146A9FD68" modified="2025-10-08" version="1">MKLVAIVAIFMCSVALTRGYRILGVFSYCGHSHFSLGYRIASELAARGHDVTMITCNPQNKGVKNLKEVSVEGFKRHLESFNADLADFGQMSFWGQLEWIKGLGIAYTEYVLTAPEVKQLWNSNQEFDLVVMEHFINDAATIFHHRFNCPLVILAPGPMSMMNNYLVGNLAPPSYVPSILGNYDAEMNYWERLSNTYKFIMGEIFMHTKFIPAHNELLKRVFPDAPDLNTILYNASLILITSHVSLIDAMPLQQNIKEIGGYHVTDPEPLPKNLIDFLDSAKNGAIIFSMGSNLKSSDFEPEKKRAILKAFSKIKQKVLWKFETDLPEKSDNVMISSWLPQKDALAHPNVIGFIGHGGLLGTIEAIYHGVPILGMPIFWDQMKNIEEAVRKGYGVKLNFADLTEETFEKSLNELINNPKYREGAKTRSKIMHDQPTKQIDEAMFWIEYVVRHKGAPHLRSQSVKLRWYQLYLLDVIALPILAVVILVFVIRQCVNFVVFSKKSSNKKAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IWH6</accession>
    <name>A0ABM5IWH6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145386.2">
        <property type="nucleotide sequence ID" value="XM_028289585.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289585.2">
        <property type="protein sequence ID" value="XP_028145386.2"/>
        <property type="gene ID" value="LOC114338960"/>
    </dbReference>
    <dbReference type="GeneID" id="114338960"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF10">
        <property type="entry name" value="IP19903P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045665707" evidence="1">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145386.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="193" mass="21638" checksum="51C2921DC7FB638D" modified="2025-10-08" version="1">MSTKFLIILILGVFKASAIQEEYLQWVDVTDDFPATAVKGGLNSEGQTTYIGRVYHTTADAEGYVPGTITNTSNSIDVILFNQCFTVTNKIQVLTTVGDDTKVDWISSTSEDFTSLFDSDLYFPVRGGWEQALGFNSTTYIGKTKFNTLQEVGKIFNSANIDIARNHILYFPIEDRVTYTSTYSVLVYYFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0C8</accession>
    <name>A0ABM5J0C8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028155553.2">
        <property type="nucleotide sequence ID" value="XM_028299752.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299752.2">
        <property type="protein sequence ID" value="XP_028155553.2"/>
        <property type="gene ID" value="LOC114349396"/>
    </dbReference>
    <dbReference type="GeneID" id="114349396"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44831" checksum="A3FBDC77283A10FE" modified="2025-10-08" version="1">MGFYPKKRSQRHRGKVKAFPKDDPSKPVHLTAFIGYKAGMTHVVREADRPGSKINKKEIVEAVTILETPPMVIVGVVGYIETPHGLRALATVWAEHLSEDCRRRFYKNWYKSKKKAFTKASKKWSDDLGKKSIEKDLKKIVKYCKVVRVIAHTQMKLLKQRQKKAHIMEIQLNGGSVADKVAWAKEQLEKPIPIANVFAQDEMIDCIGVTKGHGYKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPSRVSFTVARAGQKGYHHRTEMNKKIYRIGAGIHTKDGKVVKNNAATAYDLSEKTITPMGGFPHYGEVNNDFVMIKGCCMGPKKRVITLRKSLLVHTKRIALEKINLKFIDTSSKFGHGRFQTAADKAAFMGPLKKDRVKEEEKAAAPAAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH60</accession>
    <name>A0ABM5JH60_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497276.1">
        <property type="nucleotide sequence ID" value="XM_050641319.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641319.1">
        <property type="protein sequence ID" value="XP_050497276.1"/>
        <property type="gene ID" value="LOC126878544"/>
    </dbReference>
    <dbReference type="GeneID" id="126878544"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52489" checksum="5527AE79DB06D963" modified="2025-10-08" version="1">MASFKAEHLLTPELDYELKIRQLADPSLTTDRAKVIVLTGALKQASANRSHAVLSAFQLNFSDEVHEIEATLADLKTQISSFVGSHSDVLYGRLTSRLGHVSGRVHLLESVTEEEDTIKKSLNFKILNLEGELEFKVTPQAHSTPRNPSVSVNSFPFFKSAPIHKWGVHFSGGSNENVVSFLEKIECLRLARGNSEDECFSSAGDLFKDSAFTWYLNNRGSFTSWQLLVAKLKSDFLPYNYEDNLLDEIKSRKQAPQEKVTIFINEVVSLCKRLEVPFSESHIVRIIKKNLMPSYHPSLALTDILSIADLTEKCKRLEEVLSWSSEPISSVPSRSNVRNNESSYSGRPNYSRSGNVSTFNSRITCWNCRQPGHGYFDCSEPRGLFCYGCGRQGVRKFECEFCSGNDRRGGSSPLAPSPHQNTGNTLENPQDPGTSFSSQEAHASTTQTSQPPPKDKRPRNGRYQPKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JH72</accession>
    <name>A0ABM5JH72_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein R3HCC1L</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497284.1">
        <property type="nucleotide sequence ID" value="XM_050641327.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497285.1">
        <property type="nucleotide sequence ID" value="XM_050641328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497286.1">
        <property type="nucleotide sequence ID" value="XM_050641329.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641327.1">
        <property type="protein sequence ID" value="XP_050497284.1"/>
        <property type="gene ID" value="LOC126878551"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641328.1">
        <property type="protein sequence ID" value="XP_050497285.1"/>
        <property type="gene ID" value="LOC126878551"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641329.1">
        <property type="protein sequence ID" value="XP_050497286.1"/>
        <property type="gene ID" value="LOC126878551"/>
    </dbReference>
    <dbReference type="GeneID" id="126878551"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="79763" checksum="D643FAFA383B7B04" modified="2025-10-08" version="1">MNINADVEKVINTLSSKFHKIFCDRDFVCCVLEDFQVILRNRNRCCVVVFPLLGRNYLKAVQYQAELFDLVVFTLGSGKNCFVAVCDTKFLIKKEEIEEQIMPNNEEAGTGNNSKKKRPERQLYVPPAQRRLPISELPNGSKTDHGSSPKARKQISTTSRKKELPEKVKAVTETERPSYNEDNIRDAILNQFNEVSNFSYMWWKYELSDPLENEAKSVYSKSFMKKSRLCNLRIRNIYKLETTKSLYILSKNFVLWQPKFDVLMNNKKSYMKAISPSSLDQSDVKDSDTYYRASIMTNFCIEKTYIQMLEEFNIYCDVDVLIIKNNWEPKRAWSACYGDFFYINDNNCDEISTIEDMISDFLIISEEKEKELVGSKPEKEVENIISYVPENEKTNIIKEHVIKTNSEVPHQNVFPPQKNNLKNVIPNSNMNYLKNSINLTENVKVKNDLEEEKEIMRKAKENINRKTRPIIKYVDEANDTLKIEKNDVNNWEDLFDEEGQIQEDLLKEIVHKVGKNVTIVKAKEDYSDYFSKHVKIEELEHMVELYDFPASLETHDLIHAFNEIKSDAMYIKWVDDTHAILVLGSSTQAQRAINVQNPLIKVRPMVAASKSTLSIAYQNDLKPAMKRPATNLQTARRLITTHLGTKSGITSEISAKERNDLKAAREMKRLVKKNEQDAWDGNLRSSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHF7</accession>
    <name>A0ABM5JHF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine-protein kinase RYK-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050497372.1">
        <property type="nucleotide sequence ID" value="XM_050641415.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641415.1">
        <property type="protein sequence ID" value="XP_050497372.1"/>
        <property type="gene ID" value="LOC114330306"/>
    </dbReference>
    <dbReference type="GeneID" id="114330306"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF349">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54157" checksum="AD94BD50B19284FE" modified="2025-10-08" version="1">MNISSTGVIPTSVQTFSVQLLCTGSKNAEIIVEIQLSVSTHKKANATTLRFRRNKICLKNMGTSRNDSIKYEAGDMGPTTGSLYVAAACALALITLAVVVVSAVCVKRKSRNQEPTYMTALYDSNPHMFLRSGLGRPPSAESGSYATIASVHKGPPSPSPYATSDACQLYSSSDPGRVSYYASSQIMLISQMSMLDPRQTDPTKRLRTLSVSRDTVALSRLVQEGIYGRIYQGTYRTQQVTIKTLNDTASKRVVSSFLAEGSMLYGMEHKNVLTIICANLDDPKQPLLIYPFTNRGNLKKFLIKCRQKKNQIVLSTQNLVDIAIQILLGIMYLHGQHICYKDIATRNVVIDDKLQVKITDNSLSRDLFPNDYFCLQCQESKPVKWMALESLLYNQYTAASDVWAFGVVLWELTTMAQQPYPDVDPFELGVFLRNGMRLRQPLGCPDQLFALMNYCWAHHPAERPHVNQMLAFLQEFYTALCRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK22</accession>
    <name>A0ABM5JK22_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498288.1">
        <property type="nucleotide sequence ID" value="XM_050642331.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050498289.1">
        <property type="nucleotide sequence ID" value="XM_050642332.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642331.1">
        <property type="protein sequence ID" value="XP_050498288.1"/>
        <property type="gene ID" value="LOC126879258"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642332.1">
        <property type="protein sequence ID" value="XP_050498289.1"/>
        <property type="gene ID" value="LOC126879258"/>
    </dbReference>
    <dbReference type="GeneID" id="126879258"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="317" mass="35653" checksum="7329DF4E69CA8420" modified="2025-10-08" version="1">MAKVPNVKFNNGEVFPAYGLGTWKSKPGDVTQAVKDALDIGYRHIDCAHVYGNEPEVGAALKAKLADGTVKREDIYITSKLWNTFHRPDLVEPAVRTTLKNLGLEYLDLYLIHWPFALKEDGDLFPVNADGSTAYSTVDYVDTWKAMEALVKKGLVKSIGISNFNKRQTERILANCTIKPVTNQVEIHPYLNQQKLIDYLESKDIVVTAYSPLGSPDRPWAKPGDPQLLDDPKIKKIADKYNKTPAQVVLRYAVQRGLIVIPKSVTKSRIQQNFNIWDFNLTNADVAALNSFDCNGRICPYDDAVTHKDHPFVNDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JL34</accession>
    <name>A0ABM5JL34_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_050498648.1">
        <property type="nucleotide sequence ID" value="XM_050642691.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642691.1">
        <property type="protein sequence ID" value="XP_050498648.1"/>
        <property type="gene ID" value="LOC126879537"/>
    </dbReference>
    <dbReference type="GeneID" id="126879537"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044949632" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="31"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="550" mass="61164" checksum="2265CC30F9B520FF" modified="2025-10-08" version="1">MRVLKTSKVFLLISAIAIHESIAKRYEDDGTIVQLKEGRIHGHILKSEKGNDYFAFQEIPYAAPPVGKNRFQLAKPPKPWTDILNTTRNTKICYQAPSPFSNLKLSEDCLYINVYSPQKPGSNNLLPVLLWIHGGTFTYEAGTIEYFGPKYIMDAGVVVVTFNYRLGPFGFVGTNDGVIPLNIGLKDQRLAMEWVNKNINLFGGNPDHVTIAGESSGSLSVGYHLIGPWENGKQLFHAAIMQSGSILSGLLTQDDETNTALALGRIVNPQFTTNDTKELLNVLQNAEADDIQKAGIKIGVSTEPEGPFSYGGYAAFLSGNYKKVPVLTGFTSEEGGGAAFVKNEGILQLLDSDPSQLINSKINMSPEARAIAGNLRKQLYTHNSSFVEDFGAFIRHLSDAFCIYGICKQVELASANVTNYLYRFSYKGELGGAMDVLPFLPPDVDTVSHGEDNLYLWDDGSNSDLNKFPESDQLVLHKFVKLYTNFVKFYNPTPEIHPLLDNVIWQPSEPKSLRFLNINNTLSMQENPRQYKEVNEIMEKYMQPPFVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLL1</accession>
    <name>A0ABM5JLL1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498820.1">
        <property type="nucleotide sequence ID" value="XM_050642863.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642863.1">
        <property type="protein sequence ID" value="XP_050498820.1"/>
        <property type="gene ID" value="LOC126879678"/>
    </dbReference>
    <dbReference type="GeneID" id="126879678"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="259" mass="30411" checksum="A2338E066AA30BC1" modified="2025-10-08" version="1">MAKAIYCLKLFLFRDQMKMRKDNSKLNAEICVFVVYCYVEAWFSATNTTGAPLNDIYFLRKLVIFKNINENIATIAITKFLNHLWYLSEECAAMAIFDDRIERVEKIRMAQKIMECASKNIETVNEKEEENEETEVIEKKLSLQIRDVQNFVQKDLPTELLSANSLQLFKRFGICVEFLQDDPLNWENREDYRTGKNIISTLKCTNDIAERGVKLIEDYNEKMTKNEHQKQFLIQVVQEYRREFPVATKGGLLKSKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLS3</accession>
    <name>A0ABM5JLS3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050498885.1">
        <property type="nucleotide sequence ID" value="XM_050642928.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642928.1">
        <property type="protein sequence ID" value="XP_050498885.1"/>
        <property type="gene ID" value="LOC126879719"/>
    </dbReference>
    <dbReference type="GeneID" id="126879719"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="82" mass="9120" checksum="2A315DA97D64AB61" modified="2025-10-08" version="1">MSCDKVEMNARDFCTTCDLLQGEMDKCDLREELISLGYLTNQLQPKCSAAGFFTVNQLILGGLFSSVISYLIVSIQFNVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMH7</accession>
    <name>A0ABM5JMH7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499142.1">
        <property type="nucleotide sequence ID" value="XM_050643185.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643185.1">
        <property type="protein sequence ID" value="XP_050499142.1"/>
        <property type="gene ID" value="LOC126879872"/>
    </dbReference>
    <dbReference type="GeneID" id="126879872"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046453428" evidence="4">
        <location>
            <begin position="17"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="24432" checksum="815D324C54E9B941" modified="2025-10-08" version="1">MKLVIASVFLIAAASAAVVPVDPSHQPHVGQHVHNLPQAYQSGRPVEQSHPAPVSGHNQEHPRDFGHHLIPQNQQPQHPAHFGQHNKPVEPNSQPSSLVGQRSAGFGQHLDRPVTHKTGNEYKYDKHATNYHNAQESKILRYESEQDPEQGYKFGYHTSHGNEEVQRSEEAQIRRIDEEHASVAVQGVVEYVNHEGKGVRWTYTADENGYHPSEITVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQS8</accession>
    <name>A0ABM5JQS8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cuticle protein CPCFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500292.1">
        <property type="nucleotide sequence ID" value="XM_050644335.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644335.1">
        <property type="protein sequence ID" value="XP_050500292.1"/>
        <property type="gene ID" value="LOC126880474"/>
    </dbReference>
    <dbReference type="GeneID" id="126880474"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033778">
        <property type="entry name" value="CPCFC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17223">
        <property type="entry name" value="CPCFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046651014" description="Cuticle protein CPCFC domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Cuticle protein CPCFC" evidence="3">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Cuticle protein CPCFC" evidence="3">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="195" mass="20969" checksum="BB5FCDF59C0DA6DE" modified="2025-10-08" version="1">MFVKLVVLACSLAVATAVWNGPLAGGQPAHLYPAGVSPQACPNFPNCANPAVAANPQAPTAQQWGAPQQQWNAQPQPQWNQWNNNNNNNQWNQGQYNPSPVPQQWGNDATSRLNSGEYIGDGDYHGEGLVEARAPGYENQNLIAQWDNPNQGAPNQWNNGANQWNAPPNAHQAHGVGQIPAGVDAQSCPNYPFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRV6</accession>
    <name>A0ABM5JRV6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500673.1">
        <property type="nucleotide sequence ID" value="XM_050644716.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644716.1">
        <property type="protein sequence ID" value="XP_050500673.1"/>
        <property type="gene ID" value="LOC126880663"/>
    </dbReference>
    <dbReference type="GeneID" id="126880663"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64335" checksum="599E57A750258B54" modified="2025-10-08" version="1">MSDQNKTKRMATKGALTRLTTYFRSVENNEVIDLVDLEIRLSKAEELLDVFNEVQMLIETDDPDSARPTNTSNIKLPPLNLATFDGSFDQFLFFRDSFNSIINDDTSLSNVQKFHYLRLSLRGIAADTIKSLQVCDANYDIAWSLLIERFENKQLLVNNHIKALFNLPLVTKESNEGLRQLLDNTQKHLRALEVLKRPTKHWDDLIIYLLTTKFDNSTRRSWESQNCKDNLPVLDDLLKFLKERCRILESLDNYNDNKQDQNSPRYKGNKSETRAFVSNTENRFKCNFCNKEHKIYYCPDFLKLNPTNRLNNAKRLRLCLNCLGTCHRTKDCRSTGCRKCGKIHHTMLHFENSQSSNSVSTENNSSQSSLPSNVPNTGLQSNESTSTSNFSSTHHISSSVHTAIKPYILLSTAVVNVFDKFGNSHKCRVLLDNGSQSNFISEKFCDILQLSKEKINTSISGINQLTHNINFGTSLTFKSDINNFSKKISCLILPNITSNLPYIQINRSQLNIPTKLLLADQNFEKPGPVDLLIGADTFWDILSVGQIKLGPGLPIIQKTTLDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRZ3</accession>
    <name>A0ABM5JRZ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500714.1">
        <property type="nucleotide sequence ID" value="XM_050644757.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644757.1">
        <property type="protein sequence ID" value="XP_050500714.1"/>
        <property type="gene ID" value="LOC114327646"/>
    </dbReference>
    <dbReference type="GeneID" id="114327646"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="933" mass="106797" checksum="5D363F4DF50CD828" modified="2025-10-08" version="1">MPPKRKGGQEKKLEREKKKRCEIAKKCHSLDNLLNSYSVPSTSGVESDINTEKQEQEQKSEENLPVSETKFETELKLSEDSDDDIETSDESDSEANVKKALKDEEALLKLGQPEETESGNFFDRPDPNKLQLFFEFHPKVPVAQKDVPFNVEKAFTRNNKTKRKWLSYSEERKALFCTICLAYSVESNKDQSSAFVRGMSDWKHVYQRINEHESSISHGKNCETYFMYIKNQTIEKILFGNVVEMRNKKVASNRHVLDVIIDVIKLIGKRGLSYRGTANEAAYNLENENLDHGNFLEIILLLSKFDVILKKHLDAIVKKSKSYHNRKIKRRAGNFYTFLSKTTVNSIIVIITEIILKKISSEIQTATMFSIEIDSTQDISVTDQCSFVTRYVYNGTIHERLLAVVPCHNSTGKGFHTMIHDILVKNGLDEKNCIADSTDGAANMQGRYSGFSSFMVQENSNHVHVWCYAHILNLVLTDIFKSHIKAASFFSLLNCIAAFFKESHQRMGYWLDIGNNARSQKLQLIGETRWWSKEAALSKIFGNFNEPNKALYVDLIDILNTIENSQKIKPDARATAANYKAQLLKYENILIGHIFLKLFSITGPLSRYIQTTGLDLLKCNFMVNDSILSLKKMQRNFPDIEASADKFVGWAKLSFERRDFEIFIEEQLPEFRSKKKKKFFDEKTSDEIPVSPKENFRIVFFNVIADTAVESISRRFANNAELCRDLNILDPNNFEEIAKGELPENSLKILSEKLIQFDSSATPAKLKEELASFASNWKHIKLTIEDSYEINYARLDVGLDDSSSAQSDVDEDDCITKQSTKSRVCIESNKCQNCVICCYGSILKYNLFKGAYSTLVLAYQYILSLPISQVACERSFSTLKLIKNRLRNSLSDNRLESFMLMNIENDILSDINNDEIINRLGQTTKLMKDALMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSK6</accession>
    <name>A0ABM5JSK6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500921.1">
        <property type="nucleotide sequence ID" value="XM_050644964.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644964.1">
        <property type="protein sequence ID" value="XP_050500921.1"/>
        <property type="gene ID" value="LOC126880891"/>
    </dbReference>
    <dbReference type="GeneID" id="126880891"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="65064" checksum="FD91F82BA6F10693" modified="2025-10-08" version="1">MTGIHIKFQNCRGLNTKTAEFYKNCLEGNYDVVVAVETWLREDMVDGELVDINVFNLLRSDRNQEISGKTKGGGVLMVIKKEHKILKVTQHCSSFEILVADLKINNKLSIKLIGVYIPPDCKLQDYANCFELLQTHITDINNTFIFGDFNIAEIKGTENLDFTNGSAKFKSMIEFLNFNSFLLYNNVKNWQGKTLDQVVASADNINSCNVCQEQLPFVKEDRLHPSLEIQLSFTVSSFRQTDKLVGNRFNFKKANFDFMCDLMRNMTWEAVTEEIEVDKALDIFYSKVLNIFERSVPQYNIYKNYSNFPKWFTPDIKKLLKHKNNFRKLRHVSIYFNNQFIETRKKLKSLINIEHRKYIRQIEENIENEFNNFWNFISNKNSKSNQTEIFYFGGKEINHSDTANEFAKYFESVYSTDISSYNTNFTNIISNNNVLNLPSITSVDYDNAVKKLKPKKAAAPTESAAREHSLRVYYPVQQWLSLYQTTPDEQQIDPSKWGWKKLLVVSCQCQPLWTLHQTHYNGIFFENVKWAANAIVDARRRASISPLFPNLHIMRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWM6</accession>
    <name>A0ABM5JWM6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_050502338.1">
        <property type="nucleotide sequence ID" value="XM_050646381.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646381.1">
        <property type="protein sequence ID" value="XP_050502338.1"/>
        <property type="gene ID" value="LOC114349503"/>
    </dbReference>
    <dbReference type="GeneID" id="114349503"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
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    <sequence length="1141" mass="129620" checksum="72CDBD064BA81708" modified="2025-10-08" version="1">MNSYNRINGYESIEIHNLQEVYNESCDAVKFKIWGLREDRTRNFLYHFGCVILLGIPYLLFCFYPKLKSVKFKKAPLESATILLITDNFGVSEYVTVQNEIISLPNVTELRYFLYQHTKYIWHCETKSFVTLQVFMPAKTVDEYLNDTNGLTYEEYMSSLDLYGKNKIEVEIKSYSTLFIEEVLNPFYIFQVFSVVLWLCDDYLLYAFCVVALTIYSSVTSLLQTRRQSEAIRDLVESSKCHEVSVLRRYNVNDVSVNDMIIDPEDLVPGDLIVLRSSKYTMPCDAVLLTGECIVNESVLTGESVPETKTALHSGTETYDVDEHKRHTLFSGTTVIQTRYYNSEHVLARVVRTGFDTTKGLLVKSILFPVPVDLKFYRDSMKFVLVLFSVAMIGMTYCLYLYISRHAPLKDIIIRTLDIITIVVPPALPAAIAVGIGYSQNRLKKTGIFCISPARINVCGKIKIACFDKTGTLTHDGLEMNCVIPCTEAAFSDPVSDVRQLDVEAKLVQIMATCHSLTRVEGVLNGDPLELSMFEFTKWELEELGMTETARYDMLAPTVVGPTLNHNLNPLDINKTELPYEIALLRTFTFSSTFQCMSVICRDLRQPNMVAFTKGAPEKLLNMCREETIPENFLAKLAEYTAQGYRVIALGYKDLPESFKWKEAQKVKRDKIECDLTFLGFLIMHNPLKEETAPVIKILHNANIRTVMVTGDNILTAISVAHDCGMVRKSDKIFILSVETTIGDENQMETTRIQYEEVGRALVTDSIVSIDRDHYHIAIEGKTWSKLRTHYPDLIPSLLVTATIFARFKSDQKTELITYLQKLDYIVSMVGDGANDCGALKAAHVGVSLSQAEASVAAPFTSSIQNISCLVHLMLEGRCALVTSFVQFKYMALYSLIQFLSVLILYRAHSMIGDSQFLFVDLIITTSFAITMARQGPSGYLSSKRPMSSLVSAKNVLPLLLQIALCALFQMGSIYYLFQQRWFKPIPSNTIEPIIVSWENTVVFCVSCYQYIILAVVYSKGRPYREMLITNSWFLLSAVLLVIAVTWLVVYPCEYIADLMNVVYIPHGKRPENDFKYSLLAFPVLHFILASLIEVGMADREWLKKCIQFIKCKSIPKNRYKLLLREQNNYSPLINDTEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYE5</accession>
    <name>A0ABM5JYE5_DIAVI</name>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
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        <scope>IDENTIFICATION</scope>
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            <begin position="31"/>
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    <sequence length="218" mass="24912" checksum="DE24B6E289BCB0A7" modified="2025-10-08" version="1">MWRNHVCLRERKNRFSQVEFSQVFDGLLAKKGVPPKKNDEENSLSNLLNESQPANPPHSEIQLWASSESTEPSTSGKNPNNEVSIANQFQPQQPTRPKSREHHPGSNKKQDTIANLVVKIKTDEDLDFAISKALDRRKIAQQIVDDLSSTIKESQTLNQNYKKNQQQTLEIDAELKIAEQNVQALKAQRKKLVNAKASMLPKIKRMRKLLLQDTHPYN</sequence>
</entry>
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        <property type="entry name" value="Gas2-like domain"/>
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        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="13"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Desmoplakin_SH3"/>
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        <property type="entry name" value="PCN-like_spectrin-like_rpt"/>
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        <property type="entry name" value="Plectin_repeat"/>
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        <property type="entry name" value="SHORT STOP, ISOFORM H"/>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="63"/>
            <end position="186"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="7880"/>
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            <begin position="7881"/>
            <end position="7916"/>
        </location>
    </feature>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="coiled-coil region" evidence="7">
        <location>
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    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
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            <begin position="5522"/>
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            <begin position="7"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50021"/>
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            <dbReference type="PROSITE" id="PS51460"/>
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            <dbReference type="EnsemblMetazoa" id="XP_050504692.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
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    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="8319" mass="942892" checksum="FE2617427B48FC4F" modified="2025-10-08" version="1">[encoded data, 8319 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5I4</accession>
    <name>A0ABM5K5I4_DIAVI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
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        <lineage>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <dbReference type="Proteomes" id="UP001652700"/>
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</entry>
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</entry>
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            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="712" mass="80691" checksum="87264C994C48375D" modified="2025-10-08" version="1">MAYRPRSMQESTQEYSVETTTYETYEYETTFSVSETSKLDHFVLPPRTTILALSQSGGDKEEDKKYVVTNHGKADLFVEVVHLNNQDDAPQWFVVQPDQTTEIAIEDSLEQSVLKVSNNSYDQEVSFSAEGGLVIDDLENNIEELLDSDETEVEIVVLENFSLSPRTAVTVLSQNVEGSDEHPGKYTVTNLGKAAFDIELKRTSPVQTLELHRKTVEPNTSESFELTAQFQSTVLEVINTSHTEDAVFRAEGGDVIEDLEDLVRNIDEQKETVVTHILTTLESFHLVSRSSVTALMYDPNDVTLSEHHNFTVTNNGQSEIEVEVTYTDSDDRSNDQYRLVKPNETVVIEHNKDAGVALLNILNRHYTEVAIITATGGRVVRDIERKIKQLVSDEHSVMLVNNFHLAPASSVVVMHQVGRYRRRPMYPAGHRKPQHVMVRRPQYHPGRRPACKPAVARPCKPAGSPTGPGRRPFRRPACRPMIRPGHLPGQGGHPAQGGHRPAQGGHHPAQQQHHPAQQQHHPAQQQHHQGQQQHHQAQQQHHPAQQQHHPAQQQHHPAQQQHHPAQQQHHPAQQQHHQGQQQHHPAQQNRPQVGQCRPMRRPRVVMRPAMLRKPIVHDRYTVVNHGTHAFTAQIVHVNGRNQEVVRTQVVQPNETQVLLLEGINGSSLKIVNENETDYAIFSVEGGEVVYGFRYMVRPLRRRPGARRMFWGF</sequence>
</entry>
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    <accession>A0ABM5K7S3</accession>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="53"/>
            <end position="125"/>
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    </feature>
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        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="186" mass="23812" checksum="940F7D196D6EAE48" modified="2025-10-08" version="1">MYRDKHYGKTKEERRRDTRTYLGQTYIITNENKKKNYKNTNKQERENYTRRYQYRKDTNTKKHKTYERTYHKNRKQRNRGAQQAQQGRKNKKWTVTYNHRERSRRKKQWTQVTYNRRERSRRKKQWTQVTYNLRERSRRKKQWTQVTYNRRERSRRKKQWTQVTYDHREQQKNSVPDAKFSEIYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9G4</accession>
    <name>A0ABM5K9G4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein 15-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506825.1">
        <property type="nucleotide sequence ID" value="XM_050650868.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650868.1">
        <property type="protein sequence ID" value="XP_050506825.1"/>
        <property type="gene ID" value="LOC126884734"/>
    </dbReference>
    <dbReference type="GeneID" id="126884734"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045119592" description="Leucine-rich repeat-containing protein 15-like" evidence="5">
        <location>
            <begin position="18"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37579" checksum="6E8AB70F39132A09" modified="2025-10-08" version="1">MTLKLFLLLHMVGIITANEGPIPGCEEDSLDAYSKFSTPGKDVVCINITLEGNTSLTSEYKSWSIRTVQLISTKGALSSKTLEGYSLVANVLIYKSNISEFSLTMHFLQSLLVMESIFPNVTRENFSSMYFLFSLAFHSNLGVTFEENCFHDLVFLKNLTIFNQTFTKITPNTFKHLKELQTLVLNANGLRHIHKNSFLNLEMLRELNLENNPIEYFKINVSGLTRLEKLYLINTNITNFNIPFFYPLRHMNTLGLPSSCWLTLKLPELAIGFPNLRTVLINELDKNTANLTEEIDMMEYAQLVVKRVKKVDPIDTSILIEYIHIFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KAS7</accession>
    <name>A0ABM5KAS7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507299.1">
        <property type="nucleotide sequence ID" value="XM_050651342.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651342.1">
        <property type="protein sequence ID" value="XP_050507299.1"/>
        <property type="gene ID" value="LOC114340251"/>
    </dbReference>
    <dbReference type="GeneID" id="114340251"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="14">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="499" mass="56500" checksum="7DEC500085ED2C1F" modified="2025-10-08" version="1">MRNVGMLPSRVKLTQGCKHFGVNMAEEMMDDIRDSRFWQNVTNKSLDFNQQHSPENYMLVFEDIDQFFNKINISNGNDSEVTSVLNCTNFPLNFSNASCEVDGRLETSHHNYWALILILFPVFTLFGNVLVILSVFRERTLQTATNYFIVSLAFADLLVAVVVMPFAVYVLMTDNKLAASTKQDFKNFKVTDKSFTTVCFNTVTEHTNLSADSCDPTYPHPFPDDCRKFYICTVNGPVLQNCDPGKFFNPATHICDYTQRAYCAETTTEISPTTADFSNFFSKFKNIFSAAKNQQNNSIVENGDVNPTKTEATELPTTTTTTTTTTTTETTPEIATVETTEEMTTTESNSLNSTITLENRLLTDTPESETISEISTEPLPTPTISPALKRTDTNLSSFKKLVTKDSSKGHQDIYINNPYFIYINNYNHFVSGRSAPRPELINQQNRRIRYNDRRRRPASLLQTVGKFFSNLVDQIRRPPGSDYYDDYDGGNGSDYSYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC04</accession>
    <name>A0ABM5KC04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidoglycan recognition protein family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507716.1">
        <property type="nucleotide sequence ID" value="XM_050651759.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651759.1">
        <property type="protein sequence ID" value="XP_050507716.1"/>
        <property type="gene ID" value="LOC126885273"/>
    </dbReference>
    <dbReference type="GeneID" id="126885273"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="3">
        <location>
            <begin position="322"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="460" mass="51786" checksum="1878F79CA4BE0C35" modified="2025-10-08" version="1">MEELFIESVREYPFLYDASDSSYHDSKKKDKTCVQISENVDQWTGLEDKSSAPGEDEKKNESTSNTLENINLTTHEEDDPETDDDDPLKEGETAPLLAPNEDSKESKPDTPASKPLALNLDNPGNQQIGTELVTKSDNTMSKPSNDNPFNKPLIDDPAIKPPTDNPLNKPLNGDPASKSLNDNPLNKPFIGDPPSKSPTAPNLENPGNQQNGTGFVSKLKSVAENFLSSSDSSRPTEYDPESLDNEESTPLLSGIPLNRRFLDRLWLVLFIILIVLAVSIGAFLLIWLGQTQSESGFFNYILKNQWITLEAGYESPNHMRKLKLPARSVFLIELNSMDKTVCREAESYENCVELLRKNQMKYGHEPDILYNFIVDQDGSIYEGRSWERCSCKGSFTDEDITIAFLIDHNFIIEAVPRYVFNFLNQATVDQKLDPCYKTFVYNGTILYVVSDYIKSHRNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC17</accession>
    <name>A0ABM5KC17_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507731.1">
        <property type="nucleotide sequence ID" value="XM_050651774.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651774.1">
        <property type="protein sequence ID" value="XP_050507731.1"/>
        <property type="gene ID" value="LOC126885279"/>
    </dbReference>
    <dbReference type="GeneID" id="126885279"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="182" mass="20458" checksum="0CA729E37C51E1F9" modified="2025-10-08" version="1">MDHHLKCQLCGEKLQVTSNCLCTLGEHLLAQHPDVELTFFTSLENLLSWKLDLGEKARECNRKVISCRKLSAAKITKSSRSGKGGYKTTVETWKPAQLELACPQCRKKGQPSMRKHKNKFTNTSLGAFCMLSCWPACFLPFIVQKKSTVELYCRHCGSFLGEYNRATGTLSCVCSKRSNKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCP3</accession>
    <name>A0ABM5KCP3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GATA zinc finger domain-containing protein 14-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507962.1">
        <property type="nucleotide sequence ID" value="XM_050652005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652005.1">
        <property type="protein sequence ID" value="XP_050507962.1"/>
        <property type="gene ID" value="LOC126885435"/>
    </dbReference>
    <dbReference type="GeneID" id="126885435"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="43229" checksum="321026BAD80D67DE" modified="2025-10-08" version="1">MERNIEIQKYNLEAKIYEERRKTEEKLDDMLQNIQTNNHQIRNVEQRIEDISQIRDIGRPYLNLTNETGIKFSGNIKNLHPRVYINSLKHKLRSVNNINDIKDYIRMTLSDNAATWFASIENDLDNLQTFENKFLNYYWGELEQARFREVLYFGKYNRNLSLNTVDYALKLITVAKYLEPPLREDETVLNVSRHFDADVVQTVTVQNIQTVDSFINFIQRVQRGYITSNNSKNRQSYNNNRYGSNSQNFNNNNNTSYERQGNRENFNNNTNDNRQERQGNRENFNNNNNYNRQDFNTRRNAQRYNYNRQVNYVRGQSCEDSQRNSTWQENMNSRSEISERHRELDPNDQTQSDNPNNPNFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KD04</accession>
    <name>A0ABM5KD04_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">General transcription factor II-I repeat domain-containing protein 2A-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508073.1">
        <property type="nucleotide sequence ID" value="XM_050652116.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652116.1">
        <property type="protein sequence ID" value="XP_050508073.1"/>
        <property type="gene ID" value="LOC126885534"/>
    </dbReference>
    <dbReference type="GeneID" id="126885534"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31103" checksum="AB67ED605BDC380D" modified="2025-10-08" version="1">MSAIKEVQLSRPTVTRRIEIMCKNLEIQVKSDILKCVYFSLQFDESTDMTDTAQLCIFIRVVFSDMSCKEDLLTMLPLKEKTRGEDIYNVFINFVEQYELPIYKLVCIIITDGAPSMTGVNNGFVALCRANEDFPSFFSLHCIIHQQVLCSKILNMDDIMKITTKIVNSIRARSLQRRLFKAQLEASDSAEHTDLLLHTDVRWLSRGKFLDRFQELLPEIISFLEELGDDTHLLQNEKWLSDVAFLSDLTNHLNVLNLELQGKNKTKVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDQ2</accession>
    <name>A0ABM5KDQ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_050508327.1">
        <property type="nucleotide sequence ID" value="XM_050652370.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652370.1">
        <property type="protein sequence ID" value="XP_050508327.1"/>
        <property type="gene ID" value="LOC126885676"/>
    </dbReference>
    <dbReference type="GeneID" id="126885676"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044963958" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="512" mass="58334" checksum="27D385E703054456" modified="2025-10-08" version="1">MKIFLAILTFWSIQKFGSTYNILGVFTFCQHSHFTLGFQLLKSLADSGHNVTMISCFPQQKPIKNWVDISVRVGTNQDQVLGILARGPELQTMTHWTKLNFMAALGETYSSATFEVKAVQALLKSNQKFDVVIQENFLNEAFAIFHHKFNCPSIMFVPTPTTFFSNYIVANPWSPAFIPSIIGEYSAEMNFWQRLRNTFEQVLGEYFIHHTEIPIQNKVLKKYVKGAPDLRSILYNTSLLLISSHVSFIDPIPLQQNVIPIGGFHVTPPEPLPKKIKHFLDTAPHGVILFSMGSNKGITFNVRQKKDMLKVFAKLSQKVICNVDFASIETPENVLVADWLPQKDILAHPNTVAFISHGGLLGTTEAVYFGVPILGIPVYWDQAKNIEEVVAKGFAVRLDAEDIDEQTFEASLKRLINDPSYRRNAKERSQILRDQSVNQRDQAVFWVEYVIRHKGAHHLKSAALKLKWYQRYLLDIILFVTVASVFIIFAIYYCIKLLASIKNQTKLKDKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDX6</accession>
    <name>A0ABM5KDX6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508368.1">
        <property type="nucleotide sequence ID" value="XM_050652411.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652411.1">
        <property type="protein sequence ID" value="XP_050508368.1"/>
        <property type="gene ID" value="LOC126885699"/>
    </dbReference>
    <dbReference type="GeneID" id="126885699"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="440" mass="51501" checksum="CCD79E834CB7738C" modified="2025-10-08" version="1">MVKMSFARAKRFVYKEPEVKVSPADYDIPCSLGKVFTYSSECQGYHTKNTERCSLGAKQLSRKSQHIQQFEDPTSANQRNCNCRRNLPIISNARNGSSYNERNFRRGLKACSTPDKKKINITDSDKMNERESIFTRYDTKRISFREKNSSYIKKIDKNINSRHNGKKPLNDIQFFNIEEFFEDDYHGYTSLEDIDSRNTEKDCVKDYTDFSRRNFERTILEKVENVSRDVNNLHNSFKEFKTDFLINQFQQKLNKIENTTNLTNAPSHRKSQLAEQIQNEVSNAIENLKTDFLSQQNSIVRDAILKIGSIAGDLYSNRERCNIQMEDLCYRVVSDLNKNILNLVDQDKTVEHETSLQTDNMELKEIDAILNPDNQFFHYEDICKTLTNHLQISQKELDDLKRDKTDIMIKSCNAHKEISKQTSVLRKFQEELTVLKNSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFD1</accession>
    <name>A0ABM5KFD1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleic-acid-binding protein from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508906.1">
        <property type="nucleotide sequence ID" value="XM_050652949.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652949.1">
        <property type="protein sequence ID" value="XP_050508906.1"/>
        <property type="gene ID" value="LOC126886106"/>
    </dbReference>
    <dbReference type="GeneID" id="126886106"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24520" checksum="1ED6454A7AD0352E" modified="2025-10-08" version="1">MYDLHCKFEVLQATRLNRRQVDENGTQYIPTKTCVVSFKSQVLPKYITINKILKEVEPYKQKVLLCFNCLRFGHTGGQCKSKARCDKCQESHNSKDCKKTDLTRKCFNCSGDHFTTNLSACQEFQRQKLIKDAMTSNNISYQDANKQFPRNSYAKVTSINTEQTTNLSCLKTFPPLNPNNYTPTQFPSNPINKMSTNNIFYNNNSNSTNSRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFQ6</accession>
    <name>A0ABM5KFQ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509029.1">
        <property type="nucleotide sequence ID" value="XM_050653072.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653072.1">
        <property type="protein sequence ID" value="XP_050509029.1"/>
        <property type="gene ID" value="LOC114337158"/>
    </dbReference>
    <dbReference type="GeneID" id="114337158"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="478" mass="53120" checksum="1BA346DBE7D88D99" modified="2025-10-08" version="1">MTYQTQNVTEEQAQEALGLLNKDVAIKKVPTIGKRHLQALMLCLLLSCCYAVRTALTVAIVAMTDPKSNSNKDIPTFNWNDKSLIMASFLWGYWIPQIVAGYISDKYGAKWFLVGTITVSATAGLLTPSAAIYFGSKGVMICRFLQGLSQGFLYPSIHASLGKWIPVPERSRLGTLAYSGASLGIVLSLILTGYICSTRYGWPMVFYLLNAITLVVVAMYIYIGSNDPSSHPTISEEEKNYIINSLNTATDRHNLIVPWKEMLTSNAFIALFITSICFNFTHWMFLTQTSMYLDKIMHFNLKSNSVLTSLPYLMEFLVGFVACFIADYLIAKKTVSTTNMRKIMNNIGMFIPAVAIFLLTTTGSNDQNYVILSIILVSGSHGSGKSGKVVNHLDLAPNFSGVMMGFTNGLSIGLSSFAPVLAQIIVKDQHNISQWRIIFYLTMGLNIFGVIYNTLFTSGKRQPWNEGKRRKEVKMETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KI20</accession>
    <name>A0ABM5KI20_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509768.1">
        <property type="nucleotide sequence ID" value="XM_050653811.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653811.1">
        <property type="protein sequence ID" value="XP_050509768.1"/>
        <property type="gene ID" value="LOC126886779"/>
    </dbReference>
    <dbReference type="GeneID" id="126886779"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="24"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="546" mass="62006" checksum="6668F5C8B1FEA19E" modified="2025-10-08" version="1">MKDKEEEDPVDLIFKDASMCSKYVIFMFLSLGFLAAYSGCVFTYVFLARDVKYRCLIEECEPSPTDTIYEPKWLKHLVPYTGSVPDSCHRYALRNDSCSTEATSGNNETFRCNKFVYQTKDVTLVHDFDLNCDENAWKLTMVGTISMTGELVCLAYTGFISDKYGRKTLLIASTLMSTVVGVIKSFSVSYNMYVFLEFVDSIFGAAMYYGAFILAMEFVAPRNRNIVNIVICSLYAFGGCYMGIIAWLFPYWRTMLRVLYFPRFICILFFWTVPESIRWLLSKNKISSIHNIVSRVKGLKDKEDPNLTKLLDAYYEAQTQLCAENTTVASEKFIDAIKHKSLLLRFVICCFIWVTVNFIYYGLTLNSVDLTDDIYLSFIVSCLIEIPGYIIYYVVNEKIGRRLLTSVTFILAGLACLAVGFIPQDIQWLRLSLYLVGKCSSTVTYTVIFIYTTEMFPTTCRHSMLSICGMMGRLGSLIAPQIPLMARVSEMLPLVLFAIMGSISGTLALLFPETLNTKLPQTIQEAINIGKRDKRNARRDSAPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMU5</accession>
    <name>A0ABM5KMU5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050511510.1">
        <property type="nucleotide sequence ID" value="XM_050655553.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655553.1">
        <property type="protein sequence ID" value="XP_050511510.1"/>
        <property type="gene ID" value="LOC114330861"/>
    </dbReference>
    <dbReference type="GeneID" id="114330861"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042982">
        <property type="entry name" value="GBX-1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334">
        <property type="entry name" value="HOMEOBOX PROTEIN GBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24334:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN UNPLUGGED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="236" mass="26657" checksum="33D59B77CEC09058" modified="2025-10-08" version="1">MEMPSEQIMIKSDSEPVTKPVPRPFSIEALMSDCGPRRNTHFVPWEPQHQFVHNNTKDTDSEESVEMDLVQDLSNRSQKDGNSDIDDDLDESHSAEGSAATKARRRRTAFTSEQLLELEREFHAKKYLSLTERSQIASALRLSEVQVKIWFQNRRAKWKRVKAGLGSGPHQGVKNSHQKSKLVVPIPVHVNRFAVRSQHQQLERALGDLAGRVLASHAALRAGLDLHGFHTQAPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNA2</accession>
    <name>A0ABM5KNA2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein yellow-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511664.1">
        <property type="nucleotide sequence ID" value="XM_050655707.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655707.1">
        <property type="protein sequence ID" value="XP_050511664.1"/>
        <property type="gene ID" value="LOC114335682"/>
    </dbReference>
    <dbReference type="GeneID" id="114335682"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF19">
        <property type="entry name" value="RE55542P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046059617" description="Protein yellow-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44725" checksum="17BE4FDD51FE33E6" modified="2025-10-08" version="1">MSTTASAFYLICCFQMVLNVRLDVINQWNFLDFDLPFNFDYRDVKPENTLFTGLEVTADRLFLAMPRLRAGVPATLATIPRNTPKGSSPILRAFPDWSFHGAARGDVNCSNLISVYRMRIDSCNNLWVLDSGVLNSLDEFTRVCQPKLVVFDLFRDQILRTVYLPSGVLRPSSLLTNLVVDESIQGRCDSSFVYMTDTAAPGLIVYDGLRDTAWRFTHPTMFPDPNFGDYNINGESFSLMDGIVGITHSPKLATVYFQPLATDRIFSIPTSTLIKGPPAEFEKLPIAFVGKKSSQGLGLTLNLLDETIYFSPLTETSVASWNPLTNGQTLLAYDPDQLQFCAELRWKNDGYLWILSTRFQRFFLKTVSEQELNLRIVRIPYRKNTIHRGVNDLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNA3</accession>
    <name>A0ABM5KNA3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein yellow-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511653.1">
        <property type="nucleotide sequence ID" value="XM_050655696.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655696.1">
        <property type="protein sequence ID" value="XP_050511653.1"/>
        <property type="gene ID" value="LOC126887829"/>
    </dbReference>
    <dbReference type="GeneID" id="126887829"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF7">
        <property type="entry name" value="GH10609P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50787" checksum="BBC268D6EAD1FBF9" modified="2025-10-08" version="1">MKTLENPGLLPLVILCDTVFSKQEFTTVYKWKQLEFDYPSALEREQAIQNGNFDPAKLVPIDVDVYYARHFVDNKMFITIPRNKPATPASLGTISGKKINENPVITPYPNWDWHLNPESCNKNRIVSVFRVMVDECSRLWVLDTGVLGTRMVCPPQLLVFDLKSDTLINKYEFPSNQYDLRSMMVTPIVEVLDRTRFCRNTFVYIADCQAFALIVYDFNANKSWRIIDKTMFPYPTYGTYTILDDRFELMDGILGMSLSPISDGIERKLFYHAASSPTENWVYTAHLRNESLFSVDQPKLFHTLNGQRKTQSFAEAIDSNGILYYGLVEDIKIACFNTKSGYYGNDGWATDIVADNPVRFQFPSGMKISKNKRQEDELWILTSRFQKLLTGSLKTDEVNFRILAVKIDNLIPGTRCQPTNKTNEDDVYNVFIHIYNSNQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KQJ7</accession>
    <name>A0ABM5KQJ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 15-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512462.1">
        <property type="nucleotide sequence ID" value="XM_050656505.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656505.1">
        <property type="protein sequence ID" value="XP_050512462.1"/>
        <property type="gene ID" value="LOC114331358"/>
    </dbReference>
    <dbReference type="GeneID" id="114331358"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42455" checksum="C34E7E0B079D3609" modified="2025-10-08" version="1">MLNSNYKVSDMDVTLIINLFISATLISLSRSEPICIVDTSDNSNLVCKDVSTDFPDNMYYGNKNLQCDNCHITVFSSSTFKHDNVLLSINISHSGLRAIQPSAFKHLGNLQNIYFQNNMITNVSAGAFEGLRQVYEINLKNNLIVDLTPGFVRDLEVTYLSLANNKLSEIPNYAFKDVVVITNLILSQNKIKKLNYDSFSGLTYLEYLELDNNNLCYIPIGVFKNLKDLSYLNLANNKLSRFSLGTFSGLSSLTALVLANNSIKNFEGNELLPMQSLLRLDIKGNNIYYLDAHLIFSAAPTIKFISIEDNFYSCSSLANIIRYFKEKKVRIETHTGFYDIQNINGVACIDGIVDEVTDKANFLRRASDEAQTSVIYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRM5</accession>
    <name>A0ABM5KRM5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512836.1">
        <property type="nucleotide sequence ID" value="XM_050656879.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656879.1">
        <property type="protein sequence ID" value="XP_050512836.1"/>
        <property type="gene ID" value="LOC126888534"/>
    </dbReference>
    <dbReference type="GeneID" id="126888534"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="24577" checksum="439F6CE1AD9D6B90" modified="2025-10-08" version="1">MEVSPNISSNLPLFDNSDIDIDQNIENLTCNALNGVSETPKAIAEKKKQNNMEPEHESEIVEKNKTKNKNKKAAKRQRPNECQEDEDSVAEMKKQLKEKDEEIKKLRNQIHQLNEKINGLQNTIINSQEKVIETIDKRFDELKNENQTTDIQINEKKSMTAIPKKKIEDTNNNIANTKNLPITPTTKTNEDFPSLPKKVGKDNSVPSTSKKRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRQ3</accession>
    <name>A0ABM5KRQ3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512869.1">
        <property type="nucleotide sequence ID" value="XM_050656912.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656912.1">
        <property type="protein sequence ID" value="XP_050512869.1"/>
        <property type="gene ID" value="LOC126888564"/>
    </dbReference>
    <dbReference type="GeneID" id="126888564"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="130575" checksum="A05A8C6B08A96AAE" modified="2025-10-08" version="1">MINETKYFTTSNSAIYRDTNLDEWFEKKVVEPINRDLEEFQERDSGWALKAVVNLGVNIIKFTPQLGSSYIDLPAQIKRQQACINVKNDDEACFAWAVISALYPCRNNSALMSSYPHYSQVLKLKGIQWPMTAKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTKNKKDKHVNLLLIQNKYDEQGPLKYHYVWIKNLSRLLSKQLSNEDGTKYFCDGCLHYFRSQEKLNVHKTCCKGRSDVLCDRCLQPFLSSTQLEAHINDCERINETAIKMPEESQKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVGYYFKCSYDDSLSFYKSYRGKDCMKWFADELNQLAEDVSTVFMCPFDINMTFQQESDFQAATHCHICEQRFSPSDKKMRDHNHLIPENNYRFAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIINDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSQYVFLPEEQFNLLTVKGIMPYDYIDSFDRFIETCLPPIEFFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLTDVFERFRSSCLETYNLDPAHYFTLPGFTWDAMLKYTKQELELLTDPDMHLFVERGIRGGLSQVCSKRRVHANNKYMASYDPSKPDSYLMYFDVNNQYGWAMSQYLPYGGFEWSDTNIDVLSIPDDSSEGCILEVHLEYPQHLHDYHKDIPFCPQSLNPKTMKPPKRPRELTKLMANLHDKERYVIHYRALKQALAHGLILKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTLEGVRRRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLIAVEMHRAEIWLVKPIYVGMSILDLAKTTIYDFQYGYLASRFGENFSTCYTDTDSVIVEIREKDPYEAMIHDCYKYFDTSDYILKITFTASLWLIRRYIGLRSKLYTTKAATTDADIKKLRGKLKEQEYEYDEVDNIIRNCGVTKKAKGVKKSVVNTKITFEDYVECLDTFTAKVTSQNLIRSDKHQAYSITQSKIALSPNDDKRHHIRGSYDTLPFGHYLIDTLEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSK1</accession>
    <name>A0ABM5KSK1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050513165.1">
        <property type="nucleotide sequence ID" value="XM_050657208.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657208.1">
        <property type="protein sequence ID" value="XP_050513165.1"/>
        <property type="gene ID" value="LOC114327386"/>
    </dbReference>
    <dbReference type="GeneID" id="114327386"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="135"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="285" mass="32986" checksum="D4656F646A49B27F" modified="2025-10-08" version="1">MSASDEPIFSNKDEEILYWKHLAAEYLQDAQRIQKESDEFIVESQQLDREYEATIDQDEKKIRELTLANNKAQNEIESLRNKLEQSNKEIGSLQNEVQNIKTEKLQMSQYIRDLEQKNDDLERARRIIEESIAGIETAFNSAVERNAILESEVDEKEGLKEKLQRLADETRDLKQELSVKEKERGPDNERILNGFQKAIMDSNRLKENETQTTPAKHDYQAPISPASRVMALNIVSDLIRKIGGLERRLEKSKYDYRDLSTNDNIRRSRSSTKNSPSPSLQGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSN4</accession>
    <name>A0ABM5KSN4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050513198.1">
        <property type="nucleotide sequence ID" value="XM_050657241.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657241.1">
        <property type="protein sequence ID" value="XP_050513198.1"/>
        <property type="gene ID" value="LOC126888826"/>
    </dbReference>
    <dbReference type="GeneID" id="126888826"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF50">
        <property type="entry name" value="RUNT RELATED A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="504" mass="54045" checksum="B9742EF01DF99043" modified="2025-10-08" version="1">MIGDWNASSTMHLTNTPSGTGGTTSTPEGNTSLIQDTYTKMTSDILAERTLNDFLSEHPGELIRTGSPLFVCTVLPPHWRSNKTLPVAFKVVALGDIGDGTVVTVKAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIMVSSSPPQVATYNKAIKVTVDGPREPRSKTSEMHMLSLLGQQQQFHFAFGQRPFPFAASDPLSGFRMPPIGNCNNMPQFGLSSTNSHWGYSTAGAYSSYFTPGALGSCAAPTSQFNTPALGFSGSTPDQSSTQDAFTTSSAVSSLIPEASTTDLDQHLGLVSAQNHTNHSHSSSHTSSLLVPRYSSNHTDFTLSGPRSLSDNSSAAESPVQDDLLNTQSTLGVNHVNNSSNFLHQNMSQSSYSTSNCNNSIYPVLPGLLYSQLYSAANQSHNFHSLHTHTTHAQHNDLQSVMDHLSTSNQRQMVNGTTDLLLSNNGTCAAAAARQDDGHNRGLSSNGSQRGPGQNGDAVVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KSY8</accession>
    <name>A0ABM5KSY8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WD repeat and FYVE domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513307.1">
        <property type="nucleotide sequence ID" value="XM_050657350.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657350.1">
        <property type="protein sequence ID" value="XP_050513307.1"/>
        <property type="gene ID" value="LOC114334541"/>
    </dbReference>
    <dbReference type="GeneID" id="114334541"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15719">
        <property type="entry name" value="FYVE_WDFY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2368"/>
            <end position="2495"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2523"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="2966"/>
            <end position="3007"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3349"/>
            <end position="3409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2340"/>
            <end position="2362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3097"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3146"/>
            <end position="3251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2343"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3159"/>
            <end position="3168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3185"/>
            <end position="3200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="3213"/>
            <end position="3224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3413" mass="383859" checksum="FDA10762A1FA7763" modified="2025-10-08" version="1">MNIMRKLRSGATNPSPASSSDLGDSPSSPHTQLGLMHLKKLFSEYTHPPHQLTEQEKDDKLYNMLPLFCKVFGSSPTCDMNEKFWDILAFCQQVSLLMVSEIRKRASNQSTEAASCAIAKFLEIENCEESSNGWMLLSTLNLLAAGDYTLVQVMSEVSVPSTLVKCLYLFFDLPELSEKEANTKDTNSDFTPKERRILLQKIFVQLLVRLCSNRIPSEELARKDDLRLLFTAITSSVASYNTMWRKSAAEVLMTLSRHGLTPLVVGYIHSNSCVAGCIQNMKKIPELAPLELVEMFVTLFCFLKDSSEVSSTLLDDFRQAQGYPFLSDFLLKFENDNSSEAQETIRNLVLMVTSLCMCGYIELKPSQASTGSLFQMQGFILPQPSGRGTSVRNIQAFRVLQNAFLKSNSSLLCSTILDAISSIYHSDNANYFILENQNTLTQFTEKIQHKPAEIQQKLFDLIEFLVYQLNFVPCKELISMSIFLKTHSLNYVDCSILCMQTLLNILKHNPIFKDVYREVGLLEVMVTCLTRYGSLLEDKKVSGTNAKDYKLVCRQEKLGELVVEALTILLTSNSSNANVLRECGGAKCVHKLVQYTECRNSILGIIKELVLTTGGDDDMTQLLHTLNSAPRTQLQLKIDILEALKLCLKESHRTRTVFRKTNGFVYVTSVLVALEGRLSQRESNPEVLQLLSIVFQTICTAMRFEPANAKFFYHEVCRTSLCDTVRLLGCFSGEKVSKISEIDFETTSNGFQEVYQNIFVGPVTNPEIPEEISPSLAYTTIVYRLLYDLALDLFDKNINTNIFSSKSPPLSRDISIQGDINGKRSNVNSLNLSPPTPDPIIVHPGVVVCMLQLLPCIKDDHFEMYLSLQLFIAEIIKSLVRSERNQQVMCDKNFANYLLTIGSEPLQNENHPLHNSLQYMLERLAAQAIEAKDLRQFLRLGNPLCCLPLGSNEPGGYPVPLTRIKTLVSMTTPKDFRAQSSYTLPPFVEFDMSAEGFGCLYLPSIAPQSPSAPSVVSTVDSSVLGGIGAGDRMFPPQTGLSYSSWICVDKFSDPRSDPHCVRLLTLVRNFSGAREDHLVCLSIVLSARDKAIIVSTQETHIPNHIGDWEPEGSGEHGARVWCPDILQEGQWHHLVVVLNRAVLKNSSFSLYLDGQQIHNQKMHYISQNPGGGAANLTVASSVYGYIGTPPAWRRYSRLCWKQGPCHLFEEVLPPNTVTYMYQLGPHYMGSFLAPILNNPDIGSLVTEEKVVFGLNAKAVSQLTLNKIRKVYSRTDNKSIAKQLGMSSHESATPIRILHNSAGHLAGSARTLGGVIIGYLGVRVFCPRPVATTIDAVGGCSVLLGLIAMAQDIESLYAGVKALVCVVKSNKVAQSEMDRRRGYQTLAMLLRRKRTLLNSHILHLAFSLVGTVDSGRESSAIPNRTAFQDLLCDLEVWYEAPGELLRSHLEHLYELAAESNEKRNNSWVMRELQLVEKLLHICPDVKHPATRQVLFSLLSVLLSNQPRHNDLLLFGQFMASMLPSTPEESEKALELREGDAEREGEGEHILLRNRCLGLLHSLIFASRNHIGEEIVKTLGFDWLLLFMQQNLHSSTVIWAMRILVAICSSPSLLGRFRDGLNNGGWLRYTEQVTHNKMAVVLGNQLNNVHCNDFKSEALHIPGFKFLSWLLPYHLEISELYFLITALMMGQPAKLLPAEMRFDLDSVWAFLWGGSINHQPISSLIPRISLCSEAVVVLLGMAKAMAHAEEGSLPPWLQNHPISIVQVLFQLYHNMPEFMPIFMSSEVLSALASVLFLPITNSDSIDSSGASTPAGDEIDPLMMMTRAHDDQNLINHPVRQFIIDFIRVIVVDSLSLPLTGKNSPVIDLVLDAYPENSSNSQQITYQTEILVTLMDHLLAADMLVGDQAAIPIVPLLTAHIQNVTPNVFYLTARIVDKLWQGCLTKDPHEVFDFIVKLIGQAKRRTGNISLESLYHCLNRSILFLLSRPTDSIADQMSVLEALHKLTTNRLIVFGAGNHELDFIGCLSYCLLQLTSDMKIMLDSNMKTTWHVNPSSDLESRDEQLNCHQGKNLMAGAALRVWEELYVCKKPAIEEVFKVTFAQPHQNSKAPDLLLVRDQVFDASSKLWLNYVEGERKAVYRVPFELHNQIQSKIHKVTGGLTRLASRTKVKKDETIKVPIRIGKKRAFTWTYSHINLLKSLMEMRRQQHQNTSQHTQRYVHQEWLQTENDLTRERGLWGPPEPSSLDKWMLDMTEGPHRMRKKTMKNDLFYSHYPYRVEQERGLLKYKVATSYHSKEYYNAIQLRKHLGVSGMMEPERSDSVVEEPSPLPFAPALSQLARLRSDPDDLQEEADEEESSSQPDNQTLMRLLEANEKITYMFRCARIQGLDTTEGLLLFGQEHCYVVDGFTLLKNREIRDIESVPHNTNEYEPILPNPGSPRRSRAMRQCSKFSYDDIREVHKRRYLLLPMALEVFSGDGRNYLLAFPRKIRNKVYQRFMATATGIADSAQQSVAGQKRTANVEQATGLLSNLIGETSVTQRWVRGEISNFQYLMYLNTLAGRSYNDLMQYPVFPWILADYDSEELDLTDCSTFRDFTRPMGAQSPERLEQFKKRFKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRLEPFTQHFLRLQGGHFDLADRMFHSVKEAWLSASKHNMADVKELIPEFFYLDEFLCNSNQFDLGVKQNGVSLGNVVLPPWAKQDTREFIRVHRQALECDFVSQNLHHWIDLIFGYKQQGQPSVDAVNVFHHLFYEGNVDIDNIDDPLKKNATIGFINNFGQIPKQLFKKPHPCKKMAGANNRTSVIDTGSLVQAFSLPQPEKLFFHHLDNLRPSLQPIKEVKSPVGQILHVDRSVLAVEQNKVLMPPAFNKYVAWGFADHSLRIGNYESDKAVFVSESVVQNNGEILACVFPSPKSIVTAGTSSVVTVWGYEARKKSLTIKHSLYGHTDAITCLATSPAYNVIISGSRDCTAIIWDLSRGVFVRQLRGHAGPVAAVAVNDLTGDIATCAATWLHVWSINGDELASVNTCIGTADRMQQILCVAFSQTHEWDSLNVIMTGSSDGVTRMWSIDYVQVPDDQNPNSISSKPPIEPKSPKSPKSPKPNETVSKPSSIHHRLVKQIHVSSSSSLGSAGNLMKSGSESSLSEENTRRSSIDRQISNESSSKEWRSEQQDEKDTCSDTEEVAPPVAPARRRRSRVHCGFRKSEGGNSAENPSIDIDDGSGLRTSKSDTSLTDSFVLISETKKKSPNPLNSLRPGFKWQRQLVFRSKLTMHTAFDRKDNTEPASITALAVSKDHRSVYVGDTRGRVFSWSVCDIPGRAADHWLKDEGADYCAACSIKFSIYERRHHCRNCGQVFCSKCSRFECEISRLRILKPVRVCQSCYAALKTDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KVM7</accession>
    <name>A0ABM5KVM7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calphotin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514241.1">
        <property type="nucleotide sequence ID" value="XM_050658284.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658284.1">
        <property type="protein sequence ID" value="XP_050514241.1"/>
        <property type="gene ID" value="LOC126889735"/>
    </dbReference>
    <dbReference type="GeneID" id="126889735"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14036" checksum="DDDC79B990E7A681" modified="2025-10-08" version="1">MKIKTVSVASVYRTTTTTTINMVSKIIAFVAILAYAHAGVLTGSPVISAYSSPLVSQAVVPSPIVSSPLITRSLPIGLAAPAPLLTRSVGPVVSSPLLAPSVGPVLSTYSAGPWGGIAPLSSPLVAPLSAPVAAPWAAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWG9</accession>
    <name>A0ABM5KWG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibrinogen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514534.1">
        <property type="nucleotide sequence ID" value="XM_050658577.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658577.1">
        <property type="protein sequence ID" value="XP_050514534.1"/>
        <property type="gene ID" value="LOC126889875"/>
    </dbReference>
    <dbReference type="GeneID" id="126889875"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046728732" description="Fibrinogen C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="53"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="275" mass="31292" checksum="90861D1F81456FF6" modified="2025-10-08" version="1">MSVSTNYLKLALIVSLILSICGNYLDNDQQNRSVQEEIKESSPIFKRSAYYGKADGTPFKNCKEILESGVNISGIYEIQPIGSNKLINVTCDMETRGGGWTVIQRRIDGSVEFYRGWREYKFGFGDLNGELWLGLESIYHLTAFEANELLVELVDKDGISAYALYDSFAIGSEVEGYYLSTLKGYSGDAGDSLSNHLGQKFTTLDLDQDQKPDGNCAEIFIGAWWYNNCYESHLNGKFRNIRWPAAYKYKGIVWFGFKNNEYFLSQARMLIRPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWY1</accession>
    <name>A0ABM5KWY1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514694.1">
        <property type="nucleotide sequence ID" value="XM_050658737.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658737.1">
        <property type="protein sequence ID" value="XP_050514694.1"/>
        <property type="gene ID" value="LOC114334847"/>
    </dbReference>
    <dbReference type="GeneID" id="114334847"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="185"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41548" checksum="E0FE48214C5B35BF" modified="2025-10-08" version="1">MPIKKGNTLLYKGSNYLRQRLILSVLSGKPVQISEIRIQEDEPGLREFEVSLIRLLDKVTNGTVIELNETGTSLYFQPGLLYGGEIEHDCCTDRAIGYYLEALVMFGIFCKQPVKAKLKGVTANNIDPSVDLIKTSMIQTLKRFVLDDDDLDLKISKRGSRPLGGGEVTFRCPVRKQTRPVQLLKNGMVKRIRGTAYALRVSPAIANRMVDKAKGVLLNFIPDVYINTDQCRGKQSGNSPGFGIHLVAETTEGVHYSAEQVSNVVANNEDPSVPEDLGIAAAQRLLYEIYLGGVVDSTSQSLAILCMALGDKDVSKLVTGPLSEYSIWFLRHLKDFFGVTFKLEPFEEDESSSGQGSSKVLLTSIGIGYTNISKRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KX49</accession>
    <name>A0ABM5KX49_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514757.1">
        <property type="nucleotide sequence ID" value="XM_050658800.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658800.1">
        <property type="protein sequence ID" value="XP_050514757.1"/>
        <property type="gene ID" value="LOC126890000"/>
    </dbReference>
    <dbReference type="GeneID" id="126890000"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="25257" checksum="52471E16681D5CE7" modified="2025-10-08" version="1">METFENECTRLQIDKNTEKIEILRLFLEGSCVDWYRSMLIKYSINSDWDEWKNKFCDTYADKGWTPVRYAFEFKYMNGSLLEYALKKERLLLQINKSLNKKIMIDLIAIGLPNYIADRIDRDTLKETEDLFNGIRGLEHLIKMKTSEKKEIPYFKKKQACKICEKEGKGLRYHLESSCWYKSKSEVPKNQEVRTVNNHKLELELNETNPKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXQ7</accession>
    <name>A0ABM5KXQ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514978.1">
        <property type="nucleotide sequence ID" value="XM_050659021.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517423.1">
        <property type="nucleotide sequence ID" value="XM_050661466.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659021.1">
        <property type="protein sequence ID" value="XP_050514978.1"/>
        <property type="gene ID" value="LOC126890168"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661466.1">
        <property type="protein sequence ID" value="XP_050517423.1"/>
        <property type="gene ID" value="LOC126892038"/>
    </dbReference>
    <dbReference type="GeneID" id="126890168"/>
    <dbReference type="GeneID" id="126892038"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="217"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="452" mass="52623" checksum="344DB7F990C09215" modified="2025-10-08" version="1">MWRPWESDMHLPDENEPTDNLEDEDESAGSSTQQRKNLCVAEQNMVLDVFDGLSKKMNRYEAVKQTAILTKISCATVYRLIKTGSKSRKTRKDLGSSKKIQPHLLEPISETIYNMYAAKIMPNLNNIMAKLKEKHMVHDCSTKTLGRFLTKNGFKYKTVNKRQTIMESSRLIKWRNEYIEKILQYRSECREIYYLDETWFDSHETIDKAWTNGLSKCQIDVPHSKGKRICILHCGGQHGWVNDALLLSSKSIKDSSLDYHQDIEGTLFESWFENTLLPNLKANSVIVMDNASYHSRCIKKIPTKQSRKDEIQEFLIAEDLYFEDHYTKDQLIQVLHTKVVTKEHIVDKLATNNGHTVLRLPPYYCVLNPIELLWAQLKNHIRRNNTSPKDAQSVVELIKTEFKNISAQNWQNAIEHVKKIEKDYMKNVPALKKIIINLDESDDENDNDDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXQ9</accession>
    <name>A0ABM5KXQ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514962.1">
        <property type="nucleotide sequence ID" value="XM_050659005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659005.1">
        <property type="protein sequence ID" value="XP_050514962.1"/>
        <property type="gene ID" value="LOC126890155"/>
    </dbReference>
    <dbReference type="GeneID" id="126890155"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="135" mass="15495" checksum="C3F377B3CDCA0836" modified="2025-10-08" version="1">MEKKLVALGRIDKGESLKTTAASYSIGTSTVSDWKKNRTKIEEFCFKMIIKDSLDNWCKVNKAKNETLDDTLYVWFCAERERGLPVSGPIIQESALKLNKMLPDCEPNFTASQGWLDRWKKRHGIRQLSDVLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L088</accession>
    <name>A0ABM5L088_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515853.1">
        <property type="nucleotide sequence ID" value="XM_050659896.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659896.1">
        <property type="protein sequence ID" value="XP_050515853.1"/>
        <property type="gene ID" value="LOC114333318"/>
    </dbReference>
    <dbReference type="GeneID" id="114333318"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045114694" evidence="1">
        <location>
            <begin position="19"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="554" mass="62510" checksum="FD04CA15590A3F17" modified="2025-10-08" version="1">MKLLISFILLCVFQAVWTKSIVKRDCCGNSCSTPCNNNNNCNNSPCYNNCNSGNCNNNCNSRPCNSNCNSSPCNNNNCGSCNDRPNIPEPRDEVRPILVPFPQPQLSPSGGENTINNTNINNSTMELTFTNTINTVNNISMPISLNPSNENSITVHFNQVERTKEEKEIVQEDNCCFISERKCYANDTCVMVRRKECSDICWGILPVEPKPSPAPTTERPIVIVYTPPTPPPNPEPTTKGPTVIIYPPEPTHRPIPPPPNPRPVIIIPPRPCSANPQRPIYIPNWPQYRNIWEYYQYIQQPCTRMQPQPPVSIDPVPLPVPNLPRPSCSTPGYTLIYRLRPQSTPCNPTIPYVPYIPSPCTPHVPQSPCSELSSTQQLNNQPLILQQALNQLRSQNNQIQLGQPDIIPLQNNLNLQQFSQSDILPLQHNQLNIQQYPQPEIYPVKNAPQNLQQLSQSDIIRLQNNQLNFQQYPQSEIYPGKDAPLNLQQFSQPEMTNVQNSQVGLQQFGQPEVFPDQNSQLAFQPQIEQPRVFPVGYNQVAQRSNGLPYNLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0L4</accession>
    <name>A0ABM5L0L4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rap guanine nucleotide exchange factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515979.1">
        <property type="nucleotide sequence ID" value="XM_050660022.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660022.1">
        <property type="protein sequence ID" value="XP_050515979.1"/>
        <property type="gene ID" value="LOC114325085"/>
    </dbReference>
    <dbReference type="GeneID" id="114325085"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06755">
        <property type="entry name" value="PDZ_RapGEF2_RapGEF6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="277"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="410"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="528"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="747"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="858"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1395"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1144"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1418" mass="158242" checksum="31B81621E920BC1E" modified="2025-10-08" version="1">MREFESRSAHELGRDVVSPSRGGMTDWEGMWIRSLSKPPTCRSLQDLQVIYYGLSGLEALQTVRDSSLRALCKIVRYEKHLANDVLYYTGELSTCWYILLSGSVFIDGSMFLPRSSFGKRTGGSARRQNECFVLEPSEMIVIDYPDIEPRRIQNSPLMDHPQHRSMNIMFVDEYAQNIPRQNLYHKCSRGSHSSDTSSAYSGSDTMASTHSELDGDELDLTGLVESIVDSDEEDDLTESMDSLTVRDRVRDCLEKEPSERTEDDIEALLEFTQHLKAFTNMTLAVRRALCAVMVFAVVEKAGTIVMNDGEELDSWSVLVNGSVEVVIPDEPSQTLYMGDAFGILPTMDKLYHKGVMVTKQDDCQFVCITQSDYYRILHQGEENTRRHEEEGKLVMVTELRGSLEPGSNRRGHVVIRATADRLMQQLIEENSLTDPTYVEDFLLTHRVFIQSPLVVASQLLDWFKDTEVRDRVTRVVLLWVNNHFTDFETDPDMIEFLETFEQGLESEKMVGQLRLLNIACAAKARIRNVVLARPNRDEPLSFQILGGFERNFGIFISKVDKKSKAEDVGLKRGDQILEVNNHSFEHMSLARALEILRGTTHLSITVKSNLLHFKEMLNTPDNSPRPRSRKVSDITNLTKVPADPRARLSSVDGNIILGHDTPASQPITISSPAKEGKKQSFMTLGRLQKALMKMSIFPKNMINVGLGQDQVDSFNPPSTLGSNLYQSQSNPDLMSICYDDLRCTDYPEHVLKVYKPDQSYKYLLVHKETTAHEVVMLALQEFGMTDPSSNFSLCEVSVTDNQTIKQKRLQDDLQNLAERIGLSSRYYLKTNGVTETLVPDELAPELVRESAVHFLQLNAVEVAIQLTLLDFSIFRQIEPTEYIDDLFELKSKYGTPMLEQFASLVNKETFWVVSEVCAEHNPVRRMKIIKQFIKVARQCKECKNFNSMFAIVSGLGHGAVSRLRQSWDKLPGKYQRVFSELQQLMDPSRNMSKYRQLVSAEQTQPPIIPFYPVVKKDLTFIHLGNDSKVEGLINFEKLRMIAKEVRSLSNMCSSPYDLLTMLKLGGQPASNAMVALNQLTTASSNYHAQGQATVKRRKKSAAAPNPKKMFEESQMVRRVKAYLNNLQVETDEAKLHEMSLECESPATGGSSGPGSTRTKRHSSPAPSTTSSTSSASDERKPTAKFGSASPQAVRKLLALSEPNKTRPHQPRLPSHGLNQPSPAVRRAPSATGSYSSYGSHSSSSSGAGGRAMHERSHSDTPTPLPSVALSAESSSVTSLSNLPLRKTVTSGSVSSSDSGHSTISQVTTSSNDCHSYQPRCPSPPRHPPPIPGWLPARIGSLPPCALAVAVLPPLPIAFRNSNNGPGRRQPPAYSVAAQMARLHRLGRAHSHEGVTQGYHYHTDPDTDQDDDETQVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L103</accession>
    <name>A0ABM5L103_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516119.1">
        <property type="nucleotide sequence ID" value="XM_050660162.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660162.1">
        <property type="protein sequence ID" value="XP_050516119.1"/>
        <property type="gene ID" value="LOC126890981"/>
    </dbReference>
    <dbReference type="GeneID" id="126890981"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="87000" checksum="597B63C02C02E4AB" modified="2025-10-08" version="1">MSSQTLDMFVLDMVKKVEKVVMLLRTIEEFNKWIRFIKISINLVKKAIQNKSHHIKHREDCISWFVKELGLISKKLDDIYSNVVPMTPLTNLEENQFLNAELCYICTQPFSDDDIKCKDHCHRTGTYRGPSHQCCNLQLRETFMIPIVFHNLGYDSHFLIKHLNTDIEGNFQILPLNKERYISFTKFVQGTKCSLRFIDSYRFMSESIDKLASYLTTSQNKILKSFFPNEIQFNLLTRKGVFSYEYLDSWEKLKDENLPPKNAFYSTLTKTHISDDDYNHACNIWTEFHNNTLKDFSEIYLTTDVLLLGDIVENFRETSLKTYGLDPLHYYTAPGLSFDACLKITGVEIELLDDIDKVMFIERGLRGGISQVSNRYGKANNKYMSKDYNEQDRDSYLIYWDFVNLYGTIMCFSLPYGGFEWIDPNVMSDITTVDKNSDIGYILECDIIYSKELFNIHKDLPLCPEHLIPPKSKSKVTKLLTTLFDKKHYIIHYRALQQAVTLGLKLDKIYRVLKFNQAPWVKKYVDLNTELRKKSKNEFESNNYKMMTNSFFDLSKVWLYDFHYNYTKNKFGDNAKLLYCDTDSLIYHIFDENVYEHMRADINKFDTSNFSVNNAYNMPLCNKKVLGLMKDENGGRIMTEFVGLRSKMYALKVLNEKEEYSIKKAKGIKKSELKSITFKDYSDCLFHHTVTNATQNLIISKKHEVYTIQQNKVALRPTDDKRIVNYFETDTLPWGWEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L165</accession>
    <name>A0ABM5L165_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516176.1">
        <property type="nucleotide sequence ID" value="XM_050660219.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660219.1">
        <property type="protein sequence ID" value="XP_050516176.1"/>
        <property type="gene ID" value="LOC126891040"/>
    </dbReference>
    <dbReference type="GeneID" id="126891040"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="205" mass="23720" checksum="6EE434722C67ADA1" modified="2025-10-08" version="1">MEQHEELRRGQFTATFTYKKAQQLWEEITTNLNSVPNGQAKDWKKWRKTWQDMKKNATAKNAAIKRHRNMTGGGPTCSSSLSDQETWVLSMIGPMQTDEIGVEETPLEFSFVEQSLPSTETPLEDVIYDIAEMDSEKAHQEHNYTLEYPIQKKGKDRPQPPRKISKTARLQTSLALSQKHLAFMKEKNDIEAAYYRNKHFIDGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1M8</accession>
    <name>A0ABM5L1M8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Matrix metalloproteinase-2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516346.1">
        <property type="nucleotide sequence ID" value="XM_050660389.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660389.1">
        <property type="protein sequence ID" value="XP_050516346.1"/>
        <property type="gene ID" value="LOC126891207"/>
    </dbReference>
    <dbReference type="GeneID" id="126891207"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32924" checksum="1AD09DF5A489DBF9" modified="2025-10-08" version="1">MYPFYETFPSHITDDDKRGLEKLYGPKSKSASIPTRPGVTRSSVTTLKTTTTERSWSTTTTAARTNKSKQNIITNVCELEYPDLIFLAYAPSFPTYRMYIVSKDLVWKYDLNNEKIPTNAEQFIRYFPRGITNVTHVFQSTNGDLIGVSRNRIYAAAFPSLRIHTDNMVPEVNNARSINGLFQTNSGKKFVCFDGSFIEFNDKDIISRGRISDVFPGIPNDITSAFNYIDGHIYFLKQNIYYKFNEFTRSVVEKCTFNWNMLGFPCPDNGLIKQLKSLLSKVNLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1R9</accession>
    <name>A0ABM5L1R9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516383.1">
        <property type="nucleotide sequence ID" value="XM_050660426.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660426.1">
        <property type="protein sequence ID" value="XP_050516383.1"/>
        <property type="gene ID" value="LOC126891245"/>
    </dbReference>
    <dbReference type="GeneID" id="126891245"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="271"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="42020" checksum="972132016739CB2A" modified="2025-10-08" version="1">MGVIKEVCAFFHKSAKRTEVLKLTITECCPEQKKKKLISLCETRWVERHDSVLLFKELLEPVSISLLKIEEESSDSAPKAHALGSSITQFQFLVNTFVLSHMLSKTHNLSENLQKKNLDLTQAVKNVSNVLDLLSKERENADNNFKVLYSQIQERADKLKIKEEVPRICRLQTARNNVPYSTQEEYYRRTVYLPYLDDFCNSLKERFESHKETVASLQNILPEFFIKTDFCALEPAFNSYEEDLSHKEVVESEFMLWKERWSQEKYENLPKSAVSSLEKCDQDFFPNIYVLLKLLAVLPVSVATVERSFSSLRRLKTYLRNSTSENRLNGLALLSIHRDFAISNEEVLDKFASVPRNLDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1S6</accession>
    <name>A0ABM5L1S6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516392.1">
        <property type="nucleotide sequence ID" value="XM_050660435.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660435.1">
        <property type="protein sequence ID" value="XP_050516392.1"/>
        <property type="gene ID" value="LOC126891254"/>
    </dbReference>
    <dbReference type="GeneID" id="126891254"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="485" mass="55781" checksum="5FEF12139528502D" modified="2025-10-08" version="1">MSTKRSAVWDYFTQNSRGTSKVKCNLCFSQLACKNGSTPNMTRHLKLKHPTINIKDRRKTFNIEEQEVELDADDINTPGTSTQRLNVIDKTNTPGTSTQGLNVIDDLNTPGTSTQRLNFDEINVPGSSTSDLTSTSELTTTRNVSKTKQLAISGFIKKPIGLSRRHALDRQLLKFIVTDYQPFNIVESRNFKKFVRMLNLNYELPSRKVQSSLPTIADTVDKVKSVVEFFKRSSSATEKLKLSQKRMGCKVLKLKQDCPTRWNSTYEMLSRFHQNKESLHDSVSNLVDKLYEEVTSRFKRKYRNIDLIWEAKFLDPRFKQHGFHDDDSFKRIKEIIINKCCQIKEGDKVTKPTDDSLAIPTSSTSSKRSRFGDMWSEFDSTVDTILKKSANSRAAAIIEVDKYLHMPLISRKDDPLLWWKGNKSLFPSLFELMQRRLCIPATSVPSERIFSKTGQIITERRNRLSVEKSTKIIFLNSYFNNYDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L240</accession>
    <name>A0ABM5L240_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516500.1">
        <property type="nucleotide sequence ID" value="XM_050660543.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660543.1">
        <property type="protein sequence ID" value="XP_050516500.1"/>
        <property type="gene ID" value="LOC126891368"/>
    </dbReference>
    <dbReference type="GeneID" id="126891368"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17538" checksum="7A553B9823AB2F85" modified="2025-10-08" version="1">MLLAIAFIPVNNIIECFENLKDDAPLLVLPLFVYFREQWLETIDPTLWNMYGIRRRTNNDVEGWHNRFSRLIGKYHPNIYQFVEKLLAEQATTTLQQIRGGQNVGNNNKIYLQINNRITRLQEQFDDGDINVYEYLSKVSYNISNPIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2B5</accession>
    <name>A0ABM5L2B5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516578.1">
        <property type="nucleotide sequence ID" value="XM_050660621.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660621.1">
        <property type="protein sequence ID" value="XP_050516578.1"/>
        <property type="gene ID" value="LOC126891446"/>
    </dbReference>
    <dbReference type="GeneID" id="126891446"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="72120" checksum="608FD7AFCE80A6B8" modified="2025-10-08" version="1">MKLRFVDSFRFLASSLDKLSETLKSDQCKEVRKHFPNEKEFRLIRRKGVFPYTYVESFEKLNETWLPSKECFYDNLKGEPISDEDYRRASEVWTIFKCTTLGSYSDVYLKSDVLLLADIFENFRKVCLNQYNLDPAHYLTAPSLSWDAMLRYTKIELELLTDIDMVHFFKKAIRGGVSQCSKRKVVANNPFVANYDPLQPNAYIMYLDATNLYGAAMSNYLPTGGFKWLENCDNFDCCAIADDSFKGYVLEVDLDYPPNLHNIHNDLPFCPEPIKTSNSQYTKLMPNLYDKKKYIIHYRNLKQCLKNGLQLVKIHRVLEFFQSPWLKTYIDLNTNLRNSSKTEFERDLFKLLVNSIFGKTMENVDKRQDIRLLSHWENMKQLRGVKSYIDKPNFKTCSIFEENLVAVHMERLRVVYDKPLYVGFCILDLSKTVIYQFFYDYIKPMYKDDVTLCYTDTDSLILEINTDNVYNDIKNNISYFDTSNYPIDNIHGIPKTQSVIGKMKDEFKGVPVESFIGTGAKAYCVKLSNSNLLKKAKGISKNVIKHQLQLSDYIQVIKDKKSIHRKMYVFSSHSHTIYTELKNKISLSSSDDKRVILPDNVHTLALGHFLTRRNLQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2Z4</accession>
    <name>A0ABM5L2Z4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516816.1">
        <property type="nucleotide sequence ID" value="XM_050660859.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660859.1">
        <property type="protein sequence ID" value="XP_050516816.1"/>
        <property type="gene ID" value="LOC126891636"/>
    </dbReference>
    <dbReference type="GeneID" id="126891636"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="14">
        <location>
            <begin position="134"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="297" mass="33738" checksum="506916C3DE612C43" modified="2025-10-08" version="1">MSVEEDVMRIQKKLNKMTSEDGTGQEQALDLLKELQTLDVNLEVLTKTRIGMTVNALRKSSKDDEVISLSKTLIKNWKKFISGTNSNEKSSSSSSNKPKKEKEEKPSREEKDRDKDKGNLPKQFPASSNTTDSVRLKCREMLTAAIRTDSQADDFEGCASAEELAEELEEAIFLEFKNTDMRYKNRVRSRISNLKDPKNPTLRTNYRIGVITAGRLAVMTAEEMANDEVKKLREKFTKEAINDAQLATAQGTKTDMLKCGKCKKRNCTYNQLQTRSSDEPMTTFVLCNECGNRWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L319</accession>
    <name>A0ABM5L319_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050516841.1">
        <property type="nucleotide sequence ID" value="XM_050660884.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660884.1">
        <property type="protein sequence ID" value="XP_050516841.1"/>
        <property type="gene ID" value="LOC114324996"/>
    </dbReference>
    <dbReference type="GeneID" id="114324996"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF11">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="420" mass="48178" checksum="1413B9C1ACD3B312" modified="2025-10-08" version="1">MGRHNDSTKSVCETCGKKLYSKVTLQEHIVAVHQGLKPHKCDICELSFANRLTLRQHKRTHTGEKPYTCTYCPRAFTQSHSLKIHLRTHTGEKPEICNICQSGFTTKTILRTHMKNKHKVDSKVKVELLEDDITNLQCCDTCGKIFPDKRKLKKHQISHSTLRPYSCSICKKAFRRKHEVSTHMNVHNGLSFECDICSKVLKSKGSLIIHKKRHLKLFTAKCEVCDQGFVTNQEYLNHVGSKHGNANHVCNVCGRSCYDKATLQGHMQRHATGYSNNSDIKCDICNKTFLQERYLKHHYQRVHKNGGLRFVCDLCGKKVNSKRSLRDHLLIHQGLKPIECKECGRGFALRSTLKLHMRVHTGDRPYECKECGKCFTQKTPLTVHMRYHTGERPYRCTICDTGFVSKGALNIHQKNKHSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L4A8</accession>
    <name>A0ABM5L4A8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517281.1">
        <property type="nucleotide sequence ID" value="XM_050661324.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661324.1">
        <property type="protein sequence ID" value="XP_050517281.1"/>
        <property type="gene ID" value="LOC126891964"/>
    </dbReference>
    <dbReference type="GeneID" id="126891964"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="176" mass="20439" checksum="C49362B464FB8EA2" modified="2025-10-08" version="1">MQGKLKTKLKVIHTIRPAVTLFSKSRVKGKREPIAQRWSRRIRSLPPIPISMLSPGRKISKKVYSFPIKEEKEVAEKKIKTSLIVPIKKEKGSQKNNTSYHQKEEIVRIVPVIVYVKHNKTKLKSLADDLEIKINTKRVSAELNTTLSEKLKQECTNLEKKWSKRLKQFPTIWTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L500</accession>
    <name>A0ABM5L500_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517512.1">
        <property type="nucleotide sequence ID" value="XM_050661555.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661555.1">
        <property type="protein sequence ID" value="XP_050517512.1"/>
        <property type="gene ID" value="LOC126892107"/>
    </dbReference>
    <dbReference type="GeneID" id="126892107"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="172" mass="20110" checksum="5FAA5DB8B70500B1" modified="2025-10-08" version="1">MEQPNKKERKTESDDEFRHLNQDQDKERKEQTTENKETKDQREERAEGFEEKDNVQEKEDLELEQETGSVLMDILFGSEEFQSSKKRKAGSPETIGRYKRDKRDDQEEPEETEGERDLRKLREVLEILTIKGPVNCENKYRVVNILAELYKGNKSSLYLGSQTSAIDSDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5M7</accession>
    <name>A0ABM5L5M7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517742.1">
        <property type="nucleotide sequence ID" value="XM_050661785.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661785.1">
        <property type="protein sequence ID" value="XP_050517742.1"/>
        <property type="gene ID" value="LOC126892284"/>
    </dbReference>
    <dbReference type="GeneID" id="126892284"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="183"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="430" mass="49518" checksum="55BEFD146A4BCBF4" modified="2025-10-08" version="1">MFFSQEDFFILSCGWLILKSLEKKRRRKRKHRYWVRSLLSRRVNDGAAQFMNDIQNDDFGLHGELRSSFHNFVRMSSSDFEELMTLIGGKIAKLNTNFRDSISIKDRLAVTLRFLASGDSYQSLMYLCKISVPSISRIIPEVCDALNEVLNDYIKVPTNSAQWQKLANDYNTRWNFPMCVGSMDGKHVVMQSPKYSGSEFFNYKGTFSIVLFAVVDANYNFTYVYIGCQGRISDGGVFKNTGFAKSLSKEMLNLPENASLPEREKRVPYVFVADDAFPLSPNILKPFSGHQDRGSMQRIFNYRLSRARRVVENVFGILASVFRIFRKPILLEPPKVEKIVQTCVLLHNYLRRNTESKNTYTPPGSFDVEDIDSGTIRNGSWRNESQPTASMLPLKPVARKSLQEAQNIRNEYCEYFISDQGQVPWQLKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6M4</accession>
    <name>A0ABM5L6M4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518082.1">
        <property type="nucleotide sequence ID" value="XM_050662125.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662125.1">
        <property type="protein sequence ID" value="XP_050518082.1"/>
        <property type="gene ID" value="LOC126892560"/>
    </dbReference>
    <dbReference type="GeneID" id="126892560"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="711" mass="81152" checksum="55040DD28783DB4F" modified="2025-10-08" version="1">MVTRRQLFDVLYEKDKLQRSSRTEYLFKYLVRHYKIENDADAMLKMRIFTSKFCNVVYAKLDQCGRKTDRFVKNNTAWLSVCVFEETGLEIDPNAEPQPGTSSGGRRGRPSKEFSASSVRSKRRKTSKLSSTFETEELTLAARRKLKTEGKDDAAKLVSEALLTPTRAGKIRTAWQKTQKSKKIIPLTPDEALSVMIESKDTKHSYLVHRRIAKEHFADIYPSYHKLREAKLRCYPRKEGQTVSESCAEILLQDLLDHTVKRIVELQKPVLRSLSTELLKNLKLLLKWGCDGSTGHSQYKQLFSDNSFGDGDLFLTSIVPLQLYAEQPGQDKIIVWQNPRPSSTRFCRPIRFQFKKETKELTVQETSYIENQISELQPTIGMLDSEEIAVSHVCVMTMIDGKVCNAITETASSQTCYICKATPKQMNDIEKLLKREVVQENLKFGLSTLHAWIRFFECLLHISYRLEVKVWQIRGSNNRAVFENKKRTIQQIFRDRTGLLVDIPKSGGSGTTNDGNTARRFFADPSLSSEITGIDKDVIMRFGIILRTLSCGYAIDVRAFEEYCLETAKLYVAKYSWYYMPSSVHKILLHGAIVIKEAILPIGQLSEEAQESRNKDLKSFREKHTRKISRISGNQDLLNRLLITSDPVISSLRQYPLRKSSNISSEVVSLLKAPSLESMEADSLKALQLNMESRQVSSSDEEDDSASDVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L7R2</accession>
    <name>A0ABM5L7R2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050518475.1">
        <property type="nucleotide sequence ID" value="XM_050662518.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050518476.1">
        <property type="nucleotide sequence ID" value="XM_050662519.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662518.1">
        <property type="protein sequence ID" value="XP_050518475.1"/>
        <property type="gene ID" value="LOC126892791"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662519.1">
        <property type="protein sequence ID" value="XP_050518476.1"/>
        <property type="gene ID" value="LOC126892791"/>
    </dbReference>
    <dbReference type="GeneID" id="126892791"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="316" mass="37050" checksum="276BC731C18D6C9C" modified="2025-10-08" version="1">MADTSNIADIEDDPFAEVNMTVYYEQMKQTWDILNYTSYFTDTIKIILSILSIAADICIITIIIKNPKLKTKTNIYILHHSIWHIVSVTVFSLFFALSDLVEWFNTFPMVVYSTFWKMHVASVTLVFLFGLCLAFDWFLNIHSPHFVKFSALFNKYAIYLIYIVAALFDTIEYFVHMFILSGLYIFVVLSLSLFNFLDYRSNKKEVNLKNYGLASANIIIYFWFPFFLYDQLLEWSYGSFTWHTIVLYTMFLSEWFSLSVSLALIITLIRMDIDIKVAMLKIFNRRSRRYQDVVETLEEAENEDVAITIATDSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L8Z8</accession>
    <name>A0ABM5L8Z8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Agrin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050518916.1">
        <property type="nucleotide sequence ID" value="XM_050662959.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662959.1">
        <property type="protein sequence ID" value="XP_050518916.1"/>
        <property type="gene ID" value="LOC114330735"/>
    </dbReference>
    <dbReference type="GeneID" id="114330735"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF78">
        <property type="entry name" value="AGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="50"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="464"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="599"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="9">
        <location>
            <begin position="652"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="722"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="919"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="964"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1401"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="7">
        <location>
            <begin position="1491"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1429"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1677" mass="186396" checksum="B968FCF8265B0BAA" modified="2025-10-08" version="1">MWPIHFHLFSLTVAYNYSQVQLYIYENKVQLAYPCAGVQCTEPEVCQLDEHRNPVCRCGDPCPLEFTPVCGSDGKTYSNECTLRQEACRARKPMNIIYRGKCSSGINPCISVHCVAGEECIINKFGIAHCQCADTCEPVMRPVCSRDGRTFPSECELKRTACLTRTNMKVAYTGICGENGPCSEHECQFGGTCIERAGTAHCECPECPAEFEPICGSDGISYSNECKLRLEACKHRRNITVLYRGPCNGCESKKCDFYSECENDGTSEGHCICPQSCTDSKLNNGTVCGTDGITYPSECELRQASCKTKQYIILAYKGNCDLCQGVQCKFGGRCEAGECVCPKNCEEAGEEPVCASDMMTYPNECELLKARCAKGSKTAPISVVFYGDCREKFPSAGSLSTTFPNLTEQRTNQKTGQDMEVVVPQLTGNSILDGITTEKEACKDILCDFEATCEVGPDNFPRCTCQFNCANAYSSPVCASDLRIYSSLCAMKMEACQRQEELRLRPLDLCQGMEVKPCKGEKPLTDPVTERELDCGNGPFRQDCPAGSYCHQTAKFSKCCRKNEAVVEKKDCEESWFGCCPDGKTPAQGQNFGGCPSICECNKLGSYSDICDPETKQCKCKPGVGGTKCDRCEPGFWGLPKISAGYQGCIPCGCSTFGSVRDDCEQMTGRCVCKPGVQGQKCTICTNHNKYLGPNGCVSASMANPSTCAERNCYFGAVCIEKDRKALCECHLNCTNSRDSQVVCGSDGKTYSSSCDLRRSACKLQRDIVLQGFGSCKDDIQSTDWPYSGVNPKQFTQPDEISSPLSKSTRHLLVPDPRYYYERSSNVHPVSFPGTDFGGNEPNTNMLYRNRGNEFAPAYRPTPATVRVLTALLGDICSENSDCLIMNSHCVKGACICVSNYIESSDRQDCLANSADMDEFPACSSSPCNHGGTCIDLPASTYACVCTANFTGLLCELEITLTQYETPAFHGKSYARLRSLKAYHKLSIEVEFQSYTEDGVILYNQQKADGLGDFVSLAIINGFVEFKYNLGNGAVLIRSVDKIKKGEDHKVVIRRYHRDGVLKLDESEEITGQSSGSLKALDLLEDAFIGYVPTNYTRVYDNIGTSKGFQGCIKKLRIGRQEVEIHMRQEEWVLEVSGIYDCSDHACKVSPCQNKGKCLESDQLFQCDCPPKFTGEYCEKFEGPCIGEQCMFATDCQNKKLGIPCQEDFKNLHNLIPEFNGNSYIQFPKLQGIKKRFTMEIIFKTTAANGLIIYNGQMKNGKGDFISLNIARGYLQFRFNLGSGIANLTSSNPVTQNKWHRVVISREGREGRLQVDNSTEIRGYSGTPLTELNLETPLYIGSINNWKQIHRLSGASKGFKGIIQKVTFNHIPLHISSPLPDCTPAIPQNDSQCVSNIAYYEGTPCPPGNNPCLNNGICVPELDNFTCKCNGKYKGRYCETIDEENISIKLNGATYLQYTNRGYRSENLTNVTDNDEEIQNKTIEDEEIEHDNDFLDEHTFDYDVEDLEFSYDFRRKPERGNRYELKIRTFRSEGLILWRSKNRNQLQNYLSIAIVDGYPELSFNLGHNEPFWAIRSRTKVDDGEWHLIQVRRRKRMGFISVDGHNTNKGVAKTGAIALRTNSKLWIGGTSTLPLGLPSSYYKGFEGCIQKILIHGKPIDLLANNDISKINFCHDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAN6</accession>
    <name>A0ABM5LAN6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519499.1">
        <property type="nucleotide sequence ID" value="XM_050663542.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663542.1">
        <property type="protein sequence ID" value="XP_050519499.1"/>
        <property type="gene ID" value="LOC126893403"/>
    </dbReference>
    <dbReference type="GeneID" id="126893403"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="556" mass="66207" checksum="DB61783965DB75CB" modified="2025-10-08" version="1">MVNTRSSKVEKEMDTSGPPAWFLKMKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKEEDKKLRKEEEERRRQAEVEIMNSLSQIHEHFQLEVSRITNKIDILEEKQNCLDNKIEQQQNYLENKIDQQQNHLENKIEQQQNDLKQQQNDLKYSLEKQIVELANKINTQASLSHIVSVTNIESEQTALSSSIVDPGIIRSSKILKPPTFDGQTAWETYRFQFEAAAKANGWTEREMAASLVVSLRGQAATVLQFLPRDSPSYDSLVQALETRYGQQHLKQVFQSQLKVRYQKHNESLQEFEADIKRLLHLAYPQAPKDFLEQIGIQAFIDGLHDIEMQQALRLQHHKTLNGALVSAQEFEAAKSISRSRPRLKEIRFREDEQVPTTDNQQPILSQMLNILQNLQQNQQKAQNQNRRCFNCGRIGHLQVNCRSGSQARKEEYNNDVRRSPRSTSRSPSYSPTRNISRDRYVRSRSPTTDHRYSNNSQGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LB49</accession>
    <name>A0ABM5LB49_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519665.1">
        <property type="nucleotide sequence ID" value="XM_050663708.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519666.1">
        <property type="nucleotide sequence ID" value="XM_050663709.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519667.1">
        <property type="nucleotide sequence ID" value="XM_050663710.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663708.1">
        <property type="protein sequence ID" value="XP_050519665.1"/>
        <property type="gene ID" value="LOC126893468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663709.1">
        <property type="protein sequence ID" value="XP_050519666.1"/>
        <property type="gene ID" value="LOC126893468"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663710.1">
        <property type="protein sequence ID" value="XP_050519667.1"/>
        <property type="gene ID" value="LOC126893468"/>
    </dbReference>
    <dbReference type="GeneID" id="126893468"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02983">
        <property type="entry name" value="P5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045028568" description="Thioredoxin domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="144"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="426" mass="46762" checksum="20045A86097FD2E0" modified="2025-10-08" version="1">MIQILFLGLFFQSSLALYPSSGSVVELTPSNFDKLVIKGDEVWVVEFFAPWCGHCKNLVPEYTKAANALKGIVKVGAVDVDQHKEIGGQYGIRGFPTIKIFGADKRKPEDFNGGRTAKDIVEGALKAAKAKAKANLGLGGGSQSDDSDNSHVVELTDSNFEKLVLKSDDMWLVEFFAPWCGHCKNLAPHWAKAAAELKGKVKLGALDATVHQARASLYGVQGYPTIKFFGPGAKDSPTDYDGGRTSSDIVTWALDKLEENIPAPEVTQILDDKSFKKLCEDKPLCVVAVLPHILDCQSECRNNYIKMLAGIGETFKKKMWGWVWSEAGTQLDLENSLDIGGFGYPAMAVINSKKMKYSILRGSFSKDGIYEFLRNLSYGKGNTAPVKGQQLPKINKIEPWDGKDGVLPEEEDIDLSDVDLDEKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EZT6</accession>
    <name>A0A6P7EZT6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Zinc finger CCCH domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC114324456</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10 11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128117.1">
        <property type="nucleotide sequence ID" value="XM_028272316.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128122.1">
        <property type="nucleotide sequence ID" value="XM_028272321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502226.1">
        <property type="nucleotide sequence ID" value="XM_050646269.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050502227.1">
        <property type="nucleotide sequence ID" value="XM_050646270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7EZT6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028272316.2">
        <property type="protein sequence ID" value="XP_028128117.1"/>
        <property type="gene ID" value="LOC114324456"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272321.2">
        <property type="protein sequence ID" value="XP_028128122.1"/>
        <property type="gene ID" value="LOC114324456"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646269.1">
        <property type="protein sequence ID" value="XP_050502226.1"/>
        <property type="gene ID" value="LOC114324456"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646270.1">
        <property type="protein sequence ID" value="XP_050502227.1"/>
        <property type="gene ID" value="LOC114324456"/>
    </dbReference>
    <dbReference type="GeneID" id="114324456"/>
    <dbReference type="KEGG" id="dvv:114324456"/>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028128117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028128122.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="60921" checksum="1350CDEF49230BF7" modified="2020-12-02" version="1">MSDTSEDTIQSDRTSEKEESVCRDFARGLCDRKFCKYKHENETKLLNFCHDFQNYICPRPFCKFIHCSTDEVDQYKRTGQMSAQILAEATRKNQMPGSPPVCNQFKRGQCRRPHCKYRHITKDQEEAEIAGLVNGEQKKVQSIVITNNMSEPQLVTLESLRGVFRRNGVTFDDYKDEGLPVVKRRFITTQEPEILACDIVETGTARPLFKGYFAGNPPPPMLTRADARTLMLEEENNILHKEIAQLKKQVSDLTATNEFLLDQNAQLRVSGKRNGTVNVPAVSLTNTPTPQVNRTVIASVATVPVSLATVSTCNPVSGNHSVSIAGCPAVSMAPAQILANSQQILVTTNPTTQLAIANSSQAQLAIAQQNLATNLAAAQQAAQPQLTSQAQQLALATTTQQLTSQAQHMANQQLALASAAGSQLTTQTQQIALANNAQAQQLALAAGTNQQLTSQAQQLALASTNQQLTSQAQQLALASTNQQLNSQAQQLTVTNVPPQLALASTNQQLLAQQNLASEIHRNTQINAISTSQAIAMSNAASQPMVSYPIMTQSINHALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4A6</accession>
    <name>A0A6P7F4A6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptic vesicle glycoprotein 2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114325775</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129707.1">
        <property type="nucleotide sequence ID" value="XM_028273906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4A6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273906.2">
        <property type="protein sequence ID" value="XP_028129707.1"/>
        <property type="gene ID" value="LOC114325775"/>
    </dbReference>
    <dbReference type="GeneID" id="114325775"/>
    <dbReference type="KEGG" id="dvv:114325775"/>
    <dbReference type="InParanoid" id="A0A6P7F4A6"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF38">
        <property type="entry name" value="SYNAPTIC VESICLE 2-RELATED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="31"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028129707.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58497" checksum="C18474011E7B3D77" modified="2020-12-02" version="1">MMPKLCRSNSESVTFDEAIILTGYGRFHYEAIAVCSLSIIIVGFQNGISSYIFPPAQCELNLTSLELGFLNVSFLVGGTVSCFLWGLIADNHGRKKVLIFAHICNVIVTMVSAVNPYTATLVSCRFINGFLMGAPGSLMYTYIAEFQPSTHRFRTVCILGLFFIGSWLFLPVIAYLILPVNINYNFKNIFIISPWRVFLLLIAIPEILVCLWLTRLPESPKFYIARGNHKKTLKILKNIYSANSGKSPELFPVKTIICEVYNNVQNSEVMVSGKTARILKEVTNQIRKLFQKPFNTKIFVISAIMFSNMFGLFGLGLWLPELFIKFEKYHLLHPNSSVTIEELSSLPKDRENSCQPSFDQSVIISTVATGSTALIFNGISCLISTRVSSRNITLVLTFLGGISAACIYFLTTSLQNLIVSCIFQATMLTANMSITSIAVELFPTSIGGMAVCFVICAGRIGAAISNVVFAFLMDDYCQLAIFAVASVQIIGGILCFLVPAQKKCAETVKSFEETKLNNFEIAAINNQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6K9</accession>
    <name>A0A6P7F6K9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC114327072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114327072</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131384.1">
        <property type="nucleotide sequence ID" value="XM_028275583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6K9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275583.2">
        <property type="protein sequence ID" value="XP_028131384.1"/>
        <property type="gene ID" value="LOC114327073"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654253.1">
        <property type="protein sequence ID" value="XP_050510210.1"/>
        <property type="gene ID" value="LOC114327073"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7F6K9"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027746724" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028131384.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19476" checksum="64A77A950671428B" modified="2020-12-02" version="1">MKYFVLLVSIVAITASDLQGTAVDQCLCRDELTQIYNQLVEANVELKEANDEMIQLDSHMEYMDNRVEGQNENLEELESALTMLRYIQLQTLQELSSQDQILNCIVVTVQNIDVQVKNETTHVNQQTIDIGALQQLTNEIQQCNNVNSCVAPTTTPAPTTTTVPTITTEDLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F8E6</accession>
    <name>A0A6P7F8E6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114327603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114327603</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028132074.1">
        <property type="nucleotide sequence ID" value="XM_028276273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F8E6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028276273.2">
        <property type="protein sequence ID" value="XP_028132074.1"/>
        <property type="gene ID" value="LOC114327603"/>
    </dbReference>
    <dbReference type="GeneID" id="114327603"/>
    <dbReference type="KEGG" id="dvv:114327603"/>
    <dbReference type="InParanoid" id="A0A6P7F8E6"/>
    <dbReference type="OrthoDB" id="7419171at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF41">
        <property type="entry name" value="RE70318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027710316" evidence="4">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028132074.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28539" checksum="8C8C49E2A987593D" modified="2020-12-02" version="1">MIMKIIYVILGIIFLGCVECKKLPSFVEQCYYDQSMEECIIRNINKLKPQFKNGIPELGIPSLNPLKAPGVTLVSDRNMKLVLKNVNIYNIDQFELKDFKHYRHNLTDYFEYYLPKIELRSDYILKGQFLLFNLDTSGKSFITLDGVHAKHFVKIQRVMKHGELYLKINKTETTIEVGDIHIQFDDLFKNNPELSDSANKLVSENAKSLLPDMEMVPRLFAEIVGSLLEKVYNKFSLNELLPTRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F960</accession>
    <name>A0A6P7F960_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114327002</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="RefSeq" id="XP_028131302.1">
        <property type="nucleotide sequence ID" value="XM_028275501.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050510825.1">
        <property type="nucleotide sequence ID" value="XM_050654868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F960"/>
    <dbReference type="EnsemblMetazoa" id="XM_050654868.1">
        <property type="protein sequence ID" value="XP_050510825.1"/>
        <property type="gene ID" value="LOC114327002"/>
    </dbReference>
    <dbReference type="GeneID" id="114327002"/>
    <dbReference type="KEGG" id="dvv:114327002"/>
    <dbReference type="InParanoid" id="A0A6P7F960"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20902">
        <property type="entry name" value="CC_DOT1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.60:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-79 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="14">
        <location>
            <begin position="12"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="333"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="572"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028131302.1"/>
        </source>
    </evidence>
    <sequence length="912" mass="104424" checksum="94D637679CA609ED" modified="2020-12-02" version="1">MELKLHSPVGAEPVCYTWPLIYGRGNDKHDRATEIVDTIRWVCEDLPVLKLPLENNILCNYDTKSYESMKSLCDRYNKAIDSVVALEKGTSLPSHRTAKSPSRGLLKHILLQTYNSSVTAPERLNQYEPFSPEVYGETSYDLVCQMIDHIKISSDDVFIDLGSGVGQVVLQMAAATSCKLCIGIECADVPSLYAESMSKNFRTWMRWYGKKYGEYKLIKGDFLAEEYRENISQSSIVFVNNFAFGPALDHQLKERFADLRDGVKIVSSKNFCALNFRISDRNLSDIGTIMHVNEMPPLKGSVSWTGRPFSYFLHTIDRTKLESYFQKLKQASLRNNEEDNNSNSTTSSRGTRARTYFLRNSSDYTTDSDSTDWSSRFSQKPKRSRTNYKSIRKKRPESRAPKNKHQLRKPQYKISPNTKVEKIEEKHKIKEEPINDLDFLHNETVSIVSKFDDSPAPGCFNHKLTSRNTGLIVHEEISIPDQQTPYELQVLLVNFKVQYMDMINQMKSKTYKNFILSQIEGERKKKKHLENRATQLEKQVTVLKNEGVKLINVRKKEMGLNGNTPAEISAEAKEVVKKHKKLQSKAKRLENQVAKLESKQKELMRQRQAELGVKLLSDVDTSSEVFKDNVLREICAAFERRKKLQSNVVQLEKDVFNLNLNETKAQAQPCSNYVNHSKIYTEISSTSKHDQNSANFVQKRRKNEIISTYDMNTTVPDIKNNSRRYSKRNDKNRVTYNSISASSSGQNRQICHNNVKIETDVNVSVIKQNLPITNFDISLESIITSVLNEDIKDTPRNTPVLAPGYQTQMPHSKLQTIKYQNNTTNHNNVISSRTRQQATRSRTNTKLSPPVNRANFKVPTADHASLLSTAQDSETPQQQVYMSRPPPVERLEGLAYMYAQSKFATQLQPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAF0</accession>
    <name>A0A6P7FAF0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Autophagy-related protein 16-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114326330</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130460.1">
        <property type="nucleotide sequence ID" value="XM_028274659.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028130461.1">
        <property type="nucleotide sequence ID" value="XM_028274660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274659.2">
        <property type="protein sequence ID" value="XP_028130460.1"/>
        <property type="gene ID" value="LOC114326330"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274660.2">
        <property type="protein sequence ID" value="XP_028130461.1"/>
        <property type="gene ID" value="LOC114326330"/>
    </dbReference>
    <dbReference type="GeneID" id="114326330"/>
    <dbReference type="KEGG" id="dvv:114326330"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028130460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028130461.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61439" checksum="0B04C665AA52A350" modified="2020-12-02" version="1">MTAYAETNSWRNSILNQLQERNKRETDLFQELVEEHTKIFENYNTLYTENIQLSIQVEKLKGRGSLGSNSSSLGDIKLQERIQHLEQKLLVQAEELTELHRRKGENAQQIIDLNALVQEKEKIIASKNVILAENAAKMVSLQAEISMLDKSKNELQYLWDTLRDEHQALQMLFTSLEDKLRKAQDENRQLVERLIKYKAKDADRMNEENDNFLKKRYAKMQKEIEEACKDTRGSPEELTEGYGPLCTSNLPASLNVKFDAHEGEVSAVKWSPLEKLLATGGADRKLKLWEISKGCYDSKGTLVGSNAGVMAIDFDSSGSLILGASNDYATRVWTIADQRLRHTLTGHSGKVMAAKFLGEASKVVTGSHDRTLKIWDLRSRACIETKFAGSSCNDLVTVDSAGSIIISGHFDKSIRFWDSRSESSANNVVLNGKVTSLDLTRDAKYLVCCVRDDTLKLLDLRMNQVVTLFSCDGFKVGCDYSRATFSPDGQYVAVGSADGSVYIWGVNSAKVETILKEHGAAVTATSWNPFGNFLTSVDRSKKAIVWSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FAZ5</accession>
    <name>A0A6P7FAZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Testis-specific serine/threonine-protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114326526</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130723.1">
        <property type="nucleotide sequence ID" value="XM_028274922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FAZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274922.1">
        <property type="protein sequence ID" value="XP_028130723.1"/>
        <property type="gene ID" value="LOC114326526"/>
    </dbReference>
    <dbReference type="GeneID" id="114326526"/>
    <dbReference type="KEGG" id="dvv:114326526"/>
    <dbReference type="InParanoid" id="A0A6P7FAZ5"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14080">
        <property type="entry name" value="STKc_TSSK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000943">
        <property type="entry name" value="testis-specific serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028130723.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="42043" checksum="76BF981B6ADC33A5" modified="2020-12-02" version="1">MAPGLVLRESEELTLSTRGYRLLQKLGEGSYAQVFLAEFVNQGKSTQSTKSTDNSDKPSRVLACKIVDVSKAPPDFVKKFLPRELDILVRISHPHIIHIHSIFQRKTKYFIFMRHAENGDLLEYVLKKGPIPEVQSRVWFRQLTLAVQYLHDMDIAHRDLKCENCLITNNYNLKLADFGFARFVTDAHGRRLTSTTYCGSLSYAAPEVLKGMPYYPKNADIWSMGIILYIMINKAMPFDDANVKRLNEQQLNRRWKFRQKVVDQLSDQVKNLVASLLEPDITKRLRLNDILSSDWLAMDPRLKVLSQLEESALAQAQVDRKKYIDQLNKKAGRDKKSDRSEEMKILKSTDGEELAKPDDPSSAALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FE09</accession>
    <name>A0A6P7FE09_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HIG1 domain family member 1A, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114327253</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028131595.1">
        <property type="nucleotide sequence ID" value="XM_028275794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FE09"/>
    <dbReference type="FunCoup" id="A0A6P7FE09">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028275794.2">
        <property type="protein sequence ID" value="XP_028131595.1"/>
        <property type="gene ID" value="LOC114327253"/>
    </dbReference>
    <dbReference type="GeneID" id="114327253"/>
    <dbReference type="KEGG" id="dvv:114327253"/>
    <dbReference type="InParanoid" id="A0A6P7FE09"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131595.1"/>
        </source>
    </evidence>
    <sequence length="96" mass="10645" checksum="D7760AF75F67BE59" modified="2020-12-02" version="1">MSVTTMNEPPRIYYEEESQSDKLLRKSKETPVFPIAIGICAAAVGYGIYAYKNKGKMSTSVYLMHLRVGAQGAAVGSLTLGLIYTMINRHFLKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEA3</accession>
    <name>A0A6P7FEA3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">G protein-activated inward rectifier potassium channel 3 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114329438</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134344.1">
        <property type="nucleotide sequence ID" value="XM_028278543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEA3"/>
    <dbReference type="FunCoup" id="A0A6P7FEA3">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278543.2">
        <property type="protein sequence ID" value="XP_028134344.1"/>
        <property type="gene ID" value="LOC114329438"/>
    </dbReference>
    <dbReference type="GeneID" id="114329438"/>
    <dbReference type="InParanoid" id="A0A6P7FEA3"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="103"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="253"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028134344.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59151" checksum="A65DC9C938EDB9B1" modified="2020-12-02" version="1">MTNNNQAILEDVYVDGNGRNSDQFEKLLGHSQTAPTLPALLPAAQIGKKLESRRKSDNSLLGSLNKLRYSIGSKDGPIQLNNRLGRFRQSRFNARRIRKRVVFKHGDCNVVQGNVAKRRRKYLQDIFTTLVDAQWRWTLLVFAMNFFLSWLLFALVWWLIVFTHGDLSEEHLSGNDTTYIPCVTNIRGFTSCFLFSIETQHTIGYGGRTPTEECPEAIFVMCIQSITGVMIQAFMVGVVFAKLSRPKKRTQTLMFSRNAVINHRDGVPCLMFRVGDMRKSHIIEAHVRAQLIKHKVTKEGENLPFFQTELKVSSKVGGDGEEDKIFFIWPTTIVHKIDCHSPLYNMSANNLLRERFEIVVILEGVIESTGMTTQARSSYLPSEILWGHRFQSLITFKKDSGEYEVDYALFNNTVEVDTPLCSAKELDERRAMYNHDGLEVNSKYLTTGQCRMTGLFPTARSQSSDTLSSMDSLSIDDGHIEIKIPVSPIGVTVTAPEEAEEKTPLTNGSVPNGTLKNKSNILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FER3</accession>
    <name>A0A6P7FER3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Solute carrier family 35 member F5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114329363</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134231.1">
        <property type="nucleotide sequence ID" value="XM_028278430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FER3"/>
    <dbReference type="FunCoup" id="A0A6P7FER3">
        <property type="interactions" value="1419"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278430.2">
        <property type="protein sequence ID" value="XP_028134231.1"/>
        <property type="gene ID" value="LOC114329363"/>
    </dbReference>
    <dbReference type="GeneID" id="114329363"/>
    <dbReference type="KEGG" id="dvv:114329363"/>
    <dbReference type="CTD" id="80255"/>
    <dbReference type="InParanoid" id="A0A6P7FER3"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028134231.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52701" checksum="B33790A6AC963F74" modified="2020-12-02" version="1">MENDDPMLTKTQRLVLGFLVLILVDVIWVSSSELTKFIYKNETFEKPFFCTYIKTSMFTLYLLGFLFWPSWKDSCSKPSNYIYLQTEDDDDNYITDANCGSSLSNPVYVPVKTPERENWDRSSGTESDDSTVRSVRFNKLAEVRHMSETEATEALLARLSYQASVRASEMAKRAANRLPIARVAKIALIFCLLWFIANYTYQVALSETEAGIVNVLSSTSSLFTLVLASIFPSNPSDKFTLSKLVAVFLSIIGIVLVSFSDLTIESKLPFGAVLSLFSAFFYATYLVFLKRKVDHEDKIGIPLFFGFVGLFNLLLLWPLFFFLHFSKLEIFEWPTREQLLLLLLNGLLGTVISEALWLWGCFLTSSLMATVAMSLTIPMTMLADVLLKEVPYPILFYTGTLPVLVAFLAVTVLSHYENWDPVFDILQCAYQNVCKKSRFIRSRFKEAASEQTEALIGINSCEHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEV9</accession>
    <name>A0A6P7FEV9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable serine incorporator isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114327458</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028131885.1">
        <property type="nucleotide sequence ID" value="XM_028276084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEV9"/>
    <dbReference type="FunCoup" id="A0A6P7FEV9">
        <property type="interactions" value="1093"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276084.2">
        <property type="protein sequence ID" value="XP_028131885.1"/>
        <property type="gene ID" value="LOC114327458"/>
    </dbReference>
    <dbReference type="GeneID" id="114327458"/>
    <dbReference type="KEGG" id="dvv:114327458"/>
    <dbReference type="CTD" id="136028748"/>
    <dbReference type="InParanoid" id="A0A6P7FEV9"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027702461" evidence="7">
        <location>
            <begin position="17"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028131885.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="50398" checksum="4A3B9E77F679C1E4" modified="2020-12-02" version="1">MGAVLGLCSAAQLACCCSSAACSLCCSACPSCRNSTSSRIMYALMLLVATVAACITLSPGLESALQKVPFCKNSSALVPDSVVFDCKQAVGYLAVYRICFILTCFFALMSLMMIGVKTSKDARAGIQNGFWGIKYLLVIGGIIGAFFIPEGSFGSVWMVFGMIGGFLFILIQLILIIDFAHSWAEAWVGNFEETGSKGWYVALIGMTMLNYILSITGIVLLYVFYTKANDCGLNKFFISINLIICLIVSVLSILPAVQDKLPRSGLLQSSVVTVYVVYLTWSAVSNSSKECNPGMWGIFGGKSNNKTSSDFDIIGLLIWMCCVLYSSLRSASKSSKITMSESMLAKDTGAVKDYGSDNLVDNEEPYAPIAGNDGGEGGDKKVWDNEEETVAYSWSFFHVMFALATLYVMMTLTNWYNPNSNLDKLHYNPASMWVKTISSWLCLGLYGWTLVAPVILHDREFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FJJ0</accession>
    <name>A0A6P7FJJ0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Glutathione hydrolase 1 proenzyme-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC114328498</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7 8 9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133170.1">
        <property type="nucleotide sequence ID" value="XM_028277369.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133174.1">
        <property type="nucleotide sequence ID" value="XM_028277373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028133178.1">
        <property type="nucleotide sequence ID" value="XM_028277377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FJJ0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028277369.2">
        <property type="protein sequence ID" value="XP_028133170.1"/>
        <property type="gene ID" value="LOC114328498"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277373.2">
        <property type="protein sequence ID" value="XP_028133174.1"/>
        <property type="gene ID" value="LOC114328498"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277377.2">
        <property type="protein sequence ID" value="XP_028133178.1"/>
        <property type="gene ID" value="LOC114328498"/>
    </dbReference>
    <dbReference type="GeneID" id="114328498"/>
    <dbReference type="KEGG" id="dvv:114328498"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF72">
        <property type="entry name" value="GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650938" evidence="4">
        <location>
            <begin position="19"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="388"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="440"/>
            <end position="441"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028133170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028133174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133178.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="61284" checksum="1B61C9B3B529B241" modified="2020-12-02" version="1">MPVLQGLLLLLLAGSLTAMPNPLSTSGLEGAVVSNAPGCAEVGRDILKKGKNAIDAVIATAFCEGVGNPTTMGVGGGFLATYYNRAENIVYSINSREMAPSGATEDMFVSNQSLAQRGGLSVAVPGETRGYWILYNKFGGGVPWSALVEPTIKICEEGIEMNELTYNNVRDQIDVVRADPGLREIFINPATNQVYKKGETYKRVKLAQTLRVIAREGGNALHNGSLTKKFVADIKANGGIITAKDLADFKVEFLTPVNTTISGKQIYSVPLPGAGIIMTYILNILENYLPRNDHLSVKTYQRIVEALKYGYAMRSSLGDQDFVPGLDDLITKLSSKRYAADTRKKITDLKTFNEATHYGATFQSIQDHGTANLCVWGPNGDGISLTSSINYILGAGFVSESTGIILNDSMDDFSTPGLVNEYGYPPSPSNFIRPGKRPQSSMCPTIILDGRNDLFMVVGGAGGSKITSSVMQVILNRLYFNMDVESASGLQRVHHQLFPMTLDMEDEWIYENPEIVKGLQSKGHNITFSYPDGFVAVTAISLDKDSRHLVGVHDKRRRGSVAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKX6</accession>
    <name>A0A6P7FKX6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20 21 22">Nidogen-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20 21 22 23" type="primary">LOC114331339</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20 21 22">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136673.1">
        <property type="nucleotide sequence ID" value="XM_028280872.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136674.1">
        <property type="nucleotide sequence ID" value="XM_028280873.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136675.1">
        <property type="nucleotide sequence ID" value="XM_028280874.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028136676.1">
        <property type="nucleotide sequence ID" value="XM_028280875.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280872.2">
        <property type="protein sequence ID" value="XP_028136673.1"/>
        <property type="gene ID" value="LOC114331339"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280873.2">
        <property type="protein sequence ID" value="XP_028136674.1"/>
        <property type="gene ID" value="LOC114331339"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280874.2">
        <property type="protein sequence ID" value="XP_028136675.1"/>
        <property type="gene ID" value="LOC114331339"/>
    </dbReference>
    <dbReference type="GeneID" id="114331339"/>
    <dbReference type="KEGG" id="dvv:114331339"/>
    <dbReference type="OrthoDB" id="6375837at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00255">
        <property type="entry name" value="nidG2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
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        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052235">
        <property type="entry name" value="Nephronectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050:SF28">
        <property type="entry name" value="UROMODULIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044650945" evidence="14">
        <location>
            <begin position="21"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="17">
        <location>
            <begin position="95"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="16">
        <location>
            <begin position="305"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="571"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
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            <begin position="612"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="653"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="761"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="804"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="889"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="932"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="974"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1153"/>
            <end position="1198"/>
        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="771"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028136673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_028136674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_028136675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_028136676.1"/>
        </source>
    </evidence>
    <sequence length="1333" mass="147685" checksum="400056B855DBEBD2" modified="2020-12-02" version="1">MKLVLGTLLYILCLISDGLALPEGLLYLYNVPEAIPLPKGDDISSSEIRLREPIVFFGVTYESIFVNSNGLLSFQTEIPRFINIEFPLDYPIIAPFYSNVDTTSVGTVSYYETENPGLIQRATENVHDSFLNFSDYQATSLLIVTWQGVGYFNNGSDKVNTYQVVISTDGEQSYVEFLYPENGIQWIQGTGDESGLPDARAQAGIISPEGKVFSLPGSGTEQVKNLKEWTNMGLEGQFIYRIDQLEIVEPDVDFGGKSDEDDNTCTSAKTLCHIQARCIDYDEGFCCECNPKYYGNGRHCIKKDVPLRVNGKIYGKINGEKLDGLDLQSYVVMSDGRAYTAISKVPESIGFDIQSMQILGGTVGYLFAKPIRTALNGYQITGGVFNHSATVTFLNTSQTVRLKQKYLGLDVFDQLRLEADIQGDIPLLPDESRVSIDEYQEEYTRTAPGVIQMTSQRVLRVLNPKGDETVQYYTVDQNFVFDYCKFANISVGDTWKLKVGKNFISYESREQIIRFGLSNKITPLGDFDPCEEGRSQCSQNSACVVDNDSFRCVCNPGYQSFFDGNTTTCSDINECQTGQHECDYNAQCINLVGSYACQCNPGFEGSGHICDNARSCQNVTCNENAECIESNGIASCRCMAGFRGDGQYCNPIPDHSCHIANNCSPFAYCAINRETNQYSCACLPGYLGDGYRCLEIETTTPEPTTTETVEYTEPGNQEILQTCNSDGCYCPSGYVIETGTPYCVLETTTLPTTVPHPTERLPGSCSVVNNCHANASCLYSDILRDYECICNEGFEGNGYSCEPEVISCTIVDNCDPQATCAYDETLGKSKCICNPGYVGDGYYCTISVGCTSNQDCTVTEECVITPSQKYECICREGYTRDTQNQCVLIAGSCGGGTCVDNAECIYDEEYETFYCHCKNGFIGDGITECKKKVIGCDTLNNCGEHATCKYVEEELAYKCFCKDGFFGNGFDCYAERNCHIDPTMCHQQAVCLTDASRRFLCQCKPGYVGNGTMCKAISKHEGNYLLLNQGMATLQIPLDRTRNKVKKPVQVKAYQTAVGLDVDCLEGRIYWSDISGRAISSSALDGTDKEHFIVNDIGSPEGLAIDWVARNVYWTDSTLDTIEVANIESKLRRTLFNTGLVNPRGIAVHPQRGKIFWTDWNRKDPKIEWSNADGSDRRIFLQGSDVSLPNSLTIDFETEQLCYADAGTKKIECVNIDSKQKQTIASNCTYPFGITTTDKEIFWSDWITKKIERVEKYNLKRLPPLPVPLGGTGNRLFALVAVANKCPSLTNVCEYYKNQCPKDHICLPNGLGGKQCLCGKDSQNNDVTPSCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FT96</accession>
    <name>A0A6P7FT96_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription termination factor, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114332404</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138007.1">
        <property type="nucleotide sequence ID" value="XM_028282206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FT96"/>
    <dbReference type="FunCoup" id="A0A6P7FT96">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282206.2">
        <property type="protein sequence ID" value="XP_028138007.1"/>
        <property type="gene ID" value="LOC114332404"/>
    </dbReference>
    <dbReference type="GeneID" id="114332404"/>
    <dbReference type="KEGG" id="dvv:114332404"/>
    <dbReference type="CTD" id="34837"/>
    <dbReference type="InParanoid" id="A0A6P7FT96"/>
    <dbReference type="OrthoDB" id="75923at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF6">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028138007.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="45204" checksum="295224F43401079D" modified="2020-12-02" version="1">MLKRLYIIMKSTTLILNHLSCVHRISNGHQSNFFSFLKHPVRNYHFIPLLSIKRLASTTQVDSNNNSDVSKKLQDILNIRAVKAHTIVTNNTLFSKVSPEDIENNYKLGLSNHLTRENFKLYPNMLADQSLSLKLEVLKMLPFDFNVTAPLLLVSYAKLKSFVFDELAAKRINEFARIFQVDENEVCKWMSQKIFLMSANMQNIKKCKKILQASGVTLEEIINDLWVLRYNATTVEERIRMAKENNVDTIKTWMVRAQREIFDNYVRRRSDNKEILGEKASLAEYLSEKLECSQEVSKYLILKQPALQKKSLKKMNDIIDFLLQKGFKPIHICRTPKILLHSVNTIKKRLQEIEANNVQLDSLVILTKSQRQYAHVLDSMKSTKTKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FUZ5</accession>
    <name>A0A6P7FUZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Paired box protein Pax-5 isoform X4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114331378</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136748.1">
        <property type="nucleotide sequence ID" value="XM_028280947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FUZ5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028280947.2">
        <property type="protein sequence ID" value="XP_028136748.1"/>
        <property type="gene ID" value="LOC114331378"/>
    </dbReference>
    <dbReference type="GeneID" id="114331378"/>
    <dbReference type="KEGG" id="dvv:114331378"/>
    <dbReference type="CTD" id="43825"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="55"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028136748.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="56312" checksum="24E3CF2FBD04586B" modified="2020-12-02" version="1">MITMECQPGGHGGPLGHSMMLDPSGGGMHQQESDHKKKLFSGDGGSHVGSSSSDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEGICSQDNVPSVSSINRIVRNKAAEKAKHAHQIATSNAASSVSGGPVSVIAHAPATQLNEPRSGAYSINGILGLQHDPNGNSIKRKRIDDHDENKDMNGHPEDDFKRQRSQYNGDQLYSNLWTPGKWNIKDEHKLLSELGGAGTTTGQTGYYDTHAGFGGVSNVSSASDIYDTINTMSQATSQNLYTPPLAGSLAETSSPYNGVVGLGAAVDGSSPGLPLALPAESGSQPASHTGSPDPAALTVLQPSNGASQHYTTMLPNFGYSTTAGTTMVPGTDYAYSTAYSQYGAAYGTYGYGSASSGLLNSAYYYNDITANGINSNEPAQISCVNSNANTDQSSRSPLAATRANSLASANSPTESGSACLKTENIFTHDLNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FVZ8</accession>
    <name>A0A6P7FVZ8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114334676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114334676</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028140581.1">
        <property type="nucleotide sequence ID" value="XM_028284780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FVZ8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655906.1">
        <property type="protein sequence ID" value="XP_050511863.1"/>
        <property type="gene ID" value="LOC126887954"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FVZ8"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028140581.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13820" checksum="773F443CB81258D2" modified="2020-12-02" version="1">MEEDEAFVDENVPRRSLRIALIELNEHIPDTPKSTNPEEMLVIQRGPRKKPITWSPVDYHKIGSLLAPSRDRTPEPVVTKSEINPRLRRRLIMSPSKSPSQEMDVFIAKKLRALKNISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXM4</accession>
    <name>A0A6P7FXM4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein roadkill isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114335217</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141216.1">
        <property type="nucleotide sequence ID" value="XM_028285415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655113.1">
        <property type="protein sequence ID" value="XP_050511070.1"/>
        <property type="gene ID" value="LOC126887500"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655115.1">
        <property type="protein sequence ID" value="XP_050511072.1"/>
        <property type="gene ID" value="LOC126887500"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FXM4"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18345">
        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="63"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="232"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028141216.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45871" checksum="F7645141D2796559" modified="2020-12-02" version="1">MAIFRDFKLPGVSDCSAGQTARVTSNLHPTSTMAVSRVPSPPPQEVNTPVAENWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTIFCEVSVVADSVNISGQSNTIQFKVPECRLSDDLGLLFENQKFSDVTLSVGGREFQAHKAILAARSPVFQAMFEHEMEERKHNRVDITDVDHEVLREMLRFIYTGKASNLEKMADDLLAAADKYALERLKVMCEEALCTNLSIENAAEILILADLHSADQLKAQAIDFINTHATDVMDTPGWKSMIQTHPHLIAEAFRALATQQIPPIGPPRKRVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYI6</accession>
    <name>A0A6P7FYI6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ran-binding protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114335514</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141566.1">
        <property type="nucleotide sequence ID" value="XM_028285765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYI6"/>
    <dbReference type="FunCoup" id="A0A6P7FYI6">
        <property type="interactions" value="1388"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285765.2">
        <property type="protein sequence ID" value="XP_028141566.1"/>
        <property type="gene ID" value="LOC114335514"/>
    </dbReference>
    <dbReference type="GeneID" id="114335514"/>
    <dbReference type="KEGG" id="dvv:114335514"/>
    <dbReference type="CTD" id="36102"/>
    <dbReference type="InParanoid" id="A0A6P7FYI6"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000011">
        <property type="entry name" value="RAN binding protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028141566.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="64603" checksum="23BB0B7323B2DDC7" modified="2020-12-02" version="1">MADVCSGQSVMDLQTEMQNSAVDRLKRLYPAVNEEKTPLPRAWSTKDKYTYIGLSQTNLRVHYKGHGKTHKDAASVQATHPIPASCGLYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKQSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCGVNLIDSTCFYTKNGHYLGTAFRDLPPNLYPTVGLQTPGEVVDANFGQEPFVFDIEDMMRELRSRTRIEINDFPVPESQGEWQATLNKMVSTYLVHHGYCNTAEAFAHITEQPFNEDIGSIKNRQKILKLVLAGRMGEAIEKTSRLYPGLLENNQNLLFMLKCRQFVEMVNGSDIEICHKKTSVCGLSPNSQQMSVIQSTKCLKNKSGSQESIDEMNRNNTARNGSNCTNDSPIISTDDCEMEEMDASDEVQNGHGESCINGKSSTSSNNGYQNGNSSNNIDEAPEILTTCCDNEEEDMDVDVPCRKSNTKQSVERILDFGRELYSMSQRLKIDKSSNNINEKMLEDAFSLLAYSNPWASPVGWQLEPTQRESVCASLNSAILESNSKPRKPPLEVAMAHAQELVRLMSSSGLGSCAFASLIDILDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZ12</accession>
    <name>A0A6P7FZ12_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Interleukin enhancer-binding factor 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114332475</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138073.1">
        <property type="nucleotide sequence ID" value="XM_028282272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZ12"/>
    <dbReference type="FunCoup" id="A0A6P7FZ12">
        <property type="interactions" value="1710"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282272.2">
        <property type="protein sequence ID" value="XP_028138073.1"/>
        <property type="gene ID" value="LOC114332475"/>
    </dbReference>
    <dbReference type="GeneID" id="114332475"/>
    <dbReference type="KEGG" id="dvv:114332475"/>
    <dbReference type="InParanoid" id="A0A6P7FZ12"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000093">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="8">
        <location>
            <begin position="25"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028138073.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43701" checksum="81EE6DAF99E14577" modified="2020-12-02" version="1">MARGGMRGRGGMNRNVGGRPPFKVKMFLPRHPFDLALCETSFPRTKAAPDDTAFTQALLKRNADLSPTPGEQTAILNLVTKIQTVLDNLVVAPGNFDACQLDEVRQVGSFKKGTMIAGHNIADIVVILKTLPTREAVEALGNKVRDDLRNLMKNEIVQKGEQLAHTTNERGIEIRNAFACVRVMVTTLHHNIRKLDPEIHLDQKIMLSHLAAIRHSRWFEENARHSSIKVLIRLLRDVRSRNEGFEPLTPWMLDLLAHFAIMHNPSRQALPLNVAFRRVFQLLAAGLFLPGSAGITDPCEGVSLRIHTTMSLEQQDICCLTAQSVVRVLAHGGYKHILGLEGNANIAQELTVWDGIVVSPLDKAYENPPERKEGDEDEDMEADGDESMETQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1P8</accession>
    <name>A0A6P7G1P8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114336695</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142859.1">
        <property type="nucleotide sequence ID" value="XM_028287058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1P8"/>
    <dbReference type="FunCoup" id="A0A6P7G1P8">
        <property type="interactions" value="2105"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650269.1">
        <property type="protein sequence ID" value="XP_050506226.1"/>
        <property type="gene ID" value="LOC126884328"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G1P8"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028142859.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34055" checksum="D4BBC4B6F6829867" modified="2020-12-02" version="1">MVSILNSIDTGHEDMIHDAEVDYYGLRLATCSSDNSIKVYDIKSGASTLLDDLKGHYGPVWQIAWSHPKFGNLLASCSYDRKVIIWKEQQRKWIKYYEYANHDSSVNSVQFAPAELGLILACGSSDGSISLLTYNVGSNIWDAKKIQNAHAIGCNAVSWAPAITPVFGDETTPVKRLVSGGCDNLVKIWREDGDRWIEESKLEVHSDWVRDVAWAPSVGLHRYTIASCSQDRRVVIWTSNDCINWNSTVLHTFDDVVWNLSWSLNGNILAVSGGDNKITLWDQNSEGSWQCISDIAKGQGQINNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G205</accession>
    <name>A0A6P7G205_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450 9e2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114335087</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141047.1">
        <property type="nucleotide sequence ID" value="XM_028285246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G205"/>
    <dbReference type="EnsemblMetazoa" id="XM_028285246.2">
        <property type="protein sequence ID" value="XP_028141047.1"/>
        <property type="gene ID" value="LOC114335087"/>
    </dbReference>
    <dbReference type="GeneID" id="114335087"/>
    <dbReference type="KEGG" id="dvv:114335087"/>
    <dbReference type="InParanoid" id="A0A6P7G205"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028141047.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="60586" checksum="5767972948568D2D" modified="2020-12-02" version="1">MAALMLAFVLLCTFLYYSFFIKPMNYWKEKKVFHLSALGSFLRTVFSGKSFFDATLDLYRKYPSRRYFGNYTLLKPTLFVRDLDLIKAITIKDFEHFTDHFTFFQSDPILGNNLFELQGERWKDMRSTLSPAFTSAKMKGMYAFIEETAENFTKHLYDMNTEEIELKKEFTMFSNDVIATCAFGINCDSFNNENNDFFSMGTELITPSPRRKLRMFFSLMFPKIFKAIGIPIISQNILNFFKQIVIENMETREKHNIFRPDMIHLLMEAKKGRLKVETNKVDQDDGYAVVQESTIQKSIRKMEITDNIIAAQAILFVIGGLDTNSTTLALMSHQLAIHQDIQRRLQQEVDEVFKQCDGKLTYEEVLKMKYLDQVISEVLRRYPLGYAIMRKCVKDYKIESFKRSESTFILEKGASVTIPIVGIHMDPFLFPNPEKFDPERFSDENKKLIIPGSYMPFGSGPRNCIGSRFALLECKTVMVHLLRKFDIVPTKNTRNPLRFKKNITVSSKDGFWLGLRKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4I6</accession>
    <name>A0A6P7G4I6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114335836</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_028286126.1"/>
    </dbReference>
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        <property type="interactions" value="2064"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_028141927.1"/>
        <property type="gene ID" value="LOC114335836"/>
    </dbReference>
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    <dbReference type="KEGG" id="dvv:114335836"/>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="8">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028141927.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23672" checksum="B5D368F8A608F614" modified="2020-12-02" version="1">MGKTKKTRKIVERRFAKMKKMISLSDPRIKESLRQASKKKKPEDPYEVKVNEAPQISSALFFQYNTQLGPPYHILVDTNFINFSIKNKLDIIQNMMDCLYAKCIPYITDCVLAELEKLGQKYRVALRIIKDPRFERIHCMHKGTYADDCLVQRVTQHKCYIVATNDKDLKRRIRKIPGVPIMYVSQHKYTIERMPDAYGAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G4Z4</accession>
    <name>A0A6P7G4Z4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">snRNA-activating protein complex subunit 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114335970</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028142072.1">
        <property type="nucleotide sequence ID" value="XM_028286271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G4Z4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286271.2">
        <property type="protein sequence ID" value="XP_028142072.1"/>
        <property type="gene ID" value="LOC114335970"/>
    </dbReference>
    <dbReference type="GeneID" id="114335970"/>
    <dbReference type="KEGG" id="dvv:114335970"/>
    <dbReference type="CTD" id="40949"/>
    <dbReference type="InParanoid" id="A0A6P7G4Z4"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="336"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="336"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="395"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="443"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028142072.1"/>
        </source>
    </evidence>
    <sequence length="869" mass="101581" checksum="5505338E645DAB8A" modified="2020-12-02" version="1">MDDEADLRKLEETLEECRAEKLDEAYQGFIDFDDSEEEDNVSSINELDSSFEDNYEPVISTEYKYSVLTSLTPEEKSVIDSCEDFDLKHILILNRQKNMSLIEHYKKFKDLLIECQSNMSDINRIIHEKNNNKKSTTRSSKAWRLGAPYFKDKLNFPAPLNDEALQKKLCDEQTIYDSLKSFNRWSSHECDSVTRAVKLNYSINTLTHIRNEIKKLEGSNDRNKNEKIIELQEKQKRFEDTDNLPIPPLGSDERINWIRVAEVFFRDKHTDFECRSMWHMFLHPQLNKSPWRSEETNKMLALVKKHKRQNWVEIAKELGTNRTCFSVFINYINNFHSKLKKGGFTPAEDKKLANLVRKFRVGDYIPWTKIARHFRYRERSQLHHRFKYFLNHVDKKQGKFSLAEDCLIYICVEKFGMAYHEVTEHLKDRSRTQIRTRYITCLKLDAKKNTWTEAEDDTLIRLREQQTKMDWTTIAQTLRRTPGQTRQRYHVIKKYLEKNSGSTIMNVPRRIHVKEENNSVLKQVANIFGAQNVIPTLEEIGEILSNYLNEPLSSQNDSVEDIDVLLYDFFLSTSDQSLEILSDPLAVKRVVDYVEYLMNFLKVDVDIPKNLAKCPHIDSLDKKLLSEIRTRKRKKPVVFSSNPIKDCIAPNFYTTNGMRALLERNFKFRSDPVGKIFGNYLDEPDISLQKFKCEINNDDSESTILFKETIEMDRKLFFSRFVTLFDWPGIISLESPHKDLVSICKPLTVDYSRKSTPTNVTKTYSRKRGSQATTDTSQEQQSNKVIIVEEDGSESRHSKKSFSNKTYGTAQKILTKKMDLNIFTSVQMDESKPCSSTMAGIIKDWYSDDSDHESYNAKESTSAENLCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G510</accession>
    <name>A0A6P7G510_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114337742</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144066.1">
        <property type="nucleotide sequence ID" value="XM_028288265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G510"/>
    <dbReference type="FunCoup" id="A0A6P7G510">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288265.2">
        <property type="protein sequence ID" value="XP_028144066.1"/>
        <property type="gene ID" value="LOC114337742"/>
    </dbReference>
    <dbReference type="GeneID" id="114337742"/>
    <dbReference type="KEGG" id="dvv:114337742"/>
    <dbReference type="CTD" id="51256"/>
    <dbReference type="InParanoid" id="A0A6P7G510"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000028">
        <property type="entry name" value="TBC1 domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="48"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028144066.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33753" checksum="100725435702198B" modified="2020-12-02" version="1">MADERNFRSAYYEKVGFRSVEEKKSLEILLKEKPLDRGKLRQFCVRFSVPATYRNLVWKLLLGVIPVHIDSHNFIMDQRKQEYHELHRALTVMRVIDTNTPKPQVFLAMWLLQTGNFTIDTSLATERGFTNIVQSFMQFFEDDADVFWLSRNFYENVKKFDADLGKVVEKTYVILEKEDAAYYKHLSKTGVLDNLPLAKWFDCCFAGILYKSALERIWDKLCGGSYKILAFVAVVVLTTLKARIMKCNNISAVLQIIKNISEETADVIANKSIEMWQQYGTPLTVHDKPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6I6</accession>
    <name>A0A6P7G6I6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Facilitated trehalose transporter Tret1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114338275</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144669.1">
        <property type="nucleotide sequence ID" value="XM_028288868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6I6"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288868.2">
        <property type="protein sequence ID" value="XP_028144669.1"/>
        <property type="gene ID" value="LOC114338275"/>
    </dbReference>
    <dbReference type="GeneID" id="114338275"/>
    <dbReference type="KEGG" id="dvv:114338275"/>
    <dbReference type="InParanoid" id="A0A6P7G6I6"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028144669.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="52540" checksum="6C57787371711065" modified="2020-12-02" version="1">MTVLAYENLFKGTLFQLLAVLSGTLNAISDGMQYGWTAPVLPILLGPDSPVPITEWEGEMLETFLWVGSLSCLPLTMYLVDKIGRKNSILLAAVLTLTVWVITALAPSVEYLYVARFLAGTASNTAYVSTPMYIAEIAEQKIRGFLSSLIYLMMLLGIFLIYAVAPYIPYYAHCTLGAILACLELGIFPFMPESPYFLVFKGKHEEAKKSLEWLRPEGADVETELNEINAAIERQKTEKDKIWDLFIVPSYRKGIIIMFVLNGAQHFSSISVLLMNLHIILEAAGSTYIDPATAGILFAFILLLAATVASVSVDKYGRRTLLISSSLLTGICLFILAVYFTVKNSGYDTASVSWIPIVCIMVYACVFKLGLGLVPIVLAPELFPANVKGYGMTLVDATYVIASLLSLQIYQRLADNFGLEYPFYVFSISCIFTAIFSYFVVPETKGKSLEEIQMILKGNNKEKEKEKDIENTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G839</accession>
    <name>A0A6P7G839_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114338867</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145301.1">
        <property type="nucleotide sequence ID" value="XM_028289500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G839"/>
    <dbReference type="FunCoup" id="A0A6P7G839">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028289500.2">
        <property type="protein sequence ID" value="XP_028145301.1"/>
        <property type="gene ID" value="LOC114338867"/>
    </dbReference>
    <dbReference type="GeneID" id="114338867"/>
    <dbReference type="KEGG" id="dvv:114338867"/>
    <dbReference type="CTD" id="36405"/>
    <dbReference type="InParanoid" id="A0A6P7G839"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="67"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028145301.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30666" checksum="A04635CBBFB91249" modified="2020-12-02" version="1">MGYNLDWIMPRLRSPTTFWKVASALTVCAVGLFSKILIRNNLLNRAKVYNRNVMSNLLDNRPKHVPLITVSNHHSCFDDPGMWGTLKLRQLLSPKTMRWSLAAHDICYTCAQHAHFFSLGKCIPVVRGAGVYQDAVDFCIEQLAKGGWVHIFPEGKVNMTKENMRLKWGVGRMIYEAPVTPIVLPIWHIGMDDVLPNEPPYVLKFGKNLTFNYGEPLDLSEMVQALREKKATEEEARRHITDFLQETLLKLKDKTEELHRKSHKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCM4</accession>
    <name>A0A6P7GCM4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114340550 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114340550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147104.1">
        <property type="nucleotide sequence ID" value="XM_028291303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCM4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050656390.1">
        <property type="protein sequence ID" value="XP_050512347.1"/>
        <property type="gene ID" value="LOC126888279"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GCM4"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028234416" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028147104.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="11585" checksum="82A65FC6893AA9EC" modified="2020-12-02" version="1">MFRFTLFVLAIIVTLSNAFYIPSYLYDRPQYLLPPQLRDIYIQGRGEGGVNVDPMDINILGLEGTVGGKVEGRGEGFVQINTNKATPRPDYYGVPCLNIARCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEP5</accession>
    <name>A0A6P7GEP5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC114338385 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114338385</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144777.1">
        <property type="nucleotide sequence ID" value="XM_028288976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEP5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288976.2">
        <property type="protein sequence ID" value="XP_028144777.1"/>
        <property type="gene ID" value="LOC114338385"/>
    </dbReference>
    <dbReference type="GeneID" id="114338385"/>
    <dbReference type="KEGG" id="dvv:114338385"/>
    <dbReference type="InParanoid" id="A0A6P7GEP5"/>
    <dbReference type="OrthoDB" id="7419171at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF14">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028335539" evidence="4">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144777.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27615" checksum="C7C74C49CA771545" modified="2020-12-02" version="1">MKLLFVLSCVLFVQSAKKLPSFVEVCPRDNKEASECLARNVKNLTPMLGKGIPELFIPPLAPLVLQSAEIATSPSFTCSLKNAKVYHLDSIVMTDVFINFDTKSWGADVFFPVIEVESDYKMNGKILVLELNSEGKSRGNMTNIKTNVLVFFDVVTRNGKEHLHITDTKIKMDIEKCAFEFDDLFKGNEDLTQRANQILNQNYKVLLEEFSPVFEKIIATLTENVVESIYKKYPFDILYPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNU7</accession>
    <name>A0A6P7GNU7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114340318 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114340318 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC114340318</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028146858.1">
        <property type="nucleotide sequence ID" value="XM_028291057.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028146860.1">
        <property type="nucleotide sequence ID" value="XM_028291059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNU7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050655302.1">
        <property type="protein sequence ID" value="XP_050511259.1"/>
        <property type="gene ID" value="LOC126887667"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10455193at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044651035" evidence="1">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028146858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028146860.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28265" checksum="2DBA294CBEDAB292" modified="2020-12-02" version="1">MKVFLVLAAFATLCAAKPTFLLDSLVIHKVAKGLGLGNVISVDGDARAKLGQNEIGVDLAGGIGGDVVGYHAKVDGNVLGQKVNVHGDIYDGDKVDAKNHQVYTDENGLQYILVRQYVGTNSLLVRKYLISGKMVIDGTNQPLDINARYPDTTVDVRYPNINVNVERPGYKIVQITYPDGTLRPMYVRIEEPNLPPGYIRVYDPTVPIGYRIVRIETPEVPVDPIRYTVIRTPNVQVNPIQIERVQPEYKTIRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GNX8</accession>
    <name>A0A6P7GNX8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 112-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114344989</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151606.1">
        <property type="nucleotide sequence ID" value="XM_028295805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GNX8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653649.1">
        <property type="protein sequence ID" value="XP_050509606.1"/>
        <property type="gene ID" value="LOC126886653"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8300205at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000161">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028151606.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="60719" checksum="116D35E7B11803FA" modified="2020-12-02" version="1">MEFNTEIDEKFVEYNQKYILTQLSTSRDLKNEPEKYKSAMELKLKIKEESVESGQRYVESQPCTSLDHKELKNEPEENSSDMGVKLKIKEEFAEDDQGYVESLLITPQELRDLKNEPCEDKLGLSYKKNRTEIVETLPEDSFNKKQISLNFEEVTINNSICSKDVSSKNNLDEHMNIETGEGLHKCEICFKKFTRIASLKKHLREHTGETPSKCEICFKQFTRTASLKIHLRVHTGETPYKCEICFKQFNRIASLKLHLRVHNGETPFKCEICFKQLRDSHSLKRHMRVHTGEKPYQCEICFKSYTEASDLKKHLKVHTEETPHKCEICFELFSQASDLKKHLRVHTGEPFKCEICFKHFRDSHNLKRHMRVHTGEKPYQCEICFKSYSEASDLKKHLKVHTGETAYPYKCEICFKPFSQESDLKKHLRVHTGETPYKCEICLKQLRDSHNLKRHMRVHTGEKPYQCEICFKSYTQASDLKKHLKVHTGETPYKCEICFKTLTTASTLKSHMILHTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSG7</accession>
    <name>A0A6P7GSG7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-like GTP-binding protein Rho1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114346185</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152766.1">
        <property type="nucleotide sequence ID" value="XM_028296965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSG7"/>
    <dbReference type="EnsemblMetazoa" id="XM_050663234.1">
        <property type="protein sequence ID" value="XP_050519191.1"/>
        <property type="gene ID" value="LOC126893248"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GSG7"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028152766.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21935" checksum="E04F454BC78EACB6" modified="2020-12-02" version="1">MSKIKKIVTIGDGACGKTSLLTTFSFNAFPERHVPTVFDAYSKDIEVDDQTVTLALWDTAGEEDYDRLRPLSYSRTSVVLICFAVDFPDSLSNVKDKWYPEVKHFLPYVPYILIANKLDLRTDPETIKTLADRNQHPVSQEEGERMAKKIKAVKYMECSAKHLFGIRPIFEEAARIALETKTKSKIKHCKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GU42</accession>
    <name>A0A6P7GU42_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 64-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114342922</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028149527.1">
        <property type="nucleotide sequence ID" value="XM_028293726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GU42"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645241.1">
        <property type="protein sequence ID" value="XP_050501198.1"/>
        <property type="gene ID" value="LOC126881162"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GU42"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028357203" evidence="1">
        <location>
            <begin position="17"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028149527.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="16352" checksum="26D8861DA39F471C" modified="2020-12-02" version="1">MFPIIFLVLVASAANAGNIGIGLNSGGYGGLLGSTISQQATSTSIANSGPVAVAAAPVAVAAASPVLAVSPLAVASGAIVSVPTATSSQSRVDVINSRPLVSQVVSSVPVNVALGGGYGNGYGTGYANGVIDNGLVASAGLVTGSVNAVNSVGYSNVGYGNVGNGHGYRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GWE2</accession>
    <name>A0A6P7GWE2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Surfeit locus protein 4 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114343732</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150372.1">
        <property type="nucleotide sequence ID" value="XM_028294571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GWE2"/>
    <dbReference type="FunCoup" id="A0A6P7GWE2">
        <property type="interactions" value="1738"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294571.2">
        <property type="protein sequence ID" value="XP_028150372.1"/>
        <property type="gene ID" value="LOC114343732"/>
    </dbReference>
    <dbReference type="GeneID" id="114343732"/>
    <dbReference type="KEGG" id="dvv:114343732"/>
    <dbReference type="CTD" id="6836"/>
    <dbReference type="InParanoid" id="A0A6P7GWE2"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028150372.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30682" checksum="BF68ED5C1DBC6561" modified="2020-12-02" version="1">MNIPNEYVSNAEDIADNVIRKLKHILPTLARVCLISTFLEDGLRMWFQWTEQREYMDLSWGCGKILATLFVIVNLVGQLGGCVMVIIRYRVNIACGVLFFIVVLQTLAYSILWDLQFLFRNLALIGALLLVLAESRGEAKSLFAGVPSLGDNKPKNYLQLTGRVLLAFMFITLIRFELSFLQITLDLVGSLLMVMVTVGYKTKLAALTLVLLLGTLNFYHNAWWNIPDYKPLRDFLKYDFFQTLSVIGGLLMIVYLGPGGVSMDEHKKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAG8</accession>
    <name>A0ABM5IAG8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028128582.2">
        <property type="nucleotide sequence ID" value="XM_028272781.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128583.2">
        <property type="nucleotide sequence ID" value="XM_028272782.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272781.2">
        <property type="protein sequence ID" value="XP_028128582.2"/>
        <property type="gene ID" value="LOC114324884"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272782.2">
        <property type="protein sequence ID" value="XP_028128583.2"/>
        <property type="gene ID" value="LOC114324884"/>
    </dbReference>
    <dbReference type="GeneID" id="114324884"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052446">
        <property type="entry name" value="B-cell_PI3K-Signaling_Adptrs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017893">
        <property type="entry name" value="DBB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267">
        <property type="entry name" value="BANK1/PIK3AP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267:SF11">
        <property type="entry name" value="STUMPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14545">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01282">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51376">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBB" evidence="3">
        <location>
            <begin position="380"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="812"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128582.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="975" mass="111867" checksum="82C5A52B81C637C6" modified="2025-10-08" version="1">MDFDNPSYFSMANGNRPSERKETWGSTETSFIKQLTPPRGGSWYKERRMYLRSVSSNSADSNQELLIKGEPRLSDIAPDLSFKGPPSRSSSIKSQKSDFITDLSYLPRTLSEEPVDIFSENEVFDSENTERYHNFTPMERTSQRRHSIGTFVAAPVDNRQTIKQSDTNLSTTLSKNVKEVEVEIHSTRQASYPRKRCIKSGKGTPKNINMDDILIISVEKSEAASLWVDYFSNYFQQISKHANRKPFRIQHSSLEEIISKTEEEHADFISRATSVKLQLVVMCPSFLEIVADRSEECMLLEKILLAEKTLALLLGVTDDDFNEVHKKVLPTYFQWHRKCVGHDQDENFTKEFLGQAMTILSKVWKQQMSIISQDKSYFSISPKKIRQGQNSVLVILTFPLQKDDVVKISVEKNGELFVINNVKKRNPYLLKFWMPESLTEITAIVNILVEKNGNIIGSRPMKCESRLRELEEILRNVNNPIDFMCQSIGFSPSERDNIDNWLVHNFQRNLPPHFNILGHYEQRHVNGATQGYKRSHEEFPTLLHFSAKFGLEKLTLQLLECPGADVAYEIRNIYDLTPLEMAEANGFSEMATMLRGVININEFTSIYAKLMEMSLTPKPGDRECDGYMVPKSMQQFYKICPAPRPVIKDDNLNFPSTSSNEWQPNLEYIPMHTPVSVPKEEQPLLQRNNSVNKEEPIITICEESIDAMNKSMRKNKKSEDVEDRVQKELAEIINDFKNNIHSITQAERLVEEWKNRNDVQKSFKEKQEQLTEMRIKYDQIQSKMKTAMKKPTPFERMRKLFSKPKHDHQQINSSANSDSSSLNNRPLRSLSTSSSGSSGRVSSISACSLGDSGTLSDNEERALMLGKHSEEEIRNDLNKAVMELNYNTLPIPKPKKLPIDHSYQLIEESSLVGSLDSPDDFYIQYPPSGLPIPGFEDYQRQESFGNEYTNIEASKTTQTTHEYMNFKVPTLSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IC55</accession>
    <name>A0ABM5IC55_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028129609.2">
        <property type="nucleotide sequence ID" value="XM_028273808.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273808.2">
        <property type="protein sequence ID" value="XP_028129609.2"/>
        <property type="gene ID" value="LOC114325677"/>
    </dbReference>
    <dbReference type="GeneID" id="114325677"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045865906" description="Histidine-rich glycoprotein-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129609.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26996" checksum="F51385280ECF4500" modified="2025-10-08" version="1">MRKVVVFLGVLVLAVLVRGHALKGEEEELQLDQAVAASGHGHHHESGGGHEGHEHHHESHGGKGDKGYHSHHHHDKGGHGKHGKHHSAGHHAEKGGHHKSHHESGGHHSSHHAHGGHHKGGKFGEKKGHKKGQKTKGYHVKAHKDEHHKKHKFYDDAHKGGHHSKHGSHHGHHGSKAGHHKKGGSHKSGYHDDHFGKKGFGHKGHYDEDHKGHKGHGGHESHHSHHSDYGKKGGHEGHSSHGFSSGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ID69</accession>
    <name>A0ABM5ID69_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein artemis-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028130243.2">
        <property type="nucleotide sequence ID" value="XM_028274442.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274442.2">
        <property type="protein sequence ID" value="XP_028130243.2"/>
        <property type="gene ID" value="LOC114326178"/>
    </dbReference>
    <dbReference type="GeneID" id="114326178"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130243.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="70822" checksum="884A7762E9213984" modified="2025-10-08" version="1">MSTFGGKIQEIENISIDRFIGENLFSEAFFLSHCHTDHMEGIWSDEFNQQLEDNNKILYASQISCKILEQMDHCFKYHCKALDLMVPTTIYLKDSHFSVTLIPAGHCPGSVMFLFESDKRILYTGDYRIRKSDISKFNCFFDNEGKIKVIDKIYLDTTFFHKKYLNFPKREESLREICEIIEEWITKGKDFHIYLDTSAKYGYEYLFKEIFMKIGMPIHINYDANKLYSLVPELDCAVTSNSDITQLHSHCFGWRRRCTFSDDSNVKTIKVSALRWDQEDLAQGLSEYKSGIHYVCYSTHASYEEGVEFIRFFKPKEIDICVKHQDPQLNREMSDDIDELVKEFHVENRIIVMPKLFNTDRKRKKFKSNKRHSTSQILNSPPRLSFVEGCEIKSENISYQVSASKEKCIIESTSKEEYVSLALFDTDTHDKNSLSLPSSPQKVLPMKRSIDTVDEADIVNVIKPLNQKEEVEESVQNCKIKSENVSYQVSAYEEKCIIESTSKEEYLPLALFDTDVQENNNLSLPSSPQKDLSVKRSIDTVDEAEINVVEPLNQMEEVEDSVLFNLIFTPPETSSEDIKEHVEVDTRTDNLEDEDSVILKIINFSYDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IG63</accession>
    <name>A0ABM5IG63_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 and multiple ankyrin repeat domains protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028132023.2">
        <property type="nucleotide sequence ID" value="XM_028276222.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276222.2">
        <property type="protein sequence ID" value="XP_028132023.2"/>
        <property type="gene ID" value="LOC114327524"/>
    </dbReference>
    <dbReference type="GeneID" id="114327524"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17091">
        <property type="entry name" value="FERM_F0_SHANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06746">
        <property type="entry name" value="PDZ_SHANK1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="610"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132023.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="143363" checksum="B772620D1999AF1A" modified="2025-10-08" version="1">MSMLWRRRKRKEILEDMWSFTSTSTCEELARLMEEEDERGPEEGHLLVRIHVPELNVQKCLQFPRDQLVWDVKQQCLAALPKVATWYRELKESFNYGLFCPPDNGRAGKFLDEERRLGDYPFNGPVGYLELKYKRRVYKMMSLDEKQLKSLHTRANLRRFIDYVQNGQVEKITKICSKGLDPNFHCQETGETPLTIATGIKKPAKVLMALVNGGALLDYRKKDGSTALHRAVEHRSLEALKTLLELGASPNYKDNKGLTPLYYTITLVVDPTFTETLLHDHATTGAQDAQGWQEVHQACRTGLQAHLEHLLFYGADMNAQNASGNTPLHVCAVNGQESCARQLLFRGADRQALNYANQTPCQVAVIAGNMELAEIIQKYKQEDVVPFRGPPSYNPKRRSAIGWLNRAPSMSTLALPPSPCPSDRSSAPFSSASSSLSEGSALPGHETDTASIVTVFALGVTDKSLGDTSDIISDSSGVGTANSDTTNCTIWMPGSTVVCIESYTSKEDGHISIREGDIIEVLAATDDGYLEGKIKSGGGRTGYFPASCAQEVRLRHHNIQAPMMVAKDPRPPSQTSSRVLGRRESTSKHFATAPRTTKKSFANLPAEPRTVVLHKGKKGFGFILRGAKATSPLMDLTPSDKCPALQYLDDVDPGGVADIAGLKKGDFLLEINNEDVSSASHEHVVDLIRKSGDLVQMTVMSLGPPVCGVLPMSKSTILPGGTGTIPLSSRFATLPRKAVTYGGTLGRSTQAPLPPRRDPKTTLSVGRARAKSMVAGLGGEKDETDDITKSSSAESIHQSTPGSTCTSTPVQPRTASIRQRPSSTSLKHSVLEELFQKQKESSIMSQSSLMSSSRFQCSNSSGSPSKGRVYASVAEMKRSKSKNPKVKFTELFTGGKELKRTFHSTPDLVQDLAYNCQTLPSKFHRSQEDISLLLGNRSLPPPSHPPPPIPSHVQLVKVDVSRGKHSEYDHLNREIPDEGIVSSFNPTASAKLYASPEDMKTVGYRSKSLPSHTSKTQIRKSQSMRTNNTFKPTNNNNVSNKVPADTQQSNPYAQPIRASRSHSTGSRERRKKVPSSKSNPKLSQQPGAPPIPEPDYSCTDSEGESESVPRKTDSLASRINSIQLQATENSGNSNASGSSSGSSSIPHSFSVEEIQRGRSLLKSSKSYPDDLLKKQKEADAALEDGDNSSSGVSSDQEIMPCGNTELTEQNSIVPGNKNQRAQIGTLKRHAVSLAQLPPPIENETDEKEEFCLPPPPEFGENNPNFSDVVVAPPPQFSDNRQITRVRIVGAVPKGTLAVNTQPKLKQNRLHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IGC4</accession>
    <name>A0ABM5IGC4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_028132148.2">
        <property type="nucleotide sequence ID" value="XM_028276347.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028276347.2">
        <property type="protein sequence ID" value="XP_028132148.2"/>
        <property type="gene ID" value="LOC114327669"/>
    </dbReference>
    <dbReference type="GeneID" id="114327669"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044986644" description="CLIP domain-containing serine protease" evidence="8">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="10">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="129"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132148.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="388" mass="43310" checksum="0EE9D184B86C45E9" modified="2025-10-08" version="1">MEMFCLWFVCVFYSVLFKIADAQRGQPCLTPNGNLEICKSIYDCSHFIRAIIKQNPSELNFIKQSQCGFDTSFLVCCGADVNFVTSRNSSSILRKRELLSVNSSILPDQVSISDRKVCGYQGHMSHLPLATGLGAIKTYLDDHPWMALLGYTTRLGRLKWACGGTLISHRHVLTAAHCVTGEAEVLVGKVTHVKLGAYDKTEEIACDSKGFCTEEAVILGIESFSFHDNYDASDKTSSNDIAIIKLNQTVEYTEFIRPICLPESNRELSIYDWLEIVGWGLTDHGETNVKIKVKLPIRRRELCVRAYRSVGLKLSDSQICAGGIYGKDSCKGDSGGPLLGHLEREKPYQWYQEGIISFGNRDCGVEGLPGIYTKVSSFLPWIHSHIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5II03</accession>
    <name>A0ABM5II03_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133257.2">
        <property type="nucleotide sequence ID" value="XM_028277456.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277456.2">
        <property type="protein sequence ID" value="XP_028133257.2"/>
        <property type="gene ID" value="LOC114328570"/>
    </dbReference>
    <dbReference type="GeneID" id="114328570"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="29"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="659"/>
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    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="687"/>
            <end position="714"/>
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    </feature>
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        <location>
            <begin position="715"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
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            <begin position="743"/>
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    </feature>
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        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
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        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
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        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
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            <begin position="883"/>
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        </location>
    </feature>
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        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133257.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="938" mass="111641" checksum="B201FC2110BA562A" modified="2025-10-08" version="1">MEVKQEISDETYKLEAEYNDDALSDGFKCEFKEESNRPSTQGEGTYDYLDFKEHSINTEIKQHENKLNPFEENQKNEKDFLQDNKTEIMKALTEHSSHGANHMNAEGKTSTQNMEVVTGKRPNKCVICLKRFSEASNLRAHLRTHSLEKRFKCEICLKQFTKKGNLKIHLKIHTGEKQFQCEICFKQFPLKCTLKKHLIVHTEEKPYKCEICFKQFTASSSLKDHLRLHTGKKPYECEICFKQFNQLGNLKDHLKVHTGEKPYKCEICFKQFSHKENLKKHLRVHTGEKPYNCEICFKKFSQLNILKGHLRMHTGEKQHKCEICFKQFSRKENLKTHLRVHTGEKPYKCEICFKQYTQPYDLKRHLRVHTGEKPYKCEKHHKCEICFKQFTRASDLKKHLRVHTGEKPHKCEICFKQFIQASSLKKHLRIHTEENKCAICFKQFSQKEHLKSHLRIHTGEKPHKCEICLKQFIEASNLKRHLKVHTGEKPYKCEICFKQFIEASHLKRHLKVHTGEKPYKCEICFKQFTAPSSLKDHLRLHTGEKPYKCEICFKQFIQLNNLKEHLRVHTGEKPYKCEICFKQFSLKENLKRHLRVHTGEKPYKCEICFKKFSQLNILKRHLRIHTGEKSHKCEICFKQFSHKEHLKKHLRVHTGEKTYKCEICFKQYTQPYDLKRHLRVHTGKKLYKCEICFNRFTTSSSLKSHLRIHTGEKPHKCEICVKQFIEASHLKKHLRVHTGEKPYKCEICIKRFTTSSSLKRHLRVHTGEKSHKCEICFKQFSHKEHLKKHLRVHTGEKTYKCEICFKQYTQPYDLKRHLRVHTGKQLYKCEICFNRFSTSSSLKSHLRIHTGEKPHKCEICVKQFIEASHLKKHLRVHTGEKPYKCEICIKRFTTSSSLKRHLRVHTGEKPYKCEFCIKRFTTSSSLKRHSRVHSGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJC5</accession>
    <name>A0ABM5IJC5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134156.2">
        <property type="nucleotide sequence ID" value="XM_028278355.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278355.2">
        <property type="protein sequence ID" value="XP_028134156.2"/>
        <property type="gene ID" value="LOC114329313"/>
    </dbReference>
    <dbReference type="GeneID" id="114329313"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="375"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134156.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="511" mass="58202" checksum="5DB661C09F37FA17" modified="2025-10-08" version="1">MEKEPQPESMATVTIKPEYTPSEYSASEPPPAYMKMRSTSVQIAKIIAITVVACSVILGGFLLASAYVSANASCRQLEHELELLSEAADRFQSPLQPEALIQDPPSSVNAKRQVETLNVEEQSPTTKELTNHIDDDSSSSSSESESTDSEDLPTKEPKGAKVPVQMDMEELISHLLEKNQKSKMNCVVEKKRAEEFVDHQPKTVRLPFGINLTTNPRFEKLTGERMVIVCESGTMQGAESPMRPKEEREDDSDEEDQETIMIQPVMIPIPQSPFNTHMPQQMAPMAPQRLMGEQMRPMGAPVFHIENMRPPMMHQQPPSQMPVRPPMQPQIQIQMQPQQPQQGDFPPNPILQHIVQQIVAQKIMESQKLREQQMREQQQQQQQQQQQKEVRPEPTQEIEERPRFLQIEQIGQPVNGQRLPIPEEVLTQLNRLPNRDVIVAVSETDSEDAPQEVQYVQEQRQSANEMNGRQTYTRALPINLPVHVAPQDQESQEQEQQQDELRPHFVQPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IMX4</accession>
    <name>A0ABM5IMX4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028136764.2">
        <property type="nucleotide sequence ID" value="XM_028280963.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280963.2">
        <property type="protein sequence ID" value="XP_028136764.2"/>
        <property type="gene ID" value="LOC114331386"/>
    </dbReference>
    <dbReference type="GeneID" id="114331386"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044975977" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136764.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="565" mass="63790" checksum="A3B42575CE77A1CB" modified="2025-10-08" version="1">MVSSRTVGFCLSVLVCSVVCNDYPLVRISDGLLQGAFLKTRNNRKFSGFNGIPFAKPPVGQLRFQPPVPNDPWEGQLNATGVHAECPQRDVYRRSPKISGEEDCLYLNVYTPKLSNFENDLLPVMIWFHGGGLLCGGGNSDWYGPDILLDRDIVLVVTNYRLGPLGFLATGDAVVPGNNGLRDQSLALRWIQKNIRKFGGDPNLVTLFGESAGGSSSNFHMISPLSRGLFTKAILQSGTTLSPWTFSENQETEKNSRKLAKALNCPTDSSQEMVECLRKVEARTFVELDDIFKVWDYDPMIPFKPVVEPSEVEDPFMPDHPLNIIKSGKSMDVPIIVGITSEDGALKNAGYKNANLLDEFADRFDELVPISLFYDRTEKDPQRVTRRLKKFYFGNKRVQDNIQGITDMYTDGWFFKASDDVARLHTKFYKQPVYFYVFGYNGSVSFSKVFGGGDEHFGTVHADDLQYLFPVGDGLFPDVKPSESDKRIAKVFTTLWTNFAKTGNPTPETTTLLPNKWEKYTLENEEYYIIDNDNLETRTGVLRNRALFWRELINDPLKEGKREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR15</accession>
    <name>A0ABM5IR15_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Up-regulated during skeletal muscle growth protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028139246.2">
        <property type="nucleotide sequence ID" value="XM_028283445.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028139254.2">
        <property type="nucleotide sequence ID" value="XM_028283453.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283445.2">
        <property type="protein sequence ID" value="XP_028139246.2"/>
        <property type="gene ID" value="LOC114333553"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283453.2">
        <property type="protein sequence ID" value="XP_028139254.2"/>
        <property type="gene ID" value="LOC114333553"/>
    </dbReference>
    <dbReference type="GeneID" id="114333553"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009125">
        <property type="entry name" value="ATPMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT DAPIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34038:SF1">
        <property type="entry name" value="ATP SYNTHASE MEMBRANE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14960">
        <property type="entry name" value="ATP_synth_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01821">
        <property type="entry name" value="DAPIT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139246.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="5834" checksum="F5999E07E9ABE5EE" modified="2025-10-08" version="1">MAGDSVDASKLTGMSKIFNGSTMRGRANVALATYASVGLLIAYFSLKPSKPKAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IR24</accession>
    <name>A0ABM5IR24_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139258.2">
        <property type="nucleotide sequence ID" value="XM_028283457.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283457.2">
        <property type="protein sequence ID" value="XP_028139258.2"/>
        <property type="gene ID" value="LOC114333566"/>
    </dbReference>
    <dbReference type="GeneID" id="114333566"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139258.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1802" mass="208587" checksum="828F15A50B6CABDF" modified="2025-10-08" version="1">MVDKQAKKPVLEEKHSDDDRYDEDISDLPRPTIIRRPKTPDTGDPVQTAKKKEKEKEIKTKPCTPPCVCNKESVVSTKIEPTISHRLGFKYVYEAPTGTARRVYVSPLKRKEEYFNKPLTNRYHCKYASALMPRPISKRKLEINLAVPSPEPSSAKVALRRATPSPSLEPFSPERPDEEGLEIKKPKSGIFINVKESDKQKPGKVEDYDSFDLVYQRQPRPRSPDYVKERKQKMRERSGLADITEDDETRTPVSKKRKKRSKRIRKKSVTDDELDMDGFASDNYYDGEGEESGAYLTKMFRRKVSLTSAATSYQSRDIPHSTISLVTDAGVDKYIQKFRRDSEMKKFQPKKRKIKRGTLQSHSFTDMYQPILKDFFFGSMQGTMHQGDLSFPESIRNKQGLCMPVAAYCYSMILHPNKWTTETIDKILSYGNQLFMDSIEKNNFYNTDKEFKREDLIKYCIIGCNKMRFSVEDPDITGYIRSDDKRVYNLTKALKIFFYRQTAGIFKTQDISIAIWKNKYLYMFDARPRTKDLYVCCAGTAIMANFYDVTSLATVLLGRSNFANWSFAIYPLKVFKVMHIDDFEEESTLILDVKSEYNILNENKAVVLASFDLADKYFEFSRNLQSLPMSVIALVYSRITHPSVWHRRTLDKILILGNLLYKECVECKNVLELKLENLPALFTIGPYIVEIYIFGNVFADLMYRSCVCPLKKCFEQFFGKCTNAILQIGTCHMAIWKQRNMLYCFDPYSRNSEGYAQARGVACVSMHSTLDSLIDLIATNYDKDAVFYIHALKVCKIHRDPCQAGRFPRHLSMDDFPVDTFKKYKIKKSKKNATEKPITVDYSAIAMRRLLMEESPRGSIVEIGSTVGSIAMDQLGLPPYQKRVPSLILKPAFKKKAMEEVIADLDSPSLEDTQIEPPLPQQTSEEIEFMDLDDFEMTMEEKEMEEPPAEGEDGSAGKRFAHEGEDESERKKAQLEKELLEEPEEWYYATDKSLQKDMTMEPSRVSMEINTELTYFPIKKEILYPTYIRGKQQMKYRLQKYKFTEEDWENYLPPSPPDLTQSEELKKDTNFIDLPDDTQIILGSKNVAHLGKTVEYIAPFVCIMANVVAKKYSIISWTGEIVDYILRCGNELYSASKFRYDQVSKLEIPRITLGNNAYSVLVEYIFDSYIRQNILALALDKILFVRSDTGVLVTPSYACAVMHKNYLYYLFDPFGNNEVGLSEGPSQKGVTCCARFKDLHSLTMRILYNKRKRESAEEVAYSRFVLSSVKVKEIINFAERGKPKKKKDKHKTVSSDEEGEGQISEYYVEEAEEEMEKEEKEEFPENKVGYHYQAGHCTILGTKALPNRKAVSADLKEDHFICVCACLLLLTTPVTRWDTRKVDLAIDYGVHVYSHADDLLISEKRTIKNILVGKHFFDIIIKLIKIEDWRQNRNLSKGIDYLLAKKLSYFMVQFANASYVIHKTQDEKFHIFDPYGQPKNQPAGWLKCRDIRELKWQLKKKILRDAKSYNFYTFEVTSITKAPKDLVISHELQTYDMITEARKEKQNVPFYEDVEWLKVDPIAWSRKNVQAPNGKTRGTPENLWHNWDEEYPKDLYSLMGNVNELSTRFSSKTRAKQTLANLVTAIGMTKIYELEEWNAAVVDSVLVNGDNYFRECMENISEEDYELTIDDLNADCSIFPFSFKVTFNPIVEGTMFLVRPTQYNLYKALWYFFNNFTNRCGIIFVTRQQSKRQVAFGKLRESEYFMFDSSCRGSPMFLQGTGVAYILRMTTLNRLLHVLTLTLRGGDFYIYEVEVADLKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IRD9</accession>
    <name>A0ABM5IRD9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor, arginine/serine-rich 15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028139604.2">
        <property type="nucleotide sequence ID" value="XM_028283803.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283803.2">
        <property type="protein sequence ID" value="XP_028139604.2"/>
        <property type="gene ID" value="LOC114333801"/>
    </dbReference>
    <dbReference type="GeneID" id="114333801"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16983">
        <property type="entry name" value="CID_SCAF8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12227">
        <property type="entry name" value="RRM_SCAF4_SCAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF4">
        <property type="entry name" value="PROTEIN CBR-NRD-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="469"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="919"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1113"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1178"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1264"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1382"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1403"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139604.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1456" mass="165552" checksum="F1E38D9C6E159FAC" modified="2025-10-08" version="1">MDAVKSFNQELSSLYEVKPPISKAKMTALTRGAIKAIKFYKHVVQSVEKFILKCKPEYKVPGLYVIDSIVRQSRHQFGSDKDVFAPRFSKNMQQTFVNLFKCPAEDKSKIIRVLNLWQKNSVFPPEVIQPLFDLADPNNPIHKEIENAMQQSTNGLNSTTSSIIKGSPALQKTPTKGSQQGNDLHGTTSLNLADPSVLQQLQQLQRLISKNVENSVRTEPVHFDKKLLDFDYGDDDDDVHPSPRPPQPSADPFLPVTSLLTNPEVLRQLQTLQQTMANAVQPQELDMDRARKMQEMKQQEEEFDKHLAQTVPNLPFAAECDFRSNQNHLMVQNNYFLEGMNPPAPQYHPDFEQASSQGMTDKSHQPSNAEVEVITLDHDDSRSPSPAEDRYRKRRRSRSRSRDRGRRDRRRSRSRSGSRRHRSRSRDKDRKKEKEKTKEEKEKETEKERERKKRGLPSIKKDHLSVCSTTLWVGHLSKLVHQDDLSNTFGEFGDVVSIDLIPPRGCAFIVMLRRQDAARCLTKLKGHNLHGKSITLAWAPGKGVKGKDLKDYWEGDLGVSYVPYSKLKQDIDIDLLEDGGMIDEETMPQWMKEKVDKGKKPELDLTGFVGGSTPNIDTSQPPPLPGAGLLQPPPMLPTFNPFQLNNRFLGMNVPPGMMPNMANMPNIPIGVPPPNMAGAPMMGNQLLGLGSAFQGPPSMIPPQMPPVENKPPTLPSDANLHSLGESLMSLTQSFGVVPQPPAPHEDTMDVEMEDADSKPLDKPGRDEHSNKSNNRDDDRRDSRRDDRDRRNRSRDRDRDNRDRDRDRSRDRHSRDRDRDRDRDRRYRNDRDSSRGRDRDRRDDRRDRDRDRSNRWGDRDRRDKDSERDDRRDREKTLNDRLREMAGMGGGGYDDRDRRGDRFNRDRDQGFKFMPPRANSRSDEDYGRDREGRQRDRFDRNENSRQRNDSNDRNDRKRNNDKPVHEEREVTKVDEKQILEEQATKEKETGSGQNIEGNSPSDDEVPPGTEDGAEGSERASERMEDTKDRPEAEEHSQETLRFEAPPSFNAAPPMFDHPPPFTGPPPFDGPPGAFDGPMGMFDDRRGPPRGYFESGPPMFNDMRGRGRGRGRGGPMMPMGMNMEGPPMMEGPYNDRFMRGGRRGGLRGPPPGDFFPGDDFRRGRGRGRGQFFRGRGRGGFNSRFDGPPFDGPYDGPPFDGPFDGPPFDGPQFDGPPFDGPPFDGPQFDGPQFDGPPFDGPQFDGPPFEDMPFEGRPRFDGPAGRFNRGEPPRPWGRPERPEREGREGRRSRWGNDSPRFEGGDGRHGEYNDVPPGVDPGLESRKWNIRVKGEQEMQGPEMMENNNDMDDNEQGGHQGREDHEGEEDEREVGDEAYEQAQREYEEGGDCEEDGGGGEDEYEQEAGQQHHQEDYTEDRANTPVEDEMAHPGDSEEQFEEAEQGDAPEAEEGGAEEADAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IVI6</accession>
    <name>A0ABM5IVI6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143751.2">
        <property type="nucleotide sequence ID" value="XM_028287950.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287950.2">
        <property type="protein sequence ID" value="XP_028143751.2"/>
        <property type="gene ID" value="LOC114337497"/>
    </dbReference>
    <dbReference type="GeneID" id="114337497"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF96">
        <property type="entry name" value="FACILITATED TREHALOSE TRANSPORTER TRET1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="130"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143751.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="586" mass="64810" checksum="B0A1BAF0AE9D92A8" modified="2025-10-08" version="1">MSHLSTSISKQMRPGLTVVSKVAPSSSQNPRQGWSFINPGTWTQWNGNHRRLQNTESPCISTSTTATNLSCLADSNSAINQKKMNKDANIRVAAQEIEPLQKVKVEAPVPEEEEEPFDLTFKNIKTQLFAAIAVSWVSLIIGYSTAYTAPAEYSLRRDFGFNDNEISWISSFMPLGALLGGLGGGTLIEFIGRKWSIMLTNVCFLVSWLLCYCASSYLYLYIGRIIIGLSVGVASLTLPVYTAESLQPEVRGSLGLLPTGLGNLGVLICFTLGAFYEWQVLALVGALVSIPFLVMIWFIPETPKFLLGKGKLDKAKSSLQWLRGKNSDIGKEFTDLQRIQQESNELNATLLDLFSKKNMKLIVVALGLMFFQQFSGINAVIFYTTTIFEYAGSSLDKKYCTIIVGVVNFGSSFIAAMLIDRLGRKVLLYISSISMIVSLNVLGIYFYLKDVAHTDISAIGWLPLVSFMVYVLGFSLGYGPIPWLMMGEIFPAKIRGPAASLATAFNWTCTFIVTKTFLLIRDGIGTHYTFWMYGIIVTLSLFFVFVFVPETRGISLADIERRLTGIRTTRRISSVANLKPLPSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IY71</accession>
    <name>A0ABM5IY71_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148767.2">
        <property type="nucleotide sequence ID" value="XM_028292966.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292966.2">
        <property type="protein sequence ID" value="XP_028148767.2"/>
        <property type="gene ID" value="LOC114342177"/>
    </dbReference>
    <dbReference type="GeneID" id="114342177"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="588"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="767" mass="86881" checksum="687811A371C06EE1" modified="2025-10-08" version="1">MSSTSKCIVKITNDGLEEILDESVSLNLDLIEESTNPVPDEVLPVVLNLAELPDEDSLDNNLVNKVSISDVPSEELNKPASNKDKRTEAADKGRPVVLNKVSQQPNKKNGARETNNKKLAFNSKGFQPSKKQNGARESKKAKLSFNGAGNVQEKFPSTGFWNQKKLKGAKRGERSYSTRETEGRIRSHVLREEKRETMAESFSRNYNSYNSGPDNRKPETMAESFSRNYNSYSGPDNRKLETMAEAFARKNYPNSAVDKRKPETMAEAFAKKNYPNSAVDKRKPETMAEAFARKNNPSNPATHSGKPSRGRDIDEGRRESDIPRRRSPYGHDRASHSYRDHVSRERNTVASERRPFTSERNEVYRETRGRSPFGRERSPLHRETFGGGSFVNERSQFHRENREMNPFGSERSQLHIETGRGNSSTSDRPQLYRETLGINPFTSQGNPFTNQGSQLCPGTFGQSSFAGVNPFTSGGNQWHHGNQERNSFSSGTMHVENQGRNPFPNGTMHGQNQGRNPFTSGIMHGGTQGRNPFNNEISTFSSNTNQFHGDSIPFNDDRDSEEESEKSEDFAGPVEQKCSKFMKIYDDPERKTLIVPRAYPKIRFSKFEITILKALILTHMSTVNVKSNAKLEIEGTVSHKGALLVTCRDQHTKQWLDKLVPQLKRQNGENMRVALLKELLWPGIRVTMFLPGKFRRSPHGYLVQLAQDNPGLVTKHWCIRGKNKKKNTILLKINEADVMVLRKYNMRPKIGTCEIVFELATSKRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZH3</accession>
    <name>A0ABM5IZH3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028152430.2">
        <property type="nucleotide sequence ID" value="XM_028296629.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296629.2">
        <property type="protein sequence ID" value="XP_028152430.2"/>
        <property type="gene ID" value="LOC114345829"/>
    </dbReference>
    <dbReference type="GeneID" id="114345829"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF238">
        <property type="entry name" value="CUTICULAR PROTEIN 65EA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045390992" evidence="3">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152430.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="240" mass="27812" checksum="200050D6B89DE7A9" modified="2025-10-08" version="1">MIKLFLLAALGVVATFAAPQVVSSTAAPVAANDYYRNNYFGNNYDPYYRQGNNYDPYYRNGNYRNNYYRNQYDPYRRNNYYDNDYYRNNHRNNYYNNDYYNKNNYYNNDYYKNNQYNKNVYNTEYRKNYVAGSEANARILRFESNYNPEGGYEYAYETDNGIAAQQQGFPIAPPDSPPSIGVTGFFSYTSPEGQQVYTRYTADENGYRVEDNGLQGGAVVRQGVVPVNAVVESSTAASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IZZ7</accession>
    <name>A0ABM5IZZ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
            <ecNumber evidence="6">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes juvenile hormone hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin</text>
            <dbReference type="Rhea" id="RHEA:23900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:50004"/>
            <dbReference type="ChEBI" id="CHEBI:50014"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.9" evidence="6"/>
    <dbReference type="RefSeq" id="XP_028154667.2">
        <property type="nucleotide sequence ID" value="XM_028298866.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298866.2">
        <property type="protein sequence ID" value="XP_028154667.2"/>
        <property type="gene ID" value="LOC114348266"/>
    </dbReference>
    <dbReference type="GeneID" id="114348266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="7">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154667.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="454" mass="52975" checksum="D17F0C22819835A7" modified="2025-10-08" version="1">MVASSIKVSLFIIILSTVVFFVHRFLYTVPPIPEYEEKWWGSGEPKKVDDSIRQFKVNMSQEDLQDLNYRLKHTLPFQRPLEGVKQHYGMNTNLLQKVTEFWRTKYNWKERETFFNQYPHYLVNIQGLDIHFVHIKPKVPKSIEVLPMIMLHGWAGSIREFYDIVPLLTTPQEGRDFVFELIIPSLPGFGFSEATNKPGLGAFHMSVILKNLMLKIGHQRFYLHGTDWGSVIAQHMSVLFPEHIIAFHSNFCVIDTALSNLKLLIYSLYPSLFVDKVEEEIMFPLSKRYNYFLVESGYFHIQATKPDTIGVALRESPTGLAAYLLEKFVTLTNTTYKDLEDGGLTEKFTYTQLLDNIMVYWMSRSITTSMRIYAELFHEDNRAKLRIESIPIKVPTGCARFRYEVMFFCEDILREKYPNLIHLTYYDGGHFPALEQPSVLAKDIYTFIEKTFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JID4</accession>
    <name>A0ABM5JID4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497695.1">
        <property type="nucleotide sequence ID" value="XM_050641738.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641738.1">
        <property type="protein sequence ID" value="XP_050497695.1"/>
        <property type="gene ID" value="LOC126878831"/>
    </dbReference>
    <dbReference type="GeneID" id="126878831"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="199" mass="23722" checksum="107442866C18C058" modified="2025-10-08" version="1">MPSCAYPLCDYNAGNKKKFSSKVTLHGFPKDVKRREAWIQFVNKENWEPRKGSKLCTRHFEERHVDRTSLAHPIRLRENAIPTIGESQVLQMQENSKVRILSNISIMSERNVISNVSPDIPSTSCELTPRKWKISKELGRSQKISSERKRRLRNVRRRLQRSEKQRSWFIWIYCFIWIFILFKLLIFVDVIVFIFKHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJP8</accession>
    <name>A0ABM5JJP8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498164.1">
        <property type="nucleotide sequence ID" value="XM_050642207.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642207.1">
        <property type="protein sequence ID" value="XP_050498164.1"/>
        <property type="gene ID" value="LOC126879173"/>
    </dbReference>
    <dbReference type="GeneID" id="126879173"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="362" mass="40208" checksum="8BF0C8AA72C4C50B" modified="2025-10-08" version="1">MSNSVSNLVCVNDYEEYAKEKLKNGSFDFYNGGAGQQRTLEWNKTDFSKYRIRPKYMRNVSNRNLSTNILGKPVAVPIGISPSAFQKIAHPDGECATAKAAQESDTILILSSHSNCTFEEVAKAAPHGRKWLQLYIFRSREITKDFVKEAEKNGFEALVVTVDFALYGIHLGDLRSQFKTPPHLESINFKKYRDGDNTINFVDFTDPEVEWSYITWLKTITNLPIVVKGVLTGEDAIAAADAGASAILVSNHGGRQLDSLPSAIEALPEVSKAVGHRIEVYMDGGIRDGTDVYKALGLGARMVFIGRPALWGLTHDGEKGVKKILEILKKELDNAMGITGCSKLTDINQDRVVHESYYARQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJX0</accession>
    <name>A0ABM5JJX0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498237.1">
        <property type="nucleotide sequence ID" value="XM_050642280.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642280.1">
        <property type="protein sequence ID" value="XP_050498237.1"/>
        <property type="gene ID" value="LOC126879223"/>
    </dbReference>
    <dbReference type="GeneID" id="126879223"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047040473" evidence="2">
        <location>
            <begin position="18"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="592" mass="67434" checksum="21706CA084A5ADA4" modified="2025-10-08" version="1">MKIILLILLAICTILSAAEYPRYKGRPPPPRQRRVPTNQQFSKKWHQGGPLIQNLPQGIPQGFPQGMQGVPPGHGQFGLRGPPLRQRPVNHIPVLMVPNNVPQIKHHKIPQPNGLGHQLPQRQATLPVRSFWKNPVAPVKLQQEVVFKTPLPTPPPEKPFRSAPSIPTSQEFDYHIQTNQIPTAHINPIKQIGEKGPIHTIPAPNLSLKDKPLHIEEVRNDISFPHPSHHNAHLSTQVTIQKSHEYQVTEPPEHNQKLFRAQQEHQKQIQRQIQKQIQQMHQQTVQQELLNQQQQELHEHQQELHHQQQQELHNHQQQELHNQQQFLLATDQSSVHQTLEPNPQGDIILSNNLSPKDLYQLVSANYPQLQIPKATSNANVQLFSPDPGFLEQFPQESIQIASDKISFQPEYHSFNYDEQAHQKSLAKKDMSSLVSATYNLGGDKISSRNSVDPLAQAEIVQSYFDSRSDVADNNIEADAKSNTKKDIVDEKLIETTFYSSLPSKEAAERLAQLQTAGKVNSNLMKLSPTKKDTNEPLTIVISDEYEGEEETIKGSRKDESKEESRDYDEYSHEENIASEEFGHRIQPKKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JKU5</accession>
    <name>A0ABM5JKU5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498562.1">
        <property type="nucleotide sequence ID" value="XM_050642605.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642605.1">
        <property type="protein sequence ID" value="XP_050498562.1"/>
        <property type="gene ID" value="LOC114330093"/>
    </dbReference>
    <dbReference type="GeneID" id="114330093"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="363" mass="43004" checksum="90ED20DB6CD674FB" modified="2025-10-08" version="1">MAPTPTYIESVANNNNNNESESKVKLFPYKIQPIEENLRKKLLAVFTGEKTKYLQVGPKKWLYPSGYEKQAHDFYNFVARPSDVFIVTFPRSGTTWTQEMIWLLANNLNYEKASQVNLRQRFPFLEFSSFLHPEMKAILLKENQHDWEKCQIIQGLDRGIIENLNNMKERRFIKTHNPFSLMPPNLLDVGCKVIYVARNPKDVAVSYYHLAKTYRTFCYVGDFPQFWRYFQDGLVPWAPYWEHLKEGWNRRHEENMLFLFYEDLKKNLRPSLKKLSSFLDQSYSEEEYEILEDYLSIDNFRNNKAVNADEDKDIGLISDVEAGFIRKGVVGGWSPYFDDELNAEADRWIEENLKTFDLRFPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JML9</accession>
    <name>A0ABM5JML9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050499186.1">
        <property type="nucleotide sequence ID" value="XM_050643229.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643229.1">
        <property type="protein sequence ID" value="XP_050499186.1"/>
        <property type="gene ID" value="LOC126879887"/>
    </dbReference>
    <dbReference type="GeneID" id="126879887"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF69">
        <property type="entry name" value="GH07286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="4">
        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="545" mass="60860" checksum="F7E40F0F181FE29E" modified="2025-10-08" version="1">MFKLTNVFQKSCSRSNGLVPFIRFNFASSSSPQLKKTNTESEDVSEKAENRKRLVRAPQPHKSMVAAAFASLNSEEVNSAIKTPQTDGKLSKATNIEELLSVSEGTGVSRRHALKVVSILSEWSSTGKVTISEFENDPRFIKLCHILTKSNISIKNIKTNSRSEDLSTVLSVTADDEAAKMVANITLPQMVKVMSTLSLKKRRSTLLLRSLSYNITRSTDQLNLKQCSDLLFSMATLNFLDDNLLSRVAGDITVELEKNIKRSSVIGSILTSIGLLKYKNPALLDILSEWILGNQSICRPQDVFSLLMTLAVVNYKPNNSENLFKVLLPQLTLSEAGKPQVWLDIVWSLTLLNKANSSHVSSVLDKSFLDQLEEPLSFSTKLKLLNIDGAAQYLLNNYDGPRLPSDSEVKKLDVPQAKDKTEMVTSILDTLKNLIQSDQLIRTRVNTEYGFCIDAECVLDKKCSPLPLDQAKINEDATRVAILAFDYHDMCRGKVEPTGVNNFAIRVLEAQGYKILTIPFTEFRARDKLVNRVQYIESKLKETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JPR3</accession>
    <name>A0ABM5JPR3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499928.1">
        <property type="nucleotide sequence ID" value="XM_050643971.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643971.1">
        <property type="protein sequence ID" value="XP_050499928.1"/>
        <property type="gene ID" value="LOC126880193"/>
    </dbReference>
    <dbReference type="GeneID" id="126880193"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01268">
        <property type="entry name" value="PTB_Numb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010449">
        <property type="entry name" value="Numb_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF2">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06311">
        <property type="entry name" value="NumbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017607">
        <property type="entry name" value="Numb/numb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="72"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="492" mass="54686" checksum="541E958E1D59E6A4" modified="2025-10-08" version="1">MGNHPSNHVPLERNISKFGDVNARRSLRSPRKMDRLRRSFRDSFRKRKDRIPESSKPHQWQADETAVRSGTCTFAVKYLGCVEVFDSRGMQVCEEALKVLRGSRRRPVRAVLHVSGDGLRVVEEETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLALRESGERLSHAVGCAFSVCLERKQKRDKECGVTMMFDAKNNTFTRSGSFRQQSLTERLDRERGIDVGPTNSKPQPPVNPFAIERPHATPSMLQRQGSCRGFSTLGESSPFKRQMSLRVNDLPSNTARLNSYKSPTSPTANGKPPVSPIPEVSPGDSVTALCQQLSQGLSQLTHSGSDDFNFNNQSSVNQNTLNVNVTTINNSFSRASPNVFTPVNLNFSPKNEVNTSTSSTSTLPKPEQWLEMVKSSSPTLGKVDGSTPRRTPSFKAQSRAVSLDTGSDSFQSTRADPFDAEWAEMAARQGTNSTNPFLTSSTTPKAFQIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRJ1</accession>
    <name>A0ABM5JRJ1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger MYM-type protein 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500562.1">
        <property type="nucleotide sequence ID" value="XM_050644605.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644605.1">
        <property type="protein sequence ID" value="XP_050500562.1"/>
        <property type="gene ID" value="LOC114333658"/>
    </dbReference>
    <dbReference type="GeneID" id="114333658"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF28">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="80539" checksum="25B80F99C7342475" modified="2025-10-08" version="1">MSVVQNIMLLKIANKLTYEELLNFKAAGRPKPTMPIKQTTLDKTREVNRYFSASMYNVSEWICGCEVQKAFFCFPCLLFGDDYSWTKAGVVDLKHLKEKSQKHSLLSAHINSCCSLAMLGSVVIKLLSDNEYNQGFKTYNENVSKNRFVLNKMIDCILFCGAFELDRRDKQNRREPSDSQTIFGGLIDFVSEVDIIFKENFKNSAIFKDSSNDIKNGLLDSILAVIQGEIRSEILQADFVAIQADTITDNNKVAIILRYVKDDVVCERFYTLIQSKGIDIEYLSAVILQELQQMKLNEHPEKLVGQSYDAASVRSGGMGGVQAKIKSFCYTSAHFIHSYAHPLNLILQKAASQDRAVKVFFANLESFSSFFGKSPERTAVLDEIVKIGLIKEVPTYWDFNTKVIETVYTNKSELIDCIDKIIDSETNNSSINQAMSLKNYLEDENFLYWLNFFHAVMPHCDVLFDVLQKRDLDIVTIDKCIMNFRNKIQAIKCNIMTNCEVCELENSLKRRKIEDSKRRISLEVCNIIICEIEHRFGRSNYLILSQLFYSDKFICYRQDFPENIFKLVKTEYPVINHSKLKTELEVVYSREDFNNYEGATSFLQFFINHNSWGAFSESVKLLKILCAIPMKTDETGRCFLTSQRIKTFFGKTMSQERMCAWAMLSIEKNFVKNIKDFNEKVIDHLASQNTSGIDLVYKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JS74</accession>
    <name>A0ABM5JS74_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500793.1">
        <property type="nucleotide sequence ID" value="XM_050644836.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500842.1">
        <property type="nucleotide sequence ID" value="XM_050644885.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644836.1">
        <property type="protein sequence ID" value="XP_050500793.1"/>
        <property type="gene ID" value="LOC126880781"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644885.1">
        <property type="protein sequence ID" value="XP_050500842.1"/>
        <property type="gene ID" value="LOC126880820"/>
    </dbReference>
    <dbReference type="GeneID" id="126880781"/>
    <dbReference type="GeneID" id="126880820"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="104"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="311" mass="35921" checksum="8112E137E7CCE727" modified="2025-10-08" version="1">MARLAAHPDEIYELLDEIDSDLEIELEDDDDDWVPSEEENLCVQDDEIEESDKSDESGDENDSAVPSTVQNLQKSSMLNWGRTNPFKNENIPETILPDPTEVLTPWCYFEKYLGNSFFQLCAERTAQFYLQKHGRELKPKVTPEEIKKFFGIHAVMGCLKFPRIHLYWSSRFKLPVIADAIPRDRLYLLRVNLHIVDVCTVTEEIKKNNRLRRVQPMIDLVRSRCRELKRESEAAFSIDEQMIPFLGRCALRQYVKNKPRPVGLKNFVLSKSDGTVLDFEIYQGTSTNLRNKELGLGPSVILRLVETLPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSL6</accession>
    <name>A0ABM5JSL6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500931.1">
        <property type="nucleotide sequence ID" value="XM_050644974.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644974.1">
        <property type="protein sequence ID" value="XP_050500931.1"/>
        <property type="gene ID" value="LOC126880900"/>
    </dbReference>
    <dbReference type="GeneID" id="126880900"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1274" mass="148049" checksum="25DDBF65F5290304" modified="2025-10-08" version="1">MLAKLIQLIATILGLIKNDYNAEKLRQGLIECNKASKKLRDSMRYAKTIGEKQHLEAQMRQVKTLRNQLKAEQKKGAGLNSRPETAYKRVQWDDSISAFNSRIRTGVISNLKHKDPSSFLVDCKALFKRRIQNALKTDEAVKVNMAFGGEFEVASGDMILNETKYFTTSNSPIYKDTNLDEWFEKKVVEPISRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIELPPQIKRKKACINVKNDDEACFAWAVISALYPCQTNSALMSSYPHYSSILKLKGIQWPMTIKQIPNFEKQNNISINVYILKKEKNSTILPTFLTKNKKDKHVNLLLVQDKYDEQGPIRYHYVWIKNLSRLLSKQLSNENGTKYFCDACLHYFRSQEKLNFHKTCCKGRSDVICDRCLQPFSSSAHLEAHTDDCERMNETAIKMPEESRKMLRFKNFRNKIKAPFAVYADLESALKRTGDPEKHQEHIPVAVGYFFKCSYDDTLSFYSSYRGKDCMKWFADELNQLAEKVSTVFMCPYDINMTSQQESDFHAATHCHICEQRFSLDDKKVRDHDHLTPDNNYRGAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVNDIATHIKGPVDLDDARIRFRFVDSFRFMASSLDKLSSYLTEYPNLRSQYTSLPEENFHLLTKKGIMPYDYIDSFTKFSETSLPPIESFYNKLEDRPCPRRHYRRAQDVWSSFSCSTLGDYIDLYMKTDILLLADVFEQFRSSCLKTYNLDPAHYFTLPGFTWDAMLKHTKQELELLTDPDMFLFVERGIRGGLSQVCSKRRVHANNKYMASYDPSKPDSYLIYFDVNNQYGWAMSQFLPYGGFEWVDVNIDVLSIHDDASEGYFLEVDLVYPQHIHDRHKDLPFCPQSLNPKTMLPPKRPREQTKLMATLHDKERYVIYYRALKQALAHGLLLKKIHRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTMENVRKRVDIKLLTEWEGRYGAEARISSPLFKNATIFNENLVAVEMHRAEIWLDKPIYVGMSILDLAKTTIYDFHYGYLDRRFGENFTTCYTDTDSVIVEIREKDPYEAMKTDCHQHFDTSDYPKDNIYGIPQVNKKVLGMMKDENNGCIMTDYIGLRSKLYTTKVAITDNDIKKLRGNLIDQEYEDDEIEILIKNYGVTKKAKGVKKSVVNTKITFEDYVECLDTFTTKAASQNLIRSDKHHVYTITQSKIALSPNDDKRYHLPESYDTLPWGHYLIDNLEMYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSU7</accession>
    <name>A0ABM5JSU7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501018.1">
        <property type="nucleotide sequence ID" value="XM_050645061.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645061.1">
        <property type="protein sequence ID" value="XP_050501018.1"/>
        <property type="gene ID" value="LOC126880978"/>
    </dbReference>
    <dbReference type="GeneID" id="126880978"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="36"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="280" mass="31681" checksum="32AAE063BCAFE60F" modified="2025-10-08" version="1">MVCNFYFQMTKTNESWYFIAKQFNDKWNFPNCVGAMDGKHISIQAPINSGTDFFNYKSFFSIVLFAVVDANYNFIYANVGCQGRISDGGVFNDSYFKECLEENTLNLPPACSLLGRSTDVPFVFVADDAFPLSTNIMKPFAGHQEKGSKNRIFNYRLSRARRVSENAFGILSAVFRVLRRPMLLEPETATNVVLALIHLHNFLRKNTSRNLYTPPGMIDVECSDTGAINPGLWKRNASSNELFSFGRRARRSGAAAQNVRNELAEFFISQEGALPFQYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JSY5</accession>
    <name>A0ABM5JSY5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA/RNA non-specific endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501052.1">
        <property type="nucleotide sequence ID" value="XM_050645095.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645095.1">
        <property type="protein sequence ID" value="XP_050501052.1"/>
        <property type="gene ID" value="LOC114342722"/>
    </dbReference>
    <dbReference type="GeneID" id="114342722"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045978876" description="DNA/RNA non-specific endonuclease domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="403"/>
        </location>
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    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="5">
        <location>
            <begin position="140"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="6">
        <location>
            <begin position="143"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00477"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00892"/>
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    </evidence>
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            <dbReference type="EnsemblMetazoa" id="XP_050501052.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45437" checksum="D1D3FC59D8C127F4" modified="2025-10-08" version="1">MVVMCNCVVLVGVTSILLYLVALIHADCQIDPFDGKAPLVLTAKDSSIVYPNSGETTLDFRNGEIVTFACSGNNIFLSGLMHQTTVEGRCLANSQFDVFGKRYSWTDIACSSNPRATIRKTNSHCARDATMVVVGYDLGNGNFASIIDICFNTSSQIALYSRYDITSSIQSNDETFSRPAFFEDSNLYNIKGRVDTYYKQNRQRTTINNLLGLSPTSSKYISSGDLFLSRGHLAAKTDFLYGFQQDATFRYINVAPQWQSFNGGNWNRVERSCRNYADRRKANLQIWTGTYGIATLPHEFTQKPTELYLYVNGRTKALPVPALYWKIVYNPSNFRCVVLIGLNNPFEDNVSRYIICRDISNSLNWISWQKNDHKKGYSYACTCNDFKSRVDYAPSLKVSGILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVN5</accession>
    <name>A0ABM5JVN5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502008.1">
        <property type="nucleotide sequence ID" value="XM_050646051.1"/>
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        <property type="protein sequence ID" value="XP_050502008.1"/>
        <property type="gene ID" value="LOC126881662"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="CenT-Element_Derived"/>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
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        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="241" mass="27296" checksum="4D373F8079A4212E" modified="2025-10-08" version="1">MSYKKYSEDVIKLAIQEVREGNSIKSTAKKHNISRPILQRRLRTDVFVATRMGPPTVFSLDQELVFVRWIKEMANKGFPVTKDTFMFSVAKTAKELNIIFGDGSSDPGRKWYEGFMKRHPDVSTRTSQNLTVQRRAATQAEIEKWFQEVQQYVSDNNLREALEDPKRVFNCDETAFYLNPKPGKVLAAKGSKSVYTASGGDEKLNLTVLLTANAAGELAPPMIVYRYVRLPQLIVSAMPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYB9</accession>
    <name>A0ABM5JYB9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050646981.1"/>
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        <property type="protein sequence ID" value="XP_050502938.1"/>
        <property type="gene ID" value="LOC126882131"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35450:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="384" mass="44253" checksum="6807B8498D39EDF5" modified="2025-10-08" version="1">MAEEPKRMVWMQLKTTIIIIIIIIIIIRTHLTKAQKHHPKSAVERTTLPRYLGGRGLMDIGEQLDKQIANLRTYFQMQAETSTLHRAICAADDTTPIKLREPEMRLIHLTKDEKLRAWMGKPLHGRHPNEVSQDYVDNTASNYWLTSGKMFPETEGSLLAIQDQVIPTRNYLKYIVKDPQVQNDRCRYGCQAQETIQHITGGCQAFAATEYKERHDAVGKILHQEIANKLGLLQTDHLPYYQYVPESMLEDGNYKLYWDRSVLTDQTVAHNRPDLVLVNKLTRQTTLIDVAIPNNNNLRSKFTEKIAKYRDLEIQIRRQWRMQSTQTIPIVISTTGVIPKTLLESIKKLGLNEHLYKTMQKAVLLATARSVRKFLGDTPAFQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZA4</accession>
    <name>A0ABM5JZA4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_050647311.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647311.1">
        <property type="protein sequence ID" value="XP_050503268.1"/>
        <property type="gene ID" value="LOC126882395"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="458"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
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            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="787" mass="92231" checksum="C1D6C06245510985" modified="2025-10-08" version="1">MEVKQEISEETCKLEIEYNDLDDALLDGFKCEVKEECNRQSTHDTNDYLDLKEHPKHTEIGQHGNKLDPFEENQAKGYLQDEHKMEIMGTLIDSSYDGNYTTQQAEGKTNQNMKGLTGQRPYKCNICSKQFSQTSHLKAHLRIHTGEKPYKCEICFKQFVQSNDLKRHLRAHTGEKLYKCEICFKQFNQTSHLKTHLRVHTGERPHKCEICFKQFTLASHLKPHLRVHTGEKPHKCEICFKQFSEGTHLKKHLRVHTGEKPYKCEICLKQFSGADKLKNHLRIHTGEKPYKCEICFKQFSEATNLKRHLRVHTGEKLYKCEICFKQFSQASSLKTHLRVHTGEKLHKCEICFKQFSEASSLKTHLRVHSGEKPLKCEICFMQFTEATKLKRHLRVHTGEKPHKCEICFKQFSEASSLKKHLRVHTGEKPYKCEICLKQFSRVDKLKNHLRIHTGEKPYKCEICLKQFSGADKLKNHLRIHTGEKPYKCEICFKQFSEATNLKRHLRVHTGEKLYKCEICFKQFSQASSLKTHLRVHTGEKLHKCEICFKQFSEASSLKTHLRVHSGEKPLKCEICFMQFTEATKLKRHLRVHTGEKPHKCEICFKQFSEASSLKKHLRVHTGEKPYKCEICLKQFSRVDKLKNHLRIHTGEKPYKCEICFKQFSEATNLKRHLRVHTGEKLYKCEICFKQFSEASNLKTHLRVHTGEKPHKCEICSKQFSHAINMKTHLRVHTGDKPHKCEICFKQFSEAGSLKKHLKVHTGPYKCKICFKQFSHNHTLKGHLKVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JZV1</accession>
    <name>A0ABM5JZV1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050503466.1">
        <property type="nucleotide sequence ID" value="XM_050647509.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647509.1">
        <property type="protein sequence ID" value="XP_050503466.1"/>
        <property type="gene ID" value="LOC126882541"/>
    </dbReference>
    <dbReference type="GeneID" id="126882541"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="152" mass="17115" checksum="EED20D00CE15EFEA" modified="2025-10-08" version="1">MTNFIKQHLPEEVKVIIVGQDPNDAGATGLAFSKDVGAGIYQSTAIILEEVRNDIGENNLRPFPRDYGNLDYWAKQGVLLLNSALTKPTNKDESHANLGWDEIVGELIKRLQQINKNIIIMFWGLLARELSEYVELYDQNQLLFAGLPTMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K012</accession>
    <name>A0ABM5K012_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503526.1">
        <property type="nucleotide sequence ID" value="XM_050647569.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647569.1">
        <property type="protein sequence ID" value="XP_050503526.1"/>
        <property type="gene ID" value="LOC126882596"/>
    </dbReference>
    <dbReference type="GeneID" id="126882596"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="316" mass="36404" checksum="76445A5FF211A42C" modified="2025-10-08" version="1">MPDIQPMIVGIFHGNNKPLDIKEFLEPFVEDVKRLQSNGLCVNGHMIHIKIRCFICDSPARAFIKGVVNFNGINGCLKCTTEGEYSYLSRTVVFPDIKCPLRTDAKFRSKHYGKHHKGQESPILKISEVDMVQDFIVADELHLLELGVMKRCLTGWKDGSMGFSSKLCARDIERISKHLISVKLPSEIHRSTRGLDCLAYWKGVEWRNFLIYIGIVILKDVLNTDVYKHFLLLFVAVRICSSDMYAENRSVAQLMFEKYIDDFKIIYGVQLITSNIYNLEHVVDDVNRFGQLFTISTYHFENTLFQLKKLLRQGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0F8</accession>
    <name>A0ABM5K0F8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050503676.1">
        <property type="nucleotide sequence ID" value="XM_050647719.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647719.1">
        <property type="protein sequence ID" value="XP_050503676.1"/>
        <property type="gene ID" value="LOC126882731"/>
    </dbReference>
    <dbReference type="GeneID" id="126882731"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="138" mass="15134" checksum="0B0C8A550707C8E3" modified="2025-10-08" version="1">MPSLCKLTIADLRLELEERDLSSTGKKADLVERLKNALKKEGHDPETYVFEDKHAALISSITSLESKVSSEISQVSSDVLNVLGTRQKSMQMCAGIAATEDDVSPVIHMRAKVLSAMYLAEVWTPKVSGMSRIATLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K0N4</accession>
    <name>A0ABM5K0N4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vicilin-like seed storage protein At2g18540</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503750.1">
        <property type="nucleotide sequence ID" value="XM_050647793.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647793.1">
        <property type="protein sequence ID" value="XP_050503750.1"/>
        <property type="gene ID" value="LOC126882774"/>
    </dbReference>
    <dbReference type="GeneID" id="126882774"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="21118" checksum="C56994910300C6D8" modified="2025-10-08" version="1">MVNTRSSKVEKEMDTSGPPAWFLKMKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKENEEKRRQEEKEEDKKLRKEEEERRRQAEVEIMNSLSQIHEHFQLELLMSNPNKQPFPLPSLIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K274</accession>
    <name>A0ABM5K274_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504290.1">
        <property type="nucleotide sequence ID" value="XM_050648333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504291.1">
        <property type="nucleotide sequence ID" value="XM_050648334.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648333.1">
        <property type="protein sequence ID" value="XP_050504290.1"/>
        <property type="gene ID" value="LOC126883096"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648334.1">
        <property type="protein sequence ID" value="XP_050504291.1"/>
        <property type="gene ID" value="LOC126883096"/>
    </dbReference>
    <dbReference type="GeneID" id="126883096"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="115" mass="12948" checksum="287CAD71193557BD" modified="2025-10-08" version="1">MEQHTIICRTCCVGGCTFSTSITFSRDEMDMFLEGLKLIQIFVFVLGILKKILGYMRVPTRGITKGAIPSSFLPPLGICKRPMHELKEMTRDKDLFRQTIYDITSTTTLPPGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K510</accession>
    <name>A0ABM5K510_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505278.1">
        <property type="nucleotide sequence ID" value="XM_050649321.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649321.1">
        <property type="protein sequence ID" value="XP_050505278.1"/>
        <property type="gene ID" value="LOC126883664"/>
    </dbReference>
    <dbReference type="GeneID" id="126883664"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="255" mass="30158" checksum="3354DD0169B66227" modified="2025-10-08" version="1">MYMSTNKQNPEQTGVREDDHRRDTDNETDMENENRKKQSPDDLKWEEGMNSFERELINTFKKKQKMNRSTAPKQSTLVGDEMLENSEDDDDEIGEERSQEEVEKIGDIQNIQQNVFASFLLDDETMNKKKRKGDSLERINDLKRKRLEESIKFPNETKQQKINRKLEELNIKLIEIFTNLSEEKGEKVEMNTELKKLLGVIKSTKNKKEDDSIAENTQQEVKYDHCKLKLEQERQREEQEKIKRALNMGEAKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5K9</accession>
    <name>A0ABM5K5K9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505473.1">
        <property type="nucleotide sequence ID" value="XM_050649516.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649516.1">
        <property type="protein sequence ID" value="XP_050505473.1"/>
        <property type="gene ID" value="LOC126883840"/>
    </dbReference>
    <dbReference type="GeneID" id="126883840"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="264"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="447" mass="51023" checksum="2389C3386A5DAC33" modified="2025-10-08" version="1">MEDVMQMFQCHSTTIGCLGHEIFKTQPIRVTPIWVEQHESVATYLHLQPAVIRALDVISTTWKDPTTSSGAFQLLSAIKTANFQISMHILSSVHSLTLSLSRVLQSENQDLGEAIELADAAKQVLLERRENAEKDFRGIFKTVSEISAKYDIELRKPRLASKQTQRSNVQTDSVQDYFRITIYIPYIDLFLTHIQDRFLNHRKILSNFACLFPNKMKNFNEESCAQLFEPYSSIFRDDSRDIWVDEVKLWRQRIAGKNVKNSLEALDVCNGDAFPNVHQMLRILAVLPVTTATNERSFSTLRRLKTYLRSTMSEDRLNGLASLNIHRDVEVDPQRVLEKFEDIQIEIDDNLEPSNANDLSTTNEVTEEEQTSQNDVTTELIGTNSKIPASNGEHIPILPQCSWMPDPVQIPSNLTSFPTASPQHVLPIPKVEQNKKELLGKKEKQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6H1</accession>
    <name>A0ABM5K6H1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptogyrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505779.1">
        <property type="nucleotide sequence ID" value="XM_050649822.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649822.1">
        <property type="protein sequence ID" value="XP_050505779.1"/>
        <property type="gene ID" value="LOC114344856"/>
    </dbReference>
    <dbReference type="GeneID" id="114344856"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF20">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011282">
        <property type="entry name" value="Synaptogyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="228" mass="24883" checksum="6F987C1C3DFBE84C" modified="2025-10-08" version="1">MEAAGAYGGGKAGGTFDPISFVQRPQVILRAVCWLFSVIIFGCISSQGWKFDLAKKRHLCLYNDDANACNYGVGISVIAFLASMGLLVGEYLFEQMSSVKTRKHFVLGDLGFSAFWAFLYFVGFWYLASQWGKSEPPPNGVGVNNVQAAIAFSFFSIFAWAGSAFFAYQRFRQGAGAAFATNYENEAGMPASYPSYPGGPETDTPYQEPPFSAGPNQRGQTDFQAPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K6W9</accession>
    <name>A0ABM5K6W9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tripartite motif-containing protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050505932.1">
        <property type="nucleotide sequence ID" value="XM_050649975.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649975.1">
        <property type="protein sequence ID" value="XP_050505932.1"/>
        <property type="gene ID" value="LOC126884130"/>
    </dbReference>
    <dbReference type="GeneID" id="126884130"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25464:SF2">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25464">
        <property type="entry name" value="TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="7">
        <location>
            <begin position="340"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="578"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="79110" checksum="FC27CA43367A3375" modified="2025-10-08" version="1">MDGLRLAIQTRLGERMVSMNSTLVETVSINYEDFNESFLTCGTCLCMYDGQEHTPKLLQCSHTVCLHCLTRIAASQTRDTGTFRCPICRELIHIPRGGVSALPPSFLVNQLLDLMSRQRREVIPKCSVHINQELLFCETCDTVFCTLCTGGSHNDTTTSCEHTIIPFSIAIKRMSEILLYKANECISKLSQAQEGVSAELGRLDTAKETCLDKINETFQQIQTLMDQRKQEIIDSVNTICTEKRRVLEEQHTLIENEKNKVEQECQGLQYQVEVRNITQRIEILSEKLDSTVALSEPRENAFLTCDFDLNDSFEQIQQHLSVLGKVRTSTTFPRLCTAKLEGSTIAGIENYVTLTTVDYHGNERKNGGDPVEAELLSAAAEESINPSHSEETYPVRIEDCDDGTYKLYFRVPKSGRYGIKISVINRPIKDNPLYFDVSDHNNPICVYGTKGSGKDEFMQPVAVAVDEKDQSVYVLDTGNSRIKVLTDQLEFMKHVTNEGLLGRSCTGIDITNNGLIVVNWRTKYLTEMTTDGETIKSFTYNAFQEPIDVAVDKNYGHILIADNGMNCVFVFDSEGKILFQVGKKGTFNLISSVAVGPLGEIVVADSRVQMFSAKGDFMEVIYDEGKGKGRYGGIAIDPENKVLLTRTEQKGRTYVQLLSLTENNVNQCIDSHDAKLKRPSGVAVTNNHHVVVVDLGNNCVKKYRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K7I0</accession>
    <name>A0ABM5K7I0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506140.1">
        <property type="nucleotide sequence ID" value="XM_050650183.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650183.1">
        <property type="protein sequence ID" value="XP_050506140.1"/>
        <property type="gene ID" value="LOC126884251"/>
    </dbReference>
    <dbReference type="GeneID" id="126884251"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="524" mass="61296" checksum="B01D240E74F705F1" modified="2025-10-08" version="1">MEIKQEYSETCKVEREYDDLDDPLLDGFKCKIKEESNPESTNHTFDCSTLKEFPIETVLCKVERECKDLDVHILDGFQCKIKKESNPESANYTFDCSVLKEFPIKTETCKVERKYNDFDNPVLDGFSCKINEESNAESTNYTFDCSALKEFPIETEIEQDGNKPTCSKAKPKTKQGITRGEVQTRQGPYNCENCFKTFSHPSTLKRHLMVHTGEKPYKCEICFKQFSEAGTLKAHFRVHTGEKPYKCKICFKQFSESSTLRTHLRVHTGEKPYKCEICFKQFSQTSILKKHLTLHTGEKAHKCEICVKQFRDASALKSHLKMHTGEKPHKCEICFKQFTEVFYLKRHLKMHIGEKSYKCEICLKSFIESGNLKKHLRTHTGGKAYNCEVCFKQFTTASNLKRHLRFHTEEKHYKCEICFKQFSQAVHLKTHLKVHSGEKPYKCEICFKQFNQAVNLRRHFNVHTGEKPYKCEVCFKQFTTASNWKTHLIVHTEEKPYKCEICFKQFSQAINLKRHLKVHLGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K9S6</accession>
    <name>A0ABM5K9S6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050506941.1">
        <property type="nucleotide sequence ID" value="XM_050650984.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650984.1">
        <property type="protein sequence ID" value="XP_050506941.1"/>
        <property type="gene ID" value="LOC126884766"/>
    </dbReference>
    <dbReference type="GeneID" id="126884766"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="626"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="738" mass="84076" checksum="B44E411C7D3B7488" modified="2025-10-08" version="1">MAALCPGVQYGLSSQQNYGENRDLIFVKLTDSALRAIEDYLKNQNKFYHHKPTIKFLGNENGELSFPSLHHNMGSTSFSFSMSSTADMEGPGGSFECIKQVGTPRGPLEGLGSIPHKIRIHANDDVYEVTRNRMTEAEDKYKNKCTREIKPNQTDIGRKVKVKQSRMSIHPVRREMPSMRDSLLKQPSSQPYQPKPSIAPPPPASAVVHSSTNGHLSNGLGSNHVSSSRPQMNVAKKLSVPEIPRRPPNSPISNRKPQTLTPPGGGSDGGSSGSGQSPTSTLPGSPPLISTTSAANKRPGYHEGSDGFSYKRQRIAHNAPKHHPDPLYHQPVENNSQRRPVTDSRDASNMNPRSRESPSNGNGIGGGGSYGLNGHNVNSLMDVKAKRECSDEEDDVGKRTCDSHFDVIQEKTFVDSRSISPAVKMLQADKWDRDKPPSDRPNGIVNRIPNGVNRSQHQNRPQDVANDRIIDRVSDRVNDRINDRANDRVIDRINDRVNDRVNDRLNDRINDRANDRVNDRVNDRINDRVDRVNDRVERVNDRINDRVNDRVNERVNDRINDRVHDRINDRVNDRISDRVVNNKYTNVTSSTENRIARVSPDSQTEGLPNSDVDGNFNNESENEEFPDYKKQYVTIQDADQRRRYKADFNADYTEYRDLHSIVEKVSRRFALLEERLKKENENSPKYKDIKKQIVREYQENKNLDHQRTMRRFQYLHDKLSHIKRLVMEYDQEMTDSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KBI6</accession>
    <name>A0ABM5KBI6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507556.1">
        <property type="nucleotide sequence ID" value="XM_050651599.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651599.1">
        <property type="protein sequence ID" value="XP_050507556.1"/>
        <property type="gene ID" value="LOC126885173"/>
    </dbReference>
    <dbReference type="GeneID" id="126885173"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="144" mass="16423" checksum="3C76C75622E904F2" modified="2025-10-08" version="1">MNSRPICPLSSDPNDLSALTPGHFLTMEPLSASPEETLLDVPHNRLNRWQLLNKLHQQIWERWSKEYLQTLHQRAKWNSPSPNVQLGTLVVIRQNNIPPLQWPLGRIIEVHPGSDGIVRVATVKTNSGIYKRSIVKLCPLPFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KC12</accession>
    <name>A0ABM5KC12_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507726.1">
        <property type="nucleotide sequence ID" value="XM_050651769.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651769.1">
        <property type="protein sequence ID" value="XP_050507726.1"/>
        <property type="gene ID" value="LOC126885277"/>
    </dbReference>
    <dbReference type="GeneID" id="126885277"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="337"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="581" mass="68630" checksum="E5646D076A24C061" modified="2025-10-08" version="1">MMGEEYVGYTRSKDGTVKHDTKRNKRMLGPKCDSVFCKKAANRFCLRLSEEIRQTIFEKFWSMSWEQKRLYVLHMTTYTEKKRTYTKNPSRRKGTFQYYLQIEDGKHQVCKQTFLGTLGIKERMVRHWVNEGSMFGTQSSQDDKNKNKTKKKDTSVHSVEQNRKLEQLRLFLDSLPKIESHYCRKKSNKLYLEEDFKSKTDIFQLYKNKCLDEDVLPLSISTFLKEFDEGNLALFKPRKDQCDLCCGYKMQQIEEIIYRNHILAKDLARKEKDLDKKKAQDQAIFTMDVQAVKLCPQLQSSSLYYKTKLQVHNFTIYNLSTHACKNFVWNETEGELCCSVFVTCIIKHLVSALEMDKKPIVLYSDSCGYQNKNVILSNALSILATQFDIEIEQKFLEKGHTQMECDSSHSLIERRLKGKDIFLPTDYINIIKDARKKPMPLEVEYLDHSYFLNFDNPNLMRYNSIRPGKLNSPLKVADLKCLKYLPSGDILYKTKYDSPYEILPQRQKTIILDEYLPKPLYSKRLEISKKKWLDLQQLKKVIPKDTHYFYDLIKNYEKTEESNKKAKKPIYSYRLIIKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCL4</accession>
    <name>A0ABM5KCL4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507932.1">
        <property type="nucleotide sequence ID" value="XM_050651975.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651975.1">
        <property type="protein sequence ID" value="XP_050507932.1"/>
        <property type="gene ID" value="LOC126885408"/>
    </dbReference>
    <dbReference type="GeneID" id="126885408"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="186" mass="21220" checksum="2F35B63A61A2DE3D" modified="2025-10-08" version="1">MEIVRYPGVVSTIRSLLCYTPEDSNFLSTAGWNYPNSLHLSEDTFSLLIPIKHIFNIFNDYNKLTYGRQMFRFVRARNDRNCIVVQEPSGSTTVTTVSLTIASMELKVKHAVPNDDVKIDLMTPIKNNTPITIPFRKWELNELPSVTAGSRREIWSVKTTSAVERPRYIIVAFQTSKRDDIHAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF11</accession>
    <name>A0ABM5KF11_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508792.1">
        <property type="nucleotide sequence ID" value="XM_050652835.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652835.1">
        <property type="protein sequence ID" value="XP_050508792.1"/>
        <property type="gene ID" value="LOC126885997"/>
    </dbReference>
    <dbReference type="GeneID" id="126885997"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="537" mass="63225" checksum="5A1CAD37C4ACDF73" modified="2025-10-08" version="1">MTVKAEIKEELVEDDPRYIIENQLSTSLNLGDFKNEDTSGFTQDENKTKIMETFFEHSSNKGHYMSRHAEEKPANKNRKVQTRQGPYNCEICFKKFSYTSWLTRHLMAHTGEKSYACEICFKKFIHASNLKTHLRVHTGENPFKCEICLKQFTEKGSLKIHLRVHTGEKPYKCEICFKQFTTASHLKRHLRVHTGEKPFKCEICLKQLTRASHLKSHWRVHTGEKPHTCEICLKQFTGKGNLKTHLRVHTGEKPYKCEICFEQFTEKKSLITHLRVHTGDKQSFTYKCEICFKQFTEKSSLKTHLRVHTGEKPYKCEICFKQFSEKSTLKKHSKVHTGEKPYQCEICLKQFTEKSSLKTHLRVHTGEKPYKCEICFKQFSYDGDLKRHLRIHTGEKPHKCEICFKQFIQASNLKTHYLRKHTGEKQSFTYKCEICLKQFTDKTSLKTHLRVHTGEKPYKCEICLMQFSEKSSLNTHLRVHSGEKPYKCEICFKQFTTVGQLKTHLRVRTGEKPYDCKICFKQFSQKGNLKKHLRSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFK5</accession>
    <name>A0ABM5KFK5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508970.1">
        <property type="nucleotide sequence ID" value="XM_050653013.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653013.1">
        <property type="protein sequence ID" value="XP_050508970.1"/>
        <property type="gene ID" value="LOC126886162"/>
    </dbReference>
    <dbReference type="GeneID" id="126886162"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1290" mass="149927" checksum="D28A2852F23477DF" modified="2025-10-08" version="1">MLAKLIQLIASILGLIRNDYNDENLRKGLIECNKTSKKLRDSMRYAKTIGEKQHLEAQMRQVKTLRNQLKAEQKKGAGLNTRPETAYKRVQWDDSISAFNSRIRTGVISNLKHKDPGSFLVDCKALFKRRIHNALKQNEAVKVNMVFGGEFQVASGDKVLNDTKYFTTSNSPIYRDTNIDEWFEKKVVEPISRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIELPPQIKTKQACINVKNDDEACFAWAIISALYPTTKNVDLMTSYPHYSSILKLKGIQWPMTIKQIPNFEKQNNMSINVYILKKEKKNYTTLPTFLTKNKKDKHVNLLLVQDTYDEQGPIRYHYVWIKNLSRLLSNQLSKDKGTKYFCDSCLHYFITKEKLNVHKACCKGRSDVNCDRCLQTFSSSTQLEAHTNDCVRINETAIKMPEQSRKMLRFKNFWNKIKAPFTVYADLESALKRTGDPKKHQEHIPVAVGYFFKCSYDDTLSFYSSYRGKDCMKWFADELNQLAVNVSTVFMCPYDIDMTSQQESDFHAATHCHICEQRFSLDDKKVRDHNHLTPEHNYRGAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIVNDIATQIKGPVDLLPITKEKYISFTKHLNDARIKFRFIDSFRFLASSLDKLSSYLTEYPNLRSQYTSLPEENFHLLTKKGIMPYDYIDSFIKFTETSLPPIESFYNKLDDKPCPRRHYHRAQDVWSSFSCSTLGDYVDLYMKTDILLLADVFEQFRTSCLKTYNLDPAHYFTLPGFTWDAMLKHTKQELELLTDPDMFLFVERGIRGGLSQVCSKRRVHANNKYMTSYDPSKPDSYLMYFDVNNQYGWAMSQFLPYGGFEWVDANIDVLSIADDASEGYFLEVDLAYPQHIHDRHKDLPFCPQSLNPKTMLPPKRPREQTKLMATLHDKERYVIHYRALKQALAHGLVLKKIQRVLKFKQSPWLKSYIDLNTNLRKAAKNEFEKNLFKLMNNAVFGKTMENVRKRVDIKLLTEWEGRYGAEARISSPLFKNVTIFNENLVAVEMRRAEIWLDKPIYVGMSILDLAKTTIYDFHYGYLNRRFGENFTTCYTDTDSVIVEIREKDPYEAMKTDCHRHFDTSDYPKDNIYGIPQVNKKVLGMMKDENNGCIMTDYIGLRSKLYTIKVAITDNDIKKLKGKLIDQEYEDDEIEILIKNYGVTKKAKGVKKSVVNTKITFEDYVECLDNFTTKTASQNLIRSDKHHVYTITQSKIALSPNDDKRNHLPESYDTLPWGHYLVDNLELDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGF0</accession>
    <name>A0ABM5KGF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.10.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050509274.1">
        <property type="nucleotide sequence ID" value="XM_050653317.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653317.1">
        <property type="protein sequence ID" value="XP_050509274.1"/>
        <property type="gene ID" value="LOC126886395"/>
    </dbReference>
    <dbReference type="GeneID" id="126886395"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001824">
        <property type="entry name" value="Tyr_kinase_rcpt_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00240">
        <property type="entry name" value="RECEPTOR_TYR_KIN_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="543" mass="61164" checksum="54A2BA11175692EA" modified="2025-10-08" version="1">MVKKNADNTYIKALASELKIMAHLGKHLNVVNLLGACTKNVAKKELLVIVEYCRFGNLQNYLLRHREHFINQIDPHTGEVDYKIGLEHLDRTYSVSSNRSQVQSPLMKYAAVAFSDSAYGARLVPPSPMGDYRAHAASEATDMTTVTQGDDGAVLSNNSVQPEWRSNYKGDYKGNIYPISTNDLIAYAFQVARGMEYLASRKVLHGDLAARNILLSDENIVKICDFGLAKSMYKSDNYKKRGNTPLPVKWMAIESIRDRVFSTQSDVWSYGIVLWELFSLGKTPYPGMEADERLYYKLLDGYRLESPEYSPKEVYQIMTKCWLAKPVGRPSFGTITERIGALLEESLRKHYIDLNDPYLAINAKMLEGQNDYLSMVSSPSFDVIASPHYVNDITTQQSSDEGYMSMKPSTIFSPRKIEEEVFKFTVSNRKDLTSEEVKGQEALPMLCVISETDTETPLNNPSTSSDPNSISNPMYHLPPTIPNNGTYGQTEIVKSADNYVSMQGSKNLIKDRSAQEIKTVMDEKKESHPYVNDELQGLTCIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGJ5</accession>
    <name>A0ABM5KGJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050509326.1">
        <property type="nucleotide sequence ID" value="XM_050653369.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653369.1">
        <property type="protein sequence ID" value="XP_050509326.1"/>
        <property type="gene ID" value="LOC114329917"/>
    </dbReference>
    <dbReference type="GeneID" id="114329917"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="240"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="378" mass="41442" checksum="2F1546C401F3FDA7" modified="2025-10-08" version="1">MANLNFTRNIGGNNLGRTSVSFGSNSMSGHVTPVLGQRIPSERRALPTMGNANQMGHMSTLGGYSSFNSVFGSGDTNTPSLLDFNEFPSLTNRNSGDNVPQPSPMPGGKPYVGMVKQPTSESSEFTMSSEDFPALPGTQNREGASPGSNASGDKGVSGGAGDGVNSREGDKSGSKSGIQTSPDGRITNIPASMVNDQFGIVGLLTFIRAAETDPNLVSLALGQDLTALGLNLNSPDNLYPTFAGPWAEHPCRPQDIDFHVPPEYIINHAIREKLASMKLSRYKDDLLFFMFYNNVGDVLQIAAASELYSREWRYHIEEKLWMTQVPGMVLMEKTSTYERGTYYFFDPQNWRKIPKEFYLEYSKLEGRPVMNQNLHHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL54</accession>
    <name>A0ABM5KL54_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar fusion protein MON1 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in membrane trafficking through the secretory apparatus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510931.1">
        <property type="nucleotide sequence ID" value="XM_050654974.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654974.1">
        <property type="protein sequence ID" value="XP_050510931.1"/>
        <property type="gene ID" value="LOC126887440"/>
    </dbReference>
    <dbReference type="GeneID" id="126887440"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="4">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="5">
        <location>
            <begin position="246"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="6">
        <location>
            <begin position="374"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="483" mass="55090" checksum="C2A91C1619757A88" modified="2025-10-08" version="1">MSTVEIEPGAAPESVLVTTDTTLDHFEQMSSSLEEIKCTNQSNHEEEHNENTNNENLDESSNDNETLTSEEDFELNKDWINKDKHVFVLSMAGKPIYSRYGNEDKLAWLFGVMQTLVSFIQSSDDSIQSIHTGDTRFVFLIKKPLILVAVSKTHENDSQLRLQLNYVFNQITSILTLTRLNKIYEQRQNYDLRRLLSGVERLIDHLLTFSENELSVMLGAVQCLSLPASVRDSISSAIVGACSKIKNLVFAILLANNKLITLVRMKKYCLHPADLHLIFNLVQASESFKNSESWTPLCLPRFDASGFLYGHVSYLSEDCQACLLLLTVERDVFFTLSEAKQKIVEKLRRNNCLESINESLAAPGYSCASAGFVEIRHYLYKCKSTAQFYQPVLSPPYTQAKSYLTELYKRAHQRLHNSTKPLKLMFERSSREAILAWDTKGFELFVVFEPLIDTSLAILLVGRLLNWIKKQEDKLFHLNAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMI6</accession>
    <name>A0ABM5KMI6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Craniofacial development protein 2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511410.1">
        <property type="nucleotide sequence ID" value="XM_050655453.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655453.1">
        <property type="protein sequence ID" value="XP_050511410.1"/>
        <property type="gene ID" value="LOC126887736"/>
    </dbReference>
    <dbReference type="GeneID" id="126887736"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="25409" checksum="246501F1E79BD85F" modified="2025-10-08" version="1">MGDMNGRVEKQNYGIEKWLGKEGEETRNDNGTRNINLCIENDLIIGNSKFTHKDVHKYTREERSRGERSIIDYFLINFEIWKAVKNIKVKRSAEIGSNHYLVKMSFRIIKYIQNDKKRKIIKEKIRSYKLKEIEVEKRYHKCLEELRKRANKYQNIEERWKDYKHSLLVAAKESCGVTRISNNSKKTHSMVDKRLRKNSTRKETTVEKILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRT2</accession>
    <name>A0ABM5KRT2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512893.1">
        <property type="nucleotide sequence ID" value="XM_050656936.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656936.1">
        <property type="protein sequence ID" value="XP_050512893.1"/>
        <property type="gene ID" value="LOC126888586"/>
    </dbReference>
    <dbReference type="GeneID" id="126888586"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF8">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE KIAA1586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="495" mass="56101" checksum="C88DFEF130A1800E" modified="2025-10-08" version="1">MTDGTSDNNIKIPPFWPNDPEIWFLQVENQFTLANIKSDATKFNYIVANLETAYISEVKYIIVLPSATESASVKRELNTLGLPKGTKQDKSNVVSVDELAIGNSLNKNEQISEPSTSTNKEKETKWPDVWTEEMWTRKKETYPWIDCKEGKLGCKVCFEVTTMGAFKKEHVSLSHEWRTFQVSCYGSNRTNQLKSLRKKIIEHKQSKAHSTAQAIVESSHKNPITQLVDSANTAHMESTKAIFRSAYYIAKNDRPYNDHFGLLELQKLNGVDIGVGLHSRYSAVEIIDHISKEMKLRILNKVKEVSGKISIIIDESTSISSKSVLIIYLKCEISKEKSPNILFLDLVELPDQRAESVFNSTLKCLEQYGFDNGYLKQNLVSFTSDGASVMLGKHSGVAKRFSTLYPDIIVWHCLNHRLELAIGDAVSEVAGVNHFQIFMDKLYSLYSASPKNKRELKDCAQELDIQMNKIGRVLSTRWVASSFQHRLKKANIVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KUP0</accession>
    <name>A0ABM5KUP0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050513904.1">
        <property type="nucleotide sequence ID" value="XM_050657947.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657947.1">
        <property type="protein sequence ID" value="XP_050513904.1"/>
        <property type="gene ID" value="LOC126889565"/>
    </dbReference>
    <dbReference type="GeneID" id="126889565"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22162" checksum="00C0E8219BA76E65" modified="2025-10-08" version="1">MDKWLSSVKRPCAQSNVPPSSSQELNCAVIQDDVKNSLPSSSTSEPDCADKDRSNPQHVALIDFQVTCLHSPILDISAFLYLNLSSEDFPNFKEFLEFYHSELSSVLTDLGSDVNKLFPKHVMQEHLKKFLHYGFCLTVAFLEIFYVDNEDVPPLIDEETNEIMGGLKDLKLKSRDEYVRRLVSIVDSFFNSGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWB2</accession>
    <name>A0ABM5KWB2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 4d2-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050514474.1">
        <property type="nucleotide sequence ID" value="XM_050658517.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658517.1">
        <property type="protein sequence ID" value="XP_050514474.1"/>
        <property type="gene ID" value="LOC126889830"/>
    </dbReference>
    <dbReference type="GeneID" id="126889830"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57987" checksum="26C5B191D7F96F68" modified="2025-10-08" version="1">MLILSVIVAVFVVIVVTLVVTWLRALRKYDSLKNVPGPTPIPIIGNALLMGTTTVALLQTFLDLQKKYGNFYKLWMGPRLHLVIYKPEYLEKIMTSHVHLDKTSGYDLFEPWLGDGLLISTGKKWKLRRKMITPTFHFKILEEFVKVFNKSFTVMTEIMEKKVKQNSNESIELSEHINLASLDAICETAFGTCLNVQRNGNREYVQALGRFLEIFVVRFFSAWLRNPVLFRLSKYYKEYSETLKILHTFTDNIIKARKEEYKTHKLDQEQNSDDSGIKNRVGLLDMLLQAKENGEDIPDEDIRAEVDTFMFEGHDTTSSGIAYTLYALAENPDVQKKLYNEIVDTLGSDKNMDLTISNLNDLKYLDIVVKEAFRKYPPVPMIERKIVEDMDLDATTVPKGTDVSIFLYGMNHDPKVFPNPDKFEPERFLPESISSRHTFAYLPFSAGPRNCIGQKFAVYEVKLSVIKFLLKFELIQDPNFIPQHGLTSVLKSKNGLKVKPRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KWI3</accession>
    <name>A0ABM5KWI3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_050514549.1">
        <property type="nucleotide sequence ID" value="XM_050658592.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658592.1">
        <property type="protein sequence ID" value="XP_050514549.1"/>
        <property type="gene ID" value="LOC126889884"/>
    </dbReference>
    <dbReference type="GeneID" id="126889884"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="278"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="424" mass="46933" checksum="1BFE7FC795F609F9" modified="2025-10-08" version="1">MSLNTLAKLSKVGAEIAVKNANKNIPIRCSSKFAPFNWQDPLNLESQLTDEEKLVRDQFRSYCQEKLMPRVIEANRKEVFHREIMNEIGELGVLGCTIKEYGCAGVSNVAYGLLTREVERVDSSYRSAVSVQSSLAMGAIYYYGSTEQKQQYLPKLAKGEYIGCFGLTEPNHGSDIGQMETRAKYDSSSKTYILNGSKTWITNSPISDIFIIWARCDDSKIRGFIINKKEHGKGLEAPKIEGKFSLRASTTGMILLDNVKVPEDHLLPNAVGMSGPFGCLNNARYGIAWGALGAAEACLEIARNYTLERHQFDKPLAANQLIQKKMADMVTEISLGLMGCYQAGRLKDQNLHTPQMISLLKRNNAGKALEIARNARDMLGGNGISDEYHVIRHVMNLEAVNTYEGTHDVHALILGRGITGIAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXH1</accession>
    <name>A0ABM5KXH1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514891.1">
        <property type="nucleotide sequence ID" value="XM_050658934.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658934.1">
        <property type="protein sequence ID" value="XP_050514891.1"/>
        <property type="gene ID" value="LOC126890087"/>
    </dbReference>
    <dbReference type="GeneID" id="126890087"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="161" mass="18520" checksum="D49C7E3464054F6E" modified="2025-10-08" version="1">MSSQCKPKLSDLRLTELRTELENRELDAAGKKADLVVRLKIALQEEGHDPETSVFEDRQTALISSISKEISQVSTDITSANGWSEKDKAVNLVIALRGEALDVLQTIAVEETNYFEQLMKRLNMRYGHEHLEYVYQARLKNRRQKKDEALQEYELDIARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KY07</accession>
    <name>A0ABM5KY07_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pao retrotransposon peptidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515081.1">
        <property type="nucleotide sequence ID" value="XM_050659124.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659124.1">
        <property type="protein sequence ID" value="XP_050515081.1"/>
        <property type="gene ID" value="LOC126890266"/>
    </dbReference>
    <dbReference type="GeneID" id="126890266"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40867" checksum="F8BB5AF5294B5653" modified="2025-10-08" version="1">MYVDDFISSFPNVSEAIVTHTQLVNLFQKGGFKLTKWMSNSNDLLSTIPEPLQLVKTKQFVKSVSKVLGLQWEEKCDNFSFGLEIPSSTRCTKRNMLSLVARMFDPLGFLSPITLLLKIWIKKLWTLKVDWDSTVPKEIEIAWEKFQNEFHVLYKIQIPRHIAVTPNSSLSFVGFSDASAAGYAAIVYSRVVNCTGQVKVTLLYSQSKVSPMSKITLPRLELCGALLLSKLLSHAIETYSPRHNIDKIFALSDSMIVLNWIKSSEKNLKIFVQNRVVTIHKMVPSEYWFFVPGKENVVDCASRGLFPSSLVNHSTWFTGPNWLLLEPEYWPIQSVNGQEIMICDSEYRSQTFFVGRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0F4</accession>
    <name>A0ABM5L0F4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050515920.1">
        <property type="nucleotide sequence ID" value="XM_050659963.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659963.1">
        <property type="protein sequence ID" value="XP_050515920.1"/>
        <property type="gene ID" value="LOC126890776"/>
    </dbReference>
    <dbReference type="GeneID" id="126890776"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF98">
        <property type="entry name" value="RE43130P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="72"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="370" mass="42682" checksum="F73926822D973C38" modified="2025-10-08" version="1">MPPLRNNPVHHQLESPTSNVSAQYSETQIKGIRYFEQDLAIPNVIVYFMTHLITLIGCWKMVTGDIKFSSFAFSYVLAALALLGVTAGAHRLWAHRAYKAKLPLRIFLMLLQTSALQNDIYIWVRDHRIHHKYTDTTADPHNSNRGFFFCHVGWLLMKKHPDVKTKGKNIDLSDVAADPVVRFQRKYYLLLGLSLTFIIPSMVMVYFIHETVLNVIVICIAKYMLTLHGTWCINSFAHMYGWKPYDCSINPVENATLSFLGLGEGWHNYHHTFPWDYKAAELGNYRANLTTGFLDLMAYLGQAYDLKTVSQDMIKKRAARTGDGSYNFDKVPLDNGNTKEHHNFHEDYVWGWGDKDMKEEFRNATIKFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L169</accession>
    <name>A0ABM5L169_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516187.1">
        <property type="nucleotide sequence ID" value="XM_050660230.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660230.1">
        <property type="protein sequence ID" value="XP_050516187.1"/>
        <property type="gene ID" value="LOC126891051"/>
    </dbReference>
    <dbReference type="GeneID" id="126891051"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="370" mass="42307" checksum="24134FBC1D41FF0F" modified="2025-10-08" version="1">MSAKDIQNSQREGEEDESYCTHLNLRLSSNSAEEPTFEDNINELVEYINNDMDPTNRLNRTGKDGLKARVTAIAMNMANLEGQNKILREVERLRNESQTKERMSYARVTAQPAMATKSEQERKIEMRKEENTLFITSDKATTGRKVQEELTEVLNPRTEKIRINRMKTVGKALIIDAATKEDLDKIKNHTIVKRNFKCELPKKRKPLVILYDVSSSAKEEDIMEDIRAQNFENMSKEEFEDSFKVRFKTGPRGKSTVHYVAEVSPGLRKAIIKDKIYIGFNAINVRDYIVVPKCLKCQDLGHVAKHFTKETACSHCGGAHEKKECDKAGQPKTCIPCKARGKADCKKEHKDCPTHKMLVDRLILKTDWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1J6</accession>
    <name>A0ABM5L1J6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050516308.1">
        <property type="nucleotide sequence ID" value="XM_050660351.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660351.1">
        <property type="protein sequence ID" value="XP_050516308.1"/>
        <property type="gene ID" value="LOC126891169"/>
    </dbReference>
    <dbReference type="GeneID" id="126891169"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="140" mass="15695" checksum="89C97F1530F2DC9C" modified="2025-10-08" version="1">NRSTNFSKGEELLLLQEIEKYKSIVECQATNKVNSKEKEEAWQKILSNFNSKNLEFRTVGQIKNKYDNFKTRSRKIVASEKTYLRGTGGGPPIKTVADPVVEATLNIINGKTVVGHITMIDSDETIPWENIPSTSIAHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L412</accession>
    <name>A0ABM5L412_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517182.1">
        <property type="nucleotide sequence ID" value="XM_050661225.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661225.1">
        <property type="protein sequence ID" value="XP_050517182.1"/>
        <property type="gene ID" value="LOC126891884"/>
    </dbReference>
    <dbReference type="GeneID" id="126891884"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="165" mass="18509" checksum="143F821B2AA38620" modified="2025-10-08" version="1">MELSKERQNRMSTGGGGGIPDINILPDVEVIATHLSEEVTNLVDSDAQYMGNKLRSRSRSPVFRNNPVASCDMVTVKETPSTSILNEEILSPRSLIMDTEKTNTSVTSQSKKKSTVDRLMEIRINNALLEREQMTELHEARMLVEKAILEKVELEKQLLSSKTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L542</accession>
    <name>A0ABM5L542_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517557.1">
        <property type="nucleotide sequence ID" value="XM_050661600.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661600.1">
        <property type="protein sequence ID" value="XP_050517557.1"/>
        <property type="gene ID" value="LOC126892135"/>
    </dbReference>
    <dbReference type="GeneID" id="126892135"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="281" mass="32758" checksum="0061023549D18A7E" modified="2025-10-08" version="1">MHCVDEAMVPYYGRHGCKQFIHNKPIRYGYKLWVGASRLGYVNWMEPYQGATTNISEKYIDYGVGPSVVLEYADVLRTRWPNKRMHLFFDNFFSTLSLLELLSEKNFNATGTIRENRISNGPLTNSKEIKKEARGVFDFKKTENQNIIVVKWHDNSIVTLCSNAVGVNPLHRVKRFSRKERTNIQVSQPHLINLYNANMGGVDRCDQNLSLYRISLRSKKWYFPLVAHCIDVALQNAWQLHRQRGGDLDQLRFRRRVATTLLLQNKKKKHIIKVISHLPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L576</accession>
    <name>A0ABM5L576_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-coumarate--CoA ligase 1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517589.1">
        <property type="nucleotide sequence ID" value="XM_050661632.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661632.1">
        <property type="protein sequence ID" value="XP_050517589.1"/>
        <property type="gene ID" value="LOC126892160"/>
    </dbReference>
    <dbReference type="GeneID" id="126892160"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="487"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64069" checksum="C7BB08E96659F5A8" modified="2025-10-08" version="1">MSVSLCISNSRGNEAFWLAIFSSSMDLLEIFTKDPLAEPDNNEESEEEYTFYTPFKFEPDPRGLGNYLFNRMKKHRHHIAQYIADTDEEQTYAELLQRCVRTACHLSTRNLTKDDVVVLCSYNHKESAVPFIASLFLNVPVASMDPSSSLMESAYLLKDIKPKIIFVVPEGLELMETSVKQAGLDTEIVVYGSSDTHTEFSSFLEPHENEEKFAPTEADSLKDTAVIMFSSGTTGLPKGIILNHLGLLGQALILPVCGNIGNIYLTYSTLYWISAVIYQLAAIIMGGAKVTVQKMDPHETWKLIDKYKVTTVFGAPSLAAALLKVGRPDGLDTSSLWSFIVGGGYIPKPLLLELRDLLPGTFVCNAYGQTEVSGVLTSFNTTNVKETLYLHSKPTSVGMVIPGLKAKVVDVYTGAICGPNEEGELRIKSDFLMSGYHNHDTSDSFDSDGWMKTGDIVNYDKDGCFYIKDRIKEMLKYKGFQIAPAMLEQLVMTHSSVAQVVIIGIPHDADGDHPMAVIVPKESSTASLTEEDIIKFVDERVSDTMRLRAGVKFVSSIPLTPSGKIRRRDVKKMVLDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5X0</accession>
    <name>A0ABM5L5X0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Breast cancer type 2 susceptibility protein homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517834.1">
        <property type="nucleotide sequence ID" value="XM_050661877.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661877.1">
        <property type="protein sequence ID" value="XP_050517834.1"/>
        <property type="gene ID" value="LOC126892359"/>
    </dbReference>
    <dbReference type="GeneID" id="126892359"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81878">
        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="9">
        <location>
            <begin position="1199"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="7">
        <location>
            <begin position="1296"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB3" evidence="8">
        <location>
            <begin position="1639"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1814" mass="204048" checksum="786C3D96E78AEFD6" modified="2025-10-08" version="1">MNDIESVSSAEDDLEVKNLFLNNAATSEVETDKPLSPILKSALNRKGFGRKHRNRIQLSKKFEKEKCTETCVDTEIPEINEDSFTLSATENLVECLERLEEIEKNREIAYKHLVNNKKSNLCFKKPTLPAPKTPKRLKIAVSSPVPFQEPVQIEHNEEPFERLILTPHTPIDLPKSSSFQTATGKYIHIDSEEIENNSRIFECDQNKYSFLKKSDYSQNINTTITNSSTVGQCDEITFSQAVSGSGITDTQMLFAIDNALDDHVLKTDEFRGFTAIEKSIAVDLAAKFQIYFNTICRPNHKRQIVDDQGPNKRLKVDTEVISNSYTSDITNFENMLGQNNSCIIDTKFGGFSSAAGKKIVISTNSLSKAKSLFDNIDSDLNTNYSNSKEIRNTTLGDRGLNLQMHCHIGNISSTKNICTSERRVNMNFTSQNKTSVLSKNDQKACSSVKDKLKYFDNLIEADENVSEVHDNNENHFGSVSSATTLGGFSNAAGKQILVSADSLSKVKSLFDNIDSDLNTNYRASKEVRNNTLGDKSLNLQMYCDISSRSSTKNICTSETKVNMNFDSQNKISMLSKNDQKACSSVKDKLKYFDNLIGADENVTEELTDNKNQYGGFSNAAKTFEGFSNAAGKQISVSADSLNKVKSLFDNIDNDFNLNNSDLKETQETKRLGDKRSNSQRFSYIKNVSVPNSHTIEGPKMNSDSSSSTLVTKDYQKASITAKQDVKKFDHLEEELSKPTENALDGTTSENLNLGNYKNSFTSASITNNNAFGGFCKASGKELIVTSNALSKAKALFEDMDIDPNLNLVKTVKPLSEQNTGLLNHETKTIYHNKILKISGAQENNPLQPKHNDQSMSEVQSNKGNASVKDKLKYFDQLIGDDLDFVPKTDSKLPNLVNKHSTTKPPTVVKQKLEFFDNLLGKDDLPLKNNSSSNKNPQNVVSFSSTSGLLQLSNVPLKKTKTSFEDSSETKSNSSFKTPVKGISNSSAKKTKRKLGVSSLRQISIPESKLQKARLIFDEELTGISPIKPLPNQIQTNNSIEPSLQTSYTINNSCSTPIKRNIESHESVMDFQEIVTKEPGITDTEESVIQTEFNLKEDCLVTFTRSENKDLNEVILDFGAEARKLEQKLIVLNKRKEILESFRKDKADFDKRPKIGTLSKSKSQSNRILLSSFVEGFQPGASCDSNFNCITPQNAADIHFKESSAVILTEDGATVVPNINNLIGVSEIENAFNAMPGTDPRLIPKGWIKNHYKWIIWKLSSYERMFPDHFKGSLTVEHVIQQLKYRYDREIDKVERSALRKILERDDVPQKRMVLCVSDVKKVGFNSHELELTDGWYGVRTAIDEHLNYQIFAGKIKIGTKLITCGTELMNCDGCHPLDVTDLTFLKICFNCTRRTKWDVKLGYQRFPGPFSVPIHSVRPGGGPIGRIDVFVVRSYPFRYLDKSEVKCVWRNKKAEERRAQAWENERYKKLELIEENIRNEFRSISNPEKLNNNCDISGITCPRTLLEIIENSNDPEMMEAKLTSSQKSSLLNYKQNLLQQKQQEMAAKLKDSAEKLKMSKRDVVAVMKLLVVDQKGTPSKTYNFYVWNATDNHLQLLKEDSCFAIFNVYPKITGDLNSGVKTTFESKPNIKYESDLFKRKLITIEDLFSWNISSHLDEFDTVGIIVQLFVENATQEIWLCDTSARLLLIKISEGPSTCLLLDGLKRGQLISVCNLTYRGTSNELLVSKASANQLTIFSSYPKYKQLQNGLDDLKNKLPKKIDDLLKDCDNRIDKFKHRKSTSIFDESDEDVTLTSSKITSTDVALSLIDFDKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6A3</accession>
    <name>A0ABM5L6A3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NDUFAF4 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517969.1">
        <property type="nucleotide sequence ID" value="XM_050662012.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662012.1">
        <property type="protein sequence ID" value="XP_050517969.1"/>
        <property type="gene ID" value="LOC126892479"/>
    </dbReference>
    <dbReference type="GeneID" id="126892479"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23849" checksum="50BCD717AE1791F9" modified="2025-10-08" version="1">MGKAYSSLKNPLKNFNVESRAHKVISQPKPIPAPRHKIEQDQYDRMLQEYPKEFEESLKKNEELDKNLKSVFVTSQDQNINIKQEANPNRPLPTDRSQVEPSLYGIKEPEPNKVPIGKVTLGNVLEFISKYQGDPKNYNAKVIADKFTLQEQTVRNILKYFRVFEVYLPQERTKTNAKFVGPSLPRVHIIKEFKKQLPKPDSEGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9L7</accession>
    <name>A0ABM5L9L7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds DNA as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CTF/NF-I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050519136.1">
        <property type="nucleotide sequence ID" value="XM_050663179.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663179.1">
        <property type="protein sequence ID" value="XP_050519136.1"/>
        <property type="gene ID" value="LOC114340735"/>
    </dbReference>
    <dbReference type="GeneID" id="114340735"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00859">
        <property type="entry name" value="CTF_NFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="10">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="617" mass="68779" checksum="1D1220848E1DC3B1" modified="2025-10-08" version="1">MFIPDTLRSCMVEPDVSSYLQTPSTGQDEFHPFIEALLPFVKSFSYTWFNLQAAKRKYYKKHEKRMSLEEERQCKEALQNEKAEVKQKWASRLLGKLRKDITQECREDFVLSITGKRSAVCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKAIPLESTDGERLEKNPDCSQPGLCVNPYHINVSVRELDLYLANFINSHEILSGVCYNNNHHNNNNKKEDDRKSKGYTHNPYNGVVCNDIILATGVFSSKELWKLSKSSILHELSEGHPNMNSVKLEHPTFYCNSYPEPGSVVVDRSSSVDSMVVSATYSMPQNTTLVSSSSQASPSTLFYQHSPESHPHQNQVKYPENGHDTLSDFVTFVCQETDNNQNSQMQSSLSRSPKPQYFPSTMLPPPPLPPMARPVAIIRSTCDVNMSGTNSPPASITPPCSEASPADEVPEINSSPPLSPGSHDMRKSPSQRNSVPTSSPYSPSREYSFNHFHGQPGHLFSYPNITGMSGVISPTNLSMYSPTVSTARGTPRSSNITRWNNPLFTLDQEDFSIISHTSSAEPGAIILMDEASASTAPSATDHTGQCCNSANMICDADRFFQGGDTLETSDSRENDRNLIVPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9M2</accession>
    <name>A0ABM5L9M2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tigger transposable element-derived protein 6-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050519141.1">
        <property type="nucleotide sequence ID" value="XM_050663184.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663184.1">
        <property type="protein sequence ID" value="XP_050519141.1"/>
        <property type="gene ID" value="LOC126893215"/>
    </dbReference>
    <dbReference type="GeneID" id="126893215"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46733" checksum="D7BEB955114D9E54" modified="2025-10-08" version="1">MPRNYKRVTEKASWREEELQGALRAIQNGMPLRKAAIKFSIPKSRLHERLKNGTAPSGPSLGRKPVFSVEAENALAVQIKKLAKVFYGITPQEVRRCAFGFAQSNNIRVPFNQERKMAGKDWERGFISRHNITLRKPEATSINRITAFSRNEVTIFFTNLSRLMEKYAFSPNKIYNCDETGVTTVQRPPKIYAEKGQKRVGFVTSWERGKTTTAMCAVNATGTYIPPMFIFARQRMASHLQRNGPPGALYTCSKNGWITEDIFLTWLQHFQAFVKASKEDPLLLIMDNHSTHCTLQAYNFCRDNGIAVLTIPPHSSHRLQPLDVSFYFPLKTAFNSGCSKYLTSHPGEKITPSEIAELFNLAFSRVATPEKAIKGFKETGIFPYNTDIFTDEDFGPAETLQSTVSDALQEPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9N1</accession>
    <name>A0ABM5L9N1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine O-palmitoleoyltransferase porcupine</fullName>
            <ecNumber evidence="9">2.3.1.250</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA</text>
            <dbReference type="Rhea" id="RHEA:45336"/>
            <dbReference type="Rhea" id="RHEA-COMP:11170"/>
            <dbReference type="Rhea" id="RHEA-COMP:11171"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:85189"/>
            <dbReference type="EC" id="2.3.1.250"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.250" evidence="9"/>
    <dbReference type="RefSeq" id="XP_050519147.1">
        <property type="nucleotide sequence ID" value="XM_050663190.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663190.1">
        <property type="protein sequence ID" value="XP_050519147.1"/>
        <property type="gene ID" value="LOC126893221"/>
    </dbReference>
    <dbReference type="GeneID" id="126893221"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF12">
        <property type="entry name" value="PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="467" mass="54934" checksum="433AD5B18691FFC1" modified="2025-10-08" version="1">MSVSLLEEHENPVDFVYDHTYFEETSQDVWEYCVIPSALSIFHILYKIILTNFVFGIVITIVKLPPSLYHIFAGGIGIYLINNLESLEGKCLILIIFMKSYLLLQASRYIQTHFRSNQYYNKTKVRYLSTSNIMKYTLIIVLIVCEYFLLKTEAWMEARGVIMIFSMKLISLAEDIDKGAVKYPSFLNYFGYMFCGANVMFGPWTSFNEYIALYNQTTTKNIWWILGIIRALTISVFFLMISNCWSTYFIPDESNRWLISYREAMSFRTSHYFISFLSEASMLAAGFKGSKIWHEPKNWRYEVVDPIKTEFPTALAIVVTRWNRPMHEFLKKYVYRSWLPHGKFFAVLATFIVSSLLHGFELKVSVVLISIGIFSYLQFTVRRQFSKAFNSCINVYPCKESCRHRFQRNSIFSWMCRLVFSFTTVVHLIFLGMLMDPNTDEIGIFQKWSNLYFISFWIMLVNILLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5LAX6</accession>
    <name>A0ABM5LAX6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="RefSeq" id="XP_050519590.1">
        <property type="nucleotide sequence ID" value="XM_050663633.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663633.1">
        <property type="protein sequence ID" value="XP_050519590.1"/>
        <property type="gene ID" value="LOC126893435"/>
    </dbReference>
    <dbReference type="GeneID" id="126893435"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="633"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="932" mass="108317" checksum="4AD3E4F5A6AFADFB" modified="2025-10-08" version="1">MSFKLDVDRLVKDELEVELQMRGIILTNCKVEELKSTLRSCLVLEKFGKIPNFDLPPDIPAELTSCENKLKEILNIINAFTGTANQIRRIETKFAHLSGRLNRIHSTDTDEMSKRSALLKKLMDLIGEYTTKSNVLKTSNVVSVEMPTDPNFYHHIDLSGLNLNDPNGNSTPTRNISAPNVSNQTNQTSNSTVNPIVFLPSNSDFPSEPVYKWGIKYSGKPQNFSVFLEEVEEYCRSRNVNKIQLFSCARDLFTGNALGFYKLYRNYASNWDSLVSLMKEEFTLSADEIWQDILHTTQESNESIGMFVAKMTSKFEQMPTPVPDSLKMQVLLKNILPFYQERLTLVEVKTPFDLIDLCRKIEKTRINIESFKPSSSSRANSSRHHVVQEVEAFVPKCWRCNEYSHVVKDCKRPKRVFRCFGCNKEGFTKNNCPQCNSQNRSNNFISNRNRQLKVEKEEGSDNFYSFKLVLDYILAQSNDSECPYVEVDILEISNVQAINPECDEYDFSSTSDKWYKKMCNNVNKNPLKFVRWRLANNKLYKYIDQDFPSLRDDCEYWKLVVPKDFRDKILQRCHDSCVSGHLGIYKTFHRVSRLFYWPFMKMDITKYIRKCEVCLRTKPEQKSPAGHMGQAVEPTKPWEIISMDLFGPLPRSSAGNTWILVVTDKFSKFPLLFPLRKATATSISKILKENVFLLFGVPRVLKCDNGSQFKGNILRSFCQEFGIRFLFTPNFTPHPNPTERINRIMKTMLMAYVKDNHRLWDVNLPELGCAIRTAKHEVTGQTPYFINFGCEMMTHGSEYHLKIGNEENKQRVYDRSKNMNRLRDWVKKRIDKASDNTRERYNLRRRDVHFKENDLVWKKNYVLSDKANYFTSKFADRFVGPFRVKRKVGYCTYELINDNGKSIGHWHVKDLKPHPQNSDSHVESDSDVDSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F286</accession>
    <name>A0A6P7F286_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger protein 501-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114325545</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129466.1">
        <property type="nucleotide sequence ID" value="XM_028273665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F286"/>
    <dbReference type="FunCoup" id="A0A6P7F286">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273665.2">
        <property type="protein sequence ID" value="XP_028129466.1"/>
        <property type="gene ID" value="LOC114325545"/>
    </dbReference>
    <dbReference type="GeneID" id="114325545"/>
    <dbReference type="KEGG" id="dvv:114325545"/>
    <dbReference type="InParanoid" id="A0A6P7F286"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002104">
        <property type="entry name" value="Si:ch211-266d19.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028129466.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56683" checksum="D2B3BBD54F54C508" modified="2020-12-02" version="1">MEEELDFQKICRVCLNEGVMMSIFKVNISKKLMACASIQVWQYDGLPTQICQKCSAKLHISFQFKKLCEKSDGKLRQQLNKINERQAQQQQQQQQLQQQNPPIQTVEKQSTPNLPQYTQPIPENSCVFIECNPIIDSIGHENNFIPPSQPEQQITQLDYNQLGGYNVDSVGNVQVYNGSYNMSLEHTGVLHNQEIQSLQLDPQPQQPQIQYLNPPPNHQLTNLSNSTNNVKDEVEKTKVNQSPTPVDTSKQCPTCNKIFSTMTKLTRHMKTHASDLPYKCKICNKGFAHSGNFKIHLRMHTGERPFRCVVCDKGCRQAQDLEKHMRTHTGERPHKCAMCPKAFSTRSNLIAHIRIHTGERPYVCCVCQKSFCQSNELTKHMRTHTGEKSHICDICNKGFNGSSTLIVHRRSHTGERPYVCLVCNKAFTQNSCLATHMKRHNTNSQCDNNVNTNSTREQDTSNNPKETFTCTFCSSSFESSTEYNEHLKTHSTPSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F546</accession>
    <name>A0A6P7F546_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114324882</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128580.1">
        <property type="nucleotide sequence ID" value="XM_028272779.1"/>
    </dbReference>
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    <dbReference type="EnsemblMetazoa" id="XM_028272779.2">
        <property type="protein sequence ID" value="XP_028128580.1"/>
        <property type="gene ID" value="LOC114324882"/>
    </dbReference>
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    <dbReference type="KEGG" id="dvv:114324882"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
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        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028128580.1"/>
        </source>
    </evidence>
    <sequence length="79" mass="8173" checksum="DF3CD73F92E129C0" modified="2020-12-02" version="1">MFKRGRGGSAGAKFRISLALPVGAVTNCADNTGAKNLYVSAVQDIGGRLNRLPAAGSGGMIVATVKKDKPELRKKSCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F6H4</accession>
    <name>A0A6P7F6H4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyisourate hydrolase</fullName>
            <ecNumber evidence="5">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114325470</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028129353.1">
        <property type="nucleotide sequence ID" value="XM_028273552.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050519516.1">
        <property type="nucleotide sequence ID" value="XM_050663559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F6H4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028273552.2">
        <property type="protein sequence ID" value="XP_028129353.1"/>
        <property type="gene ID" value="LOC114325470"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663559.1">
        <property type="protein sequence ID" value="XP_050519516.1"/>
        <property type="gene ID" value="LOC114325470"/>
    </dbReference>
    <dbReference type="GeneID" id="114325470"/>
    <dbReference type="KEGG" id="dvv:114325470"/>
    <dbReference type="InParanoid" id="A0A6P7F6H4"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028129353.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31938" checksum="0C2E235CED0D7DAA" modified="2020-12-02" version="1">METEEVEVVEVNKVNQEDTEYFIPVLLPTSSTKPTLSIHSRGKYYKQTYRAAWEHMPDFKGWLKGVEGEPTRAYCTYCHKNLHAHMNSLLKHTCTIRHQKAAQLNSARKSKIAINMKESISGNEDDKDVSNEESELEEEDDERSRELKPISESTADQNVEIKLFPEKPPISTQVMDMTKGKPISGLQVSLYKLIDGRWTFVNEGMTNSTGKFSEFMDRPDFTNGRYKLHYDVDRYFEAKKQETIYPFIEIIFNAGCTESHHIPLLLSPFGYTTYKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCR4</accession>
    <name>A0A6P7FCR4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide-binding protein G(O) subunit alpha isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114326943</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028131218.1">
        <property type="nucleotide sequence ID" value="XM_028275417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCR4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028275417.2">
        <property type="protein sequence ID" value="XP_028131218.1"/>
        <property type="gene ID" value="LOC114326943"/>
    </dbReference>
    <dbReference type="GeneID" id="114326943"/>
    <dbReference type="KEGG" id="dvv:114326943"/>
    <dbReference type="CTD" id="36104"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032291">
        <property type="term" value="P:axon ensheathment in central nervous system"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007419">
        <property type="term" value="P:ventral cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028131218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028131218.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40673" checksum="BB7BED73DD135E90" modified="2020-12-02" version="1">MGCTVSAEERAAIARTKQIDETLKEEKQRSRRDVKLLLLGAGESGKSTIVKQMKIIHESGFTPEDHKQYRPVVYSNTIQSLVAILRSMPNLGISYGNNEREIDGKMVFDVIQRMEDTEPFSEELLAAMKRLWADSGVQECFGRSNEYQLNDSAKYFLDDLNRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYAGAQEYGEAAAYIQAQFEAKNKSTTKEIYCHMTCATDTHNIQFVFDAVTDVIIANNLRNCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FCY4</accession>
    <name>A0A6P7FCY4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114328781</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133541.1">
        <property type="nucleotide sequence ID" value="XM_028277740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FCY4"/>
    <dbReference type="FunCoup" id="A0A6P7FCY4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277740.2">
        <property type="protein sequence ID" value="XP_028133541.1"/>
        <property type="gene ID" value="LOC114328781"/>
    </dbReference>
    <dbReference type="GeneID" id="114328781"/>
    <dbReference type="KEGG" id="dvv:114328781"/>
    <dbReference type="InParanoid" id="A0A6P7FCY4"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052320">
        <property type="entry name" value="Cytochrome_b5_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281:SF0">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="11">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028133541.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="29290" checksum="467AEB5439D2C8FD" modified="2020-12-02" version="1">MNNDDDQLDKKWTYYAPFEVVIHNTPEDCWVSFLGKVFDVTPIVERHRNERCVLPLLAMAGKDITQWFDEATGDIQHYVHPETGCRVPYCPHGPIPDVSVQVPATDWKPLDRPPWWMDEQYQIGLLTKRVRPLRVVNMVAPFFKEVLINVCCEDNFYRIQERYNLFNSDAGSYTWRYKSKNIDMNKTMEENGILDERDTFTRLGLPQNYYVPSVFLYYNDDLKYCDFDDDECEPLPSDFGLCCMKSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FEW3</accession>
    <name>A0A6P7FEW3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114328664</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114328664</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133382.1">
        <property type="nucleotide sequence ID" value="XM_028277581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050509868.1">
        <property type="nucleotide sequence ID" value="XM_050653911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FEW3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050653911.1">
        <property type="protein sequence ID" value="XP_050509868.1"/>
        <property type="gene ID" value="LOC114328664"/>
    </dbReference>
    <dbReference type="GeneID" id="114328664"/>
    <dbReference type="KEGG" id="dvv:114328664"/>
    <dbReference type="InParanoid" id="A0A6P7FEW3"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028051491" evidence="2">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028133382.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39507" checksum="9E8C8F7B2FEFFCEE" modified="2020-12-02" version="1">MKTVLYLSCLISLVFVHSEVINPQSKNYTIIDYASSYSIPVWYVYSSKVSFTSSILYQKGQKQHEDMIYCTKFNTSQLCSCLKTYLGNPDTAHFRKPVQDKQVAVVDMAQSVIRLNSGTVCNYHKGKCQDPKINSSVGVCWEYKKHKIHTQRYMVEEYNINSNTFLVFDYEGTRTTLQLLYFNKNSSLIWCTNRLDMVVFKGSYEDFENYSIANTSRRNFKCFPKKLVSNDRNTESKSENNNIDTGTMYERINSQKFQQLSESFWVIKFVCVPVIVALILLHMILSCLQFKTLNELKNGNNVKQAKISENSNRKVNKNQTNTKEAYYESVDYDAINRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FG55</accession>
    <name>A0A6P7FG55_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC114329078</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114329078</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133892.1">
        <property type="nucleotide sequence ID" value="XM_028278091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FG55"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278091.2">
        <property type="protein sequence ID" value="XP_028133892.1"/>
        <property type="gene ID" value="LOC114329078"/>
    </dbReference>
    <dbReference type="GeneID" id="114329078"/>
    <dbReference type="KEGG" id="dvv:114329078"/>
    <dbReference type="InParanoid" id="A0A6P7FG55"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028133892.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26245" checksum="8159D7EB9C3B8D7B" modified="2020-12-02" version="1">MSKYSENEDDPYESSGDEWKEEEEVKKNSRRSSQRLSKKPRMTVVEYGSSDDSDSEPARKKSKNGVTKKAKVQEEDEDDDDYSAEEDEDEEIKEETEKVKNSGTKATSGTTGSPVPAVRQMGNRKFIPKTLYSEDYTTGSFVILKKDAEGDASKHPCIWRIDGKALLQKYEAYDEDGKVRHKNTSIYTGWSPMDKDLYAPVTVDVIQHNNQNLRVELHWDKLKDINADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FGZ4</accession>
    <name>A0A6P7FGZ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114330198</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135324.1">
        <property type="nucleotide sequence ID" value="XM_028279523.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503753.1">
        <property type="nucleotide sequence ID" value="XM_050647796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FGZ4"/>
    <dbReference type="FunCoup" id="A0A6P7FGZ4">
        <property type="interactions" value="1762"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647796.1">
        <property type="protein sequence ID" value="XP_050503753.1"/>
        <property type="gene ID" value="LOC114330198"/>
    </dbReference>
    <dbReference type="GeneID" id="114330198"/>
    <dbReference type="KEGG" id="dvv:114330198"/>
    <dbReference type="CTD" id="34430"/>
    <dbReference type="InParanoid" id="A0A6P7FGZ4"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000007">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="15">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028135324.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34738" checksum="23683BC2BEED5403" modified="2020-12-02" version="1">MMASTSRYDANKVCCSSHPDAPLIEDYRAGDQICSECGLVVGDRVIDVGSEWRTFSNDKNGTDPSRVGGPENPLLGGSDLTTIIGPGRGDASFDTFGVSRYQNRRTMNSSDRALINAFKEINAMADRINLPRTIVDRANNLFKQVHDGRNLKGRSNDAIASACLYIACRQEGVPRTFKEICAVSKISKREIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPNMVQRAATHIARRAVEMDIVPGRSPISVAAAAIYMASQASEDKRSQKEIGDIAGVADVTIRQSYKLMYPHAVNLFPQDFKFATPIEQLPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FHF0</accession>
    <name>A0A6P7FHF0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC114329448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC114329448</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="3">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028134362.1">
        <property type="nucleotide sequence ID" value="XM_028278561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FHF0"/>
    <dbReference type="EnsemblMetazoa" id="XM_028278561.2">
        <property type="protein sequence ID" value="XP_028134362.1"/>
        <property type="gene ID" value="LOC114329448"/>
    </dbReference>
    <dbReference type="GeneID" id="114329448"/>
    <dbReference type="KEGG" id="dvv:114329448"/>
    <dbReference type="InParanoid" id="A0A6P7FHF0"/>
    <dbReference type="OrthoDB" id="5538672at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_028134362.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="22951" checksum="7292CC388E096783" modified="2020-12-02" version="1">MGSNKQNILKHSEVHKEIIAHPPKIRSDEDKMGPYNRYNDENREIYLEKKRMFEEACHKYAKMNADTVNTYKIRLHENYIEGLDLCFLDNRNSKHGAPITSSGLLLKKRTERRAHEIPAQDHQIPCNVEPWFRKYLILNKFIWAARITIIKNRLLRNLNLLSRLDRESVKQYEIVRKPYFGSYKDIFEKFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FI98</accession>
    <name>A0A6P7FI98_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114330621</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135819.1">
        <property type="nucleotide sequence ID" value="XM_028280018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FI98"/>
    <dbReference type="FunCoup" id="A0A6P7FI98">
        <property type="interactions" value="1823"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280018.2">
        <property type="protein sequence ID" value="XP_028135819.1"/>
        <property type="gene ID" value="LOC114330621"/>
    </dbReference>
    <dbReference type="GeneID" id="114330621"/>
    <dbReference type="KEGG" id="dvv:114330621"/>
    <dbReference type="CTD" id="3420"/>
    <dbReference type="InParanoid" id="A0A6P7FI98"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="40"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028135819.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="41051" checksum="3AE2B362C063B678" modified="2020-12-02" version="1">MAVTTRNVPRLLVQALQILPRTSTRGLSSGMAERPDARTTCTLIPGDGVGPELMYSVTEVFKAAGIPVDFDTYFFSEVNPTLSAPLEKVADSISRNRVCLKGILATPDYSHTGELQTLNMKLRNALDLYANVVHVRSLPGVKSRHSNIDCVIIREQTEGEYSALEHEGVKGVVECLKIVTAKKSQRIAKFAFDYATKNNRKKVTAVHKANIMKLGDGLFLRSCEEMAKLYPKIEFERMIVDNCTMQMVSNPQQFDVMVTPNLYGNIVDNLASGLVGGAGVVAGASYSANCVVFEPGARHTYSEAVGKNVANPTAMLLCASKMLRHVNLPLYGEMIRAAIEKVLKDGKIKTKDVGGQSTTQQFTYAVISNLEIPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKY9</accession>
    <name>A0A6P7FKY9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114330519</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028135667.1">
        <property type="nucleotide sequence ID" value="XM_028279866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKY9"/>
    <dbReference type="FunCoup" id="A0A6P7FKY9">
        <property type="interactions" value="2288"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028279866.1">
        <property type="protein sequence ID" value="XP_028135667.1"/>
        <property type="gene ID" value="LOC114330519"/>
    </dbReference>
    <dbReference type="GeneID" id="114330519"/>
    <dbReference type="KEGG" id="dvv:114330519"/>
    <dbReference type="CTD" id="31683"/>
    <dbReference type="InParanoid" id="A0A6P7FKY9"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028135667.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="57897" checksum="4E0759FC1F1AC9B2" modified="2020-12-02" version="1">MVVVCRTGHLIKSSKTVTKSPNLFFSTYRPPYKNSSNFLRRNVLGRASNSLVDSYCGCRYFSVDYFQSSDNRTTVSKLTPQEVDDILRANEYTHEFPKGPVKSYDSNQLASNNPIEDTRSEASCLLTSGFLFGVFDGHGGSACAQVIAKRLYHYLAACLLPYDSLVKYIKSLLGSQPQELIQSYNDKVEFVDDIRQLYSDSFAKFLKDLSEKGPVSNAELQPAIEQAFARLDKDISDEAIPKENEPLNLKTMSVAMSGAVVCVAHIDGPHLHIANVGDCCAVLGTLSESNSWVANKLTVEHNTYNQPEVDRIIKEHPYNEALSVIRMDRLLGHLAPLRAMGDFRFKWSLEIMNNVIVKHFGKHIVIPNYHTPPYLSSVPEITRHRLTPNDKFLIIGTDGLWDMMTPLQAVRLVGEHMKGKVTLNPLKLPRKNMTMNEINELLLQRKEGLKTKPRDSNAATHLIRNALGGTEFGIDHTKLTQLLTLPEDVVRVFRDDITVSIIYFDSEYLRHCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKZ4</accession>
    <name>A0A6P7FKZ4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Odorant receptor 43a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114331457</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028136844.1">
        <property type="nucleotide sequence ID" value="XM_028281043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FKZ4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281043.1">
        <property type="protein sequence ID" value="XP_028136844.1"/>
        <property type="gene ID" value="LOC114331457"/>
    </dbReference>
    <dbReference type="GeneID" id="114331457"/>
    <dbReference type="KEGG" id="dvv:114331457"/>
    <dbReference type="InParanoid" id="A0A6P7FKZ4"/>
    <dbReference type="OrthoDB" id="6764485at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028136844.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22781" checksum="0A6359C8345CAFA6" modified="2020-12-02" version="1">MVTGYLYSIPSLIFLYVTCNVQFRYEVLNELMENLLEEGEMEDADFQRKIFSNLKLCIMVHNQNKRLACRMLDLTGGFTLCLCLLSIVSFAALSFFVLTNISPKSNIRILVSLIVNIITLLILCEMSDKLYVVSTKLFENGINCPWWNWNKENRKILLIFLINASKPIRINGFNIIDANYALILRVTINIISVNTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FQQ2</accession>
    <name>A0A6P7FQQ2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase SUV3 homolog, mitochondrial</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC114332971</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Major helicase player in mitochondrial RNA metabolism and maintenance. Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_028138581.1">
        <property type="nucleotide sequence ID" value="XM_028282780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FQQ2"/>
    <dbReference type="FunCoup" id="A0A6P7FQQ2">
        <property type="interactions" value="1814"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282780.2">
        <property type="protein sequence ID" value="XP_028138581.1"/>
        <property type="gene ID" value="LOC114332971"/>
    </dbReference>
    <dbReference type="GeneID" id="114332971"/>
    <dbReference type="KEGG" id="dvv:114332971"/>
    <dbReference type="InParanoid" id="A0A6P7FQQ2"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.140:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000446">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041453">
        <property type="entry name" value="Suv3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18114">
        <property type="entry name" value="Suv3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="342"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028138581.1"/>
        </source>
    </evidence>
    <sequence length="754" mass="84807" checksum="6A24CC7C6F8AF511" modified="2020-12-02" version="1">MLQNTSKVRNLCATVRGLKLSKLFKDNDAKCVLGYLQTRHKKDDSSLSSLFVPVQIKPSADDINVGAELTGTLNKTDLLKVLNKFYQKKEIKALLVDNGLDQYLQHQAYVSFRRYCLEAQNLPADIHVVFSDILQGAGNITDIFPYFLRHAKMMFPHLDCMDDLRKISDLRSPANWYPEARAINRKIIFHSGPTNSGKTYHALERFMTSKSGVYCGPLKLLASEVFNKSNNRGTPCDLVTGEERNFADPAGNASNHVSCTVEMTSVTNAYEVAVIDEIQMIKDVQRGWAWTRALLGLKAEEIHLCGEAGAVDLVRQICLTTGEDLEVRNYKRLTPLKIENTAVGSLENVLPGDCIVCFSKNDIYSVSRGIEATGKEVAVIYGGLPPGTKLAQAAKFNDPENSCKILVATDAIGMGLNLSIKRVIFYSLIKATMNEKGEREMDTISVSSALQIAGRAGRYGTQWPEGSATTFKSEDLPTLQNLLASQPDPIIQAGLHPTAEQIELYAYHLPNSTLSNLMDIFINLSTVDDSLYFMCQTEDFKFLADMIQHVPLPLRARYLFCCAPINKKMPFVCTMFLKFARQYSKNEMITFDWLCRNIGWPLQPPRTILDLVHLEAVFDVLDLYLWLSYRFVDLFNEPNLVRDMQRELDQIIQQGIVQLTRLLRNSETGISSGTGAADDEEFAMSRQKQTYLRGQKSLTLGKGKLTERLLAQGILTPTMLQELKKEWNKGSVTNIVKEEVEEPKKTRRKRTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FWN8</accession>
    <name>A0A6P7FWN8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114334996</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140944.1">
        <property type="nucleotide sequence ID" value="XM_028285143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FWN8"/>
    <dbReference type="FunCoup" id="A0A6P7FWN8">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662841.1">
        <property type="protein sequence ID" value="XP_050518798.1"/>
        <property type="gene ID" value="LOC126892925"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FWN8"/>
    <dbReference type="OrthoDB" id="2018427at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="13">
        <location>
            <begin position="38"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="129"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="657"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028140944.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="102257" checksum="1934744361D2DB59" modified="2020-12-02" version="1">MASSSVARTSKYSYRSTGAAGGSADVSIEYSADLTALSRLEDKIRLLQDDLEIERELRSRIEREKADLSVQVIQLSERLEEAEGGAESQFEINKKRDTELLKLRKLLEDVHIESEETALILKKKHQEIVVDFQEQIDSLAKAKSRAEKEKGKFQAEIYQLIAQVESVTKERLISIKQCEKLEITVNELNIRIEELNRSVVDITSHKTRLSQENIELIKEVQDLKVNIENAIYLKSQLAGQLEDARRRAEDDERRRSLLEANLHQVEIELESVRVQLEEESEARLDLERQLVKSQGEVQVYKSKYETEVVARAEEVEEIRRKFTIRIQEQEEHIEALLVKVNNLEKQKSRLQSEVEVLIIDLEKANNTARELQKRVEQLERINIDLKTRLDETVQLYEQSQRDLRNKVTELQRAVHELDKTRELKDQLARENKKLCDDLSDSKITITELTRRLHELDLEVRRLENERDELTAAYKEAEAGRKAEEQRAQRLAAELGQFRHEAEKRLQEKDEEIEAIRKATSIEIEQLNARVVEAETRLKTEVTRIKKKLQIQITELEMSLDSANKLNIDLQKTIKKQSLQLTEIQAHYDEIQRQLQVTLDQLSVSQRRVQALTAESEEIRSNYEGALRGKRQAEQMYEEAGTRINELTTINVNLSSMKVKIEQELSSVLADYDEITKELRISDERYQRVQAELKHTVEILHEEQERVVKIEAIKKSLEIEVKNLSVRLEEVEANAIVGGKRIISKLEARIRDCEAELDEEKRRHAETIKILRKKERTVKEVMIQCEEDQKNIALLQETLDKANSKITIFKRQLQEVEGVSSQSITRVRRFQRELEAAEDRAETAESNLSLIRAKHRTFVTTSTVPGSQVYLVQEQRASSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYA9</accession>
    <name>A0A6P7FYA9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baculoviral IAP repeat-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114332238</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137798.1">
        <property type="nucleotide sequence ID" value="XM_028281997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYA9"/>
    <dbReference type="FunCoup" id="A0A6P7FYA9">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281997.2">
        <property type="protein sequence ID" value="XP_028137798.1"/>
        <property type="gene ID" value="LOC114332238"/>
    </dbReference>
    <dbReference type="GeneID" id="114332238"/>
    <dbReference type="KEGG" id="dvv:114332238"/>
    <dbReference type="InParanoid" id="A0A6P7FYA9"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028137798.1"/>
        </source>
    </evidence>
    <sequence length="138" mass="16371" checksum="26C4E3286C5358F8" modified="2020-12-02" version="1">MSLIEDIEEYLPYLHEENRLKTYKTWVFSKNKPCNVDKMAEAGFIFIGNKQEPDAVKCFFCWKNLDGWEESDNPWKEHLKHAPVCSFAKLQQAQTNITLKQFIDLRHELLSKIVKYYKDIEISELTSIVKKVESRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G162</accession>
    <name>A0A6P7G162_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Putative inorganic phosphate cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114336430</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May be an inorganic phosphate cotransporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142596.1">
        <property type="nucleotide sequence ID" value="XM_028286795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G162"/>
    <dbReference type="EnsemblMetazoa" id="XM_028286795.2">
        <property type="protein sequence ID" value="XP_028142596.1"/>
        <property type="gene ID" value="LOC114336430"/>
    </dbReference>
    <dbReference type="GeneID" id="114336430"/>
    <dbReference type="KEGG" id="dvv:114336430"/>
    <dbReference type="InParanoid" id="A0A6P7G162"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000144">
        <property type="entry name" value="Picot, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028142596.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55363" checksum="9EC7E971F8D6291B" modified="2020-12-02" version="1">MIHFSWDEIFTKIKTYFDCSWLGVRHIQYVMLFVVVNICYAVRSILSIAIFAMTAEDPPDKSIPTYPEWVPYKNIMLSSFFWGYICLQIVAGILIKRYGPKWFLGGAIFIGCLFCCLIPLLGARMGYGGVIFCRIVTGLTQGFLFPSIHCLLSSWTPLQDRAKFGTFVYAGGPLGNVISMPIAGFISNSHLGWPAVFYLFGALGIVWSVVWFIIGSDSPSKHKSISEEEVQYIEQNTEPRDKEEKVEPTPWKAILTSMPVWAILVSHCGQNFGFWTLLTEIPSYMHQILNFDLKSNSTLSSLPYLTNWILSLFMSPIADFIIIKKYANVGQSRKIFNTIGLWIPALALISLTFVDSDNRVAAIILLTIAVGFNSAVYSGYNVNHLDISPVHAGTLMALTNSVSNIFSLISPLVVDAIIAITGYQENQKQLWTFVFCIAAGIYILCGCFYDLFASGEVQSWNTSGTSSVDPESQKPEKQQEAEVFEDIQLGKVENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1U0</accession>
    <name>A0A6P7G1U0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein ECT2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114336676</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142836.1">
        <property type="nucleotide sequence ID" value="XM_028287035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G1U0"/>
    <dbReference type="FunCoup" id="A0A6P7G1U0">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644367.1">
        <property type="protein sequence ID" value="XP_050500324.1"/>
        <property type="gene ID" value="LOC126880490"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7G1U0"/>
    <dbReference type="OrthoDB" id="9997817at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17733">
        <property type="entry name" value="BRCT_Ect2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01229">
        <property type="entry name" value="PH_Ect2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049396">
        <property type="entry name" value="ECT2_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21243">
        <property type="entry name" value="ECT2_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="656"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028142836.1"/>
        </source>
    </evidence>
    <sequence length="1139" mass="127315" checksum="F0B5C132C21FD72C" modified="2020-12-02" version="1">MDEVGAPKIIHNQGSVCSDSNGDDVSRNDVSSQSNLRLCLVGSVASDSDVYNVAQSFALPIVTSKDGQEYTQDDSCTTIYVVKEFDGDVFNVLFKSKQQLLGSVALKQLAVKKEKIPCNTRPLYNLAMTGVIVCFTGFREKEELAKLVTLLHHMGGSIRKDMSSKVTHLIANTSGGDKYQYAATFRVPVMNPSWVVDSWQRRDDLNFTGIMEEHVAKHKLKPFHGARVGFVGFAEEEEKHMSEVLLLNGGVVTSVDDVNCTHVVMEHAEIYTLEAASAPLSPKVSSPPSRSKTPRTPSYSNVANSNMSLSNCFKVNQSLACLETLHENSGDNNLEDFDIGFDQSFDPNLTPHKRKRKFNSPEQSSILVKRKRDKSYSERKRKVSEFFKTPINYFSNRRRTIDASSLNQSLSESVISSSGIFNVETVQNLSSYNDNTPQNSKKGPKKNLFTRTFSSSKFRRTKKSIDLNATKLSFGEACDVEGREKLNATCFPDISLNPITTNTYELSSEHARASRRTSVSAVAVVDESTVTERPEAPSKVWIVKAEWFWTSVQKETSLPEKDYLFDDYLDQVLSPSGRRDSSATPGSAARRRKRKLLLSSLVHNQSPALTKRRSSVSDAGLLSVSGSFLDCTTSPNKEIIDGTEPVIDTPRKGLTQRHQVFLELLQTETNYVDILHTIVTMFKKHLEEMPEQEALLNNTELNLIFGKLPFIYETHIKMLDEIRWTAAHWSEDLSIGNIIVKYSSELQRAYPPFINYFEEMKEVLCQCDQNKPRFHAFLKACQTRAECGRQSLQELMIRPVQRLGSISLLLNDILKNTPKTNPDHSALEQALAALREVMTHINEDKRKAEGQVTLFNIFNDIDNCPPDIVSSHRNFVAKAEVVQLSSSEGLASKGNNLVLFLFSDQLEVCKKKSKAFNSLKSPSTVTTAGVGGSLQNRQLIKPYKHIRLMALNTIKRVIDIKETEECQKVFSLVCRNNDDLKEKLYSFAIADEEADKVQFLKTLTRQMANNACTADADKFMAYLEPQQLDIDTSDVNNGTFSKAIKFATNRFKVGRAFSFNKTPSKLKRAVSSMMSPFGSSTNLTPASQLAQMKLASYSNINELGNAENSNESQPVAPMSVQPTRKMKSSSLGSNALKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2R4</accession>
    <name>A0A6P7G2R4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114333223</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028138885.1">
        <property type="nucleotide sequence ID" value="XM_028283084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2R4"/>
    <dbReference type="FunCoup" id="A0A6P7G2R4">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283084.2">
        <property type="protein sequence ID" value="XP_028138885.1"/>
        <property type="gene ID" value="LOC114333223"/>
    </dbReference>
    <dbReference type="GeneID" id="114333223"/>
    <dbReference type="KEGG" id="dvv:114333223"/>
    <dbReference type="CTD" id="34284"/>
    <dbReference type="InParanoid" id="A0A6P7G2R4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028138885.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40654" checksum="1C1FD7BA898D773F" modified="2020-12-02" version="1">MGNNAATANKKVDSAESVKEFLDQAKEDFEEKWKRNPTNTASLDDFERIKTLGTGSFGRVMIVQHKPTKEYYAMKILDKQKVVKLKQVEHTLNEKRILQAISFPFLVSLKFHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKGHKWFASTDWISTFQKKIEAPFIPRCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G5Z2</accession>
    <name>A0A6P7G5Z2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cathepsin L-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114338070</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144459.1">
        <property type="nucleotide sequence ID" value="XM_028288658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G5Z2"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288658.2">
        <property type="protein sequence ID" value="XP_028144459.1"/>
        <property type="gene ID" value="LOC114338070"/>
    </dbReference>
    <dbReference type="GeneID" id="114338070"/>
    <dbReference type="KEGG" id="dvv:114338070"/>
    <dbReference type="InParanoid" id="A0A6P7G5Z2"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028350805" evidence="2">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="139"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028144459.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41489" checksum="87007AD774EC8A6A" modified="2020-12-02" version="1">MKRIVVILILFFVAANCEYQEWEKFKTKYSKVYATLEEESQRFAIFQENLKLIQEHNVKYEKHETSFTMEITRFSDKSYKELTRRFEEFNIDNFDDAETTTSNDVLESTTSRSPIPHYCNNESIYPYRHFKNFEDDDDVPESVDLRLKGYVLPPRDMGDLEEHWAFSISSAMEIETAWHNLTYEYLSTQFLIDCTESYQEAYNQMYYDGIPNEIDYPFKNGKGECKPICKGRCLNHHYLSSEDLIKKTIALLAPVTVYFDGGDLPFYKQGIIDGSNCPRSFIPHPSTWRKPWSAVIIGYGNDGSDGSGTDYWILKNSWGDSWGEEGYFKLIRGKEACGMMRLPIWPSLQEPNGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G6H5</accession>
    <name>A0A6P7G6H5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesol dehydrogenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114334272</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140115.1">
        <property type="nucleotide sequence ID" value="XM_028284314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G6H5"/>
    <dbReference type="EnsemblMetazoa" id="XM_028284314.2">
        <property type="protein sequence ID" value="XP_028140115.1"/>
        <property type="gene ID" value="LOC114334272"/>
    </dbReference>
    <dbReference type="GeneID" id="114334272"/>
    <dbReference type="KEGG" id="dvv:114334272"/>
    <dbReference type="InParanoid" id="A0A6P7G6H5"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028140115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028140115.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27472" checksum="E885D6DDE64EE083" modified="2020-12-02" version="1">MDRWLGKVALVTGASAGVGAAISEKLVEAGLKVVGVARRKNVLDELAQKLSSKKGKFFPYTGDVSKEENIVKAFSWTKENVGPVSVLINNAAVLLLEDLISITTQHLKQEFDINVISVCIANREAIKQMRENNIAGHIININSVAGHKVITVPKLNVYSATKHAVSALTETLRLEQSNQKTNIKVTSISPGAIVTEMMMNVSKEMGMPIEKPKEIEKVAALSAKDVADSVYYVLSTPPHVNITELTIQVVGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GAT8</accession>
    <name>A0A6P7GAT8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin L-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114337606</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143897.1">
        <property type="nucleotide sequence ID" value="XM_028288096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GAT8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028288096.2">
        <property type="protein sequence ID" value="XP_028143897.1"/>
        <property type="gene ID" value="LOC114337606"/>
    </dbReference>
    <dbReference type="GeneID" id="114337606"/>
    <dbReference type="KEGG" id="dvv:114337606"/>
    <dbReference type="InParanoid" id="A0A6P7GAT8"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028145624" evidence="7">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="111"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028143897.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34819" checksum="530E3EBF7310C087" modified="2020-12-02" version="1">MKLLILAATLIVAINANLSAFEQWTSFKATHNKFYNVIEDKLRFAVFQENLRKIDAHNAKYEKGEETYYMAVNKFADWSSAEFQAMLDRQMANKPKQSFIAKHVVDPNVQAVEEVDWRESAVLGVKDQGQCGSCWAFSTTGSLEGQLAIHKNQRVPLSEQELVDCDKVNDGCDGGLMTDAFFYIEHHGLSSEEQYPYTGVDGHCNHVKDKQVSSISGYVELDETESALADALANVGPVSIAVEADTWQFYSGGVFNNKNCGDALNHGVLAVGYTKDVFIVKNSWGTGWGEQGYIRVARGSNLCGINLMNSYPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GCG9</accession>
    <name>A0A6P7GCG9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC114335905</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141990.1">
        <property type="nucleotide sequence ID" value="XM_028286189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GCG9"/>
    <dbReference type="FunCoup" id="A0A6P7GCG9">
        <property type="interactions" value="1333"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286190.2">
        <property type="protein sequence ID" value="XP_028141991.2"/>
        <property type="gene ID" value="LOC114335906"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GCG9"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141991.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_028141990.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13278" checksum="BABC023198EEE97D" modified="2020-12-02" version="1">MSLESIPRDLRGLRACLVCSLIKSFDQFEKEGCENCEEFLRMKNSHDNVYDCTSNNFDGMISVMCPDDSWVAKWQRISRLSRGVYAISVSGTLPKSIIKDLKSRGINYKSRDTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIL3</accession>
    <name>A0A6P7GIL3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MATH and LRR domain-containing protein PFE0570w-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114339344</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028145777.1">
        <property type="nucleotide sequence ID" value="XM_028289976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIL3"/>
    <dbReference type="EnsemblMetazoa" id="XM_050641819.1">
        <property type="protein sequence ID" value="XP_050497776.1"/>
        <property type="gene ID" value="LOC126878936"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GIL3"/>
    <dbReference type="OrthoDB" id="10497326at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028252728" evidence="2">
        <location>
            <begin position="21"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028145777.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="82111" checksum="793D5271D290FFA6" modified="2020-12-02" version="1">MKFNVLIIIYLVCQCAFIRGRKIKNLKKIISKINYIPKEADPIEDWISSDEPFLESSEEVEISEFVFQNPEHVKSLYKPVNWNAHYVPFKYPSSSYGSIDKSIASAYQVRPENVFNLISALEISKIRKYPENFKKLLKVLLKICQSESVDNNSKLSTMYTILKAFNHSPPSENLVDIILKIIKILSKHSNFNASYKFSKTSASVKDISNIILKIIELSKKNSDVTDPLGVIIPIIETLPNTYQEQIFKNLLTPDQRFTSEILPSPYLSSKNDYNLLPQLVLKLYHQKPKRFKTLSHIISLLADSDLVKYNENSNNVIQFVLRQLSLSGIDSLVYRLGHTTLSPTNVNFVITSFFKNVQKMLSDKKHFSKNKTLAKSKNKILTKSDNFQSEKDWSESAENRIGSGDHSIHKGTKEKSENLKILKKAKHKKTSTNSKNKKKLKKHGKPKKSQKDSAELHLSFYESPNKDTNKTLGKSENLKILKKDKHKKKYFIDNKKKKSPTEIENSISQKDTAESSYPIHNESAENTLKKPVKKDSTKAHSSSSSSDYKDTTNKMLKKGEHKKTLENTKNEKPWTTSDNSKSKKDLGKFIKPGFNDLHNYFNINERFYPFQIITGPQHHPGNYKPVSNNLWTNKQLDNNNMFLQILKAVSDTANNSNPPIFDKNPELGSDITGLAPYNVIPCCLPAPVVLPSSLDTINPFEMRKNNAGSRKARYRTKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GIZ5</accession>
    <name>A0A6P7GIZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Septin-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114343279</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149891.1">
        <property type="nucleotide sequence ID" value="XM_028294090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GIZ5"/>
    <dbReference type="FunCoup" id="A0A6P7GIZ5">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294090.2">
        <property type="protein sequence ID" value="XP_028149891.1"/>
        <property type="gene ID" value="LOC114343279"/>
    </dbReference>
    <dbReference type="GeneID" id="114343279"/>
    <dbReference type="KEGG" id="dvv:114343279"/>
    <dbReference type="InParanoid" id="A0A6P7GIZ5"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="218"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="505"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028149891.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69606" checksum="D8CA050085ABFC5E" modified="2020-12-02" version="1">MSANNVNAQVPTTQATATIKSRPNIMPSSYMYTSSSALLNRSSENKPTPPPTLPKYTSSFNAGSSLNRDRDKDSVGGSYRLSSLDRVAMRQKFMDQQNNTTVTTTTTNGSPQTNGNGDAVSAATLQTKREMFFTSTENNSHSITSSLTKDSNRLNKTPSLEKPIDTSLKTLSPDSNRDDTSKESTPEIIKERPKPKELDGYVGFANLPNQVYRKAVKKGFEFTLMVVGESGLGKSTLINSMFLTDIYNSSDYPGPTQRLKKTVAVETTKVLLKENGVNLLLTVVDTPGFGDAVDNSNCWTPIIEFIESKYEDYLNSEARVTRKSMPDQRVHCCLYFIQPSGHGLKSLDIEFMKRLCDKVNIIPVIAKADTLTADECALFKKQILNEIAQNKIKIYEFPDTCEEDEEHKLNKSLKDRVPFAVVGANAVLEVDGKKLRGRKYPWGIAEVENLEHCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCCKLAGLGVDGKPSRISNKNPLAQMDEEKREHDLKMKKMEAEMEQVFEMKVREKKQKLKDSETELTRRHEATKKTLEMQAKELEEKRRQFEAEKEAWEKENQVTIEDLRRRSLEGSRETVDGKKEKKKKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GK76</accession>
    <name>A0A6P7GK76_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26 27 28 29 30" type="primary">LOC114343397</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26 27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25 26 27">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51308"/>
            <dbReference type="Rhea" id="RHEA-COMP:12953"/>
            <dbReference type="Rhea" id="RHEA-COMP:12956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.225"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mical family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.225" evidence="4"/>
    <dbReference type="RefSeq" id="XP_028150018.1">
        <property type="nucleotide sequence ID" value="XM_028294217.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150024.1">
        <property type="nucleotide sequence ID" value="XM_028294223.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150032.1">
        <property type="nucleotide sequence ID" value="XM_028294231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150040.1">
        <property type="nucleotide sequence ID" value="XM_028294239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150049.1">
        <property type="nucleotide sequence ID" value="XM_028294248.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028150054.1">
        <property type="nucleotide sequence ID" value="XM_028294253.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506886.1">
        <property type="nucleotide sequence ID" value="XM_050650929.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050506887.1">
        <property type="nucleotide sequence ID" value="XM_050650930.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294217.2">
        <property type="protein sequence ID" value="XP_028150018.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294223.2">
        <property type="protein sequence ID" value="XP_028150024.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294231.2">
        <property type="protein sequence ID" value="XP_028150032.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294239.2">
        <property type="protein sequence ID" value="XP_028150040.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294248.2">
        <property type="protein sequence ID" value="XP_028150049.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028294253.2">
        <property type="protein sequence ID" value="XP_028150054.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650929.1">
        <property type="protein sequence ID" value="XP_050506886.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650930.1">
        <property type="protein sequence ID" value="XP_050506887.1"/>
        <property type="gene ID" value="LOC114343397"/>
    </dbReference>
    <dbReference type="GeneID" id="114343397"/>
    <dbReference type="KEGG" id="dvv:114343397"/>
    <dbReference type="CTD" id="41225"/>
    <dbReference type="OrthoDB" id="20799at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120501">
        <property type="term" value="F:F-actin monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09439">
        <property type="entry name" value="LIM_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000004">
        <property type="entry name" value="protein-methionine sulfoxide oxidase MICAL2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057494">
        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF54">
        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25413">
        <property type="entry name" value="Rossman_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0440">LIM domain</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="3017"/>
            <end position="3039"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="20">
        <location>
            <begin position="526"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="21">
        <location>
            <begin position="1506"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="22">
        <location>
            <begin position="2859"/>
            <end position="3008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1210"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1572"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1614"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1649"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1769"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2040"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2582"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2711"/>
            <end position="2732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2796"/>
            <end position="2866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="2869"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1583"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1625"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1663"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1792"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="2814"/>
            <end position="2832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="2850"/>
            <end position="2866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028150018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_028150018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_028150024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_028150032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_028150040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_028150049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_028150054.1"/>
        </source>
    </evidence>
    <sequence length="3041" mass="346870" checksum="6543325254C66784" modified="2020-12-02" version="1">MDRSNQIVQHGVPVSSLDAAHANEYFEQFVNASSLKNILGYYRGLIDSLHLRPNVFNLFYPKLRANLTSWRAKALLKKFDSRASHKCYQKGKAAANTRVLVIGGGPCGMRTAIEAQLLGAKVVVVEKRDRFSRNNVLHLWPFVIEDLRMLGAKKFFGKFCAGAIDHISIRQLQCILLKVALLLGVEVHTEVSFETLVEPDANEKIGWRAQFKPANHPVSQYEFDVIIGADGKRNTLQGFSRKEFRGKLAIAITANFINKKTEAEARVEEISGVAFIFNQKFFKDLQEATRIDLENIVYYKDDTHYFVMTAKKHSLIEKGVIKQDFADTEKLLAPENVDKEALQQYAIEAATFSTNYQMPNLEFAVNHYGQPDIAMFDFTSMYAAENASKVVERNGYRLLKILVGDSLLEPFWPTGSGCARGFLSSLDAAWAIRSWSLGVASSLEVLAERESIYRLLAQTTPDNLNKDWKSYTLDPATRYPNFNKTVVLSHHVLALFDTDNPASIERMKRTSNEKVHDIPKKRRRGNLDNEVLLNWLTEQLKEVEGIEITEMGSVFKDGKVLCAIIHHYRPDLLEYSAIINNDAAKNNQIAINILEKDLGIPPVMTGSELTMTEDFLSMASYLTEIYDCFRGEIPHVKHPKLDLPIRPIKSMPPIIKNCVYIPQNDRQVKDQYKTCKKCFNAYYLRNRSSDCYYKNKLRKLVQTNLPVICVVDSKNKFQRPEPQNNLKPKKELYYKSNTVDLKNSEFLIPTRHKVLKNKKNKAKQVKLRVTDKNNNLITNNLVLEKKIIDRKRGMSEDDCLKPEIPISPRLDKQLKCIEKMYQKHERLKRVLTQLIRKRRSDGTSNNHHVLQTDYKVAQADAVGENVCSKVDQLTHVSELHVNINIDSQTPTSQIDLSDKLVKTNPEILPSVEQNKTGNISSRKDDVNTIFNNSHYQESSVYFSVKKPISETHLKIRILEKNRNKELTLQTIEYISSTNELKISSKIGLNHLSNETFSSPLLAQFSDQNLLFETLGRATSKTSRKNNSHDFDNGVSNQNCQLKLNGRKKIRAKTMIEGDGIHNQIFSRVSNWISSNDFFHQENKADTDAETIITNSRLTDITSVSKMDEYDGIVVEERTDVINFSNSKSEKSSEEKFVEKMKAFNSRAIKNLSKFSQYSPFQLAGALKSHSAPPTQFSVIVEGEELPDLPVANTKMSEVSFKTIKTSNIAHPITQPHRPSSRHKHKHTDMVTQKVGSVDRKPRKRRTMEKVGASVEERQKMLEEIASNRAERHNKRKYQRKLQTEQFIKSMQMLQANAKADAQPFEDYAIFLYRQTAPKFEDRVKQIEKQFTYVPDQENRPSQFNRGMGKDEDIAAKIKSLESKFGHRQSVDKKPKDLLRAIGKIETSDWNIKEIEKKILENKMGKPSRAIDKEKVPKWSKEQFLARQNKMEQKHLERQTSEEVKFAEFDQSIKNLDQKLKEGTARELGQNKVASITEKLVGKIPTEQKPPEKTNRQPALPTPNNSEFCHFCKKRVYLMERLSAEGRFFHHGCFKCQYCNVQLRLGSYTFDRDGLYGYRFFCLQHFGMVREESPAKVTRAPSTKRVDRSSPEKKSLGIAGVDLLDKVQTPERIEFSNLSSGHVSSDQEDSLNQIDEDEWTDKNFGASCAEMEDSDEASSSFSDPDSDDEGAYDDALEEPVTKEGTLKWAERWKNSYSRKKRNSHSDEYSSSDQSSYYDSSDVVKKLMSLTRFMRLRFLRCEESDTATEGEEDIRARELRKREVCVEPPIVHTDTGTDTEIVTDESSSESSSEIQNSATEISTDSEFAQDDPTPTREIPSIVLNDMYVNKAKRSGYNPRRKIQVTSRYLQSPLDGKTSKPNIDLKLTPLVPSALPVKKPAPLVLTHPQGYSLNRTQSTGGIAAKVSLELKKKYLLGEASPGNIQKSGSVSTLDTKFKSFHTNISDCQKLLKPSPEISASMQTFCKKLNELKSPVLSPQPSIIFTKEVEQKEDDHKENGDVLDENDIKIEPAVFENESEGRPRSPLHETSIIVPQIDWSKQHDSLTSDSLASSDNENEQKSERFENIPKVEIHAINDDEEIKDEFVPDSLLCVNDEIKTDIESPSIEPLKSISSEKKILNQPKVLPNLESVFPEIHNALHIKHKIHKEREREVPETIVISSGLSSPESLAEQATTALTETELSDWARDEAMLDDFEDGEFEIHIKYPDKDQKPAKMADLLEFDDSTSSYLAKSRKDNVIETVNSVLNVNLDNIEFMDTGTETSSDDGVINSQDGYILLKDEDDFAEDSLNPNINDIVETTNINVLQYPKEETIKKETDLKQADLEPSKHVQDHEEDVSTLIIESGTTTEENTLTDSTVKHVSDITVDKTLVNEINTVDKNENCDLKNDVVEESKQKKMIDNNLEFQEHCQRLQNKIEFSNVKDSIDIRKSRKKSKQDVLQKPDLITEETANIVTPPKNISLNLTPHTPHTPDILYNKDVIKKERDINQKLIQEMVMNKMKAENKSLEKRKRNKAGMSPKSPFELTKSATVINVPLSHPSNVAQTTNKRHSGTYTTPDVLLSSKCPLQTSEDVNVKFIRSETTTTPVRTTPSYSNNHVSPNLDDTPKAPPRYHRSAEEMNRKLEKLKQTVRLRHKENEQLVHIKEKTDSASQKRDQTFRRCVSGNYEAACPTFSSLEQSSLSSNRAKSIPNFSQQITTVQTISLDPERIKVYKSDPNILETNEGQNKKKSKDRERRKSITKLITDFFTKKSPSSSGSKGLFSKLSPKSKEMSKSCSILDFKKAHLAREAAQRKCLSESFINRNASPPPVPPLPVNYTRKTDESSDGEEKHGKHDSSCDTLDLTGISTGSMAGRRSTKSRRVSRQAQLKRHRMAQELQRKLEETEVKMKELEDRGVLVEKSLRGEASFDPSKDEADLLQEWFDLMRDRTELRRFERELTVRAQELELEDRHARLQHELRERIENDKPKTKEDVETEESIINEMIEIVEKRDSLISEIEEDRLRFSSDNINQSDIVDIDAKKLITSACFILVLSYLFWVVILFSVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL00</accession>
    <name>A0A6P7GL00_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114340074</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_028146602.1">
        <property type="nucleotide sequence ID" value="XM_028290801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL00"/>
    <dbReference type="FunCoup" id="A0A6P7GL00">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648018.1">
        <property type="protein sequence ID" value="XP_050503975.1"/>
        <property type="gene ID" value="LOC126882941"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GL00"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="16">
        <location>
            <begin position="127"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028146602.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47088" checksum="21F43010587FBCB0" modified="2020-12-02" version="1">MKCFLKYPKYCDFPIENLPYGVFTTPQEPSPRIGVAIADLILDLNEVAHLFIGPELRNHQNVFKEATLNSLMALSPQAWKEARETIQSLLSEDNTILQNDVDLRKRAFVSQSEATMHLPARIGDYTDFYSSIHHATNVGIMFRSRENALMPNWKHLPVGYHGRASSVVVSGTSIHRPYGQTLVMDGTDPVFGPCKLMDFELEMAFFVGGSNKLGEPIKMENAEDHIFGFVIMNDWSARDIQKWEYVPLGPFLAKNLGTTISPWVVTTLALEPFKTDNFPQDPKPLPYLRHTDKFNFDINLQVDLTPKGGNVSTTVSRSNYKYLYWTPKQQLVHHTITGCNVNPGDLMGSGTISGETSDSFGSMLEISWKGTKPVSLLDGSQRKFLQDGDTVTMKAVCEGHNFNIGFGTCVGTLLPAKNLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GL80</accession>
    <name>A0A6P7GL80_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19">Forkhead box protein O-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC114338148</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18 19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with melt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144524.1">
        <property type="nucleotide sequence ID" value="XM_028288723.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028144525.1">
        <property type="nucleotide sequence ID" value="XM_028288724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GL80"/>
    <dbReference type="EnsemblMetazoa" id="XM_050652073.1">
        <property type="protein sequence ID" value="XP_050508030.1"/>
        <property type="gene ID" value="LOC126885495"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="15">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="13">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_028144524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028144525.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15725" checksum="A914987BB07D9CE3" modified="2020-12-02" version="1">MNGQYGNWVQKMDMSMMEPLPELDGFEPQTRARSNTWPLPRPDNYVDPADEATGNKCVVAGQQGQGPVPSSVTSAVPTKKNSSRRNAWGNLSYADLITQAIKTSPDQRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GMR2</accession>
    <name>A0A6P7GMR2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Proton-coupled folate transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC114338698</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9 10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028145089.1">
        <property type="nucleotide sequence ID" value="XM_028289288.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028145090.1">
        <property type="nucleotide sequence ID" value="XM_028289289.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504223.1">
        <property type="nucleotide sequence ID" value="XM_050648266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GMR2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648266.1">
        <property type="protein sequence ID" value="XP_050504223.1"/>
        <property type="gene ID" value="LOC114338698"/>
    </dbReference>
    <dbReference type="GeneID" id="114338698"/>
    <dbReference type="KEGG" id="dvv:114338698"/>
    <dbReference type="OrthoDB" id="430300at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF39">
        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="12"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028145089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028145090.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="52000" checksum="C11CBE623C10808D" modified="2020-12-02" version="1">MAFKTNLIELPLLLMFLALELLGPVGTNLTLYRTCYIILGHNQTECALLGNTESPALNDLQKKVQPTVNVISSVSDIVSQVVGLTICLFAGQWSDRFGRKPMLLASQIGHFFSMLIMVVLSAIPSINPWYFMLSTVPVMLTGGFATFLVTILSYFSDISTDETRGMRMAMLEGMLGAGQLFGSLCSSYIYYATNYPSMYGIAAGIMGLNIIYIYFFLSESLENIEHKKSWKDMLKPSDLKGMFHVLTKPREYFKRAIILLMTPIMVLYIFISQGDGGKTYVFLMGKFNWDLQHYTIFNSVTIIIFVIGTLGGTYVFKKLKVTESVVVLLGLLCTFSSDLVRGLATKYFHIYIAAAVRFISGIVSPQCRTLISKLVPVNEMAKVFALIMVIEFVISVGAAPFYTLIYNSTVKTDPGFYNFVSCGLLGIDMIIILVVMLLEYKTALIYAKVDTKEEHTTPETFSETNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GTP9</accession>
    <name>A0A6P7GTP9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114342150</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148733.1">
        <property type="nucleotide sequence ID" value="XM_028292932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GTP9"/>
    <dbReference type="FunCoup" id="A0A6P7GTP9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659988.1">
        <property type="protein sequence ID" value="XP_050515945.1"/>
        <property type="gene ID" value="LOC126890799"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GTP9"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028148733.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="48817" checksum="AC65607B445F12E1" modified="2020-12-02" version="1">MTTASSYVNIFKFRLSLKNYIKMKVAFCTDLDKSVVLANCEKRNWIQVGPDDEWNIYWAGTLTCRSLFSVDSGYRMNDNQIINHFPNHYEISRKDLLVKNIKRYRRDLEKDCNPLAERSESKYLYLDFIPVTFVLPADYNMFVEEYRKAPQSTWIMKPCGRSQGAGIFLINKLSKLKRWSRESKTPFQQQIGKESYVISKYIDNPLLIGGKKFDLRLYVLVTSFRPLKAYQFRLGFCRFCTVKYDSSVAELDNMYIHLTNVSVQKHGGEYNSLHGGKLSVQNLRLHLESTKGKKITEKLFDQISWLIIHSLKAIAPVIATDRHCFECYGYDIIIDNNLKPWLIEVNASPSLTSTTANDRILKHKLLDNIFNIVIPPSGMPDVRWNKIPSPQALGDFELLIDEDMVGQSEAGGDMNIKTNKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GX44</accession>
    <name>A0A6P7GX44_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114347841</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028154306.1">
        <property type="nucleotide sequence ID" value="XM_028298505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GX44"/>
    <dbReference type="FunCoup" id="A0A6P7GX44">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028298505.2">
        <property type="protein sequence ID" value="XP_028154306.1"/>
        <property type="gene ID" value="LOC114347841"/>
    </dbReference>
    <dbReference type="GeneID" id="114347841"/>
    <dbReference type="KEGG" id="dvv:114347841"/>
    <dbReference type="CTD" id="39484"/>
    <dbReference type="InParanoid" id="A0A6P7GX44"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028154306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028154306.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29364" checksum="8909883B13DEC0FF" modified="2020-12-02" version="1">MARGPKKHLKRLNAPKAWMLDKLGGVFAPRPSTGPHKLRESLPLVIFLRNRLKYALTNSEVTKIVMQRLIKVDGKVRTDSNYPAGFMDVITIEKTGEFFRLIYDVKGRFAIHRITAEEAKYKLCKVRRVQTGPKGIPFLVTHDGRTIRYPDPNIKVNDTIQLEIATSKILDYIKFESGNLCMITGGRNLGRVGTVINRERHPGSFDIVHVKDANGHVFATRLNNVFIIGKGAKAFVSLPRGKGVKLSIAEERDKRLAAKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GX77</accession>
    <name>A0A6P7GX77_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114343404</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028150023.1">
        <property type="nucleotide sequence ID" value="XM_028294222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GX77"/>
    <dbReference type="FunCoup" id="A0A6P7GX77">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661849.1">
        <property type="protein sequence ID" value="XP_050517806.1"/>
        <property type="gene ID" value="LOC126892337"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GX77"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028150023.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8870" checksum="58A095A0903AAD4A" modified="2020-12-02" version="1">MVDTARLTRYASPVNPAIFPHLTLVLLGIGIFFTAWFFVYEVTSTKKSRSLKKELLVALVASIFSGFGILFLLLSVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GZU9</accession>
    <name>A0A6P7GZU9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sorting nexin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114345074</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151697.1">
        <property type="nucleotide sequence ID" value="XM_028295896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GZU9"/>
    <dbReference type="FunCoup" id="A0A6P7GZU9">
        <property type="interactions" value="2289"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657782.1">
        <property type="protein sequence ID" value="XP_050513739.1"/>
        <property type="gene ID" value="LOC126889464"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GZU9"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07623">
        <property type="entry name" value="BAR_SNX1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000047">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000012">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="85"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028151697.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53677" checksum="F3F8AF15A0B37FD2" modified="2020-12-02" version="1">MAEPVEPPPLFENIDILAQSKDDDDLFVSAHQDSVQDELEPTVPPRLAVSDLKEELENIPINNHSILSPSMEQVSPQEEMEKEDEFLDISITEPQKIGDGMGAYMAYRVTTKTNMPMFKKKEFAVSRRFSDFLGLHDKLTEKYLKVGRIIPPAPEKSVIGMTKIKMSSQDGPTTNGNDFVERRRASLERYLKRTAQHPVLVLDPDFRDFLESDIELPKATSTSALSSAGVMRLFNKVGETVNKITYKMDETDPWFEEKLNHVEALEMQLRKLHASVEAMVSYRKELANLTNGVSRSAAMLSACEDHNSLSRALSQLADTEEKVEALHIEQANTDFFIFCELLKDYLGLLGAVRDAFHERTKLFQHWQHAQQMLAKKRENKAKVKIAGGNDKAEQTNAELVEWESKVERGQENFDRISQMIKKEMERFEKCRVQEFKTMFIKYLENHMEHQAQLVKYWEAFLPEAKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H8C0</accession>
    <name>A0A6P7H8C0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114345573</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_028152180.1">
        <property type="nucleotide sequence ID" value="XM_028296379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H8C0"/>
    <dbReference type="FunCoup" id="A0A6P7H8C0">
        <property type="interactions" value="2063"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028296379.2">
        <property type="protein sequence ID" value="XP_028152180.1"/>
        <property type="gene ID" value="LOC114345573"/>
    </dbReference>
    <dbReference type="GeneID" id="114345573"/>
    <dbReference type="KEGG" id="dvv:114345573"/>
    <dbReference type="CTD" id="40610"/>
    <dbReference type="InParanoid" id="A0A6P7H8C0"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028152180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028152180.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17223" checksum="82A6BD150E314089" modified="2020-12-02" version="1">MSTPARRRLMRDFKRLQEDPPTGVSGAPTDNNIMIWNAVIFGPHDTPFEDGTFKLTIEFTEEYPNKPPTVRFVSHMFHPNVYADGGICLDILQNRWSPTYDVSAILTSIQSLLSDPNPNSPANSMAAQLYKENRREYEKRVKACVEQSFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H8V8</accession>
    <name>A0A6P7H8V8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone RNA hairpin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114345771</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028152360.1">
        <property type="nucleotide sequence ID" value="XM_028296559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H8V8"/>
    <dbReference type="FunCoup" id="A0A6P7H8V8">
        <property type="interactions" value="1803"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648398.1">
        <property type="protein sequence ID" value="XP_050504355.1"/>
        <property type="gene ID" value="LOC126883144"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7H8V8"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000001">
        <property type="entry name" value="Histone RNA hairpin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028152360.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33925" checksum="976F77705F4AE271" modified="2020-12-02" version="1">MNDPRLKVKRELKEEGELDDSFIDSIISSEQSHIKNIKPDPDGPCDKIQTHSKGSTIDSGITIKQEKEDGLGKQKQEKEESKNEILNTPIKTEQFRDESNPSPFNKELFQNFTLHSPATKDWVELMEEEVRQNDRKRAVKRVFTEPIKEESSTSSSSSSSGEWKTGSGNSSNEELEVLPPAKKTRNELRTLNGNKHPRRPKEYETDPAVLARRQKQIDYGKNTLGYDEYLKQVPKDERQPEQPKTPNKYIKYSRRGWDGLIKQWRLLLHQYDPLEESDKAKDEPKTEVEESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9D0</accession>
    <name>A0ABM5I9D0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028127917.2">
        <property type="nucleotide sequence ID" value="XM_028272116.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272116.2">
        <property type="protein sequence ID" value="XP_028127917.2"/>
        <property type="gene ID" value="LOC114324311"/>
    </dbReference>
    <dbReference type="GeneID" id="114324311"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027905">
        <property type="entry name" value="CFAP95"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15139">
        <property type="entry name" value="CFAP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028127917.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="25654" checksum="D1B9987E95F90021" modified="2025-10-08" version="1">MFVLETIKTKPMDHRPKVTLYSKKQYSPGIKVTDWYNIYNAQPVDRNPYCPKHNLFTSHYVNLGNDYSTKWVTTTRNMLDQVYTRRRELEINPNKQLVNVYTTIDIPEQKPKPLNYEDCYVSTMHSSYTTPYEYPIKRLTMTDPPFLQNRKFSHSPKCKFLDDTFLKETKDLQLHKINRHVSYNCNTNMYTDGSSGYVRENKCYDLNFYENDKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5I9N8</accession>
    <name>A0ABM5I9N8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028128092.2">
        <property type="nucleotide sequence ID" value="XM_028272291.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128093.2">
        <property type="nucleotide sequence ID" value="XM_028272292.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028128094.2">
        <property type="nucleotide sequence ID" value="XM_028272293.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272291.2">
        <property type="protein sequence ID" value="XP_028128092.2"/>
        <property type="gene ID" value="LOC114324438"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272292.2">
        <property type="protein sequence ID" value="XP_028128093.2"/>
        <property type="gene ID" value="LOC114324438"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272293.2">
        <property type="protein sequence ID" value="XP_028128094.2"/>
        <property type="gene ID" value="LOC114324438"/>
    </dbReference>
    <dbReference type="GeneID" id="114324438"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="172"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128093.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="383" mass="43389" checksum="A3FF757AC637B651" modified="2025-10-08" version="1">MNIDIILTDPDGTYKPDDIIRGTVTLDLTSTQNIQNILCKFVGNEETSWATSESLYDERTNTMRSGIVHYKGEHNIISCEEQLAKDLILPIGRHDFPFAITVPKRIPSSYSSNNGWIKFGLAVTIQNDLVLYEKEIPIHVKAPINFNDIRGEIQLEPIVYQNEEIIWHCCYAGDPVTMDLILEREAYTVNEPITFKLEVNNKSDREISEIDVTLTLVVETTAAAPRRSRKYYEKLLTGAKARGLAHGQQELYSFRFQVPDVIDIPNFIGSTLFRQKCVLKAECKIQDSDTKLDVQTELKLGHIPVERSRRITHPHGPVRRVHSSGAINRPLGFNFFNTSDNASAPPADYQPTAPRTTDDIDNLPPSYEEAIRATFDARKTKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IB93</accession>
    <name>A0ABM5IB93_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028129072.2">
        <property type="nucleotide sequence ID" value="XM_028273271.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028129075.2">
        <property type="nucleotide sequence ID" value="XM_028273274.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273271.2">
        <property type="protein sequence ID" value="XP_028129072.2"/>
        <property type="gene ID" value="LOC114325263"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273274.2">
        <property type="protein sequence ID" value="XP_028129075.2"/>
        <property type="gene ID" value="LOC114325263"/>
    </dbReference>
    <dbReference type="GeneID" id="114325263"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1061" mass="121557" checksum="6F34D7EF8DBDEAF5" modified="2025-10-08" version="1">MVDVDKLTDAELRTKLLEFGFPVMPITGTTRKVMAKKLKMLLENKNKIGGGEGRRSLGRYSSEDESDNDAKVTKKKDNRRATMAAPLMQPPASSPKLRKSTRYDDEPEAPPSPVKRDIRTVTTTSSTRSQKIIKNAQDEFDTGSDSESDLTNYNSKGFISDQRGSPLKSTLSSTSKYSPSKSVESSYFSTKNISNYASASPSRVSTYNSPSLASEYATDRLNQIRSRLSLNTPSYDKPSYTTSEDREETPFLSNFTKKLSTLSSPQKNDYDYKNDIIKEHDANGSASVRTQLSSYRATRGRDTSYDYRLNKYNILQNNFMSFGVLALVALFFIVLAIMYMGMKPDTSVISSDFTLPPCVEDDPNSKKWVNCISKRDANNAMHLLEVLKPELQKRAETHFCSDSKVFPQMTEFEIEDFCVSNFEVKNTTQVYNDLRNLMLLCSQNAHWGINVAQTDDKVRSSRAVTEEDLVKDMEEVFLYSDVKLTSLVMLKPDLPFKCSFVNSLSSWKSLIYSSFSLIFQSSLFLIIVFGLLYTLNVAYKYYKHHAQQEKDELGFMVERIIDILQSKASEDSNMDDFVVINHARDMILPVGDRKKKASTWAKAVKFINENESRVRTEIQEVKGEPFEVWRWIGSANLSMSGDEPSFTYRQGRRIVDPEFFIREVLKFPHKFMRFCSNSDITFKSEVRDGFLSIFVLECRKCKAQHSVCNEESESDLLDVNLAFVAGVISLGLNFYGLNEICSSLRMPLVPLESYNEYLDEIYKIYNETTYKDDSLSKIGDDSVTKEQDIETLGLEHPTLRTSTPKIPNTNNLNQRKLSPRSNIPKPQLRSDTYEEKKTRFLKALEKTPQEIDELQKMTLDQKDSSVWVKERRQRLTASNFGRICKLRDSTDRKNVVEELLNSKFFGNKYTKYGNDNEPNALKDFEKLLGVKVVNCGVFVSKDYPFLAASPDGLIGKDGLVEIKCPYKSQNVTPEEGIRSKLIQCATLENNVFKLKREDKYYYQVQGQLFVTGRQYCYFVVWTPLGLLYERIIKDEQFWNNELQKLEEFYFDHLLPALLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ICV0</accession>
    <name>A0ABM5ICV0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit Tim16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028130037.2">
        <property type="nucleotide sequence ID" value="XM_028274236.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274236.2">
        <property type="protein sequence ID" value="XP_028130037.2"/>
        <property type="gene ID" value="LOC114326033"/>
    </dbReference>
    <dbReference type="GeneID" id="114326033"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028130037.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14463" checksum="1F9F6748B764442E" modified="2025-10-08" version="1">MARYIAQLIIAGSQVIGRAFARAIKQEIEASQQAAQRLGNAKTRTERVANQKLGLSLDEAKQILNIRNLTKEEIEEKYQHLFKANEKTSLYLQSKIVRAKERLDHELTSSEEPREKKRPEETDSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIC9</accession>
    <name>A0ABM5IIC9_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028133499.2">
        <property type="nucleotide sequence ID" value="XM_028277698.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277698.2">
        <property type="protein sequence ID" value="XP_028133499.2"/>
        <property type="gene ID" value="LOC114328743"/>
    </dbReference>
    <dbReference type="GeneID" id="114328743"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF66">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE TAILOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="8">
        <location>
            <begin position="580"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="7">
        <location>
            <begin position="796"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133499.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="897" mass="103238" checksum="649D666D24888CB5" modified="2025-10-08" version="1">MDDKDLLNSENISEDTHVLNHLENGAYLSSNNIPVSEVVEKVSEFSNFLNSKGRLSLLHANPAESQELVPLMLSVKKNIKSALSEIGQSQIKKIRSYVCPKCDETIKVPPYVDNWTYFQDHEHFEELYVSFLEGSLTISTAMEIEPRASTSGEYLEESDLLDNEHTDSGIDYEEGIRETLSEDEEEPLGSNTFRFNFKPQYDPVVESTLYPDSFKSLKKFDSCQYLCIQKVNSYRAFCLLCCCDLVTKNAAKRISVKHCINHVLGQRHTKACSDELCAGSLEKYHQLFYNLELPYQAHQVYFTPKTLGSLECRLCCTTVQHKNLIEHVQGRMHKNIILDLFKSQKLSEYYLMEHHLSMYGINTDKLKPKDSPAKDNPEKKPRERREKSKSTSGNEAAAEVEHMFVRTFPFPPTGTPADFIPNRYAEHIKYFKDKDTHFGCEACNVYIKMDRADVKNHILSERHQKSSQIKTPKYKYLCEPCSVHLRDENDWDKHFKKPEQRHSKQPQSRLDKFAEYECTTCKYVIFGDEISTTRHKVKAGGKREKPSEPKLTDEIKNLFKSTEDIEEECERLMANNALMSLQKTKDCTKRIEEVLLTVLAECKAYPFGSRESGLGNDKSDLDLYIDVGGMYYGAKNQDALFQAHIVKQVESILSKHRTEFSRIVTVPGARTPIVKVHHISTGIDCDLSFRHGLSVENTKFLKKCLEIQPITQPFILILKKWLQFTQMSEHVTTYALAMLVIFYLQVNGYLLSVEKLNALNPLPAPVISGWKTIKYTASLELLKSKVTQYSGSVVPLLKGFFKYYASFNYFDDAVCPLLGHTIQRKLFQDPRRLPPEMKSYVKQLREKEPEQFRYLSPFCIQDPFDLSHNLTKACQGVSLTVFKKYCTLTHEYLSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IIV9</accession>
    <name>A0ABM5IIV9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028133834.2">
        <property type="nucleotide sequence ID" value="XM_028278033.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278033.2">
        <property type="protein sequence ID" value="XP_028133834.2"/>
        <property type="gene ID" value="LOC114329019"/>
    </dbReference>
    <dbReference type="GeneID" id="114329019"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133834.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="218" mass="25741" checksum="37486836DB6C5698" modified="2025-10-08" version="1">MILEDQLRLKLLEVTNAEDYRLMLRDEEDALYPPWFFTWVDKKLTAFAWPQTRGNLEYLWQIGMRHIITLCPEKIPNIDESKFSWTYIPIEECTAPSIDQIFKFIRTVQMCRKHELPVGIHDRMGLGRSGVMVSIYLMYFHRMTADQAIKNLRYHRPGSLDSAVQEECVLNYRPNAKEANDNRLKRMMKNSNHFLSILQGEDRQGIWGLPKAEYAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IU59</accession>
    <name>A0ABM5IU59_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028142022.2">
        <property type="nucleotide sequence ID" value="XM_028286221.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028286221.2">
        <property type="protein sequence ID" value="XP_028142022.2"/>
        <property type="gene ID" value="LOC114335932"/>
    </dbReference>
    <dbReference type="GeneID" id="114335932"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046805554" evidence="2">
        <location>
            <begin position="19"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142022.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="520" mass="55156" checksum="50999DDDD34FD857" modified="2025-10-08" version="1">MKNLIFFLYAILVPSLNAIPVDVIQRNIPVEVRYDQILPGIVSREQVLMHGRRNLDAKVQLSSDELPQVLKHLPIPLESDLVPEIVSEEKVQVASEVENNAVKSLIQPEDQESVEVLPEKPIDLPIEVPETPFVKSLLAPEPLSDSNTVLQKAAPKPAQTLDSVLQETQNIIRVGLKNLRDSFKPNKGELGPTAEQWATLEKQVDEYFSEEKHKLAIRQSQPVEGGSTAAPVAQQPQNNWVQNIVNGINGIASNFVQSIQSIGSATSGGAQPPNGQADEGAAGAPPSNGFQGFVQFFNNGISNIVSTITGTNNNQPTTSNNNLSDPGSGATQAPGNVIGGFFGTIVSNVQNAFGIQPPPQGAQGDTGSQQQNGPVQVIQSVGNAISNFFGGNRPPSNSQGDEGASAQPGNSNIIQNIQNAIQNSPLNPFRPQNGQTQVNANPVQQAVQSIGTQVQQLIPTGGSGASPQPQPANPSGAKNPVSAQAGSEDLKPVEAVPVLEIEEPIKENEIVKKQLPLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IVQ9</accession>
    <name>A0ABM5IVQ9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028144102.2">
        <property type="nucleotide sequence ID" value="XM_028288301.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028288301.2">
        <property type="protein sequence ID" value="XP_028144102.2"/>
        <property type="gene ID" value="LOC114337767"/>
    </dbReference>
    <dbReference type="GeneID" id="114337767"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046530263" description="TM2 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028144102.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="177" mass="20074" checksum="B94FA265A672960F" modified="2025-10-08" version="1">MMLINVFIIPFLLLQILPINSEEQEPFDPRGPLVNCSFLSFEFIECQDPVDHKGNKTAKEELKYGCVKFGGMKYHDVERTKVVCTALPSIECHGNRTFFREGVPCIKYSNQYFTTTLLYSILLGFLGMDRFCLGQTGTAVGKLLTIGGLGVWWIVDIVLLVMNYLTPEDDSSWNPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IXV8</accession>
    <name>A0ABM5IXV8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028147935.2">
        <property type="nucleotide sequence ID" value="XM_028292134.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028292134.2">
        <property type="protein sequence ID" value="XP_028147935.2"/>
        <property type="gene ID" value="LOC114341347"/>
    </dbReference>
    <dbReference type="GeneID" id="114341347"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147935.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="154" mass="17741" checksum="3AC325717E967899" modified="2025-10-08" version="1">MDDLLQYVLELSRESALLPSVKGKSQNNSHQEALVIRENATLNLFNDSSTIDVHEEIIVESEDPTKPGSSQQKIEETPGKKRTILTPKGNRRNVGLKQSSLDYLQKKMTAGLKSGVGNWHSKRGRKRYKKKNLNWQNGKQRRGPKWRKKDWKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5J0Q1</accession>
    <name>A0ABM5J0Q1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028155747.2">
        <property type="nucleotide sequence ID" value="XM_028299946.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028299946.2">
        <property type="protein sequence ID" value="XP_028155747.2"/>
        <property type="gene ID" value="LOC114349539"/>
    </dbReference>
    <dbReference type="GeneID" id="114349539"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="104"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="406"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="758"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028155747.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="143953" checksum="56104312A5E7E1EE" modified="2025-10-08" version="1">MDHCQRERRKPNPRETANIFSFLTFAYVGGLFRKAGKADLTEEDIFEVITNCKSKTCGDYLEQEWMNEKKLEKHPSLVRVLWNCYGLKYLLLGFIDFVVCTSRSIMTPYFISHLVGYFSPGQTTYTREDGYFYGYSYLIYICVDTVYNHQYLLWVQTLGMEVRTAFASLLYRKALRLSPVAVAETSLGNIVTLITRDVQSFVAVIFTINDLWIAITQTVIICYMLYSKIGIASFVGIGILLSSIPLQVLITTFIAKCRLAGCKKTDERLQLTQEILTTIKIIKMYTWENFFSRKVSQARKVEMKKLTLAFYLKRVLILNGILFTNLGFFMVILATIWTGVSTDTTVIFFVLSNFRYLRGWLGGAVPFGLGLGSEFVASFKRISKALNAEELNKDQHSEQLIEKPRVELDEISVQLKGEPVLDNVSFTITSGLTMITGAVGSGKSSILKVILKDLPLTKGFVETQGRISYASQDPWLFPSSIRQNILFGEPYNAQRYQEVVKACALLFDFNLFENGDETILTDNGQNLSKGQQARINLARAVYRNSDIYLLDDSLTALDASVQDHIFHECIQKFLKGKICVLVCQTASQIKEADNVIIMENGRIKDMGKPTARIIQQSYMIADQDDSIEKEVIHDSNQPTIEESSEKTGLIEAEQSTARTKIYKEQKKEGSVDWYVYKKFMIYGGGVFLILLNIVMRGFTQFTTTSADRLLTKWVDKKQAVMTIQNSIANISTEQFSYMNITLETAQAEEHTTFRFYYLCLLASSSLELLTTWLLLSFCKTASINIHKALVYQINNSVMRFFDTHLIGNILTRFSQDMMNIDESIAYNLDQFCRMLFSMGGILTLTIFINPAFAVCVIVVTIMLFWVRSCYLPAGRSMKRLEASSRSPMLGHLNATLEGLTTVRASNVQSILIEEYDRHLDLYTSANFTWYMSSRAFGFFVDMLSNFFLIFIIMDYLFFKRDITAGDIGLSLTQISQLSIVLTWGIRVFTELENHMTSLERVIEYTDIKTEKKDGTTVQNWPSTGSISYQNVYLAYGDSDSFVLKNLNFEIKPGEKIGVVGRTGAGKSSILATLFRLYEVKGKIIIDGVDIKTLALDYLRKNIVVIPQDPILFSGTIRSNLDPLNEFEDKDLWHTLERVGINTSIVSLEQPINSSIMNFSSGQKQLLCLARAILRKNKLVVMDEATANMDHETDRMLHKIISDNFADCTVLTIAHRLHSVLVCDKVMLLDRGEMKEFDQPQELLKNRNGMFYKMVKQAGLLNYLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JGX9</accession>
    <name>A0ABM5JGX9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497195.1">
        <property type="nucleotide sequence ID" value="XM_050641238.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050497196.1">
        <property type="nucleotide sequence ID" value="XM_050641239.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641238.1">
        <property type="protein sequence ID" value="XP_050497195.1"/>
        <property type="gene ID" value="LOC126878488"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641239.1">
        <property type="protein sequence ID" value="XP_050497196.1"/>
        <property type="gene ID" value="LOC126878488"/>
    </dbReference>
    <dbReference type="GeneID" id="126878488"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08688">
        <property type="entry name" value="C2_KIAA0528-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037785">
        <property type="entry name" value="C2_C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038983">
        <property type="entry name" value="C2CD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057815">
        <property type="entry name" value="C2CD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056430">
        <property type="entry name" value="C2CD5_YbjQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056431">
        <property type="entry name" value="C2CD5_YbjQ-rel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37412:SF2">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23025">
        <property type="entry name" value="YbjQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23028">
        <property type="entry name" value="YbjQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23128">
        <property type="entry name" value="YbjQ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1602" mass="179548" checksum="AA3039352298BBB6" modified="2025-10-08" version="1">MPGKVKVKISSGKNLPVMDRSSDTTDAYVEIKLGSTTFKTDVCRKSLHPQWNTDWYRFEVEDSELQDEPLQIRLMDHDTYSANDAIGKVYLNLNPLLLPVDGQIMKYGFNGDSSIHHEISGWLPVYDTMHGIRGEVNITVKVELFSDFNRFRQSSCGVQFFYSPTVPQGYQAKLIHGFVEELVVYDDPEYQWIDKIRTPRASNEARQTLFFKLSGELQRKIGVKTLNLGGNAVIGYKQSYDLEGESGIVARGIGTAITLTVSNTSSNGPILPGENKDEHVKDYLEFVGDGKSFRLSSTPNVLSFMLPAFSKVSKIANVTFPKYKRKSRKIDSFVDSGSIRASHSIEDISHSPMERLLQQENERGKTYGLPQKLKNFKYSQKSLSKKMTAFKSKLSGSVGEKIDEEPVVQKKYLHKRSDSDSSFMAEVLARSAIQVHNSLTCILEVKNQSTEEGKSNQKSDKFNKMMSDSNTVSDESASEGQGSYSDSTTSDEEDDSLNIKNSQKDLDTISTIVKDVEMLQIKQKPSLLKQRSLPAFEISRLDSVSSLSTAYTYRPVDTNWDLSDNENNEKECRNNSDSVIEETTSETVFPKEDCEKTTITDKNALFEIGEKETSVTDKDSDEQVVEVKNVKPAFKGIVPEAIKSVKIEERSLVRTAIQTLLLDKAQILGTYTPPITPSEVKDTEFPKAFLSGDTTQKSRMPKSASSVSFIEYVKKREHVLGVPFTDITATKVFKRRQSQPCLLKSDALIPKTNTKIYSDNQLNKPLVKTLLHESLNKKKLPAKLNISSDQKSTLSLNSGEIRRVSSDSSDKKSKPNLLFRIFSKKISRPAPTCSNTPTDSDLTSINISSNDSNTDIKNQSDICTSTKHACITPNRHNISPQADQIGSTYQQNLEQRKSDQSPSRLNILAQRRSSDSDLSTTPKGFNRKRNSLTSSEKSGGHPSSSFIRNNMVLRSQIHQENFDMLEYPFLTILKFPADFISHIGGAVSARSVKRLETIRNIEEPESRDTWWSEIRMEIRSHARSLNCNAVLGYYESSSICEDICILSAYGTAVVLNFHKSDDADEYASLLKQNITATPNETCSLSYEKNQYDRDKQKMENTHSNNKHSDSPDFSTNTGNSVCTITHLPYASSDIPVKATLGKCMICRKGKVPEVLIATIEPLDGIPSTGRGCFIESYVCRPLKDLKGEWSAKEISDGLPFLEYELHRLLVNKLKIKGMNAIFGLKFRITVGEKLIIATATGTAIFLTSLPSPTVPKLVSDENVDDPKIITLQKQLKETVKKNKEIYKIEDGIEGSRAWSDDDSDEEPTSLDLSSGSKDCCVLEVDDPKDEEVLCSLMKERPPDGFHVVNTETIPGLDDLEIVKNLQMFIQCRRFKFQSNLNIDEYFSKLLQSVYFKLRRMVPCALCNIQFRCDIPEPDEVQLLVFGMALGLGKKSKGFKSVIPRKEEEDMIFKLEEDSITENNTVQGNKINKVNKLRSSSKYKSSLKQRHTPQKEIHGVDITPLSYVPGASVDKYLGNINFFFIRETTSIREEGGLSGFLHSFVTEVLAIVRAHVTALGGNALVAFFLTELFLNHNFHKNQGQCLINVGGDVVSVTSYKEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JHM3</accession>
    <name>A0ABM5JHM3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050497436.1">
        <property type="nucleotide sequence ID" value="XM_050641479.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050641479.1">
        <property type="protein sequence ID" value="XP_050497436.1"/>
        <property type="gene ID" value="LOC126878647"/>
    </dbReference>
    <dbReference type="GeneID" id="126878647"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="283" mass="32538" checksum="22555C280AD0B60D" modified="2025-10-08" version="1">MGDIGDLSDDIIQNLIKARDILFQNYTPREANIWLKHIKRHLTLFNKAIRYGDLDVPKLRQLQTNVGHLKTIKVEIQNFSHHVGAGINKRSKVKWEEVTSSFASRVRTGIIINLAHKDVMQFFGDCFKLFKIRIKNILKKFNVIKCNTAFCGKFIRKANQGENSEFKYFNTKNEIIDAGTDLMLWFHSNVIDKIMAKLSEFEEKGSGWAFEKIISLEVNINKNEIGNGASSFIKLPDQIRNKNACINVKNNDEACFFWSIVSLLYPSKANSDRTSHIHITQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JJA1</accession>
    <name>A0ABM5JJA1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498013.1">
        <property type="nucleotide sequence ID" value="XM_050642056.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642056.1">
        <property type="protein sequence ID" value="XP_050498013.1"/>
        <property type="gene ID" value="LOC126879113"/>
    </dbReference>
    <dbReference type="GeneID" id="126879113"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="201" mass="23046" checksum="1B45AEA690F43911" modified="2025-10-08" version="1">MKNVLVILRRILHKSLTSSLSEWCCKHNITHVAINDLLNILKPYHPELPRDARTLLHTLRKTILQPINSGHYIYFGLRNCLQKLLSQYSGEECLDTVEILINIDGLPLSKSSSSQVYPILCSIYPKQGPVDIVGIYHGYEKPKDSNLFLEKFVEDAIEIINNEAAIKSEKCSDKKVAEQEIGRWLRRAGDRLKTFKEKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JK86</accession>
    <name>A0ABM5JK86_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498351.1">
        <property type="nucleotide sequence ID" value="XM_050642394.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642394.1">
        <property type="protein sequence ID" value="XP_050498351.1"/>
        <property type="gene ID" value="LOC114324660"/>
    </dbReference>
    <dbReference type="GeneID" id="114324660"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="173" mass="19848" checksum="B1A741C3AB83870C" modified="2025-10-08" version="1">MKYITTMSTTTTIEIGDEGVSKITEDLGNYLAKTDFFGETFLWNILDNVSLVTWWKGFCGHSCLSKVAVRILTMPCTSAATERSFSSQSSIHTKRRNRLTTQRAANLNYIQYNSKLLKRSRQHHIQSQYPIEETVQNNVSIEGRNLQKEIEVIENHISEEEELDEVILNLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLS9</accession>
    <name>A0ABM5JLS9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050498898.1">
        <property type="nucleotide sequence ID" value="XM_050642941.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642941.1">
        <property type="protein sequence ID" value="XP_050498898.1"/>
        <property type="gene ID" value="LOC114335850"/>
    </dbReference>
    <dbReference type="GeneID" id="114335850"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21150">
        <property type="entry name" value="PUA_NSun6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF34">
        <property type="entry name" value="TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="447" mass="49021" checksum="1DC2E062DD2A277D" modified="2025-10-08" version="1">MVYPNSPFKTTFNNKLITNLFLDDSVTKTKTSVSNEELLKIQQWLCSAPKITSIRVNTIKTNTAKVLKVLKTYFAENCNDTPNVYIHPSFTNVIIIDSLNCPAEFKKFDKEIIVDTDCAAAILRGAHIFAPGVLGMVSGSQINENVSIYADVAKKCKKGLQKIYEDDFKIFIGNGIVKMQRHQLFATDNIAPSGIAVEVTETISGCVPISESLLPVGDILLQNIPSIVCVHNLNPKPGDVVLDMCASPGNKTTHIAELMQNKGILIAIDKTPKKVAQLQKRCEDFGAKVYSFQADSTAIISDTLSSKNVIDGPPFAPQSFDKILLDAPCSVLGKRPQLANRSSENEIKSFVPLQRKLFENAAKLLKPGGIMVYSTCTITLSENEGIVAWALKSFNFLELVQPDLTLGEPGWLGTSLSDEARSFVQRFGPNSEVDSVGFFFAVFKQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JLV5</accession>
    <name>A0ABM5JLV5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050498922.1">
        <property type="nucleotide sequence ID" value="XM_050642965.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050642965.1">
        <property type="protein sequence ID" value="XP_050498922.1"/>
        <property type="gene ID" value="LOC114329370"/>
    </dbReference>
    <dbReference type="GeneID" id="114329370"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="35"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050498922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="345" mass="37976" checksum="921C2A19BCBAC485" modified="2025-10-08" version="1">MNKIFTRLISRSLSKTLKSDKHASTYKAAVITEIGKPLEIQEKKVIKLKPSEVRVQVVYCSVNSVDVYKFKHDGGQLPFIPGYELSGEILEKGSEIKDEVLRIGERVVGLNLVKFGGFAEQCILDINDVWRIPGDVERKDAAVIAYGHSTALYAFSKLTSIKEKEKVIISAGPAGMGLAAVDIAANVYKAQVVGLVDTEERGELVRERGAFETLHFSDKLVKQCMKITDNKGASIVYDATGTEMMESIGKCVKVGGKLFHAAPYFYKTIPSPVPHSFATILSLKELSNQNPSLYRSIVSDTLEMANQGLINAHISAKFSLEEVNDAIKFIDEKKCTGKVLINIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JMQ8</accession>
    <name>A0ABM5JMQ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prisilkin-39-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050499224.1">
        <property type="nucleotide sequence ID" value="XM_050643267.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050643267.1">
        <property type="protein sequence ID" value="XP_050499224.1"/>
        <property type="gene ID" value="LOC126879920"/>
    </dbReference>
    <dbReference type="GeneID" id="126879920"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046532238" description="Prisilkin-39-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050499224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18248" checksum="3912B1BD3A5D5BA2" modified="2025-10-08" version="1">MQIVVICLCLFVAAAHAGGYGLLNTNGYGSYGSGYGGYNGYNSLGYGGYNSLYGKDYGGYSGVGGYSGVGSYSGYGGYGGSGSYGGYGGYGGYGGYSGYKPGYYRPGYGGSYGSYNPGYGGNYYPGNSGWNNYNDYDYNGYRGYGSSYGGYGGTNFLGGGYRPYSGSGWSSSKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JQQ7</accession>
    <name>A0ABM5JQQ7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050500274.1">
        <property type="nucleotide sequence ID" value="XM_050644317.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644317.1">
        <property type="protein sequence ID" value="XP_050500274.1"/>
        <property type="gene ID" value="LOC126880452"/>
    </dbReference>
    <dbReference type="GeneID" id="126880452"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017213">
        <property type="entry name" value="Peptidase_S54_rhomboid_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF8">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037470">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="361" mass="41640" checksum="975C2C70C03CB617" modified="2025-10-08" version="1">MSSSSDESKSTLEEKEKADQHKYYKSVFRKFDKDKSGGVELSELAETLELDDEIPRHISERIFKAADRNRNNVLDFEEFRNMVRNASYKEVFSRYINLYIQYVLPKRKHHLVYSEPDALYEEKYTCWPPPIALIIISAIELTLFIINEEPAESNNYGENYPIGKMLIYDPYKREEAWRFLTYMFVHIGYTHLIVNLVVQLFLGFPLEMVHKWRVLTVYFAGVLAGSLGTSVTDPRTYLAGASAGVYALITGHIGTIYMNWNEMDFPLIQLGVFLLITCIDIGTSLYNKFYLELNDNIGYVAHASGAVAGLLVGIWNLKNFVPSRRETYIWWGAVTVYIIFMGILICINIFWTEHFLTGANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRJ8</accession>
    <name>A0ABM5JRJ8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="10"/>
    <dbReference type="RefSeq" id="XP_050500563.1">
        <property type="nucleotide sequence ID" value="XM_050644606.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644606.1">
        <property type="protein sequence ID" value="XP_050500563.1"/>
        <property type="gene ID" value="LOC114332601"/>
    </dbReference>
    <dbReference type="GeneID" id="114332601"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07853">
        <property type="entry name" value="STKc_NLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="59"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="457" mass="51428" checksum="5216163A2BC0C012" modified="2025-10-08" version="1">MAVAVPNCHSRVSMSVSMSLMQGTAGPTTGAGQQGGLHGAQPYYHPQHAAAPAHTQEQVQPDRPIGYGAFGVVWAVTDPRDGRRVALKKLPKVFQSVISSKRVFRELKMLCFFKHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSHQPLSSDHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDTSKNMTQEVVTQYYRAPEILMGTTHYSAAVDVWSVGCIFGELLGRRILFQAQNTVQQLELITELLGTPSMEDMKHACEAAKSHMLRRVPKPPSLSALYTLSSQATHEVVHLLCQMLVFNPDKRITVVEALAHPYLDEGRLRYHSCMCKCCYTTASGMRQYTSEFETTAPQPFDDHWEKKLNTVQQVKEEMHKFIAEQLNTSRVPLCINPQSAAFKSFASSTVAHPSELPPSPHQWESPRVVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JRL7</accession>
    <name>A0ABM5JRL7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050500583.1">
        <property type="nucleotide sequence ID" value="XM_050644626.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050644626.1">
        <property type="protein sequence ID" value="XP_050500583.1"/>
        <property type="gene ID" value="LOC126880620"/>
    </dbReference>
    <dbReference type="GeneID" id="126880620"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="145" mass="16182" checksum="39FD3C361FD858DB" modified="2025-10-08" version="1">MLLEPIANTITSVEGDTPTISKCLHLFKKMVNTSLENVTKSPLLSKEEADTRAIFENRKKFAIYSVHFVANLLDPKYRGCELSSDEMTDATEVIYKVSQKMPDVDEAAVLADVVNFIAKEGLFKKAFLWNEDTIAAILASQSILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JT01</accession>
    <name>A0ABM5JT01_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein takeout-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050501068.1">
        <property type="nucleotide sequence ID" value="XM_050645111.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645111.1">
        <property type="protein sequence ID" value="XP_050501068.1"/>
        <property type="gene ID" value="LOC114330343"/>
    </dbReference>
    <dbReference type="GeneID" id="114330343"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047475714" description="Protein takeout-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27512" checksum="C421E9163362E2C3" modified="2025-10-08" version="1">MTKFFVILVLTLSVSLCYSTNISELFKICHQSDKDLDTCLKGAIEVAIKAIGSKGIPDLDVPPVEPIAVKEITFGSGTDAVQLDQMYHDVKLIGFTDNLKITKAHYHTGKKSLAFTTFNPVLKQQGKYDLKGKILVIPVYGKGDSIVTLKDVTMNHFMTFGEEKKQGKTYLKVINYVAELSIKGANFDFKNLFDGNKLLSDNILKVVNENWSVIIGELRPGIVKSYAQIFSAIAQSVVSKVPVDDIFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVF2</accession>
    <name>A0ABM5JVF2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Farnesyl pyrophosphate synthase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501923.1">
        <property type="nucleotide sequence ID" value="XM_050645966.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645966.1">
        <property type="protein sequence ID" value="XP_050501923.1"/>
        <property type="gene ID" value="LOC126881605"/>
    </dbReference>
    <dbReference type="GeneID" id="126881605"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45959" checksum="A2945EF417F455FB" modified="2025-10-08" version="1">MLRNILKGFINVPKSEFNLARFSSFRTLNQKENQQQKENVRPNYENRQRNLDLAFETNAILSTYPEIHEELINEQLIYHQNYPDLKLRFSKLLDHHLKLDPKYLARAIFMVHAYRLLEKPSVLNQSNLKNAYVLGWCHKMHDASLLLDDDIADAADTRYNKPTWHTLPDVGVNQAILDAAFLETGANILILNHLSSHPQCINILKSILKSFSITNVAQIFELQQFKMEEVEKYQNFIKFYHYNLPLIKSALYLANIDDESIHAIAEEICLEIAVFHKIHDDVTCVFSPFSDIQKSCTDISEGRPTWLAVEAYKRGNQEQRKILENHYGVNNKASVAEVYKVFTQLKLKEAYDELKEDFYEDMHFKIHNKLPKCIPPKLFIDLLDFVVNDRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JVF7</accession>
    <name>A0ABM5JVF7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Farnesyl pyrophosphate synthase-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050501926.1">
        <property type="nucleotide sequence ID" value="XM_050645969.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645969.1">
        <property type="protein sequence ID" value="XP_050501926.1"/>
        <property type="gene ID" value="LOC126881607"/>
    </dbReference>
    <dbReference type="GeneID" id="126881607"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="45090" checksum="3348562E722DBC07" modified="2025-10-08" version="1">MLKTILKNMCLKRTKLARFSSQNTNNINNVSENSAFQTQCKPVDLSFETKKMYAAFPSICEEIVDEQLIYHQAYPELRERYFNLLEYTVNIDQPRNIGKGIFFVHSYRMLEKPSILTDDNLKKACVLGWCQRMVDVSVIIDDDVFDVSDWRYNKPTWHSLKCVGQNKAILDAAFVESSVWYLLIKQFKSHKYFPDILKQVLMSYAVTQTSQCLELTKYDVKDLDKYTYSVRGYGFAAPLLRTALYLANIEDKDAHEFSEKITNDMSHFIKCEDDFNGVFNPMSDIQKSCTDISEGRPSWLAIQAYQKSSPAQKTILEQHYGKANKESVSKCYELFKELKLDQVFTKYREVFYNDIYLNIHKNMPKKLPKELYLNFLNFCMTGALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JWZ4</accession>
    <name>A0ABM5JWZ4_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Potassium voltage-gated channel subfamily H member 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050502464.1">
        <property type="nucleotide sequence ID" value="XM_050646507.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646507.1">
        <property type="protein sequence ID" value="XP_050502464.1"/>
        <property type="gene ID" value="LOC126881865"/>
    </dbReference>
    <dbReference type="GeneID" id="126881865"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="816"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="961"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1281"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="146734" checksum="40B68530176A3585" modified="2025-10-08" version="1">MRFLWCSGFIYRVLLFLLTRTLLVRCLGNSVAYFLIMNSIAHGEIVKIIAKLEKKSVGNSPDRSFLVANSREGQCHIIYCSDGFCRLTGYSRAEVMQRPASCEFLCGPLTSQQAVANLREALQDGVEKHAEILYYRKDGTKFLCSEVIAPIRSEVDDISLIIINFEDLTTVPASSLENSPIGKNRLSKFGRARASFRQSLRIGSSIRGRGLRLAGYLTPPSDVTAAEEEEDRLEQCPLTSSAPVPILEQTWVSKPEAAAVPLQTTIPSSAQIKDYTALTISHSAPASHQASFERGESIERTRPLHSTNNSNRQHHVIQNRVSHATSLDAIARRQCFKTGYPTVSLSNKPQLSKQFPNVSSESDLQRYRTAHGSDRKSPSLSNPTESLKQKVCPQFSFQDNGSAKYFQSGIHTPKMGEKVAQKMTAARVELPLAPKSPLSSLVLSLGADVLPEYKLQNPRIHNYTILHYSPFKAVWDWIILILVIYTAIFTPYVAAFLLGEPDFNNRKNKKYSEDPIVIIDLIVDVTFIIDILINFRTTYVTGNDEVVSDPGKIAFHYLKGWFLIDLVAAVPFDLLFFGTDTDELGLDKDETTTLIGLLKTARLLRLVRVARKIDRYSEYGAAVLLLLMATFALIAHWMACIWYAIGNAERPMLPTKIGWLDILANDTQQYYLPNNTGGPSIRSRYVTALYFTFTSLTSVGFGNVAPNTDAEKIFTICVMLAGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSVLKGFPECLQADICLHLNRNLLQNCSVFDGASPGCLRALSLKFKTTHAPPGDTLVHRGDVLTSLYFISRGSIEILRDDVVMAILGKYDIFGENPCLHPTLGKSACNVRALTYCDLHKIHRDDLLDVLELYPEFFTHFLNNLEVTFNLRDDEQAGVVPRRSFYPKDKENRYFRGVPSARSNGVSSRGNSVNGRQESQYSDESESGHGILEFSTDKAGQDVTPLNLDFGEEKRRSSTLNSITGMLSQLKRSIPDLRLHKTHQPLIAQSTPPSSHRIRTIRRQSSIGAYHHQDATTIASTQQQSAPQQPQLISGPLSSSTSYYTNSPSPPHVTDTGGTHVQEILVPLEPSSTSIHLQQHSTIETLTHSDNLVISRSILEHINSKLDHLTKRVNSLETTLASDVKTILSLLQAQQQPSSSEDSTVKQEMPEYENIAIDPSRTRYTFQRSVSEPKPISKNHHSQVLHRFASFNKAFDFDKGPELPWAECSITIEKDKEDKPAPIAKLESLDELDLESPLGSPKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JXX3</accession>
    <name>A0ABM5JXX3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">N-sulphoglucosamine sulphohydrolase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050502787.1">
        <property type="nucleotide sequence ID" value="XM_050646830.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050646830.1">
        <property type="protein sequence ID" value="XP_050502787.1"/>
        <property type="gene ID" value="LOC114332127"/>
    </dbReference>
    <dbReference type="GeneID" id="114332127"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="SGSH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="SGSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046339115" description="N-sulphoglucosamine sulphohydrolase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="N-sulphoglucosamine sulphohydrolase C-terminal" evidence="8">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58648" checksum="729D9DBF91BC1515" modified="2025-10-08" version="1">MYFWIILGCCLIQIDCTIPPKKLNALVILADDGGFEMGVYRNKICQTPNLDKLARQSLIFNKAFTSVSSCSPSRAALLTGTPSHQNGMYGLHQGVHNFNSLSNVNSISNILKQNGIRTGIIGKKHVGPEEVYPFDFSETEENNSILQVGRNITHIKLLARQFLNTSDPFFLYIGFHDPHRCGHTNPEYGEFCQKFGNGEPGMGVIPDWQPIIYQPEQLQLPYFIPNTLEARIDVAHQYTTISRLDQGVGLIIDELKKSGHYDNTLIIYSSDNGIPFPNGRTNLYDSGVAEPLLISSPLHKERRNHVTNSLASLLDVVPTLLDWYGIKDQNHNDIEENTVGTKFDYLTGKTLLPLLVEEPADKSKEIIFGSHNLHEITMFYPMRMARTQRYKLIHNLNYYAPFPIDQDLYLSPTFQDILNNTKSHKNPMWYKTLQEYYKRPEWELYDLKYDSAEVNNIVKKNSSQSIFQDLKKRLNLWQQQTKDPWICSPHAVLEDVGSFRNNPQCLDLDNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYH4</accession>
    <name>A0ABM5JYH4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050502985.1">
        <property type="nucleotide sequence ID" value="XM_050647028.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647028.1">
        <property type="protein sequence ID" value="XP_050502985.1"/>
        <property type="gene ID" value="LOC126882221"/>
    </dbReference>
    <dbReference type="GeneID" id="126882221"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050502985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="204" mass="24403" checksum="9F9D2D5138035FC3" modified="2025-10-08" version="1">MPRRKKGGDLASSAAKRRKQKEHRRNETEEEREARLQNQRTRMRTLRSTKNEERKENESIEESRILKDNLTKEAFHYEPTKKYYNHKHVVIGKMDNICQFCHAKKFSKETAGLCCMNGKIRLPPLEAPPQEFLHYMTGETQESKHFLQNIRSYNSCFQMTSFGVTSTNTNRNKFEYVFSIQGQIYHKIDQKMKQQHILLKYFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5JYZ5</accession>
    <name>A0ABM5JYZ5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503159.1">
        <property type="nucleotide sequence ID" value="XM_050647202.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647202.1">
        <property type="protein sequence ID" value="XP_050503159.1"/>
        <property type="gene ID" value="LOC126882324"/>
    </dbReference>
    <dbReference type="GeneID" id="126882324"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="124" mass="13492" checksum="94BCE29752ADD26C" modified="2025-10-08" version="1">MVKTSDMQSRLRSFVRPEAKEAVKNIVIKIIFIKKRIQGKLDIFSGQRTNERTKVFTNGYRPNYGTIMHYNQGTNDAQSQEAASGRGPPSPGELPGRGPADMPPGQNKQSEATNKGTAGGTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K001</accession>
    <name>A0ABM5K001_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050503515.1">
        <property type="nucleotide sequence ID" value="XM_050647558.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647558.1">
        <property type="protein sequence ID" value="XP_050503515.1"/>
        <property type="gene ID" value="LOC126882585"/>
    </dbReference>
    <dbReference type="GeneID" id="126882585"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33223:SF6">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="355" mass="41315" checksum="A6D5E87CDEC48BD0" modified="2025-10-08" version="1">MALPAVPQLKKEYLEMIPDFHGDVALLPRFIEICDKLVTKFYNVADPTDFQNEYLTSSILAKIKGEAAINISSCSIKTWENLKDALLNTYADKRDVYTLSIQITHLKQGNESPFEFFQKIQHLLNLQISLLQTRSNRNEQEILGSYFRNLALRVLLRGLKEPLGTFMRTKNPNDMNTALNVLTNDFQIYMGQNNSPKNQNPSSSNNFSNKNKSNSSNYVPPNNFNFQNNNYQRNNNYSQFPKNQYQNTQTRNFNNNQNPSNTSRTSNVFRPNQNQNLPNPTPMTISTNNTFRPNQNYQNRYKPRSQNQNYFARQPQNIIQEELHNIDEINNSDDKNVYQEDNDHFLEEIASDQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K1Z4</accession>
    <name>A0ABM5K1Z4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504211.1">
        <property type="nucleotide sequence ID" value="XM_050648254.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648254.1">
        <property type="protein sequence ID" value="XP_050504211.1"/>
        <property type="gene ID" value="LOC114337611"/>
    </dbReference>
    <dbReference type="GeneID" id="114337611"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="421" mass="48672" checksum="8DB5614CF844840A" modified="2025-10-08" version="1">MAATTFWYKRWREYKTAIHPAVEDSRHRLVQKLTLITWSVVVPIICGAQSPNSITEECKETLYTSKPTVYEKYLDMPKIKWRCQNSCGPSIGEVFLRYFGLTSLHFNDEDIQMALLPLMYKTSAYRLRLRIVDIVNKIIKDRNLTNGKLYSEAYVENRRQIPGRLATIYREMYYLISRSLEHDMPVALSIDNGFNCMVVQGFQYGGSFDTVNYTYVDPRTGNSKTESVEKLMGQTAKTIGDIYLMVYNPPLTDDETDFTACSELLNISNSIITMEPFAHLNHSKPNGICPPGLNYHHVITQGEDFFVLNHTDFNPDEIKVGLSLKTALGIEKIYFEVSDTEFKKYLRTLFKTVRQTTGTGLFGSIQKQDHDVMVDYMFEHYAYFHFAIRRLAKDKRLNLLEVATNRNRVFDPAKIKAIYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K308</accession>
    <name>A0ABM5K308_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504573.1">
        <property type="nucleotide sequence ID" value="XM_050648616.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504574.1">
        <property type="nucleotide sequence ID" value="XM_050648617.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648616.1">
        <property type="protein sequence ID" value="XP_050504573.1"/>
        <property type="gene ID" value="LOC126883279"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648617.1">
        <property type="protein sequence ID" value="XP_050504574.1"/>
        <property type="gene ID" value="LOC126883279"/>
    </dbReference>
    <dbReference type="GeneID" id="126883279"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF72">
        <property type="entry name" value="FI21449P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="173"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="595" mass="69336" checksum="900F3410C2FEF554" modified="2025-10-08" version="1">MDLPKTFEVGNYTECFLSGNQYCKFGAILKYPKDNLTLMNYVKSIYEDKTQRDPYLIHREICIPNTLSTCKESVYQFAINSINEKLKYNISTSEITQSTCTNGTYEINTYDKIIVLLIILYTSLVFISTYFDKYKRNRFRGYPDKFLLHFSLYRSWKNRTDISKNENYQKLLSMQGLRVYMMLIVFLLHLTFIYFNIPVKNPNYHRDLLYTGEAQYWSKYLLAWGTFIVLYFFVVSSWLATVQLYKTFENSGKITLRNVVVIIVNRYFRFISAAIFISIFISNWKYVVSTPFNFDVMRYTDNSCQQDLLLNIFMMANFKYWKNICYPVTWSLSADFQMYIINVIVIYIIFKYKLNEFRVYFSMLVGFCFINGFMIYWYNAGVIFNFDARETKLFILDDSVDFAINYLSTFSTASSSCIGIILGVIYVNIKSKEFSNGNTLYSIVWFLLFLGLPIFAVVLSTREGTGFVTAIYGALVKPVYCLGLGIGVLGMALNLGGHMKKIYENKYVVFLSNFTFSGYICHWALLHFLISIHEPPTLSNGYIVTAYVILSAASIIVAIFFTIFVEEPLLSLQKAILPQIKEQENIKNEMTKKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K353</accession>
    <name>A0ABM5K353_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xaa-Pro aminopeptidase ApepP-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050504618.1">
        <property type="nucleotide sequence ID" value="XM_050648661.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648661.1">
        <property type="protein sequence ID" value="XP_050504618.1"/>
        <property type="gene ID" value="LOC126883301"/>
    </dbReference>
    <dbReference type="GeneID" id="126883301"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047355137" description="Xaa-Pro aminopeptidase ApepP-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="387"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="6">
        <location>
            <begin position="610"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="81130" checksum="F27B508AF4816171" modified="2025-10-08" version="1">MQVWIAAVLLSYFTANALYDATFSQLEEDRRNGELRKACAKHGHAVQPARRLNSTERLIKLREAMVSEVKLETSAIQAYFITSSDEHQSTEVADYDKLWSYISGFTGSYTNIIVTANKAALWTDGRFHLQADEQIDCNWLLFREGHRDIPTMAEWIMKEFPHGSRLGLNPKLVSHHMWNQLEHELKGSRIQLVALNVSLVDIIWPKNERPEKINKEAFFLEEEYTGKNYPTKVNETRKELLKHRADAMIVTALDEIAWLLNIRGRDVPNSPYIRSYVILDMERVILYINISQVPKAVQEHLHYDPTFIGRDTVILKEYDDIWSDLGTLSQRYHKVLIPSHCVYSAGASHAIYEHIFENRRMLKQSPIIYLKAVKNEVEIKWMHYTSIRDAAAVCDCFAYIKKKMGRHEKIMESDLVQYLNEYRYEQNHSLGNSFRTRVAFASNAAFPSYETTDNTNTQIFNNSTVVLDSGGQYYGGTTEVTRTLHFGEPTDQMQDAYTRVLIGLMQLSTLTFPSNMKMAVADAMARASLWEAGLDYLHETGHGIGSFLGVHESPIKVHFNSEVSAQQVFKPGYFLSNAPGYYKEGVFGVRLGNVLQVVEKPWLRHSTQSYYGFRTITYVPFEPNLIKRHLLSIHQIKWLNQYNEQVRHLVGEELKKQNRMDGFYWMMEKTQYIPENHSTYLHSTPYLILLNIVFVIKYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K5J7</accession>
    <name>A0ABM5K5J7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050505465.1">
        <property type="nucleotide sequence ID" value="XM_050649508.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649508.1">
        <property type="protein sequence ID" value="XP_050505465.1"/>
        <property type="gene ID" value="LOC126883833"/>
    </dbReference>
    <dbReference type="GeneID" id="126883833"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050505465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="418" mass="48308" checksum="38F6611C57674375" modified="2025-10-08" version="1">MPKRHYIRRQVHQQEPHIFDLYQKPRFDDTIRKEEFRTYTPYIKSFNNSDVVEFIINQSDAFFAIHDTLLEIKGSIKKAGNGTVSLAPNAGSFLFDTCTYIQSSHDMEIVRDPGVVSTIRSLLCYTPEDSKFLSTAGWNYPNYPHLSGDAFSLLIPIKHIFNIFNDYTKLTYGRQVFRFVRARNDKDCIVVQEPTGSTTVTTVSLTIVSMELKVKHVFPNDDVKIELMTPIKNNSPITIPFRKWELNELPSLTAGSRREIWSVKTTSAVERPRYVIVAFQTSKRDDIHADPTLFDHIRMSSVRVVINGDYWPNERMQLDFTKNDYAIAHYNYTEFFPSYARSLTKHPILDYSAFKRYALFVFDCSKQDDTSFRSGTVDVKLEIEADEGFPAGTRAYCLIVHDSLLEYFPLTEVVKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K802</accession>
    <name>A0ABM5K802_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506317.1">
        <property type="nucleotide sequence ID" value="XM_050650360.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650360.1">
        <property type="protein sequence ID" value="XP_050506317.1"/>
        <property type="gene ID" value="LOC114336116"/>
    </dbReference>
    <dbReference type="GeneID" id="114336116"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1506"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1804"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1845" mass="208355" checksum="4FFF4F38752B76E9" modified="2025-10-08" version="1">MFAKRNLVDIKKSTSKLQDPKKDVATRIKHLKIILENVDTSDAKGFFEANFSHIYNILYESFVQTETNLRQRELSFHLVHKAHKEELECTLWILEQVLCLLPELIHRRWQLHSLSRLLAKLLHPGNSIKLRRQGIRYFLIWYQALNENAPEYVHNMFSALVPGFGSQNVFQSQHSGSVFHDTSAQHPVTATELLPILPPSNGEKSPENASKFYLEALLEYMVHTVVKLEWQDKNAHHHRCFSFLLEKFKLYYIPKMFPNFCKDTSLYKPNLDLPILRRPESENEFVQCRVSFILWTINYMHQTRKSQDKEGSVGPPSIQNMQSPSQHSHTSHDDDSQHDSSHPSLDSTISIQTNRTTSDEELGPQIVREVLYSTRDNINFLHELYRQAFLLNFTQVVAIRKIIGLYKDLIQGNVIEIPPYALEMPEDVPRNGNEDISVLERPTRLRNDSYLGAIHKENLLVRAGTQNIYQLFTTHAANVFLIEINSHAPRMLEEQTDACKRVLNIYRYMVMNTRMDSSTWEQLLTVLLQITSLVLGETPPKKKTVTLGGKLAPAIFQTLIVTWIKANLNVMISRELWDRFLQVLTTLTVWEELIKEWAKTMETLTRVLARHVYNLDLTNLPLDRLNDNRSKRSRRTTQRQEQSTPCSTGEPVHPVVSRQDSALPDGQLLSKRTRSTLSRSYSDNDLTLKRRSSQIKQRNLNRRRSKSLEFLAPQDTESTDRTRSPSPAPSSGMESNSIKDSPIQLDMLSADHQTLEFCGEHRGVICGGSIRGWLPDVAVIIWKRMLGALGDINKISDPKLHAQVFEYLVKLTDTLIKLSRNQGISFDNMSTPHPPELIPPLTLILPWCFGALVLPSNYEAGKLNALRLICTITVNCDSKHRTYLPQVYRFLHTALTGSSKLVINTCLKYLGPRFFSLQLPGASLLLLDFIHACNIILNNTEKLESSPRTEAMSFLANLLSHTENLNAISVLQPDSEMHIMTCPDIKEHIVSILLRAGRREPKGKARCIALSALGIFVYKELKNQTFHSKITDAINVLLLALKFNNKIIAQLASNILFLLCDHAPLLWSQYPRLSNAVISTLCSALFLHTPLGSTAGESDKALGTALLFCLGEWCMKLGPQRLLEISEYGETRGTCLLLQVFTVLHKIMLGKASLEHPGGLSQPSINDDFDPNILADDFEISEKISSSKNNQCQDAIKLCARTILSHLVSHLGHFPMAIGATRLSSLVAEHDDVPNLSSDDLSTSIFSASNIQLFILSKNIIASLVELPALELPEGGITAGLSTADKQVRVILRDLSGKSSWDASILYKNPEHIKQRIDLDFQKSQTDNVDSGIQMESLMVSSPLHNLPQRAIRHRPPSVLPDVSNAAPDLDQLDDLLQYLGYTSPECLENFNQKLNEPAAPPMSTDIENEAIASVISQRNLELEDSRFSQQIDSMLGQPVERPNSRSETSYPSFSSVAYQQNIATVTEQNAFQHCRLFFSQLGLAGWERRQQLHLLNKTERLLRELRNLDNQSCRETHKFAIIYVAPGQEDKNSVLSNQGGSIAYEQFLASLAWEVELEGHTGFLGGLQRQGTTGLTAPYIATSFLEAIFHVATRMPGDSPEAVLNKIRHLGNDEVHIVWSEHNRDYRRDIIPTEFCDILITIYPLGGNLNRVTINLKSDVPHFGVLFNEAIVETSVLAGLVRATAICASRAKRITYEFYQQYYEERAKSLETVVTKHKKGTTYEEFISKVYSPVLTPNLLYPNSLSSNNGDVGSNSMLAAALLDSHGHIPKSSQRADQKFRASANEVTRSGWFQNLDNQIVESSISPRPMKRISTNLKPSKKSVKRETSVESPPESPLQITRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5K827</accession>
    <name>A0ABM5K827_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050506342.1">
        <property type="nucleotide sequence ID" value="XM_050650385.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050650385.1">
        <property type="protein sequence ID" value="XP_050506342.1"/>
        <property type="gene ID" value="LOC126884456"/>
    </dbReference>
    <dbReference type="GeneID" id="126884456"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050506342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="333" mass="38682" checksum="A84FDC0FA847D069" modified="2025-10-08" version="1">MLEIKYILVAMDYFTKWTEAYALPNQEAATVAEVLVKEFFSRFGVPLEIHSDQGRNFESALFQNVCKLIGANKTRTTPLHPQSDGMVERMNRKMGKHLSKVVSEHQRDWDQHIHLFLMAYRSAVNETTGHTPTCLMLGREVRLPCDLEFGCRPSEEYVAGEEYVDRLKLRMKNIHELARQHIQIASDRMKDQYDSRCKNETFEVGDLVWLYNPQRRRGLCPKLQRQWEGPYEVKKKINDVIYRIKKLPNGKPKVIHINRLAPYAGSNETEEARVLQQEMKDAPQPSFKEFMSNYAERKSARFGVTTEVQQDLFGVPENVSLAHCVAQDLEMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KB43</accession>
    <name>A0ABM5KB43_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507404.1">
        <property type="nucleotide sequence ID" value="XM_050651447.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651447.1">
        <property type="protein sequence ID" value="XP_050507404.1"/>
        <property type="gene ID" value="LOC126885030"/>
    </dbReference>
    <dbReference type="GeneID" id="126885030"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="360" mass="41351" checksum="508EAEE7FC140523" modified="2025-10-08" version="1">MKSIPIEQHLSVDKQIIRYKGRSGLKQYNPKKPKKWGYKLFCLAGASGIVYDFEVYCGAHKQPDDLPDISASINVVIRLAERIPKNQNFLLFYDNWFCSPELQIKLSENGIQSLGTVRTNRVPKNKLPADKVLMKQGRGSCVEKVAVHNSTTLRVVKWYDNKAVTLLSTFASASPETTVQRYDRKKKESVTIKCPSIIILYNKFMGGVDLIDSLLALYRTKIRSRKYYLRIFFHLMDMSVIIAWLMYRRASDDCGIPKRQLSLYDFKADVAQSLCWASKLAKRGRPSGSTPSLDKKKIKTCVSANADCIADRMDHWPHYEKKTGRCKNKKCQKITKVKCTKCNCFLCFVPDRNCFLDFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KB68</accession>
    <name>A0ABM5KB68_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein ALP1-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050507429.1">
        <property type="nucleotide sequence ID" value="XM_050651472.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651472.1">
        <property type="protein sequence ID" value="XP_050507429.1"/>
        <property type="gene ID" value="LOC126885043"/>
    </dbReference>
    <dbReference type="GeneID" id="126885043"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="9">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="178"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="46581" checksum="5CDFD204D5203F08" modified="2025-10-08" version="1">MLFSSLVENMTSNESMLLLALLLRKKKRVRRTRKIHIHTMLASREEKGMYYTLFPELCAEEVNFFRYFRMSKSSFLELFNYIKEDIRGIDTKTKKCIPPEEKLVVTLSYLATGNSMTNLQYQFRISQPSISVIVRQVCDAIWKKVRPISFPDFNETFWLTTAKEFYERTNFPHCLGAIDGKQVRVIKPEASGSLYYNYKNYFSISLLAICDASYKFTFIDVGAYGKSSDSTVFKESTFYKKLEQNLLNIPAPQLSFHGFSEPMPFVFVGDEGFGLSTKILRPYGGKCLTIKKRVFNYRLSRARRYIECSFGILANKWRIFHRPLNVDITLCESIIKVCCVLHNFVRDRDGFHTEDTLKIDGLFDSTLVNEPSQKNATVLRDKFAEYFLSEAGAVPWQMDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KCK2</accession>
    <name>A0ABM5KCK2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050507905.1">
        <property type="nucleotide sequence ID" value="XM_050651948.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050651948.1">
        <property type="protein sequence ID" value="XP_050507905.1"/>
        <property type="gene ID" value="LOC126885385"/>
    </dbReference>
    <dbReference type="GeneID" id="126885385"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050507905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="565" mass="65400" checksum="B23D291039543F98" modified="2025-10-08" version="1">MFGHIITGNLVNINDSLVALETKFGWTVMGTQKSNNKINTFVSTYFTDSLSTLWSLDVLGIKDPAETKCREELDIRTLEKFKESTVVNSENRYEICLPWAEGYPAITSNFNLAEKRLFSTTKRLISLNKLTEYDNIFQDWENTGIIEEVEEEPLEKNTHYLAHHAVVKESSLTTKIRPVFDASAKDGNGNSLNDLLEKGPNLIELIIPLILKFRLHKIGVTSDIAKAFLQISISEKDRDFLRFLWWKNYEKREIKIFRHCRVVFGLKPSPFLLAATVNLHLEKEKTYTETANQLLNAFYVDNCVFSVRNETELKKFIDESTEILKNAKFDIRGWTFNENNDTYVSSVNEKLENKVISILGIQWNYQTDTLACDIKNLDSVDEIPRTKRGILSATQRVFDPIGFTAPFTLIPKILLQETWSLKLTWDQKLPDDIKKRFEIWLKSVKCLNFCNIHRYLAYPEEENLIINKTLHVFVDASKYSYAACVFIRLEFQNSISIKLLLAKSRLSPVKTITFPRLELMAAVIGVRLLETVKEVTDFTELKTYYWSDSMVVLTWIKTKGLWKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KDF0</accession>
    <name>A0ABM5KDF0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050508210.1">
        <property type="nucleotide sequence ID" value="XM_050652253.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652253.1">
        <property type="protein sequence ID" value="XP_050508210.1"/>
        <property type="gene ID" value="LOC126885624"/>
    </dbReference>
    <dbReference type="GeneID" id="126885624"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="64218" checksum="6DE20A2BE0AFC16D" modified="2025-10-08" version="1">MNDHIVPVTELCFDGNMGDNWSFFEQKFNIFLEASKLNEETDSLQGSVLLNRVGDRALRIYNNFEWSSDEKKTSCKAILKKFKEYFTPSKNVTYERYLFFTRDKIGLETYDSYVTELRQLASTCEFDTLTDSLIRDRLILGISDVSLKDRLLREQGLTLSRGLEICRAAEVAARQLSVISGANSSQSLEVLEIQKQKKHQSNRNQQPKSAPQYTADPGQSYRNHPQTSGNQKISNNFIKNCYKCGSNHSLNKCPAYGLRCKICNKFNHFAKVCNANSYRNRVHNVNVHQSDTDSDSDFSPDQFFLNNINEKSSEKWYEDCFINNKIIVSFRLDSGADCCVLPYTYFKKLNIQTSELTSSTNKITDYNGKIINTVGSVYLKVRQCKNKENIAKLKFYIVKTHNDAILGLDACIMLNLIQKNNINVINDNLHNDIESISQIIHEYDDAFRGVGCLKGKHTIKIDEKVAPRVHPPRKVPFAMHDKLMEKLKELERLEIIRKVTEPTDWRMLNYYLRKGDVMMTSFRWLAFARNCLFNKVKKREEEGAPLSDVNLNHVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KF50</accession>
    <name>A0ABM5KF50_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050508788.1">
        <property type="nucleotide sequence ID" value="XM_050652831.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050652831.1">
        <property type="protein sequence ID" value="XP_050508788.1"/>
        <property type="gene ID" value="LOC126885995"/>
    </dbReference>
    <dbReference type="GeneID" id="126885995"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="487" mass="55150" checksum="732309A86ACE8C89" modified="2025-10-08" version="1">MPRNYKRVTEKASWREEELQGALRAIQNGMSLRKAAIKFSIPKSTLHERLKNGTAPSGPSLGRKPVFSVEAENALAVQIKKLAKVFYGITPQEVRRCAFGFAQSNNIRVPFNQERKMAGKDWERGFISRHNITLRKPEATSINRITAFSRNEVTIFFNNLSRLMEKYAFSPNKIYNCDETGVTTVQRPPKIYAEKGQKRVGFVTSWERGKTTTAMCAVNATGTYIPPMFIFARQRMASHLQRNGPPGALYTCSKNGWITEDIFLTWLQHFQAFVKASKEDPVLLIMDNHSTHCTLQAYNFCRDNGTAVLTIPPHSSHRLQPLDVSFYFPLKTAFNSECSKYLTSHPGEKITPSEIAELFNLAFSRVATPEKAIKGFKETGIFPYNPDVFTDEDFAPAEILQSTVSDALQEPTQAEKLLKTNETTPEKNSSVNETELKNVSFAEIIPLPSCSHENVVKRQNKANKQHSIVFTSTPLKEELEKKRREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KFY3</accession>
    <name>A0ABM5KFY3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509100.1">
        <property type="nucleotide sequence ID" value="XM_050653143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653143.1">
        <property type="protein sequence ID" value="XP_050509100.1"/>
        <property type="gene ID" value="LOC126886273"/>
    </dbReference>
    <dbReference type="GeneID" id="126886273"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="146" mass="16854" checksum="900ABC8E82C1AA77" modified="2025-10-08" version="1">MPKLRKYDKNKLIEAVKDVQNGTESYRTAEKKYGIPKSTIEFKLKHPEHKDTLGPSPILTCEEENTLVRWIQETASKGFPKKANDLKSSVQKFLTENPRPNNFKHNRPGDGWLKDSDSDANNSNQDSEDEDIDELFTQYKEAQKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KGR9</accession>
    <name>A0ABM5KGR9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050509389.1">
        <property type="nucleotide sequence ID" value="XM_050653432.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050653432.1">
        <property type="protein sequence ID" value="XP_050509389.1"/>
        <property type="gene ID" value="LOC126886476"/>
    </dbReference>
    <dbReference type="GeneID" id="126886476"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050509389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="556" mass="66248" checksum="8325DB19A154A212" modified="2025-10-08" version="1">MIKYRSWRLFNNMDIKQETSEKTCKIEIDNETWVDPLDSFKFEIKEEPKRESSYETFDYLNEFPVSTKVEQDEHKCTLFEEKETSEESLCQNVFKMKSEISLVVRTGQKLYKCEICSKQFRQDGVLKRHLMIHIGKKPCKCEICSKQFSRDGDLKRHLRIHTGEKPYKCEICSKQFSRDGHLKSHLRIHTGEKPYKCEICFKQFSRDGVLKRHSRIHTGEKPYKCEICSKQFNVDVNLKRHLRIHTGEQPYNCEICSKEFSQDGDLKRHLRIHTGEKPYNCEICSKQFSRDGHLKSHLRIHTGEKPYKCEICFEQFSRDGILKRHLRIHTGEKPYKCEICSKQFNVDVNLKRHLRIHTGEQPYNCEICSKEFSHDRDLKRHLRIHTGEKPYRCEICSKQFSQDGDLKRHLRIHTGEKPYKCEICSKLFSRDGHLKSHLRIHTGEKPYKCEICFKQFSQDVNLKRHLRIHTGEKPYKCEICSKQFSRDGDLKSHSRIHTEEKPYKCEICSKQFSRYGVLKRHLRIHTGEKPYKCDICFMRFGKDGILKKHLTTHTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KKA0</accession>
    <name>A0ABM5KKA0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510631.1">
        <property type="nucleotide sequence ID" value="XM_050654674.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050654674.1">
        <property type="protein sequence ID" value="XP_050510631.1"/>
        <property type="gene ID" value="LOC126887256"/>
    </dbReference>
    <dbReference type="GeneID" id="126887256"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="304" mass="36325" checksum="D87AE6ED1F9F1A5D" modified="2025-10-08" version="1">MMIPKPQRIPFWKNNILVYQLPVWICIYTIIPVLSVIVFRYAHFRKNTDKKNFGSSVGNNIFFVLGLSLNVSANKIPKSWNLRVLLGFYLFFCLLELTYRQTKITSFSTISLHEKRVRNIEDLIDSDIPVKSFRSSAMVLPDNSPLLSKIEYLPDEPYENLTLRAAEERFATIWGEIGFVAHPFLYEVMDYFNLYMYQIGFYMPETHIFYEHFDLSMRKVIQRGFLEMLYGKYKHFFMLKYRHAYPSKDLSVKKDLKSCMFMFIVLFAGYCVSLLVFGIELLMAKRWNTLTKNRWFCKWFWKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KL85</accession>
    <name>A0ABM5KL85_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL24m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L24, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050510962.1">
        <property type="nucleotide sequence ID" value="XM_050655005.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655005.1">
        <property type="protein sequence ID" value="XP_050510962.1"/>
        <property type="gene ID" value="LOC126887462"/>
    </dbReference>
    <dbReference type="GeneID" id="126887462"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050510962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="252" mass="29781" checksum="CF97DB7C65535ABB" modified="2025-10-08" version="1">MRITDILFSRVGKWSKQFSNLPDRYIKRAMEQVYWRNPKGIQYKPHAVVQRKKYNFTVNRPWTLQFRQDNASGTMHKKVWVEPIKEWSHFRGDRVEILVGKDKGKQGIIKEIIQERNWVIVEGLNCELKQIGDDKEFQGVWVKSEKPLLVTSEIVLVDPSDLAPTTIEWRYTDEGERVRVSTRTGRIIPMPPSMEETYDYKTKATYKEQPKDTASDVASEITFKPELKTFEMDIMDKMGIKEDRIPPKSYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KMX6</accession>
    <name>A0ABM5KMX6_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050511523.1">
        <property type="nucleotide sequence ID" value="XM_050655566.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655566.1">
        <property type="protein sequence ID" value="XP_050511523.1"/>
        <property type="gene ID" value="LOC126887760"/>
    </dbReference>
    <dbReference type="GeneID" id="126887760"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="373" mass="44265" checksum="006C72B0489547EA" modified="2025-10-08" version="1">MHLTKKAIELKCHQLLTFNKQSRIFCFVLCKMSYNIDIRRGVYNMVGRMSKRDIVNIYRDQNISKSTIYRTIRECEEGIPCVNLRKSGRPRILNHIREARLIEARKNKIGVSQRKLARRFHVGKTTVYRTLSSNNIIYRKRRKAPKYTEDQLERIPRCCRALRRVHFVNKLIVMDDEKYFTLSNSEMKGNDGFYTNYYENVPDEIKFKSKKKFEDKILLWCAISEAGFISQPYIGVVRGEALNANIYIQRCLSKLLQFVNTHHANDQIVFWPDLASCHYARITRDWYETNNITFVPKADNPPNLPQARPVEEFWAILSRKVYNNGWEAQNQEQLRRRIYTKIREIDAEVVQRMMQRVRGIIRQIENNGPFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNX5</accession>
    <name>A0ABM5KNX5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511895.1">
        <property type="nucleotide sequence ID" value="XM_050655938.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050655938.1">
        <property type="protein sequence ID" value="XP_050511895.1"/>
        <property type="gene ID" value="LOC114327667"/>
    </dbReference>
    <dbReference type="GeneID" id="114327667"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045626582" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="63"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="317" mass="35267" checksum="D2F8E4A4E5A61F39" modified="2025-10-08" version="1">MSGRCFILFAYVLYVGIFKIVDTQDGQPIKSTVNNINFTRSPAIPDRKMCGFQEPHKMPQLRIVGGTETSLKEHPWMALLGYKTRYGEFKWKCGGTLISQRYVLTAAHCVTGQIVPVVGNLTYVKFGLHNRNKEASCDIHGNCNEKAVIRGIESVSFHKDYDTTVRISSGDIAVIRLNQTVEYSTYIRPICLAEPYEESKTNDRLTVVGWGQTETCNCSQVKLKADVPVLTNQYCNHKYYGLTRLDDSQICAGGEQGRDTCNADSGGPLLRLIENGTQWYQEGIISGGTSDCGQAGLPGIYTKVSSFLSWIHSHVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KNX6</accession>
    <name>A0ABM5KNX6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 97-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050511889.1">
        <property type="nucleotide sequence ID" value="XM_050655932.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="XP_050511889.1"/>
        <property type="gene ID" value="LOC126887971"/>
    </dbReference>
    <dbReference type="GeneID" id="126887971"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038791">
        <property type="entry name" value="Cfap97/Hemingway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23035">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050511889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21604" checksum="B9EC894B807E77FD" modified="2025-10-08" version="1">MARAPRDGIGILTKLNDCTTCESIQNIAPSPSPCELSRSENFNTSSQNIEIKDASDKNDSSIVSDSDSEEISYDDDFEPLEADDDDKGHGDSRSVRSISSQSQSSFCASTTLKLPNRTFPDSEIREIERQNDILMKKILSNNRRPNQYKPRSTDFRLPSSAAVNRKRQEAKIARENQILLRKIQTVKSSFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KRU0</accession>
    <name>A0ABM5KRU0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050512906.1">
        <property type="nucleotide sequence ID" value="XM_050656949.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050656949.1">
        <property type="protein sequence ID" value="XP_050512906.1"/>
        <property type="gene ID" value="LOC126888595"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050512906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="83872" checksum="59AE53C720704F8B" modified="2025-10-08" version="1">MRQVKTLSKQLKVEQKKGAGLKTRPETAKRRVHWEDSVSTFNSRIQTGVISNLKHKDPGSFLVDCKALFKRRIQNVLKNNAAVKVNIAFGGEFEIAQGEKMMNETKYFTTSNSAIYRDTNLDEWFEKKVVEPINRDLEEFQERDSGWALKAVVNLGVNINKFTPQLGSSYIDLPAQIKRQQACSNVKNDDEACFAWAVISALYPCRNNSALMSSYPHYSQVLKLKGIQWPMTAKQIPNFEKQNNISINVYILKKEKKNYTTLPTFLTKNKKDKHVNLLLIQNKYDEQGPLKYHYVWIKNLSRLLSKQLSNEDGTKYFCDGCLYYFRSQEKLNVHKTCCKGRSDVLCDRCLQPFLSSTQLEAHINDCERINETAIKMPEESQKMLKFKNFRNKLKAPFAVYADLESVLEHSAEKTTYQKHIPAAVGYYFKCSYDDFLSFYKSYRGKDCMKWFADELNQLAEDVSTVFMCPFDINMTFQQESDFQAATHCHICEQRFSPSDKKMRDHNHLIPENNYRFAAHEGCNINYKDAHTIPVIFHNLSGYDAHFIINDIATHIKGPVDLLPITKEKYISFTKHINDARIKFRFIDSFRFMASSLDKLSSYLTEYPNLRSQYVFLPEEQFNLLTVKSIMPYDYIDSFDRFIETCLPPIEFFYNKLEDKPCPRRHYHRALQVWSSFSCSSLGDYVDLYMKTDILLLADVFERFRFSCLETYNLDPAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KU40</accession>
    <name>A0ABM5KU40_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="RefSeq" id="XP_050513707.1">
        <property type="nucleotide sequence ID" value="XM_050657750.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657750.1">
        <property type="protein sequence ID" value="XP_050513707.1"/>
        <property type="gene ID" value="LOC126889442"/>
    </dbReference>
    <dbReference type="GeneID" id="126889442"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90234">
        <property type="entry name" value="Zinc finger domain of DNA polymerase-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="517"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="817"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1281"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="1485" mass="169996" checksum="55BABAED9F52B35C" modified="2025-10-08" version="1">MEDSPQEARSNRRSRDTSYKSKAFEKFKQLKKGLKNKYEVDEIDNVYEVVEEKQYVKEVLSRYDDDWIVDDDGGGYVEDGRDIFDDDLDMESIAQASAKSKGTKRKTKNVSENAGKGKIQQMLSSLPSKKKVETKIDDDEMLSEILGEIDSSPSTSGQKPKIKEYSALAKKLAAKDYMKNFSQPSKKRVIERKSLPNEEAGEVTHGSVLKEVQSNVGKSTKKPQRNVTEQTVINPFKKVKETPAVKQPQTEAAQEVIEETPLETFDDTLTEDFDDDPMFEELDKTPTPVASSQKVASQTIETDLTQDDFGDDFDVTQIEEFESQPSGDVEEASEKLSDELQAEFETEWGNFMNKTVDIDNTTEALLDKSDIPTIDDEGKKIFRFFWWDAYEDPLKQRGTVFLFGRTYCEKSKSFVSCCVAVRNIDRRLFVLPRPYELGPDGQPTDTPVTFKKMYEEFNDRVLKPIGVSTFRSRQTSKKYAFDPNIPQESEYMEVRYPANDPKIDADLIPKKTRTFSKIFGVNTSFLEIFFLERKIKGPCWLDISNPVPVTNPLSWCKFEVNCTKMVDLKVTVTEKPLPPPPLVVTAINIRTCINRKTCGHEIVMASCLTHKKYAVDMQPPDPPFQQHFCVIASPGDQTLPFDIHDALSKYKATKVQKMDSEKGLLNFFVNQFSSIDPDLIVGHDLQGYQINILAERLSKLNTNIFNKLGRLKRSEKKNLEKSLFAGRLVCDIKISAKELIKSRSYDLDALCQVVLKLNENQRIELEPDDVPKMFKTTSDILKLISFTMQDTMYILKIMYNLNVIPLALQITNIAGNVMSKTLMGGRSERNEFLLLHAFSEKGYILPDKEYKKRGDGKQSSKKKPTYAGGLVLDPKVGFYDNLILLMDFNSLYPSIIQEYNICFTTLPISDNDENLFLPDSNLPPGVLPTEIRKLVESRRQVKGMMKKPDISLDLRMQYDIRQMALKLTANSMYGCLGFSNSRFYAKNLAALVTQKGREILTNTRDMIEKMNFNVVYGDTDSIMINTNILEYDQVFKIGVKIKQEVNKLYKQVELDIDGVFKYLLLLKKKKYAAVTLNKDKNGKLVAVKEYKGLDIVRRDWSQISSEAGKYILNQILSDQSADERIEHIREYLRKIREHLTEGKVPTPLLIITKQLTKEPHMYPDKNSLPHVLVALRYNQKSGGHFRAGDTVPYIICEDGTTNSAVQRAYHVDELKSNSELKVDVMYYLGQQIHPVVSRICEPIEGIDSYEIAECLGLDTKNIKRPRQAVNELVGENISRPEVKFRNVDKFKFICYGCKQDNIVEGALVGNAPFLERCRNADCSLKPIDYLPSIQNQLTLSIQSYINKYYENILICEDPACTNETNRLPLKFARKYPICTLCQKGVMFRVYNEQQLYTQLSYFQHIFDLSKLSKKPLMEQEIESGYSSLQDVVEKYLNHSGYSIIDLTDLFSMLDPHKKRETTTIDVNRDVDEDVQYMDEDEEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KU43</accession>
    <name>A0ABM5KU43_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="RefSeq" id="XP_050513708.1">
        <property type="nucleotide sequence ID" value="XM_050657751.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050657751.1">
        <property type="protein sequence ID" value="XP_050513708.1"/>
        <property type="gene ID" value="LOC126889443"/>
    </dbReference>
    <dbReference type="GeneID" id="126889443"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF24">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="359"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050513708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="537" mass="61393" checksum="EAB77F36872D95A4" modified="2025-10-08" version="1">MPVADFFIDKNVFVTGGSGFLGKVLIEKLLRSCPGIGNIYVLLRPKRSKSIEERLEKVLESPIFNPLRHQNPDVFKKLIPIKGDVSELNLGINKEDRELLVNTVNIIYHSAASVRFDDFLKDAIILNVRGTREVAKLALDLKNISIFVHISTAYSNCDKLVVEEKLYPAHANWRDAITIAEECDPKTLQVFSQKYIFPLPNTYTFAKSLGEHVVNELCQGKIPVVITRPSVVMQTLSEPIQGYIENYNGPTGLMTALGIGVIRIIYGNRDAVVDYIPADYVIKGIILATESQRTKKTTSDNIEIYNMSYNPILRITLEEIMRFGDKLYKENPYSQMLRHPKVALTENFYKFYSEVIISHMLPSLLVDLILRLIGQIPRLVRIQRRIYIAAIVLLPFMTNTYSLKNDKFLNLQKNLKEEDSAFSYKYLPWTVEERDAYMRSGKLGMEAYLLKSKSVITGAKAKRQLMNTSHMRPFWVRQQSFYRITSVGRLGWGRRGSCDLHRLFQGIRQGKSQNLAQQTRNCWYSGNIIGMASQLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXM1</accession>
    <name>A0ABM5KXM1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein 7-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050514935.1">
        <property type="nucleotide sequence ID" value="XM_050658978.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658978.1">
        <property type="protein sequence ID" value="XP_050514935.1"/>
        <property type="gene ID" value="LOC126890130"/>
    </dbReference>
    <dbReference type="GeneID" id="126890130"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18511" checksum="32841F60F92890C3" modified="2025-10-08" version="1">MYLVDDGNHCILPKLSLSAVAQAGVLDYGHGHGQATSYASTSLGVSDNGHGYAAPALSHGYAAPLARGYSAHGESTHPDEHINTHPKYEFNYGVKDEHTGDHKSQQEIRDGDVVKGSYTVAEADGTLRTVHYTADDHNGFNAVVERSGHPVHPAPAHGKVLLAAPAAYGAPSYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KXN7</accession>
    <name>A0ABM5KXN7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_050514950.1">
        <property type="nucleotide sequence ID" value="XM_050658993.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658993.1">
        <property type="protein sequence ID" value="XP_050514950.1"/>
        <property type="gene ID" value="LOC126890143"/>
    </dbReference>
    <dbReference type="GeneID" id="126890143"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF36">
        <property type="entry name" value="EG:BACR7A4.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="525" mass="58235" checksum="F03D520E973E50FE" modified="2025-10-08" version="1">MEMDFTLKQILNEKPNEQGSPVDEIKHKANFEEAIVATGFGKFNIYLLILLIPASFVQAFEQMGLPYALPIAECDLNLTLERKGLLSAVSFGGMITSGVFMGIICDIFGRRKLILWGYFLNGLANIVAALSQNFVMLMVAKFFCGFIFNGPFSASITLLTEYHASSYRSRVQLFRGVTFSLGFLLLPLIAWTILPVYINYKIFGFLQIHSWNIFLLCCSMVPFLSAIGFYVIPESPKFLMSKGKNKAALEVFQKLYRWNSGRSSADYPIKELKEEECTIRGNQGQKASVLIAVNKFFIHLKPLFKPPAVFHLILVCTAAYMLTLSMGLFKLWLPQILQHSNSFDTSSNSTSFGVCNMINALAKPKTESTEVCHVVINTSVYKNSMIIAGPQILIFAVSGLVVNYLGKTKLIAILCTISSMSAIGLYFAPNTELLITLFAIYIPFVDLARLTAAAITLELFPTHFRTLAVSFHLMTGRLGSITANTLFSSLVSTGCITPFLLCCILTATITIMTNLYPNTENKGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5KYL2</accession>
    <name>A0ABM5KYL2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515279.1">
        <property type="nucleotide sequence ID" value="XM_050659322.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659322.1">
        <property type="protein sequence ID" value="XP_050515279.1"/>
        <property type="gene ID" value="LOC126890415"/>
    </dbReference>
    <dbReference type="GeneID" id="126890415"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45823:SF1">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="289" mass="32083" checksum="22284CE1794F77E0" modified="2025-10-08" version="1">MPSLSKLTIAHLRLELEERDLSSTGKKADLVERLKNALKEEGHDPETYVFEDKHAALISSITSLESKVSSEISQVSTDITSLESKVSSEISQVSTDITSLENKVSTEITSLEKKVSSEISQVSSDVLKVSTDIASLEKKVSGDISSLDSKMTNEISRVTSDFDDKISSIKSTFEEKIKEIEKKMQETEKVDKGMEPILTDIKNDETKNKLEPQSIVEVSVSLARVKVPNFDGKSSWNNYMKQFESAARANGWSEKEKAVNLTIALRGDALDVLQTIAVEETDDFEQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0E7</accession>
    <name>A0ABM5L0E7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050515910.1">
        <property type="nucleotide sequence ID" value="XM_050659953.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515911.1">
        <property type="nucleotide sequence ID" value="XM_050659954.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050515912.1">
        <property type="nucleotide sequence ID" value="XM_050659955.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659953.1">
        <property type="protein sequence ID" value="XP_050515910.1"/>
        <property type="gene ID" value="LOC126890769"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659954.1">
        <property type="protein sequence ID" value="XP_050515911.1"/>
        <property type="gene ID" value="LOC126890769"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050659955.1">
        <property type="protein sequence ID" value="XP_050515912.1"/>
        <property type="gene ID" value="LOC126890769"/>
    </dbReference>
    <dbReference type="GeneID" id="126890769"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717:SF1">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050515910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="401" mass="46522" checksum="F48718760F397508" modified="2025-10-08" version="1">MFPFGYVLVTIIIILGAVLIKHGTKEQPKKIFNVYAQKGKWYYLKYIIISLVIFIRRIKYYVYGKDNVEKIHNMEKLQMLSSHNLAFDAVYFQAASQTGEYFCGGIERRHGGKIVGLFYIVHPDYGLLESEELPNTIMDATVLSLYNQDSFSGGGMTFTPVVPMKKWKIGFNGTMKYQNNPQKRVHVTFEADWISNYDWFFLEVDVPISTLARSLATEEWSEKLFQNLKNVHQRHYEQMGYINGTLEIDGKEYPIVKWDSFRDHSFGFKRDWSLMHRFIYTTLILSNKTKIVLGVVSQPITMSHLEMGFVNHPDGRIHPVEKIDLLLYEHAENGVLPKELSFTFEAEGVSYDVQMEFICEATHYKGSHEDIIITARFVKCVVNGIPGRGFSDWQYNKSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L0Y3</accession>
    <name>A0ABM5L0Y3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516100.1">
        <property type="nucleotide sequence ID" value="XM_050660143.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660143.1">
        <property type="protein sequence ID" value="XP_050516100.1"/>
        <property type="gene ID" value="LOC126890963"/>
    </dbReference>
    <dbReference type="GeneID" id="126890963"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="246" mass="27246" checksum="04CB15EC548F0019" modified="2025-10-08" version="1">MVKPRESKGVVVLTKAKDKSFDELLGELRTDLCGRSDVVVKRLRQTRDQGIVLELGGGREMAETVKGIVSARQGTVTRAVAKGGTVRRELFVNGADGLTKETDIVSAIETFAGRNGTCQVRGPLRKAYGGDLNATVEVDEDIAARLIRIGFIRVGYISCTIKEKIRIARCYKCMEYGHRRSECKNEVLKGCIRCGEEGHTVNDCPEEGHKCINCKVTGHRGNSMECPKFRQLVNTAREETERRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L156</accession>
    <name>A0ABM5L156_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4780 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516170.1">
        <property type="nucleotide sequence ID" value="XM_050660213.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660213.1">
        <property type="protein sequence ID" value="XP_050516170.1"/>
        <property type="gene ID" value="LOC126891034"/>
    </dbReference>
    <dbReference type="GeneID" id="126891034"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031961">
        <property type="entry name" value="DUF4780"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16012">
        <property type="entry name" value="DUF4780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4780" evidence="2">
        <location>
            <begin position="149"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="405" mass="44590" checksum="4ADCBCBFC909056B" modified="2025-10-08" version="1">MDKKELKGKKIQREYTAKSKKKKEGKHSPSTSREAPREAGKSRTGPSDSIVGIHHKEPGGRDDPLRRGLSGAGCRWYLRYLSQGISPETARKKALEHKSQEPASQKRKRTETVISPAQKEVKRKKEEVGEQTTTSVGMSSYAAALKSEKIAILPKGFPENTLSAEQQTLVEEAIVQEMFAGWEHKLQFGGIHFKPGYLVIDCETPQSAEWLRLKVPQIRKWEGGELTTCKGDDIPRSHVVTVFLPRSKGLSAEKLLQLIEVQNEGLAIGRWKVLSAKEEAAGQLLRAAIDELSCAALRKNGCTIFYRFGKIPVHGIKRETEKETPGSSGGLVTTEVEEAPPVPSASRGTDVPGDAESVGDHHSTDLYRDSEDMETAEATNVEEDKDKTLVGGEEGEKETSPQITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L1D8</accession>
    <name>A0ABM5L1D8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retinol dehydrogenase 11-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
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            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516260.1">
        <property type="nucleotide sequence ID" value="XM_050660303.1"/>
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        <property type="protein sequence ID" value="XP_050516260.1"/>
        <property type="gene ID" value="LOC126891095"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
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    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="GDHRDH"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37757" checksum="6FCC43F0E8829759" modified="2025-10-08" version="1">MTLLFVLGCIVGILLIYFAAVLFYIHCEHITCTSDVCLVGKTALVTGGSKGIGYDIALQLAARGCKVIIASRTVDEELRKRIIRETNNPNIRLEHVDMASFKSVRQLASRLKESESKLDILINNAGILHCSDVPTEDGLNETLQVNHFSPFLLTHLLVELLRKSEGARIVFTTSFMAYCHTMTRKGVSRLKFNTFKLRFFNYTNSKFCNTITSDIFAKKLKRWNISCNSYQPGLVKTVIFENSDRSTTNLFDTLLYYSTLYIWQKFGTKVRLTSQAAVQIAIAKEFENVTGNFVGRYFHNIRPRSAYDTKLCEAIWKASEEIVQLKPEEKLD</sequence>
</entry>
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    <accession>A0ABM5L254</accession>
    <name>A0ABM5L254_DIAVI</name>
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        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
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        </lineage>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516517.1">
        <property type="nucleotide sequence ID" value="XM_050660560.1"/>
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    </dbReference>
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            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF25273"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516517.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="268" mass="31350" checksum="A976BB2C16476E09" modified="2025-10-08" version="1">MFKEVIFVPRIIAFNESIVPIGRKHKQFPTAVVWHEAISGRSKEDIISAFYAFFLDNRDVENVILWLDNCAAQNKNWAFFSFCVYLVNSSDVALKSLSLKFFEPGHTFMSADSFHHQVEKPLKQMKKVFDFEDYKDAVQKANSSKVKLIEMKINNFFNWEDKSSQYKLSRINPRPYLNNMVQVDFERGNQSLSYKCTFNEQEAIVLNFLVAKHQKNGLEKPKSKIDYRGISQNRKDTLINRLRGIIPITRMNFWNDLPVSENPVTEDE</sequence>
</entry>
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    <accession>A0ABM5L2A2</accession>
    <name>A0ABM5L2A2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516567.1">
        <property type="nucleotide sequence ID" value="XM_050660610.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660610.1">
        <property type="protein sequence ID" value="XP_050516567.1"/>
        <property type="gene ID" value="LOC126891434"/>
    </dbReference>
    <dbReference type="GeneID" id="126891434"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="266" mass="31830" checksum="B560EA7EFDFA3C22" modified="2025-10-08" version="1">MKRGRNEHNSSQEEQEFLRESKLVARSPQHKEKVKQPESSMDEIKQMLRDLKKDLHEDMAQIKREIKNDIREMREDIKDTKEELQKNREEMKSMAKEITQMKEEWRREKEALHNKIKEVEDKMERMEKQKIRNNLTITGLTTNTDNEDTLEEALEKMFQTELLLKTKIRRAQKIGQDRCIVEMVEWNDKIKILQGKAKLKGKDIFIDSELTRNEQKIQKNIRDIGREENKKGAIVKVGYQKLEVNGKKMKWDHMSQKLTEANKLKN</sequence>
</entry>
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    <accession>A0ABM5L2I2</accession>
    <name>A0ABM5L2I2_DIAVI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516643.1">
        <property type="nucleotide sequence ID" value="XM_050660686.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660686.1">
        <property type="protein sequence ID" value="XP_050516643.1"/>
        <property type="gene ID" value="LOC126891509"/>
    </dbReference>
    <dbReference type="GeneID" id="126891509"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
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        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="191" mass="22098" checksum="7A59188B2A93D3A9" modified="2025-10-08" version="1">MHHKQSTTHQERRTMHHEPQTNHHAPSNTKQAPPTKHQAIRTKHHEHSTTHQEPSNKQHAPRSTNQAPRTKHHEQSTTHKAPSTTNQAPRTEHQALRNKHHAPHTNHHFPRSLHYEPSTTHQSQRTKHHTPSTTPQSPRTKNKAPRNKHQAPRTNHKALRTKHHEPSTTHLAPRTNHHSPRTNHNASSTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L2L5</accession>
    <name>A0ABM5L2L5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
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            <taxon>Diabrotica</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050516678.1">
        <property type="nucleotide sequence ID" value="XM_050660721.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050660721.1">
        <property type="protein sequence ID" value="XP_050516678.1"/>
        <property type="gene ID" value="LOC126891545"/>
    </dbReference>
    <dbReference type="GeneID" id="126891545"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1886"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1886"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1917"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1935"/>
            <end position="1949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050516678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2058" mass="236611" checksum="A135A1801EC8347E" modified="2025-10-08" version="1">MSFIKSRASDSCPLFGNAKDICVDSSVQLPTYQDMIQCYESVRRELKGEGSKQPSASEIANTVAKKVKDIWIRASLPVLGHTRICEMIVAYNKKYRTILKPFKSRKTPFLDEKLNKFKLDSLKIFDICACKCVNLKNCKCDKSRKIPEVEWEFITDQRNDRRMIIGGIDKVKTAQLNKQMLRKEKEAKRYTKNETDFLLRNHKESLPGTSGTQKVTDIITDSDLNETSSESSLVEDSEEEFKCPYVDKPKRLKILKTKQQMRTPLPCTAQIADLTGASNRTVAKIASAVLEDMKIIAPDKLSNVIDKNKVRREIEKNRKALQQIPLAITIKGLYFDGRKDKTLHQVDGRRTTKLEEHISIIQEPGSIYFGHVTLQTSGTAEHIFNGLISSLEKQNTDLNEVVVIGSDGTNVNTGWKNGVIRKIESHIGKPLQWSICLLHANELPLRHLLQELDGITKGPYTFSGPIGALLKECETRSVVKFESISCVLPVVIQQDLSNDQQYLYNICLAINAGYCQESLANKTPGKMSHVRWLTTANRLLRLYVSTNDPSENLRVLVKFIIKVYAPMWFQVKSKPVIEYGAIHLWNAIKASRELLGNVQNIFQRVISTNSYFLHPENLLLAMLFDSRDHVRELAVRRIIKARKQKSTEVVRYFKIPDIQFDADDYIFLIDWQKCFLSEPPLTTKLTDDFLLKLIKDKRAPDFIDRFPCHTQAVERCVKIVTEASEKVCGETTRDGYIRAKLNARKKLPEFENKNQLLTMEYINGLLKSFEAEVPAYLKSLLIYNGFDNLYSLSQFNIDEDIERMECYARDVLSKVLKGEEKKAMKNQKKNKLLKRPLLCERSEGCPAEKTFPKKRRTVTNKSTSRSESGNEGDGFCTPNDGCVSQDEEQVNYAMQHVLNISRSYIDKFSRNEFDKGKISEERLQDVLNNSKNLKVKMDGEFTAKISCPLCTFISSAYSVKNSKTGRKWVISNFLRHYKIHFKDDGTNLTKKLPIKPQKPEIQTTILNFIKKDANKKCDLNQDFEDPRGNLFDLTDPNTDLNYGASTSSGLHLELTTELSQNDSFIDQNYEIHDEAQQNNPNGVFLHYNTDLDTDSPTDNQSSSQLRTIVVNDFSTEEHQGASQVVNDIPVSELEYNPDNSSPSEDFFFLDNVAEINQSNNGSEKVKSPKAKSLFDDSNSRRERSLRILNELPYHQTQITTFLNTINHAIDNNPEVTNTLSILTENQGINKFNYGTKGLLKYLLDSAIRNSKNKSGHTNKFDDGMKRFWLYIFISAGRMSYEILHSNLKNILHSVTTIHRQLEEMNNILEGEVRIEDLKLYLQKRNYPPIIFISEDQTALIKKVQYDSASNQMVGFVAPLQEQTRFPRINKFPVDSVSDIENAFKNKTLAINAYIFMAQPLVDGSPAFCISIFGSDNRFTSEDVYKRWQYLIKEAGKHGITILGFSSDGDTRCLKSMKIISKLSFTSLNPYSPYFQANYNLENPAVFQDTIHISMKLKTRLLNENISMNMGGKRVSIDNIRYIIENYPRDKHLLCKSFLESSDKMNFNAIDKLSSEHVTNMLKEVPNAEATRQYLILTRNILDAFLLKEISVERRVYLIWYSTFFMRIWKAWLKKNGENIQKNFITTNAYTCIEINAHGIILVIEKLRQNGISEAFLPWLYSSQPCEKVFRETRSMSSTFSTMINYTLLDVLRRLKRIQAMHEISTDLGPNFRFPRQENKRLGNNSSVFKVTEFPSTDEMINIIKKAQEDALSDAKKIGMEMNRDCCIEINLPTCDNPEEQEEVQGSIIITDTISKEHEPDLEPDFSNEDREFLEYTSTFNNYDSLHLRDYTGQKKAQKSCLSVTLKDKKTRIIKKSTLIWFFQEKQGRLSTDRLLRVKGMTVKNTHKGLSKKKQFRKKPGQGLQPAGNIKKRKMFRQPHERAHKDSTSESRSESDEISLESETLSEDFSDLEDCHNESTKMPVIQLESYYAVFYDTQWYLGRVINSYSSEKFKVKFLQQDLDTFKWPKKDDIQDVHKEFIFYGPVSLSGTEPFSLKRNDLIAIKQKYKTIKSIKSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L3U0</accession>
    <name>A0ABM5L3U0_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517116.1">
        <property type="nucleotide sequence ID" value="XM_050661159.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661159.1">
        <property type="protein sequence ID" value="XP_050517116.1"/>
        <property type="gene ID" value="LOC126891838"/>
    </dbReference>
    <dbReference type="GeneID" id="126891838"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="3">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="198" mass="22826" checksum="64B0189E5B48736E" modified="2025-10-08" version="1">MYQTSLISSVICHNRHCFELRWNLSKAKNKLRFKYFSITNKFCQLENQNPNVYKTTDDRTATLDEEDDTVVDEFDQREIFDLIRDINDPEHPLSLEQLHVVQENLISIDNGKNSILINFTPTIPHCSMATLIGLSIRVKLLRCLPSRFKVRVEVTPGTHNAEHQVNKQLADKERVAAALENSHLIKVINQCIASRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L5W9</accession>
    <name>A0ABM5L5W9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517833.1">
        <property type="nucleotide sequence ID" value="XM_050661876.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661876.1">
        <property type="protein sequence ID" value="XP_050517833.1"/>
        <property type="gene ID" value="LOC126892356"/>
    </dbReference>
    <dbReference type="GeneID" id="126892356"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="468" mass="53861" checksum="B82F073B7378B9AC" modified="2025-10-08" version="1">MDAIIKTGFKKINHRITFQPNTESKGKALVLASHVKNVEELRKNGQSNLIQARIIRQTSVTSEPYYAKLYIDDKRLITDVYCNCVYNQSKKCKHVAALIYFVNHEESLTKTDHEQQWGKPSISQISKEKYSKGKFFYEMRMNAKKPKSISKSCDDIDTILTLKNPSPLKLICASMNLDDSKHVIADLLTEITKGVETNLKLEECHVCIENLLLFAAEYPVYSNELDIPNNLKDFYKNHIFLCSEDILKLSCDTLGQAKDKNWFLSRKKRISASKNAHEIKCRKTKTIEKLLSEMISDKTFSSRSTKYGNLNESNARELYEKQFNVQVILTGFTVSMFQPWLNASLDGVVVKNGIILRILEFKCPASCEKKPIVDGRKSNVPYLKYEGGCFLLSKSHMYYTQCQMQMYISGQSICDLFLWSPVGSYCVPVYRDETFIKAVVLQCESFYFIHYLPEVYKLLNKKGNNDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6A6</accession>
    <name>A0ABM5L6A6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_050517968.1">
        <property type="nucleotide sequence ID" value="XM_050662011.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662011.1">
        <property type="protein sequence ID" value="XP_050517968.1"/>
        <property type="gene ID" value="LOC126892478"/>
    </dbReference>
    <dbReference type="GeneID" id="126892478"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="9">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="8">
        <location>
            <begin position="122"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="7">
        <location>
            <begin position="187"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="264" mass="31274" checksum="584392B488AB5AB8" modified="2025-10-08" version="1">MANDREILREIWEGKLPICFRLDSEEVADVREPDPFYLMVPRLSYFPLVTDKIKRHFLKYVDCEKSEQEMWLEYNGQPLKWHYPIGVLFDLSFDKDEILPWNIIVHFDKFPEAEIFRFSNKDMVEAYFMSCLKEADVLKHRGQIAGSMQKKDHNQLWLGLQNDKFDQFWAVNRKLMETTNDQDHFKYIPFRCYMDSGYKQKLVKPVTEGGAKKTLQDLINEIFPENGDVKVKTHGLIPPSDTPLQWLSEHLSYPDNFLHLCVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6C9</accession>
    <name>A0ABM5L6C9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050517998.1">
        <property type="nucleotide sequence ID" value="XM_050662041.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662041.1">
        <property type="protein sequence ID" value="XP_050517998.1"/>
        <property type="gene ID" value="LOC126892498"/>
    </dbReference>
    <dbReference type="GeneID" id="126892498"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="72"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050517998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="481" mass="54311" checksum="8AA7F3A8C3921658" modified="2025-10-08" version="1">MKTFKKATETLKIHNGTKYHNENMIASKHFSLVMDGERADIVCSLNSAQKAVEEENKKKLIPINKTIMFCGMQNIPLRGHRDDGQLLNETDSEPHREGNFRALLRFRIDAGDKQLEEHVKSCGKNASYISKTIQNDLISCCGEVIKNQIVSQITYAQFFTIIADETTDMSTKEQLSICLRYLDKLTLEIKEDFIMFIDVVDLTGENIAQKILEALDSLSINIADCRGQAYDGGSNMSGKFQGAQARIRKIQPLAMYSHCASHRLNLVISKACTIPAIRNAVGVVSSVANFFRESAKRLHALDDERNEEIKKGKHAVKKMCETRWLERHDAVLTFLSSLPSLHATLETMVYSDQAAGNNAFSLLHSILSSEFIVSLVVLENVMTLTLPLARKLQAEYMDVLNAMTLIDATLKSMQEQRANNKECFKRLFEKAQNLASKMGTELKKPRLVGLQRNRPNVQTDTVEDYFRLSIYLPFLIFSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L6F1</accession>
    <name>A0ABM5L6F1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_050518019.1">
        <property type="nucleotide sequence ID" value="XM_050662062.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050662062.1">
        <property type="protein sequence ID" value="XP_050518019.1"/>
        <property type="gene ID" value="LOC126892509"/>
    </dbReference>
    <dbReference type="GeneID" id="126892509"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050518019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="528" mass="60228" checksum="C4991DEB498DCB69" modified="2025-10-08" version="1">MMSNIKKGCYKYCIVPNCTSTTIKTPNKIFFHVPLQTDKRKKWCKLMKRDLIGPKSIKYVCEEHFDIENDTENLIKFKLVGGTLKLKSEIYPHKFDCQKVVKPLRKSGAYEKRRKAECFNEILKDDVPSTSGCQPFEIINCDPIYEEKSVPKDPLSEDCILKSVLGSPKKKYKHKRVQVNIKTPQKNKEVQTVRFRTKKSDMENKRQNICSSPESSPSNMSVSSMSSCSSTSSDSMSNTIKPNFCKDTILKINTNIGFYLGLPEEVYFLTKQLSESIASPVRDILISLKKIRLNDPYIRLAIDFDVSTSLIGKIFNRTVPLIANRMKQFIFFPPMKQIYEKLPISFRKRYFKTVSVLDCFEIRIEKPSSAKQQSLTWSEYKHCNTIKYLISITPDGLINYISDGYGGRASDTIIFEDCDFLLNLSPGYSVMADRGFKNISHLLETKGCHLIRPPSVSANTVSSKLEVMETKRIAALRINVERSIGRLRNFSMVAPHACIDTKVICMLDFIVVIACGMVNVQNKLITCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5L9B2</accession>
    <name>A0ABM5L9B2_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_050519031.1">
        <property type="nucleotide sequence ID" value="XM_050663074.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050663074.1">
        <property type="protein sequence ID" value="XP_050519031.1"/>
        <property type="gene ID" value="LOC126893126"/>
    </dbReference>
    <dbReference type="GeneID" id="126893126"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050519031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="192" mass="21432" checksum="FFBBBA2163C3C3E4" modified="2025-10-08" version="1">MAATAAPHIPRRLFITDSVLQLQFLIDTGADLSVLPRKICTATRPSTVCLYSATGSCIQTYGQRQLSLNLGLDQPVTWTFVVADVTTPILGADFLTHYGISVDMRNKRLVSSNMSSSITCVSRRVKVSEVGLSTAHPYDRPAATIPEDTERVQHYIETRGQRVKKTTHYHYRIIKDEEVEQLNFDSINMAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7EYZ3</accession>
    <name>A0A6P7EYZ3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC114324821</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028128494.1">
        <property type="nucleotide sequence ID" value="XM_028272693.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050504204.1">
        <property type="nucleotide sequence ID" value="XM_050648247.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7EYZ3">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648247.1">
        <property type="protein sequence ID" value="XP_050504204.1"/>
        <property type="gene ID" value="LOC114324821"/>
    </dbReference>
    <dbReference type="GeneID" id="114324821"/>
    <dbReference type="KEGG" id="dvv:114324821"/>
    <dbReference type="InParanoid" id="A0A6P7EYZ3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F248</accession>
    <name>A0A6P7F248_DIAVI</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="gene ID" value="LOC114325164"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Neural_cell_adh"/>
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        <property type="entry name" value="NCAMFAMILY"/>
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    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027595628" evidence="12">
        <location>
            <begin position="23"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
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            <begin position="117"/>
            <end position="214"/>
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            <begin position="221"/>
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            <begin position="314"/>
            <end position="414"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="510"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="612"/>
        </location>
    </feature>
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            <begin position="629"/>
            <end position="732"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028128937.1"/>
        </source>
    </evidence>
    <sequence length="867" mass="97731" checksum="73EEBEB2650CD751" modified="2020-12-02" version="1">MKNTICWQLYCVFFLIFAATNGQQPRLEIQPSGSVVTKEIGGSLVLTCRPKVPDPSLVTSLEWKDKYDRKIDSFNRASPIYVQNLPGEPGIILIFSSLTENQAGKYTCSCFYANTEPLSASVEVTTYEDISFVDAPENQYSIAGQDFKVKCKTKGNPTPTIDWNKNNQAIQTNEKFVVDTDELLIKNVTEADDGVYTCTAIETFTGHIKTRNIKVEVQVPPKIEPIEPVTIIEGDTASIKCLATGKPPPTYQWIKLKTREDLSTTDRFEVKKNTGELIVNRIEFVNDDGLYKCIAENSVARVETTVRIDVLVRPRIYELLNVTAPVSRQTEIICKASGRPIPKITFRKLNRKDSFKLGRQPDDDRVILEQLRISDNGESLGKLIISNLSRPDDGLYECIAENTVGKAYKNGHITVEFPPTFARTKDLPPVWSWDNRPGNLTCLPEAIPNATIMWKYGDIEIHDNNNFKKIGNGPVSYLIVTPYNDRRFFTQYECIAQNKLGLASIKLQLKQAFVPEPISQAKPEFITATSIKWSLIPANNFDGLPLRSFTVKYKPERQLSWDYARNYTWSYGAPYILENLVPEETYHFQFAAKNDVGMGAFANAPTITMPRRSAPSEPKMILENNRIDPDGNNRDIVVPSPYADHFEIRWSVPNDNGDRIMNYFIRYCVTEKVNGNWQDRDCVEQIERSTQYTSYELHNLHSDTIYKVEVRAHNSIGESLPAQVKFRTARGFDPIAPVRHPAMSSAAIIGIAVAVIIVVLIVMDITCFFINKVGIIALCFNSRSKQSDEDDPKLGSLYSWRFPVPYCSYKAAPAHPSSLNLPQPIKLTTSPIDEREPLHEVNPTTVEFDGKSVQTKSGEFIGKHSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F2C3</accession>
    <name>A0A6P7F2C3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 70 A1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114325608</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129511.1">
        <property type="nucleotide sequence ID" value="XM_028273710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F2C3"/>
    <dbReference type="FunCoup" id="A0A6P7F2C3">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028273710.2">
        <property type="protein sequence ID" value="XP_028129511.1"/>
        <property type="gene ID" value="LOC114325608"/>
    </dbReference>
    <dbReference type="GeneID" id="114325608"/>
    <dbReference type="KEGG" id="dvv:114325608"/>
    <dbReference type="InParanoid" id="A0A6P7F2C3"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028129511.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="71431" checksum="797894CEE40C64D3" modified="2020-12-02" version="1">MVKVPAIGIDLGTTYSCVGVWQHGKVEIIANDQGNRTTPSYVAFTDTERLLGDAAKNQVAMNPSNTVFDAKRLIGRKFDDPKIQQDIQHWPFKVINDCSKPKIQVDYKGERKTFAPEEISSMVLTKMKETAEAYLGTSVRDAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLKGEKNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFADEFKRKFKKDLKNNPRALRRLRTAAERAKRTLSSSSEATIEIDALFEGIDFYTKISRARFEELCSDLFRGTLQPVEKALNDAKLDKGQIHDIVLVGGSTRIPKIQQLLQNYFSGKPLNLSINPDEAVAYGAAVQAAVLSGETDSKIQDVLLVDVAPLSLGIETAGGVMTNIITRNSRIPCKQTQTFTTYADNQPAVTIQVFEGERAMTKDNNRLGTFDLTGIPPAPRGVPKIEVTFDLDANGILNVSAKDTSSGNTRNITIKNDKGRLSQQEIDRMLSEAEKYKEEDERQKEKIAARNQLEGYVFQLKQAVQDCGDKLSSEDKSAIERECENCLKWLDSNTLADKEEYEEKQKELTKVCSPIMTKLYQGSRNNNQYSGEMPGGCGQQYGGFGGRQSGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F4W8</accession>
    <name>A0A6P7F4W8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid-binding protein, liver-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114325966</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129922.1">
        <property type="nucleotide sequence ID" value="XM_028274121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050503321.1">
        <property type="nucleotide sequence ID" value="XM_050647364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F4W8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028274121.2">
        <property type="protein sequence ID" value="XP_028129922.1"/>
        <property type="gene ID" value="LOC114325966"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050647364.1">
        <property type="protein sequence ID" value="XP_050503321.1"/>
        <property type="gene ID" value="LOC114325966"/>
    </dbReference>
    <dbReference type="GeneID" id="114325966"/>
    <dbReference type="KEGG" id="dvv:114325966"/>
    <dbReference type="InParanoid" id="A0A6P7F4W8"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028129922.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13693" checksum="16D8BA0812FC0374" modified="2020-12-02" version="1">MVLSGKYSVIGEENFVQYLKDYGIPEEQIKNSGQFSIEFKQDGNKVIVTESAAGKSKVTSFTLGEEFEEERFGHKIKSNAKLEGDILVITNGDHSRTFNFTSTGLEIVHKSPKGSAKLIFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7F885</accession>
    <name>A0A6P7F885_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synaptic plasticity regulator PANTS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Plasticity-associated neural transcript short</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC114325946</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="8">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synaptic cleft</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0545 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028129903.1">
        <property type="nucleotide sequence ID" value="XM_028274102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7F885"/>
    <dbReference type="FunCoup" id="A0A6P7F885">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028274102.2">
        <property type="protein sequence ID" value="XP_028129903.1"/>
        <property type="gene ID" value="LOC114325946"/>
    </dbReference>
    <dbReference type="GeneID" id="114325946"/>
    <dbReference type="KEGG" id="dvv:114325946"/>
    <dbReference type="InParanoid" id="A0A6P7F885"/>
    <dbReference type="OrthoDB" id="5946508at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043083">
        <property type="term" value="C:synaptic cleft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028129903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_028129903.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="19281" checksum="B971489055485913" modified="2020-12-02" version="1">MEEGIKEENKEQTNKNEDKPETPKVENDWMIRKCFIYDEEYSDCTSLKARFNQYFIFGKSIDCSQWKRDSINCYKWENDKDVNAANELVKSEKQKRKERLLPHYKNDVWTKRTSPPENWNCPLPDYITKEYENSYLNIKSKEMKGEIPPSFDMDFKCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FDI7</accession>
    <name>A0A6P7FDI7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 85C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114328947</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC85 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028133741.1">
        <property type="nucleotide sequence ID" value="XM_028277940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FDI7"/>
    <dbReference type="FunCoup" id="A0A6P7FDI7">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277940.1">
        <property type="protein sequence ID" value="XP_028133741.1"/>
        <property type="gene ID" value="LOC114328947"/>
    </dbReference>
    <dbReference type="GeneID" id="114328947"/>
    <dbReference type="KEGG" id="dvv:114328947"/>
    <dbReference type="CTD" id="33509"/>
    <dbReference type="InParanoid" id="A0A6P7FDI7"/>
    <dbReference type="OrthoDB" id="10056395at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019359">
        <property type="entry name" value="CCDC85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546:SF15">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546">
        <property type="entry name" value="RE60986P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10226">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028133741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028133741.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49912" checksum="9441690E8491BDA9" modified="2020-12-02" version="1">MSNKKAGVKTNAEPAVLPPRYQPPPMPTGQGILKNSPTEPAKKPPKTGENVKLLYPNDPHAKFFPNPQARIHQYPPPLRQIPDEVRTTQLQIHHENPPPRPRLPEESGAQQIHLDLRVPQQRQPIRYDDEFLRPEMLKFVRKPDDPRFIDPNRQFQGILLELRSLKEANQHLADDNQELRDLCCFLDDDRQKGRKLAREWQRFGRYTASVMRQEVSAYQTKLRELDNKQQELIKDNLELKELCLYLDEERGNGSLCPSCGNNAGGNLRDDGDGSSSSTNADEPAVPQQFSSGANPQRRSESRERILHENLARQRNTFNDQIMQYVRSLEQRVKQLEEDKRALTHKINQIATTTGDPSLAAPQDLGGGMLTGRPEAVVRALQVLEVREQLERESHELGVENMSDTTSQDMDDGEKALVREMCNVVWRKLEDPNTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FFA5</accession>
    <name>A0A6P7FFA5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-nitrophenylphosphatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114329719</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134704.1">
        <property type="nucleotide sequence ID" value="XM_028278903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FFA5"/>
    <dbReference type="FunCoup" id="A0A6P7FFA5">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278903.2">
        <property type="protein sequence ID" value="XP_028134704.1"/>
        <property type="gene ID" value="LOC114329719"/>
    </dbReference>
    <dbReference type="GeneID" id="114329719"/>
    <dbReference type="KEGG" id="dvv:114329719"/>
    <dbReference type="InParanoid" id="A0A6P7FFA5"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF4">
        <property type="entry name" value="RE04130P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028134704.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34761" checksum="2FC0BCFE59E42A55" modified="2020-12-02" version="1">MCVLKNLTEASKEEQVNYINSFDEVLLDVDGVIWLNFNPVQGAVDCVSNLKKLGKKIRYVTNNTLSLTQTIAKNLTDRHFVTNAEDVVTPKETTIAYLDQLNIKDKHIYIIGSIIMKETLRNAGYKLIPDPPVEIKEGLANTLSYYDDANVGAVIIDFDFNFNFIKVQKAFWYLNRPNTAFIMTLGDRLIPVGPKGPIISQYFAAHALKEVTNKEPILMGKPSDMCVNFIKESFNIKDCSRTLFVGDSIASDMAMGAKAGFQKLLVLSGISSIEDIRDWKHPEEYKPEYYISSLNDLNNIIKEHFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FKR0</accession>
    <name>A0A6P7FKR0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA cleavage complex 2 protein Pcf11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114331281</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028136601.1">
        <property type="nucleotide sequence ID" value="XM_028280800.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7FKR0">
        <property type="interactions" value="1633"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280800.2">
        <property type="protein sequence ID" value="XP_028136601.1"/>
        <property type="gene ID" value="LOC114331281"/>
    </dbReference>
    <dbReference type="GeneID" id="114331281"/>
    <dbReference type="KEGG" id="dvv:114331281"/>
    <dbReference type="CTD" id="51585"/>
    <dbReference type="InParanoid" id="A0A6P7FKR0"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048830">
        <property type="entry name" value="PCF11_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20845">
        <property type="entry name" value="Pcf11_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028136601.1"/>
        </source>
    </evidence>
    <sequence length="1711" mass="190603" checksum="3DC67315D086D874" modified="2020-12-02" version="1">MSSSEEIKAEYMSSLADLTFNSRPLINVLTMLAEENSPNAPVIVEAIEEHLSKVNTDVKLPILYLIDCIVKTVGGIYTSLFNHNIVNMFIGVFKAKLVKDTHKNTPFKVDEKTRAEMFKLRQTWNEVFPQMKLYAIDVQISLLDPAWPVTAKPPSNSIHLNPRFLKNAPPSSTPTIKTEPESSPSDSASPSVNKETLIMQEQLIQKQRELLELQQKKLELEVLQTRVKLQEQYKNNQPQTGRPHNILLKPEVAKQLVPSLAQHKQNLVNTAMVQQLAQPQAAPTNGTKINPVSSALINAKPIRDPRLLRQQQKRDQTPSADGNLENQLHQRTALLETNKIVSNKNSVRKHRNDPRLINKDDTSNQRSDSSKPNHSSKSRSSESAHHKSHKTSRSSSQRGQDTSSLKSSSNSVSIDSSKVKSDLVKSPVKNKKKEKSDRRPLSREKPGKNDSSPVSNSTTFKNVSMAMKNRNYVRKKVGSASPEAVKDEDLRSFGPPEKQPRLESDSNDTISAAPVSKAVEPLPVAVMPPSATMAPKTQSTILPTSAKDQDVDLRQLPAMVTKKRSSTEISEDVSMPAKKTKTQIFDKLFGDEDTDLRQQLAINTEQRPKTPPPPIISVSATETKTASPKMGSPKSNFDAVRAKLANATNRDKVLSKSYKKKPKLEDQDLRPQATTGSPHKTKIIISPEEETSIKSGKMTNEEGSELLNRIILQVEKRKLKEAKRKDHEESFNVSLQPISDDDLSDTELEKEETNTEGPVDAVMSNESVPERPPISEESLIPFKDKDERLNSGPPPPPSEFVGHFFPRDGRDTRRFPGPHWRGRGGRRWEPIQPMMSARPWNSNNWAPVEEFTPALEEMEPIFPNGHVNADEVKSITIDSVSRDIRFYGETAIVFIGWDDPRELTFQNAGVRKITFNDKDSFVLNFNDDYKEVYCNGNSHIVRLGAPSRELFIDNVPYECFFGSPGIRIELDGVPTKVHLEGPPPPVNIGKVKRCDLVAGKINMFVDAIHVVPVFLDAKVQKFVLQGQTSTLKFVDALKTVLINDVPFDIEYGGLPKPLFIHGKKHFVRFSVLPRDIRPGKVRLLDMDFPEDTRAADENSQDVPLVTDAYDPAMPISGTMDKPVGSDSPDRNSNSPNSVLKSIQQNNLDVLSNALSSSTGPAPVSGGYQIENQNSQDSQASSQPFTTLPPILNINEIFQNLVASGLVKSSPPSKPVEEPPKVVESPKKEMRIEPEVPAATSTPNVAPSKLKKTVLSLKPVTFNRPETLRVRQNSLYAMLYSGMQCSTCGMRFSPEASMLYSQHLDWHFRQNRRGKRNSRVATSRRWYYSLADWKNYEELEDLEEREKNYFDEQKQAEGGNEDAEEEVEVPSVAADPDSTDECCMVCREKFDQFFNEEKEEWHLRNAIRMENKTYHPVCYEDYQNSLLEQTLDESKAPEEIEQPQEESVEKIIPGLEIIIDDDDDIPEEVNGPLSNEILSVESDDSKLVPEATEMPEYEQQEAAAEGDDDDDVILNEVAPIKIVVDDDDDEIAGERTNVASPPPAMDTEDDGFVEIAGLLSLPNGKHVKIKAEPVDKEDIPTTPVAEDLSTLTVESSDLEIVEPKPTQHDVASSLDGNADPFSGVTAVGSAALGGNKIKINISKPLPVINKEKENNLGNDLVPSETYIDPFEPFPPGEEPQPAALKTALRSARLSKLPPVRKGTELTGLCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FPU2</accession>
    <name>A0A6P7FPU2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fork head domain-containing protein crocodile-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114332701</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138329.1">
        <property type="nucleotide sequence ID" value="XM_028282528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FPU2"/>
    <dbReference type="FunCoup" id="A0A6P7FPU2">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028282528.2">
        <property type="protein sequence ID" value="XP_028138329.1"/>
        <property type="gene ID" value="LOC114332701"/>
    </dbReference>
    <dbReference type="GeneID" id="114332701"/>
    <dbReference type="KEGG" id="dvv:114332701"/>
    <dbReference type="InParanoid" id="A0A6P7FPU2"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF388">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="61"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="61"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028138329.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41078" checksum="D583C39A31DBE26A" modified="2020-12-02" version="1">MHTIFSEHPTAYNRYSSYSSSASAAITASNPYAYEQYSRYGYPSPWHHQQHPLSTAKDMVKPPYSYIALIAMAIQNAQDKKITLNGIYQFIMERFPYYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFDNGSYLRRRRRFKKKDALREKEEQLKRQQIQSDSPINKREEKPLEDIKSKLECKPKREPNTELSHCMSTKYGDPKSVIVHQEHVMSDVTASLQAMDSAAAFSVDSLMTSREQAISYSNSARLHSSGGMYSYCPSATPQHQYSIADEAAPRYSPWYSPETSPESATSYRDIIFDNSAAPSCQLAGFRHPGVTPSPPNYRTTAAYYQSTDCVGQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FR88</accession>
    <name>A0A6P7FR88_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Potassium voltage-gated channel protein Shaker isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC114333205</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028138869.1">
        <property type="nucleotide sequence ID" value="XM_028283068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FR88"/>
    <dbReference type="FunCoup" id="A0A6P7FR88">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283068.2">
        <property type="protein sequence ID" value="XP_028138869.1"/>
        <property type="gene ID" value="LOC114333205"/>
    </dbReference>
    <dbReference type="GeneID" id="114333205"/>
    <dbReference type="CTD" id="136038932"/>
    <dbReference type="InParanoid" id="A0A6P7FR88"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000007">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="16">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_028138869.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="59007" checksum="D1380CA033311F6C" modified="2020-12-02" version="1">MIFLNKSKPGRSLPKLSSQEEDGHTPHTQFTGVAHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTLLGDPARRIRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGELAINKFREDEGFIKEEEKPLPSHEFQRNVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETICIIWFTFELSVRFLACPNKLHFFRDVMNFIDIIAIIPYFITLATVVAEEEDTLNLPRAPVSPQDKSTNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDQEEMQSQNFNHVTSCPYLPGTLGQHMKKSSLSESSSDLVELEEGLMVTRDQLSQKQNCNPRHNNNINAMSIETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FRA8</accession>
    <name>A0A6P7FRA8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LisH domain-containing protein FOPNL-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC114331842</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CEP43 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137317.1">
        <property type="nucleotide sequence ID" value="XM_028281516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FRA8"/>
    <dbReference type="EnsemblMetazoa" id="XM_028281516.2">
        <property type="protein sequence ID" value="XP_028137317.1"/>
        <property type="gene ID" value="LOC114331842"/>
    </dbReference>
    <dbReference type="GeneID" id="114331842"/>
    <dbReference type="KEGG" id="dvv:114331842"/>
    <dbReference type="InParanoid" id="A0A6P7FRA8"/>
    <dbReference type="OrthoDB" id="5970631at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431:SF19">
        <property type="entry name" value="CENTROSOMAL PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="8">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_028137317.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13629" checksum="502B7263C65C0189" modified="2020-12-02" version="1">MGDATENDLLEAIKDSLEKDGTLGRVNGEIRARVMAVLNRDFECADPPKVPEETKLINELIREYLAWNGYLYSEQILIAESGQKNERLSRDVLTTKFGVMDDSKTAKIPLLYYIVSAFQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FT26</accession>
    <name>A0A6P7FT26_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Muscle-specific protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114330882</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028136108.1">
        <property type="nucleotide sequence ID" value="XM_028280307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FT26"/>
    <dbReference type="FunCoup" id="A0A6P7FT26">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280307.2">
        <property type="protein sequence ID" value="XP_028136108.1"/>
        <property type="gene ID" value="LOC114330882"/>
    </dbReference>
    <dbReference type="GeneID" id="114330882"/>
    <dbReference type="KEGG" id="dvv:114330882"/>
    <dbReference type="CTD" id="36468"/>
    <dbReference type="InParanoid" id="A0A6P7FT26"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF24">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028136108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028136108.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20292" checksum="329E186CD90BF148" modified="2020-12-02" version="1">MSLERQVRNKLAAKRDPQQDKEAQAWIETILGAKFPPGEAYEDVIRDGTVLCQLINKLAPGSVAKINTSGGQFKMMENINNFQAAIKAYGVADIDVFQTVDLWEKKDIAQVTNTLFAIGRQTYKHPEWKGPYLGPKPADENKREFTEEQLKAGETMIGLQAGQNKGASQAGQNMGAGRKIILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FTE9</accession>
    <name>A0A6P7FTE9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114333785</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028139591.1">
        <property type="nucleotide sequence ID" value="XM_028283790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FTE9"/>
    <dbReference type="EnsemblMetazoa" id="XM_028283790.2">
        <property type="protein sequence ID" value="XP_028139591.1"/>
        <property type="gene ID" value="LOC114333785"/>
    </dbReference>
    <dbReference type="GeneID" id="114333785"/>
    <dbReference type="KEGG" id="dvv:114333785"/>
    <dbReference type="InParanoid" id="A0A6P7FTE9"/>
    <dbReference type="OrthoDB" id="8122353at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028139591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028139591.1"/>
        </source>
    </evidence>
    <sequence length="73" mass="7974" checksum="1745CD4BFD4EC9F9" modified="2020-12-02" version="1">MSDNEVDDAPPAPQVQSSCPMDVNQALQEVLKTALIHDGVVHALHEAAKALDKRQAVLCLLAENCDEPIYKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FXN1</accession>
    <name>A0A6P7FXN1_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Pickpocket protein 28-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114335300</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028141319.1">
        <property type="nucleotide sequence ID" value="XM_028285518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FXN1"/>
    <dbReference type="FunCoup" id="A0A6P7FXN1">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028285518.2">
        <property type="protein sequence ID" value="XP_028141319.1"/>
        <property type="gene ID" value="LOC114335300"/>
    </dbReference>
    <dbReference type="GeneID" id="114335300"/>
    <dbReference type="KEGG" id="dvv:114335300"/>
    <dbReference type="InParanoid" id="A0A6P7FXN1"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027565357" evidence="14">
        <location>
            <begin position="33"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028141319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028141319.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="70554" checksum="628C5431EF549B86" modified="2020-12-02" version="1">MNCRMKINIPTNRNNFLVLKLIYFIFLTKIMTVPEKEANGTDVENAAQQKEQEVQKEKELLKAMRKSKRKFPGFRKNLYDYFQEFTGNTGIHGFKYMGEQERTTCERFWWVILFCISLYVCVDLIIKTWLKWDQSPVLVSFARSPTPVWQVPFPAITICSETKARQTVYNFTQAYNRFIQYPENMTAEEMKRFSDSSLICDNHLYTEGENVTEFKTIEYLMSIAPQFVDSFFSCKWTLLNESCDNMFTPMLTEDGLCFTFNMLDRTELLREKVYLHGQYMTHGRHSEGWSLEDGYPKTAKKDTFPRRAMSAGLSAGLYLVLKAYEPDLDYLCRGPVQGFKILLHHPAEVPRVQLQYFRAPLNHEVVVSLKPDMMTTSEGLREYDPHRRQCYFPSERYLTYYKSYTQQNCQVECLTNYTLAKCGCIAYHMPHVKDTPICGSGSQKCMFEAQTELLTREVESGIENFETETRDAVNDCDCLPACTSLTYNAEYSQAKYEWEKLFQAFRVNFSEFPGIQLTRLTVFFKEQQFITSERNELYGQTDFLASCGGILGLFTGFSFLSIVEIFYFLTLRLMCNVKHYGRHYWSASPRLVNDPAYVHPKIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FYZ6</accession>
    <name>A0A6P7FYZ6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114332204</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028137755.1">
        <property type="nucleotide sequence ID" value="XM_028281954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FYZ6"/>
    <dbReference type="FunCoup" id="A0A6P7FYZ6">
        <property type="interactions" value="1175"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281954.2">
        <property type="protein sequence ID" value="XP_028137755.1"/>
        <property type="gene ID" value="LOC114332204"/>
    </dbReference>
    <dbReference type="GeneID" id="114332204"/>
    <dbReference type="KEGG" id="dvv:114332204"/>
    <dbReference type="CTD" id="6152"/>
    <dbReference type="InParanoid" id="A0A6P7FYZ6"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TRASH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028137755.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17571" checksum="3B965F3873C3E021" modified="2020-12-02" version="1">MKIGLCAYSGYKIYPGHGKTMVKVDGKTFTFLNSKCERAHLMKRNPRKVTWTVLYRRKHKKGQEEEATKKRTRRTQKFQRAIVGASLNDIMAKRNQRPEVRKAQREQAIRAAKEQKKSTKTAKKATAPAKAKPAPKQKVTKNQPKAAPRVGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7FZX4</accession>
    <name>A0A6P7FZX4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC114332443 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114332443</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RFX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028138040.1">
        <property type="nucleotide sequence ID" value="XM_028282239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7FZX4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050652659.1">
        <property type="protein sequence ID" value="XP_050508616.1"/>
        <property type="gene ID" value="LOC126885871"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7FZX4"/>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000128">
        <property type="entry name" value="DNA-binding protein RFX5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF21">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="126"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050508616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028138040.1"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112623" checksum="7190200F74180414" modified="2020-12-02" version="1">MENDIRTDKYQSVPSDTEKLENDLNNGTAAGNGENVEDSECSQTINEQEGNDSNGKECHKDNDLINITISEKAKNIINSILEQIKQLSQVEKFLLFLKLPSEVTNAVDPFKQTINPLGSRSEITRTISWIKTHLQEDPDISLPKQEVYNEYHNYCANNTIKSLSQADFGKVMKQVYPKIRARRLGTRGNSRYCYSGLRRCTKLKSPLLPDLADKPLFAEGSFSQSSLASAAWLIVKEWSECHFTQPFSSIQCLAYHLILNHLVGTGSEAASKISAAGMSSSKDDGSVKVTKHREMQLQLQRKIQERHEGRERKKRTQSPKSEQKPGVKKSRSQSVPAQNVTTNFSPTTTNGNVNLLSGECSSTTSSSSSTSPTQAKIICDKSLDFNQLPDFNSFQKPAVDGDTMGSSEQDSQLVINTNSNKVQLPKLQAVSSSDLVPCLEMPSPSKKQLKYKSVRPRLQPCDIASYNPQPLILPEAEAEHRSQHNIHDIARIKERNSDDECDVPDFPLTRERLNSVSSVDKDAMDEYLGTNNSQHEEELSKYFCNNNFPETTESEDTSKLSTLRQLLVQNNIVDTKPSILENRVVEPKSVSFPNTCQNQMPVQTNFTHVNPMNFQELSTTNANVKRRVSFEMSATENSVPPSPNTRRKNFSFTPISPGPQSPSGIHSKCSSTSVSPFVSPRSTPVLRSKPAHQNACLKNEIRKYLKVKREIDLTIEIPPENQPGLHSTAMSAPPSPIMNNKSVLQKLLNSTSKVSYNPSYTAVRKIPIPPKTSPEVTQFLTSNVESNLEGYRSRSVPLHNMINPVNSVFISTNNLSEIATIPEQDPDEVKTMLVSGNPPNEPMDIVGMNIVSNNINLREFGFKLFNNGLDGSDFSQQTYASPRLVRSQSINEEISIPQVLPSRSVPSTPLPFNKPPKINYNNSRSYPSTPLNNDETFSYNLNNLNGDCLLNGQPIRSDMVEGLSYLQDIEVNGDSTVEALPHDITTDFDIVENESQLLNAGLIEATFTDNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G1V7</accession>
    <name>A0A6P7G1V7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Spectrin beta chain, non-erythrocytic 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114336756</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028142929.1">
        <property type="nucleotide sequence ID" value="XM_028287128.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A6P7G1V7">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287128.2">
        <property type="protein sequence ID" value="XP_028142929.1"/>
        <property type="gene ID" value="LOC114336756"/>
    </dbReference>
    <dbReference type="GeneID" id="114336756"/>
    <dbReference type="KEGG" id="dvv:114336756"/>
    <dbReference type="CTD" id="38418"/>
    <dbReference type="InParanoid" id="A0A6P7G1V7"/>
    <dbReference type="OrthoDB" id="9942256at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045170">
        <property type="term" value="C:spectrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21193">
        <property type="entry name" value="CH_beta_spectrin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000429">
        <property type="entry name" value="Beta-H spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000043">
        <property type="entry name" value="Spectrin beta chain, non-erythrocytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000135">
        <property type="entry name" value="Spectrin beta chain, non-erythrocytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000145">
        <property type="entry name" value="Spectrin beta chain, non-erythrocytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000279">
        <property type="entry name" value="Spectrin beta chain, non-erythrocytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="49"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="170"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="854"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="3737"/>
            <end position="3845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3863"/>
            <end position="3987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1518"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1974"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2087"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2506"/>
            <end position="2576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2723"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2926"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3350"/>
            <end position="3384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3597"/>
            <end position="3636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3865"/>
            <end position="3876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3889"/>
            <end position="3901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3931"/>
            <end position="3968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028142929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028142929.1"/>
        </source>
    </evidence>
    <sequence length="3987" mass="461037" checksum="1756E9A3C0BF6EEC" modified="2020-12-02" version="1">MSRSPYVASIHYEPKPDPGYQRRNNMSQRDEVQKFEQGRIRVLQEERLHIQKKTFTKWMNSFLQKARMEVEDLFVDLADGKKLLKLLEIISGEKLAKPNNGRMRVHKIENVNKSLAFLHTKVRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIPEDEDNESSEKKSAKDALLLWAQRKTHGYPDVHISDFSSSWRNGLGFNALIHAHRPDLFEFESLKHNKNIDNLNHAFDIAQNELGILRLLDAEDIDTSRPDEKSIMTYVASYYHTFARMKQEEKSGRRIAKIIKQMIDSDKLKLTYDKLTTDLLDWIKLKIVELEDRQFPNSLEGIQNLFIQFGHYRNQEKPPKYIERSEIEALFFNINTQLKELRQPAFYPSDGKLVQDIERSWDTLEKAEHSREVALREELMRQQRLDQLMYKFEKKSILREGYLKEMIQVLSDPRYGSNLVQVDATLKKHEAISADILAREERIHDLSHMAQELINENYRNSDRVQKRESEIIKQWEELKALLEKHKLNLNKMGSIMSIIREIDSVLTSTEQLRIDLSSTDTGAHLVAVEELLHKHALQNLMVTSLEEKESWLNRVGHQTAQGNPKGDEVLKKLKELGKVCEEIRELSAKRKALLEEARNFYQFLQDQEDEEAWLIEKQRICQAGIMAKDLRGVLSLQQKHKVLMDEIKTRKNKFDQLGATSKQLISDNHPRSLEIQQHVDKNKKNWELLDKLAKERAKQLQDAAEAYQFYADANEAESWLNEKLALVTSDDYGTDELSAKALLQRHKVLDEEINAYHGDIYSLNGQADRLVASGISTLDLNNEPEVNEPIEDVQYENRMVPTEVWVDEPVEKTEYKVITEEKKVPQVKALYPFNDHGLSMVKNEVMFLLNKSNPDWWCVRKADGTDGFAPANYVEEIEPRIILVNIRKPEVVKSVQKVKKTKLVNTKVPVKVLRQLPRAQKRKVDDTDSVPKRQKTINDSYAQLQDLAAKRQALLADAVKLFTFYKECDDFEKWIKDKEQLLANDDPNDSIEQAKRKYEKFLTDLSASQKRMDALDADVKVFVNQNHSQIDKVKIRHRQIQAAWQKLNTLKAQKEKSLEGASSVELFNKICEETKDWMLEKMEQLDTAVLGHDLKTIQALQRRHDNLERELSPIEEKVDKVNLLGNSVQKSYPNEKANVIQKQKDIDDLWKKVKDKALERRTRIEDAVGQQIFTNSSKHLLNWVADTKKQLNADNVVRDVQTAEALLKAHQDLAEDIKAKNDEFKQVTGLGKKLLKSNPNLPEVQSVIDRLLAEQEAIARGWKEKDIWLQQCLELQIFNKEADNIDAVTSGHQAFLEFDELGSSLDEVEALHKQHRAFANTLAAQDDRLNAFAKKANTLIAKQHYDAAGIADRVQQVLERRQAVKDASQKRADALDASKNYQEFCAEVYDLRAWMAEKIKTASDENYRDLSNLERKIQKHEAFERELRSNEGQLRTINKLGMALIAQDSYRKNEVGKTLKELNDEWQRLVDTSLQKGRMLRQAVTQHEYNKSIEDVNNKLNEINEKMNSKNVGSDLRSCRELMKHHDALESDIAFCATRIEELRSQSQNLHEEGHFDSPAIIENVEAILRNLQELNAPSQDKRAILEESLEFHKFGFSIDAELQWIKEHLPLASSQDLGQNLHQAQNLYKKHKKLEAEIIGHQPVIDKTLETGQALIDKDHPEEKQIQVLCNTLEEAWQDLKDKTNARAQQLNTSLKAQQFFFEINEVESWLNEKDNVLASTDFGRDRDSATKLLSKHKALELELDTYNNIISEMGHGAQAMIKSGHPESKLIAERQTAIEHLARAIQRKAVTRQQKLMESLFRHEYFVESEELESWIAENLQQASSEDYGQDYEHLLQLQTKFDDLKHRIEGGFERYRQCEDLAQKLLANESPYSAEIENRQDNLEQAWEQLQTQLTSREERLEAAGQIHRFHRDIADALQRIQEKNAALGTDLGRNLNSALTLLRKHEAFENELVVLEAQLQILVEDASKLKKLYPNNKVNIQHQQEVVVAAWNDLKERTDLRRDQLQASVDLQKFLAQVRDLSNWANGLILAMNAEENIRSASRVQVVKSEHEALKSEIDAREDDFQEVAENLAAMEQTGHYAAPEAVEKYKHLIGERDKLLTTWQLRKIHLDQLCDLLVFLRETKLIEDATNTQEAALTHVDIGETVDEVSNQLKKHEEFEKVLQVQDKNLEALFASGNKLLQQNHFESEQIAQRLADVQAKRKKVHQLSEAKRKYLTNGLLYAEFVRDVAETQVWIIEKEKKLGTMTAMTKSDVSDLEDKIKVLQKHQAFQAEVVANAGRIQEIKNNGETLIRKNHKASQDIADQLADLEQAWRRLNEEVSLKGKGLEEAQDILEFNSQLDKIESWIRDKEVLLQAGDTGKDYEHCQILQRKLDDVDSDMKIDDTKIKTITALSNKLAAQGHNHVRERGDNLIKKWHSLQKALNDYRNKLNEASEIHLFDRDIADTLDRIAEKCSIMESEEVGRNLPAVEALQRKQEALENEISAIENKIVNTHQKDAFYLSEKYPYSTKHLEDTLRNLEVQMQKLEAAKLKRRALLQKAHSQEKFLADAKQLEQWVLETIKRMESQEKPNSVVDAEVQLELHNELKAEIAGRDEPFTQLIQYGKTCPEKDNPIIVDNVKKLEELHTKIHRAWIDHKNNLTHSFDVQEFNEQVNQLNNWLADKEAFLNNEDVGDTPRAVEALLRKHNDFELTLQTLLGRVDELKSEAKRITKDTSRNNEEVLLKLETVLNRNDRLLAKTKQRKDTLEKSKALQDFLRNVNDVETWLTQKLQTAADENYREPINLQNKIQKHATFEAEVIASGERIQNVVEVGKDLIAADHYAADEIGIRLDELENDWKHLLELSNLKRDRLNEAYQALLFNRSLEEFETWLTDVEHQLKITGTDDFTSAGNHLKRLATLENDIQQHAENCEIINEGAEQFKKGGHFLADEIDEKVQKAITRYHQLKEPLQVKKDQLELSSMLQQFTRDVDDELQWLDDREPLVASQDLGNNLTAVQHLHKKHQILEGELTSRSAIIDALVARADQLVRSKHPSETIIKDKTEQLNVKLDQVKDLASIRRLRLQDSLEVQAFYQDVSEAQAWIIEKRPLLATKEVGKDEDTAKSLQRKLETLSIEVKTFQKSIQRIVDAADSLIARRHFDAANIEKVKVELQKDFGELRKLVSEREVRLAEALQYFGFVHECNEVQDWMKEQMNKADSEEYGNDLEHVELLIQAFDTFHASLINSEPRVQQCIENGHFIIDAKSSYSPDIQQKIIELQNNWDDLLELANARKEALAGAKQVHLFDQTADEIISWIREKDIDVIYGVYVPDVEVIEDMMRKHQALETEMKAIKDKVDFVEQEGDRLIAEYPDTKEHIDDKREDTVSTLQDLQDKVERQKYFLQQSEQLQSYFDEYHDLLAWINEMLAKITAPDLPQDCIEAELLLGRHKEYSTEIDGRLPVFQQFYETGQTFIKEGHSLSQEIEDKIKILKQKIDLLDNTWKKRNLIYEQNLDLQLFKRDANVLENWMAVREGTLKDGKVGDTISQVEEFIRKHRDFEETIKAQDSRFNALKRQTLLEDSFAQQKLQEARARKEEKERIEQEKLEQRKLKEKARINELRRQESLPRYSLPEDARPVISHEQLEALQQSTQSPAENNNISIRKTNSIAHTFDRDRIRRGSDVSVKRAESMKVGNLVKPVKRTPSFNTRRRGSIRSKNELVLPPVEAEAFLERKQLLLPGQKRATNRAWKHSYTVLCGQLLCFFKTKDDFVASKANAAPLNIHNATCGIADDYQKRKHTFRLSITDGSEFLFASNSEVDMMDWINKITFRAKLPPANQLQHFEITKDPNDFEISSQSSRTSSPDVPDTVVLRQDPHATNGSISSSTNHPYRHTIGGSSSPPPIPPRMTDVTLGYESRLYTSDSSGSVNEGFNNSTPSRGQEWNSTSRPLSSPDSKNVSHRIRDLFVRKKRNSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G2J4</accession>
    <name>A0A6P7G2J4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double-stranded RNA-specific editase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC114333169</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="6">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028138815.1">
        <property type="nucleotide sequence ID" value="XM_028283014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G2J4"/>
    <dbReference type="FunCoup" id="A0A6P7G2J4">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028283014.2">
        <property type="protein sequence ID" value="XP_028138815.1"/>
        <property type="gene ID" value="LOC114333169"/>
    </dbReference>
    <dbReference type="GeneID" id="114333169"/>
    <dbReference type="KEGG" id="dvv:114333169"/>
    <dbReference type="CTD" id="43981"/>
    <dbReference type="InParanoid" id="A0A6P7G2J4"/>
    <dbReference type="OrthoDB" id="6363432at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="302"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028138815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_028138815.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42161" checksum="77E160A117934018" modified="2020-12-02" version="1">MSYSTRRSTGYNTPQTQNVGNVGQRRPVVTNNFVQGQQKPPQQQQQQQVQQNKPTTPATARPQATTPQAGIQFRAQQQTPQANQQAATTQAAANAARLQQQAQAQQIKHDADQSMDATNGSDSTEVKKKPFWANKTGSKVTKRERVRRRNVRLSKILQPKNAVMILNELVRNTSYTVDELSQKYDGNQFKATVLYEGIEHVGYGRSKINAKNTAAEAALKHYVKTNKLTEVKKDDEGNEKMDVSEDDATQAPLPWQHVASFALYKLFSSWGEDLNVNQNQSIPSGEKLHENKPAKKMPENPDTINPLMLVNQMLPQAQFEEIGKTGNPPNVLFSFKCIVDGESFIGTGSNKKAAKKMAAFGACSKVLGIQYPPDVYVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G3D1</accession>
    <name>A0A6P7G3D1_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC114337282</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_028143494.1">
        <property type="nucleotide sequence ID" value="XM_028287693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G3D1"/>
    <dbReference type="FunCoup" id="A0A6P7G3D1">
        <property type="interactions" value="1120"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028287693.1">
        <property type="protein sequence ID" value="XP_028143494.1"/>
        <property type="gene ID" value="LOC114337282"/>
    </dbReference>
    <dbReference type="GeneID" id="114337282"/>
    <dbReference type="KEGG" id="dvv:114337282"/>
    <dbReference type="CTD" id="33938"/>
    <dbReference type="InParanoid" id="A0A6P7G3D1"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_028143494.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="34501" checksum="3180F6E7C09D4B4C" modified="2020-12-02" version="1">MALTNNHRYFMQYMLKNGATTVNNAQKYCDYISEGEIENLAQLKTLVTEINREISKQSYKLAFNTCEVTNEPYLIWLNTKNDDIAKFQISYSALELEYFHVILQEILRSDEHRITFIVCLNLTSTLTASYSRENGEQVLRKWIKNGYFINKNPYVYLGPRLILEFTAYLKTHLPDSICNLCSELVFWGKSCESCYKTFHIYCLKRYLENQHNCPCCLTEWMSTIEDHSTVEDNNEIEHAANNQTAESDVSDSMDTDDIISSTQTRNRNRNARKNISNISSDEDINEPGPSTRKRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7G7V7</accession>
    <name>A0A6P7G7V7_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cathepsin L-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114336858</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028143047.1">
        <property type="nucleotide sequence ID" value="XM_028287246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7G7V7"/>
    <dbReference type="EnsemblMetazoa" id="XM_028287246.2">
        <property type="protein sequence ID" value="XP_028143047.1"/>
        <property type="gene ID" value="LOC114336858"/>
    </dbReference>
    <dbReference type="GeneID" id="114336858"/>
    <dbReference type="KEGG" id="dvv:114336858"/>
    <dbReference type="InParanoid" id="A0A6P7G7V7"/>
    <dbReference type="OrthoDB" id="5855924at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027954204" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="2">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028143047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028143047.1"/>
        </source>
    </evidence>
    <sequence length="100" mass="12110" checksum="56C06E8F65B70A97" modified="2020-12-02" version="1">MLYKYFLVVFSLYVMANALSDEEQFAEFKQKFQKSYGSKKEEQYRFETFQKNLRYIENHNQKFVNEEVTYSMAVNEFSDQSADEWATKFHGLIPQENYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GBK5</accession>
    <name>A0A6P7GBK5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC114340216</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146736.1">
        <property type="nucleotide sequence ID" value="XM_028290935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GBK5"/>
    <dbReference type="FunCoup" id="A0A6P7GBK5">
        <property type="interactions" value="2162"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028290935.1">
        <property type="protein sequence ID" value="XP_028146736.1"/>
        <property type="gene ID" value="LOC114340216"/>
    </dbReference>
    <dbReference type="GeneID" id="114340216"/>
    <dbReference type="KEGG" id="dvv:114340216"/>
    <dbReference type="CTD" id="22373"/>
    <dbReference type="InParanoid" id="A0A6P7GBK5"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_028146736.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39150" checksum="D30555968982EA6C" modified="2020-12-02" version="1">MAHSGVVPGGKRKEIYKYIAPWPLYSMNWSVRPDKRFRLALGSFVEEYNNKVQVVSLDEDSSEFSAKSTFDHPYPTTKIMWIPDSKGIFPDLLATSGDYLRVWRAGEPDTRLECVLNNNKNSDFCAPLTSFDWNEVDPNLVGTSSIDTTCTIWGLETGQVMGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDHTHTPLLRLAWNKQDPNYLATIAMDACEVIILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAGDDHQALIWDIQQMPRAIEDPILAYTAAEGEVNQIQWGATQPDWIAICYNKSLEILRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GD12</accession>
    <name>A0A6P7GD12_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nephrin isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Nephrin isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC114340732</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14 15">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028147303.1">
        <property type="nucleotide sequence ID" value="XM_028291502.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028147309.1">
        <property type="nucleotide sequence ID" value="XM_028291508.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050517944.1">
        <property type="nucleotide sequence ID" value="XM_050661987.1"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291502.2">
        <property type="protein sequence ID" value="XP_028147303.1"/>
        <property type="gene ID" value="LOC114340732"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028291508.2">
        <property type="protein sequence ID" value="XP_028147309.1"/>
        <property type="gene ID" value="LOC114340732"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050661987.1">
        <property type="protein sequence ID" value="XP_050517944.1"/>
        <property type="gene ID" value="LOC114340732"/>
    </dbReference>
    <dbReference type="GeneID" id="114340732"/>
    <dbReference type="KEGG" id="dvv:114340732"/>
    <dbReference type="CTD" id="44097"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001273">
        <property type="entry name" value="Hibris, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000405">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF136">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044651018" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="128"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="244"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="441"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="538"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="639"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="735"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="832"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="933"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1178"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1240"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028147303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028147303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_028147309.1"/>
        </source>
    </evidence>
    <sequence length="1326" mass="146446" checksum="C696B536D5AB1666" modified="2020-12-02" version="1">MDYTVSFAMLYLVVVLFISHTNAQQQYFRVLPKDVKVQEGGEAMLECEVANLAGQVQWTKDGFALGFLSVIPGFPRYSVIGDRRHGVYNLRVSNASLEDDAEYQCQVGPARLQKAIRANARLNVISPPSSVEILDHTHNSKIEIKENQEFTLECRVKNAKPAAKIVWYRGNVEINIPNREDHTSEVPGKTKDKRVTRYDTHSRISLKPTAEDDFAEYTCEARHEALSQDIPMRATVQLSVLYPPAIPYIEGYVEGETIRRGQTVELVCRCRGGNPAAQLIWYKNGEQIRMAYRTAGRLSENVYTFTADASDNKAKYKCEASNIMSKAPLKAEVEMTVLFSPAHVTISGPTEARVGDPVPLTCTTANSNPPAEIKWLVAGRQVRNVTSRPVISPEGGWITTSNITAVVEPNRRSLVVICHGVNMQLTENVVSTHTINVLYPPSMPFIHGFTQGSHIPAGTIQKISCTSAGGNPLATITWYKNDKKIHSTVRTTDKSVTAEITILTNVTDNGAEYKCEAANSATEIPLIEVINMSVYFPPDHIKIRQEPEDLKPNEEATLFCDSSSSNPPAKLSWWKEGIPVLGYINTTKQGLHGGTVSTIEMKVNVTEQMNGIVYTCQANNEALQRSVHDAITLQVLYKPVFDSNNEESVTGIENEPLIISLKAEGNPANIAYTWTKDGLPITQQSSSNGIERIVSDGSVLNITKLSRNDAGTYTCEALNSQGSNVAMVNITVQYPASIVQTSGNVIANPKEDATLSCSADGNPLADDTITWKRDDFPDFAARTSVMYDKNGTSYLRISSVTREDLGNFLCIVNNGVGNSSSKEVMLIVKHKPEIDTRPQFMKFASDAGDTGKLICRSQASPLARYTWARNGSPINSNTTGKYYSTYKQIDQLITESTLFITHVTSADYGNYECVARNELSFATKSLRLEVTSPPDTPTLLTVLNVTHDSVTLGWTPGFDGGMKASYRIRYRKVDDEGYKYEDVVGGNVTTYVVKELDINTQYVFSIMASNKLGNSKFMPDLLSAKTSVFVEDGVEKVIPEDLLLEKQDLPRIVIISVSVIGIILLFINIALVAGCMLKRRAKRIREQNNQTSKSATIEMYAPSSYNDTVTGETLSSVSEKSETYSNEEGNNEYLDETRKPTSNSYLIEHQPDYPGAYPTYEMQMPAQTGINMAHKTHTLPHPHHHHHHHLAHDQRPRARDDQSLGYHGGMSGKSSYVSAPSPAPPADGSYYNMSDRYLSYPPPLDFQSPPPIPAHPHLTHTHAPITPPLPSNGSLLRHARGVPPPDVLHNTSQNNQILQAQSLSQKRELTSFGNGYGVNEQEGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GEW8</accession>
    <name>A0A6P7GEW8_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="24 25">Fatty acid 2-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">LOC114337321</name>
    </gene>
    <organism evidence="25">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24 25">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028143527.1">
        <property type="nucleotide sequence ID" value="XM_028287726.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_028143528.1">
        <property type="nucleotide sequence ID" value="XM_028287727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GEW8"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648707.1">
        <property type="protein sequence ID" value="XP_050504664.1"/>
        <property type="gene ID" value="LOC126883325"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648708.1">
        <property type="protein sequence ID" value="XP_050504665.1"/>
        <property type="gene ID" value="LOC126883325"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648709.1">
        <property type="protein sequence ID" value="XP_050504666.1"/>
        <property type="gene ID" value="LOC126883325"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648710.1">
        <property type="protein sequence ID" value="XP_050504667.1"/>
        <property type="gene ID" value="LOC126883325"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648711.1">
        <property type="protein sequence ID" value="XP_050504668.1"/>
        <property type="gene ID" value="LOC126883325"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050648712.1">
        <property type="protein sequence ID" value="XP_050504669.1"/>
        <property type="gene ID" value="LOC126883325"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 19" id="KW-0349">Heme</keyword>
    <keyword evidence="14 19" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 18" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_028143527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_028143528.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36756" checksum="1B6B3EDE26A23F35" modified="2020-12-02" version="1">MKEDDKFDVKYNAQSYNIYEFLNNHPGGLNYVQPYKEKDVTKPMSLYEHSKAAYYLLEEYTKGKRRAEEDLESLVNWDKPMLGQVGKLGTKYYEWVTSPVDRNLRLFGNPILECMTITPWYLVPMVWIPVCIYFVIEGTRHYIQITKDASPFVPVVLAFVNGVILWTLIEYSLHRWVFHIEPSGHSKAMIYFHFTIHGLHHKVPFDSRRLVFPPVPAAVIVYIFYSILSVVIPESKQFLTLAGGVSGYVVYDMIHFYLHHGAPKENSYFYHLKRYHNQHHFAHHDNGFGISSTIWDKVFGTAIKLRNLKIGIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GF99</accession>
    <name>A0A6P7GF99_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Golgin subfamily A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC114341669</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="7">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028148281.1">
        <property type="nucleotide sequence ID" value="XM_028292480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GF99"/>
    <dbReference type="EnsemblMetazoa" id="XM_028292480.2">
        <property type="protein sequence ID" value="XP_028148281.1"/>
        <property type="gene ID" value="LOC114341669"/>
    </dbReference>
    <dbReference type="GeneID" id="114341669"/>
    <dbReference type="KEGG" id="dvv:114341669"/>
    <dbReference type="InParanoid" id="A0A6P7GF99"/>
    <dbReference type="OrthoDB" id="5978643at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024858">
        <property type="entry name" value="GOLGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043976">
        <property type="entry name" value="GOLGA_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881:SF46">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10881">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15070">
        <property type="entry name" value="GOLGA2L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A conserved" evidence="4">
        <location>
            <begin position="756"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="241"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="538"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="709"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028148281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_028148281.1"/>
        </source>
    </evidence>
    <sequence length="963" mass="110752" checksum="DB9384F8E583EFB5" modified="2020-12-02" version="1">MADASKAQKLKLANSRKRFKELQELKKKKNATASVDNSEKDLREPTPVDSLVSSTHSSINAESELANVTNTQLPNYFMTTAQSDPATFFENLSTTNTNVGDVGNISDVVETPMFEQHVPFDNNYALFNQTNQQSYIKETQHIIRPNTDSLTIEDPELVQNEIFDHHRHNLIPDQIENSDAQTYEGSYNENNPVHNSFKQNVSDTNLSDFSTQVAHIIPESQSDSNLIIDLEQRNAELTSFLEQEKIQSQQQQLQINELQARIYHLELENATKDNNSVINKLEEDLKCHSQTIRLLVAEKSELSNAVAQQEVTFKNKNSECEELQARLKASRSRAFELEQELNTLKSERIHKETNNHDQNKVLENTLKDFNELRDSKEELEQDILEVREKLKSATQEVLTLQKQNSELSGKLSLADIKIQQLVGADHQTSAAQIESLVQENRALDAEMVSLNNTIKSMSKEHEQSTLHYQQYTEELNTQLLTIQEQYQHIQQENDKLSAEVQNRVHHICDLERQLQNKQNEKVTFTSSNGTGLNVKEELEVTKELCVQLQMEKTELEENYTKALNEKEMLMKELAAKNDSLNQLETMVEQLKGNQPDTAKLLATMESDKVAAARAVQQNMELKEQLESMAEVFAKMNNDKVELTEKLSIQQSASKDLLEKLQKTELHLQMLTDAIEIKDRELSHLREASELNEVLDHEEQHTDESHETCSHTLQNELKEATETIVKLTNELNNQRNQMSPSPQVSVGDDISYLLKQLEELKLKNQELETKLENHTIDDNYNNKLLTEEESESILQKEEAMKRLEEKFKRRMQDIADLTEEKQRLEHLVLQLQGETETIGEYVALYQHQRMILKQKAMEKDQQFKQLATDREQIKIKLEKLNHLVGELLKSKTLSSEILGQCERLHESENKEVETTEDFNKEESPHTETAEEILTLLSEIKSSNLVEPKESIHHCPFCSGQLITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GFL5</accession>
    <name>A0A6P7GFL5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 130 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114341827</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028148441.1">
        <property type="nucleotide sequence ID" value="XM_028292640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GFL5"/>
    <dbReference type="FunCoup" id="A0A6P7GFL5">
        <property type="interactions" value="1212"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050658594.1">
        <property type="protein sequence ID" value="XP_050514551.1"/>
        <property type="gene ID" value="LOC126889885"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GFL5"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050514551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028148441.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36656" checksum="D5D589FCB979DB7B" modified="2020-12-02" version="1">MGERKGVNKYYPPDYDPRVGGLNKFLGTHALRERARKIDKGIIIIRFEMPYNIWCDGCKNHIGMGVRYNAEKTKVGMYYTTPVYEFKMKCHLCDNHFVIRADPANLDYVIQSGARRQENRWDPTTNEQVVPETKETQKRLFDDSMFKLEHGSEDKTTAESVKPGLVKLFNRNEDVWADSYSANQMLRAQFRKANYEAKQKVTHDQVLLKKSSLDIPLLPEREEDKKVASLLSMKLKPSKSIDENMETIRKEIISQSSLPTSNFSRIKEDKAMKILNQSKKDLGIIKKRSNKSETEEKDEPKKAKTSLVGDYGSTSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GH08</accession>
    <name>A0A6P7GH08_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tenecin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC114338017</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028144393.1">
        <property type="nucleotide sequence ID" value="XM_028288592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GH08"/>
    <dbReference type="EnsemblMetazoa" id="XM_050649040.1">
        <property type="protein sequence ID" value="XP_050504997.1"/>
        <property type="gene ID" value="LOC126883473"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050649041.1">
        <property type="protein sequence ID" value="XP_050504998.1"/>
        <property type="gene ID" value="LOC126883474"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GH08"/>
    <dbReference type="OrthoDB" id="10038290at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028073939" evidence="9">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050504997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_028144393.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="8926" checksum="9CCF0B9639AF42A5" modified="2020-12-02" version="1">MKAVIFCAIFAVVVMQVLALPVDEIEEKDGHLRFKRFTCDVLGSISYMGVSMHDNPCSIKCRMMGSDGGHCDEQKECHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GJ26</accession>
    <name>A0A6P7GJ26_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing regulator female-lethal(2)D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC114338797</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028145213.1">
        <property type="nucleotide sequence ID" value="XM_028289412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GJ26"/>
    <dbReference type="EnsemblMetazoa" id="XM_028289412.2">
        <property type="protein sequence ID" value="XP_028145213.1"/>
        <property type="gene ID" value="LOC114338797"/>
    </dbReference>
    <dbReference type="GeneID" id="114338797"/>
    <dbReference type="KEGG" id="dvv:114338797"/>
    <dbReference type="CTD" id="36527"/>
    <dbReference type="InParanoid" id="A0A6P7GJ26"/>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028145213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_028145213.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37691" checksum="27CF17E2C1BA20AD" modified="2020-12-02" version="1">MLILSKPDMMSESGDVPQSLSPAERDKPPSRVVIAEPEVSCYSIQEWQNSWRQQDSYINLLERKANQQEGDLADLRLVNERIKGQLFESQQREKNLVRRLAAKEQETQDYVCQLNELKSSQVPTTSSLRTVLLDPAVNSILHHLQSELQATHLKLEDTQNELSAWKFTPDSNTGKRLMAKCRLLYQENEELGKITSSGRIAKLESDLALQKSFSEEVRKSQNELDSFLADLDEDVEGMQSTILFLQQELKKSKETIQVLQKENITLKQGSNGRANGDTSVCEREQTDSESEMERTRGVKRIRRSSVLSIDYNEDDTLVINTNGDAAISSDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKA4</accession>
    <name>A0A6P7GKA4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SAFB-like transcription modulator isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC114339896</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_028146392.1">
        <property type="nucleotide sequence ID" value="XM_028290591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKA4"/>
    <dbReference type="EnsemblMetazoa" id="XM_028290591.2">
        <property type="protein sequence ID" value="XP_028146392.1"/>
        <property type="gene ID" value="LOC114339896"/>
    </dbReference>
    <dbReference type="GeneID" id="114339896"/>
    <dbReference type="KEGG" id="dvv:114339896"/>
    <dbReference type="OrthoDB" id="6159259at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028146392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_028146392.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="55186" checksum="EAFD2BAA14BFA867" modified="2020-12-02" version="1">MSSLIPDDPTTQNEVETRGAEDDPDLTIKFKLDDSIQSESSTSDSTKLTIPVESEAGEEIKITKVNGSDCNKEQNVQEAKESIWVSNLNRDVKAVDVRELFGKITKVQGVKILTNNSNYFAYVTLKDAEKVAKCIEKLNNTVLNGEKILLSSTKPCIQQAETHAKKKEDNKDLVKQDIKVAAETSNKGNNGKHTSEIIKTDKNSDPSDNSVIAEQKREIKKLKQELKIADNKNSSLKSDLRAERRKYDTIYSKYQNLRRDMEKMENENRQKRRKLILDQENFEHSIKMKMVDVEKLKLDLNRQLEETKQLKERLSKEVNKLSDMKNVNTYKRTRSPSRRDSTSHRGQPQGKKFRYFHDFDKSKTPPPPNLRNESGKQSGYSAASSSNEAPDFSRGMKPPGTGFNRHEKSTPFQQSIHPGPRANTSNLDQRRPKTSNLDQRRANPSNVDQRRVNNYDYGAYSASQPYANALPVRGNNNFPYYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GKY4</accession>
    <name>A0A6P7GKY4_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC114340063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114340063</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the attacin/sarcotoxin-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028146587.1">
        <property type="nucleotide sequence ID" value="XM_028290786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GKY4"/>
    <dbReference type="EnsemblMetazoa" id="XM_050648037.1">
        <property type="protein sequence ID" value="XP_050503994.1"/>
        <property type="gene ID" value="LOC126882955"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GKY4"/>
    <dbReference type="OrthoDB" id="8117451at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005521">
        <property type="entry name" value="Attacin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03769">
        <property type="entry name" value="Attacin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027709580" evidence="8">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Attacin C-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050503994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028146587.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17815" checksum="2E38B9A955D897D2" modified="2020-12-02" version="1">MKSIAIIAFCISVVVSLPLDIIENESGQEYVLVPVHRERRDLTWGANQNGYSLGQKGNIWENGAHKFDGAYTGSKAWDSHGLKPDSFGGRVEYTNKPTKTTAFVGADRTPGYGTDLNAGVKYNFVQDKKLNIDLTGQVSQHHGGPFGNTKPEAGVYLNFNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GQH2</accession>
    <name>A0A6P7GQH2_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC114345210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC114345210</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028151829.1">
        <property type="nucleotide sequence ID" value="XM_028296028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GQH2"/>
    <dbReference type="EnsemblMetazoa" id="XM_050641496.1">
        <property type="protein sequence ID" value="XP_050497453.1"/>
        <property type="gene ID" value="LOC126878653"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7GQH2"/>
    <dbReference type="OrthoDB" id="6620644at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027842398" evidence="2">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050497453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_028151829.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15725" checksum="9B9E72980C35143A" modified="2020-12-02" version="1">MFFRMLVLFSLSLIYIEIAESTPVLVQTSRHFLYGVPGYIPVYIRKGDTPLEEINPNLAEAFYVNAQKHNRITYGRFIGGKSDNEAIKPGYPDGIKISEVDKTFLDTDLDVEDEEPSVSKPQESKTEKPSSNIQKIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7GSG8</accession>
    <name>A0A6P7GSG8_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-Cys peroxiredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC114342412</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:10008"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028149017.1">
        <property type="nucleotide sequence ID" value="XM_028293216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7GSG8"/>
    <dbReference type="FunCoup" id="A0A6P7GSG8">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028293216.2">
        <property type="protein sequence ID" value="XP_028149017.1"/>
        <property type="gene ID" value="LOC114342412"/>
    </dbReference>
    <dbReference type="GeneID" id="114342412"/>
    <dbReference type="KEGG" id="dvv:114342412"/>
    <dbReference type="InParanoid" id="A0A6P7GSG8"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="2"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028149017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_028149017.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24605" checksum="51A742257069A307" modified="2020-12-02" version="1">MVILGEQFPNFSAKTTIGDITFHDWLGESWGILFSHPADFTPVCTTELARLVKLIPEFTKRNTKIIALSCDSVDSHLKWSSDILNYSGCLDGTFPYPIIEDQDRDLASELGIIDSDEKDSDGIPLSARAVFIVDPKKKMRLSILYPATTGRNFNEILRVLDSLQLCDKHKIATPADWVPGEDVMVQPTVSDTELKSLFPYVKVTTVPSGKNYIRMIPDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7H239</accession>
    <name>A0A6P7H239_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cathepsin B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC114345135</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028151758.1">
        <property type="nucleotide sequence ID" value="XM_028295957.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_050500216.1">
        <property type="nucleotide sequence ID" value="XM_050644259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7H239"/>
    <dbReference type="EnsemblMetazoa" id="XM_050644259.1">
        <property type="protein sequence ID" value="XP_050500216.1"/>
        <property type="gene ID" value="LOC114345135"/>
    </dbReference>
    <dbReference type="GeneID" id="114345135"/>
    <dbReference type="KEGG" id="dvv:114345135"/>
    <dbReference type="InParanoid" id="A0A6P7H239"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027834497" evidence="8">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="79"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050500216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_028151758.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="36197" checksum="247F22956486A468" modified="2020-12-02" version="1">MKAAFIITLLLPIVLSYKGNPNPLSNDFINYINSKQSTWVAGKNFDENLSIQEIKNLLGAKKGKLGVAKEFTHSEDIQVPNSFDARENWKECSDVISTVVDQSDCGSCWAVAAASAMSDRRCIASQGKLKVPVSAENLLSCCDSCGYGCEGGYPTMAWSYWIDTGITTGGLYGSKQGCQPYSLQPCEHHTEGNKVQCSTLDYDTPSCKHKCDDSALNYKSELTFGSGSVRNFYSVANIQKEILTNGPVEAAFDVYSDFVNYKSGVYQHVAGEYLGGHAVRILGWGEESGVPYWLVANSWNEDWGDKGLFKIRRGNNESGFEDSIVAAPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A6P7HDY5</accession>
    <name>A0A6P7HDY5_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosomal protein D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC114347469</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4">Whole insect</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028153970.1">
        <property type="nucleotide sequence ID" value="XM_028298169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A6P7HDY5"/>
    <dbReference type="EnsemblMetazoa" id="XM_050645310.1">
        <property type="protein sequence ID" value="XP_050501267.1"/>
        <property type="gene ID" value="LOC126881208"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645311.1">
        <property type="protein sequence ID" value="XP_050501268.1"/>
        <property type="gene ID" value="LOC126881208"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_050645312.1">
        <property type="protein sequence ID" value="XP_050501269.1"/>
        <property type="gene ID" value="LOC126881208"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A6P7HDY5"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_050501267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_028153970.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="11611" checksum="2CFCD5DB13999EA5" modified="2020-12-02" version="1">MSDDAATTPSKRGRKANAEKAEKVEKAEKVDTKKRGKKDADDEGASPAKRGRGRPKGTTKKKSAVKPKAKSAGASRGRGRPKKKEEPKDSGDEDNDDNDAGEEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IAJ5</accession>
    <name>A0ABM5IAJ5_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_028128612.2">
        <property type="nucleotide sequence ID" value="XM_028272811.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028272811.2">
        <property type="protein sequence ID" value="XP_028128612.2"/>
        <property type="gene ID" value="LOC114324905"/>
    </dbReference>
    <dbReference type="GeneID" id="114324905"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028128612.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="485" mass="55988" checksum="6E2BBC59E049E07F" modified="2025-10-08" version="1">MPLTCIVVNCGSRSKRDKVSFFAIPKPLKFKHAIHLNELTVKRRKKWIRAIRRADLTESKLKYQKVCSKHFIQGQPAKLEDVNDPDWIPTQKMGYSRGPVKRKQDLERLERVKKRSSTKVSQEDNDTFIENENNTVSESNTTAMYEDSTGTETQTELTSDDIEQMAQQLKFANKKIDELTRRINKTILSFESLETDNPKCLYYTGLNFSVLKSVFDRIKPFIPSSSVTVLDPSQQYLLTLMKMRLNLDFKYLAYQFGISQSTCSTYFNTIISIMYQRFKNSIKWPDREIIKKNMPSCFREVFHDKTTIIIDCFEVFIQKPASYLTQQQTWSNYKHHNTVKFLIGITPQGCISYISKAWGGRTSDKQIVELSGFLDKIEPQDIVIADRGFLIKEFLDVLQAKLVIPAFTKGKKQLLPLELEETRNIAQVRIHVERVIGSIKNKFNIFSEPLPISMLTHVTDGINIVDKIIFIACVLINLCPPIVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IHM9</accession>
    <name>A0ABM5IHM9_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="RefSeq" id="XP_028132982.2">
        <property type="nucleotide sequence ID" value="XM_028277181.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028277181.2">
        <property type="protein sequence ID" value="XP_028132982.2"/>
        <property type="gene ID" value="LOC114328348"/>
    </dbReference>
    <dbReference type="GeneID" id="114328348"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0835">Urea cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028132982.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="383" mass="42653" checksum="B0954AE69B4CB9AF" modified="2025-10-08" version="1">MLKKLITECVFAKRQYSAEAKKIGILGIPFSKGQPKKGVTNGPDAIRKGGLVEQLSQFYNKSLIKDYGDLDYPLLKEIGTVENMKSYEEVMSCNKELSKKVQEIVADNRVCLNLGGDHAIAIGSIDGHLKAKKDICVIYVDAHCDINTNKTSGSGNIHGMPVSIVTKEMCEYWQDLPGMEWQEPTLSVRNIAYIGLRSVDPYERVFVDKFGIAAFSMAEIEECGIHTVINMALKAIDPEQNRSIHVSFDIDALDPNDAPCTSITIPGGLTVREGIHILERIHDTGRLNVMDIVELNPDIGTERDAQKTVGVAIQLLAAACGFKRGGIRPKDATLPLQNNQNKNTNSYIFFYFMRIATFLFYERYIAYDAISTSPRLLNVSHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5IJV6</accession>
    <name>A0ABM5IJV6_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vitellogenin-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028134500.2">
        <property type="nucleotide sequence ID" value="XM_028278699.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028278699.2">
        <property type="protein sequence ID" value="XP_028134500.2"/>
        <property type="gene ID" value="LOC114329554"/>
    </dbReference>
    <dbReference type="GeneID" id="114329554"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046492164" description="Vitellogenin-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="9">
        <location>
            <begin position="1476"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1714"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1716"/>
            <end position="1732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028134500.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1835" mass="209994" checksum="37D0C11BF600FC2E" modified="2025-10-08" version="1">MWSQVVLCMLVGLAYAKNNPAWTDNQEYVYQVRGRTLTGLMDVSDDYSGIFLKAKLRIQPRGDGKLQALIENPQYTQIHTNLDDGWDAEAPEEELSWKPLPMSSKPFQIQMENGKIKRLIVNRDLNNWEANMIKSIVSLFQLNTNGENTLPSPLNSLPEHGSNSGVFLTMEDTILGETETLYKIRPVPEHTLLTNEKEARFVELKQKRQQNGDLIEVNKHEDFTNNRELPAYVYGFGDYLLPNKAATNQMGTYFSRDSSSRAILAGDLNHHDILFTSTKNTIVISPSISDEQKGAVYSYLEAKLEDVKSGTQKIGEINPAVHFENLVYSYNQPFSKDNHVEGDENQNQRNQRTSDAYRYSFEEEEYEDRDSYKRLAHRRHQRSLAKKYGLKHDNSEENLQNQPRINEAPESSLLTLTTGYKGMSIKNSVNVVKKSEKLIKKIASDLQDQEKDHHEKTLERFVNLETLMRLMNFDELKQVSDKVMRQSRNGQEAATSAVTRDAIAQTGTGPALLVIQEWIQEGKIEGEEASQVVIVAFSSVRLPTMEHLRTAFKLVKHQKVEDQFPLNNTALTGFTDLLRKAVIQKNVAKSEYPVNSFGRFRTEESKKFVREEVMPYLKEKLQKAVQRAETHRIHAYIRAVGNLPDPRILEIFEPFLEGKQQSSQFQRLLMVLAMGKLTETHPEDALAVFFRIYQNPAEHQAVRIAAVFHIMRSRPTLQILQVMASNTNNENNDYVNAVVKQSIEELTELEAPEFAYIRSIAKGVQPLLTDKEFPAQFGGNYIRGYVIEELNTLYKTSTQIIPSKDEYVPKGLRYTLRARFNGLYQKLINMQAIVSSVEDLIAVAYQKTQSFADKQQQQQEHAQEQLNNPWSSQNIAKLLNLKAEEREQLEAYWYLELLDTPVSMYGFDNTTMNQLPKLLSALEAAMSKGKQINQFKLINSKEMAIAIPTAMGIPFLYTYDSPMLVKVQGQVGGQVKPQLVQNQKIQTPENIKLQATIRATVSGKTQGRVTFIAPFEHEQYIAGYDKHWEINIPKVKTDVEIDLNLKEIKVLFELLPERSVNLLHFRSWPYTAKSDVTDFEPLSAQKRTREIEPDNMHAFKTTVGQKSIGLGLDVEVKHERKFIHSELINRLFSQNGVIDGAKALWDVNNLQSSEINISLNFDLATVHFIIIHSRYDQNYQQKGESPKSEYKVDEKMSPDERQQQMMDAVASGINSVSVKSLDTTIDLIGDRYIQYLLSGAVAKSNVDPKSNVRIFFKRFSLDPELKNYETHFVSQSMIPNTNALDLQYSLSKNEPKIDTKMEVTFGYSDESKSKILAEIKHRRTEERKQYLKELPLYEQCKQEMKESNKQLFSCTNLTMDSNLLDRIEVKLQSQNLKLELLDAIEMAYKAARFELLPSLQVKNKQQPVQPNSAEMDIKFHPDLSFVNITVRTHNQKVSAKNIEVNDKVRIITVAHPVFNLRDRVLSELLVGDTYRDFCTVDRYAVNTFSNRTYDAELSNKWTVMAQYIPKLPRQSDQQQPQESAHKQLQNQLENFAVLVRDSKQPGQKELQIVVSSPRSNFETISILFVPNQGQQSKAQVSVNGQMIQVNEKQSNDIKDGYVQIYELPNREVKAEIDGVFYVIYDGERVRMTAKNGKMKNAIRGICGQFNGQDSEDFLTSENCIARKPHKFVKSFEVEGDEGKQVRKEFAGSSNQCVKIQTPLYINVITDEHARRNSQGKSSNKSQYYSGKSFSRGSSRDSSEEGSEEDNDCLLHQTKYFVQGAKICFSTKPLPSCRRHCQPRDQRKKSVGVHCIQKSNVAMLWKIQVDNENSPDFSHKKEHTTLKFEVPESCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ILR3</accession>
    <name>A0ABM5ILR3_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028135872.2">
        <property type="nucleotide sequence ID" value="XM_028280071.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028280071.2">
        <property type="protein sequence ID" value="XP_028135872.2"/>
        <property type="gene ID" value="LOC114330665"/>
    </dbReference>
    <dbReference type="GeneID" id="114330665"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF4">
        <property type="entry name" value="GH03113P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="228"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="320"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028135872.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="476" mass="53841" checksum="D434D4CA1FE621F8" modified="2025-10-08" version="1">MALNECVELSFNMKMCIGLIVFWQVVITGFCEDLTDFSSHPTTVKAKENNTVLLPCHLNTLSNDEAHAKSVRWYKDEDLIADSANESLTPPDRHLLWENGSLEILFVQPDETGEYTCEILRSEPWGPVKQKHAIEVLHSPSVEPFPPTGFLQVRLGEEVRMSCKGEGIPYPIITWSSKGEELKLIDHREILKFTASDRQMAGVYECIANNGVGEPAKASIELNIIYPPEMLTSRSWIHTAPGHRVQIDCKVSSDPQATVTWLKGEVPVHLDNRVVPMIDGDKHTLLIRNVQRSDFGIYTCRAINELGQGELAIQLSGVPNPGVFKRTEEKNANSKTSYTLIWEVDSYTPIIEYNLWFRPYKPRSGTHLPNWTKLTIPTEHSSGPVYSKSYTIKGLKERSVYEALLVSRNRYGWSKPSPILRFATAGAELNEDMITTVQVSIQENMFTLQSSSSILCQSHLTWMYILLFLILIKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INB3</accession>
    <name>A0ABM5INB3_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_028137189.2">
        <property type="nucleotide sequence ID" value="XM_028281388.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281388.2">
        <property type="protein sequence ID" value="XP_028137189.2"/>
        <property type="gene ID" value="LOC126878431"/>
    </dbReference>
    <dbReference type="GeneID" id="126878431"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="11">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137189.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="259" mass="29804" checksum="12E6000EB67E4237" modified="2025-10-08" version="1">MSSETIENFFGVYLLYCLNPRYKGRTYIGYTVDPNRRLKQHNKGKQFGGAWKTSNRGPWSMVMIIHGFPNDISALRFEWAWQHPHTSRRLKHVGKKKRNEKTFNFCLRVLSEMLKIGPWCRLPLTIRWLNSTFATDFAVPPLHMPICHGSVISKKIEKSSSTQSSSNLSYKICDICSLAITGQILKCVNYTCDLNSHVTCLSNKFLKLGEYVPVEGECPKCEKVFLWGDLVRKFKGCYNNMDLEVTVEDAAEFYMSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5INZ0</accession>
    <name>A0ABM5INZ0_DIAVI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_028137724.2">
        <property type="nucleotide sequence ID" value="XM_028281923.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028281923.2">
        <property type="protein sequence ID" value="XP_028137724.2"/>
        <property type="gene ID" value="LOC114332186"/>
    </dbReference>
    <dbReference type="GeneID" id="114332186"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009832">
        <property type="entry name" value="DUF1397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07165">
        <property type="entry name" value="DUF1397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045390313" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EnsemblMetazoa" id="XP_028137724.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001652700"/>
        </source>
    </evidence>
    <sequence length="215" mass="24921" checksum="3F7D18A75BD9ECE0" modified="2025-10-08" version="1">MQKIAFFIFMGFMHHAYIMAPWYSKDTVECITPKIKTVIKEQIECGQNYTPPFDTMKITHRKNQIRPFYFVTDRCSFRPGIDVCLERSMNLVSDCFNSSNLEGLATWKKIDNEVTEYVCKNNSEVGYDLFENSTAKCYIEQITYALDRCVPLLKLNTTIYDIQGLTQSCKNSEEFSTCFIKDLRKSCSEKVIEMASTLIKIVESHLCPKKDDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2025-10-08" modified="2026-01-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0ABM5ISC7</accession>
    <name>A0ABM5ISC7_DIAVI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Diabrotica virgifera virgifera</name>
        <name type="common">western corn rootworm</name>
        <dbReference type="NCBI Taxonomy" id="50390"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Cucujiformia</taxon>
            <taxon>Chrysomeloidea</taxon>
            <taxon>Chrysomelidae</taxon>
            <taxon>Galerucinae</taxon>
            <taxon>Diabroticina</taxon>
            <taxon>Diabroticites</taxon>
            <taxon>Diabrotica</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="EnsemblMetazoa"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_028140494.2">
        <property type="nucleotide sequence ID" value="XM_028284693.2"/>
    </dbReference>
    <dbReference type="EnsemblMetazoa" id="XM_028284693.2">
        <property type="protein sequence ID" value="XP_028140494.2"/>
        <property type="gene ID" value="LOC114334616"/>
    </dbReference>
    <dbReference type="GeneID" id="114334616"/>
    <dbReference type="Proteomes" id="UP001652700">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF105">
        <property type="entry name" value="FI02074P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="33"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
    
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